020314
Data extracted from PhosphoSitePlus(R), created by Cell Signaling Technology Inc. PhosphoSitePlus is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 3.0 Unported License. Attribution must be given in written, oral and digital presentations to PhosphoSitePlus, www.phosphosite.org. Written documents should additionally cite Hornbeck PV, Kornhauser JM, Tkachev S, Zhang B, Skrzypek E, Murray B, Latham V, Sullivan M (2012) PhosphoSitePlus: a comprehensive resource for investigating the structure and function of experimentally determined post-translational modifications in man and mouse. Nucleic Acids Res. 40, D26170.; www.phosphosite.org.

PROTEIN	PROT_TYPE	ACC_ID	GENE_ID	GENE_SYMB	CHR_LOC_HUM	ORG	MOD_RSD	MOD_TYPE	SITE_GRP_ID	MODSITE_SEQ	IN_DOMAIN	ON_FUNCTION	ON_PROCESS	ON_PROT_INTERACT	ON_OTHER_INTERACT	PSP ARTICLE ID	LTP_EXPT_COUNT	HTP_EXPT_COUNT	CST_MS2	NOTES	
AQP2	Channel, misc.; Membrane protein, integral; Membrane protein, multi-pass	P41181	359	AQP2	12q12-q13	human	K270	UBIQUITINATION	999601	QSLPRGTkA______		protein degradation; intracellular localization; phosphorylation				18021034	4	0	0	stimulates phosphorylation of S261	
DDX58	EC 3.6.1.-; EC 3.6.4.13; Hydrolase	O95786	23586	DDX58	9p12	human	S854	PHOSPHORYLATION	17484202	HPKPKQFsSFEKRAK	RIG-I_C-RD	molecular association, regulation; enzymatic activity, inhibited		DDX58(DISRUPTS)		17431516	1	1	0	dephosphorylation of T770, S855, S854 stimulates multimer formation;  	
PDK1	EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor)	O55173	81745	Pdpk1		rat	Y379	PHOSPHORYLATION	447695	DEDCYGNyDNLLSQF		enzymatic activity, induced	translation, altered; cell adhesion, altered			4313624	8	1	0	Induces fibronectin expression and deposition and increases AngII mesangial cell hypertrophy	
CD200R	Membrane protein, integral; Receptor, misc.	Q8TD46	131450	CD200R1	3q13.2	human	Y302	PHOSPHORYLATION	458379	TEKNNPLyDTTNKVK	ABC2_membrane_3; Bravo_FIGEY	molecular association, regulation		Dok2(INDUCES)		10353934	2	0	13	recruitment of RasGAP by Dok2	
GSK3B	EC 2.7.11.1; EC 2.7.11.26; KINASE; Kinase, protein; Protein kinase, CMGC; Protein kinase, Ser/Thr (non-receptor)	P18266	84027	Gsk3b		rat	S9	PHOSPHORYLATION	449111	SGRPRTTsFAESCKP		molecular association, regulation; enzymatic activity, inhibited; activity, inhibited	apoptosis, altered; apoptosis, inhibited; transcription, altered; cell growth, altered	14-3-3 beta(INDUCES)		3256106; 10353938; 4563; 6439; 4904525; 1380; 4917200; 20655007	345	20	210	phosphorylation decreases apoptosis	
QIK	EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, CAMK; Protein kinase, Ser/Thr (non-receptor)	Q3LRT3	315649	Snf1lk2		rat	T484	PHOSPHORYLATION	478056	RSGQRRHtLSEVTNQ		protein degradation				18021012	2	4	78		
PTEN	Carbohydrate Metabolism - inositol phosphate; EC 3.1.3.16; EC 3.1.3.48; EC 3.1.3.67; Motility/polarity/chemotaxis; Nuclear receptor co-regulator; PHOSPHATASE; Phosphatase, lipid; Tumor suppressor	P60484	5728	PTEN	10q23.3	human	S380	PHOSPHORYLATION	448313	EPDHYRYsDTTDSDP		protein stabilization; enzymatic activity, inhibited	cell differentiation, altered; cell motility, altered; transcription, altered	PTEN(INDUCES); PTEN(DISRUPTS)		1252602; 5121518; 767; 2670102; 2904	22	0	0	cell migration in embryo	
MCM3	DNA replication; EC 3.6.4.12	P25206	17215	Mcm3		mouse	S732	PHOSPHORYLATION	475062	SQEKTDDsQETQDSQ	CPSF100_C	intracellular localization				9265	1	5	1	Preferentially localized to the soluble nucleoplasmic fraction.	
PSMA2	EC 3.4.25.1; Protease; Proteasome complex	P17220	29669	Psma2		rat	Y121	PHOSPHORYLATION	450235	VASVMQEyTQSGGVR	Proteasome	intracellular localization				2858	1	0	0		
tau iso8	Cytoskeletal protein	P10636-8	4137	MAPT	17q21.1	human	T231	PHOSPHORYLATION	449079	KKVAVVRtPPKSPSS		molecular association, regulation; intracellular localization; protein processing; protein conformation; phosphorylation	apoptosis, altered; cytoskeletal reorganization; signaling pathway regulation	TUBA4A(DISRUPTS); Fyn(DISRUPTS); TUBA1A(INDUCES); Pin1(INDUCES)		4578; 14821610; 5955607; 6708; 2365406; 7021; 2587206; 17630402; 15331007	74	20	10	T231 phosphorylation is required for MAPK signaling.; regulates phosphorylation of tau S199 and S262; The amount of tau in partticulate fraction increased in R406W and V337M mutants compared to WT.; Phosphotylated sites found in the somato-dendritic campartment but not in the axon, where tau was not phosphorylated (T205 and T217),  or not simultaneously phosphorylated (T231 and 235). ; induced  tau-tau association and formed aggregates in cell nucleus	
H1R	GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR	P35367	3269	HRH1	3p25	human	T142	PHOSPHORYLATION	453405	YLKYRTKtRASATIL	7tm_1	receptor desensitization, altered; activity, inhibited				4674; 4121	2	0	0	T142 phosphorylation had an inhibitory effect on T140-mediated receptor downregulation.	
IRS1	Adaptor/scaffold; Motility/polarity/chemotaxis	P35569	16367	Irs1		mouse	S612	PHOSPHORYLATION	447562	DDGYMPMsPGVAPVP		protein degradation; molecular association, regulation		PIK3C2A(DISRUPTS)		4032; 6804	30	4	3		
Bub3	Cell cycle regulation	O43684	9184	BUB3	10q26	human	S19	PHOSPHORYLATION	15180600	PPEDGISsVKFSPNT	WD40		apoptosis, induced			15031335	1	1	0	caspase-independent mitotic death (CIMD)   	
Kit	EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Protein kinase, TK; Protein kinase, tyrosine (receptor)	P05532	16590	Kit		mouse	Y723	PHOSPHORYLATION	448017	SCDSSNEyMDMKPGV	Pkinase_Tyr	molecular association, regulation; phosphorylation	cell cycle regulation	PIK3R1(INDUCES)		4843008; 2455804; 5661; 3729	13	5	53		
MRE11A	Cell cycle regulation; DNA binding protein; DNA repair; Deoxyribonuclease	P49959	4361	MRE11A	11q21	human	S382	PHOSPHORYLATION	11506403	PFSVLRFsQKFVDRV	Mre11_DNA_bind	molecular association, regulation			DNA(DISRUPTS)	11484420	1	0	0		
Syk	EC 2.7.10.2; KINASE; Kinase, protein; Protein kinase, TK; Protein kinase, tyrosine (non-receptor)	P48025	20963	Syk		mouse	Y317	PHOSPHORYLATION	447658	STVSFNPyEPTGGPW		molecular association, regulation; enzymatic activity, inhibited; protein conformation; phosphorylation	endocytosis, altered; signaling pathway regulation; transcription, altered	Cbl(INDUCES); PIK3R1(INDUCES)		1973; 4300; 798; 4357	14	18	1010	Mutant Y342F/346F Syc showed less efficient FcERI-induced degranulation, and delayed calcium influx.  ; AKT phosphorylation	
Kir6.2	Channel, potassium; Membrane protein, integral; Membrane protein, multi-pass	Q61743	16514	Kcnj11		mouse	S385	PHOSPHORYLATION	2103601	AKPKFSIsPDSLS__		activity, induced; protein conformation				1968364	2	1	0		
eEF1A2	Translation; Translation elongation	Q05639	1917	EEF1A2	20q13.3	human	S358	PHOSPHORYLATION	27930803	GQISAGYsPVIDCHT	GTP_EFTU_D3	protein degradation; molecular association, regulation				27902349	1	0	0	increased association with polysomes and  newly synthesized polypeptides (NSPs)	
CABP4	Calcium-binding protein	Q8VHC5	73660	Cabp4		mouse	S37	PHOSPHORYLATION	1315600	PALTRRRsKKESWHP		activity, induced; molecular association, regulation		CACNA1F(INDUCES)		1172845	2	1	0	Ca(2+) current kinetics	
SRC-3	ACETYLTRANSFERASE; Acetyltransferase; EC 2.3.1.48; Motility/polarity/chemotaxis; Nuclear receptor co-regulator; Transcription, coactivator/corepressor	Q9Y6Q9	8202	NCOA3	20q12	human	S857	PHOSPHORYLATION	453084	PPYNRAVsLDSPVSV		molecular association, regulation	carcinogenesis, induced; cell motility, induced; transcription, induced	ER-alpha(DISRUPTS); ETV4(INDUCES)		25227637; 4214	8	23	5	 migration and invasion; MMP2, MMP9, and MMP10 gene expression; Mutations to alanine inhibited protein-protein interactions. 	
G-alpha(11)	G protein; G protein, heterotrimeric; G protein, heterotrimeric alpha G(q)	P29992	2767	GNA11	19p13.3	human	S154	PHOSPHORYLATION	471084	RRREYQLsDSAKYYL	G-alpha	molecular association, regulation; receptor desensitization, altered		5-HT(2A)(DISRUPTS)		12075; 8996	2	0	0		
FAK iso3	EC 2.7.1.112; EC 2.7.10.2; KINASE; Kinase, protein; Protein kinase, TK; Protein kinase, tyrosine (non-receptor)	P34152-3	14083	Ptk2		mouse	Y407	PHOSPHORYLATION	447888	IIDEEDTyTMPSTRD		enzymatic activity, inhibited; phosphorylation	cell cycle regulation; cell motility, altered; cell adhesion, altered; cell growth, altered			2706603	27	11	135		
Dok1	Adaptor/scaffold; Motility/polarity/chemotaxis	Q99704	1796	DOK1	2p13	human	Y146	PHOSPHORYLATION	455786	EMLENSLySPTWEGS		molecular association, regulation		Dok2(INDUCES); Dok1(INDUCES)		6981	2	1	3	Dok1/Dok2 oligomerization required for ERK1/2 and NFAT activation	
doublecortin	Cytoskeletal protein; Motility/polarity/chemotaxis	O43602	1641	DCX	Xq22.3-q23	human	S378	PHOSPHORYLATION	451111	PQKTSAKsPGPMRRS		molecular association, regulation	cytoskeletal reorganization	TUBA1B(DISRUPTS); ACTA1(INDUCES)		5214	5	1	4		
CD5	Cell surface; Membrane protein, integral	P06127	921	CD5	11q13	human	Y453	PHOSPHORYLATION	447774	ASHVDNEySQPPRNS		activity, induced				6325	3	8	308	phosphorylation of Y453 is essential for CD5 functions, including inhibition of the BCR-induced calcium response, inhibition of Akt translocation, inhibition of IL-2 production.	
mAChR M2	GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR	P08172	1129	CHRM2	7q31-q35	human	T423	PHOSPHORYLATION	487430	CIPNTVWtIGYWLCY	7tm_1	molecular association, regulation				12276	1	0	0		
MFN2	Cell cycle regulation; Cytoskeletal protein; EC 3.6.5.-; Hydrolase; Membrane protein, integral; Membrane protein, multi-pass; Mitochondrial	O95140	9927	MFN2	1p36.22	human	S27	PHOSPHORYLATION	25594503	HMAEVNAsPLKHFVT		protein degradation; ubiquitination	apoptosis, induced	HUWE1(INDUCES)		25573567	1	1	0	HUWE1 associates with Mfn2, and leads to Its ubiquitination and degradation.	
KCNMA1	Channel, potassium; Endoplasmic reticulum; Membrane protein, integral; Membrane protein, multi-pass	Q12791	3778	KCNMA1	10q22.3	human	S992	PHOSPHORYLATION	469989	HGMLRQPsITTGVNI		activity, induced				8591	4	1	0		
RYR2	Channel, ligand-gated; Membrane protein, integral; Membrane protein, multi-pass	E9Q401	20191	Ryr2		mouse	S2030	PHOSPHORYLATION	455603	TIRGRLLsLVEKVTY		activity, induced				970004	8	3	1	increased Ca++ release	
CCNE1	Activator protein; Nuclear receptor co-regulator	Q61457	12447	Ccne1		mouse	T393	PHOSPHORYLATION	447676	PPPSVVLtPPPSSKK		protein degradation; enzymatic activity, inhibited; activity, inhibited	cell cycle regulation; cell differentiation, altered; carcinogenesis, inhibited; cell growth, altered			6635; 4313611; 25227611	12	6	0	T74A/T393A mutation causes increased Cdk2 kinase activity and stability and regulation by Fbw7. ; T393A affected cyclin E abundance and associated kinase activity.  In p53 -/- cells T393A mutation increased proliferation and accelerated tumorigenesis. In p21 null cells T393A mutant caused a defect in proliferation, caused genetic instability, was more abundant, and had higher kinase activity.	
ADD2	Cytoskeletal protein; Motility/polarity/chemotaxis	P35612	119	ADD2	2p13.3	human	S697	PHOSPHORYLATION	467408	GPMSPEGsPSKSPSK			cell growth, induced; cytoskeletal reorganization			23940900	1	7	0		
CDH5	Cell adhesion; Membrane protein, integral; Motility/polarity/chemotaxis	P55284	12562	Cdh5		mouse	Y731	PHOSPHORYLATION	456049	PYDTLHIyGYEGAES	Cadherin_C		cell motility, altered			1968313	3	0	1	affects cell migration and increased endothelial cell barrier permeability	
PPP2CA	EC 3.1.3.16; Motility/polarity/chemotaxis; PHOSPHATASE; Protein phosphatase, Ser/Thr (non-receptor)	P63331	24672	Ppp2ca		rat	L309	METHYLATION	3627520	RRTPDYFl_______		molecular association, regulation		PPP2CB(DISRUPTS)		11804	6	0	0	Demethylated, phosphorylated PPP2CA decreased binding to PPP2CB.	
MAD1L1	Cell cycle regulation; Cytoskeletal protein	Q9Y6D9	8379	MAD1L1	7p22	human	T680	PHOSPHORYLATION	5024706	SKMQLLEtEFSHTVG	MAD	activity, induced; intracellular localization	cell cycle regulation			5007907	1	1	0		
PTHR	GPCR, family 2; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR	P25961	56813	Pth1r		rat	S491	PHOSPHORYLATION	452061	KRKARSGsSSYSYGP		receptor internalization, altered; activity, inhibited				8759; 2831777	3	1	0		
TRPV1	Channel, cation; Membrane protein, integral; Membrane protein, multi-pass; Receptor, misc.	Q8NER1	7442	TRPV1	17p13.2	human	Y200	PHOSPHORYLATION	458384	ASYTDSYyKGQTALH		receptor desensitization, altered; intracellular localization				7401	2	0	0		
PLCG2	Carbohydrate Metabolism - inositol phosphate; EC 3.1.4.11; Motility/polarity/chemotaxis; Phospholipase	P16885	5336	PLCG2	16q24.1	human	Y753	PHOSPHORYLATION	447940	ERDINSLyDVSRMYV		molecular association, regulation; enzymatic activity, induced		Lyn(INDUCES)		4801; 5646	7	11	294		
Cot	EC 2.7.11.25; KINASE; Kinase, protein; Protein kinase, STE; Protein kinase, Ser/Thr (non-receptor)	Q07174	26410	Map3k8		mouse	S400	PHOSPHORYLATION	447712	EDQPRCQsLDSALFE		activity, induced		ERK2(INDUCES)		1173401	2	1	0		
Cx43	Channel, misc.; Membrane protein, integral; Membrane protein, multi-pass; Motility/polarity/chemotaxis	P08050	24392	Gja1		rat	S282	PHOSPHORYLATION	448854	TAPLSPMsPPGYKLV		activity, inhibited				2192	16	1	1		
CD22	Cell surface; Membrane protein, integral	P35329	12483	Cd22		mouse	Y857	PHOSPHORYLATION	450944	QAKEDVDyVTLKH__		molecular association, regulation; phosphorylation		Syk(INDUCES); PLCG1(INDUCES); SHP-1(INDUCES); PIK3R1(INDUCES)		1172849; 3163	5	0	12		
IP3R1	Channel, calcium; Channel, ligand-gated; Membrane protein, integral; Membrane protein, multi-pass; Receptor, misc.	Q14643	3708	ITPR1	3p26.1	human	T800	PHOSPHORYLATION	450269	RDPQEQVtPVKYARL		molecular association, regulation				8582	2	0	0	T800 phosphorylation  increases IP3  binding  to IP3R1.	
PDGFRB	EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Protein kinase, TK; Protein kinase, tyrosine (receptor)	P05622	18596	Pdgfrb		mouse	Y580	PHOSPHORYLATION	447519	SDGHEYIyVDPVQLP		molecular association, regulation		PLCG1(INDUCES)		6290	6	1	0		
TTK	Cancer Testis Antigen (CTA); EC 2.7.12.1; KINASE; Kinase, protein; Protein kinase, Other; Protein kinase, dual-specificity	P33981	7272	TTK	6q13-q21	human	S742	PHOSPHORYLATION	4145509	QQIINQIsKLHAIID	Pkinase	enzymatic activity, induced				4042509	1	0	0	in vitro	
KLC1	Microtubule binding protein; Motor protein	P37285	171041	Klc1		rat	S460	PHOSPHORYLATION	477826	YKACKVDsPTVTTTL		molecular association, regulation		CLSTN1(DISRUPTS)		18711402	1	19	3		
CDH1	Cell adhesion; Membrane protein, integral; Motility/polarity/chemotaxis; UBIQUITIN LIGASE; Ubiquitin ligase	P09803	12550	Cdh1		mouse	S840	PHOSPHORYLATION	465565	LVFDYEGsGSEAASL	Cadherin_C	molecular association, regulation		CTNNB1(INDUCES)		15754200	4	1	0		
COL4A3BP	EC 2.7.11.9; KINASE; Kinase, protein; Lipid binding protein; Protein kinase, ATYPICAL; Protein kinase, Ser/Thr (non-receptor)	Q9Y5P4	10087	COL4A3BP	5q13.3	human	S132	PHOSPHORYLATION	483985	SSLRRHGsMVSLVSG	Acyl_CoA_thio	molecular association, regulation; intracellular localization; enzymatic activity, inhibited; activity, inhibited	exocytosis, altered	COL4A3BP(INDUCES)		1263901; 18410803; 6337809; 11963	5	5	9	regulates PI(4)P uptake	
BCKDH E1-alpha	Amino Acid Metabolism - valine, leucine and isoleucine degradation; EC 1.2.4.4; Lyase; Mitochondrial; Oxidoreductase	P11960	25244	Bckdha		rat	S333	PHOSPHORYLATION	449636	TYRIGHHsTSDDSSA	E1_dh	enzymatic activity, inhibited				4706	6	36	25		
IL2RB	Membrane protein, integral; Receptor, cytokine	P14784	3560	IL2RB	22q13.1	human	Y418	PHOSPHORYLATION	450884	LSGEDDAyCTFPSRD		molecular association, regulation	apoptosis, inhibited; cell growth, altered	Shb(INDUCES)		8607	3	0	0		
sarcolipin	Endoplasmic reticulum; Membrane protein, integral	P42532	100009246	SLN		rabbit	T5	PHOSPHORYLATION	459214	___MERStRELCLNF	Sarcolipin; Phospholamban	molecular association, regulation		SERCA2(INDUCES)		7689	3	0	0		
CAMK1A	EC 2.7.11.17; KINASE; Kinase, protein; Protein kinase, CAMK; Protein kinase, Ser/Thr (non-receptor)	Q63450	171503	Camk1		rat	T177	PHOSPHORYLATION	448527	DPGSVLStACGTPGY	Pkinase	molecular association, regulation		CREB(INDUCES); NUMBL(INDUCES); SYN1(INDUCES)		6681	7	2	7		
IRF3	DNA binding protein; Transcription factor	Q14653	3661	IRF3	19q13.3-q13.4	human	T135	PHOSPHORYLATION	477901	GGGSTSDtQEDILDE		protein stabilization; intracellular localization				1223900	2	13	7		
SRC-3	ACETYLTRANSFERASE; Acetyltransferase; EC 2.3.1.48; Motility/polarity/chemotaxis; Nuclear receptor co-regulator; Transcription, coactivator/corepressor	Q9Y6Q9	8202	NCOA3	20q12	human	S102	PHOSPHORYLATION	4661900	VQKADVSsTGQGVID		protein degradation	cell growth, altered			4641435	2	0	0		
FPR2	GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Motility/polarity/chemotaxis; Receptor, GPCR	P25090	2358	FPR2	19q13.3-q13.4	human	S237	PHOSPHORYLATION	3176602	KKGMIKSsRPLRVLT	7tm_1	receptor desensitization, altered				8619	1	0	0	downregulates PLA2 and PLD activation	
POLR2A	EC 2.7.7.48; EC 2.7.7.6; Nucleotide Metabolism - purine; Nucleotide Metabolism - pyrimidine; Transcription initiation complex; Transferase	P08775	20020	Polr2a		mouse	S1616	PHOSPHORYLATION	450204	TPQSPSYsPTSPSYS	RNA_pol_Rpb1_R	intracellular localization; enzymatic activity, induced	transcription, induced			21655803; 3342609	53	0	0		
Nur77	Apoptosis; DNA binding protein; Nuclear receptor	P22829	79240	Nr4a1		rat	S350	PHOSPHORYLATION	447942	GRRGRLPsKPKQPPD		molecular association, regulation	apoptosis, inhibited	14-3-3 beta(INDUCES)	DNA(INDUCES)	1335; 2466206	7	2	0		
SPHK1	EC 2.7.1.-; EC 2.7.1.91; KINASE; Kinase, lipid; Lipid Metabolism - sphingolipid	Q9NYA1	8877	SPHK1	17q25.2	human	S225	PHOSPHORYLATION	460682	VGSKTPAsPVVVQQG		molecular association, regulation; intracellular localization; phosphorylation; enzymatic activity, induced	carcinogenesis, altered; apoptosis, inhibited; cell growth, altered	ITGB3(INDUCES); PECAM-1(INDUCES)	Other(INDUCES)	7801; 8793; 8813; 17482916; 11270006; 5007908	10	6	0		
AID	EC 3.5.4.5; Hydrolase	Q9WVE0	11628	Aicda		mouse	T27	PHOSPHORYLATION	471423	WAKGRHEtYLCYVVK	APOBEC_N	molecular association, regulation; enzymatic activity, induced	chromatin organization, altered	RPA1(INDUCES)		970024; 7195	5	2	0	promotes deamination of transcribed dsDNA substrates in B cells; Mutation of either site significantly decreases  gene conversion (GCV) & somatic hypermutation (SHM) frequency.	
MyoD	DNA binding protein; RNA splicing; Transcription factor	P10085	17927	Myod1		mouse	S200	PHOSPHORYLATION	452000	SGDSDASsPRSNCSD	Myf5	protein degradation; molecular association, regulation; intracellular localization	cell cycle regulation; transcription, altered	HDAC1(INDUCES); PCAF(DISRUPTS)	DNA(DISRUPTS)	3910; 8938; 8661; 4002	6	0	0		
MYH9	Actin binding protein; Motility/polarity/chemotaxis; Motor protein	P35579	4627	MYH9	22q13.1	human	S1808	PHOSPHORYLATION	2482304	VKSKYKAsITALEAK	Myosin_tail_1; AAA_13	intracellular localization	cytoskeletal reorganization			2451809	1	1	0		
MLL5	Cell cycle regulation; EC 2.1.1.43; Methyltransferase; Methyltransferase, protein lysine; Transcription, coactivator/corepressor	Q8IZD2	55904	MLL5	7q22.1	human	T912	PHOSPHORYLATION	14645300	PMDPSFAtPPRIKSD		intracellular localization	cell cycle regulation			14551408	1	0	2		
DVL2	Adaptor/scaffold; Motility/polarity/chemotaxis	O14641	1856	DVL2	17p13.1	human	Y18	PHOSPHORYLATION	12170303	VGETKVIyHLDEEET	DIX		transcription, induced			12021336	1	1	0	regulates Wnt3a/beta-catenin signaling 	
AT1	GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR	P29754	11607	Agtr1a		mouse	Y319	PHOSPHORYLATION	448745	YFLQLLKyIPPKAKS		activity, induced				8282	5	0	0	Transgenic mice with cardiac-specific overexpression of Y319F mutant AT1 have reduced EGFR activation, and do not develop cardiac hypertrophy, fibrosis or apoptosis	
LPP	Adaptor/scaffold; Cytoskeletal protein; Motility/polarity/chemotaxis	Q8BFW7	210126	Lpp		mouse	Y318	PHOSPHORYLATION	448947	RSEGDTAyGQQVQPN			cell cycle regulation; cell motility, altered			2790302	1	10	273		
E2A	DNA binding protein; Transcription factor	P15923	6929	TCF3	19p13.3	human	S379	PHOSPHORYLATION	3180968	AGAPGALsPSYDGGL		activity, inhibited	transcription, inhibited			10353939	1	13	15		
acinus	Apoptosis; RNA splicing; Spliceosome	E9PST5	305884	Acin1		rat	S1180	PHOSPHORYLATION	456759	GPRSRSRsRDRRRKE		protein stabilization				6835	3	2	0	S1180 phosphorylation prevents proteolytic degradation of acinus and blocks chromatin condensation in vivo and in vitro  
	
ARHGEF2	Guanine nucleotide exchange factor, Rac/Rho; Motility/polarity/chemotaxis	Q92974	9181	ARHGEF2	1q21-q22	human	S886	PHOSPHORYLATION	451365	PVDPRRRsLPAGDAL		molecular association, regulation; phosphorylation	cytoskeletal reorganization	14-3-3 beta(INDUCES)		3572; 7093	7	19	130	Mutant S810A  showed an accumulation of disorganized stress fibers compared to untransfected cells. Increased activation of Rho was seen with the S810A mutation. Co-transfection of S885A with PAK4-S474E showes a perfusion of  stress fibers and labeled protein at periferal sites. 	
ARHGAP3	GTPase activating protein, Rac/Rho	P52757	1124	CHN2	7p15.3	human	Y153	PHOSPHORYLATION	473503	KMTTNPIyEHIGYAT		intracellular localization; activity, inhibited	cytoskeletal reorganization			6804204	1	2	144		
QIK	EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, CAMK; Protein kinase, Ser/Thr (non-receptor)	Q8CFH6	235344	Sik2		mouse	S358	PHOSPHORYLATION	487501	DGRQRRPsTIAEQTV		enzymatic activity, induced				12291	2	3	110		
GPIbA	Cell adhesion; Cell surface; Membrane protein, integral	P07359	2811	GP1BA	17pter-p12	human	S575	PHOSPHORYLATION	11333102	WLLFLRGsLPTFRSS		molecular association, regulation		FLNA(DISRUPTS); 14-3-3 zeta(INDUCES); VWF(INDUCES)		11270003	1	0	0		
ELF4	DNA binding protein; Transcription factor	Q99607	2000	ELF4	Xq26	human	T643	PHOSPHORYLATION	463813	SLLTRSPtPAPFSPF		protein degradation				7869	1	1	1		
STIM1	Calcium-binding protein; Endoplasmic reticulum; Membrane protein, integral	Q13586	6786	STIM1	11p15.5	human	S628	PHOSPHORYLATION	9257903	SPDPDTPsPVGDSRA		molecular association, regulation; intracellular localization	cytoskeletal reorganization	EB1(DISRUPTS)		25712651	1	3	4	Phosphorylation dissociates STIM1 from EB1 during mtosis, and excludes ER from the mitotic spindle.	
MLK1	EC 2.7.11.25; KINASE; Kinase, protein; Protein kinase, Ser/Thr (non-receptor); Protein kinase, TKL	P80192	4293	MAP3K9	14q24.2	human	T312	PHOSPHORYLATION	455217	TKMSAAGtYAWMAPE	Pkinase_Tyr	activity, induced				4352	1	0	0		
IRF7	DNA binding protein; Transcription factor	P70434	54123	Irf7		mouse	S437	PHOSPHORYLATION	486437	SSLGLCLsSTNSLYE			transcription, induced		DNA(INDUCES)	12173	2	0	0		
MRLC2	Contractile protein	P18666	50685	Myl12b		rat	T19	PHOSPHORYLATION	448596	KKRPQRAtSNVFAMF	EF_hand_5	protein conformation	exocytosis, altered			4214821	31	23	266		
PDE6G	EC 3.1.4.17; EC 3.1.4.35; Nucleotide Metabolism - purine; Phosphodiesterase	P04972	281977	PDE6G		cow	T22	PHOSPHORYLATION	449334	RVMGGPVtPRKGPPK	PDE6_gamma	phosphorylation				11270018	5	1	5	mutation of this site attenuates basal PDE6G phosphorylation at T35 	
TBCB	Chaperone; Cytoskeletal protein; Motility/polarity/chemotaxis	Q99426	1155	TBCB	19q13.11-q13.12	human	S128	PHOSPHORYLATION	455785	VRSFLKRsKLGRYNE	PAPA-1		cytoskeletal reorganization			5800; 1172870	2	0	0		
Jun	Transcription factor	P05412	3725	JUN	1p32-p31	human	S249	PHOSPHORYLATION	455367	LSPIDMEsQERIKAE	DUF3450; HAP1_N; Jnk-SapK_ap_N; Seryl_tRNA_N	molecular association, regulation; activity, inhibited	transcription, altered	SP1(DISRUPTS)		4702; 2713706	3	0	1		
tau	Cytoskeletal protein	P10637	17762	Mapt		mouse	S701	PHOSPHORYLATION	449132	DTSPRHLsNVSSTGS		molecular association, regulation		AKAP5(INDUCES); PKAR2B(INDUCES); PKACB(INDUCES)		2889	11	8	5		
Abl	EC 2.7.1.112; EC 2.7.10.2; KINASE; Kinase, protein; Protein kinase, TK; Protein kinase, tyrosine (non-receptor)	P00519	25	ABL1	9q34.1	human	T735	PHOSPHORYLATION	450291	DTEWRSVtLPRDLQS		molecular association, regulation; intracellular localization; enzymatic activity, induced	apoptosis, induced; apoptosis, inhibited	14-3-3 beta(INDUCES)		9721203; 5307; 6115910	5	0	1		
PPP1CA	EC 3.1.3.16; PHOSPHATASE; Protein phosphatase, Ser/Thr (non-receptor)	P62136	5499	PPP1CA	11q13	human	T320	PHOSPHORYLATION	448686	NPGGRPItPPRNSAK		activity, inhibited	cell differentiation, altered			2670101; 6000	19	23	82		
DOR-1	GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR	P32300	18386	Oprd1		mouse	S363	PHOSPHORYLATION	448550	RVTACTPsDGPGGGA		receptor desensitization, altered; intracellular localization; receptor internalization, altered				18119118; 2306	10	1	0		
Bcl-11B	C2H2-type zinc finger protein; Nuclear receptor co-regulator	Q99PV8	58208	Bcl11b		mouse	S277	PHOSPHORYLATION	14159419	GPETVAQsPLMNFLG		molecular association, regulation		SENP1(INDUCES)		25573548	0	2	1		
ADORA2A	GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR	P29274	135	ADORA2A	22q11.23	human	S374	PHOSPHORYLATION	13417800	SGGSAQEsQGNTGLP		molecular association, regulation		DRD2(INDUCES)		13358803	1	0	0		
MDM2	EC 6.3.2.-; EC 6.3.2.19; Inhibitor protein; Ligase; UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase	Q00987	4193	MDM2	12q14.3-q15	human	S386	PHOSPHORYLATION	11956709	DDKITQAsQSQESED		molecular association, regulation; ubiquitination		MDM2(DISRUPTS)		11387267	3	2	0	phospho-mimic mutant is defective for p53 poly-ubiquitination	
nAChRB1	Channel, cation; Channel, ligand-gated; Membrane protein, integral; Membrane protein, multi-pass	P09690	11443	Chrnb1		mouse	Y390	PHOSPHORYLATION	2562301	WGRGTDEyFIRKPPS	Neur_chan_memb	molecular association, regulation		RAPSN(INDUCES)		5358600	2	0	3	increases nAchRB1 clustering	
vimentin	Cytoskeletal protein; Motility/polarity/chemotaxis	P20152	22352	Vim		mouse	S72	PHOSPHORYLATION	449026	SSAVRLRsSVPGVRL	Filament_head; DUF2464		cytoskeletal reorganization			2057	12	13	39		
PECAM-1	Cell adhesion; Membrane protein, integral	P16284	5175	PECAM1	17q23.3	human	Y690	PHOSPHORYLATION	448759	PLNSDVQyTEVQVSS		activity, induced; molecular association, regulation	cytoskeletal reorganization; cell adhesion, altered	SHP-2(INDUCES)		1928; 8502; 3534; 3921; 3914	8	0	44		
separase	EC 3.4.22.49; Protease	P60330	105988	Espl1		mouse	S1121	PHOSPHORYLATION	447673	IQSSVNSsPVLKTKP			cell growth, altered			1968354	8	6	0	S1121A mutation in mice results in proliferation failure in germ cells (premature sister chromatid separation, mitotic arrest and aneuploidy)	
PLK4	EC 2.7.11.21; KINASE; Kinase, protein; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor)	Q64702	20873	Plk4		mouse	S297	PHOSPHORYLATION	12654005	LSTTITAsSGTSLSG		protein degradation; ubiquitination				12525201	1	1	0		
VAV1	Guanine nucleotide exchange factor, Rac/Rho; Motility/polarity/chemotaxis	P15498	7409	VAV1	19p13.2	human	Y844	PHOSPHORYLATION	454086	VEEDYSEyC______			carcinogenesis, altered; cell growth, altered			14551403	1	9	459		
FOXC2	Apoptosis; Cell development/differentiation; DNA binding protein; Transcription factor	Q99958	2303	FOXC2	16q24.1	human	S251	PHOSPHORYLATION	7322587	AASTPAGsPDGSLPE		molecular association, regulation	transcription, altered		DNA(INDUCES)	28129300	1	1	0	implicated in vascular remodeling  in vivo	
SKI	Cell cycle regulation; Transcription, coactivator/corepressor; Ubiquitin conjugating system	P12755	6497	SKI	1p36.33	human	T458	PHOSPHORYLATION	11279400	QPRKRKLtVDTPGAP		protein degradation	transcription, altered			11189924	1	0	1	reduces the activation of TGF-beta signaling	
LKB1	Autophagy; EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, CAMK; Protein kinase, Ser/Thr (non-receptor)	Q9WTK7	20869	Stk11		mouse	Y365	PHOSPHORYLATION	13258701	DIEDGIIyTQDFTVP		intracellular localization; phosphorylation				12775501	2	0	0	mutation of this site increses AMPK phosphorylation	
BRCA1	EC 6.3.2.-; Nuclear receptor co-regulator; Transcription, coactivator/corepressor; Tumor suppressor; UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase	P38398	672	BRCA1	17q21	human	S1280	PHOSPHORYLATION	767901	QVILAKAsQEHHLSE		intracellular localization				762701	1	1	0	S1143 and S1280 phosphorylation contributes to BRCA1 recruitment to MMTS-induced foci. 	
ERK5	EC 2.7.11.24; KINASE; Kinase, protein; Protein kinase, CMGC; Protein kinase, Ser/Thr (non-receptor)	Q13164	5598	MAPK7	17p11.2	human	Y221	PHOSPHORYLATION	448206	HQYFMTEyVATRWYR	Pkinase		apoptosis, inhibited			15031301	12	14	960		
PAX6	DNA binding protein; Motility/polarity/chemotaxis; Transcription factor	P63015	18508	Pax6		mouse	T281	PHOSPHORYLATION	458808	QRRQASNtPSHIPIS			transcription, induced			7464	1	0	0		
NRF2	DNA binding protein; Transcription factor	Q16236	4780	NFE2L2	2q31	human	S558	PHOSPHORYLATION	10292703	HLLKKQLsTLYLEVF	bZIP_1	intracellular localization	transcription, induced			9983602	1	1	0	moderate effects observed only in NFE2L2-5A mutant	
HMGA2	DNA binding protein	P52927	15364	Hmga2		mouse	S59	PHOSPHORYLATION	11452900	PKGSKNKsPSKAAQK		molecular association, regulation; protein conformation			DNA(DISRUPTS)	10292901	1	0	0		
PKCT	EC 2.7.11.13; KINASE; Kinase, protein; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor)	Q04759	5588	PRKCQ	10p15	human	T219	PHOSPHORYLATION	457380	SAINSREtMFHKERF		intracellular localization				6963	1	1	0	phosphorylation of site may be important in antigen receptor-mediated signaling 	
PDE4D iso2	EC 3.1.4.17; Nucleotide Metabolism - purine; Phosphodiesterase	Q08499-2	5144	PDE4D	5q12	human	S12	PHOSPHORYLATION	2188800	NNFFRRHsWICFDVD		molecular association, regulation		NDEL1(DISRUPTS); AKAP6(INDUCES)		5014008; 4149	4	0	0		
GFAP	Cytoskeletal protein	P03995	14580	Gfap		mouse	S8	PHOSPHORYLATION	449618	MERRRITsARRSYAS	Filament_head	molecular association, regulation		14-3-3 gamma(INDUCES)		9022	8	0	0		
TCF7L2	Apoptosis; Cell cycle regulation; Cell development/differentiation; DNA binding protein; Motility/polarity/chemotaxis; Transcription factor	Q9NQB0	6934	TCF7L2	10q25.3	human	T212	PHOSPHORYLATION	11499002	TYSNEHFtPGNPPPH	CTNNB1_binding	molecular association, regulation			DNA(DISRUPTS)	10294002	1	0	0	Beta-catenin-TCF7L2 complex DNA binding	
BACE	EC 3.4.23.46; Membrane protein, integral; Protease	P56817	23621	BACE1	11q23.2-q23.3	human	S498	PHOSPHORYLATION	450178	DDFADDIsLLK____		intracellular localization				5220; 2806	4	4	0		
WAVE2	Actin binding protein; Motility/polarity/chemotaxis	Q9Y6W5	10163	WASF2	1p36.11	human	S308	PHOSPHORYLATION	12626400	PPAPPLGsPPGPKPG		molecular association, regulation	cell motility, altered; cytoskeletal reorganization			18668222	1	5	0	regulates WRC (WAVE2 regulatory complex) interaction with Arp2/3 and lamellipodial protrusion	
PSF	Nuclear receptor co-regulator; RNA binding protein; RNA splicing	P23246	6421	SFPQ	1p34.3	human	T687	PHOSPHORYLATION	449362	PRGMGPGtPAGYGRG		molecular association, regulation		BCLAF1(INDUCES); Trap150(INDUCES)		17722101	1	14	53	TRAP150-PSF interaction regulates CD45 splicing by blocking PSF from interacting with CD45 pre-mRNA in resting T cells	
CBY1	Transcription regulation	Q9Y3M2	25776	CBY1	22q12	human	S20	PHOSPHORYLATION	2850009	TPPRKSAsLSNLHSL		molecular association, regulation; intracellular localization	transcription, altered	14-3-3 zeta(INDUCES)		2831779	1	6	0	interaction of PGEA1 with 14-3-3 zeta contributes to the formation of trimolecular complex with CTNNB1 	
14-3-3 beta	Adaptor/scaffold	P35213	56011	Ywhab		rat	T143	PHOSPHORYLATION	3136106	SGDNKQTtVSNSQQA	14-3-3	molecular association, regulation		RAF1(DISRUPTS); PKCZ(DISRUPTS)		8741	1	0	0		
eIF6	Translation; Translation initiation	P56537	3692	EIF6	20q12	human	S235	PHOSPHORYLATION	450271	QPSTIATsMRDSLID		molecular association, regulation	translation, altered		Other(DISRUPTS)	2976	3	2	2	release from 60S ribosomal subunit	
Shc1 iso2	Adaptor/scaffold; Apoptosis; Mitochondrial; Motility/polarity/chemotaxis	P29353-2	6464	SHC1	1q21	human	Y239	PHOSPHORYLATION	448509	EEPPDHQyYNDFPGK		activity, induced; molecular association, regulation; phosphorylation	cell motility, altered; cytoskeletal reorganization	SHIP(INDUCES); ZAP70(INDUCES); VAV1(INDUCES); Grb2(INDUCES)		762700; 8804; 783; 8168	27	15	922	f-actin cytoskeleton, chemotaxis.; promotes Shc phosphorylation	
MybBP1A	DNA binding protein; DNA replication	Q9BQG0	10514	MYBBP1A	17p13.3	human	S1303	PHOSPHORYLATION	3210687	ARKKARLsLVIRSPS			cell cycle regulation			12778821	2	11	2		
TTP	DNA binding protein; RNA binding protein	P22893	22695	Zfp36		mouse	S52	PHOSPHORYLATION	451150	RLTGRSTsLVEGRSC		molecular association, regulation; protein stabilization; intracellular localization; activity, inhibited	translation, altered	14-3-3 beta(INDUCES); CAF-1A(DISRUPTS); CAF-1B(DISRUPTS)		15022710; 7769; 8864	5	6	0		
CNR1	GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR	P47746	12801	Cnr1		mouse	S469	PHOSPHORYLATION	22342303	MSVSTDTsAEAL___		receptor desensitization, induced				21686207	1	0	0		
PKD1	Autophagy; EC 2.7.11.13; KINASE; Kinase, protein; Motility/polarity/chemotaxis; Protein kinase, CAMK; Protein kinase, Ser/Thr (non-receptor)	Q15139	5587	PRKD1	14q11	human	S208	PHOSPHORYLATION	455754	RRRLSNVsLTGVSTI		molecular association, regulation		14-3-3 beta(INDUCES)		5785	2	12	9		
SLP76	Adaptor/scaffold	Q60787	16822	Lcp2		mouse	Y128	PHOSPHORYLATION	448219	DGEDDGDyESPNEEE		molecular association, regulation; phosphorylation	cell differentiation, altered; apoptosis, altered; cytoskeletal reorganization; cell adhesion, altered; transcription, induced; transcription, altered	VAV1(INDUCES)		2425220; 1967701; 2079; 1605; 1606; 6115903	17	0	0	mutation of this site impairs thrombus formation	
BRSK2	EC 2.7.11.1; EC 2.7.11.26; KINASE; Kinase, protein; Protein kinase, CAMK; Protein kinase, Ser/Thr (non-receptor)	Q8IWQ3	9024	BRSK2	11p15.5	human	T260	PHOSPHORYLATION	470033	VDAARRLtLEHIQKH	Pkinase	enzymatic activity, induced				8952	2	0	0		
CTNNB1	Actin binding protein; Cell adhesion; Motility/polarity/chemotaxis; Nuclear receptor co-regulator; Transcription factor	Q9WU82	84353	Ctnnb1		rat	S45	PHOSPHORYLATION	447488	GATTTAPsLSGKGNP		protein degradation				3803	21	5	0		
HIPK2	EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, CMGC; Protein kinase, Ser/Thr (non-receptor)	Q9H2X6	28996	HIPK2	7q32-q34	human	K32	UBIQUITINATION	3059900	FCSVKKLkIEPSSNW		protein degradation				2831762	1	0	0		
FOXK2	DNA binding protein; Transcription factor	Q01167	3607	FOXK2	17q25	human	S373	PHOSPHORYLATION	3193955	SSRSAPAsPNHAGVL		protein stabilization	apoptosis, altered; transcription, altered			15562511	1	6	26		
MEF2D	DNA binding protein; Transcription factor	O89038	81518	Mef2d		rat	S153	PHOSPHORYLATION	10359102	VPVSNQSsMQFSNPS	HJURP_C	activity, inhibited	apoptosis, altered; transcription, inhibited			10353938	1	0	0		
JunB	Motility/polarity/chemotaxis; Transcription factor	P17275	3726	JUNB	19p13.2	human	S79	PHOSPHORYLATION	454237	QGSDTGAsLKLASSE	Jun	activity, induced	transcription, altered	p300(INDUCES)		4237	2	0	0		
CTPS	EC 6.3.4.2; Ligase; Motility/polarity/chemotaxis; Nucleotide Metabolism - pyrimidine	P17812	1503	CTPS1	1p34.1	human	T455	PHOSPHORYLATION	473570	MRLGKRRtLFQTKNS	GATase	enzymatic activity, inhibited	cell growth, altered			11469; 9163	2	0	0		
LKB1 iso2	Autophagy; EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, CAMK; Protein kinase, Ser/Thr (non-receptor)	Q15831-2	6794	STK11	19p13.3	human	S399	PHOSPHORYLATION	27933602	DLSGEEAsRPAPQ__		intracellular localization; enzymatic activity, induced				27902353	1	0	0	S399 is required for metformin activation of AMPK.; translocation from nucleus to cytosol	
H1R	GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR	P35367	3269	HRH1	3p25	human	S398	PHOSPHORYLATION	450937	WKRLRSHsRQYVSGL	7tm_1	receptor desensitization, altered; receptor internalization, altered				3150; 4674; 4121	3	0	0		
PSRC1	Tumor suppressor	Q6PGN9	84722	PSRC1	1p13.3	human	S223	PHOSPHORYLATION	18963101	RAAKLRVsGSGEFVG			cytoskeletal reorganization			18898704	1	1	0		
Kir4.1	Channel, ligand-gated; Channel, potassium; Membrane protein, integral; Membrane protein, multi-pass	P49655	29718	Kcnj10		rat	S377	PHOSPHORYLATION	2243103	SALSVRIsNV_____		molecular association, regulation; intracellular localization		MAGI1(DISRUPTS)		2195473	1	1	0		
DBN1	Actin binding protein; Cytoskeletal protein; Motility/polarity/chemotaxis	Q16643	1627	DBN1	5q35.3	human	S142	PHOSPHORYLATION	452446	NGLARLSsPVLHRLR		molecular association, regulation	cytoskeletal reorganization	EB3(INDUCES); ACTB(INDUCES)		28722154	1	43	26	regulates F-actin bundling, relieves the intramolecular inhibition of F-actin bundling, bound to F-actin bundles in filopodia,  important for neuritogenesis, iimportant for microtubule? F-actin interactions.	
SIAH2	EC 6.3.2.-; EC 6.3.2.19; Ligase; Transcription, coactivator/corepressor; UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase	O43255	6478	SIAH2	3q25	human	T119	PHOSPHORYLATION	26371004	PTCRGALtPSIRNLA		protein degradation; intracellular localization; enzymatic activity, induced	cytoskeletal reorganization			26341714	2	2	0		
DAB1 iso2	Adaptor/scaffold	P97318-2	13131	Dab1		mouse	S481	PHOSPHORYLATION	479420	STTPSTNsPPTPAPR		phosphorylation				11449	1	0	0	inhibits tyrosine phosphorylation	
axin 1	Adaptor/scaffold	O70239	79257	Axin1		rat	S325	PHOSPHORYLATION	2226510	ANDSEQQsLSSDADT			cytoskeletal reorganization			25797201	1	0	0	Phosphorylation regulates responsive to Sema3A induced growth cone collapse.	
BRSK2	EC 2.7.11.1; EC 2.7.11.26; KINASE; Kinase, protein; Protein kinase, CAMK; Protein kinase, Ser/Thr (non-receptor)	Q8IWQ3	9024	BRSK2	11p15.5	human	T443	PHOSPHORYLATION	17551641	PRGSPLPtPKGTPVH		enzymatic activity, inhibited				27902363	2	2	0		
DUSP8	EC 3.1.3.16; EC 3.1.3.48; Motility/polarity/chemotaxis; Protein phosphatase, dual-specificity	O09112	18218	Dusp8		mouse	S515	PHOSPHORYLATION	22598803	GWVPPLDsPGTPSPD		enzymatic activity, inhibited	signaling pathway regulation			22495309	1	1	0	activates JNK pathway	
HePTP	EC 3.1.3.48; Motility/polarity/chemotaxis; PHOSPHATASE; Protein phosphatase, tyrosine (non-receptor)	P35236	5778	PTPN7	1q32.1	human	S246	PHOSPHORYLATION	460715	QYQEERRsVKHILFS	Y_phosphatase	intracellular localization; enzymatic activity, induced				7787	1	0	0	inhibits TCR-induced gene activation	
DAT	Membrane protein, integral; Membrane protein, multi-pass; Transporter	Q01959	6531	SLC6A3	5p15.3	human	S13	PHOSPHORYLATION	451138	CSVGLMSsVVAPAKE		activity, induced				8183	4	0	0	stimulates DAT-mediated efflux of dopamine	
Ret	EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Protein kinase, TK; Protein kinase, tyrosine (receptor)	P07949	5979	RET	10q11.2	human	S696	PHOSPHORYLATION	451267	SSGARRPsLDSMENQ		molecular association, regulation; enzymatic activity, induced	cytoskeletal reorganization			15235208; 3487	5	3	0	regulation of Rac activation and GDNF induced lamellipodia formation.; inhibits interaction of SHP2 with Ret Y687	
PXR	DNA binding protein; Nuclear receptor	O75469	8856	NR1I2	3q12-q13.3	human	T408	PHOSPHORYLATION	9730704	RSINAQHtQRLLRIQ	Hormone_recep	molecular association, regulation; intracellular localization	transcription, altered	N-CoR1(DISRUPTS); Fgr(INDUCES); RXRA(DISRUPTS)		9689411	2	0	0	inhibits transcription	
SCN5A	Channel, sodium; Membrane protein, integral; Membrane protein, multi-pass	Q14524	6331	SCN5A	3p21	human	T594	PHOSPHORYLATION	25244201	LHGKKNStVDCNGVV	DUF3451	activity, inhibited				25227646	1	0	0		
SLC12A3	Membrane protein, integral; Membrane protein, multi-pass; Transporter	P55018	54300	Slc12a3		rat	T53	PHOSPHORYLATION	469616	GSTLYLRtFGYNTID	AA_permease_N	activity, induced; intracellular localization				27132423; 14562604	14	3	0		
SH3GLB1	Apoptosis; Autophagy; EC 2.3.1.-; Mitochondrial; Transferase	Q9JK48	54673	Sh3glb1		mouse	T145	PHOSPHORYLATION	26318403	TSALNFLtPLRNFIE	BAR	molecular association, regulation; protein conformation	autophagy, induced	beclin 1(INDUCES); UVRAG(INDUCES)		25779902	1	0	0	dimerization;  neuronal cell loss	
SPAG5	Cell cycle regulation	Q96R06	10615	SPAG5	17q11.2	human	T978	PHOSPHORYLATION	1261101	AEMSIMTtELQSLCS		intracellular localization				1172873	1	0	0	required for SPAG5 localization to the spindle apparatus during mitosis	
RAF1	EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, Ser/Thr (non-receptor); Protein kinase, TKL	P04049	5894	RAF1	3p25	human	S494	PHOSPHORYLATION	447745	FGLATVKsRWSGSQQ	Pkinase_Tyr	enzymatic activity, induced				6052; 5121526; 1253	5	0	0		
caldesmon	Actin binding protein	Q05682	800	CALD1	7q33	human	S744	PHOSPHORYLATION	456707	GLKVGVSsRINEWLT	Caldesmon		cell motility, altered; cytoskeletal reorganization			12778807; 8076	5	1	0		
RYR1	Channel, calcium; Membrane protein, integral; Membrane protein, multi-pass	P11716	100009540	RYR1		rabbit	S2843	PHOSPHORYLATION	451818	KKKTRKIsQTAQTYD		molecular association, regulation		CAMK2B(INDUCES)		25722202	6	6	0	20% reduction in binding with S2843A mutant	
AR	DNA binding protein; Nuclear receptor; Transcription factor	P10275	367	AR	Xq12	human	Y363	PHOSPHORYLATION	478251	AYQSRDYyNFPLALA	Androgen_recep		transcription, induced; cell growth, altered			11423	1	2	0		
HER3	EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Protein kinase, TK; Protein kinase, tyrosine (receptor)	P21860	2065	ERBB3	12q13	human	Y1262	PHOSPHORYLATION	3971613	TPDEDYEyMNRQRDG		molecular association, regulation		GRB7(INDUCES); Grb2(INDUCES)		10144208	1	1	2	Grb2 binding is reduced campared with Grb7.	
JAK2	EC 2.7.10.2; KINASE; Kinase, protein; Protein kinase, TK; Protein kinase, tyrosine (non-receptor)	Q62120	16452	Jak2		mouse	S523	PHOSPHORYLATION	465671	GISDVQIsPTLQRHN		enzymatic activity, inhibited; phosphorylation				7601401; 8089; 8083	4	11	1		
syndecan-4	Cell adhesion; Membrane protein, integral; Motility/polarity/chemotaxis	P34901	24771	Sdc4		rat	S183	PHOSPHORYLATION	449863	MKKKDEGsYDLGKKP	Syndecan; Herpes_gE; Glycophorin_A	protein conformation	cell adhesion, induced; cell motility, inhibited			7295; 25723401	6	0	0	decreased Rho A activation	
GLP1R	GPCR, family 2; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR	P32301	25051	Glp1r		rat	S442	PHOSPHORYLATION	451371	PLKCPTSsVSSGATV		receptor desensitization, altered				3574	1	0	0		
Ikaros	C2H2-type zinc finger protein; DNA binding protein; Transcription factor	Q13422	10320	IKZF1	7p13-p11.1	human	S364	PHOSPHORYLATION	4714822	GTPRSNHsAQDSAVE		molecular association, regulation; intracellular localization	cell differentiation, induced; transcription, induced		DNA(INDUCES)	27132479	1	4	0	 induces transcription of DNAJC6, EIF4e3, TNFAIP8L2; nuclear localization	
USF1	DNA binding protein; Transcription factor	P22415	7391	USF1	1q22-q23	human	K199	ACETYLATION	7652100	PRTTRDEkRRAQHNE		molecular association, regulation	transcription, inhibited		DNA(INDUCES)	7543524	1	0	0		
JAK2	EC 2.7.10.2; KINASE; Kinase, protein; Protein kinase, TK; Protein kinase, tyrosine (non-receptor)	Q62120	16452	Jak2		mouse	Y1008	PHOSPHORYLATION	448408	LPQDKEYyKVKEPGE	Pkinase_Tyr	enzymatic activity, induced				8089; 8083; 13354701; 1713155	44	1	16		
HIR	Channel, potassium; Membrane protein, integral; Membrane protein, multi-pass	P52190	116649	Kcnj4		rat	S444	PHOSPHORYLATION	9819904	NISYRREsAI_____		molecular association, regulation		TAX1BP3(DISRUPTS)		9721213	1	0	0		
ZAP70	EC 2.7.10.2; KINASE; Kinase, protein; Protein kinase, TK; Protein kinase, tyrosine (non-receptor)	P43403	7535	ZAP70	2q12	human	Y474	PHOSPHORYLATION	455368	VLLVNRHyAKISDFG	Pkinase_Tyr	activity, induced; molecular association, regulation		Shc1(INDUCES)		4703	1	0	3		
TOPORS	Cell cycle regulation; EC 6.3.2.-; EC 6.3.2.19; Ligase; UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase	Q9NS56	10210	TOPORS	9p21	human	S718	PHOSPHORYLATION	5938002	KDRDGYEsSYRRRTL		sumoylation; ubiquitination				7657701	2	1	0	inhibits sumoylation but induces ubiquitination of p53	
Abi-1	Adaptor/scaffold; Motility/polarity/chemotaxis	Q8IZP0	10006	ABI1	10p11.2	human	S410	PHOSPHORYLATION	12626407	DIPMFDDsPPPPPPP		molecular association, regulation	cell motility, altered; cytoskeletal reorganization			18668222	1	1	0	regulates WRC (WAVE2 regulatory complex) interaction with Arp2/3 and lamellipodial protrusion	
uPA	EC 3.4.21.73; Motility/polarity/chemotaxis; Protease; Secreted; Secreted, signal peptide	P00749	5328	PLAU	10q22.2	human	S158	PHOSPHORYLATION	451052	CADGKKPsSPPEELK		molecular association, regulation; intracellular localization; activity, inhibited	cell motility, altered; cell adhesion, altered; cytoskeletal reorganization	ITGA5(INDUCES); ITGB5(INDUCES)		3280; 12482216; 5014006	3	0	0	reduces ITGB5/ITGA5 activation and its interaction with vitronectin and talin; S158 phosphorylation confers to prourokinase the antagonistic properties; ligand-dependent uPA redistribution severely impaired in a S158/323E mutant	
EphB2	EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Protein kinase, TK; Protein kinase, tyrosine (receptor)	P54763	13844	Ephb2		mouse	Y750	PHOSPHORYLATION	448330	KYLADMNyVHRDLAA	Pkinase_Tyr	protein conformation				8957	3	3	1	modulates conformation of the activation section of EphB2 (residues Y604-Y610)	
RAF1	EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, Ser/Thr (non-receptor); Protein kinase, TKL	P05625	396245	RAF1		chicken	Y340	PHOSPHORYLATION	447749	RGQRDSSyYWEIEAS		enzymatic activity, induced	apoptosis, inhibited			2941; 5487	23	1	1		
PAR1	Cell development/differentiation; GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR	P25116	2149	F2R	5q13	human	S392	PHOSPHORYLATION	3627503	ILCCKESsDPSSYNS		receptor desensitization, altered				4656	1	0	0	receptor shutoff (not internalization)	
ERK2	EC 2.7.11.24; KINASE; Kinase, protein; Protein kinase, CMGC; Protein kinase, Ser/Thr (non-receptor)	P63086	116590	Mapk1		rat	T179	PHOSPHORYLATION	3189583	ADPDHDHtGFLTEYV	Pkinase; YukC	enzymatic activity, induced	translation, altered			5955619	3	7	34	 phenylphrine induces protein synthesis	
PACT	Activator protein; RNA binding protein; RNA processing	Q9WTX2	23992	Prkra		mouse	S18	PHOSPHORYLATION	453415	PPLQREDsGTFSLGK		molecular association, regulation; phosphorylation	translation, altered; apoptosis, induced	PKR(INDUCES)		7728; 4134	3	33	111		
ENOX2	Cell surface; Cytoskeletal protein; EC 1.-.-.-; Oxidoreductase	Q16206	10495	ENOX2	Xq25	human	S504	PHOSPHORYLATION	25602101	ENLKEKEsCASRLCA		protein stabilization	cell motility, induced; cell growth, induced			25582507	1	0	0		
MDM2	EC 6.3.2.-; EC 6.3.2.19; Inhibitor protein; Ligase; UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase	Q00987	4193	MDM2	12q14.3-q15	human	S242	PHOSPHORYLATION	454921	WLDQDSVsDQFSVEF		activity, induced				4379	3	1	0	promotes p53 degradation	
SSTR2	GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR	P30680		Sstr2		rat	T353	PHOSPHORYLATION	7652102	DKSRLNEtTETQRTL		receptor internalization, altered				18716600	7	0	1		
ABCF1	Translation	Q8NE71	23	ABCF1	6p21.33	human	S140	PHOSPHORYLATION	454452	AALIQDQsEEEEEEE	ABC_tran	molecular association, regulation				762732	1	34	8	S109 aqnd S140 phosphorylation may affect ABCF1-eIF2 binding  to 60S 80S subunits and small polysomes.  	
FAK	EC 2.7.1.112; EC 2.7.10.2; KINASE; Kinase, protein; Protein kinase, TK; Protein kinase, tyrosine (non-receptor)	Q05397	5747	PTK2	8q24.3	human	S910	PHOSPHORYLATION	447964	KLQPQEIsPPPTANL			cytoskeletal reorganization; cell adhesion, altered; cell growth, altered			3394319	16	26	0		
RCHY1	EC 6.3.2.-; EC 6.3.2.19; Nuclear receptor co-regulator; UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase	Q96PM5	25898	RCHY1	4q21.1	human	T154	PHOSPHORYLATION	483981	ICLEDIHtSRVVAHV	zf-RING_2	ubiquitination; intracellular localization; enzymatic activity, inhibited	cell growth, altered	p53(DISRUPTS)		12004	1	1	0	cytoplasmic localization	
TBC1D1	GTPase activating protein, Rab; Ubiquitin-specific protease	Q60949	57915	Tbc1d1		mouse	S501	PHOSPHORYLATION	3996102	AKRSLTEsLESILSR		activity, inhibited				25779409	1	5	2	reduces inhibitory effect on TBC1D1 on GLUT4 translocation	
AurA	EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor)	Q91820	397925	aurka		frog	T295	PHOSPHORYLATION	448784	APSSRRTtLCGTLDY	Pkinase	enzymatic activity, induced				7276	26	4	7		
POLM	DNA repair; EC 2.7.7.7; Transferase	Q9NP87	27434	POLM	7p13	human	S372	PHOSPHORYLATION	28758702	HQHSCCEsPTRLAQQ		molecular association, regulation; enzymatic activity, inhibited			DNA(DISRUPTS)	28723104	1	0	0		
PR	DNA binding protein; Nuclear receptor	P06401	5241	PGR	11q22-q23	human	S676	PHOSPHORYLATION	450154	LSQRFTFsPGQDIQL			transcription, induced			7324125	3	1	0		
SRF	Motility/polarity/chemotaxis; Transcription factor	P11831	6722	SRF	6p21.1	human	S251	PHOSPHORYLATION	13203802	TDLTYQVsESDSSGE			transcription, inhibited			12660602	1	0	0		
NPM-ALK	Kinase, protein; Protein kinase, TK; Protein kinase, tyrosine (receptor)	AAA58698		NPM/ALK		human	S497	PHOSPHORYLATION	27275105	AKREEERsPAAPPPL		phosphorylation	carcinogenesis, altered; cell growth, altered			17482910	1	1	0		
Hic-5	Motility/polarity/chemotaxis; Nuclear receptor co-regulator; Transcription, coactivator/corepressor	O43294	7041	TGFB1I1	16p11.2	human	Y60	PHOSPHORYLATION	450964	SGDKDHLySTVCKPR	Paxillin	molecular association, regulation; activity, inhibited	transcription, altered	SH2D1B(NOT_REPORTED); CSK(INDUCES); AR(DISRUPTS)		3483; 3213; 27932900	3	3	20		
MARK2	EC 2.7.11.1; EC 2.7.11.26; KINASE; Kinase, protein; Protein kinase, CAMK; Protein kinase, Ser/Thr (non-receptor)	CAB06295	60328	Mark2		rat	T539	PHOSPHORYLATION	453427	RGVSSRStFHAGQLR		enzymatic activity, inhibited				2865419	4	3	1		
PXN	Adaptor/scaffold; Cell adhesion; Cytoskeletal protein; Motility/polarity/chemotaxis	Q8VI36	19303	Pxn		mouse	S126	PHOSPHORYLATION	450227	SFPNKQKsAEPSPTV	Paxillin		cell motility, altered; cytoskeletal reorganization			7852	6	14	4	regulates cells spreading	
SRF	Motility/polarity/chemotaxis; Transcription factor	P11831	6722	SRF	6p21.1	human	S85	PHOSPHORYLATION	451801	GSEGDSEsGEEEELG		molecular association, regulation			DNA(INDUCES)	1646	3	4	0		
GH receptor	Membrane protein, integral; Receptor, cytokine	P16310	25235	Ghr		rat	Y487	PHOSPHORYLATION	450479	SLANIDFyAQVSDIT	GHBP	molecular association, regulation		SHP-2(INDUCES)		3110	2	0	0	Minor SHP-2 interacting phosphorylation site. 
	
HSF1	DNA binding protein; Transcription factor	P38532	15499	Hsf1		mouse	S307	PHOSPHORYLATION	449046	EPPSPPHsPRVLEAS	Vert_HS_TF	activity, inhibited	transcription, altered			6288	11	24	3		
Bid	Apoptosis; Mitochondrial	P70444	12122	Bid		mouse	S78	PHOSPHORYLATION	456957	RIEPDSEsQEEIIHN	BID		cell cycle regulation; apoptosis, inhibited			6760; 6761	3	2	0		
HER2	EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Protein kinase, TK; Protein kinase, tyrosine (receptor)	P06494	24337	Erbb2		rat	Y1250	PHOSPHORYLATION	447614	PTAENPEyLGLDVPV		molecular association, regulation	cell growth, altered	EGFR(INDUCES); Chk1(INDUCES)		4723; 7048; 2852602	41	7	174		
Yes	EC 2.7.10.2; KINASE; Kinase, protein; Protein kinase, TK; Protein kinase, tyrosine (non-receptor)	P07947	7525	YES1	18p11.31-p11.21	human	Y537	PHOSPHORYLATION	447620	FTATEPQyQPGENL_		enzymatic activity, inhibited				2078	4	12	1247	Yes activates Fer and Fyn kinases.	
NFkB-p65	DNA binding protein; Nuclear receptor co-regulator; Transcription factor	Q04206	5970	RELA	11q13	human	S529	PHOSPHORYLATION	447799	GLPNGLLsGDEDFSS		activity, induced; intracellular localization	transcription, induced; transcription, altered			1194; 6014; 4966805	12	1	1		
MTSS1	Adaptor/scaffold; Motility/polarity/chemotaxis	Q8R1S4	211401	Mtss1		mouse	Y397	PHOSPHORYLATION	463827	HLPDYAHyYTIGPGM			cytoskeletal reorganization			9305	1	0	6		
Myb	DNA binding protein; Transcription factor	P06876	17863	Myb		mouse	S556	PHOSPHORYLATION	1308923	TQLFSQAsPVADAPN	Cmyb_C	protein degradation				1172847	1	0	0	stress-induced degredation	
DAB1 iso2	Adaptor/scaffold	Q6XBN7		Dab1		chicken	S475	PHOSPHORYLATION	479422	TPAPRQSsPSKSSAS		protein degradation; ubiquitination				17482928	7	0	0		
EGLN2	EC 1.14.11.-; EC 1.14.11.29; Oxidoreductase	Q96KS0	112398	EGLN2	19q13.2	human	S132	PHOSPHORYLATION	4213804	GGDAPSPsKRPWARQ		enzymatic activity, inhibited				4049505	1	0	0		
STRAP	Adaptor/scaffold; RNA splicing	Q9Y3F4	11171	STRAP	12p12.3	human	T175	PHOSPHORYLATION	11267002	LWDHATMtEVKSLNF		phosphorylation	apoptosis, altered			11189926	2	1	0	negatively regulates ASK1 phosphorylation and ASK1-mediated signaling 	
CACNG2	Channel, calcium; Membrane protein, integral; Membrane protein, multi-pass	O88602	12300	Cacng2		mouse	S241	PHOSPHORYLATION	455317	QRRSRSSsRSTEPSH	Tetraspannin	activity, induced; intracellular localization				22913905; 4485	1	0	0	AMPAR immobilization in synaptic membrane; enhances AMPA receptor responses and is required for long-term potentiation	
KIF17	Microtubule binding protein; Motor protein	Q99PW8	16559	Kif17		mouse	S1029	PHOSPHORYLATION	1720900	SKAKRKKsKNSFGGE		molecular association, regulation		APBA1(DISRUPTS)		1713120	1	0	0		
ITGB4 iso2	Cell adhesion; Membrane protein, integral; Motility/polarity/chemotaxis; Receptor, misc.	P16144-2	3691	ITGB4	17q25	human	Y1642	PHOSPHORYLATION	450143	GLSENVPyKFKVQAR	fn3	molecular association, regulation	cell adhesion, altered	Shc1(INDUCES)		2765	1	0	0		
RhoE	G protein; G protein, monomeric, Rho; Motility/polarity/chemotaxis	P61587	390	RND3	2q23.3	human	S11	PHOSPHORYLATION	455489	RRASQKLsSKSIMDP		protein stabilization; intracellular localization				5218	1	0	0		
Huntingtin	Cytoskeletal protein	P42858	3064	HTT	4p16.3	human	S534	PHOSPHORYLATION	465626	EDILSHSsSQVSAVP		protein stabilization				8084	0	1	0	reduces cellular toxicity	
ESYT1	Membrane protein, integral; Membrane protein, multi-pass	Q3U7R1	23943	Esyt1		mouse	S314	PHOSPHORYLATION	15409842	QDVAQLRsPLPRGII		molecular association, regulation		GLUT4(INDUCES)		26404900	1	0	3	activates insulin-dependent glucose uptake	
KLC2	Microtubule binding protein; Motor protein	Q9H0B6	64837	KLC2	11q13.2	human	S582	PHOSPHORYLATION	452949	PRMKRASsLNFLNKS		molecular association, regulation		14-3-3 beta(INDUCES)		21683737	2	36	61	mutation of this site prevents 14-3-3 binding (pan-14-3-3 antibody)	
WSTF	DNA replication; EC 2.7.10.2; KINASE; Kinase, protein; Nuclear receptor co-regulator; Protein kinase, Ser/Thr (non-receptor)	Q9UIG0	9031	BAZ1B	7q11.23	human	S158	PHOSPHORYLATION	3215310	KSDGACDsPSSDKEN		molecular association, regulation				10353932	1	6	5	required for formation of the ATP-dependent chromatin remodeling complex WINAC (WSTF Including Nucleosome Assembly Complex) 	
CSF2RB	Membrane protein, integral; Receptor, cytokine	P32927	1439	CSF2RB	22q13.1	human	Y766	PHOSPHORYLATION	450104	VKSGFEGyVELPPIE		activity, induced; molecular association, regulation	apoptosis, altered; transcription, altered; cell growth, altered	Lyn(INDUCES); Shc1(INDUCES); Grb2(INDUCES)		2707; 3329; 2722; 8533; 3210	6	1	9		
eIF2B-epsilon	Translation; Translation initiation	Q64350	192234	Eif2b5		rat	S712	PHOSPHORYLATION	449907	LREAEEEsSDDD___	W2	molecular association, regulation		eIF2-alpha(INDUCES)		1618	3	4	2		
SHP-1	EC 3.1.3.48; Motility/polarity/chemotaxis; PHOSPHATASE; Protein phosphatase, tyrosine (non-receptor)	P29351	15170	Ptpn6		mouse	Y564	PHOSPHORYLATION	448912	SKHKEEVyENVHSKS		enzymatic activity, induced	cell growth, altered			17613012	5	8	740		
TAO1	EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, STE; Protein kinase, Ser/Thr (non-receptor)	Q7L7X3	57551	TAOK1	17q11.2	human	S990	PHOSPHORYLATION	3627517	SRSTSVTsQISNGSH		activity, induced	cell cycle regulation			12287	1	0	4		
Mnk1	EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, CAMK; Protein kinase, Ser/Thr (non-receptor); Translation	Q9BUB5	8569	MKNK1	1p33	human	T250	PHOSPHORYLATION	447621	NSCTPITtPELTTPC	Pkinase	enzymatic activity, induced	apoptosis, inhibited; cell growth, altered			2717400; 762706; 4313600	11	0	1	Disruption of Mnk1 Mnk2 enhances As2O4 inducedapoptosis.	
Kit	EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Protein kinase, TK; Protein kinase, tyrosine (receptor)	P10721	3815	KIT	4q11-q12	human	Y568	PHOSPHORYLATION	448014	EEINGNNyVYIDPTQ		activity, induced; protein degradation; molecular association, regulation; receptor internalization, altered; enzymatic activity, induced; phosphorylation	cell growth, altered	Cbl(INDUCES); CTK(INDUCES); Src(INDUCES); APS(INDUCES); SHP-2(INDUCES)		13852012; 5409; 1032; 22518522; 8979; 10274611; 2599	11	2	18		
desmin	Cytoskeletal protein; Motility/polarity/chemotaxis	P17661	1674	DES	2q35	human	S60	PHOSPHORYLATION	449614	VYQVSRTsGGAGGLG	Filament_head	intracellular localization	cytoskeletal reorganization			2253	2	4	0	Mutated desmin sites showed failure of desmin filaments to segregate into daughter cells. ; Phosphorylated at the clevage furrow during cytokinesis. 	
ANXA1	Calcium-binding protein; Lipid binding protein	P04083	301	ANXA1	9q21.13	human	S45	PHOSPHORYLATION	9730700	PYPTFNPsSDVAALH		intracellular localization	exocytosis, altered			9689603	1	0	0	S27A or S45A mutations prevented translocation of ANXA1 to the plasma membrane and stimulated ACTH release	
Snail2	Apoptosis; C2H2-type zinc finger protein; Motility/polarity/chemotaxis; Transcription factor	O43623	6591	SNAI2	8q11	human	S96	PHOSPHORYLATION	25603908	PPPSDTSsKDHSGSE	Rpr2	protein degradation; intracellular localization	transcription, induced			25582516	1	0	0	 WT localizes in cytosol and nucleus; transcriptional activity of E-cadherin;  WT localized in nucleus and cytoplasm, mutants localize in nucleus;  mutants enhance epithelial-mesenchymal transition (EMT)	
P130Cas	Adaptor/scaffold; Motility/polarity/chemotaxis	P56945	9564	BCAR1	16q23.1	human	Y165	PHOSPHORYLATION	448722	PSPATDLyQVPPGPG			carcinogenesis, induced; cell motility, induced; cell adhesion, induced; cytoskeletal reorganization			25027306	7	0	0	P130Cas phosphorylation is important in development of peripheral adhesion complexes, oncogenic signaling, and cell migration. 	
CEACAM1	Cell adhesion; Immunoglobulin superfamily; Membrane protein, integral; Motility/polarity/chemotaxis	P16573	81613	Ceacam1		rat	Y488	PHOSPHORYLATION	447777	NKVDDVSySVLNFNA		activity, induced				2572; 2573	7	1	0	phosphorylation of this site may regulate the kinetics of bile acid efflux activity of CEACAM1; Phosphorylation of CEACAM1 induces Ca2+/Mg2+-dependent ecto ATPase activity. 	
ELK4	DNA binding protein; Transcription, coactivator/corepressor	P41158	13714	Elk4		mouse	S380	PHOSPHORYLATION	4317600	IHFWSTLsPFAPLSP			cell growth, altered			4317100	2	0	0	pro-B cell expansion	
IRS4	Adaptor/scaffold	O14654	8471	IRS4	Xq22.3	human	Y921	PHOSPHORYLATION	456294	EADSSSDyVNMDFTK		molecular association, regulation		PLCG1(INDUCES); PIK3R1(INDUCES); Grb2(INDUCES)		6729	0	3	15		
InsR iso2	EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Protein kinase, TK; Protein kinase, tyrosine (receptor)	P06213-2	3643	INSR	19p13.3-p13.2	human	Y1343	PHOSPHORYLATION	447683	SLGFKRSyEEHIPYT		activity, inhibited	cell cycle regulation			2652	14	4	2		
p47phox	EC 1.-.-.-; Oxidoreductase	P14598	653361	NCF1	7q11.23	human	S320	PHOSPHORYLATION	451726	QRSRKRLsQDAYRRN		molecular association, regulation		CYBA(INDUCES)		8704	8	5	8		
ACTN4	Cytoskeletal protein; Motility/polarity/chemotaxis	O43707	81	ACTN4	19q13	human	Y31	PHOSPHORYLATION	11498502	GGGSMGDyMAQEDDW		molecular association, regulation	cytoskeletal reorganization; cell growth, altered	ACTA1(DISRUPTS)		11419364	1	1	0	F-actin binding	
GluR4	Channel, ligand-gated; Membrane protein, integral; Membrane protein, multi-pass	P19493	29629	Gria4		rat	S862	PHOSPHORYLATION	448810	TRNKARLsITGSVGE		receptor internalization, altered; intracellular localization				1988	5	5	1		
GluR-delta2	Channel, calcium; Channel, ligand-gated; Membrane protein, integral; Membrane protein, multi-pass	Q63226	79220	Grid2		rat	S945	PHOSPHORYLATION	3595502	QTLSRTLsAKAASGF		molecular association, regulation		AIP1(INDUCES)		3660903	3	0	0		
PGC-1 alpha	Nuclear receptor co-regulator; Transcription, coactivator/corepressor	Q9UBK2	10891	PPARGC1A	4p15.1	human	S571	PHOSPHORYLATION	2045307	RMRSRSRsFSRHRSC		activity, inhibited				13358800	3	0	0		
CDK7	EC 2.7.11.22; EC 2.7.11.23; KINASE; Kinase, protein; Nuclear receptor co-regulator; Protein kinase, CMGC; Protein kinase, Ser/Thr (non-receptor)	P50613	1022	CDK7	5q12.1	human	T170	PHOSPHORYLATION	448306	GSPNRAYtHQVVTRW	Pkinase	enzymatic activity, induced	transcription, altered			13245301	4	37	85		
SLC6A4	Membrane protein, integral; Membrane protein, multi-pass; Transporter	P31645	6532	SLC6A4	17q11.2	human	T616	PHOSPHORYLATION	7576402	IKSITPEtPTEIPCG		molecular association, regulation; intracellular localization		vimentin(DISRUPTS)		7543512	1	0	0		
MARK2 iso13	EC 2.7.11.1; EC 2.7.11.26; KINASE; Kinase, protein; Protein kinase, CAMK; Protein kinase, Ser/Thr (non-receptor)	A9CP04	2011	MARK2	11q13.1	human	T324	PHOSPHORYLATION	4145507	RYNEVMAtYLLLGYK	UBA	intracellular localization	cytoskeletal reorganization; cell growth, altered			4049516	1	0	0		
eNOS	Amino Acid Metabolism - arginine and proline; EC 1.14.13.39; Oxidoreductase	P29473	287024	NOS3		cow	S116	PHOSPHORYLATION	448638	RKLQTRPsPGPPPAE		molecular association, regulation; enzymatic activity, inhibited; phosphorylation		Akt1(DISRUPTS)		5899; 5695	17	2	0		
UBC3B	EC 6.3.2.19; Ligase; UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase	Q712K3	54926	UBE2R2	9p13.3	human	S233	PHOSPHORYLATION	449751	DCYDDDDsGNEES__		molecular association, regulation	transcription, altered	BRD8 iso1(INDUCES)		1848	1	2	0	CK2-dependent phosphorylation of UCB3C leads to beta-catenin degredation and  inhibition of beta-catenin transcription.	
MYBPC3	Myosin binding protein	Q14896	4607	MYBPC3	11p11.2	human	S304	PHOSPHORYLATION	471081	SLLKKSSsFRTPRDS			cytoskeletal reorganization			12662610	15	3	0	regulation of cardiac myofilament function	
HSF1	DNA binding protein; Transcription factor	P38532	15499	Hsf1		mouse	S303	PHOSPHORYLATION	449045	RVKQEPPsPPHSPRV	Vert_HS_TF	activity, inhibited	transcription, altered			6288	11	26	5		
ATM	EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, ATYPICAL; Protein kinase, Ser/Thr (non-receptor)	Q13315	472	ATM	11q22-q23	human	S1403	PHOSPHORYLATION	22496700	CHKTKLKsILEILSK		enzymatic activity, induced	cell cycle regulation			22463922	1	0	0	phosphorylation of S1403 is required for mitotic activation of ATM; required for the spindle checkpoint activation	
smMLCK	EC 2.7.11.18; KINASE; Kinase, protein; Protein kinase, CAMK; Protein kinase, Ser/Thr (non-receptor)	P29294	100009143	MYLK		rabbit	S1011	PHOSPHORYLATION	468782	SSTGSPTsPLTAERL	DUF2656	intracellular localization				8842	5	12	2		
TAB1	Activator protein; Motility/polarity/chemotaxis	Q15750	10454	TAB1	22q13.1	human	T431	PHOSPHORYLATION	456223	ASTLDEAtPTLTNQS		activity, inhibited; phosphorylation				7549215; 4328	5	0	1	inhibits phosphorylation of TAK1; inhibits TAK1 T187 phosphorylation	
CFTR	Channel, chloride; EC 3.6.3.49; Hydrolase; Membrane protein, integral; Membrane protein, multi-pass; Transporter	P13569	1080	CFTR	7q31.2	human	S511	PHOSPHORYLATION	477193	ENIIFGVsYDEYRYR	ABC_tran	activity, induced				9369	2	0	0	regulates CFTR channel gating	
G3BP-1	Adaptor/scaffold; EC 3.6.1.-; EC 3.6.4.12; EC 3.6.4.13; Helicase	Q13283	10146	G3BP1	5q33.1	human	S232	PHOSPHORYLATION	449042	EDAQKSSsPAPADIA		molecular association, regulation; protein conformation		G3BP-1(DISRUPTS)		2073	3	61	25		
LATS2	EC 2.7.11.1; KINASE; Kinase, protein; Nuclear receptor co-regulator; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor)	Q9NRM7	26524	LATS2	13q11-q12	human	S408	PHOSPHORYLATION	17600400	PVPSRTNsFNSHQPR			cell cycle regulation; apoptosis, inhibited			17431548	1	1	0		
Rb	Nuclear receptor co-regulator; Transcription, coactivator/corepressor; Tumor suppressor	P06400	5925	RB1	13q14.2	human	T356	PHOSPHORYLATION	447981	DSFETQRtPRKSNLD		molecular association, regulation		E2F1(DISRUPTS)		14146309	6	8	28		
MAPKAPK2	EC 2.7.1.-; EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, CAMK; Protein kinase, Ser/Thr (non-receptor)	P49137	9261	MAPKAPK2	1q32	human	S272	PHOSPHORYLATION	448268	SNHGLAIsPGMKTRI	Pkinase	activity, induced				812	1	0	0		
IRS1	Adaptor/scaffold; Motility/polarity/chemotaxis	P35568	3667	IRS1	2q36	human	Y896	PHOSPHORYLATION	447556	EPKSPGEyVNIEFGS		molecular association, regulation; phosphorylation	cell cycle regulation	Grb2(INDUCES)		1141	8	1	0	Erk1/2 phosphorylation	
FANCD2	DNA repair	Q9BXW9	2177	FANCD2	3p26	human	T691	PHOSPHORYLATION	470035	YGLEEYDtQDGIAIN		activity, induced	cell cycle regulation			8943	1	1	2	promotes monoubiquitination of FANCD2	
AR	DNA binding protein; Nuclear receptor; Transcription factor	P10275	367	AR	Xq12	human	S94	PHOSPHORYLATION	448416	QQQGEDGsPQAHRRG	Androgen_recep		transcription, altered			8049	7	5	0		
CSFR	EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Protein kinase, TK; Protein kinase, tyrosine (receptor)	P07333	1436	CSF1R	5q32	human	Y809	PHOSPHORYLATION	448365	DIMNDSNyIVKGNAR	Pkinase_Tyr	activity, induced; phosphorylation	cell cycle regulation; transcription, altered; cell growth, altered			2180; 4624; 1046; 4894704	21	2	12		
SNX18	Motility/polarity/chemotaxis; Vesicle protein	Q96RF0	112574	SNX18	5q11.2	human	S233	PHOSPHORYLATION	7322488	SRNLNRFsTFVKSGG			autophagy, inhibited			28119011	1	1	0		
SULT4A1	EC 2.8.2.-; Transferase	Q9BR01	25830	SULT4A1	22q13.2	human	T11	PHOSPHORYLATION	2048305	SEAETPStPGEFESK		protein degradation; molecular association, regulation		Pin1(INDUCES)		16824201; 9980405	2	3	0		
PJA2	EC 6.3.2.-; EC 6.3.2.19; Ligase; UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase	O43164	9867	PJA2	5q21.3	human	T389	PHOSPHORYLATION	18713701	RVITQREtENNQMTS		ubiquitination; enzymatic activity, induced	signaling pathway regulation			18668233	1	0	0	S342A/T389A mutant fails to ubiquitylate PKAR2A in vitro	
GLI1	C2H2-type zinc finger protein; Transcription factor	P08151	2735	GLI1	12q13.2-q13.3	human	S243	PHOSPHORYLATION	27708601	DCRWDGCsQEFDSQE	IL17		cell growth, induced; transcription, induced		DNA(INDUCES)	27619353	1	0	0		
PAG	Adaptor/scaffold; Membrane protein, integral	Q9JM80	64019	Pag1		rat	Y165	PHOSPHORYLATION	454745	GPGVEGPyEVLKDSS			cell growth, altered			4338204	1	16	127		
STMN1	Cytoskeletal protein	P16949	3925	STMN1	1p36.11	human	S63	PHOSPHORYLATION	448557	AAEERRKsHEAEVLK	Stathmin; CDC37_N	molecular association, regulation; activity, inhibited	cell cycle regulation; apoptosis, altered; cytoskeletal reorganization	TUBA4A(DISRUPTS); TUBA1A(DISRUPTS); TUBB(DISRUPTS)		8941; 7742; 2797; 7802; 1288; 7543504; 8835; 2798	13	23	25	in vitro; constitutive phosphorylation leads to G2/M arrest in cells from APL (acute promyelocytic leukemia) patients that express a PML-RAR alpha fusion protein.	
G6PD	Carbohydrate Metabolism - pentose phosphate pathway; Cell development/differentiation; EC 1.1.1.49; Other Amino Acids Metabolism - glutathione; Oxidoreductase	P11413	2539	G6PD	Xq28	human	Y428	PHOSPHORYLATION	7705803	DLTYGNRyKNVKLPD	G6PD_C		cell motility, altered			7549208	1	0	0	modulates Akt activity	
CYLD	EC 3.1.2.15; EC 3.4.19.12; Protease; Ubiquitin conjugating system; Ubiquitin-specific protease	Q9NQC7	1540	CYLD	16q12.1	human	S436	PHOSPHORYLATION	12173907	TNGSIGHsPLSLSAQ		ubiquitination				12156302	1	0	0	induces ubiquitination of TRAF2	
LAT iso2	Adaptor/scaffold; Membrane protein, integral	O43561-2	27040	LAT	16p11.2	human	Y171	PHOSPHORYLATION	448004	SMESIDDyVNVPESG	LAT	activity, induced; molecular association, regulation; phosphorylation	cell differentiation, altered; cell adhesion, altered; transcription, altered	PLCG1(INDUCES); GADS(INDUCES); Grb2(INDUCES)		3767; 2891; 3632; 1909	13	0	17		
Shc1 iso2	Adaptor/scaffold; Apoptosis; Mitochondrial; Motility/polarity/chemotaxis	P98083-2	20416	Shc1		mouse	Y239	PHOSPHORYLATION	448509	EEPPDHQyYNDFPGK		activity, induced; molecular association, regulation; phosphorylation	cell motility, induced; cell motility, altered	Grb2(INDUCES)		27519622; 2195488	27	15	922	angiogenesis;  required for ErbB2- and TGFB mediated tumor metastasis to the lungs.; metastatic spread of tumors; required for migration and invasion of ERB2-expressing cells	
ER-beta	DNA binding protein; Nuclear receptor	O08537	13983	Esr2		mouse	S87	PHOSPHORYLATION	447915	WPTSGHLsPLATHCQ	ERbeta_N; Oest_recep	molecular association, regulation		SRC-1(INDUCES)		1025500	3	0	0	Transcription is not ligand (estrogen) dependent through this mechanism.	
ELF4	DNA binding protein; Transcription factor	Q99607	2000	ELF4	Xq26	human	S648	PHOSPHORYLATION	463814	SPTPAPFsPFNPTSL		protein degradation				7869	1	4	1	phosphorylation of this site is required for ELF4 ubiquitination	
PLK1	EC 2.7.11.21; KINASE; Kinase, protein; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor)	P53350	5347	PLK1	16p12.2	human	S49	PHOSPHORYLATION	2715404	EVLVDPRsRRRYVRG		enzymatic activity, induced	cell cycle regulation			2704329	1	0	0		
IP3R1	Channel, calcium; Channel, ligand-gated; Membrane protein, integral; Membrane protein, multi-pass; Receptor, misc.	P29994	25262	Itpr1		rat	S1589	PHOSPHORYLATION	450681	RNAARRDsVLAASRD		activity, induced; receptor inactivation, altered				5445; 4269	8	26	2	Mutation of site to Glu enhanced, while mutation to Ala inhibited, calcium release through IP3R1.; increases the open probability of the IP3R receptor Ca(2+) channel	
SHEP1	Adaptor/scaffold	Q9QZS8	27387	Sh2d3c		mouse	Y787	PHOSPHORYLATION	452180	VAHHGGLyHTNAEVK		molecular association, regulation	cytoskeletal reorganization	P130Cas(DISRUPTS)		4096	1	1	1	Y787 phosphorylation inhibits cell migration and membrane ruffling	
Ack	EC 2.7.10.2; EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, TK; Protein kinase, tyrosine (non-receptor)	Q07912	10188	TNK2	3q29	human	Y284	PHOSPHORYLATION	450946	LPQNDDHyVMQEHRK	Pkinase_Tyr	enzymatic activity, induced				7433	5	15	203	in vitro assay of enzyme activity	
IRS1	Adaptor/scaffold; Motility/polarity/chemotaxis	P35569	16367	Irs1		mouse	S302	PHOSPHORYLATION	450190	TRRSRTEsITATSPA		phosphorylation	cell growth, altered			2852	31	3	1	leads to increased tyrosine phosphorylation of IRS-1 and increased phosphorylation of p70S6K, S6, and 4E-BP1.	
MAP9	Cell cycle regulation	Q49MG5	79884	MAP9	4q32.1	human	S625	PHOSPHORYLATION	999603	RKQKKRHsFLESEAL	DUF4207		cytoskeletal reorganization			970034	2	1	2	correct spindle formation during mitosis	
H3	DNA binding protein	P68433	360198	Hist1h3a		mouse	K10	TRI-METHYLATION	1458613	RTKQTARkSTGGKAP		molecular association, regulation; intracellular localization		HP1 alpha(INDUCES)		17482902; 18021019	86	3	1		
MRLC2	Contractile protein	Q3THE2	67938	Myl12b		mouse	S2	PHOSPHORYLATION	448593	______MsSKKAKTK			cytoskeletal reorganization; cell adhesion, altered			970037	1	0	0	induced disassembly of stress fibers and decreased large focal adhesions	
ERK1	EC 2.7.1.123; EC 2.7.11.24; KINASE; Kinase, protein; Protein kinase, CMGC; Protein kinase, Ser/Thr (non-receptor)	Q63844	26417	Mapk3		mouse	T203	PHOSPHORYLATION	447542	HDHTGFLtEYVATRW	Pkinase; YukC	enzymatic activity, induced	transcription, altered			5766; 5209; 5354414; 6947; 898; 5691; 4862602	994	51	1957		
NFAT5	Transcription factor	Q9WV30	54446	Nfat5		mouse	Y143	PHOSPHORYLATION	12127405	PKRHTVLyISPPPED		molecular association, regulation	transcription, inhibited	TAZ(INDUCES)		27132466	4	1	0	 Y316 TAZ negatively regulates SL6A12 and SLC5A3 gene expression; luciferase reporter	
Smc1	DNA replication; RNA splicing	Q14683	8243	SMC1A	Xp11.22-p11.21	human	S957	PHOSPHORYLATION	448697	ISQEEGSsQGEDSVS	SMC_N	molecular association, regulation; intracellular localization	cell cycle regulation; cytoskeletal reorganization	RAE1(INDUCES)		3186; 6271034; 1871	16	11	50		
GCH1	Cofactor and Vitamin Metabolism - folate biosynthesis; EC 3.5.4.16; Hydrolase	P22288	29244	Gch1		rat	T85	PHOSPHORYLATION	10428812	QRQGLLKtPWRAATA		enzymatic activity, induced				10353908	1	0	0		
SRC-3	ACETYLTRANSFERASE; Acetyltransferase; EC 2.3.1.48; Motility/polarity/chemotaxis; Nuclear receptor co-regulator; Transcription, coactivator/corepressor	Q9Y6Q9	8202	NCOA3	20q12	human	S860	PHOSPHORYLATION	454106	NRAVSLDsPVSVGSS		molecular association, regulation		ER-alpha(DISRUPTS)		4214	5	9	0	Mutations to alanine inhibited protein-protein interactions. 	
eEF-2	Translation; Translation elongation	P55823		EEF2		rabbit	T56	PHOSPHORYLATION	448040	RAGETRFtDTRKDEQ	GTP_EFTU	activity, inhibited				2334	24	25	48		
SF1	RNA binding protein; RNA splicing; Spliceosome; Transcription, coactivator/corepressor	NP_001104263	117855	Sf1		rat	S20	PHOSPHORYLATION	449919	PSKKRKRsRWNQDTM		molecular association, regulation	RNA splicing, altered	U2AF2(DISRUPTS)		12482236	2	1	0		
SLC6A2	Membrane protein, integral; Membrane protein, multi-pass; Transporter	P23975	6530	SLC6A2	16q12.2	human	S259	PHOSPHORYLATION	465614	LWKGVKTsGKVVWIT	SNF	intracellular localization; activity, inhibited				8095	2	0	0	effect observed in T258, S259 double mutant	
NMDAR1	Channel, calcium; Channel, ligand-gated; Membrane protein, integral; Membrane protein, multi-pass	P35439	24408	Grin1		rat	S897	PHOSPHORYLATION	448256	SFKRRRSsKDTSTGG		molecular association, regulation		calmodulin(DISRUPTS)		1706	24	0	0		
NKCC2	Membrane protein, integral; Membrane protein, multi-pass; Transporter	P55015	100328575	SLC12A1		rabbit	T104	PHOSPHORYLATION	458228	LQTFGHNtMDAVPKI	AA_permease_N	activity, induced				6707	7	2	0		
ULK1	Autophagy; EC 2.7.1.37; EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor)	O70405	22241	Ulk1		mouse	S467	PHOSPHORYLATION	483136	SAIRRSGsTTPLGFG			autophagy, altered			17740400	3	12	5		
Kv2.1	Channel, cation; Channel, ligand-gated; Channel, potassium; Membrane protein, integral; Membrane protein, multi-pass	P15387	25736	Kcnb1		rat	S484	PHOSPHORYLATION	473560	KVQDNHLsPNKWKWT	Kv2channel	activity, inhibited				9216	1	5	7		
MLK3	EC 2.7.11.25; KINASE; Kinase, protein; Protein kinase, Ser/Thr (non-receptor); Protein kinase, TKL	Q16584	4296	MAP3K11	11q13.1-q13.3	human	T277	PHOSPHORYLATION	448263	LAREWHKtTQMSAAG	Pkinase_Tyr	molecular association, regulation; enzymatic activity, induced		GEFT(INDUCES)		717; 7124734	6	0	0	p-MLK3 regulates levels of activated GEFT	
TCF7L2	Apoptosis; Cell cycle regulation; Cell development/differentiation; DNA binding protein; Motility/polarity/chemotaxis; Transcription factor	Q9NQB0	6934	TCF7L2	10q25.3	human	S177	PHOSPHORYLATION	14918200	QALKDARsPSPAHIV	CTNNB1_binding		transcription, induced			14784605	1	1	0		
KCNJ12	Membrane protein, integral; Membrane protein, multi-pass	P52188	117052	Kcnj12		rat	S425	PHOSPHORYLATION	2150913	ERPYRREsEI_____		molecular association, regulation		DLG1(DISRUPTS)		10292911	1	0	0		
Lck	EC 2.7.10.2; KINASE; Kinase, protein; Protein kinase, TK; Protein kinase, tyrosine (non-receptor)	P06240	16818	Lck		mouse	Y505	PHOSPHORYLATION	447823	FTATEGQyQPQP___		protein stabilization; intracellular localization; enzymatic activity, inhibited	cell cycle regulation; apoptosis, altered			3305; 1163206; 4061; 7991114; 5299	35	22	796		
HER3	EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Protein kinase, TK; Protein kinase, tyrosine (receptor)	P21860	2065	ERBB3	12q13	human	Y1289	PHOSPHORYLATION	449858	CPASEQGyEEMRAFQ			carcinogenesis, induced; cell growth, altered			14148603	13	4	116		
SF2	RNA binding protein; RNA splicing; Spliceosome	NP_001103022	689890	Sfrs1		rat	S234	PHOSPHORYLATION	468704	SPRRSRGsPRYSPRH	Corona_nucleoca; DUF1509; DUF1777	intracellular localization				5007900	2	22	15	inhibits tau exon 10 inclusion, and increases 3R-tau production 	
MDM4	EC 6.3.2.-; Ligase; UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase	O35618	17248	Mdm4		mouse	S341	PHOSPHORYLATION	470031	SKLTHSLsTSNITAI	Cript	molecular association, regulation	signaling pathway regulation	14-3-3 gamma(INDUCES)		25347018	11	2	3	important for p53 activation 	
IGF1R	EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Protein kinase, TK; Protein kinase, tyrosine (receptor)	P08069	3480	IGF1R	15q26.3	human	Y1161	PHOSPHORYLATION	448386	FGMTRDIyETDYYRK	Pkinase_Tyr	molecular association, regulation; receptor internalization, altered; protein conformation; enzymatic activity, induced		Src(INDUCES)		2407108; 7397608; 2852613; 6783	16	19	453	in vitro	
CTNNB1	Actin binding protein; Cell adhesion; Motility/polarity/chemotaxis; Nuclear receptor co-regulator; Transcription factor	Q02248	12387	Ctnnb1		mouse	S552	PHOSPHORYLATION	472273	QDTQRRTsMGGTQQQ		intracellular localization	transcription, altered			14148608; 9144	10	30	9		
Notch 1	Membrane protein, integral; Motility/polarity/chemotaxis; Receptor, misc.; Transcription factor	P46531	4851	NOTCH1	9q34.3	human	S2521	PHOSPHORYLATION	467287	PESPDQWsSSSPHSN	DUF3454	protein degradation; receptor inactivation, altered				8231	1	0	0	Alanine mutation of 4 serines (S2522/S2523/S2524/S2525) causes increased protein stability.	
IRSp53	Actin binding protein; Motility/polarity/chemotaxis	Q9UQB8	10458	BAIAP2	17q25	human	T340	PHOSPHORYLATION	2049593	LSDSYSNtLPVRKSV		molecular association, regulation	cytoskeletal reorganization	14-3-3 zeta(INDUCES)		11419368	1	9	25		
Rb	Nuclear receptor co-regulator; Transcription, coactivator/corepressor; Tumor suppressor	P13405	19645	Rb1		mouse	S804	PHOSPHORYLATION	448717	IYISPLKsPYKISEG	Rb_C	molecular association, regulation; protein conformation	cell cycle regulation; cell growth, altered	E2F1(DISRUPTS)		4073; 6320800; 1258	49	20	73		
ARHGEF7 iso1	Guanine nucleotide exchange factor, Rac/Rho; Motility/polarity/chemotaxis	Q14155-1	8874	ARHGEF7	13q34	human	S525	PHOSPHORYLATION	455681	EEFASRKsTAALEED		activity, induced	cytoskeletal reorganization			7991129	3	12	2	S525/T526 phosphorylation regulates Rac1 activation and growth cone extension/retraction.	
GCM1	DNA binding protein; Transcription factor	Q9NP62	8521	GCM1	6p12.1	human	S322	PHOSPHORYLATION	7979600	NYPFPLTsWPCSFSP		protein degradation; molecular association, regulation; ubiquitination		FBXW2(INDUCES)		7889912	2	0	0		
CD3E	Membrane protein, integral; Receptor, misc.	P22646	12501	Cd3e		mouse	Y181	PHOSPHORYLATION	448917	RKGQRDLySGLNQRA	ITAM	molecular association, regulation		PIK3R1(INDUCES)		3942	4	11	413		
PPAR-alpha	DNA binding protein; Nuclear receptor	Q07869	5465	PPARA	22q13.31	human	S179	PHOSPHORYLATION	457549	RFGRMPRsEKAKLKA			transcription, altered			8755	2	0	0		
RbBP1	Adaptor/scaffold	P29374	5926	ARID4A	14q23.1	human	S1007	PHOSPHORYLATION	17743401	QHNFSVAsPLTLSQD		molecular association, regulation		Rb(DISRUPTS)		17675031	1	1	0		
NUP50	Nuclear import; Nucleoporin	Q9UKX7	10762	NUP50	22q13.31	human	S315	PHOSPHORYLATION	4957816	TQSKPVSsPFPTKPL		molecular association, regulation		KPNB1(DISRUPTS)		9980430	1	1	1		
Ret	EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Protein kinase, TK; Protein kinase, tyrosine (receptor)	P07949	5979	RET	10q11.2	human	Y1096	PHOSPHORYLATION	449891	RYPNDSVyANWMLSP		molecular association, regulation		PIK3R1(INDUCES); Grb2(INDUCES)		6278; 2444	7	1	3		
Rad51	DNA repair; Mitochondrial	Q06609	5888	RAD51	15q15.1	human	T13	PHOSPHORYLATION	23305002	QLEANADtSVEEESF		molecular association, regulation	DNA repair, induced	NBS1(INDUCES)		23260334	1	1	0	involved in DNA damage recognition and homologous recombination (HR) repair	
Rb-like 2	Transcription, coactivator/corepressor	Q08999	5934	RBL2	16q12.2	human	S662	PHOSPHORYLATION	449728	GLGRSITsPTTLYDR		molecular association, regulation	cell cycle regulation	E2F4(DISRUPTS)		1200; 5981	3	6	3		
PDE4C iso2	EC 3.1.4.17; Nucleotide Metabolism - purine; Phosphodiesterase	Q08493-2	5143	PDE4C	19p13.11	human	S535	PHOSPHORYLATION	471381	YQSKIPRsPSDLTNP		enzymatic activity, inhibited				9133	1	3	0		
BLM	DNA repair; DNA replication; EC 3.6.1.-; EC 3.6.4.12; Helicase	P54132	641	BLM	15q26.1	human	T99	PHOSPHORYLATION	450958	NAPAGQEtQRGGSKS		molecular association, regulation	cell cycle regulation; apoptosis, inhibited	H2AX(INDUCES); PML(DISRUPTS); TOP3A(DISRUPTS)		4650401; 3232; 6972	4	0	0	In cells expressing BLM T99A/T122A after HU release, entrance into G1 phase was delayed, with p-Chk-1 levels remaining  elevated. ; radiosensitivity	
Mpl	Membrane protein, integral; Receptor, cytokine	Q08351	17480	Mpl		mouse	Y616	PHOSPHORYLATION	450267	THIANHSyLPLSYWQ		activity, induced; phosphorylation	cell differentiation, altered; transcription, altered; cell growth, altered	Shc1(INDUCES)		2971; 3366; 8650; 12021327	5	1	1		
IRS1	Adaptor/scaffold; Motility/polarity/chemotaxis	P35568	3667	IRS1	2q36	human	S527	PHOSPHORYLATION	447561	RFRKRTHsAGTSPTI		intracellular localization				8915	4	8	0	via cell fractionation experiments	
Rad9	Apoptosis; Cell cycle regulation; DNA replication; Deoxyribonuclease; EC 3.1.11.2	Q99638	5883	RAD9A	11q13.1-q13.2	human	T355	PHOSPHORYLATION	449818	EPSTVPGtPPPKKFR			cell cycle regulation			13354725; 8762	3	3	11		
14-3-3 zeta	Adaptor/scaffold; Motility/polarity/chemotaxis	P63104	7534	YWHAZ	8q23.1	human	T232	PHOSPHORYLATION	449846	LTLWTSDtQGDEAEA	14-3-3	molecular association, regulation; activity, inhibited; protein conformation		14-3-3 zeta(DISRUPTS); RAF1(DISRUPTS); tau iso3(DISRUPTS); HSP20(DISRUPTS)		2394; 8207; 18415100; 4651305; 8206	4	9	20		
K8	Cytoskeletal protein	P05787	3856	KRT8	12q13	human	S74	PHOSPHORYLATION	448539	TVNQSLLsPLVLEVD	IncA	protein stabilization; molecular association, regulation; ubiquitination; intracellular localization	cell motility, altered; cytoskeletal reorganization	JNK1(INDUCES); P38A(INDUCES)		7313818; 1030; 2657; 5221; 6277007; 3459; 6352; 6115919	25	2	9		
TRPV4	Channel, cation; Membrane protein, integral; Membrane protein, multi-pass	Q9EPK8	63873	Trpv4		mouse	Y110	PHOSPHORYLATION	4777176	PMDSLFDyGTYRHHP		activity, induced; intracellular localization				6066702	2	3	0		
FGFR1	EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Protein kinase, TK; Protein kinase, tyrosine (receptor)	P11362	2260	FGFR1	8p12	human	S777	PHOSPHORYLATION	2721300	SMPLDQYsPSFPDTR		intracellular localization	cell growth, inhibited; cell motility, inhibited			27619335; 2704323	3	0	0	in DRG neurons axon length was increased in neurons overexpresing the S777A mutant. 	
P38A	EC 2.7.1.37; EC 2.7.11.24; KINASE; Kinase, protein; Protein kinase, CMGC; Protein kinase, Ser/Thr (non-receptor)	Q16539	1432	MAPK14	6p21.3-p21.2	human	T123	PHOSPHORYLATION	471074	IVKCQKLtDDHVQFL	Pkinase	molecular association, regulation; enzymatic activity, inhibited; phosphorylation	cell differentiation, altered	MAPKAPK2(DISRUPTS); MKK6(DISRUPTS)		9034	1	0	0	Phosphorylation leads to less interaction with activator (MKK6) and substrates (MAPKAPK2).	
SOX9	DNA binding protein; Transcription factor	P48436	6662	SOX9	17q23	human	S64	PHOSPHORYLATION	451039	EPDLKKEsEEDKFPV	Sox_N	molecular association, regulation; intracellular localization		KPNB1(INDUCES)		7824	5	0	0		
Casp9	Apoptosis; EC 3.4.22.62; Protease	P55211	842	CASP9	1p36.21	human	S144	PHOSPHORYLATION	458346	GDVGALEsLRGNADL		activity, inhibited	apoptosis, altered			7360	1	0	0		
AMPKA1	Autophagy; EC 2.7.1.-; EC 2.7.11.1; EC 2.7.11.26; KINASE; Kinase, protein; Protein kinase, CAMK; Protein kinase, Ser/Thr (non-receptor)	P54645	65248	Prkaa1		rat	S496	PHOSPHORYLATION	450431	ATPQRSGsISNYRSC		enzymatic activity, inhibited				4642411; 2701901; 2576204	8	25	23		
CRYAB	Chaperone	P23928	25420	Cryab		rat	S19	PHOSPHORYLATION	447728	RPFFPFHsPSRLFDQ	Crystallin		apoptosis, altered			5553	15	11	2		
TFEB	DNA binding protein	Q9R210	21425	Tfeb		mouse	S462	PHOSPHORYLATION	4785132	PEASKASsRRSSFSM		protein stabilization	transcription, induced			27928005	1	3	0		
gp130	Membrane protein, integral; Receptor, cytokine	Q00560	16195	Il6st		mouse	Y757	PHOSPHORYLATION	448181	STASTVQySTVVHSG		activity, induced; molecular association, regulation; phosphorylation	transcription, altered	SOCS3(INDUCES); SHP-2(INDUCES)		4904521; 4904522	11	1	2	protection from bacterial infection, promotes increases in IFN-gamma levels; SHP-2 phosphorylation	
HER3	EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Protein kinase, TK; Protein kinase, tyrosine (receptor)	Q62799	29496	Erbb3		rat	Y1257	PHOSPHORYLATION	449860	GTTPDEDyEYMNRRR		molecular association, regulation; phosphorylation		PIK3CB(INDUCES); PIK3R1(INDUCES)		1836	2	0	16	induces phosphorylation of Akt1.	
CENPT	DNA replication	F1NPG5		CENPT		chicken	S88	PHOSPHORYLATION	27528600	IQNQPQVsPLALQTV		molecular association, regulation		SPC25(INDUCES); SPBC24(INDUCES)		27519647	0	0	0		
eIF2B-epsilon	Translation; Translation initiation	Q64350	192234	Eif2b5		rat	S535	PHOSPHORYLATION	449905	VDPEELDsRAGSPQL			translation, altered; cytoskeletal reorganization; cell growth, altered			4861505	9	2	0	regulates cardiac hypertrophy (cell size)	
CREB	DNA binding protein; Transcription factor	P16220	1385	CREB1	2q34	human	S121	PHOSPHORYLATION	451811	SVDSVTDsQKRREIL	pKID	molecular association, regulation; activity, inhibited	transcription, inhibited	CBP(DISRUPTS)		9565; 7037	10	0	0		
Jun	Transcription factor	P05412	3725	JUN	1p32-p31	human	T91	PHOSPHORYLATION	450448	SNGHITTtPTPTQFL	Jun	molecular association, regulation	transcription, altered		DNA(DISRUPTS)	4843006; 7397639	7	0	0		
GIT1	GTPase activating protein, ARF; Motility/polarity/chemotaxis	Q68FF6	216963	Git1		mouse	S419	PHOSPHORYLATION	482779	TRNNRARsMDSSDLS		molecular association, regulation		CAMK2A(INDUCES)		27519668	1	16	6	synapsin I density is decreased in S419A mutant;  interaction is important for premature synapse formation.	
NCAM-L1	Cell adhesion; Membrane protein, integral	P32004	3897	L1CAM	Xq28	human	T1172	PHOSPHORYLATION	4702537	ARPMKDEtFGEYRSL	Bravo_FIGEY	protein degradation; protein conformation	cell motility, altered			13354728	2	4	7		
GM130	Cytoskeletal protein	Q08379	2801	GOLGA2	9q34.11	human	S37	PHOSPHORYLATION	454438	REYQQRNsPGVPTGA		molecular association, regulation		TAP(DISRUPTS)		13251003	3	9	1		
Myc	DNA binding protein; Transcription factor	P01106	4609	MYC	8q24.21	human	T58	PHOSPHORYLATION	448496	KKFELLPtPPLSPSR	Myc_N	protein degradation; molecular association, regulation; ubiquitination; intracellular localization; phosphorylation	cell differentiation, altered; cell growth, inhibited; apoptosis, induced; transcription, induced; transcription, altered	FBXW7(INDUCES); TUBA4A(DISRUPTS); Pin1(INDUCES)		643; 6122; 4625; 4862625; 3398504; 27519641; 13788312; 4966801; 5670; 7124707; 20834150; 4260502; 3689; 4749; 1926901; 4843009; 6504; 4862624	42	16	22		
Cdc37	Chaperone	Q16543	11140	CDC37	19p13.2	human	S13	PHOSPHORYLATION	450034	VWDHIEVsDDEDETH	CDC37_N	molecular association, regulation		HSP90A(INDUCES); HRI(INDUCES)		2597	5	8	0		
SRF	Motility/polarity/chemotaxis; Transcription factor	P11831	6722	SRF	6p21.1	human	S103	PHOSPHORYLATION	447692	RGLKRSLsEMEIGMV		molecular association, regulation	transcription, altered		DNA(INDUCES)	1645; 2277; 1646	13	1	5		
Mos	EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor)	P00536	17451	Mos		mouse	S72	PHOSPHORYLATION	448659	SVDSRSCsIPLVAPR		enzymatic activity, inhibited				2604	3	1	0	in vitro	
HEC1	Cell cycle regulation	O14777	10403	NDC80	18p11.32	human	S5	PHOSPHORYLATION	474510	___MKRSsVSSGGAG			cell cycle regulation			9229	1	0	0	mutation of six N-terminal residues (S5,S15,S44,T49,S55 and S69) to alanines interferes with mitosis	
PAK2	EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, STE; Protein kinase, Ser/Thr (non-receptor)	Q29502	100009535	PAK2		rabbit	T402	PHOSPHORYLATION	448300	PEQSKRStMVGTPYW	Pkinase	enzymatic activity, induced				6702318	13	2	9		
BAD	Apoptosis	Q61337	12015	Bad		mouse	S112	PHOSPHORYLATION	447860	ETRSRHSsYPAGTEE	Bcl-2_BAD	activity, induced; molecular association, regulation; intracellular localization	apoptosis, altered; apoptosis, inhibited	Bcl-xL(NOT_REPORTED); JNK1(DISRUPTS); 14-3-3 epsilon(INDUCES); PKACA(INDUCES); 14-3-3 beta(NOT_REPORTED); PPP2CA(INDUCES); 14-3-3 beta(INDUCES); Bcl-2(DISRUPTS); PKCA(INDUCES); Bcl-xL(DISRUPTS)		5289; 7550829; 6594; 460; 6597; 5732; 6445; 461; 2659; 2348; 4470; 7309807; 7098; 5325; 6072; 12662602; 4646618; 25255521; 6759; 5293; 4646619; 4478; 4646620; 4646626	113	9	164		
LIMK2	EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, Ser/Thr (non-receptor); Protein kinase, TKL	P53671	3985	LIMK2	22q12.2	human	T505	PHOSPHORYLATION	448683	NDRKKRYtVVGNPYW	Pkinase_Tyr	molecular association, regulation	cytoskeletal reorganization	ROCK2(INDUCES)		6390; 5930041	10	0	0		
ER-alpha	DNA binding protein; Nuclear receptor	P03372	2099	ESR1	6q25.1	human	K303	ACETYLATION	459012	LMIKRSKkNSLALSL		activity, induced; activity, inhibited	transcription, altered			11006907; 7602	4	0	0	K302/303A mutants are more active then wt protein at low concentration of E2 ; suppresses ligand sensitivity	
AHCYL1	Amino Acid Metabolism - cysteine and methionine; EC 3.3.1.1; Hydrolase; Other Amino Acids Metabolism - selenoamino acid	Q80SW1	229709	Ahcyl1		mouse	S74	PHOSPHORYLATION	467246	ISQSSTDsYSSAASY	Utp11	molecular association, regulation		IP3R1(INDUCES)		8190	3	1	0	binding to IP3R1 supresses its binding to IP3 and inhibits IP3-induced calcium release 	
Akt1	EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor)	P31749	207	AKT1	14q32.32	human	T450	PHOSPHORYLATION	447857	TAQMITItPPDQDDS	Pkinase_C	activity, induced; ubiquitination; enzymatic activity, inhibited; protein conformation; enzymatic activity, induced	cell differentiation, altered; translation, altered; apoptosis, induced; transcription, altered			13960500; 8910; 4768; 25091300; 15799300; 8911; 11751	22	0	1	prevents cotranslational Akt ubiquitination	
SLC12A3	Membrane protein, integral; Membrane protein, multi-pass; Transporter	P55017	6559	SLC12A3	16q13	human	S73	PHOSPHORYLATION	469631	TYEHYANsTQPGEPR	AA_permease_N	molecular association, regulation		ADD3(DISRUPTS)		17714504	8	2	1	ADD3 stimulates SLC12A3 activity	
MDM2	EC 6.3.2.-; EC 6.3.2.19; Inhibitor protein; Ligase; UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase	P23804	17246	Mdm2		mouse	T216	PHOSPHORYLATION	450150	SSSESTEtPSHQDLD		molecular association, regulation				2768	2	0	0		
FBXW7	Motility/polarity/chemotaxis; UBIQUITIN LIGASE; Ubiquitin conjugating system	Q969H0	55294	FBXW7	4q31.3	human	S10	PHOSPHORYLATION	17337000	QELLSVGsKRRRTGG		intracellular localization				15754912	1	1	0		
CARD11	Adaptor/scaffold	Q6KAS3	108723	Card11		mouse	S620	PHOSPHORYLATION	5403700	RYSFGPPsIHSSSSS		activity, inhibited				11419355	2	0	0		
RAF1	EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, Ser/Thr (non-receptor); Protein kinase, TKL	Q99N57	110157	Raf1		mouse	Y340	PHOSPHORYLATION	447749	RGQRDSSyYWEIEAS		phosphorylation; enzymatic activity, induced	apoptosis, altered			6534; 3340213	23	1	1	Bad Ser 112 + 136 phosphorylation	
MAP2 iso3	Cytoskeletal protein; Motility/polarity/chemotaxis	P15146-3	25595	Map2		rat	T220	PHOSPHORYLATION	2999205	ISSARRTtRSEPIRR	DUF1880	protein degradation; molecular association, regulation		TUBA1A(DISRUPTS); TUBB(DISRUPTS)		8621	1	0	0		
ADRB2	GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR	P18762	11555	Adrb2		mouse	S355	PHOSPHORYLATION	458916	KTYGNGYsSNSNGRT		receptor internalization, altered				1713110	15	0	0		
villin	Actin binding protein; Motility/polarity/chemotaxis	P09327	7429	VIL1	2q35	human	Y60	PHOSPHORYLATION	454005	KTASSLSyDIHYWIG	Gelsolin	molecular association, regulation; intracellular localization	cytoskeletal reorganization	ACTB(INDUCES)		4155; 8883	3	0	0		
Rb-like 2	Transcription, coactivator/corepressor	Q08999	5934	RBL2	16q12.2	human	T986	PHOSPHORYLATION	449737	QPSSAPPtPTRLTGA	RB_B	molecular association, regulation	cell cycle regulation	E2F4(DISRUPTS)		1200	3	10	6		
SLC38A3	Membrane protein, integral; Membrane protein, multi-pass; Transporter	Q9JHZ9	252919	Slc38a3		rat	S52	PHOSPHORYLATION	19001700	KGFLQQSsSKEPHFT		protein degradation; intracellular localization				18837509	1	0	0	protein internalization	
PPAR-gamma	DNA binding protein; Nuclear receptor	P37238	19016	Pparg		mouse	S112	PHOSPHORYLATION	448062	AIKVEPAsPPYYSEK		activity, inhibited	cell differentiation, altered; transcription, inhibited; cell growth, altered			21683716; 4214805; 5873; 4646623	14	0	0		
UBXN2B	Adaptor/scaffold; Endoplasmic reticulum	Q14CS0	137886	UBXN2B	8q12.1	human	S56	PHOSPHORYLATION	3217941	PKATVFKsPRTPPQR		molecular association, regulation; intracellular localization				15571609	1	3	4	 important for Golgi disassembly at mitosis; inhibits p37 binding to Golgi membranes	
RelB	Transcription factor	Q04863	19698	Relb		mouse	S368	PHOSPHORYLATION	455656	RLTDGVCsEPLPFTY		molecular association, regulation	transcription, altered	NFkB-p105(INDUCES); NFkB-p100(INDUCES)		6189	1	0	0		
AS160	GTPase activating protein, Rab	Q8BYJ6	210789	Tbc1d4		mouse	S595	PHOSPHORYLATION	455920	RMRGRLGsMDSFERA		phosphorylation				11390405	12	28	207	TBC1D4 S318/S588/T642/S751A mutation decreases phosphorylation of S711	
NFAT1	DNA binding protein; Transcription factor	Q60591	18019	Nfatc2		mouse	S177	PHOSPHORYLATION	447843	SPASSGSsASFISDT			transcription, inhibited			1188	0	1	0		
RIP140	Nuclear receptor co-regulator; Transcription, coactivator/corepressor	Q8CBD1	268903	Nrip1		mouse	Y364	PHOSPHORYLATION	25234802	SSPKNTSyKNSLERN		protein degradation; ubiquitination				25227607	1	0	0	regulates inflamatory responses and contributes to endotoxin tolerance	
WASP	Adaptor/scaffold; Motility/polarity/chemotaxis	P70315	22376	Was		mouse	Y293	PHOSPHORYLATION	447985	AETSKLIyDFIEDQG	PBD	activity, induced; protein stabilization	cell motility, altered; cytoskeletal reorganization; cell growth, altered			11554701; 4800	10	21	681	development of dsDNA auto antibodies and decrease podosome number in bone marrow cells in mutant mice	
MAPKAPK2	EC 2.7.1.-; EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, CAMK; Protein kinase, Ser/Thr (non-receptor)	P49138	17164	Mapkapk2		mouse	T320	PHOSPHORYLATION	448273	QSTKVPQtPLHTSRV		intracellular localization; enzymatic activity, induced				2602; 1316	21	4	19		
Cot	EC 2.7.11.25; KINASE; Kinase, protein; Protein kinase, STE; Protein kinase, Ser/Thr (non-receptor)	P41279	1326	MAP3K8	10p11.23	human	T290	PHOSPHORYLATION	455276	FPKDLRGtEIYMSPE	Pkinase	protein degradation; molecular association, regulation; phosphorylation; enzymatic activity, induced		NFkB-p105(DISRUPTS)		2865420; 5271; 4552	5	0	0	required for phosphorylation of Cot Ser62	
C/EBP-beta	DNA binding protein; Motility/polarity/chemotaxis; Transcription factor	P28033	12608	Cebpb		mouse	S184	PHOSPHORYLATION	455886	LSTSSSSsPPGTPSP		activity, induced; molecular association, regulation; protein conformation	cell cycle regulation; cell differentiation, altered; transcription, altered	C/EBP-beta(INDUCES)	DNA(INDUCES)	2653912; 6368; 1173006	8	6	0		
separase	EC 3.4.22.49; Protease	P60330	105988	Espl1		mouse	S1120	PHOSPHORYLATION	4270957	PIQSSVNsSPVLKTK		molecular association, regulation	cytoskeletal reorganization			28722139	1	0	0	S1120 T1341 AA mutant -fewer cold-stable kinetochore-microtubule attachments and lacks tension	
IGFBP1	Secreted; Secreted, signal peptide	P08833	3484	IGFBP1	7p13-p12	human	S126	PHOSPHORYLATION	451658	GSPESPEsTEITEEE		activity, induced; molecular association, regulation		IGF1(INDUCES)		4641413; 14081202; 3837	5	5	0		
Gab1	Adaptor/scaffold; Motility/polarity/chemotaxis	Q13480	2549	GAB1	4q31.21	human	Y589	PHOSPHORYLATION	449792	SHDSEENyVPMNPNL		molecular association, regulation		SHP-2(INDUCES); PIK3R1(INDUCES)		685; 2532	6	0	0		
SPHK2	EC 2.7.1.-; EC 2.7.1.91; Kinase, lipid; Lipid Metabolism - sphingolipid	Q9NRA0	56848	SPHK2	19q13.2	human	T614	PHOSPHORYLATION	477182	AFRLEPLtPRGVLTV			cell motility, altered			9377	1	1	0		
PEA-15	Apoptosis; Motility/polarity/chemotaxis	Q15121	8682	PEA15	1q21.1	human	S104	PHOSPHORYLATION	455750	TKLTRIPsAKKYKDI			autophagy, altered; signaling pathway regulation			14987304	7	9	308	PEA phosphorylation is required for JNK activity.	
GPLD1	EC 3.1.4.50; Glycan Metabolism - glycosylphosphatidylinositol (GPI)-anchor biosynthesis; Membrane protein, anchored; Phospholipase; Secreted; Secreted, signal peptide	P80109	287025	GPLD1		cow	T309	PHOSPHORYLATION	457382	NGFHKNVtAALTKNI		enzymatic activity, inhibited				7079	1	0	0		
CELF1	Cell development/differentiation; RNA binding protein; RNA processing	Q92879	10658	CELF1	11p11	human	S302	PHOSPHORYLATION	3347301	TSSGSSPsSSSSNSV		molecular association, regulation	translation, altered		RNA(INDUCES)	3309530	3	0	0	increases CUGBP1 binding to C/EBP beta and p21 mRNAs 	
PPP2CA	EC 3.1.3.16; Motility/polarity/chemotaxis; PHOSPHATASE; Protein phosphatase, Ser/Thr (non-receptor)	P63331	24672	Ppp2ca		rat	Y307	PHOSPHORYLATION	448571	VTRRTPDyFL_____		molecular association, regulation; enzymatic activity, inhibited		PPP2CB(DISRUPTS)		14790318; 11804	40	0	0		
ASK1	EC 2.7.11.25; KINASE; Kinase, protein; Protein kinase, STE; Protein kinase, Ser/Thr (non-receptor)	Q99683	4217	MAP3K5	6q22.33	human	T842	PHOSPHORYLATION	450004	CTETFTGtLQYMAPE	Pkinase		transcription, altered			970044	2	0	0		
Abl	EC 2.7.1.112; EC 2.7.10.2; KINASE; Kinase, protein; Protein kinase, TK; Protein kinase, tyrosine (non-receptor)	P00520	11350	Abl1		mouse	Y393	PHOSPHORYLATION	450298	RLMTGDTyTAHAGAK	Pkinase_Tyr	enzymatic activity, induced				5735; 998; 12482266	18	34	1682		
CaR	GPCR, family 3; Membrane protein, integral; Membrane protein, multi-pass; Motility/polarity/chemotaxis; Receptor, GPCR	P41180	846	CASR	3q13	human	T888	PHOSPHORYLATION	449862	FKVAARAtLRRSNVS		activity, induced; receptor desensitization, altered; activity, inhibited; phosphorylation				17714501; 8320; 9623; 2414; 2409; 11484401	7	1	0		
PDGFRA	EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Protein kinase, TK; Protein kinase, tyrosine (receptor)	P20786	25267	Pdgfra		rat	S751	PHOSPHORYLATION	23130540	MLERKEVsKYSDIQR	Pkinase_Tyr	molecular association, regulation		Nck1(INDUCES)		27257053	0	0	4		
AChE	EC 3.1.1.7; Hydrolase; Lipid Metabolism - glycerophospholipid; Membrane protein, anchored	P22303	43	ACHE	7q22	human	Y164	PHOSPHORYLATION	10799701	GASSLDVyDGRFLVQ	COesterase	enzymatic activity, induced				10816800	0	0	0		
IkB-epsilon	DNA binding protein; Inhibitor protein	O54910	18037	Nfkbie		mouse	S18	PHOSPHORYLATION	455580	ADDSQCDsGIESLRS		protein degradation				5520	1	1	4		
PDE4D iso2	EC 3.1.4.17; Nucleotide Metabolism - purine; Phosphodiesterase	Q08499-2	5144	PDE4D	5q12	human	S53	PHOSPHORYLATION	458388	VHSQRREsFLYRSDS		enzymatic activity, induced				8256; 12778805; 25785404	8	9	0	Phosphorylation of both dimer subunits in necessary for full PDE4D enzymatic activity.	
PKCE	EC 2.7.11.13; KINASE; Kinase, protein; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor)	Q02156	5581	PRKCE	2p21	human	S346	PHOSPHORYLATION	2807904	SEEDRSKsAPTSPCD		molecular association, regulation	cell cycle regulation; transcription, altered	14-3-3 beta(INDUCES)		2807209; 3301203	2	6	0		
H1E	DNA binding protein	P10412	3008	HIST1H1E	6p21.3	human	S36	PHOSPHORYLATION	456059	GAAKRKAsGPPVSEL	Linker_histone		cell cycle regulation		DNA(DISRUPTS)	21040924	1	33	29	 contributes to mitotic progression; dissociates from mitotic chromatin	
SRC-3	ACETYLTRANSFERASE; Acetyltransferase; EC 2.3.1.48; Motility/polarity/chemotaxis; Nuclear receptor co-regulator; Transcription, coactivator/corepressor	Q9Y6Q9	8202	NCOA3	20q12	human	K620	ACETYLATION	460610	LESKGHKkLLQLLTC	SRC-1	molecular association, regulation	transcription, inhibited	ER-alpha(DISRUPTS)		7504	1	0	0		
Kv2.1	Channel, cation; Channel, ligand-gated; Channel, potassium; Membrane protein, integral; Membrane protein, multi-pass	P15387	25736	Kcnb1		rat	S607	PHOSPHORYLATION	473555	EATRFSHsPLASLSS	Kv2channel	activity, inhibited				9216	5	4	0		
TrkA iso2	EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Protein kinase, TK; Protein kinase, tyrosine (receptor)	P04629-2	4914	NTRK1	1q21-q22	human	Y670	PHOSPHORYLATION	449759	FGMSRDIySTDYYRV	Pkinase_Tyr	enzymatic activity, induced				1305	2	1	13		
Fer	EC 2.7.10.2; KINASE; Kinase, protein; Protein kinase, TK; Protein kinase, tyrosine (non-receptor)	P70451	14158	Fer		mouse	Y402	PHOSPHORYLATION	457934	EPPPVVNyEEDARSV			cell cycle regulation; cell motility, altered			2790302	0	25	621		
smMLCK	EC 2.7.11.18; KINASE; Kinase, protein; Protein kinase, CAMK; Protein kinase, Ser/Thr (non-receptor)	Q15746	4638	MYLK	3q21	human	Y464	PHOSPHORYLATION	451414	QEGSIEVyEDAGSHY	I-set	molecular association, regulation; enzymatic activity, induced		cortactin(INDUCES)		8392; 12482245	3	1	0		
H3	DNA binding protein	P68433	360198	Hist1h3a		mouse	K28	TRI-METHYLATION	1308913	LATKAARkSAPATGG			transcription, altered			7550809	89	4	3		
vimentin	Cytoskeletal protein; Motility/polarity/chemotaxis	P20152	22352	Vim		mouse	S87	PHOSPHORYLATION	2301101	LQDSVDFsLADAINT	Filament_head; DUF2464; TPR_MLP1_2		cytoskeletal reorganization			2057	2	2	0		
PLZF	C2H2-type zinc finger protein; DNA binding protein; Transcription, coactivator/corepressor	Q05516	7704	ZBTB16	11q23.1	human	T282	PHOSPHORYLATION	2134716	RGKEGPGtPTRSSVI		protein degradation	cell cycle regulation; transcription, altered; cell growth, altered			2133205	1	2	1		
H3	DNA binding protein	P68431	8350	HIST1H3A	6p22.1	human	T12	PHOSPHORYLATION	455680	KQTARKStGGKAPRK			cell cycle regulation; transcription, altered			18378521	10	1	0		
NPM1	RNA binding protein; Translation	P06748	4869	NPM1	5q35.1	human	K292	ACETYLATION	8537511	QDLWQWRkSL_____		molecular association, regulation; intracellular localization	transcription, altered	H3(INDUCES)		8156707	1	1	0	K212/215/229/230/257/267/292R  mutant	
SIT	Adaptor/scaffold; Membrane protein, integral	Q9Y3P8	27240	SIT1	9p13-p12	human	Y169	PHOSPHORYLATION	448964	SGPEPELyASVCAQT		activity, inhibited				12668809	1	1	158	SIT inhibition of T cell activation	
PAK2	EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, STE; Protein kinase, Ser/Thr (non-receptor)	Q13177	5062	PAK2	3q29	human	S141	PHOSPHORYLATION	448295	TVKQKYLsFTPPEKD		enzymatic activity, induced				17675043	6	40	77		
Dok1	Adaptor/scaffold; Motility/polarity/chemotaxis	P97465	13448	Dok1		mouse	Y376	PHOSPHORYLATION	448368	PAPPRGLyDLPQEPR			cell cycle regulation; cell motility, altered			2790302	2	11	369		
PKCA	EC 2.7.11.13; KINASE; Kinase, protein; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor)	P17252	5578	PRKCA	17q22-q23.2	human	Y658	PHOSPHORYLATION	455927	SDFEGFSyVNPQFVH	Pkinase_C	intracellular localization				8113	4	0	0		
eIF4E	Translation; Translation initiation	P63073	13684	Eif4e		mouse	S209	PHOSPHORYLATION	447776	DTATKSGsTTKNRFV		molecular association, regulation; protein conformation	carcinogenesis, induced; translation, altered; cell growth, altered	eIF4G(INDUCES)		2343; 26374200; 3394317	42	1	0		
NFM	Cytoskeletal protein	P08553	18040	Nefm		mouse	S506	PHOSPHORYLATION	448042	AEKSPVKsPEAKEEE			cytoskeletal reorganization			7072905	4	2	6	slightly altered axoplasmic organization in 7S/A mice mutant	
CLOCK	ACETYLTRANSFERASE; Acetyltransferase; DNA binding protein; EC 2.3.1.48; Transcription factor	O08785	12753	Clock		mouse	S42	PHOSPHORYLATION	7911902	KRVSRNKsEKKRRDQ	HLH	protein degradation; intracellular localization	transcription, inhibited		DNA(DISRUPTS)	7889909	1	1	0	inhibits transcription	
LPCAT1	ACETYLTRANSFERASE; Acetyltransferase; EC 2.3.1.-; EC 2.3.1.23; EC 2.3.1.67; Endoplasmic reticulum; Membrane protein, integral	Q3TFD2	210992	Lpcat1		mouse	S182	PHOSPHORYLATION	17533101	VSRSDQDsRRKTVEE	Acyltransferase	protein degradation; ubiquitination				17431517	1	0	0		
Akt1	EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor)	Q01314	280991	AKT1		cow	S473	PHOSPHORYLATION	447855	RPHFPQFsYSASATA	Pkinase_C	activity, induced; intracellular localization; enzymatic activity, induced	cell growth, altered			4646617; 6939	1158	5	43	Translocation to the plasma membrane leads to phosphorylation. ; PI3K, Akt and mTOR activation are required for 5-HT-induced proliferatioin. Wortmanin LY294002 and NL-71-101 dose-dependently inhibited 5HT induced proliferation. 	
RSK4	EC 2.7.1.37; EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor)	Q9UK32	27330	RPS6KA6	Xq21	human	S372	PHOSPHORYLATION	457601	TAKTPKDsPGLPASA	Pkinase_C	enzymatic activity, induced				7130	1	2	1		
CDH5	Cell adhesion; Membrane protein, integral; Motility/polarity/chemotaxis	P55284	12562	Cdh5		mouse	S776	PHOSPHORYLATION	13258704	MLAELYGsDPQEELI	Cadherin_C	molecular association, regulation		PAR3(INDUCES)		13164202	1	0	0		
vimentin	Cytoskeletal protein; Motility/polarity/chemotaxis	P08670	7431	VIM	10p13	human	S51	PHOSPHORYLATION	449416	LRPSTSRsLYASSPG	Filament_head; DUF2464	molecular association, regulation	cytoskeletal reorganization	vimentin(DISRUPTS)		2214	5	25	39		
Rb-like 1	Transcription, coactivator/corepressor; Tumor suppressor	P28749	5933	RBL1	20q11.2	human	T369	PHOSPHORYLATION	451295	KRSFAPStPLTGRRY		molecular association, regulation	cell growth, altered	E2F4(DISRUPTS)		3519; 5981	2	7	29		
CD22	Cell surface; Membrane protein, integral	P35329	12483	Cd22		mouse	Y811	PHOSPHORYLATION	459310	NNSDSVTySVIQKRP		molecular association, regulation; phosphorylation		SHP-1(INDUCES)		1172849	2	1	5		
SNAP23	Vesicle protein	O09044	20619	Snap23		mouse	S95	PHOSPHORYLATION	455262	NRTKNFEsGKNYKAT	SNAP-25	molecular association, regulation	exocytosis, altered	STX11(INDUCES)		4049520; 27902355	5	2	1	required for IKK2-mediated mast cells degranulation; membrane fusion, SNARE complex formation, hemostasis	
CUL3	Cell cycle regulation; Ubiquitin conjugating system; Ubiquitin ligase	Q13618	8452	CUL3	2q36.2	human	Y764	PHOSPHORYLATION	25180500	TPEDRKVyTYVA___		intracellular localization				25082853	1	0	0		
IFNAR2	Membrane protein, integral; Receptor, cytokine	P48551	3455	IFNAR2	21q22.11	human	Y512	PHOSPHORYLATION	3063304	DVDLGDGyIMR____		activity, induced; phosphorylation	transcription, induced; transcription, altered			12028127; 25779402; 8565	3	0	0	STAT phosphorylation and activation; lack of STAT1, 2, 3 phosphorylation in IFNAR2 Y337/512F mutant; IFN induced STAT activation and induced transcription 	
Ret	EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Protein kinase, TK; Protein kinase, tyrosine (receptor)	P35546	19713	Ret		mouse	Y1063	PHOSPHORYLATION	447625	TWIENKLyGMSDPNW		molecular association, regulation	cytoskeletal reorganization	Dok5(INDUCES); Dok2(INDUCES); Dok1(INDUCES); Dok4(INDUCES)		5869; 2629	36	0	2		
CREB	DNA binding protein; Transcription factor	P15337	81646	Creb1		rat	S117	PHOSPHORYLATION	451810	DSQESVDsVTDSQKR	pKID	protein degradation				8156	4	0	0	required for PDGF-induced protein ubiquitination	
MSK1	EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor)	Q8C050	73086	Rps6ka5		mouse	S375	PHOSPHORYLATION	448216	ERLFQGYsFVAPSIL	Pkinase_C	enzymatic activity, induced				2661902	20	12	35		
syndecan-2	Cell adhesion; Cell surface; Membrane protein, integral; Motility/polarity/chemotaxis	P34741	6383	SDC2	8q22-q23	human	Y179	PHOSPHORYLATION	448375	RKKDEGSyDLGERKP	Glycophorin_A; Herpes_gE; Syndecan; Protocadherin	molecular association, regulation		RACK1(INDUCES)		8960	2	1	6		
EHHADH	Amino Acid Metabolism - lysine degradation; Amino Acid Metabolism - tryptophan; Amino Acid Metabolism - valine, leucine and isoleucine degradation; Carbohydrate Metabolism - butanoate; Carbohydrate Metabolism - propanoate; EC 1.1.1.35; EC 4.2.1.17; EC 5.3.3.8; Isomerase; Lipid Metabolism - fatty acid; Lyase; Mitochondrial; Other Amino Acids Metabolism - beta-alanine; Oxidoreductase; Secondary Metabolites Metabolism - limonene and pinene degradation	Q08426	1962	EHHADH	3q26.3-q28	human	K584	ACETYLATION	461837	KGWYQYDkPLGRIHK		enzymatic activity, induced				12513600	0	5	24		
CD5	Cell surface; Membrane protein, integral	P13379	12507	Cd5		mouse	Y464	PHOSPHORYLATION	450105	RNSHLSAyPALEGAL		molecular association, regulation		PIK3R1(NOT_REPORTED)		2710	1	0	18		
ASK1	EC 2.7.11.25; KINASE; Kinase, protein; Protein kinase, STE; Protein kinase, Ser/Thr (non-receptor)	O35099	26408	Map3k5		mouse	S973	PHOSPHORYLATION	447736	NEYLRSIsLPVPVLV			transcription, altered			11999212	12	1	1		
p53	Activator protein; DNA binding protein; Motility/polarity/chemotaxis; Nuclear receptor co-regulator; Transcription factor; Tumor suppressor	P10361	24842	Tp53		rat	S376	PHOSPHORYLATION	447534	TKKGQSTsRHKKPMI		activity, induced				6472	14	1	0		
SLC25A5	Membrane protein, integral; Membrane protein, multi-pass; Mitochondrial; Transporter	P05141	292	SLC25A5	Xq24	human	Y195	PHOSPHORYLATION	458470	RAAYFGIyDTAKGML	Mito_carr; TM	molecular association, regulation		Nck2(NOT_REPORTED)		27932900	0	11	137		
CCNE1	Activator protein; Nuclear receptor co-regulator	Q61457	12447	Ccne1		mouse	T74	PHOSPHORYLATION	454411	DPCSFIPtPNKEEDN		protein degradation; activity, inhibited	cell cycle regulation; cell differentiation, altered; cell growth, altered			4313611	5	1	0	T74A/T393A mutation causes increased Cdk2 kinase activity and stability and regulation by Fbw7. 	
PTEN	Carbohydrate Metabolism - inositol phosphate; EC 3.1.3.16; EC 3.1.3.48; EC 3.1.3.67; Motility/polarity/chemotaxis; Nuclear receptor co-regulator; PHOSPHATASE; Phosphatase, lipid; Tumor suppressor	P60484	5728	PTEN	10q23.3	human	S370	PHOSPHORYLATION	448649	TSVTPDVsDNEPDHY		protein stabilization; enzymatic activity, inhibited		PTEN(DISRUPTS)		1252602; 2904	9	4	0		
adrenodoxin	Mitochondrial	P00257	281157	FDX1		cow	T129	PHOSPHORYLATION	455475	FEKLEAItDEENDML	Fer2; zf-CHY	molecular association, regulation		CYP11A1(INDUCES)		9622; 5230	2	1	0		
eIF4E	Translation; Translation initiation	P06730	1977	EIF4E	4q21-q25	human	T210	PHOSPHORYLATION	450199	TATKSGStTKNRFVV			cell growth, altered			7324113	3	2	0	S209A/T210A mutant showed reduced transport of cyclin D1 mRNA from nucleus to cytoplasm.  eiF4E cellular distribution not affected by phosphorylation. 	
ChAT iso3	ACETYLTRANSFERASE; Acetyltransferase; EC 2.3.1.6; Lipid Metabolism - glycerophospholipid	P28329-3	1103	CHAT	10q11.2	human	S347	PHOSPHORYLATION	454036	LKHVTQSsRKLIRAD	Carn_acyltransf	enzymatic activity, induced				4182	1	0	0		
MEK1	EC 2.7.12.2; KINASE; Kinase, protein; Protein kinase, STE; Protein kinase, dual-specificity	P31938	26395	Map2k1		mouse	S222	PHOSPHORYLATION	448513	LIDSMANsFVGTRSY	Pkinase	enzymatic activity, induced	cell growth, altered			6759; 1740; 4914026	85	9	183		
PDK1	EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor)	O15530	5170	PDPK1	16p13.3	human	S398	PHOSPHORYLATION	12729601	SSSSHSLsASDTGLP			apoptosis, altered; cell growth, altered			11999212	2	0	0		
Cdc25B	EC 3.1.3.48; Motility/polarity/chemotaxis; Nuclear receptor co-regulator; PHOSPHATASE; Protein phosphatase, dual-specificity	P30305	994	CDC25B	20p13	human	S375	PHOSPHORYLATION	455380	ARVLRSKsLCHDEIE	M-inducer_phosp	molecular association, regulation		14-3-3 beta(INDUCES)		6576	4	9	2		
lamin A/C	Cytoskeletal protein	P02545	4000	LMNA	1q22	human	S390	PHOSPHORYLATION	452605	EEERLRLsPSPTSQR	DUF3584; IncA	activity, induced; intracellular localization				4641430	4	68	125	nuclear lamin disassemby	
MCM2	DNA binding protein; EC 3.6.4.12	P49736	4171	MCM2	3q21	human	S40	PHOSPHORYLATION	452311	RRTDALTsSPGRDLP		molecular association, regulation	chromatin organization, altered; cell growth, altered		DNA(INDUCES)	9204; 9145	5	15	17	MMCM2 phosphorylated forms are differentially bound to chromatin. 	
FAK	EC 2.7.1.112; EC 2.7.10.2; KINASE; Kinase, protein; Protein kinase, TK; Protein kinase, tyrosine (non-receptor)	Q05397	5747	PTK2	8q24.3	human	S732	PHOSPHORYLATION	450196	SSEGFYPsPQHMVQT			cell motility, altered; cell adhesion, altered			8085	5	1	0	triggers the formation of the ventral focal adhesions	
TAZ	Transcription, coactivator/corepressor	Q9EPK5	97064	Wwtr1		mouse	S89	PHOSPHORYLATION	457660	AQHVRSHsSPASLQL		molecular association, regulation	transcription, inhibited	14-3-3 epsilon(INDUCES)		6581	5	6	73		
StAR	Carrier protein; Lipid binding protein; Mitochondrial	P49675	6770	STAR	8p11.2	human	S195	PHOSPHORYLATION	450442	RCAKRRGsTCVLAGM	START	activity, induced				12668801	7	0	0		
MC1R	GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR	Q01726	4157	MC1R	16q24.3	human	S316	PHOSPHORYLATION	471420	LKEVLTCsW______		receptor internalization, altered				9118	1	0	0	T308 and S316 phosphorylation regulate MC1R internalization and desensitization. 	
PDGFRB	EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Protein kinase, TK; Protein kinase, tyrosine (receptor)	P09619	5159	PDGFRB	5q33.1	human	Y771	PHOSPHORYLATION	447517	ADIESSNyMAPYDNY	Pkinase_Tyr	molecular association, regulation		Shc1(INDUCES); RASA1(INDUCES)		6024; 2280; 1230; 7324108; 1843	12	2	5		
CACNG2	Channel, calcium; Membrane protein, integral; Membrane protein, multi-pass	O88602	12300	Cacng2		mouse	S221	PHOSPHORYLATION	2047941	ATDYLQAsAITRIPS	AA_permease_2; Tetraspannin	intracellular localization				22913905	0	3	0	AMPAR immobilization in synaptic membrane	
GRK2	EC 2.7.11.15; KINASE; Kinase, protein; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor)	Q99MK8	110355	Adrbk1		mouse	Y86	PHOSPHORYLATION	447727	AKPLVEFyEEIKKYE	RGS		cell motility, altered			2425208	5	0	0		
skMLCK	EC 2.7.11.18; KINASE; Kinase, protein; Motility/polarity/chemotaxis; Protein kinase, CAMK; Protein kinase, Ser/Thr (non-receptor)	P20689	117558	Mylk2		rat	S168	PHOSPHORYLATION	2864200	PAFLHSPsCPAIISC		molecular association, regulation		14-3-3 beta(INDUCES)		2852661	2	2	0		
claspin	Actin binding protein; Cell cycle regulation	Q9HAW4	63967	CLSPN	1p34.2	human	T916	PHOSPHORYLATION	455334	DELLDLCtGKFTSQA		molecular association, regulation	chromatin organization, altered	Chk1(INDUCES)		9121; 4600	2	0	0	regulates Chk1 activity in response to hydroxyurea	
Bcr	EC 2.7.11.1; GTPase activating protein, Rac/Rho; KINASE; Kinase, protein; Protein kinase, ATYPICAL; Protein kinase, Ser/Thr (non-receptor)	P11274	613	BCR	22q11.23	human	S354	PHOSPHORYLATION	447791	SGQSSRVsPSPTTYR		molecular association, regulation	apoptosis, induced	Abl iso2(INDUCES)		1752	3	5	58		
IKKB	EC 2.7.11.10; KINASE; Kinase, protein; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor)	O14920	3551	IKBKB	8p11.2	human	Y188	PHOSPHORYLATION	449632	SFVGTLQyLAPELLE	Pkinase	activity, induced	transcription, altered			2269; 5591	4	0	0		
Rb	Nuclear receptor co-regulator; Transcription, coactivator/corepressor; Tumor suppressor	P06400	5925	RB1	13q14.2	human	S788	PHOSPHORYLATION	450022	PIPHIPRsPYKFPSS	Rb_C	molecular association, regulation	cell growth, altered	E2F1(DISRUPTS); TFDP1(DISRUPTS)		7267; 777	8	9	65		
FAK	EC 2.7.1.112; EC 2.7.10.2; KINASE; Kinase, protein; Protein kinase, TK; Protein kinase, tyrosine (non-receptor)	Q05397	5747	PTK2	8q24.3	human	Y407	PHOSPHORYLATION	447888	IIDEEDTyTMPSTRD		enzymatic activity, induced	cell motility, altered; cytoskeletal reorganization; cell adhesion, altered			8085; 4894707; 4445	27	11	135		
XRCC1	DNA repair	P18887	7515	XRCC1	19q13.2	human	T284	PHOSPHORYLATION	5014905	APTRTPAtAPVPARA		activity, induced; molecular association, regulation	cell growth, altered	MPG(INDUCES); CCNO(INDUCES)		5007915	1	0	0	promotes base excision repair	
Ebp1	Nuclear receptor co-regulator; Transcription, coactivator/corepressor	Q9UQ80	5036	PA2G4	12q13.2	human	T261	PHOSPHORYLATION	2303906	QYGLKMKtSRAFFSE	Peptidase_M24	activity, inhibited	cell growth, induced; transcription, induced			2198903	2	0	0		
SSB1	Adaptor/scaffold	Q96BD6	80176	SPSB1	1p36.22	human	Y31	PHOSPHORYLATION	455116	QELQGLDyCKPTRLD		molecular association, regulation		RASA1(INDUCES)		12482293	1	0	0		
KIF2C	Cancer Testis Antigen (CTA); Microtubule binding protein; Motility/polarity/chemotaxis; Motor protein	Q99661	11004	KIF2C	1p34.1	human	S109	PHOSPHORYLATION	2132103	APKESLRsRSTRMST		molecular association, regulation; intracellular localization; activity, inhibited	cytoskeletal reorganization	EB1(DISRUPTS)		9985931; 3306	2	0	0	involved in microtubule tip tracking 	
MEKK1	EC 2.7.11.25; EC 6.3.2.-; KINASE; Kinase, protein; Ligase; Protein kinase, STE; Protein kinase, Ser/Thr (non-receptor); UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase	P53349	26401	Map3k1		mouse	T1381	PHOSPHORYLATION	448078	ARLASKGtGAGEFQG	Pkinase	enzymatic activity, induced				2695	2	0	0		
RAF1	EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, Ser/Thr (non-receptor); Protein kinase, TKL	Q99N57	110157	Raf1		mouse	S621	PHOSPHORYLATION	447746	PKINRSAsEPSLHRA		protein stabilization; molecular association, regulation		14-3-3 beta(INDUCES)		2268; 6115935	22	35	9		
AR	DNA binding protein; Nuclear receptor; Transcription factor	P10275	367	AR	Xq12	human	S213	PHOSPHORYLATION	448577	SGRAREAsGAPTSSK	Androgen_recep	intracellular localization; activity, inhibited	apoptosis, inhibited; transcription, altered			2855907; 920	8	0	0	Mutation reduces transport to the nucleus. S213A and S791A mutations reduce  binding to androgen. 	
Bcl-xL	Apoptosis; Autophagy; Membrane protein, integral; Mitochondrial	Q07817	598	BCL2L1	20q11.21	human	S62	PHOSPHORYLATION	449099	PSWHLADsPAVNGAT		molecular association, regulation; intracellular localization	cell cycle regulation; apoptosis, altered; apoptosis, induced	Bax(DISRUPTS); CDK1(DISRUPTS)		2129; 6115915; 6328006; 25582505; 14664804; 9621	10	1	0		
XRCC1	DNA repair	P18887	7515	XRCC1	19q13.2	human	S371	PHOSPHORYLATION	458811	FANTPKYsQVLGLGG	BRCT	molecular association, regulation		XRCC1(DISRUPTS)		7449	1	0	1		
RENT1	C2H2-type zinc finger protein; EC 3.6.1.-; EC 3.6.4.-; Hydrolase	Q9EPU0	19704	Upf1		mouse	S1084	PHOSPHORYLATION	12559503	GLSQPELsQDSYLGD		molecular association, regulation		STAU(INDUCES)		25347006	4	0	0	 increases Stau1-mediated decay of mRNA; regulates adipogenesis	
CARD11	Adaptor/scaffold	Q6KAS3	108723	Card11		mouse	S657	PHOSPHORYLATION	457639	LERPFRPsVTSGGHV		activity, induced; molecular association, regulation		Bcl-10(INDUCES)		7271; 11419355	4	0	0		
RasGRF1	Guanine nucleotide exchange factor, Ras	P28818	192213	Rasgrf1		rat	S898	PHOSPHORYLATION	448487	KEIYRRMsLANTGYS	RasGEF_N	activity, induced; intracellular localization	cytoskeletal reorganization; cell growth, altered			1919	3	0	0		
Destrin	Actin binding protein; Motility/polarity/chemotaxis	P60981	11034	DSTN	20p12.1	human	S3	PHOSPHORYLATION	449754	_____MAsGVQVADE			cytoskeletal reorganization; cell adhesion, altered			6390	4	20	1		
ARAF	EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, Ser/Thr (non-receptor); Protein kinase, TKL	P10398	369	ARAF	Xp11.4-p11.2	human	T442	PHOSPHORYLATION	3306325	IFLHEGLtVKIGDFG	Pkinase_Tyr	enzymatic activity, induced				3301229	0	1	0		
WWOX	Apoptosis; EC 1.1.1.-; Oxidoreductase	Q9NZC7	51741	WWOX	16q23.3-q24.1	human	Y33	PHOSPHORYLATION	449043	TTKDGWVyYANHTEE	WW	molecular association, regulation; intracellular localization; enzymatic activity, induced	apoptosis, altered; apoptosis, induced	HYAL2(INDUCES); JNK1(DISRUPTS); p53(INDUCES); p73(INDUCES); JNK1(INDUCES)		7889907; 8894; 4441; 2076; 7146; 2451811; 7025	12	0	0	induced by TGF-beta1; dn-JNK1 induces WOX1 phosphorylation	
FcER1B	Membrane protein, integral; Membrane protein, multi-pass; Receptor, misc.	Q01362	2206	MS4A2	11q12-q13	human	Y219	PHOSPHORYLATION	454405	KVPEDRVyEELNIYS		molecular association, regulation		Lyn(INDUCES)		4272	1	1	0		
COL17A1	Extracellular matrix; Membrane protein, integral; Motility/polarity/chemotaxis	Q9UMD9	1308	COL17A1	10q24.3	human	S542	PHOSPHORYLATION	484006	LDKIGLHsDSQEELW			cell adhesion, altered			11957	1	0	0	regulates COL17A1 shedding of ectodomain	
CCT2	Chaperone	P80314	12461	Cct2		mouse	S260	PHOSPHORYLATION	472352	GSRVRVDsTAKVAEI	Cpn60_TCP1	molecular association, regulation				18898716	2	9	241	chaperonin protein folding 	
Cbl	Adaptor/scaffold; EC 6.3.2.-; EC 6.3.2.19; Ligase; Motility/polarity/chemotaxis; UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase	P22681	867	CBL	11q23.3	human	S619	PHOSPHORYLATION	4704596	RELTNRHsLPFSLPS		molecular association, regulation		14-3-3 eta(INDUCES)		10144203	0	5	17		
STLK3	EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, STE; Protein kinase, Ser/Thr (non-receptor)	Q9Z1W9	53416	Stk39		mouse	S383	PHOSPHORYLATION	456506	VRRVPGSsGHLHKTE		enzymatic activity, induced				17630301	10	9	1		
VEGFR3	EC 2.7.1.112; EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Protein kinase, TK; Protein kinase, tyrosine (receptor)	P35916	2324	FLT4	5q35.3	human	Y1337	PHOSPHORYLATION	2874406	QVFYNSEyGELSEPS		molecular association, regulation; enzymatic activity, induced	cell motility, induced; cell growth, induced	Shc1(INDUCES); Crk(INDUCES)		25699200; 13974107	4	1	2		
PICH	EC 3.6.1.-; EC 3.6.4.12; Helicase	Q2NKX8	54821	ERCC6L	Xq13.1	human	T1063	PHOSPHORYLATION	474544	VKQFDAStPKNDISP		intracellular localization				9277	1	4	4	required for checkpoint signaling and proper sister chromosomes segregation	
RUFY1	Ubiquitin conjugating system	Q96T51	80230	RUFY1	5q35.3	human	Y400	PHOSPHORYLATION	451278	RQGLDEMySDVWKQL	DUF972	intracellular localization				3500	1	1	23		
LKB1	Autophagy; EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, CAMK; Protein kinase, Ser/Thr (non-receptor)	Q9WTK7	20869	Stk11		mouse	S431	PHOSPHORYLATION	448147	SNKIRRLsACKQQ__		phosphorylation; enzymatic activity, induced	cytoskeletal reorganization; cell growth, altered	BRSK1(INDUCES); AMPKA1(INDUCES); tau(INDUCES)		1193006; 2329	21	2	0	AMPK T174-p was not affected by loss of LKB1 in cortical neurons.; LKB1 phosphorylates Brsk1 and Brsk2.; Tau S262 is phosphoryated by LKB1 only in the presence of BRSK2. 	
PHKB	KINASE; Protein kinase, regulatory subunit	P12798	100009137	PHKB		rabbit	S27	PHOSPHORYLATION	470138	ARTKRSGsVYEPLKS		molecular association, regulation				9028	1	11	5	Mutations of S12 and S27 increased Beta subunit self interactions.	
Kv7.3	Channel, potassium; Membrane protein, integral; Membrane protein, multi-pass	O43525	3786	KCNQ3	8q24	human	T246	PHOSPHORYLATION	457688	RMDRRGGtWKLLGSA	Ion_trans; TM	activity, induced				7320	1	1	0		
SHIP	EC 3.1.3.86; EC 3.1.3.n1; Motility/polarity/chemotaxis; Phosphatase, lipid	Q92835	3635	INPP5D	2q37.1	human	Y865	PHOSPHORYLATION	454794	GKTREKLyDFVKTER		molecular association, regulation		SH2D1B(NOT_REPORTED)		27932900	0	14	374		
Smc1	DNA replication; RNA splicing	Q14683	8243	SMC1A	Xp11.22-p11.21	human	S966	PHOSPHORYLATION	448698	GEDSVSGsQRISSIY	SMC_N	molecular association, regulation; intracellular localization	cell cycle regulation; cytoskeletal reorganization	RAE1(INDUCES)		3186; 6271034; 1871	18	8	63		
SGO1	Cell cycle regulation	Q9CXH7	72415	Sgol1		mouse	S73	PHOSPHORYLATION	2535906	LALENEKsKVREAQD	DUF2491	intracellular localization				2425200	1	0	0	S73A and T146A mutants do not localize to the spindle pole region	
TPH1	Amino Acid Metabolism - tryptophan; EC 1.14.16.4; Oxidoreductase	P09810		Tph1		rat	S58	PHOSPHORYLATION	451575	RKSKRRNsEFEIFVD	ACT	enzymatic activity, induced				10167116	3	0	0		
DAPK1	Apoptosis; Autophagy; EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, CAMK; Protein kinase, Ser/Thr (non-receptor)	Q80YE7	69635	Dapk1		mouse	S308	PHOSPHORYLATION	448142	ARKKWKQsVRLISLC		protein degradation; molecular association, regulation; enzymatic activity, inhibited	apoptosis, altered; apoptosis, induced	CHIP(DISRUPTS); MIB1(DISRUPTS); calmodulin(DISRUPTS)		2626202; 12558704; 7169; 10274600; 1173032	7	1	0		
FOXO1A	DNA binding protein; Nuclear receptor co-regulator; Transcription factor	Q12778	2308	FOXO1	13q14.1	human	T24	PHOSPHORYLATION	448560	LPRPRSCtWPLPRPE		molecular association, regulation; intracellular localization; phosphorylation	transcription, altered; transcription, inhibited	14-3-3 beta(INDUCES); 14-3-3 zeta(INDUCES); 14-3-3 gamma(INDUCES)		6791; 677; 15022750; 4904514; 2463200; 12525214; 3405	46	3	36		
SIPA1L1	GTPase activating protein, Ras	O35412	246212	Sipa1l1		rat	T1348	PHOSPHORYLATION	26348504	SADSGIDtASYGLSH		protein degradation; molecular association, regulation; ubiquitination		BTRC(INDUCES)		25785421	1	0	0		
NEK2	EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor)	P51955	4751	NEK2	1q32.2-q41	human	T170	PHOSPHORYLATION	4271902	ARILNHDtSFAKTFV	Pkinase	enzymatic activity, induced				12482404	1	1	0		
doublecortin iso2	Cytoskeletal protein; Motility/polarity/chemotaxis	O43602-2	1641	DCX	Xq22.3-q23	human	S334	PHOSPHORYLATION	451359	SPISTPTsPGSLRKH		intracellular localization	cell motility, altered; cytoskeletal reorganization			8909	3	4	18	affects doublecortin localization to growth cones, neurite outgrowth, and neuronal motility	
ERK1	EC 2.7.1.123; EC 2.7.11.24; KINASE; Kinase, protein; Protein kinase, CMGC; Protein kinase, Ser/Thr (non-receptor)	P21708	50689	Mapk3		rat	T203	PHOSPHORYLATION	447542	HDHTGFLtEYVATRW	Pkinase; YukC	activity, induced; intracellular localization; enzymatic activity, induced	translation, altered; cell growth, altered			6295; 4862613; 3764; 5955619; 7472; 19016901; 7848; 13788306; 5755; 7910522; 5718	994	51	1957	regulate cell proliferation in dentate gyrus following ischemia;  phenylphrine induces protein synthesis; colocalized in glucose induced filipodia extensions, leading to insulin secretion	
GIT2	GTPase activating protein, ARF; Motility/polarity/chemotaxis	Q9Y621	374035	GIT2		chicken	Y392	PHOSPHORYLATION	456754	QDNDQPDyDSVASDE		molecular association, regulation; intracellular localization	cell adhesion, altered	PXN(INDUCES)		6868	1	3	25		
PLK1	EC 2.7.11.21; KINASE; Kinase, protein; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor)	P53350	5347	PLK1	16p12.2	human	S137	PHOSPHORYLATION	448138	LELCRRRsLLELHKR	Pkinase	enzymatic activity, induced	cell cycle regulation			5273; 1766	4	2	0		
RhoU	G protein; G protein, monomeric, Rho; Motility/polarity/chemotaxis	Q7L0Q8	58480	RHOU	1q42.11-q42.3	human	Y254	PHOSPHORYLATION	14918203	SKSWWKKyCCFV___		molecular association, regulation; intracellular localization; activity, inhibited	cytoskeletal reorganization; cell growth, altered	PAK1(DISRUPTS)		14780528	1	0	0		
EphA5	EC 2.7.1.112; EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Protein kinase, TK; Protein kinase, tyrosine (receptor)	Q60629	13839	Epha5		mouse	Y672	PHOSPHORYLATION	451542	EDDPEAAyTTRGGKI	Pkinase_Tyr		cell cycle regulation; cell motility, altered			2790302	0	20	724		
Bcl-6	C2H2-type zinc finger protein; Transcription factor	P41182	604	BCL6	3q27	human	S333	PHOSPHORYLATION	447600	KGLVSPQsPQKSDCQ		protein degradation				9139	1	7	25		
HDAC1	EC 3.5.1.98; Hydrolase; Nuclear receptor co-regulator	Q13547	3065	HDAC1	1p34	human	S423	PHOSPHORYLATION	447913	CEEEFSDsEEEGEGG	SDA1	molecular association, regulation; enzymatic activity, induced		SIN3A(INDUCES)		1395	1	35	35		
GYS1	Carbohydrate Metabolism - starch and sucrose; EC 2.4.1.11; Transferase	P13807	2997	GYS1	19q13.3	human	S8	PHOSPHORYLATION	449898	MPLNRTLsMSSLPGL		enzymatic activity, inhibited				7543506	15	1	0		
ETV1	DNA binding protein; Transcription factor	P41164	14009	Etv1		mouse	S216	PHOSPHORYLATION	3059600	PMYQRQMsEPNIPFP	ETS_PEA3_N	activity, inhibited	transcription, altered			8496	3	1	1	in Mv1Lu cells (mutation shows no effect in HeLa cells)	
Abi-1	Adaptor/scaffold; Motility/polarity/chemotaxis	Q8IZP0	10006	ABI1	10p11.2	human	S183	PHOSPHORYLATION	486178	PPTQKPPsPPMSGRG		molecular association, regulation	cell motility, altered; cytoskeletal reorganization			18668222	1	33	48	regulates WRC (WAVE2 regulatory complex) interaction with Arp2/3 and lamellipodial protrusion	
Kizuna	Cell cycle regulation	Q2M2Z5	55857	PLK1S1	20p11.23	human	T379	PHOSPHORYLATION	469605	WSTSSDLtISISEDD			cytoskeletal reorganization			8903	1	0	0	stabilizes mitotic centrosomes	
ITGA3	Cell adhesion; Membrane protein, integral; Motility/polarity/chemotaxis; Receptor, misc.	P26006	3675	ITGA3	17q21.33	human	S1042	PHOSPHORYLATION	447602	AEMKSQPsETERLTD	DUF1191	molecular association, regulation; intracellular localization	cytoskeletal reorganization; cell adhesion, altered			1684	1	3	0		
PKCD	EC 2.7.10.2; EC 2.7.11.13; KINASE; Kinase, protein; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor)	Q05655	5580	PRKCD	3p21.31	human	T295	PHOSPHORYLATION	4272376	AEALNQVtQRASRRS		enzymatic activity, induced				7549218	1	1	0		
TBC1D1	GTPase activating protein, Rab; Ubiquitin-specific protease	Q86TI0	23216	TBC1D1	4p14	human	S237	PHOSPHORYLATION	2103609	RPMRKSFsQPGLRSL		molecular association, regulation		14-3-3 sigma(INDUCES)		1968306	5	19	73		
FcER1B	Membrane protein, integral; Membrane protein, multi-pass; Receptor, misc.	P13386	25316	Ms4a2		rat	Y218	PHOSPHORYLATION	454405	KVPDDRLyEELHVYS	SUR7	molecular association, regulation		Shc1(INDUCES); Syk(INDUCES); SHIP(INDUCES); SHP-1(INDUCES); Grb2(INDUCES)		2875302	1	1	0	SHIP binding is senstive to the presence of Syk.	
JIP1	Adaptor/scaffold	Q9WVI9	19099	Mapk8ip1		mouse	S417	PHOSPHORYLATION	458259	DNCASASsPYESAIG			cell motility, induced	KIF5A(INDUCES)		28722415	2	1	0	increased anterograde amyloid precursor protein (APP) transport, decreased retrograde run length	
FAM129A	Unknown function	Q9BZQ8	116496	FAM129A	1q25	human	S602	PHOSPHORYLATION	467580	ASPARRAsAILPGVL			apoptosis, inhibited	NPM1(INDUCES)		25227643	1	20	26	FAM129 phosphorylation disrupts binding of NPM to MDM2 and promotes MDM2-p53 interaction, leading to p53 degredation.	
VEGFR2	EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Protein kinase, TK; Protein kinase, tyrosine (receptor)	P35968	3791	KDR	4q11-q12	human	Y1175	PHOSPHORYLATION	447901	AQQDGKDyIVLPISE		molecular association, regulation; enzymatic activity, induced; phosphorylation	signaling pathway regulation; transcription, altered; cell growth, altered	Shc1(INDUCES); PLCG1(INDUCES); Shc2(INDUCES); Shb(INDUCES)		5955626; 8796; 699; 5179; 2708101; 2712; 2624804; 2986	24	0	0	in chimeric receptor, essential for PLC-gamma activation	
ADCY6	Adenylyl cyclase; EC 4.6.1.1; Lyase; Membrane protein, integral; Membrane protein, multi-pass; Nucleotide Metabolism - purine	AAA40678	25289	Adcy6		rat	S744	PHOSPHORYLATION	467272	PNALQRLsRSIVRSR		enzymatic activity, induced				8212; 8211	2	0	0		
CLIC5	Membrane protein, integral; Motility/polarity/chemotaxis	Q9NZA1	53405	CLIC5	6p12.3	human	Y33	PHOSPHORYLATION	3081200	EENESPHyDDVHEYL		activity, induced; molecular association, regulation		Fyn(INDUCES)		8709	1	0	0		
53BP1	Transcription, coactivator/corepressor	Q12888	7158	TP53BP1	15q15-q21	human	S25	PHOSPHORYLATION	450163	PCLIIEDsQPESQVL			apoptosis, altered			14989305	3	0	0		
PSD-95	Adaptor/scaffold	P31016	29495	Dlg4		rat	S418	PHOSPHORYLATION	456447	LMNSSLGsGTASLRS		protein conformation		CRIPT(DISRUPTS)		21385507	1	10	1	Y397E mutant showed dissociation, and triple mutant Y397E/S415E/S418E, had stronger dissociation. 	
HIPK2	EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, CMGC; Protein kinase, Ser/Thr (non-receptor)	Q9H2X6	28996	HIPK2	7q32-q34	human	K805	UBIQUITINATION	3059903	TTSSRKSkQHQSSVR		protein degradation				2831762	1	0	0		
AT1	GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR	P25095	24180	Agtr1		rat	S348	PHOSPHORYLATION	452093	PSDNMSSsAKKPASC		activity, induced				8139	2	0	0		
ASE-1	Transcription initiation complex	O15446	10849	CD3EAP	19q13.3	human	Y80	PHOSPHORYLATION	11382803	LAGKRHRyRVLSSCP	RNA_polI_A34	molecular association, regulation	transcription, induced; transcription, altered	CD3E(DISRUPTS)		10274620; 12482271	2	0	0	Y80 phosphorylation is associated with an initiation-competent  Pol1B complex.	
RGS2	GTPase activating protein, misc.	P41220	5997	RGS2	1q31	human	S64	PHOSPHORYLATION	10772901	KPKTGKKsKQQAFIK		activity, induced; intracellular localization				10296909	1	0	0	RGS2 phosphorylation increases G-alpha GTPase activity, and association with membrane fraction.  	
RENT1	C2H2-type zinc finger protein; EC 3.6.1.-; EC 3.6.4.-; Hydrolase	Q9EPU0	19704	Upf1		mouse	S1102	PHOSPHORYLATION	456314	SQIDVALsQDSTYQG		molecular association, regulation		STAU(INDUCES)		25347006	6	21	26	 increases Stau1-mediated decay of mRNA; regulates adipogenesis	
Lck	EC 2.7.10.2; KINASE; Kinase, protein; Protein kinase, TK; Protein kinase, tyrosine (non-receptor)	P06239	3932	LCK	1p34.3	human	Y394	PHOSPHORYLATION	447822	RLIEDNEyTAREGAK	Pkinase_Tyr	molecular association, regulation; intracellular localization; protein conformation; enzymatic activity, induced	cell growth, altered	Lck(INDUCES)		4914022; 3218; 27519611; 4042501; 15031330; 3303; 12662600	33	57	2953		
HPK1	EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, STE; Protein kinase, Ser/Thr (non-receptor)	P70218	26411	Map4k1		mouse	Y379	PHOSPHORYLATION	448160	LSDSDDDyDDVDIPA		molecular association, regulation; enzymatic activity, induced	transcription, altered	SLP76(INDUCES); BLNK(INDUCES)		6428; 1477	2	2	0		
CLOCK	ACETYLTRANSFERASE; Acetyltransferase; DNA binding protein; EC 2.3.1.48; Transcription factor	O15516	9575	CLOCK	4q12	human	S427	PHOSPHORYLATION	7911903	ALERFDHsPTPSASS		protein degradation	transcription, altered			12021324	2	2	1		
Axl	EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Protein kinase, TK; Protein kinase, tyrosine (receptor)	P30530	558	AXL	19q13.1	human	Y821	PHOSPHORYLATION	451491	QEPDEILyVNMDEGG		molecular association, regulation		PLCG1(INDUCES); PIK3R2(INDUCES); PIK3R1(INDUCES); Grb2(INDUCES)		3672	1	1	0		
MAP2 iso3	Cytoskeletal protein; Motility/polarity/chemotaxis	P15146-3	25595	Map2		rat	T259	PHOSPHORYLATION	450181	YSSRTPGtPGTPSYP			cytoskeletal reorganization			7325703	2	11	5	caused decrease in microtubule bundles	
REL	Transcription factor	Q04864	5966	REL	2p13-p12	human	S523	PHOSPHORYLATION	1980801	SMNLENPsCNSVLDP		activity, induced	transcription, induced			1975603	1	0	0	Double mutant S491A S494 is not responsive to NIK-induced activation of transcription at the IL-2 promoter.  The comparable site to S494 in mouse Rel is an alanine, so S491 may be the more important residue.	
H4	DNA binding protein	P62805	8359	HIST1H4A	6p22.1	human	K21	MONO-METHYLATION	1458623	GGAKRHRkVLRDNIQ		molecular association, regulation	cell cycle regulation	LUZP5(INDUCES); NCAPD3(INDUCES)		15022717	22	3	5		
NKCC1	Membrane protein, integral; Membrane protein, multi-pass; Transporter	P55012	20496	Slc12a2		mouse	T200	PHOSPHORYLATION	467236	YYDTHTNtYYLRTFG	AA_permease_N	activity, induced				17630301	5	0	0	Enzymatic activation by SLK3 requires two threonines separated by 4 amino acids. 	
RCAN1	Inhibitor protein	P53805	1827	RCAN1	21q22.12	human	S163	PHOSPHORYLATION	456022	PDKQFLIsPPASPPV	Calcipressin	activity, induced; protein degradation	transcription, altered			2413100; 6678	6	16	5	increases calcineurin-inhibiting activity of DSCR1; Phosphorylation of MCIP at S108/S112 by MEKK3 is required for activation of calcineurin/NFAT signaling. 	
PELI1	Adaptor/scaffold; EC 6.3.2.-; EC 6.3.2.19; Ligase; UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase	Q96FA3	57162	PELI1	2p13.3	human	S82	PHOSPHORYLATION	7388012	HSISYTLsRAQTVVV	Pellino	ubiquitination; enzymatic activity, induced				7228504	2	0	0		
ICK	EC 2.7.11.22; KINASE; Kinase, protein; Protein kinase, CMGC; Protein kinase, Ser/Thr (non-receptor)	Q9JKV2	56542	Ick		mouse	Y159	PHOSPHORYLATION	456052	SRPPYTDyVSTRWYR	Pkinase	enzymatic activity, induced				6637	1	17	440		
YAP1 iso2	Transcription, coactivator/corepressor	P46937-2	10413	YAP1	11q13	human	S381	PHOSPHORYLATION	3190672	TYHSRDEsTDSGLSM		protein degradation; ubiquitination; phosphorylation	cell growth, inhibited	BTRC(INDUCES)		7124733; 13320408	5	3	5		
Elf-1	DNA binding protein; Transcription factor	P32519	1997	ELF1	13q13	human	T231	PHOSPHORYLATION	4825111	CPKYIKWtQREKGIF	Ets		transcription, altered			4641408	1	1	0		
HOXB7	DNA binding protein; Motility/polarity/chemotaxis; Transcription factor	P09629	3217	HOXB7	17q21.3	human	S132	PHOSPHORYLATION	465569	RIYPWMRsSGTDRKR			cell differentiation, altered			8028	1	0	0		
AML3	DNA binding protein; Transcription factor	Q13950	860	RUNX2	6p21	human	S347	PHOSPHORYLATION	7386100	SDDDTATsDFCLWPS			transcription, altered			7324302	1	1	0		
BRCA1	EC 6.3.2.-; Nuclear receptor co-regulator; Transcription, coactivator/corepressor; Tumor suppressor; UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase	P38398	672	BRCA1	17q21	human	S1497	PHOSPHORYLATION	448730	EPGVERSsPSKCPSL		molecular association, regulation; intracellular localization		ATM(INDUCES)		1757; 9980402	5	3	2	promotes formation of BRCA1 foci	
PXN	Adaptor/scaffold; Cell adhesion; Cytoskeletal protein; Motility/polarity/chemotaxis	P49024	395832	PXN		chicken	S481	PHOSPHORYLATION	448767	FTPFINGsFFEHDGQ	LIM	intracellular localization	cell adhesion, altered			1936	1	0	0		
VHL	Tumor suppressor; UBIQUITIN LIGASE; Ubiquitin ligase	P40337	7428	VHL	3p25.3	human	S38	PHOSPHORYLATION	15573200	EESGAEEsGPEESGP		protein degradation	transcription, altered			15331032	1	0	0	regulates p53 activity and degradation of HIF1A	
p63	DNA binding protein; Transcription factor	Q9H3D4	8626	TP63	3q28	human	T491	PHOSPHORYLATION	4668106	PQQRNALtPTTIPDG		protein degradation				4659601; 7543532	3	1	0	DLX3-mediated degradation	
NKX3-1	DNA binding protein; Transcription factor	Q99801	4824	NKX3-1	8p21.2	human	S185	PHOSPHORYLATION	4825101	KTKRKQLsSELGDLE		protein degradation; ubiquitination				4641410	2	0	0		
MEK1	EC 2.7.12.2; KINASE; Kinase, protein; Protein kinase, STE; Protein kinase, dual-specificity	P31938	26395	Map2k1		mouse	T292	PHOSPHORYLATION	448287	ETPPRPRtPGRPLSS	Pkinase	molecular association, regulation	cell adhesion, altered; cell growth, altered	ERK2(INDUCES)		4914028	10	1	0		
DAB1	Adaptor/scaffold	Q8JH94	374083	DAB1		chicken	Y200	PHOSPHORYLATION	447960	VEDPVYQyIVFEAGH		phosphorylation	cytoskeletal reorganization			8417	4	0	0	increases Src activation and overall tyrosine phosphorylation levels in the cell, alters cellular morphology	
SHPS1	Cell adhesion; Cell surface; Membrane protein, integral; Motility/polarity/chemotaxis; Receptor, misc.	P78324	140885	SIRPA	20p13	human	Y470	PHOSPHORYLATION	451114	ASEDTLTyADLDMVH		phosphorylation				3205	5	7	26	Mutation of these 4 tyrosines does not affect JAK2 binding.  However, overexpression of the WT SHPS1 but not the 4 tyrosine to phenylalanine mutation reduces tyrosine phosphorylation of Jak2, STAT5B, and STAT3 and activation of Erk1/2 in response to growth hormone.  Does not affect STAT3 tyrosine phosphorylation in response to LIF agonist.	
CKAP4	Endoplasmic reticulum; Membrane protein, integral	Q07065	10970	CKAP4	12q23.3	human	S3	PHOSPHORYLATION	455353	_____MPsAKQRGSK			cytoskeletal reorganization			4595	3	0	0	Mutation of S3, S17 and S19 to glutamate leads to a collapse of the endoplasmic reticulum around the nucleus in interphase cells.	
SAMD4B	Unknown function	Q5PRF9	55095	SAMD4B	19q13.2	human	S642	PHOSPHORYLATION	21688100	SSVQRTHsLPVHSSP		molecular association, regulation		14-3-3 beta(INDUCES)		21683737	1	1	3	mutation of this site prevents 14-3-3 binding (pan-14-3-3 antibody)	
PLB	Inhibitor protein; Membrane protein, integral	P61014	18821	Pln		mouse	S16	PHOSPHORYLATION	448114	RSAIRRAsTIEMPQQ	Phospholamban; BatA	activity, induced				5121513	39	8	56	increase in calcium spark frequency and size	
NCoA2	Motility/polarity/chemotaxis; Transcription, coactivator/corepressor	Q15596	10499	NCOA2	8q13.3	human	S736	PHOSPHORYLATION	465446	TIKQEPVsPKKKENA			transcription, induced			8006	3	9	10	important for EGF-induced transcriptional activation	
CHOP	Autophagy; DNA binding protein; Transcription factor	P35638	1649	DDIT3	12q13.1-q13.2	human	S82	PHOSPHORYLATION	448091	STSQSPHsPDSSQSS	CDC45; Peptidase_S64; Macoilin; Phlebovirus_NSM; IncA; DUF3450; Atg14		transcription, altered			1027	1	1	0	CHOP-Gal-4 chimeric protein induced a reporter gene expression. 	
ATF-2	C2H2-type zinc finger protein; Transcription factor	P16951	11909	Atf2		mouse	T51	PHOSPHORYLATION	448224	SVIVADQtPTPTRFL			transcription, altered			2324	30	29	50		
SNCA	Adaptor/scaffold	P37840	6622	SNCA	4q21	human	S87	PHOSPHORYLATION	449948	KTVEGAGsIAAATGF	Synuclein		apoptosis, induced			8936	4	0	0	promotes intracellular SNCA inclusion formation and increases cell's cytotoxicity	
TIF1B	EC 6.3.2.-; KINASE; Kinase, protein; Ligase; Nuclear receptor co-regulator; Protein kinase, ATYPICAL; Protein kinase, atypical; Transcription, coactivator/corepressor; UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase	Q62318	21849	Trim28		mouse	S473	PHOSPHORYLATION	452391	SGMKRSRsGEGEVSG		molecular association, regulation; intracellular localization	cell cycle regulation; transcription, altered	CBX1(DISRUPTS)		3301211	8	62	20		
p21Cip1	Cell cycle regulation; Inhibitor protein	P38936	1026	CDKN1A	6p21.2	human	K161	UBIQUITINATION	9897003	KRRLIFSkRKP____		protein degradation; ubiquitination				5669	2	0	0	UV-induced 	
SNAP23	Vesicle protein	O70377	64630	Snap23		rat	S95	PHOSPHORYLATION	455262	NRTKNFEsGKNYKAT	SNAP-25		exocytosis, altered			15785207	5	2	1		
LKB1	Autophagy; EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, CAMK; Protein kinase, Ser/Thr (non-receptor)	Q15831	6794	STK11	19p13.3	human	T189	PHOSPHORYLATION	448149	LLLTTGGtLKISDLG	Pkinase		apoptosis, inhibited			1156	2	0	0		
ERK4	EC 2.7.11.24; KINASE; Kinase, protein; Protein kinase, CMGC; Protein kinase, Ser/Thr (non-receptor)	P31152	5596	MAPK4	18q21.1	human	S186	PHOSPHORYLATION	2228602	YSHKGYLsEGLVTKW	Pkinase	molecular association, regulation		MAPKAPK5(INDUCES)		2195704	2	8	2	                                                                                                                                                                                        	
LAT	Adaptor/scaffold; Membrane protein, integral	O43561	27040	LAT	16p11.2	human	Y220	PHOSPHORYLATION	448005	SLDGSREyVNVSQEL		activity, induced; molecular association, regulation	cytoskeletal reorganization; transcription, induced; transcription, altered	SLP76(INDUCES); PLCG1(INDUCES); GADS(INDUCES); Grb2(INDUCES)		8611; 5955628; 14987302	22	2	38	NF-AT mediated transcription; Does not regulate integrin mediated adhesion.; association of LAT-rich vesicles with surface clusters of  SLP76	
PPP1R16B	Motility/polarity/chemotaxis; Protein phosphatase, regulatory subunit	Q95N27	282091	PPP1R16B		cow	S333	PHOSPHORYLATION	486244	LRHKSSLsRRTSSAG			cytoskeletal reorganization			12058	1	1	0		
NMDAR1	Channel, calcium; Channel, ligand-gated; Membrane protein, integral; Membrane protein, multi-pass	P35439	24408	Grin1		rat	S890	PHOSPHORYLATION	447737	ITSTLASsFKRRRSS		molecular association, regulation; intracellular localization; activity, inhibited		calmodulin(DISRUPTS)		1706; 723; 17675052	12	3	3	phosphomimetic mutations increased sensitivity to inhibition by ethanol	
SLC3A2	Membrane protein, integral; Transporter	P08195	6520	SLC3A2	11q13	human	S531	PHOSPHORYLATION	6003501	RRLSDQRsKERSLLH	DUF3459		cell adhesion, altered			5930022	1	0	0	enhances cell- cell interactions	
MOR-1	GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR	P33535	25601	Oprm1		rat	S375	PHOSPHORYLATION	447784	QNTREHPsTANTVDR		molecular association, regulation; receptor desensitization, altered; receptor internalization, altered; protein conformation		ARR3(INDUCES); ARRB2(INDUCES)		5782; 2927; 1182; 27132404; 2807232; 4756	16	2	0		
USP10	EC 3.1.2.15; EC 3.4.19.12; Protease; Ubiquitin conjugating system; Ubiquitin-specific protease	Q14694	9100	USP10	16q24.1	human	S337	PHOSPHORYLATION	12483200	ASGTLPVsQPKSWAS		protein stabilization; ubiquitination; intracellular localization	carcinogenesis, inhibited; cell growth, altered			13354740	1	0	0	regulates p53 homeostasis	
calponin 1	Actin binding protein; Contractile protein; Motility/polarity/chemotaxis; Myosin binding protein	P26932	396522	CNN1		chicken	T180	PHOSPHORYLATION	469594	FASQQGMtAYGTRRH	Calponin	molecular association, regulation		ACTA1(DISRUPTS)		8316	1	0	1	f-actin (rabbit skeletal muscle) shown by co-sedimentation	
GSK3A	EC 2.7.11.1; EC 2.7.11.26; KINASE; Kinase, protein; Protein kinase, CMGC; Protein kinase, Ser/Thr (non-receptor)	P49840	2931	GSK3A	19q13.2	human	S21	PHOSPHORYLATION	448584	SGRARTSsFAEPGGG		enzymatic activity, inhibited				3537; 6438; 687; 6011119	122	11	274		
PDE5A	EC 3.1.4.17; EC 3.1.4.35; Nucleotide Metabolism - purine; Phosphodiesterase	O76074	8654	PDE5A	4q27	human	S102	PHOSPHORYLATION	448178	GTPTRKIsASEFDRP		molecular association, regulation; enzymatic activity, induced			Other(INDUCES)	2466209	6	2	0	increases cGMP (allosteric regulator) affinity by decreasing Kd. no enzymatic activation without cGMP present.	
CBX3	DNA binding protein	Q13185	11335	CBX3	7p15.2	human	S93	PHOSPHORYLATION	457001	KDGTKRKsLSDSESD		molecular association, regulation; intracellular localization		Ku70(NOT_REPORTED)		2659800; 7735	2	26	52		
rhodopsin	GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR	P15409	212541	Rho		mouse	S338	PHOSPHORYLATION	448679	DDASATAsKTETSQV	LRR_6	receptor inactivation, altered				8780	6	5	0	Mutant rhodopsins had prolonged rate of recovery with increasing number of phosphorylation sites. 	
DEK	DNA binding protein; DNA replication; Histone-binding protein; RNA splicing	P35659	7913	DEK	6p22.3	human	S32	PHOSPHORYLATION	465616	MPGPREEsEEEEDED		molecular association, regulation	RNA splicing, altered	U2AF1(INDUCES)		8094	2	30	33		
rhodopsin	GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR	P15409	212541	Rho		mouse	S334	PHOSPHORYLATION	448677	PLGDDDAsATASKTE	LRR_6	receptor inactivation, altered				8780	7	5	0	Mutant rhodopsins had prolonged rate of recovery with increasing number of phosphorylation sites. 	
SP1	C2H2-type zinc finger protein; DNA binding protein; Transcription factor	P08047	6667	SP1	12q13.1	human	S728	PHOSPHORYLATION	2535904	VGTLPLDsGAGSEGS		protein degradation				2425224	2	0	0		
SynGAP	GTPase activating protein, Ras	Q9QUH6	192117	Syngap1		rat	S780	PHOSPHORYLATION	451015	MARGLNSsMDMARLP	DUF3498	activity, induced				3266	1	5	0		
TACE	EC 3.4.24.86; Membrane protein, integral; Motility/polarity/chemotaxis; Protease	P78536	6868	ADAM17	2p25	human	S819	PHOSPHORYLATION	449039	QRQNRVDsKETEC__		enzymatic activity, induced				12778825	2	1	1		
IRF5	DNA binding protein; Transcription factor	Q13568	3663	IRF5	7q32	human	S446	PHOSPHORYLATION	26389901	DSIRLQIsNPDLKDR		protein stabilization; molecular association, regulation; intracellular localization	apoptosis, induced; transcription, induced	CBP(INDUCES)		25779418; 25785429	2	1	0		
CDK5R1	Protein kinase, regulatory subunit	P61809	12569	Cdk5r1		mouse	S33	PHOSPHORYLATION	13421403	HYTAVQNsKNAKDKN	CDK5_activator	protein processing				13358804	1	0	0	calpain-mediated cleavage	
SRC-3	ACETYLTRANSFERASE; Acetyltransferase; EC 2.3.1.48; Motility/polarity/chemotaxis; Nuclear receptor co-regulator; Transcription, coactivator/corepressor	Q9Y6Q9	8202	NCOA3	20q12	human	S1062	PHOSPHORYLATION	4252805	DQLHTLLsNTDATGL	Nuc_rec_co-act	protein stabilization; molecular association, regulation		PSMA3(DISRUPTS)		4248206	1	0	1	some subset of these 8 residues	
ERK5	EC 2.7.11.24; KINASE; Kinase, protein; Protein kinase, CMGC; Protein kinase, Ser/Thr (non-receptor)	Q9WVS8	23939	Mapk7		mouse	T723	PHOSPHORYLATION	455520	LPPVFSGtPKGSGAG			transcription, altered			14551427	3	7	1		
Bcl-2	Apoptosis; Autophagy; Membrane protein, integral	P10415	596	BCL2	18q21.3	human	S87	PHOSPHORYLATION	448396	AAAGPALsPVPPVVH		protein stabilization; molecular association, regulation; ubiquitination; activity, inhibited	apoptosis, altered; apoptosis, induced; apoptosis, inhibited	beclin 1(DISRUPTS); Bax(INDUCES); p53(DISRUPTS)		2653909; 5288; 6431; 469; 4647112; 4313608; 7613744; 2365401; 2403300; 1830; 4647110; 6331303	17	0	0	phosphorylation induced by viral infection	
Rb-like 1	Transcription, coactivator/corepressor; Tumor suppressor	P28749	5933	RBL1	20q11.2	human	S640	PHOSPHORYLATION	451296	RRDMQPLsPISVHER			cell growth, altered			3519	2	8	9		
ITGB7	Cell adhesion; Membrane protein, integral; Motility/polarity/chemotaxis; Receptor, misc.	P26010	3695	ITGB7	12q13.13	human	T784	PHOSPHORYLATION	464648	LYKSAITtTINPRFQ	Integrin_b_cyt	molecular association, regulation		FLNA(DISRUPTS)		7907	1	0	0	based on glutamate mutant of threonine site	
eEF2K	EC 2.7.11.20; KINASE; Kinase, protein; Protein kinase, ATYPICAL; Protein kinase, Ser/Thr (non-receptor); Translation	P70531	25435	Eef2k		rat	S499	PHOSPHORYLATION	455998	RLHLPRPsAVALEVQ		enzymatic activity, induced				6523	2	3	2		
NFAT3	DNA binding protein; Transcription factor	Q14934	4776	NFATC4	14q11.2	human	S676	PHOSPHORYLATION	455348	SNGRRKRsPTQSFRF	TIG	activity, induced	transcription, induced			4577	2	0	0		
GTF2F1	EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, Ser/Thr (non-receptor); Transcription initiation complex	P35269	2962	GTF2F1	19p13.3	human	T389	PHOSPHORYLATION	483595	RGNSRPGtPSAEGGS	TFIIF_alpha	activity, inhibited	transcription, inhibited			2852646	1	22	223	slows down RNA pol II elongation	
GRB7	Adaptor/scaffold; Motility/polarity/chemotaxis	Q14451	2886	GRB7	17q12	human	Y338	PHOSPHORYLATION	7965101	AAFRLFKyGVQLYKN		phosphorylation	cell cycle regulation; cell motility, altered			7889921	1	0	0	; double mutation Grb7 Y188, 338F inhibits phosphorylation of FAK Y397 (Y428 in mouse), Y861 (Y899 in mouse) and PXN Y118; 
involed in tumorigenesis process	
desmin	Cytoskeletal protein; Motility/polarity/chemotaxis	P31001	13346	Des		mouse	S8	PHOSPHORYLATION	478271	MSQAYSSsQRVSSYR			transcription, altered; cell growth, altered			9579	1	0	0	important for cardiomyogenesis	
STAT5A	DNA binding protein; Motility/polarity/chemotaxis; Transcription factor	P42230	20850	Stat5a		mouse	S725	PHOSPHORYLATION	448749	TYMDQAPsPVVCPQP		activity, induced; molecular association, regulation; activity, inhibited; phosphorylation	carcinogenesis, altered		DNA(DISRUPTS)	2019; 14551412; 5415; 1906	13	1	0		
vinculin iso2	Cell adhesion; Cytoskeletal protein; Motility/polarity/chemotaxis	P18206-2	7414	VCL	10q22.2	human	Y1065	PHOSPHORYLATION	454003	WVRKTPWyQ______	Vinculin	activity, induced	cytoskeletal reorganization			15278820	6	1	20		
CDH1	Cell adhesion; Membrane protein, integral; Motility/polarity/chemotaxis; UBIQUITIN LIGASE; Ubiquitin ligase	P09803	12550	Cdh1		mouse	Y756	PHOSPHORYLATION	456025	DTRDNVYyYDEEGGG	Cadherin_C	molecular association, regulation		CBLL1(INDUCES)		6565	2	2	41		
LRP2	Membrane protein, integral; Motility/polarity/chemotaxis; Receptor, misc.	P98164	4036	LRP2	2q31.1	human	T4478	PHOSPHORYLATION	767906	SENGNGVtFRSGADL		receptor internalization, altered; receptor recycling, altered				762703	1	0	0		
CIITA	DNA binding protein; Transcription, coactivator/corepressor	P33076	4261	CIITA	16p13	human	S286	PHOSPHORYLATION	2902204	TSPDRPGsTSPFAPS		intracellular localization	transcription, altered			8373	1	0	0		
NFkB-p105	DNA binding protein; Transcription factor	P19838	4790	NFKB1	4q24	human	S927	PHOSPHORYLATION	447770	DSDSVCDsGVETSFR		protein degradation; ubiquitination; protein processing				1192; 1189; 7550831; 1191; 2611; 1190	6	0	2	S927A mutant can be ubiquinated and processed to p50 in vitro, but in a constitutive basal process. 	
NUP98 iso2	Motility/polarity/chemotaxis; Nucleoporin	P52948-2	4928	NUP98	11p15.5	human	S664	PHOSPHORYLATION	14577176	AGNKHSNsNSVDDTI		intracellular localization				18331300	1	8	0	as multiple sites (13PM) mutant 	
VASP	Cytoskeletal protein; Motility/polarity/chemotaxis	P50552	7408	VASP	19q13.32	human	S239	PHOSPHORYLATION	448380	GAKLRKVsKQEEASG		intracellular localization	cell motility, altered; cell adhesion, altered; cytoskeletal reorganization; transcription, inhibited; cell growth, altered			5955624; 13270525; 5358615; 3413; 3391006; 15571604	41	13	3	 S238 phosphorylation inhibits growth.; Phosphorylation disrupts colocalization with F-actin.    ; Phosphorylation at S156 is stimulates growth; reduces the number of HSV-1 infected cells; H. pylori-induced cell elongation	
osteopontin	Secreted; Secreted, signal peptide	P10451	6696	SPP1	4q22.1	human	S123	PHOSPHORYLATION	455738	DSHQSDEsHHSDESD	Osteopontin	molecular association, regulation; activity, inhibited			Other(INDUCES)	10425106	1	4	0	peptide with phosphorylated S117, S120, S123, S126 and S129 has increased binding to hydroxyapatite, and inhibits bone mineralization in vivo and in vitro 	
p53	Activator protein; DNA binding protein; Motility/polarity/chemotaxis; Nuclear receptor co-regulator; Transcription factor; Tumor suppressor	P02340	22059	Tp53		mouse	K380	UBIQUITINATION	464662	RHKKTMVkKVGPDSD			transcription, altered			3141407	9	0	1	p53K6R (K378/383/369/379/367/370/R) mutant is still ubiquitinated and shows normal stability of p53 before and after DNA damage	
DNAPK	DNA repair; EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, ATYPICAL; Protein kinase, Ser/Thr (non-receptor)	P78527	5591	PRKDC	8q11	human	T2609	PHOSPHORYLATION	448710	LTPMFVEtQASQGTL		intracellular localization; enzymatic activity, induced	chromatin organization, altered; cell growth, altered			14821613; 7613717; 4862622; 9570	17	3	8	increases survival in ionizing radiation and repairing double strand DNA breaks; T2609 required for telomeric end capping function; T2609 phosphorylation is required for double-strand break repair.; T68-P Chk2 localizes at the centrosomes and midbody, and T2609-P DNA-PK at midbody during mitosis	
SLC4A4	Membrane protein, integral; Membrane protein, multi-pass; Transporter	Q9Y6R1	8671	SLC4A4	4q21	human	S65	PHOSPHORYLATION	4699735	ERISENYsDKSDIEN		intracellular localization				27619344	1	11	0	 reduction of surface expression; inhibition by STLK3	
CRMP-1	Cell development/differentiation; Cytoskeletal protein; Hydrolase	Q14194	1400	CRMP1	4p16.1	human	T101	PHOSPHORYLATION	11539300	RAALVGGtTMIIDHV	Amidohydro_1		cell cycle regulation			11484413	1	1	0		
HMGN1	DNA binding protein	P05114	3150	HMGN1	21q22.2	human	S21	PHOSPHORYLATION	454111	KEEPKRRsARLSAKP	HMG14_17	molecular association, regulation; intracellular localization		14-3-3 zeta(INDUCES)		8551; 5441	4	3	14	Phosphorylation facilitates localization to non-nuclear pools.	
CAD	Amino Acid Metabolism - alanine, aspartate and glutamate; EC 2.1.3.2; EC 3.5.2.3; EC 6.3.5.5; Hydrolase; KINASE; Ligase; Nucleotide Metabolism - pyrimidine; Transferase	P08955	101843763	Cad		hamster	T1037	PHOSPHORYLATION	2861417	QQCRVLGtSPEAIDS	CPSase_L_chain	enzymatic activity, induced				2852662	1	0	0		
SPT5	Transcription, coactivator/corepressor	O00267	6829	SUPT5H	19q13	human	T814	PHOSPHORYLATION	458820	PLHDGSRtPAQSGAW	CTD		transcription, altered			7460	1	0	2	required for c-fos induction and activation in vivo	
NDRG1	Cell development/differentiation; Vesicle protein	Q92597	10397	NDRG1	8q24.3	human	T346	PHOSPHORYLATION	454245	GTRSRSHtSEGTRSR		phosphorylation	carcinogenesis, inhibited; carcinogenesis, altered			21683752; 14081211	12	6	237		
tau iso3	Cytoskeletal protein	P10636-3	4137	MAPT	17q21.1	human	S105	PHOSPHORYLATION	447927	GDRSGYSsPGSPGTP		molecular association, regulation	cytoskeletal reorganization			5955602	57	17	33	regulates association with membrane	
5-HT(2A)	GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR	P14842	29595	Htr2a		rat	S314	PHOSPHORYLATION	6057801	AGRRTMQsISNEQKA	7tm_1; DUF1385	receptor desensitization, altered; activity, inhibited				5930042	1	0	0		
MyoD	DNA binding protein; RNA splicing; Transcription factor	P10085	17927	Myod1		mouse	S237	PHOSPHORYLATION	3188104	YSEAAREsRPGKSAA	Myf5	activity, induced	transcription, altered			8660	1	0	0		
MUC1	Actin binding protein; Cell adhesion; Membrane protein, integral; Motility/polarity/chemotaxis; Nuclear receptor co-regulator	P15941	4582	MUC1	1q21	human	Y1243	PHOSPHORYLATION	454879	NGGSSLSyTNPAVAA		molecular association, regulation; receptor internalization, altered		Grb2(INDUCES)		4364	3	4	79	Y1203 and Y1243 are both required for efficient mucin 1 endocytosis	
Daxx	Apoptosis; Nuclear receptor co-regulator; Transcription, coactivator/corepressor	Q9UER7	1616	DAXX	6p21.3	human	S176	PHOSPHORYLATION	3214944	TNAENTAsQSPRTRG	Daxx	protein stabilization	apoptosis, induced			10353935	2	0	0	required for TNF alpha -dependent accumulation of Daxx in cells 	
SF1	RNA binding protein; RNA splicing; Spliceosome; Transcription, coactivator/corepressor	Q15637-2	7536	SF1	11q13	human	S80	PHOSPHORYLATION	452434	PPNPEDRsPSPEPIY		molecular association, regulation	RNA splicing, altered	U2AF2(INDUCES)		8058	1	45	12	facilitates formation of the SF1-U2AF-RNA complex	
ID2	DNA binding protein; Transcription, coactivator/corepressor	P41136	15902	Id2		mouse	S5	PHOSPHORYLATION	451265	___MKAFsPVRSVRK		intracellular localization	cell cycle regulation; apoptosis, altered; cell growth, altered			9938510	2	1	0	Phosphorylated Id2 is localized to the nucleus.	
XRCC1	DNA repair	P18887	7515	XRCC1	19q13.2	human	T488	PHOSPHORYLATION	451452	GAEDSGDtEDELRRV		molecular association, regulation; intracellular localization		Pnk1(INDUCES)		3651	2	9	0	regulates rapid repair of cellular DNA single-strand breaks	
SMPD3	EC 3.1.4.12; Lipid Metabolism - sphingolipid; Membrane protein, integral; Phospholipase	Q9JJY3	58994	Smpd3		mouse	S299	PHOSPHORYLATION	9430287	SPSASREsLVKARAG		protein stabilization; enzymatic activity, induced				22463914	1	3	4		
RIP140	Nuclear receptor co-regulator; Transcription, coactivator/corepressor	Q8CBD1	268903	Nrip1		mouse	S1003	PHOSPHORYLATION	455634	VTDHRTFsYPGMVKT		molecular association, regulation; methylation; intracellular localization	transcription, altered	14-3-3 beta(INDUCES); PRMT1(INDUCES)		3301209	2	2	0	regulates fat accumulation	
LRP6	Membrane protein, integral; Receptor, misc.	O75581	4040	LRP6	12p13.2	human	T1548	PHOSPHORYLATION	21009100	YAPSRRMtSVATAKG		molecular association, regulation; intracellular localization		G-alpha-s(INDUCES)		20834129	1	0	0	Mutation of T1548 impairs G-alpha-s to the plasma membrane. 	
HNF4 alpha	DNA binding protein; Nuclear receptor; Transcription factor	P22449	25735	Hnf4a		rat	S87	PHOSPHORYLATION	478421	CKGFFRRsVRKNHMY	zf-C4; Foamy_virus_ENV	protein degradation; intracellular localization	transcription, altered		DNA(DISRUPTS)	9584	1	0	0	S87D mutation impairs nuclear localization.	
IRS1	Adaptor/scaffold; Motility/polarity/chemotaxis	P35569	16367	Irs1		mouse	S662	PHOSPHORYLATION	2352501	PNGYMMMsPSGSCSP		molecular association, regulation		PIK3C2A(DISRUPTS)		4032	1	1	6		
IRAK1	EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, Ser/Thr (non-receptor); Protein kinase, TKL	P51617	3654	IRAK1	Xq28	human	T387	PHOSPHORYLATION	447721	RTQTVRGtLAYLPEE	Pkinase	enzymatic activity, induced				3220	3	0	0		
ROMK	Channel, potassium; Membrane protein, integral; Membrane protein, multi-pass	P48048	3758	KCNJ1	11q24	human	S44	PHOSPHORYLATION	449605	RQRARLVsKDGRCNI	IRK	protein processing; activity, inhibited				8785; 2807231	8	0	0		
C/EBP-alpha	DNA binding protein; Transcription factor	P05554	24252	Cebpa		rat	S248	PHOSPHORYLATION	449826	GLPGPGGsLKGLAGP		activity, induced	cell differentiation, altered; cell growth, altered			2195475; 2371	2	0	0	S248A mutation reduces cells differentiation	
TRPV4	Channel, cation; Membrane protein, integral; Membrane protein, multi-pass	Q9HBA0	59341	TRPV4	12q24.1	human	S162	PHOSPHORYLATION	10272403	FDIVSRGsTADLDGL		activity, induced				9980421	1	0	0		
SKP2	Ubiquitin conjugating system	Q13309	6502	SKP2	5p13	human	S72	PHOSPHORYLATION	480507	PPRKRLKsKGSDKDF		protein stabilization; phosphorylation	cell cycle regulation			15022729	3	2	5		
Ret	EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Protein kinase, TK; Protein kinase, tyrosine (receptor)	P07949	5979	RET	10q11.2	human	Y928	PHOSPHORYLATION	3078002	ESLFDHIyTTQSDVW	Pkinase_Tyr	enzymatic activity, induced				8770	1	1	0		
Akt1	EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor)	P31749	207	AKT1	14q32.32	human	T72	PHOSPHORYLATION	460648	TERPRPNtFIIRCLQ	PH	enzymatic activity, induced	apoptosis, inhibited			7752	1	0	0	doxorubicin-induced apoptosis	
N-WASP	Adaptor/scaffold; Motility/polarity/chemotaxis	O08816	682507	Wasl		rat	T202	PHOSPHORYLATION	23003803	LTKADIGtPSNFQHI	PBD	molecular association, regulation; protein conformation	cytoskeletal reorganization			22958935	1	0	0	 inhibits actin polymerization in vitro; inhibits the filopodia promoting activity of N-WASP	
GIRK1	Channel, potassium; Membrane protein, integral; Membrane protein, multi-pass	NP_113798	50599	Kcnj3		rat	Y12	PHOSPHORYLATION	457610	RRKFGDDyQVVTTSS		activity, inhibited				8596	4	0	0		
Borealin	Cell cycle regulation	Q53HL2	55143	CDCA8	1p34.3	human	T94	PHOSPHORYLATION	4203201	ATADLDItEINKLTA			cell cycle regulation; cytoskeletal reorganization			4201803	2	0	0	chromosome alignment in mitosis	
TSC2	Cell cycle regulation; GTPase activating protein, misc.; Nuclear receptor co-regulator; Tumor suppressor	P49815	7249	TSC2	16p13.3	human	T1462	PHOSPHORYLATION	448546	GLRPRGYtISDSAPS		activity, inhibited; phosphorylation	apoptosis, inhibited; transcription, altered			4158; 2362505	41	5	43		
GLI3	C2H2-type zinc finger protein; Transcription factor	P10071	2737	GLI3	7p13	human	S1006	PHOSPHORYLATION	15501397	GHGVRRAsDPVRTGS		protein processing	transcription, inhibited			25779400	1	2	2		
PDE10A iso2	EC 3.1.4.17; EC 3.1.4.35; Nucleotide Metabolism - purine; Phosphodiesterase	Q9Y233-2	10846	PDE10A	6q26	human	C11	PALMITOYLATION	15169800	GPSNNAScFRRLTEC		intracellular localization				15026107	1	0	0		
FOXO1A	DNA binding protein; Nuclear receptor co-regulator; Transcription factor	Q12778	2308	FOXO1	13q14.1	human	S394	PHOSPHORYLATION	12607401	LTVSTQSsPGTMMQQ		intracellular localization	transcription, altered			12525214	1	0	0	multiple site mutant (8A)	
KCNMB4	Channel, potassium; Membrane protein, integral; Membrane protein, multi-pass	Q86W47	27345	KCNMB4	12q	human	T11	PHOSPHORYLATION	451271	LRVAYEYtEAEDKSI	CaKB	activity, inhibited				3490	1	0	0	regulates slowpoke K(+) channel kinetics	
MYPT1	Motility/polarity/chemotaxis; Protein phosphatase, regulatory subunit	Q9DBR7	17931	Ppp1r12a		mouse	T694	PHOSPHORYLATION	448587	ARQSRRStQGVTLTD		enzymatic activity, inhibited				1186	49	15	213		
PACS-1	Adaptor/scaffold	Q6VY07	55690	PACS1	11q13.1-q13.2	human	S278	PHOSPHORYLATION	2911721	SPDIDNYsEEEEESF		activity, induced; molecular association, regulation		TXN(DISRUPTS)		8714	1	0	0	increases binding to HIV Nef protein	
claudin 4	Cytoskeletal protein; Membrane protein, integral; Membrane protein, multi-pass	O14493	1364	CLDN4	7q11.23	human	S194	PHOSPHORYLATION	4199301	PRTDKPYsAKYSAAR	IncA	intracellular localization	cytoskeletal reorganization			4049503	1	0	1		
POU4F1	Cell development/differentiation; DNA binding protein; Transcription factor	Q01851	5457	POU4F1	13q31.1	human	S121	PHOSPHORYLATION	6322100	GDLLDHIsSPSLALM		activity, induced	cell differentiation, induced; transcription, induced			6320801	1	0	0		
Cdc25C	EC 3.1.3.48; Motility/polarity/chemotaxis; PHOSPHATASE; Protein phosphatase, dual-specificity	P30307	995	CDC25C	5q31	human	S263	PHOSPHORYLATION	486328	LCLKKTVsLCDITIT	M-inducer_phosp	intracellular localization				12099	1	3	3	negatively regulates translocation from cytoplasm to nucleus	
PLM	Cell surface; Channel, misc.; Membrane protein, integral	Q9Z239	56188	Fxyd1		mouse	S83	PHOSPHORYLATION	451424	EEGTFRSsIRRLSSR	IncA	intracellular localization				2610203	18	13	60	After stimulation with phorbol ester.	
Fos	DNA binding protein; Motility/polarity/chemotaxis; Transcription factor	P01100	2353	FOS	14q24.3	human	S32	PHOSPHORYLATION	470080	DSLSYYHsPADSFSS		protein stabilization; molecular association, regulation		UBR1(DISRUPTS)		8961	1	0	0		
LRP1	Cell surface; Membrane protein, integral; Motility/polarity/chemotaxis; Receptor, misc.	Q07954	4035	LRP1	12q13.3	human	S4520	PHOSPHORYLATION	450168	GGHGSRHsLASTDEK		molecular association, regulation; receptor desensitization, altered; receptor internalization, altered		Shc1(INDUCES); GULP1(INDUCES); DAB1(INDUCES)		2786; 12482284	2	11	0		
DAB1	Adaptor/scaffold	P97318	13131	Dab1		mouse	Y198	PHOSPHORYLATION	447629	EDVEDPVyQYIVFEA		intracellular localization	cell motility, altered; cytoskeletal reorganization			6498; 10425111	10	1	0		
PCAF	ACETYLTRANSFERASE; Acetyltransferase; EC 2.3.1.48; Nuclear receptor co-regulator	Q92831	8850	KAT2B	3p24	human	K428	ACETYLATION	458985	LEANPGEkRKMTDSH		enzymatic activity, induced				7551	1	0	0	in vitro	
ZAP	RNA binding protein; Transferase	Q8K3Y6	252832	Zc3hav1		rat	S262	PHOSPHORYLATION	14583026	HNSLEFLsPVVSPLG		activity, induced				25227647	1	0	0		
ILK	EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, Ser/Thr (non-receptor); Protein kinase, TKL	Q13418	3611	ILK	11p15.4	human	S246	PHOSPHORYLATION	479407	CPRLRIFsHPNVLPV	Pkinase_Tyr	intracellular localization	cell motility, altered			9405	1	0	0		
RhoA	G protein; G protein, monomeric, Rho; Motility/polarity/chemotaxis	P61586	387	RHOA	3p21.3	human	S188	PHOSPHORYLATION	449035	ARRGKKKsGCLVL__		protein stabilization; molecular association, regulation; intracellular localization; activity, inhibited	cell motility, induced; cytoskeletal reorganization	diaphanous 1(INDUCES); PKN1(INDUCES); RhoGDI alpha(INDUCES); ROCK1(DISRUPTS)		6459; 17630403; 6908; 6302; 2066; 21588902	9	0	0	propagation of protrusions	
LRP1	Cell surface; Membrane protein, integral; Motility/polarity/chemotaxis; Receptor, misc.	G3V928	299858	Lrp1		rat	Y4508	PHOSPHORYLATION	451245	TNFTNPVyATLYMGG		molecular association, regulation		CSK(INDUCES); PLCG1(INDUCES); SNX17(DISRUPTS); SHP-2(INDUCES); 14-3-3 gamma(DISRUPTS); PIK3R1(INDUCES); Grb2(INDUCES)		10425107	5	2	0		
TLE1	Transcription, coactivator/corepressor	Q04724	7088	TLE1	9q21.32	human	S239	PHOSPHORYLATION	454385	KDSSHYDsDGDKSDD		activity, induced	transcription, altered; cell growth, altered			4251	2	2	1		
SSH1	EC 3.1.3.16; EC 3.1.3.48; PHOSPHATASE; Protein phosphatase, dual-specificity	Q8WYL5	54434	SSH1	12q24.11	human	S978	PHOSPHORYLATION	455275	SPLKRSHsLAKLGSL		molecular association, regulation; intracellular localization; activity, inhibited; phosphorylation	cell motility, altered	14-3-3 beta(INDUCES); 14-3-3 zeta(INDUCES)		18837516; 9160402; 7313804; 4499	6	0	0		
TDP43	RNA binding protein	Q13148	23435	TARDBP	1p36.22	human	S410	PHOSPHORYLATION	3084601	SSMDSKSsGWGM___		molecular association, regulation; intracellular localization	autophagy, altered	TDP43(DISRUPTS)		17675062; 8164809; 6331344	18	0	0	accumulates in insoluble cytoplasmic aggregates; phosphomimetic S410/409D mutant reduces TARDBP aggregation and autophagy; found in inclusion bodies	
KCC2	Membrane protein, integral; Membrane protein, multi-pass; Transporter	Q63633	171373	Slc12a5		rat	S963	PHOSPHORYLATION	487533	ITDESRGsIRRKNPA		protein stabilization				12265	4	4	2		
ASK1	EC 2.7.11.25; KINASE; Kinase, protein; Protein kinase, STE; Protein kinase, Ser/Thr (non-receptor)	Q99683	4217	MAP3K5	6q22.33	human	S83	PHOSPHORYLATION	447735	ATRGRGSsVGGGSRR		enzymatic activity, inhibited; phosphorylation	apoptosis, altered; apoptosis, inhibited; transcription, altered			456; 12725504; 6115915; 1976303; 4505; 5278; 6661	15	0	0		
coilin	Oxidoreductase	P38432	8161	COIL	17q22	human	S202	PHOSPHORYLATION	10336301	KKAKNPKsPKVQAVK		intracellular localization				10167115	1	0	0	S202A mutant is localized to nucloplasmic coiled bodies, while S202D is localized to intranucleolar domains. Phosphorylation may regulate SnRNP-nucleolar interactions.	
BAD	Apoptosis	Q92934	572	BAD	11q13.1	human	S75	PHOSPHORYLATION	447860	EIRSRHSsYPAGTED	Bcl-2_BAD	activity, induced; molecular association, regulation; activity, inhibited	apoptosis, altered; apoptosis, inhibited; cell adhesion, altered; transcription, altered; cell growth, altered	14-3-3 beta(INDUCES); Bcl-2(DISRUPTS); Bcl-xL(DISRUPTS)		4647108; 4214815; 7644601; 6756; 21697400; 7237; 6115915; 4646625; 5286; 22463919; 4646621; 15031308; 7309808; 4646618; 20744401; 4457; 5285	113	9	164	S75 phosphorylation is required for inhibition of LY294002 induced apoptosis, by R1881.	
Src	EC 2.7.10.2; KINASE; Kinase, protein; Protein kinase, TK; Protein kinase, tyrosine (non-receptor)	P00523	396442	SRC		chicken	S12	PHOSPHORYLATION	448230	KSKPKDPsQRRRSLE		molecular association, regulation; phosphorylation	cell growth, altered	PKCD(DISRUPTS)		1278; 1277	5	0	0	Mutation of S16 increases phosphorylation at S12	
Fascin	Actin binding protein; Cytoskeletal protein; Motility/polarity/chemotaxis	Q61553	14086	Fscn1		mouse	S39	PHOSPHORYLATION	450888	KVNASASsLKKKQIW	Fascin	molecular association, regulation; intracellular localization	cytoskeletal reorganization	ACTA1(DISRUPTS); ACTB(DISRUPTS)		2865424; 3179	8	5	0		
SSBP3	Cell cycle regulation; DNA binding protein; Transcription regulation	Q9BWW4	23648	SSBP3	1p32.3	human	Y25	PHOSPHORYLATION	1806901	EKLALYVyEYLLHVG		activity, induced; intracellular localization	transcription, induced			1713132	1	0	0		
LRP6	Membrane protein, integral; Receptor, misc.	O75581	4040	LRP6	12p13.2	human	S1420	PHOSPHORYLATION	460717	YVVHGPAsVPLGYVP		molecular association, regulation		axin 1(DISRUPTS)		7726	1	0	0		
RACK1	Adaptor/scaffold; G protein; G protein, heterotrimeric; G protein, heterotrimeric beta WD; Motility/polarity/chemotaxis; Nuclear receptor co-regulator	P63244	10399	GNB2L1	5q35.3	human	Y302	PHOSPHORYLATION	2850000	GQTLFAGyTDNLVRV	WD40	molecular association, regulation	cell motility, altered; cell growth, altered	PPP2CA(INDUCES); ITGB1(INDUCES)		2831752	1	0	0	phosphorylation of this site stimulates binding of RACK1 to PPP2CA, whereas does not affect its binding to ITGB1	
SLC3A2	Membrane protein, integral; Transporter	P08195	6520	SLC3A2	11q13	human	S408	PHOSPHORYLATION	6003503	TSSYLSDsGSTGEHT			cell adhesion, altered			5930022	1	0	0	enhances cell- cell interactions	
geminin	Cell cycle regulation; Motility/polarity/chemotaxis	O75496	51053	GMNN	6p22.3	human	T203	PHOSPHORYLATION	475945	EGTVSSStDAKPCI_	Fmp27_WPPW		apoptosis, altered			9237	1	0	0	regulates geminin cleavage by caspase-3	
IGF1R	EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Protein kinase, TK; Protein kinase, tyrosine (receptor)	P08069	3480	IGF1R	15q26.3	human	Y980	PHOSPHORYLATION	448390	YASVNPEyFSAADVY		activity, induced; phosphorylation	cell cycle regulation; apoptosis, altered; cell differentiation, altered; cell growth, altered			2727; 2703; 2726	6	0	1	ERK phosphorylation	
Srcasm	Adaptor/scaffold	O75674	10040	TOM1L1	17q23.2	human	Y392	PHOSPHORYLATION	451208	NLTSSHAyDNFLEHS		molecular association, regulation; intracellular localization	endocytosis, altered	EGFR(INDUCES); Grb2(INDUCES)		10353937	2	0	1	regulates EGF-stimulated endocytosis of EGFR	
JAM-A	Cell adhesion; Membrane protein, integral	Q9Y624	50848	F11R	1q21.2-q21.3	human	T273	PHOSPHORYLATION	1783000	FDRTKKGtSSKKVIY			cytoskeletal reorganization			1713148	1	0	0	important for development of hepatic polarity	
CDH1	Cell adhesion; Membrane protein, integral; Motility/polarity/chemotaxis; UBIQUITIN LIGASE; Ubiquitin ligase	P09803	12550	Cdh1		mouse	Y755	PHOSPHORYLATION	456024	DDTRDNVyYYDEEGG	Cadherin_C	molecular association, regulation		CBLL1(INDUCES)		6565	1	1	32		
ZAK	EC 2.7.11.25; KINASE; Kinase, protein; Protein kinase, Ser/Thr (non-receptor); Protein kinase, TKL	Q9NYL2	51776	ZAK	2q24.2	human	T162	PHOSPHORYLATION	455378	SRFHNHTtHMSLVGT	Pkinase_Tyr	enzymatic activity, induced				4622	1	0	0		
RasGRP3	Guanine nucleotide exchange factor, Ras	Q5ZID9	421460	RASGRP3		chicken	T133	PHOSPHORYLATION	454419	YDWMRRVtQRKKISK		activity, induced				4307	2	0	0		
FPR1	GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Motility/polarity/chemotaxis; Receptor, GPCR	P21462	2357	FPR1	19q13.4	human	T334	PHOSPHORYLATION	450843	DSTQTSDtATNSTLP		receptor desensitization, altered; receptor internalization, altered				3130	2	0	0		
LRP6	Membrane protein, integral; Receptor, misc.	O75581	4040	LRP6	12p13.2	human	S1431	PHOSPHORYLATION	460718	GYVPHPSsLSGSLPG		molecular association, regulation		axin 1(DISRUPTS)		7726	1	0	0		
RAG2	Enzyme, misc.	P55895	5897	RAG2	11p13	human	T490	PHOSPHORYLATION	455560	EIARALHtPQRVLPL	RAG2_PHD	protein degradation; molecular association, regulation; ubiquitination	carcinogenesis, altered	SKP2(INDUCES)		18410839; 6672	3	0	0	RAG2 T490A mutation induces lymphoid malignancies	
PLK4	EC 2.7.11.21; KINASE; Kinase, protein; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor)	Q64702	20873	Plk4		mouse	S305	PHOSPHORYLATION	12122401	SGTSLSGsLLDRRLL		protein degradation; ubiquitination				12525201	2	1	0		
RFA2	DNA replication	P15927	6118	RPA2	1p35	human	S13	PHOSPHORYLATION	1854601	FESYGSSsYGGAGGY		intracellular localization	cell growth, altered			9042	3	0	0	7xAlanine mutant has defect in down regulating DNA synthesis following UV treatment. 7xAspartate mutant did not localize to S-phase foci.	
Btk	EC 2.7.10.2; KINASE; Kinase, protein; Protein kinase, TK; Protein kinase, tyrosine (non-receptor)	Q06187	695	BTK	Xq21.33-q22	human	Y223	PHOSPHORYLATION	447485	LKKVVALyDYMPMNA	SH3_1	enzymatic activity, induced	cell growth, altered			4533; 838	15	7	252	BTK*/Y223F mutant showed increased transformation, as compared to BTK*. 	
galectin-3	Cell surface; Extracellular matrix; Motility/polarity/chemotaxis	P17931	3958	LGALS3	14q22.3	human	S6	PHOSPHORYLATION	450131	__MADNFsLHDALSG		molecular association, regulation; intracellular localization	cell cycle regulation; apoptosis, inhibited	MUC1(DISRUPTS); LAMA1(DISRUPTS)		2737; 8518; 3770	7	2	0	Expression of S5 mutants of galectin-3 failed to protect cells from cisplatin-induced death and poly(ADP-ribose) polymerase from degradation when compared with wild type galectin-3.	
PCGF1	EC 6.3.2.-; Ligase; UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase	Q9BSM1	84759	PCGF1	2p13.1	human	Y109	PHOSPHORYLATION	2897401	RVMQDIVyKLVPGLQ			transcription, inhibited			8691	1	0	0		
Ikaros	C2H2-type zinc finger protein; DNA binding protein; Transcription factor	Q03267	22778	Ikzf1		mouse	S386	PHOSPHORYLATION	451350	SEREASPsNSCQDST		activity, inhibited	cell cycle regulation		DNA(DISRUPTS)	3559	1	0	4		
Rap1GAP	GTPase activating protein, Ras; Motility/polarity/chemotaxis	P47736	5909	RAP1GAP	1p36.1-p35	human	S525	PHOSPHORYLATION	450258	AGQKTPDsGHVSQEP		protein degradation				2962	1	2	0		
Chk2	EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, CAMK; Protein kinase, Ser/Thr (non-receptor)	O96017	11200	CHEK2	22q12.1	human	S73	PHOSPHORYLATION	2251701	VSTQELYsIPEDQEP	DUF966	molecular association, regulation; phosphorylation; enzymatic activity, induced	cell cycle regulation			7690	1	1	0		
TRIP6	Adaptor/scaffold; Motility/polarity/chemotaxis; Nuclear receptor co-regulator	Q15654	7205	TRIP6	7q22	human	Y55	PHOSPHORYLATION	456050	PLPSEQCyQAPGGPE		molecular association, regulation; intracellular localization	carcinogenesis, altered; cell motility, induced; cell motility, altered			27928003; 15562505; 12009	5	3	40		
Artemis	DNA repair; Deoxyribonuclease; EC 3.1.-.-	Q96SD1	64421	DCLRE1C	10p13	human	S516	PHOSPHORYLATION	460660	SSTVAGGsQSPKLFS		molecular association, regulation; ubiquitination; intracellular localization	cell cycle regulation	FBXW7(INDUCES)		7730; 7889903; 9254	8	1	1	; facilitates recovery from the replication checkpoint in response to DNA damage; Artermis regulates Cdk1-cyclin B during IR-induced G2/M arrest and Cdk1-cyclin B nuclear import.;  interaction with FBXW7 stimulates ubiquitination and degradation of cyclin E	
GCSFR	Membrane protein, integral; Receptor, cytokine	P40223	12986	Csf3r		mouse	Y788	PHOSPHORYLATION	449311	PTPSPKSyENIWFHS		activity, induced; phosphorylation				4037; 3890	4	0	0	JNK activation and SHC phosphorylation; Mutation of Y788 abolished the ability of the receptor to stimulate tyrosine phosphorylation of a cellular protein with an Mr of 54 kDa.	
CEACAM1	Cell adhesion; Immunoglobulin superfamily; Membrane protein, integral; Motility/polarity/chemotaxis	P13688	634	CEACAM1	19q13.2	human	S508	PHOSPHORYLATION	448536	QQPTQPTsASPSLTA	DUF2668	activity, induced	cell growth, altered			1608; 1609	8	0	0		
NEK7	EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor)	Q8TDX7	140609	NEK7	1q31.3	human	Y97	PHOSPHORYLATION	12475500	NHPNVIKyYASFIED	Pkinase	enzymatic activity, inhibited; protein conformation	apoptosis, altered			12343102	1	0	0	autoinhibition	
EGFR	EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Protein kinase, TK; Protein kinase, tyrosine (receptor)	P00533	1956	EGFR	7p12	human	Y1016	PHOSPHORYLATION	448055	DVVDADEyLIPQQGF		activity, induced; molecular association, regulation; intracellular localization; receptor internalization, altered; protein conformation; phosphorylation; enzymatic activity, induced	endocytosis, altered; cell motility, altered; cell adhesion, altered	SOS1(INDUCES); RASA1(INDUCES); VAV2(INDUCES); SHP-2(INDUCES); Grb2(DISRUPTS)		2651; 7071; 6509; 4843012; 5203; 1173010; 6086; 2852610; 3100; 7324129; 2309	38	3	4		
ZAP	RNA binding protein; Transferase	Q8K3Y6	252832	Zc3hav1		rat	S270	PHOSPHORYLATION	3203916	PVVSPLGsGPPSPDV		activity, induced				25227647	1	8	0		
Cbl	Adaptor/scaffold; EC 6.3.2.-; EC 6.3.2.19; Ligase; Motility/polarity/chemotaxis; UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase	P22682	12402	Cbl		mouse	Y737	PHOSPHORYLATION	448530	QQIDSCTyEAMYNIQ		phosphorylation				13788303	12	0	34	mutation reduces phosphorylation of Cbl Y780 and Akt S473	
CaMK4	EC 2.7.11.17; KINASE; Kinase, protein; Protein kinase, CAMK; Protein kinase, Ser/Thr (non-receptor)	Q16566	814	CAMK4	5q21.3	human	T200	PHOSPHORYLATION	448164	EHQVLMKtVCGTPGY	Pkinase	enzymatic activity, induced	transcription, induced; transcription, altered			3801; 2758; 6075	10	6	7		
ADD2	Cytoskeletal protein; Motility/polarity/chemotaxis	Q05764	24171	Add2		rat	S712	PHOSPHORYLATION	449802	KKKFRTPsFLKKSKK		intracellular localization	cytoskeletal reorganization			2346	5	28	154		
Ret	EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Protein kinase, TK; Protein kinase, tyrosine (receptor)	P07949	5979	RET	10q11.2	human	S891	PHOSPHORYLATION	455478	EGRKMKIsDFGLSRD	Pkinase_Tyr	phosphorylation	transcription, altered			5245	1	0	0	STAT3 Y705 phosphorylation	
LHX3	DNA binding protein; Transcription factor	Q9UBR4	8022	LHX3	9q34.3	human	S238	PHOSPHORYLATION	455299	MKRSRGGsKSDKDSV		activity, induced	transcription, induced			4438	1	0	0	no change in binding to DNA or to certain proteins (NLI, PIT1, or MRG1)	
FcER1G	Membrane protein, integral; Receptor, misc.	P20491	14127	Fcer1g		mouse	Y76	PHOSPHORYLATION	454847	NTRSQETyETLKHEK	ITAM	molecular association, regulation; phosphorylation		Syk(INDUCES)		4042517	1	7	207	increase in Syk Y346 phosphorylation in cells with wild-type FcR1G Y76	
MKL1	Transcription, coactivator/corepressor	Q969V6	57591	MKL1	22q13	human	S454	PHOSPHORYLATION	467355	TGSTPPVsPTPSERS		intracellular localization	transcription, altered			25712609; 4042513	2	20	8	stimulates MKL1 binding to G-actin and its nuclear export	
JunB	Motility/polarity/chemotaxis; Transcription factor	P17275	3726	JUNB	19p13.2	human	T255	PHOSPHORYLATION	465822	EARSRDAtPPVSPIN	Jun; HAP1_N; Jnk-SapK_ap_N	protein degradation		FBXW7(INDUCES)		27938601	1	22	16	mitosis progression and chromatid cohesion	
Cx43	Channel, misc.; Membrane protein, integral; Membrane protein, multi-pass; Motility/polarity/chemotaxis	P08050	24392	Gja1		rat	S255	PHOSPHORYLATION	448852	HATTGPLsPSKDCGS		activity, inhibited				2192	13	13	1		
G6PD	Carbohydrate Metabolism - pentose phosphate pathway; Cell development/differentiation; EC 1.1.1.49; Other Amino Acids Metabolism - glutathione; Oxidoreductase	P11413	2539	G6PD	Xq28	human	Y507	PHOSPHORYLATION	451668	GFQYEGTyKWVNPHK			cell motility, altered			7549208	1	16	755	modulates Akt activity	
p70S6K iso2	EC 2.7.11.-; EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor); Translation	P67999-2	83840	Rps6kb1		rat	S17	PHOSPHORYLATION	450117	DQPEDAGsEDELEEG		molecular association, regulation		exportin 1(INDUCES)		8244	2	0	0		
SHOX	DNA binding protein; Transcription factor	O15266	6473	SHOX	Xp22.33;Yp11.3	human	S106	PHOSPHORYLATION	457680	EKREDVKsEDEDGQT			cell cycle regulation; transcription, induced			7299	1	1	0		
cytohesin 2	Guanine nucleotide exchange factor, ARF	Q99418	9266	CYTH2	19q13.33	human	S392	PHOSPHORYLATION	450661	AARKKRIsVKKKQEQ		molecular association, regulation; intracellular localization; protein conformation		ATP6V0A2(DISRUPTS)		13164206; 3126	4	0	11		
GTSE1	Apoptosis; Cell cycle regulation	Q9NYZ3	51512	GTSE1	22q13.2-q13.3	human	S435	PHOSPHORYLATION	10405611	RSIRRRDsCLNSKTK		intracellular localization	cell cycle regulation			14780519	1	3	16	important for p53 inactivation during G2 checkpoint recovery 	
supervillin	Actin binding protein; Contractile protein; Motility/polarity/chemotaxis; Nuclear receptor co-regulator	Q6U1J6		SVIL		ferret	S132	PHOSPHORYLATION	7721700	DSEADSEsPSRYTKS		molecular association, regulation		ERK1(DISRUPTS); ERK2(DISRUPTS)		7654401	1	2	10	in vitro	
ARHGEF7	Guanine nucleotide exchange factor, Rac/Rho; Motility/polarity/chemotaxis	O55043	114559	Arhgef7		rat	S516	PHOSPHORYLATION	455215	RKPERKPsDEEFAVR		molecular association, regulation; intracellular localization	cytoskeletal reorganization	14-3-3 beta(INDUCES); RAC1(INDUCES); Cdc42 iso1(INDUCES)		1713154; 2425210; 4425	3	28	21		
PAK3	EC 2.7.1.; EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, STE; Protein kinase, Ser/Thr (non-receptor)	O75914	5063	PAK3	Xq23	human	S259	PHOSPHORYLATION	470118	TDRQRKKsKMTDEEI			cytoskeletal reorganization			9007	1	0	0	Mutation of any of the 4 serines/threonines to alanine reduced the AILIM/ICOS-induced elongation ratio in activated T cells.  Three sites are believed to be autophosphorylation sites, and one is believed to be an Akt1 site.  Treatment with Akt inhibitor shows a reduction in this elongation ratio.	
DYN2	EC 3.6.5.5; Hydrolase; Microtubule binding protein; Motility/polarity/chemotaxis; Vesicle protein	P39052	25751	Dnm2		rat	Y231	PHOSPHORYLATION	451199	LLPLRRGyIGVVNRS	Dynamin_M	molecular association, regulation; intracellular localization	carcinogenesis, induced; cell motility, induced; cell growth, induced; cytoskeletal reorganization	caveolin-1(INDUCES)		22599403; 3407	3	1	0	DYN2 Y597 is required for endocytosis and albumin transport. ; Wild-type showed increased motility and increase of large distal tumors, compared to Y231/597F mutant.	
HCN4	Channel, cation; Membrane protein, integral; Membrane protein, multi-pass	O70507	330953	Hcn4		mouse	S1142	PHOSPHORYLATION	4699522	PRKTSSGsLPPPLSL		activity, induced				15022705	1	1	0	required for PKA to shift the voltage dependence of HCN4	
ATF-4	DNA binding protein; Transcription factor	P18848	468	ATF4	22q13.1	human	S219	PHOSPHORYLATION	448436	DTPSDNDsGICMSPE		protein stabilization; molecular association, regulation	transcription, altered	BRD8 iso1(INDUCES); FBW1B(INDUCES)		1713108; 1409	3	0	0		
OLIG2	Transcription factor	Q9EQW6	50913	Olig2		mouse	S10	PHOSPHORYLATION	18357903	SDASLVSsRPSSPEP			cell cycle regulation; cell differentiation, altered; carcinogenesis, altered			18357300	1	1	0	maintains proliferation and suppresses differentiation of neural progenitors	
Gab1	Adaptor/scaffold; Motility/polarity/chemotaxis	Q9QYY0	14388	Gab1		mouse	S552	PHOSPHORYLATION	454074	ELQAPVRsPITRSFA		intracellular localization				21006100	1	1	0	recruitment  to the plasma membrane	
DAB1 iso2	Adaptor/scaffold	P97318-2	13131	Dab1		mouse	T476	PHOSPHORYLATION	479419	LTPVTSTtPSTNSPP		phosphorylation				11449	1	0	0	inhibits tyrosine phosphorylation	
HOXA9	DNA binding protein	P09631	15405	Hoxa9		mouse	T205	PHOSPHORYLATION	2906101	NWLHARStRKKRCPY		molecular association, regulation	cell differentiation, altered		DNA(DISRUPTS)	8557	1	0	0		
Rb	Nuclear receptor co-regulator; Transcription, coactivator/corepressor; Tumor suppressor	P13405	19645	Rb1		mouse	T814	PHOSPHORYLATION	447983	KISEGLPtPTKMTPR	Rb_C	molecular association, regulation		E2F1(DISRUPTS)		1258	17	16	52		
JunB	Motility/polarity/chemotaxis; Transcription factor	P17275	3726	JUNB	19p13.2	human	S259	PHOSPHORYLATION	452631	RDATPPVsPINMEDQ	HAP1_N; Jnk-SapK_ap_N	protein degradation		FBXW7(INDUCES)		27938601	3	26	18	mitosis progression and chromatid cohesion	
SNIP iso5	Cytoskeletal protein	Q9C0H9-5	80725	SRCIN1	17q12	human	Y396	PHOSPHORYLATION	456704	LVKGEGLyADPYGLL		molecular association, regulation		CSK(INDUCES)		27571206	1	11	182		
Ig-alpha	Immunoglobulin superfamily; Membrane protein, integral	P11911	12518	Cd79a		mouse	Y204	PHOSPHORYLATION	447752	SRGLQGTyQDVGNLH		activity, induced; molecular association, regulation; intracellular localization	cell differentiation, altered; cell growth, altered	BLNK(INDUCES); VAV1(INDUCES); Grb2(INDUCES)		9303; 1692; 8385; 3517; 8173	6	4	31	Ca(2+) signaling; promotes B cell activation, proliferation and differentiation.; in vitro and in vivo	
SRC-3	ACETYLTRANSFERASE; Acetyltransferase; EC 2.3.1.48; Motility/polarity/chemotaxis; Nuclear receptor co-regulator; Transcription, coactivator/corepressor	Q9Y6Q9	8202	NCOA3	20q12	human	S101	PHOSPHORYLATION	4661901	DVQKADVsSTGQGVI		protein degradation				4641435	2	0	0		
Lasp-1	Actin binding protein; Motility/polarity/chemotaxis	O77506	100009568	LASP1		rabbit	S99	PHOSPHORYLATION	450464	KNKGRGFsVVADTPE		intracellular localization	cytoskeletal reorganization			3106	1	0	0		
GCSFR	Membrane protein, integral; Receptor, cytokine	Q99062	1441	CSF3R	1p35-p34.3	human	Y787	PHOSPHORYLATION	449311	LTPSPKSyENLWFQA		activity, induced; molecular association, regulation; activity, inhibited; phosphorylation	cell growth, altered	Shc1(INDUCES); SHIP(INDUCES)		8404; 2176	4	0	0	SHIP and Shc phosphorylation	
FPR2	GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Motility/polarity/chemotaxis; Receptor, GPCR	P25090	2358	FPR2	19q13.3-q13.4	human	S236	PHOSPHORYLATION	3176601	HKKGMIKsSRPLRVL	7tm_1	receptor desensitization, altered				8619	1	0	0	downregulates PLA2 and PLD activation	
FLT3	EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Protein kinase, TK; Protein kinase, tyrosine (receptor)	P36888	2322	FLT3	13q12	human	Y969	PHOSPHORYLATION	454874	VSECPHTyQNRRPFS		molecular association, regulation	cell cycle regulation	Grb2(INDUCES)		7910519	3	1	16	regulates cell proliferation	
p53	Activator protein; DNA binding protein; Motility/polarity/chemotaxis; Nuclear receptor co-regulator; Transcription factor; Tumor suppressor	P04637	7157	TP53	17p13.1	human	T284	PHOSPHORYLATION	18675300	CPGRDRRtEEENLRK	P53		apoptosis, altered; transcription, inhibited			18378517	1	1	0		
WAVE2	Actin binding protein; Motility/polarity/chemotaxis	Q5FWU0	313024	Wasf2		rat	S137	PHOSPHORYLATION	4258800	PPPLNNLsPYRDDGK			cell motility, altered			4042529	1	0	0		
PTP1B	EC 3.1.3.48; Motility/polarity/chemotaxis; PHOSPHATASE; Phosphatase; Protein phosphatase, tyrosine (non-receptor)	P18031	5770	PTPN1	20q13.1-q13.2	human	S286	PHOSPHORYLATION	27528603	KFIMGDSsVQDQWKE		enzymatic activity, induced	apoptosis, induced			27519651	1	0	0	S286 phosphorylation promotes mitotic cell death.	
KCNK18	Channel, ligand-gated; Channel, potassium; Membrane protein, integral; Membrane protein, multi-pass	Q6VV64	332396	Kcnk18		mouse	S264	PHOSPHORYLATION	2712200	RPVERSNsCPELVLG		activity, induced; molecular association, regulation; activity, inhibited		14-3-3 gamma(INDUCES); 14-3-3 eta(INDUCES)		13354719; 12482287; 2704318	4	0	1		
HNF4 alpha	DNA binding protein; Nuclear receptor; Transcription factor	P22449	25735	Hnf4a		rat	S143	PHOSPHORYLATION	458369	RISTRRSsYEDSSLP	Foamy_virus_ENV	molecular association, regulation	transcription, altered		DNA(DISRUPTS)	12482214	2	1	12		
SLC5A5	Membrane protein, integral; Membrane protein, multi-pass; Transporter	Q63008	114613	Slc5a5		rat	S43	PHOSPHORYLATION	990307	LARGGQRsADDFFTG		activity, induced				970026	1	1	1		
RPS3	Apoptosis; Ribosomal protein; Translation	P23396	6188	RPS3	11q13.3-q13.5	human	T70	PHOSPHORYLATION	15113600	GRRIRELtAVVQKRF	KH_2	activity, induced; molecular association, regulation; intracellular localization	apoptosis, altered	E2F1(DISRUPTS); Akt1(INDUCES)		15022714	1	1	0	upregulates the endonuclease activity of RPS3	
PDE4D iso7	EC 3.1.4.17; Nucleotide Metabolism - purine; Phosphodiesterase	Q08499-7	5144	PDE4D	5q12	human	S126	PHOSPHORYLATION	458388	VHSQRREsFLYRSDS		enzymatic activity, induced				7471	8	9	0		
EXOC7	Cytoskeletal protein	O54922	64632	Exoc7		rat	S250	PHOSPHORYLATION	483909	SSSGVPYsPAIPNKR		molecular association, regulation	exocytosis, induced; cell motility, induced; cytoskeletal reorganization	EXOC4(INDUCES); EXOC8(INDUCES)		25347039	1	8	6		
p70S6K	EC 2.7.11.-; EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor); Translation	P23443	6198	RPS6KB1	17q23.1	human	T252	PHOSPHORYLATION	448606	HDGTVTHtFCGTIEY	Pkinase	protein conformation; phosphorylation; enzymatic activity, induced	translation, altered			2563; 2732; 13788309; 5011213; 5285; 2561; 1215	27	3	8		
TIF1A	Transcription initiation complex	Q9NYV6	54700	RRN3	16p12	human	S170	PHOSPHORYLATION	470001	KEGDVDVsDSDDEDD	RRN3	activity, induced; molecular association, regulation	cell cycle regulation; chromatin organization, altered; transcription, induced	TWISTNB(DISRUPTS)		2831756	1	11	2		
Deptor	Apoptosis	Q8TB45	64798	DEPTOR	8q24.12	human	S293	PHOSPHORYLATION	3897131	SSGYFSSsPTLSSSP		molecular association, regulation		BTRC(INDUCES)		21699400; 21699401	2	6	3		
GIRK1	Channel, potassium; Membrane protein, integral; Membrane protein, multi-pass	NP_113798	50599	Kcnj3		rat	S401	PHOSPHORYLATION	10769100	DISTKLPsKLQKITG		activity, induced				10425119	2	0	0		
RSK2	EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor)	P51812	6197	RPS6KA3	Xp22.2-p22.1	human	T577	PHOSPHORYLATION	450152	AENGLLMtPCYTANF	Pkinase	enzymatic activity, induced				1741	5	5	169		
EGFR	EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Protein kinase, TK; Protein kinase, tyrosine (receptor)	P00533	1956	EGFR	7p12	human	Y998	PHOSPHORYLATION	452118	SPTDSNFyRALMDEE		molecular association, regulation; receptor internalization, altered; phosphorylation		Cbl(INDUCES)		9158108	3	18	109		
MARK2	EC 2.7.11.1; EC 2.7.11.26; KINASE; Kinase, protein; Protein kinase, CAMK; Protein kinase, Ser/Thr (non-receptor)	Q7KZI7	2011	MARK2	11q13.1	human	S400	PHOSPHORYLATION	5635600	HKVQRSVsANPKQRR		molecular association, regulation; intracellular localization		14-3-3 beta(INDUCES)		5354432	1	1	0		
RALBP1	GTPase activating protein, Rac/Rho	Q15311	10928	RALBP1	18p11.3	human	S509	PHOSPHORYLATION	3136100	FLRRQIAsEKEEIER	Macoilin	activity, induced				8781	1	0	0		
CETN2	Calcium-binding protein; Cell cycle regulation; DNA repair	P41208	1069	CETN2	Xq28	human	S170	PHOSPHORYLATION	448199	LRIMKKTsLY_____		protein stabilization	cell cycle regulation; cell growth, altered			21690610; 1662	3	0	0	centrosome amplification	
IRAK1BP1	Transcription regulation	Q9ESJ7	65099	Irak1bp1		mouse	T246	PHOSPHORYLATION	12524605	AASKVFItFEVKGKE	SIMPL	intracellular localization	transcription, altered			12482402	1	0	0	nuclear localization	
HLA-DRB1	Membrane protein, integral	P18468	14969	H2-Eb1		mouse	K225	UBIQUITINATION	3597309	QSTSAQNkMLSGVGG		protein degradation	endocytosis, altered			12142	1	0	0		
KCNJ12	Membrane protein, integral; Membrane protein, multi-pass	Q14500	3768	KCNJ12	17p11.2	human	S64	PHOSPHORYLATION	3053612	FANMDEKsQRYLADM	IRK	activity, inhibited				8595	1	0	0		
P130Cas	Adaptor/scaffold; Motility/polarity/chemotaxis	P56945	9564	BCAR1	16q23.1	human	S437	PHOSPHORYLATION	8069100	SSTGSTRsSQSASSL		intracellular localization	cell motility, altered			7964804	1	1	0		
CTCF	C2H2-type zinc finger protein; Transcription factor	Q08705	396274	CTCF		chicken	S604	PHOSPHORYLATION	448302	GRKRKMRsKKEDSSD			transcription, altered; cell growth, altered			1410	1	0	1		
ERK3	EC 2.7.11.24; KINASE; Kinase, protein; Protein kinase, CMGC; Protein kinase, Ser/Thr (non-receptor)	Q16659	5597	MAPK6	15q21	human	T698	PHOSPHORYLATION	13830502	KSIQATLtPSAMKSS		protein stabilization				13326314	1	1	0		
StARD10		Q9Y365	10809	STARD10	11q13	human	S284	PHOSPHORYLATION	483984	GGAGGEGsDDDTSLT		activity, inhibited				11954	1	17	6	Inhibits lipid transfer activity in vitro	
NHE1	Membrane protein, integral; Membrane protein, multi-pass; Motility/polarity/chemotaxis; Transporter	P19634	6548	SLC9A1	1p36.1-p35	human	S729	PHOSPHORYLATION	3181649	ASPQSPEsVDLVNEE		activity, induced	apoptosis, induced			4042530	3	6	2	regulates the apoptotic alkalinizing activity of NHE1	
TBC1D1	GTPase activating protein, Rab; Ubiquitin-specific protease	Q60949	57915	Tbc1d1		mouse	T499	PHOSPHORYLATION	2228808	NRAKRSLtESLESIL		activity, inhibited				25779409	2	3	2	reduces inhibitory effect on TBC1D1 on GLUT4 translocation	
GATA4	Motility/polarity/chemotaxis; Transcription factor	P46152	54254	Gata4		rat	S261	PHOSPHORYLATION	450013	IKPQRRLsASRRVGL		activity, induced; molecular association, regulation	cell growth, induced; transcription, induced	p300(INDUCES); NKX2-5(INDUCES)	DNA(INDUCES)	2560; 22736113	6	1	1		
PDE3A	EC 3.1.4.17; Membrane protein, integral; Membrane protein, multi-pass; Nucleotide Metabolism - purine; Phosphodiesterase	Q14432	5139	PDE3A	12p12	human	S428	PHOSPHORYLATION	456821	IPKRLRRsLPPGLLR		molecular association, regulation		14-3-3 sigma(INDUCES); 14-3-3 beta(INDUCES)		6861; 7313807	3	5	1		
gp130	Membrane protein, integral; Receptor, cytokine	P40189	3572	IL6ST	5q11.2	human	Y915	PHOSPHORYLATION	448183	QTVRQGGyMPQ____			cell cycle regulation; transcription, altered			1364	2	1	3		
RPS3	Apoptosis; Ribosomal protein; Translation	P23396	6188	RPS3	11q13.3-q13.5	human	T42	PHOSPHORYLATION	455909	SGVEVRVtPTRTEII	KH_2	intracellular localization				11970	2	0	0	translocation to nucleus	
FOXM1 iso2	DNA binding protein; Transcription factor	Q08050-2	2305	FOXM1	12p13	human	T596	PHOSPHORYLATION	451437	ETLPISStPSKSVLP		molecular association, regulation	transcription, induced	CBP(INDUCES)		3642	4	3	3		
NUSAP1	Cell cycle regulation	Q9BXS6	51203	NUSAP1	15q15.1	human	S124	PHOSPHORYLATION	482179	QNHEKQEsQDLRATA			cell cycle regulation			17675055	1	1	4		
AMPKB1	Autophagy; Protein kinase, regulatory subunit	P80386	83803	Prkab1		rat	S182	PHOSPHORYLATION	448110	DVSELSSsPPGPYHQ	AMPKBI	intracellular localization				1677	3	12	1		
PLM	Cell surface; Channel, misc.; Membrane protein, integral	O08589	58971	Fxyd1		rat	S83	PHOSPHORYLATION	451424	EEGTFRSsIRRLSTR	IncA	activity, induced				1910516; 7543537	18	13	60		
Cdc25C	EC 3.1.3.48; Motility/polarity/chemotaxis; PHOSPHATASE; Protein phosphatase, dual-specificity	P30307	995	CDC25C	5q31	human	T48	PHOSPHORYLATION	448419	VCPDVPRtPVGKFLG		protein degradation; molecular association, regulation	cell cycle regulation; cell adhesion, altered	NEDD4(INDUCES); Pin1(INDUCES)		2459; 626	3	2	10		
PDX1	DNA binding protein; Transcription factor	P52947	29535	Pdx1		rat	Y68	PHOSPHORYLATION	458821	SPPDISPyEVPPLAD		activity, induced; molecular association, regulation	transcription, induced	p300(INDUCES)		7481	1	0	0		
Abl	EC 2.7.1.112; EC 2.7.10.2; KINASE; Kinase, protein; Protein kinase, TK; Protein kinase, tyrosine (non-receptor)	P00519	25	ABL1	9q34.1	human	Y139	PHOSPHORYLATION	456712	VSRNAAEyLLSSGIN	SH2	enzymatic activity, induced				6011117	2	0	57	SH2 and catalytic domains of Fes and Abl interact with ligand, stimulating kinase activity. 	
PDK1	EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor)	Q9Z2A0	18607	Pdpk1		mouse	S244	PHOSPHORYLATION	447693	SKQARANsFVGTAQY	Pkinase; YukC	enzymatic activity, induced				6553; 5608	43	48	211		
IRS1	Adaptor/scaffold; Motility/polarity/chemotaxis	P35569	16367	Irs1		mouse	S307	PHOSPHORYLATION	447558	TESITATsPASMVGG		phosphorylation				1138	62	5	0	inhibits insulin-stimulated tyrosine phosphorylation of IRS-1 	
Huntingtin	Cytoskeletal protein	P42858	3064	HTT	4p16.3	human	S13	PHOSPHORYLATION	10206805	KLMKAFEsLKSFQQQ		molecular association, regulation; intracellular localization		exportin 1(DISRUPTS)		27519631	7	1	0	nuclear exclusion	
HER2	EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Protein kinase, TK; Protein kinase, tyrosine (receptor)	P06494	24337	Erbb2		rat	Y1223	PHOSPHORYLATION	449744	SPAFDNLyYWDQNSS		molecular association, regulation	apoptosis, altered	Shc1(DISRUPTS)		12558700	19	1	10	inhibits apoptosis	
Akt1	EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor)	P31749	207	AKT1	14q32.32	human	S129	PHOSPHORYLATION	450019	SGSPSDNsGAEEMEV		enzymatic activity, induced	apoptosis, inhibited; transcription, induced			7175; 22433503	5	21	2		
TRPV1	Channel, cation; Membrane protein, integral; Membrane protein, multi-pass; Receptor, misc.	O35433	83810	Trpv1		rat	T370	PHOSPHORYLATION	455383	RHLSRKFtEWAYGPV		receptor desensitization, altered				4573	4	0	0		
FRS2	Adaptor/scaffold	Q8C180	327826	Frs2		mouse	Y196	PHOSPHORYLATION	448153	AEEQVHTyVNTTGVQ		molecular association, regulation		Grb2(INDUCES)		1356	3	1	6		
MEF2A	DNA binding protein; Motility/polarity/chemotaxis; Transcription factor	Q02078	4205	MEF2A	15q26	human	T312	PHOSPHORYLATION	448097	QATQPLAtPVVSVTT		activity, induced	transcription, altered			1159; 2504	2	0	0		
LPO	EC 1.11.1.7; Oxidoreductase; Secreted; Secreted, signal peptide	ABN41562	100860761	LPO		goat	S315	PHOSPHORYLATION	1779806	LVYGSEPsLASRLRN	An_peroxidase	enzymatic activity, induced				1713160	2	0	0	facilitates calcium ion binding to the calcium binding site	
FOXO1A	DNA binding protein; Nuclear receptor co-regulator; Transcription factor	Q9R1E0	56458	Foxo1		mouse	S253	PHOSPHORYLATION	448075	SPRRRAAsMDNNSKF	Fork_head	intracellular localization; phosphorylation	transcription, inhibited			7397604; 2895; 4904511	64	3	35	cytoplasmic localization induced by genistein and estradiol in female mice; promotes further FOXO1A phosphorylation	
p16-INK4A	Cell cycle regulation	P42771	1029	CDKN2A	9p21	human	S8	PHOSPHORYLATION	448830	MEPAAGSsMEPSADW		protein stabilization; activity, inhibited				13159405; 18119108	3	0	0		
AHCYL1	Amino Acid Metabolism - cysteine and methionine; EC 3.3.1.1; Hydrolase; Other Amino Acids Metabolism - selenoamino acid	Q80SW1	229709	Ahcyl1		mouse	S71	PHOSPHORYLATION	467245	SRSISQSsTDSYSSA	Utp11	molecular association, regulation		IP3R1(INDUCES)		8190	3	1	0	binding to IP3R1 supresses its binding to IP3 and inhibits IP3-induced calcium release 	
CSF2RB	Membrane protein, integral; Receptor, cytokine	P32927	1439	CSF2RB	22q13.1	human	S601	PHOSPHORYLATION	448463	LGPPHSRsLPDILGQ		activity, induced; molecular association, regulation; phosphorylation	apoptosis, inhibited; transcription, altered	14-3-3 beta(INDUCES); PIK3R1(INDUCES)		1020; 10274621; 3010	6	0	0	S601 is important for NF-kB and Akt activation, and Bcl-2 expression. 	
RIMS1	Adaptor/scaffold; Vesicle protein	Q9JIR4	84556	Rims1		rat	S241	PHOSPHORYLATION	455663	RLQERSRsQTPLSTA		molecular association, regulation		14-3-3 beta(INDUCES); 14-3-3 gamma(INDUCES); 14-3-3 eta(INDUCES)		5833	1	1	0		
PAR3-alpha	Adaptor/scaffold; Motility/polarity/chemotaxis	Q9Z340	81918	Pard3		rat	T833	PHOSPHORYLATION	2512944	QSMSEKRtKQFSNAS		molecular association, regulation	cell motility, altered; cytoskeletal reorganization	PARD6A(DISRUPTS); PKCI(DISRUPTS)		2425218	1	0	0		
FLOT2	Cell adhesion	Q9Z2S9	83764	Flot2		rat	Y163	PHOSPHORYLATION	475941	DVYDKVDyLSSLGKT	Band_7	molecular association, regulation; intracellular localization	cell motility, altered; cytoskeletal reorganization	FLOT1(INDUCES)		7324308; 9297	3	1	18		
RAF1	EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, Ser/Thr (non-receptor); Protein kinase, TKL	P04049	5894	RAF1	3p25	human	S43	PHOSPHORYLATION	447744	FGYQRRAsDDGKLTD		molecular association, regulation; intracellular localization; enzymatic activity, inhibited		14-3-3 beta(INDUCES); HRas(DISRUPTS)		6879; 4487; 1855	17	8	5		
DDX3	Cell cycle regulation; EC 3.6.1.-; EC 3.6.4.13; Helicase; Spliceosome; Translation initiation; Tumor suppressor	O00571	1654	DDX3X	Xp11.3-p11.23	human	T204	PHOSPHORYLATION	457783	LTRYTRPtPVQKHAI	DEAD	enzymatic activity, inhibited	translation, altered; cell growth, altered			8475010; 7310	2	1	0		
PTPN3	EC 3.1.3.48; Motility/polarity/chemotaxis; Protein phosphatase, tyrosine (non-receptor)	P26045	5774	PTPN3	9q31	human	S835	PHOSPHORYLATION	451192	VRSLRVDsEPVLVHC	Y_phosphatase	molecular association, regulation		14-3-3 beta(INDUCES)		3393	1	0	1		
WASP	Adaptor/scaffold; Motility/polarity/chemotaxis	P42768	7454	WAS	Xp11.4-p11.21	human	S484	PHOSPHORYLATION	449295	RSRAIHSsDEGEDQA		molecular association, regulation	cytoskeletal reorganization	ARPC3(INDUCES)		2167	2	9	0	The double mutant (S483A/S484A) was used in this study.	
MDM2	EC 6.3.2.-; EC 6.3.2.19; Inhibitor protein; Ligase; UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase	P23804	17246	Mdm2		mouse	S183	PHOSPHORYLATION	448131	RHRKRRRsLSFDPSL			apoptosis, altered; carcinogenesis, altered			17630303	10	5	1	Coexpression of S163/183DD with Neu results in faster tumor formation. 	
CDH5	Cell adhesion; Membrane protein, integral; Motility/polarity/chemotaxis	P55284	12562	Cdh5		mouse	Y645	PHOSPHORYLATION	2028403	IHEQLVTyDEEGGGE	Cadherin_C		cell motility, altered			1968313	1	0	0	affects cell migration and increased endothelial cell barrier permeability	
hnRNP C1/C2	RNA binding protein; RNA splicing; Spliceosome	P07910	3183	HNRNPC	14q11.2	human	S253	PHOSPHORYLATION	448835	ETNVKMEsEGGADDS	Alpha-2-MRAP_C; DUF2422; RP-C_C	molecular association, regulation			RNA(NOT_REPORTED)	4574	2	20	17		
TPPP	Cytoskeletal protein	O94811	11076	TPPP	5p15.3	human	S160	PHOSPHORYLATION	487536	GVTKAISsPTVSRLT	p25-alpha; DUF1018		cytoskeletal reorganization			12255	1	7	0	ERK2 phosphorylation of TPPP induces formation of tubulin assemblies. 	
IRF7	DNA binding protein; Transcription factor	Q92985	3665	IRF7	11p15.5	human	S471	PHOSPHORYLATION	1276102	GTQREGVsSLDSSSL			transcription, inhibited			8586	3	0	0		
Fos	DNA binding protein; Motility/polarity/chemotaxis; Transcription factor	P12841	314322	Fos		rat	T325	PHOSPHORYLATION	448483	TELEPLCtPVVTCTP		activity, induced; molecular association, regulation	transcription, altered		DNA(INDUCES)	2626208	5	0	1		
P2X3	Channel, ligand-gated; Membrane protein, integral; Membrane protein, multi-pass	P49654	81739	P2rx3		rat	Y393	PHOSPHORYLATION	9486200	QSTDSGAySIGH___		activity, inhibited				9158104	1	0	0		
HSP27	Chaperone; Motility/polarity/chemotaxis	P15991		HSPB1		hamster	S90	PHOSPHORYLATION	448403	RALNRQLsSGVSEIR		activity, induced; molecular association, regulation	apoptosis, altered	IKKA(INDUCES); HSP27(DISRUPTS)		2531306; 4676; 4030; 7036	44	56	263		
catalase	Amino Acid Metabolism - tryptophan; Apoptosis; EC 1.11.1.6; Endoplasmic reticulum; Energy Metabolism - methane; Hydrolase; Mitochondrial; Oxidoreductase	P04040	847	CAT	11p13	human	Y386	PHOSPHORYLATION	450445	YRARVANyQRDGPMC	Catalase	enzymatic activity, induced				2998	2	0	0		
APC	Motility/polarity/chemotaxis; Tumor suppressor	P25054	324	APC	5q21-q22	human	S2034	PHOSPHORYLATION	454100	LSSLSIDsEDDLLQE	SAMP	intracellular localization				4209	1	0	0		
STMN2	Cytoskeletal protein	P55821	20257	Stmn2		mouse	S73	PHOSPHORYLATION	450173	EAPRTLAsPKKKDLS	Stathmin; CDC37_N	activity, inhibited	cell motility, altered; cytoskeletal reorganization			7858; 18410818	5	0	0	phospho-mimetic S62D/S73D mutant stabilizes microtubules; inhibits microtubule depolymerization activity of STMN2 (SCG10).  	
ALDOA	Carbohydrate Metabolism - fructose and mannose; Carbohydrate Metabolism - glycolysis and gluconeogenesis; Carbohydrate Metabolism - pentose phosphate pathway; EC 4.1.2.13; KINASE; Lyase; Mitochondrial	P00883	100009055	ALDOA		rabbit	H362	PHOSPHORYLATION	451798	ESLFISNhAY_____	Glycolytic	enzymatic activity, inhibited				3528	1	0	0		
CLCN3 iso2	Channel, chloride; Membrane protein, integral; Membrane protein, multi-pass; Vesicle protein	P51792-2				rat	Y284	PHOSPHORYLATION	3577859	FSLEEVSyYFPLKTL	Voltage_CLC	activity, induced	apoptosis, inhibited			27902310	1	0	0	channel activation	
eIF5	Translation; Translation initiation	P55010	1983	EIF5	14q32.32	human	S390	PHOSPHORYLATION	448030	KEAEEESsGGEEEDE	W2	molecular association, regulation	cell cycle regulation; translation, altered	eIF2-alpha(INDUCES)		3309502; 6983	3	31	43		
RSK2	EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor)	P51812	6197	RPS6KA3	Xp22.2-p22.1	human	S227	PHOSPHORYLATION	448063	DHEKKAYsFCGTVEY	Pkinase	enzymatic activity, induced				1741; 30280007	8	21	132		
hnRNP C1/C2	RNA binding protein; RNA splicing; Spliceosome	P07910	3183	HNRNPC	14q11.2	human	Y57	PHOSPHORYLATION	2811401	KGFAFVQyVNERNAR	RRM_1	molecular association, regulation			RNA(INDUCES)	2807229	1	0	1	Northwestern analysis, RNA stabilization	
PLZF	C2H2-type zinc finger protein; DNA binding protein; Transcription, coactivator/corepressor	Q05516	7704	ZBTB16	11q23.1	human	S197	PHOSPHORYLATION	2134715	SFGLSAMsPTKAAVD		protein degradation	cell cycle regulation; transcription, altered; cell growth, altered			2133205	1	0	0		
DLG1	Adaptor/scaffold; Motility/polarity/chemotaxis	Q62696	25252	Dlg1		rat	S232	PHOSPHORYLATION	451615	ITLERGNsGLGFSIA	PDZ	molecular association, regulation		NMDAR2A(DISRUPTS)		12482264; 9102	3	5	0		
DAP3	Apoptosis; Mitochondrial; Nuclear receptor co-regulator	P51398	7818	DAP3	1q22	human	T216	PHOSPHORYLATION	2226202	VWNKREStEKGSPLG	DAP3		apoptosis, induced			2195711	1	1	0		
ORAI1	Channel, calcium; Membrane protein, integral; Membrane protein, multi-pass	Q96D31	84876	ORAI1	12q24.31	human	S30	PHOSPHORYLATION	14932000	TTSGSRRsRRRSGDG		activity, inhibited				14780529	2	0	0		
IGF1R	EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Protein kinase, TK; Protein kinase, tyrosine (receptor)	Q60751	16001	Igf1r		mouse	Y1168	PHOSPHORYLATION	448388	DIYETDYyRKGGKGL	Pkinase_Tyr	enzymatic activity, induced				2500	9	11	108		
Ret	EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Protein kinase, TK; Protein kinase, tyrosine (receptor)	P07949	5979	RET	10q11.2	human	T675	PHOSPHORYLATION	22553316	PISSAEMtFRRPAQA		intracellular localization	signaling pathway regulation			22463941	1	0	0	modulates GDNF-induced downstream signaling and cell differentiation	
FEN1	DNA binding protein; DNA repair; Deoxyribonuclease; EC 3.1.-.-; Ribonuclease	P39748	2237	FEN1	11q12	human	R192	METHYLATION	15550800	FGSPVLMrHLTASEA	XPG_I	molecular association, regulation; intracellular localization; phosphorylation	cell cycle regulation	PCNA(INDUCES)		15278806	1	1	0		
PDGFRA	EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Protein kinase, TK; Protein kinase, tyrosine (receptor)	P16234	5156	PDGFRA	4q12	human	Y720	PHOSPHORYLATION	452056	ADESTRSyVILSFEN	Pkinase_Tyr	molecular association, regulation		SHP-2(INDUCES)		6024; 4332; 4007	5	2	2		
NOLC1	Transcription, coactivator/corepressor	P41777	64896	Nolc1		rat	S628	PHOSPHORYLATION	455686	KGEKRASsPFRRVRE	SRP40_C	activity, induced	transcription, altered			6382	1	17	13		
FBXW7	Motility/polarity/chemotaxis; UBIQUITIN LIGASE; Ubiquitin conjugating system	Q969H0	55294	FBXW7	4q31.3	human	S176	PHOSPHORYLATION	25126709	KRKLDHGsEVRSFSL	Astro_capsid; Nop14	protein degradation	cytoskeletal reorganization			25082807	1	1	0	Phosphorylation prevents ubiquitin-dependent degradation of cyclin E and subsequent centriole duplication.	
CFLAR iso2	Apoptosis	O15519-2	8837	CFLAR	2q33-q34	human	S193	PHOSPHORYLATION	7590803	LQAAIQKsLKDPSNN		protein stabilization; ubiquitination				7549219	1	1	0		
IP3R1	Channel, calcium; Channel, ligand-gated; Membrane protein, integral; Membrane protein, multi-pass; Receptor, misc.	Q14643	3708	ITPR1	3p26.1	human	S1598	PHOSPHORYLATION	450681	RNAARRDsVLAASRD		molecular association, regulation		calmodulin(DISRUPTS)		12262	8	26	2	regulates calcium dependent binding	
TPM1	Actin binding protein; Motility/polarity/chemotaxis; Motor protein	P09493	7168	TPM1	15q22.1	human	S61	PHOSPHORYLATION	456510	EDELDKYsEALKDAQ	DUF869; MscS_porin; Laminin_I; IncA; Laminin_II; Flagellin_N; Tropomyosin; Myosin_tail_1; TMF_DNA_bd	intracellular localization				6680	1	2	5	phosphorylation of site is critical for agonist-stimulated  beta-adrenergic receptor endocytosis.	
p57Kip2 iso2	Inhibitor protein; Nuclear receptor co-regulator	P49919-2	12577	Cdkn1c		mouse	T143	PHOSPHORYLATION	25525402	ADATPPAtPAPASDL		molecular association, regulation	cell cycle regulation	CDK2(INDUCES)		25347024	1	0	0	promotes cell survival upon osmostress	
PPP1R12C	Protein phosphatase, regulatory subunit	Q9BZL4	54776	PPP1R12C	19q13.42	human	S452	PHOSPHORYLATION	472608	AGLQRSAsSSWLEGT		molecular association, regulation		14-3-3 zeta(INDUCES)		25220601	1	10	40	mitotic progression 	
FOXO4	DNA binding protein; Transcription factor	P98177	4303	FOXO4	Xq13.1	human	S197	PHOSPHORYLATION	448516	APRRRAAsMDSSSKL	Fork_head	intracellular localization	apoptosis, altered; transcription, inhibited			448; 447; 6115915; 8512	12	1	5		
Fyn	EC 2.7.10.2; KINASE; Kinase, protein; Protein kinase, TK; Protein kinase, tyrosine (non-receptor)	P06241	2534	FYN	6q21	human	S21	PHOSPHORYLATION	1983273	LTEERDGsLNQSSGY		intracellular localization; phosphorylation; enzymatic activity, induced	cell motility, altered			15026109	1	20	12		
Per1	Transcription factor	O35973	18626	Per1		mouse	S714	PHOSPHORYLATION	465536	ALANKAEsVVSVTSQ		phosphorylation				7978	1	0	0	implicated in regulation of phosphorylation of other CK1epsilon sites	
STX1A	Membrane protein, integral; Vesicle protein	P32851	116470	Stx1a		rat	S14	PHOSPHORYLATION	451261	ELRTAKDsDDDDDVT	MCPsignal; ApoLp-III	molecular association, regulation	exocytosis, altered	SNAP-25(INDUCES)		17675050; 4387	4	12	4		
GRK2	EC 2.7.11.15; KINASE; Kinase, protein; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor)	P25098	156	ADRBK1	11q13.1	human	S29	PHOSPHORYLATION	447724	ATPAARAsKKILLPE		activity, induced				1106	2	0	0		
Ces1d		NP_579829	113902	Ces1d		rat	S506	PHOSPHORYLATION	3540200	ANFARNGsPNGGGLP	COesterase	enzymatic activity, induced				5789	1	0	0	increases cholesterol esterase activities and decreases PNPA esterase (change of substrate specificity from water soluble to hydrophobic substrates)	
RA70	Adaptor/scaffold	Q9Z2K4	54353	Skap2		mouse	Y260	PHOSPHORYLATION	449668	QPIDDEIyEELPEEE		molecular association, regulation	cell growth, altered	Lyn(INDUCES); Hck(INDUCES); Fyn(INDUCES)		8652	2	5	100		
CTNND1	Actin binding protein; Adaptor/scaffold; Cell adhesion; G protein regulator, misc.; Motility/polarity/chemotaxis	P30999	12388	Ctnnd1		mouse	Y280	PHOSPHORYLATION	450398	HRFHPEPyGLEDDQR			cell cycle regulation; cell motility, altered			2790302	2	13	164		
HMGN1	DNA binding protein	P05114	3150	HMGN1	21q22.2	human	S8	PHOSPHORYLATION	465531	MPKRKVSsAEGAAKE	HMG14_17	intracellular localization				8551	2	4	4	Phosphorylation facilitates localization to non-nuclear pools.	
STAP2	Adaptor/scaffold	Q9UGK3	55620	STAP2	19p13.3	human	Y322	PHOSPHORYLATION	3974222	GDGPAVDyENQDVAS		molecular association, regulation	transcription, altered	STAT3(INDUCES)		10294000	1	1	6		
dCK	EC 2.7.1.74; Kinase, other; Nucleotide Metabolism - purine; Nucleotide Metabolism - pyrimidine	P27707	1633	DCK	4q13.3-q21.1	human	S74	PHOSPHORYLATION	456305	EFEELTMsQKNGGNV	PRK	protein conformation; enzymatic activity, induced				7687; 15026116; 2875300; 18797401; 2195499; 14851000	9	15	89		
ER-alpha	DNA binding protein; Nuclear receptor	P03372	2099	ESR1	6q25.1	human	S167	PHOSPHORYLATION	448102	GGRERLAsTNDKGSM	Oest_recep	activity, induced; acetylation; molecular association, regulation	apoptosis, inhibited; transcription, induced; transcription, altered; cell growth, altered	SRC-3(INDUCES)	DNA(NOT_REPORTED)	3390; 1926905; 2626; 2315; 6238; 7613706; 665; 4888108; 11006907; 13788307; 4734; 4894700	34	3	0		
ezrin	Cytoskeletal protein; Motility/polarity/chemotaxis	P15311	7430	EZR	6q25.3	human	S66	PHOSPHORYLATION	458400	LKLDKKVsAQEVRKE	FERM_N	intracellular localization	cytoskeletal reorganization			7475; 7446	2	1	0	important for proton pump translocation to the apical membrane	
AhR	DNA binding protein; Nuclear receptor; Transcription factor	P41738	25690	Ahr		rat	T385	PHOSPHORYLATION	3798901	IATQRPLtDEEGREH			transcription, altered			4440	1	0	0		
Src	EC 2.7.10.2; KINASE; Kinase, protein; Protein kinase, TK; Protein kinase, tyrosine (non-receptor)	P05480	20779	Src		mouse	Y535	PHOSPHORYLATION	448235	FTSTEPQyQPGENL_		molecular association, regulation; enzymatic activity, inhibited	cell growth, altered	afadin(DISRUPTS); Grb2(INDUCES)		7550819; 6475; 1173018	104	13	966	growth and transformation regulated through Cul5	
emerin	Cytoskeletal protein; Membrane protein, integral	P50402	2010	EMD	Xq28	human	S175	PHOSPHORYLATION	457527	RPVSASRsSLDLSYY	PknH_C	molecular association, regulation		BAF(DISRUPTS)		6984	1	4	0		
vimentin	Cytoskeletal protein; Motility/polarity/chemotaxis	P20152	22352	Vim		mouse	S39	PHOSPHORYLATION	451766	TTSTRTYsLGSALRP	Filament_head; DUF2464		cell motility, altered; cytoskeletal reorganization			18410842; 2057	16	24	28		
NPM-ALK	Kinase, protein; Protein kinase, TK; Protein kinase, tyrosine (receptor)	AAA58698		NPM/ALK		human	Y156	PHOSPHORYLATION	27275109	MTDYNPNyCFAGKTS		molecular association, regulation	transcription, induced	SNTB1(INDUCES); IRS1(INDUCES)		3299; 2852671; 9127	3	2	0		
ARAF	EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, Ser/Thr (non-receptor); Protein kinase, TKL	P10398	369	ARAF	Xp11.4-p11.2	human	T455	PHOSPHORYLATION	3306307	FGLATVKtRWSGAQP	Pkinase_Tyr	enzymatic activity, induced				3301229	0	1	1		
GPIbA	Cell adhesion; Cell surface; Membrane protein, integral	P07359	2811	GP1BA	17pter-p12	human	S603	PHOSPHORYLATION	1983276	LVAGRRPsALSQGRG		molecular association, regulation		14-3-3 zeta(INDUCES)		13164200	3	6	10		
SIAH1	Apoptosis; Cell development/differentiation; EC 6.3.2.-; EC 6.3.2.19; Ligase; Motility/polarity/chemotaxis; UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase	Q8IUQ4	6477	SIAH1	16q12.1	human	Y126	PHOSPHORYLATION	457102	ELCEFRPySCPCPGA	Sina	protein stabilization	apoptosis, altered			7019	1	0	0		
PSRC1	Tumor suppressor	Q6PGN9	84722	PSRC1	1p13.3	human	S22	PHOSPHORYLATION	18912817	TLDFGGLsPSDSREE			cytoskeletal reorganization			18898704	1	3	0		
PKCT	EC 2.7.11.13; KINASE; Kinase, protein; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor)	Q04759	5588	PRKCQ	10p15	human	T538	PHOSPHORYLATION	447907	LGDAKTNtFCGTPDY	Pkinase	enzymatic activity, induced	signaling pathway regulation; transcription, altered			22463907; 6963; 1630	11	4	16		
Cdc34	EC 6.3.2.19; Ligase; UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase	P49427	997	CDC34	19p13.3	human	T233	PHOSPHORYLATION	448689	DDEDDSGtEES____		intracellular localization				1868	2	0	0		
HSF1	DNA binding protein; Transcription factor	Q00613	3297	HSF1	8q24.3	human	S320	PHOSPHORYLATION	3849409	ASPGRPSsVDTLLSP	Vert_HS_TF	activity, induced; intracellular localization	transcription, induced			17431532	3	3	1		
PSEN2	Cell surface; EC 3.4.23.-; Membrane protein, integral; Membrane protein, multi-pass; Protease	P49810	5664	PSEN2	1q31-q42	human	S330	PHOSPHORYLATION	448567	MEEDSYDsFGEPSYP	Presenilin	protein stabilization	apoptosis, inhibited			1250	2	0	0	Phosphorylation of Presenilin 2 inhibits its cleavage by caspase-3.	
ADRA2A	GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR	P08913	150	ADRA2A	10q25.2	human	S297	PHOSPHORYLATION	456350	ALDLEESsSSDHAER	7tm_1	activity, inhibited				6726	1	2	0		
LHR	GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR	P16235	25477	Lhcgr		rat	S665	PHOSPHORYLATION	451063	KEFSAYTsNCKNGFP		receptor internalization, altered				3286	1	0	0	S665 is required for agonist-induced uncoupling and internalization. 	
ORC2	DNA replication	Q13416	4999	ORC2	2q33	human	T116	PHOSPHORYLATION	3195386	LASELAKtPQKSVSF		molecular association, regulation	cell cycle regulation		DNA(DISRUPTS)	23260340	2	6	9	dissociates Orc2-5 subunits from chromatin and replication origins	
TXA2-R	GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR	P30987	21390	Tbxa2r		mouse	T226	PHOSPHORYLATION	3061801	TLCRVYHtREATQRP	7tm_1	receptor desensitization, altered				8538	1	0	0	GRK2 mediated but not PKC 	
BRAF	EC 2.7.1.37; EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, Ser/Thr (non-receptor); Protein kinase, TKL	P15056	673	BRAF	7q34	human	S365	PHOSPHORYLATION	450243	GQRDRSSsAPNVHIN		enzymatic activity, inhibited	transcription, altered; cell growth, altered			4264910; 1748; 6588	7	14	30		
GTF2F1	EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, Ser/Thr (non-receptor); Transcription initiation complex	P35269	2962	GTF2F1	19p13.3	human	S385	PHOSPHORYLATION	483594	GGSSRGNsRPGTPSA	TFIIF_alpha	activity, inhibited	transcription, inhibited			2852646	1	21	187	slows down RNA pol II elongation	
P38A	EC 2.7.1.37; EC 2.7.11.24; KINASE; Kinase, protein; Protein kinase, CMGC; Protein kinase, Ser/Thr (non-receptor)	Q16539	1432	MAPK14	6p21.3-p21.2	human	Y323	PHOSPHORYLATION	455799	DEPVADPyDQSFESR		phosphorylation; enzymatic activity, induced				6128	5	0	0		
Bcl-2	Apoptosis; Autophagy; Membrane protein, integral	P10417	12043	Bcl2		mouse	S70	PHOSPHORYLATION	448395	RDMAARTsPLRPLVA		molecular association, regulation; protein stabilization	cell cycle regulation; apoptosis, inhibited	Bax(INDUCES)		2723; 8902; 6406; 4264909; 4558	35	1	0		
axin 1	Adaptor/scaffold	O70239	79257	Axin1		rat	T480	PHOSPHORYLATION	451091	HVQRVMRtPGCQSPG	Axin_b-cat_bind		cytoskeletal reorganization			25797201	4	2	0	Phosphorylation regulates responsive to Sema3A induced growth cone collapse.	
HP1 alpha	Transcription, coactivator/corepressor	Q61686	12419	Cbx5		mouse	S12	PHOSPHORYLATION	3190486	TKRTADSsSSEDEEE		molecular association, regulation		H3(INDUCES)	DNA(INDUCES)	18021019	1	18	1	important for chromosomal stability	
CTNND1	Actin binding protein; Adaptor/scaffold; Cell adhesion; G protein regulator, misc.; Motility/polarity/chemotaxis	P30999	12388	Ctnnd1		mouse	K623	ACETYLATION	15292745	ASCFGAKkGKDEWFS			cytoskeletal reorganization			8130	0	1	1		
FURIN	Cell surface; EC 3.4.21.75; Membrane protein, integral; Protease; Vesicle protein	P09958	5045	FURIN	15q26.1	human	S775	PHOSPHORYLATION	469743	QEECPSDsEEDEGRG		intracellular localization				12660609	1	5	0	retrieval to the trans-Golgi network	
PPP2R5D	Motility/polarity/chemotaxis; Protein phosphatase, regulatory subunit	Q7TNL5	21770	Ppp2r5d		mouse	S53	PHOSPHORYLATION	457388	PSSNKRPsNSTPPPT		enzymatic activity, induced				12778805	5	0	0		
LKB1	Autophagy; EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, CAMK; Protein kinase, Ser/Thr (non-receptor)	Q15831	6794	STK11	19p13.3	human	T402	PHOSPHORYLATION	11454702	TEAAQLStKSRAEGR		enzymatic activity, induced				10296905	1	0	0	STRAD increases LKB1 activation 	
Pyk2	EC 2.7.10.2; KINASE; Kinase, protein; Nuclear receptor co-regulator; Protein kinase, TK; Protein kinase, tyrosine (non-receptor)	P70600	50646	Ptk2b		rat	Y580	PHOSPHORYLATION	447957	YIEDEDYyKASVTRL	Pkinase_Tyr	enzymatic activity, induced				1252	15	18	994		
CHOP	Autophagy; DNA binding protein; Transcription factor	P35638	1649	DDIT3	12q13.1-q13.2	human	S15	PHOSPHORYLATION	455502	FSFGTLSsWELEAWY		activity, inhibited	transcription, inhibited			5475	1	0	0		
IKKA	EC 2.7.11.10; KINASE; Kinase, protein; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor)	Q60680	12675	Chuk		mouse	S180	PHOSPHORYLATION	447779	DQGSLCTsFVGTLQY	Pkinase	enzymatic activity, induced	apoptosis, altered; cell growth, altered			6782009; 6801	32	0	0	IKK-alpha/beta are effectors of B-Raf mediated survival. 	
ICAM3	Cell adhesion; Immunoglobulin superfamily; Membrane protein, integral	P32942	3385	ICAM3	19p13.3-p13.2	human	S516	PHOSPHORYLATION	451212	VFREHQRsGSYHVRE		intracellular localization				3443	1	0	0		
PU.1	DNA binding protein; Transcription factor	P17433	20375	Spi1		mouse	S148	PHOSPHORYLATION	455900	QSPPLEVsDGEADGL		activity, induced; molecular association, regulation	RNA splicing, altered; transcription, induced; transcription, altered	IRF4(INDUCES); IRF8(INDUCES); PIP(INDUCES); PU.1(INDUCES); IRF8(NOT_REPORTED); IRF2(INDUCES)	DNA(INDUCES)	7324119; 9577; 3281; 13354736; 3269	5	1	0		
TIE2	EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Protein kinase, TK; Protein kinase, tyrosine (receptor)	Q02763	7010	TEK	9p21	human	Y1108	PHOSPHORYLATION	448372	TYVNTTLyEKFTYAG		enzymatic activity, induced				15755110	4	0	1		
ILT2	Membrane protein, integral; Receptor, misc.	Q8N423	10288	LILRB2	19q13.4	human	Y592	PHOSPHORYLATION	464930	PPAEPSIyATLAIH_		molecular association, regulation		CSK(INDUCES); SHP-1(INDUCES)		4315; 3538	2	0	1	Mutation of Y533 prevented binding in vivo. 	
MOB1B	Activator protein; Protein kinase, regulatory subunit	Q7L9L4	92597	MOB1B	4q13.3	human	T35	PHOSPHORYLATION	3545001	LLKHAEAtLGSGNLR	Mob1_phocein	molecular association, regulation; phosphorylation	cell cycle regulation; cell growth, altered	NDR1(INDUCES); NDR2(INDUCES); LATS1(INDUCES); LATS2(INDUCES)		11424218; 3301221	2	22	28		
MCM4	DNA replication; EC 3.6.4.12	P33991	4173	MCM4	8q11.2	human	S32	PHOSPHORYLATION	450001	RSEDARSsPSQRRRG		activity, inhibited				2551	2	5	9		
SLC6A12	Membrane protein, integral; Membrane protein, multi-pass; Transporter	P27799	404013	SLC6A12		dog	T612	PHOSPHORYLATION	454881	LIVGEKEtHL_____		molecular association, regulation; phosphorylation		LIN7C(DISRUPTS)		4360	1	0	0		
CTMP		Q5T1C6	117145	THEM4	1q21	human	S37	PHOSPHORYLATION	9721501	RPELRSFsSEEVILK		intracellular localization				9689409	1	1	0		
EGFR	EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Protein kinase, TK; Protein kinase, tyrosine (receptor)	P00533	1956	EGFR	7p12	human	S1026	PHOSPHORYLATION	451640	PQQGFFSsPSTSRTP		activity, inhibited				3722	2	4	0		
S6	Translation	P62753	6194	RPS6	9p21	human	S236	PHOSPHORYLATION	448093	AKRRRLSsLRASTSK	DUF4055	molecular association, regulation			RNA(INDUCES)	11812	125	34	1097	7-methylguanosine cap	
MOK	EC 2.7.11.22; KINASE; Kinase, protein; Protein kinase, CMGC; Protein kinase, Ser/Thr (non-receptor)	Q9UQ07	5891	MOK	14q32	human	T159	PHOSPHORYLATION	450005	VYSKQPYtEYISTRW	Pkinase	activity, induced				2553	1	0	0	While the authors did not prove that these sites were phosphorylated, mutation of both T159 and Y161, located in the activation loop, abolished the enzymatic activity of the kinase.	
NFAT3	DNA binding protein; Transcription factor	Q8K120	73181	Nfatc4		mouse	S170	PHOSPHORYLATION	448860	GGAFFSPsPGSSSLS		activity, inhibited	transcription, altered			4215307; 4049508	5	0	1		
E2A	DNA binding protein; Transcription factor	NP_001157619	21423	Tcf3		mouse	S140	PHOSPHORYLATION	455905	LSSPGPLsPSGIKSS		molecular association, regulation	cell differentiation, altered; transcription, altered	MyoD(INDUCES)		8430	2	3	0		
NME1	EC 2.7.4.6; KINASE; Kinase, nucleoside diphosphate; Kinase, other; Nucleotide Metabolism - purine; Nucleotide Metabolism - pyrimidine; Tumor suppressor	P15531	4830	NME1	17q21.3	human	S44	PHOSPHORYLATION	450096	GLKFMQAsEDLLKEH	NDK		cell growth, altered			2918	4	0	1	inhibits colony formation in soft agar	
NPM1	RNA binding protein; Translation	P06748	4869	NPM1	5q35.1	human	K257	ACETYLATION	3284526	KMQASIEkGGSLPKV	Nop14; TFIIF_alpha	molecular association, regulation; intracellular localization	transcription, altered	H3(INDUCES)		8156707	1	2	1	K212/215/229/230/257/267/292R  mutant	
MC2R	GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR	Q01718	4158	MC2R	18p11.2	human	S208	PHOSPHORYLATION	456021	RSHTRKIsTLPRANM	7tm_1	receptor desensitization, altered				6572	1	0	0		
SMN	RNA binding protein; RNA processing	Q16637	6606	SMN1	5q13.2	human	S31	PHOSPHORYLATION	454889	GTGQSDDsDIWDDTA	SMN	activity, induced; molecular association, regulation		SMN(INDUCES)		4361; 17482918	2	37	25	possible SMN oligomerization 	
amphiphysin	Vesicle protein	Q7TQF7	218038	Amph		mouse	T260	PHOSPHORYLATION	3147510	GPLRIAKtPSPPEEP			endocytosis, altered			4049510	1	7	1		
Mpl	Membrane protein, integral; Receptor, cytokine	Q08351	17480	Mpl		mouse	S568	PHOSPHORYLATION	3091405	ILPKSSEsTPLPLCP		activity, induced; phosphorylation	cell growth, altered			8388	1	0	0	tyrosine phosphorylation of JAK2	
calsequestrin 2	Calcium-binding protein	P12637	483134	CASQ2		dog	S401	PHOSPHORYLATION	451475	GNNSDEEsNDDSDDD		intracellular localization				18759800	2	1	0	regulates intracellular trafficking of calsequestrin 2	
HSL	EC 3.1.1.79; Lipase	Q05469	3991	LIPE	19q13.2	human	S853	PHOSPHORYLATION	448803	IAEPMRRsVSEAALA		enzymatic activity, induced				6702314	21	6	2		
DLX5	DNA binding protein; Transcription factor	P70396	13395	Dlx5		mouse	S34	PHOSPHORYLATION	1725302	MHHPSQEsPTLPESS	DLL_N		transcription, induced			1713113	1	0	0	measured by Osx mRNA levels	
HDAC9	DEACETYLASE; Deacetylase; EC 3.5.1.98; Transcription, coactivator/corepressor	Q9UKV0	9734	HDAC9	7p21.1	human	S253	PHOSPHORYLATION	13204427	KDGNVVTsFKKRMFE		intracellular localization				13164207	1	0	0		
Gab2	Adaptor/scaffold	Q9UQC2	9846	GAB2	11q14.1	human	S159	PHOSPHORYLATION	448382	LLRERKSsAPSHSSQ		molecular association, regulation	cell growth, altered	Shc1(DISRUPTS); HER2(DISRUPTS)		1339	3	1	1	Introduction of the S159A mutation markedly enhanced HRG-stimulated tyrosine phosphorylation of Gab2. A global amplification of HRG-induced tyrosine phosphorylation was observed in cells expressing S159A Gab2.	
tau iso8	Cytoskeletal protein	P10636-8	4137	MAPT	17q21.1	human	T245	PHOSPHORYLATION	487534	SAKSRLQtAPVPMPD	Tubulin-binding	molecular association, regulation				19084437	2	1	0	in vitro microtubule binding	
Kv1.2	Channel, potassium; Membrane protein, integral; Membrane protein, multi-pass	NP_001076191	100009479	LOC100009479		rabbit	S449	PHOSPHORYLATION	1818102	PDLKKSRsASTISKS		activity, induced				7543525	2	2	1		
BLM	DNA repair; DNA replication; EC 3.6.1.-; EC 3.6.4.12; Helicase	P54132	641	BLM	15q26.1	human	T122	PHOSPHORYLATION	450959	PKEVVCTtQNTPTVK		protein conformation	cell cycle regulation; apoptosis, inhibited			4650401; 3232; 8262	3	0	0	In cells expressing BLM T99A/T122A after HU release, entrance into G1 phase was delayed, with p-Chk-1 levels remaining  elevated. ; radiosensitivity	
Rb-like 1	Transcription, coactivator/corepressor; Tumor suppressor	P28749	5933	RBL1	20q11.2	human	S650	PHOSPHORYLATION	455534	SVHERYSsPTAGSAK		molecular association, regulation		E2F4(DISRUPTS)		5981	2	1	1		
claudin 7	Cell adhesion; Membrane protein, integral; Membrane protein, multi-pass	O95471	1366	CLDN7	17p13	human	S204	PHOSPHORYLATION	27732000	VPRSYPKsNSSKEYV			apoptosis, induced			27623401	1	0	0	increased sensitivity to cisplatin	
FosB	DNA binding protein; Transcription factor	P13346	14282	Fosb		mouse	S27	PHOSPHORYLATION	465535	SAESQYLsSVDSFGS		protein stabilization				13164216	4	0	0		
POLR2A	EC 2.7.7.48; EC 2.7.7.6; Nucleotide Metabolism - purine; Nucleotide Metabolism - pyrimidine; Transcription initiation complex; Transferase	P08775	20020	Polr2a		mouse	S1619	PHOSPHORYLATION	447616	SPSYSPTsPSYSPTS	RNA_pol_Rpb1_R	protein degradation; molecular association, regulation; ubiquitination; intracellular localization; enzymatic activity, induced	transcription, induced	TCEB3(INDUCES)		3394316; 21655803; 6702320; 3342609	58	0	0	low level transcription of bivalent genes 	
SHP-1	EC 3.1.3.48; Motility/polarity/chemotaxis; PHOSPHATASE; Protein phosphatase, tyrosine (non-receptor)	P29350	5777	PTPN6	12p13	human	Y536	PHOSPHORYLATION	448506	QKGQESEyGNITYPP		molecular association, regulation; enzymatic activity, induced		Grb2(INDUCES)		4254802; 3353; 2421	9	16	625		
ITGB3	Cell adhesion; Membrane protein, integral; Motility/polarity/chemotaxis	P05106	3690	ITGB3	17q21.32	human	Y773	PHOSPHORYLATION	448012	DTANNPLyKEATSTF	Integrin_b_cyt	activity, induced; molecular association, regulation; protein processing; activity, inhibited	cell motility, altered; cytoskeletal reorganization; cell adhesion, altered	Pyk2(INDUCES); Dok1(INDUCES); tensin 1(NOT_REPORTED); talin 1(DISRUPTS); PVR(DISRUPTS); VAV1(INDUCES); Grb2(INDUCES)		5188; 4750; 1839; 2512002; 1133; 3340206; 7075; 6113; 2848001; 4282202	17	7	100		
CRMP-2	Microtubule binding protein; Motility/polarity/chemotaxis	Q16555	1808	DPYSL2	8p22-p21	human	Y479	PHOSPHORYLATION	18833900	KPFPDFVyKRIKARS			cell motility, altered; cytoskeletal reorganization			7613727	1	0	0	regulates T cell polarization and migration	
PR	DNA binding protein; Nuclear receptor	P06401	5241	PGR	11q22-q23	human	S102	PHOSPHORYLATION	450158	GAGGSSSsPPEKDSG	Prog_receptor		transcription, induced			7324125	2	1	0		
TCF4	DNA binding protein; Transcription factor	P15884	6925	TCF4	18q21.1	human	S56	PHOSPHORYLATION	451216	NVEDRSSsGSWGNGG		molecular association, regulation	transcription, induced	desmoplakin 3(DISRUPTS)		3451	1	0	0		
G-alpha(q)	G protein; G protein, heterotrimeric; G protein, heterotrimeric alpha G(q)	P21279	14682	Gnaq		mouse	Y356	PHOSPHORYLATION	449722	LQLNLKEyNLV____	G-alpha	activity, induced		mAChR m1(NOT_REPORTED)		1359	2	0	0		
S6	Translation	P62754	20104	Rps6		mouse	S247	PHOSPHORYLATION	448096	STSKSESsQK_____			carcinogenesis, induced			27519661	4	12	297	Increased Kras induced pancreatic lesions, metaplastic foci, p53 expression	
Kv7.2	Channel, potassium; Membrane protein, integral; Membrane protein, multi-pass	O88943	170848	Kcnq2		rat	S541	PHOSPHORYLATION	11082901	SKRKFKEsLRPYDVM	KCNQ_channel	activity, induced				10296903	2	0	0	Mutants showed reduced currents induced by acetylcholine.	
Bim	Apoptosis	O54918	12125	Bcl2l11		mouse	S105	PHOSPHORYLATION	471329	DRSPAPMsCDKSTQT		protein degradation	apoptosis, inhibited			9090	1	0	0		
Grb10	Adaptor/scaffold	Q60760	14783	Grb10		mouse	S455	PHOSPHORYLATION	455333	NAPMRSVsENSLVAM	BPS	molecular association, regulation		14-3-3 eta(INDUCES)		4593	2	4	0		
NF1 iso2	GTPase activating protein, Ras; Motility/polarity/chemotaxis; Tumor suppressor	P21359-2	4763	NF1	17q11.2	human	S2576	PHOSPHORYLATION	456014	HPHLRKVsVSESNVL		molecular association, regulation; activity, inhibited		14-3-3 beta(INDUCES)		6580	1	9	10		
XBP1	DNA binding protein; Transcription factor	O35426	22433	Xbp1		mouse	T48	PHOSPHORYLATION	21688103	AGSEASGtPQARKRQ	CASP_C; Macoilin; GAS; ATG16; HOOK	intracellular localization				21683734	1	0	0	important for nuclear translocation of XBP1- not in obese (ob/ob) mice	
ITGB7	Cell adhesion; Membrane protein, integral; Motility/polarity/chemotaxis; Receptor, misc.	P26010	3695	ITGB7	12q13.13	human	T783	PHOSPHORYLATION	450186	PLYKSAItTTINPRF	Integrin_b_cyt	molecular association, regulation		FLNA(DISRUPTS)		7907	2	0	0	based on glutamate mutant of threonine site	
AS160	GTPase activating protein, Rab	O60343	9882	TBC1D4	13q22.2	human	T642	PHOSPHORYLATION	455921	QFRRRAHtFSHPPSS		molecular association, regulation		14-3-3 theta(INDUCES); 14-3-3 epsilon(INDUCES)		8164; 14058615	23	10	119	phosphorylation of this site has an effect on insulin-stimulated GLUT4 trafficking to the cell surface; multiple sites (6P) mutant	
leupaxin	Adaptor/scaffold; Cytoskeletal protein; Motility/polarity/chemotaxis	Q99N69	107321	Lpxn		mouse	Y72	PHOSPHORYLATION	449706	NIQEPNVySEVQEPK	Sigma70_r1_1	activity, induced				12073	2	1	44	important for laupaxin-mediated repression of BCR-induced IL-2 production	
PKCB	EC 2.7.11.13; KINASE; Kinase, protein; Motility/polarity/chemotaxis; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor)	P04410	25023	Prkcb		rat	T635	PHOSPHORYLATION	448592	SNFDKEFtRQPVELT	Pkinase_C	intracellular localization; enzymatic activity, induced	transcription, altered			9069	4	0	3	increases expression of c-Fos and c-Jun	
MEKK2	EC 2.7.11.25; KINASE; Kinase, protein; Protein kinase, STE; Protein kinase, Ser/Thr (non-receptor)	Q9Y2U5	10746	MAP3K2	2q14.3	human	T522	PHOSPHORYLATION	1904500	GTGMKSVtGTPYWMS	Pkinase	phosphorylation; enzymatic activity, induced	transcription, altered			1903001	1	1	0	Mutation of S520A inhibits activation and is the key residue.  Double mutation of T522A,T524A reduces activation effect.  T522A seems to have the least effect of the three single mutations.  The triple STT to AAA mutation is akin to kinase dead.  Activation leads to Erk5 and JNKK2 phosphorylation/activation.	
PTEN	Carbohydrate Metabolism - inositol phosphate; EC 3.1.3.16; EC 3.1.3.48; EC 3.1.3.67; Motility/polarity/chemotaxis; Nuclear receptor co-regulator; PHOSPHATASE; Phosphatase, lipid; Tumor suppressor	P60484	5728	PTEN	10q23.3	human	Y315	PHOSPHORYLATION	448317	RADNDKEyLVLTLTK	PTEN_C2	enzymatic activity, induced	cell growth, altered			1251	2	0	0		
NDRG1	Cell development/differentiation; Vesicle protein	Q92597	10397	NDRG1	8q24.3	human	S330	PHOSPHORYLATION	452879	LMRSRTAsGSSVTSL		phosphorylation	carcinogenesis, inhibited; carcinogenesis, altered			21683752; 14081211	6	33	454		
tau iso3	Cytoskeletal protein	P10636-3	4137	MAPT	17q21.1	human	S108	PHOSPHORYLATION	447928	SGYSSPGsPGTPGSR		molecular association, regulation	cytoskeletal reorganization			5955602	85	30	104	regulates association with membrane	
Ret	EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Protein kinase, TK; Protein kinase, tyrosine (receptor)	P07949	5979	RET	10q11.2	human	Y806	PHOSPHORYLATION	450700	PLLLIVEyAKYGSLR	Pkinase_Tyr	enzymatic activity, induced	cell growth, altered			3073	1	0	0		
CCR7	GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Motility/polarity/chemotaxis; Receptor, GPCR	P32248	1236	CCR7	17q12-q21.2	human	T372	PHOSPHORYLATION	455291	SMSVEAEtTTTFSP_		phosphorylation				4472	1	0	0	ERK1/2 phosphorylation	
FAK	EC 2.7.1.112; EC 2.7.10.2; KINASE; Kinase, protein; Protein kinase, TK; Protein kinase, tyrosine (non-receptor)	Q05397	5747	PTK2	8q24.3	human	Y194	PHOSPHORYLATION	18122800	ALEKKSNyEVLEKDV	FERM_M	protein conformation; phosphorylation; enzymatic activity, induced	cell motility, altered; cell growth, altered			18021000	2	2	1		
Met	EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Protein kinase, TK; Protein kinase, tyrosine (receptor)	P16056	17295	Met		mouse	Y1001	PHOSPHORYLATION	448469	VSNESVDyRATFPED		ubiquitination	cell motility, altered			4961500; 2849	9	15	316	inhibits cell motility	
ADD1	Cytoskeletal protein; Motility/polarity/chemotaxis	P35611	118	ADD1	4p16.3	human	S726	PHOSPHORYLATION	449829	KKKFRTPsFLKKSKK		intracellular localization	cytoskeletal reorganization			7097; 2346	16	27	153	Phosphorylation at T445 induced by STA2 translocated p-T445 into triton insoluble low speed fraction while p-S726 did not show any translocation of fractions.  This translocation was inhibited by Y27632.  	
RIP140	Nuclear receptor co-regulator; Transcription, coactivator/corepressor	Q8CBD1	268903	Nrip1		mouse	Y418	PHOSPHORYLATION	25234800	TPTTIDEySDNNPSF		protein degradation; ubiquitination				25227607	1	0	0	regulates inflamatory responses and contributes to endotoxin tolerance	
MAF1	Transcription regulation	Q9H063	84232	MAF1	8q24.3	human	T64	PHOSPHORYLATION	3211923	EALSPPQtSGLSPSR	Maf1		transcription, induced			12778829	1	3	1		
Abi-1	Adaptor/scaffold; Motility/polarity/chemotaxis	Q8IZP0	10006	ABI1	10p11.2	human	T265	PHOSPHORYLATION	18715504	GIPIAVPtPSPPTIG		molecular association, regulation	cell motility, altered; cytoskeletal reorganization			18668222	1	0	2	regulates WRC (WAVE2 regulatory complex) interaction with Arp2/3 and lamellipodial protrusion	
MARK1	EC 2.7.11.1; EC 2.7.11.26; KINASE; Kinase, protein; Protein kinase, CAMK; Protein kinase, Ser/Thr (non-receptor)	O08678	117016	Mark1		rat	T215	PHOSPHORYLATION	456037	TVGNKLDtFCGSPPY	Pkinase	enzymatic activity, induced				6889	2	24	28		
INCENP	Cell cycle regulation; EC 2.7.11.1	Q9NQS7	3619	INCENP	11q12.3	human	T59	PHOSPHORYLATION	458332	EPELMPKtPSQKNRR		intracellular localization	cell cycle regulation	KIF20A(DISRUPTS)		15675517; 7303914	5	1	18	as a part of chromosomal passenger protein complex (CPS); negatively regulates 	
PAR1	Cell development/differentiation; GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR	P25116	2149	F2R	5q13	human	S406	PHOSPHORYLATION	3627500	SSGQLMAsKMDTCSS		receptor desensitization, altered				4656	1	0	0	receptor shutoff (not internalization)	
TPT1	Calcium-binding protein; Microtubule binding protein	P63028	22070	Tpt1		mouse	S46	PHOSPHORYLATION	476067	TEGAIDDsLIGGNAS	TCTP	phosphorylation	cell cycle regulation; apoptosis, altered; cytoskeletal reorganization			3150500	1	7	8		
PU.1	DNA binding protein; Transcription factor	P17433	20375	Spi1		mouse	S132	PHOSPHORYLATION	478389	LSPAHQQsSDEEEGE		molecular association, regulation		IRF8(INDUCES); PU.1(INDUCES); IRF2(INDUCES)		9577	1	0	0	Interaction of PU.1, IRF-2, and IRF-8 requires phosphorylated residues on each protein. 	
ITGB5	Cell adhesion; Membrane protein, integral; Motility/polarity/chemotaxis	P18084	3693	ITGB5	3q21.2	human	S762	PHOSPHORYLATION	14694703	AKFQSERsRARYEMA	Integrin_b_cyt		cell motility, altered			14551414	1	0	0		
myelin P0	Adaptor/scaffold; Membrane protein, integral	P06907	24564	Mpz		rat	S233	PHOSPHORYLATION	458933	SRSTKAAsEKKSKGL	Protocadherin; IncA; Myelin-PO_C		cell adhesion, altered			11789	4	1	0		
survivin	Apoptosis	O70201	11799	Birc5		mouse	T34	PHOSPHORYLATION	447705	FLEDCACtPERMAEA	BIR		apoptosis, inhibited; cell growth, altered			6271024; 13245302	10	3	5		
TAL1	DNA binding protein; Transcription factor	P17542	6886	TAL1	1p32	human	S172	PHOSPHORYLATION	4704529	NRVKRRPsPYEMEIT		molecular association, regulation	transcription, induced	LSD1(DISRUPTS)		23260353	2	2	1		
doublecortin	Cytoskeletal protein; Motility/polarity/chemotaxis	O88809	13193	Dcx		mouse	S47	PHOSPHORYLATION	451112	TRTLQALsNEKKAKK		molecular association, regulation	cell motility, induced; cytoskeletal reorganization	TUBA1A(NOT_REPORTED); SPATA13(INDUCES)		23260307	3	0	0	Rac1 activation, lamellipodia formation	
ADRA2A	GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR	P08913	150	ADRA2A	10q25.2	human	S298	PHOSPHORYLATION	456351	LDLEESSsSDHAERP	7tm_1	activity, inhibited				6726	1	2	0		
PKR	EC 2.7.10.2; EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor); Translation	P19525	5610	EIF2AK2	2p22-p21	human	T88	PHOSPHORYLATION	3753308	AVSPLLLtTTNSSEG		enzymatic activity, induced				9075	1	0	0		
CKAP2	Cell cycle regulation	Q8WWK9	26586	CKAP2	13q14	human	T623	PHOSPHORYLATION	460436	FKELKFLtPVRRSRR		protein degradation	cell cycle regulation			7543500; 9689601	2	1	2		
CDK7	EC 2.7.11.22; EC 2.7.11.23; KINASE; Kinase, protein; Nuclear receptor co-regulator; Protein kinase, CMGC; Protein kinase, Ser/Thr (non-receptor)	Q03147	12572	Cdk7		mouse	S164	PHOSPHORYLATION	450041	GLAKSFGsPNRAYTH	Pkinase	enzymatic activity, induced				1664	3	23	18		
GRIP1	Adaptor/scaffold	P97879	84016	Grip1		rat	S917	PHOSPHORYLATION	471402	EATIMSGsTMSLNHE		phosphorylation				9108	1	0	0	Wild-type GRIP1 and mutant S19A there was a reduction in GluR2 surface expression, while S917 had no effect.   	
GPSM2	G protein regulator, misc.	P81274	29899	GPSM2	1p13.3	human	S408	PHOSPHORYLATION	4766076	PKLGRRHsMENMELM		molecular association, regulation; intracellular localization	cell cycle regulation	G-alpha2(i)(DISRUPTS)		17431515	2	12	9	stimulates binding to 14-3-3	
USP28	EC 3.1.2.15; EC 3.4.19.12; Protease; Ubiquitin-specific protease	Q96RU2	57646	USP28	11q23	human	S714	PHOSPHORYLATION	467253	ESSTNSSsQDYSTSQ			apoptosis, altered			8181	2	3	0		
ADD2	Cytoskeletal protein; Motility/polarity/chemotaxis	P35612	119	ADD2	2p13.3	human	S613	PHOSPHORYLATION	3147399	AKEAETKsPLVSPSK		phosphorylation	cell growth, induced; cytoskeletal reorganization			23940900	1	12	4		
SCN8A	Channel, sodium; Membrane protein, integral; Membrane protein, multi-pass	Q9WTU3	20273	Scn8a		mouse	S553	PHOSPHORYLATION	456209	SLLSIPGsPFLSRHN	DUF3451	molecular association, regulation; activity, inhibited		NEDD4L(INDUCES)		14743115	2	0	1		
Ret	EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Protein kinase, TK; Protein kinase, tyrosine (receptor)	P07949	5979	RET	10q11.2	human	Y900	PHOSPHORYLATION	450702	FGLSRDVyEEDSYVK	Pkinase_Tyr	enzymatic activity, induced				12482277; 3073	1	3	23		
ACP1	Cofactor and Vitamin Metabolism - riboflavin; EC 3.1.3.2; EC 3.1.3.48; Motility/polarity/chemotaxis; PHOSPHATASE; Phosphatase (non-protein); Protein phosphatase, tyrosine (non-receptor)	P24666	52	ACP1	2p25	human	Y132	PHOSPHORYLATION	450718	QLIIEDPyYGNDSDF	LMWPc	phosphorylation; enzymatic activity, induced	cell motility, altered; cell adhesion, altered; transcription, altered			8617; 5395700; 8616	5	10	194	regulates phosphorylation of p190Rho-GAP; dephosphorylation of RhoGAP, regulates ERK activation	
gp130	Membrane protein, integral; Receptor, cytokine	P40189	3572	IL6ST	5q11.2	human	Y767	PHOSPHORYLATION	450053	STVVHSGyRHQVPSV			cell cycle regulation; transcription, altered			1364	2	1	4		
CDCA5	Cell cycle regulation	Q96FF9	113130	CDCA5	11q12.1	human	T159	PHOSPHORYLATION	483401	LGSASTStPGRRSCF	Sororin	molecular association, regulation		PLK1(INDUCES)		21683719	3	5	15	stabilizes sister chromatid arm cohesion	
ZNF692	C2H2-type zinc finger protein; Transcription factor	Q9BU19	55657	ZNF692	1q44	human	S470	PHOSPHORYLATION	471395	VAAHRSKsHPALLLA			transcription, inhibited			9094	1	0	0	inhibits DNA binding and transcription	
NMDAR2C	Channel, calcium; Channel, ligand-gated; Membrane protein, integral; Membrane protein, multi-pass	Q00961	24411	Grin2c		rat	S1231	PHOSPHORYLATION	463822	SCTWRRVsSLESEV_		activity, induced				7842	1	0	0	regulates kinetics of ion channel	
TSC2 iso2	Cell cycle regulation; GTPase activating protein, misc.; Nuclear receptor co-regulator; Tumor suppressor	P49816-2	24855	Tsc2		rat	T1228	PHOSPHORYLATION	450211	PTLPRSNtVASFSSL		phosphorylation				2902	1	2	0	regulates p70S6K phosphorylation	
ER-alpha	DNA binding protein; Nuclear receptor	P03372	2099	ESR1	6q25.1	human	Y537	PHOSPHORYLATION	448103	CKNVVPLyDLLLEML	Hormone_recep	protein stabilization; molecular association, regulation	transcription, induced		DNA(INDUCES)	2625; 1074	6	0	0	Mutant Y537F has reduced stability bound to estradiol. 	
GABRG2 iso2	Channel, chloride; Channel, ligand-gated; Membrane protein, integral; Membrane protein, multi-pass	P22723-2	14406	Gabrg2		mouse	Y405	PHOSPHORYLATION	455818	ERDEEYGyECLDGKD	Neur_chan_memb	activity, induced				11468	7	0	0	potentiated GABA currents	
VAV3	Actin binding protein; Adaptor/scaffold; Guanine nucleotide exchange factor, Rac/Rho; Motility/polarity/chemotaxis; Nuclear receptor co-regulator	Q9UKW4	10451	VAV3	1p13.3	human	Y173	PHOSPHORYLATION	455605	EDEGGEVyEDLMKAE		activity, induced				6153	4	0	0		
CYLD	EC 3.1.2.15; EC 3.4.19.12; Protease; Ubiquitin conjugating system; Ubiquitin-specific protease	Q9NQC7	1540	CYLD	16q12.1	human	S422	PHOSPHORYLATION	4745563	RFHSLPFsLTKMPNT		ubiquitination				12156302	1	4	4	induces ubiquitination of TRAF2	
FAK iso5	EC 2.7.1.112; EC 2.7.10.2; KINASE; Kinase, protein; Protein kinase, TK; Protein kinase, tyrosine (non-receptor)	Q92063	396416	PTK2		chicken	S30	PHOSPHORYLATION	447962	PSRPGYPsPRSSEGF		molecular association, regulation		P130Cas(DISRUPTS)		1082	7	11	0		
p73	DNA binding protein; Transcription factor	O15350	7161	TP73	1p36.3	human	S388	PHOSPHORYLATION	6417400	VPQPLVDsYRQQQQL		activity, induced	cell cycle regulation; transcription, altered			6331316	1	0	0	regulates genes involved in cell cycle progression 	
TRPV6	Channel, calcium; Membrane protein, integral; Membrane protein, multi-pass	Q9R186	114246	Trpv6		rat	Y162	PHOSPHORYLATION	473578	RPHNLIYyGEHPLSF	Ank_2	activity, induced				9194	1	0	0	regulates calcium influx	
p27Kip1	Cell cycle regulation; Inhibitor protein; Protein kinase, regulatory subunit	P46527	1027	CDKN1B	12p13.1-p12	human	S10	PHOSPHORYLATION	447874	NVRVSNGsPSLERMD		protein degradation; molecular association, regulation; protein stabilization; intracellular localization; phosphorylation	cell cycle regulation; apoptosis, altered; cell motility, induced; cytoskeletal reorganization; cell adhesion, altered; transcription, altered	CTNNB1(DISRUPTS); exportin 1(INDUCES)		17827000; 1204; 11999201; 5654; 5459; 5992; 4214822; 6271; 5971; 6016; 1910500; 6038; 21690609; 2135	39	17	1		
securin	Cell cycle regulation	Q9CQJ7	30939	Pttg1		mouse	S162	PHOSPHORYLATION	452603	LLHLGPPsPLKTPFL	Securin	activity, induced; intracellular localization	transcription, altered			8761	1	24	2		
CTNNB1	Actin binding protein; Cell adhesion; Motility/polarity/chemotaxis; Nuclear receptor co-regulator; Transcription factor	Q02248	12387	Ctnnb1		mouse	S29	PHOSPHORYLATION	3075000	VSHWQQQsYLDSGIH		protein degradation; ubiquitination				4969204	3	1	4		
AFAP	Adaptor/scaffold	Q8N556	60312	AFAP1	4p16	human	S277	PHOSPHORYLATION	2853100	AELEKKLsSERPSSD			cytoskeletal reorganization			2831787	1	4	1		
PHOX2A	DNA binding protein; Transcription factor	O14813	401	PHOX2A	11q13.2	human	S208	PHOSPHORYLATION	9400301	ASPRLSPsPLPVALG		phosphorylation				9158113	1	1	0	regulates phosphorylation of PHOX2A S153	
EEA1	C2H2-type zinc finger protein; Vesicle protein	Q15075	8411	EEA1	12q22	human	T1392	PHOSPHORYLATION	456871	CSAKNALtPSSKKPV	IBR; FYVE	activity, induced; intracellular localization				6845	1	0	0	Phosphorylation required for efficient binding to endosome membranes.  Aspartate mutation can restore EEA1 fusion activity in the absence of p38a.	
ARHGAP22	GTPase activating protein, Rac/Rho	Q7Z5H3	58504	ARHGAP22	10q11.22	human	S395	PHOSPHORYLATION	4751993	LPAHRTSsLDGAAVA		molecular association, regulation	cell motility, induced	14-3-3 beta(INDUCES)		21683726	2	7	0		
PML iso4	Transcription factor; Tumor suppressor; Ubiquitin conjugating system	P29590-4	5371	PML	15q22	human	S36	PHOSPHORYLATION	451469	PSEGRQPsPSPSPTE		protein stabilization	apoptosis, altered			3657	2	7	0	Phosphorylation of PML is associated with enhanced sumoylation and apoptosis induced by As2O3. 	
VDR	DNA binding protein; Nuclear receptor; Transcription factor	P11473	7421	VDR	12q13.11	human	S51	PHOSPHORYLATION	451285	CKGFFRRsMKRKALF	zf-C4		transcription, induced			3509	2	0	0	Mutation of S51 inhibited transcriptional activation by the vitamin D hormone, suggesting that phosphorylation of S51 could play a role in vitamin D dependent transcriptional activation.	
ARAF	EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, Ser/Thr (non-receptor); Protein kinase, TKL	P10398	369	ARAF	Xp11.4-p11.2	human	S257	PHOSPHORYLATION	467474	SDGTPRGsPSPASVS		enzymatic activity, induced				3301229	2	12	49		
SGK1	EC 2.7.11.1; KINASE; Kinase, protein; Motility/polarity/chemotaxis; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor)	O00141	6446	SGK1	6q23	human	T369	PHOSPHORYLATION	448432	DLINKKItPPFNPNV		enzymatic activity, induced				1267	2	0	0		
hnRNP K	RNA binding protein; RNA splicing; Spliceosome	P61978	3190	HNRNPK	9q21.32-q21.33	human	Y225	PHOSPHORYLATION	456000	IKGRAQPyDPNFYDE	Phi-29_GP3		translation, altered			6566	1	1	1	based on Y72/225/230/234/236/380A mutant	
IL9R	Membrane protein, integral; Receptor, cytokine	Q01113	3581	IL9R	Xq28 and Yq12	human	T520	PHOSPHORYLATION	450657	LSKARSWtF______		molecular association, regulation		14-3-3 zeta(INDUCES)		3123	0	0	0		
ATR	EC 2.7.11.1; KINASE; Kinase, lipid; Kinase, protein; Membrane protein, integral; Protein kinase, ATYPICAL; Protein kinase, Ser/Thr (non-receptor)	Q13535	545	ATR	3q23	human	S428	PHOSPHORYLATION	456320	SSNSDGIsPKRRRLS		enzymatic activity, induced	cell growth, altered			1172819	8	6	1	growth of T47D cells is inhibited in the presence of THIF	
NCoA2	Motility/polarity/chemotaxis; Transcription, coactivator/corepressor	Q15596	10499	NCOA2	8q13.3	human	S493	PHOSPHORYLATION	468245	LSPRHRMsPGVAGSP			transcription, induced			22723912	1	19	0		
HOXA10	DNA binding protein; Transcription factor	P31260	3206	HOXA10	7p15.2	human	Y360	PHOSPHORYLATION	455551	KEFLFNMyLTRERRL	Homeobox	molecular association, regulation; activity, inhibited	transcription, induced	HOXA10(INDUCES)		5436	1	0	0	phosphorylation decreases Hox-A10 DNA binding affinity and transcriptional repression activity.	
PML	Transcription factor; Tumor suppressor; Ubiquitin conjugating system	P29590	5371	PML	15q22	human	S565	PHOSPHORYLATION	2479600	VISSSEDsDAENSSS	DUF3583	protein degradation	apoptosis, inhibited; cell growth, altered			2476704	3	5	0		
SPTLC1	EC 2.3.1.50; Lipid Metabolism - sphingolipid; Membrane protein, integral; Transferase	O15269	10558	SPTLC1	9q22.2	human	Y164	PHOSPHORYLATION	27930808	KTEEAIIySYGFATI	Aminotran_1_2	intracellular localization; enzymatic activity, inhibited	apoptosis, inhibited			27902364	1	0	0		
CRF-R1	GPCR, family 2; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR	P35353	58959	Crhr1		rat	S408	PHOSPHORYLATION	2859802	PTRVSFHsIKQSTAV		receptor desensitization, altered; receptor internalization, altered				2865400	1	3	2		
PDE11A	EC 3.1.4.17; EC 3.1.4.35; Mitochondrial; Nucleotide Metabolism - purine; Phosphodiesterase	Q9HCR9	50940	PDE11A	2q31.2	human	S162	PHOSPHORYLATION	2243100	RALLRKAsSLPPTTA		enzymatic activity, induced				2195466	1	3	0		
CD28	Cell surface; Membrane protein, integral	P31041	12487	Cd28		mouse	Y189	PHOSPHORYLATION	450282	NRLLQSDyMNMTPRR		molecular association, regulation		PIK3R1(INDUCES)		3934	5	4	314		
NR1I3	DNA binding protein; Nuclear receptor	O35627	12355	Nr1i3		mouse	S202	PHOSPHORYLATION	458347	LTMEDQIsLLKGAAV	Hormone_recep	intracellular localization				7362	1	0	1		
PDLIM2	Cell adhesion; UBIQUITIN LIGASE; Ubiquitin ligase	Q8R1G6	213019	Pdlim2		mouse	S137	PHOSPHORYLATION	4763817	PRPCSPFsTPPPTSP		ubiquitination; enzymatic activity, induced				15754908	1	6	26	PDLIM2 is STAT1 ubiquitin E3 ligase 	
Smad1	DNA binding protein; Transcription factor	Q15797	4086	SMAD1	4q31	human	S463	PHOSPHORYLATION	448362	SPHNPISsVS_____		activity, induced; molecular association, regulation; intracellular localization	transcription, altered	Smad4(INDUCES)		3385; 785	8	7	58		
PDHA2	Amino Acid Metabolism - valine, leucine and isoleucine biosynthesis; Carbohydrate Metabolism - butanoate; Carbohydrate Metabolism - citrate (TCA) cycle; Carbohydrate Metabolism - glycolysis and gluconeogenesis; Carbohydrate Metabolism - pyruvate; EC 1.2.4.1; Mitochondrial; Oxidoreductase	P29803	5161	PDHA2	4q22-q23	human	S291	PHOSPHORYLATION	458869	TYRYHGHsMSDPGVS	E1_dh	enzymatic activity, induced				7455	1	29	605		
EB3	Microtubule binding protein	Q9UPY8	22924	MAPRE3	2p23.3-p23.1	human	S176	PHOSPHORYLATION	4740060	MQTSGRLsNVAPPCI		protein stabilization; molecular association, regulation; ubiquitination	cell cycle regulation	SIAH1(DISRUPTS)		10353915	2	2	0		
RFC1	DNA replication	D3ZFT1	89809	Rfc1		rat	S361	PHOSPHORYLATION	3136107	GSPTKREsVSPEDSE			transcription, induced			8890	1	5	0		
P2RY4	GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR	P51582	5030	P2RY4	Xq13	human	S334	PHOSPHORYLATION	10349701	QPRTAASsLALVSLP		receptor desensitization, altered; receptor internalization, altered				10144228	1	0	0		
FAK iso3	EC 2.7.1.112; EC 2.7.10.2; KINASE; Kinase, protein; Protein kinase, TK; Protein kinase, tyrosine (non-receptor)	P34152-3	14083	Ptk2		mouse	Y925	PHOSPHORYLATION	447966	DRSNDKVyENVTGLV	Focal_AT	molecular association, regulation; phosphorylation	transcription, altered; cell growth, altered	Grb2(INDUCES)		3256103; 2316; 673; 3256104; 2877; 2871	70	10	434	MMP-9 production;  increases tumor size; ERK phosphorylation/activation	
myocardin	Cell development/differentiation; Transcription factor	Q8VIM5	214384	Myocd		mouse	S632	PHOSPHORYLATION	3627509	TFLSPQCsPQHSPLG			transcription, inhibited			6856	1	0	0		
SPRY2	Adaptor/scaffold; Inhibitor protein; Motility/polarity/chemotaxis	O43597	10253	SPRY2	13q31.1	human	Y55	PHOSPHORYLATION	448849	AIRNTNEyTEGPTVV		activity, induced; protein degradation; molecular association, regulation; activity, inhibited; phosphorylation	cell differentiation, altered; transcription, altered	Cbl(INDUCES); Grb2(INDUCES)		5748; 4413; 7159; 8112; 6643; 5816; 9248	10	5	87		
LIME1	Adaptor/scaffold; Membrane protein, integral	Q9H400	54923	LIME1	20q13.3	human	Y200	PHOSPHORYLATION	454607	AAQVDVLySRVCKPK		molecular association, regulation		CSK(INDUCES)		12482278	1	4	87		
SYTL1		Q8IYJ3	84958	SYTL1	1p36.11	human	S241	PHOSPHORYLATION	456480	RMLSSSSsVSSLNSS		intracellular localization		RAB27A(NOT_REPORTED)		6699	1	0	0		
KCNMA1	Channel, potassium; Endoplasmic reticulum; Membrane protein, integral; Membrane protein, multi-pass	Q28204	282573	KCNMA1		cow	S1151	PHOSPHORYLATION	14364501	NRQNRPKsRESRDKQ		activity, inhibited				14058611	1	0	0		
CK1E	EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, CK1; Protein kinase, Ser/Thr (non-receptor)	P49674	1454	CSNK1E	22q13.1	human	S368	PHOSPHORYLATION	449793	NTSPRAIsRVDRERK		enzymatic activity, inhibited				8419; 2331	2	0	0	some subset of these 8 sites	
DAB1	Adaptor/scaffold	Q8CJH2	266729	Dab1		rat	S400	PHOSPHORYLATION	479417	TNDSARSsPQSDKPR		molecular association, regulation		CIN85(DISRUPTS); CD2AP(DISRUPTS)		1713130	3	0	0		
KOR-1	GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR	P34975	29335	Oprk1		rat	S369	PHOSPHORYLATION	449609	NTVQDPAsMRDVGGM		receptor desensitization, altered; receptor internalization, altered				2250	7	0	0		
ETV1	DNA binding protein; Transcription factor	P50549	2115	ETV1	7p21.3	human	T143	PHOSPHORYLATION	3059604	NPPTPSStPVSPLHH	ETS_PEA3_N	activity, induced	transcription, induced			8495	2	0	0		
SPRY2	Adaptor/scaffold; Inhibitor protein; Motility/polarity/chemotaxis	O43597	10253	SPRY2	13q31.1	human	T75	PHOSPHORYLATION	4145505	KPAPRPStQHKHERL		activity, inhibited				4042507	2	0	0		
Srcasm	Adaptor/scaffold	Q923U0	71943	Tom1l1		mouse	Y392	PHOSPHORYLATION	451208	NLASSHTyDNFHSNS		molecular association, regulation		Grb2(INDUCES)		3437	2	0	1		
ELK1	DNA binding protein; Transcription factor	P19419	2002	ELK1	Xp11.2	human	S324	PHOSPHORYLATION	471887	RDLELPLsPSLLGGP		activity, induced; protein conformation	transcription, induced			2270	2	3	9		
TAX1BP1 iso2	Apoptosis	Q86VP1-2	8887	TAX1BP1	7p15	human	S624	PHOSPHORYLATION	468908	RPPVRVPsWGLEDNV		molecular association, regulation; ubiquitination	signaling pathway regulation	TRAF2(INDUCES); TRAF6(INDUCES)		20722937	1	11	105	regulates NF-kB signaling;  ;  regulates interaction with A20 and Itch via TRAF2 and TRAF6	
PIAS1	EC 6.3.2.-; Nuclear receptor co-regulator; SUMO LIGASE; SUMO conjugating system; Transcription, coactivator/corepressor	O75925	8554	PIAS1	15q	human	S522	PHOSPHORYLATION	3177709	DTSYINTsLIQDYRH		sumoylation; enzymatic activity, induced	transcription, inhibited			27257060	1	1	0	 ; PIAS1 S522A expression inhibits TNF-induced sumoylation of p53;  inhibits inflammatory genes expression	
CDKN2D	Cell cycle regulation; Inhibitor protein	P55273	1032	CDKN2D	19p13	human	T141	PHOSPHORYLATION	25256101	RRDARGLtPLELALQ	Ank_2	phosphorylation	cell cycle regulation; cell growth, induced			25227666	1	1	0	S76/T141 phosphorylation is necessary for CDKN2D function in DNA repair.; S76 is phosphorylated first, followed by T141 phosphorylation.	
FBXW7	Motility/polarity/chemotaxis; UBIQUITIN LIGASE; Ubiquitin conjugating system	Q969H0	55294	FBXW7	4q31.3	human	T205	PHOSPHORYLATION	25585000	GLVPCSAtPTTFGDL	Nop14	protein degradation; molecular association, regulation; ubiquitination	carcinogenesis, induced; cell growth, induced	Pin1(INDUCES)		25573517	1	0	0	Pin1 disrupts FBXW7 dimerization.  	
PPP1CC	EC 3.1.3.16; Motility/polarity/chemotaxis; PHOSPHATASE; Protein phosphatase, Ser/Thr (non-receptor)	P36873	5501	PPP1CC	12q24.1-q24.2	human	T318	PHOSPHORYLATION	11379600	TPPRGMItKQAKK__		enzymatic activity, inhibited				10296915	1	1	0	in vitro	
TAB1	Activator protein; Motility/polarity/chemotaxis	Q15750	10454	TAB1	22q13.1	human	S438	PHOSPHORYLATION	456224	TPTLTNQsPTLTLQS		phosphorylation				7549215	6	0	0	inhibits TAK1 T187 phosphorylation	
PKCD	EC 2.7.10.2; EC 2.7.11.13; KINASE; Kinase, protein; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor)	P09215	170538	Prkcd		rat	Y512	PHOSPHORYLATION	450078	TFCGTPDyIAPEILQ	Pkinase	enzymatic activity, induced				1244	2	3	0		
RHOT1	EC 3.6.5.-; G protein; G protein, monomeric, Rho; Hydrolase; Membrane protein, integral; Mitochondrial	Q8IXI2	55288	RHOT1	17q11.2	human	S156	PHOSPHORYLATION	21587701	AKNLKNIsELFYYAQ	Ras	protein degradation				21589900	2	1	0	arrest of mitochondrial motility	
ERR3	DNA binding protein; Nuclear receptor; Transcription factor	P62508	2104	ESRRG	1q41	human	K40	SUMOYLATION	6048402	SSCSSFIkTEPSSPA			transcription, inhibited			5930024	1	0	0		
GSTA4	EC 2.5.1.18; Other Amino Acids Metabolism - glutathione; Transferase; Xenobiotic Metabolism - drug metabolism - cytochrome P450; Xenobiotic Metabolism - metabolism by cytochrome P450	O15217	2941	GSTA4	6p12.1	human	T193	PHOSPHORYLATION	455667	VKLSNIPtIKRFLEP		molecular association, regulation; intracellular localization		HSP70(INDUCES)		5706	1	0	0		
PML	Transcription factor; Tumor suppressor; Ubiquitin conjugating system	P29590	5371	PML	15q22	human	T409	PHOSPHORYLATION	469197	ASPEAAStPRDPIDV	DUF3583		carcinogenesis, altered			15675501	1	1	24		
ADRB2	GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR	P04274	101836719	Adrb2		hamster	S262	PHOSPHORYLATION	447909	GHGLRRSsKFCLKEH	7tm_1	receptor desensitization, altered				1641	9	0	1	S262 was primary site of cAPK desensitization, while either 261 or 262 for PKC desensitization, as well as ADRB2 expression level. 	
AR	DNA binding protein; Nuclear receptor; Transcription factor	P10275	367	AR	Xq12	human	Y534	PHOSPHORYLATION	470068	MDSYSGPyGDMRLET		intracellular localization	cell cycle regulation; transcription, altered			8969	2	1	0	Location affected under androgen-depleted conditions	
NAC1	Transcription factor	O35260	171454	Nacc1		rat	S245	PHOSPHORYLATION	457535	CVSGPSMsERTSPGT		intracellular localization				7119	1	0	0		
MSK1	EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor)	O75582	9252	RPS6KA5	14q31-q32.1	human	T581	PHOSPHORYLATION	448217	PDNQPLKtPCFTLHY	Pkinase	intracellular localization; enzymatic activity, induced	cytoskeletal reorganization			5121514; 11463; 12023002; 6119	12	1	0	correlated with nuclear infolding; regulation of enzymatic activation of MSK1 translocation to  caceolin-3 enriched membrane fraction	
CACNG2	Channel, calcium; Membrane protein, integral; Membrane protein, multi-pass	O88602	12300	Cacng2		mouse	S237	PHOSPHORYLATION	455314	RYRYQRRsRSSSRST	Tetraspannin	activity, induced; intracellular localization				22913905; 4485	1	0	0	AMPAR immobilization in synaptic membrane; enhances AMPA receptor responses and is required for long-term potentiation	
GUCY1A3	EC 4.6.1.2; Guanylyl cyclase; Lyase; Nucleotide Metabolism - purine; Receptor, misc.	Q8CJD2	497757	Gucy1a3		rat	S108	PHOSPHORYLATION	450955	IKENRNSsEKEDLER	HNOB	enzymatic activity, induced				3227	1	0	0		
CFTR	Channel, chloride; EC 3.6.3.49; Hydrolase; Membrane protein, integral; Membrane protein, multi-pass; Transporter	P26361	12638	Cftr		mouse	S660	PHOSPHORYLATION	449979	FTEERRSsILTETLR	CFTR_R	protein conformation				11424200	5	5	0	in vitro	
InsR	EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Protein kinase, TK; Protein kinase, tyrosine (receptor)	P06213	3643	INSR	19p13.3-p13.2	human	Y1361	PHOSPHORYLATION	447684	SYEEHIPyTHMNGGK		protein conformation; enzymatic activity, induced	cell cycle regulation; cell growth, altered			3856; 4048; 2653; 8589	14	5	13	antibodies against  Y1355 and Y1361 peptides stimulated cell proliferation.  ; autophosphorylation; decreases ERK activation	
Cbl	Adaptor/scaffold; EC 6.3.2.-; EC 6.3.2.19; Ligase; Motility/polarity/chemotaxis; UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase	P22681	867	CBL	11q23.3	human	S642	PHOSPHORYLATION	4704608	PRLGSTFsLDTSMSM		molecular association, regulation		14-3-3 eta(INDUCES)		10144203	0	2	7		
NDEL1	Microtubule binding protein; Protease	Q9ERR1	83431	Ndel1		mouse	T219	PHOSPHORYLATION	468252	ASLSLPAtPVGKGTE	NUDE_C	activity, induced; intracellular localization	cell motility, altered			2425202	3	10	3	Cdc42 activation	
MafA	DNA binding protein; Transcription factor	Q8CF90	378435	Mafa		mouse	T57	PHOSPHORYLATION	456028	LSSTPLStPCSSVPS		molecular association, regulation		MafA(INDUCES)	DNA(NOT_REPORTED)	13326312	6	1	0		
HER2	EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Protein kinase, TK; Protein kinase, tyrosine (receptor)	P04626	2064	ERBB2	17q12	human	Y1248	PHOSPHORYLATION	447614	PTAENPEyLGLDVPV		activity, induced; molecular association, regulation; intracellular localization; phosphorylation	cell motility, altered; cytoskeletal reorganization; transcription, induced; signaling pathway regulation	CPNE3(INDUCES); Shc1(INDUCES); RACK1(INDUCES)		2852654; 5399; 4215300; 4835212; 14148615	41	7	174		
TRPV5	Channel, cation; Membrane protein, integral; Membrane protein, multi-pass; Motility/polarity/chemotaxis	Q9NQA5	56302	TRPV5	7q35	human	S654	PHOSPHORYLATION	470109	YVEVFKNsDKEDDQE		activity, induced; intracellular localization				8913	3	0	0		
Cx43	Channel, misc.; Membrane protein, integral; Membrane protein, multi-pass; Motility/polarity/chemotaxis	P08050	24392	Gja1		rat	S328	PHOSPHORYLATION	449993	GQAGSTIsNSHAQPF		intracellular localization	cell adhesion, altered			2541	7	9	0		
KCNMA1	Channel, potassium; Endoplasmic reticulum; Membrane protein, integral; Membrane protein, multi-pass	Q28204	282573	KCNMA1		cow	T139	PHOSPHORYLATION	469977	PVDEKEEtVAAEVGW		activity, induced				8815	1	0	0	CAMK2 phosphorylation switches ethanol induced activation of channel to inhibition.  	
PXR	DNA binding protein; Nuclear receptor	O75469	8856	NR1I2	3q12-q13.3	human	S350	PHOSPHORYLATION	4668103	MQAISLFsPDRPGVL	Hormone_recep	molecular association, regulation; activity, inhibited	transcription, altered	N-CoR1(DISRUPTS); Fgr(INDUCES); RXRA(DISRUPTS)		4641416; 9689411	4	0	0	inhibits transcription	
MEF2C	DNA binding protein; Transcription factor	Q06413	4208	MEF2C	5q14.3	human	K391	SUMOYLATION	7533202	STQSLNIkSEPVSPP			transcription, inhibited			7645	1	0	0		
cofilin 1	Cytoskeletal protein; Motility/polarity/chemotaxis	P23528	1072	CFL1	11q13	human	S3	PHOSPHORYLATION	448444	_____MAsGVAVSDG		activity, induced; molecular association, regulation; intracellular localization; activity, inhibited; phosphorylation	cell cycle regulation; apoptosis, inhibited; cell motility, altered; cell adhesion, altered; cytoskeletal reorganization	14-3-3 zeta(INDUCES)		6390; 14148613; 7981805; 2661901; 6328011; 6011109; 4214816; 1713125; 6329; 4862600; 21588901; 4862601; 7313804; 647; 4557	52	32	2	G2/M arrest	
ROMK	Channel, potassium; Membrane protein, integral; Membrane protein, multi-pass	P48048	3758	KCNJ1	11q24	human	S183	PHOSPHORYLATION	2813506	GAILAKIsRPKKRAK	IRK	activity, induced; intracellular localization				8783	2	0	0		
ULK1	Autophagy; EC 2.7.1.37; EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor)	O70405	22241	Ulk1		mouse	T574	PHOSPHORYLATION	17741300	PKLPKPPtDPLGATF			autophagy, altered			17740400	0	1	6		
UHRF1	DNA binding protein; EC 6.3.2.-; EC 6.3.2.19; Ligase; Transcription factor; UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase	Q96T88	29128	UHRF1	19p13.3	human	S661	PHOSPHORYLATION	469962	GGPSRAGsPRRTSKK		intracellular localization				22463913	1	6	0	essential for pre-gastrula development in zebrafish	
RPS5	Ribosomal protein; Translation	P97461	20103	Rps5		mouse	T133	PHOSPHORYLATION	9819905	TRIGRAGtVRRQAVD	Ribosomal_S7	intracellular localization; phosphorylation				9721212	1	1	0	triggers phosphorylation of S23	
HSP27	Chaperone; Motility/polarity/chemotaxis	Q00649		HSPB1		chicken	S81	PHOSPHORYLATION	452224	RALSELSsGISEIRQ	Cupredoxin_1	protein conformation				8559	0	11	17	Mutations mimicking phosphorylation of sites single (S15D) and in combination  form high and low molecular oligomers and affect chaperone activity in vitro. 	
HDAC5	EC 3.5.1.98; Hydrolase	Q9Z2V6	15184	Hdac5		mouse	S250	PHOSPHORYLATION	447995	FPLRKTAsEPNLKVR		molecular association, regulation		14-3-3 epsilon(INDUCES)		1117	16	9	17		
lamin A/C	Cytoskeletal protein	P48679	60374	Lmna		rat	S404	PHOSPHORYLATION	478681	RSRGRASsHSSQSQG		activity, induced				4651309	3	19	97	nucleus morphology	
IGF1R	EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Protein kinase, TK; Protein kinase, tyrosine (receptor)	P08069	3480	IGF1R	15q26.3	human	Y1166	PHOSPHORYLATION	448388	DIYETDYyRKGGKGL	Pkinase_Tyr	protein conformation; phosphorylation; enzymatic activity, induced	cell growth, altered			2407108; 2705; 7397608; 4783	9	11	108	in vitro; 
	
MCM4	DNA replication; EC 3.6.4.12	P33991	4173	MCM4	8q11.2	human	T19	PHOSPHORYLATION	448634	GSRRGRAtPAQTPRS		activity, inhibited				2551	3	13	8		
C5aR	GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR	P21730	728	C5AR1	19q13.3-q13.4	human	S317	PHOSPHORYLATION	450056	RLRKSLPsLLRNVLT		molecular association, regulation		ARRB1(INDUCES); ARRB2(INDUCES)		1994	2	0	0		
eIF4E	Translation; Translation initiation	P06730	1977	EIF4E	4q21-q25	human	S209	PHOSPHORYLATION	447776	DTATKSGsTTKNRFV			cell growth, altered		RNA(DISRUPTS)	7324113; 1969103	42	1	0	S209A/T210A mutant showed reduced transport of cyclin D1 mRNA from nucleus to cytoplasm.  eiF4E cellular distribution not affected by phosphorylation. 	
Nik	EC 2.7.11.25; KINASE; Kinase, protein; Protein kinase, STE; Protein kinase, Ser/Thr (non-receptor)	Q99558	9020	MAP3K14	17q21	human	T559	PHOSPHORYLATION	455390	TGDYIPGtETHMAPE	Pkinase	enzymatic activity, induced	transcription, altered			4009	2	0	0		
GRASP55	Motility/polarity/chemotaxis; Vesicle protein	Q9R064	113961	Gorasp2		rat	T249	PHOSPHORYLATION	2756300	PSLSPPGtAGVEQSL			cell cycle regulation			2725506	2	0	1		
InsR iso2	EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Protein kinase, TK; Protein kinase, tyrosine (receptor)	P06213-2	3643	INSR	19p13.3-p13.2	human	Y987	PHOSPHORYLATION	447685	YASSNPEyLSASDVF		activity, induced				1123	21	0	0	mutation of site impairs insulin stimulation of PI3K activity.	
NDR2	EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor)	Q9Y2H1	23012	STK38L	12p11.23	human	T75	PHOSPHORYLATION	460299	SQHARKEtEFLRLKR		molecular association, regulation; enzymatic activity, induced	cell growth, altered	S100B(INDUCES)		7692; 3334	2	0	0		
rictor	Adaptor/scaffold; Cell cycle regulation; Ubiquitin conjugating system	Q6R327	253260	RICTOR	5p13.1	human	T1135	PHOSPHORYLATION	458276	NRRIRTLtEPSVDFN		molecular association, regulation; ubiquitination; phosphorylation		14-3-3 beta(INDUCES); 14-3-3 epsilon(INDUCES); CUL1(DISRUPTS)		25608304; 17799700; 11387250; 12025502	7	6	170	ILK/Rictor complex formation in cancer but not in normal cell types; T1135 phosphorylation reduces Rictor ubiquitination of SGK1.	
TNF-R2	Membrane protein, integral; Receptor, cytokine	P20333	7133	TNFRSF1B	1p36.22	human	T436	PHOSPHORYLATION	11493000	AFRSQLEtPETLLGS		activity, inhibited				10303905	1	0	0	may inhibit activation of NF-kB.	
Chk1	EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, CAMK; Protein kinase, Ser/Thr (non-receptor)	O35280	12649	Chek1		mouse	S317	PHOSPHORYLATION	447833	ETVKFSSsQPEPRTG		intracellular localization	cell cycle regulation			1173031	52	6	5		
p70S6K	EC 2.7.11.-; EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor); Translation	P67999	83840	Rps6kb1		rat	T444	PHOSPHORYLATION	448358	RFIGSPRtPVSPVKF		enzymatic activity, induced				6139; 5011214	94	16	84	Quadruple mutant was 20% protected  from inactivation by glucocorticoids. 	
PDGFRB	EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Protein kinase, TK; Protein kinase, tyrosine (receptor)	P09619	5159	PDGFRB	5q33.1	human	Y775	PHOSPHORYLATION	449964	SSNYMAPyDNYVPSA	Pkinase_Tyr	molecular association, regulation		GRB7(INDUCES)		2523	3	1	2		
p53	Activator protein; DNA binding protein; Motility/polarity/chemotaxis; Nuclear receptor co-regulator; Transcription factor; Tumor suppressor	P04637	7157	TP53	17p13.1	human	K120	UBIQUITINATION	486293	FLHSGTAkSVTCTYS	DEC-1_N; P53	protein degradation; intracellular localization				12136	1	1	18		
NME1	EC 2.7.4.6; KINASE; Kinase, nucleoside diphosphate; Kinase, other; Nucleotide Metabolism - purine; Nucleotide Metabolism - pyrimidine; Tumor suppressor	P15531	4830	NME1	17q21.3	human	S120	PHOSPHORYLATION	450098	GRNIIHGsDSVESAE	NDK	molecular association, regulation; protein conformation; enzymatic activity, induced	cell growth, altered	PRUNE(INDUCES)		2700; 9183; 2918; 7991121	6	8	0	inhibits colony formation in soft agar	
ARNT	DNA binding protein; Motility/polarity/chemotaxis; Nuclear receptor; Transcription factor	P27540	405	ARNT	1q21	human	S77	PHOSPHORYLATION	458309	DKERFARsDDEQSSA		activity, inhibited	transcription, inhibited			7372	1	9	6		
DGKG	EC 2.7.1.107; Kinase, lipid; Lipid Metabolism - glycerolipid; Lipid Metabolism - glycerophospholipid; Motility/polarity/chemotaxis	P49620	25666	Dgkg		rat	S776	PHOSPHORYLATION	471077	MGPPQKSsFFSLRRK		enzymatic activity, induced				9013	1	0	0		
DYN2	EC 3.6.5.5; Hydrolase; Microtubule binding protein; Motility/polarity/chemotaxis; Vesicle protein	P50570	1785	DNM2	19p13.2	human	T766	PHOSPHORYLATION	452323	SASSHSPtPQRRPVS		molecular association, regulation				15562515	1	3	0	reduces microtubule-binding activity of DYN2 	
ARHGAP24	GTPase activating protein, Rac/Rho; Motility/polarity/chemotaxis	Q8N264	83478	ARHGAP24	4q22.1	human	S402	PHOSPHORYLATION	4757006	LSGSKTNsPKNSVHK		activity, induced	cytoskeletal reorganization			12482285	1	4	0	membrane blebbing	
Rin1	Guanine nucleotide exchange factor, Rab	Q921Q7	225870	Rin1		mouse	Y147	PHOSPHORYLATION	2796500	LVQLICGyCRTRAIH	SH2	molecular association, regulation		Arg(INDUCES)		6201	1	0	0		
SPRY2	Adaptor/scaffold; Inhibitor protein; Motility/polarity/chemotaxis	Q9QXV8	24064	Spry2		mouse	Y55	PHOSPHORYLATION	448849	AIRNTNEyTEGPTVV		activity, induced; molecular association, regulation; activity, inhibited		Cbl(INDUCES); Grb2(INDUCES)		3406; 2022	10	5	87		
JAK3	EC 2.7.10.2; KINASE; Kinase, protein; Protein kinase, TK; Protein kinase, tyrosine (non-receptor)	P52333	3718	JAK3	19p13.1	human	Y981	PHOSPHORYLATION	447637	LPLDKDYyVVREPGQ	Pkinase_Tyr	enzymatic activity, inhibited				1142	2	3	1		
FLT3	EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Protein kinase, TK; Protein kinase, tyrosine (receptor)	P36888	2322	FLT3	13q12	human	Y589	PHOSPHORYLATION	448189	TGSSDNEyFYVDFRE		molecular association, regulation; enzymatic activity, inhibited; phosphorylation	cell growth, altered	Src(INDUCES)		1992301; 2594; 8124	6	0	1	The double mutation Y589/591F has a slower growth rate (this is in the ligand-independent, constitutive active allele).; While none of the single mutations affected STAT-5 phosphotyrosine levels, 3 double mutations did:  Y591/726F, Y591/955F, Y589/591F (all three pairs have Y591F in common).	
GATA6	Motility/polarity/chemotaxis; Transcription factor	Q92908	2627	GATA6	18q11.1-q11.2	human	S266	PHOSPHORYLATION	2833503	VSARFPYsPSPPMAN	GATA-N		transcription, induced; cell growth, altered			2831769	1	1	3		
ITGB1	Cell adhesion; Cell surface; Membrane protein, integral; Motility/polarity/chemotaxis; Receptor, misc.	P05556	3688	ITGB1	10p11.2	human	Y783	PHOSPHORYLATION	447710	DTGENPIyKSAVTTV	Integrin_b_cyt	molecular association, regulation		tensin 1(NOT_REPORTED)		2848001	5	24	1162	phosphorylation does not seem to affect tensin binding;  however, in vivo, tensin competes with talin which prefers non-phosphorylated sites	
desmoplakin	Cell adhesion; Cytoskeletal protein; Motility/polarity/chemotaxis	P15924	1832	DSP	6p24	human	S2849	PHOSPHORYLATION	451165	RSGSRRGsFDATGNS		molecular association, regulation				3362	1	1	0	Desmoplakin S2849 phosphorylation may negatively regulate its interaction with the networks of keratin intermediate filaments. 	
SRC-3	ACETYLTRANSFERASE; Acetyltransferase; EC 2.3.1.48; Motility/polarity/chemotaxis; Nuclear receptor co-regulator; Transcription, coactivator/corepressor	Q9Y6Q9	8202	NCOA3	20q12	human	S1048	PHOSPHORYLATION	4252803	PSNLEGQsDERALLD	Nuc_rec_co-act	protein stabilization; molecular association, regulation		PSMA3(DISRUPTS)		4248206	1	0	0	some subset of these 8 residues	
LRP2	Membrane protein, integral; Motility/polarity/chemotaxis; Receptor, misc.	P98164	4036	LRP2	2q31.1	human	S4616	PHOSPHORYLATION	767904	VAATPPPsPSLPAKP		receptor internalization, altered; receptor recycling, altered				762703	1	4	0		
NF1 iso2	GTPase activating protein, Ras; Motility/polarity/chemotaxis; Tumor suppressor	P21359-2	4763	NF1	17q11.2	human	S2580	PHOSPHORYLATION	456017	RKVSVSEsNVLLDEE		molecular association, regulation; activity, inhibited		14-3-3 beta(INDUCES)		6580	1	2	0		
ARAF	EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, Ser/Thr (non-receptor); Protein kinase, TKL	P10398	369	ARAF	Xp11.4-p11.2	human	S582	PHOSPHORYLATION	481007	PKIERSAsEPSLHRT		enzymatic activity, induced				3301229	1	33	8		
NCBP1	RNA processing; Spliceosome; Translation	Q09161	4686	NCBP1	9q34.1	human	T21	PHOSPHORYLATION	480103	QPHKRRKtSDANETE			RNA splicing, altered			12482263	1	11	68		
VEGFR1	EC 2.7.1.112; EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Protein kinase, TK; Protein kinase, tyrosine (receptor)	P17948	2321	FLT1	13q12	human	Y1242	PHOSPHORYLATION	448210	ATSMFDDyQGDSSTL			cell cycle regulation; cell growth, altered			1403	2	1	2	mutation to phenylalanine caused increased tyrosine phosphorylation of PLCG1	
C/EBP-beta	DNA binding protein; Motility/polarity/chemotaxis; Transcription factor	P21272	24253	Cebpb		rat	S105	PHOSPHORYLATION	448425	AKPSKKPsDYGYVSL		molecular association, regulation	cell cycle regulation; cell growth, altered	Casp8(INDUCES); Casp1(INDUCES)		6452; 618	5	0	0		
AVPR2	GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR	P30518	554	AVPR2	Xq28	human	S363	PHOSPHORYLATION	451068	ESCTTASsSLAKDTS		intracellular localization; receptor recycling, altered				3288; 8879	2	0	0		
tau	Cytoskeletal protein	P19332	29477	Mapt		rat	S573	PHOSPHORYLATION	447930	NVRSKIGsTENLKHQ	Tubulin-binding		cytoskeletal reorganization			4214826	68	8	2		
ARPP-21	Inhibitor protein	Q9DCB4	74100	Arpp21		mouse	S55	PHOSPHORYLATION	1096600	QNQERRKsKSGAGKG		molecular association, regulation	signaling pathway regulation	calmodulin(INDUCES)		12482430	2	0	0	Regulates PP2B suppression and PKA activation of calcium currents.	
TBL1XR1	Nuclear receptor co-regulator; Transcription, coactivator/corepressor	Q9BZK7	79718	TBL1XR1	3q26.32	human	S199	PHOSPHORYLATION	2509603	TARIWNLsENSTSGS			transcription, induced			2425230	1	0	0		
PDHK1	EC 2.7.11.2; KINASE; Kinase, protein; Mitochondrial; Protein kinase, ATYPICAL; Protein kinase, atypical	Q15118	5163	PDK1	2q31.1	human	Y243	PHOSPHORYLATION	462384	ARRLCDLyYINSPEL		intracellular localization				25220606	1	0	2	localized to mitochondria in cancer cells	
p47phox	EC 1.-.-.-; Oxidoreductase	P14598	653361	NCF1	7q11.23	human	S303	PHOSPHORYLATION	449405	RGAPPRRsSIRNAHS		activity, induced; molecular association, regulation; enzymatic activity, induced		CYBA(INDUCES)		2208; 8704	5	0	0		
BLNK	Adaptor/scaffold	Q8WV28	29760	BLNK	10q23.2-q23.33	human	Y72	PHOSPHORYLATION	447718	SDDFDSDyENPDEHS		molecular association, regulation	transcription, altered	Nck2(INDUCES); PLCG2(INDUCES); PLCG1(INDUCES); Btk(INDUCES); VAV1(INDUCES)		827; 7669	3	1	0	Sites mutated alone and in combination (Y189,Y178and Y96) prevented binding of PLCG1 and mobization of Ca2+. For NF-AT transcriptional activity Y103,Y194 and Y205 residues were necessary.Tyrosine phosphoryation of BLNK induces MAPK activation. 



	
Gab2	Adaptor/scaffold	Q9UQC2	9846	GAB2	11q14.1	human	S623	PHOSPHORYLATION	454021	ALDFQPSsPSPHRKP		molecular association, regulation		SHP-2(DISRUPTS)		4163	1	3	12	Phosphorylation of this site decreases Gab2 interaction with SHP-2, but leads to increased SHP-2 phosphorylation and activation;  also increased phosphorylation of ERK, but decreased activation of STAT5.  	
CSRP1	Cytoskeletal protein; Motility/polarity/chemotaxis	P21291	1465	CSRP1	1q32	human	Y57	PHOSPHORYLATION	2091906	AVHGEEIyCKSCYGK	PHF5; LIM; zf-C3HC4_2	intracellular localization				2249	1	1	8		
profilin 1	Actin binding protein; Cytoskeletal protein; Motility/polarity/chemotaxis	P02584	513895	PFN1		cow	Y129	PHOSPHORYLATION	450514	GMINKKCyEMASHLR	Profilin	molecular association, regulation	cell motility, induced	ACTB(INDUCES)		26341756	1	17	639	promotes actin filament polymerization in vitro	
TLX1	DNA binding protein	P31314	3195	TLX1	10q24	human	T247	PHOSPHORYLATION	15660705	MTDAQVKtWFQNRRT	Homeobox	molecular association, regulation	cell cycle regulation; transcription, altered		DNA(NOT_REPORTED)	15562528	1	0	0		
NFkB-p65	DNA binding protein; Nuclear receptor co-regulator; Transcription factor	Q04207	19697	Rela		mouse	S467	PHOSPHORYLATION	451145	GVFTDLAsVDNSEFQ		protein degradation; ubiquitination	transcription, inhibited	COMMD1(INDUCES); CUL2(INDUCES)		22632300	13	0	0	TNF induced degradation	
MSK2	EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor)	O75676	8986	RPS6KA4	11q11-q13	human	T687	PHOSPHORYLATION	455803	RSSPPLRtPDVLESS		enzymatic activity, induced				6181	1	13	3		
ELMO1	Cytoskeletal protein; Motility/polarity/chemotaxis	Q92556	9844	ELMO1	7p14.1	human	Y511	PHOSPHORYLATION	455873	SKLQNLSyTEILKIR			cytoskeletal reorganization			6335	1	1	1	mutation of this site impairs cell migration and phagocytosis	
NIFK	RNA binding protein	Q9BYG3	84365	MKI67IP	2q14.3	human	T234	PHOSPHORYLATION	449332	TVDSQGPtPVCTPTF	hNIFK_binding	molecular association, regulation		KI-67(INDUCES)		7199; 2194	1	12	68		
RAD18	DNA repair; EC 6.3.2.-; EC 6.3.2.19; Ligase; UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase	Q9NS91	56852	RAD18	3p25-p24	human	S434	PHOSPHORYLATION	17595902	IQEVLSSsESDSCNS		molecular association, regulation		POLQ(INDUCES)		17482925	1	0	0	promotes POLQ recruitment to stalled replication forks	
MAX	DNA binding protein; Transcription factor	P61244	4149	MAX	14q23	human	S11	PHOSPHORYLATION	449308	NDDIEVEsDEEQPRF	ATG16; Filament; Myosin_tail_1; IncA; Ax_dynein_light; Fib_alpha	activity, inhibited	transcription, altered			9408	4	9	0	phosphorylation-deficient mutant inhibits transcription more efficiently	
ZAP70	EC 2.7.10.2; KINASE; Kinase, protein; Protein kinase, TK; Protein kinase, tyrosine (non-receptor)	P43404	22637	Zap70		mouse	Y492	PHOSPHORYLATION	447505	LGADDSYyTARSAGK	Pkinase_Tyr	intracellular localization; enzymatic activity, induced				5299	15	11	440	weak enzymatic activation	
PKCZ	EC 2.7.11.13; KINASE; Kinase, protein; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor)	Q05513	5590	PRKCZ	1p36.33-p36.2	human	T560	PHOSPHORYLATION	447572	TSEPVQLtPDDEDAI	Pkinase_C		cytoskeletal reorganization	TNNI1(INDUCES); desmin(INDUCES); TPM1(INDUCES); MYO1C(INDUCES); TNNT1(INDUCES)		1243600	10	4	0		
MOR-1	GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR	P33535	25601	Oprm1		rat	S363	PHOSPHORYLATION	447783	STIEQQNsTRVRQNT		molecular association, regulation; receptor desensitization, altered; receptor internalization, altered		ARR3(INDUCES); ARRB2(INDUCES)		1182; 27132404; 2807232	9	6	0		
MIG-6	Inhibitor protein	P05432	313729	Errfi1		rat	S250	PHOSPHORYLATION	3215403	RRLRRSHsGPAGSFN		protein stabilization; molecular association, regulation		14-3-3 theta(INDUCES)		30281300	2	20	34		
IRF3	DNA binding protein; Transcription factor	Q14653	3661	IRF3	19q13.3-q13.4	human	S385	PHOSPHORYLATION	448696	MARVGGAsSLENTVD		activity, induced; molecular association, regulation; intracellular localization; protein conformation	transcription, altered	CBP(DISRUPTS); p300(INDUCES); IRF3(INDUCES)		4260506; 3416; 8584; 2195490; 12263; 1892	6	1	0		
Cdc25C	EC 3.1.3.48; Motility/polarity/chemotaxis; PHOSPHATASE; Protein phosphatase, dual-specificity	P30307	995	CDC25C	5q31	human	T236	PHOSPHORYLATION	451436	VEKFKDNtIPDKVKK	M-inducer_phosp	molecular association, regulation; intracellular localization		KPNB3(DISRUPTS)		3641	1	0	0		
GSTP1	EC 2.5.1.18; Other Amino Acids Metabolism - glutathione; Transferase; Xenobiotic Metabolism - drug metabolism - cytochrome P450; Xenobiotic Metabolism - metabolism by cytochrome P450	P09211	2950	GSTP1	11q13	human	S185	PHOSPHORYLATION	455118	SAYVGRLsARPKLKA	GST_C	activity, induced				4355	1	0	0		
GAP43	Cell surface	P06837	14432	Gap43		mouse	S41	PHOSPHORYLATION	448719	AATKIQAsFRGHITR	IQ		cell growth, altered			7963	14	8	5		
MEK1	EC 2.7.12.2; KINASE; Kinase, protein; Protein kinase, STE; Protein kinase, dual-specificity	Q02750	5604	MAP2K1	15q22.1-q22.33	human	T388	PHOSPHORYLATION	466978	LNQPSTPtHAAGV__		intracellular localization				6841100	1	1	12	nuclear translocation	
G3BP-1	Adaptor/scaffold; EC 3.6.1.-; EC 3.6.4.12; EC 3.6.4.13; Helicase	Q13283	10146	G3BP1	5q33.1	human	S149	PHOSPHORYLATION	449041	VTEPQEEsEEEVEEP		molecular association, regulation; intracellular localization; protein conformation		G3BP-1(DISRUPTS)		2073; 2074	3	46	41		
AQP5	Channel, misc.; Membrane protein, integral; Membrane protein, multi-pass	P55064	362	AQP5	12q13	human	S156	PHOSPHORYLATION	1233703	STDSRRTsPVGSPAL	MIP	phosphorylation	cell cycle regulation			4049514	3	0	0	 increases posphorylation of Rb at S780; affects cell proliferation	
CEACAM1	Cell adhesion; Immunoglobulin superfamily; Membrane protein, integral; Motility/polarity/chemotaxis	P31809	26365	Ceacam1		mouse	S503	PHOSPHORYLATION	448536	QQPNRPTsAPSSPRA		molecular association, regulation	cell growth, altered	Shc1(INDUCES)		1610	8	0	0		
MCM2	DNA binding protein; EC 3.6.4.12	P49736	4171	MCM2	3q21	human	S139	PHOSPHORYLATION	454180	RRGLLYDsDEEDEER	MCM2_N	activity, induced; molecular association, regulation	cell cycle regulation; chromatin organization, altered		DNA(NOT_REPORTED); DNA(INDUCES)	2205200; 9204	4	51	300	MMCM2 phosphorylated forms are differentially bound to chromatin. ; regulates ATPase activity in vitro	
MAF1	Transcription regulation	Q9H063	84232	MAF1	8q24.3	human	S75	PHOSPHORYLATION	477954	SPSRLSKsQGGEEEG	Maf1	activity, inhibited	transcription, induced; transcription, altered			12778829; 14780530; 14780536	3	13	23		
PLK1	EC 2.7.11.21; KINASE; Kinase, protein; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor)	P53350	5347	PLK1	16p12.2	human	S330	PHOSPHORYLATION	4271242	PRFSIAPsSLDPSNR		molecular association, regulation	cell cycle regulation	14-3-3 zeta(INDUCES)		22999500; 27157300	2	0	0		
IRS1	Adaptor/scaffold; Motility/polarity/chemotaxis	P35570	25467	Irs1		rat	S1100	PHOSPHORYLATION	453434	GCRRRHSsETFSAPT		activity, inhibited				1163205	7	19	98	Phosphorylation causes inhibition of insulin signaling.	
CLOCK	ACETYLTRANSFERASE; Acetyltransferase; DNA binding protein; EC 2.3.1.48; Transcription factor	O15516	9575	CLOCK	4q12	human	S431	PHOSPHORYLATION	11087834	FDHSPTPsASSRSSR		protein degradation; phosphorylation	transcription, altered			12021324	1	1	1		
Neu3	EC 3.2.1.18; Glycan Metabolism - other glycan degradation; Hydrolase; Lipid Metabolism - sphingolipid	Q9UQ49	10825	NEU3	11q13.5	human	Y346	PHOSPHORYLATION	450320	QRVDLGIyLNQTPLE	BNR_2	molecular association, regulation; phosphorylation		Grb2(INDUCES)		2945	1	0	0	lowers IRS-1 phosphorylation	
PKCA	EC 2.7.11.13; KINASE; Kinase, protein; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor)	P17252	5578	PRKCA	17q22-q23.2	human	S657	PHOSPHORYLATION	448597	QSDFEGFsYVNPQFV	Pkinase_C	intracellular localization				1173027	22	2	2	Requires dual phosphorylation to locate to pericentrion.	
PDGFRB	EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Protein kinase, TK; Protein kinase, tyrosine (receptor)	P09619	5159	PDGFRB	5q33.1	human	Y751	PHOSPHORYLATION	447508	SKDESVDyVPMLDMK	Pkinase_Tyr	activity, induced; molecular association, regulation; protein conformation; enzymatic activity, induced	cell cycle regulation	Shc1(INDUCES); PIK3C2A(INDUCES); PIK3R1(INDUCES); PIK3CA(INDUCES)		2280; 1173023; 1230; 7991117; 7324110; 7324108; 3825; 1843	19	1	6		
GLUT2	Membrane protein, integral; Membrane protein, multi-pass; Transporter	P12336	25351	Slc2a2		rat	S501	PHOSPHORYLATION	451345	AAEFRKKsGSAPPRK		activity, inhibited				3556	1	0	0	Phosphorylation reduces the initial rate of 3-O-methyl glucose uptake.	
WASP	Adaptor/scaffold; Motility/polarity/chemotaxis	P42768	7454	WAS	Xp11.4-p11.21	human	Y291	PHOSPHORYLATION	447985	AETSKLIyDFIEDQG	PBD	activity, induced; molecular association, regulation	cell motility, altered; cytoskeletal reorganization	WIP(NOT_REPORTED)		1172809; 1768; 11424223; 1309	10	21	681		
prolactin	Cytokine; Motility/polarity/chemotaxis; Secreted; Secreted, signal peptide	P01236	5617	PRL	6p22.2-p21.3	human	S179	PHOSPHORYLATION	17790903	NEIYPVWsGLPSLQM	Hormone_1		cell cycle regulation			17714500	9	0	0	 upregulates p21;  ; upregulates VDR and promotes its nuclear translocation	
PTPRA	EC 3.1.3.48; Membrane protein, integral; Motility/polarity/chemotaxis; PHOSPHATASE; Receptor protein phosphatase, tyrosine	P18052	19262	Ptpra		mouse	Y825	PHOSPHORYLATION	447613	YIDAFSDyANFK___		molecular association, regulation; enzymatic activity, induced		Src(INDUCES); Grb2(INDUCES)		1173025; 10144230; 8788	13	48	2297		
B-Myb	DNA binding protein; Motility/polarity/chemotaxis; Transcription factor	P48972	17865	Mybl2		mouse	T490	PHOSPHORYLATION	452027	SQKVVVTtPLHRDKT	Cmyb_C	activity, induced				3936	2	1	27		
TNNI3	Actin binding protein; Motility/polarity/chemotaxis; Motor protein	P23693	29248	Tnni3		rat	S45	PHOSPHORYLATION	450691	KKSKISAsRKLQLKT			cell motility, altered			2703100	18	1	0	heart contractility and relaxation	
14-3-3 epsilon	Adaptor/scaffold	P62258	7531	YWHAE	17p13.3	human	K50	ACETYLATION	11315836	NLLSVAYkNVIGARR	14-3-3	molecular association, regulation		SF2(DISRUPTS); TSC22D1(DISRUPTS); SFRS6(DISRUPTS); PLEKHQ1(DISRUPTS); Gab2(DISRUPTS); RAF1(DISRUPTS); Dok3(DISRUPTS); SFRS4(DISRUPTS); VASP(DISRUPTS); HDAC4(DISRUPTS); TSC2(DISRUPTS); SFRS10(DISRUPTS); LARP(DISRUPTS); ARAF(DISRUPTS); GBF1(DISRUPTS); SRm300(DISRUPTS)		8156721	0	1	1		
CEACAM1 iso8	Cell adhesion; Immunoglobulin superfamily; Membrane protein, integral; Motility/polarity/chemotaxis	P13688-8	634	CEACAM1	19q13.2	human	T457	PHOSPHORYLATION	3439801	CFLHFGKtGSSGPLQ		phosphorylation	cell differentiation, altered			3433202	4	0	0	FAK Y397 phosphorylation	
ERF	DNA binding protein; Transcription factor	P50548	2077	ERF	19q13	human	S246	PHOSPHORYLATION	456967	RGGPEPLsPFPVSPL		intracellular localization	cell cycle regulation			6956; 6957	2	1	0		
rabphilin 3A	Vesicle protein	P47709	171039	Rph3a		rat	S274	PHOSPHORYLATION	455801	QGLRRANsVQASRPA		intracellular localization				6424	2	5	0		
HMGA2	DNA binding protein	P52927	15364	Hmga2		mouse	S44	PHOSPHORYLATION	4033091	QEPTCEPsPKRPRGR		molecular association, regulation; protein conformation			DNA(DISRUPTS)	10292901	1	15	2		
polycystin 1	Cell adhesion; Membrane protein, integral; Membrane protein, multi-pass	P98161	5310	PKD1	16p13.3	human	S4166	PHOSPHORYLATION	2859800	EPLPSRSsRGSKVSP			cell differentiation, altered			2858607	1	0	0		
BMF	Apoptosis; Cytoskeletal protein	Q96LC9	90427	BMF	15q14	human	S77	PHOSPHORYLATION	22999100	TQTLSPAsPSQGVML			apoptosis, inhibited			22958917	1	0	0		
RPLP2	Ribosomal protein; Translation	P02401	140662	Rplp2		rat	S102	PHOSPHORYLATION	454319	KDEKKEEsEESDDDM	Ribosomal_60s	activity, induced	translation, altered			8697	3	75	308		
EZH2	EC 2.1.1.43; METHYLTRANSFERASE; Methyltransferase; Methyltransferase, protein lysine; Oncoprotein	Q15910	2146	EZH2	7q35-q36	human	T345	PHOSPHORYLATION	4957354	LTAERIKtPPKRPGG		protein degradation; ubiquitination	carcinogenesis, altered; cell growth, induced; cell motility, altered; transcription, altered; cell growth, altered			15754904; 20726610	4	4	2		
TMEM173	Apoptosis; Endoplasmic reticulum; Membrane protein, integral; Membrane protein, multi-pass; Mitochondrial	Q86WV6	340061	TMEM173	5q31.2	human	S358	PHOSPHORYLATION	13201900	VPSTSTMsQEPELLI		activity, induced; molecular association, regulation				12482421	2	1	0	activates IRF-E and enhances interaction between TBK1 and IRF3.	
Shc3 iso2	Adaptor/scaffold; Motility/polarity/chemotaxis	Q92529-2	53358	SHC3	9q22.1	human	Y283	PHOSPHORYLATION	451257	RQGSSDIySTPEGKL		molecular association, regulation		Crk(INDUCES); RapGEF1(INDUCES)		3475	1	1	27		
LRP1	Cell surface; Membrane protein, integral; Motility/polarity/chemotaxis; Receptor, misc.	Q07954	4035	LRP1	12q13.3	human	Y4507	PHOSPHORYLATION	451245	TNFTNPVyATLYMGG		molecular association, regulation; protein conformation		Shc1(INDUCES); SHP-2(INDUCES)		2704313; 3466	5	2	0		
Met	EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Protein kinase, TK; Protein kinase, tyrosine (receptor)	P08581	4233	MET	7q31	human	Y1235	PHOSPHORYLATION	448471	DMYDKEYySVHNKTG	Pkinase_Tyr	activity, induced; protein conformation; phosphorylation; enzymatic activity, induced	cell motility, altered; cell growth, altered	PTP1B(INDUCES); PTPN2(INDUCES)		2838; 1169; 21261103; 6115921; 2852648; 712; 5544	35	11	407		
AT1	GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR	P30556	185	AGTR1	3q24	human	S335	PHOSPHORYLATION	467238	SNLSTKMsTLSYRPS		activity, induced; molecular association, regulation; intracellular localization; receptor internalization, altered		ARRB1(INDUCES); ARRB2(INDUCES)		8345; 8199	2	0	0		
SEPT5 iso2	Cell cycle regulation; Cytoskeletal protein; Hydrolase; Vesicle protein	Q99719-2	5413	SEPT5	22q11.21	human	S17	PHOSPHORYLATION	475075	RLVEQLLsPRTQAQR		molecular association, regulation		STX1A(DISRUPTS)		9261	2	2	2		
caldesmon	Actin binding protein	Q28708	100009077	CALD1		rabbit	S529	PHOSPHORYLATION	448466	QSVDKVTsPTKV___		molecular association, regulation; protein conformation		HSP27(INDUCES); TPM1(DISRUPTS)		8113	15	9	0		
CERK	EC 2.7.1.138; Kinase, lipid; Lipid Metabolism - sphingolipid	Q8TCT0	64781	CERK	22q13.31	human	S427	PHOSPHORYLATION	11485304	LILIRKCsRFNFLRF		enzymatic activity, induced				11419331	1	0	0		
TORC2	Transcription, coactivator/corepressor	Q8BH09	74343	Crtc2		mouse	S275	PHOSPHORYLATION	3174300	PAMNTGGsLPDLTNL	TORC_M	molecular association, regulation; intracellular localization	transcription, altered	14-3-3 beta(INDUCES)		3173900	2	0	0		
MAP4	Cytoskeletal protein; Motility/polarity/chemotaxis	ACK86564	100302596	MAP4		cat	S924	PHOSPHORYLATION	1210622	NVRSKVGsTENIKHQ	Tubulin-binding		cytoskeletal reorganization			13960204	3	28	41		
FAM84A	Unknown function	Q96KN4	151354	FAM84A	2p24.3	human	S38	PHOSPHORYLATION	469624	VGVAYFFsDDEEDLD			cell motility, altered; cytoskeletal reorganization			8265	2	0	0		
GLP1R	GPCR, family 2; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR	P32301	25051	Glp1r		rat	S441	PHOSPHORYLATION	451368	KPLKCPTsSVSSGAT		receptor desensitization, altered				3574	1	0	0		
CREB	DNA binding protein; Transcription factor	Q01147	12912	Creb1		mouse	S133	PHOSPHORYLATION	448228	EILSRRPsYRKILND	pKID	activity, induced; molecular association, regulation; protein conformation; phosphorylation	transcription, induced; signaling pathway regulation; transcription, altered; cell growth, altered	MyoD(INDUCES); p300(INDUCES); CREM(INDUCES); CREB(DISRUPTS); CBP(INDUCES)	DNA(DISRUPTS)	1043; 6842216; 5415; 2661902; 5580; 7324123; 3342608; 4862607; 4317100; 2686; 18378501	214	1	61	CAMK/CREB signaling pathway regulates transcription, activity of sympathetic neurons, and bone mass accrual.; in the presence of 5-HT (seretonin); in vitro and in vivo	
TRPV5	Channel, cation; Membrane protein, integral; Membrane protein, multi-pass; Motility/polarity/chemotaxis	Q9XSM3		Trpv5		rabbit	S299	PHOSPHORYLATION	470108	FLELVVSsKKREARQ		activity, induced; intracellular localization				6337831; 2195472	3	0	0	CaR-dependent channel activation; inhibits caveolar endocytosis of TRPV5	
CD19	Cell surface; Membrane protein, integral	P15391	930	CD19	16p11.2	human	Y409	PHOSPHORYLATION	447935	EEEEGEGyEEPDSEE		activity, induced; molecular association, regulation; phosphorylation		PLCG2(INDUCES); VAV1(INDUCES)		8326	2	0	0	ERK2 phosphorylation; Ca(2+) influx	
PR	DNA binding protein; Nuclear receptor	P06401	5241	PGR	11q22-q23	human	S294	PHOSPHORYLATION	447987	APMAPGRsPLATTVM	Prog_receptor	sumoylation; protein degradation; intracellular localization	transcription, induced; cell adhesion, altered; cell growth, altered			1249; 2630611; 9980413; 5121517	18	0	0	inhibits sumoylation of PR K388	
EGFR	EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Protein kinase, TK; Protein kinase, tyrosine (receptor)	P00533	1956	EGFR	7p12	human	Y1172	PHOSPHORYLATION	448059	ISLDNPDyQQDFFPK		protein degradation; molecular association, regulation; receptor internalization, altered; phosphorylation; enzymatic activity, induced	cell growth, altered	RASA1(INDUCES); VAV2(INDUCES); Dok2(INDUCES); EGFR(INDUCES); Dok1(INDUCES); SHP-1(INDUCES)		2641; 2651; 2311; 2310; 5489; 2852610; 4260; 7309801; 3100; 1064; 2309	33	32	946		
GluR1	Channel, calcium; Channel, ligand-gated; Membrane protein, integral; Membrane protein, multi-pass	P23818	14799	Gria1		mouse	S857	PHOSPHORYLATION	3362102	INEAIRTsTLPRNSG		activity, induced				3361001	1	0	0	synaptic plasticity	
FANCE	DNA repair	Q9HB96	2178	FANCE	6p22-p21	human	S374	PHOSPHORYLATION	476782	LFLGRILsLTSSASR	FA_FANCE	protein degradation; molecular association, regulation; intracellular localization		FANCD2(INDUCES)		9371	1	0	2	required for mitomycin C resistance	
NFAT5	Transcription factor	O94916	10725	NFAT5	16q22.1	human	T135	PHOSPHORYLATION	469161	TVQQHPStPKRHTVL		intracellular localization	transcription, induced			18021001	1	1	10		
Smad2	DNA binding protein; Transcription factor	Q15796	4087	SMAD2	18q21.1	human	T220	PHOSPHORYLATION	448793	QSNYIPEtPPPGYIS		activity, induced; protein stabilization; molecular association, regulation; intracellular localization	transcription, induced	Smad4(INDUCES)		3386; 1956	6	0	0		
desmoplakin 3	Cytoskeletal protein; Motility/polarity/chemotaxis	P14923	3728	JUP	17q21	human	Y550	PHOSPHORYLATION	456972	AAGTQQPyTDGVRME		molecular association, regulation	transcription, induced	desmoplakin(DISRUPTS); CTNNA1(INDUCES)		5375	1	3	138		
IREM-1	Immunoglobulin superfamily; Membrane protein, integral; Receptor, misc.	Q8TDQ1	146722	CD300LF	17q25.1	human	Y284	PHOSPHORYLATION	474547	GPEEPTEySTISRP_		activity, induced; molecular association, regulation		SHP-1(INDUCES)		9304	1	0	0	mutation of site to Phe decreased the inhibitory activity of IREM-1	
NPHP1	Cell adhesion	O15259	4867	NPHP1	2q13	human	Y721	PHOSPHORYLATION	18449509	FDLSEQTyDFLGEMR		molecular association, regulation; intracellular localization		PACS-1(INDUCES)		18410856	1	0	0		
VCP	Chaperone; DNA repair; Endoplasmic reticulum; Hydrolase	P55072	7415	VCP	9p13.3	human	S784	PHOSPHORYLATION	456210	NQGGAGPsQGSGGGT		intracellular localization				7136	1	4	26	localizes to DNA double-strand breaks	
HuR	RNA binding protein	Q15717	1994	ELAVL1	19p13.2	human	S88	PHOSPHORYLATION	474552	LNGLRLQsKTIKVSY	RRM_1		RNA stability, altered		RNA(INDUCES)	9316	2	0	0	Phosphorylation by Chk2 regulates binding of ELAV1 to mRNAs affecting mRNA stabliity.	
CK2-B	KINASE; Protein kinase, regulatory subunit	Q5SRQ6	1460	CSNK2B	6p21.3	human	S21	PHOSPHORYLATION	447646	TSADVKMsSSEEVSW		protein stabilization; enzymatic activity, induced		CK2-B(INDUCES)		1322; 5825	3	11	0		
TNNT2	Motility/polarity/chemotaxis; Motor protein	P50752	21956	Tnnt2		mouse	T297	PHOSPHORYLATION	451557	TRGKAKVtGRWK___	Troponin	phosphorylation	cytoskeletal reorganization			7134	3	0	0	ROCK II induced desensitization to Ca++ and depression in maximal tension.	
Kv1.2	Channel, potassium; Membrane protein, integral; Membrane protein, multi-pass	P16389	3737	KCNA2	1p13	human	Y417	PHOSPHORYLATION	455553	VSNFNYFyHRETEGE		molecular association, regulation		cortactin(DISRUPTS)		5437	1	0	0		
HS1	Adaptor/scaffold; Motility/polarity/chemotaxis	P14317	3059	HCLS1	3q13	human	Y397	PHOSPHORYLATION	451636	EDEPEGDyEEVLEPE		molecular association, regulation; intracellular localization	apoptosis, altered; cell adhesion, altered; cytoskeletal reorganization; transcription, altered	VAV1(INDUCES)		7894; 4010; 4313616	8	1	8		
HDAC4	DEACETYLASE; Deacetylase; EC 3.5.1.98; Hydrolase; Nuclear receptor co-regulator	P56524	9759	HDAC4	2q37.3	human	S298	PHOSPHORYLATION	1322400	ACSSAPGsGPSSPNN		protein degradation; ubiquitination; intracellular localization	cell motility, altered			1172867; 17675064	2	0	0		
Deptor	Apoptosis	Q8TB45	64798	DEPTOR	8q24.12	human	S299	PHOSPHORYLATION	4723878	SSPTLSSsPPVLCNP		protein degradation; molecular association, regulation		BTRC(INDUCES)		21699400; 21699401	2	4	1		
tau	Cytoskeletal protein	P10637	17762	Mapt		mouse	S648	PHOSPHORYLATION	449104	RVQSKIGsLDNITHV	Tubulin-binding	protein degradation				25785413	19	12	0	LKB1-MARK signaling causes proteasome-mediated degradation of Tau. 	
DBNL	Actin binding protein; Motility/polarity/chemotaxis	Q9UJU6	28988	DBNL	7p13	human	S269	PHOSPHORYLATION	467729	KQKERAMsTTSISSP	UPF0560	molecular association, regulation		14-3-3 beta(INDUCES)		21683737	1	30	443	mutation of this site prevents 14-3-3 binding (pan-14-3-3 antibody)	
DOR-1	GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR	P32300	18386	Oprd1		mouse	T353	PHOSPHORYLATION	3146600	RRPRQATtRERVTAC		protein degradation; intracellular localization; receptor internalization, altered				18119118; 8420	2	0	0		
NPY1R	GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR	P21555	29358	Npy1r		rat	S367	PHOSPHORYLATION	2815301	KTSLKQAsPVAFKKI		receptor internalization, altered				4358	1	1	0	may be an artifact of the truncation mutants	
P38A	EC 2.7.1.37; EC 2.7.11.24; KINASE; Kinase, protein; Protein kinase, CMGC; Protein kinase, Ser/Thr (non-receptor)	Q16539	1432	MAPK14	6p21.3-p21.2	human	Y182	PHOSPHORYLATION	447971	TDDEMTGyVATRWYR	Pkinase	activity, induced; phosphorylation; enzymatic activity, induced	cell cycle regulation; apoptosis, altered; cell motility, altered; cytoskeletal reorganization; cell adhesion, altered	P38A(INDUCES)		1268100; 2624105; 7036; 1173013; 5121519; 1172869; 715; 5720; 2624803; 4313623; 7613744	310	68	3676		
S6	Translation	P62754	20104	Rps6		mouse	S236	PHOSPHORYLATION	448093	AKRRRLSsLRASTSK			carcinogenesis, induced			27519661	125	34	1097	Increased Kras induced pancreatic lesions, metaplastic foci, p53 expression	
4E-BP1	Translation; Translation initiation	Q62622	116636	Eif4ebp1		rat	T69	PHOSPHORYLATION	447528	RNSPVAKtPPKDLPT	eIF_4EBP	molecular association, regulation; phosphorylation	translation, altered	eIF4E(DISRUPTS); eIF4E(INDUCES)		15658714; 6650; 842	38	23	9		
IKKA	EC 2.7.11.10; KINASE; Kinase, protein; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor)	O15111	1147	CHUK	10q24-q25	human	S180	PHOSPHORYLATION	447779	DQGSLCTsFVGTLQY	Pkinase	activity, induced; enzymatic activity, induced	chromatin organization, altered; cell motility, altered; transcription, induced			6804602; 12261; 7644600	32	0	0		
P2X3	Channel, ligand-gated; Membrane protein, integral; Membrane protein, multi-pass	P56373	5024	P2RX3	11q12	human	S178	PHOSPHORYLATION	458896	FTIFIKNsIRFPLFN	P2X_receptor	receptor desensitization, altered				7456	1	0	0		
LPP	Adaptor/scaffold; Cytoskeletal protein; Motility/polarity/chemotaxis	Q8BFW7	210126	Lpp		mouse	Y302	PHOSPHORYLATION	448949	GRYYEPYyAAGPSYG			cell cycle regulation; cell motility, altered			2790302	1	19	539		
Irx2	DNA binding protein; Transcription factor	Q9PU52	373975	IRX2		chicken	S326	PHOSPHORYLATION	452193	AALGGRAsPGPPTPA			transcription, altered			4104	1	0	0		
CNR1	GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR	P47746	12801	Cnr1		mouse	S465	PHOSPHORYLATION	22342302	AKVTMSVsTDTSAEA		receptor desensitization, induced				21686207	1	0	1		
KCNK3	Channel, potassium; Membrane protein, integral; Membrane protein, multi-pass	O14649	3777	KCNK3	2p23	human	S393	PHOSPHORYLATION	2840504	GLMKRRSsV______		activity, induced; intracellular localization				18410857	3	0	0		
TLR5	Membrane protein, integral; Receptor, misc.	O60602	7100	TLR5	1q41-q42	human	Y798	PHOSPHORYLATION	473546	VVGSLSQyQLMKHQS	TIR	activity, induced				9192	1	1	0	mutation prevents inflamatory responses in flagellin-treated cells	
MCM3	DNA replication; EC 3.6.4.12	P25206	17215	Mcm3		mouse	S112	PHOSPHORYLATION	2840507	SFGSKHVsPRTLTSC		molecular association, regulation	cell cycle regulation	MCM2(INDUCES); MCM7(INDUCES); MCM5(INDUCES)	DNA(INDUCES)	2831764	2	0	0		
MSK2	EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor)	O75676	8986	RPS6KA4	11q11-q13	human	S324	PHOSPHORYLATION	11489900	PFRPQIRsELDVGNF	Pkinase_C	phosphorylation; enzymatic activity, induced				11419362	1	0	0	stimulates phosphorylation of S196	
AMPKB1	Autophagy; Protein kinase, regulatory subunit	P80386	83803	Prkab1		rat	S108	PHOSPHORYLATION	448522	SKLPLTRsQNNFVAI	CBM_48	enzymatic activity, inhibited				1677	8	35	2		
FOXO3A	Autophagy; DNA binding protein; Transcription factor	Q9WVH4	56484	Foxo3		mouse	S317	PHOSPHORYLATION	453423	SRTNSNAsTVSGRLS		intracellular localization				12482251	6	0	1	nuclear export in FOXO6/FOXO3A chimera	
IRF3	DNA binding protein; Transcription factor	Q14653	3661	IRF3	19q13.3-q13.4	human	S405	PHOSPHORYLATION	449032	SHPLSLTsDQYKAYL		activity, induced; molecular association, regulation; intracellular localization; protein conformation; phosphorylation	transcription, altered	CBP(INDUCES)		2062; 6337817; 2195490; 12263	4	0	0		
PKN1	EC 2.7.11.13; KINASE; Kinase, protein; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor)	Q16512	5585	PKN1	19p13.12	human	T774	PHOSPHORYLATION	447835	GYGDRTStFCGTPEF	Pkinase	molecular association, regulation; enzymatic activity, induced	cytoskeletal reorganization	PDK1(INDUCES)		765; 766	7	5	303		
LXR-alpha	DNA binding protein; Motility/polarity/chemotaxis; Nuclear receptor	Q13133	10062	NR1H3	11p11.2	human	S198	PHOSPHORYLATION	469114	SLPPRASsPPQILPQ		protein conformation	transcription, altered			7532701	3	0	0	inhibits CCL24 expression 	
separase	EC 3.4.22.49; Protease	P60330	105988	Espl1		mouse	T1341	PHOSPHORYLATION	447675	EEEGPPCtPKPPGRA		molecular association, regulation	cytoskeletal reorganization			28722139	3	2	0	S1120 T1341 AA mutant -fewer cold-stable kinetochore-microtubule attachments and lacks tension	
GTF2I iso2	DNA binding protein; Transcription, coactivator/corepressor	P78347-2	2969	GTF2I	7q11.23	human	S371	PHOSPHORYLATION	457074	GIPFRRPsTYGIPRL	GTF2I	molecular association, regulation	transcription, altered	Smad3(INDUCES)		7006	2	3	131		
MRLC2	Contractile protein	P18666	50685	Myl12b		rat	S20	PHOSPHORYLATION	448595	KRPQRATsNVFAMFD	EF_hand_5	intracellular localization; protein conformation	exocytosis, altered			4214821; 720	50	28	282		
PKCE	EC 2.7.11.13; KINASE; Kinase, protein; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor)	Q02156	5581	PRKCE	2p21	human	T566	PHOSPHORYLATION	448787	LNGVTTTtFCGTPDY	Pkinase	molecular association, regulation; intracellular localization; enzymatic activity, induced		AKAP9(DISRUPTS)		1173; 5121504	6	1	0	AKAP9 anchors hypophosphorylated PKCE at Golgi/centrosome for phosphorylaton.	
MCM4	DNA replication; EC 3.6.4.12	P33991	4173	MCM4	8q11.2	human	S54	PHOSPHORYLATION	448667	ELQPMPTsPGVDLQS		activity, inhibited				2551	4	4	5		
FGF2	Activator protein; Motility/polarity/chemotaxis	P09038	2247	FGF2	4q26	human	S250	PHOSPHORYLATION	3146601	NNYNTYRsRKYTSWY	FGF	molecular association, regulation	cell differentiation, altered; cell growth, altered	CK2-B(INDUCES)		8506	1	0	0		
MEKK3	EC 2.7.11.25; KINASE; Kinase, protein; Protein kinase, STE; Protein kinase, Ser/Thr (non-receptor)	Q99759	4215	MAP3K3	17q23.3	human	S520	PHOSPHORYLATION	12607406	RLQTICMsGTGMRSV	Pkinase	enzymatic activity, induced				12525215	2	0	0	essential for MEKK3-mediated IKK-beta/NFkB activation	
TSC1	Motility/polarity/chemotaxis; Tumor suppressor	Q92574	7248	TSC1	9q34	human	T310	PHOSPHORYLATION	478102	SYGCATStPYSTSRL	Hamartin	molecular association, regulation		PLK1(INDUCES)		2865403	1	0	1		
ASBT	Membrane protein, integral; Membrane protein, multi-pass; Transporter	Q62633	29500	Slc10a2		rat	S335	PHOSPHORYLATION	453445	NDMDPMPsFQETNKG		protein degradation				4152	1	2	0		
CDK1	EC 2.7.11.22; EC 2.7.11.23; KINASE; Kinase, protein; Motility/polarity/chemotaxis; Protein kinase, CMGC; Protein kinase, Ser/Thr (non-receptor)	P11440	12534	Cdk1		mouse	T14	PHOSPHORYLATION	447608	IEKIGEGtYGVVYKG	Pkinase	enzymatic activity, inhibited	cell cycle regulation			7991105	19	60	1661		
SGK1	EC 2.7.11.1; KINASE; Kinase, protein; Motility/polarity/chemotaxis; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor)	Q06226	29517	Sgk1		rat	S421	PHOSPHORYLATION	448429	AEAFLGFsYAPPMDS	Pkinase_C	enzymatic activity, induced	transcription, induced			1968312; 1268	19	0	0	involved in spatial memory formation by increasing expression of zif268 in hippocampus, through phosphorylation of SRF S99 and CREB S133	
TH	Amino Acid Metabolism - tyrosine; EC 1.14.16.2; Endoplasmic reticulum; Mitochondrial; Oxidoreductase; Vesicle protein	P24529	21823	Th		mouse	S31	PHOSPHORYLATION	448544	KQAEAVTsPRFIGRR	Chorion_2; TOH_N	protein stabilization; enzymatic activity, induced				4246	32	5	0		
dynactin 1	Microtubule binding protein; Motility/polarity/chemotaxis; Motor protein	Q14203	1639	DCTN1	2p13	human	S179	PHOSPHORYLATION	15512801	SASAGELsSSEPSTP		molecular association, regulation; intracellular localization	cell cycle regulation			15235215	2	0	0	inhibits dynactin 1 interaction with microtubules	
CAMK2A	EC 2.7.11.17; KINASE; Kinase, protein; Protein kinase, CAMK; Protein kinase, Ser/Thr (non-receptor)	P11275	25400	Camk2a		rat	T286	PHOSPHORYLATION	447797	SCMHRQEtVDCLKKF		molecular association, regulation; intracellular localization; protein conformation; enzymatic activity, induced; phosphorylation	cytoskeletal reorganization	DRD3(INDUCES); RPT6(INDUCES); NMDAR2A(INDUCES); CAMK2A(INDUCES); NMDAR2B(INDUCES); SYN1(INDUCES); CAMK2B(INDUCES); calmodulin(INDUCES); CAMK2A(DISRUPTS); MARCKS(INDUCES)		6829203; 2669500; 4554; 14148606; 15331009; 4650409; 6763; 3999; 22882605; 3991; 9103; 4650411; 4650410; 3342604	100	21	55	T286 phosphorylation is required for targeting CaMK2-alpha to inhibitory synapses. ; regulates spine size	
CYLD	EC 3.1.2.15; EC 3.4.19.12; Protease; Ubiquitin conjugating system; Ubiquitin-specific protease	Q9NQC7	1540	CYLD	16q12.1	human	S432	PHOSPHORYLATION	12173909	KMPNTNGsIGHSPLS		ubiquitination				12156302	1	0	0	induces ubiquitination of TRAF2	
Cx43	Channel, misc.; Membrane protein, integral; Membrane protein, multi-pass; Motility/polarity/chemotaxis	P17302	2697	GJA1	6q22.31	human	Y265	PHOSPHORYLATION	447815	KDCGSQKyAYFNGCS		molecular association, regulation; protein processing		Src(INDUCES); ZO1(INDUCES)		2757	11	1	10	Src regulates processing of Cx43 at cell surface. ; Cx43 Y265 mutants bound ZO1 in the presence of constitutively active Src.  ; Src SH2 prevents binding of Cx43 to ZO1.	
SHP-2	EC 3.1.3.48; Motility/polarity/chemotaxis; PHOSPHATASE; Protein phosphatase, tyrosine (non-receptor)	P35235	19247	Ptpn11		mouse	Y279	PHOSPHORYLATION	474206	ENKNKNRyKNILPFD	Y_phosphatase	phosphorylation; enzymatic activity, induced	cell cycle regulation			4651314	1	4	11		
CIITA	DNA binding protein; Transcription, coactivator/corepressor	P33076	4261	CIITA	16p13	human	S1050	PHOSPHORYLATION	448442	AASLLRLsLYNNCIC			transcription, altered			1462	1	0	0		
K17	Cytoskeletal protein	Q9QWL7	16667	Krt17		mouse	T9	PHOSPHORYLATION	464290	TTTIRQFtSSSSIKG		molecular association, regulation	cell cycle regulation	14-3-3 sigma(NOT_REPORTED)		7892	1	0	0	Mutation of T8 and S43 (to alanine) causes reduced phosphorylation of Akt S473 and p70S6K T389.	
Per2	Transcription factor	O54943	18627	Per2		mouse	S53	PHOSPHORYLATION	9439800	TGRDSQGsDCDDNGK		protein degradation	transcription, altered			9201010	1	0	0	 ; S53A mutant of Per2 impairs circadian gene expression	
PAX6	DNA binding protein; Motility/polarity/chemotaxis; Transcription factor	P63015	18508	Pax6		mouse	T373	PHOSPHORYLATION	458810	GRSYDTYtPPHMQTH			transcription, induced			7464	1	0	1		
MEF2D	DNA binding protein; Transcription factor	O89038	81518	Mef2d		rat	S430	PHOSPHORYLATION	449407	SIKSEPVsPSRERSP			apoptosis, induced			2212	3	4	16		
REM1	G protein; G protein, monomeric, RGK	O35929	19700	Rem1		mouse	S288	PHOSPHORYLATION	1211203	RRALKARsKSCHNLA		molecular association, regulation; intracellular localization		14-3-3 beta(DISRUPTS)		1172800	1	0	0		
4E-T	Karyopherin; Nuclear import; Translation	Q9NRA8	56478	EIF4ENIF1	22q11.2	human	S513	PHOSPHORYLATION	3213594	NLESHLMsPAEIPGQ	EIF4E-T	molecular association, regulation		4E-T(INDUCES)		26341738	1	3	2	required for processing bodies (PBs or P bodies) assembly	
MARK2	EC 2.7.11.1; EC 2.7.11.26; KINASE; Kinase, protein; Protein kinase, CAMK; Protein kinase, Ser/Thr (non-receptor)	Q7KZI7	2011	MARK2	11q13.1	human	T596	PHOSPHORYLATION	453427	RGVSSRStFHAGQLR		molecular association, regulation; enzymatic activity, inhibited; intracellular localization		14-3-3 beta(INDUCES)		4143; 5354432; 4142	4	3	1		
MKP-3	EC 3.1.3.16; EC 3.1.3.48; Motility/polarity/chemotaxis; Protein phosphatase, dual-specificity	Q16828	1848	DUSP6	12q22-q23	human	S174	PHOSPHORYLATION	5938001	LGGLRISsDSSSDIE		protein degradation				5930044	1	0	0		
NPM1	RNA binding protein; Translation	P06748	4869	NPM1	5q35.1	human	K212	ACETYLATION	466414	QKSNQNGkDSKPSST	Nop14; TFIIF_alpha	molecular association, regulation; intracellular localization	transcription, altered	H3(INDUCES)		8156707	1	3	31	K212/215/229/230/257/267/292R  mutant	
ANPB	EC 4.6.1.2; Guanylyl cyclase; KINASE; Kinase, protein; Lyase; Membrane protein, integral; Nucleotide Metabolism - purine; Protein kinase, RGC; Protein kinase, dual-specificity; Receptor, misc.	P16067	116564	Npr2		rat	S523	PHOSPHORYLATION	447761	TLSLRGSsYGSLMTA	Pkinase_Tyr	activity, induced				2568	3	3	0		
HNF4 alpha	DNA binding protein; Nuclear receptor; Transcription factor	P41235	3172	HNF4A	20q13.12	human	Y288	PHOSPHORYLATION	22996303	IDDNEYAyLKAIIFF	Hormone_recep	protein degradation; intracellular localization; phosphorylation	transcription, inhibited			22958931	1	1	0	reduced nuclear localization and protein stability; multistep phosphorylation by Src, phosphorylating Y23 first, which interacts with the Src SH2 domain, followed by phosphorylation of Y286, Y288  	
CaR	GPCR, family 3; Membrane protein, integral; Membrane protein, multi-pass; Motility/polarity/chemotaxis; Receptor, GPCR	P41180	846	CASR	3q13	human	S899	PHOSPHORYLATION	15507601	SNVSRKRsSSLGGST		molecular association, regulation; intracellular localization		14-3-3 beta(INDUCES)		15235219	1	0	1		
TAP	Motility/polarity/chemotaxis; Vesicle protein	P41542	56042	Uso1		rat	S940	PHOSPHORYLATION	450465	PVEEEDEsGDQEDDD	Uso1_p115_C	intracellular localization				3016	3	36	41	phosphorylation of site increases association with Golgi membranes in vitro, but not in vivo 	
ATP6V1A	EC 3.6.3.14; Energy Metabolism - oxidative phosphorylation; Hydrolase	P50516	11964	Atp6v1a		mouse	S175	PHOSPHORYLATION	14913505	LPPRNRGsVTYIAPP		intracellular localization; enzymatic activity, induced				14780532	2	1	0		
GluR1	Channel, calcium; Channel, ligand-gated; Membrane protein, integral; Membrane protein, multi-pass	P42261	2890	GRIA1	5q31.1	human	C829	PALMITOYLATION	9486202	LVALIEFcYKSRSES		molecular association, regulation; intracellular localization; phosphorylation		EPB41L1(DISRUPTS)		9158103	1	0	0	depalmitoylation of C829 (aka C811) enhances GluR1 phosphorylation at S834 (aka S816) and S836 (aka S818); depalmitoylation of C829 (aka C811) enhances the interaction with EPB41L1 (4.1N) and receptor insertion into plasma membrane	
JAK2	EC 2.7.10.2; KINASE; Kinase, protein; Protein kinase, TK; Protein kinase, tyrosine (non-receptor)	Q62120	16452	Jak2		mouse	Y972	PHOSPHORYLATION	470145	EYLGTKRyIHRDLAT	Pkinase_Tyr	protein conformation; phosphorylation; enzymatic activity, induced				3309505; 13354701	3	1	0		
CLASP2	Cytoskeletal protein; Motility/polarity/chemotaxis	O75122	23122	CLASP2	3p22.3	human	S507	PHOSPHORYLATION	481392	QGCSREAsPSRLSVA			cytoskeletal reorganization			23940901	1	6	2		
ITGB4 iso2	Cell adhesion; Membrane protein, integral; Motility/polarity/chemotaxis; Receptor, misc.	P16144-2	3691	ITGB4	17q25	human	Y1422	PHOSPHORYLATION	450140	SSTLTRDyNSLTRSE		molecular association, regulation	cell adhesion, altered	Shc1(INDUCES)		2765	1	0	44		
NKEF-A	EC 1.11.1.15; Oxidoreductase	Q06830	5052	PRDX1	1p34.1	human	T183	PHOSPHORYLATION	476233	GWKPGSDtIKPDVQK	1-cysPrx_C	enzymatic activity, inhibited				27619320	1	3	0		
CCNE2	Activator protein; Cell cycle regulation	O96020	9134	CCNE2	8q22.1	human	T392	PHOSPHORYLATION	452067	VCNGGIMtPPKSTEK		protein degradation; ubiquitination				5930031; 3170	2	5	2		
GSTP1	EC 2.5.1.18; Other Amino Acids Metabolism - glutathione; Transferase; Xenobiotic Metabolism - drug metabolism - cytochrome P450; Xenobiotic Metabolism - metabolism by cytochrome P450	P09211	2950	GSTP1	11q13	human	Y4	PHOSPHORYLATION	462289	____MPPyTVVYFPV	GST_N	protein conformation; enzymatic activity, induced				7613720	1	1	4		
MYBPC3	Myosin binding protein	Q14896	4607	MYBPC3	11p11.2	human	S284	PHOSPHORYLATION	471080	AGGGRRIsDSHEDTG			cytoskeletal reorganization			12662610	17	6	24	regulation of cardiac myofilament function	
TRHR	GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR	Q01717	25570	Trhr		rat	S364	PHOSPHORYLATION	1229700	IKESDRFsTELDDIT		receptor internalization, altered				1172827; 14551416	3	0	0		
BKR2	GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR	P30411	624	BDKRB2	14q32.1-q32.2	human	Y332	PHOSPHORYLATION	451672	SCLNPLVyVIVGKRF	7tm_1; TM	molecular association, regulation; receptor internalization, altered; intracellular localization				3776	1	0	0		
GPM6A	Cell surface; Channel, calcium; Membrane protein, integral; Membrane protein, multi-pass	Q812E9	306439	Gpm6a		rat	T10	PHOSPHORYLATION	11488702	ENMEEGQtQKGCFEC		activity, induced				11484425	1	0	0		
Kit	EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Protein kinase, TK; Protein kinase, tyrosine (receptor)	P10721	3815	KIT	4q11-q12	human	Y553	PHOSPHORYLATION	13876401	KYLQKPMyEVQWKVV		enzymatic activity, induced				13852012	1	1	0		
LAT iso2	Adaptor/scaffold; Membrane protein, integral	O43561-2	27040	LAT	16p11.2	human	Y226	PHOSPHORYLATION	448006	EEEGAPDyENLQELN	LAT	molecular association, regulation; phosphorylation	cell differentiation, altered; transcription, altered	GADS(INDUCES); Grb2(INDUCES)		2891; 3632; 1909	9	2	76	leads to ERK phosphorylation, NF-AT transcription	
PKM2	Carbohydrate Metabolism - glycolysis and gluconeogenesis; Carbohydrate Metabolism - pyruvate; EC 2.7.1.40; KINASE; Kinase, other; Kinase, protein; Mitochondrial; Nucleotide Metabolism - purine; Protein kinase, tyrosine (non-receptor)	P52480	18746	Pkm2		mouse	Y105	PHOSPHORYLATION	450528	FASDPILyRPVAVAL	PK	molecular association, regulation; enzymatic activity, inhibited	carcinogenesis, induced; cell growth, altered	PKM2(DISRUPTS)		30280003; 12769400	5	23	398		
TLR4	Membrane protein, integral; Receptor, misc.	O00206	7099	TLR4	9q33.1	human	Y680	PHOSPHORYLATION	478361	IYDAFVIySSQDEDW	TIR	molecular association, regulation; phosphorylation	transcription, altered	IRAK1(DISRUPTS); MYD88(DISRUPTS)		9628	1	0	0	IRAK1 short form	
tau iso8	Cytoskeletal protein	P10636-8	4137	MAPT	17q21.1	human	S199	PHOSPHORYLATION	447927	GDRSGYSsPGSPGTP		O-GlcNAc glycosylation; molecular association, regulation; intracellular localization; protein conformation	cytoskeletal reorganization	WWOX(INDUCES); Fyn(DISRUPTS); tau(INDUCES)		5955609; 5955610; 9223; 17630402; 8165400; 6115906; 7021	57	17	33	hyperphosphorylation of this site decreases O-GlcNAcylation of tau ; Phosphotylated sites found in the somato-dendritic campartment but not in the axon, where tau was not phosphorylated (T205 and T217),  or not simultaneously phosphorylated (T231 and 235). ; Pseudophosphorylation mutants S199E, T212E, S214E, double mutant T212E/S214E, and triple mutant S199E/202E/T205E showed increased filament mass at equilibrium in vitro, as compared to WT tau. S212E mutant showed longer filament lengths compared to WT in vitro.	
APP iso4	Apoptosis; Cell surface; Membrane protein, integral; Receptor, misc.; Transcription factor	P05067-4	351	APP	21q21.3	human	T668	PHOSPHORYLATION	448523	VEVDAAVtPEERHLS	APP_amyloid	protein stabilization; molecular association, regulation; protein processing; intracellular localization; phosphorylation	apoptosis, altered; exocytosis, altered; transcription, induced; cytoskeletal reorganization; transcription, altered; cell growth, altered	Fe65(DISRUPTS); TFCP2(INDUCES); APBA2(INDUCES); Fe65(INDUCES); 14-3-3 gamma(DISRUPTS); Pin1(INDUCES)		2378500; 7391; 2816; 2610804; 7245; 12006; 7762; 6754; 6271027; 2297; 3733	30	2	3	necessary for intraneuronal AB accumulation which leads to cell death (neurotoxicity); regulates Tau and GSK3B phosphorylation	
AurA	EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor)	O14965	6790	AURKA	20q13	human	S284	PHOSPHORYLATION	2370900	WSVHAPSsRRTTLCG	Pkinase	enzymatic activity, induced				2365408	2	0	0		
CUTL1	DNA binding protein; Membrane protein, integral; Transcription factor	P53564	13047	Cux1		mouse	S1155	PHOSPHORYLATION	457411	ILGLTQGsVSDLLAR	CUT	molecular association, regulation	transcription, altered		DNA(DISRUPTS)	7046	1	0	0	 	
GRF-1	GTPase activating protein, Rac/Rho; Motility/polarity/chemotaxis; Transcription factor	Q9NRY4	2909	ARHGAP35	19q13.3	human	T1173	PHOSPHORYLATION	3213723	GRFASYRtSFSVGSD		molecular association, regulation; activity, inhibited		Rnd1(DISRUPTS)		6804206	1	2	0		
BORA	Activator protein	Q6PGQ7	79866	BORA	13q22.1	human	S497	PHOSPHORYLATION	2512942	SSNIQMDsGYNTQNC	PRCH	protein degradation; molecular association, regulation	cell cycle regulation	BTRC(INDUCES)		2451810; 7532700	2	0	0	PLK1 phosphorylation of site promotes BORA interaction with, and degradation by, BTRC (SCF-beta-TrCP ligase)	
CTNND1 iso3	Actin binding protein; Adaptor/scaffold; Cell adhesion; G protein regulator, misc.; Motility/polarity/chemotaxis	P30999-3	12388	Ctnnd1		mouse	Y280	PHOSPHORYLATION	450398	HRFHPEPyGLEDDQR			cell cycle regulation; cell motility, altered			2790302	2	13	164		
ARHGAP3	GTPase activating protein, Rac/Rho	P52757	1124	CHN2	7p15.3	human	Y21	PHOSPHORYLATION	482808	VSSDAEEyQPPIWKS		activity, inhibited	cell motility, altered			11755	1	0	0	negatively controls Rac-GAP activity	
Jun	Transcription factor	P05412	3725	JUN	1p32-p31	human	S243	PHOSPHORYLATION	450451	PGETPPLsPIDMESQ	DUF3450; HAP1_N	molecular association, regulation; ubiquitination; activity, inhibited; phosphorylation	transcription, altered	FBXW7(INDUCES); FBXW7(DISRUPTS); SP1(DISRUPTS)		4702; 2713706; 3879; 22599404; 6610	10	12	10		
N-WASP	Adaptor/scaffold; Motility/polarity/chemotaxis	O08816	682507	Wasl		rat	S480	PHOSPHORYLATION	3149548	KRSKAIHsSDEDEDD			endocytosis, induced; cytoskeletal reorganization			27127703	3	9	2	Phosphorylation induces CK2-A1 and N-WASP complex formation and regulate cell surface EGFR levels by endocytosis.  Phosphorylation reduces actin polymerization.	
CDK5	EC 2.7.1.37; EC 2.7.11.22; KINASE; Kinase, protein; Protein kinase, CMGC; Protein kinase, Ser/Thr (non-receptor)	Q03114	140908	Cdk5		rat	Y15	PHOSPHORYLATION	448022	EKIGEGTyGTVFKAK	Pkinase		cell motility, altered			4042529	14	26	875		
SUFU	Adaptor/scaffold; Transcription, coactivator/corepressor	Q9UMX1	51684	SUFU	10q24.32	human	S342	PHOSPHORYLATION	4786843	LAHDRAPsRKDSLES	SUFU_C	protein stabilization; intracellular localization				18410834	1	5	0		
AT1	GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR	P25095	24180	Agtr1		rat	S331	PHOSPHORYLATION	452091	AKSHSSLsTKMSTLS		activity, induced				8139	2	1	0		
Borealin	Cell cycle regulation	Q53HL2	55143	CDCA8	1p34.3	human	T278	PHOSPHORYLATION	482837	QICSSIRtHK_____	F-box		cell growth, altered			11759	1	0	0		
TIEG2	C2H2-type zinc finger protein; DNA binding protein; Transcription factor	O14901	8462	KLF11	2p25	human	S124	PHOSPHORYLATION	456010	PSTRTPVsPQVTDSK		molecular association, regulation		SIN3A(DISRUPTS)		6578	1	0	13		
PKCZ	EC 2.7.11.13; KINASE; Kinase, protein; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor)	P09217	25522	Prkcz		rat	T560	PHOSPHORYLATION	447572	TSEPVQLtPDDEDVI	Pkinase_C	protein degradation; phosphorylation; enzymatic activity, induced	cytoskeletal reorganization	desmin(DISRUPTS); TNNT1(DISRUPTS); TPM1(INDUCES); MYO1C(INDUCES); TNNI1(DISRUPTS)		1243600; 6582; 4735	10	4	0		
TH iso2	Amino Acid Metabolism - tyrosine; EC 1.14.16.2; Endoplasmic reticulum; Mitochondrial; Oxidoreductase; Vesicle protein	P07101-2	7054	TH	11p15.5	human	S58	PHOSPHORYLATION	448544	SYTPTPRsPRFIGRR	TOH_N	enzymatic activity, induced				7484	32	5	0		
B-Myb	DNA binding protein; Motility/polarity/chemotaxis; Transcription factor	P48972	17865	Mybl2		mouse	T524	PHOSPHORYLATION	450112	DNTPHTPtPFKNALE	Cmyb_C	activity, induced	transcription, induced			9072	2	0	7		
NFM	Cytoskeletal protein	P08553	18040	Nefm		mouse	S610	PHOSPHORYLATION	448044	AKSPMPKsPVEEVKP			cytoskeletal reorganization			7072905	3	19	14	slightly altered axoplasmic organization in 7S/A mice mutant	
Hck	EC 2.7.10.2; KINASE; Kinase, protein; Protein kinase, TK; Protein kinase, tyrosine (non-receptor)	P08103	15162	Hck		mouse	Y520	PHOSPHORYLATION	448322	YTATESQyQQQP___		enzymatic activity, inhibited				1653	3	6	332	Y519 phosphorylation keeps the kinase in an inactive state and does not permit autophosphorylation at Y49 and Y408.	
Akt1	EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor)	P31749	207	AKT1	14q32.32	human	Y474	PHOSPHORYLATION	447859	PHFPQFSySASGTA_	Pkinase_C	enzymatic activity, induced				913	1	1	13		
TPD52	Calcium-binding protein; Endoplasmic reticulum	P55327	7163	TPD52	8q21	human	S176	PHOSPHORYLATION	465974	KNSPTFKsFEEKVEN	TPD52; IncA; V_ATPase_I; ERM; Sec1; Wx5_PLAF3D7; AAA_13; Occludin_ELL	molecular association, regulation; intracellular localization	cell cycle regulation	LAMP1(INDUCES)		15785204; 12021330	4	26	31	modulates cytokinesis	
RIMS1	Adaptor/scaffold; Vesicle protein	Q9JIR4	84556	Rims1		rat	S413	PHOSPHORYLATION	450481	ARHERRHsDVALPHT		activity, induced				3101	3	4	0	Phosphorylation of RIM1alpha S413 is required for presynaptic LTP (long-term potentiation).	
TGFBR1	EC 2.7.11.30; KINASE; Kinase, protein; Membrane protein, integral; Protein kinase, Ser/Thr (receptor); Protein kinase, TKL; Receptor, misc.	P36897	7046	TGFBR1	9q22	human	T176	PHOSPHORYLATION	4331007	PFISEGTtLKDLIYD	TGF_beta_GS		cell growth, altered			4332501	1	0	0		
PKCE	EC 2.7.11.13; KINASE; Kinase, protein; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor)	P16054	18754	Prkce		mouse	S368	PHOSPHORYLATION	2085101	NNIRKALsFDNRGEE	DUF1631	molecular association, regulation		14-3-3 beta(INDUCES)		1968355	3	6	0		
DYN1	EC 3.6.5.5; Hydrolase; Microtubule binding protein; Motility/polarity/chemotaxis; Motor protein; Vesicle protein	P21575	140694	Dnm1		rat	S857	PHOSPHORYLATION	455277	ASPSRPEsPRPPFDL		molecular association, regulation; intracellular localization		amphiphysin(DISRUPTS)		25723405	4	7	0	During LTP S857 dephosphorylation occurs in distal apical dendrites.	
ZFRA		Q6DQH2		Apbb2		mouse	S8	PHOSPHORYLATION	2868604	MSSRRSSsCKYCEQD	PyrI_C	intracellular localization	apoptosis, induced			6271200; 2856305	2	0	0	translocation of Zfra, WWOX, and p53 to mitochondria 	
TSC2	Cell cycle regulation; GTPase activating protein, misc.; Nuclear receptor co-regulator; Tumor suppressor	P49816	24855	Tsc2		rat	S1385	PHOSPHORYLATION	450216	FQPSQPLsKSSSSPE		activity, inhibited; phosphorylation	translation, altered; apoptosis, inhibited			8973	2	0	1	inhibits mTOR signaling.  required for Wnt-3a to stimulation phosphorylation of S6K and 4EBP1 and increase protein levels of cyclin D1 and VEGF (cyclin D1 through translation not transcription).	
NELF	Adaptor/scaffold	Q9EPI6	117536	Nelf		rat	S180	PHOSPHORYLATION	27713502	AKLVPGPsPRAFGLE		intracellular localization	apoptosis, inhibited; transcription, induced			27619358	1	1	0	 induced higher transcript levels of BDNF and Arc/Arg3.1;  cell survival; translocates from synapse to nucleus	
PKCA	EC 2.7.11.13; KINASE; Kinase, protein; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor)	P17252	5578	PRKCA	17q22-q23.2	human	T638	PHOSPHORYLATION	448685	TRGQPVLtPPDQLVI	Pkinase_C	intracellular localization				1173027	17	6	1	Requires dual phosphorylation to locate to pericentrion.	
SRPK2	EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, CMGC; Protein kinase, Ser/Thr (non-receptor)	NP_001100045	296753	Srpk2		rat	T485	PHOSPHORYLATION	483237	PSRDRSRtVSASSTG			apoptosis, altered			9980417	1	3	0		
EphA3	EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Protein kinase, TK; Protein kinase, tyrosine (receptor)	P29320	2042	EPHA3	3p11.2	human	S768	PHOSPHORYLATION	7445291	KVSDFGLsRVLEDDP	Pkinase_Tyr	protein conformation				25779406	1	3	0		
MEKK1	EC 2.7.11.25; EC 6.3.2.-; KINASE; Kinase, protein; Ligase; Protein kinase, STE; Protein kinase, Ser/Thr (non-receptor); UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase	Q13233	4214	MAP3K1	5q11.2	human	S67	PHOSPHORYLATION	3053616	RQLRKVRsVELDQLP		molecular association, regulation		JNK1(DISRUPTS)		8636	1	1	0		
NHE1	Membrane protein, integral; Membrane protein, multi-pass; Motility/polarity/chemotaxis; Transporter	P19634	6548	SLC9A1	1p36.1-p35	human	S703	PHOSPHORYLATION	448347	MSRARIGsDPLAYEP		activity, induced	transcription, altered			1196	6	40	184		
FAF1	Apoptosis; Nuclear receptor co-regulator	Q9UNN5	11124	FAF1	1p33	human	S289	PHOSPHORYLATION	450286	ITDVHMVsDSDGDDF		intracellular localization	cell cycle regulation			5354442; 2917	2	1	0	 mediates the proteasome-dependent degradation of AurA; induces G2/M arrest	
vimentin	Cytoskeletal protein; Motility/polarity/chemotaxis	P20152	22352	Vim		mouse	S73	PHOSPHORYLATION	449025	SAVRLRSsVPGVRLL	Filament_head; DUF2464		cytoskeletal reorganization			2057	11	26	31		
Ig-alpha	Immunoglobulin superfamily; Membrane protein, integral	P11911	12518	Cd79a		mouse	Y182	PHOSPHORYLATION	473649	DYEDENLyEGLNLDD	ITAM	activity, induced; molecular association, regulation; phosphorylation	cell differentiation, altered	Syk(INDUCES)		9303; 1692; 3517	3	1	13	Ca(2+) signaling	
FHOD1	Actin binding protein	Q9Y613	29109	FHOD1	16q22	human	T1141	PHOSPHORYLATION	2035402	NRKSLRRtLKSGLGD		activity, induced	cytoskeletal reorganization; cell growth, altered	FHOD1(DISRUPTS)		17431547; 1968357	2	0	0	autoinhibitory interaction between C- and N-terminal part of FHOD1 is attenuated in S1130D/S1136D/T1140D triple mutant	
PDE4A	EC 3.1.4.17; Nucleotide Metabolism - purine; Phosphodiesterase	P54748	25638	Pde4a		rat	S140	PHOSPHORYLATION	458389	TTSQRREsFLYRSDS		protein conformation; enzymatic activity, induced				18410830	4	7	0		
FAK iso3	EC 2.7.1.112; EC 2.7.10.2; KINASE; Kinase, protein; Protein kinase, TK; Protein kinase, tyrosine (non-receptor)	P34152-3	14083	Ptk2		mouse	Y576	PHOSPHORYLATION	447889	RYMEDSTyYKASKGK	Pkinase_Tyr	activity, induced; molecular association, regulation	cell adhesion, altered	P130Cas(INDUCES)		2864; 2886; 1698	68	40	2552		
PTPRA	EC 3.1.3.48; Membrane protein, integral; Motility/polarity/chemotaxis; PHOSPHATASE; Receptor protein phosphatase, tyrosine	P18433	5786	PTPRA	20p13	human	Y798	PHOSPHORYLATION	447613	YIDAFSDyANFK___		enzymatic activity, induced	cytoskeletal reorganization			3960	13	48	2297	Y798F mutant showed a different morphology compared to wild-type. 	
SKAP55	Adaptor/scaffold; Motility/polarity/chemotaxis	Q86WV1	8631	SKAP1	17q21.32	human	Y271	PHOSPHORYLATION	455436	EKEEEDIyEVLPDEE		molecular association, regulation		Fyn(INDUCES); Grb2(INDUCES)		5338	1	4	125	SKAP55-Y271F mutant abolished the enhancing effect of  wild-type SKAP55 on MAPK activation after TCR cross-linking. 	
TIM-3	Membrane protein, integral; Receptor, misc.	Q8VIM0	171285	Havcr2		mouse	Y256	PHOSPHORYLATION	470136	IRSEENIyTIEENVY		molecular association, regulation		BAT3(DISRUPTS)		26341713	2	0	0		
SPTA1	Cytoskeletal protein; Motility/polarity/chemotaxis	P02549	6708	SPTA1	1q21	human	Y422	PHOSPHORYLATION	13421405	HKHEIDSyDDRFQSA	Spectrin		cytoskeletal reorganization			13359104	1	1	0		
Chk1	EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, CAMK; Protein kinase, Ser/Thr (non-receptor)	Q8AYC9	374260	STT3A		chicken	S286	PHOSPHORYLATION	465527	SSGGVTEsPGALPKH	Paramyxo_PNT	enzymatic activity, induced	cell cycle regulation			20722939	5	5	13		
NFE2L1	DNA binding protein; Transcription factor	Q14494	4779	NFE2L1	17q21.3	human	S599	PHOSPHORYLATION	454236	PSALKKGsKEKQADF		molecular association, regulation		C/EBP-beta(INDUCES)		4235	1	0	0		
GFAP	Cytoskeletal protein	P14136	2670	GFAP	17q21	human	S38	PHOSPHORYLATION	449621	LGPGTRLsLARMPPP	Filament_head	protein stabilization				2254	6	0	0		
MITF iso9	DNA binding protein; Transcription factor	O75030-9	4286	MITF	3p14.2-p14.1	human	S73	PHOSPHORYLATION	450264	PGSSAPNsPMAMLTL		activity, induced; protein degradation; ubiquitination	cell cycle regulation; transcription, induced; transcription, altered			27102300; 2968; 15235201; 7005	16	0	0	enhances cell survival 	
EphB1	EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Protein kinase, TK; Protein kinase, tyrosine (receptor)	P54762	2047	EPHB1	3q21-q23	human	Y778	PHOSPHORYLATION	450471	DDTSDPTyTSSLGGK	Pkinase_Tyr	molecular association, regulation		Src(NOT_REPORTED); Shc1(NOT_REPORTED)		3019	2	4	17		
CD163L1	Membrane protein, integral; Receptor, misc.	P30205	338056	CD163L1		cow	Y1326	PHOSPHORYLATION	470034	DALAEAVyEELDYLL		intracellular localization	endocytosis, altered			6374703; 8959	2	0	0		
CTNNB1	Actin binding protein; Cell adhesion; Motility/polarity/chemotaxis; Nuclear receptor co-regulator; Transcription factor	P35222	1499	CTNNB1	3p21	human	T112	PHOSPHORYLATION	3075001	EGMQIPStQFDAAHP		protein degradation; intracellular localization	cell growth, inhibited; cell motility, altered; transcription, induced; cell motility, inhibited	CTNNA1(INDUCES)		6366210; 8383	2	0	0		
Shc1	Adaptor/scaffold; Apoptosis; Mitochondrial; Motility/polarity/chemotaxis	P29353	6464	SHC1	1q21	human	S54	PHOSPHORYLATION	457345	PPLPGDDsPTTLCSF		protein stabilization	apoptosis, induced			7013	1	0	0	Phosphorylation necessary to promote activated-Rac1-induced oxidative stress (ROS-induced apoptosis).	
RSK2	EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor)	P18654	110651	Rps6ka3		mouse	S369	PHOSPHORYLATION	448064	TAKTPKDsPGIPPSA	Pkinase_C	enzymatic activity, induced				1263; 2852652	9	20	19		
Shc1	Adaptor/scaffold; Apoptosis; Mitochondrial; Motility/polarity/chemotaxis	P98083	20416	Shc1		mouse	Y349	PHOSPHORYLATION	448509	EEPPDHQyYNDFPGK		activity, induced; molecular association, regulation; phosphorylation	cell differentiation, altered	Grb2(INDUCES)		6563; 6347; 3053; 6039	27	15	922		
NFAT1	DNA binding protein; Transcription factor	Q60591	18019	Nfatc2		mouse	S53	PHOSPHORYLATION	455325	PIAHKAIsSPSGLAY			transcription, induced			1188	0	2	2		
K8	Cytoskeletal protein	P11679	16691	Krt8		mouse	S80	PHOSPHORYLATION	448539	TVNQSLLsPLKLEVD	IncA; Glyco_transf_8	molecular association, regulation; intracellular localization	apoptosis, inhibited; cytoskeletal reorganization			8153; 1030; 7768	25	2	9	phosphorylation decreased in naturally-occurring K8 Gly61Cys mutant (more susceptible to liver injury and apoptosis)	
Ret	EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Protein kinase, TK; Protein kinase, tyrosine (receptor)	P07949	5979	RET	10q11.2	human	Y952	PHOSPHORYLATION	447628	VTLGGNPyPGIPPER	Pkinase_Tyr	enzymatic activity, induced	cell growth, altered			8770; 1261	2	0	0		
PKAR1A	Protein kinase, regulatory subunit	P10644	5573	PRKAR1A	17q23-q24	human	S83	PHOSPHORYLATION	450936	DSREDEIsPPPPNPV		molecular association, regulation		RFC2(DISRUPTS)		10296918; 28723105	2	58	235	decreased affinity for cAMP	
CK1D	EC 2.7.11.1; EC 2.7.11.26; KINASE; Kinase, protein; Protein kinase, CK1; Protein kinase, Ser/Thr (non-receptor)	Q06486	64462	Csnk1d		rat	S370	PHOSPHORYLATION	483997	MERERKVsMRLHRGA		intracellular localization; enzymatic activity, inhibited				11984	2	0	0		
TOP2A	EC 5.99.1.3; Isomerase	P11388	7153	TOP2A	17q21-q22	human	T1343	PHOSPHORYLATION	448763	FSDFDEKtDDEDFVP		intracellular localization				6562	4	6	14		
CSFR	EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Protein kinase, TK; Protein kinase, tyrosine (receptor)	P09581	12978	Csf1r		mouse	Y721	PHOSPHORYLATION	448364	SSQGVDTyVEMRPVS	Pkinase_Tyr	molecular association, regulation; enzymatic activity, induced	cell differentiation, altered; cell motility, altered; cytoskeletal reorganization; cell growth, altered	PLCG1(INDUCES); SOCS1(INDUCES); PIK3R1(INDUCES)		2852655; 3824; 4651302; 7324131; 3340207; 2852611	14	0	1		
KOR-1	GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR	P34975	29335	Oprk1		rat	Y157	PHOSPHORYLATION	3082309	TMMSVDRyIAVCHPV	EVC2_like; 7tm_1	activity, induced				8600	1	0	0	potentiation for KIR3 activation	
IRF3	DNA binding protein; Transcription factor	Q14653	3661	IRF3	19q13.3-q13.4	human	S386	PHOSPHORYLATION	448684	ARVGGASsLENTVDL		activity, induced; molecular association, regulation; intracellular localization; protein conformation; phosphorylation	transcription, altered	p300(INDUCES); IRF3(INDUCES); CBP(INDUCES)		4260506; 3416; 15331029; 14551405; 8584; 2195490; 12263; 1892	7	3	0		
desmin	Cytoskeletal protein; Motility/polarity/chemotaxis	P17661	1674	DES	2q35	human	T17	PHOSPHORYLATION	449613	RVSSYRRtFGGAPGF	Filament_head		cytoskeletal reorganization			2253	1	2	0	Mutated desmin sites showed failure of desmin filaments to segregate into daughter cells. 	
4E-T	Karyopherin; Nuclear import; Translation	Q9NRA8	56478	EIF4ENIF1	22q11.2	human	S301	PHOSPHORYLATION	14572931	DAVLPEQsPGDFDFN	EIF4E-T	molecular association, regulation		4E-T(INDUCES)		26341738	1	7	7	required for processing bodies (PBs or P bodies) assembly	
HRI	EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor); Translation	Q9Z2R9	15467	Eif2ak1		mouse	T485	PHOSPHORYLATION	447595	GKGTRTHtSRVGTCL	Pkinase	phosphorylation; enzymatic activity, induced				2258	1	1	0		
SEPT5	Cell cycle regulation; Cytoskeletal protein; Hydrolase; Vesicle protein	Q9JJM9	116728	Sept5		rat	S327	PHOSPHORYLATION	454379	TQDSRMEsPIPILPL		molecular association, regulation	exocytosis, altered	STX1A(DISRUPTS)		2704315	1	10	2		
Kv7.1	Channel, potassium; Membrane protein, integral; Membrane protein, multi-pass	P51787	3784	KCNQ1	11p15.5	human	S468	PHOSPHORYLATION	2999201	YDSSVRKsPTLLEVS	KCNQ_channel	activity, induced				8604	1	1	0		
PACT	Activator protein; RNA binding protein; RNA processing	O75569	8575	PRKRA	2q31.2	human	S287	PHOSPHORYLATION	470038	PITVCHGsGISCGNA	dsrm		apoptosis, altered			8920	3	0	0	activates PKR	
neurogenin 1	Cell development/differentiation; DNA binding protein; Transcription factor	P70595	29410	Neurog1		rat	S179	PHOSPHORYLATION	7590801	PCLPGPPsPASDTES			transcription, induced; cell growth, altered			7543502	1	0	0		
CADPS	Vesicle protein	Q62717	26989	Cadps		rat	S5	PHOSPHORYLATION	7712502	___MLDPsSSEEESD		activity, induced	exocytosis, altered			7601405	1	1	0		
BubR1	EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor)	O60566	701	BUB1B	15q15	human	T620	PHOSPHORYLATION	767908	RAARFVStPFHEIMS		protein stabilization; molecular association, regulation	cell cycle regulation; cytoskeletal reorganization	PLK1(INDUCES)		762713	1	1	0	in vitro and in vivo association with PLK1	
SPRY2	Adaptor/scaffold; Inhibitor protein; Motility/polarity/chemotaxis	O43597	10253	SPRY2	13q31.1	human	Y269	PHOSPHORYLATION	3978701	FLPCLWCyLPAKGCL	Sprouty	activity, inhibited; phosphorylation	transcription, altered			4413	1	0	0		
NIPA	Cell cycle regulation; Ubiquitin conjugating system	Q80YV2	232679	Zc3hc1		mouse	S353	PHOSPHORYLATION	449745	PIVSRTRsWESSSPV		molecular association, regulation	cell cycle regulation	CUL1(DISRUPTS)		26341728	4	19	31	ERK2 phosphorylation at G2/M is sufficient dissociation of SCF core complex at G2/M.	
IRF7	DNA binding protein; Transcription factor	P70434	54123	Irf7		mouse	S438	PHOSPHORYLATION	486438	SLGLCLSsTNSLYED			transcription, induced		DNA(INDUCES)	12173	1	0	0		
ITGB2	Cell adhesion; Cell surface; Membrane protein, integral; Motility/polarity/chemotaxis; Receptor, misc.	P05107	3689	ITGB2	21q22.3	human	T759	PHOSPHORYLATION	448535	PLFKSATtTVMNPKF	Integrin_b_cyt	molecular association, regulation		kindlin-3(INDUCES)		28722117	2	0	0		
NEDD1	Cell cycle regulation	Q8NHV4	121441	NEDD1	12q23.1	human	S637	PHOSPHORYLATION	9379000	HSLLERYsVNEGLVA	FliM	molecular association, regulation	cell cycle regulation			9201031	1	1	0	important for binding of NEDD1 with gamma-tubulin	
NMDAR1	Channel, calcium; Channel, ligand-gated; Membrane protein, integral; Membrane protein, multi-pass	P35439	24408	Grin1		rat	S889	PHOSPHORYLATION	449107	AITSTLAsSFKRRRS		molecular association, regulation		calmodulin(DISRUPTS)		1706	4	0	1		
SLC6A4	Membrane protein, integral; Membrane protein, multi-pass; Transporter	P31645	6532	SLC6A4	17q11.2	human	T613	PHOSPHORYLATION	7576401	ERIIKSItPETPTEI		molecular association, regulation; intracellular localization		vimentin(DISRUPTS)		7543512	1	0	1		
Casp9	Apoptosis; EC 3.4.22.62; Protease	P55211	842	CASP9	1p36.21	human	T125	PHOSPHORYLATION	449563	PEVLRPEtPRPVDIG		activity, inhibited	apoptosis, altered; apoptosis, induced			7360; 1193005	6	1	4	inhibits apoptosis during mitosis	
MKP-3	EC 3.1.3.16; EC 3.1.3.48; Motility/polarity/chemotaxis; Protein phosphatase, dual-specificity	Q16828	1848	DUSP6	12q22-q23	human	S159	PHOSPHORYLATION	455265	DGSCSSSsPPLPVLG		protein degradation				4429	4	0	0		
PRPK	EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor)	Q96S44	112858	TP53RK	20q13.2	human	S250	PHOSPHORYLATION	1981300	RLRGRKRsMVG____		enzymatic activity, induced				1981100	1	0	7		
CDK6	EC 2.7.11.22; KINASE; Kinase, protein; Protein kinase, CMGC; Protein kinase, Ser/Thr (non-receptor)	Q64261	12571	Cdk6		mouse	D224	PHOSPHORYLATION	10359104	PLFRGSSdVDQLGKI	Pkinase; DNA_pol_E_B	intracellular localization				10353914	1	0	0		
TK	EC 2.7.1.21; KINASE; Kinase, other; Nucleotide Metabolism - pyrimidine; Xenobiotic Metabolism - drug metabolism - other enzymes	P04183	7083	TK1	17q23.2-q25.3	human	S13	PHOSPHORYLATION	448816	LPTVLPGsPSKTRGQ		protein degradation; molecular association, regulation; enzymatic activity, inhibited		TK(DISRUPTS)		3060; 1991	3	4	1	decreases tetramerization (increases dimer proportion)	
CXCR4	GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR	P61073	7852	CXCR4	2q21	human	S324	PHOSPHORYLATION	6140803	LTSVSRGsSLKILSK		activity, induced; protein degradation; molecular association, regulation; ubiquitination; intracellular localization		ITCH(INDUCES)		6066708	4	5	4	binding in vitro and in vivo	
VEGFR2	EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Protein kinase, TK; Protein kinase, tyrosine (receptor)	P35918	16542	Kdr		mouse	Y949	PHOSPHORYLATION	447903	RFRQGKDyVGELSVD	Pkinase_Tyr	molecular association, regulation	cell motility, altered; cytoskeletal reorganization	TSAd(INDUCES)		6918	12	1	3		
HDAC4	DEACETYLASE; Deacetylase; EC 3.5.1.98; Hydrolase; Nuclear receptor co-regulator	P56524	9759	HDAC4	2q37.3	human	S302	PHOSPHORYLATION	17797200	APGSGPSsPNNSSGS		protein degradation; ubiquitination; intracellular localization	cell motility, altered			17675064	1	0	0		
PDCD4	Apoptosis	Q53EL6	27250	PDCD4	10q24	human	S67	PHOSPHORYLATION	458381	KRRLRKNsSRDSGRG		protein degradation; molecular association, regulation	cell cycle regulation; translation, altered; cell growth, altered	BTRC(INDUCES)		2587201	2	1	40		
NEUROD1	DNA binding protein; Transcription factor	Q64289	29458	Neurod1		rat	S274	PHOSPHORYLATION	465680	PSFDGPLsPPLSING	Neuro_bHLH	intracellular localization				8117	2	0	0		
H2AX	DNA binding protein; Helicase	P16104	3014	H2AFX	11q23.3	human	T137	PHOSPHORYLATION	455687	PSGGKKAtQASQEY_		molecular association, regulation; intracellular localization		H1B(DISRUPTS)		1903003; 14148619	5	7	11		
p53	Activator protein; DNA binding protein; Motility/polarity/chemotaxis; Nuclear receptor co-regulator; Transcription factor; Tumor suppressor	P04637	7157	TP53	17p13.1	human	K101	UBIQUITINATION	486292	SSSVPSQkTYQGSYG	DEC-1_N; P53	protein degradation; intracellular localization				12136	1	2	0		
TRHR	GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR	Q01717	25570	Trhr		rat	S383	PHOSPHORYLATION	465594	YVSTTKVsFDDTCLA		receptor internalization, altered				8037	1	0	0	S383, T365, T371 are important for the receptor internalization	
C/EBP-alpha	DNA binding protein; Transcription factor	P05554	24252	Cebpa		rat	S21	PHOSPHORYLATION	448308	PMSSHLQsPPHAPSN		molecular association, regulation	cell cycle regulation; cell growth, inhibited; cell differentiation, induced; transcription, inhibited	E2F3(INDUCES); E2F2(INDUCES)		25255530	7	0	0	E2F-dependent transactivation	
SAV1	Adaptor/scaffold	Q9H4B6	60485	SAV1	14q13-q23	human	S36	PHOSPHORYLATION	21507300	LLRNLMPsFIRHGPT	SynMuv_product	protein conformation	apoptosis, induced			21386602	1	1	1	 self-dimerization; increase in protein level	
ITGA4	Cell adhesion; Membrane protein, integral; Motility/polarity/chemotaxis; Receptor, misc.	P13612	3676	ITGA4	2q31.3	human	Y1024	PHOSPHORYLATION	7705802	NRRDSWSyINSKSND		molecular association, regulation		PXN iso2(INDUCES)		7543539	3	0	3		
WNK1	EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor)	Q9H4A3	65125	WNK1	12p13.3	human	S382	PHOSPHORYLATION	454105	KRASFAKsVIGTPEF	Pkinase	enzymatic activity, induced				2195492; 2653903	6	4	0		
PKR	EC 2.7.10.2; EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor); Translation	P19525	5610	EIF2AK2	2p22-p21	human	S83	PHOSPHORYLATION	3181640	NKEKKAVsPLLLTTT		enzymatic activity, induced				9075	1	4	3		
restin	Cytoskeletal protein	Q9JK25	65201	Rsn		rat	S319	PHOSPHORYLATION	2509335	ASSLSSMsSVASSVS		molecular association, regulation; protein conformation		TUBA1C(DISRUPTS)		15031338	1	2	0		
ANXA2	Calcium-binding protein; Lipid binding protein; Motility/polarity/chemotaxis	P07355	302	ANXA2	15q22.2	human	S26	PHOSPHORYLATION	450879	TPPSAYGsVKAYTNF		molecular association, regulation; intracellular localization	cell cycle regulation	S100A10(DISRUPTS)		3039; 2725511; 17431540; 3177	5	12	107	promotes DNA synthesis and cell proliferation	
CSF2RB	Membrane protein, integral; Receptor, cytokine	P32927	1439	CSF2RB	22q13.1	human	Y882	PHOSPHORYLATION	2358800	KALKQQDyLSLPPWE		activity, induced	transcription, altered; cell growth, altered			2722	2	0	0		
CACNB1	Channel, calcium	P54283	50688	Cacnb1		rat	S348	PHOSPHORYLATION	459046	IVYIKITsPKVLQRL	Guanylate_kin	activity, induced				7447	1	0	0		
IREB2	RNA binding protein; Translation	P48200	3658	IREB2	15q25.1	human	S157	PHOSPHORYLATION	2850010	LQKAGKLsPVKVQPK		molecular association, regulation	translation, altered		RNA(DISRUPTS)	2831750	1	10	0	regulates the iron-independent synthesis of ferritin 	
RSC1A1	Vesicle protein	Q29106		RSC1A1		pig	S370	PHOSPHORYLATION	10433802	LHELLVIsSKPALEN		intracellular localization				10362101	1	1	0	increases nuclear export 	
5-HT(1B)	GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR	P28334	15551	Htr1b		mouse	S154	PHOSPHORYLATION	10897604	ITDAVEYsAKRTPKR	7tm_1; ABC2_membrane_2	activity, induced; receptor internalization, altered				10353926	1	0	0		
eNOS	Amino Acid Metabolism - arginine and proline; EC 1.14.13.39; Oxidoreductase	Q7YSG7	397557	NOS3		pig	S1179	PHOSPHORYLATION	447884	TSRIRTQsFSLQERH		phosphorylation; enzymatic activity, induced				3342615; 4465	141	8	7	S1179D mutation show greater vascular reactivity, have less infarct volume, and have improved cerebral blood flow as compared with S1179A. 	
NG2	Cell adhesion; Membrane protein, integral	Q00657	81651	Cspg4		rat	T2314	PHOSPHORYLATION	483998	ELLQFCRtPNPALRN		intracellular localization	cell growth, altered			11962	1	0	1		
MKK7	EC 2.7.12.2; KINASE; Kinase, protein; Protein kinase, STE; Protein kinase, dual-specificity	O14733	5609	MAP2K7	19p13.3-p13.2	human	T275	PHOSPHORYLATION	447698	LVDSKAKtRSAGCAA	Pkinase	enzymatic activity, induced	transcription, altered			3278	2	0	1		
DSN1	Cell cycle regulation	Q9H410	79980	DSN1	20q11.23	human	S109	PHOSPHORYLATION	3595501	KETNRRKsLHPIHQG	Mis12_component	intracellular localization				3301210	2	5	4	 stabilizes microtubule-kinetochore attachment; regulates association of proteins (CENP-E, Nuf2) with the kinetochore	
SLC28A2	Membrane protein, integral; Membrane protein, multi-pass; Transporter	Q62773	60423	Slc28a2		rat	S46	PHOSPHORYLATION	4700175	EEVTQGHsLKDGLGH		intracellular localization				22723935	1	2	0		
SLC6A2	Membrane protein, integral; Membrane protein, multi-pass; Transporter	P23975	6530	SLC6A2	16q12.2	human	T258	PHOSPHORYLATION	465613	SLWKGVKtSGKVVWI	SNF	intracellular localization; activity, inhibited				8095	2	0	0	effect observed in T258, S259 double mutant	
p21Cip1	Cell cycle regulation; Inhibitor protein	P38936	1026	CDKN1A	6p21.2	human	S114	PHOSPHORYLATION	478191	EEDHVDLsLSCTLVP		protein degradation				9365	1	0	0	ubiquitination-independent degradation	
PRMT5	Cell cycle regulation; EC 2.1.1.-; EC 2.1.1.125; METHYLTRANSFERASE; Methyltransferase; Methyltransferase, protein arginine; RNA processing	O14744	10419	PRMT5	14q11.2	human	Y307	PHOSPHORYLATION	18545700	FAKGYEDyLQSPLQP	PRMT5	molecular association, regulation; enzymatic activity, inhibited	carcinogenesis, altered; cell growth, altered	PRMT5(DISRUPTS)		18410835	1	0	0	contributes to the mutant Jak2 V617F -induced myeloproliferative phenotype; negatively regulates hematopoietic stem/progenitor cell expansion and erythroid differentiation	
HER4	EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Protein kinase, TK; Protein kinase, tyrosine (receptor)	Q15303	2066	ERBB4	2q33.3-q34	human	Y875	PHOSPHORYLATION	2045333	LEGDEKEyNADGGKM	Pkinase_Tyr	molecular association, regulation		PLCG2(INDUCES)		4651319	0	1	8		
LAB	Adaptor/scaffold; Membrane protein, integral	Q9GZY6	7462	LAT2	7q11.23	human	Y233	PHOSPHORYLATION	450646	EEDGEPDyVNGEVAA		molecular association, regulation	cell differentiation, altered	PLCG1(INDUCES); Grb2(INDUCES)		3080; 1172831	3	1	6		
SHPS1	Cell adhesion; Cell surface; Membrane protein, integral; Motility/polarity/chemotaxis; Receptor, misc.	P97710	25528	Sirpa		rat	Y501	PHOSPHORYLATION	451115	PEPSFSEyASVQVQR		molecular association, regulation		SHP-2(INDUCES)		3309	5	10	142		
ENSA	Inhibitor protein	O43768	2029	ENSA	1q21.3	human	S109	PHOSPHORYLATION	477819	DLPQRKSsLVTSKLA	Endosulfine	molecular association, regulation; protein conformation		SNCA(DISRUPTS)		5014016	1	17	48		
DRAK2	EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, CAMK; Protein kinase, Ser/Thr (non-receptor)	Q8BG48	98267	Stk17b		mouse	S12	PHOSPHORYLATION	1851300	RFDCRSVsGLLTTTP		activity, induced				2626204	1	2	0	Ca(2+) mobilization	
CUTL1	DNA binding protein; Membrane protein, integral; Transcription factor	P53564	13047	Cux1		mouse	S583	PHOSPHORYLATION	457409	VLGLSQGsVSEILAR	CUT	molecular association, regulation	transcription, altered		DNA(DISRUPTS)	7046	1	0	1	 	
RAF1	EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, Ser/Thr (non-receptor); Protein kinase, TKL	P04049	5894	RAF1	3p25	human	S29	PHOSPHORYLATION	455310	FDGSSCIsPTIVQQF		molecular association, regulation; intracellular localization; enzymatic activity, inhibited		HRas(DISRUPTS)		4487	2	4	2		
CTNNB1	Actin binding protein; Cell adhesion; Motility/polarity/chemotaxis; Nuclear receptor co-regulator; Transcription factor	P35222	1499	CTNNB1	3p21	human	S675	PHOSPHORYLATION	457120	QDYKKRLsVELTSSL		activity, induced; molecular association, regulation; protein stabilization; intracellular localization	transcription, induced	p300(INDUCES)		25255522; 14654301; 1919602; 6970	9	29	13		
FPR1	GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Motility/polarity/chemotaxis; Receptor, GPCR	P21462	2357	FPR1	19q13.4	human	T339	PHOSPHORYLATION	450846	SDTATNStLPSAEVE		receptor desensitization, altered; receptor internalization, altered				3130	1	0	0		
mTOR	Autophagy; EC 2.7.11.1; KINASE; Kinase, protein; Motility/polarity/chemotaxis; Protein kinase, ATYPICAL; Protein kinase, Ser/Thr (non-receptor)	Q9JLN9	56717	Mtor		mouse	S2481	PHOSPHORYLATION	447498	TVPESIHsFIGDGLV		enzymatic activity, induced				14146316	37	13	1		
PDK1	EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor)	O55173	81745	Pdpk1		rat	Y9	PHOSPHORYLATION	447696	ARTTSQLyDAVPIQS		enzymatic activity, induced	translation, altered; cell adhesion, altered			4313624	5	1	6	Induces fibronectin expression and deposition and increases AngII mesangial cell hypertrophy	
p14ARF		Q8N726	1029	CDKN2A	9p21	human	T8	PHOSPHORYLATION	27523604	MVRRFLVtLRIRRAC		protein stabilization; intracellular localization	cell growth, induced			27519637	1	0	0	T8-p induces accumulation of the protein both in the cytoplasm and in the nucleus. Cytoplasmic localized ARF is phosphorylated.	
IkB-alpha	DNA binding protein; Inhibitor protein	Q63746	25493	Nfkbia		rat	Y42	PHOSPHORYLATION	448737	DSMKDEDyEQMVKEL		activity, induced	cell growth, altered			6801	14	1	25		
AurB	EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor)	Q96GD4	9212	AURKB	17p13.1	human	S331	PHOSPHORYLATION	22259700	HPWVRANsRRVLPPS		molecular association, regulation; intracellular localization; enzymatic activity, induced	cell cycle regulation	survivin(INDUCES)		21683759	1	0	0	;  required for optimal association of survivin with the CPC;  required for optimal chromosome alignment and segregation; localizes to kinetochores in unperturbed prometaphase	
TOPORS	Cell cycle regulation; EC 6.3.2.-; EC 6.3.2.19; Ligase; UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase	Q9NS56	10210	TOPORS	9p21	human	S98	PHOSPHORYLATION	453973	QTVPADAsPDSKCPI		protein degradation; molecular association, regulation; ubiquitination; enzymatic activity, induced		UBE2D1(INDUCES)		5930013	1	24	1	regulates the ubiquitin, but not the SUMO ligase activity of TOPORS	
ETV1	DNA binding protein; Transcription factor	P41164	14009	Etv1		mouse	S191	PHOSPHORYLATION	3059602	HRFRRQLsEPCNSFP	ETS_PEA3_N	activity, inhibited	transcription, altered			8496	3	1	3	in Mv1Lu cells (mutation shows no effect in HeLa cells)	
NUP98 iso2	Motility/polarity/chemotaxis; Nucleoporin	P52948-2	4928	NUP98	11p15.5	human	S636	PHOSPHORYLATION	4740143	QQDGDEDsLVSHFYT		intracellular localization				18331300	1	10	2	as multiple sites (13PM) mutant 	
RFA2	DNA replication	P15927	6118	RPA2	1p35	human	S29	PHOSPHORYLATION	448338	QSPGGFGsPAPSQAE		intracellular localization	cell cycle regulation			22913902; 9980422	8	2	0		
PDGFRB	EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Protein kinase, TK; Protein kinase, tyrosine (receptor)	P05622	18596	Pdgfrb		mouse	Y1020	PHOSPHORYLATION	447523	PNESDNDyIIPLPDP		phosphorylation				1690	19	0	0	tyrosine phosphorylation of Gab1	
MCM2	DNA binding protein; EC 3.6.4.12	P49736	4171	MCM2	3q21	human	S41	PHOSPHORYLATION	452312	RTDALTSsPGRDLPP		activity, induced; molecular association, regulation	cell cycle regulation; chromatin organization, altered		DNA(NOT_REPORTED); DNA(INDUCES)	2205200; 9204	4	32	22	MMCM2 phosphorylated forms are differentially bound to chromatin. ; regulates ATPase activity in vitro	
POU4F1	Cell development/differentiation; DNA binding protein; Transcription factor	Q01851	5457	POU4F1	13q31.1	human	T39	PHOSPHORYLATION	6311909	IRRACLPtPPLQSNL		activity, induced	cell differentiation, altered; transcription, induced			6277004	1	0	0	activation of galanin promoter induced by retinoic acid 	
MDC1	Cell cycle regulation	Q14676	9656	MDC1	6p21.3	human	T220	PHOSPHORYLATION	4213801	AFNLNSDtDVEEGQQ		molecular association, regulation	cell cycle regulation	NBS1(INDUCES)		4042508	1	1	5	MDC1-NBS1 interaction regulates intra-S-phase checkpoint activation	
Fos	DNA binding protein; Motility/polarity/chemotaxis; Transcription factor	P01100	2353	FOS	14q24.3	human	T232	PHOSPHORYLATION	448491	GGLPEVAtPESEEAF		activity, induced; intracellular localization	transcription, altered			2460; 8961	5	0	0		
PDHA1	Amino Acid Metabolism - valine, leucine and isoleucine biosynthesis; Carbohydrate Metabolism - butanoate; Carbohydrate Metabolism - citrate (TCA) cycle; Carbohydrate Metabolism - glycolysis and gluconeogenesis; Carbohydrate Metabolism - pyruvate; EC 1.2.4.1; Mitochondrial; Oxidoreductase	P08559	5160	PDHA1	Xp22.1	human	S300	PHOSPHORYLATION	448259	SMSDPGVsYRTREEI	E1_dh	enzymatic activity, inhibited				1673; 2509	20	45	471		
SSTR2	GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR	P30874	6752	SSTR2	17q24	human	S341	PHOSPHORYLATION	7652103	GTDDGERsDSKQDKS		receptor internalization, altered				18410845; 18415116	7	0	0		
Casp9	Apoptosis; EC 3.4.22.62; Protease	P55211	842	CASP9	1p36.21	human	Y153	PHOSPHORYLATION	455198	RGNADLAyILSMEPC		activity, induced; molecular association, regulation	apoptosis, induced	p53(INDUCES)		4415	1	0	0		
p53	Activator protein; DNA binding protein; Motility/polarity/chemotaxis; Nuclear receptor co-regulator; Transcription factor; Tumor suppressor	P04637	7157	TP53	17p13.1	human	S9	PHOSPHORYLATION	447538	EEPQSDPsVEPPLSQ	P53_TAD	acetylation; phosphorylation	cell cycle regulation; apoptosis, altered; apoptosis, induced; transcription, altered			6115915; 5010605; 7253; 5004513; 5967	33	1	1		
Rap1GAP	GTPase activating protein, Ras; Motility/polarity/chemotaxis	P47736	5909	RAP1GAP	1p36.1-p35	human	S499	PHOSPHORYLATION	3190708	PFGSRRSsAIGIENI		activity, induced				6804215	1	11	24	increased Rap1 activity	
Rb	Nuclear receptor co-regulator; Transcription, coactivator/corepressor; Tumor suppressor	P33568	24708	Rb1		rat	S780	PHOSPHORYLATION	450022	PIPHIPRsPYKFSSS	Rb_C	molecular association, regulation		HDAC1(INDUCES)		7119507	8	9	65		
TIF1B	EC 6.3.2.-; KINASE; Kinase, protein; Ligase; Nuclear receptor co-regulator; Protein kinase, ATYPICAL; Protein kinase, atypical; Transcription, coactivator/corepressor; UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase	Q13263	10155	TRIM28	19q13.4	human	Y517	PHOSPHORYLATION	464439	PGSTTEDyNLIVIER		molecular association, regulation; phosphorylation	DNA repair, induced	HP1 alpha(INDUCES)	DNA(NOT_REPORTED)	27959900	1	3	133	stimulates phosphorylation of TIF1B S473 and TIF1B S824 in DNA damage response; involved in DNA damage response; inhibits association of HP1alpha with chromatin	
ATF-1	Transcription factor	P18846	466	ATF1	12q13	human	S36	PHOSPHORYLATION	465558	AQQVSSLsESEESQD		molecular association, regulation; phosphorylation		CBP(DISRUPTS)		15658718	3	0	0	primes for S47/S50/S51 phosphorylation	
Cx43	Channel, misc.; Membrane protein, integral; Membrane protein, multi-pass; Motility/polarity/chemotaxis	P08050	24392	Gja1		rat	S257	PHOSPHORYLATION	465456	TTGPLSPsKDCGSPK		activity, inhibited				8391	2	6	0	MAPK1 mediated phosphorylatiion of Cx43 inducing inhibition of myometrial gap junctions.	
PTGER4	GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR	P35408	5734	PTGER4	5p13.1	human	S382	PHOSPHORYLATION	450698	GHSRSFIsRELKEIS		molecular association, regulation		ARRB1(INDUCES)		3068	1	0	0		
calpain 2	EC 3.4.22.53; Motility/polarity/chemotaxis; Protease	O08529	12334	Capn2		mouse	S50	PHOSPHORYLATION	451162	GALFQDPsFPALPSS	Peptidase_C2	intracellular localization				2455805	2	0	0		
Smad3	DNA binding protein; Nuclear receptor co-regulator; Transcription factor	P84022	4088	SMAD3	15q22.33	human	S425	PHOSPHORYLATION	448336	SIRCSSVs_______		activity, induced; protein conformation	cell motility, altered; transcription, altered			6277008; 1275	16	0	5	induce vascular invasion; The triple mutants(S422/423/425A and S422/423/425D) were used in these experiments 	
GBPI-1	Inhibitor protein; Protein phosphatase, regulatory subunit	Q9NXH3	54866	PPP1R14D	15q15.1	human	T58	PHOSPHORYLATION	450935	SRRPSRLtVKYDRGQ	PP1_inhibitor	phosphorylation				3043	1	0	0	Phosphorylated GBPI-1 inhibits PP1 activity.  Point mutant does not.	
PDX1	DNA binding protein; Transcription factor	P52947	29535	Pdx1		rat	S268	PHOSPHORYLATION	11279404	LPSGLSAsPQPSSIA		protein degradation				11189913	3	2	0		
EpoR	EC 2.7.10.2; Membrane protein, integral; Receptor, cytokine	P19235	2057	EPOR	19p13.3-p13.2	human	Y485	PHOSPHORYLATION	3103701	GGLSDGPySNPYENS			apoptosis, inhibited			8833	2	0	0		
Cx31	Channel, misc.; Membrane protein, integral; Membrane protein, multi-pass	P28231	14620	Gjb3		mouse	S263	PHOSPHORYLATION	2907501	ASEKLQAsAPSLTPI		activity, induced; protein stabilization				8408	1	1	0		
PLM	Cell surface; Channel, misc.; Membrane protein, integral	Q9Z239	56188	Fxyd1		mouse	S88	PHOSPHORYLATION	451425	RSSIRRLsSRRR___	IncA	intracellular localization				2610203	21	1	74	After stimulation with phorbol ester.	
PIK3R1	Enzyme, regulatory subunit; KINASE; Kinase, lipid; Motility/polarity/chemotaxis	P23727	282307	PIK3R1		cow	S83	PHOSPHORYLATION	471075	YIGRKKIsPPTPKPR		molecular association, regulation; phosphorylation; enzymatic activity, induced	cell cycle regulation; apoptosis, induced; apoptosis, inhibited	HRas(INDUCES); PKAR2B(INDUCES); ER-alpha(INDUCES)		8994; 9024	3	1	1	Phosphorylation affects survival in thyroid stimulating hormone or cAMP (S83A = reduced survival, S83D = reduced apoptosis).  S83A mutant slows S-G2/M progression, and reduces AKT phosphorylation.  Enzymatic activation in TSH (not via EGF); cAMP-induced protection from apoptosis was less efficient in S83A and more efficient in S83D.  S83A mutants do not arrest in G1 in presence of cAMP where as S83D accumulate in G1 (even in absence of cAMP).  cAMP-stimulated phosphorylation of this site leads to Akt1 and GSK3a activation, and binding to p21Ras and estrogen receptor.	
DAB1	Adaptor/scaffold	O75553	1600	DAB1	1p32-p31	human	Y232	PHOSPHORYLATION	447961	SQKKEGVyDVPKSQP		molecular association, regulation		Crk(INDUCES)		6167	12	4	12		
ICAM1	Cell adhesion; Immunoglobulin superfamily; Membrane protein, integral	P05362	3383	ICAM1	19p13.3-p13.2	human	Y501	PHOSPHORYLATION	450969	GTAGLSTyLYNRQRK	TM	protein processing				3234	1	0	0	proteolytic cleavage	
ATM	EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, ATYPICAL; Protein kinase, Ser/Thr (non-receptor)	Q13315	472	ATM	11q22-q23	human	S367	PHOSPHORYLATION	467198	DTRSLEIsQSYTTTQ		enzymatic activity, induced				17675019	3	5	1		
NMDAR2A	Channel, ligand-gated; Membrane protein, integral; Membrane protein, multi-pass	Q00959	24409	Grin2a		rat	S1232	PHOSPHORYLATION	448260	SGHFTMRsPFKCDAC	NMDAR2_C	activity, induced; intracellular localization				1358; 25712604	4	0	2	Glutamate treatment caused a translocation of p-S1232 from the cytosol to the plasma membrane.	
Nlp	Cell cycle regulation; Microtubule binding protein	Q9Y2I6	22981	NINL	20p11.22-p11.1	human	S585	PHOSPHORYLATION	15668108	RLPKNRHsPSWSPDG		intracellular localization	cell cycle regulation			15562527	1	0	0		
Casp8	Apoptosis; EC 3.4.22.-; EC 3.4.22.61; Protease	Q14790	841	CASP8	2q33-q34	human	S347	PHOSPHORYLATION	450983	FTGLKCPsLAGKPKV	Peptidase_C14	activity, inhibited	apoptosis, inhibited			3248	1	0	0		
EpoR	EC 2.7.10.2; Membrane protein, integral; Receptor, cytokine	P14753	13857	Epor		mouse	Y503	PHOSPHORYLATION	449885	SEPLHPGyVACS___		molecular association, regulation; receptor internalization, altered	apoptosis, altered; signaling pathway regulation	PLCG1(INDUCES); PIK3R2(INDUCES); PIK3R1(INDUCES)		6374; 18119106; 7397; 7454300	8	0	0	activates PI3K/Akt pathway in signaling by myeloproliferative disorder-associated Jak2 V617 mutant	
MRE11A	Cell cycle regulation; DNA binding protein; DNA repair; Deoxyribonuclease	P49959	4361	MRE11A	11q21	human	S590	PHOSPHORYLATION	11506401	NSASRGGsQRGRADT		molecular association, regulation			DNA(DISRUPTS)	11484420	1	0	0		
IGF1R	EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Protein kinase, TK; Protein kinase, tyrosine (receptor)	P08069	3480	IGF1R	15q26.3	human	S1312	PHOSPHORYLATION	2091901	LDPSASSsSLPLPDR		activity, induced; phosphorylation	apoptosis, altered; cell differentiation, altered; cell growth, altered			2703; 2727	2	1	0	observed in Y980F +  S1310-1313A; ERK phosphorylation	
GADD45GIP1	Cell cycle regulation; Nuclear receptor co-regulator	Q8TAE8	90480	GADD45GIP1	19p13.2	human	S221	PHOSPHORYLATION	474542	PAASGAPsS______			cell growth, altered			9243	1	0	0	promotes cell proliferation	
CTPS	EC 6.3.4.2; Ligase; Motility/polarity/chemotaxis; Nucleotide Metabolism - pyrimidine	P17812	1503	CTPS1	1p34.1	human	S575	PHOSPHORYLATION	449144	SDRSGSSsPDSEITE		molecular association, regulation		Pin1(INDUCES)		3301219	2	40	14		
FPR1	GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Motility/polarity/chemotaxis; Receptor, GPCR	P21462	2357	FPR1	19q13.4	human	T329	PHOSPHORYLATION	450665	RALTEDStQTSDTAT		receptor desensitization, altered; receptor internalization, altered				3130	2	0	0		
CHOP	Autophagy; DNA binding protein; Transcription factor	P35638	1649	DDIT3	12q13.1-q13.2	human	S14	PHOSPHORYLATION	455501	PFSFGTLsSWELEAW		activity, inhibited	transcription, inhibited			5475	1	0	0		
CYLD	EC 3.1.2.15; EC 3.4.19.12; Protease; Ubiquitin conjugating system; Ubiquitin-specific protease	Q9NQC7	1540	CYLD	16q12.1	human	S439	PHOSPHORYLATION	12173911	SIGHSPLsLSAQSVM		ubiquitination				12156302	1	0	0	induces ubiquitination of TRAF2	
IL2RB	Membrane protein, integral; Receptor, cytokine	P14784	3560	IL2RB	22q13.1	human	Y364	PHOSPHORYLATION	455360	SCFTNQGyFFFHLPD		molecular association, regulation	transcription, altered	Shc1(INDUCES)		8569; 4697; 4696; 2425221	3	0	0	mediated by PI3K pathway through Y364.	
hnRNP K	RNA binding protein; RNA splicing; Spliceosome	P61978	3190	HNRNPK	9q21.32-q21.33	human	S116	PHOSPHORYLATION	452369	EEGLQLPsPTATSQL		intracellular localization				17482905	2	19	14		
TrkA	EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Protein kinase, TK; Protein kinase, tyrosine (receptor)	P35739	59109	Ntrk1		rat	Y499	PHOSPHORYLATION	447762	HIMENPQyFSDTCVH		molecular association, regulation; enzymatic activity, induced	cell differentiation, altered; cell growth, altered	Shc2(INDUCES); Shc3(INDUCES)		5432; 7324106; 800	17	0	2		
G6f	Cell surface; Membrane protein, integral	Q5SQ64	259215	LY6G6F	6p21	human	Y281	PHOSPHORYLATION	450289	FKPEIQVyENIHLAR		molecular association, regulation; phosphorylation		GRB7(INDUCES); Grb2(INDUCES)		2929; 8280	3	2	9		
p21Cip1	Cell cycle regulation; Inhibitor protein	P38936	1026	CDKN1A	6p21.2	human	K141	UBIQUITINATION	9897002	PGDSQGRkRRQTSMT		protein degradation; ubiquitination				5669	2	0	0	UV-induced 	
P2X3	Channel, ligand-gated; Membrane protein, integral; Membrane protein, multi-pass	P56373	5024	P2RX3	11q12	human	T134	PHOSPHORYLATION	458895	LPGGGILtGRCVNYS	P2X_receptor	receptor desensitization, altered				7456	1	0	0		
Grb10	Adaptor/scaffold	Q13322	2887	GRB10	7p12.2	human	S104	PHOSPHORYLATION	483656	RSIQPQVsPRQRVQR		protein stabilization				19044700	1	8	1		
PKCE	EC 2.7.11.13; KINASE; Kinase, protein; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor)	Q02156	5581	PRKCE	2p21	human	Y573	PHOSPHORYLATION	764200	TFCGTPDyIAPEILQ	Pkinase	molecular association, regulation		PLCG1(INDUCES)		762704	1	1	0		
PHF20	Acetyltransferase; C2H2-type zinc finger protein; DNA binding protein; Nuclear envelope	Q9BVI0	51230	PHF20	20q11.22-q11.23	human	S291	PHOSPHORYLATION	23303200	ELRRRKIsKGCEVPL		intracellular localization	cell cycle regulation; cell growth, induced; apoptosis, inhibited; transcription, induced		DNA(NOT_REPORTED)	26349407; 23260365	2	0	0		
VEGFR2	EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Protein kinase, TK; Protein kinase, tyrosine (receptor)	P35968	3791	KDR	4q11-q12	human	Y801	PHOSPHORYLATION	450277	GGELKTGyLSIVMDP		activity, induced; molecular association, regulation; phosphorylation		PIK3R1(INDUCES)		2708101; 2986	4	1	3	PIK3R1, eNOS, and AKT phosphorylation; necessary for TNF but not VEGF activation of AKT;  stimulates NO2 release	
HER4	EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Protein kinase, TK; Protein kinase, tyrosine (receptor)	Q15303	2066	ERBB4	2q33.3-q34	human	Y1242	PHOSPHORYLATION	451502	KAFDNPDyWNHSLPP		molecular association, regulation		Shc1(INDUCES); Arg(INDUCES)		4651319; 3679	0	1	3		
KCNK18	Channel, ligand-gated; Channel, potassium; Membrane protein, integral; Membrane protein, multi-pass	Q6VV64	332396	Kcnk18		mouse	S279	PHOSPHORYLATION	13383301	RLSCSILsNLDEVGQ		activity, inhibited				13354719	2	0	0		
syndecan-1	Extracellular matrix; Membrane protein, integral; Motility/polarity/chemotaxis	P18828	20969	Sdc1		mouse	S286	PHOSPHORYLATION	469564	MKKKDEGsYSLEEPK	Syndecan; Glycophorin_A; Romo1	intracellular localization				8249	1	1	0		
SPAG5	Cell cycle regulation	Q96R06	10615	SPAG5	17q11.2	human	S974	PHOSPHORYLATION	1261100	EESLAEMsIMTTELQ		intracellular localization				1172873	1	0	0	required for SPAG5 localization to the spindle apparatus during mitosis	
Cdc25C	EC 3.1.3.48; Motility/polarity/chemotaxis; PHOSPHATASE; Protein phosphatase, dual-specificity	P30307	995	CDC25C	5q31	human	S168	PHOSPHORYLATION	449022	SEMKYLGsPITTVPK	M-inducer_phosp	enzymatic activity, inhibited	cell cycle regulation; cell adhesion, altered			13354721; 2459	4	5	59		
CD22	Cell surface; Membrane protein, integral	P35329	12483	Cd22		mouse	Y777	PHOSPHORYLATION	458398	AMDDTVSyAILRFPE		molecular association, regulation; activity, inhibited; phosphorylation		SHP-1(INDUCES)		1172849	4	0	1		
NMDAR2C	Channel, calcium; Channel, ligand-gated; Membrane protein, integral; Membrane protein, multi-pass	Q00961	24411	Grin2c		rat	S1083	PHOSPHORYLATION	7979604	GPRPRHAsLPSSVAE		molecular association, regulation; intracellular localization		14-3-3 epsilon(INDUCES)		7890601	1	0	0		
Ku70	DNA binding protein; DNA repair; EC 3.6.4.-; EC 4.2.99.-; Helicase	P23475	14375	Xrcc6		mouse	S49	PHOSPHORYLATION	10211800	ASRAMFEsQGEDELT	Ku_N	molecular association, regulation		Bax(DISRUPTS)		9985907	2	0	0	kainate treatment increases interaction of Ku70 with Bax	
Cx43	Channel, misc.; Membrane protein, integral; Membrane protein, multi-pass; Motility/polarity/chemotaxis	P23242	14609	Gja1		mouse	S364	PHOSPHORYLATION	450183	AIVDQRPsSRASSRA		intracellular localization; protein conformation				12232	5	5	0	S363, S364 phosphorylation prevent an antibody to the Cx43 C-terminus.  	
E2F1	DNA binding protein; Transcription factor	Q01094	1869	E2F1	20q11.2	human	T433	PHOSPHORYLATION	447871	DCDFGDLtPLDF___		protein degradation; intracellular localization	cell differentiation, altered			4641422; 1338	3	0	0		
JAM2	Cell adhesion; Membrane protein, integral	Q9JI59	67374	Jam2		mouse	S280	PHOSPHORYLATION	11263901	FQKGSPAsKVTTMSE		intracellular localization				10296908	1	0	0	S280A mutant localized at cell-cell contacts	
LIP8	Cell cycle regulation	Q8N137	116840	CNTROB	17p13.1	human	S41	PHOSPHORYLATION	27565613	VTSQLYAsLRLSRQA			cell motility, inhibited			27565307	1	0	0		
tau iso8	Cytoskeletal protein	P10636-8	4137	MAPT	17q21.1	human	S404	PHOSPHORYLATION	449082	PVVSGDTsPRHLSNV		O-GlcNAc glycosylation; molecular association, regulation; intracellular localization; protein processing; protein conformation; phosphorylation	cytoskeletal reorganization	TUBA4A(DISRUPTS); TUBA1A(DISRUPTS); TUBB(DISRUPTS); tau iso8(INDUCES)		3475711; 4578; 5955607; 2365406; 8165400; 3579; 5955603; 7663; 6115906; 5955604	87	31	69	The amount of tau in partticulate fraction increased in R406W and V337M mutants compared to WT.; Mutant pseudo-phosphorylation at S396 and S404 or truncation at the C terminus induces tau filament assembly in vitro.	
MEKK3	EC 2.7.11.25; KINASE; Kinase, protein; Protein kinase, STE; Protein kinase, Ser/Thr (non-receptor)	Q99759	4215	MAP3K3	17q23.3	human	T294	PHOSPHORYLATION	2243102	DYSDGRRtFPRIRRH		molecular association, regulation		14-3-3 beta(INDUCES)		2195468	1	0	0	facilitated by phosphorylation of S526	
FHIT	DNA replication; EC 3.6.1.29; Hydrolase; Motility/polarity/chemotaxis; Nucleotide Metabolism - purine; Tumor suppressor	P49789	2272	FHIT	3p14.2	human	Y114	PHOSPHORYLATION	447802	FHRNDSIyEELQKHD		protein degradation; intracellular localization; enzymatic activity, inhibited; activity, inhibited	cell cycle regulation; apoptosis, altered; apoptosis, induced; cell growth, altered	HSP60(INDUCES); FDXR(INDUCES)		6702312; 1903014; 2626211; 5565	4	1	0	localization to the mitochondria; Overepression of wt FHIT promotes apoptosis but not the Y113A or Y113F mutation.  	
PU.1	DNA binding protein; Transcription factor	Q6BDS1		Spi1		rat	S147	PHOSPHORYLATION	455900	QSPPLEVsDGEADGL		molecular association, regulation		IRF8(INDUCES)		8588	5	1	0		
gp130	Membrane protein, integral; Receptor, cytokine	P40189	3572	IL6ST	5q11.2	human	T890	PHOSPHORYLATION	455688	GQVERFEtVGMEAAT		molecular association, regulation				5852	1	0	1		
RPE65	Cofactor and Vitamin Metabolism - retinol; EC 3.1.1.64; EC 5.2.1.7	Q16518	6121	RPE65	1p31	human	C112	PALMITOYLATION	12559508	TCAFPDPcKNIFSRF	RPE65	intracellular localization; enzymatic activity, induced				12482408	1	1	0	membrane localization	
PrlR	Membrane protein, integral; Receptor, cytokine	P16471	5618	PRLR	5p13.2	human	T415	PHOSPHORYLATION	449611	AGGSKCStWPLPQPS		molecular association, regulation; phosphorylation	transcription, altered	14-3-3 zeta(INDUCES); 14-3-3 gamma(INDUCES)		2252	1	0	0	phosphorylation reduces tyrosine phosphorylation after prolactin stimulation as well as activation of ERK and AKT	
PECAM-1	Cell adhesion; Membrane protein, integral	Q08481	18613	Pecam1		mouse	Y702	PHOSPHORYLATION	448760	TRATETVySEIRKVD		molecular association, regulation	cell adhesion, altered	SHP-2(INDUCES); SHP-1(INDUCES)		12482202; 2036	11	13	799	Y702 A.K.A. Y686; induces switch from heterophilic to homophilic cell-cell aggregation	
Jun	Transcription factor	P05412	3725	JUN	1p32-p31	human	T231	PHOSPHORYLATION	455366	ALKEEPQtVPEMPGE	Jun; DUF3450	molecular association, regulation; activity, inhibited	transcription, altered	SP1(DISRUPTS)		4702; 2713706	3	0	0		
RhoGDI alpha	Apoptosis; Cell adhesion; Cell development/differentiation; G protein regulator, misc.; Motility/polarity/chemotaxis	Q5XI73	360678	Arhgdia		rat	S101	PHOSPHORYLATION	452195	LESFKKQsFVLKEGV	Rho_GDI	molecular association, regulation	cell growth, altered	RAC1(DISRUPTS); Cdc42 iso1(DISRUPTS)		6829223	3	4	1	in response to bFGF stimulation	
STAT2	DNA binding protein; Transcription factor	P52630	6773	STAT2	12q13.3	human	Y690	PHOSPHORYLATION	448193	NLQERRKyLKHRLIV		intracellular localization				6284	9	0	0		
SNAP23	Vesicle protein	O70377	64630	Snap23		rat	S160	PHOSPHORYLATION	4148814	ENLTQVGsILGNLKN	Use1; Fib_alpha; RmuC; Tropomyosin; SNARE		exocytosis, altered			15785207	2	9	14		
DAB1 iso3	Adaptor/scaffold	P97318-3	13131	Dab1		mouse	S246	PHOSPHORYLATION	479425	PVSSLVQsPAAERAE		protein degradation; phosphorylation				11449	1	0	0	enhances tyrosine phosphorylation and protein degradation	
AS160	GTPase activating protein, Rab	Q8BYJ6	210789	Tbc1d4		mouse	S758	PHOSPHORYLATION	455924	EGRKRTSsTCSNESL		phosphorylation				11390405	9	6	48	TBC1D4 S318/S588/T642/S751A mutation decreases phosphorylation of S711	
Dok2	Adaptor/scaffold	O70469	13449	Dok2		mouse	Y276	PHOSPHORYLATION	452174	LPRPESPySRPHDSL		molecular association, regulation	cell differentiation, altered; cell growth, altered	RASA1(INDUCES)		5379; 7309801; 4091	3	0	1		
MafA	DNA binding protein; Transcription factor	Q8NHW3	389692	MAFA	8q24.3	human	T57	PHOSPHORYLATION	456028	LSSTPLStPCSSVPS		protein degradation				7910506	6	1	0		
GRK7	EC 2.7.1.-; EC 2.7.11.14; EC 2.7.11.16; KINASE; Kinase, protein; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor)	Q8WTQ7	131890	GRK7	3q24	human	S36	PHOSPHORYLATION	456355	ELQRRRRsLALPGLQ		enzymatic activity, inhibited				6682	2	0	0	reaction in vitro	
C3aR	GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR	Q16581	719	C3AR1	12p13.31	human	S465	PHOSPHORYLATION	27145808	FSEELTRsTHCPSNN		receptor internalization, induced; molecular association, regulation	transcription, inhibited	ARRB1(INDUCES)		27132477	1	0	0		
Trad	EC 2.7.11.1; Guanine nucleotide exchange factor, Rac/Rho; KINASE; Kinase, protein; Protein kinase, CAMK; Protein kinase, Ser/Thr (non-receptor)	P97924	84009	Kalrn		rat	T77	PHOSPHORYLATION	1315601	DVCKRGFtVIIDMRG	CRAL_TRIO_2	activity, induced	cytoskeletal reorganization			1172853	1	0	0	regulates neuronal spines and Rac1 activation	
MCTS1		Q9ULC4	28985	MCTS1	Xq24	human	T81	PHOSPHORYLATION	26348501	REGPFYPtLRLLHKY			cell growth, induced			25785407	1	0	0		
EphA8	EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Protein kinase, TK; Protein kinase, tyrosine (receptor)	O09127	13842	Epha8		mouse	Y838	PHOSPHORYLATION	448559	LAYGERPyWNMTNQD	Pkinase_Tyr	enzymatic activity, induced	cell adhesion, altered			1651	1	0	0	Y383 phosphorylation is required for efficient phosphorylation of Y615 and other major sites.	
ATM	EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, ATYPICAL; Protein kinase, Ser/Thr (non-receptor)	Q13315	472	ATM	11q22-q23	human	S2996	PHOSPHORYLATION	7433302	QECKRNLsDIDQSFN		enzymatic activity, induced				17675019	1	6	0		
ELK4	DNA binding protein; Transcription, coactivator/corepressor	P41158	13714	Elk4		mouse	S386	PHOSPHORYLATION	4317601	LSPFAPLsPARLQGA			cell growth, altered			4317100	2	0	0	pro-B cell expansion	
CDK2	EC 2.7.11.22; KINASE; Kinase, protein; Protein kinase, CMGC; Protein kinase, Ser/Thr (non-receptor)	P97377	12566	Cdk2		mouse	Y15	PHOSPHORYLATION	447740	EKIGEGTyGVVYKAK	Pkinase	enzymatic activity, inhibited	cell growth, altered			6547	27	72	3817		
Cdc25A	EC 3.1.3.48; Motility/polarity/chemotaxis; PHOSPHATASE; Protein phosphatase, dual-specificity	P30304	993	CDC25A	3p21	human	S18	PHOSPHORYLATION	449976	RRLLFACsPPPASQP		protein stabilization	cell cycle regulation	CDK1(INDUCES)		2535	3	3	0		
CTNNB1	Actin binding protein; Cell adhesion; Motility/polarity/chemotaxis; Nuclear receptor co-regulator; Transcription factor	P35222	1499	CTNNB1	3p21	human	S45	PHOSPHORYLATION	447488	GATTTAPsLSGKGNP		protein degradation; molecular association, regulation; intracellular localization; phosphorylation	cell motility, altered; cell adhesion, altered	CBLL1(INDUCES); axin 1(INDUCES); CDH1(INDUCES)		1732; 7613718; 1992305; 14654301; 2230	21	5	0	may play role in invasive breast cancer	
E2F1	DNA binding protein; Transcription factor	Q01094	1869	E2F1	20q11.2	human	S364	PHOSPHORYLATION	449403	PLLSRMGsLRAPVDE		protein stabilization; intracellular localization	apoptosis, induced; transcription, induced			2206	3	0	0		
FOXO6	DNA binding protein	Q70KY4	329934	Foxo6		mouse	S184	PHOSPHORYLATION	2899100	TPRRRAVsMDNGAKF	Fork_head	molecular association, regulation; intracellular localization	transcription, altered; transcription, inhibited		DNA(DISRUPTS)	8511; 12482251	2	0	0		
USF1	DNA binding protein; Transcription factor	Q61069	22278	Usf1		mouse	K235	ACETYLATION	7378203	DCSMESTkSGQSKGG	HLH		transcription, altered			7303912	2	1	0		
MST2	Autophagy; EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, STE; Protein kinase, Ser/Thr (non-receptor)	Q9JI10	56274	Stk3		mouse	Y81	PHOSPHORYLATION	25528501	MQQCDSPyVVKYYGS	Pkinase	molecular association, regulation	apoptosis, induced	MST2(INDUCES); RAF1(DISRUPTS)		25347035	1	1	0		
KATNA1	EC 3.6.4.3; Hydrolase; Motility/polarity/chemotaxis	O75449	11104	KATNA1	6q25.1	human	S109	PHOSPHORYLATION	23117380	VPVERRPsPGPRKRQ		ubiquitination	cell cycle regulation			25779408	1	1	1		
CACNA1C	Channel, calcium; Membrane protein, integral; Membrane protein, multi-pass	P15381	100101555	CACB		rabbit	S533	PHOSPHORYLATION	453091	RISKSKFsRYWRRWN		activity, inhibited				3203	3	0	0		
PTEN	Carbohydrate Metabolism - inositol phosphate; EC 3.1.3.16; EC 3.1.3.48; EC 3.1.3.67; Motility/polarity/chemotaxis; Nuclear receptor co-regulator; PHOSPHATASE; Phosphatase, lipid; Tumor suppressor	P60484	5728	PTEN	10q23.3	human	S385	PHOSPHORYLATION	448650	RYSDTTDsDPENEPF		protein stabilization; enzymatic activity, inhibited		PTEN(INDUCES); PTEN(DISRUPTS)		1252602; 5121518; 2904	7	7	0		
axin 1	Adaptor/scaffold	O15169	8312	AXIN1	16p13.3	human	S77	PHOSPHORYLATION	3174926	YEPEGSAsPTPPYLK			transcription, inhibited	GSK3B(INDUCES)		25785410	1	7	9		
CLCN1	Channel, chloride; Membrane protein, integral; Membrane protein, multi-pass	P35523	1180	CLCN1	7q35	human	T893	PHOSPHORYLATION	14645301	SFRNTTStRKSTGAP		activity, induced				14551407	1	0	1		
ERK2	EC 2.7.11.24; KINASE; Kinase, protein; Protein kinase, CMGC; Protein kinase, Ser/Thr (non-receptor)	P63085	26413	Mapk1		mouse	T183	PHOSPHORYLATION	447593	HDHTGFLtEYVATRW	Pkinase; YukC	enzymatic activity, induced	transcription, altered	Gab1(INDUCES)		1818; 4222; 4862602; 5209; 5766; 6759; 6947; 5354414; 9199; 914	954	60	2332		
RhoB	G protein; G protein, monomeric, Rho; Motility/polarity/chemotaxis	P62745	388	RHOB	2p24	human	S185	PHOSPHORYLATION	2853110	ALQKRYGsQNGCINC		molecular association, regulation; activity, inhibited	cytoskeletal reorganization	PKN1(DISRUPTS)		2831747	1	0	0		
PXN	Adaptor/scaffold; Cell adhesion; Cytoskeletal protein; Motility/polarity/chemotaxis	Q8VI36	19303	Pxn		mouse	S83	PHOSPHORYLATION	451113	YAHQQPPsPLPVYSS	Paxillin	activity, induced; molecular association, regulation	cell differentiation, altered; cell motility, altered; cytoskeletal reorganization	ERK1(INDUCES); FAK(INDUCES)		4239	7	24	36		
SSTR3	GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR	P30936	171044	Sstr3		rat	S341	PHOSPHORYLATION	456708	RRILLRPsRRVRSQE		receptor desensitization, altered; receptor internalization, altered				4062	1	0	2		
PLCG1	Carbohydrate Metabolism - inositol phosphate; EC 3.1.4.11; Motility/polarity/chemotaxis; Phospholipase	P10686	25738	Plcg1		rat	Y509	PHOSPHORYLATION	464036	NHEWYPHyFVLTSSK	PH	enzymatic activity, inhibited; phosphorylation				13796704	3	0	8	Y509A/F510A mutant PLCG1 has enhanced phosphorylation of Y783, but no longer requires Y783 phosphorylation for enzymatic activation 	
PLK4	EC 2.7.11.21; KINASE; Kinase, protein; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor)	Q64702	20873	Plk4		mouse	S282	PHOSPHORYLATION	12654003	DVGTVEDsMDSGHAT		protein degradation; ubiquitination				12525201	1	1	0		
NUP98 iso2	Motility/polarity/chemotaxis; Nucleoporin	P52948-2	4928	NUP98	11p15.5	human	S591	PHOSPHORYLATION	470431	VLKNLNNsNLFSPVN		intracellular localization				18331300	1	15	2	as multiple sites (13PM) mutant 	
eEF1D	Translation; Translation elongation	P29692	1936	EEF1D	8q24.3	human	S133	PHOSPHORYLATION	455672	APQTQHVsPMRQVEP	DUF4349; Reo_sigmaC; Striatin	phosphorylation				6177	1	58	49		
FOXO3A	Autophagy; DNA binding protein; Transcription factor	O43524	2309	FOXO3	6q21	human	S294	PHOSPHORYLATION	472326	QLSKWPGsPTSRSSD		protein degradation; molecular association, regulation; activity, inhibited	cell growth, altered	MDM2(INDUCES)		1968337	4	8	65	promotes tumorigenicity	
ITK	EC 2.7.10.2; KINASE; Kinase, protein; Protein kinase, TK; Protein kinase, tyrosine (non-receptor)	Q03526	16428	Itk		mouse	Y186	PHOSPHORYLATION	449834	ETLVIALyDYQTNDP	SH3_1	phosphorylation				2933	2	0	79	Itk Y186F retains partial activity;  stimulates ERK phosphorylation	
TRPV6	Channel, calcium; Membrane protein, integral; Membrane protein, multi-pass	Q9H1D0	55503	TRPV6	7q34	human	T688	PHOSPHORYLATION	12173902	MPSVSRStSRSSANW		activity, inhibited				12021338	1	0	0	involved in regulation of calcium influx by ATP 	
TNNT2	Motility/polarity/chemotaxis; Motor protein	P50752	21956	Tnnt2		mouse	T207	PHOSPHORYLATION	449038	YIQKQAQtERKSGKR	Troponin	activity, induced				8407	3	0	0		
MED1	Nuclear receptor co-regulator; Transcription, coactivator/corepressor	Q925J9	19014	Med1		mouse	T1032	PHOSPHORYLATION	458308	SSSNRPFtPPTSTGG			transcription, induced			2425236	3	0	1		
FOXO1A	DNA binding protein; Nuclear receptor co-regulator; Transcription factor	Q9R1E0	56458	Foxo1		mouse	S319	PHOSPHORYLATION	449112	PRTSSNAsTISGRLS			transcription, inhibited			4910502	6	1	0		
BAD	Apoptosis	Q92934	572	BAD	11q13.1	human	S91	PHOSPHORYLATION	447861	EGMGEEPsPFRGRSR	Bcl-2_BAD		transcription, altered	BAD(DISRUPTS)		1252601	7	6	19	Mutation of S91 to S91A inhibits luciferase activity compared to WT.  	
ENG	Membrane protein, integral; Motility/polarity/chemotaxis; Receptor, misc.	P17813	2022	ENG	9q34.11	human	S634	PHOSPHORYLATION	465618	VAVAAPAsSESSSTN	DUF4199	phosphorylation				8075	1	1	0	required for threonine phosphorylation of ENG	
PPAR-alpha	DNA binding protein; Nuclear receptor	P37230	25747	Ppara		rat	S163	PHOSPHORYLATION	22342300	CRFHKCLsVGMSHNA	zf-C4	intracellular localization	transcription, induced			21686203	1	0	0		
calsequestrin 2	Calcium-binding protein	P12637	483134	CASQ2		dog	S397	PHOSPHORYLATION	451464	DDDDGNNsDEESNDD		intracellular localization				18759800	3	2	0	regulates intracellular trafficking of calsequestrin 2	
AQP2	Channel, misc.; Membrane protein, integral; Membrane protein, multi-pass	P34080	25386	Aqp2		rat	S269	PHOSPHORYLATION	3339002	PQSLPRGsKA_____		intracellular localization	endocytosis, inhibited			27981100; 13159708; 25608318	12	3	0		
KCC3	Membrane protein, integral; Membrane protein, multi-pass; Transporter	Q9UHW9	9990	SLC12A6	15q13	human	T991	PHOSPHORYLATION	4770536	SAYTYERtLMMEQRS		activity, inhibited				9985929	2	6	0		
IL21R	Membrane protein, integral; Receptor, cytokine	Q9JHX3	60504	Il21r		mouse	Y281	PHOSPHORYLATION	1270907	ESFFQPLyREHSGNF			cell growth, altered			9299	1	0	0		
NR2C1	DNA binding protein; Nuclear receptor	Q505F1	22025	Nr2c1		mouse	S185	PHOSPHORYLATION	457682	IEVSREKsSNCAAST		molecular association, regulation		PCAF(INDUCES)		7297	1	0	0	this interaction is enhanced by S170 phosphorylation	
IRS1	Adaptor/scaffold; Motility/polarity/chemotaxis	P35569	16367	Irs1		mouse	S635	PHOSPHORYLATION	447507	YMPMSPKsVSAPQQI		protein degradation				6804	27	3	0		
EXOSC9	EC 3.1.13.-; RNA processing; Ribonuclease	Q06265	5393	EXOSC9	4q27	human	S394	PHOSPHORYLATION	3194468	APIILSDsEEEEMII		molecular association, regulation		SUMO2(INDUCES); SUMO1(INDUCES)		6829202	1	9	1		
CTNND2	Actin binding protein; Motility/polarity/chemotaxis	O35927	18163	Ctnnd2		mouse	S300	PHOSPHORYLATION	14910701	RGSSPKQsPSRLAKS		molecular association, regulation; intracellular localization	cytoskeletal reorganization	PSD-95(DISRUPTS); GRIP1(DISRUPTS)		14780512	1	1	1		
GLRA3	Membrane protein, integral; Membrane protein, multi-pass	Q91XP5	110304	Glra3		mouse	S379	PHOSPHORYLATION	1848000	TDDEVREsRFSFTAY	Neur_chan_memb	receptor desensitization, altered; activity, inhibited				1713106	2	1	0		
CAD	Amino Acid Metabolism - alanine, aspartate and glutamate; EC 2.1.3.2; EC 3.5.2.3; EC 6.3.5.5; Hydrolase; KINASE; Ligase; Nucleotide Metabolism - pyrimidine; Transferase	P08955	101843763	Cad		hamster	T456	PHOSPHORYLATION	451248	KVYFLPItPHYVTQV	CPSase_L_chain	enzymatic activity, induced				3471	6	0	0		
ATP7A	Apoptosis; Cell development/differentiation; Chaperone; EC 3.6.3.4; Hydrolase; Membrane protein, integral; Membrane protein, multi-pass; Transporter; Vesicle protein	Q04656	538	ATP7A	Xq21.1	human	S1469	PHOSPHORYLATION	9768107	ASINSLLsDKRSLNS		intracellular localization				9721215	1	2	0	required for post-Golgi exocytic trafficking (Cu -responsive)	
ANPA	EC 4.6.1.2; Guanylyl cyclase; KINASE; Kinase, protein; Lyase; Membrane protein, integral; Nucleotide Metabolism - purine; Protein kinase, RGC; Protein kinase, dual-specificity; Receptor, misc.	P16066	4881	NPR1	1q21-q22	human	T532	PHOSPHORYLATION	447513	RSAGSRLtLSGRGSN		activity, induced				896	2	3	1		
CBP	ACETYLTRANSFERASE; Acetyltransferase; DNA binding protein; EC 2.3.1.48; Motility/polarity/chemotaxis; Nuclear receptor co-regulator; Transcription, coactivator/corepressor	Q92793	1387	CREBBP	16p13.3	human	Y659	PHOSPHORYLATION	447690	HLLAEKIyKIQKELE	KIX	molecular association, regulation	transcription, altered	Myb(INDUCES); CBP(INDUCES)		1461	2	1	0	 	
PTRH2	EC 3.1.1.29; Hydrolase; Mitochondrial	Q9Y3E5	51651	PTRH2	17q23.1	human	S5	PHOSPHORYLATION	4206801	___MPSKsLVMEYLA		intracellular localization	apoptosis, altered; cell adhesion, altered			4042515	1	0	0	associated with anoikis (cell death induced by detachment from the extracellular matrix)	
HER4	EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Protein kinase, TK; Protein kinase, tyrosine (receptor)	Q15303	2066	ERBB4	2q33.3-q34	human	Y1081	PHOSPHORYLATION	4825103	EQGVSVPyRAPTSTI		molecular association, regulation		Arg(INDUCES); Crk(INDUCES)		4651319	0	1	0		
AML3	DNA binding protein; Transcription factor	Q13950	860	RUNX2	6p21	human	T198	PHOSPHORYLATION	27728402	SGRGKSFtLTITVFT	Runt	molecular association, regulation	transcription, induced		DNA(INDUCES)	27623402	1	0	0	induction of MMP3 and MMP9 transcription, invasion of breast cancer cells	
Bcl-11B	C2H2-type zinc finger protein; Nuclear receptor co-regulator	Q99PV8	58208	Bcl11b		mouse	T260	PHOSPHORYLATION	3828640	GPASTSLtPRLTIPP		molecular association, regulation		SENP1(INDUCES)		25573548	0	6	49		
ANPB	EC 4.6.1.2; Guanylyl cyclase; KINASE; Kinase, protein; Lyase; Membrane protein, integral; Nucleotide Metabolism - purine; Protein kinase, RGC; Protein kinase, dual-specificity; Receptor, misc.	P16067	116564	Npr2		rat	S513	PHOSPHORYLATION	450027	RYHKGAGsRLTLSLR		activity, induced				2568	2	1	0		
RSK4	EC 2.7.1.37; EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor)	Q9UK32	27330	RPS6KA6	Xq21	human	S232	PHOSPHORYLATION	457600	DQEKKAYsFCGTVEY	Pkinase	enzymatic activity, induced				7130	1	20	132		
SP3	C2H2-type zinc finger protein; DNA binding protein	Q02447	6670	SP3	2q31	human	S73	PHOSPHORYLATION	1199100	CSKIGPPsPGDDEEE		activity, induced; protein stabilization	transcription, induced			1172804	1	12	0		
Kv2.1	Channel, cation; Channel, ligand-gated; Channel, potassium; Membrane protein, integral; Membrane protein, multi-pass	P15387	25736	Kcnb1		rat	S15	PHOSPHORYLATION	473559	HGSRSTSsLPPEPME		activity, inhibited				9216	2	5	1		
Shc3	Adaptor/scaffold; Motility/polarity/chemotaxis	Q92529	53358	SHC3	9q22.1	human	Y342	PHOSPHORYLATION	451258	DGSDHPYyNSIPSKM			apoptosis, inhibited			6002	3	2	8		
TrkA	EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Protein kinase, TK; Protein kinase, tyrosine (receptor)	P04629	4914	NTRK1	1q21-q22	human	Y680	PHOSPHORYLATION	447763	RDIYSTDyYRVGGRT	Pkinase_Tyr	receptor internalization, altered; enzymatic activity, induced				5955616	9	2	10		
CTNNB1	Actin binding protein; Cell adhesion; Motility/polarity/chemotaxis; Nuclear receptor co-regulator; Transcription factor	Q02248	12387	Ctnnb1		mouse	Y654	PHOSPHORYLATION	447585	RNEGVATyAAAVLFR	Arm	molecular association, regulation; intracellular localization	cell motility, altered; cell adhesion, altered; cytoskeletal reorganization; transcription, altered	TCF4(INDUCES); TBP(INDUCES); Smad2(INDUCES); CDH1(DISRUPTS)		6842214; 2546; 1733; 7613745	14	3	21	nuclear accumulation in ideopathic pulmonary fibrosis (IPF) in lung; necessary for localization to the nucleus after UV irradiation	
KIF2C	Cancer Testis Antigen (CTA); Microtubule binding protein; Motility/polarity/chemotaxis; Motor protein	Q99661	11004	KIF2C	1p34.1	human	S115	PHOSPHORYLATION	2132104	RSRSTRMsTVSELRI		intracellular localization; activity, inhibited	cytoskeletal reorganization			3306	1	1	8		
IRF3	DNA binding protein; Transcription factor	Q14653	3661	IRF3	19q13.3-q13.4	human	S398	PHOSPHORYLATION	449029	VDLHISNsHPLSLTS		activity, induced; molecular association, regulation; intracellular localization	transcription, altered	IRF3(INDUCES); CBP(INDUCES)		3416; 2062; 6337817; 2195490	6	1	0		
Notch 1	Membrane protein, integral; Motility/polarity/chemotaxis; Receptor, misc.; Transcription factor	Q01705	18128	Notch1		mouse	K1770	ACETYLATION	18899512	FKVSEASkKKRREPL		protein stabilization; ubiquitination				18899000	1	1	0		
AML1 iso8	DNA binding protein; Transcription factor	Q01196-8	861	RUNX1	21q22.3	human	S424	PHOSPHORYLATION	1308915	SMVGGERsPPRILPP	RunxI	molecular association, regulation	cell growth, altered	HDAC1(DISRUPTS); HDAC3(DISRUPTS)		17431513	2	0	2	increases marrow progenitor proliferation	
NKX3-1	DNA binding protein; Transcription factor	Q99801	4824	NKX3-1	8p21.2	human	S195	PHOSPHORYLATION	4913200	LGDLEKHsSLPALKE		protein degradation; ubiquitination				4641410	2	0	0		
NEDD4L	EC 6.3.2.-; EC 6.3.2.19; Ligase; UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase	Q96PU5	23327	NEDD4L	18q21	human	S448	PHOSPHORYLATION	453440	IRRPRSLsSPTVTLS		molecular association, regulation; phosphorylation		Smad3(DISRUPTS); ENaC-alpha(DISRUPTS); ENaC-beta(DISRUPTS); 14-3-3 eta(INDUCES); ENaC-alpha(INDUCES)		5509; 4138; 12343103; 2865418; 4207	10	29	50		
eEF2K	EC 2.7.11.20; KINASE; Kinase, protein; Protein kinase, ATYPICAL; Protein kinase, Ser/Thr (non-receptor); Translation	O00418	29904	EEF2K	16p12.2	human	S78	PHOSPHORYLATION	450687	SSGSPANsFHFKEAW		molecular association, regulation; enzymatic activity, inhibited; enzymatic activity, induced	cell growth, induced	calmodulin(DISRUPTS)		8434; 27127701	5	4	0		
geminin	Cell cycle regulation; Motility/polarity/chemotaxis	O75496	51053	GMNN	6p22.3	human	S202	PHOSPHORYLATION	475944	AEGTVSSsTDAKPCI	Fmp27_WPPW		apoptosis, altered			9237	1	0	0	regulates geminin cleavage by caspase-3	
PAK1	EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, STE; Protein kinase, Ser/Thr (non-receptor)	Q13153	5058	PAK1	11q13-q14	human	Y153	PHOSPHORYLATION	463955	TDKSAEDyNSSNALN		enzymatic activity, induced	apoptosis, altered; cell motility, induced; cell motility, altered			27519665; 12246	4	1	22	membrane ruffling;  closure of wounded monolayer; JAK2 tyrosine phosphorylation of PAK1 protects against apoptosis, and is required for maximal cell motility. 	
HMGB1	DNA repair; Nuclear receptor co-regulator	P09429	3146	HMGB1	13q12	human	S39	PHOSPHORYLATION	7320388	PDASVNFsEFSKKCS	Nop14; DUF1898; Nucleo_P87	intracellular localization	cell motility, altered			9201014	3	3	2	increases tumor cell invasiveness	
p70S6K	EC 2.7.11.-; EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor); Translation	Q8BSK8	72508	Rps6kb1		mouse	T412	PHOSPHORYLATION	448607	NQVFLGFtYVAPSVL	Pkinase_C	molecular association, regulation; ubiquitination; enzymatic activity, induced	cell cycle regulation	DEDD(INDUCES)		1173002; 7119509; 17613017	301	1	1		
Smad3	DNA binding protein; Nuclear receptor co-regulator; Transcription factor	P84022	4088	SMAD3	15q22.33	human	S416	PHOSPHORYLATION	3193766	KVLTQMGsPSIRCSS		intracellular localization				6841100	1	1	0	nuclear translocation	
Lck	EC 2.7.10.2; KINASE; Kinase, protein; Protein kinase, TK; Protein kinase, tyrosine (non-receptor)	P06239	3932	LCK	1p34.3	human	S59	PHOSPHORYLATION	447820	EGSNPPAsPLQDNLV		molecular association, regulation		SQSTM1(INDUCES)		2645; 1148	7	1	5		
Fos	DNA binding protein; Motility/polarity/chemotaxis; Transcription factor	P01101	14281	Fos		mouse	S362	PHOSPHORYLATION	448481	AAAHRKGsSSNEPSS		molecular association, regulation; protein stabilization		ER-beta(INDUCES)		5194; 21402211	10	2	1		
IKK-gamma	Adaptor/scaffold; Protein kinase, regulatory subunit	Q9Y6K9	8517	IKBKG	Xq28	human	K285	UBIQUITINATION	486356	QEVIDKLkEEAEQHK		activity, induced				19075405	5	2	12	activation by genotoxic stress	
GSK3A	EC 2.7.11.1; EC 2.7.11.26; KINASE; Kinase, protein; Protein kinase, CMGC; Protein kinase, Ser/Thr (non-receptor)	Q2NL51	606496	Gsk3a		mouse	S21	PHOSPHORYLATION	448584	SGRARTSsFAEPGGG		protein degradation; enzymatic activity, inhibited	apoptosis, induced; cytoskeletal reorganization; transcription, altered; cell growth, altered			4914015; 6842224; 4904523	122	11	274	Phosphorylation inhibits cardiac hypertrophy.	
Kv4.3	Channel, potassium; Membrane protein, integral; Membrane protein, multi-pass	Q62897	65195	Kcnd3		rat	S535	PHOSPHORYLATION	3681504	YPSTRSPsLSSHSGL	DUF3399	activity, inhibited				3309527	1	1	0		
KCNMA1	Channel, potassium; Endoplasmic reticulum; Membrane protein, integral; Membrane protein, multi-pass	Q08460	16531	Kcnma1		mouse	Y831	PHOSPHORYLATION	11502400	VFVGSIEyLKREWET		activity, induced				11419360	1	0	0		
Mena iso4	Adaptor/scaffold; Motility/polarity/chemotaxis	Q03173-4	13800	Enah		mouse	S236	PHOSPHORYLATION	451465	WERERRMsNAAPSSD	CAF-1_p150		cell motility, altered; cytoskeletal reorganization; cell growth, altered			2157400; 3656	3	2	15		
Akt1	EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor)	P47196	24185	Akt1		rat	S473	PHOSPHORYLATION	447855	RPHFPQFsYSASGTA	Pkinase_C	activity, induced; molecular association, regulation; intracellular localization; enzymatic activity, induced	cell differentiation, altered; apoptosis, inhibited	RAF1(INDUCES)		13789000; 9093; 6094; 4647107; 6328000; 8082; 6549; 4646612; 5573; 5718; 6057	1158	5	43	AKAP12 supression induced S473 phosphorylation.	
syndecan-2	Cell adhesion; Cell surface; Membrane protein, integral; Motility/polarity/chemotaxis	P34900	25615	Sdc2		rat	Y191	PHOSPHORYLATION	448376	RKPSSAAyQKAPTKE	Glycophorin_A; Herpes_gE; Syndecan	molecular association, regulation	cytoskeletal reorganization	EphB2(INDUCES)		1468	1	4	6		
APP	Apoptosis; Cell surface; Membrane protein, integral; Receptor, misc.; Transcription factor	P08592	54226	App		rat	T743	PHOSPHORYLATION	448523	VEVDAAVtPEERHLS	APP_amyloid	protein degradation				3095	30	2	3	T743 phosphorylation directly impacts on APP cleavage	
LC8	Microtubule binding protein; Motility/polarity/chemotaxis; Motor protein	P63167	8655	DYNLL1	12q24.23	human	S88	PHOSPHORYLATION	454241	VAILLFKsG______	Dynein_light; TraH	molecular association, regulation; protein conformation; phosphorylation	cell cycle regulation; cell differentiation, altered; apoptosis, altered; apoptosis, inhibited; cell growth, altered	LC8(DISRUPTS); Bim(DISRUPTS)		12028103; 1713136; 8422; 27132433; 7549202; 5007901; 17482907	8	0	0		
IP3R1	Channel, calcium; Channel, ligand-gated; Membrane protein, integral; Membrane protein, multi-pass; Receptor, misc.	P11881	16438	Itpr1		mouse	S436	PHOSPHORYLATION	469626	AFAIVPVsPAEVRDL		molecular association, regulation; activity, inhibited				8247; 8937	2	0	0	inhibits binding to IP3 in vitro and IP3R1-mediated intracellular calcium release in vivo; reduces intracellular calcium release in response to anti-IgM stimulation	
PBK	Cancer Testis Antigen (CTA); EC 2.7.12.2; KINASE; Kinase, protein; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor)	Q9JJ78	52033	Pbk		mouse	T9	PHOSPHORYLATION	451735	EGINNFKtPNKSEKR		enzymatic activity, induced				7708	4	2	2	activated in the mitotic cells	
STLK3	EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, STE; Protein kinase, Ser/Thr (non-receptor)	Q9Z1W9	53416	Stk39		mouse	T243	PHOSPHORYLATION	456505	TRNKVRKtFVGTPCW	Pkinase	enzymatic activity, induced				7457; 17630301	9	3	36		
PLM	Cell surface; Channel, misc.; Membrane protein, integral	P56513	476487	FXYD1		dog	S88	PHOSPHORYLATION	451425	RSSIRRLsTRRR___	IncA	activity, induced				4397; 3335909	21	1	74	increases Na(+) affinity of ATP1A1/B1; regulation of cardiac contractility	
AIP	Transcription, coactivator/corepressor	O00170	9049	AIP	11q13.3	human	S53	PHOSPHORYLATION	10888703	EGTVLDDsRARGKPM	FKBP_C	intracellular localization				10167104	1	0	0		
KCNMA1	Channel, potassium; Endoplasmic reticulum; Membrane protein, integral; Membrane protein, multi-pass	Q8AYS8	374065	KCNMA1		chicken	T989	PHOSPHORYLATION	485931	ALRGGYStPQTLANR		intracellular localization				22463944	1	4	3		
Shc1	Adaptor/scaffold; Apoptosis; Mitochondrial; Motility/polarity/chemotaxis	P29353	6464	SHC1	1q21	human	Y349	PHOSPHORYLATION	448509	EEPPDHQyYNDFPGK		molecular association, regulation	apoptosis, altered; apoptosis, inhibited	Grb2(INDUCES)		1274; 7309803; 6149	27	15	922		
SGO1	Cell cycle regulation	Q5FBB7	151648	SGOL1	3p24.3	human	S14	PHOSPHORYLATION	486241	LKKSFQDsLEDIKKR	Atg14		chromatin organization, altered			12089	1	0	0	required for proper association between the kinetochore and spindle microtubules	
caldesmon	Actin binding protein	P12957	373965	CALD1		chicken	S602	PHOSPHORYLATION	457430	CFSPKGSsLKIEERA	Caldesmon	molecular association, regulation		ACTB(NOT_REPORTED)		2852623	2	6	0		
RRAD	G protein; G protein, monomeric, RGK	P55042	6236	RRAD	16q22	human	S290	PHOSPHORYLATION	457397	GRIVARNsRKMAFRA		molecular association, regulation		calmodulin(INDUCES)		7055	1	0	0		
CDX2	DNA binding protein; Transcription factor	Q99626	1045	CDX2	13q12.3	human	S283	PHOSPHORYLATION	456208	RSVPEPLsPVSSLQA		protein degradation				6621	1	1	0		
CDK1	EC 2.7.11.22; EC 2.7.11.23; KINASE; Kinase, protein; Motility/polarity/chemotaxis; Protein kinase, CMGC; Protein kinase, Ser/Thr (non-receptor)	P06493	983	CDK1	10q21.1	human	T161	PHOSPHORYLATION	447609	GIPIRVYtHEVVTLW	Pkinase	molecular association, regulation; enzymatic activity, induced	cell cycle regulation; cell growth, altered	CCNB1(INDUCES); CCNA2(INDUCES)		6173; 627; 631; 8109	20	25	81		
LRRK2	EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, Ser/Thr (non-receptor); Protein kinase, TKL	Q5S007	120892	LRRK2	12q12	human	S935	PHOSPHORYLATION	4725898	NLQRHSNsLGPIFDH		molecular association, regulation; intracellular localization; phosphorylation		14-3-3 beta(INDUCES); 14-3-3 theta(INDUCES); 14-3-3 zeta(INDUCES); 14-3-3 epsilon(INDUCES); 14-3-3 eta(INDUCES)		15022721; 15022728; 21691001	12	9	2	stimulates phosphorylation of S973	
MYPT1	Motility/polarity/chemotaxis; Protein phosphatase, regulatory subunit	Q10728	116670	Ppp1r12a		rat	S854	PHOSPHORYLATION	451999	RPREKRRsTGVSFWT		intracellular localization				3995	7	1	14		
PKCD	EC 2.7.10.2; EC 2.7.11.13; KINASE; Kinase, protein; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor)	Q05655	5580	PRKCD	3p21.31	human	Y52	PHOSPHORYLATION	447574	VQKKPTMyPEWKSTF		activity, inhibited	apoptosis, altered			3522	4	0	0		
moesin	Cytoskeletal protein; Motility/polarity/chemotaxis	P26041	17698	Msn		mouse	T558	PHOSPHORYLATION	447706	LGRDKYKtLRQIRQG	ERM	molecular association, regulation	cell motility, altered; cytoskeletal reorganization	moesin(INDUCES)		12066002; 2385; 670; 7313800	27	3	27	iincreased filopodia with phosphorylated ERM proteins	
Arg	EC 2.7.10.2; KINASE; Kinase, protein; Protein kinase, TK; Protein kinase, tyrosine (non-receptor)	Q4JIM5	11352	Abl2		mouse	Y272	PHOSPHORYLATION	456540	KCNKPTVyGVSPIHD		enzymatic activity, induced				12482266	2	2	3		
Chk2	EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, CAMK; Protein kinase, Ser/Thr (non-receptor)	O96017	11200	CHEK2	22q12.1	human	S19	PHOSPHORYLATION	447546	SHGSSACsQPHGSVT	DUF966	molecular association, regulation; enzymatic activity, induced	cell cycle regulation	Chk2(INDUCES)		12176	11	1	0	S19A mutant shows impaired dimerization and does not promote Hdmx degradation	
DAPK1	Apoptosis; Autophagy; EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, CAMK; Protein kinase, Ser/Thr (non-receptor)	P53355	1612	DAPK1	9q21.33	human	S289	PHOSPHORYLATION	457379	QALSRKAsAVNMEKF		activity, inhibited	apoptosis, altered			6978	1	5	22	Phosphorylation of site suppresses apoptotic activity of DAPK	
HIPK2	EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, CMGC; Protein kinase, Ser/Thr (non-receptor)	Q9H2X6	28996	HIPK2	7q32-q34	human	K552	UBIQUITINATION	3059902	FQNMEICkRRVNMYD		protein degradation				2831762	1	0	0		
THOC4	Chaperone; RNA binding protein; Spliceosome; Transcription, coactivator/corepressor	Q86V81	10189	ALYREF	17q25.3	human	T219	PHOSPHORYLATION	4614100	GGGTRRGtRGGARGR	FoP_duplication	activity, induced	cell growth, altered			4313629	1	1	0	required for THOC4 mRNA export activity	
CD3Z	Membrane protein, integral; Receptor, misc.	P20963	919	CD247	1q24.2	human	Y72	PHOSPHORYLATION	448936	QQGQNQLyNELNLGR	ITAM	phosphorylation				2576201	3	10	380	required for ERK phosphorylation after SDF1a treatment	
Mos	EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor)	P00536	17451	Mos		mouse	S63	PHOSPHORYLATION	466945	RYLPRELsPSVDSRS		protein stabilization; molecular association, regulation	cell growth, altered			10144202	2	1	0		
eIF4E	Translation; Translation initiation	P63073	13684	Eif4e		mouse	T210	PHOSPHORYLATION	450199	TATKSGStTKNRFVV		molecular association, regulation; protein conformation		eIF4G(INDUCES)		2343	3	2	0		
ADORA2A	GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR	P11617	403960	ADORA2A		dog	T298	PHOSPHORYLATION	451126	RIREFRQtFRKIIRS		receptor desensitization, altered				3320	1	0	0	The integrity of T298 is essential for short-term but not long-term desensitization of A2aAR function. 	
CTNNB1	Actin binding protein; Cell adhesion; Motility/polarity/chemotaxis; Nuclear receptor co-regulator; Transcription factor	P35222	1499	CTNNB1	3p21	human	Y86	PHOSPHORYLATION	447584	VADIDGQyAMTRAQR		protein stabilization; molecular association, regulation	transcription, induced; transcription, altered; cell growth, altered	TCF4(INDUCES); TBN(INDUCES); axin 1(DISRUPTS)		17827004; 2701903	5	1	21		
NDEL1	Microtubule binding protein; Protease	Q9ERR1	83431	Ndel1		mouse	S198	PHOSPHORYLATION	474508	TRKSAPSsPTLDCEK	NUDE_C	activity, induced; intracellular localization	cell motility, altered			2425202	3	11	0	Cdc42 activation	
ARHGEF7	Guanine nucleotide exchange factor, Rac/Rho; Motility/polarity/chemotaxis	Q14155	8874	ARHGEF7	13q34	human	Y620	PHOSPHORYLATION	3753309	PAPLTPAyHTLPHPS		activity, induced; molecular association, regulation	cell growth, altered	EGFR(INDUCES); Cdc42 iso1(INDUCES); Cbl-b(INDUCES)		8196	2	0	3	GEF activity for Cdc42	
Rb	Nuclear receptor co-regulator; Transcription, coactivator/corepressor; Tumor suppressor	P06400	5925	RB1	13q14.2	human	S795	PHOSPHORYLATION	447979	SPYKFPSsPLRIPGG	Rb_C	molecular association, regulation; activity, inhibited	cell cycle regulation; cell growth, induced; cell growth, altered	ARF1(DISRUPTS); E2F1(DISRUPTS); TFDP1(DISRUPTS)		6906; 21356304; 777; 6276; 7267; 774; 3412; 4759	34	9	87		
GGA3	Adaptor/scaffold; Vesicle protein	Q9NZ52	23163	GGA3	17q25.1	human	S368	PHOSPHORYLATION	456842	QASGPPRsRSSSQAE		molecular association, regulation; protein conformation				6849	1	0	0	phosphorylation of this residue regulates the association of GGA3 with membranes	
CAMK2A iso2	EC 2.7.11.17; KINASE; Kinase, protein; Protein kinase, CAMK; Protein kinase, Ser/Thr (non-receptor)	Q9UQM7-2	815	CAMK2A	5q32	human	S332	PHOSPHORYLATION	3143902	DGVKKRKsSSSVQLM	Rsd_AlgQ	intracellular localization				10274617	1	1	1	blocks nuclear localization	
DNER	Membrane protein, integral; Receptor, misc.	Q8NFT8	92737	DNER	2q36.3	human	Y677	PHOSPHORYLATION	473321	QGSSRPAyEEFYNCR		intracellular localization				2831768	1	1	4		
PTPRO	EC 3.1.3.48; Membrane protein, integral; Motility/polarity/chemotaxis; PHOSPHATASE; Receptor protein phosphatase, tyrosine	E9Q612	19277	Ptpro		mouse	Y1220	PHOSPHORYLATION	14312604	FCISDVIyENVSKS_		molecular association, regulation	cytoskeletal reorganization	Fyn(INDUCES); Grb2(INDUCES)		14081207	1	0	2		
RBCK1	EC 6.3.2.-; Ligase; UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase	Q62921		Rbck1		rat	T161	PHOSPHORYLATION	2103604	DLGFKDLtLQPRGPL		protein stabilization				1968300	1	0	0	inhibits self-ubiquitination of RBCK1 in vitro	
IkB-alpha	DNA binding protein; Inhibitor protein	P25963	4792	NFKBIA	14q13	human	T291	PHOSPHORYLATION	451526	EDEESYDtESEFTEF		protein degradation				12482204	4	0	0	S283/T291/T299A  triple mutant showed increased IkB-alpha stability.	
LKB1	Autophagy; EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, CAMK; Protein kinase, Ser/Thr (non-receptor)	Q9WTK7	20869	Stk11		mouse	Y261	PHOSPHORYLATION	13258700	PFEGDNIyKLFENIG	Pkinase	intracellular localization; phosphorylation				12775501	2	0	0	mutation of this site increses AMPK phosphorylation	
SCN2A	Channel, sodium; Membrane protein, integral; Membrane protein, multi-pass	P04775	24766	Scn2a		rat	S573	PHOSPHORYLATION	451193	LFSPRRNsRASLFNF	DUF3451	activity, inhibited				8665; 3255; 3928	4	2	1		
IGFBP1	Secreted; Secreted, signal peptide	P08833	3484	IGFBP1	7p13-p12	human	S123	PHOSPHORYLATION	4668105	AEAGSPEsPESTEIT		molecular association, regulation		IGF1(INDUCES)		14081202	3	5	0		
Cx31	Channel, misc.; Membrane protein, integral; Membrane protein, multi-pass	P28231	14620	Gjb3		mouse	S266	PHOSPHORYLATION	2907500	KLQASAPsLTPI___		activity, induced; protein stabilization				8408	1	1	0		
PHOX2A	DNA binding protein; Transcription factor	O14813	401	PHOX2A	11q13.2	human	S202	PHOSPHORYLATION	9400303	PPAPGLAsPRLSPSP		phosphorylation				9158113	1	1	0	regulates phosphorylation of PHOX2A S153	
CKAP4	Endoplasmic reticulum; Membrane protein, integral	Q07065	10970	CKAP4	12q23.3	human	S19	PHOSPHORYLATION	455355	GHGAASPsEKGAHPS			cytoskeletal reorganization			4595	3	1	0	Mutation of S3, S17 and S19 to glutamate leads to a collapse of the endoplasmic reticulum around the nucleus in interphase cells.	
IPMK	Carbohydrate Metabolism - inositol phosphate; EC 2.7.1.151; Kinase, other; Motility/polarity/chemotaxis	Q99NI4	171458	Ipmk		rat	Y174	PHOSPHORYLATION	22826100	YHLHSDSyETQNQHY	IPK	molecular association, regulation		AMPKA2(INDUCES)		22723934	1	0	0		
NRL	DNA binding protein; Transcription factor	P54845	4901	NRL	14q11.1-q11.2	human	S50	PHOSPHORYLATION	478419	PYSSVPPsPTFSEPG		activity, inhibited	transcription, altered			9589	2	0	1		
MKP-1	EC 3.1.3.16; EC 3.1.3.48; Motility/polarity/chemotaxis; PHOSPHATASE; Protein phosphatase, dual-specificity	P28562	1843	DUSP1	5q34	human	S359	PHOSPHORYLATION	448660	SALSYLQsPITTSPS		protein stabilization				901	3	0	0		
PLCG2	Carbohydrate Metabolism - inositol phosphate; EC 3.1.4.11; Motility/polarity/chemotaxis; Phospholipase	P24135	29337	Plcg2		rat	Y753	PHOSPHORYLATION	447940	ERDINSLyDVSRMYV		enzymatic activity, induced				2451	7	11	294		
Chk2	EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, CAMK; Protein kinase, Ser/Thr (non-receptor)	O96017	11200	CHEK2	22q12.1	human	T205	PHOSPHORYLATION	12473001	VFVFFDLtVDDQSVY		enzymatic activity, inhibited	cell cycle regulation			12190200	1	1	0	mutation of this site impairs checkpoint recovery	
TRF1	DNA binding protein	P54274	7013	TERF1	8q21.11	human	S219	PHOSPHORYLATION	448475	SKLLMIIsQKDTFHS	TRF; TRAP-gamma		apoptosis, inhibited			1304	1	0	0		
ChAT iso3	ACETYLTRANSFERASE; Acetyltransferase; EC 2.3.1.6; Lipid Metabolism - glycerophospholipid	P28329-3	1103	CHAT	10q11.2	human	S440	PHOSPHORYLATION	449057	VPTYESAsIRRFQEG	Carn_acyltransf	activity, induced; enzymatic activity, induced				4182; 2193	2	1	0		
AR	DNA binding protein; Nuclear receptor; Transcription factor	P10275	367	AR	Xq12	human	S650	PHOSPHORYLATION	448414	GEASSTTsPTEETTQ		intracellular localization	transcription, altered			1881; 1965401	8	4	0		
Pin1	EC 5.2.1.8; Isomerase; Nuclear receptor co-regulator	Q13526	5300	PIN1	19p13	human	S16	PHOSPHORYLATION	447772	PGWEKRMsRSSGRVY	MBD; WW	protein degradation; molecular association, regulation; ubiquitination; intracellular localization	cell cycle regulation	BORA(DISRUPTS)		28722159; 1399; 25185213	8	1	0		
Bcl-3	Apoptosis; Nuclear receptor co-regulator; Transcription regulation	P20749	602	BCL3	19q13.1-q13.2	human	K34	UBIQUITINATION	3627523	GAALPLRkRPLRAPS		protein degradation	transcription, altered			4319	1	0	0		
CSFR	EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Protein kinase, TK; Protein kinase, tyrosine (receptor)	P07333	1436	CSF1R	5q32	human	Y546	PHOSPHORYLATION	2866400	KYKQKPKyQVRWKII	Bravo_FIGEY	molecular association, regulation				7397643	5	0	0	binds to an unidentfied 55 KD phosphorylated protein in vitro. 	
PDX1	DNA binding protein; Transcription factor	P52946	18609	Pdx1		mouse	S66	PHOSPHORYLATION	458402	QGSPPDIsPYEVPPL		protein degradation				7451	3	0	0		
TTK	Cancer Testis Antigen (CTA); EC 2.7.12.1; KINASE; Kinase, protein; Protein kinase, Other; Protein kinase, dual-specificity	P33981	7272	TTK	6q13-q21	human	S821	PHOSPHORYLATION	467281	GQLVGLNsPNSILKA		intracellular localization				4659600; 13164217	7	12	5	regulates kinetochore localization of TTK	
ezrin	Cytoskeletal protein; Motility/polarity/chemotaxis	P15311	7430	EZR	6q25.3	human	Y191	PHOSPHORYLATION	1783300	KDNAMLEyLKIAQDL	FERM_M	molecular association, regulation; phosphorylation		Src(INDUCES)		7109	1	0	2		
PDE6G	EC 3.1.4.17; EC 3.1.4.35; Nucleotide Metabolism - purine; Phosphodiesterase	P09174	18588	Pde6g		mouse	T22	PHOSPHORYLATION	449334	RVIGGPVtPRKGPPK	PDE6_gamma	enzymatic activity, induced; phosphorylation				9187; 2189	5	1	5	decreases phospho-ERK; regulates rod light response	
LIME1	Adaptor/scaffold; Membrane protein, integral	Q9H400	54923	LIME1	20q13.3	human	Y167	PHOSPHORYLATION	463652	ASPVVAEyARVQKRK		molecular association, regulation		CSK(INDUCES)		12482278	1	1	11		
DNAPK	DNA repair; EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, ATYPICAL; Protein kinase, Ser/Thr (non-receptor)	P78527	5591	PRKDC	8q11	human	T3950	PHOSPHORYLATION	473573	GHAFGSAtQFLPVPE	PI3_PI4_kinase	enzymatic activity, inhibited				9164	1	1	0		
DYN2	EC 3.6.5.5; Hydrolase; Microtubule binding protein; Motility/polarity/chemotaxis; Vesicle protein	P39052	25751	Dnm2		rat	Y597	PHOSPHORYLATION	451200	NTEQRNVyKDLRQIE	PH; KcnmB2_inactiv	molecular association, regulation; intracellular localization	carcinogenesis, induced; cell motility, induced; cell growth, induced; cytoskeletal reorganization	caveolin-1(INDUCES)		22599403; 3407	3	1	2	DYN2 Y597 is required for endocytosis and albumin transport. ; Wild-type showed increased motility and increase of large distal tumors, compared to Y231/597F mutant.	
cortactin	Actin binding protein; Cytoskeletal protein; Motility/polarity/chemotaxis	Q14247	2017	CTTN	11q13	human	Y446	PHOSPHORYLATION	448776	GTEPEPVySMEAADY		molecular association, regulation	apoptosis, inhibited	PTP1B(INDUCES)		2704316	2	25	881	potentiates apoptosis during prolonged hyperosmotic stress	
5-LO	EC 1.13.11.34; Lipid Metabolism - arachidonic acid; Lipid Metabolism - linoleic acid; Nuclear envelope; Oxidoreductase	P09917	240	ALOX5	10q11.2	human	S272	PHOSPHORYLATION	450169	CSLERQLsLEQEVQQ	Lipoxygenase	intracellular localization; enzymatic activity, induced				4616701; 6833; 6331300; 2789	6	0	2		
VDR	DNA binding protein; Nuclear receptor; Transcription factor	P11473	7421	VDR	12q13.11	human	S182	PHOSPHORYLATION	454433	TPSFSGDsSSSCSDH		molecular association, regulation	transcription, inhibited	RXRA(DISRUPTS)		4311	1	0	0		
C/EBP-beta	DNA binding protein; Motility/polarity/chemotaxis; Transcription factor	P21272	24253	Cebpb		rat	S111	PHOSPHORYLATION	13373504	PSDYGYVsLGRAGAK		molecular association, regulation	cell growth, induced; transcription, induced		DNA(INDUCES)	13354731	1	1	1		
KIF23	Microtubule binding protein; Motility/polarity/chemotaxis; Motor protein	E9Q5G3	71819	Kif23		mouse	S805	PHOSPHORYLATION	2902205	IPVRHRRsRSAGSRW		intracellular localization	cell cycle regulation; cytoskeletal reorganization			8646	3	1	0	regulates cytokinesis	
PDGFRB	EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Protein kinase, TK; Protein kinase, tyrosine (receptor)	P09619	5159	PDGFRB	5q33.1	human	Y857	PHOSPHORYLATION	447509	DIMRDSNyISKGSTF	Pkinase_Tyr	phosphorylation; enzymatic activity, induced	cell growth, altered			14772309	12	1	1	Y857 mutation to F mutant enhances phoshorylation of Y771	
vimentin	Cytoskeletal protein; Motility/polarity/chemotaxis	P20152	22352	Vim		mouse	S7	PHOSPHORYLATION	455449	_MSTRSVsSSSYRRM	Filament_head		cytoskeletal reorganization			2057	6	11	1		
PAK1	EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, STE; Protein kinase, Ser/Thr (non-receptor)	Q13153	5058	PAK1	11q13-q14	human	S174	PHOSPHORYLATION	7320951	TPAVPPVsEDEDDDD		molecular association, regulation; enzymatic activity, induced	cell cycle regulation	DYNLL2(INDUCES)		9201020	1	7	6	important for mitotic progression	
PDK1	EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor)	Q9Z2A0	18607	Pdpk1		mouse	S504	PHOSPHORYLATION	5938008	LKGEIPWsQELRPEA		enzymatic activity, inhibited				5930009	1	1	0		
CYP17A1	EC 1.14.99.9; Lipid Metabolism - C21-steroid hormone; Oxidoreductase	P05093	1586	CYP17A1	10q24.3	human	S258	PHOSPHORYLATION	464643	KEKFRSDsITNMLDT	p450	enzymatic activity, inhibited; enzymatic activity, induced				13159402; 7866	2	0	0	in vitro; S258 mutants were impaired in both 17alpha-hydroxylase and C(17-20) lyase activities	
Akt1	EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor)	P31750	11651	Akt1		mouse	S473	O-GlcNAc	4261200	RPHFPQFsYSASGTA	Pkinase_C		apoptosis, altered			4261000	2	0	0		
APC	Motility/polarity/chemotaxis; Tumor suppressor	P25054	324	APC	5q21-q22	human	S1510	PHOSPHORYLATION	999606	SSSLSALsLDEPFIQ	APC_crr	phosphorylation				970021	1	0	0	phosphorylation by CK1 primes for S1501 phosphorylation by GSK3	
Rb-like 2	Transcription, coactivator/corepressor	Q08999	5934	RBL2	16q12.2	human	T642	PHOSPHORYLATION	449727	CIAGSPLtPRRVTEV		molecular association, regulation	cell cycle regulation	E2F4(DISRUPTS)		1200	3	8	31		
VEGFR2	EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Protein kinase, TK; Protein kinase, tyrosine (receptor)	P35968	3791	KDR	4q11-q12	human	Y1054	PHOSPHORYLATION	447899	FGLARDIyKDPDYVR	Pkinase_Tyr	molecular association, regulation; receptor internalization, altered; enzymatic activity, induced		Cbl(INDUCES); PLCG1(INDUCES)		2855903; 2325	12	2	102		
NKX3-1	DNA binding protein; Transcription factor	Q99801	4824	NKX3-1	8p21.2	human	S196	PHOSPHORYLATION	4825100	GDLEKHSsLPALKEE		protein degradation; ubiquitination				4641410	2	0	0		
SYT6	Membrane protein, integral; Vesicle protein	Q5T7P8	148281	SYT6	1p13.2	human	T417	PHOSPHORYLATION	456500	RRLKKKKtTIKKNTL	C2	activity, induced				6712	1	0	0		
myocardin	Cell development/differentiation; Transcription factor	Q8VIM5	214384	Myocd		mouse	S812	PHOSPHORYLATION	10791200	EVLLNSHsPIGKVSD		molecular association, regulation	transcription, inhibited	CBP(DISRUPTS)		10353931	1	0	0		
TIE2	EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Protein kinase, TK; Protein kinase, tyrosine (receptor)	Q02858	21687	Tek		mouse	Y1106	PHOSPHORYLATION	448372	TYVNTTLyEKFTYAG		molecular association, regulation; phosphorylation	cell motility, altered	Dok2(INDUCES)		7805	4	0	1	Mutation of Y1106F reduces tyrosine phosphorylation on Dok-R (Dok2).  Mutation prevents Ang1-MH-induced chemotaxis (cannot rescue the null).	
SLC4A4	Membrane protein, integral; Membrane protein, multi-pass; Transporter	Q9Y6R1	8671	SLC4A4	4q21	human	S1026	PHOSPHORYLATION	469803	KKKKKKGsLDSDNDD	Fmp27_WPPW	activity, induced; molecular association, regulation		CA2(INDUCES)		12660600; 8599	2	5	1	S1026 phosphorylation alters stoichiometry shift, while T49 mediates increase in membrane conductance.	
Kv2.1	Channel, cation; Channel, ligand-gated; Channel, potassium; Membrane protein, integral; Membrane protein, multi-pass	P15387	25736	Kcnb1		rat	S771	PHOSPHORYLATION	473561	QLLYSVDsSPPKSLH		activity, inhibited				9216	1	0	0		
ARHGEF2	Guanine nucleotide exchange factor, Rac/Rho; Motility/polarity/chemotaxis	Q60875	16800	Arhgef2		mouse	T114	PHOSPHORYLATION	12473200	SVSLRSKtTTRERPT		molecular association, regulation; activity, inhibited	cytoskeletal reorganization	DYNLT1(DISRUPTS); 14-3-3 eta(INDUCES)		12300002	1	0	0	14-3-3 and DYNLT1 biind ARHGEF2 in a mutually exclusive manner.	
MEF2A	DNA binding protein; Motility/polarity/chemotaxis; Transcription factor	Q02078	4205	MEF2A	15q26	human	S408	PHOSPHORYLATION	449949	SIKSEPIsPPRDRMT			transcription, induced; transcription, altered			7570; 2212	3	4	0		
Notch 1	Membrane protein, integral; Motility/polarity/chemotaxis; Receptor, misc.; Transcription factor	P46531	4851	NOTCH1	9q34.3	human	S2524	PHOSPHORYLATION	467290	PDQWSSSsPHSNVSD	DUF3454	protein degradation; receptor inactivation, altered				8231	1	0	0	Alanine mutation of 4 serines (S2522/S2523/S2524/S2525) causes increased protein stability.	
FGFR3	EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Protein kinase, TK; Protein kinase, tyrosine (receptor)	P22607	2261	FGFR3	4p16.3	human	Y577	PHOSPHORYLATION	463335	RRPPGLDySFDTCKP	Pkinase_Tyr		cell growth, altered			2465	1	1	8		
TNNI3	Actin binding protein; Motility/polarity/chemotaxis; Motor protein	P19429	7137	TNNI3	19q13.4	human	S44	PHOSPHORYLATION	450691	KKSKISAsRKLQLKT		molecular association, regulation		TNNC1(DISRUPTS)		7362300	18	1	0		
MDM2	EC 6.3.2.-; EC 6.3.2.19; Inhibitor protein; Ligase; UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase	Q00987	4193	MDM2	12q14.3-q15	human	S395	PHOSPHORYLATION	447898	SQESEDYsQPSTSSS		protein degradation				8633; 3394301	5	2	0	dephosphorylation stabilizes Mdm2 and increases its affinity for p53, inducing p53 degredation. ; Phosphorylated S260 and S395 and  S260D and S395D mutant peptides inhibited binding of binding of a specific monoclonal antibody raised to Mdm2. Phosphorylation of Mdm2 regulates p53 degradation. 	
IQGAP1	GTPase activating protein, Ras; Motility/polarity/chemotaxis	P46940	8826	IQGAP1	15q26.1	human	S1441	PHOSPHORYLATION	455635	TPDKMKKsKSVKEDS	RasGAP_C		cytoskeletal reorganization			5505	1	1	1	neurite outgrowth in N1E-115 neurons	
p53	Activator protein; DNA binding protein; Motility/polarity/chemotaxis; Nuclear receptor co-regulator; Transcription factor; Tumor suppressor	P04637	7157	TP53	17p13.1	human	K373	UBIQUITINATION	464659	SSHLKSKkGQSTSRH		protein degradation; intracellular localization	transcription, inhibited			12136; 7920	11	0	0	K370/372/373/381/382/386/R mutant shows 613-fold activation of p53	
ING1 iso2	Tumor suppressor	Q9UK53-2	3621	ING1	13q34	human	S126	PHOSPHORYLATION	484008	LGDTAGNsGKAGADR	Hid1; TATR; Bindin	protein degradation; protein stabilization; molecular association, regulation	cell growth, altered	NQO1(INDUCES)		11976; 2704317	2	0	0		
calponin 1	Actin binding protein; Contractile protein; Motility/polarity/chemotaxis; Myosin binding protein	P26932	396522	CNN1		chicken	T184	PHOSPHORYLATION	469595	QGMTAYGtRRHLYDP	Calponin	molecular association, regulation		ACTA1(DISRUPTS)		8316	1	0	1	f-actin (rabbit skeletal muscle) shown by co-sedimentation	
RIMS1	Adaptor/scaffold; Vesicle protein	Q9JIR4	84556	Rims1		rat	S287	PHOSPHORYLATION	455664	KQASRSRsEPPRERK		molecular association, regulation		14-3-3 beta(INDUCES); 14-3-3 gamma(INDUCES); 14-3-3 eta(INDUCES)		5833	1	0	0		
SLAP-130	Adaptor/scaffold	O35601	23880	Fyb		mouse	Y807	PHOSPHORYLATION	449430	VDNDGEIyDDIADGC		molecular association, regulation		Src(INDUCES)		6639	3	2	88		
P2X2	Channel, cation; Channel, ligand-gated; Membrane protein, integral; Membrane protein, multi-pass	P49653	114115	P2rx2		rat	T18	PHOSPHORYLATION	450951	SAFWDYEtPKVIVVR	P2X_receptor	receptor desensitization, altered				3195	1	0	0		
H2B	DNA binding protein	P10853	319187	Hist1h2bn		mouse	S15	PHOSPHORYLATION	449904	APAPKKGsKKAVTKA		phosphorylation	apoptosis, altered			25763600; 4653	9	0	0		
ITGB4 iso2	Cell adhesion; Membrane protein, integral; Motility/polarity/chemotaxis; Receptor, misc.	P16144-2	3691	ITGB4	17q25	human	Y1494	PHOSPHORYLATION	456323	LQGYSVEyQLLNGGE	fn3	activity, induced; molecular association, regulation	cell motility, altered	SHP-2(INDUCES)		17613013	3	0	1	promote SFK (Fyn) activation and tumor cell invasion	
BRCA1	EC 6.3.2.-; Nuclear receptor co-regulator; Transcription, coactivator/corepressor; Tumor suppressor; UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase	P38398	672	BRCA1	17q21	human	S1423	PHOSPHORYLATION	448036	AVLEQHGsQPSNSYP		molecular association, regulation; phosphorylation	cell cycle regulation	ATM(INDUCES)		6402; 1757; 5337; 5260	11	1	1		
Jun	Transcription factor	P05627	16476	Jun		mouse	T93	PHOSPHORYLATION	450449	GHITTTPtPTQFLCP	Jun	molecular association, regulation		NPM1(INDUCES); p14ARF(INDUCES)		4215301	8	0	0		
ChAT iso3	ACETYLTRANSFERASE; Acetyltransferase; EC 2.3.1.6; Lipid Metabolism - glycerophospholipid	P28329-3	1103	CHAT	10q11.2	human	T255	PHOSPHORYLATION	454038	TVLVKDStNRDSLDM	Carn_acyltransf	enzymatic activity, induced				4182	1	0	0		
C/EBP-beta	DNA binding protein; Motility/polarity/chemotaxis; Transcription factor	P17676	1051	CEBPB	20q13.1	human	S76	PHOSPHORYLATION	456166	HERAIDFsPYLEPLG			transcription, induced			15235225	7	0	1		
eIF4B	Translation; Translation initiation	Q8BGD9	75705	Eif4b		mouse	S422	PHOSPHORYLATION	451290	RERSRTGsESSQTGA			translation, altered			6328013	4	21	455		
DRP1	Apoptosis; EC 3.6.5.5; Endoplasmic reticulum; Hydrolase; Microtubule binding protein; Mitochondrial; Motor protein	O35303	114114	Dnm1l		rat	S656	PHOSPHORYLATION	483971	VPVARKLsAREQRDC		molecular association, regulation; intracellular localization	apoptosis, inhibited; cytoskeletal reorganization	FIS1(INDUCES)		4049512; 12238	8	0	0	change in mitochondrial morphology; regulates mitochondrial morphology during potassium ( K+) stimulation 	
ADRB2	GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR	P18762	11555	Adrb2		mouse	S356	PHOSPHORYLATION	458917	TYGNGYSsNSNGRTD		receptor internalization, altered				1713110	15	0	0		
FOXO1A	DNA binding protein; Nuclear receptor co-regulator; Transcription factor	Q9R1E0	56458	Foxo1		mouse	T24	PHOSPHORYLATION	448560	LPRQRSCtWPLPRPE		intracellular localization	transcription, inhibited			2895; 4904511	46	3	36		
MeCP2	Transcription, coactivator/corepressor	Q00566	29386	Mecp2		rat	S421	PHOSPHORYLATION	470075	EKMPRAGsLESDGCP		activity, induced	cell differentiation, altered; transcription, induced			8970	6	4	0		
BANP	Tumor suppressor	Q8VBU8	53325	Banp		mouse	S347	PHOSPHORYLATION	475059	SFSRRTPsSSSYSAS		intracellular localization				12028116	2	0	0	translocation from nucleus to cytoplasm	
occludin	Cell adhesion; Membrane protein, integral; Membrane protein, multi-pass; Motility/polarity/chemotaxis	Q16625	100506658	OCLN	5q13.1	human	Y398	PHOSPHORYLATION	5393504	KRTEQDHyETDYTTG	DUF342; APG6	molecular association, regulation; intracellular localization		ZO1(INDUCES)		5354427	1	3	1		
FZR1	Ubiquitin conjugating system	Q9UM11	51343	FZR1	19p13.3	human	T121	PHOSPHORYLATION	3827860	DRRLQPStPEKKGLF		activity, inhibited	apoptosis, induced			4641433	1	0	12	inhibits cyclin B1 degradation	
PGK1	Carbohydrate Metabolism - glycolysis and gluconeogenesis; EC 2.7.2.3; Kinase, other	P00558	5230	PGK1	Xq13.3	human	Y76	PHOSPHORYLATION	463986	GVPMPDKySLEPVAV	PGK	molecular association, regulation	cell growth, altered		RNA(DISRUPTS)	10425114	1	2	104	binds to uPAR mRNA and regulates the uPAR expression induced by uPA treatment	
Ron	EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Protein kinase, TK; Protein kinase, tyrosine (receptor)	Q62190	19882	Mst1r		mouse	Y1265	PHOSPHORYLATION	456483	LTRGAPPyPHIDPFD	Pkinase_Tyr	enzymatic activity, induced		Src(NOT_REPORTED)		6720	1	0	0	this site is responsible for constitutive activation of the MAP kinase pathway	
CaMK4	EC 2.7.11.17; KINASE; Kinase, protein; Protein kinase, CAMK; Protein kinase, Ser/Thr (non-receptor)	Q16566	814	CAMK4	5q21.3	human	S12	PHOSPHORYLATION	2135600	TVPSCSAsSCSSVTA			transcription, altered			2758	1	0	2		
CYCS	Apoptosis; Mitochondrial; Oxidoreductase; Protein phosphatase, Ser/Thr (non-receptor)	P62898	25309	Cycs		rat	Y49	PHOSPHORYLATION	473243	GQAAGFSyTDANKNK	Cytochrom_C; UPF0128	molecular association, regulation; activity, inhibited	apoptosis, altered			14790302	3	3	4	Y48E mutation decreases CYCS redox potential; decreases affinity to cardiolipin	
LKB1	Autophagy; EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, CAMK; Protein kinase, Ser/Thr (non-receptor)	Q15831	6794	STK11	19p13.3	human	T363	PHOSPHORYLATION	448151	IEDDIIYtQDFTVPG		enzymatic activity, induced				10296905	4	0	0	STRAD increases LKB1 activation 	
MKLN1	Cell adhesion; Motility/polarity/chemotaxis	O89050	27418	Mkln1		mouse	T515	PHOSPHORYLATION	474505	MVPMTGFtQRATIDP		molecular association, regulation		MKLN1(INDUCES)		9252	1	0	0	mutation inhibited MKLN1 self-association	
cortactin	Actin binding protein; Cytoskeletal protein; Motility/polarity/chemotaxis	Q60598	13043	Cttn		mouse	S417	PHOSPHORYLATION	465632	PIEDRPPsSPIYEDA			cell cycle regulation; cell motility, altered			2790302	1	29	50		
Ets-1	DNA binding protein; Motility/polarity/chemotaxis; Transcription factor	P14921	2113	ETS1	11q23.3	human	T38	PHOSPHORYLATION	447950	CADVPLLtPSSKEMM		activity, induced	transcription, induced; transcription, altered; cell growth, altered			2180; 20834151; 1696; 5894	9	1	5	GSK3B transactivation 	
TTDN1	Cell cycle regulation	Q8TAP9	136647	MPLKIP	7p14.1	human	T120	PHOSPHORYLATION	478367	QGSPRTStPFGSGRV		molecular association, regulation		PLK1(INDUCES)		9605	1	4	13		
SgK269	EC 2.7.10.2; KINASE; Kinase, protein; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor)	Q9H792	79834	PEAK1	15q24.3	human	Y635	PHOSPHORYLATION	449709	IVINPNAyDNLAIYK			cell motility, induced; cell growth, induced; cytoskeletal reorganization	Grb2(INDUCES)		27619317	1	20	1158	enhances cell invasion	
ER-alpha	DNA binding protein; Nuclear receptor	P03372	2099	ESR1	6q25.1	human	S46	PHOSPHORYLATION	12127401	LGEVYLDsSKPAVYN	Oest_recep	activity, induced	transcription, altered			12021304	1	0	0		
P311	Motility/polarity/chemotaxis	Q16612	9315	NREP	5q22.1	human	S59	PHOSPHORYLATION	457551	LGSSELRsPRISYLH	Alveol-reg_P311	protein degradation	cell motility, altered; cell adhesion, altered			7125	1	0	0	P311 S59D and S59E mutants fail to activate Rac1 GTPase	
Kv2.1	Channel, cation; Channel, ligand-gated; Channel, potassium; Membrane protein, integral; Membrane protein, multi-pass	P15387	25736	Kcnb1		rat	Y814	PHOSPHORYLATION	22874700	FLRPNCVySSEGLTG		intracellular localization				22736104	1	1	1	regulates intracellular trafficking of Kv2.1	
NSF	Adaptor/scaffold; Autophagy; EC 3.6.4.6; Protease; Vesicle protein	P46460	18195	Nsf		mouse	S569	PHOSPHORYLATION	460358	FPFIKICsPDKMIGF	AAA	molecular association, regulation	exocytosis, altered	NSF(INDUCES)		7677	1	1	3	inhibits oligomerization, modulates exocytosis	
ANKRD28	Protein phosphatase, regulatory subunit	O15084	23243	ANKRD28	3p25.1	human	S1011	PHOSPHORYLATION	459225	TNTSKTVsFEALPIM		intracellular localization	transcription, inhibited	PPP1CA(DISRUPTS)		9590; 7642	2	10	0		
ATF-4	DNA binding protein; Transcription factor	Q06507	11911	Atf4		mouse	S251	PHOSPHORYLATION	451447	NLPSPGGsRGSPRPK		activity, induced	cell growth, altered			3649	1	0	0		
Smad2	DNA binding protein; Transcription factor	Q15796	4087	SMAD2	18q21.1	human	S245	PHOSPHORYLATION	448794	NQSMDTGsPAELSPT		activity, induced; protein stabilization; molecular association, regulation; intracellular localization; protein conformation	cell motility, altered; transcription, induced	Smad4(INDUCES)		6277008; 3386; 1956	5	0	0	induce vascular invasion	
PLCG1	Carbohydrate Metabolism - inositol phosphate; EC 3.1.4.11; Motility/polarity/chemotaxis; Phospholipase	P08487	281987	PLCG1		cow	Y783	PHOSPHORYLATION	447667	EGRNPGFyVEANPMP		enzymatic activity, induced	transcription, altered			5812	59	25	542	Mutation of Y775 or Y783 reduced PLCG1-mediated calcium mobilization and transcriptional activation	
DNMT1	Amino Acid Metabolism - cysteine and methionine; Cell development/differentiation; EC 2.1.1.37; Methyltransferase; Methyltransferase, DNA; Transcription regulation	P26358	1786	DNMT1	19p13.2	human	S143	PHOSPHORYLATION	3189394	RTPRRSKsDGEAKPE		protein stabilization; methylation				17675034	1	10	6	inhibits K142 methylation	
DARS	EC 6.1.1.12; Ligase; Translation	P14868	1615	DARS	2q21.3	human	S146	PHOSPHORYLATION	18008485	VQKIYVIsLAEPRLP		protein conformation				27928006	0	2	0		
caveolin-2	Adaptor/scaffold; Motility/polarity/chemotaxis	P51636	858	CAV2	7q31.1	human	S135	PHOSPHORYLATION	2765000	SVQTIWKsVTDVIIA	Caveolin; DUF2512	activity, induced				8324	1	0	0	formation of caveolae	
LDH-A	Amino Acid Metabolism - cysteine and methionine; Apoptosis; Carbohydrate Metabolism - glycolysis and gluconeogenesis; Carbohydrate Metabolism - propanoate; Carbohydrate Metabolism - pyruvate; EC 1.1.1.27; Oxidoreductase	P00338	3939	LDHA	11p15.4	human	Y83	PHOSPHORYLATION	3780568	KIVSGKDyNVTANSK	Ldh_1_N	enzymatic activity, induced				21683725	1	1	4		
FOXO1A	DNA binding protein; Nuclear receptor co-regulator; Transcription factor	Q12778	2308	FOXO1	13q14.1	human	S322	PHOSPHORYLATION	449112	PRTSSNAsTISGRLS		intracellular localization				3405; 1093	6	1	0		
HCN2	Channel, cation; Membrane protein, integral; Membrane protein, multi-pass	Q9UL51	610	HCN2	19p13.3	human	T576	PHOSPHORYLATION	15785721	DYIIREGtIGKKMYF	cNMP_binding	activity, inhibited	apoptosis, inhibited			15755120	1	0	0		
DAG1	Cytoskeletal protein; Membrane protein, integral; Motility/polarity/chemotaxis	Q14118	1605	DAG1	3p21	human	Y892	PHOSPHORYLATION	449630	PYRSPPPyVPP____	DAG1	molecular association, regulation; intracellular localization		utrophin(DISRUPTS)		8312; 14790306	5	1	19		
MOB1A	Protein kinase, regulatory subunit; Tumor suppressor	Q9H8S9	55233	MOB1A	2p13.1	human	T74	PHOSPHORYLATION	2506801	QINMLYGtITEFCTE	Mob1_phocein	molecular association, regulation		NDR1(INDUCES); MST2(INDUCES)		2425205	1	0	0	a tripartite complex	
PFKFB2	Carbohydrate Metabolism - fructose and mannose; EC 2.7.1.105; EC 3.1.3.46; Kinase, other; Motility/polarity/chemotaxis; Phosphatase (non-protein)	O60825	5208	PFKFB2	1q31	human	S483	PHOSPHORYLATION	452046	IRRPRNYsVGSRPLK		molecular association, regulation		14-3-3 beta(INDUCES)		8727	6	11	98		
FOXK2	DNA binding protein; Transcription factor	Q01167	3607	FOXK2	17q25	human	S428	PHOSPHORYLATION	3193961	FAQSAPGsPLSSQPV		protein stabilization	apoptosis, altered; transcription, altered			15562511	1	18	5		
Kv4.2	Channel, potassium; Membrane protein, integral; Membrane protein, multi-pass	Q9Z0V2	16508	Kcnd2		mouse	S616	PHOSPHORYLATION	457613	EGDDRPEsPEYSGGN		activity, induced				1172866; 7840	5	0	0		
En-2	DNA binding protein; Transcription factor	P09066	13799	En2		mouse	S267	PHOSPHORYLATION	452011	LTEQRRQsLAQELSL	Homeobox		transcription, altered			3919	1	1	0		
E2F1	DNA binding protein; Transcription factor	Q01094	1869	E2F1	20q11.2	human	S403	PHOSPHORYLATION	447870	PEEFISLsPPHEALD		protein degradation; intracellular localization	cell differentiation, altered; transcription, altered			4641422; 14699300; 1338	5	0	0		
Cdc25C	EC 3.1.3.48; Motility/polarity/chemotaxis; PHOSPHATASE; Protein phosphatase, dual-specificity	P30307	995	CDC25C	5q31	human	S216	PHOSPHORYLATION	448418	SGLYRSPsMPENLNR	M-inducer_phosp	molecular association, regulation; enzymatic activity, inhibited; intracellular localization	cell cycle regulation	14-3-3 beta(INDUCES); 14-3-3 epsilon(INDUCES)		625; 5485; 7418; 7309813; 15331031; 4835202; 2549; 6770; 1173008; 6769; 6576	47	3	41		
PPP1R1A	Inhibitor protein; Protein phosphatase, regulatory subunit	Q13522	5502	PPP1R1A	12q13.2	human	T75	PHOSPHORYLATION	471085	PRQRKKMtRITPTMK	DARPP-32	enzymatic activity, induced	cytoskeletal reorganization			9044	2	0	0	Phosphorylation of PPP1R1A at T75 induces PP1 activity in isolated myocytes and in vitro. Phosphorylation of T75 significantly depresses myocyte contractility, by reducing cardiac contractility by reducing Ca2+ affinity of SERCA2a. 	
HER2	EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Protein kinase, TK; Protein kinase, tyrosine (receptor)	P04626	2064	ERBB2	17q12	human	Y1023	PHOSPHORYLATION	448682	DLVDAEEyLVPQQGF		activity, inhibited	cell adhesion, altered; cell growth, altered			4215300	6	1	25		
PITPNM1	Cell surface	O00562	9600	PITPNM1	11q13	human	S382	PHOSPHORYLATION	451453	DFIDAFAsPVEAEGT		molecular association, regulation		PLK1(INDUCES)		3652	1	1	0		
CCDC6	Apoptosis; Cytoskeletal protein	Q16204	8030	CCDC6	10q21	human	T434	PHOSPHORYLATION	479429	TPPPSPNtQTPVQPP		protein stabilization; molecular association, regulation; intracellular localization	apoptosis, altered	FBXW7(DISRUPTS)		11480; 27132403	3	0	0	nuclear localization	
DAT	Membrane protein, integral; Membrane protein, multi-pass; Transporter	Q01959	6531	SLC6A3	5p15.3	human	S4	PHOSPHORYLATION	454428	____MSKsKCSVGLM		activity, induced				8183	3	0	0	stimulates DAT-mediated efflux of dopamine	
NEUROD1	DNA binding protein; Transcription factor	Q60867	18012	Neurod1		mouse	S259	PHOSPHORYLATION	465678	ALEPFFEsPLTDCTS	Neuro_bHLH		transcription, induced			8116	1	0	0		
tau iso3	Cytoskeletal protein	P10636-3	4137	MAPT	17q21.1	human	S279	PHOSPHORYLATION	449082	PVVSGDTsPRHLSNV		molecular association, regulation	cytoskeletal reorganization			5955602	87	31	69	regulates association with membrane	
DOR-1	GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR	P33533	24613	Oprd1		rat	T161	PHOSPHORYLATION	455533	VKALDFRtPAKAKLI	7tm_1	molecular association, regulation; intracellular localization		MOR-1(INDUCES)		7324307	3	0	0	involved in morphine antinociceptive tolerance	
TRPC6 iso2	Channel, cation; Membrane protein, integral; Membrane protein, multi-pass	Q99N77	89823	Trpc6		rat	S714	PHOSPHORYLATION	455910	VPFNLVPsPKSLLYL		molecular association, regulation		FKBP12(INDUCES); PPP3CA(INDUCES); calmodulin(INDUCES)		6361	1	0	0		
Syk	EC 2.7.10.2; KINASE; Kinase, protein; Protein kinase, TK; Protein kinase, tyrosine (non-receptor)	P43405	6850	SYK	9q22	human	Y526	PHOSPHORYLATION	447662	LRADENYyKAQTHGK	Pkinase_Tyr	enzymatic activity, induced		ITGAM(INDUCES)		6782010; 759; 6482	18	4	70	ITAM peptide binding increases autophosphorylation of Syk.	
IKKB	EC 2.7.11.10; KINASE; Kinase, protein; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor)	O88351	16150	Ikbkb		mouse	S177	PHOSPHORYLATION	447492	AKELDQGsLCTSFVG	Pkinase	enzymatic activity, induced	cell differentiation, induced			22881913	25	0	0	osteoclast differentiation	
PKCB	EC 2.7.11.13; KINASE; Kinase, protein; Motility/polarity/chemotaxis; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor)	P04410	25023	Prkcb		rat	S661	PHOSPHORYLATION	448672	QNEFAGFsYTNPEFV	Pkinase_C	protein conformation				25785427	14	21	140		
Kit	EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Protein kinase, TK; Protein kinase, tyrosine (receptor)	P10721	3815	KIT	4q11-q12	human	S746	PHOSPHORYLATION	450036	RRSVRIGsYIERDVT	Pkinase_Tyr	enzymatic activity, inhibited; phosphorylation				2598	2	4	0		
BDP1	EC 3.1.3.48; Motility/polarity/chemotaxis; Protein phosphatase, tyrosine (non-receptor)	Q99952	26469	PTPN18	2q21.1	human	Y303	PHOSPHORYLATION	450260	LQNASPHyQNIKENC		molecular association, regulation		TEC(INDUCES)		2955	1	0	0		
STAP2	Adaptor/scaffold	Q9UGK3	55620	STAP2	19p13.3	human	Y22	PHOSPHORYLATION	11500606	GVLPSHYyESFLEKK			transcription, altered			10294000	1	0	0		
TAO3	EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, STE; Protein kinase, Ser/Thr (non-receptor)	Q9H2K8	51347	TAOK3	12q	human	S324	PHOSPHORYLATION	468901	RNGPLNEsQEDEEDS		activity, induced	cell cycle regulation			12287	1	27	12		
GAPDH	Carbohydrate Metabolism - glycolysis and gluconeogenesis; EC 1.2.1.12; EC 2.6.99.-; Oxidoreductase	P04406	2597	GAPDH	12p13	human	T237	PHOSPHORYLATION	4658322	GMAFRVPtANVSVVD	Gp_dh_C	intracellular localization	apoptosis, inhibited			21683724	1	1	26	increases cell survival	
CDK16	EC 2.7.11.22; KINASE; Kinase, protein; Motility/polarity/chemotaxis; Protein kinase, CMGC; Protein kinase, Ser/Thr (non-receptor)	Q00536	5127	CDK16	Xp11	human	S153	PHOSPHORYLATION	453451	SRRLRRVsLSEIGFG		molecular association, regulation; intracellular localization; enzymatic activity, inhibited	cytoskeletal reorganization	CBCP1(DISRUPTS)		22723904; 3862	2	29	130		
afadin	Cell adhesion; Motility/polarity/chemotaxis	P55196	4301	MLLT4	6q27	human	T909	PHOSPHORYLATION	6208300	VVTVAENtADELARS		molecular association, regulation		HRas(INDUCES)		6121900	1	0	0	phosphorylation by Bcr induces formation of a complex with Ras	
MKLN1	Cell adhesion; Motility/polarity/chemotaxis	O89050	27418	Mkln1		mouse	S324	PHOSPHORYLATION	474504	TEKENGPsARSCHKM	Kelch_3	molecular association, regulation		MKLN1(INDUCES)		9252	1	0	0	mutation inhibited MKLN1 self-association	
Dok2	Adaptor/scaffold	O70469	13449	Dok2		mouse	Y304	PHOSPHORYLATION	448880	PGAPEGEyAVPFDTV		molecular association, regulation	cell differentiation, altered; cell growth, altered	RASA1(INDUCES)		5379; 7309801; 4091	3	16	767		
NKCC2	Membrane protein, integral; Membrane protein, multi-pass; Transporter	P55016	25065	Slc12a1		rat	T96	PHOSPHORYLATION	458227	TNTYYLQtFGHNTMD	AA_permease_N	activity, induced; intracellular localization				7308; 2831757	8	2	0	observed in triple mutant T96/111/101A	
GH receptor	Membrane protein, integral; Receptor, cytokine	NP_999419	397488	GHR		pig	Y627	PHOSPHORYLATION	486258	EFLSSCGyVSTDQLN			transcription, induced		DNA(INDUCES)	10144217	3	0	0		
PRAS40	Apoptosis	Q9D1F4	67605	Akt1s1		mouse	T247	PHOSPHORYLATION	470067	LPRPRLNtSDFQKLK		phosphorylation				13852011	24	31	739	required for phosphorylation of PRAS40 S184	
Kv2.1	Channel, cation; Channel, ligand-gated; Channel, potassium; Membrane protein, integral; Membrane protein, multi-pass	Q14721	3745	KCNB1	20q13.2	human	Y128	PHOSPHORYLATION	449085	YWGIDEIyLESCCQA	K_tetra	activity, induced	apoptosis, altered			9721217	5	0	0		
IRS1	Adaptor/scaffold; Motility/polarity/chemotaxis	P35570	25467	Irs1		rat	S570	PHOSPHORYLATION	451681	RLPGYRHsAFVPTHS		molecular association, regulation		PIK3R1(DISRUPTS)		6050	4	3	0		
Gab2	Adaptor/scaffold	Q9UQC2	9846	GAB2	11q14.1	human	Y643	PHOSPHORYLATION	450913	TSDEKVDyVQVDKEK		molecular association, regulation; phosphorylation	cell cycle regulation; transcription, altered	SHP-2(INDUCES)		3905; 3309500	4	5	172	activates Erk1/2 and regulates cells proliferation;  ; Binding of SHP-2 activates the MAPK pathway and transcription.; in the presence of GCSFR	
ATM	EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, ATYPICAL; Protein kinase, Ser/Thr (non-receptor)	Q13315	472	ATM	11q22-q23	human	K3016	ACETYLATION	1968604	VLMRLQEkLKGVEEG		enzymatic activity, induced				1908940	1	0	0		
PTPRE iso2	EC 3.1.3.48; Membrane protein, integral; Motility/polarity/chemotaxis; PHOSPHATASE; Protein phosphatase, tyrosine (non-receptor); Receptor protein phosphatase, tyrosine	P49446-2	19267	Ptpre		mouse	Y638	PHOSPHORYLATION	450705	FIDIFSDyANFK___		molecular association, regulation	cell adhesion, altered	Pyk2(INDUCES); Src(INDUCES)		9980404	4	12	558		
PITPNB	Lipid binding protein	P53811	56305	Pitpnb		mouse	S262	PHOSPHORYLATION	451299	ETMRKKGsVRGTSAA		activity, induced; intracellular localization	apoptosis, induced; cell growth, altered			1172803; 8732; 3520	5	5	22		
Ikaros	C2H2-type zinc finger protein; DNA binding protein; Transcription factor	Q03267	22778	Ikzf1		mouse	S63	PHOSPHORYLATION	451348	NVKVETQsDEENGRA		activity, inhibited	cell cycle regulation		DNA(DISRUPTS)	3559	2	7	6		
Cbl-b	Adaptor/scaffold; Calcium-binding protein; EC 6.3.2.-; Ligase; UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase	Q13191	868	CBLB	3q13.11	human	Y709	PHOSPHORYLATION	475085	VEEDDDEyKIPSSHP		molecular association, regulation		CrkL(INDUCES)		12482227	2	3	110	in vitro and vivo;  Y709 is major binding site, and to lesser extent Y665	
Kv11.1	Channel, potassium; Membrane protein, integral; Membrane protein, multi-pass; Motility/polarity/chemotaxis	Q12809	3757	KCNH2	7q36.1	human	Y611	PHOSPHORYLATION	3496803	GPSIKDKyVTALYFT	Ion_trans	activity, induced				3309532	1	1	0		
Mpl	Membrane protein, integral; Receptor, cytokine	Q08351	17480	Mpl		mouse	S543	PHOSPHORYLATION	3091407	DTAALSPsKATVTDS		activity, induced; phosphorylation	cell growth, altered			8388	1	0	0	tyrosine phosphorylation of JAK2	
FAM125A	Adaptor/scaffold	Q96EY5	93343	FAM125A	19p13.11	human	S163	PHOSPHORYLATION	3950650	VPKPRGLsRDMQGLS	DUF2464	protein processing				12660601	1	4	7	inhibition of HIV-1 release and infectivity	
p53	Activator protein; DNA binding protein; Motility/polarity/chemotaxis; Nuclear receptor co-regulator; Transcription factor; Tumor suppressor	P04637	7157	TP53	17p13.1	human	K386	SUMOYLATION	2255102	RHKKLMFkTEGPDSD		activity, induced	apoptosis, induced; transcription, altered			2429105; 5085400; 3141449	10	0	0		
FOXM1	DNA binding protein; Transcription factor	Q08050	2305	FOXM1	12p13	human	S704	PHOSPHORYLATION	449265	IDVPKPGsPEPQVSG		protein stabilization	transcription, induced			22495316	1	3	0		
IRS1	Adaptor/scaffold; Motility/polarity/chemotaxis	P35570	25467	Irs1		rat	S357	PHOSPHORYLATION	4859802	HAHRHRGsSRLHPPL		molecular association, regulation; phosphorylation		PKCD(INDUCES)		4214820	2	0	0	leads to reduced phosphorylation of Akt	
REPS2	Adaptor/scaffold; G protein regulator, misc.	Q8NFH8	9185	REPS2	Xp22.2	human	S463	PHOSPHORYLATION	480114	RPRSRSYsSTSIEEA		molecular association, regulation		AP2A1(DISRUPTS)		8751	1	1	4	Phosphorylation inhibits  during mitosis	
PKD2	EC 2.7.11.13; KINASE; Kinase, protein; Motility/polarity/chemotaxis; Protein kinase, CAMK; Protein kinase, Ser/Thr (non-receptor)	Q9BZL6	25865	PRKD2	19q13.3	human	S706	PHOSPHORYLATION	449864	ARIIGEKsFRRSVVG	Pkinase	enzymatic activity, induced				1963	4	6	16		
NEUROD1	DNA binding protein; Transcription factor	Q60867	18012	Neurod1		mouse	S266	PHOSPHORYLATION	465679	SPLTDCTsPSFDGPL	Neuro_bHLH		transcription, induced			8116	1	0	0		
myelin P0	Adaptor/scaffold; Membrane protein, integral	P25189	4359	MPZ	1q23.3	human	Y220	PHOSPHORYLATION	450106	GRQTPVLyAMLDHSR	Protocadherin; Myelin-PO_C	molecular association, regulation				8658	3	0	1	promotes association with 42, 68, and 85 kDa tyrosine phosphorylated proteins	
AR	DNA binding protein; Nuclear receptor; Transcription factor	P10275	367	AR	Xq12	human	S291	PHOSPHORYLATION	15605001	PLAECKGsLLDDSAG	Androgen_recep	activity, induced; molecular association, regulation	transcription, altered; cell growth, altered		DNA(NOT_REPORTED)	15562508	1	0	0		
RCAN1	Inhibitor protein	P53805	1827	RCAN1	21q22.12	human	S167	PHOSPHORYLATION	456023	FLISPPAsPPVGWKQ	Calcipressin	activity, induced; protein degradation	transcription, altered			2413100; 6678	6	18	6	increases calcineurin-inhibiting activity of DSCR1; Phosphorylation of MCIP at S108/S112 by MEKK3 is required for activation of calcineurin/NFAT signaling. 	
APP iso4	Apoptosis; Cell surface; Membrane protein, integral; Receptor, misc.; Transcription factor	P05067-4	351	APP	21q21.3	human	S198	PHOSPHORYLATION	450331	EESDNVDsADAEEDD	SDA1	intracellular localization				3094	1	1	0	APP was phosphorylated within the post Golgi as well as on the cell surface. 	
Met	EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Protein kinase, TK; Protein kinase, tyrosine (receptor)	P08581	4233	MET	7q31	human	Y1003	PHOSPHORYLATION	448469	VSNESVDyRATFPED		activity, induced; protein degradation; protein stabilization; molecular association, regulation; ubiquitination; receptor desensitization, altered; enzymatic activity, induced	cell growth, altered	Cbl(INDUCES); PTP1B(INDUCES); PTPN2(INDUCES)		6115921; 1168; 8165401	9	15	316		
Irx2	DNA binding protein; Transcription factor	Q9PU52	373975	IRX2		chicken	S46	PHOSPHORYLATION	452191	SSSGSAFsPYPGSAA	TFIIA		transcription, altered			4104	1	0	0		
ADRA2A	GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR	P08913	150	ADRA2A	10q25.2	human	S360	PHOSPHORYLATION	467300	RVGAAKAsRWRGRQN	7tm_1; T2SM	receptor desensitization, altered				8217	1	0	0		
PDK1	EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor)	O15530	5170	PDPK1	16p13.3	human	Y373	PHOSPHORYLATION	447694	SEDDEDCyGNYDNLL		enzymatic activity, induced	apoptosis, altered			15658705; 748; 12725501	9	1	0		
OLIG2	Transcription factor	Q9EQW6	50913	Olig2		mouse	S147	PHOSPHORYLATION	18357904	GPSVRKLsKIATLLL	SR-25; HLH	molecular association, regulation	cell differentiation, altered	neurogenin 2(DISRUPTS); OLIG2(INDUCES)		18357500	1	0	0	required for neuroepithelial stem cell differentiation into motor neurons, but not for genesis of oligodendrocyte precursors	
BCAP	Adaptor/scaffold	Q9EQ32	83490	Pik3ap1		mouse	Y460	PHOSPHORYLATION	449909	PAATEDLyVEMLQAS		molecular association, regulation	cell differentiation, altered	PIK3R1(INDUCES)		12482418	2	0	0	regulate Akt activation and B-cell differentiation through binding to PI3KR1	
Cdc25B	EC 3.1.3.48; Motility/polarity/chemotaxis; Nuclear receptor co-regulator; PHOSPHATASE; Protein phosphatase, dual-specificity	P30305	994	CDC25B	20p13	human	S230	PHOSPHORYLATION	470115	AFAQRPSsAPDLMCL	M-inducer_phosp	protein degradation; enzymatic activity, inhibited				28722153; 8999	5	1	0	protects against proteosome degradation of centrosomal centrin; inhibits mitosis-inducing activity of CDC25B	
ARRB2	Adaptor/scaffold	Q91YI4	216869	Arrb2		mouse	T383	PHOSPHORYLATION	455373	EFDTNYAtDDDIVFE		molecular association, regulation; receptor internalization, altered		CLTC(DISRUPTS)		8346	3	0	2	decreases beta2-adrenergic receptor internalization	
HPK1	EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, STE; Protein kinase, Ser/Thr (non-receptor)	Q92918	11184	MAP4K1	19q13.1-q13.4	human	S171	PHOSPHORYLATION	455474	ATLARRLsFIGTPYW	Pkinase	enzymatic activity, induced	transcription, altered			5232	3	1	7		
Bcl-xL	Apoptosis; Autophagy; Membrane protein, integral; Mitochondrial	P53563	24888	Bcl2l1		rat	S228	PHOSPHORYLATION	5014912	AGVVLLGsLFSRK__			apoptosis, altered			5014014	1	0	0		
p53	Activator protein; DNA binding protein; Motility/polarity/chemotaxis; Nuclear receptor co-regulator; Transcription factor; Tumor suppressor	P04637	7157	TP53	17p13.1	human	T81	PHOSPHORYLATION	447540	APAPAAPtPAAPAPA	DEC-1_N	molecular association, regulation; protein stabilization	apoptosis, induced; transcription, induced; transcription, altered	Pin1(INDUCES)		6045; 1214; 6046	8	1	1		
SPAG5	Cell cycle regulation	Q96R06	10615	SPAG5	17q11.2	human	T111	PHOSPHORYLATION	460413	PIPQISStPKTSEEA		intracellular localization				1172873	1	3	4	required for SPAG5 localization to the spindle apparatus during mitosis	
SgK307	Cancer Testis Antigen (CTA); KINASE; Kinase, protein; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor)	Q8IWB6	56155	TEX14	17q22	human	S437	PHOSPHORYLATION	25158900	QKAATVKsDIYSFSM	Pkinase_Tyr	protein degradation; intracellular localization	cell cycle regulation			25082834	1	0	0		
PXN	Adaptor/scaffold; Cell adhesion; Cytoskeletal protein; Motility/polarity/chemotaxis	P49023	5829	PXN	12q24.31	human	S126	PHOSPHORYLATION	450227	SFPNKQKsAEPSPTV	Paxillin		cell motility, induced; cytoskeletal reorganization			27902332	6	14	4	HGF mediated  disassembly of focal adhesions and cell migration 	
REL	Transcription factor	Q04864	5966	REL	2p13-p12	human	S557	PHOSPHORYLATION	480318	SNTTVFVsQSDAFEG			transcription, altered			11747	1	0	0		
Abi-1	Adaptor/scaffold; Motility/polarity/chemotaxis	Q8IZP0	10006	ABI1	10p11.2	human	S267	PHOSPHORYLATION	18715503	PIAVPTPsPPTIGPE		molecular association, regulation	cell motility, altered; cytoskeletal reorganization			18668222	1	0	1	regulates WRC (WAVE2 regulatory complex) interaction with Arp2/3 and lamellipodial protrusion	
WAVE1	Cytoskeletal protein; Motility/polarity/chemotaxis	Q8R5H6	83767	Wasf1		mouse	S441	PHOSPHORYLATION	7979602	PPGIRPSsPVAVAAL		activity, inhibited				14081210	3	0	0		
PIK3C3	Autophagy; Carbohydrate Metabolism - inositol phosphate; EC 2.7.1.137; Kinase, lipid; Motility/polarity/chemotaxis	Q8NEB9	5289	PIK3C3	18q12.3	human	T159	PHOSPHORYLATION	14659500	DGSEPTKtPGRTSST	PI3K_C2; tRNA_bind_2	molecular association, regulation; enzymatic activity, inhibited	endocytosis, altered	beclin 1(DISRUPTS)		14551424	1	0	0	inhibits autophagy	
MITF iso8	DNA binding protein; Transcription factor	Q08874-8	17342	Mitf		mouse	S409	PHOSPHORYLATION	450265	KTSSRRSsMSAEETE	DUF3371	molecular association, regulation	transcription, induced	PIAS3(DISRUPTS)		8644	8	1	0		
PXN	Adaptor/scaffold; Cell adhesion; Cytoskeletal protein; Motility/polarity/chemotaxis	Q66H76	360820	Pxn		rat	Y118	PHOSPHORYLATION	448604	AGEEEHVySFPNKQK	Paxillin	activity, induced; molecular association, regulation; intracellular localization	cell motility, altered	DOCK1(INDUCES); Crk(INDUCES)		19016901; 4744	55	48	2522	activation of Rac1; colocalized in glucose induced filipodia extensions, leading to insulin secretion	
Rb	Nuclear receptor co-regulator; Transcription, coactivator/corepressor; Tumor suppressor	P13405	19645	Rb1		mouse	S601	PHOSPHORYLATION	447976	TAADMYLsPLRSPKK		molecular association, regulation		E2F1(DISRUPTS)		1258	7	6	30		
DAT	Membrane protein, integral; Membrane protein, multi-pass; Transporter	Q01959	6531	SLC6A3	5p15.3	human	S12	PHOSPHORYLATION	451137	KCSVGLMsSVVAPAK		activity, induced				3338; 8183	5	0	0	stimulates DAT-mediated efflux of dopamine	
hnRNP K iso2	RNA binding protein; RNA splicing; Spliceosome	P61979-2	15387	Hnrnpk		mouse	S116	PHOSPHORYLATION	452369	EEGLQLPsPTATSQL		intracellular localization				17482905	2	19	14		
CD300LB	Membrane protein, integral; Receptor, misc.	A8K4G0	124599	CD300LB	17q25.1	human	Y188	PHOSPHORYLATION	975498	EPGEQPIyMNFSEPL		activity, induced	transcription, altered	Grb2(INDUCES)		970038; 12482275	2	1	0	cytokine production; Interaction with Grb2 required Fyn. 	
lamin A/C	Cytoskeletal protein	P02545	4000	LMNA	1q22	human	S22	PHOSPHORYLATION	452604	QASSTPLsPTRITRL	IncA; Myosin_tail_1	activity, induced; intracellular localization	cell cycle regulation; cytoskeletal reorganization			4641430; 7124720; 7523	6	52	119		
NME3	Apoptosis; EC 2.7.4.6; Kinase, nucleoside diphosphate; Kinase, other; Motility/polarity/chemotaxis; Nucleotide Metabolism - purine; Nucleotide Metabolism - pyrimidine	Q13232	4832	NME3	16q13.3	human	S61	PHOSPHORYLATION	3137800	ALKLVQAsEELLREH	NDK	molecular association, regulation	cell differentiation, altered	NME1(INDUCES)		8426	1	0	0		
AML1 iso8	DNA binding protein; Transcription factor	Q01196-8	861	RUNX1	21q22.3	human	S303	PHOSPHORYLATION	454401	VHPATPIsPGRASGM		protein degradation; molecular association, regulation; phosphorylation	cell growth, altered	HDAC1(DISRUPTS); HDAC3(DISRUPTS)		17431513; 9029; 6620	11	5	64	increases marrow progenitor proliferation	
BCAP	Adaptor/scaffold	Q9DDT2	374268	PIK3AP1		chicken	Y423	PHOSPHORYLATION	450044	GEEDESVyESMAHLS		molecular association, regulation		PIK3R1(INDUCES)		1374	2	0	9		
ASIC1	Channel, cation; Membrane protein, integral; Membrane protein, multi-pass	P78348	41	ASIC1	12q12	human	S40	PHOSPHORYLATION	6057800	IFSYERLsLKRALWA	ASC	activity, inhibited				5930035	1	0	0		
FLNA	Actin binding protein; Motility/polarity/chemotaxis; Nuclear receptor co-regulator	Q8BTM8	192176	Flna		mouse	S2152	PHOSPHORYLATION	451357	TRRRRAPsVANIGSH			cytoskeletal reorganization			26349402	10	40	934		
LRRK2	EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, Ser/Thr (non-receptor); Protein kinase, TKL	Q5S007	120892	LRRK2	12q12	human	T1410	PHOSPHORYLATION	10426324	STHPHFMtQRALYLA	Miro	molecular association, regulation; enzymatic activity, induced		LRRK2(INDUCES)		15755107	3	4	0	T1410A mutation has a small effect on protein's dimerization, it reduces GTPase activity of LRRK2	
GRF-1	GTPase activating protein, Rac/Rho; Motility/polarity/chemotaxis; Transcription factor	Q9NRY4	2909	ARHGAP35	19q13.3	human	S1221	PHOSPHORYLATION	10406116	RRRNILRsLRRNTKK		molecular association, regulation	cytoskeletal reorganization			10425112	1	0	1	prevents the association of the protein with acidic phospholipids and modulate the GTPase substrate preference	
Mpl	Membrane protein, integral; Receptor, cytokine	P40238	4352	MPL	1p34	human	K553	UBIQUITINATION	11956704	TAALSPPkATVSDTC		protein degradation	cell growth, inhibited			11387288	1	0	0		
STLK3	EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, STE; Protein kinase, Ser/Thr (non-receptor)	Q9UEW8	27347	STK39	2q24.3	human	S309	PHOSPHORYLATION	450930	MMKKYGKsFRKLLSL	Pkinase	enzymatic activity, induced				3187	1	0	0		
TGFBR2	EC 2.7.11.30; KINASE; Kinase, protein; Membrane protein, integral; Protein kinase, Ser/Thr (receptor); Protein kinase, TKL	P37173	7048	TGFBR2	3p22	human	S416	PHOSPHORYLATION	452049	SVDDLANsGQVGTAR	Pkinase	enzymatic activity, inhibited				3992	1	0	0		
NCAM-L1	Cell adhesion; Membrane protein, integral	P32004	3897	L1CAM	Xq28	human	Y1151	PHOSPHORYLATION	466002	KRSKGGKySVKDKED	Bravo_FIGEY	protein conformation; phosphorylation				9985921	2	0	0	mutation of this site promotes phosphorylation of N-CAML1  Y1176, Y1211, Y1229 and T1172	
NFAT1	DNA binding protein; Transcription factor	Q60591	18019	Nfatc2		mouse	S215	PHOSPHORYLATION	447845	QNIPAHYsPRTSPIM			transcription, inhibited			1188	1	1	4		
Src	EC 2.7.10.2; KINASE; Kinase, protein; Protein kinase, TK; Protein kinase, tyrosine (non-receptor)	P05480	20779	Src		mouse	Y221	PHOSPHORYLATION	448233	KLDSGGFyITSRTQF	SH2	molecular association, regulation		Grb2(INDUCES)		6475	7	2	21		
CREB	DNA binding protein; Transcription factor	P16220	1385	CREB1	2q34	human	S117	PHOSPHORYLATION	451810	DSQESVDsVTDSQKR	pKID	phosphorylation				9565	4	0	0	mutation to alanine decreases S121 phosphorylation in cells treated with ionizing radiation 	
PELP1	Nuclear receptor co-regulator; Transcription, coactivator/corepressor	Q8IZL8	27043	PELP1	17p13.2	human	S477	PHOSPHORYLATION	470174	ADALKLRsPRGSPDG	NUC202		cell cycle regulation; carcinogenesis, altered; transcription, altered			15278800	1	9	17		
PXN	Adaptor/scaffold; Cell adhesion; Cytoskeletal protein; Motility/polarity/chemotaxis	P49023	5829	PXN	12q24.31	human	S85	PHOSPHORYLATION	451054	HQQPQSSsPVYGSSA	Paxillin		cell adhesion, altered			3267	1	22	600		
p53	Activator protein; DNA binding protein; Motility/polarity/chemotaxis; Nuclear receptor co-regulator; Transcription factor; Tumor suppressor	P04637	7157	TP53	17p13.1	human	S366	PHOSPHORYLATION	455223	PGGSRAHsSHLKSKK		activity, induced; molecular association, regulation	transcription, altered	14-3-3 epsilon(INDUCES); 14-3-3 gamma(INDUCES)		4400; 12300001; 4641429	4	0	0		
calponin 1	Actin binding protein; Contractile protein; Motility/polarity/chemotaxis; Myosin binding protein	P26932	396522	CNN1		chicken	T170	PHOSPHORYLATION	469593	IIGLQMGtNKFASQQ	Calponin	molecular association, regulation		ACTA1(DISRUPTS)		8316	2	0	0	f-actin (rabbit skeletal muscle) shown by co-sedimentation	
Cx43	Channel, misc.; Membrane protein, integral; Membrane protein, multi-pass; Motility/polarity/chemotaxis	P23242	14609	Gja1		mouse	S328	PHOSPHORYLATION	449993	GQAGSTIsNSHAQPF		intracellular localization				8241	7	9	0	ischemia induces connexin43 dephosphorylation and its relocalization in the cell and as a result downregulates intracellular communication	
RAF1	EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, Ser/Thr (non-receptor); Protein kinase, TKL	P04049	5894	RAF1	3p25	human	T491	PHOSPHORYLATION	447748	IGDFGLAtVKSRWSG	Pkinase_Tyr	enzymatic activity, induced				6052; 5121526; 1253	5	0	0		
ATP1A1	EC 3.6.3.9; Hydrolase; Membrane protein, integral; Membrane protein, multi-pass	P06685	24211	Atp1a1		rat	S23	PHOSPHORYLATION	449087	SEHGDKKsKKAKKER		receptor internalization, induced; molecular association, regulation; intracellular localization; protein conformation; enzymatic activity, induced		14-3-3 beta(INDUCES)		4023; 1850100; 4581; 2200; 2118; 8669; 5329; 8664; 2626209	18	1	0		
LPP	Adaptor/scaffold; Cytoskeletal protein; Motility/polarity/chemotaxis	Q8BFW7	210126	Lpp		mouse	Y245	PHOSPHORYLATION	449712	GPSSGQIyGPGPRGY			cell cycle regulation; cell motility, altered			2790302	1	8	114		
CIN85	Adaptor/scaffold; Apoptosis; Motility/polarity/chemotaxis	Q96B97	30011	SH3KBP1	Xp22.1-p21.3	human	S587	PHOSPHORYLATION	457025	TAGHRANsPSLFGTE	Tmemb_cc2	molecular association, regulation		DAB1(DISRUPTS)		27258213	1	22	6		
CBX1	Transcription factor	P83916	10951	CBX1	17q21.32	human	T51	PHOSPHORYLATION	2753801	GFSDEDNtWEPEENL	Chromo	molecular association, regulation; intracellular localization		H3(DISRUPTS)	DNA(DISRUPTS)	2704334; 10353913	2	0	0		
TRPV1	Channel, cation; Membrane protein, integral; Membrane protein, multi-pass; Receptor, misc.	Q8NER1	7442	TRPV1	17p13.2	human	S801	PHOSPHORYLATION	450017	VPLLREAsARDRQSA		receptor desensitization, altered				4049522	14	0	0		
tau	Cytoskeletal protein	P19332	29477	Mapt		rat	T542	PHOSPHORYLATION	449079	KKVAVVRtPPKSPSA			cytoskeletal reorganization			4214826	74	20	10		
CITED1	Nuclear receptor co-regulator	P97769	12705	Cited1		mouse	S80	PHOSPHORYLATION	27937108	SPTATPSsKPPSFNL	CITED	intracellular localization	cell differentiation, induced			27780046	1	0	0	S63/64/65/67/69/73/79/80/84A mutation in CITED1 inhibits its translocation into the nucleus and osteoblasts differentiation	
CACNB2 iso2	Channel, calcium	Q08289-2	783	CACNB2	10p12	human	T499	PHOSPHORYLATION	470081	RGLSRQEtFDSETQE		activity, induced	apoptosis, induced			12670100	5	3	17		
PXN	Adaptor/scaffold; Cell adhesion; Cytoskeletal protein; Motility/polarity/chemotaxis	P49024	395832	PXN		chicken	S273	PHOSPHORYLATION	465466	ELDELMAsLSDFKFM	EAP30	molecular association, regulation		FAK(DISRUPTS)		1713147	7	6	0	interaction in vitro	
RAF1	EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, Ser/Thr (non-receptor); Protein kinase, TKL	P04049	5894	RAF1	3p25	human	S289	PHOSPHORYLATION	455311	RSHSESAsPSALSSS		molecular association, regulation; intracellular localization; enzymatic activity, inhibited; enzymatic activity, induced		HRas(DISRUPTS)		4487; 1962902	3	8	47	phosphorylation of S289, S296, and S301 sustains and increases kinase activity	
CITED1	Nuclear receptor co-regulator	P97769	12705	Cited1		mouse	S67	PHOSPHORYLATION	27937110	VPTSSSGsTSPIGSP	CITED	intracellular localization	cell differentiation, induced			27780046	1	0	0	S63/64/65/67/69/73/79/80/84A mutation in CITED1 inhibits its translocation into the nucleus and osteoblasts differentiation	
Myt1	EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, Other; Protein kinase, dual-specificity	Q99640	9088	PKMYT1	16p13.3	human	S441	PHOSPHORYLATION	11331000	DSLGPSLsPEAVLAR		molecular association, regulation		Pin1(INDUCES)		7981800	1	0	0		
MyoD	DNA binding protein; RNA splicing; Transcription factor	P15172	4654	MYOD1	11p15.4	human	T115	PHOSPHORYLATION	452044	ADRRKAAtMRERRRL	HLH	activity, inhibited				3983	2	0	0		
E4BP4	DNA binding protein; Transcription factor	Q90Z72	395326	NFIL3		chicken	S182	PHOSPHORYLATION	452016	CISVIKHsPQSSMSD	Vert_IL3-reg_TF	protein degradation				3929	1	0	0		
DEF6	Guanine nucleotide exchange factor, Rac/Rho	Q8C2K1	23853	Def6		mouse	Y144	PHOSPHORYLATION	479006	MVPDEVEyLLKKLLG		activity, induced; intracellular localization	cell differentiation, altered; transcription, altered			5960907	1	0	1		
TRPC5	Channel, cation; Membrane protein, integral; Membrane protein, multi-pass	Q9QX29	22067	Trpc5		mouse	T972	PHOSPHORYLATION	455597	DGQEEQVtTRL____		receptor desensitization, altered				5538	1	0	0	required for desensitization after stimulation by carbachol	
NHERF	Adaptor/scaffold; Motility/polarity/chemotaxis	P70441	26941	Slc9a3r1		mouse	S77	PHOSPHORYLATION	957200	ETHQQVVsRIRAALN	PDZ	molecular association, regulation		SLC34A1(DISRUPTS)		13354717; 1172818	4	0	0		
PKCB	EC 2.7.11.13; KINASE; Kinase, protein; Motility/polarity/chemotaxis; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor)	P05771	5579	PRKCB	16p11.2	human	T642	PHOSPHORYLATION	447897	TRQPVELtPTDKLFI	Pkinase_C	intracellular localization				1173027	18	28	43	Requires dual phosphorylation to locate to pericentrion.	
NUP98 iso2	Motility/polarity/chemotaxis; Nucleoporin	P52948-2	4928	NUP98	11p15.5	human	S494	PHOSPHORYLATION	18330803	HINSLTYsPFGDSPL		intracellular localization				18331300	1	1	1	as multiple sites (13PM) mutant 	
HDAC7	EC 3.5.1.98; Hydrolase	Q8WUI4	51564	HDAC7	12q13.1	human	S155	PHOSPHORYLATION	455620	FPLRKTVsEPNLKLR		intracellular localization; phosphorylation	cell motility, altered; cytoskeletal reorganization; transcription, altered; cell growth, altered			7397635; 3886811; 5506; 9006	7	11	32	important for VEGF-induced aorta ring angiogenesis; nucleo-cytoplasmic shuttling	
Ikaros	C2H2-type zinc finger protein; DNA binding protein; Transcription factor	Q03267	22778	Ikzf1		mouse	T23	PHOSPHORYLATION	4828303	ESPPVSDtPDEGDEP		molecular association, regulation; intracellular localization			DNA(DISRUPTS)	4615812	1	0	0		
DYN1	EC 3.6.5.5; Hydrolase; Microtubule binding protein; Motility/polarity/chemotaxis; Motor protein; Vesicle protein	P21575	140694	Dnm1		rat	Y354	PHOSPHORYLATION	450400	SGDQIDTyELSGGAR	Dynamin_M	molecular association, regulation; protein conformation				2461	1	2	26	Tyrosine phosphorylation promotes DYN1 self assembly.	
ITGA4	Cell adhesion; Membrane protein, integral; Motility/polarity/chemotaxis; Receptor, misc.	P13612	3676	ITGA4	2q31.3	human	S1011	PHOSPHORYLATION	7705801	FFKRQYKsILQEENR	Integrin_alpha	molecular association, regulation		14-3-3 zeta(INDUCES)		7543539	1	1	0		
caldesmon	Actin binding protein	Q05682	800	CALD1	7q33	human	S759	PHOSPHORYLATION	448465	KTPDGNKsPAPKPSD	Caldesmon	molecular association, regulation; intracellular localization; protein conformation	cell motility, altered; cytoskeletal reorganization	ACTA1(DISRUPTS)		8353; 12778807; 7289	7	9	0		
MKK3	EC 2.7.12.2; KINASE; Kinase, protein; Protein kinase, STE; Protein kinase, dual-specificity	P46734	5606	MAP2K3	17q11.2	human	S218	PHOSPHORYLATION	448276	ISGYLVDsVAKTMDA	Pkinase	enzymatic activity, induced	transcription, induced			2852638; 715	14	8	46		
STIM1	Calcium-binding protein; Endoplasmic reticulum; Membrane protein, integral	P70302	20866	Stim1		mouse	S575	PHOSPHORYLATION	468876	LVEKLPDsPALAKKT		molecular association, regulation; protein conformation		ORAI1(INDUCES); EB1(INDUCES)		28100400; 28023923	5	32	12	calcium mobilization and EB1-dependent STIM1 multimerization ; regulate store operated calcium entry (SOCE)	
WAVE2	Actin binding protein; Motility/polarity/chemotaxis	Q9Y6W5	10163	WASF2	1p36.11	human	S497	PHOSPHORYLATION	6377639	EFDEDDWsD______		activity, inhibited	cytoskeletal reorganization			6337810	1	1	1		
AQP2	Channel, misc.; Membrane protein, integral; Membrane protein, multi-pass	P56402	11827	Aqp2		mouse	S256	PHOSPHORYLATION	449854	REVRRRQsVELHSPQ		activity, induced; protein stabilization; molecular association, regulation; intracellular localization; phosphorylation	exocytosis, altered; endocytosis, altered	HSC70(DISRUPTS); ANXA2(DISRUPTS); ACTG1(DISRUPTS)		6331328; 7833; 12728102; 3301212	48	7	0		
ezrin	Cytoskeletal protein; Motility/polarity/chemotaxis	P15311	7430	EZR	6q25.3	human	Y478	PHOSPHORYLATION	454875	PPPPPPVyEPVSYHV	ERM	molecular association, regulation	cell motility, altered; cytoskeletal reorganization	WWOX(INDUCES); Fes(INDUCES); KCTD15(INDUCES)		1172868; 7446; 4337	5	2	132		
TRPC6	Channel, cation; Membrane protein, integral; Membrane protein, multi-pass	Q61143	22068	Trpc6		mouse	T69	PHOSPHORYLATION	470868	RLTHRRQtILREKGR		activity, inhibited				14562609; 3309526; 13354715	9	2	6		
PKD1	Autophagy; EC 2.7.11.13; KINASE; Kinase, protein; Motility/polarity/chemotaxis; Protein kinase, CAMK; Protein kinase, Ser/Thr (non-receptor)	Q15139	5587	PRKD1	14q11	human	Y95	PHOSPHORYLATION	764000	KFPECGFyGMYDKIL		molecular association, regulation; enzymatic activity, induced		PKCD(INDUCES)		762717	1	0	0		
H2B	DNA binding protein	P10853	319187	Hist1h2bn		mouse	S37	PHOSPHORYLATION	449903	RKRSRKEsYSVYVYK	Histone		transcription, induced			15658708	6	6	37	S37 phosphorylation essential for cell survival in response to metabolic stress.	
ER-alpha	DNA binding protein; Nuclear receptor	P03372	2099	ESR1	6q25.1	human	Y52	PHOSPHORYLATION	12620701	DSSKPAVyNYPEGAA	Oest_recep	protein stabilization	carcinogenesis, induced; cell growth, induced; transcription, induced			12558701	1	0	0		
GPIbB	Cell surface; Membrane protein, integral	P13224	2812	GP1BB	22q11.21	human	S191	PHOSPHORYLATION	456005	ARAAARLsLTDPLVA		molecular association, regulation; receptor desensitization, altered	cell adhesion, altered	14-3-3 zeta(INDUCES)		6570; 3252	4	9	0		
ALDOB	Carbohydrate Metabolism - fructose and mannose; Carbohydrate Metabolism - glycolysis and gluconeogenesis; Carbohydrate Metabolism - pentose phosphate pathway; EC 4.1.2.13; KINASE; Lyase	P79226	100328925	ALDOB		rabbit	Y362	PHOSPHORYLATION	451309	QSLFTASyTY_____	Glycolytic	enzymatic activity, inhibited				3528	1	0	1		
MBD4	Apoptosis; DNA repair; Deoxyribonuclease; EC 3.2.2.-	O95243	8930	MBD4	3q21.3	human	S262	PHOSPHORYLATION	22730000	SGFVQSDsKRESVCN		enzymatic activity, induced	DNA repair, induced			22723936	1	0	0		
IRS1	Adaptor/scaffold; Motility/polarity/chemotaxis	P35570	25467	Irs1		rat	S332	PHOSPHORYLATION	455323	SDGEGTMsRPASVDG		phosphorylation				4591	1	0	0	decreases tyrosine phosphorylation of IRS-1 and Akt1 phosphorylation upon insulin stimulation	
DBNL	Actin binding protein; Motility/polarity/chemotaxis	Q62418	13169	Dbnl		mouse	Y340	PHOSPHORYLATION	450090	QTEEEPTyEVPPEQD	PAT1		cytoskeletal reorganization			23260305	3	1	29	podosome dot, rosette formation, extracellular matrix degradation 	
IRAK1BP1	Transcription regulation	Q9ESJ7	65099	Irak1bp1		mouse	T236	PHOSPHORYLATION	12524611	QQKIKSAtIHAASKV	SIMPL	intracellular localization	transcription, altered			12482402	1	0	0	nuclear localization	
PXN	Adaptor/scaffold; Cell adhesion; Cytoskeletal protein; Motility/polarity/chemotaxis	P49024	395832	PXN		chicken	S190	PHOSPHORYLATION	471383	VIPESSSsAGGKAAP	Paxillin	protein stabilization	cell motility, altered			9110	2	1	0	promotes cell spreading by increasing the dynamics of membrane protrusions	
Huntingtin	Cytoskeletal protein	P42858	3064	HTT	4p16.3	human	S430	PHOSPHORYLATION	2020881	LIAGGGSsCSPVLSR		protein stabilization				25348515	1	5	3	reduced cell viability and enhanced protein accumulation in S430A mutant	
VAV1	Guanine nucleotide exchange factor, Rac/Rho; Motility/polarity/chemotaxis	P15498	7409	VAV1	19p13.2	human	Y826	PHOSPHORYLATION	450351	GWWRGEIyGRVGWFP	SH3_1	activity, induced; molecular association, regulation	carcinogenesis, altered; cell growth, altered	Shc1(INDUCES); CSK(INDUCES); Abl(INDUCES); SH2D1A(INDUCES)		14551403	1	3	80		
CAMKK1	EC 2.7.11.17; KINASE; Kinase, protein; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor)	P97756	60341	Camkk1		rat	S74	PHOSPHORYLATION	452115	SLSARKFsLQERPAG		molecular association, regulation; enzymatic activity, inhibited; phosphorylation		14-3-3 gamma(INDUCES); 14-3-3 eta(INDUCES)		8358	3	6	7	binding of 14-3-3 leads to enzymatic inhibition and protection of CAMKK1 phospho-T108	
NKCC1	Membrane protein, integral; Membrane protein, multi-pass; Transporter	P55011	6558	SLC12A2	5q23.3	human	T203	PHOSPHORYLATION	467235	HQHYYYDtHTNTYYL	AA_permease_N	activity, induced				8161	4	0	0		
CLK2	EC 2.7.12.1; KINASE; Kinase, protein; Protein kinase, CMGC; Protein kinase, dual-specificity	O35491	12748	Clk2		mouse	S98	PHOSPHORYLATION	471940	YDTDFRQsYEYHREN		protein degradation				25779410	1	3	5		
PRDX6	Amino Acid Metabolism - phenylalanine; EC 1.11.1.15; EC 1.11.1.7; EC 1.11.1.9; EC 3.1.1.-; Energy Metabolism - methane; Oxidoreductase; Phospholipase	P30041	9588	PRDX6	1q25.1	human	T177	PHOSPHORYLATION	3823356	TAEKRVAtPVDWKDG	1-cysPrx_C	enzymatic activity, induced				6331311	2	2	9	in vitro	
ARAF	EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, Ser/Thr (non-receptor); Protein kinase, TKL	P10398	369	ARAF	Xp11.4-p11.2	human	S262	PHOSPHORYLATION	3306309	RGSPSPAsVSSGRKS		enzymatic activity, induced				3301229	1	1	0		
vimentin	Cytoskeletal protein; Motility/polarity/chemotaxis	P31000	81818	Vim		rat	S55	PHOSPHORYLATION	476052	TSRSLYSsSPGGAYV	Filament_head; DUF2464		cytoskeletal reorganization			5955627	4	8	28	Vimentin is phosphorylated during S55 during mitosis and is not affected by nestin. 	
KIF2C	Cancer Testis Antigen (CTA); Microtubule binding protein; Motility/polarity/chemotaxis; Motor protein	Q99661	11004	KIF2C	1p34.1	human	S192	PHOSPHORYLATION	2132102	VNSVRRKsCLVKEVE		intracellular localization; activity, inhibited	cytoskeletal reorganization			27132439; 3306	5	1	25	Inhibits its microtubule depolymerization activity	
ER-alpha	DNA binding protein; Nuclear receptor	P03372	2099	ESR1	6q25.1	human	S118	PHOSPHORYLATION	448101	LHPPPQLsPFLQPHG	Oest_recep	activity, induced; protein degradation; acetylation; molecular association, regulation; phosphorylation	carcinogenesis, altered; transcription, induced; transcription, altered; cell growth, altered	NCoA2(INDUCES); Src(INDUCES); TCF20(INDUCES); CBP(INDUCES); ERK2(INDUCES); SRC-3(INDUCES); PPP5C(INDUCES); SF3A1(INDUCES); P38A(INDUCES)	DNA(INDUCES)	7124711; 4560; 6092; 2315; 6110; 6091; 3565; 5400; 11006907; 1926900; 4671; 4734; 4894700; 7263; 7176; 12728104; 6685; 4254812; 7543509; 4888108; 9033; 4888109; 3342616	73	2	0	high phosphorylation correlated with benefit of tamoxifen treatment in patients	
Bcl-2	Apoptosis; Autophagy; Membrane protein, integral	P10417	12043	Bcl2		mouse	T69	PHOSPHORYLATION	448398	HRDMAARtSPLRPLV		protein stabilization	cell cycle regulation; apoptosis, inhibited			4558	8	0	0		
NUT	Unknown function	Q86Y26	256646	NUT	15q14	human	S1026	PHOSPHORYLATION	13165101	NFAYLLAsKLSLSPR		intracellular localization				12482422	1	0	0	nuclear-cytoplasmic shuttling	
Ikaros	C2H2-type zinc finger protein; DNA binding protein; Transcription factor	Q03267	22778	Ikzf1		mouse	S384	PHOSPHORYLATION	451349	VSSEREAsPSNSCQD		activity, inhibited	cell cycle regulation		DNA(DISRUPTS)	3559	1	2	4		
NRF2	DNA binding protein; Transcription factor	O54968	83619	Nfe2l2		rat	S40	PHOSPHORYLATION	450082	SREVFDFsQRQKDYE		activity, induced; molecular association, regulation	transcription, induced	KEAP1(DISRUPTS)		3805	8	0	0		
ZAP	RNA binding protein; Transferase	Q8K3Y6	252832	Zc3hav1		rat	S274	PHOSPHORYLATION	3203919	PLGSGPPsPDVTSCK		activity, induced				25227647	1	17	11		
MARK2	EC 2.7.11.1; EC 2.7.11.26; KINASE; Kinase, protein; Protein kinase, CAMK; Protein kinase, Ser/Thr (non-receptor)	CAB06295	60328	Mark2		rat	T208	PHOSPHORYLATION	449999	TFGNKLDtFCGSPPY	Pkinase	enzymatic activity, induced				2550; 6889	6	25	35		
Dok1	Adaptor/scaffold; Motility/polarity/chemotaxis	Q99704	1796	DOK1	2p13	human	S439	PHOSPHORYLATION	454882	EPGTATGsGIKSHNS		phosphorylation	cell motility, altered; cell growth, altered			4367	1	0	0		
Grb2	Adaptor/scaffold; Cell development/differentiation; Motility/polarity/chemotaxis	P62993	2885	GRB2	17q24-q25	human	Y37	PHOSPHORYLATION	7388001	EECDQNWyKAELNGK	SH3_1		cell growth, altered			7324303	1	0	0	regulates cell proliferation	
PLK4	EC 2.7.11.21; KINASE; Kinase, protein; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor)	Q64702	20873	Plk4		mouse	S291	PHOSPHORYLATION	12654010	DSGHATLsTTITASS		protein degradation; ubiquitination				12525201	1	1	0		
RCHY1	EC 6.3.2.-; EC 6.3.2.19; Nuclear receptor co-regulator; UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase	Q96PM5	25898	RCHY1	4q21.1	human	T217	PHOSPHORYLATION	27971903	PSEYQNMtVDILCND		ubiquitination; activity, inhibited	transcription, inhibited			27902309	1	0	0	self-ubiquitination, may contribute to p53-inhibition of transcriptional elongation of HIV-LTR 	
JNK1	EC 2.7.11.24; KINASE; Kinase, protein; Protein kinase, CMGC; Protein kinase, Ser/Thr (non-receptor)	P45983	5599	MAPK8	10q11.22	human	T183	PHOSPHORYLATION	447643	AGTSFMMtPYVVTRY	Pkinase	enzymatic activity, induced	apoptosis, altered; apoptosis, induced; cell adhesion, altered; transcription, altered			12482411; 7324138; 5884; 7036; 3278; 5121519	201	19	370		
N-CoR1	Nuclear receptor co-regulator; Transcription, coactivator/corepressor	O75376	9611	NCOR1	17p11.2	human	S1450	PHOSPHORYLATION	1210494	TVRSRHTsVVSSGPS		protein conformation	transcription, induced			28722431	1	5	42	N-CoR misfolding, Flt3 derepression	
SAMSN1	Adaptor/scaffold	Q9NSI8	64092	SAMSN1	21q11	human	S23	PHOSPHORYLATION	467324	QKPKRSSsFGNFDRF	SLY	molecular association, regulation; intracellular localization		14-3-3 beta(INDUCES); 14-3-3 gamma(INDUCES)		15571603	1	9	1		
PITPNB	Lipid binding protein	P53811	56305	Pitpnb		mouse	S165	PHOSPHORYLATION	451298	EDPALFHsVKTKRGP	IP_trans	activity, induced				3520	1	0	0		
PKCI	Cell adhesion; Cell development/differentiation; EC 2.7.11.13; EC 3.-.-.-; KINASE; Kinase, protein; Motility/polarity/chemotaxis; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor)	P41743	5584	PRKCI	3q26.3	human	Y430	PHOSPHORYLATION	482865	EILRGEDyGFSVDWW	Pkinase	protein conformation				11758	1	0	0		
Mos	EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor)	P00536	17451	Mos		mouse	S279	PHOSPHORYLATION	450040	DLRCRQAsPHHIGGT	Pkinase	activity, inhibited				2605	1	0	0		
Bcl-xL	Apoptosis; Autophagy; Membrane protein, integral; Mitochondrial	Q07817	598	BCL2L1	20q11.21	human	T47	PHOSPHORYLATION	448163	GTESEMEtPSAINGN			cell cycle regulation; apoptosis, altered; apoptosis, induced	CDK1(DISRUPTS)		9621; 928	3	0	0	A peptide surrounding T47 and S62 phosphorylation sites impeded inhibition of CDK1.  apoptotoc function of bcl-xl was not affected.  	
CEACAM1 iso8	Cell adhesion; Immunoglobulin superfamily; Membrane protein, integral; Motility/polarity/chemotaxis	P13688-8	634	CEACAM1	19q13.2	human	S459	PHOSPHORYLATION	3439800	LHFGKTGsSGPLQ__		phosphorylation	cell differentiation, altered			3433202	3	0	0	FAK Y397 phosphorylation	
AHCYL1	Amino Acid Metabolism - cysteine and methionine; EC 3.3.1.1; Hydrolase; Other Amino Acids Metabolism - selenoamino acid	Q80SW1	229709	Ahcyl1		mouse	T72	PHOSPHORYLATION	467248	RSISQSStDSYSSAA	Utp11	molecular association, regulation		IP3R1(INDUCES)		8190	1	1	1	binding to IP3R1 supresses its binding to IP3 and inhibits IP3-induced calcium release 	
CREM iso3	DNA binding protein; Transcription factor	P27699	12916	Crem		mouse	S284	PHOSPHORYLATION	450065	QGVVMAAsPGSLHSP		activity, inhibited	transcription, altered			2633	3	6	2		
KIF2C	Cancer Testis Antigen (CTA); Microtubule binding protein; Motility/polarity/chemotaxis; Motor protein	Q91636	380006	kif2c		frog	S719	PHOSPHORYLATION	3545002	LQVEEQAsKQISKKK		intracellular localization	cytoskeletal reorganization			3309528	1	0	0	facilitates bipolar spindle formation	
ER-alpha	DNA binding protein; Nuclear receptor	P19785	13982	Esr1		mouse	S171	PHOSPHORYLATION	448102	NGRERLSsSNEKGNM	Oest_recep	activity, induced	transcription, induced			1975601	34	3	0		
axin 1	Adaptor/scaffold	O35625	12005	Axin1		mouse	S157	PHOSPHORYLATION	27266401	LDSNGIVsRQTKPAT	RGS	molecular association, regulation	cell cycle regulation	TUBG1(DISRUPTS)		27257033	1	1	0	 S157A mutant leads to an increased number of multi-centrosome containing mitotic cells; regulates centrosome duplication	
ER-alpha	DNA binding protein; Nuclear receptor	P03372	2099	ESR1	6q25.1	human	S106	PHOSPHORYLATION	448100	PLNSVSPsPLMLLHP	Oest_recep	activity, induced; molecular association, regulation	transcription, induced; transcription, altered	NCoA2(INDUCES); Src(INDUCES); SRC-3(INDUCES); CBP(INDUCES)		5400; 4888108; 6685; 4254812	19	1	0		
DDX58	EC 3.6.1.-; EC 3.6.4.13; Hydrolase	O95786	23586	DDX58	9p12	human	T770	PHOSPHORYLATION	17484200	DSILRLQtWDEAVFR		molecular association, regulation; enzymatic activity, inhibited		DDX58(DISRUPTS)		17431516	1	1	0	dephosphorylation of T770, S855, S854 stimulates multimer formation;  	
ETV1	DNA binding protein; Transcription factor	P50549	2115	ETV1	7p21.3	human	S94	PHOSPHORYLATION	3059606	KIKKEPHsPCSEISS	ETS_PEA3_N	activity, induced	transcription, induced			8495	2	0	0		
mAChR M2	GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR	P08172	1129	CHRM2	7q31-q35	human	S311	PHOSPHORYLATION	459109	DENTVSTsLGHSKDE	7tm_1	receptor desensitization, altered; receptor internalization, altered				7628	3	0	0	Mutation of 4 S/T to A eliminates receptor desensitization in response to carbachol treatment (as measured by isoproterenol-stimulated cAMP production after pretreatment with carbachol).; Mutation of S286 T287 S288 S290 to A caused a faster rate and a greater extent of receptor internalization after agonist stimulation (transients only, not observed in stables).  Mutation of all 8 sites prevented internalization (in both transients and stables).	
LPCAT1	ACETYLTRANSFERASE; Acetyltransferase; EC 2.3.1.-; EC 2.3.1.23; EC 2.3.1.67; Endoplasmic reticulum; Membrane protein, integral	Q3TFD2	210992	Lpcat1		mouse	S178	PHOSPHORYLATION	17533100	RPVFVSRsDQDSRRK	Acyltransferase	protein degradation; ubiquitination				17431517	1	0	0		
EGFR	EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Protein kinase, TK; Protein kinase, tyrosine (receptor)	Q01279	13649	Egfr		mouse	Y871	PHOSPHORYLATION	448061	LGAEEKEyHAEGGKV	Pkinase_Tyr		transcription, altered			4207609	62	10	128		
G-alpha(11)	G protein; G protein, heterotrimeric; G protein, heterotrimeric alpha G(q)	P21278	14672	Gna11		mouse	Y356	PHOSPHORYLATION	448561	LQLNLKEyNLV____	G-alpha	activity, induced				2672; 1359	2	0	0	Authors do question whether it is phosphorylation since other bulky aromatic residues seem to work well at position Y356 (whereas less bulky and nonaromatic residues like alanine do not).	
Ago2	EC 3.1.26.n2; RNA processing	Q9UKV8	27161	EIF2C2	8q24	human	S387	PHOSPHORYLATION	472450	SKLMRSAsFNTDPYV		intracellular localization	translation, inhibited	TNRC6A(INDUCES)		2807215; 30280001	3	6	20	miRNA-mediated repression, P body localization of Ago2	
capicua	DNA binding protein; Transcription factor	Q96RK0	23152	CIC	19q13.2	human	S1409	PHOSPHORYLATION	453485	SAPEDPTsPKRKMRR		molecular association, regulation; intracellular localization		KPNA3(DISRUPTS)		17431533	1	12	24		
SCN5A	Channel, sodium; Membrane protein, integral; Membrane protein, multi-pass	Q14524	6331	SCN5A	3p21	human	S516	PHOSPHORYLATION	4719558	LSLTRGLsRTSMKPR	DUF3451	activity, inhibited				25227646	1	2	0		
GAPDH	Carbohydrate Metabolism - glycolysis and gluconeogenesis; EC 1.2.1.12; EC 2.6.99.-; Oxidoreductase	P04406	2597	GAPDH	12p13	human	K117	ACETYLATION	474648	AHLQGGAkRVIISAP	Gp_dh_N	intracellular localization				14772324	1	0	113	nuclear translocation	
p47phox	EC 1.-.-.-; Oxidoreductase	P14598	653361	NCF1	7q11.23	human	S345	PHOSPHORYLATION	451727	QARPGPQsPGSPLEE	p47_phox_C	activity, induced				8081	10	4	0	involved in GM-CSF- and TNFalpha-induced priming of neutrophils	
DAPK3	EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, CAMK; Protein kinase, Ser/Thr (non-receptor)	O54784	13144	Dapk3		mouse	T265	PHOSPHORYLATION	454892	KDPKRRMtIAQSLEH	Pkinase	enzymatic activity, induced	apoptosis, induced			7298	3	1	0	A T265A mutant is unable to activate STAT3 in response to IL-6 stimulation 	
NPM-ALK	Kinase, protein; Protein kinase, TK; Protein kinase, tyrosine (receptor)	AAA58698		NPM/ALK		human	Y567	PHOSPHORYLATION	27275100	TSLWNPTyGSWFTEK		molecular association, regulation	transcription, induced	Shc1(INDUCES); SNTB1(INDUCES)		3299; 2852671; 9127	3	2	0		
KLC2	Microtubule binding protein; Motor protein	Q9H0B6	64837	KLC2	11q13.2	human	S545	PHOSPHORYLATION	3892542	GSLRRSGsFGKLRDA		molecular association, regulation		14-3-3 beta(INDUCES)		21683737	1	4	10	mutation of this site prevents 14-3-3 binding (pan-14-3-3 antibody)	
SIK	EC 2.7.11.1; KINASE; Kinase, protein; Motility/polarity/chemotaxis; Protein kinase, CAMK; Protein kinase, Ser/Thr (non-receptor)	Q9R1U5	59329	Sik1		rat	S186	PHOSPHORYLATION	2560900	PLSTWCGsPPYAAPE	Pkinase	molecular association, regulation; enzymatic activity, induced		14-3-3 beta(INDUCES)		2560600	2	0	0	important for TORC2 phosphorylation and activation	
PIK3C2A	Autophagy; Carbohydrate Metabolism - inositol phosphate; EC 2.7.1.154; KINASE; Kinase, lipid; Motility/polarity/chemotaxis	O00443	5286	PIK3C2A	11p15.5-p14	human	S259	PHOSPHORYLATION	449059	KVSNLQVsPKSEDIS		protein degradation; protein conformation				2092	1	21	3		
Cdc25B	EC 3.1.3.48; Motility/polarity/chemotaxis; Nuclear receptor co-regulator; PHOSPHATASE; Protein phosphatase, dual-specificity	P30306	12531	Cdc25b		mouse	S351	PHOSPHORYLATION	452008	VQSKRRKsVTPLEEQ	M-inducer_phosp		cell cycle regulation			762702	7	5	9		
KCNMA1	Channel, potassium; Endoplasmic reticulum; Membrane protein, integral; Membrane protein, multi-pass	Q12791	3778	KCNMA1	10q22.3	human	S978	PHOSPHORYLATION	456598	PPGMDRSsPDNSPVH		activity, induced				8591	1	4	0		
p21Cip1	Cell cycle regulation; Inhibitor protein	P39689	12575	Cdkn1a		mouse	S78	PHOSPHORYLATION	14577356	GLPKVYLsPGSRSRD		activity, inhibited	apoptosis, altered			19084423	1	2	0	S78 phosphorylation limits p21 inhibition of Cdk2. S78 regulates apoptosis in response to cisplatin. 	
CD19	Cell surface; Membrane protein, integral	P25918	12478	Cd19		mouse	Y522	PHOSPHORYLATION	447639	HEEDADSyENMDKSD		activity, induced; molecular association, regulation	cell differentiation, altered	PIK3R1(INDUCES)		5862; 12482418	6	2	18	regulate Akt activation and B-cell differentiation through binding to PI3KR1	
MRE11A	Cell cycle regulation; DNA binding protein; DNA repair; Deoxyribonuclease	P49959	4361	MRE11A	11q21	human	S676	PHOSPHORYLATION	460788	TSSSKIMsQSQVSKG		molecular association, regulation			DNA(DISRUPTS)	11484420	1	3	12		
MOK	EC 2.7.11.22; KINASE; Kinase, protein; Protein kinase, CMGC; Protein kinase, Ser/Thr (non-receptor)	Q9WVS4	26448	Rage		mouse	Y161	PHOSPHORYLATION	450006	SKQPYTEyISTRWYR	Pkinase	activity, induced				2553	1	0	0	While the authors did not prove that these sites were phosphorylated, mutation of both T159 and Y161, located in the activation loop, abolished the enzymatic activity of the kinase.	
RKIP	Inhibitor protein	P30086	5037	PEBP1	12q24.23	human	S153	PHOSPHORYLATION	448755	RGKFKVAsFRKKYEL	PBP	molecular association, regulation; receptor desensitization, altered; receptor internalization, altered; phosphorylation		RAF1(DISRUPTS); GRK2(INDUCES)		2964; 2630612	5	8	1	decreases phosphorylation, internalization, and desensitization of VPAC2 receptor;  increases ERK activity	
FPR1	GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Motility/polarity/chemotaxis; Receptor, GPCR	P21462	2357	FPR1	19q13.4	human	S328	PHOSPHORYLATION	450847	ERALTEDsTQTSDTA		molecular association, regulation; receptor desensitization, altered; receptor internalization, altered		ARRB2(INDUCES)		7979; 3130	3	0	0		
PKD3	EC 2.7.11.13; KINASE; Kinase, protein; Protein kinase, CAMK; Protein kinase, Ser/Thr (non-receptor)	O94806	23683	PRKD3	2p21	human	S731	PHOSPHORYLATION	456755	ARIIGEKsFRRSVVG	Pkinase	intracellular localization; enzymatic activity, induced				5014002; 6867	2	6	13		
SEPT3	Cell cycle regulation; Cytoskeletal protein; Hydrolase	Q9WU34	56003	Sept3		rat	S91	PHOSPHORYLATION	453431	SQVSRKAsSWNREEK	Septin	intracellular localization				4144	1	0	1		
NEK2	EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor)	P51955	4751	NEK2	1q32.2-q41	human	T175	PHOSPHORYLATION	12574603	HDTSFAKtFVGTPYY	Pkinase	enzymatic activity, induced				12482404	1	2	0		
PTPRA iso2	EC 3.1.3.48; Membrane protein, integral; Motility/polarity/chemotaxis; PHOSPHATASE; Receptor protein phosphatase, tyrosine	P18433-2	5786	PTPRA	20p13	human	S204	PHOSPHORYLATION	447612	PLLARSPsTNRKYPP		molecular association, regulation; phosphorylation; enzymatic activity, induced	cell growth, altered	PIK3CB(INDUCES); Src(INDUCES); PKCD(INDUCES); Grb2(DISRUPTS)		1710; 6474	6	2	0	promotes PTPRA tyrosine phosphorylation	
RGS5	GTPase activating protein, RGS	O15539	8490	RGS5	1q23.1	human	S166	PHOSPHORYLATION	482845	HALMEKDsLPRFVRS	RGS	activity, induced; molecular association, regulation		G-alpha(13)(DISRUPTS)		11810	1	0	0	 increase intracellular Ca2+; GTPase activating function	
cortactin	Actin binding protein; Cytoskeletal protein; Motility/polarity/chemotaxis	Q60598	13043	Cttn		mouse	S418	PHOSPHORYLATION	447701	IEDRPPSsPIYEDAA			cell cycle regulation; cell motility, altered			2790302	11	51	179		
CCDC6	Apoptosis; Cytoskeletal protein	Q16204	8030	CCDC6	10q21	human	T427	PHOSPHORYLATION	4790792	PDKFKRPtPPPSPNT		protein degradation; molecular association, regulation		FBXW7(INDUCES)		27132403	1	1	1		
tau iso8	Cytoskeletal protein	P10636-8	4137	MAPT	17q21.1	human	S214	PHOSPHORYLATION	447929	GSRSRTPsLPTPPTR		molecular association, regulation; intracellular localization; protein conformation	cytoskeletal reorganization	WWOX(INDUCES); APOE(INDUCES); TUBB(INDUCES)		15331033; 5955609; 5955610; 2570805; 2587205; 17630402; 6115906; 10303912; 15658702	41	10	32		
osteopontin	Secreted; Secreted, signal peptide	P10451	6696	SPP1	4q22.1	human	S117	PHOSPHORYLATION	455736	DVDDTDDsHQSDESH	Osteopontin	molecular association, regulation; activity, inhibited			Other(INDUCES)	10425106	1	3	0	peptide with phosphorylated S117, S120, S123, S126 and S129 has increased binding to hydroxyapatite, and inhibits bone mineralization in vivo and in vitro 	
KCC2	Membrane protein, integral; Membrane protein, multi-pass; Transporter	Q9H2X9	57468	SLC12A5	20q13.12	human	T929	PHOSPHORYLATION	10045603	SAYTYEKtLVMEQRS		activity, inhibited				9985929	1	3	0		
FOXM1	DNA binding protein; Transcription factor	Q08050	2305	FOXM1	12p13	human	S638	PHOSPHORYLATION	10897610	KVGGLDFsPVQTSQG		protein stabilization	transcription, induced			22495316	2	3	0		
PKR	EC 2.7.10.2; EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor); Translation	P19525	5610	EIF2AK2	2p22-p21	human	T255	PHOSPHORYLATION	448086	DLPDMKEtKYTVDKR		enzymatic activity, induced				9075	2	0	0		
TrkA	EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Protein kinase, TK; Protein kinase, tyrosine (receptor)	P04629	4914	NTRK1	1q21-q22	human	Y757	PHOSPHORYLATION	449758	RACPPEVyAIMRGCW	Pkinase_Tyr	activity, induced				7401	3	0	0	mutation of site abolished phosphorylation and NGF-induced sensitization of VR1	
cytohesin 1	Guanine nucleotide exchange factor, ARF; Motility/polarity/chemotaxis	P97694	116691	Cyth1		rat	Y382	PHOSPHORYLATION	464074	AISRDPFyEMLAARK		activity, induced				26341761	1	0	145	myelination	
Tiam1	Guanine nucleotide exchange factor, Rac/Rho; Motility/polarity/chemotaxis	Q60610	21844	Tiam1		mouse	S231	PHOSPHORYLATION	468938	STCQRANsLGDLYAQ		molecular association, regulation		14-3-3 zeta(INDUCES)		11419330	1	23	6		
MOR-1	GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR	P33535	25601	Oprm1		rat	T370	PHOSPHORYLATION	447785	STRVRQNtREHPSTA		molecular association, regulation; receptor desensitization, altered; receptor internalization, altered; phosphorylation		ARR3(INDUCES); ARRB2(INDUCES)		2927; 1182; 27132404; 2807232	13	2	0		
FOXO1A	DNA binding protein; Nuclear receptor co-regulator; Transcription factor	Q12778	2308	FOXO1	13q14.1	human	S325	PHOSPHORYLATION	449114	SSNASTIsGRLSPIM		intracellular localization				3405; 1093	5	2	0		
SSBP3	Cell cycle regulation; DNA binding protein; Transcription regulation	Q9BWW4	23648	SSBP3	1p32.3	human	Y23	PHOSPHORYLATION	1806900	AREKLALyVYEYLLH		activity, induced; intracellular localization	transcription, induced			1713132	1	0	0		
SOX2	Cell development/differentiation; DNA binding protein; Transcription factor	P48432	20674	Sox2		mouse	T118	PHOSPHORYLATION	17490601	KYRPRRKtKTLMKKD	SOXp	activity, induced; protein stabilization	transcription, induced			17482913	1	0	0	plays a crucial role in somatic cell reprogramming	
DNAPK	DNA repair; EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, ATYPICAL; Protein kinase, Ser/Thr (non-receptor)	P78527	5591	PRKDC	8q11	human	S2612	PHOSPHORYLATION	448711	MFVETQAsQGTLQTR			chromatin organization, altered; cell growth, altered			9570	3	10	34	increases survival in ionizing radiation and repairing double strand DNA breaks	
ataxin-3 iso2	DNA repair; EC 3.4.19.12; EC 3.4.22.-; Protease; Transcription regulation; Ubiquitin-specific protease	P54252-2	4287	ATXN3	14q21	human	S335	PHOSPHORYLATION	9441001	SDLGDAMsEEDMLQA	OmpH; Dicty_REP; UIM	activity, induced; protein stabilization; intracellular localization	transcription, altered			9201021	1	0	0		
PCAF	ACETYLTRANSFERASE; Acetyltransferase; EC 2.3.1.48; Nuclear receptor co-regulator	Q92831	8850	KAT2B	3p24	human	K430	ACETYLATION	458986	ANPGEKRkMTDSHVL		enzymatic activity, induced				7551	1	0	0	in vitro	
P70S6KB	EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor); Translation	Q9UBS0	6199	RPS6KB2	11q13.2	human	S473	PHOSPHORYLATION	450071	PPSGTKKsKRGRGRP		intracellular localization				1982	1	0	0		
P130Cas	Adaptor/scaffold; Motility/polarity/chemotaxis	P56945	9564	BCAR1	16q23.1	human	Y664	PHOSPHORYLATION	448399	EGGWMEDyDYVHLQG	DUF3513		carcinogenesis, induced; cell motility, induced; cell adhesion, induced; cytoskeletal reorganization			25027306	6	2	24	P130Cas phosphorylation is important in development of peripheral adhesion complexes, oncogenic signaling, and cell migration. 	
AFAP	Adaptor/scaffold	Q8N556	60312	AFAP1	4p16	human	Y94	PHOSPHORYLATION	3891001	SSLPEGYyEEAVPLS		molecular association, regulation		Src(INDUCES)		4664	1	1	4	Src Y529F Src mutant	
COX1	EC 1.9.3.1; Energy Metabolism - oxidative phosphorylation; Membrane protein, integral; Membrane protein, multi-pass; Mitochondrial; Oxidoreductase	P00396		MT-CO1		cow	Y304	PHOSPHORYLATION	454437	MDVDTRAyFTSATMI	COX1; TM	enzymatic activity, inhibited				2798903; 4302	3	1	0		
AML3 iso5	DNA binding protein; Transcription factor	Q08775-5	12393	Runx2		mouse	S301	PHOSPHORYLATION	10892804	DPRQAQSsPPWSYDQ		activity, induced	transcription, induced			14562606	6	0	0		
TSC1	Motility/polarity/chemotaxis; Tumor suppressor	Q92574	7248	TSC1	9q34	human	T417	PHOSPHORYLATION	450279	SLPQATVtPPRKEER	Hamartin	molecular association, regulation; intracellular localization	apoptosis, altered	TSC2(INDUCES); HSP70(INDUCES)		12028117	2	0	0		
K18	Cytoskeletal protein	P05783	3875	KRT18	12q13	human	S53	PHOSPHORYLATION	447734	ISVSRSTsFRGGMGS		protein processing; intracellular localization	cytoskeletal reorganization			1030; 7958; 9010; 2834	14	5	9	implicated in reorganization of intermediate filaments; S52 phosphorylation increases during S and G2/M stages of the cell cycle. Phosphorylated S52 is preferentially found in reorganized  filaments and in specific cellular domains.  	
ENaC-beta	Channel, sodium; Membrane protein, integral; Membrane protein, multi-pass	P37090	24767	Scnn1b		rat	T613	PHOSPHORYLATION	451219	QTLPIPGtPPPNYDS		molecular association, regulation; activity, inhibited		NEDD4L(DISRUPTS)		7683; 3454	4	0	0		
SPT5	Transcription, coactivator/corepressor	O00267	6829	SUPT5H	19q13	human	T806	PHOSPHORYLATION	458819	TPHYGSQtPLHDGSR	CTD		transcription, altered			7460	1	3	38	required for c-fos induction and activation in vivo	
PLM	Cell surface; Channel, misc.; Membrane protein, integral	O08589	58971	Fxyd1		rat	S88	PHOSPHORYLATION	451425	RSSIRRLsTRRR___	IncA	activity, induced; activity, inhibited				1910516; 7543537	21	1	74		
DYN1	EC 3.6.5.5; Hydrolase; Microtubule binding protein; Motility/polarity/chemotaxis; Motor protein; Vesicle protein	P21575	140694	Dnm1		rat	Y231	PHOSPHORYLATION	447605	LLPLRRGyIGVVNRS	Dynamin_M	molecular association, regulation; receptor internalization, altered; protein conformation; activity, inhibited				2461; 1058	3	1	0	Y231/597F mutant Inhibits B2-AR internalization, and inhibited the isoproterenol mediated activation of ERK2.; Tyrosine phosphorylation promotes DYN1 self assembly.	
BCAP	Adaptor/scaffold	Q9EQ32	83490	Pik3ap1		mouse	Y264	PHOSPHORYLATION	12520500	CETTVSYyTDMEEIG		molecular association, regulation	cell differentiation, altered	PIK3R1(INDUCES)		12482418	1	0	0	regulate Akt activation and B-cell differentiation through binding to PI3KR1	
tau iso8	Cytoskeletal protein	P10636-8	4137	MAPT	17q21.1	human	S356	PHOSPHORYLATION	449104	RVQSKIGsLDNITHV	Tubulin-binding	molecular association, regulation; protein conformation	cytoskeletal reorganization			12254; 10303912; 19084437	19	12	0		
MEKK2	EC 2.7.11.25; KINASE; Kinase, protein; Protein kinase, STE; Protein kinase, Ser/Thr (non-receptor)	Q61083	26405	Map3k2		mouse	S520	PHOSPHORYLATION	1869000	LSGTGMKsVTGTPYW	Pkinase	molecular association, regulation		14-3-3 epsilon(INDUCES)		28722174	2	2	0	14-3-3 binding reduces S520 phosphorylation	
FOXO3A	Autophagy; DNA binding protein; Transcription factor	O43524	2309	FOXO3	6q21	human	T32	PHOSPHORYLATION	448602	QSRPRSCtWPLQRPE		molecular association, regulation; intracellular localization; activity, inhibited	transcription, altered	14-3-3 beta(INDUCES)		2996900; 13320405	57	4	80		
P70S6KB	EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor); Translation	Q9Z1M4	58988	Rps6kb2		mouse	S423	PHOSPHORYLATION	455991	SSPRTPIsPLKFSPF		phosphorylation				1172822	2	7	35		
PKACA	EC 2.7.11.11; KINASE; Kinase, protein; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor)	P17612	5566	PRKACA	19p13.1	human	T198	PHOSPHORYLATION	448459	RVKGRTWtLCGTPEY	Pkinase	protein stabilization; protein conformation; enzymatic activity, induced				8739; 8738	20	27	258		
PLCG1	Carbohydrate Metabolism - inositol phosphate; EC 3.1.4.11; Motility/polarity/chemotaxis; Phospholipase	Q62077	18803	Plcg1		mouse	Y771	PHOSPHORYLATION	448575	IGTAEPDyGALYEGR			cell cycle regulation; cell motility, altered			2790302	12	30	546		
MAOA	Amino Acid Metabolism - arginine and proline; Amino Acid Metabolism - glycine, serine and threonine; Amino Acid Metabolism - histidine; Amino Acid Metabolism - phenylalanine; Amino Acid Metabolism - tryptophan; Amino Acid Metabolism - tyrosine; EC 1.4.3.4; Membrane protein, integral; Oxidoreductase; Xenobiotic Metabolism - drug metabolism - cytochrome P450	P21397	4128	MAOA	Xp11.3	human	S209	PHOSPHORYLATION	9726600	GGTTRIFsVTNGGQE	Amino_oxidase	protein degradation; enzymatic activity, inhibited; protein conformation				9721211; 9721222	1	0	0	S209E mutation reduces the stability of non-membrane bound form of MAOA	
Bax	Apoptosis; Membrane protein, integral; Mitochondrial	Q07812	581	BAX	19q13.3-q13.4	human	S184	PHOSPHORYLATION	451017	VAGVLTAsLTIWKKM	TM	activity, induced; intracellular localization; activity, inhibited	apoptosis, inhibited			6073; 970023	5	0	0		
RORA iso2	DNA binding protein; Nuclear receptor	P35398-2	6095	RORA	15q22.2	human	S35	PHOSPHORYLATION	12613703	ETPLNQEsARKSEPP		molecular association, regulation	cell motility, altered; cell growth, altered	CTNNB1(INDUCES)	DNA(INDUCES)	12558705	1	1	0	downregulates the Wnt signaling 	
RFA2	DNA replication	P15927	6118	RPA2	1p35	human	S8	PHOSPHORYLATION	470083	MWNSGFEsYGSSSYG		intracellular localization	cell cycle regulation; apoptosis, induced; cell growth, altered			21690611; 9042; 3335906; 2451816	16	1	0	 inhibits homologous recombination; delays mitotic entry	
StAR	Carrier protein; Lipid binding protein; Mitochondrial	P70114		STAR		hamster	S194	PHOSPHORYLATION	450442	RCAKRRGsTCVLAGI	START	enzymatic activity, induced				8830	7	0	0		
MKK6	EC 2.7.12.2; KINASE; Kinase, protein; Protein kinase, STE; Protein kinase, dual-specificity	P52564	5608	MAP2K6	17q24.3	human	T211	PHOSPHORYLATION	448195	LVDSVAKtIDAGCKP	Pkinase	enzymatic activity, induced	transcription, induced			715	2	2	1		
MEK2	EC 2.7.12.2; KINASE; Kinase, protein; Protein kinase, STE; Protein kinase, dual-specificity	P36507	5605	MAP2K2	19p13.3	human	S216	PHOSPHORYLATION	455802	KLCDFGVsGQLIDSM	Pkinase	enzymatic activity, inhibited				5672	2	1	3		
PKCD	EC 2.7.10.2; EC 2.7.11.13; KINASE; Kinase, protein; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor)	P28867	18753	Prkcd		mouse	Y155	PHOSPHORYLATION	447575	IKQAKIHyIKNHEFI	DUF4206	protein degradation; molecular association, regulation; intracellular localization	cell cycle regulation; apoptosis, induced; apoptosis, inhibited; cell growth, altered	KPNA2(INDUCES)		22518516; 8742; 1713115; 5240; 1243	7	0	0	Y155F mutant showed higher growth rate. ; PKCD-induced apoptosis	
ASF1A	DNA repair; Histone-binding protein	Q9Y294	25842	ASF1A	6q22.31	human	S192	PHOSPHORYLATION	12671900	GWSTSENsLNVMLES		protein stabilization; ubiquitination				12662608	1	1	0	inhibits ubiquitination and degradation	
TRPV5	Channel, cation; Membrane protein, integral; Membrane protein, multi-pass; Motility/polarity/chemotaxis	Q9XSM3		Trpv5		rabbit	T709	PHOSPHORYLATION	4710939	WEILRRNtLGHLNLG		activity, induced				7910515	2	2	0		
ANPB	EC 4.6.1.2; Guanylyl cyclase; KINASE; Kinase, protein; Lyase; Membrane protein, integral; Nucleotide Metabolism - purine; Protein kinase, RGC; Protein kinase, dual-specificity; Receptor, misc.	P16067	116564	Npr2		rat	T516	PHOSPHORYLATION	450026	KGAGSRLtLSLRGSS		activity, induced				2568	2	1	0		
GNRHR2	GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR	Q95MG6	100399755	LOC100399755		monkey	S338	PHOSPHORYLATION	454393	HQELSMDsSREEGSR		receptor internalization, altered				4259	1	0	0		
CROCC iso2	Cytoskeletal protein	Q5TZA2-2	9696	CROCC	1p36.13	human	S763	PHOSPHORYLATION	14159744	APRPVPGsPARDAPA			carcinogenesis, induced; cell growth, induced; signaling pathway regulation			25348513	1	5	4		
MEK1	EC 2.7.12.2; KINASE; Kinase, protein; Protein kinase, STE; Protein kinase, dual-specificity	Q02750	5604	MAP2K1	15q22.1-q22.33	human	T286	PHOSPHORYLATION	448286	VEGDAAEtPPRPRTP	Pkinase	enzymatic activity, inhibited; phosphorylation				4218; 1816	6	3	16	inhibits phosphorylation of ERK	
DARPP-32	Motility/polarity/chemotaxis; Protein phosphatase, regulatory subunit	Q9UD71	84152	PPP1R1B	17q12	human	T34	PHOSPHORYLATION	448047	MIRRRRPtPAMLFRL	DARPP-32; Drc1-Sld2		cell motility, altered; cytoskeletal reorganization			11554706	53	4	43		
EGR1	C2H2-type zinc finger protein; DNA binding protein; Transcription factor	P18146	1958	EGR1	5q31.1	human	T148	PHOSPHORYLATION	11423703	PAPNSGNtLWPEPLF	DUF3446		transcription, altered		DNA(DISRUPTS)	10274604	1	0	0		
NR0B2	Nuclear receptor co-regulator; Transcription, coactivator/corepressor	Q62227	23957	Nr0b2		mouse	K123	UBIQUITINATION	7596702	PVPSILKkILLEEAS	Hormone_recep	protein degradation				7543519	1	0	0		
Chk2	EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, CAMK; Protein kinase, Ser/Thr (non-receptor)	O96017	11200	CHEK2	22q12.1	human	S516	PHOSPHORYLATION	448840	PQVLAQPsTSRKRPR		enzymatic activity, induced				2928; 2236	10	3	0		
CAMK2A	EC 2.7.11.17; KINASE; Kinase, protein; Protein kinase, CAMK; Protein kinase, Ser/Thr (non-receptor)	Q9UQM7	815	CAMK2A	5q32	human	T253	PHOSPHORYLATION	451571	DLINKMLtINPSKRI	Pkinase		cytoskeletal reorganization			12558733	6	6	0		
N-WASP	Adaptor/scaffold; Motility/polarity/chemotaxis	O08816	682507	Wasl		rat	T196	PHOSPHORYLATION	23003801	KAKKKRLtKADIGTP		molecular association, regulation; protein conformation	cytoskeletal reorganization			22958935	1	0	0	 inhibits actin polymerization in vitro; inhibits the filopodia promoting activity of N-WASP	
SLCO1A1	Membrane protein, integral; Transporter	P46720	50572	Slco1a1		rat	S634	PHOSPHORYLATION	460719	QFPGDIDsSATDHTE		molecular association, regulation; intracellular localization		PDZK1(INDUCES)		17675048	1	1	0	plasma membrane distribution of SLCO1A1 requires interaction of its unphosphorylated form with PDZK1	
ROMK iso2	Channel, potassium; Membrane protein, integral; Membrane protein, multi-pass	P35560-2		Kcnj1		rat	S294	PHOSPHORYLATION	2461200	ATCQVRTsYVPEEVL	IRK	activity, induced				2462000	5	0	0	phosphorylation of at least two serines necessary for channel activity	
RFA2	DNA replication	P15927	6118	RPA2	1p35	human	S12	PHOSPHORYLATION	1854602	GFESYGSsSYGGAGG		intracellular localization	cell growth, altered			9042	3	1	0	7xAlanine mutant has defect in down regulating DNA synthesis following UV treatment. 7xAspartate mutant did not localize to S-phase foci.	
FOXC2	Apoptosis; Cell development/differentiation; DNA binding protein; Transcription factor	Q99958	2303	FOXC2	16q24.1	human	S240	PHOSPHORYLATION	3210585	PESALQGsPRSAAST		molecular association, regulation	transcription, altered		DNA(INDUCES)	28129300	1	13	0	implicated in vascular remodeling  in vivo	
phosducin	G protein regulator, misc.	P20942	25343	Pdc		rat	S73	PHOSPHORYLATION	451205	ERMSRKMsIQEYELI	Phosducin; SPK	molecular association, regulation; protein conformation		GNB1(DISRUPTS); 14-3-3 zeta(INDUCES); G-gamma(2)(DISRUPTS)		7077; 10144212; 27258203	7	1	0	Phosphorylation at S54 and S73 induce a structural change in the whole phosducin molecule in complex formation with 14-3-3. 	
OSMR	Membrane protein, integral; Receptor, cytokine	Q99650	9180	OSMR	5p13.1	human	Y861	PHOSPHORYLATION	458403	ICFENLTyNQAASDS		molecular association, regulation; phosphorylation	transcription, altered; cell growth, altered	Shc1(INDUCES)		8694; 7466	3	0	6	required for ERK1/2, p38 and JNK activation; ERK activation	
PLK1	EC 2.7.11.21; KINASE; Kinase, protein; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor)	P53350	5347	PLK1	16p12.2	human	S326	PHOSPHORYLATION	5393500	LTIPPRFsIAPSSLD		enzymatic activity, induced	cell cycle regulation			5354443	1	0	0		
Kv1.2	Channel, potassium; Membrane protein, integral; Membrane protein, multi-pass	P63142	25468	Kcna2		rat	S441	PHOSPHORYLATION	1818103	SCPKIPSsPDLKKSR		intracellular localization				1713111	1	6	0		
BAD	Apoptosis	Q92934	572	BAD	11q13.1	human	S118	PHOSPHORYLATION	447863	GRELRRMsDEFVDSF	Bcl-2_BAD; Bclx_interact		apoptosis, altered; apoptosis, inhibited	14-3-3 beta(INDUCES); Bcl-xL(DISRUPTS)		21697400; 6115915; 22722005	43	28	136		
caldesmon	Actin binding protein	P12957	373965	CALD1		chicken	S672	PHOSPHORYLATION	456706	EGVRNIKsMWEKGNV	Caldesmon	molecular association, regulation		calmodulin(DISRUPTS)		15571612	5	0	0		
NDFIP2	Adaptor/scaffold; Membrane protein, integral; Membrane protein, multi-pass	Q9NV92	54602	NDFIP2	13q31.1	human	Y167	PHOSPHORYLATION	3973278	TTSDTEVyGEFYPVP	DUF2370	phosphorylation				25779412	1	0	0	Y167, Y177 and Y186 phosphorylation are dependent on Y171 phosphorylation.	
RARA	DNA binding protein; Nuclear receptor; Transcription factor	P10276	5914	RARA	17q21	human	S77	PHOSPHORYLATION	455459	EIVPSPPsPPPLPRI		activity, induced; protein degradation; molecular association, regulation; protein conformation	transcription, inhibited; transcription, altered	N-CoR1(INDUCES); SRC-3(DISRUPTS); CCNH(INDUCES); Pin1(INDUCES)	DNA(INDUCES)	19084427; 3686; 8767; 12021337; 5216	8	0	0	suppression of this site phosphorylation links cell cycle G1 arrest to cell differentiation	
DAB1 iso2	Adaptor/scaffold	P97318-2	13131	Dab1		mouse	S400	PHOSPHORYLATION	479417	TNDSARSsPQSDKPR		phosphorylation				11449	3	0	0	inhibits tyrosine phosphorylation	
RAF1	EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, Ser/Thr (non-receptor); Protein kinase, TKL	P04049	5894	RAF1	3p25	human	T481	PHOSPHORYLATION	1811400	IFLHEGLtVKIGDFG	Pkinase_Tyr	enzymatic activity, induced				6878	1	2	0	 mutation of T481 is less profound of an effect.  B-Raf S579 shows similar effects to Raf1 S471.; Mutation of Raf1 S471 abolishes kinase activity and EGF-induced activity	
EPS8	Adaptor/scaffold	Q08509	13860	Eps8		mouse	S624	PHOSPHORYLATION	7101206	ADTPSAPsPPPTPAP		intracellular localization	cytoskeletal reorganization			9158114	1	5	0		
CRMP-2	Microtubule binding protein; Motility/polarity/chemotaxis	O08553	12934	Dpysl2		mouse	T514	PHOSPHORYLATION	454386	SVTPKTVtPASSAKT			cell growth, altered			15755122	17	14	36		
PLD1	EC 3.1.4.4; Lipid Metabolism - ether lipid; Lipid Metabolism - glycerophospholipid; Motility/polarity/chemotaxis; Phospholipase	P70496	25096	Pld1		rat	T147	PHOSPHORYLATION	448573	PIPTKRHtFRRQNVK	PX	intracellular localization; enzymatic activity, induced	exocytosis, altered			4313626; 5121515	5	0	0	Phosphorylation occurs in caveolin-enriched membrane fraction and is localized to the plasma membrane in cells.; T147-p is required for PLD1 mediated PA production and exocytosis.	
PEA-15	Apoptosis; Motility/polarity/chemotaxis	Q62048	18611	Pea15		mouse	S116	PHOSPHORYLATION	450281	KDIIRQPsEEEIIKL		molecular association, regulation	cell cycle regulation	ERK1(DISRUPTS); ERK2(DISRUPTS)		5780	8	46	1052		
Bcr	EC 2.7.11.1; GTPase activating protein, Rac/Rho; KINASE; Kinase, protein; Protein kinase, ATYPICAL; Protein kinase, Ser/Thr (non-receptor)	P11274	613	BCR	22q11.23	human	Y328	PHOSPHORYLATION	447795	FEDCGGGyTPDCSSN		enzymatic activity, induced				1749	2	0	0		
CENTG1 iso2	GTPase activating protein, ARF; Motility/polarity/chemotaxis	Q99490-2	116986	AGAP2	12q14.1	human	S279	PHOSPHORYLATION	478561	YSSSLPSsPNVGHRE		molecular association, regulation; enzymatic activity, induced	cell motility, altered	Akt1(DISRUPTS)		2807216	1	0	20		
ITGB1	Cell adhesion; Cell surface; Membrane protein, integral; Motility/polarity/chemotaxis; Receptor, misc.	P05556	3688	ITGB1	10p11.2	human	Y795	PHOSPHORYLATION	447711	TTVVNPKyEGK____	Integrin_b_cyt	molecular association, regulation		kindlin-2(DISRUPTS); tensin 1(NOT_REPORTED)		2848001; 15658712	6	10	223		
LHX3	DNA binding protein; Transcription factor	Q9UBR4	8022	LHX3	9q34.3	human	S234	PHOSPHORYLATION	455298	YFRNMKRsRGGSKSD		activity, induced	transcription, induced			4438	1	0	0	no change in binding to DNA or to certain proteins (NLI, PIT1, or MRG1)	
PINK1	EC 2.7.11.1; KINASE; Kinase, protein; Membrane protein, integral; Mitochondrial; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor)	Q9BXM7	65018	PINK1	1p36	human	S228	PHOSPHORYLATION	25792200	MWNISAGsSSEAILN		intracellular localization				25712624	3	1	0	promotes mitochondrial localization of parkin	
CLTB	Vesicle protein	P09497	1212	CLTB	5q35	human	S205	PHOSPHORYLATION	25592003	LCDFNPKsSKQCKDV	Clathrin_lg_ch		endocytosis, induced	CHCHD1(INDUCES)		25573549	1	0	0	discriminator for endocytosis of a subset of cargoes	
FOXG1	DNA binding protein; Transcription factor	P55316	2290	FOXG1	14q13	human	T279	PHOSPHORYLATION	482881	KLRRRSTtSRAKLAF		intracellular localization				11771	2	0	0		
FRS2	Adaptor/scaffold	Q8C180	327826	Frs2		mouse	Y392	PHOSPHORYLATION	449785	NLDPMHNyVNTENVT		molecular association, regulation		Grb2(INDUCES)		1356	2	1	23		
CD44	Cell adhesion; Membrane protein, integral; Motility/polarity/chemotaxis; Receptor, misc.	P16070	960	CD44	11p13	human	S706	PHOSPHORYLATION	450988	LNGEASKsQEMVHLV	Bravo_FIGEY	activity, induced; molecular association, regulation; intracellular localization	cell motility, altered; transcription, induced	MMP9(DISRUPTS)		9721221; 3251; 25712627; 8050	10	25	25	nuclear localization	
IRF5	DNA binding protein; Transcription factor	Q13568	3663	IRF5	7q32	human	S435	PHOSPHORYLATION	26389900	EMFSGELsWSADSIR		activity, induced; intracellular localization	apoptosis, induced; transcription, induced			25779418; 25785429	3	1	0		
4E-T	Karyopherin; Nuclear import; Translation	Q9NRA8	56478	EIF4ENIF1	22q11.2	human	S587	PHOSPHORYLATION	454357	YLRPRIPsPIGFTPG	EIF4E-T	molecular association, regulation		4E-T(INDUCES)		26341738	1	12	113	required for processing bodies (PBs or P bodies) assembly	
TXA2-R iso2	GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR	P21731-2	6915	TBXA2R	19p13.3	human	T399	PHOSPHORYLATION	451396	LLPFEPPtGKALSRK		receptor desensitization, altered				3597	1	0	0		
RXRA	DNA binding protein; Motility/polarity/chemotaxis; Nuclear receptor	P19793	6256	RXRA	9q34.3	human	T82	PHOSPHORYLATION	453096	HSMSVPTtPTLGFST	Nuc_recep-AF1	molecular association, regulation	transcription, inhibited	SRC-1(DISRUPTS)		14081213	3	0	0		
SLAM	Membrane protein, integral; Receptor, misc.	Q9QUM4	27218	Slamf1		mouse	Y315	PHOSPHORYLATION	448264	QDPCTTIyVAATEPA	Sarcoglycan_2; DUF3328	molecular association, regulation		Fyn(INDUCES)		1376	2	0	0		
LRP4	Cell surface; Membrane protein, integral; Receptor, misc.	Q9QYP1	83469	Lrp4		rat	S1900	PHOSPHORYLATION	465667	WKHERKLsSESQV__		molecular association, regulation		DLG1(DISRUPTS); PSD-95(DISRUPTS)		8078	1	1	4		
PAK6	EC 2.7.11.1; KINASE; Kinase, protein; Nuclear receptor co-regulator; Protein kinase, STE; Protein kinase, Ser/Thr (non-receptor)	Q9NQU5	56924	PAK6	15q14	human	S165	PHOSPHORYLATION	454427	MPWPEPQsPRVLPNG		enzymatic activity, induced				4293	1	1	0		
MRE11A	Cell cycle regulation; DNA binding protein; DNA repair; Deoxyribonuclease	P49959	4361	MRE11A	11q21	human	S264	PHOSPHORYLATION	486366	EQQLFYIsQPGSSVV		molecular association, regulation			DNA(DISRUPTS)	11484420	2	0	0		
PFKFB1	Carbohydrate Metabolism - fructose and mannose; EC 2.7.1.105; EC 3.1.3.46; Kinase, other; Motility/polarity/chemotaxis; Phosphatase (non-protein)	P07953	24638	Pfkfb1		rat	S33	PHOSPHORYLATION	456206	VLQRRRGsSIPQFTN	6PF2K	molecular association, regulation; intracellular localization; enzymatic activity, inhibited; enzymatic activity, induced			DNA(DISRUPTS)	3877; 8298; 6598	6	2	0	stimulates Fru-2,6-P2ase activity, inhibits 6PF2K activity	
SYT6	Membrane protein, integral; Vesicle protein	Q5T7P8	148281	SYT6	1p13.2	human	T418	PHOSPHORYLATION	456499	RLKKKKTtIKKNTLN	C2	activity, induced				6712	1	0	0		
APP iso4	Apoptosis; Cell surface; Membrane protein, integral; Receptor, misc.; Transcription factor	P05067-4	351	APP	21q21.3	human	S655	PHOSPHORYLATION	448200	LKKKQYTsIHHGVVE	APP_amyloid	protein processing	exocytosis, altered			7549216	4	0	0		
MEF2C iso3	DNA binding protein; Transcription factor	Q06413-3	4208	MEF2C	5q14.3	human	S387	PHOSPHORYLATION	1729600	TRHEAGRsPVDSLSS		activity, induced	transcription, altered			1160; 2273	2	1	0		
MARS	EC 6.1.1.10; Ligase; Other Amino Acids Metabolism - selenoamino acid; Translation	P56192	4141	MARS	12q13	human	S662	PHOSPHORYLATION	22496701	NRAGMFVsKFFGGYV		molecular association, regulation; enzymatic activity, inhibited; protein conformation	translation, inhibited	eEF1E1(DISRUPTS)		22463935	1	1	0		
restin	Cytoskeletal protein	Q9JK25	65201	Rsn		rat	S313	PHOSPHORYLATION	4769839	LKRSPSAsSLSSMSS		molecular association, regulation		TUBA1C(DISRUPTS)		15031338	1	2	0		
CACNG2	Channel, calcium; Membrane protein, integral; Membrane protein, multi-pass	Q71RJ2	84347	Cacng2		rat	T321	PHOSPHORYLATION	451273	NTANRRTtPV_____		molecular association, regulation		PSD-95(INDUCES); PSD-95(DISRUPTS)		5363; 12028112	3	0	0		
PPP2CA	EC 3.1.3.16; Motility/polarity/chemotaxis; PHOSPHATASE; Protein phosphatase, Ser/Thr (non-receptor)	P67775	5515	PPP2CA	5q31.1	human	L309	METHYLATION	3627520	RRTPDYFl_______		enzymatic activity, induced				9330	6	0	0		
PLCG1	Carbohydrate Metabolism - inositol phosphate; EC 3.1.4.11; Motility/polarity/chemotaxis; Phospholipase	P19174	5335	PLCG1	20q12-q13.1	human	Y783	PHOSPHORYLATION	447667	EGRNPGFyVEANPMP		molecular association, regulation; phosphorylation; enzymatic activity, induced	cell motility, altered	VEGFR2(INDUCES); Grb2(INDUCES)		7964; 5983; 2855903; 7188	59	25	542	necessary for EGF-induced association with Akt;  ; cCbl association with VEGFR2 is required for inhibition of PLCG1 phosphorylation. 	
OSMR	Membrane protein, integral; Receptor, cytokine	Q99650	9180	OSMR	5p13.1	human	Y917	PHOSPHORYLATION	1930200	AGETSLNyVSQLASP		phosphorylation				2704330	2	0	0	important for STAT3 activation	
CTNND2	Actin binding protein; Motility/polarity/chemotaxis	NP_001258431	114028	Ctnnd2		rat	S444	PHOSPHORYLATION	480954	RTSTAPSsPGVDSVP			cytoskeletal reorganization			5395101	1	7	1	mutation of site to alanine increases dendrite branching	
Btk	EC 2.7.10.2; KINASE; Kinase, protein; Protein kinase, TK; Protein kinase, tyrosine (non-receptor)	P35991	12229	Btk		mouse	S180	PHOSPHORYLATION	447577	GSLKPGSsHRKTKKP		intracellular localization; activity, inhibited				837	1	2	0		
DUOX1	EC 1.11.1.-; EC 1.6.3.1; Membrane protein, integral; Membrane protein, multi-pass; Oxidoreductase	Q9NRD9	53905	DUOX1	15q15.3	human	S1217	PHOSPHORYLATION	6370300	SHHFRRRsFRGFWLT	Ferric_reduct	enzymatic activity, inhibited				6331313	1	1	0		
PSMA7	EC 3.4.25.1; Protease; Proteasome complex	O14818	5688	PSMA7	20q13.33	human	Y153	PHOSPHORYLATION	456317	QTDPSGTyHAWKANA	Proteasome	enzymatic activity, inhibited	cell cycle regulation			7901	1	1	66		
GluR6	Channel, calcium; Channel, ligand-gated; Membrane protein, integral; Membrane protein, multi-pass	P42260	54257	Grik2		rat	S846	PHOSPHORYLATION	11496000	VGEFLYKsKKNAQLE		molecular association, regulation		14-3-3 theta(INDUCES)		28722149	3	0	0		
SIRT1	Apoptosis; DEACETYLASE; Deacetylase; EC 3.5.1.-; Nuclear receptor co-regulator	Q923E4	93759	Sirt1		mouse	S154	PHOSPHORYLATION	6006902	NGFHSCEsDDDDRTS		enzymatic activity, induced	apoptosis, inhibited			9980406	1	4	0	deacetylates p53 K382 and NFkB-p65	
eNOS	Amino Acid Metabolism - arginine and proline; EC 1.14.13.39; Oxidoreductase	P29474	4846	NOS3	7q36	human	S1179	PHOSPHORYLATION	467802	RIRTQSFsLQERQLR		enzymatic activity, induced	apoptosis, inhibited			1623	7	5	1		
p53	Activator protein; DNA binding protein; Motility/polarity/chemotaxis; Nuclear receptor co-regulator; Transcription factor; Tumor suppressor	P02340	22059	Tp53		mouse	S370	PHOSPHORYLATION	447570	LKTKKGQsTSRHKKT		acetylation				8707	12	0	0	substitution of either alanine or aspartic acid at this site abrogated p53 acetylation at K379 (K382 in human)	
OSBP	Lipid binding protein	P16258		OSBP		rabbit	Y396	PHOSPHORYLATION	2089800	DISLDEQyKHQLEET		activity, induced				1968352	1	1	0	Y396F mutant inhibits oxysterol-mediated phosphorylation and activation of Stat3	
LEPR	Membrane protein, integral; Receptor, cytokine	P48356	16847	Lepr		mouse	Y1138	PHOSPHORYLATION	448434	SGENFVPyMPQFQTC		activity, induced; molecular association, regulation; phosphorylation	transcription, induced; transcription, altered	SHP-2(INDUCES); STAT3(INDUCES)		4042519; 8809; 4449; 3515; 1620	15	0	0		
Rb	Nuclear receptor co-regulator; Transcription, coactivator/corepressor; Tumor suppressor	P13405	19645	Rb1		mouse	S773	PHOSPHORYLATION	447978	STRPPTLsPIPHIPR	Rb_C	molecular association, regulation		E2F1(DISRUPTS)		1258	56	9	112		
STF-1	Nuclear receptor	P33242	26423	Nr5a1		mouse	S203	PHOSPHORYLATION	447603	EYPEPYAsPPQQPGP		activity, induced; molecular association, regulation; protein conformation	transcription, altered	SMRT(INDUCES); GRIP1(INDUCES)		5451; 5354430; 1289	9	0	0		
Myc	DNA binding protein; Transcription factor	P01108	17869	Myc		mouse	S373	PHOSPHORYLATION	450961	RRNELKRsFFALRDQ	HLH	molecular association, regulation; activity, inhibited	cell cycle regulation; apoptosis, inhibited; transcription, altered; transcription, inhibited; cell growth, altered	MAX(DISRUPTS)		12524163; 3233	4	0	0	mutation of this site enhances epidermal differentiation	
DRP1	Apoptosis; EC 3.6.5.5; Endoplasmic reticulum; Hydrolase; Microtubule binding protein; Mitochondrial; Motor protein	O00429	10059	DNM1L	12p11.21	human	S616	PHOSPHORYLATION	454690	PIPIMPAsPQKGHAV		intracellular localization	apoptosis, induced			17675061	9	36	112	increases mitochondrial fragmentation	
Crk	Adaptor/scaffold; Motility/polarity/chemotaxis	P46108	1398	CRK	17p13.3	human	Y251	PHOSPHORYLATION	456549	QKRVPNAyDKTALAL	SH3_2	molecular association, regulation; enzymatic activity, induced		Arg(INDUCES); STAP1(INDUCES); Shc2(INDUCES); SHIP-2(INDUCES); Abi-1(INDUCES)		21687202	1	7	296	Crk activates Abl through phospho-Y251.	
TAL1	DNA binding protein; Transcription factor	P17542	6886	TAL1	1p32	human	S122	PHOSPHORYLATION	450663	DGRMVQLsPPALAAP		protein degradation				3498	2	3	76		
RCC1	Guanine nucleotide exchange factor, Ras	P18754	1104	RCC1	1p36.1	human	S11	PHOSPHORYLATION	452007	KRIAKRRsPPADAIP		molecular association, regulation; intracellular localization	cytoskeletal reorganization; cell growth, altered	KPNA4(DISRUPTS)		2831773; 762723; 3915	3	21	9		
p73	DNA binding protein; Transcription factor	Q9JJP2	22062	Tp73		mouse	T11	PHOSPHORYLATION	7437802	TSSSSSStFEHLWSS		molecular association, regulation	transcription, induced	p300(INDUCES)		7313809	1	0	0		
IRF7	DNA binding protein; Transcription factor	Q92985	3665	IRF7	11p15.5	human	S487	PHOSPHORYLATION	1276100	LCLSSANsLYDDIEC			transcription, inhibited			8586	2	0	0		
SIK	EC 2.7.11.1; KINASE; Kinase, protein; Motility/polarity/chemotaxis; Protein kinase, CAMK; Protein kinase, Ser/Thr (non-receptor)	Q9R1U5	59329	Sik1		rat	T322	PHOSPHORYLATION	990311	LGIDRQRtVESLQNS		enzymatic activity, induced				970047	1	0	0		
KCNJ13	Channel, potassium; Membrane protein, integral; Membrane protein, multi-pass	O60928	3769	KCNJ13	2q37	human	S201	PHOSPHORYLATION	6039502	TRPSPLTsVRVSAVL	IRK	activity, inhibited				5930008	1	0	0		
Cx43	Channel, misc.; Membrane protein, integral; Membrane protein, multi-pass; Motility/polarity/chemotaxis	P08050	24392	Gja1		rat	S369	PHOSPHORYLATION	459208	RPSSRASsRASSRPR		activity, induced; intracellular localization; protein conformation				4862617; 8412; 2016001	12	7	2	altered intracellular localization during cell cycle; BIM treatment in Rin43 cells and NRK-CT cells reduced multiple open states. In ischemic hearts Cx43 was uniformly distributed around each myocyte. ; gap junction/intercellular communication	
AurA	EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor)	A5GFW1		AURKA		pig	S283	PHOSPHORYLATION	3339003	GWSVHAPsSRRTTLC	Pkinase		cell cycle regulation			3309525	1	0	0		
PKCD	EC 2.7.10.2; EC 2.7.11.13; KINASE; Kinase, protein; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor)	Q05655	5580	PRKCD	3p21.31	human	Y64	PHOSPHORYLATION	447581	STFDAHIyEGRVIQI		activity, inhibited; phosphorylation	apoptosis, altered; apoptosis, induced			3522; 4264901	6	1	28	ERK phosphorylation/activation	
MEF2D	DNA binding protein; Transcription factor	Q63943	17261	Mef2d		mouse	S121	PHOSPHORYLATION	2246700	EDKYRRAsEELDGLF	HJURP_C	protein stabilization; molecular association, regulation; protein conformation; activity, inhibited	cell differentiation, altered; transcription, inhibited	HDAC4(INDUCES)		2195477	2	11	8	inhibits myogenesis	
TH	Amino Acid Metabolism - tyrosine; EC 1.14.16.2; Endoplasmic reticulum; Mitochondrial; Oxidoreductase; Vesicle protein	P04177	25085	Th		rat	S40	PHOSPHORYLATION	448545	RFIGRRQsLIEDARK	Chorion_2; TOH_N	protein stabilization; molecular association, regulation; protein conformation; enzymatic activity, induced				1801; 1173020; 802; 4592; 5381; 4082; 5751; 1307; 19084425; 803	46	6	11	S40 phosphorylation causes a more open conformation. 	
FAM125A	Adaptor/scaffold	Q96EY5	93343	FAM125A	19p13.11	human	S207	PHOSPHORYLATION	13211303	NDSIYEAsSLYGISA	DUF2464	protein processing				12660601	1	2	8	inhibition of HIV-1 release and infectivity	
galectin-3	Cell surface; Extracellular matrix; Motility/polarity/chemotaxis	P17931	3958	LGALS3	14q22.3	human	Y118	PHOSPHORYLATION	13213700	AGPLIVPyNLPLPGG	Gal-bind_lectin	protein stabilization	carcinogenesis, induced; apoptosis, altered			13164205	3	1	0		
IRS1	Adaptor/scaffold; Motility/polarity/chemotaxis	P35570	25467	Irs1		rat	Y895	PHOSPHORYLATION	447556	EPKSPGEyVNIEFGS		molecular association, regulation; phosphorylation		SHP-2(INDUCES); Grb2(INDUCES)		3512; 2894	8	1	0		
ABCA1	Membrane protein, integral; Membrane protein, multi-pass; Transporter; Vesicle protein	O95477	19	ABCA1	9q31.1	human	S2054	PHOSPHORYLATION	455498	GGNKRKLsTAMALIG	ABC_tran	activity, induced				5341	1	0	0		
ERK2	EC 2.7.11.24; KINASE; Kinase, protein; Protein kinase, CMGC; Protein kinase, Ser/Thr (non-receptor)	P28482	5594	MAPK1	22q11.21	human	S248	PHOSPHORYLATION	6845000	LGILGSPsQEDLNCI	Pkinase	molecular association, regulation; intracellular localization		IPO7(INDUCES); NUP153(DISRUPTS)		6841100	2	0	0		
ANP32B	Chaperone	Q92688	10541	ANP32B	9q22.32	human	T244	PHOSPHORYLATION	456786	GEKRKREtDDEGEDD		intracellular localization	transcription, altered			6331307; 9152	2	24	152	regulates the nucleocytoplasmic translocation of CD83 mRNA and its expression; leads to the translocation of the protein from the nucleus to the cytoplasm;  required for efficient CD83 expression	
PSARL	Apoptosis; EC 3.4.21.105; Membrane protein, integral; Membrane protein, multi-pass; Mitochondrial; Protease	Q9H300	55486	PARL	3q27.1	human	S70	PHOSPHORYLATION	471332	RRSDPGTsGEAYKRS		protein processing				9119	1	1	0	involved in mitochondrial fragmentation	
IRF2	DNA binding protein; Transcription factor	P23906	16363	Irf2		mouse	Y109	PHOSPHORYLATION	478391	GNNAFRVyRMLPLSE	IRF; Heme_oxygenase	molecular association, regulation	transcription, induced	IRF8(INDUCES); PU.1(INDUCES); IRF2(INDUCES)		9577	1	0	0		
GRK2	EC 2.7.11.15; KINASE; Kinase, protein; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor)	P25098	156	ADRBK1	11q13.1	human	Y92	PHOSPHORYLATION	456873	FYEEIKKyEKLETEE	RGS	protein degradation; molecular association, regulation		G-alpha(q)(INDUCES)		8002; 8017	5	0	0		
VHL	Tumor suppressor; UBIQUITIN LIGASE; Ubiquitin ligase	P40337	7428	VHL	3p25.3	human	S43	PHOSPHORYLATION	15573202	EESGPEEsGPEELGA		protein degradation	transcription, altered			15331032	1	0	0	regulates p53 activity and degradation of HIF1A	
RARA	DNA binding protein; Nuclear receptor; Transcription factor	P11416	19401	Rara		mouse	S369	PHOSPHORYLATION	451381	YVRKRRPsRPHMFPK	Hormone_recep	activity, induced; protein degradation				3557; 6066703	7	0	0		
HSPC227	Adaptor/scaffold	Q9CZG9	72621	Pdzd11		mouse	Y7	PHOSPHORYLATION	462550	_MDNRIPyDDYPVVF		molecular association, regulation		DECR1(INDUCES); SERCA2(INDUCES); S100A4(INDUCES); MYH3(INDUCES); MRLC2(INDUCES)		1814200	0	4	45		
FBXO31	Cell cycle regulation; Ubiquitin conjugating system	Q5XUX0	79791	FBXO31	16q24.2	human	S278	PHOSPHORYLATION	13216200	LMKFIYTsQYDNCLT		protein stabilization				9401437	1	0	0		
JAK2	EC 2.7.10.2; KINASE; Kinase, protein; Protein kinase, TK; Protein kinase, tyrosine (non-receptor)	Q62120	16452	Jak2		mouse	Y966	PHOSPHORYLATION	462255	QICKGMEyLGTKRYI	Pkinase_Tyr	enzymatic activity, induced				13354701	3	3	3		
G-alpha(z)	Endoplasmic reticulum; G protein, heterotrimeric; G protein, heterotrimeric alpha G((i/o/t/z)); Nuclear envelope	P19086	2781	GNAZ	22q11.22	human	S27	PHOSPHORYLATION	451241	DRHLRSEsQRQRREI	G-alpha; DUF2951	activity, induced; protein conformation				8515; 11484423	4	0	2		
GluR6	Channel, calcium; Channel, ligand-gated; Membrane protein, integral; Membrane protein, multi-pass	P42260	54257	Grik2		rat	S715	PHOSPHORYLATION	451343	FMSSRRQsVLVKSNE	Lig_chan	activity, induced				3529	1	0	0	PKA-mediated phosphorylation increases the potentiation of the glutamate response.	
Cdc34	EC 6.3.2.19; Ligase; UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase	P49427	997	CDC34	19p13.3	human	S231	PHOSPHORYLATION	448654	FGDDEDDsGTEES__		intracellular localization				1868	2	0	0		
CENPJ	Cell cycle regulation; Microtubule binding protein; Transcription, coactivator/corepressor	Q9HC77	55835	CENPJ	13q12.12	human	S1109	PHOSPHORYLATION	460560	NPPRRSKsAPPRDLG		molecular association, regulation		14-3-3 gamma(INDUCES)		7658	1	0	0	association with 14-3-3 decreases in mitotic cells	
Src	EC 2.7.10.2; KINASE; Kinase, protein; Protein kinase, TK; Protein kinase, tyrosine (non-receptor)	P12931	6714	SRC	20q12-q13	human	S17	PHOSPHORYLATION	448231	DASQRRRsLEPAENV		enzymatic activity, induced				5309417	9	21	11	Src S16 phosphorylation is necessary and sufficient for Rap1 and Ras activation by isoproterenol. 	
Src	EC 2.7.10.2; KINASE; Kinase, protein; Protein kinase, TK; Protein kinase, tyrosine (non-receptor)	Q9WUD9	83805	Src		rat	Y530	PHOSPHORYLATION	448235	FTSTERQyQPGENL_		molecular association, regulation; enzymatic activity, inhibited	cell adhesion, altered	PTPRA(INDUCES)		6282	104	13	966		
GYS1	Carbohydrate Metabolism - starch and sucrose; EC 2.4.1.11; Transferase	P13834	100008660	GYS1		rabbit	S649	PHOSPHORYLATION	448239	VPPSPSLsRHSSPHQ	Glycogen_syn	enzymatic activity, inhibited				9217; 4917204	13	5	1		
Lyn	EC 2.7.10.2; KINASE; Kinase, protein; Protein kinase, TK; Protein kinase, tyrosine (non-receptor)	P25911	17096	Lyn		mouse	Y397	PHOSPHORYLATION	448695	RVIEDNEyTAREGAK	Pkinase_Tyr	enzymatic activity, induced		Bcr(NOT_REPORTED)		707	15	33	2047		
TWIST1	Cell development/differentiation; DNA binding protein; Inhibitor protein; Transcription regulation	Q15672	7291	TWIST1	7p21.2	human	S18	PHOSPHORYLATION	18899301	SPADDSLsNSEEEPD		protein stabilization	carcinogenesis, altered; cell motility, altered			18837506	1	0	0		
LPAR1	GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR	Q92633	1902	LPAR1	9q31.3	human	T236	PHOSPHORYLATION	2764301	FGYVRQRtMRMSRHS	7tm_1	activity, inhibited				2725513	1	0	0		
VRK1	EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, CK1; Protein kinase, Ser/Thr (non-receptor)	Q99986	7443	VRK1	14q32	human	S342	PHOSPHORYLATION	5938010	DDGKLDLsVVENGGL			cytoskeletal reorganization			5926302	2	1	0	necessary for Golgi fragmentation	
TrkB	EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Protein kinase, TK; Protein kinase, tyrosine (receptor)	Q63604	25054	Ntrk2		rat	S478	PHOSPHORYLATION	478364	SNDDDSAsPLHHISN			cytoskeletal reorganization			9592	2	2	0	dendritic growth	
GGA1	Adaptor/scaffold; Vesicle protein	Q9UJY5	26088	GGA1	22q13.31	human	S268	PHOSPHORYLATION	1245522	PTLFRLAsDTEDNDE	Ferritin; GAT	intracellular localization				8527	1	3	37		
MAP1B	Cytoskeletal protein; Motility/polarity/chemotaxis	P14873	17755	Map1b		mouse	S1260	PHOSPHORYLATION	454136	SLSPSPPsPIEKTPL			cytoskeletal reorganization			5211	3	36	17	induces a loss of stable microtubules	
Bcl-3	Apoptosis; Nuclear receptor co-regulator; Transcription regulation	P20749	602	BCL3	19q13.1-q13.2	human	K21	UBIQUITINATION	3627524	VDLRTRPkAAGLPGA		protein degradation	transcription, altered			4319	1	0	0		
DAPK3	EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, CAMK; Protein kinase, Ser/Thr (non-receptor)	O43293	1613	DAPK3	19p13.3	human	T225	PHOSPHORYLATION	454891	LGETKQEtLTNISAV	Pkinase	enzymatic activity, induced				4344	2	0	0		
Kv7.1	Channel, potassium; Membrane protein, integral; Membrane protein, multi-pass	P51787	3784	KCNQ1	11p15.5	human	T470	PHOSPHORYLATION	2999202	SSVRKSPtLLEVSMP	KCNQ_channel	activity, induced				8604	1	0	0		
CEACAM1	Cell adhesion; Immunoglobulin superfamily; Membrane protein, integral; Motility/polarity/chemotaxis	P31809	26365	Ceacam1		mouse	Y488	PHOSPHORYLATION	447777	NKVDDVAyTVLNFNS		molecular association, regulation; intracellular localization	cell growth, altered	Shc1(INDUCES)		1610; 3630	7	1	0		
PRMT5	Cell cycle regulation; EC 2.1.1.-; EC 2.1.1.125; METHYLTRANSFERASE; Methyltransferase; Methyltransferase, protein arginine; RNA processing	O14744	10419	PRMT5	14q11.2	human	Y297	PHOSPHORYLATION	18545702	NRPPPNAyELFAKGY	PRMT5	molecular association, regulation; enzymatic activity, inhibited	carcinogenesis, altered; cell growth, altered	PRMT5(DISRUPTS)		18410835	1	0	0	contributes to the mutant Jak2 V617F -induced myeloproliferative phenotype; negatively regulates hematopoietic stem/progenitor cell expansion and erythroid differentiation	
NF1 iso2	GTPase activating protein, Ras; Motility/polarity/chemotaxis; Tumor suppressor	P21359-2	4763	NF1	17q11.2	human	S2578	PHOSPHORYLATION	456016	HLRKVSVsESNVLLD		molecular association, regulation; activity, inhibited		14-3-3 beta(INDUCES)		6580	1	2	2		
MARCKS	Actin binding protein; Motility/polarity/chemotaxis	P26645	17118	Marcks		mouse	S156	PHOSPHORYLATION	447787	KRFSFKKsFKLSGFS	MARCKS	intracellular localization	carcinogenesis, induced; cell motility, altered			15027801	21	15	9		
p70S6K	EC 2.7.11.-; EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor); Translation	P23443	6198	RPS6KB1	17q23.1	human	T444	PHOSPHORYLATION	448358	RFIGSPRtPVSPVKF		molecular association, regulation; enzymatic activity, induced	cell cycle regulation; cell adhesion, altered	tau iso8(NOT_REPORTED)		2563; 4719; 4805; 4759; 5631; 7444	94	16	84		
HSPA9B	Chaperone	P38646	3313	HSPA9	5q31.1	human	S65	PHOSPHORYLATION	483968	IDLGTTNsCVAVMEG	HSP70	protein stabilization				12005	1	0	0	 ; phosphorylation of this site stabilizes HSPA9B, activates TTK and promotes centrosome re-duplication	
Casp2	Apoptosis; EC 3.4.22.-; EC 3.4.22.55; Protease	P42575	835	CASP2	7q34-q35	human	S340	PHOSPHORYLATION	10892800	DGKNHAGsPGCEESD	Peptidase_C14		apoptosis, altered			10353920	1	3	0		
CEP250	Cell cycle regulation	Q9BV73	11190	CEP250	20q11.22	human	S2392	PHOSPHORYLATION	4728455	AGLHHSLsHSLLAVA			cell cycle regulation			15235230	1	2	0		
Snail1	C2H2-type zinc finger protein; Transcription factor	O95863	6615	SNAI1	20q13.2	human	S96	PHOSPHORYLATION	455883	TSLSDEDsGKGSQPP	CAP_N	protein degradation; ubiquitination; intracellular localization	cell motility, altered; transcription, altered	FBW1B(INDUCES)		6066701; 6098000; 6376	4	0	0	Localization mediated by S107, S111, S115 and S119. 	
SCN2A	Channel, sodium; Membrane protein, integral; Membrane protein, multi-pass	P04775	24766	Scn2a		rat	Y1498	PHOSPHORYLATION	1046200	TEEQKKYyNAMKKLG		activity, inhibited				970058	1	0	0		
Daxx	Apoptosis; Nuclear receptor co-regulator; Transcription, coactivator/corepressor	Q9UER7	1616	DAXX	6p21.3	human	S184	PHOSPHORYLATION	10438000	QSPRTRGsRRQIQRL	Daxx	protein stabilization	apoptosis, induced			10353935	2	0	0	required for TNF alpha -dependent accumulation of Daxx in cells 	
MEKK4	EC 2.7.11.25; KINASE; Kinase, protein; Protein kinase, STE; Protein kinase, Ser/Thr (non-receptor)	Q9Y6R4	4216	MAP3K4	6q26	human	T1494	PHOSPHORYLATION	479428	KLKNNAQtMPGEVNS	Pkinase	enzymatic activity, induced				2852673	1	0	1		
CSFR	EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Protein kinase, TK; Protein kinase, tyrosine (receptor)	P07333	1436	CSF1R	5q32	human	Y561	PHOSPHORYLATION	450118	ESYEGNSyTFIDPTQ	Bravo_FIGEY	activity, induced; molecular association, regulation				4624; 6250; 2719	10	1	6	Mutation of site reduced CSF-1-mediated tyrosine phosphorylation of PP2A as well as ERK activation.	
p300	ACETYLTRANSFERASE; Acetyltransferase; EC 2.3.1.48; Motility/polarity/chemotaxis; Nuclear receptor co-regulator; Transcription, coactivator/corepressor	Q09472	2033	EP300	22q13.2	human	S106	PHOSPHORYLATION	14652802	GPGQVMAsQAQQSSP		molecular association, regulation; acetylation; protein stabilization; enzymatic activity, induced		NBS1(INDUCES)		17482923; 14562607	2	0	0	required for NBS1 stability; regulates stability of NBS1 and its recruitment into damaged DNA 	
CACNA1B	Channel, calcium; Membrane protein, integral; Membrane protein, multi-pass	Q02294	257648	Cacna1b		rat	S898	PHOSPHORYLATION	455281	ARPRRSHsKEAPGAD		activity, inhibited				8797	2	2	0	Phosphorylation by PKC prevents effects of syntaxin 1A on voltage dependent inactivation of N-type calcium channels. 	
PLSCR1	Calcium-binding protein; Membrane protein, integral	O15162	5359	PLSCR1	3q23	human	Y74	PHOSPHORYLATION	464050	PVYNQPVyNQPVGAA		molecular association, regulation		Shc1(INDUCES)		8749	2	0	1		
AurC	EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor)	O88445	20871	Aurkc		mouse	T175	PHOSPHORYLATION	469107	RRKTMCGtLDYLPPE	Pkinase	enzymatic activity, inhibited				8291	1	3	11	complex effects on enzymatic activity: mutation of T171 or T175 to alanine increases kinase activity, while double mutant is inactive.	
IGF1R	EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Protein kinase, TK; Protein kinase, tyrosine (receptor)	P08069	3480	IGF1R	15q26.3	human	Y1280	PHOSPHORYLATION	450101	GFREVSFyYSEENKL			cell differentiation, altered; cell growth, altered			2703	5	0	0	observed in quadruple mutant Y980/1280/1281/1346F	
MEK1	EC 2.7.12.2; KINASE; Kinase, protein; Protein kinase, STE; Protein kinase, dual-specificity	P31938	26395	Map2k1		mouse	S298	PHOSPHORYLATION	448284	RTPGRPLsSYGMDSR	Pkinase	molecular association, regulation	cell adhesion, altered; cell growth, altered	ERK2(INDUCES)		4914028	16	0	0		
NBS1	Cell cycle regulation; DNA repair	O60934	4683	NBN	8q21	human	S278	PHOSPHORYLATION	449968	VDTGITNsQTLIPDC		phosphorylation	cell cycle regulation; apoptosis, induced; chromatin organization, altered			8674; 8673; 3886805; 3335906	9	0	0	phosphorylation of RFA2; important for apoptosis induction; S phase checkpoint; telomere maintenance	
GUCY1A3	EC 4.6.1.2; Guanylyl cyclase; Lyase; Nucleotide Metabolism - purine; Receptor, misc.	Q8CJD2	497757	Gucy1a3		rat	S64	PHOSPHORYLATION	3647001	SHPQRKTsRNRVYLH		enzymatic activity, inhibited; phosphorylation				3309513	1	0	0	downregulates phosphorylation of VASP S239	
mAChR M2	GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR	P08172	1129	CHRM2	7q31-q35	human	S286	PHOSPHORYLATION	459101	EKESSNDsTSVSAVA	7tm_1	receptor internalization, altered				7628	3	0	0	Mutation of S286 T287 S288 S290 to A caused a faster rate and a greater extent of receptor internalization after agonist stimulation (transients only, not observed in stables).  Mutation of all 8 sites prevented internalization (in both transients and stables).	
PKCZ	EC 2.7.11.13; KINASE; Kinase, protein; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor)	P09217	25522	Prkcz		rat	T410	PHOSPHORYLATION	447510	GPGDTTStFCGTPNY	Pkinase	protein degradation; intracellular localization; enzymatic activity, induced	cytoskeletal reorganization; transcription, altered	TNNI1(INDUCES); desmin(INDUCES); TPM1(INDUCES); MYO1C(INDUCES); TNNT1(INDUCES)		1243600; 6582; 2794; 4735	41	4	8		
BRAF	EC 2.7.1.37; EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, Ser/Thr (non-receptor); Protein kinase, TKL	P15056	673	BRAF	7q34	human	S446	PHOSPHORYLATION	447804	KTLGRRDsSDDWEIP		molecular association, regulation; protein conformation; enzymatic activity, induced	cell growth, induced	HRas(INDUCES); BRAF(NOT_REPORTED)		2403301; 7119513; 5254	8	26	53		
CDH5	Cell adhesion; Membrane protein, integral; Motility/polarity/chemotaxis	P33151	1003	CDH5	16q22.1	human	S665	PHOSPHORYLATION	2562900	YDVSVLNsVRRGGAK	Cadherin_C	intracellular localization				2425203	2	0	0		
eNOS	Amino Acid Metabolism - arginine and proline; EC 1.14.13.39; Oxidoreductase	P29473	287024	NOS3		cow	S1179	PHOSPHORYLATION	447884	TSRIRTQsFSLQERH		acetylation; molecular association, regulation; phosphorylation; enzymatic activity, induced	cell motility, altered	HSP90A(INDUCES)		14825601; 5479; 1069; 9401416; 4861511; 4861515; 5695; 6214; 6219; 1386; 1835; 3256102; 4527	141	8	7	promotes vasodilation	
SRPK1	EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, CMGC; Protein kinase, Ser/Thr (non-receptor)	Q96SB4	6732	SRPK1	6p21.31	human	T326	PHOSPHORYLATION	25724401	ENPPNKMtQEKLEES	Pkinase	intracellular localization	RNA splicing, induced			25712626	1	1	0	translocation to the nucleus-regulation of E1A splicing	
PKCZ	EC 2.7.11.13; KINASE; Kinase, protein; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor)	Q05513	5590	PRKCZ	1p36.33-p36.2	human	Y417	PHOSPHORYLATION	14305100	TFCGTPNyIAPEILR	Pkinase	enzymatic activity, induced				14058625	1	0	0		
TTK	Cancer Testis Antigen (CTA); EC 2.7.12.1; KINASE; Kinase, protein; Protein kinase, Other; Protein kinase, dual-specificity	P33981	7272	TTK	6q13-q21	human	T675	PHOSPHORYLATION	487539	ANQMQPDtTSVVKDS	Pkinase	enzymatic activity, inhibited				4042509	4	1	0	in vitro	
HSL	EC 3.1.1.79; Lipase	Q05469	3991	LIPE	19q13.2	human	S855	PHOSPHORYLATION	448804	EPMRRSVsEAALAQP		molecular association, regulation; enzymatic activity, induced		FABP4(INDUCES)		3361004; 6702314	17	12	1		
p70S6K iso2	EC 2.7.11.-; EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor); Translation	P67999-2	83840	Rps6kb1		rat	S424	PHOSPHORYLATION	448357	GSPRTPVsPVKFSPG		activity, induced	cell growth, altered			6939	90	23	211	PI3K, Akt and mTOR activation are required for 5-HT-induced proliferatioin. Wortmanin LY294002 and NL-71-101 dose-dependently inhibited 5HT induced proliferation. 	
NFAT2	DNA binding protein; Transcription factor	O95644	4772	NFATC1	18q23	human	S172	PHOSPHORYLATION	465577	YRDPSCLsPASSLSS		intracellular localization	transcription, inhibited			8031	1	0	0		
SNAP23	Vesicle protein	O70377	64630	Snap23		rat	S120	PHOSPHORYLATION	455263	NVVSKQPsRITNGQP	SNAP-25; Use1; Fib_alpha		exocytosis, altered			15785207	3	2	0		
NKCC1	Membrane protein, integral; Membrane protein, multi-pass; Transporter	P55012	20496	Slc12a2		mouse	T205	PHOSPHORYLATION	455545	TNTYYLRtFGHNTMD	AA_permease_N	activity, induced				2858604; 17630301	10	6	12	Enzymatic activation by SLK3 requires two threonines separated by 4 amino acids. 	
HDAC2	DEACETYLASE; Deacetylase; EC 3.5.1.98; Nuclear receptor co-regulator; Transcription, coactivator/corepressor	P70288	15182	Hdac2		mouse	S394	PHOSPHORYLATION	449930	EDAVHEDsGDEDGED		enzymatic activity, induced				20507101	3	43	49		
PARK2	EC 6.3.2.-; EC 6.3.2.19; Ligase; UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase	O60260	5071	PARK2	6q25.2-q27	human	Y143	PHOSPHORYLATION	15624700	SPAGRSIyNSFYVYC		ubiquitination; enzymatic activity, inhibited				15562520	1	1	0	inhibits PARK2 autoubiquitination	
PARVA	Adaptor/scaffold; Motility/polarity/chemotaxis	Q9NVD7	55742	PARVA	11p15.3	human	S8	PHOSPHORYLATION	4270099	MATSPQKsPSVPKSP			signaling pathway regulation			26341729	1	12	0	matrix degradation/invasion	
lamin A/C	Cytoskeletal protein	P02545	4000	LMNA	1q22	human	S652	PHOSPHORYLATION	452607	SYLLGNSsPRTQSPQ		activity, induced; intracellular localization				4641430	1	9	0	nuclear lamin disassemby	
MafA	DNA binding protein; Transcription factor	Q8NHW3	389692	MAFA	8q24.3	human	S65	PHOSPHORYLATION	5403102	PCSSVPSsPSFCAPS		activity, induced	cell differentiation, altered; transcription, induced			12482241	5	0	0	activation of crystallin and NQO1 expression	
PTPRA	EC 3.1.3.48; Membrane protein, integral; Motility/polarity/chemotaxis; PHOSPHATASE; Receptor protein phosphatase, tyrosine	P18052	19262	Ptpra		mouse	S180	PHOSPHORYLATION	447611	QAGSHSNsFRLSNGR		enzymatic activity, induced	cytoskeletal reorganization			4651315	6	8	0	neurite outgrowth	
SAPAP1	Cytoskeletal protein	O14490	9229	DLGAP1	18p11.31	human	S406	PHOSPHORYLATION	456941	KLQIRSHsYLRAVSE		molecular association, regulation		PSD-95(INDUCES)		25229706	2	1	1	Fluorescence Polarization	
STXBP1	Vesicle protein	P61765	25558	Stxbp1		rat	T574	PHOSPHORYLATION	454395	IGSTHILtPQKLLDT	Sec1	molecular association, regulation		STX1A(DISRUPTS)		4232	2	0	0		
STAP2	Adaptor/scaffold	Q8R0L1	106766	Stap2		mouse	Y250	PHOSPHORYLATION	478353	PFLLDEDyEKVLGFV		activity, induced				9626	3	0	25	involved in the activation of STAT3	
MAX	DNA binding protein; Transcription factor	P61244	4149	MAX	14q23	human	S2	PHOSPHORYLATION	449307	______MsDNDDIEV	ATG16; Filament; Myosin_tail_1	activity, inhibited	transcription, altered			9408	4	12	0	phosphorylation-deficient mutant inhibits transcription more efficiently	
NDR2	EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor)	Q9Y2H1	23012	STK38L	12p11.23	human	T442	PHOSPHORYLATION	451133	DWVFLNYtYKRFEGL	Pkinase_C	phosphorylation; enzymatic activity, induced	cell growth, altered			7692; 3334; 7365	4	1	4		
NMDAR2B	Channel, calcium; Channel, ligand-gated; Membrane protein, integral; Membrane protein, multi-pass	Q00960	24410	Grin2b		rat	S1480	PHOSPHORYLATION	454415	EKLSSIEsDV_____	NMDAR2_C	molecular association, regulation; receptor internalization, altered		DLG3(DISRUPTS); PSD-95(DISRUPTS)		4281	1	0	0		
F3	Cell surface; Membrane protein, integral	P13726	2152	F3	1p22-p21	human	S290	PHOSPHORYLATION	451613	GQSWKENsPLNVS__	Baculo_11_kDa	intracellular localization; protein conformation; phosphorylation	cell motility, altered; cell growth, altered			2195478; 4427; 18410814; 13164211	8	0	0	promotes angiogenesis	
CD3Z	Membrane protein, integral; Receptor, misc.	P20963	919	CD247	1q24.2	human	Y153	PHOSPHORYLATION	455204	STATKDTyDALHMQA	ITAM	molecular association, regulation		PI4K2A(INDUCES)		7700	2	9	274		
eplin	Actin binding protein; Cytoskeletal protein; Motility/polarity/chemotaxis	Q9UHB6	51474	LIMA1	12q13	human	S362	PHOSPHORYLATION	455424	PVHPKPLsPDSRASS		protein degradation; ubiquitination	carcinogenesis, induced			27257057	2	30	81	E-cadherin down regulation, EMT	
Rad9	Apoptosis; Cell cycle regulation; DNA replication; Deoxyribonuclease; EC 3.1.11.2	Q99638	5883	RAD9A	11q13.1-q13.2	human	Y28	PHOSPHORYLATION	447825	SRIGDELyLEPLEDG	Rad9	molecular association, regulation	apoptosis, induced	Bcl-xL(INDUCES)		1624	1	0	0		
TAK1	EC 2.7.11.25; KINASE; Kinase, protein; Protein kinase, Ser/Thr (non-receptor); Protein kinase, TKL	O43318	6885	MAP3K7	6q15	human	T187	PHOSPHORYLATION	454704	CDIQTHMtNNKGSAA	Pkinase_Tyr	phosphorylation; enzymatic activity, induced	transcription, altered			14780521; 7549215; 4214825; 4448; 2624800; 4328	14	0	0	phosphorylation of p38	
Mnk1	EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, CAMK; Protein kinase, Ser/Thr (non-receptor); Translation	O08605	17346	Mknk1		mouse	S396	PHOSPHORYLATION	11507614	GLCSMKLsPPSKSRL		molecular association, regulation		ERK1(INDUCES)		10296912	1	1	0		
BRCA1	EC 6.3.2.-; Nuclear receptor co-regulator; Transcription, coactivator/corepressor; Tumor suppressor; UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase	P38398	672	BRCA1	17q21	human	S1191	PHOSPHORYLATION	10272402	GELSRSPsPFTHTHL		intracellular localization				9980402	2	4	3	promotes formation of BRCA1 foci	
Smad2	DNA binding protein; Transcription factor	Q15796	4087	SMAD2	18q21.1	human	S110	PHOSPHORYLATION	450144	SFSEQTRsLDGRLQV	MH1	molecular association, regulation; intracellular localization		Smad3(INDUCES)		2766	1	0	0		
lamin A/C	Cytoskeletal protein	P02545	4000	LMNA	1q22	human	S525	PHOSPHORYLATION	465453	NTWGCGNsLRTALIN	LTD		cytoskeletal reorganization			7523	2	0	0	affects perinuclear assembly, dissasembly of lamin 	
CCR5	GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Motility/polarity/chemotaxis; Receptor, GPCR; Receptor, cytokine	P51681	1234	CCR5	3p21.31	human	S349	PHOSPHORYLATION	448724	STGEQEIsVGL____		molecular association, regulation; receptor desensitization, altered; receptor internalization, altered; activity, inhibited		ARRB1(INDUCES); ARRB2(INDUCES)		2453; 17675020; 3438; 5346	6	0	0		
LSP1	Actin binding protein; Motility/polarity/chemotaxis	P33241	4046	LSP1	11p15.5	human	S252	PHOSPHORYLATION	479435	PKLARQAsIELPSMA	Caldesmon; DUF45	intracellular localization				11466	2	21	166	in chemotaxing neutrophils	
PPAR-alpha	DNA binding protein; Nuclear receptor	Q07869	5465	PPARA	22q13.31	human	S12	PHOSPHORYLATION	1789802	ESPLCPLsPLEAGDL			transcription, inhibited			18021032; 1713131	2	0	0		
caveolin-1	Adaptor/scaffold; Motility/polarity/chemotaxis; Nuclear receptor co-regulator	P41350	25404	Cav1		rat	Y14	PHOSPHORYLATION	448422	VDSEGHLyTVPIREQ		activity, induced; molecular association, regulation; intracellular localization	endocytosis, altered	RhoA(INDUCES)		9938525; 3249409; 620	35	28	794	activates fibronectin secretion; insulin receptor was endocytosed with Y14 phosphorylated caveolin-1	
ITGB3	Cell adhesion; Membrane protein, integral; Motility/polarity/chemotaxis	P05106	3690	ITGB3	17q21.32	human	S778	PHOSPHORYLATION	457413	PLYKEATsTFTNITY	Integrin_b_cyt	molecular association, regulation; protein conformation; activity, inhibited	cell motility, altered; cell adhesion, altered	ITGA4(DISRUPTS)		7075; 4641428	2	0	0		
myocardin	Cell development/differentiation; Transcription factor	Q8VIM5	214384	Myocd		mouse	S636	PHOSPHORYLATION	3627511	PQCSPQHsPLGGLKS			transcription, inhibited			6856	1	0	0		
STXBP1	Vesicle protein	P61764	6812	STXBP1	9q34.1	human	Y145	PHOSPHORYLATION	456431	LPYESQVySLDSADS	Sec1	molecular association, regulation		STX1A(INDUCES)		28723108	1	1	0		
Nur77	Apoptosis; DNA binding protein; Nuclear receptor	P22736	3164	NR4A1	12q13	human	S431	PHOSPHORYLATION	21697917	IPGFAELsPADQDLL	Hormone_recep	molecular association, regulation	cell cycle regulation; transcription, induced	Pin1(INDUCES)		21683712	1	0	0		
PKCZ	EC 2.7.11.13; KINASE; Kinase, protein; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor)	Q02956	18762	Prkcz		mouse	T560	PHOSPHORYLATION	447572	TSEPVQLtPDDEDVI	Pkinase_C	enzymatic activity, induced				5121506	10	4	0		
SP1	C2H2-type zinc finger protein; DNA binding protein; Transcription factor	P08047	6667	SP1	12q13.1	human	T453	PHOSPHORYLATION	448226	SGPIIIRtPTVGPNG		molecular association, regulation	transcription, induced; transcription, inhibited; transcription, altered	NFkB-p65(INDUCES)		4766; 13852001; 4682; 1717	6	0	0		
LLGL1	Cell adhesion; Cytoskeletal protein; Motility/polarity/chemotaxis	NP_032528	16897	Llgl1		mouse	S662	PHOSPHORYLATION	449917	LKKSLRQsFRRIRKS		intracellular localization				2469	2	5	8		
NFkB-p100	DNA binding protein; Transcription factor	Q00653	4791	NFKB2	10q24	human	S222	PHOSPHORYLATION	3193889	QPIHDSKsPGASNLK		molecular association, regulation	transcription, altered	REL(INDUCES); Bcl-3(DISRUPTS); NFkB-p100(DISRUPTS)		14551422	1	1	0		
Rb-like 1	Transcription, coactivator/corepressor; Tumor suppressor	P28749	5933	RBL1	20q11.2	human	S964	PHOSPHORYLATION	451297	MMDAPPLsPFPHIKQ	Rb_C	molecular association, regulation	cell growth, altered	E2F4(DISRUPTS)		3519; 5981	2	6	14		
ERF	DNA binding protein; Transcription factor	P50548	2077	ERF	19q13	human	S251	PHOSPHORYLATION	456968	PLSPFPVsPLAGPGS		intracellular localization	cell cycle regulation			6956; 6957	2	1	1		
DGKG	EC 2.7.1.107; Kinase, lipid; Lipid Metabolism - glycerolipid; Lipid Metabolism - glycerophospholipid; Motility/polarity/chemotaxis	P49620	25666	Dgkg		rat	S779	PHOSPHORYLATION	471078	PQKSSFFsLRRKSRS		enzymatic activity, induced				9013	1	3	1		
ADRB1	GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR	P08588	153	ADRB1	10q25.3	human	S312	PHOSPHORYLATION	469625	RAGKRRPsRLVALRE	7tm_1	molecular association, regulation; receptor desensitization, altered; receptor recycling, altered		DLG1(INDUCES)		8264; 9153; 9078	4	0	0	SAP97 serves as a bridge between ADRB1 and AKAP79/PKA complex	
CTNNB1	Actin binding protein; Cell adhesion; Motility/polarity/chemotaxis; Nuclear receptor co-regulator; Transcription factor	P35222	1499	CTNNB1	3p21	human	S246	PHOSPHORYLATION	469995	ALVKMLGsPVDSVLF	RIX1; Arm	molecular association, regulation		Pin1(INDUCES)		8927	1	0	0		
CDK1	EC 2.7.11.22; EC 2.7.11.23; KINASE; Kinase, protein; Motility/polarity/chemotaxis; Protein kinase, CMGC; Protein kinase, Ser/Thr (non-receptor)	P11440	12534	Cdk1		mouse	Y15	PHOSPHORYLATION	447610	EKIGEGTyGVVYKGR	Pkinase	enzymatic activity, inhibited	cell cycle regulation			12662604; 762702; 6545; 7991105	128	78	3867		
RARG	DNA binding protein; Nuclear receptor	P13631	5916	RARG	12q13	human	S79	PHOSPHORYLATION	455544	EMVPSSPsPPPPPRV		activity, induced	transcription, induced			8768	2	0	0	Transactivation of mRARb2 promoter	
HDAC2	DEACETYLASE; Deacetylase; EC 3.5.1.98; Nuclear receptor co-regulator; Transcription, coactivator/corepressor	P70288	15182	Hdac2		mouse	S424	PHOSPHORYLATION	467980	CDEEFSDsEDEGEGG		enzymatic activity, induced				20507101	3	35	35		
Akt1	EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor)	P31749	207	AKT1	14q32.32	human	T305	O-GlcNAc	25538002	EGIKDGAtMKTFCGT	Pkinase	enzymatic activity, inhibited; phosphorylation				25347053	1	1	0	suppresses Akt phosphorylation at T308 by disrupting its interaction with PDK1	
RAF1	EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, Ser/Thr (non-receptor); Protein kinase, TKL	P04049	5894	RAF1	3p25	human	S619	PHOSPHORYLATION	5822317	SLPKINRsASEPSLH		enzymatic activity, induced				7324122	1	2	1		
MFF	Membrane protein, integral; Mitochondrial	Q9GZY8	56947	MFF	2q36.3	human	S157	PHOSPHORYLATION	470754	LKRERSMsENAVRQN	Miff	molecular association, regulation		14-3-3 beta(INDUCES)		21683737	1	22	51	mutation of this site prevents 14-3-3 binding (pan-14-3-3 antibody)	
ARHGAP24	GTPase activating protein, Rac/Rho; Motility/polarity/chemotaxis	Q8N264	83478	ARHGAP24	4q22.1	human	S413	PHOSPHORYLATION	12518707	SVHKLDVsRSPPLMV		activity, induced	cytoskeletal reorganization			12482285	1	2	0	membrane blebbing	
Syk	EC 2.7.10.2; KINASE; Kinase, protein; Protein kinase, TK; Protein kinase, tyrosine (non-receptor)	Q64725	25155	Syk		rat	Y342	PHOSPHORYLATION	447659	LPMDTEVyESPYADP		enzymatic activity, induced				6013	9	7	114		
TREK-1	Channel, potassium; Membrane protein, integral; Membrane protein, multi-pass	P97438	16526	Kcnk2		mouse	S351	PHOSPHORYLATION	457099	TSVKRKLsAELAGNH		activity, induced				7269	1	0	1	increases open probability of the (K+) channel	
Smad4	DNA binding protein; Transcription, coactivator/corepressor	P97471	17128	Smad4		mouse	T276	PHOSPHORYLATION	449628	GSRTAPYtPNLPHHQ		intracellular localization	transcription, induced			2261	1	0	0		
ChREBP	Transcription factor	Q8VIP2	171078	Mlxipl		rat	S627	PHOSPHORYLATION	458375	SGSERRPsGDLNSIQ			transcription, altered			3592	2	6	0	inhibits the DNA-binding activity of ChREBP	
PTPRE	EC 3.1.3.48; Membrane protein, integral; Motility/polarity/chemotaxis; PHOSPHATASE; Protein phosphatase, tyrosine (non-receptor); Receptor protein phosphatase, tyrosine	P49446	19267	Ptpre		mouse	Y695	PHOSPHORYLATION	450705	FIDIFSDyANFK___		molecular association, regulation; enzymatic activity, induced	cell growth, altered	TUBA4A(INDUCES); PTPRE(DISRUPTS); Grb2(INDUCES)		12249; 11813; 3134	4	12	558	Binding to tubulin decreases the cyt-PTPRE phosphatase activity.; reduced dimerization of glycosylated PTPRE mediated by HER2; essential for activation of Src by dephosphorylation	
ChREBP	Transcription factor	Q8VIP2	171078	Mlxipl		rat	S196	PHOSPHORYLATION	451393	KKRLRKSsREGDFLA		molecular association, regulation; intracellular localization	transcription, altered	KPNA2(DISRUPTS)		3592; 3301223	5	4	1	inhibits nuclear localization of ChREBP under low glucose conditions	
SNCAIP	Vesicle protein	Q9Y6H5	9627	SNCAIP	5q23.2	human	S215	PHOSPHORYLATION	2873901	CVLSPVKsPHLRKAS		molecular association, regulation		Pin1(INDUCES)		2865404	0	0	0		
KCNK18	Channel, ligand-gated; Channel, potassium; Membrane protein, integral; Membrane protein, multi-pass	Q6VV64	332396	Kcnk18		mouse	S274	PHOSPHORYLATION	13383300	ELVLGRLsCSILSNL		activity, inhibited				13354719	2	0	0		
KSR2 iso2	KINASE; Kinase, protein; Protein kinase, Ser/Thr (non-receptor); Protein kinase, TKL	ABF74604	333050	Ksr2		mouse	S310	PHOSPHORYLATION	4721664	TALHRSKsHEFQLGN		molecular association, regulation; intracellular localization		14-3-3 beta(INDUCES)		7890600	1	3	0		
NFkB-p65	DNA binding protein; Nuclear receptor co-regulator; Transcription factor	Q04207	19697	Rela		mouse	S311	PHOSPHORYLATION	449966	RTYETFKsIMKKSPF		molecular association, regulation	apoptosis, inhibited; transcription, induced	p300(INDUCES)		2525	9	0	1		
MAP2 iso3	Cytoskeletal protein; Motility/polarity/chemotaxis	P15146-3	25595	Map2		rat	T262	PHOSPHORYLATION	450182	RTPGTPGtPSYPRTP			cytoskeletal reorganization			7325703	2	9	16	caused decrease in microtubule bundles	
EGFR	EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Protein kinase, TK; Protein kinase, tyrosine (receptor)	Q01279	13649	Egfr		mouse	Y1069	PHOSPHORYLATION	448056	EDAFLQRySSDPTGA		protein degradation; molecular association, regulation; phosphorylation	cell motility, altered; apoptosis, inhibited	Cbl(INDUCES)		2621602; 659; 6784	31	12	114	promotes phosphorylation of Cbl	
CACNA1D	Channel, calcium; Membrane protein, integral; Membrane protein, multi-pass	P27732	29716	Cacna1d		rat	S1816	PHOSPHORYLATION	6062701	AAHGKRPsIGDLEHV		activity, induced				5930025	1	0	0		
GABRG2	Channel, chloride; Channel, ligand-gated; Membrane protein, integral; Membrane protein, multi-pass	P22723	14406	Gabrg2		mouse	S365	PHOSPHORYLATION	486436	FVSNRKPsKDKDKKK	Neur_chan_memb	receptor desensitization, altered				970014	3	0	0		
SMN	RNA binding protein; RNA processing	Q16637	6606	SMN1	5q13.2	human	S28	PHOSPHORYLATION	454315	FRRGTGQsDDSDIWD	SMN	activity, induced; molecular association, regulation		SMN(INDUCES)		4361; 17482918	2	42	24	possible SMN oligomerization 	
Rb	Nuclear receptor co-regulator; Transcription, coactivator/corepressor; Tumor suppressor	P13405	19645	Rb1		mouse	S561	PHOSPHORYLATION	450021	SLAWLSDsPLFDLIK	RB_A	molecular association, regulation		E2F1(DISRUPTS)		1258	4	0	0		
ADRA2A	GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR	P22909	25083	Adra2a		rat	T373	PHOSPHORYLATION	467298	QNREKRFtFVLAVVI	7tm_1; CD99L2; T2SM	activity, inhibited				8218	1	0	0		
CCND2	Cell cycle regulation; Motility/polarity/chemotaxis	P30279	894	CCND2	12p13	human	T280	PHOSPHORYLATION	469202	DELDQAStPTDVRDI	Cyclin_C	protein degradation				11765	2	3	9		
p70S6K iso2	EC 2.7.11.-; EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor); Translation	P23443-2	6198	RPS6KB1	17q23.1	human	T389	PHOSPHORYLATION	448607	NQVFLGFtYVAPSVL	Pkinase_C	enzymatic activity, induced				4248207	301	1	1		
Nogo iso2	Cell development/differentiation; Endoplasmic reticulum; Inhibitor protein; Membrane protein, integral; Membrane protein, multi-pass; Motility/polarity/chemotaxis	Q9JK11-2		Rtn4		rat	S16	PHOSPHORYLATION	468313	LVSSSTDsPPRPPPA	FAM176; Nucleoplasmin	protein degradation	apoptosis, altered			1263900	1	23	1	Phosphorylation regulates clevage of Nogo B.	
BRAF	EC 2.7.1.37; EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, Ser/Thr (non-receptor); Protein kinase, TKL	P15056	673	BRAF	7q34	human	T599	PHOSPHORYLATION	447807	IGDFGLAtVKSRWSG	Pkinase_Tyr	molecular association, regulation; protein conformation; enzymatic activity, induced	cell differentiation, altered; transcription, altered; cell growth, altered	BRAF(NOT_REPORTED)		3313; 1746; 4264910; 5254; 6588	8	0	0		
Rb	Nuclear receptor co-regulator; Transcription, coactivator/corepressor; Tumor suppressor	P06400	5925	RB1	13q14.2	human	S608	PHOSPHORYLATION	447976	TAADMYLsPVRSPKK		molecular association, regulation; protein conformation		E2F1(DISRUPTS)		14146309; 777	7	6	30		
NPHS1	Cell adhesion; Immunoglobulin superfamily; Membrane protein, integral	Q9QZS7	54631	Nphs1		mouse	Y1208	PHOSPHORYLATION	469565	PGVWGPLyDEVQMDP		molecular association, regulation	cytoskeletal reorganization	Nck1(INDUCES)		2195712	10	1	0		
GCSFR	Membrane protein, integral; Receptor, cytokine	Q99062	1441	CSF3R	1p35-p34.3	human	Y767	PHOSPHORYLATION	451835	TSPGPGHyLRCDSTQ		molecular association, regulation; activity, inhibited		Shc1(INDUCES); SHIP(INDUCES); STAT3(INDUCES); CISH(INDUCES)		8404; 7745	2	0	0		
calnexin	Calcium-binding protein; Endoplasmic reticulum; Membrane protein, integral; Motility/polarity/chemotaxis	P35565	29144	Canx		rat	S563	PHOSPHORYLATION	456360	EEDGGTGsQDEEDSK	Bravo_FIGEY; Ycf1; DUF1510; TRAP_alpha	molecular association, regulation; activity, inhibited		SERCA2(INDUCES)		8315	5	44	44	inhibition of cytosolic Ca2+ waves 	
palladin	Cytoskeletal protein; Motility/polarity/chemotaxis	Q8WX93	23022	PALLD	4q32.3	human	S1118	PHOSPHORYLATION	468361	VRRPRSRsRDSGDEN			cell motility, altered; cytoskeletal reorganization			14821618	1	22	55		
GABRG2	Channel, chloride; Channel, ligand-gated; Membrane protein, integral; Membrane protein, multi-pass	Q6PW52	29709	Gabrg2		rat	S365	PHOSPHORYLATION	486436	FVSNRKPsKDKDKKK	Neur_chan_memb	intracellular localization				15562517	3	0	0	involved in dispersal of GABRG2 clusters	
TGFBR1	EC 2.7.11.30; KINASE; Kinase, protein; Membrane protein, integral; Protein kinase, Ser/Thr (receptor); Protein kinase, TKL; Receptor, misc.	Q64729	21812	Tgfbr1		mouse	S165	PHOSPHORYLATION	448244	VPNEEDPsLDRPFIS			apoptosis, induced; cell growth, altered			1303	2	3	0		
HSF1	DNA binding protein; Transcription factor	Q00613	3297	HSF1	8q24.3	human	S216	PHOSPHORYLATION	4668102	IPLMLNDsGSAHSMP		protein degradation; molecular association, regulation; ubiquitination; intracellular localization	cell cycle regulation	Cdc20(INDUCES)		12058800; 4641420	2	0	0	binding between HSF1 and Cdc20 increases in p53 -/- cells;  interaction of Cdc20 with HSF1 weakenes its interaction with Mad2 in the three-protein complex	
KIN	C2H2-type zinc finger protein; DNA replication	O60870	22944	KIN	10p15-p14	human	K135	MONO-METHYLATION	27278513	CKVDETPkGWYIQYI	Kin17_mid	intracellular localization			DNA(DISRUPTS)	29531700	1	2	1	relocalization from chromatin to cytosol 	
HDAC5	EC 3.5.1.98; Hydrolase	Q9UQL6	10014	HDAC5	17q21	human	S259	PHOSPHORYLATION	447995	FPLRKTAsEPNLKVR		molecular association, regulation; enzymatic activity, inhibited; intracellular localization	cell differentiation, altered; chromatin organization, altered; cell motility, altered; transcription, induced; transcription, altered	PKD1(DISRUPTS); HDAC3(DISRUPTS); 14-3-3 epsilon(INDUCES); TBL1X(DISRUPTS); TBL1XR1(DISRUPTS); PKD3(DISRUPTS); GPS2(DISRUPTS); 14-3-3 beta(INDUCES); SMRT(DISRUPTS); PKD2(DISRUPTS); N-CoR1(INDUCES)		17431525; 7397634; 3735502; 2581; 7119503; 9006	16	9	17	required for VEGF-induced nuclear export, transcription of MEF2 and in vitro angiogenesis	
pyrin		O15553	4210	MEFV	16p13.3	human	S208	PHOSPHORYLATION	455897	VRLRRNAsSAGRLQG		molecular association, regulation; intracellular localization		14-3-3 theta(INDUCES)		6362	1	0	2		
TH	Amino Acid Metabolism - tyrosine; EC 1.14.16.2; Endoplasmic reticulum; Mitochondrial; Oxidoreductase; Vesicle protein	P04177	25085	Th		rat	S31	PHOSPHORYLATION	448544	KQAEAVTsPRFIGRR	Chorion_2; TOH_N	protein stabilization; enzymatic activity, induced				5381; 4592; 4082; 1801	32	5	0		
SRC-3	ACETYLTRANSFERASE; Acetyltransferase; EC 2.3.1.48; Motility/polarity/chemotaxis; Nuclear receptor co-regulator; Transcription, coactivator/corepressor	Q9Y6Q9	8202	NCOA3	20q12	human	T1067	PHOSPHORYLATION	4252800	LLSNTDAtGLEEIDR	Nuc_rec_co-act	protein stabilization; molecular association, regulation		PSMA3(DISRUPTS)		4248206	1	0	0	some subset of these 8 residues	
MEKK2	EC 2.7.11.25; KINASE; Kinase, protein; Protein kinase, STE; Protein kinase, Ser/Thr (non-receptor)	Q9Y2U5	10746	MAP3K2	2q14.3	human	T524	PHOSPHORYLATION	1904501	GMKSVTGtPYWMSPE	Pkinase	phosphorylation; enzymatic activity, induced	transcription, altered			1903001	1	1	0	Mutation of S520A inhibits activation and is the key residue.  Double mutation of T522A,T524A reduces activation effect.  T522A seems to have the least effect of the three single mutations.  The triple STT to AAA mutation is akin to kinase dead.  Activation leads to Erk5 and JNKK2 phosphorylation/activation.	
PTEN	Carbohydrate Metabolism - inositol phosphate; EC 3.1.3.16; EC 3.1.3.48; EC 3.1.3.67; Motility/polarity/chemotaxis; Nuclear receptor co-regulator; PHOSPHATASE; Phosphatase, lipid; Tumor suppressor	P60484	5728	PTEN	10q23.3	human	T383	PHOSPHORYLATION	448315	HYRYSDTtDSDPENE		molecular association, regulation; protein stabilization; enzymatic activity, inhibited	cell differentiation, altered; cell motility, altered; transcription, altered	PTEN(INDUCES); PTEN(DISRUPTS); AIP1(DISRUPTS)		1252602; 7145; 767; 2670102; 6416; 2904	12	2	0	cell migration in embryo	
TRPM4	Membrane protein, integral; Membrane protein, multi-pass	Q8TD43	54795	TRPM4	19q13.33	human	S1145	PHOSPHORYLATION	12559511	RDKRESDsERLKRTS		activity, induced				12482290	1	0	0		
TLR4	Membrane protein, integral; Receptor, misc.	O00206	7099	TLR4	9q33.1	human	Y674	PHOSPHORYLATION	478360	YGRGENIyDAFVIYS		molecular association, regulation; phosphorylation	transcription, altered	IRAK1(DISRUPTS); MYD88(DISRUPTS)		9628	1	0	0	IRAK1 short form	
GRK2	EC 2.7.11.15; KINASE; Kinase, protein; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor)	Q99MK8	110355	Adrbk1		mouse	S670	PHOSPHORYLATION	447725	KMKNKPRsPVVELSK		molecular association, regulation	cell motility, altered	GIT1(DISRUPTS)		2425208	3	16	17	activates ERK signaling in response to S1P and fibronectin	
CDK9	EC 2.7.11.22; EC 2.7.11.23; KINASE; Kinase, protein; Nuclear receptor co-regulator; Protein kinase, CMGC; Protein kinase, Ser/Thr (non-receptor)	P50750	1025	CDK9	9q34.1	human	S347	PHOSPHORYLATION	3681502	APPRRKGsQITQQST		molecular association, regulation			RNA(INDUCES)	25779401	2	11	68	HIV-1 TAR RNA	
HDGF	Cytokine; Transcription regulation	P51859	15191	Hdgf		mouse	S165	PHOSPHORYLATION	452720	AGDVLEDsPKRPKES		protein processing; intracellular localization				17675059	2	67	25	positively regulates HDGF secretion by inhibiting its N-terminal truncation	
PELI1	Adaptor/scaffold; EC 6.3.2.-; EC 6.3.2.19; Ligase; UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase	Q96FA3	57162	PELI1	2p13.3	human	S76	PHOSPHORYLATION	7388015	ISNKDQHsISYTLSR	Pellino	ubiquitination; enzymatic activity, induced				7228504	2	1	2		
TP2	DNA binding protein	P11101	24840	Tnp2		rat	T101	PHOSPHORYLATION	450901	AVRRRKRtHRAKRRS	TP2; YL1; MoCo_carrier	intracellular localization				3047	1	0	0		
MEF2C	DNA binding protein; Transcription factor	Q06413	4208	MEF2C	5q14.3	human	S396	PHOSPHORYLATION	456980	NIKSEPVsPPRDRTT		sumoylation; protein processing	transcription, induced			7570; 7645	3	4	0		
HSL	EC 3.1.1.79; Lipase	Q05469	3991	LIPE	19q13.2	human	S950	PHOSPHORYLATION	450194	EGFHPRRsSQGATQM	Abhydrolase_3	molecular association, regulation; enzymatic activity, induced		FABP4(INDUCES)		3361004; 6702314	6	2	0		
GATA4	Motility/polarity/chemotaxis; Transcription factor	Q08369	14463	Gata4		mouse	S105	PHOSPHORYLATION	449604	AYTPPPVsPRFSFPG	GATA-N	activity, induced	transcription, induced			2246	12	0	0		
JunB	Motility/polarity/chemotaxis; Transcription factor	P24898	24517	Junb		rat	S186	PHOSPHORYLATION	1814003	YTNLSSYsPASAPSG	Jun	protein degradation	cell cycle regulation; transcription, altered			1813900	1	0	0	Phosphorylation promoted degradation during the G2-M transition.  JunB inhibition of cyclin D1 transcription is relieved by JunB protein degradation.	
PML iso4	Transcription factor; Tumor suppressor; Ubiquitin conjugating system	P29590-4	5371	PML	15q22	human	S40	PHOSPHORYLATION	451471	RQPSPSPsPTERAPA		protein stabilization	apoptosis, altered			3657	1	3	0	Phosphorylation of PML is associated with enhanced sumoylation and apoptosis induced by As2O3. 	
PPP1R2	Inhibitor protein; Motility/polarity/chemotaxis; Protein phosphatase, regulatory subunit	P41236	5504	PPP1R2	3q29	human	T73	PHOSPHORYLATION	449051	MKIDEPStPYHSMMG	IPP-2	intracellular localization; protein conformation; enzymatic activity, induced				3958; 26349409	9	4	1		
PAR3-alpha	Adaptor/scaffold; Motility/polarity/chemotaxis	Q8TEW0	56288	PARD3	10p11.21	human	S144	PHOSPHORYLATION	455668	PLHVRRSsDPALIGL	DUF3534	molecular association, regulation	cytoskeletal reorganization	14-3-3 zeta(INDUCES); Gab1(DISRUPTS)		5710; 25712645	3	12	26		
CACNA1C iso4	Channel, calcium; Membrane protein, integral; Membrane protein, multi-pass	P15381-4		CACNA1C		rabbit	S1570	PHOSPHORYLATION	467228	VACKRLVsMNMPLNS		activity, induced				8157	2	0	0		
TSC2	Cell cycle regulation; GTPase activating protein, misc.; Nuclear receptor co-regulator; Tumor suppressor	P49815	7249	TSC2	16p13.3	human	S1254	PHOSPHORYLATION	448807	TALYKSLsVPAASTA		molecular association, regulation		14-3-3 beta(INDUCES)		5844	4	8	14		
Myt1	EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, Other; Protein kinase, dual-specificity	Q95YJ1		Pkmyt1		starfish	S75	PHOSPHORYLATION	449752	ESRPRAVsFRQSEPS		activity, inhibited	cell cycle regulation			2344	1	0	0		
TREK-1	Channel, potassium; Membrane protein, integral; Membrane protein, multi-pass	O95069	3776	KCNK2	1q41	human	S348	PHOSPHORYLATION	456161	KETRRRLsVEIYDKF		activity, inhibited				9689413; 25573560	7	3	0	current reduced by phosphorylation; lidocaine- treated cells	
Met	EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Protein kinase, TK; Protein kinase, tyrosine (receptor)	P16056	17295	Met		mouse	Y1232	PHOSPHORYLATION	448470	RDMYDKEyYSVHNKT	Pkinase_Tyr	ubiquitination; enzymatic activity, induced				4961500; 9721216; 2849	35	21	702		
ITGB2	Cell adhesion; Cell surface; Membrane protein, integral; Motility/polarity/chemotaxis; Receptor, misc.	P11835	16414	Itgb2		mouse	T762	PHOSPHORYLATION	450185	LFKSATTtVMNPKFA			cell motility, induced; cell adhesion, induced			28722117	3	0	0	T-cell homing to lymphocytes	
STMN2	Cytoskeletal protein	P21818	84510	Stmn2		rat	S50	PHOSPHORYLATION	455606	KQINKRAsGQAFELI	Stathmin	molecular association, regulation	cytoskeletal reorganization	TUBA1A(INDUCES); TUBB(INDUCES)		5546; 5533	3	4	0		
SNAPIN	Vesicle protein	O95295	23557	SNAPIN	1q21.3	human	T117	PHOSPHORYLATION	28761202	NHSVAKEtARRRAML	IncA; Spc7; Laminin_II; Flagellar_rod	molecular association, regulation	exocytosis, inhibited	SNAP-25(DISRUPTS)		28761501	1	0	0		
BAD	Apoptosis	Q61337	12015	Bad		mouse	S136	PHOSPHORYLATION	447862	PFRGRSRsAPPNLWA	Bcl-2_BAD; Bclx_interact	activity, induced; molecular association, regulation; intracellular localization; activity, inhibited; phosphorylation	apoptosis, altered; apoptosis, inhibited; cell growth, altered	Bcl-xL(NOT_REPORTED); JNK1(DISRUPTS); 14-3-3 zeta(INDUCES); PKACA(INDUCES); 14-3-3 beta(NOT_REPORTED); PPP2CA(INDUCES); 14-3-3 beta(INDUCES); 14-3-3 theta(INDUCES); Bcl-2(DISRUPTS); PKCA(INDUCES); Bcl-xL(DISRUPTS)		2347; 6470; 7550829; 6594; 5376; 6597; 1903007; 6455; 7098; 5325; 465; 4646618; 25255521; 6759; 17482901; 5293; 4646619; 4478; 4646620; 2267; 4646626	112	26	189		
TrkB	EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Protein kinase, TK; Protein kinase, tyrosine (receptor)	Q63604	25054	Ntrk2		rat	Y515	PHOSPHORYLATION	448813	PVIENPQyFGITNSQ		molecular association, regulation; phosphorylation; enzymatic activity, induced	translation, altered	Shc1(INDUCES); Shc2(INDUCES); Shc3(INDUCES)		5432; 1969110; 7398; 4028; 10199100; 4620	20	2	40	c-fos protein synthesis induced by BDNF	
eIF2-alpha	Translation; Translation initiation	Q6ZWX6	13665	Eif2s1		mouse	S52	PHOSPHORYLATION	447635	MILLSELsRRRIRSI	S1	activity, induced; activity, inhibited	translation, altered; apoptosis, inhibited; transcription, induced; translation, inhibited; cell growth, altered			30281302; 15331035; 4861501; 15031319; 4520; 7124715; 18378500; 2701905; 5263; 3404211	61	2	0		
p53	Activator protein; DNA binding protein; Motility/polarity/chemotaxis; Nuclear receptor co-regulator; Transcription factor; Tumor suppressor	P02340	22059	Tp53		mouse	K366	UBIQUITINATION	464660	HSSYLKTkKGQSTSR			transcription, altered			3141407	11	0	0	p53K6R (K378/383/369/379/367/370/R) mutant is still ubiquitinated and shows normal stability of p53 before and after DNA damage	
RPS5	Ribosomal protein; Translation	P97461	20103	Rps5		mouse	S24	PHOSPHORYLATION	9819906	IKLFGKWsTDDVQIN		intracellular localization				9721212	1	0	0		
rabphilin 3A	Vesicle protein	P47708	19894	Rph3a		mouse	S234	PHOSPHORYLATION	455904	GPPTRRAsEARMSTA		intracellular localization				6424	4	0	2		
GYS1	Carbohydrate Metabolism - starch and sucrose; EC 2.4.1.11; Transferase	P13807	2997	GYS1	19q13.3	human	S645	PHOSPHORYLATION	448238	RPASVPPsPSLSRHS	Glycogen_syn	enzymatic activity, inhibited				7543506	20	13	7		
TSPY1	Cancer Testis Antigen (CTA)	Q01534	7258	TSPY1	Yp11.2	human	T300	PHOSPHORYLATION	460704	PPEEGTEtSGDSQLL		protein stabilization; intracellular localization				7766	1	0	0	important for the nuclear transport	
ILK	EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, Ser/Thr (non-receptor); Protein kinase, TKL	Q13418	3611	ILK	11p15.4	human	T173	PHOSPHORYLATION	479406	DTFWKGTtRTRPRNG		intracellular localization	cell motility, altered			9405	2	1	1		
NFAT2	DNA binding protein; Transcription factor	O95644	4772	NFATC1	18q23	human	S294	PHOSPHORYLATION	448863	PHGSPRVsVTDDSWL		intracellular localization; activity, inhibited				2031	1	0	0		
SP1	C2H2-type zinc finger protein; DNA binding protein; Transcription factor	P08047	6667	SP1	12q13.1	human	S641	PHOSPHORYLATION	470040	GKVYGKTsHLRAHLR		activity, induced; molecular association, regulation	transcription, induced; transcription, altered	Rb-like 1(DISRUPTS)		8942; 7910505	3	1	0		
CACNA1C iso12	Channel, calcium; Membrane protein, integral; Membrane protein, multi-pass	Q13936-12		CACNA1C	12p13.3	human	Y2134	PHOSPHORYLATION	1043301	ELQDSRVyVSSL___			signaling pathway regulation			12558728	2	0	0	mutation (Y to F) prevents depolarization-induced CRE activation	
STAT2	DNA binding protein; Transcription factor	P52630	6773	STAT2	12q13.3	human	Y631	PHOSPHORYLATION	479848	LIYSVQPyTKEVLQS	SH2		apoptosis, inhibited			11495	1	0	0	STAT2 Y631F mutant promotes IFN-alpha-induced apoptosis	
BubR1	EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor)	O60566	701	BUB1B	15q15	human	S676	PHOSPHORYLATION	767909	LSPIIEDsREATHSS		molecular association, regulation	cell cycle regulation; cytoskeletal reorganization	PPP2R5A(INDUCES); PPP2CA(INDUCES)		762713; 27519650; 27132456; 13159707	4	1	0	 T680 is independent of attachment status and may correlate with lack of interkinetochore tension.; regulates chromosome congression; kinetochore-microtubule stability and lack of tension ; chromosome segregation during mitosis and mitotic progression; kinetochore-microtubule attachment	
HIF1A	Autophagy; DNA binding protein; Transcription factor	Q16665	3091	HIF1A	14q23.2	human	S576	PHOSPHORYLATION	17331801	DDDFQLRsFDQLSPL	HIF-1	protein degradation				17299800	1	1	0		
GATA1	DNA binding protein; Transcription factor	P15976	2623	GATA1	Xp11.23	human	S310	PHOSPHORYLATION	451231	QTRNRKAsGKGKKKR			transcription, induced			6848	7	0	0		
MAP2	Cytoskeletal protein; Motility/polarity/chemotaxis	P11137	4133	MAP2	2q34-q35	human	Y67	PHOSPHORYLATION	454429	EHGSQGTySNTKENG		molecular association, regulation		Grb2(INDUCES)		4303	2	0	0		
PDE4B iso2	EC 3.1.4.17; Nucleotide Metabolism - purine; Phosphodiesterase	Q07343-2	5142	PDE4B	1p31	human	S488	PHOSPHORYLATION	471380	YQSMIPQsPSPPLDE		enzymatic activity, induced				9133	1	4	0	decreases levels of cAMP	
FOXO4	DNA binding protein; Transcription factor	P98177	4303	FOXO4	Xq13.1	human	S230	PHOSPHORYLATION	471960	PEGATPTsPVGHFAK			carcinogenesis, altered; transcription, altered			15785208	1	5	6		
TAO2 iso2	Apoptosis; EC 2.7.11.1; KINASE; Kinase, protein; Membrane protein, integral; Membrane protein, multi-pass; Protein kinase, STE; Protein kinase, Ser/Thr (non-receptor)	Q9JLS3-2	64666	tao2 beta		rat	S1038	PHOSPHORYLATION	1308925	AAVPGPLsRSTSVAS		intracellular localization	endocytosis, altered			1172825	1	0	0		
ATRIP	Cell cycle regulation; DNA binding protein; DNA repair	Q8WXE1	84126	ATRIP	3p21.31	human	S72	PHOSPHORYLATION	454389	TLASQALsQCPAAAR	IncA	intracellular localization				4265	1	0	0		
RhoGDI alpha	Apoptosis; Cell adhesion; Cell development/differentiation; G protein regulator, misc.; Motility/polarity/chemotaxis	Q99PT1	192662	Arhgdia		mouse	S96	PHOSPHORYLATION	486318	DLTGDLEsFKKQSFV	Rho_GDI	activity, induced; molecular association, regulation		RhoG(DISRUPTS); GIPC1(DISRUPTS)		9721225	3	0	0	ternary complex with syndecan 4	
MEK1	EC 2.7.12.2; KINASE; Kinase, protein; Protein kinase, STE; Protein kinase, dual-specificity	Q02750	5604	MAP2K1	15q22.1-q22.33	human	T386	PHOSPHORYLATION	448288	IGLNQPStPTHAAGV		molecular association, regulation; intracellular localization		ERK2(INDUCES)		6841100; 1165	4	4	54	nuclear translocation	
NDR2	EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor)	Q9Y2H1	23012	STK38L	12p11.23	human	S282	PHOSPHORYLATION	460298	NRRQLAYsTVGTPDY	Pkinase	enzymatic activity, induced	cell growth, altered			7692; 3334; 7365	4	1	6		
hnRNP K	RNA binding protein; RNA splicing; Spliceosome	P61978	3190	HNRNPK	9q21.32-q21.33	human	Y72	PHOSPHORYLATION	455999	IKALRTDyNASVSVP	KH_1		translation, altered			6566	2	4	0	based on Y72/225/230/234/236/380A mutant	
CCKBR	GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR	P32239	887	CCKBR	11p15.4	human	S434	PHOSPHORYLATION	6057803	TPSIASLsRLSYTTI		molecular association, regulation		RGS2(INDUCES)		5930020	1	1	0		
FAK iso3	EC 2.7.1.112; EC 2.7.10.2; KINASE; Kinase, protein; Protein kinase, TK; Protein kinase, tyrosine (non-receptor)	P34152-3	14083	Ptk2		mouse	Y861	PHOSPHORYLATION	447965	PTGNQHIyQPVGKPD		phosphorylation	cytoskeletal reorganization			2705202	59	12	286	Y861 phosphorylation is necessary for cell survival after osmotic stress. 	
SQSTM1	Autophagy; Nuclear receptor co-regulator; Ubiquitin conjugating system	Q13501	8878	SQSTM1	5q35	human	S272	PHOSPHORYLATION	454787	RSRLTPVsPESSSTE		protein degradation; ubiquitination	cell cycle regulation; carcinogenesis, altered			17431509	2	36	244	protects cyclin B1 from ubiquitylation and degradation	
Huntingtin	Cytoskeletal protein	P42858	3064	HTT	4p16.3	human	T3	PHOSPHORYLATION	10206804	_____MAtLEKLMKA		molecular association, regulation		Huntingtin(INDUCES)		9980408	2	1	0	enhances huntingtin aggregation and neurodegeneration in transgenic flies	
CSFR	EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Protein kinase, TK; Protein kinase, tyrosine (receptor)	P09581	12978	Csf1r		mouse	Y921	PHOSPHORYLATION	455145	LERRDQDyANLPSSG		molecular association, regulation	cytoskeletal reorganization; cell growth, altered	Grb2(INDUCES)		3955	3	1	1	 	
CK1E	EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, CK1; Protein kinase, Ser/Thr (non-receptor)	P49674	1454	CSNK1E	22q13.1	human	T44	PHOSPHORYLATION	14694702	IKLECVKtKHPQLHI	Pkinase	enzymatic activity, induced				14551410	1	0	0		
CERK	EC 2.7.1.138; Kinase, lipid; Lipid Metabolism - sphingolipid	Q8TCT0	64781	CERK	22q13.31	human	S340	PHOSPHORYLATION	11485302	PAQHTVGsPRDRKPC		protein stabilization				11419331	1	1	0		
FAM125A	Adaptor/scaffold	Q96EY5	93343	FAM125A	19p13.11	human	S232	PHOSPHORYLATION	483399	RFEGKSCsPLAFSAF	DUF2464	protein processing				12660601	1	2	0	inhibition of HIV-1 release and infectivity	
ADD1	Cytoskeletal protein; Motility/polarity/chemotaxis	P35611	118	ADD1	4p16.3	human	S716	PHOSPHORYLATION	449828	GSPGKSPsKKKKKFR		intracellular localization	cytoskeletal reorganization			2346	4	0	0		
CREB	DNA binding protein; Transcription factor	P16220	1385	CREB1	2q34	human	S108	PHOSPHORYLATION	451807	QISTIAEsEDSQESV		molecular association, regulation; phosphorylation		CBP(INDUCES)		9565	7	0	1	mutation to alanine decreases S121 phosphorylation in cells treated with ionizing radiation	
SLP76	Adaptor/scaffold	Q13094	3937	LCP2	5q35.1	human	Y113	PHOSPHORYLATION	448218	SSFEEDDyESPNDDQ		molecular association, regulation; phosphorylation	cytoskeletal reorganization; transcription, induced	ITK(INDUCES); Nck1(INDUCES); VAV1(INDUCES); PIK3R1(INDUCES)		5955628; 25725911; 2630609; 2943; 4730	15	0	0		
GRK2	EC 2.7.11.15; KINASE; Kinase, protein; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor)	P21146	282682	ADRBK1		cow	Y13	PHOSPHORYLATION	456872	AVLADVSyLMAMEKS		enzymatic activity, induced				2831776	5	0	0		
ER-alpha	DNA binding protein; Nuclear receptor	P03372	2099	ESR1	6q25.1	human	S305	PHOSPHORYLATION	448805	IKRSKKNsLALSLTA		activity, induced; molecular association, regulation; intracellular localization; protein conformation; phosphorylation	carcinogenesis, altered; transcription, induced; transcription, altered; cell growth, altered	NRIF3(INDUCES)		1926900; 2831765; 1159500; 9033; 1967; 13270501; 13852002	13	0	0	Nuclear S305 phosphorylation and PAK1 nuclear localization was correlated in PAK1 positive tumors. Nuclear S305 phosphorylation correlated with small  and ER positive tumors, which had reduced response to tamoxifen therapy.; in K303R mutant	
PXR	DNA binding protein; Nuclear receptor	O75469	8856	NR1I2	3q12-q13.3	human	S8	PHOSPHORYLATION	9730705	MEVRPKEsWNHADFV		molecular association, regulation	transcription, altered	RXRA(DISRUPTS)		9689411	1	0	0	inhibits transcription	
EGFR	EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Protein kinase, TK; Protein kinase, tyrosine (receptor)	P00533	1956	EGFR	7p12	human	S991	PHOSPHORYLATION	455701	DERMHLPsPTDSNFY		molecular association, regulation; receptor internalization, altered; phosphorylation		Cbl(INDUCES); ubiquitin(INDUCES)		9158108	2	18	5		
TSC2	Cell cycle regulation; GTPase activating protein, misc.; Nuclear receptor co-regulator; Tumor suppressor	P49816	24855	Tsc2		rat	Y1573	PHOSPHORYLATION	448502	NEHGSYRyTEFLTGL	Rap_GAP	activity, induced; molecular association, regulation	cell growth, altered	TSC1(INDUCES)		820	2	0	1		
TGFBR1	EC 2.7.11.30; KINASE; Kinase, protein; Membrane protein, integral; Protein kinase, Ser/Thr (receptor); Protein kinase, TKL; Receptor, misc.	P36897	7046	TGFBR1	9q22	human	S172	PHOSPHORYLATION	4331006	SLDRPFIsEGTTLKD			cell growth, altered			4332501	1	0	0		
DDR1	EC 2.7.1.112; EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Protein kinase, TK; Protein kinase, tyrosine (receptor)	Q08345	780	DDR1	6p21.3	human	Y740	PHOSPHORYLATION	458377	AQGPTISyPMLLHVA	Pkinase_Tyr	molecular association, regulation		Nck2(INDUCES); SHP-2(INDUCES)		7399	1	0	0		
NCAPG	Cell cycle regulation	Q9BPX3	64151	NCAPG	4p15.33	human	T332	PHOSPHORYLATION	5014904	LIPVETLtPEIALYW		molecular association, regulation; intracellular localization			DNA(INDUCES)	5014017	1	0	0	regulates NCAPG localization with chromosomal DNA in mitotic cells	
InsR iso2	EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Protein kinase, TK; Protein kinase, tyrosine (receptor)	P06213-2	3643	INSR	19p13.3-p13.2	human	S989	PHOSPHORYLATION	449888	SSNPEYLsASDVFPC		activity, induced				1123	1	0	0	mutation of site impairs insulin stimulation of PI3K activity.	
FGFR1	EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Protein kinase, TK; Protein kinase, tyrosine (receptor)	P11362	2260	FGFR1	8p12	human	Y677	PHOSPHORYLATION	447920	EALFDRIyTHQSDVW	Pkinase_Tyr	molecular association, regulation		STAT3(INDUCES)		14654312	2	0	0		
PAR1	Cell development/differentiation; GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR	P25116	2149	F2R	5q13	human	S391	PHOSPHORYLATION	3627501	SILCCKEsSDPSSYN		receptor desensitization, altered				4656	1	0	0	receptor shutoff (not internalization)	
hnRNP K	RNA binding protein; RNA splicing; Spliceosome	P61978	3190	HNRNPK	9q21.32-q21.33	human	S216	PHOSPHORYLATION	450148	ILDLISEsPIKGRAQ	Phi-29_GP3	activity, induced	transcription, altered			1120	3	33	4		
SLC14A2	Membrane protein, integral; Membrane protein, multi-pass; Transporter	NP_062220	54302	Slc14a2		rat	S499	PHOSPHORYLATION	2813500	WSSIRRRsKVFGKSE		activity, induced; molecular association, regulation; intracellular localization		SNAPIN(INDUCES)		2807221; 14058632	4	0	0		
GRK2	EC 2.7.11.15; KINASE; Kinase, protein; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor)	Q99MK8	110355	Adrbk1		mouse	Y92	PHOSPHORYLATION	456873	FYEEIKKyEKLETEE	RGS		cell motility, altered			2425208	5	0	0		
Pyk2	EC 2.7.10.2; KINASE; Kinase, protein; Nuclear receptor co-regulator; Protein kinase, TK; Protein kinase, tyrosine (non-receptor)	Q14289	2185	PTK2B	8p21.1	human	Y881	PHOSPHORYLATION	447958	DRTDDLVyLNVMELV	Focal_AT	molecular association, regulation		Grb2(INDUCES)		27902352	17	0	1	Grb2 recruitment to SHPS1	
ZAK	EC 2.7.11.25; KINASE; Kinase, protein; Protein kinase, Ser/Thr (non-receptor); Protein kinase, TKL	Q9NYL2	51776	ZAK	2q24.2	human	T161	PHOSPHORYLATION	455377	ASRFHNHtTHMSLVG	Pkinase_Tyr	enzymatic activity, induced				4622	1	0	0		
SCN10A	Channel, sodium; Membrane protein, integral; Membrane protein, multi-pass	Q62968		Scn10a		rat	S551	PHOSPHORYLATION	2482300	QTGPLPRsPLPQSPN		activity, induced				2451813	1	0	0	increases SCN10A sodium channel current density  	
RXRA	DNA binding protein; Motility/polarity/chemotaxis; Nuclear receptor	P19793	6256	RXRA	9q34.3	human	S27	PHOSPHORYLATION	3188103	TSPTGRGsMAAPSLH	Nuc_recep-AF1	activity, inhibited	transcription, altered			8790	1	0	0		
HOXA9	DNA binding protein	P09631	15405	Hoxa9		mouse	S204	PHOSPHORYLATION	2906100	ANWLHARsTRKKRCP		molecular association, regulation	cell differentiation, altered		DNA(DISRUPTS)	8557	1	0	0		
FOXO1A	DNA binding protein; Nuclear receptor co-regulator; Transcription factor	Q12778	2308	FOXO1	13q14.1	human	K294	ACETYLATION	15625100	SPGSQFSkWPASPGS		intracellular localization; phosphorylation				15022750	1	0	0		
GABRG2	Channel, chloride; Channel, ligand-gated; Membrane protein, integral; Membrane protein, multi-pass	Q6PW52	29709	Gabrg2		rat	Y413	PHOSPHORYLATION	455818	ERDEEYGyECLDGKD	Neur_chan_memb	molecular association, regulation		Src(INDUCES)		6319	7	0	0		
VDR	DNA binding protein; Nuclear receptor; Transcription factor	P11473	7421	VDR	12q13.11	human	S208	PHOSPHORYLATION	456982	SFSNLDLsEEDSDDP	Hormone_recep	molecular association, regulation	transcription, induced; transcription, altered	MED1(INDUCES)		4663; 9607	3	0	0		
NHE1	Membrane protein, integral; Membrane protein, multi-pass; Motility/polarity/chemotaxis; Transporter	P26431	24782	Slc9a1		rat	S652	PHOSPHORYLATION	3880766	KTRQRLRsYNRHTLV		activity, induced	cytoskeletal reorganization; cell growth, altered			9938509	3	1	6		
p21Cip1	Cell cycle regulation; Inhibitor protein	P38936	1026	CDKN1A	6p21.2	human	T57	PHOSPHORYLATION	451222	NFDFVTEtPLEGDFA	CDI	protein degradation; protein stabilization; ubiquitination; intracellular localization	cell cycle regulation			3458; 12021313; 7601400	6	0	0		
Cdc25A	EC 3.1.3.48; Motility/polarity/chemotaxis; PHOSPHATASE; Protein phosphatase, dual-specificity	P30304	993	CDC25A	3p21	human	S293	PHOSPHORYLATION	449128	GSTKRRKsMSGASPK	M-inducer_phosp	protein degradation				2163	2	0	0		
IkB-alpha	DNA binding protein; Inhibitor protein	P25963	4792	NFKBIA	14q13	human	T299	PHOSPHORYLATION	456335	ESEFTEFtEDELPYD		protein degradation				12482204	2	0	0	S283/T291/T299A  triple mutant showed increased IkB-alpha stability.	
CFTR	Channel, chloride; EC 3.6.3.49; Hydrolase; Membrane protein, integral; Membrane protein, multi-pass; Transporter	P13569	1080	CFTR	7q31.2	human	S813	PHOSPHORYLATION	449983	DIYSRRLsQETGLEI	CFTR_R	activity, induced; molecular association, regulation; enzymatic activity, inhibited; protein conformation		CFTR(INDUCES)		4474; 8370; 2537	7	1	0	S660A and S813A mutations alone significantly decreased current compared to wild-type. 	
TIF1A	Transcription initiation complex	Q9NYV6	54700	RRN3	16p12	human	S172	PHOSPHORYLATION	470002	GDVDVSDsDDEDDNL	RRN3	activity, induced; molecular association, regulation	cell cycle regulation; chromatin organization, altered; transcription, induced	TWISTNB(DISRUPTS)		2831756	1	11	2		
GR	DNA binding protein; Mitochondrial; Nuclear receptor; Transcription factor	P06537	14815	Nr3c1		mouse	S234	PHOSPHORYLATION	451796	LIDENLLsPLAGEDD	GCR		transcription, induced			21683716	23	4	1		
CDK1	EC 2.7.11.22; EC 2.7.11.23; KINASE; Kinase, protein; Motility/polarity/chemotaxis; Protein kinase, CMGC; Protein kinase, Ser/Thr (non-receptor)	P06493	983	CDK1	10q21.1	human	S39	PHOSPHORYLATION	455465	MKKIRLEsEEEGVPS	Pkinase		cell cycle regulation			5241	2	4	14		
TTK	Cancer Testis Antigen (CTA); EC 2.7.12.1; KINASE; Kinase, protein; Protein kinase, Other; Protein kinase, dual-specificity	P33981	7272	TTK	6q13-q21	human	S15	PHOSPHORYLATION	13194900	GRELTIDsIMNKVRD		intracellular localization				13164217	2	1	2	regulates kinetochore localization of TTK	
eIF2-alpha	Translation; Translation initiation	P05198	1965	EIF2S1	14q23.3	human	S52	PHOSPHORYLATION	447635	MILLSELsRRRIRSI	S1	activity, induced; molecular association, regulation; activity, inhibited	translation, altered; apoptosis, induced; apoptosis, inhibited; cell growth, altered	eIF2-beta(INDUCES); PERK(INDUCES)		4861502; 15331035; 662; 2455800; 6542; 7290; 1163004; 1172838; 2665400	61	2	0	in response to glucose deficiency	
VAV1	Guanine nucleotide exchange factor, Rac/Rho; Motility/polarity/chemotaxis	P27870	22324	Vav1		mouse	Y174	PHOSPHORYLATION	447866	EAEGDEIyEDLMRLE		activity, induced; activity, inhibited	cytoskeletal reorganization; transcription, altered; cell growth, altered			13354739; 1976	12	0	0		
Rb	Nuclear receptor co-regulator; Transcription, coactivator/corepressor; Tumor suppressor	P13405	19645	Rb1		mouse	S800	PHOSPHORYLATION	447980	PGGNIYIsPLKSPYK	Rb_C	molecular association, regulation; protein conformation		E2F1(DISRUPTS)		4073; 1258	48	22	110		
FMIP	Cell development/differentiation; RNA splicing; Spliceosome	Q13769	8563	THOC5	22q12.2	human	S6	PHOSPHORYLATION	453433	__MSSESsKKRKPKV		intracellular localization				4145	1	0	0		
Notch 1	Membrane protein, integral; Motility/polarity/chemotaxis; Receptor, misc.; Transcription factor	Q01705	18128	Notch1		mouse	K2147	ACETYLATION	18899504	KSATQGKkARKPSTK		protein stabilization; ubiquitination				18899000	1	1	0		
ITCH	EC 6.3.2.-; EC 6.3.2.19; Ligase; UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase	Q8C863	16396	Itch		mouse	S232	PHOSPHORYLATION	459623	RPASVNGsPSTNSDS		activity, induced; protein stabilization; protein conformation				7638	1	0	0		
KSR	KINASE; Kinase, protein; Protein kinase, Ser/Thr (non-receptor); Protein kinase, TKL	Q61097	16706	Ksr1		mouse	S392	PHOSPHORYLATION	449297	ARLRRTEsVPSDINN		protein degradation; molecular association, regulation; intracellular localization	cell cycle regulation; cell growth, altered	14-3-3 beta(INDUCES)		4282; 5350; 6456; 2168; 2169	5	22	53		
PERK	EC 2.7.11.1; KINASE; Kinase, protein; Membrane protein, integral; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor); Translation	Q9Z2B5	13666	Eif2ak3		mouse	Y615	PHOSPHORYLATION	1256400	NKVDDCNyAIKRIRL	Pkinase	enzymatic activity, induced	translation, altered			1172838	3	0	0	regulates translation through the phosphorylation of eIF2A at S51	
TORC2	Transcription, coactivator/corepressor	Q8BH09	74343	Crtc2		mouse	S307	PHOSPHORYLATION	454633	PSLSGGNsTTNLTHT	TORC_M	intracellular localization				14784602	1	1	0		
HMGB1	DNA repair; Nuclear receptor co-regulator	P09429	3146	HMGB1	13q12	human	S42	PHOSPHORYLATION	9484300	SVNFSEFsKKCSERW	Nop14; DUF1898; Nucleo_P87	intracellular localization	cell motility, altered			9201014	2	1	2	increases tumor cell invasiveness	
NFkB-p65	DNA binding protein; Nuclear receptor co-regulator; Transcription factor	Q04206	5970	RELA	11q13	human	K195	UBIQUITINATION	10304900	APNTAELkICRVNRN		protein degradation; activity, inhibited	transcription, altered			9980450	2	0	0	TNF alpha - induced RelA polyubiquitination and degradation	
GluR6	Channel, calcium; Channel, ligand-gated; Membrane protein, integral; Membrane protein, multi-pass	P42260	54257	Grik2		rat	S868	PHOSPHORYLATION	478417	MVEELRMsLKCQRRL		sumoylation; molecular association, regulation	endocytosis, induced	14-3-3 theta(INDUCES)		28722149; 22463930	5	0	0	increases sumoylation	
GR	DNA binding protein; Mitochondrial; Nuclear receptor; Transcription factor	P04150	2908	NR3C1	5q31.3	human	S211	PHOSPHORYLATION	447968	PGKETNEsPWRSDLL	GCR	protein stabilization; molecular association, regulation; protein conformation; activity, inhibited	apoptosis, induced; transcription, induced; transcription, altered; transcription, inhibited	GRIP1(INDUCES)		6130; 13298802; 12080; 13159409	27	1	0		
p53	Activator protein; DNA binding protein; Motility/polarity/chemotaxis; Nuclear receptor co-regulator; Transcription factor; Tumor suppressor	P04637	7157	TP53	17p13.1	human	K139	UBIQUITINATION	486295	KMFCQLAkTCPVQLW	P53	protein degradation; intracellular localization				12136	1	0	0		
MC4R	GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR	P32245	4160	MC4R	18q22	human	T312	PHOSPHORYLATION	449101	RSQELRKtFKEIICC		receptor internalization, altered				2136	2	0	0		
TORC2	Transcription, coactivator/corepressor	Q8BH09	74343	Crtc2		mouse	S171	O-GlcNAc	10902816	SALNRTSsDSALHTS	TORC_M	activity, induced; molecular association, regulation; intracellular localization; phosphorylation		14-3-3 beta(DISRUPTS)		6337804	1	1	0	inhibits phosphorylation of its own site	
APLP2	Cell surface; DNA binding protein; Membrane protein, integral; Receptor, misc.	Q06481	334	APLP2	11q24	human	T736	PHOSPHORYLATION	451599	VEVDPMLtPEERHLN	APP_amyloid	molecular association, regulation		APBA2(INDUCES); Fe65(INDUCES)		2816; 3733	3	2	0	Phosphorylation of APP and APLP2 was enhanced by osmotic stress, binding to ABPA2, and JNK (in vitro).	
Fli1	DNA binding protein; Transcription factor	Q01543	2313	FLI1	11q24.1-q24.3	human	T312	PHOSPHORYLATION	6406002	TNGEFKMtDPDEVAR	Ets	protein degradation; molecular association, regulation; acetylation	transcription, induced; transcription, altered		DNA(INDUCES)	18415122; 6331317	4	0	0		
Met	EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Protein kinase, TK; Protein kinase, tyrosine (receptor)	P08581	4233	MET	7q31	human	S985	PHOSPHORYLATION	450188	PHLDRLVsARSVSPT		intracellular localization; enzymatic activity, inhibited				2848; 27902305	5	0	0	increased intracellular localization, and decreased cell membrane localization   ; in vitro	
TrkB	EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Protein kinase, TK; Protein kinase, tyrosine (receptor)	P15209	18212	Ntrk2		mouse	Y515	PHOSPHORYLATION	448813	PVIENPQyFGITNSQ		receptor internalization, altered; phosphorylation; enzymatic activity, induced	cell growth, altered			2656; 3503	20	2	40		
InsR	EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Protein kinase, TK; Protein kinase, tyrosine (receptor)	P06213	3643	INSR	19p13.3-p13.2	human	Y1190	PHOSPHORYLATION	447682	DIYETDYyRKGGKGL	Pkinase_Tyr	molecular association, regulation; receptor internalization, altered; phosphorylation; enzymatic activity, induced	transcription, altered	IRS2(INDUCES); PTP1B(INDUCES)		2852622; 9082; 8575; 3694; 2178; 8589	34	10	108	prolactin transcription	
CASK	Adaptor/scaffold; EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, CAMK; Protein kinase, Ser/Thr (non-receptor)	Q62915	29647	Cask		rat	T724	PHOSPHORYLATION	12568401	LPAFKRKtLVLLGAH	Guanylate_kin	molecular association, regulation	transcription, altered	Tbr1(INDUCES)		12558737	1	0	2	CASK-Tbr1 complex regulates expression of NMDAR2b	
AR	DNA binding protein; Nuclear receptor; Transcription factor	P10275	367	AR	Xq12	human	S515	PHOSPHORYLATION	452166	VSRVPYPsPTCVKSE		protein degradation; ubiquitination	transcription, induced; transcription, altered			4264907; 17675023	4	1	0		
PKN2	EC 2.7.11.13; KINASE; Kinase, protein; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor)	Q16513	5586	PKN2	1p22.2	human	T816	PHOSPHORYLATION	447838	GYGDRTStFCGTPEF	Pkinase	enzymatic activity, induced				765; 10353916	3	7	280		
GIRK4	Channel, potassium; Membrane protein, integral; Membrane protein, multi-pass	P48548	29713	Kcnj5		rat	Y53	PHOSPHORYLATION	3146603	GKKPRQRyMEKTGKC		activity, inhibited				8596	1	0	0		
HMOX1	Cofactor and Vitamin Metabolism - porphyrin and chlorophyll; EC 1.14.99.3; Oxidoreductase	P09601	3162	HMOX1	22q13.1	human	S188	PHOSPHORYLATION	2897404	LYRSRMNsLEMTPAV	Heme_oxygenase	molecular association, regulation; enzymatic activity, induced		BVR(INDUCES); POR(INDUCES)		8556	1	0	3		
NUP98 iso2	Motility/polarity/chemotaxis; Nucleoporin	P52948-2	4928	NUP98	11p15.5	human	S822	PHOSPHORYLATION	3150833	TSRCLIKsPDRLADI	Nucleoporin2	intracellular localization				18331300	1	15	17	as multiple sites (13PM) mutant 	
EXOC7	Cytoskeletal protein	Q9UPT5	23265	EXOC7	17q25.1	human	S250	PHOSPHORYLATION	483909	SSSGVPYsPAIPNKR		molecular association, regulation	exocytosis, induced; cell motility, induced; cytoskeletal reorganization	EXOC4(INDUCES); EXOC8(INDUCES)		25347039	1	8	6		
FLRT1	Cell adhesion; Membrane protein, integral; Motility/polarity/chemotaxis	Q9NZU1	23769	FLRT1	11q12-q13	human	Y643	ACETYLATION	14150101	GGIPDIDySYT____		intracellular localization	cell growth, altered			14058618	1	0	0	regulates ERK1/2 activation	
PKCA	EC 2.7.11.13; KINASE; Kinase, protein; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor)	P04409	282001	PRKCA		cow	T494	PHOSPHORYLATION	449889	EHMMDGVtTRTFCGT	Pkinase	enzymatic activity, induced				1884	2	2	2		
TrkB	EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Protein kinase, TK; Protein kinase, tyrosine (receptor)	Q16620	4915	NTRK2	9q22.1	human	Y706	PHOSPHORYLATION	448811	RDVYSTDyYRVGGHT	Pkinase_Tyr	phosphorylation				8867	9	1	52	autophosphorylation and ERK phosphorylation	
CHOP	Autophagy; DNA binding protein; Transcription factor	P35638	1649	DDIT3	12q13.1-q13.2	human	S31	PHOSPHORYLATION	455504	DLQEVLSsDENGGTY	CDC45; Peptidase_S64; Macoilin	activity, inhibited	transcription, inhibited			5475	1	0	0		
CDK16	EC 2.7.11.22; KINASE; Kinase, protein; Motility/polarity/chemotaxis; Protein kinase, CMGC; Protein kinase, Ser/Thr (non-receptor)	Q00536	5127	CDK16	Xp11	human	S119	PHOSPHORYLATION	453450	EDINKRLsLPADIRL		molecular association, regulation	cytoskeletal reorganization	14-3-3 beta(INDUCES); 14-3-3 zeta(INDUCES); 14-3-3 gamma(INDUCES)		3862	3	27	0		
hnRNP K	RNA binding protein; RNA splicing; Spliceosome	P61978	3190	HNRNPK	9q21.32-q21.33	human	S302	PHOSPHORYLATION	457408	GRGGRGGsRARNLPL		activity, induced; molecular association, regulation		PKCD(INDUCES)		7074; 11982	3	0	0		
MAP2	Cytoskeletal protein; Motility/polarity/chemotaxis	P11137	4133	MAP2	2q34-q35	human	S1679	PHOSPHORYLATION	456808	NVKSKIGsTDNIKYQ	Tubulin-binding	molecular association, regulation; intracellular localization	cytoskeletal reorganization	TUBA1A(INDUCES); ACTB(INDUCES)		7324105	2	3	0		
eNOS	Amino Acid Metabolism - arginine and proline; EC 1.14.13.39; Oxidoreductase	P29474	4846	NOS3	7q36	human	T495	PHOSPHORYLATION	447885	TGITRKKtFKEVANA		molecular association, regulation; enzymatic activity, inhibited		calmodulin(DISRUPTS)		4888101; 6234	56	1	1	crystallography data	
PTEN	Carbohydrate Metabolism - inositol phosphate; EC 3.1.3.16; EC 3.1.3.48; EC 3.1.3.67; Motility/polarity/chemotaxis; Nuclear receptor co-regulator; PHOSPHATASE; Phosphatase, lipid; Tumor suppressor	P60484	5728	PTEN	10q23.3	human	Y155	PHOSPHORYLATION	4000973	AQEALDFyGEVRTRD	DSPc	protein stabilization; molecular association, regulation		WWP2(DISRUPTS)		21387114	1	0	0		
Rb-like 2	Transcription, coactivator/corepressor	Q08999	5934	RBL2	16q12.2	human	S639	PHOSPHORYLATION	449726	DEICIAGsPLTPRRV		molecular association, regulation	cell cycle regulation	E2F4(DISRUPTS)		1200; 5981	3	10	21		
KHSRP	RNA binding protein	Q92945	8570	KHSRP	19p13.3	human	S670	PHOSPHORYLATION	482098	GPGAPPGsQPDYSAA	DUF1897	activity, induced; molecular association, regulation				18410826	1	1	2	binds to and functions in pri-miRNA processing	
P2RY1	GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR	P47900	5028	P2RY1	3q25.2	human	S352	PHOSPHORYLATION	1983719	RSEANLQsKSEDMTL		receptor internalization, altered				10353925; 17482924	2	1	0		
Ret	EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Protein kinase, TK; Protein kinase, tyrosine (receptor)	P07949	5979	RET	10q11.2	human	Y981	PHOSPHORYLATION	450703	DNCSEEMyRLMLQCW	Pkinase_Tyr	molecular association, regulation; enzymatic activity, induced		Src(INDUCES)		3282; 8770	6	1	0		
SMPD3	EC 3.1.4.12; Lipid Metabolism - sphingolipid; Membrane protein, integral; Phospholipase	Q9JJY3	58994	Smpd3		mouse	S289	PHOSPHORYLATION	4780074	QRDGDSGsLGSPSAS		protein stabilization; enzymatic activity, induced				22463914	1	10	2		
HEC1	Cell cycle regulation	O14777	10403	NDC80	18p11.32	human	T49	PHOSPHORYLATION	474512	KLSINKPtSERKVSL	Ndc80_HEC		cell cycle regulation			9229	1	0	0	mutation of six N-terminal residues (S5,S15,S44,T49,S55 and S69) to alanines interferes with mitosis	
Oct4	DNA binding protein; Transcription factor	Q01860	5460	POU5F1	6p21.31	human	S236	PHOSPHORYLATION	6738001	ARKRKRTsIENRVRG	Homeobox	molecular association, regulation	transcription, inhibited		DNA(DISRUPTS)	25227623	1	2	0		
HERC2	EC 6.3.2.-; EC 6.3.2.19; Ligase; Mitochondrial; UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase	O95714	8924	HERC2	15q13	human	T4827	PHOSPHORYLATION	12122400	DSFASDStQDYLTGH		molecular association, regulation; ubiquitination		RNF8(INDUCES)		12021303	2	0	0	stabilizes an interaction of RNF8 with MDC1 or Ubc13	
ITCH	EC 6.3.2.-; EC 6.3.2.19; Ligase; UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase	Q96J02	83737	ITCH	20q11.22	human	Y420	PHOSPHORYLATION	454077	QFNQRFIyGNQDLFA		molecular association, regulation		JunB(DISRUPTS)		7465	1	2	83		
Ctip	EC 3.1.-.-; Transcription, coactivator/corepressor	Q99708	5932	RBBP8	18q11.2	human	T859	PHOSPHORYLATION	27427901	WEVGFPStQTCMERG		molecular association, regulation			DNA(INDUCES)	27305552	1	0	0		
PGRMC1	Membrane protein, integral; Receptor, misc.	O00264	10857	PGRMC1	Xq22-q24	human	S57	PHOSPHORYLATION	452526	QPAASGDsDDDEPPP			apoptosis, altered			5007909	1	30	1		
Rb	Nuclear receptor co-regulator; Transcription, coactivator/corepressor; Tumor suppressor	P06400	5925	RB1	13q14.2	human	S780	PHOSPHORYLATION	447978	STRPPTLsPIPHIPR	Rb_C	protein degradation; molecular association, regulation; activity, inhibited	cell cycle regulation; apoptosis, inhibited; transcription, altered; cell growth, altered	E2F1(DISRUPTS); E2F1(INDUCES)		6449; 777; 6476; 6276; 1172203; 3412; 4759; 9401442	56	9	112	regulates endoreduplication; Phosphorylation of S780 by TGM2 induced dissociation of E2F1 from Rb.  	
ANPA	EC 4.6.1.2; Guanylyl cyclase; KINASE; Kinase, protein; Lyase; Membrane protein, integral; Nucleotide Metabolism - purine; Protein kinase, RGC; Protein kinase, dual-specificity; Receptor, misc.	P16066	4881	NPR1	1q21-q22	human	T545	PHOSPHORYLATION	447516	SNYGSLLtTEGQFQV	Pkinase_Tyr	activity, induced				896	2	2	0		
MyoD	DNA binding protein; RNA splicing; Transcription factor	P10085	17927	Myod1		mouse	Y156	PHOSPHORYLATION	18755302	ILRNAIRyIEGLQAL	HLH	protein stabilization; molecular association, regulation	transcription, altered	FBXO32(DISRUPTS)		18668240	1	1	0	stimulates skeletal myogenesis	
ATRIP	Cell cycle regulation; DNA binding protein; DNA repair	Q8WXE1	84126	ATRIP	3p21.31	human	S68	PHOSPHORYLATION	454388	EELDTLAsQALSQCP		intracellular localization				4265	1	0	0		
Kv3.3	Membrane protein, integral; Membrane protein, multi-pass	Q63959	16504	Kcnc3		mouse	S3	PHOSPHORYLATION	2840509	_____MLsSVCVWSF	Potassium_chann	activity, inhibited				2831761	1	0	0		
vinculin	Cell adhesion; Cytoskeletal protein; Motility/polarity/chemotaxis	P12003	396422	VCL		chicken	Y100	PHOSPHORYLATION	454004	QMLQADPySVPARDY	Vinculin	protein conformation	cell adhesion, altered			4154	1	3	54	phosphorylation of this site positively regulates cell spreading	
NGFR	Membrane protein, integral; Receptor, misc.	P07174	24596	Ngfr		rat	Y337	PHOSPHORYLATION	454435	LKGDGNLySSLPLTK		protein degradation; molecular association, regulation		Cbl(INDUCES)		4313	1	1	3		
tau iso8	Cytoskeletal protein	P10636-8	4137	MAPT	17q21.1	human	S352	PHOSPHORYLATION	487459	DFKDRVQsKIGSLDN	Tubulin-binding	molecular association, regulation				19084437	2	1	0	in vitro microtubule binding	
CCND1	Activator protein; Nuclear receptor co-regulator	P25322	12443	Ccnd1		mouse	T286	PHOSPHORYLATION	447839	EEAGLACtPTDVRDV		activity, induced; protein degradation; protein stabilization; molecular association, regulation; ubiquitination; intracellular localization	cell cycle regulation	Pin1(INDUCES)		6115913; 7309825; 5932; 6083; 2621600; 1464	25	2	1		
Notch 1	Membrane protein, integral; Motility/polarity/chemotaxis; Receptor, misc.; Transcription factor	P46531	4851	NOTCH1	9q34.3	human	S2523	PHOSPHORYLATION	467289	SPDQWSSsSPHSNVS	DUF3454	protein degradation; receptor inactivation, altered				8231	1	0	0	Alanine mutation of 4 serines (S2522/S2523/S2524/S2525) causes increased protein stability.	
PXN iso2	Adaptor/scaffold; Cell adhesion; Cytoskeletal protein; Motility/polarity/chemotaxis	P49023-2	5829	PXN	12q24.31	human	Y88	PHOSPHORYLATION	448909	PQSSSPVyGSSAKTS	Paxillin	phosphorylation	cell motility, altered; signaling pathway regulation; cell growth, altered			12525221	3	31	1366	Y88A mutation  decreases PDGF-AA-induced phosphorylation of Akt T308 and Y473, p130CAS Y165 and SHP2 Y542	
CACNB2	Channel, calcium	Q8VGC3	116600	Cacnb2		rat	S625	PHOSPHORYLATION	469619	KQRSRHKsKDRYCDK		intracellular localization				8323	2	0	0		
G-alpha(z)	Endoplasmic reticulum; G protein, heterotrimeric; G protein, heterotrimeric alpha G((i/o/t/z)); Nuclear envelope	P19086	2781	GNAZ	22q11.22	human	S16	PHOSPHORYLATION	451242	EKEAARRsRRIDRHL	G-alpha; DUF2951	activity, induced; protein conformation				11484423	3	0	2		
p70S6K	EC 2.7.11.-; EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor); Translation	Q8BSK8	72508	Rps6kb1		mouse	S434	PHOSPHORYLATION	448356	SFEPKIRsPRRFIGS		molecular association, regulation		DEDD(INDUCES)		7119509	25	1	0	Association with DEDD in vitro and in vivo  prevents inhibitory phosphorylation by Cdk1 at S434, T444, and S447.	
SLITRK1	Cell development/differentiation; Membrane protein, integral	Q96PX8	114798	SLITRK1	13q31.1	human	S695	PHOSPHORYLATION	4749248	DCGSHSLsD______		molecular association, regulation	cell growth, altered	14-3-3 beta(INDUCES)		11484412	1	4	0		
CCKBR	GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR	P32239	887	CCKBR	11p15.4	human	S437	PHOSPHORYLATION	17825901	IASLSRLsYTTISTL		molecular association, regulation		ARRB1(INDUCES)		17675032	1	0	0		
C/EBP-beta	DNA binding protein; Motility/polarity/chemotaxis; Transcription factor	P28033	12608	Cebpb		mouse	T179	PHOSPHORYLATION	455887	GSSGSLStSSSSSPP		activity, induced; molecular association, regulation; protein conformation	cell cycle regulation; cell differentiation, altered; transcription, altered	C/EBP-beta(INDUCES)	DNA(INDUCES)	2653912; 6368; 1173006	6	1	0		
DACT1	Adaptor/scaffold	Q9NYF0	51339	DACT1	14q23.1	human	S827	PHOSPHORYLATION	18159800	KKILRFRsGSLKLMT		molecular association, regulation	carcinogenesis, altered; cell growth, altered	14-3-3 beta(INDUCES)		18021025	1	1	0	 ; modulates Wnt signaling	
PKCA	EC 2.7.11.13; KINASE; Kinase, protein; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor)	P04409	282001	PRKCA		cow	S657	PHOSPHORYLATION	448597	QSDFEGFsYVNPQFV	Pkinase_C	activity, induced; protein stabilization; protein conformation; enzymatic activity, induced; phosphorylation				4052; 1237; 11484403	22	2	2	stabilization in membrane	
PDGFRA	EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Protein kinase, TK; Protein kinase, tyrosine (receptor)	P16234	5156	PDGFRA	4q12	human	Y1018	PHOSPHORYLATION	448647	RLSADSGyIIPLPDI		molecular association, regulation		PLCG1(INDUCES)		4332; 3744	3	7	98		
NHE3	Membrane protein, integral; Membrane protein, multi-pass; Transporter	P26433	24784	Slc9a3		rat	S552	PHOSPHORYLATION	450899	AEGERRGsLAFIRSP		molecular association, regulation; intracellular localization; activity, inhibited		SYT1(INDUCES)		11390404; 3184; 8680; 15022735; 4596	16	4	4		
C/EBP-alpha	DNA binding protein; Transcription factor	P53566	12606	Cebpa		mouse	S193	PHOSPHORYLATION	457552	PPPHPHAsPAHLAAP		protein degradation; molecular association, regulation; ubiquitination	cell cycle regulation; carcinogenesis, altered; transcription, inhibited; transcription, altered; cell growth, altered	CDK2(INDUCES); SMARCA2(INDUCES); E2F4(INDUCES); HDAC1(INDUCES); BRMS1L(INDUCES); CDK4(INDUCES); PSMD10(INDUCES); Rb(DISRUPTS); HP1 alpha(INDUCES); C/EBP-beta(INDUCES)		17482902; 14743112; 9370; 7845; 7101	7	0	0	;  leads to elevation of heterochromatin regions in nuclei;  activates Glut4 promoter; S193D mutation influences liver morphology - decreases the number of hepatocytes and increases their size	
CREB	DNA binding protein; Transcription factor	Q01147	12912	Creb1		mouse	S142	PHOSPHORYLATION	448547	RKILNDLsSDAPGVP	pKID	activity, induced	transcription, altered			2776	10	10	2	resetting circadian clock such as for locomotor activity	
CUTL1	DNA binding protein; Membrane protein, integral; Transcription factor	P53564	13047	Cux1		mouse	S972	PHOSPHORYLATION	457410	VLGLSQGsVSDMLSR	CUT	molecular association, regulation	transcription, altered		DNA(DISRUPTS)	7046	1	0	0	 	
PAK1	EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, STE; Protein kinase, Ser/Thr (non-receptor)	O88643	18479	Pak1		mouse	T212	PHOSPHORYLATION	448176	VIEPLPVtPTRDVAT		molecular association, regulation; intracellular localization	cell motility, altered; cytoskeletal reorganization			1218; 5011219; 7799	9	15	17	during mitosis	
Fyn	EC 2.7.10.2; KINASE; Kinase, protein; Protein kinase, TK; Protein kinase, tyrosine (non-receptor)	P39688	14360	Fyn		mouse	Y28	PHOSPHORYLATION	447879	SLNQSSGyRYGTDPT		enzymatic activity, inhibited				1101	2	2	10	Y527F mutation converted Fyn into a dominant oncoprotein, capable of full transformation of rodent fibroblasts.	
SGO1	Cell cycle regulation	Q9CXH7	72415	Sgol1		mouse	T146	PHOSPHORYLATION	2535905	QQIAVEEtDCPYQTT		intracellular localization				2425200	1	0	0	S73A and T146A mutants do not localize to the spindle pole region	
PKCB iso2	EC 2.7.11.13; KINASE; Kinase, protein; Motility/polarity/chemotaxis; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor)	P68403-2	25023	Prkcb		rat	T500	PHOSPHORYLATION	447896	WDGVTTKtFCGTPDY	Pkinase	enzymatic activity, induced				12482209	8	26	35		
Shc1	Adaptor/scaffold; Apoptosis; Mitochondrial; Motility/polarity/chemotaxis	P98083	20416	Shc1		mouse	Y423	PHOSPHORYLATION	448511	ELFDDPSyVNIQNLD		activity, induced; molecular association, regulation; phosphorylation	cell differentiation, altered; apoptosis, induced	SHIP(INDUCES); Grb2(INDUCES)		6563; 6347; 3053; 7324130; 6039	36	61	1965	in vitro and in vivo	
KIR2DL1	Membrane protein, integral; Receptor, misc.	P43626	3802	KIR2DL1	19q13.4	human	Y332	PHOSPHORYLATION	18500400	PPTDIIVyTELPNAE		molecular association, regulation	signaling pathway regulation	supervillin(INDUCES)		18410808	1	0	0	supervillin is required for KIR2DL1-mediated inhibition of Vav1 and Erk phosphorylation	
Hrs	Adaptor/scaffold; Motility/polarity/chemotaxis	O14964	9146	HGS	17q25	human	Y334	PHOSPHORYLATION	450192	ARYLNRNyWEKKQEE		intracellular localization; receptor recycling, altered; phosphorylation				2853; 9129	2	11	256	Hrs phosphorylation mutant Y329,334F is unable to degrade ubiquinated EGFR.   ; Cbl expression alters Hrs phosphorylation and fractionation in membrane and cyosokic fractions. 	
CFTR	Channel, chloride; EC 3.6.3.49; Hydrolase; Membrane protein, integral; Membrane protein, multi-pass; Transporter	P13569	1080	CFTR	7q31.2	human	S707	PHOSPHORYLATION	2907509	SILNPINsIRKFSIV	CFTR_R	activity, induced				8384	2	0	0		
Kv11.1	Channel, potassium; Membrane protein, integral; Membrane protein, multi-pass; Motility/polarity/chemotaxis	Q12809	3757	KCNH2	7q36.1	human	S1137	PHOSPHORYLATION	4696829	EGPTRRLsLPGQLGA		activity, induced; molecular association, regulation; activity, inhibited		14-3-3 eta(INDUCES)		10293701; 10292905	3	7	6	rapid reduction in channel current; 14-3-3 binding stabilizes phosphorylation of KV11.1, prolonging its activation	
APS	Adaptor/scaffold	Q9Z200	114203	Sh2b2		rat	S588	PHOSPHORYLATION	456846	SARSRSNsTEHLLEA		intracellular localization				6836	1	2	0		
ARHGAP24	GTPase activating protein, Rac/Rho; Motility/polarity/chemotaxis	Q8N264	83478	ARHGAP24	4q22.1	human	S391	PHOSPHORYLATION	484901	RSSMNNGsPTALSGS		activity, induced	cytoskeletal reorganization			12482285	1	4	0	membrane blebbing	
LEF-1	DNA binding protein; Transcription factor	Q9UJU2	51176	LEF1	4q23-q25	human	S166	PHOSPHORYLATION	11499000	TYSDEHFsPGSHPSH	CTNNB1_binding		transcription, inhibited			10294002	1	0	1		
ZAP70	EC 2.7.10.2; KINASE; Kinase, protein; Protein kinase, TK; Protein kinase, tyrosine (non-receptor)	P43403	7535	ZAP70	2q12	human	Y315	PHOSPHORYLATION	448867	MPMDTSVyESPYSDP		molecular association, regulation; enzymatic activity, induced; phosphorylation	cell differentiation, altered; cell adhesion, altered	Crk(INDUCES); VAV1(INDUCES)		3767; 7394; 852	6	4	285	leads to increased ZAP70, CD3-Zeta and PLC-gamma-1 phosphorylation; increases PI3K activation and adhesion	
PAG	Adaptor/scaffold; Membrane protein, integral	Q9NWQ8	55824	PAG1	8q21.13	human	Y317	PHOSPHORYLATION	450659	EEEISAMySSVNKPG		molecular association, regulation		CSK(INDUCES)		9564	8	17	623		
HDAC9	DEACETYLASE; Deacetylase; EC 3.5.1.98; Transcription, coactivator/corepressor	Q99N13	79221	Hdac9		mouse	S240	PHOSPHORYLATION	4772328	KVAERRSsPLLRRKD		intracellular localization				12482282	1	7	1	decreased nuclear localization	
NKX2-5	DNA binding protein	P42582	18091	Nkx2-5		mouse	S163	PHOSPHORYLATION	465563	FKQQRYLsAPERDQL	Homeobox		transcription, altered			8024	1	0	1		
WAVE2	Actin binding protein; Motility/polarity/chemotaxis	Q9Y6W5	10163	WASF2	1p36.11	human	S343	PHOSPHORYLATION	18715501	PPPVGFGsPGTPPPP		molecular association, regulation	cell motility, altered; cytoskeletal reorganization			18668222	1	0	0	regulates WRC (WAVE2 regulatory complex) interaction with Arp2/3 and lamellipodial protrusion	
PDK1	EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor)	O15530	5170	PDPK1	16p13.3	human	Y376	PHOSPHORYLATION	447695	DEDCYGNyDNLLSQF		enzymatic activity, induced	apoptosis, altered			15658705; 748; 12725501	8	1	0		
CRMP-2	Microtubule binding protein; Motility/polarity/chemotaxis	O08553	12934	Dpysl2		mouse	T555	PHOSPHORYLATION	448084	DNIPRRTtQRIVAPP			cell growth, altered			15755122	8	0	8		
DLC1	GTPase activating protein, Rac/Rho	Q96QB1	10395	DLC1	8p22	human	S1244	PHOSPHORYLATION	17538201	NTLKRENsSPRVMQR		activity, inhibited	cell growth, altered			17482915	1	1	0		
PKCB	EC 2.7.11.13; KINASE; Kinase, protein; Motility/polarity/chemotaxis; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor)	P04410	25023	Prkcb		rat	T500	PHOSPHORYLATION	447896	WDGVTTKtFCGTPDY	Pkinase	enzymatic activity, induced				25785427	8	26	35		
PHOX2A	DNA binding protein; Transcription factor	O14813	401	PHOX2A	11q13.2	human	S153	PHOSPHORYLATION	9400302	RKQERAAsAKGAAGA		molecular association, regulation; activity, inhibited	transcription, inhibited		DNA(DISRUPTS)	9158113	1	1	1	 inhibits neuronal differentiation; dominant-negative effect on PHOX2A activity	
DARPP-32	Motility/polarity/chemotaxis; Protein phosphatase, regulatory subunit	Q6J4I0	360616	Ppp1r1b		rat	S137	PHOSPHORYLATION	448046	EEDEEEDsQAEVLKG	DARPP-32; Drc1-Sld2; SPX; PPP4R2; Nucleoplasmin; Nop14; PAPA-1; NOA36	phosphorylation				7324118	12	1	8	Dephosphorylation of S137 by PPP3CAis inhibited. 	
MDC1	Cell cycle regulation	Q14676	9656	MDC1	6p21.3	human	S402	PHOSPHORYLATION	3196337	QASMVINsDTDDEEE		molecular association, regulation	cell cycle regulation	NBS1(INDUCES)		4042508	1	11	8	MDC1-NBS1 interaction regulates intra-S-phase checkpoint activation	
DYRK1A	EC 2.7.12.1; EC 2.7.12.2; KINASE; Kinase, protein; Protein kinase, CMGC; Protein kinase, dual-specificity	Q63470	25255	Dyrk1a		rat	Y319	PHOSPHORYLATION	457973	CQLGQRIyQYIQSRF	Pkinase	enzymatic activity, induced				2852630	1	11	186		
Shc1 iso3	Adaptor/scaffold; Apoptosis; Mitochondrial; Motility/polarity/chemotaxis	P29353-3	6464	SHC1	1q21	human	Y272	PHOSPHORYLATION	448511	ELFDDPSyVNVQNLD		phosphorylation				673	36	61	1965	Either FAK Y925 or Shc1 Y317 need to be phosphorylated after fibronectin to bind Grb2 to effficiently activate ERKs.	
DRP1	Apoptosis; EC 3.6.5.5; Endoplasmic reticulum; Hydrolase; Microtubule binding protein; Mitochondrial; Motor protein	O00429	10059	DNM1L	12p11.21	human	S637	PHOSPHORYLATION	483971	VPVARKLsAREQRDC		molecular association, regulation; intracellular localization; enzymatic activity, inhibited; protein conformation		DRP1(NOT_REPORTED)		11958; 6315400	8	0	0	impairs intramolecular interactions and GTPase activity;  inhibits mitochondrial division; dephosphorylated DRP1 translocates to mitochondreia 	
ALK	EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Protein kinase, TK; Protein kinase, tyrosine (receptor)	Q9UM73	238	ALK	2p23	human	Y1507	PHOSPHORYLATION	450379	TSLWNPTyGSWFTEK		molecular association, regulation		Shc1(INDUCES)		9236	1	6	92		
NIPA	Cell cycle regulation; Ubiquitin conjugating system	Q86WB0	51530	ZC3HC1	7q32.2	human	S395	PHOSPHORYLATION	478573	PGLEVPSsPLRKAKR		molecular association, regulation	cell cycle regulation	SKP1A(DISRUPTS)		11952	3	27	22		
MAPKAPK2	EC 2.7.1.-; EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, CAMK; Protein kinase, Ser/Thr (non-receptor)	P49138	17164	Mapkapk2		mouse	T208	PHOSPHORYLATION	448269	TSHNSLTtPCYTPYY	Pkinase	enzymatic activity, induced				2602	11	1	39		
BCAP	Adaptor/scaffold	Q9DDT2	374268	PIK3AP1		chicken	Y448	PHOSPHORYLATION	448184	PGSDEELyESMAGFV		molecular association, regulation		PIK3R1(INDUCES)		1374	2	0	0		
ANPB	EC 4.6.1.2; Guanylyl cyclase; KINASE; Kinase, protein; Lyase; Membrane protein, integral; Nucleotide Metabolism - purine; Protein kinase, RGC; Protein kinase, dual-specificity; Receptor, misc.	P20594	4882	NPR2	9p21-p12	human	Y808	PHOSPHORYLATION	27930810	LLLRMEQyANNLEKL	HNOBA	enzymatic activity, altered				27902336	1	0	0		
GRK2	EC 2.7.11.15; KINASE; Kinase, protein; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor)	P21146	282682	ADRBK1		cow	Y92	PHOSPHORYLATION	456873	FYEEIKKyEKLETEE	RGS	enzymatic activity, induced				2831776	5	0	0		
C/EBP-alpha	DNA binding protein; Transcription factor	P53566	12606	Cebpa		mouse	T222	PHOSPHORYLATION	449824	HLQPGHPtPPPTPVP			transcription, induced; transcription, inhibited			9370; 2369	6	0	0		
IRS1	Adaptor/scaffold; Motility/polarity/chemotaxis	P35568	3667	IRS1	2q36	human	Y632	PHOSPHORYLATION	447565	GRKGSGDyMPMSPKS		molecular association, regulation		PIK3R1(INDUCES)		1140	6	7	280		
ADRB2	GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR	P07550	154	ADRB2	5q31-q32	human	S345	PHOSPHORYLATION	447910	ELLCLRRsSLKAYGN		receptor desensitization, altered				1642	7	0	0		
SCN2A	Channel, sodium; Membrane protein, integral; Membrane protein, multi-pass	P04775	24766	Scn2a		rat	S1124	PHOSPHORYLATION	6003506	LNTEEFSsESDMEES	Na_trans_assoc	intracellular localization				5930021	1	0	0	regulates SCN2A accumulation at the axonal initial segment (AIS) and interaction with ankyrin G	
TrkA iso2	EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Protein kinase, TK; Protein kinase, tyrosine (receptor)	P04629-2	4914	NTRK1	1q21-q22	human	Y490	PHOSPHORYLATION	447762	HIIENPQyFSDACVH		enzymatic activity, induced				1305	17	0	2		
p73	DNA binding protein; Transcription factor	O15350	7161	TP73	1p36.3	human	T86	PHOSPHORYLATION	449047	AASASPYtPEHAASV		protein degradation; intracellular localization; activity, inhibited	apoptosis, induced; chromatin organization, altered; transcription, inhibited	p73(DISRUPTS)		2082; 7185; 23013819	3	0	0		
FAK	EC 2.7.1.112; EC 2.7.10.2; KINASE; Kinase, protein; Protein kinase, TK; Protein kinase, tyrosine (non-receptor)	Q05397	5747	PTK2	8q24.3	human	Y925	PHOSPHORYLATION	447966	DRSNDKVyENVTGLV	Focal_AT	molecular association, regulation; intracellular localization; phosphorylation	cell differentiation, altered; cell motility, altered; apoptosis, inhibited; cytoskeletal reorganization; cell adhesion, altered; transcription, altered	PXN(DISRUPTS); Grb2(INDUCES)		4894710; 5625; 19016933; 4894707; 3433201; 2865401; 2862; 5930	70	10	434	regulates focal adhesion disassembly and cell protrusion	
PDK1	EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor)	Q9Z2A0	18607	Pdpk1		mouse	S163	PHOSPHORYLATION	465670	EKLYFGLsYAKNGEL	Pkinase; YukC	protein conformation; enzymatic activity, induced				8079	1	1	0		
STAT4	DNA binding protein; Transcription factor	P42228	20849	Stat4		mouse	Y694	PHOSPHORYLATION	447790	TERGDKGyVPSVFIP		activity, induced; molecular association, regulation; intracellular localization; activity, inhibited; phosphorylation	cell differentiation, altered; transcription, altered; cell growth, altered	FHL1 iso1(INDUCES)	DNA(INDUCES)	1284; 8832; 6916	8	2	3	phosphorylation of STAT4 S722	
14-3-3 zeta	Adaptor/scaffold; Motility/polarity/chemotaxis	P63104	7534	YWHAZ	8q23.1	human	S58	PHOSPHORYLATION	449833	VVGARRSsWRVVSSI	14-3-3; FliM	protein degradation; molecular association, regulation	apoptosis, altered	14-3-3 zeta(DISRUPTS); 14-3-3 zeta(INDUCES); tau iso3(DISRUPTS); ASK1(DISRUPTS); 14-3-3 epsilon(DISRUPTS); p53(DISRUPTS); HSP20(DISRUPTS)		7370; 18415100; 7889917; 4651305; 3521	11	1	5		
ATP4A	EC 3.6.3.10; Energy Metabolism - oxidative phosphorylation; Hydrolase; Membrane protein, integral; Membrane protein, multi-pass	P20648	495	ATP4A	19q13.1	human	Y7	PHOSPHORYLATION	484289	_MGKAENyELYSVEL	H-K_ATPase_N	protein conformation				8543	2	0	10	Structure indicates tyrosine sequential phosphorylation at Y10 and subsequent Y7 which may induce activation of ATP4A.  	
SMC3	Cell cycle regulation; DNA repair	Q9UQE7	9126	SMC3	10q25	human	S1067	PHOSPHORYLATION	453059	GDVEGSQsQDEGEGS	SMC_N	phosphorylation	cell cycle regulation			3301215	1	32	27	facilitates phosphorylation of S1083; required for intra-S phase checkpoint	
ANXA2	Calcium-binding protein; Lipid binding protein; Motility/polarity/chemotaxis	P07355	302	ANXA2	15q22.2	human	Y24	PHOSPHORYLATION	449483	HSTPPSAyGSVKAYT		molecular association, regulation; intracellular localization				27619376; 6702305; 4226	7	34	2601	essential for association with endosomes; extracellular localization-in vitro capillary-like network	
calponin 3	Cytoskeletal protein; Motility/polarity/chemotaxis	Q15417	1266	CNN3	1p22-p21	human	S296	PHOSPHORYLATION	4776198	GTNGSEIsDSDYQAE		molecular association, regulation	cytoskeletal reorganization			15562513	2	3	6	stimulates dissociation of calponin 3 from actin cytoskeleton (F-actin)	
IkB-alpha	DNA binding protein; Inhibitor protein	P25963	4792	NFKBIA	14q13	human	S283	PHOSPHORYLATION	451523	NLQMLPEsEDEESYD		protein degradation				12482204	3	0	0	S283/T291/T299A  triple mutant showed increased IkB-alpha stability.	
TrkA iso2	EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Protein kinase, TK; Protein kinase, tyrosine (receptor)	P04629-2	4914	NTRK1	1q21-q22	human	Y674	PHOSPHORYLATION	447763	RDIYSTDyYRVGGRT	Pkinase_Tyr	enzymatic activity, induced				1305	9	2	10		
diaphanous 2 iso4	Cytoskeletal protein; Motility/polarity/chemotaxis	Q17R91	1730	DIAPH2	Xq21.33	human	S820	PHOSPHORYLATION	18707505	HINNIKPsIIAVTLA	FH2		cell cycle regulation; chromatin organization, altered; cytoskeletal reorganization			18668219	1	0	0	mutation of this site disrupts metaphase chromosome alignment	
CTNNB1	Actin binding protein; Cell adhesion; Motility/polarity/chemotaxis; Nuclear receptor co-regulator; Transcription factor	Q02248	12387	Ctnnb1		mouse	S191	PHOSPHORYLATION	467710	SRHAIMRsPQMVSAI	HEAT_2; RIX1	intracellular localization				2915500	2	24	11		
CtBP1	Cell cycle regulation; EC 1.1.1.-; Nuclear receptor co-regulator; Oxidoreductase; Transcription, coactivator/corepressor	Q13363	1487	CTBP1	4p16	human	S422	PHOSPHORYLATION	455350	AHPPHAPsPGQTVKP		protein degradation	apoptosis, induced			8921; 4585; 13251001	3	0	0		
BRSK1	EC 2.7.11.1; EC 2.7.11.26; KINASE; Kinase, protein; Protein kinase, CAMK; Protein kinase, Ser/Thr (non-receptor)	Q5RJI5	381979	Brsk1		mouse	T189	PHOSPHORYLATION	456027	VGDSLLEtSCGSPHY	Pkinase		cytoskeletal reorganization	BRSK1(INDUCES)		1193006	6	1	0	LKB1 phosphorylates Brsk1 and Brsk2.	
Syk	EC 2.7.10.2; KINASE; Kinase, protein; Protein kinase, TK; Protein kinase, tyrosine (non-receptor)	Q64725	25155	Syk		rat	Y625	PHOSPHORYLATION	459327	LRLRNYYyDVVN___		molecular association, regulation; phosphorylation; enzymatic activity, induced		FcER1G(INDUCES)		14780510	1	0	2	; mutation of this site stimulates phosphorylation of Y317, Y519 and Y520;  required for activation of ERK1/2 and p38MAP kinases;  required for activation of NFAT and NFkB	
DARPP-32	Motility/polarity/chemotaxis; Protein phosphatase, regulatory subunit	Q60829	19049	Ppp1r1b		mouse	S97	PHOSPHORYLATION	457675	NLSENQAsEEEDELG	DARPP-32; PPP4R2; Nop14; Nucleoplasmin; NOA36	intracellular localization; phosphorylation				4264912	6	8	22	histone H3 phosphorylation	
ITGB7	Cell adhesion; Membrane protein, integral; Motility/polarity/chemotaxis; Receptor, misc.	P26010	3695	ITGB7	12q13.13	human	Y753	PHOSPHORYLATION	469601	YRLSVEIyDRREYSR	Integrin_b_cyt		cell adhesion, altered			8233	1	0	1		
PHLDA1	Apoptosis	Q8WV24	22822	PHLDA1	12q15	human	S95	PHOSPHORYLATION	22459800	PLCLLRVsLLCALRA		protein degradation; intracellular localization	carcinogenesis, induced; cell motility, induced; apoptosis, induced			22459500	1	0	0	 ; S95A mutant promotes Aurora A degradation and ubiquitylation	
VAV1	Guanine nucleotide exchange factor, Rac/Rho; Motility/polarity/chemotaxis	P15498	7409	VAV1	19p13.2	human	Y142	PHOSPHORYLATION	448809	SVGDEDIySGLSDQI		molecular association, regulation		PLCG1(INDUCES); Lck(INDUCES); PIK3R1(INDUCES)		2587209	3	0	0		
SLC12A3	Membrane protein, integral; Membrane protein, multi-pass; Transporter	P55018	54300	Slc12a3		rat	S124	PHOSPHORYLATION	4709872	EDETGANsEKSPGEP		activity, induced				27132423	1	2	0		
SPT5	Transcription, coactivator/corepressor	O00267	6829	SUPT5H	19q13	human	T784	PHOSPHORYLATION	458816	MYGSGSRtPMYGSQT	CTD		transcription, altered			7460	1	0	10	required for c-fos induction and activation in vivo	
Akt1	EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor)	P31750	11651	Akt1		mouse	Y315	PHOSPHORYLATION	448519	TFCGTPEyLAPEVLE	Pkinase	enzymatic activity, induced	apoptosis, altered			449; 15331019	4	2	12		
CCR7	GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Motility/polarity/chemotaxis; Receptor, GPCR	P32248	1236	CCR7	17q12-q21.2	human	T375	PHOSPHORYLATION	455290	VEAETTTtFSP____		phosphorylation				4472	1	0	0	ERK1/2 phosphorylation	
PAR3-alpha	Adaptor/scaffold; Motility/polarity/chemotaxis	Q8TEW0	56288	PARD3	10p11.21	human	S889	PHOSPHORYLATION	455653	LGLKKSSsLESLQTA		molecular association, regulation		14-3-3 zeta(INDUCES)		5512	2	1	0		
C/EBP-beta	DNA binding protein; Motility/polarity/chemotaxis; Transcription factor	P28033	12608	Cebpb		mouse	T217	PHOSPHORYLATION	448447	AKAKAKKtVDKLSDE	DUF2514; Nup54; DUF2730	molecular association, regulation	cell cycle regulation; apoptosis, inhibited; cell growth, altered	Casp8(INDUCES); Casp1(INDUCES)		6452; 618	4	0	0		
ANTXR2	Membrane protein, integral; Receptor, misc.	P58335	118429	ANTXR2	4q21.21	human	Y380	PHOSPHORYLATION	3781577	WPTVDASyYGGRGVG	DUF3328	ubiquitination				13270511	1	6	105		
CARD11	Adaptor/scaffold	Q6KAS3	108723	Card11		mouse	S564	PHOSPHORYLATION	457637	QPHRSRSsIMSITAE		activity, induced; molecular association, regulation		Bcl-10(INDUCES)		7271; 11419355	4	1	0		
hnRNP A1	RNA binding protein; RNA splicing; Spliceosome	P04256	29578	Hnrnpa1		rat	S95	PHOSPHORYLATION	476057	RAVSREDsQRPGAHL		activity, inhibited				2852618	1	5	2		
ADRB2	GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR	P07550	154	ADRB2	5q31-q32	human	Y219	PHOSPHORYLATION	4047200	LVIMVFVySRVFQEA	7tm_1; TM	activity, induced				970035	1	0	0	G-protein activation	
Cdc25B	EC 3.1.3.48; Motility/polarity/chemotaxis; Nuclear receptor co-regulator; PHOSPHATASE; Protein phosphatase, dual-specificity	P30305	994	CDC25B	20p13	human	T355	PHOSPHORYLATION	3189697	NKRRRSVtPPEEQQE	M-inducer_phosp		cell cycle regulation			30280007	1	3	5		
ADRB2	GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR	P04274	101836719	Adrb2		hamster	Y350	PHOSPHORYLATION	449808	RRSSSKAyGNGYSSN		molecular association, regulation; receptor desensitization, altered		Src(INDUCES)		1109	7	0	0		
SIK	EC 2.7.11.1; KINASE; Kinase, protein; Motility/polarity/chemotaxis; Protein kinase, CAMK; Protein kinase, Ser/Thr (non-receptor)	Q60670	17691	Sik1		mouse	S577	PHOSPHORYLATION	465992	FQEGRRAsDTSLTQG		intracellular localization	transcription, altered			5339; 8811	8	7	4		
MDM2	EC 6.3.2.-; EC 6.3.2.19; Inhibitor protein; Ligase; UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase	Q00987	4193	MDM2	12q14.3-q15	human	S260	PHOSPHORYLATION	454923	SLDSEDYsLSEEGQE		activity, induced; protein degradation; molecular association, regulation; ubiquitination; enzymatic activity, induced		Rb(DISRUPTS)		8633; 27102302; 11270011; 4379	6	1	0	promotes p53 degradation; stimulates p53 turnover; Rb degradation ; Phosphorylated S260 and S395 and  S260D and S395D mutant peptides inhibited binding of binding of a specific monoclonal antibody raised to Mdm2. Phosphorylation of Mdm2 regulates p53 degradation. 	
TRPV1	Channel, cation; Membrane protein, integral; Membrane protein, multi-pass; Receptor, misc.	O35433	83810	Trpv1		rat	Y199	PHOSPHORYLATION	458384	ASYTDSYyKGQTALH		activity, induced				11821	2	0	0	altered desensitization	
GLUT4	Membrane protein, integral; Membrane protein, multi-pass; Transporter	P19357	25139	Slc2a4		rat	S488	PHOSPHORYLATION	451207	ATFRRTPsLLEQEVK		intracellular localization				3294	2	4	0	S488A mutation had no effect on localization to  cell surface, but vesicle localization was significantly increased.	
CLK2	EC 2.7.12.1; KINASE; Kinase, protein; Protein kinase, CMGC; Protein kinase, dual-specificity	P49760	1196	CLK2	1q21	human	S34	PHOSPHORYLATION	15339201	HKRRRSRsWSSSSDR			apoptosis, altered; cell growth, altered			15235213	1	0	0		
NTSR2	GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR	P70310	18217	Ntsr2		mouse	Y237	PHOSPHORYLATION	3129400	VNHLVALySQVPSAS	7tm_1; TM	receptor recycling, altered				8692	1	0	0	NT stimulation led to large intracellular vesicles under the plasma membrane in the Y238A mutant. 	
ACTN1	Cytoskeletal protein; Motility/polarity/chemotaxis	P12814	87	ACTN1	14q24|14q22-q24	human	Y12	PHOSPHORYLATION	450200	DSQQTNDyMQPEEDW		molecular association, regulation; phosphorylation	cell motility, altered; cytoskeletal reorganization	Src(INDUCES); ITGA2b(INDUCES)		27623406; 18410810; 1880601	4	1	4	required for dorsal stress fiber establishment, transverse arc maintenance, and focal adhesion maturation; inhibits PAR1-induced ITGA2b activation in CMK; Phosphorylation of ACTN1 Y12 is required for PTP 1B to dephosphorylate FAK Y397.  Y12F mutation or no expression of ACTN1 significantly decreases the FAK Y397 dephosphorylation by PTP 1B.   Src's binding to phospho-Y12 ACTN1 competes with Src's binding to FAK.	
ADCY6	Adenylyl cyclase; EC 4.6.1.1; Lyase; Membrane protein, integral; Membrane protein, multi-pass; Nucleotide Metabolism - purine	AAA40678	25289	Adcy6		rat	S754	PHOSPHORYLATION	467275	IVRSRVHsTAVGVFS		enzymatic activity, induced				8212; 8211	2	0	0		
CD3Z	Membrane protein, integral; Receptor, misc.	P20963	919	CD247	1q24.2	human	Y123	PHOSPHORYLATION	448934	KDKMAEAySEIGMKG	ITAM	intracellular localization; phosphorylation				6115909; 2576201	3	10	329		
lamin A/C	Cytoskeletal protein	P02545	4000	LMNA	1q22	human	T19	PHOSPHORYLATION	459855	SGAQASStPLSPTRI	IncA		cell cycle regulation			7523	2	24	46	dominant negative mitotic affects, and mitotic assembly and disassembly of lamin	
TNNI3	Actin binding protein; Motility/polarity/chemotaxis; Motor protein	P23693	29248	Tnni3		rat	S151	PHOSPHORYLATION	451822	TLRRVRIsADAMMQA	Troponin	molecular association, regulation; protein conformation		TNNC1(INDUCES)		14790305	5	2	0		
HDAC4	DEACETYLASE; Deacetylase; EC 3.5.1.98; Hydrolase; Nuclear receptor co-regulator	P56524	9759	HDAC4	2q37.3	human	S632	PHOSPHORYLATION	448490	RPLSRAQsSPASATF		molecular association, regulation; intracellular localization	transcription, altered	14-3-3 beta(INDUCES); 14-3-3 epsilon(INDUCES)		2586; 1116	4	15	60		
DAP	Autophagy	P51397	1611	DAP	5p15.2	human	S51	PHOSPHORYLATION	471098	DQEWESPsPPKPTVF		activity, inhibited	autophagy, altered			14551420	1	24	1	dephosphorylated form of DAP acts as an active suppressor of autophagy 	
STAP2	Adaptor/scaffold	Q9UGK3	55620	STAP2	19p13.3	human	Y250	PHOSPHORYLATION	478353	PFLLDEDyEKVLGYV			transcription, altered			10294000	3	0	25		
KSR	KINASE; Kinase, protein; Protein kinase, Ser/Thr (non-receptor); Protein kinase, TKL	Q61097	16706	Ksr1		mouse	T274	PHOSPHORYLATION	449299	AKLKPPRtPPPPSRK		protein degradation; intracellular localization	cell cycle regulation; cell growth, altered			4282; 2169	4	2	1		
prolactin	Cytokine; Motility/polarity/chemotaxis; Secreted; Secreted, signal peptide	P01236	5617	PRL	6p22.2-p21.3	human	S207	PHOSPHORYLATION	451732	LHCLRRDsHKIDNYL	Hormone_1	protein conformation				9721206	3	1	0	phosphorylated form of prolactin has a higher affinity for heparin	
SH3BP2	Adaptor/scaffold	P78314	6452	SH3BP2	4p16.3	human	Y183	PHOSPHORYLATION	449092	HDDEDDSyLEPDSPE		molecular association, regulation	transcription, altered	VAV1(INDUCES)		5235	3	0	0		
P130Cas	Adaptor/scaffold; Motility/polarity/chemotaxis	P56945	9564	BCAR1	16q23.1	human	S639	PHOSPHORYLATION	470438	IQSRPLPsPPKFTSQ		intracellular localization	cell motility, altered			7964804	1	4	0		
Grb2	Adaptor/scaffold; Cell development/differentiation; Motility/polarity/chemotaxis	P62993	2885	GRB2	17q24-q25	human	Y209	PHOSPHORYLATION	448512	TGMFPRNyVTPVNRN		molecular association, regulation	cell growth, altered	SOS1(DISRUPTS)		7324303; 1384	3	2	179	regulates cell proliferation	
4E-BP1	Translation; Translation initiation	Q60876	13685	Eif4ebp1		mouse	T45	PHOSPHORYLATION	447496	GGTLFSTtPGGTRII	eIF_4EBP	molecular association, regulation		eIF4E(DISRUPTS); eIF4E(INDUCES)		2855904; 5769	90	20	90		
PLCG1	Carbohydrate Metabolism - inositol phosphate; EC 3.1.4.11; Motility/polarity/chemotaxis; Phospholipase	P10686	25738	Plcg1		rat	Y771	PHOSPHORYLATION	448575	IGTAEPDyGALYEGR		enzymatic activity, induced				760	12	30	546	Y771F mutation completely blocked activation while Y774F enhanced, and Y1253F inhibited full activation. 	
CDK11B	Apoptosis; EC 2.7.11.22; KINASE; Kinase, protein; Motility/polarity/chemotaxis; Protein kinase, CMGC; Protein kinase, Ser/Thr (non-receptor)	P21127	984	CDK11B	1p36.33	human	S115	PHOSPHORYLATION	455902	KRRHRSHsAEGGKHA		molecular association, regulation		14-3-3 beta(INDUCES); 14-3-3 theta(INDUCES); 14-3-3 epsilon(INDUCES); 14-3-3 gamma(INDUCES)		6354	1	2	1		
JAK2	EC 2.7.10.2; KINASE; Kinase, protein; Protein kinase, TK; Protein kinase, tyrosine (non-receptor)	Q62120	16452	Jak2		mouse	Y570	PHOSPHORYLATION	451494	VRREVGDyGQLHKTE	Pkinase_Tyr	enzymatic activity, inhibited				7601401; 8083; 3674	8	23	804		
TH iso4	Amino Acid Metabolism - tyrosine; EC 1.14.16.2; Endoplasmic reticulum; Mitochondrial; Oxidoreductase; Vesicle protein	P07101-4	7054	TH	11p15.5	human	S38	PHOSPHORYLATION	448545	RFIGRRQsLIEDARK	TOH_N	enzymatic activity, induced				7484	46	6	11		
PIP5K1C	Carbohydrate Metabolism - inositol phosphate; EC 2.7.1.68; Kinase, lipid; Motility/polarity/chemotaxis	O70161	18717	Pip5k1c		mouse	Y644	PHOSPHORYLATION	450241	TDERSWVySPLHYSA		molecular association, regulation; intracellular localization; enzymatic activity, induced	cytoskeletal reorganization	talin 1(INDUCES)		2949; 5239	4	0	0		
FcRL3	Adaptor/scaffold; Membrane protein, integral	Q96P31	115352	FCRL3	1q21-q22	human	Y662	PHOSPHORYLATION	469981	PGDSNPIySQIWSIQ		molecular association, regulation		ZAP70(INDUCES)		8823	1	0	0		
MARCKS	Actin binding protein; Motility/polarity/chemotaxis	P26645	17118	Marcks		mouse	S163	PHOSPHORYLATION	451837	SFKLSGFsFKKSKKE	MARCKS	intracellular localization	carcinogenesis, induced; cell motility, altered			15027801	8	41	78		
ANXA1	Calcium-binding protein; Lipid binding protein	P04083	301	ANXA1	9q21.13	human	S5	PHOSPHORYLATION	452051	___MAMVsEFLKQAW		molecular association, regulation; protein conformation		S100A11(DISRUPTS)		18410805	2	4	0	prevents the N-terminal peptide of ANXA1 from adopting an alpha-helical conformation 	
RASSF1 iso2	Tumor suppressor	Q9NS23-2	11186	RASSF1	3p21.3	human	S178	PHOSPHORYLATION	13258705	VRPVSVPsSKKPPSL		molecular association, regulation	apoptosis, inhibited	TRAIL-R1(DISRUPTS); 14-3-3 zeta(INDUCES); 14-3-3 epsilon(INDUCES); TNF-R1(DISRUPTS); MOAP1(DISRUPTS)		13159408	1	0	0		
NFAT2	DNA binding protein; Transcription factor	O95644	4772	NFATC1	18q23	human	S269	PHOSPHORYLATION	448862	PCNKRKYsLNGRQPP		intracellular localization; activity, inhibited; phosphorylation				2031; 4332502	2	1	1	phosphorylation creates predicted overlapping GSK3B phosphorylation sites	
IL-8R B	GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR; Receptor, cytokine	P25025	3579	CXCR2	2q35	human	S351	PHOSPHORYLATION	451047	SRPSFVGsSSGHTST		protein degradation; receptor desensitization, altered; receptor internalization, altered				3279	1	0	1		
Fyn	EC 2.7.10.2; KINASE; Kinase, protein; Protein kinase, TK; Protein kinase, tyrosine (non-receptor)	P39688	14360	Fyn		mouse	Y420	PHOSPHORYLATION	447882	RLIEDNEyTARQGAK	Pkinase_Tyr	enzymatic activity, induced				7400; 5422	19	55	3061		
Fe65	Adaptor/scaffold; Apoptosis; Transcription regulation	P46933	29722	Apbb1		rat	S611	PHOSPHORYLATION	2035401	ECRVRFLsFLAVGRD	PID	intracellular localization				1968366	1	0	0		
ROCK2	EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor)	Q62868	25537	Rock2		rat	T414	PHOSPHORYLATION	5931301	QLPFIGFtYFRENLL	Pkinase_C	enzymatic activity, inhibited				5930041	1	0	0	in vitro	
PKR	EC 2.7.10.2; EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor); Translation	P19525	5610	EIF2AK2	2p22-p21	human	T451	PHOSPHORYLATION	448089	KRTRSKGtLRYMSPE	Pkinase	enzymatic activity, induced				754; 755	4	1	0		
MAVS	Adaptor/scaffold; Membrane protein, integral	Q7Z434	57506	MAVS	20p13	human	S233	PHOSPHORYLATION	3204105	SFQPLARsTPRASRL		molecular association, regulation		PLK1(INDUCES)		9158111	1	1	0		
nicastrin	Membrane protein, integral	Q92542	23385	NCSTN	1q22-q23	human	S437	PHOSPHORYLATION	25533000	FLRARNIsGVVLADH	Nicastrin	protein degradation; molecular association, regulation				25347037	1	0	0	inhibits gamma-secretase complex formation	
TBX21	DNA binding protein; Transcription factor	Q9JKD8	57765	Tbx21		mouse	Y525	PHOSPHORYLATION	458297	KETEGQFyNYFPN__		molecular association, regulation	transcription, altered	GATA3(INDUCES)		7347	1	0	0		
Bcl-11B	C2H2-type zinc finger protein; Nuclear receptor co-regulator	Q99PV8	58208	Bcl11b		mouse	S381	PHOSPHORYLATION	4772890	SSTPPPVsPGRGNPM		molecular association, regulation		SENP1(INDUCES)		25573548	0	9	45		
HIPK2	EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, CMGC; Protein kinase, Ser/Thr (non-receptor)	Q9H2X6	28996	HIPK2	7q32-q34	human	K1191	UBIQUITINATION	3059901	GYPLSPAkVNQYPYI		protein degradation; ubiquitination				12662609; 2831762	2	0	0		
Tiam1	Guanine nucleotide exchange factor, Rac/Rho; Motility/polarity/chemotaxis	Q60610	21844	Tiam1		mouse	S60	PHOSPHORYLATION	11485305	EVSTRSSsTPSIPQS		protein degradation; molecular association, regulation		14-3-3 zeta(INDUCES)		11419330	1	0	0		
GAPDH	Carbohydrate Metabolism - glycolysis and gluconeogenesis; EC 1.2.1.12; EC 2.6.99.-; Oxidoreductase	P04406	2597	GAPDH	12p13	human	K251	ACETYLATION	14791500	DLTCRLEkPAKYDDI	Gp_dh_C	intracellular localization				14772324	1	0	0	nuclear translocation	
Trad	EC 2.7.11.1; Guanine nucleotide exchange factor, Rac/Rho; KINASE; Kinase, protein; Protein kinase, CAMK; Protein kinase, Ser/Thr (non-receptor)	A2CG49	545156	Kalrn		mouse	T1572	PHOSPHORYLATION	3363402	EPIQLPKtPAKLRNN		enzymatic activity, induced	cytoskeletal reorganization			3301236	1	0	1		
CDK5R1	Protein kinase, regulatory subunit	P61810	116671	Cdk5r1		rat	T138	PHOSPHORYLATION	471393	PAITSAGtPKRVIVQ	CDK5_activator	protein stabilization				9104	6	0	0	decreased phosphorylation in adult compared to prenatal brain correlated with lower resistance to calpain cleavage	
AMPKA1	Autophagy; EC 2.7.1.-; EC 2.7.11.1; EC 2.7.11.26; KINASE; Kinase, protein; Protein kinase, CAMK; Protein kinase, Ser/Thr (non-receptor)	P54645	65248	Prkaa1		rat	T183	PHOSPHORYLATION	448786	SDGEFLRtSCGSPNY	Pkinase	protein stabilization; molecular association, regulation; enzymatic activity, induced		14-3-3 sigma(INDUCES); 14-3-3 beta(INDUCES); 14-3-3 theta(INDUCES); 14-3-3 zeta(INDUCES); 14-3-3 epsilon(INDUCES); 14-3-3 gamma(INDUCES); 14-3-3 eta(INDUCES)		1173015; 9086; 2995; 1678; 5904; 2701901; 451; 13852003; 1173030	154	11	19		
MYH14	Motility/polarity/chemotaxis; Motor protein	Q6URW6	71960	Myh14		mouse	T1960	PHOSPHORYLATION	27623909	PLTFTTRtVRQVFRL			cytoskeletal reorganization			27619342	0	0	0	Phosphorylation of either residue abolishes filament assembly of MYH14 Rod1296-1854.	
ADCY6	Adenylyl cyclase; EC 4.6.1.1; Lyase; Membrane protein, integral; Membrane protein, multi-pass; Nucleotide Metabolism - purine	AAA40678	25289	Adcy6		rat	S608	PHOSPHORYLATION	467271	AFSRTKDsKAFRQMG	DUF1053	enzymatic activity, induced				8212	1	0	0		
C/EBP-alpha	DNA binding protein; Transcription factor	P53566	12606	Cebpa		mouse	S21	PHOSPHORYLATION	448308	PMSSHLQsPPHAPSN		activity, induced	transcription, altered			4313609	7	0	0	impaired glucose uptake and Glut 4 expression 	
GTF2I	DNA binding protein; Transcription, coactivator/corepressor	P78347	2969	GTF2I	7q11.23	human	S784	PHOSPHORYLATION	457075	GVPFRRPsTFGIPRL	GTF2I		transcription, induced			8844	2	5	264		
Jun	Transcription factor	P05412	3725	JUN	1p32-p31	human	T286	PHOSPHORYLATION	17737605	RLEEKVKtLKAQNSE	DUF3450; HAP1_N; Jnk-SapK_ap_N; Seryl_tRNA_N; bZIP_1; PspA_IM30; DUF904; FlaC_arch; TMF_DNA_bd		carcinogenesis, altered; cell growth, altered			17675043	1	0	1		
NKX2-1	DNA binding protein; Transcription factor	P23441	25628	Nkx2-1		rat	T9	PHOSPHORYLATION	451108	SMSPKHTtPFSVSDI			transcription, induced			3308	2	0	0	T9A mutation reduced transactivation of the surfactant B gene promoter	
SMC3	Cell cycle regulation; DNA repair	Q9UQE7	9126	SMC3	10q25	human	S1083	PHOSPHORYLATION	453061	ESERGSGsQSSVPSV	SMC_N		cell cycle regulation			3301215	3	8	3	required for intra-S phase checkpoint	
p90RSK	EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor); Translation	Q15418	6195	RPS6KA1	1p	human	S363	PHOSPHORYLATION	447989	TSRTPKDsPGIPPSA	Pkinase_C	enzymatic activity, induced				30280007	36	20	4		
BRCA1	EC 6.3.2.-; Nuclear receptor co-regulator; Transcription, coactivator/corepressor; Tumor suppressor; UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase	P38398	672	BRCA1	17q21	human	S694	PHOSPHORYLATION	4787521	QTSKRHDsDTFPELK	EIN3	protein stabilization				12558736	1	9	3		
CCDC124		Q96CT7	115098	CCDC124	19p13.11	human	S122	PHOSPHORYLATION	27445755	DTAEKAKsHLEVPLE	DUF1014	protein stabilization				28722412	1	1	0		
ADRA1B	GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR	P18841		ADRA1B		hamster	S404	PHOSPHORYLATION	451004	RSQSRKDsLDDSGSC		receptor desensitization, altered				3257	1	5	3		
ROMK	Channel, potassium; Membrane protein, integral; Membrane protein, multi-pass	P48048	3758	KCNJ1	11q24	human	Y337	PHOSPHORYLATION	451246	SKTKEGKyRVDFHNF	IRK	intracellular localization; activity, inhibited				8784; 9980400; 3468	4	0	0		
NHERF	Adaptor/scaffold; Motility/polarity/chemotaxis	O14745	9368	SLC9A3R1	17q25.1	human	T95	PHOSPHORYLATION	4047202	LLVVDPEtDEQLQKL	DUF1537	phosphorylation				14780509	2	0	0	facilitates phosphorylation of S77	
SHP-1	EC 3.1.3.48; Motility/polarity/chemotaxis; PHOSPHATASE; Protein phosphatase, tyrosine (non-receptor)	P29351	15170	Ptpn6		mouse	S591	PHOSPHORYLATION	454019	DKEKNKGsLKRK___		protein processing; intracellular localization; enzymatic activity, inhibited				4338210; 13354732; 11973	5	1	15		
Nur77	Apoptosis; DNA binding protein; Nuclear receptor	P22736	3164	NR4A1	12q13	human	S140	PHOSPHORYLATION	2591500	GSPCSAPsPSTPSFQ		molecular association, regulation	cell cycle regulation	Pin1(INDUCES)		21683712	3	0	0	required for cell proliferation; interaction with Pin1 enhances Nur77 ability to interact with p300	
calmodulin	Calcium-binding protein	P62158	801	CALM1	14q32.11	human	S82	PHOSPHORYLATION	448705	RKMKDTDsEEEIREA	DUF2267; DUF1103; LNS2; TerB; Tenui_NCP	protein conformation				9156; 8314	5	6	0		
ITGB1	Cell adhesion; Cell surface; Membrane protein, integral; Motility/polarity/chemotaxis; Receptor, misc.	P05556	3688	ITGB1	10p11.2	human	S785	PHOSPHORYLATION	452040	GENPIYKsAVTTVVN	Integrin_b_cyt		cytoskeletal reorganization			15754905	5	4	16		
MafA	DNA binding protein; Transcription factor	Q8CF90	378435	Mafa		mouse	S65	PHOSPHORYLATION	5403102	PCSSVPSsPSFCAPS		protein degradation; molecular association, regulation; ubiquitination; phosphorylation	transcription, induced	MafA(INDUCES)	DNA(NOT_REPORTED)	5354437; 13326312	5	0	0	 ; stimulates phosphorylation of other residues	
DLG1	Adaptor/scaffold; Motility/polarity/chemotaxis	Q12959	1739	DLG1	3q29	human	S443	PHOSPHORYLATION	5931300	FLGQTPAsPARYSPV	PDZ_assoc	protein degradation; protein stabilization; ubiquitination; intracellular localization				7549222; 5930023	2	0	9	degraded by HPV E6 oncoprotein in HPV-containing cell lines	
Mnk1 iso2	EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, CAMK; Protein kinase, Ser/Thr (non-receptor); Translation	Q9BUB5-2	8569	MKNK1	1p33	human	T214	PHOSPHORYLATION	447622	ITTPELTtPCGSAEY	Pkinase	intracellular localization; enzymatic activity, induced				762706	11	0	0	Leaves nucleus to cytoplasm upon phosphorylation.	
BRF1	Transcription factor	Q07352	677	ZFP36L1	14q22-q24	human	S92	PHOSPHORYLATION	470147	RFRDRSFsEGGERLL	Tis11B_N	protein stabilization; molecular association, regulation; intracellular localization	transcription, altered; RNA stability, altered	14-3-3 beta(INDUCES)		4295; 9014; 2451820	3	5	1	for its physiological effect phosphorylation of this site cooperates with phosphorylation of S90 and S203; inhibits BRF1-dependent AMD ( ARE-mediated mRNA decay)	
p53	Activator protein; DNA binding protein; Motility/polarity/chemotaxis; Nuclear receptor co-regulator; Transcription factor; Tumor suppressor	P04637	7157	TP53	17p13.1	human	S46	PHOSPHORYLATION	447536	AMDDLMLsPDDIEQW		activity, induced; molecular association, regulation	apoptosis, altered; apoptosis, induced; apoptosis, inhibited; transcription, induced; transcription, altered; cell growth, altered	TFB1M(INDUCES); GTF2H1(NOT_REPORTED); CBP(INDUCES); GTF2H1(INDUCES); Pin1(INDUCES)		2435; 5197; 1968315; 2665605; 2422202; 2745101; 26341714; 13361600; 1919608; 18378508; 23013822; 6136; 6134; 12662609; 2856305; 6131; 731; 6045; 11387204; 4214803; 1962900; 8071; 5316; 7423	82	2	0		
14-3-3 epsilon	Adaptor/scaffold	P62258	7531	YWHAE	17p13.3	human	K123	ACETYLATION	11315832	ESKVFYYkMKGDYHR	14-3-3	molecular association, regulation		SF2(DISRUPTS); TSC22D1(DISRUPTS); SFRS6(DISRUPTS); PLEKHQ1(DISRUPTS); Gab2(DISRUPTS); RAF1(DISRUPTS); Dok3(DISRUPTS); SFRS4(DISRUPTS); VASP(DISRUPTS); HDAC4(DISRUPTS); TSC2(DISRUPTS); SFRS10(DISRUPTS); LARP(DISRUPTS); ARAF(DISRUPTS); GBF1(DISRUPTS); SRm300(DISRUPTS)		8156721	0	1	0		
FAK	EC 2.7.1.112; EC 2.7.10.2; KINASE; Kinase, protein; Protein kinase, TK; Protein kinase, tyrosine (non-receptor)	P34152	14083	Ptk2		mouse	S770	PHOSPHORYLATION	450196	SSEGFYPsPQHMVQT		molecular association, regulation	cell cycle regulation; cell differentiation, altered; carcinogenesis, induced; cell growth, altered	DNAI1(INDUCES)		9401430	5	1	0	S770 FAK phosphorylation regulates centrosomes during mitosis, proliferation, tublogenesis, and tumor angiogenesis.	
cortactin	Actin binding protein; Cytoskeletal protein; Motility/polarity/chemotaxis	Q60598	13043	Cttn		mouse	Y421	PHOSPHORYLATION	447702	RPPSSPIyEDAAPFK		molecular association, regulation	cell cycle regulation; cell motility, induced; cell motility, altered; cytoskeletal reorganization	smMLCK(INDUCES); N-WASP(INDUCES)		3904; 25712657; 8392; 2790302; 11502	26	45	713	Tyr to Phe mutation of this site prevents FAK-mediated FA turnover	
FGFR1	EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Protein kinase, TK; Protein kinase, tyrosine (receptor)	P16092	14182	Fgfr1		mouse	Y766	PHOSPHORYLATION	447922	ALTSNQEyLDLSIPL		molecular association, regulation	cell cycle regulation; transcription, altered; cell growth, altered	Shb(INDUCES)		5937; 7397646	8	0	0	Y766F mutation causes embryonic transformations in vertebral column.	
tau iso8	Cytoskeletal protein	P10636-8	4137	MAPT	17q21.1	human	S320	PHOSPHORYLATION	450139	VDLSKVTsKCGSLGN	Tubulin-binding	protein stabilization	cytoskeletal reorganization			10303912; 4418	3	0	0		
Akt1	EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor)	P31749	207	AKT1	14q32.32	human	S124	PHOSPHORYLATION	450018	EMDFRSGsPSDNSGA		enzymatic activity, induced				8911	4	7	0	S124 and T450 have minor effects on enzyme activation;  T308 and S473 have major effects.	
Ku70	DNA binding protein; DNA repair; EC 3.6.4.-; EC 4.2.99.-; Helicase	P12956	2547	XRCC6	22q13.2	human	S155	PHOSPHORYLATION	21691607	WVCANLFsDVQFKMS	Ku_N	phosphorylation	apoptosis, induced			21683703	1	0	0	mutation S155A enhances cell survival; Ku70 S155D mutation enhances ATF2 phosphorylation	
P2Y2	GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR; Receptor, misc.	P41231	5029	P2RY2	11q13.5-q14.1	human	S243	PHOSPHORYLATION	2909200	LPRAKRKsVRTIAVV	7tm_1; Sigma_reg_N	receptor desensitization, altered; intracellular localization				8702	1	0	0		
FANCD2	DNA repair	Q9BXW9	2177	FANCD2	3p26	human	S717	PHOSPHORYLATION	453231	KDGGPVTsQESGQKL		activity, induced	cell cycle regulation			8943	1	6	0	promotes monoubiquitination of FANCD2	
NFM	Cytoskeletal protein	P08553	18040	Nefm		mouse	S605	PHOSPHORYLATION	451836	EKPEKAKsPMPKSPV			cytoskeletal reorganization			7072905	4	11	8	slightly altered axoplasmic organization in 7S/A mice mutant	
PXN	Adaptor/scaffold; Cell adhesion; Cytoskeletal protein; Motility/polarity/chemotaxis	P49024	395832	PXN		chicken	S457	PHOSPHORYLATION	448768	AILENYIsALNTLWH	LIM	intracellular localization				1936	1	0	0		
eNOS	Amino Acid Metabolism - arginine and proline; EC 1.14.13.39; Oxidoreductase	P70313	18127	Nos3		mouse	S1178	PHOSPHORYLATION	467802	RIRTQSFsLQERQLR		intracellular localization				3394318	7	5	1	S1177 appears in cell membranes and perinuclear golgi and significant difference of protein expression between the LC and GC regions of aorta ascending archplate.	
BKR2	GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR	P30411	624	BDKRB2	14q32.1-q32.2	human	Y177	PHOSPHORYLATION	457134	GVRWAKLySLVIWGC	7tm_1; TM	activity, induced; phosphorylation				6971	1	0	1	 this increases ERK activation when stimulated with EGF+isoproterenol+bradykinin as compared to the WT BKR2.; Mutation of both tyrosines to phenylalanines prevents Gi protein-mediated cAMP accumulation induced by bradykinin	
C/EBP-alpha	DNA binding protein; Transcription factor	P05554	24252	Cebpa		rat	S230	PHOSPHORYLATION	447618	PPPTPVPsPHPAPAM		activity, inhibited	transcription, altered			7862	4	0	0	In 3T3L1 preadipocytes, mutation of T222/T226 to alanines increased transcription at CBE-containing promoter (as compared to WT C/EBP-alpha).  S230A had a similar effect as the double T->A mutation.  The triple alanine mutation had the highest transcription of the reporter gene.  S230A did not reduce T222/226 phosphorylation (although CHIR99021 inhibitor did).	
cortactin	Actin binding protein; Cytoskeletal protein; Motility/polarity/chemotaxis	Q14247	2017	CTTN	11q13	human	Y470	PHOSPHORYLATION	447703	AYATEAVyESAEAPG		molecular association, regulation	cytoskeletal reorganization			3902; 1039	16	3	10	Tyrosine phosphorylation  is necessary for enhanced S1P barrier enhancement.   ; Previous work by the authors showed that src attenuates the actin cross-linking activity of cortactin.  These studies show that transfection with a cortactin mutant (F421/F470/F486) impairs the motility of endothelial cells.	
PPP1R14A	Inhibitor protein; Protein phosphatase, regulatory subunit	Q96A00	94274	PPP1R14A	19q13.1	human	T38	PHOSPHORYLATION	449098	QKRHARVtVKYDRRE	PP1_inhibitor	receptor desensitization, altered; activity, inhibited	cell motility, altered			3049; 2425	26	0	0	inhibition of MLCP activity, activates contractile response in arterial smooth muscle; Phosphorylation at T38-CPI-17 was required for induction of cerebellar long-term synaptic depression	
Bak1	Apoptosis; Endoplasmic reticulum; Membrane protein, integral; Mitochondrial	Q16611	578	BAK1	6p21.3	human	Y108	PHOSPHORYLATION	15794303	QPTAENAyEYFTKIA	Bcl-2	protein conformation; activity, inhibited	apoptosis, altered			15755117	3	1	0		
CENTG1 iso2	GTPase activating protein, ARF; Motility/polarity/chemotaxis	Q99490-2	116986	AGAP2	12q14.1	human	Y682	PHOSPHORYLATION	467224	ESWIRAKyEQLLFLA	ArfGap	protein stabilization	apoptosis, altered			8133	1	0	0		
TRIP10 iso3	Adaptor/scaffold; Motility/polarity/chemotaxis; Nuclear receptor co-regulator	Q15642-3	9322	TRIP10	19p13.3	human	Y471	PHOSPHORYLATION	480709	ESQDTPIyTEFDEDF		intracellular localization	carcinogenesis, altered; cytoskeletal reorganization			18837553	1	0	2	alters TRIP10 invadopodia-suppressive activity	
NuaK1	EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, CAMK; Protein kinase, Ser/Thr (non-receptor)	O60285	9891	NUAK1	12q23.3	human	T211	PHOSPHORYLATION	456032	QKDKFLQtFCGSPLY	Pkinase	enzymatic activity, induced	cell cycle regulation; cell growth, inhibited; cell growth, altered			7692; 12525206; 19016925	5	1	0		
TTK	Cancer Testis Antigen (CTA); EC 2.7.12.1; KINASE; Kinase, protein; Protein kinase, Other; Protein kinase, dual-specificity	P33981	7272	TTK	6q13-q21	human	T12	PHOSPHORYLATION	13194901	DLSGRELtIDSIMNK		intracellular localization				13164217	2	1	1	regulates kinetochore localization of TTK	
ATRIP	Cell cycle regulation; DNA binding protein; DNA repair	Q8WXE1	84126	ATRIP	3p21.31	human	S224	PHOSPHORYLATION	485778	APSVSHVsPRKNPSV			cell cycle regulation			12094	1	14	5	important for the G2-M checkpoint arrest in response to DNA damage	
Cdc25B	EC 3.1.3.48; Motility/polarity/chemotaxis; Nuclear receptor co-regulator; PHOSPHATASE; Protein phosphatase, dual-specificity	P30306	12531	Cdc25b		mouse	S321	PHOSPHORYLATION	448409	QRLFRSPsMPCSVIR	M-inducer_phosp	intracellular localization	cell cycle regulation			23260311; 18021017	11	3	23		
EphA3	EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Protein kinase, TK; Protein kinase, tyrosine (receptor)	P29320	2042	EPHA3	3p11.2	human	Y602	PHOSPHORYLATION	449913	TYVDPHTyEDPTQAV		molecular association, regulation; enzymatic activity, induced	cytoskeletal reorganization; cell adhesion, altered	Crk(INDUCES)		25779406; 2462	3	6	44		
CACNB2	Channel, calcium	P54288	100009277	CAB2		rabbit	S522	PHOSPHORYLATION	486359	SGTSRGLsRQETFDS		activity, inhibited				12091; 15785202	3	3	5		
AML3	DNA binding protein; Transcription factor	Q13950	860	RUNX2	6p21	human	S196	PHOSPHORYLATION	27728401	GRSGRGKsFTLTITV	Runt	molecular association, regulation	transcription, induced		DNA(INDUCES)	27623402	1	0	0	induction of MMP3 and MMP9 transcription, invasion of breast cancer cells	
CRMP-1	Cell development/differentiation; Cytoskeletal protein; Hydrolase	Q14194	1400	CRMP1	4p16.1	human	T509	PHOSPHORYLATION	454314	PVYEVPAtPKYATPA			cytoskeletal reorganization			1172844	5	13	7	Phosphorylation induces  increased density of synaptic clusters and neurite projection.  	
NEDD1	Cell cycle regulation	Q8NHV4	121441	NEDD1	12q23.1	human	S426	PHOSPHORYLATION	9379002	VNKGSDEsIGKGDGF		molecular association, regulation	cell cycle regulation			9201031	1	1	0	important for binding of NEDD1 with gamma-tubulin	
MCM3	DNA replication; EC 3.6.4.12	P25206	17215	Mcm3		mouse	S725	PHOSPHORYLATION	475061	HTPKTDDsQEKTDDS	CPSF100_C	intracellular localization				9265	1	3	0	Preferentially localized to the soluble nucleoplasmic fraction.	
TDP43	RNA binding protein	Q921F2	230908	Tardbp		mouse	S409	PHOSPHORYLATION	3084616	GSSMDSKsSGWGM__		ubiquitination				28722194	18	0	0	Phosphorylated, ubiqitinated protein forms insoluble aggregates.	
SLBP	RNA binding protein	Q14493	7884	SLBP	4p16.3	human	T171	PHOSPHORYLATION	11003653	QPGIHPKtPNKFKKY	Ebola_NP	molecular association, regulation		SLBP(DISRUPTS)	RNA(INDUCES)	27565308	0	3	20		
SP1	C2H2-type zinc finger protein; DNA binding protein; Transcription factor	P08047	6667	SP1	12q13.1	human	S7	PHOSPHORYLATION	2535902	_MSDQDHsMDEMTAV		protein degradation				2425224	1	7	0		
RhoGDI beta	Cell adhesion; G protein regulator, misc.; Motility/polarity/chemotaxis	P52566	397	ARHGDIB	12p12.3	human	S31	PHOSPHORYLATION	4933709	YKPPPQKsLKELQEM	Rho_GDI	molecular association, regulation; activity, inhibited		RAC1(DISRUPTS)		25227619	1	1	31	impaired GDI2 function	
KCC2	Membrane protein, integral; Membrane protein, multi-pass; Transporter	Q91V14	57138	Slc12a5		mouse	Y1109	PHOSPHORYLATION	3087801	NRNGDENyMEFLEVL		protein degradation				14790321	3	0	0	decreases the cell surface stability of SLC12A5 (aka KCC2)	
IRS1	Adaptor/scaffold; Motility/polarity/chemotaxis	P35570	25467	Irs1		rat	S635	PHOSPHORYLATION	447507	YMPMSPKsVSAPQQI		molecular association, regulation		PIK3R1(DISRUPTS)		1903000	27	3	0		
Bim	Apoptosis	O43521	10018	BCL2L11	2q13	human	S69	PHOSPHORYLATION	449330	GPLAPPAsPGPFATR		protein degradation; molecular association, regulation	apoptosis, altered; apoptosis, inhibited; cell adhesion, altered; transcription, altered	Bcl-xL(DISRUPTS); MCL1(DISRUPTS)		4214815; 1173005; 6164; 5694	18	0	1		
MSK1	EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor)	O75582	9252	RPS6KA5	14q31-q32.1	human	S212	PHOSPHORYLATION	448214	DETERAYsFCGTIEY	Pkinase	enzymatic activity, induced				6119	2	3	8		
amphiphysin	Vesicle protein	P49418	273	AMPH	7p14-p13	human	T350	PHOSPHORYLATION	469996	PEVKKEEtLLDLDFD		molecular association, regulation		CLTC(DISRUPTS)		8948	1	0	0		
MARK2	EC 2.7.11.1; EC 2.7.11.26; KINASE; Kinase, protein; Protein kinase, CAMK; Protein kinase, Ser/Thr (non-receptor)	CAB06295	60328	Mark2		rat	S92	PHOSPHORYLATION	26573804	DKTQLNSsSLQKLFR	Pkinase		cytoskeletal reorganization			25785412	1	0	0	neurite outgrowth	
caldesmon	Actin binding protein	P12957	373965	CALD1		chicken	S635	PHOSPHORYLATION	457432	AVVSKIDsRLEQYTS	Caldesmon	molecular association, regulation		caldesmon(DISRUPTS)		15571612	1	3	0	enhances effect of S672 and S702  phosphorylation to weaken interaction	
ITGB1	Cell adhesion; Cell surface; Membrane protein, integral; Motility/polarity/chemotaxis; Receptor, misc.	P07228	374058	ITGB1		chicken	S790	PHOSPHORYLATION	452040	GENPIYKsAVTTVVN	Integrin_b_cyt		cell motility, altered; cell adhesion, altered			6254	5	4	16		
GIT2	GTPase activating protein, ARF; Motility/polarity/chemotaxis	Q9Y621	374035	GIT2		chicken	Y286	PHOSPHORYLATION	456753	EELAMYVyDEVDRRE	DUF4319; GIT_SHD	molecular association, regulation; intracellular localization	cell adhesion, altered	PXN(INDUCES)		6868	1	0	0		
N-WASP	Adaptor/scaffold; Motility/polarity/chemotaxis	Q91YD9	73178	Wasl		mouse	Y253	PHOSPHORYLATION	450253	RETSKVIyDFIEKTG	PBD	molecular association, regulation; intracellular localization		KPNA1(DISRUPTS)		2956	7	36	1347	Phosphorylation of Y253 plays an important role in promoting cell migration, and reduces N-WASP interaction with importin alpha S1 (NPI-1). 	
TRPV1	Channel, cation; Membrane protein, integral; Membrane protein, multi-pass; Receptor, misc.	O35433	83810	Trpv1		rat	T704	PHOSPHORYLATION	487542	WKLQRAItILDTEKS		activity, induced; receptor desensitization, altered		RNUXA(INDUCES)		12256; 8871; 12482281	4	0	0		
Myf-6	DNA binding protein; Transcription factor	P15375	17878	Myf6		mouse	S31	PHOSPHORYLATION	2907504	PLEVAEGsPLYPGSD	Basic		cell differentiation, altered; transcription, inhibited			8651	1	0	0		
TAK1	EC 2.7.11.25; KINASE; Kinase, protein; Protein kinase, Ser/Thr (non-receptor); Protein kinase, TKL	O43318	6885	MAP3K7	6q15	human	T184	PHOSPHORYLATION	454876	GTACDIQtHMTNNKG	Pkinase_Tyr	phosphorylation; enzymatic activity, induced				3301224; 14780521; 4448	8	0	0	required for the IL-1beta-induced activation of IKK-NFkB and JNK-AP1 and production of IL-6; in vitro assay; promotes TAK1 activity , but not mandatory	
PDE4C iso2	EC 3.1.4.17; Nucleotide Metabolism - purine; Phosphodiesterase	Q08493-2	5143	PDE4C	19p13.11	human	S13	PHOSPHORYLATION	458390	PHSQRREsFLYRSDS		enzymatic activity, induced				7471	1	7	0		
CREB	DNA binding protein; Transcription factor	P15337	81646	Creb1		rat	S114	PHOSPHORYLATION	451809	ESEDSQEsVDSVTDS	pKID		transcription, altered			3932	7	0	1		
endophilin 1	Adaptor/scaffold; Membrane protein, peripheral; Vesicle protein	Q99962	6456	SH3GL2	9p22	human	T14	PHOSPHORYLATION	457634	KKQFHKAtQKVSEKV	BAR	molecular association, regulation		CIN85(DISRUPTS)		6985	1	0	0		
PKCD	EC 2.7.10.2; EC 2.7.11.13; KINASE; Kinase, protein; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor)	Q05655	5580	PRKCD	3p21.31	human	Y334	PHOSPHORYLATION	450077	MQDNSGTyGKIWEGS		molecular association, regulation	apoptosis, induced	Src(INDUCES)		12011	12	13	543	Y334 phosphorylation increases clevage of PKCD into active catalytic domain. 	
HDAC4	DEACETYLASE; Deacetylase; EC 3.5.1.98; Hydrolase; Nuclear receptor co-regulator	P56524	9759	HDAC4	2q37.3	human	S467	PHOSPHORYLATION	448489	RPLGRTQsAPLPQNA		molecular association, regulation; intracellular localization	transcription, altered	14-3-3 beta(INDUCES); 14-3-3 epsilon(INDUCES)		2586; 1116	2	5	19		
PCNT	Cell cycle regulation	O95613	5116	PCNT	21q22.3	human	S1235	PHOSPHORYLATION	25617500	MSSVAEIsSHMRESF			cytoskeletal reorganization			25617200	1	0	0	important for spindle formation and centrosomal microtubule nucleation and the recruitment of the PCM proteins for centrosome maturation in mitosis	
calponin 1	Actin binding protein; Contractile protein; Motility/polarity/chemotaxis; Myosin binding protein	P26932	396522	CNN1		chicken	T259	PHOSPHORYLATION	469596	GASQQGMtVYGLPRQ	Calponin	molecular association, regulation		ACTA1(DISRUPTS)		8316	1	1	0	f-actin (rabbit skeletal muscle) shown by co-sedimentation	
TH iso3	Amino Acid Metabolism - tyrosine; EC 1.14.16.2; Endoplasmic reticulum; Mitochondrial; Oxidoreductase; Vesicle protein	P07101-3	7054	TH	11p15.5	human	S19	PHOSPHORYLATION	448542	KGFRRAVsELDAKQA	TOH_N	molecular association, regulation		14-3-3 zeta(INDUCES); 14-3-3 gamma(INDUCES)		11189903; 10167105	33	4	3	a ternary complex between S19-phosphorylated TH, 14-3-3 proteins and membranes 	
TRPV5	Channel, cation; Membrane protein, integral; Membrane protein, multi-pass; Motility/polarity/chemotaxis	Q9NQA5	56302	TRPV5	7q35	human	S144	PHOSPHORYLATION	27115700	LTRRASVsARATGTA	Ank_2	activity, inhibited				27108302	1	0	0	S144 phosphorylation is necessary for plasmin inhibition of channel Ca++ currents. 	
ANKRD2	Contractile protein	Q9WV06	56642	Ankrd2		mouse	S68	PHOSPHORYLATION	480101	QERVRKTsLDLRREI			cell differentiation, inhibited			20755815	1	4	8	inhibits muscle differentiation	
SKP2	Ubiquitin conjugating system	Q13309	6502	SKP2	5p13	human	T417	PHOSPHORYLATION	15165300	WGIKCRLtLQKPSCL		activity, induced; protein stabilization; ubiquitination	cell cycle regulation			15022729	1	0	0		
BRCA1	EC 6.3.2.-; Nuclear receptor co-regulator; Transcription, coactivator/corepressor; Tumor suppressor; UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase	P38398	672	BRCA1	17q21	human	S1524	PHOSPHORYLATION	448038	LQNRNYPsQEELIKV		molecular association, regulation; phosphorylation	cell cycle regulation	ATM(INDUCES); claspin(INDUCES)		1757; 5337; 5260; 3567	8	8	2		
Cdc6	Cell cycle regulation	Q99741	990	CDC6	17q21.3	human	T37	PHOSPHORYLATION	17481900	SDAKLEPtNVQTVTC		molecular association, regulation	cell cycle regulation	CDK1(INDUCES)		17431514	1	0	0		
HER3	EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Protein kinase, TK; Protein kinase, tyrosine (receptor)	P21860	2065	ERBB3	12q13	human	Y1197	PHOSPHORYLATION	448640	EEDEDEEyEYMNRRR		molecular association, regulation		GRB7(INDUCES); Grb2(INDUCES)		10144208	5	1	23	Grb2 binding is reduced campared with Grb7.	
CK1E	EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, CK1; Protein kinase, Ser/Thr (non-receptor)	P49674	1454	CSNK1E	22q13.1	human	S408	PHOSPHORYLATION	453421	RIPASQTsVPFDHLG		enzymatic activity, inhibited				8419; 2331	2	7	10	some subset of these 8 sites	
PCSK9	Cell development/differentiation; EC 3.4.21.-; Protease; Secreted; Secreted, signal peptide	Q8NBP7	255738	PCSK9	1p32.3	human	S47	PHOSPHORYLATION	2811403	ELVLALRsEEDGLAE		protein processing				2807224	1	2	0	stabilizes against cleavage of propeptide	
WAVE2	Actin binding protein; Motility/polarity/chemotaxis	Q9Y6W5	10163	WASF2	1p36.11	human	S484	PHOSPHORYLATION	6377638	IAVEYSDsEDDSSEF		activity, inhibited	cytoskeletal reorganization			6337810	1	0	1		
Syk	EC 2.7.10.2; KINASE; Kinase, protein; Protein kinase, TK; Protein kinase, tyrosine (non-receptor)	P48025	20963	Syk		mouse	S291	PHOSPHORYLATION	1983707	ISRIKSYsFPKPGHK		molecular association, regulation		PHB(INDUCES)		15755119	2	3	26		
BTG2	Transcription factor	Q04211	12227	Btg2		mouse	S147	PHOSPHORYLATION	455911	QMMLGRSsPSKNYVM		molecular association, regulation		Pin1(INDUCES)		6346	1	0	0		
BRIP1	EC 3.6.1.-; EC 3.6.4.13; Helicase	Q9BX63	83990	BRIP1	17q22.2	human	T1133	PHOSPHORYLATION	5831623	EDESIYFtPELYDPE		molecular association, regulation	cell cycle regulation	TOPBP1(INDUCES)		12778815	1	0	1		
N-CoR1	Nuclear receptor co-regulator; Transcription, coactivator/corepressor	O75376	9611	NCOR1	17p11.2	human	S70	PHOSPHORYLATION	3828921	QQLRRRPsLLSEFHP		intracellular localization	transcription, inhibited	AR(INDUCES)		27258207	1	5	66	increases nuclear translocation, inhibits transcription of PSA and NKX3.1	
NFL	Cytoskeletal protein	P07196	4747	NEFL	8p21	human	T21	PHOSPHORYLATION	2872004	YKRRYVEtPRVHISS	Filament_head	molecular association, regulation		NFL(DISRUPTS)		2865409	1	0	0		
lamin A/C	Cytoskeletal protein	P02545	4000	LMNA	1q22	human	S403	PHOSPHORYLATION	456874	QRSRGRAsSHSSQTQ	DUF3584	intracellular localization				7523	1	14	73	nuclear transport of lamin	
NDEL1	Microtubule binding protein; Protease	Q9GZM8	81565	NDEL1	17p13.1	human	S242	PHOSPHORYLATION	3685801	IPNGFGTsPLTPSAR	NUDE_C	molecular association, regulation; intracellular localization		PAFAH1B1(INDUCES)		9081	2	2	1		
BRCA1	EC 6.3.2.-; Nuclear receptor co-regulator; Transcription, coactivator/corepressor; Tumor suppressor; UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase	P38398	672	BRCA1	17q21	human	S1387	PHOSPHORYLATION	455495	EDCSGLSsQSDILTT			cell cycle regulation			5337	6	0	0	mutation of S1387 abrogates radiation-induced S-phase arrest, but does not affect the G2-M checkpoint. 	
NFAT1	DNA binding protein; Transcription factor	Q60591	18019	Nfatc2		mouse	S270	PHOSPHORYLATION	447849	VAPLPAAsPQRSRSP			transcription, inhibited			1188	0	4	0		
DUPD1	EC 3.1.3.16; EC 3.1.3.48; PHOSPHATASE; Protein phosphatase, dual-specificity	P0C595		Dupd1		rat	T155	PHOSPHORYLATION	18122802	MGRSRSAtLVLAYLM	DSPc	enzymatic activity, inhibited				18021008	1	0	0		
PAK5	EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, STE; Protein kinase, Ser/Thr (non-receptor)	Q9P286	57144	PAK7	20p12	human	S573	PHOSPHORYLATION	11327000	HRDIKSDsILLTSDG	Pkinase		cytoskeletal reorganization			10292916	1	0	0		
GFAP	Cytoskeletal protein	P14136	2670	GFAP	17q21	human	S17	PHOSPHORYLATION	449620	ARRSYVSsGEMMVGG	Filament_head	protein stabilization				2254	1	1	0		
GPR15	GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR	P49685	2838	GPR15	3q11.2-q13.1	human	S359	PHOSPHORYLATION	17737600	RRRKRSVsL______		molecular association, regulation; protein processing; intracellular localization		14-3-3 beta(INDUCES); COPB1(DISRUPTS)		17675036	1	0	0		
perilipin	Lipid binding protein	Q8CGN5	103968	Plin1		mouse	S276	PHOSPHORYLATION	450081	QVVSRRQsEVRVPWL	Perilipin; Rep_4; RXT2_N	molecular association, regulation		HSL(INDUCES)		11424203	2	0	0		
CTNNB1	Actin binding protein; Cell adhesion; Motility/polarity/chemotaxis; Nuclear receptor co-regulator; Transcription factor	Q9WU82	84353	Ctnnb1		rat	Y654	PHOSPHORYLATION	447585	RNEGVATyAAAVLFR	Arm	intracellular localization				5865	14	3	21		
EGR1	C2H2-type zinc finger protein; DNA binding protein; Transcription factor	P18146	1958	EGR1	5q31.1	human	S378	PHOSPHORYLATION	11421601	RICMRNFsRSDHLTT	zf-UBR; zf-H2C2_2		transcription, altered		DNA(DISRUPTS)	10274604	1	0	0		
p21Cip1	Cell cycle regulation; Inhibitor protein	P38936	1026	CDKN1A	6p21.2	human	S153	PHOSPHORYLATION	456134	SMTDFYHsKRRLIFS		molecular association, regulation; intracellular localization		calmodulin(DISRUPTS)		7124; 6608	2	0	0	S152 D mutation inhibts binding of CaM to p21. S152D disrupted stress fibers. Phosphorylation at S152 did not affect p21 binding to PCNA. ; Mutation GFP S152D showed an increase in cytoplasmic localization. S152D mutation showed decreased nuclear localization in both COS and NIH 3T3 cells in comparison to wild-type. 	
IGFBP3	Cell development/differentiation; Secreted; Secreted, signal peptide	P17936	3486	IGFBP3	7p13-p12	human	S138	PHOSPHORYLATION	451462	PPAPGNAsESEEDRS			apoptosis, induced			8567	2	0	0		
BCAP	Adaptor/scaffold	Q9EQ32	83490	Pik3ap1		mouse	Y445	PHOSPHORYLATION	448184	PGCDDELyESMAAFA		molecular association, regulation	cell differentiation, altered	PIK3R1(INDUCES)		12482418	2	0	0	regulate Akt activation and B-cell differentiation through binding to PI3KR1	
PIP4K2A	Carbohydrate Metabolism - inositol phosphate; EC 2.7.1.149; EC 2.7.1.68; Kinase, lipid; Motility/polarity/chemotaxis	P48426	5305	PIP4K2A	10p12.2	human	S304	PHOSPHORYLATION	450664	DGEEEGEsDGTHPVG	PIP5K	intracellular localization				3129	1	0	0		
TrkC	EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Protein kinase, TK; Protein kinase, tyrosine (receptor)	Q16288	4916	NTRK3	15q25	human	Y516	PHOSPHORYLATION	450003	PVIENPQyFRQGHNC			cell growth, altered			3503	2	4	66		
HCN2	Channel, cation; Membrane protein, integral; Membrane protein, multi-pass	O88703	15166	Hcn2		mouse	Y476	PHOSPHORYLATION	457528	FRQKIHDyYEHRYQG		activity, induced				6994	1	1	0	Y476F mutation in Hcn2 and Y554F mutation in Hcn4, abolishes the effect of PP2 on activation.	
PDCD4	Apoptosis	Q53EL6	27250	PDCD4	10q24	human	S457	PHOSPHORYLATION	458382	RGRKRFVsEGDGGRL		intracellular localization				7357	3	35	35	inhibits repressor activity of PDCD4 on AP-1 responsive promoters 	
SPRY2	Adaptor/scaffold; Inhibitor protein; Motility/polarity/chemotaxis	O43597	10253	SPRY2	13q31.1	human	Y227	PHOSPHORYLATION	455228	CCVKGLFyHCSNDDE	Sprouty	activity, inhibited; phosphorylation	transcription, altered			4413	1	0	0		
DVL2	Adaptor/scaffold; Motility/polarity/chemotaxis	O14641	1856	DVL2	17p13.1	human	Y275	PHOSPHORYLATION	12170305	VTLNMEKyNFLGISI	PDZ		transcription, induced			12021336	1	2	1	regulates Wnt3a/beta-catenin signaling 	
Mnk2	EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, CAMK; Protein kinase, Ser/Thr (non-receptor); Translation	Q8CDB0	17347	Mknk2		mouse	T249	PHOSPHORYLATION	447641	ISTPELLtPCGSAEY	Pkinase	enzymatic activity, induced				6207	1	1	0		
ATF-2	C2H2-type zinc finger protein; Transcription factor	P15336	1386	ATF2	2q32	human	S490	PHOSPHORYLATION	455782	QSTEPALsQIVMAPS		intracellular localization				5799	1	0	0	S472/480 are important for ionizing radiation-induced S phase checkpoint control	
BRCA1	EC 6.3.2.-; Nuclear receptor co-regulator; Transcription, coactivator/corepressor; Tumor suppressor; UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase	P38398	672	BRCA1	17q21	human	S988	PHOSPHORYLATION	448526	PPLFPIKsFVKTKCK		activity, induced; intracellular localization				6702307; 1886; 4556; 1753	6	0	0	colocalized with H2AX in nucleus after X-radiation or Fe-ion induced DNA damage	
PIK4CB iso2	Carbohydrate Metabolism - inositol phosphate; EC 2.7.1.67; Kinase, lipid; Motility/polarity/chemotaxis	Q9UBF8-2	5298	PI4KB	1q21	human	S294	PHOSPHORYLATION	457621	SNLKRTAsNPKVENE		molecular association, regulation; intracellular localization; enzymatic activity, induced		14-3-3 theta(INDUCES); 14-3-3 zeta(INDUCES); 14-3-3 gamma(INDUCES)		8260; 7836; 7204	3	14	9	S294 phosphorylated PIK4CB localizes in Golgi structures; interaction with 14-3-3 protects PIK4CB against dephosphorylation	
MAX	DNA binding protein; Transcription factor	P52164	60661	Max		rat	S11	PHOSPHORYLATION	449308	NDDIEVEsDEEQPRF	Filament; ATG16; Myosin_tail_1; IncA; Ax_dynein_light; Fib_alpha	molecular association, regulation			DNA(NOT_REPORTED)	2175	4	9	0	increases both the on- and off-rates for DNA binding	
MCAM	Cell adhesion; Membrane protein, integral	NP_001004768	448832	MCAM		chicken	S594	PHOSPHORYLATION	1243502	KNVVEVKsDKLSEEA	Chordopox_A13L		cytoskeletal reorganization			1172823	1	2	0		
Ron	EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Protein kinase, TK; Protein kinase, tyrosine (receptor)	Q62190	19882	Mst1r		mouse	Y1294	PHOSPHORYLATION	456484	EYCPDSLyHVMLRCW	Pkinase_Tyr	enzymatic activity, induced		Src(NOT_REPORTED)		6720	2	0	0	this site is responsible for constitutive activation of the MAP kinase pathway	
VHL	Tumor suppressor; UBIQUITIN LIGASE; Ubiquitin ligase	P40337	7428	VHL	3p25.3	human	S111	PHOSPHORYLATION	22516600	GTGRRIHsYRGHLWL	VHL	molecular association, regulation	cell cycle regulation; carcinogenesis, inhibited; apoptosis, induced; transcription, induced	Tip60(INDUCES); p300(INDUCES)		22495304	1	0	0	; positive regulator of p53;  initiates transcription on p53 target gene promoters in response to DNA damage;  tumor suppresor;  required for p53-dependent cell cycle arrest and apoptosis	
NHERF	Adaptor/scaffold; Motility/polarity/chemotaxis	O14745	9368	SLC9A3R1	17q25.1	human	S339	PHOSPHORYLATION	455752	ERAHQKRsSKRAPQM	EBP50_C-term	molecular association, regulation		CFTR(INDUCES)		12061	3	1	18		
Bcl-11B	C2H2-type zinc finger protein; Nuclear receptor co-regulator	Q99PV8	58208	Bcl11b		mouse	S664	PHOSPHORYLATION	14159422	RKPAPLPsPGLGGPA		molecular association, regulation		SENP1(INDUCES)		25573548	0	4	0		
IRS2	Adaptor/scaffold; Motility/polarity/chemotaxis	P81122	384783	Irs2		mouse	Y628	PHOSPHORYLATION	457098	YNPYPEDyGDIEIGS		molecular association, regulation		InsR(DISRUPTS)		9082	1	9	37		
SLC24A2	Membrane protein, integral; Membrane protein, multi-pass; Transporter	O54701	84550	Slc24a2		rat	Y365	PHOSPHORYLATION	3721716	LAEELGSyGKLKYYD		molecular association, regulation	endocytosis, inhibited	AP2M1(INDUCES)		27571200	1	0	0		
eEF-2	Translation; Translation elongation	P05197	29565	Eef2		rat	T57	PHOSPHORYLATION	448040	RAGETRFtDTRKDEQ	GTP_EFTU	activity, inhibited				5578	24	25	48	Phosphorylation of T56 correlates with inhibition of protein synthesis.	
NFAT1	DNA binding protein; Transcription factor	Q60591	18019	Nfatc2		mouse	S136	PHOSPHORYLATION	449623	RGRDAGLsPEQPALA			transcription, inhibited			1188	0	7	0		
capicua	DNA binding protein; Transcription factor	Q96RK0	23152	CIC	19q13.2	human	S1389	PHOSPHORYLATION	4952030	SPRAILGsYRKKRKN		molecular association, regulation; intracellular localization		KPNA3(DISRUPTS)		17431533	1	0	0		
IkB-beta	Inhibitor protein	Q9JIA3	81525	Nfkbib		rat	Y161	PHOSPHORYLATION	457691	PRDASDTyLTQSQDH		molecular association, regulation	apoptosis, induced	NFkB-p65(INDUCES)		7313	1	0	1		
FAK	EC 2.7.1.112; EC 2.7.10.2; KINASE; Kinase, protein; Protein kinase, TK; Protein kinase, tyrosine (non-receptor)	Q00944	396416	PTK2		chicken	Y576	PHOSPHORYLATION	447889	RYMEDSTyYKASKGK	Pkinase_Tyr	activity, induced; phosphorylation; enzymatic activity, induced				2577; 1087	68	40	2552		
ULK1	Autophagy; EC 2.7.1.37; EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor)	O75385	8408	ULK1	12q24.3	human	S638	PHOSPHORYLATION	3176158	FDFPKTPsSQNLLAL		phosphorylation	autophagy, altered			18668217	1	18	36	facilitates rephosphorylation at S758 	
EDC3	RNA processing	Q96F86	80153	EDC3	15q24.1	human	S161	PHOSPHORYLATION	1211074	SFRRRHNsWSSSSRH		molecular association, regulation		14-3-3 beta(INDUCES)		12525211	1	18	302		
NFkB-p65	DNA binding protein; Nuclear receptor co-regulator; Transcription factor	Q04206	5970	RELA	11q13	human	S205	PHOSPHORYLATION	1295501	RVNRNSGsCLGGDEI		intracellular localization	transcription, induced; transcription, altered			1172828; 3475702	3	0	0		
CBP	ACETYLTRANSFERASE; Acetyltransferase; DNA binding protein; EC 2.3.1.48; Motility/polarity/chemotaxis; Nuclear receptor co-regulator; Transcription, coactivator/corepressor	P45481	12914	Crebbp		mouse	S436	PHOSPHORYLATION	447689	CLPLKNAsDKRNQQT		molecular association, regulation	cell differentiation, altered; transcription, induced; transcription, altered; cell growth, altered	CREB(DISRUPTS)		1460; 2483409; 14148610	4	0	0		
POU4F1	Cell development/differentiation; DNA binding protein; Transcription factor	Q01851	5457	POU4F1	13q31.1	human	S122	PHOSPHORYLATION	6311910	DLLDHISsPSLALMA		activity, induced	cell differentiation, altered; cell differentiation, induced; transcription, induced			6320801; 6277004	2	0	0		
RhoGDI alpha	Apoptosis; Cell adhesion; Cell development/differentiation; G protein regulator, misc.; Motility/polarity/chemotaxis	P52565	396	ARHGDIA	17q25.3	human	S174	PHOSPHORYLATION	452196	KGMLARGsYSIKSRF	Rho_GDI	activity, induced; molecular association, regulation	transcription, altered	RAC1(DISRUPTS); Cdc42 iso1(DISRUPTS)		12021318; 4646401	3	0	0	RhoA activation	
eNOS	Amino Acid Metabolism - arginine and proline; EC 1.14.13.39; Oxidoreductase	Q62600	24600	Nos3		rat	S1176	PHOSPHORYLATION	447884	TSRIRTQsFSLQERQ		enzymatic activity, induced				1071	141	8	7	Activated in vitro and during ischaemia in the presence of Ca2+ calmodulin.	
NKCC2	Membrane protein, integral; Membrane protein, multi-pass; Transporter	P55016	25065	Slc12a1		rat	T114	PHOSPHORYLATION	459122	KIEYYRNtGSVSGPK	AA_permease_N	activity, induced				2831757	3	2	0	observed in triple mutant T96/111/101A	
FOXM1 iso2	DNA binding protein; Transcription factor	Q08050-2	2305	FOXM1	12p13	human	S251	PHOSPHORYLATION	10897608	MIQFAINsTERKRMT	Fork_head	molecular association, regulation; phosphorylation	cell cycle regulation; transcription, induced	CBP(INDUCES)		10353923	1	1	0	increases phosphorylation of FOXM1 T596 by CDK1 in vivo and in vitro	
IRS1	Adaptor/scaffold; Motility/polarity/chemotaxis	P35569	16367	Irs1		mouse	S318	PHOSPHORYLATION	451399	MVGGKPGsFRVRASS		phosphorylation				1910515	11	8	0	Phosphorylation of S318 leads to an increase of phospho-Ser473 Akt1 in L6GLUT4 myotubes.	
Cdc25A	EC 3.1.3.48; Motility/polarity/chemotaxis; PHOSPHATASE; Protein phosphatase, dual-specificity	P48964	12530	Cdc25a		mouse	S122	PHOSPHORYLATION	449127	PALKRSHsDSLDQDT	M-inducer_phosp	protein degradation; intracellular localization	cell cycle regulation; apoptosis, altered; cytoskeletal reorganization			4835200; 6271047	6	1	0	centrosome amplification  and colocalization with Cdc25A in S122A  mutant cells	
DRD1	GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR	P18901	24316	Drd1		rat	T428	PHOSPHORYLATION	458339	SVILDYDtDVSLEKI		receptor desensitization, altered; intracellular localization				7381	1	0	0		
FPR2	GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Motility/polarity/chemotaxis; Receptor, GPCR	P25090	2358	FPR2	19q13.3-q13.4	human	Y302	PHOSPHORYLATION	3176600	SCLNPMLyVFVGQDF	7tm_1; TM	receptor desensitization, altered				8619	1	0	0	downregulates PLD activation	
Rad9	Apoptosis; Cell cycle regulation; DNA replication; Deoxyribonuclease; EC 3.1.11.2	Q99638	5883	RAD9A	11q13.1-q13.2	human	S387	PHOSPHORYLATION	449815	SPVLAEDsEGEG___		molecular association, regulation; phosphorylation	cell cycle regulation	TOPBP1(INDUCES)		15235227; 15571605; 14790319; 8762	6	14	1		
tau iso8	Cytoskeletal protein	P10636-8	4137	MAPT	17q21.1	human	S324	PHOSPHORYLATION	449328	KVTSKCGsLGNIHHK	Tubulin-binding	molecular association, regulation	cytoskeletal reorganization			10303912; 19084437	6	2	2		
cortactin	Actin binding protein; Cytoskeletal protein; Motility/polarity/chemotaxis	Q14247	2017	CTTN	11q13	human	S405	PHOSPHORYLATION	447700	KTQTPPVsPAPQPTE		molecular association, regulation; protein conformation	carcinogenesis, altered; endocytosis, altered; cell motility, altered; cytoskeletal reorganization; cell adhesion, altered	N-WASP(INDUCES)		14318400; 17431527	14	46	113		
GEM	G protein; G protein, monomeric, RGK	P55040	2669	GEM	8q13-q21	human	S287	PHOSPHORYLATION	1211200	NMAFKLKsKSCHDLS		molecular association, regulation		KPNA5(DISRUPTS)		1172801	2	1	0	interaction abolished in triple phosphomimetic mutant S261/287/289D	
CCKBR	GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR	P32239	887	CCKBR	11p15.4	human	Y438	PHOSPHORYLATION	471082	ASLSRLSyTTISTLG		molecular association, regulation; phosphorylation		SHP-2(INDUCES)		8993	1	0	0	Mutation of Y438F abrogates AKT phosphorylation on Ser473 and SHP-2 on Y584, but still promotes equivalent amounts of Erk1/2 activation (phospho-Erk epitope).	
TORC2	Transcription, coactivator/corepressor	Q8BH09	74343	Crtc2		mouse	S369	PHOSPHORYLATION	454651	PQLQGSHsHPSLPAS		molecular association, regulation		14-3-3 beta(INDUCES)		3173900	2	1	6		
53BP1	Transcription, coactivator/corepressor	P70399	27223	Tp53bp1		mouse	S376	PHOSPHORYLATION	452380	TPFIVPSsPTEQGGR		molecular association, regulation	cell cycle regulation	PLK1(INDUCES)		12190200	2	28	6		
ER-beta	DNA binding protein; Nuclear receptor	O08537	13983	Esr2		mouse	S61	PHOSPHORYLATION	452089	MNYSVPSsTGNLEGG	ERbeta_N; Oest_recep	protein conformation				8930	0	1	0		
PIAS1	EC 6.3.2.-; Nuclear receptor co-regulator; SUMO LIGASE; SUMO conjugating system; Transcription, coactivator/corepressor	O75925	8554	PIAS1	15q	human	S468	PHOSPHORYLATION	4700794	DLTIDSSsDEEEEEP		molecular association, regulation	transcription, inhibited	SUMO2(INDUCES); SUMO1(INDUCES)		6829202	2	5	0		
LIMK2	EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, Ser/Thr (non-receptor); Protein kinase, TKL	P53670	29524	Limk2		rat	T505	PHOSPHORYLATION	448683	SDRKKRYtVVGNPYW	Pkinase_Tyr	activity, induced				2328	10	0	0	T505 phosphorylation is also essential for the induction of actin cytoskeletal changes.	
GGA1	Adaptor/scaffold; Vesicle protein	Q9UJY5	26088	GGA1	22q13.31	human	S355	PHOSPHORYLATION	455525	EQPSASVsLLDDELM		molecular association, regulation; activity, inhibited		IGF2R(DISRUPTS)		5388	3	0	0		
p27Kip1	Cell cycle regulation; Inhibitor protein; Protein kinase, regulatory subunit	P46414	12576	Cdkn1b		mouse	S178	PHOSPHORYLATION	450208	EENVSDGsPNAGTVE			cell cycle regulation; cell growth, altered			3002	5	4	1		
NOP5	Cell development/differentiation; RNA binding protein	Q9Y2X3	51602	NOP58	2q33.1	human	S502	PHOSPHORYLATION	459895	HIKEEPLsEEEPCTS		sumoylation				15510800	0	47	19	required for sumoylation of K497	
FCP1	EC 3.1.3.16; Motility/polarity/chemotaxis; PHOSPHATASE; Protein phosphatase, Ser/Thr (non-receptor); Transcription initiation complex	Q9Y5B0	9150	CTDP1	18q23	human	S575	PHOSPHORYLATION	11276300	AGESLDQsMEEEEEE		molecular association, regulation; enzymatic activity, induced	transcription, induced	GTF2F2(INDUCES)		10296902	1	1	0		
HSP70	Chaperone; Motility/polarity/chemotaxis	P08107	3303	HSPA1A	6p21.3	human	Y525	PHOSPHORYLATION	450945	MVQEAEKyKAEDEVQ	HSP70	intracellular localization				3197	1	3	21	Phosphorylation at Y525 facilitates nuclear acumulation of HSP70 following heat stress.	
ILT2	Membrane protein, integral; Receptor, misc.	Q8N423	10288	LILRB2	19q13.4	human	Y533	PHOSPHORYLATION	451318	DAQEENLyAAVKDTQ	Herpes_gE; Protocadherin; Bravo_FIGEY	molecular association, regulation; phosphorylation		CSK(INDUCES); SHP-1(INDUCES)		4315; 3538	2	0	11	Mutation of Y533 prevented binding in vivo. ;  necessary for serotonin release; tyrosine phosphorylation of ILT2	
vimentin	Cytoskeletal protein; Motility/polarity/chemotaxis	P08670	7431	VIM	10p13	human	S9	PHOSPHORYLATION	455450	STRSVSSsSYRRMFG	Filament_head		cell motility, altered			7549203	3	2	3		
NACA	Motility/polarity/chemotaxis; Transcription, coactivator/corepressor	P70670	17938	Naca		mouse	S2015	PHOSPHORYLATION	454238	PELEEQDsTQTATQQ		intracellular localization	transcription, altered			12525205	2	0	0	regulates expression of osteocalcin and COL1A1	
TPH2	Amino Acid Metabolism - tryptophan; EC 1.14.16.4; Oxidoreductase	Q8IWU9	121278	TPH2	12q21.1	human	S19	PHOSPHORYLATION	470085	YWARRGFsLDSAVPE		protein stabilization; molecular association, regulation; enzymatic activity, induced		14-3-3 beta(INDUCES); 14-3-3 epsilon(INDUCES); 14-3-3 gamma(INDUCES)		8857; 2425201; 970070	4	5	2	modulates serotonin production	
Ron	EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Protein kinase, TK; Protein kinase, tyrosine (receptor)	Q04912	4486	MST1R	3p21.3	human	Y1360	PHOSPHORYLATION	456488	YVQLPATyMNLGPST		phosphorylation	cell growth, altered			4335	3	0	0		
Kit	EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Protein kinase, TK; Protein kinase, tyrosine (receptor)	P10721	3815	KIT	4q11-q12	human	Y547	PHOSPHORYLATION	13876400	VMILTYKyLQKPMYE		enzymatic activity, induced				13852012	1	1	0		
MC2R	GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR	Q01718	4158	MC2R	18p11.2	human	S280	PHOSPHORYLATION	456325	PFIYAFRsPELRDAF		receptor desensitization, altered; activity, inhibited				6572	1	0	0		
IKK-gamma	Adaptor/scaffold; Protein kinase, regulatory subunit	Q9Y6K9	8517	IKBKG	Xq28	human	S68	PHOSPHORYLATION	1226900	LRDAIRQsNQILRER	NEMO	molecular association, regulation		IKK-gamma(DISRUPTS); IKKB(DISRUPTS)		1172820	1	0	0	phosphorylation attenuates amino-terminal protein dimerization;  decreases TNF-alpha-induced NF-kB and IKKalpha activity.	
GIRK4	Channel, potassium; Membrane protein, integral; Membrane protein, multi-pass	P48548	29713	Kcnj5		rat	Y32	PHOSPHORYLATION	3146604	IPKQARDyIPIATDR		activity, inhibited				8596	1	0	0		
PR	DNA binding protein; Nuclear receptor	P06401	5241	PGR	11q22-q23	human	S400	PHOSPHORYLATION	449842	GAEASARsPRSYLVA	Prog_receptor		transcription, induced			4356	7	0	0	Wild-type or S400A mutant increased PR transcriptional activity in the presence or absence of progestin.  Activated CDK2 induces ligand-independent PR transcription in PR null cells but not in T47DY breast cancer cells. CDK2 -induced PR transcriptional activity is inhibited by CDK2, inhibitor p27. Ligand and mitogen-induced PR transcriptional activity is enhanced in cells with low levels of p27. PR S400 is required for ligand-independent PR transcriptional activity in p27-/- cells. 	
DRD1	GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR	P18901	24316	Drd1		rat	S259	PHOSPHORYLATION	455303	ECAQSESsFKMSFKR	7tm_1	receptor desensitization, altered				4475	1	0	0		
PREX1	Guanine nucleotide exchange factor, Rac/Rho	Q8TCU6	57580	PREX1	20q13.13	human	S1169	PHOSPHORYLATION	18704703	DTMSYRDsYSECNSN		activity, induced	cell growth, induced			18668001; 28723102	2	0	0	increased Rac activity	
MEKK3	EC 2.7.11.25; KINASE; Kinase, protein; Protein kinase, STE; Protein kinase, Ser/Thr (non-receptor)	Q99759	4215	MAP3K3	17q23.3	human	S526	PHOSPHORYLATION	458796	MSGTGMRsVTGTPYW	Pkinase	enzymatic activity, induced	transcription, altered			2195468; 1903001	4	1	0	necessary for MEKK3 T294 phosphorylation and its interaction with 14-3-3beta; S526 functions in LPS-induced IL6 transcription.	
CACNA1D	Channel, calcium; Membrane protein, integral; Membrane protein, multi-pass	Q01668	776	CACNA1D	3p14.3	human	S1490	PHOSPHORYLATION	465731	DEFKRIWsEYDPEAK		activity, induced				8072	1	0	0	required for IGF-1 induced channel potentiation	
GluR1	Channel, calcium; Channel, ligand-gated; Membrane protein, integral; Membrane protein, multi-pass	P19490	50592	Gria1		rat	S849	PHOSPHORYLATION	448565	FCLIPQQsINEAIRT		activity, induced; protein processing; intracellular localization		GluR2(INDUCES)		11959; 1172201; 4402; 1702	64	2	3	calpain cleavage	
Smad2	DNA binding protein; Transcription factor	Q15796	4087	SMAD2	18q21.1	human	S250	PHOSPHORYLATION	448795	TGSPAELsPTTLSPV		activity, induced; protein stabilization; molecular association, regulation; intracellular localization; protein conformation	cell motility, altered; transcription, induced	Smad4(INDUCES)		6277008; 3386; 1956	3	0	0	induce vascular invasion	
DRD1	GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR	P18901	24316	Drd1		rat	T268	PHOSPHORYLATION	3078003	KMSFKREtKVLKTLS	7tm_1	intracellular localization				8435	1	0	0		
calponin 1	Actin binding protein; Contractile protein; Motility/polarity/chemotaxis; Myosin binding protein	P26932	396522	CNN1		chicken	S175	PHOSPHORYLATION	450890	MGTNKFAsQQGMTAY	Calponin	molecular association, regulation		ACTA1(DISRUPTS)		8316	2	1	0	f-actin (rabbit skeletal muscle) shown by co-sedimentation	
WIP	Actin binding protein; Motility/polarity/chemotaxis	O43516	7456	WIPF1	2q31.1	human	S488	PHOSPHORYLATION	449880	RNESRSGsNRRERGA		molecular association, regulation		WASP(DISRUPTS)		2429	3	0	0		
Cdc25C	EC 3.1.3.48; Motility/polarity/chemotaxis; PHOSPHATASE; Protein phosphatase, dual-specificity	P30307	995	CDC25C	5q31	human	T130	PHOSPHORYLATION	449911	PAQLLCStPNGLDRG	M-inducer_phosp		cell cycle regulation; cell adhesion, altered			2459; 15331005	4	0	7	colocalizes with PLK1 at centrosomes	
eNOS	Amino Acid Metabolism - arginine and proline; EC 1.14.13.39; Oxidoreductase	Q62600	24600	Nos3		rat	S1178	PHOSPHORYLATION	467802	RIRTQSFsLQERQLR		enzymatic activity, induced				3342613	7	5	1		
NR4A2	DNA binding protein; Nuclear receptor	P43354	4929	NR4A2	2q22-q23	human	S125	PHOSPHORYLATION	487428	GSVYYKPsSPPTPTT			transcription, induced			12245	1	0	0	S125C mutation attenuated NR4A2 -induced transcriptional activity.	
NPHP1	Cell adhesion	O15259	4867	NPHP1	2q13	human	S121	PHOSPHORYLATION	26395106	PTEEEEEsESEDSED		molecular association, regulation; intracellular localization		PACS-1(INDUCES)		25785405	1	0	0		
p90RSK	EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor); Translation	Q63531	81771	Rps6ka1		rat	S363	PHOSPHORYLATION	447989	TSRTPRDsPGIPPSA	Pkinase_C	activity, induced				849	36	20	4		
PTGER4	GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR	P35408	5734	PTGER4	5p13.1	human	S379	PHOSPHORYLATION	450697	AMSGHSRsFISRELK		molecular association, regulation		ARRB1(INDUCES)		3068	1	0	0		
Hic-5	Motility/polarity/chemotaxis; Nuclear receptor co-regulator; Transcription, coactivator/corepressor	Q62219	21804	Tgfb1i1		mouse	Y38	PHOSPHORYLATION	456816	TLTPPPPyGHQPQTG	Paxillin		cytoskeletal reorganization			6852	1	1	2	phosphorylation of this site after EGF induction leads to reduction of Rac activity and formation of lamellipodia 	
Ikaros	C2H2-type zinc finger protein; DNA binding protein; Transcription factor	Q03267	22778	Ikzf1		mouse	S388	PHOSPHORYLATION	451351	REASPSNsCQDSTDT		activity, inhibited	cell cycle regulation		DNA(DISRUPTS)	3559	1	2	5		
cofilin 1	Cytoskeletal protein; Motility/polarity/chemotaxis	P23528	1072	CFL1	11q13	human	S23	PHOSPHORYLATION	9218412	NDMKVRKsSTPEEVK	Cofilin_ADF	molecular association, regulation	cytoskeletal reorganization	14-3-3 zeta(INDUCES)		25712654	1	2	1	inhibition of depolymerization of actin, cessation of degranulation 	
NFAT3	DNA binding protein; Transcription factor	Q14934	4776	NFATC4	14q11.2	human	S170	PHOSPHORYLATION	448860	GGAFFSPsPGSSSLS		intracellular localization; activity, inhibited	cell differentiation, altered; transcription, altered; cell growth, altered			2030; 12482414	5	0	1		
DDX5	EC 3.6.1.-; EC 3.6.4.13; Helicase; Nuclear receptor co-regulator; RNA binding protein; RNA splicing; Spliceosome	P17844	1655	DDX5	17q21	human	Y595	PHOSPHORYLATION	478485	MNQQAYAyPATAAAP			apoptosis, inhibited			9627	1	1	0		
BLM	DNA repair; DNA replication; EC 3.6.1.-; EC 3.6.4.12; Helicase	P54132	641	BLM	15q26.1	human	S646	PHOSPHORYLATION	15349300	LKHERFQsLSFPHTK		molecular association, regulation; intracellular localization		NCL(INDUCES); PML(INDUCES)		15278812	1	0	0		
GRASP55	Motility/polarity/chemotaxis; Vesicle protein	Q9R064	113961	Gorasp2		rat	T222	PHOSPHORYLATION	470124	LPGQMTGtPITPLKD		molecular association, regulation	cytoskeletal reorganization	GRASP55(DISRUPTS)		12576800	2	11	4	inhibits Golgi stack formation in interphase cells and enhances Golgi fragmentation in mitotic cells	
CBX4	EC 6.3.2.-; SUMO LIGASE; SUMO ligase; Transcription, coactivator/corepressor	O00257	8535	CBX4	17q25.3	human	T497	PHOSPHORYLATION	470079	SLQVKPEtPASAAVA		sumoylation; intracellular localization; enzymatic activity, induced				8962	1	0	0	increases CBX4 activity as a SUMO E3 ligase and sumoylation of HIPK2 	
METTL1	EC 2.1.1.33; Methyltransferase; RNA processing	Q9UBP6	4234	METTL1	12q13	human	S27	PHOSPHORYLATION	3627513	YYRQRAHsNPMADHT		enzymatic activity, inhibited				7095	1	4	52		
STXBP3	Vesicle protein	Q60770	20912	Stxbp3		mouse	Y219	PHOSPHORYLATION	463816	EKKLEDYyKIDEKGL	Sec1	molecular association, regulation		STX4(DISRUPTS); DOC2B(INDUCES)		28722429; 2831760; 7872	4	0	0	2-deoxy-glucose uptake in adipocytes	
TrkA	EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Protein kinase, TK; Protein kinase, tyrosine (receptor)	P35739	59109	Ntrk1		rat	Y683	PHOSPHORYLATION	447763	RDIYSTDyYRVGGRT	Pkinase_Tyr	molecular association, regulation; enzymatic activity, induced	cell cycle regulation; cytoskeletal reorganization; cell growth, altered	DNAJA3(INDUCES)		6193; 5205; 5955615	9	2	10	neurite outgrowth;  acidic substitution of Y683, Y684 is constitutively active.	
NMDAR2A	Channel, ligand-gated; Membrane protein, integral; Membrane protein, multi-pass	Q12879	2903	GRIN2A	16p13.2	human	Y1267	PHOSPHORYLATION	461052	PATGEQVyQQDWAQN	NMDAR2_C	activity, induced				10274616	3	0	24	potentiation of receptor currents mediated by Src	
FcGR2B	Cell surface; Membrane protein, integral	P31994	2213	FCGR2B	1q23	human	Y292	PHOSPHORYLATION	448507	GAENTITySLLMHPD		molecular association, regulation		SHP-2(INDUCES)		8502	3	2	1		
DRAK2	EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, CAMK; Protein kinase, Ser/Thr (non-receptor)	Q91XS8	170904	Stk17b		rat	S350	PHOSPHORYLATION	1735800	PEDDSLLsKRFRFDD		intracellular localization				1713138	2	1	0	regulates the activity of the NLS	
PTGER4	GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR	P35408	5734	PTGER4	5p13.1	human	S374	PHOSPHORYLATION	450695	QRTSSAMsGHSRSFI		molecular association, regulation		ARRB1(INDUCES)		3068	1	0	0		
AKAP13	Adaptor/scaffold; Guanine nucleotide exchange factor, Rac/Rho	Q12802	11214	AKAP13	15q24-q25	human	S1565	PHOSPHORYLATION	452184	LSPFRRHsWGPGKNA		molecular association, regulation; activity, inhibited		14-3-3 beta(INDUCES); 14-3-3 gamma(INDUCES)		2189200; 4100	2	10	11	suppresses AKAP13 RhoGEF activity against RhoA	
PIP5K1B	Carbohydrate Metabolism - inositol phosphate; EC 2.7.1.68; Kinase, lipid	P70181	18719	Pip5k1b		mouse	S413	PHOSPHORYLATION	27461455	PSKKRCNsIAALKAT		enzymatic activity, inhibited				28722108	1	2	0		
ADD1	Cytoskeletal protein; Motility/polarity/chemotaxis	Q63028	24170	Add1		rat	S724	PHOSPHORYLATION	449829	KKKFRTPsFLKKSKK		intracellular localization	cytoskeletal reorganization			4014; 2346	16	27	153		
p90RSK	EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor); Translation	Q63531	81771	Rps6ka1		rat	S154	PHOSPHORYLATION	10355000	GDLFTRLsKEVMFTE	Pkinase	molecular association, regulation; intracellular localization; enzymatic activity, induced		14-3-3 beta(INDUCES)		10144225	2	0	0	!4-3-3  binding inhibits S363 andd S380 phosphorylation and enzyme activity.; 14-3-3B binding in vitro and in vivo 	
KCC2	Membrane protein, integral; Membrane protein, multi-pass; Transporter	Q91V14	57138	Slc12a5		mouse	Y926	PHOSPHORYLATION	14932400	SDISAYTyEKTLVME		protein degradation				14790321	1	0	0	decreases the cell surface stability of SLC12A5 (aka KCC2)	
SOCS3	Inhibitor protein	O14543	9021	SOCS3	17q25.3	human	Y221	PHOSPHORYLATION	450447	IREFLDQyDAPL___	SOCS_box	protein degradation; molecular association, regulation	transcription, altered	Crk(INDUCES); Nck1(INDUCES); TCEB1(DISRUPTS)		3906; 8821; 2999	3	0	0		
Snail1	C2H2-type zinc finger protein; Transcription factor	O95863	6615	SNAI1	20q13.2	human	S92	PHOSPHORYLATION	452602	VAELTSLsDEDSGKG	CAP_N	protein degradation; molecular association, regulation; activity, inhibited	transcription, altered	SAP30(INDUCES)		11419352	2	2	0	reqired for cell survival 	
NFkB-p65	DNA binding protein; Nuclear receptor co-regulator; Transcription factor	Q04206	5970	RELA	11q13	human	S536	PHOSPHORYLATION	447800	SGDEDFSsIADMDFS		activity, induced; protein stabilization; molecular association, regulation; intracellular localization	apoptosis, altered; cell motility, altered; transcription, induced; transcription, altered; cell growth, altered	TAFII31(INDUCES); CDK5RAP3(DISRUPTS)		2466205; 1173024; 1195; 4966805; 18378510; 5638; 6815; 1214500; 6941; 4619; 6934; 4617; 4313602; 4568; 6126; 1194; 18378505; 13826400; 1910504; 7246; 5633; 6172; 7644600; 3391000	103	0	0	Regulatory function of phosphorylation is dependent on individual regulated genes.	
Myf-5	DNA binding protein; Transcription factor	P13349	4617	MYF5	12q21	human	S133	PHOSPHORYLATION	457385	NAIRYIEsLQELLRE	HLH	activity, induced				7047	1	0	0		
GluR5 iso2	Channel, ligand-gated; Membrane protein, integral; Membrane protein, multi-pass	P39086-2	2897	GRIK1	21q22.11	human	S879	PHOSPHORYLATION	457626	QKKIKKKsRTKGKSS		receptor desensitization, altered; receptor internalization, altered				762736	2	0	0	induced by phorbol ester	
APP	Apoptosis; Cell surface; Membrane protein, integral; Receptor, misc.; Transcription factor	P05067	351	APP	21q21.3	human	T743	PHOSPHORYLATION	448523	VEVDAAVtPEERHLS	APP_amyloid	protein stabilization; molecular association, regulation; intracellular localization	cell cycle regulation; cell growth, altered	Lyn(INDUCES); Src(INDUCES); Crk(INDUCES); Abl(INDUCES); PLCG1(INDUCES); GRB7(INDUCES); Shc2(INDUCES); Shc3(INDUCES); Fe65(INDUCES); Nck1(INDUCES); Shc1(INDUCES); DAB1(INDUCES); APPBP1(INDUCES); PLCG2(INDUCES); Grb2(INDUCES); Pin1(INDUCES)		19016928; 3082; 9938511; 2855906	30	2	3		
Cdc25A	EC 3.1.3.48; Motility/polarity/chemotaxis; PHOSPHATASE; Protein phosphatase, dual-specificity	P30304	993	CDC25A	3p21	human	S82	PHOSPHORYLATION	450248	GSSESTDsGFCLDSP		protein degradation; molecular association, regulation; ubiquitination	cell cycle regulation	BTRC(INDUCES); FBW1B(INDUCES)		2952; 7346; 14146303; 3594; 10353922	5	0	0		
RAF1	EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, Ser/Thr (non-receptor); Protein kinase, TKL	P04049	5894	RAF1	3p25	human	Y341	PHOSPHORYLATION	447750	GQRDSSYyWEIEASE		enzymatic activity, inhibited; intracellular localization; phosphorylation; enzymatic activity, induced				6526; 8397; 3340200; 5692; 6528; 6052; 5121526; 1253; 2940; 12068402; 6115934	28	1	1		
SNCA	Adaptor/scaffold	P37840	6622	SNCA	4q21	human	Y125	PHOSPHORYLATION	448279	VDPDNEAyEMPSEEG	Synuclein	activity, inhibited				6191	5	0	0	mutation of Y125 to F increased the inhibitory action of SNCA on phospholipase D activity.	
Rin1	Guanine nucleotide exchange factor, Rab	Q13671	9610	RIN1	11q13.2	human	S351	PHOSPHORYLATION	451364	RPLLRSMsAAFCSLL		molecular association, regulation; intracellular localization		14-3-3 beta(INDUCES)		3570	3	11	4		
FANCA	DNA repair	O15360	2175	FANCA	16q24.3	human	S1449	PHOSPHORYLATION	460787	AAPDADLsQEPHLF_		molecular association, regulation; ubiquitination	chromatin organization, altered		DNA(INDUCES)	5930047	1	3	17	level of monoubiquitinated FANCD2 was decreased in FANCA S1449A mutant	
p53	Activator protein; DNA binding protein; Motility/polarity/chemotaxis; Nuclear receptor co-regulator; Transcription factor; Tumor suppressor	P04637	7157	TP53	17p13.1	human	K382	ACETYLATION	458977	QSTSRHKkLMFKTEG		molecular association, regulation	apoptosis, induced; transcription, induced; transcription, altered	TAF1(INDUCES)	DNA(INDUCES)	1908950; 5010605; 2790309; 7647800	97	4	0	ZNF420 (Apak) represses p53 activity by attenuating its acetylation 	
ABCA1	Membrane protein, integral; Membrane protein, multi-pass; Transporter; Vesicle protein	P41233	11303	Abca1		mouse	T1305	PHOSPHORYLATION	450309	IDPESREtDLLSGMD		protein degradation; protein processing				2926	1	0	0	Mutants showed increase of cell surface protein levels. ; T1286A and T1305A mutants are not degraded by calpain or stabilized by apoA-1. 	
Cx43	Channel, misc.; Membrane protein, integral; Membrane protein, multi-pass; Motility/polarity/chemotaxis	P08050	24392	Gja1		rat	S365	PHOSPHORYLATION	459207	IVDQRPSsRASSRAS		activity, induced; protein conformation				1713143; 8412	9	10	2		
vimentin	Cytoskeletal protein; Motility/polarity/chemotaxis	P08670	7431	VIM	10p13	human	S66	PHOSPHORYLATION	451765	GVYATRSsAVRLRSS	Filament_head; DUF2464	molecular association, regulation	cytoskeletal reorganization	vimentin(DISRUPTS)		2214	5	5	17		
p53	Activator protein; DNA binding protein; Motility/polarity/chemotaxis; Nuclear receptor co-regulator; Transcription factor; Tumor suppressor	P04637	7157	TP53	17p13.1	human	K386	ACETYLATION	486382	RHKKLMFkTEGPDSD			apoptosis, induced; transcription, altered			2790309; 7647800	5	2	1	 ; ZNF420 (Apak) represses p53 activity by attenuating its acetylation ;  p53 8KR mutant can be still degraded by Mdm2; p53 8KR mutation (K120/164/370/372/373/381/382/386R) impairs p53-dependent transcription	
PKACA	EC 2.7.11.11; KINASE; Kinase, protein; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor)	P05132	18747	Prkaca		mouse	S339	PHOSPHORYLATION	449886	EEEEIRVsINEKCGK	Pkinase_C	molecular association, regulation		PDK1(INDUCES)		9721208	8	20	19		
Rb	Nuclear receptor co-regulator; Transcription, coactivator/corepressor; Tumor suppressor	P06400	5925	RB1	13q14.2	human	T252	PHOSPHORYLATION	449821	PINGSPRtPRRGQNR			cell cycle regulation			4214807	13	12	53		
GCH1	Cofactor and Vitamin Metabolism - folate biosynthesis; EC 3.5.4.16; Hydrolase	P22288	29244	Gch1		rat	T91	PHOSPHORYLATION	10428813	KTPWRAAtAMQFFTK		enzymatic activity, induced				10353908	1	0	0		
STLK3	EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, STE; Protein kinase, Ser/Thr (non-receptor)	Q9UEW8	27347	STK39	2q24.3	human	S323	PHOSPHORYLATION	450932	LCLQKDPsKRPTAAE	Pkinase	enzymatic activity, induced				3187	1	0	0		
mTOR	Autophagy; EC 2.7.11.1; KINASE; Kinase, protein; Motility/polarity/chemotaxis; Protein kinase, ATYPICAL; Protein kinase, Ser/Thr (non-receptor)	Q9JLN9	56717	Mtor		mouse	S2448	PHOSPHORYLATION	447578	RSRTRTDsYSAGQSV		intracellular localization				5604	90	6	84		
Per1	Transcription factor	O35973	18626	Per1		mouse	S663	PHOSPHORYLATION	451684	SYTASSAsDDDKQRA		intracellular localization				3802	1	0	0		
MDM2	EC 6.3.2.-; EC 6.3.2.19; Inhibitor protein; Ligase; UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase	Q00987	4193	MDM2	12q14.3-q15	human	S256	PHOSPHORYLATION	459215	FEVESLDsEDYSLSE		activity, induced				4379	3	1	0	promotes p53 degradation	
S100A11	Calcium-binding protein; Cell cycle regulation; DNA replication	P31949	6282	S100A11	1q21	human	S94	PHOSPHORYLATION	10888706	LAMACHDsFLKAVPS		intracellular localization	cell growth, altered	NCL(INDUCES)		10144221	1	0	1	Nuclear translocation is mediated by T10 phosphorylation. Calcium induced growth inhibition is mediated by T10 and S94 phosphorylation.	
STAT3	DNA binding protein; Motility/polarity/chemotaxis; Nuclear receptor co-regulator; Transcription factor	P40763	6774	STAT3	17q21.31	human	S727	PHOSPHORYLATION	448191	NTIDLPMsPRTLDSL		activity, induced; molecular association, regulation; intracellular localization; activity, inhibited	apoptosis, altered; carcinogenesis, induced; cell differentiation, altered; cell motility, altered; transcription, induced; transcription, altered; cell growth, altered	gp130(DISRUPTS); p300(INDUCES)	DNA(INDUCES)	7613722; 5410107; 2630614; 5965; 2539700; 5410116; 5410109; 5739; 794; 6115905; 19088701; 5987; 5410106; 6487; 3400804; 5704; 5581; 6415; 14151808; 6409; 2698000; 5174; 6407; 6440; 5845; 5918; 17630406; 7324137; 6271031	121	22	66		
PKD1	Autophagy; EC 2.7.11.13; KINASE; Kinase, protein; Motility/polarity/chemotaxis; Protein kinase, CAMK; Protein kinase, Ser/Thr (non-receptor)	Q15139	5587	PRKD1	14q11	human	S205	PHOSPHORYLATION	449896	GVRRRRLsNVSLTGV		molecular association, regulation		14-3-3 beta(INDUCES)		5785	5	20	58		
Tks5	Adaptor/scaffold	O89032	14218	Sh3pxd2a		mouse	Y619	PHOSPHORYLATION	3736027	ALEEETIyENEGFRP			cell cycle regulation; cell motility, altered			2790302	1	1	1		
CTNNB1	Actin binding protein; Cell adhesion; Motility/polarity/chemotaxis; Nuclear receptor co-regulator; Transcription factor	P35222	1499	CTNNB1	3p21	human	T102	PHOSPHORYLATION	3075002	RAAMFPEtLDEGMQI		protein degradation	cell motility, altered	CTNNA1(INDUCES)		8383	2	0	0		
CD229	Cell surface; Membrane protein, integral	Q9HBG7	4063	LY9	1q23.3	human	Y651	PHOSPHORYLATION	455757	EIPESPTyENFT___		molecular association, regulation; receptor internalization, altered		Grb2(INDUCES)		5813	1	0	1	Grb2 binding induces CD229 internalization (dominant negative Grb2 (only SH2 domain) inhibits this as does Y651F mutation). 	
DAB1 iso2	Adaptor/scaffold	P97318-2	13131	Dab1		mouse	T385	PHOSPHORYLATION	479416	AMFQGPLtPLATVPG		phosphorylation				11449	1	0	0	inhibits tyrosine phosphorylation	
PLK4	EC 2.7.11.21; KINASE; Kinase, protein; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor)	Q64702	20873	Plk4		mouse	T295	PHOSPHORYLATION	12654001	ATLSTTItASSGTSL		protein degradation; ubiquitination				12525201	1	1	0		
IRAK4	EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, Ser/Thr (non-receptor); Protein kinase, TKL	Q9NWZ3	51135	IRAK4	12q12	human	S346	PHOSPHORYLATION	2045338	FAQTVMTsRIVGTTA	Pkinase	protein conformation; enzymatic activity, induced				25785408; 25785409; 2852672	1	2	1		
PKCD	EC 2.7.10.2; EC 2.7.11.13; KINASE; Kinase, protein; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor)	P28867	18753	Prkcd		mouse	S643	PHOSPHORYLATION	448591	LNEKPQLsFSDKNLI	Pkinase_C	intracellular localization; enzymatic activity, induced				1241; 5201	18	26	69		
IRF7	DNA binding protein; Transcription factor	Q92985	3665	IRF7	11p15.5	human	S479	PHOSPHORYLATION	2868600	SLDSSSLsLCLSSAN		intracellular localization	transcription, induced			8586	3	0	0		
DVL1	Inhibitor protein	P51141	13542	Dvl1		mouse	S142	PHOSPHORYLATION	470074	TGTESMVsHRRERAR		activity, induced	cell differentiation, altered			8945	1	0	0	contributes to B-catenin-dependent Wnt signaling;  mutation of this site inhibits double axis formation in Xenopus embryos	
PKG1	EC 2.7.11.12; KINASE; Kinase, protein; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor)	Q13976	5592	PRKG1	10q11.2	human	S65	PHOSPHORYLATION	452147	TTRAQGIsAEPQTYR		ubiquitination; enzymatic activity, induced				9201007; 8746	4	0	0		
CDK2	EC 2.7.11.22; KINASE; Kinase, protein; Protein kinase, CMGC; Protein kinase, Ser/Thr (non-receptor)	P97377	12566	Cdk2		mouse	T160	PHOSPHORYLATION	447739	GVPVRTYtHEVVTLW	Pkinase	enzymatic activity, induced				6547	36	19	224		
NR1H4 iso2	DNA binding protein; Nuclear receptor	Q96RI1-2	9971	NR1H4	12q23.1	human	S154	PHOSPHORYLATION	4245800	CKGFFRRsITKNAVY	zf-C4	activity, induced; molecular association, regulation	transcription, induced	PGC-1 alpha(INDUCES)		4042525	1	0	0		
Ret	EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Protein kinase, TK; Protein kinase, tyrosine (receptor)	P07949	5979	RET	10q11.2	human	Y791	PHOSPHORYLATION	455479	HPHVIKLyGACSQDG	Pkinase_Tyr	phosphorylation	transcription, altered			5245	2	0	0	STAT3 Y705 phosphorylation	
STXBP4	Vesicle protein	Q9WV89	20913	Stxbp4		mouse	S99	PHOSPHORYLATION	455472	RAKLRSEsPWEIAFI		molecular association, regulation		STX4(DISRUPTS); GLUT4(DISRUPTS)		9382; 5223	3	2	2	Insulin induced Glut 4 translocation to the plasma membrane.	
HSP27	Chaperone; Motility/polarity/chemotaxis	P04792	3315	HSPB1	7q11.23	human	S15	PHOSPHORYLATION	448401	FSLLRGPsWDPFRDW		protein degradation; sumoylation; molecular association, regulation; protein conformation; phosphorylation	apoptosis, altered; apoptosis, inhibited; cytoskeletal reorganization; transcription, altered; cell growth, altered	hnRNP D0(DISRUPTS); HSF1(DISRUPTS)		8471500; 7325707; 21261102; 1959; 1122; 4280504	33	40	27	Raf/MEK/ERK and p38/MKP-1 phosphorylation; triple mutant (S15A/S78A/S82A)	
RhoGDI alpha	Apoptosis; Cell adhesion; Cell development/differentiation; G protein regulator, misc.; Motility/polarity/chemotaxis	P52565	396	ARHGDIA	17q25.3	human	S96	PHOSPHORYLATION	486318	DLTGDLEsFKKQSFV	Rho_GDI	activity, induced	transcription, altered	RhoA(DISRUPTS)		12070	3	0	0	thrombin induced activation 	
IMP-1	Translation	O42254	395953	IGF2BP1		chicken	Y396	PHOSPHORYLATION	458348	SVSGAAPySSFMPPE		molecular association, regulation; activity, inhibited				7417	3	0	0	IMP-1 Y396 phosphorylation interferes with its binding to beta-actin mRNA, thereby promoting beta-actin translation.	
TNFAIP1	DNA replication; Ubiquitin conjugating system	Q13829	7126	TNFAIP1	17q22-q23	human	S280	PHOSPHORYLATION	3195881	SRSQASPsEDEETFE		molecular association, regulation; intracellular localization		PCNA(INDUCES)		26403500	1	4	0	nuclear localization	
MKK4	EC 2.7.12.2; KINASE; Kinase, protein; Protein kinase, STE; Protein kinase, dual-specificity	P45985	6416	MAP2K4	17p12	human	S80	PHOSPHORYLATION	447655	IERLRTHsIESSGKL		activity, inhibited	apoptosis, inhibited			1266	5	6	86		
SUMO1	Nuclear receptor co-regulator; Ubiquitin-like modifier	P63165	7341	SUMO1	2q33	human	K39	SUMOYLATION	2358309	SEIHFKVkMTTHLKK	Rad60-SLD	molecular association, regulation		Daxx(INDUCES)		18837528	2	0	0		
NUP98 iso2	Motility/polarity/chemotaxis; Nucleoporin	P52948-2	4928	NUP98	11p15.5	human	T536	PHOSPHORYLATION	3801389	TPTHYKLtPRPATRV		intracellular localization				18331300	1	5	14	as multiple sites (13PM) mutant 	
CLCN1	Channel, chloride; Membrane protein, integral; Membrane protein, multi-pass	P35523	1180	CLCN1	7q35	human	T891	PHOSPHORYLATION	14645303	LASFRNTtSTRKSTG		activity, induced				14551407	1	0	0		
nNOS	Amino Acid Metabolism - arginine and proline; EC 1.14.13.39; Oxidoreductase	P29476	24598	Nos1		rat	S1412	PHOSPHORYLATION	449830	TNRLRSEsIAFIEES		enzymatic activity, induced				6204	4	0	0	S1412D mutant displayed faster electron transfer out of the reductase domain and intrincis NO synthesis, but slower steady-state NO synthesis.	
VCP	Chaperone; DNA repair; Endoplasmic reticulum; Hydrolase	Q01853	269523	Vcp		mouse	Y805	PHOSPHORYLATION	449060	EDNDDDLyG______		molecular association, regulation		NGLY1(DISRUPTS); TSAd(INDUCES)		8881; 2133208	3	6	277		
GRK1	EC 2.7.11.14; KINASE; Kinase, protein; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor)	P28327	281457	GRK1		cow	T8	PHOSPHORYLATION	2528800	MDFGSLEtVVANSAF		enzymatic activity, induced				2425228	1	0	0	in vitro	
TFCP2	DNA binding protein; Transcription factor	Q12800	7024	TFCP2	12q13	human	S291	PHOSPHORYLATION	7965107	TYVNNSPsPGFNSSH		activity, inhibited; phosphorylation	transcription, inhibited			15235207; 7889913	2	0	0		
HePTP	EC 3.1.3.48; Motility/polarity/chemotaxis; PHOSPHATASE; Protein phosphatase, tyrosine (non-receptor)	P35236	5778	PTPN7	1q32.1	human	S44	PHOSPHORYLATION	448309	RLQERRGsNVALMLD		molecular association, regulation		ERK2(DISRUPTS)		1634	2	5	28		
CDKN2D	Cell cycle regulation; Inhibitor protein	P55273	1032	CDKN2D	19p13	human	S66	PHOSPHORYLATION	6046000	ELLKQGAsPNVQDTS	Ank_2	ubiquitination				5930019	1	0	0	in vitro experiments	
LRP1	Cell surface; Membrane protein, integral; Motility/polarity/chemotaxis; Receptor, misc.	Q07954	4035	LRP1	12q13.3	human	S4517	PHOSPHORYLATION	4769100	LYMGGHGsRHSLAST		molecular association, regulation; receptor internalization, altered		Shc1(INDUCES); GULP1(INDUCES); DAB1(INDUCES)		12482284	1	1	0		
CDK7	EC 2.7.11.22; EC 2.7.11.23; KINASE; Kinase, protein; Nuclear receptor co-regulator; Protein kinase, CMGC; Protein kinase, Ser/Thr (non-receptor)	Q03147	12572	Cdk7		mouse	T170	PHOSPHORYLATION	448306	GSPNRAYtHQVVTRW	Pkinase	molecular association, regulation; enzymatic activity, induced		CCNH(INDUCES)		1664	4	37	85		
LIME1	Adaptor/scaffold; Membrane protein, integral	Q9EQR5	72699	Lime1		mouse	Y261	PHOSPHORYLATION	463811	QGPLENVyESIKEMG		activity, induced; molecular association, regulation		Lyn(INDUCES); Lck(INDUCES)		12482262; 7885	3	1	14		
eIF3-epsilon	EC 3.4.19.12; Translation; Translation initiation	O00303	8665	EIF3F	11p15.4	human	T119	PHOSPHORYLATION	7098400	GAARVIGtLLGTVDK	JAB	molecular association, regulation	translation, altered; apoptosis, induced	eIF3-eta(INDUCES)		6829239	1	1	0		
PXN	Adaptor/scaffold; Cell adhesion; Cytoskeletal protein; Motility/polarity/chemotaxis	Q66H76	360820	Pxn		rat	S126	PHOSPHORYLATION	450227	SFPNKQKsAEPSPTV	Paxillin	intracellular localization				7852	6	14	4	necessary for formation of NGF-induced neurite extensions 	
ARAP3	GTPase activating protein, ARF; GTPase activating protein, Rac/Rho; Motility/polarity/chemotaxis	Q8WWN8	64411	ARAP3	5q31.3	human	Y1403	PHOSPHORYLATION	454957	EELEEPVyEEPVYEE			carcinogenesis, altered; cell motility, altered; cell adhesion, altered			17431531	3	0	0	suppresses peritoneal dissemination of scirrhous gastric carcinoma cells	
Gab1	Adaptor/scaffold; Motility/polarity/chemotaxis	Q13480	2549	GAB1	4q31.21	human	Y317	PHOSPHORYLATION	449581	PPTPGNTyQIPRTFP		molecular association, regulation		RASA1(INDUCES); CDK6(INDUCES)		11387287; 4602	2	5	188	promotes HGF-induced DNA synthesis	
Sam68	RNA binding protein	Q60749	20218	Khdrbs1		mouse	T71	PHOSPHORYLATION	449877	PPLLPPStPGPDATV		activity, induced	translation, altered			2423	1	0	0	regulates splicing	
BARD1	EC 6.3.2.-; EC 6.3.2.19; Ligase; Tumor suppressor; UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase	Q99728	580	BARD1	2q34-q35	human	S148	PHOSPHORYLATION	455770	NSIKMWFsPRSKKVR			cell cycle regulation			5849	2	6	0	resistance to genotoxic stress (mitomycin C)	
C3aR	GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR	Q16581	719	C3AR1	12p13.31	human	S470	PHOSPHORYLATION	27145807	TRSTHCPsNNVISER		receptor internalization, induced; molecular association, regulation	transcription, inhibited	ARRB1(INDUCES)		27132477	1	1	0		
NME2	EC 2.7.13.3; EC 2.7.4.6; KINASE; Kinase, nucleoside diphosphate; Kinase, other; Nucleotide Metabolism - purine; Nucleotide Metabolism - pyrimidine	P22392	4831	NME2	17q21.3	human	H118	PHOSPHORYLATION	474519	QVGRNIIhGSDSVKS	NDK	molecular association, regulation; enzymatic activity, induced		KCNN4(INDUCES)		9307	3	0	0	in vivo and in vitro	
CSFR	EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Protein kinase, TK; Protein kinase, tyrosine (receptor)	P09581	12978	Csf1r		mouse	Y697	PHOSPHORYLATION	451527	DSEGDSSyKNIHLEK	Pkinase_Tyr	activity, induced; molecular association, regulation; enzymatic activity, induced	cell cycle regulation; cell differentiation, altered; cell motility, altered; cytoskeletal reorganization; cell growth, altered	SOCS1(INDUCES); Grb2(INDUCES)		2852655; 3824; 4651302; 3340207; 4914000; 2852611; 1173037; 3955	15	4	32	Y697 mutant fails to induce Mona protein expression. 	
Kit	EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Protein kinase, TK; Protein kinase, tyrosine (receptor)	P10721	3815	KIT	4q11-q12	human	Y936	PHOSPHORYLATION	448019	SESTNHIySNLANCS		protein degradation; molecular association, regulation; receptor internalization, altered		Cbl(INDUCES); APS(INDUCES); GRB7(INDUCES); Grb2(INDUCES)		5409; 8979	4	5	101		
SLK	EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, STE; Protein kinase, Ser/Thr (non-receptor)	Q9H2G2	9748	SLK	10q24.33	human	S348	PHOSPHORYLATION	466944	SDLSIASsEEDKLSQ		enzymatic activity, inhibited				8131	1	15	3	site is critical for v-src dependent modulation of SLK kinase activity	
p47phox	EC 1.-.-.-; Oxidoreductase	P14598	653361	NCF1	7q11.23	human	S370	PHOSPHORYLATION	451730	PAVPPRPsADLILNR	p47_phox_C	activity, induced; molecular association, regulation; intracellular localization; phosphorylation; enzymatic activity, induced		CYBA(INDUCES)		3990; 8704	7	0	0	promotes the phosphorylation of other p47phox PKC sites	
CK2A1	EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor)	P68400	1457	CSNK2A1	20p13	human	T360	PHOSPHORYLATION	449985	SGISSVPtPSPLGPL		enzymatic activity, induced				14511600	2	0	0		
Bik	Apoptosis; Membrane protein, integral; Mitochondrial	Q13323	638	BIK	22q13.31	human	T33	PHOSPHORYLATION	448350	TMEVLGMtDSEEDLD	bcl-2I13	molecular association, regulation	apoptosis, induced	Bcl-2(INDUCES); Bcl-xL(INDUCES)		5312; 1755	2	0	0		
DGKD	EC 2.7.1.107; Kinase, lipid; Lipid Metabolism - glycerolipid; Lipid Metabolism - glycerophospholipid; Motility/polarity/chemotaxis	Q16760	8527	DGKD	2q37.1	human	S66	PHOSPHORYLATION	452137	MLTKQNNsFQRSKRR	PH	intracellular localization				4064	1	0	0	Phosphorylation appears to disrupt translocation of DAGK to the plasma membrane.	
NPHS1	Cell adhesion; Immunoglobulin superfamily; Membrane protein, integral	O60500	4868	NPHS1	19q13.1	human	T1125	PHOSPHORYLATION	18507017	QWTGERDtQSSTVST		molecular association, regulation		ARRB2(INDUCES)		18410831	1	0	0	PICK1 and PKCa are also in this complex	
p63 iso2	DNA binding protein; Transcription factor	Q9H3D4-2	8626	TP63	3q28	human	S66	PHOSPHORYLATION	451600	SSTFDALsPSPAIPS		protein degradation	cell growth, inhibited			27257046	1	0	0	Anti-clonogenic effects of TGFB require S66,68 phosphorylation.	
Cdc25B	EC 3.1.3.48; Motility/polarity/chemotaxis; Nuclear receptor co-regulator; PHOSPHATASE; Protein phosphatase, dual-specificity	P30306	12531	Cdc25b		mouse	S149	PHOSPHORYLATION	7998663	FTIKRFRsLPVRLLE	M-inducer_phosp	intracellular localization	cell cycle regulation			23260311; 18021017	3	5	21		
Daxx	Apoptosis; Nuclear receptor co-regulator; Transcription, coactivator/corepressor	Q9UER7	1616	DAXX	6p21.3	human	S178	PHOSPHORYLATION	1189200	AENTASQsPRTRGSR	Daxx	protein degradation; molecular association, regulation	apoptosis, inhibited	Pin1(INDUCES)		1172814	1	7	2		
CNR1	GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR	P47746	12801	Cnr1		mouse	T468	PHOSPHORYLATION	22342301	TMSVSTDtSAEAL__		receptor desensitization, induced				21686207	1	0	0		
TSC2 iso2	Cell cycle regulation; GTPase activating protein, misc.; Nuclear receptor co-regulator; Tumor suppressor	P49816-2	24855	Tsc2		rat	S1342	PHOSPHORYLATION	450216	FQPSQPLsKSSSSPE		phosphorylation	apoptosis, altered; cell growth, altered			2902	2	0	1		
Fyn	EC 2.7.10.2; KINASE; Kinase, protein; Protein kinase, TK; Protein kinase, tyrosine (non-receptor)	Q62844	25150	Fyn		rat	Y531	PHOSPHORYLATION	447883	FTATEPQyQPGENL_		enzymatic activity, inhibited				9689604	15	10	1039		
CACNA1C iso4	Channel, calcium; Membrane protein, integral; Membrane protein, multi-pass	P15381-4		CACNA1C		rabbit	S1512	PHOSPHORYLATION	460572	DYLTRDWsILGPHHL		activity, induced				8157	4	0	0		
survivin	Apoptosis	O15392	332	BIRC5	17q25	human	T48	PHOSPHORYLATION	18451300	AGFIHCPtENEPDLA	BIR	molecular association, regulation; intracellular localization	cell cycle regulation; apoptosis, altered	Borealin(DISRUPTS)		18410858	1	0	0		
STMN1	Cytoskeletal protein	P16949	3925	STMN1	1p36.11	human	S16	PHOSPHORYLATION	448554	KELEKRAsGQAFELI	Stathmin	molecular association, regulation; activity, inhibited	cell cycle regulation; apoptosis, altered; cytoskeletal reorganization	TUBA4A(DISRUPTS); TUBA1A(DISRUPTS); TUBB(DISRUPTS)		5191; 7742; 2797; 7802; 7543504; 8835; 2798	23	46	53	in vitro	
WT1	C2H2-type zinc finger protein; DNA binding protein; Transcription factor	P19544	7490	WT1	11p13	human	S393	PHOSPHORYLATION	451121	KTCQRKFsRSDHLKT	Ofd1_CTDD; zf-H2C2_2		transcription, altered			3323	1	0	0	Phosphorylation of S365 and S393 inhibited WT1 DNA-binding, and thereby decreased WT1 transcriptional repression activity.	
RFC1	DNA replication	P35251	5981	RFC1	4p14-p13	human	T506	PHOSPHORYLATION	2915401	KESKLERtPQKNVQG		molecular association, regulation		PCNA(DISRUPTS)		8775	1	4	6		
FOXA2	DNA binding protein; Transcription factor	Q9Y261	3170	FOXA2	20p11	human	S111	PHOSPHORYLATION	22825101	PHLSPSLsPLGGQAA	Fork_head_N		carcinogenesis, induced; cell growth, induced; transcription, inhibited; signaling pathway regulation			22723910	1	1	0		
mGluR1	GPCR, family 3; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR	P23385	24414	Grm1		rat	T871	PHOSPHORYLATION	4713375	KLPCRSNtFLNIFRR		receptor desensitization, induced; molecular association, regulation		CAMK2A(INDUCES)		27623413	1	3	3		
C/EBP-beta	DNA binding protein; Motility/polarity/chemotaxis; Transcription factor	P21272	24253	Cebpb		rat	Y109	PHOSPHORYLATION	13373503	KKPSDYGyVSLGRAG		molecular association, regulation	cell growth, induced; transcription, induced		DNA(INDUCES)	13354731	1	2	1		
Cdc25A	EC 3.1.3.48; Motility/polarity/chemotaxis; PHOSPHATASE; Protein phosphatase, dual-specificity	P30304	993	CDC25A	3p21	human	T507	PHOSPHORYLATION	450483	KFRTKSRtWAGEKSK		molecular association, regulation; enzymatic activity, inhibited; activity, inhibited	apoptosis, altered	14-3-3 beta(INDUCES); CCNA1(DISRUPTS); CDK2(DISRUPTS); CDK1(DISRUPTS); CCNB1(DISRUPTS)		14664800; 3111	4	2	0		
TH iso3	Amino Acid Metabolism - tyrosine; EC 1.14.16.2; Endoplasmic reticulum; Mitochondrial; Oxidoreductase; Vesicle protein	P07101-3	7054	TH	11p15.5	human	S31	PHOSPHORYLATION	448544	KQAEAIMsPRFIGRR	TOH_N	phosphorylation; enzymatic activity, induced				11270019; 7324135; 7484	32	5	0	stimulates phosphorylation of S40 in TH iso2 ; absence of S31 and S40 in an alternative spliced variant lacking exon 3 that has reduced enzymatic activity in vitro	
IL21R	Membrane protein, integral; Receptor, cytokine	Q9JHX3	60504	Il21r		mouse	Y510	PHOSPHORYLATION	475069	DEGPPRSyLRQWVVR		phosphorylation	cell growth, altered			9299	1	0	0		
ZO2	Adaptor/scaffold; Motility/polarity/chemotaxis	Q95168	403854	TJP2		dog	S369	PHOSPHORYLATION	9730701	QLVVLRDsKQTLINI		intracellular localization				9689605	1	0	0	critical for the departure of ZO2 from the nucleus 	
mGluR5	GPCR, family 3; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR	P31424	24418	Grm5		rat	S839	PHOSPHORYLATION	455778	VRSAFTTsTVVRMHV		activity, induced				5806	1	5	2	Phosphorylation increases calcium oscillations.  Not T840 as believed in a previous paper (mutation of T840D decreases the phosphorylation of S839 though).	
CARD11	Adaptor/scaffold	Q6KAS3	108723	Card11		mouse	S649	PHOSPHORYLATION	457638	NLMLRKFsLERPFRP		activity, inhibited	apoptosis, altered; cell growth, altered			11419355	2	1	0		
NFAT1	DNA binding protein; Transcription factor	Q60591	18019	Nfatc2		mouse	S173	PHOSPHORYLATION	447840	PLCLSPAsSGSSASF			transcription, inhibited			1188	0	1	0		
Cdc6	Cell cycle regulation	Q99741	990	CDC6	17q21.3	human	S74	PHOSPHORYLATION	450915	TPHLPPCsPPKQGKK		protein stabilization; intracellular localization	cell cycle regulation			27258204; 7270; 3156	6	6	1		
SgK307	Cancer Testis Antigen (CTA); KINASE; Kinase, protein; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor)	Q8IWB6	56155	TEX14	17q22	human	T728	PHOSPHORYLATION	25158901	NLNNMSTtEEYLISK		molecular association, regulation; intracellular localization		PLK1(INDUCES)		25082834	1	0	0		
NUDE1	Cell cycle regulation; Cytoskeletal protein; Microtubule binding protein	Q9NXR1	54820	NDE1	16p13.11	human	T131	PHOSPHORYLATION	20609200	LERAKRAtIMSLEDF	DUF2009; Striatin	molecular association, regulation; protein conformation	cytoskeletal reorganization	NDEL1(INDUCES); PAFAH1B1(DISRUPTS)		20540214	1	0	0	T131 phoshomimetic mutant inhibits neurite extension.	
polycystin 2	Channel, cation; Membrane protein, integral; Membrane protein, multi-pass	Q13563	5311	PKD2	4q22.1	human	S812	PHOSPHORYLATION	451598	FPRSLDDsEEDDDED		activity, induced				3732	3	11	7	Mutation of S812 to alanine results in a reduced calcium-dependence of channel activity.	
ghrelin	Apoptosis; Cell cycle regulation; Cell development/differentiation; Secreted; Secreted, signal peptide	Q9UBU3	51738	GHRL	3p26-p25	human	S41	PHOSPHORYLATION	2235100	RVQQRKEsKKPPAKL	Motilin_ghrelin	intracellular localization; protein conformation				2195464	1	0	0	disrupts ghrelin structure and its binding to membranes	
PML	Transcription factor; Tumor suppressor; Ubiquitin conjugating system	P29590	5371	PML	15q22	human	S560	PHOSPHORYLATION	6835504	EERVVVIsSSEDSDA	DUF3583	molecular association, regulation		SUMO1(INDUCES)		6829202	2	3	0		
SRC-3	ACETYLTRANSFERASE; Acetyltransferase; EC 2.3.1.48; Motility/polarity/chemotaxis; Nuclear receptor co-regulator; Transcription, coactivator/corepressor	Q9Y6Q9	8202	NCOA3	20q12	human	T24	PHOSPHORYLATION	454110	KRKLPCDtPGQGLTC		molecular association, regulation		ER-alpha(DISRUPTS)		4214	3	0	0	Mutations to alanine inhibited protein-protein interactions. 	
PRDX6	Amino Acid Metabolism - phenylalanine; EC 1.11.1.15; EC 1.11.1.7; EC 1.11.1.9; EC 3.1.1.-; Energy Metabolism - methane; Oxidoreductase; Phospholipase	O35244	94167	Prdx6		rat	T177	PHOSPHORYLATION	3823356	TASNPVAtPVDWKKG	1-cysPrx_C	enzymatic activity, induced				6331311	2	2	9	in vitro	
TAP	Motility/polarity/chemotaxis; Vesicle protein	O60763	8615	USO1	4q21.1	human	S942	PHOSPHORYLATION	450465	EEEDELEsGDQEDED	Uso1_p115_C	intracellular localization				12482228	3	36	41	regulates association with Golgi membrane 	
IKKE	EC 2.7.11.10; Inhibitor protein; KINASE; Kinase, protein; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor)	Q14164	9641	IKBKE	1q32.1	human	S172	PHOSPHORYLATION	447631	DDDEKFVsVYGTEEY	Pkinase	enzymatic activity, induced				1328	3	1	0		
PKCB	EC 2.7.11.13; KINASE; Kinase, protein; Motility/polarity/chemotaxis; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor)	EDL17280	18751	Prkcb		mouse	Y629	PHOSPHORYLATION	455926	NEFAGFSyTNPEFVI	Pkinase_C	molecular association, regulation		Grb2(INDUCES)		5666	1	0	0		
SGO1	Cell cycle regulation	Q5FBB7	151648	SGOL1	3p24.3	human	S507	PHOSPHORYLATION	486242	TDLCFLNsPIFKQKK			chromatin organization, altered			12089	1	5	5	required for proper association between the kinetochore and spindle microtubules	
LIG1	DNA repair; EC 6.5.1.1; Ligase	P18858	3978	LIG1	19q13.2-q13.3	human	S76	PHOSPHORYLATION	449246	EEEDEALsPAKGQKP		molecular association, regulation; intracellular localization	cell growth, altered	RFC1(INDUCES); Rad17(DISRUPTS)		7072901; 8424	6	26	8	regulates DNA replication and repair	
NFAT4	DNA binding protein; Transcription factor	Q12968	4775	NFATC3	16q22.2	human	T204	PHOSPHORYLATION	11507601	NEAAARFtLGSPLTS		intracellular localization				10274612	1	0	0	cytoplasmic localization (inhibition of nuclear localization)	
Abi-1	Adaptor/scaffold; Motility/polarity/chemotaxis	Q8IZP0	10006	ABI1	10p11.2	human	S225	PHOSPHORYLATION	1983922	ARLGSQHsPGRTASL		molecular association, regulation	cell motility, altered; cytoskeletal reorganization			18668222	1	24	89	regulates WRC (WAVE2 regulatory complex) interaction with Arp2/3 and lamellipodial protrusion	
MKK4	EC 2.7.12.2; KINASE; Kinase, protein; Protein kinase, STE; Protein kinase, dual-specificity	P45985	6416	MAP2K4	17p12	human	S257	PHOSPHORYLATION	447654	ISGQLVDsIAKTRDA	Pkinase	enzymatic activity, induced				2852638	11	8	32		
LPP	Adaptor/scaffold; Cytoskeletal protein; Motility/polarity/chemotaxis	Q8BFW7	210126	Lpp		mouse	Y298	PHOSPHORYLATION	449713	TSNQGRYyEPYYAAG			cell cycle regulation; cell motility, altered			2790302	0	4	45		
Ikaros	C2H2-type zinc finger protein; DNA binding protein; Transcription factor	Q03267	22778	Ikzf1		mouse	S167	PHOSPHORYLATION	451355	LRHIKLHsGEKPFKC	zf-H2C2_2	intracellular localization				3560	2	1	0		
ARRB1	Adaptor/scaffold	P29066	25387	Arrb1		rat	Y54	PHOSPHORYLATION	458023	YLKERRVyVTLTCAF	Arrestin_N	molecular association, regulation; receptor internalization, altered		AP3M1(DISRUPTS)		11955	1	1	1	decreases beta 2 adrenergic receptor internalization	
EpoR	EC 2.7.10.2; Membrane protein, integral; Receptor, cytokine	P19235	2057	EPOR	19p13.3-p13.2	human	Y468	PHOSPHORYLATION	451266	DSGISTDySSGDSQG			apoptosis, inhibited			8833	2	0	0		
GABRA4	Channel, chloride; Channel, ligand-gated; Membrane protein, integral; Membrane protein, multi-pass	P48169	2557	GABRA4	4p12	human	S474	PHOSPHORYLATION	17390700	KASVGSAsTRHVFGS	Neur_chan_memb	protein stabilization; intracellular localization				15754900	1	0	0	increases receptor cell surface expression	
POLD3	DNA replication; Nucleotide Metabolism - purine; Nucleotide Metabolism - pyrimidine	Q15054	10714	POLD3	11q14	human	S458	PHOSPHORYLATION	3196808	GKANRQVsITGFFQR	CDC27	molecular association, regulation; enzymatic activity, altered		PCNA(DISRUPTS)		22723945	1	7	18	S458D mutation results in a loss of POLD3 (aka p68) processivity	
diaphanous 2 iso4	Cytoskeletal protein; Motility/polarity/chemotaxis	Q17R91	1730	DIAPH2	Xq21.33	human	T882	PHOSPHORYLATION	18707507	KSADQKTtLLHFIAD	FH2; DUF724		cell cycle regulation; chromatin organization, altered; cytoskeletal reorganization			18668219	1	1	0	mutation of this site disrupts metaphase chromosome alignment	
PXR	DNA binding protein; Nuclear receptor	O75469	8856	NR1I2	3q12-q13.3	human	S208	PHOSPHORYLATION	9730703	QVRKDLCsLKVSLQL		molecular association, regulation	transcription, altered	N-CoR1(INDUCES); Fgr(DISRUPTS); RXRA(DISRUPTS)		9689411	1	0	0	inhibits transcription	
Kir6.2	Channel, potassium; Membrane protein, integral; Membrane protein, multi-pass	Q61743	16514	Kcnj11		mouse	T341	PHOSPHORYLATION	2103600	GNTIKVPtPLCTARQ	IRK	activity, induced; protein conformation				1968364	1	0	0		
APP iso2	Apoptosis; Cell surface; Membrane protein, integral; Receptor, misc.; Transcription factor	P12023-2	11820	App		mouse	Y682	PHOSPHORYLATION	448202	SKMQQNGyENPTYKF	APP_amyloid	molecular association, regulation		Shc1(INDUCES); Grb2(INDUCES)		3752	9	8	836		
hnRNP C1/C2	RNA binding protein; RNA splicing; Spliceosome	P07910	3183	HNRNPC	14q11.2	human	S260	PHOSPHORYLATION	448833	SEGGADDsAEEGDLL	Alpha-2-MRAP_C; DUF2422; RP-C_C	molecular association, regulation			RNA(NOT_REPORTED)	4574	2	40	87		
GH receptor	Membrane protein, integral; Receptor, cytokine	P16310	25235	Ghr		rat	Y338	PHOSPHORYLATION	455508	DNYKPDFyNDDSWVE	GHBP	molecular association, regulation		SOCS3(INDUCES)		5357	2	0	0		
PML	Transcription factor; Tumor suppressor; Ubiquitin conjugating system	P29590	5371	PML	15q22	human	S403	PHOSPHORYLATION	3189643	AAVSKKAsPEAASTP	DUF3583		carcinogenesis, altered			15675501	1	12	40		
galectin-3	Cell surface; Extracellular matrix; Motility/polarity/chemotaxis	P17931	3958	LGALS3	14q22.3	human	Y107	PHOSPHORYLATION	14823408	AYPATGPyGAPAGPL			cell motility, altered			14790301	3	0	0	regulates cell morphology	
SREBP-1	DNA binding protein; Membrane protein, integral; Membrane protein, multi-pass; Transcription factor	P36956	6720	SREBF1	17p11.2	human	T426	PHOSPHORYLATION	467200	TEVEDTLtPPPSDAG		protein degradation; molecular association, regulation; phosphorylation	transcription, induced	FBXW7(INDUCES)		6331305; 8159	3	0	0		
PKD1	Autophagy; EC 2.7.11.13; KINASE; Kinase, protein; Motility/polarity/chemotaxis; Protein kinase, CAMK; Protein kinase, Ser/Thr (non-receptor)	Q15139	5587	PRKD1	14q11	human	S219	PHOSPHORYLATION	455755	VSTIRTSsAELSTSA		molecular association, regulation		14-3-3 beta(INDUCES)		5785	1	2	0		
Smad3	DNA binding protein; Nuclear receptor co-regulator; Transcription factor	P84022	4088	SMAD3	15q22.33	human	T179	PHOSPHORYLATION	451177	PQSNIPEtPPPGYLS		molecular association, regulation; intracellular localization; activity, inhibited	cell cycle regulation; transcription, inhibited; transcription, altered; cell growth, altered	NEDD4L(INDUCES); Pin1(INDUCES)		6945; 15658700; 12343103; 3386; 11419347; 12066001; 4092	10	0	0		
NPM-ALK	Kinase, protein; Protein kinase, TK; Protein kinase, tyrosine (receptor)	AAA58698		NPM/ALK		human	S135	PHOSPHORYLATION	27275118	AMQMELQsPEYKLSK	Nucleoplasmin	phosphorylation	carcinogenesis, altered; cell growth, altered			17482910	1	1	0		
VASP	Cytoskeletal protein; Motility/polarity/chemotaxis	P70460	22323	Vasp		mouse	S153	PHOSPHORYLATION	448379	EHMERRVsNAGGPPA		molecular association, regulation		Abl iso2(INDUCES)		5392	35	4	0		
caldesmon	Actin binding protein	P12957	373965	CALD1		chicken	S631	PHOSPHORYLATION	15668100	AHTTAVVsKIDSRLE	Caldesmon	molecular association, regulation		caldesmon(DISRUPTS)		15571612	0	1	0	enhances effect of S672 and S702  phosphorylation to weaken interaction	
BAF	DNA binding protein	O75531	8815	BANF1	11q13.1	human	S4	PHOSPHORYLATION	458302	____MTTsQKHRDFV	BAF	molecular association, regulation; intracellular localization		lamin A/C(DISRUPTS)	DNA(DISRUPTS)	7369; 12619500	3	6	0		
NMDAR2A	Channel, ligand-gated; Membrane protein, integral; Membrane protein, multi-pass	P35436	14811	Grin2a		mouse	Y1325	PHOSPHORYLATION	458211	RLLEGNLyGSLFSVP	NMDAR2_C	activity, induced; phosphorylation				11262505	2	0	86	mutation of this site increases phosphorylation of T34 of DARPP-32	
PDK1	EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor)	O15530	5170	PDPK1	16p13.3	human	S396	PHOSPHORYLATION	448582	SSSSSSHsLSASDTG		intracellular localization	transcription, altered			5208	4	1	0	regulates nuclear accumulation and inhibits transcription through FOXO3a	
NEUROD1	DNA binding protein; Transcription factor	Q60867	18012	Neurod1		mouse	S274	PHOSPHORYLATION	465680	PSFDGPLsPPLSING	Neuro_bHLH	molecular association, regulation	transcription, induced	E2A iso2(INDUCES)		8116	2	0	0		
NPM1	RNA binding protein; Translation	P06748	4869	NPM1	5q35.1	human	T199	PHOSPHORYLATION	448515	VKKSIRDtPAKNAQK	Nop14; TFIIF_alpha	acetylation; molecular association, regulation; ubiquitination; activity, inhibited	transcription, altered		RNA(DISRUPTS)	15658715; 3335907; 2056; 14146307	16	11	26	increases inhibition GCN5 histone acetylase and transactivation activity 	
ADD2	Cytoskeletal protein; Motility/polarity/chemotaxis	P35612	119	ADD2	2p13.3	human	S693	PHOSPHORYLATION	454590	SVTSGPMsPEGSPSK		phosphorylation				23940900	1	9	0	CDK5 primes sites for phosphorylation by GSK3B	
HDAC2	DEACETYLASE; Deacetylase; EC 3.5.1.98; Nuclear receptor co-regulator; Transcription, coactivator/corepressor	Q92769	3066	HDAC2	6q21	human	S411	PHOSPHORYLATION	13373500	KRISIRAsDKRIACD		molecular association, regulation; acetylation; enzymatic activity, inhibited		p53(INDUCES); HDAC1(INDUCES)		13354700	2	1	0		
BMAL1	DNA binding protein; Transcription factor	Q9I8T7	374115	ARNTL		chicken	T534	PHOSPHORYLATION	448633	SPLNITStPPPDTSS		activity, inhibited	transcription, inhibited			3048	2	1	0		
CSRP2	Cell development/differentiation	Q16527	1466	CSRP2	12q21.1	human	Y62	PHOSPHORYLATION	470027	EIYCKSCyGKKYGPK	LIM	intracellular localization	transcription, altered			8850	1	0	0	Nuclear translocation.	
SYN1	Vesicle protein	P09951	24949	Syn1		rat	S603	PHOSPHORYLATION	450236	AGPIRQAsQAGPGPR		intracellular localization				11424214	16	7	7		
STAT3	DNA binding protein; Motility/polarity/chemotaxis; Nuclear receptor co-regulator; Transcription factor	P42227	20848	Stat3		mouse	S727	PHOSPHORYLATION	448191	NTIDLPMsPRTLDSL		activity, induced; molecular association, regulation; intracellular localization; phosphorylation	transcription, induced; transcription, altered; cell growth, altered	PDGFRA(INDUCES); ANXA1(INDUCES); Pin1(INDUCES)	DNA(INDUCES); DNA(DISRUPTS)	1929900; 3601; 5410113; 1965400; 980900; 1828; 2422209; 6280; 4785; 5704	121	22	66		
Cdc25A	EC 3.1.3.48; Motility/polarity/chemotaxis; PHOSPHATASE; Protein phosphatase, dual-specificity	P30304	993	CDC25A	3p21	human	S279	PHOSPHORYLATION	449129	VLKRPERsQEESPPG	M-inducer_phosp	protein degradation				2163	1	0	0		
Rb-like 2	Transcription, coactivator/corepressor	Q08999	5934	RBL2	16q12.2	human	S413	PHOSPHORYLATION	449724	VRYIKENsPCVTPVS		molecular association, regulation	cell cycle regulation	E2F4(DISRUPTS)		1200; 5981	3	7	1		
FAK	EC 2.7.1.112; EC 2.7.10.2; KINASE; Kinase, protein; Protein kinase, TK; Protein kinase, tyrosine (non-receptor)	Q00944	396416	PTK2		chicken	S722	PHOSPHORYLATION	447962	PSRPGYPsPRSSEGF		molecular association, regulation; enzymatic activity, inhibited	cell motility, altered	PPP1CA(INDUCES); P130Cas(DISRUPTS)		1082; 6344	7	11	0		
H1R	GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR	P35367	3269	HRH1	3p25	human	S396	PHOSPHORYLATION	453404	FTWKRLRsHSRQYVS	7tm_1	receptor desensitization, altered; activity, inhibited				4674; 4121	2	0	0	S396 phosphorylation had an inhibitory effect on S398-mediated receptor downregulation.	
IKK-gamma	Adaptor/scaffold; Protein kinase, regulatory subunit	O88522	16151	Ikbkg		mouse	S369	PHOSPHORYLATION	448798	LPAPAHHsFHLALSN		activity, inhibited	transcription, altered			1957	3	2	6	NFKB reporter assays	
MYBPC3	Myosin binding protein	Q14896	4607	MYBPC3	11p11.2	human	S275	PHOSPHORYLATION	471079	LSAFRRTsLAGGGRR			cytoskeletal reorganization			12662610	13	4	14	regulation of cardiac myofilament function	
PSEN1	Cell surface; EC 3.4.23.-; Membrane protein, integral; Membrane protein, multi-pass; Mitochondrial; Protease	P49768	5663	PSEN1	14q24.3	human	S346	PHOSPHORYLATION	450179	EWEAQRDsHLGPHRS	Presenilin		apoptosis, inhibited			2810	1	0	0	Phosphorylation at S346 regulates the caspase-mediated cleavage of PS1 and inhibits progression of apoptosis.	
PFKFB2	Carbohydrate Metabolism - fructose and mannose; EC 2.7.1.105; EC 3.1.3.46; Kinase, other; Motility/polarity/chemotaxis; Phosphatase (non-protein)	Q9JJH5	24640	Pfkfb2		rat	S469	PHOSPHORYLATION	448460	PVRMRRNsFTPLSSS		enzymatic activity, induced				1485	9	23	319		
pleckstrin	Lipid binding protein	P08567	5341	PLEK	2p13.3	human	S117	PHOSPHORYLATION	451306	ARKSTRRsIRLPETI		activity, induced				11484402	2	7	146		
PITX2	Cell cycle regulation; DNA binding protein; Motility/polarity/chemotaxis; Transcription factor	P97474	18741	Pitx2		mouse	T90	PHOSPHORYLATION	25790902	KRQRRQRtHFTSQQL	XRCC4; Homeobox	molecular association, regulation	cell growth, inhibited; cell differentiation, induced; RNA stability, inhibited	14-3-3 zeta(INDUCES); HuR(DISRUPTS)		25785424	1	0	0		
CK1E	EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, CK1; Protein kinase, Ser/Thr (non-receptor)	P49674	1454	CSNK1E	22q13.1	human	T325	PHOSPHORYLATION	453417	GQLRGSAtRALPPGP		enzymatic activity, inhibited				8419; 2331	2	0	1	some subset of these 8 sites	
SMARCC2	DNA binding protein; Transcription, coactivator/corepressor	Q8TAQ2	6601	SMARCC2	12q13.2	human	S969	PHOSPHORYLATION	15707400	PPALPPGsQPIPPTG		molecular association, regulation	chromatin organization, altered	MCPH1(INDUCES)		15706900	1	0	0	interaction enhanced after DNA damage with ionizing radiation	
Lyn	EC 2.7.10.2; KINASE; Kinase, protein; Protein kinase, TK; Protein kinase, tyrosine (non-receptor)	P07948	4067	LYN	8q13	human	Y508	PHOSPHORYLATION	447624	YTATEGQyQQQP___		enzymatic activity, inhibited				4914024	11	25	1558		
TRHR	GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR	Q01717	25570	Trhr		rat	T371	PHOSPHORYLATION	465593	STELDDItVTDTYVS		receptor internalization, altered				8037	3	0	0	S383, T365, T371 are important for the receptor internalization	
AIP	Transcription, coactivator/corepressor	O00170	9049	AIP	11q13.3	human	S132	PHOSPHORYLATION	10888702	AQMREHSsLGHADLD		molecular association, regulation		HSP90A(INDUCES)		10167104	1	0	0		
Fyn	EC 2.7.10.2; KINASE; Kinase, protein; Protein kinase, TK; Protein kinase, tyrosine (non-receptor)	P06241	2534	FYN	6q21	human	Y420	PHOSPHORYLATION	447882	RLIEDNEyTARQGAK	Pkinase_Tyr	molecular association, regulation		STEP(INDUCES)		5361	19	55	3061		
BRAF	EC 2.7.1.37; EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, Ser/Thr (non-receptor); Protein kinase, TKL	F1M9C3	114486	Braf		rat	S463	PHOSPHORYLATION	447803	PQRERKSsSSSSSTE		enzymatic activity, inhibited; enzymatic activity, induced	cell differentiation, altered			9001	6	0	32	 activates the B3-Raf9b isoform ; inhibits activity of the B2-Raf8b isoform	
IFNAR1	Membrane protein, integral; Receptor, cytokine	P17181	3454	IFNAR1	21q22.11	human	Y466	PHOSPHORYLATION	450029	VFLRCINyVFFPSLK		protein stabilization; molecular association, regulation; receptor internalization, inhibited; phosphorylation	transcription, induced	STAT2(INDUCES); STAT1(INDUCES)		3449; 2576; 8564; 27257019	3	0	0	virally induced and negatively regulated by PTP1B dephosphorylatyion of human Y466 ; STAT2 also binds to IFNAR2 in a phosphorylation independent manner with 6-fold higher affinity. Y481 is a weak docking site to STAT2.   	
myocardin	Cell development/differentiation; Transcription factor	Q8VIM5	214384	Myocd		mouse	S859	PHOSPHORYLATION	10791202	ELLPGPLsPMHAQLS		molecular association, regulation	transcription, inhibited	CBP(DISRUPTS)		10353931	1	0	0		
PLCG2	Carbohydrate Metabolism - inositol phosphate; EC 3.1.4.11; Motility/polarity/chemotaxis; Phospholipase	P24135	29337	Plcg2		rat	Y1197	PHOSPHORYLATION	447938	LESEEELySSCRQLR		enzymatic activity, induced				2451	3	1	81		
PYGM	Carbohydrate Metabolism - starch and sucrose; EC 2.4.1.1; Endoplasmic reticulum; Phosphorylase; Transferase	P00489	100008972	PYGM		rabbit	S15	PHOSPHORYLATION	449838	QEKRKQIsVRGLAGV		enzymatic activity, induced				6831; 2384	4	4	0		
ERK5	EC 2.7.11.24; KINASE; Kinase, protein; Protein kinase, CMGC; Protein kinase, Ser/Thr (non-receptor)	Q9WVS8	23939	Mapk7		mouse	S760	PHOSPHORYLATION	14561007	PQDGQADsASLSASL			transcription, altered			14551427	1	1	0		
HIF1A	Autophagy; DNA binding protein; Transcription factor	Q16665	3091	HIF1A	14q23.2	human	S247	PHOSPHORYLATION	15434302	KTFLSRHsLDMKFSY		molecular association, regulation; activity, inhibited	cell cycle regulation; carcinogenesis, altered; transcription, inhibited	ARNT(DISRUPTS)		15278816	1	0	0		
NFAT1	DNA binding protein; Transcription factor	Q60591	18019	Nfatc2		mouse	S56	PHOSPHORYLATION	455327	HKAISSPsGLAYPDD			transcription, induced			1188	0	1	0		
axin 1	Adaptor/scaffold	O35625	12005	Axin1		mouse	S485	PHOSPHORYLATION	451092	MRTPGCQsPGPGHRS	Axin_b-cat_bind	activity, induced				3178	2	4	5	Phosphorylation plays a role in the activation of axin to modulate Lef/Tcf signaling.  Phosphorylation by GSK3beta also leads to increased direct binding of beta-catenin in vitro.	
LEPR	Membrane protein, integral; Receptor, cytokine	P48357	3953	LEPR	1p31	human	Y1141	PHOSPHORYLATION	448434	SKKTFASyMPQFQTC			signaling pathway regulation			15571610	15	0	0	mediates STAT3 phosphorylation and FZD1 expression	
SLAP-130	Adaptor/scaffold	O15117	2533	FYB	5p13.1	human	Y571	PHOSPHORYLATION	454079	TTAVEIDyDSLKLKK	Ycf1		cell motility, altered			15020906	1	19	794	promotes cell migration	
PDE6G	EC 3.1.4.17; EC 3.1.4.35; Nucleotide Metabolism - purine; Phosphodiesterase	P09174	18588	Pde6g		mouse	T62	PHOSPHORYLATION	449335	PGMEGLGtDITVICP	PDE6_gamma	activity, induced; molecular association, regulation; phosphorylation		GRK2(INDUCES)		2189; 2196	2	0	0	leads to greater phospho-ERK; increases ERK phosphorylation	
RASSF1 iso2	Tumor suppressor	Q9NS23-2	11186	RASSF1	3p21.3	human	T202	PHOSPHORYLATION	483999	GTSVRRRtSFYLPKD	RA	protein degradation; molecular association, regulation; ubiquitination	cell cycle regulation	TUBA1A(DISRUPTS)		25227600; 12007	3	2	1	APC/C-dependent ubiquitination of RASSF1	
AML3	DNA binding protein; Transcription factor	Q13950	860	RUNX2	6p21	human	S465	PHOSPHORYLATION	460684	MVPGGDRsPSRMLPP	RunxI		cell cycle regulation; transcription, altered; cell growth, altered			7738	4	0	0		
HEFL	Adaptor/scaffold	Q9NQ75	57091	CASS4	20q13.31	human	Y350	PHOSPHORYLATION	458181	QNTKPNIyDIPKATS		molecular association, regulation		Arg(NOT_REPORTED)		27932900	0	2	344		
eIF2-beta	Translation; Translation initiation	P20042	8894	EIF2S2	20q11.2	human	S67	PHOSPHORYLATION	450072	DTRKKDAsDDLDDLN			translation, altered; cell growth, altered			7655	3	19	0		
MARK3	EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, CAMK; Protein kinase, Ser/Thr (non-receptor)	P27448	4140	MARK3	14q32.3	human	T211	PHOSPHORYLATION	450314	TVGGKLDtFCGSPPY	Pkinase	enzymatic activity, induced				2942	2	25	27		
TCF7L2	Apoptosis; Cell cycle regulation; Cell development/differentiation; DNA binding protein; Motility/polarity/chemotaxis; Transcription factor	Q9NQB0	6934	TCF7L2	10q25.3	human	T201	PHOSPHORYLATION	11499003	PHHVHPLtPLITYSN	CTNNB1_binding	molecular association, regulation			DNA(DISRUPTS)	10294002	1	0	0	Beta-catenin-TCF7L2 complex DNA binding	
Kv1.3	Channel, potassium; Membrane protein, integral; Membrane protein, multi-pass	P22001	3738	KCNA3	1p13.3	human	Y161	PHOSPHORYLATION	3820926	PSFDAILyYYQSGGR	K_tetra	activity, inhibited				6331318	1	0	0		
ANXA2	Calcium-binding protein; Lipid binding protein; Motility/polarity/chemotaxis	P07355	302	ANXA2	15q22.2	human	S12	PHOSPHORYLATION	450880	HEILCKLsLEGDHST		molecular association, regulation; intracellular localization		S100A10(DISRUPTS)		3039; 17431540; 3177	5	8	1		
DDR2	EC 2.7.1.112; EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Protein kinase, TK; Protein kinase, tyrosine (receptor)	Q16832	4921	DDR2	1q23.3	human	Y740	PHOSPHORYLATION	456862	RNLYSGDyYRIQGRA	Pkinase_Tyr	phosphorylation				6843	1	5	392	Stimulates autophosphorylation.  Autophosphorylation induces Shc binding (site not determined).	
HCRTR1	GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR	O43613	3061	HCRTR1	1p33	human	Y358	PHOSPHORYLATION	2063600	SAANPIIyNFLSGKF	7tm_1; TM		apoptosis, induced			1968331	1	0	0	apoptosis is inhibited in cells transfected with dnSHP-2 cDNA or treated with PAO	
SOX2	Cell development/differentiation; DNA binding protein; Transcription factor	P48432	20674	Sox2		mouse	K75	ACETYLATION	8537503	MHNSEISkRLGAEWK	HMG_box	protein degradation; molecular association, regulation; ubiquitination; intracellular localization	transcription, altered	exportin 1(INDUCES)		8164801	1	1	1	promotes nuclear export	
LIME1	Adaptor/scaffold; Membrane protein, integral	Q9EQR5	72699	Lime1		mouse	Y242	PHOSPHORYLATION	454608	PLGSDVEyEAINLRG		activity, induced; molecular association, regulation		Lyn(INDUCES); Lck(INDUCES)		12482262; 7885	3	0	17		
Fer	EC 2.7.10.2; KINASE; Kinase, protein; Protein kinase, TK; Protein kinase, tyrosine (non-receptor)	P16591	2241	FER	5q21	human	Y615	PHOSPHORYLATION	6311907	EAKILKQyDHPNIVK	Pkinase_Tyr	enzymatic activity, induced				6277001	1	0	1		
EphA4	EC 2.7.1.112; EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Protein kinase, TK; Protein kinase, tyrosine (receptor)	Q03137	13838	Epha4		mouse	Y779	PHOSPHORYLATION	450858	EDDPEAAyTTRGGKI	Pkinase_Tyr	enzymatic activity, induced	cell cycle regulation; cell motility, altered			2790302; 1052900	2	21	724		
Notch 2	Membrane protein, integral; Motility/polarity/chemotaxis; Receptor, misc.	Q9QW30	29492	Notch2		rat	S2090	PHOSPHORYLATION	2154600	VLCGPNRsFLSLKHT		activity, induced	cell differentiation, altered; transcription, altered			2783	1	0	0		
MDM4	EC 6.3.2.-; Ligase; UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase	O15151	4194	MDM4	1q32	human	S367	PHOSPHORYLATION	457676	PDCRRTIsAPVVRPK		protein degradation; protein stabilization; molecular association, regulation; ubiquitination; intracellular localization	cell growth, altered	14-3-3 zeta(INDUCES); 14-3-3 epsilon(INDUCES); p53(DISRUPTS); USP7(DISRUPTS); MDM2(DISRUPTS); 14-3-3 beta(INDUCES); 14-3-3 theta(INDUCES); 14-3-3 gamma(INDUCES); MDM2(INDUCES)		2425229; 9981402; 7776; 7113; 8914; 8635; 7302; 25712607; 11387294	17	3	2	phosphorylation induces MDM4 degradation by MDM2, and inhibits the ability of MDM4 to repress transcriptional activity of p53.; lower level of MDM4 ubiquitination were observed on the triple mutant S342/367/403/A; MDM4342/A367A/403A mutant is resistant to MDM2 degradation after DNA damage, but is degradated after ARF expression.   	
SKAP55	Adaptor/scaffold; Motility/polarity/chemotaxis	Q86WV1	8631	SKAP1	17q21.32	human	Y298	PHOSPHORYLATION	460297	KGVDYASyYQGLWDC		molecular association, regulation	cell adhesion, altered	SLP76(DISRUPTS)		7701	1	0	0		
PDX1	DNA binding protein; Transcription factor	P52946	18609	Pdx1		mouse	S61	PHOSPHORYLATION	458401	LGSLEQGsPPDISPY		protein degradation				7451	3	0	0		
MAG	Cell adhesion; Membrane protein, integral	P07722	29409	Mag		rat	Y620	PHOSPHORYLATION	451280	LTEELAEyAEIRVK_		molecular association, regulation		PLCG1(INDUCES); Fyn(INDUCES)		3463	1	0	0	L-MAG but not S-MAG expressed in fibroblasts was capable of binding PLCgamma SH2 domains.	
TRF2	DNA binding protein; DNA repair	Q15554	7014	TERF2	16q22.1	human	T188	PHOSPHORYLATION	456963	HMSKDPTtQKLRNDL	TRF; PCI	intracellular localization				6951	2	0	0	TRF2 T188 localizes to telomeres iin crisis and associates with Double stranded breaks in photo-induced cells.  	
Rap1B	G protein; G protein, monomeric, Ras	P61224	5908	RAP1B	12q14	human	S179	PHOSPHORYLATION	451799	PGKARKKsSCQLL__		activity, induced; protein conformation				9980427	5	1	0		
MEK1	EC 2.7.12.2; KINASE; Kinase, protein; Protein kinase, STE; Protein kinase, dual-specificity	P29678	100009316	MAP2K1		rabbit	S218	PHOSPHORYLATION	448514	VSGQLIDsMANSFVG	Pkinase	enzymatic activity, induced				894	90	5	54	in vitro	
smMLCK	EC 2.7.11.18; KINASE; Kinase, protein; Protein kinase, CAMK; Protein kinase, Ser/Thr (non-receptor)	P29294	100009143	MYLK		rabbit	S1005	PHOSPHORYLATION	455821	GLSGRKSsTGSPTSP	DUF2656	activity, induced; intracellular localization				6323; 8842	7	8	8		
calnexin	Calcium-binding protein; Endoplasmic reticulum; Membrane protein, integral; Motility/polarity/chemotaxis	P24643		CANX		dog	S565	PHOSPHORYLATION	456360	EEDGGTAsQEEDDRK	Ycf1; Bravo_FIGEY; DUF1510; TRAP_alpha	molecular association, regulation; intracellular localization		PACS2(DISRUPTS)		2704325	5	44	44		
caveolin-2	Adaptor/scaffold; Motility/polarity/chemotaxis	P51636	858	CAV2	7q31.1	human	S36	PHOSPHORYLATION	469561	DPEKFADsDQDRDPH	Caveolin	activity, induced				8324	3	3	3	formation of caveolae	
Spinophilin	Adaptor/scaffold; Protein phosphatase, regulatory subunit	Q6R891	217124	Ppp1r9b		mouse	S15	PHOSPHORYLATION	455339	GPGGPLRsASPHRSA			cytoskeletal reorganization			4579	1	0	0		
SIIR	Transcription initiation complex	Q15170	9338	TCEAL1	Xq22.1	human	S37	PHOSPHORYLATION	451218	KSSPPRSsLRRSSPR	BEX; Myticin-prepro		transcription, altered			3453	1	0	0	S36A/S37A mutation resulted in a substantial loss of LTR repression function suggesting that RSV LTR repression may be regulated by S36 and/or S37 phosphorylation.	
IRS1	Adaptor/scaffold; Motility/polarity/chemotaxis	P35570	25467	Irs1		rat	S612	PHOSPHORYLATION	447562	DDGYMPMsPGVAPVP		molecular association, regulation		PIK3R1(DISRUPTS)		1903000	30	4	3		
N-WASP	Adaptor/scaffold; Motility/polarity/chemotaxis	Q95107		WASL		cow	Y256	PHOSPHORYLATION	450253	RETSKVIyDFIEKTG	PBD		cytoskeletal reorganization			10296913	7	36	1347	required for formation of Shigella-induced actin comet tails
	
NFkB-p100	DNA binding protein; Transcription factor	Q00653	4791	NFKB2	10q24	human	S711	PHOSPHORYLATION	25234803	PLPSPPTsDSDSDSE		protein degradation; ubiquitination		FBXW7(INDUCES)		27105701	2	0	0		
LRRK2	EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, Ser/Thr (non-receptor); Protein kinase, TKL	Q5S007	120892	LRRK2	12q12	human	S910	PHOSPHORYLATION	4725893	LVKKKSNsISVGEFY		molecular association, regulation; intracellular localization; phosphorylation		14-3-3 beta(INDUCES); 14-3-3 theta(INDUCES); 14-3-3 zeta(INDUCES); 14-3-3 epsilon(INDUCES); 14-3-3 eta(INDUCES)		15022721; 15022728; 21691001	9	8	0	stimulates phosphorylation of S973	
JNK3	EC 2.7.11.24; KINASE; Kinase, protein; Protein kinase, CMGC; Protein kinase, Ser/Thr (non-receptor)	P49187	25272	Mapk10		rat	T131	PHOSPHORYLATION	448033	ISLLNVFtPQKTLEE	Pkinase		apoptosis, induced			1143	1	0	0		
NFAT3	DNA binding protein; Transcription factor	Q14934	4776	NFATC4	14q11.2	human	S285	PHOSPHORYLATION	13419501	SSASPALsRRGSLGE			transcription, altered			12482414	1	1	0		
CTNND1	Actin binding protein; Adaptor/scaffold; Cell adhesion; G protein regulator, misc.; Motility/polarity/chemotaxis	P30999	12388	Ctnnd1		mouse	Y112	PHOSPHORYLATION	472275	PGQIVETyTEEDPEG		molecular association, regulation	cytoskeletal reorganization	CDH1(INDUCES); RhoA(DISRUPTS)		9157	2	0	0	 resposible for the dendritic phenotype in fibroblasts; decreases the amount of active RhoA	
occludin	Cell adhesion; Membrane protein, integral; Membrane protein, multi-pass; Motility/polarity/chemotaxis	Q16625	100506658	OCLN	5q13.1	human	Y474	PHOSPHORYLATION	3666920	YREESEEyMAAADEY	DUF342; APG6; TBPIP; DUF4151; Occludin_ELL; UPF0184; GrpE; DUF4200; Laminin_II; DUF4164; TMF_TATA_bd	molecular association, regulation	cell motility, altered	PIK3R1(INDUCES)		12558703	1	0	2		
ERF	DNA binding protein; Transcription factor	P50548	2077	ERF	19q13	human	T526	PHOSPHORYLATION	448321	GEAGGPLtPRRVSSD		intracellular localization	cell cycle regulation; transcription, induced			6956; 1078; 6957	4	12	123	phosphorylation of this site suppresses Ras-induced tumorigenicity	
CACNA1E	Channel, calcium; Membrane protein, integral; Membrane protein, multi-pass	Q07652	54234	Cacna1e		rat	S369	PHOSPHORYLATION	455593	RRATIKRsRTEAMTR		activity, induced				5534	1	0	0	potentiation of Ca(2+) currents	
AML1	DNA binding protein; Transcription factor	Q01196	861	RUNX1	21q22.3	human	S249	PHOSPHORYLATION	454399	DTRQIQPsPPWSYDQ		activity, induced; molecular association, regulation; phosphorylation	transcription, altered; cell growth, altered	CBFB(INDUCES)		8075512; 4042514	9	5	44		
KCNN4	Channel, potassium; Membrane protein, integral; Membrane protein, multi-pass	O15554	3783	KCNN4	19q13.2	human	T329	PHOSPHORYLATION	452144	AWMFYKHtRRKESHA	CaMBD	activity, inhibited				8374	2	0	0	inhibition during prolonged PMA treatment (not short-term)	
FOXO1A	DNA binding protein; Nuclear receptor co-regulator; Transcription factor	Q9R1E0	56458	Foxo1		mouse	S499	PHOSPHORYLATION	4911902	NVMMGPNsVMPAYGS			transcription, inhibited			4910502	1	0	0		
TSAd	Adaptor/scaffold	Q9NP31	9047	SH2D2A	1q21	human	Y290	PHOSPHORYLATION	449441	PDEPIAFyAMGRGSP		molecular association, regulation		Lck(INDUCES)		4042501	1	3	140		
Bcr/Abl	EC 2.7.10.2; KINASE; Kinase, protein; Protein kinase, TK; Protein kinase, tyrosine (non-receptor)	A9UF07		BCR/ABL		human	Y177	PHOSPHORYLATION	22639318	ADAEKPFyVNVEFHH		molecular association, regulation	cell growth, induced; transcription, induced	Grb2(INDUCES)		3916	1	2	645	transcription from ets/AP1  	
ACC1	Carbohydrate Metabolism - propanoate; Carbohydrate Metabolism - pyruvate; EC 6.3.4.14; EC 6.4.1.2; Ligase; Lipid Metabolism - fatty acid biosynthesis	P11497	60581	Acaca		rat	S1200	PHOSPHORYLATION	448290	IPTLNRMsFASNLNH	ACC_central	enzymatic activity, inhibited				2742	3	3	2		
ER-alpha	DNA binding protein; Nuclear receptor	P03372	2099	ESR1	6q25.1	human	S282	PHOSPHORYLATION	6048401	EGRGEVGsAGDMRAA		activity, inhibited	transcription, altered			12021304	4	0	0	inhibits ligand-independent activation of ER-alpha	
eNOS	Amino Acid Metabolism - arginine and proline; EC 1.14.13.39; Oxidoreductase	Q7YSG7	397557	NOS3		pig	T497	PHOSPHORYLATION	447885	TGIARKKtFKEVANA		enzymatic activity, inhibited				4465	56	1	1		
SRC-3	ACETYLTRANSFERASE; Acetyltransferase; EC 2.3.1.48; Motility/polarity/chemotaxis; Nuclear receptor co-regulator; Transcription, coactivator/corepressor	Q9Y6Q9	8202	NCOA3	20q12	human	S1033	PHOSPHORYLATION	4252802	NRPLLRNsLDDLVGP		protein stabilization; molecular association, regulation		PSMA3(DISRUPTS)		4248206	1	1	0	some subset of these 8 residues	
SNCAIP	Vesicle protein	Q9Y6H5	9627	SNCAIP	5q23.2	human	S211	PHOSPHORYLATION	2873902	MAPFCVLsPVKSPHL		molecular association, regulation		Pin1(INDUCES)		2865404	0	0	0		
STIM1	Calcium-binding protein; Endoplasmic reticulum; Membrane protein, integral	Q13586	6786	STIM1	11p15.5	human	S668	PHOSPHORYLATION	484156	IGEETDSsPGRKKFP		molecular association, regulation; intracellular localization; activity, inhibited	cytoskeletal reorganization	EB1(DISRUPTS)		25712651; 11419346	2	11	3	involved in suppression of store-operated calcium entry during mitosis; Phosphorylation dissociates STIM1 from EB1 during mtosis, and excludes ER from the mitotic spindle.	
APE1	DNA binding protein; DNA repair; Deoxyribonuclease; EC 3.1.-.-; EC 4.2.99.18; Endoplasmic reticulum; Hydrolase; Lyase; Transcription, coactivator/corepressor	P28352	11792	Apex1		mouse	T232	PHOSPHORYLATION	14645304	NKKNAGFtPQERQGF	Exo_endo_phos	enzymatic activity, inhibited	apoptosis, altered			14551406	2	0	0	in vitro and in MPP-treated neurons	
EphA4	EC 2.7.1.112; EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Protein kinase, TK; Protein kinase, tyrosine (receptor)	Q03137	13838	Epha4		mouse	Y928	PHOSPHORYLATION	450651	QAIKMDRyKDNFTAA	SAM_2	activity, inhibited	cell adhesion, altered			3090	1	0	0		
VEGFR2	EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Protein kinase, TK; Protein kinase, tyrosine (receptor)	P35918	16542	Kdr		mouse	Y1212	PHOSPHORYLATION	447902	VCDPKFHyDNTAGIS		molecular association, regulation; phosphorylation; enzymatic activity, induced		Src(INDUCES)		3660; 3661	12	4	58		
GAP43	Cell surface	P06836	281777	GAP43		cow	S41	PHOSPHORYLATION	448719	AATKIQAsFRGHITR	IQ	protein processing				9383; 8519	14	8	5	inhibits cleavage by m-calpain; blocks proteolytic cleavage by m-calpain	
NHE3	Membrane protein, integral; Membrane protein, multi-pass; Transporter	P26433	24784	Slc9a3		rat	S605	PHOSPHORYLATION	450900	SLEQRRRsIRDTEDM		molecular association, regulation; intracellular localization; activity, inhibited		SYT1(INDUCES)		11390404; 3184; 8680	9	1	0		
Crk	Adaptor/scaffold; Motility/polarity/chemotaxis	Q63768	54245	Crk		rat	Y221	PHOSPHORYLATION	447951	GGPEPGPyAQPSVNT		molecular association, regulation		EGFR(DISRUPTS)		815	19	9	1142		
KDELR1	Endoplasmic reticulum; Membrane protein, integral; Membrane protein, multi-pass	P24390	10945	KDELR1	19q13.3	human	S209	PHOSPHORYLATION	455669	VLKGKKLsLPA____		intracellular localization				5836	1	0	0		
dynactin 1	Microtubule binding protein; Motility/polarity/chemotaxis; Motor protein	Q14203	1639	DCTN1	2p13	human	S19	PHOSPHORYLATION	455515	TPSGSRMsAEASARP		intracellular localization	cytoskeletal reorganization			27902330	2	0	0	accumulation at spindle poles, required for central spindle assembly	
optineurin	Inhibitor protein	Q96CV9	10133	OPTN	10p13	human	S177	PHOSPHORYLATION	4762451	SSGSSEDsFVEIRMA		molecular association, regulation; intracellular localization	cell cycle regulation; autophagy, induced	SPTLC3(INDUCES); RAB8A(DISRUPTS)		23260326; 21588909	3	11	1		
PKCB	EC 2.7.11.13; KINASE; Kinase, protein; Motility/polarity/chemotaxis; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor)	P05771	5579	PRKCB	16p11.2	human	S661	PHOSPHORYLATION	448672	QNEFAGFsYTNPEFV	Pkinase_C	intracellular localization				1173027	14	21	140	Requires dual phosphorylation to locate to pericentrion.	
Rb	Nuclear receptor co-regulator; Transcription, coactivator/corepressor; Tumor suppressor	P13405	19645	Rb1		mouse	T367	PHOSPHORYLATION	447982	ANVVTPHtPVRTVMN	RB_A	molecular association, regulation		E2F1(DISRUPTS)		1258	7	20	35		
Myc	DNA binding protein; Transcription factor	P01108	17869	Myc		mouse	S329	PHOSPHORYLATION	2750300	AKRAKLDsGRVLKQI	Myc_N	protein stabilization	transcription, induced; cell growth, altered			2704335	1	0	0	enhances the oncogenic transforming activity of c-Myc	
PKAR2B	Mitochondrial; Protein kinase, regulatory subunit	P31323	5577	PRKAR2B	7q22	human	S114	PHOSPHORYLATION	452036	NRFTRRAsVCAEAYN		intracellular localization	transcription, altered			3962	2	34	163		
Smad2	DNA binding protein; Transcription factor	Q15796	4087	SMAD2	18q21.1	human	S260	PHOSPHORYLATION	450146	TLSPVNHsLDLQPVT		molecular association, regulation; intracellular localization		Smad3(INDUCES)		2766	1	0	0		
Kv7.1	Channel, potassium; Membrane protein, integral; Membrane protein, multi-pass	P51787	3784	KCNQ1	11p15.5	human	S464	PHOSPHORYLATION	456163	SVDGYDSsVRKSPTL	KCNQ_channel	activity, induced				6659	1	2	0		
NHE1	Membrane protein, integral; Membrane protein, multi-pass; Motility/polarity/chemotaxis; Transporter	P19634	6548	SLC9A1	1p36.1-p35	human	S796	PHOSPHORYLATION	460570	QRIQRCLsDPGPHPE		molecular association, regulation		CA2(NOT_REPORTED)		7703	3	10	34		
Met	EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Protein kinase, TK; Protein kinase, tyrosine (receptor)	P16056	17295	Met		mouse	Y1347	PHOSPHORYLATION	448472	STFIGEHyVHVNATY		molecular association, regulation	cell motility, altered; cytoskeletal reorganization	Shc1(INDUCES); PIK3C2A(INDUCES); Gab1(INDUCES); Grb2(INDUCES)		2849; 2850	21	5	89		
claspin	Actin binding protein; Cell cycle regulation	Q9HAW4	63967	CLSPN	1p34.2	human	S30	PHOSPHORYLATION	467250	EADSPSDsGQGSYET		protein degradation; molecular association, regulation	cell cycle regulation	BTRC(INDUCES)		8187	1	0	0	claspin degradation is necessary for termination of the DNA replication checkpoint.	
CDK5R1	Protein kinase, regulatory subunit	Q15078	8851	CDK5R1	17q11.2	human	S8	PHOSPHORYLATION	471392	MGTVLSLsPSYRKAT	CDK5_activator	protein stabilization; intracellular localization				25083305; 9104	5	0	0	S8 regulates the cytoplasmic distribution of CDK5R1. When S8 is unphosphorylated  it is localized to perinucleat region, and when is phosphorylated CDK5R1 is throughout the whole cytoplasm. ; inhibits calpain-dependent cleavage of Cdk5R1 (p35 to p25)	
PDK1	EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor)	O15530	5170	PDPK1	16p13.3	human	S241	PHOSPHORYLATION	447693	SKQARANsFVGTAQY	Pkinase; YukC	molecular association, regulation; enzymatic activity, induced		14-3-3 theta(INDUCES); 14-3-3 eta(INDUCES)		8257; 2680; 2361; 5608	43	48	211		
PDGFRB	EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Protein kinase, TK; Protein kinase, tyrosine (receptor)	P09619	5159	PDGFRB	5q33.1	human	Y1021	PHOSPHORYLATION	447523	PNEGDNDyIIPLPDP		activity, induced; molecular association, regulation; phosphorylation		PLCG1(INDUCES)		5876; 7451003; 1229; 1691; 2650	19	0	0	AKT and GSK3 phosphorylation; Y1009 and Y1021 phosphorylation mediates PDGFBB and thrombin induced calcium signaling. ; Specificity of binding of SH2 domains can be tailored by change of residues in the +1 to +5 positions, flanking the phosphotyrosine.  	
PLD2	EC 3.1.4.4; Lipid Metabolism - ether lipid; Lipid Metabolism - glycerophospholipid; Motility/polarity/chemotaxis; Phospholipase	O14939	5338	PLD2	17p13.1	human	Y415	PHOSPHORYLATION	10036101	ALGINSGySKRALML		enzymatic activity, induced				12778820; 9985922	3	1	0		
ER-alpha	DNA binding protein; Nuclear receptor	P03372	2099	ESR1	6q25.1	human	S102	PHOSPHORYLATION	449799	GGFPPLNsVSPSPLM	Oest_recep	activity, induced	transcription, induced			6685	3	1	0		
TRPV1	Channel, cation; Membrane protein, integral; Membrane protein, multi-pass; Receptor, misc.	O35433	83810	Trpv1		rat	S502	PHOSPHORYLATION	450016	YFLQRRPsLKSLFVD		activity, induced; receptor desensitization, altered		RNUXA(INDUCES)		8873; 25797202; 8872; 8874; 12482281; 8871; 2725501; 8750	14	0	0	regulate TRPV1 channel activity	
PLK4	EC 2.7.11.21; KINASE; Kinase, protein; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor)	Q64702	20873	Plk4		mouse	S303	PHOSPHORYLATION	12654008	ASSGTSLsGSLLDRR		protein degradation; ubiquitination				12525201	1	1	0		
DAB1	Adaptor/scaffold	P97318	13131	Dab1		mouse	Y220	PHOSPHORYLATION	447630	PETEENIyQVPTSQK		molecular association, regulation; intracellular localization	cell motility, altered; cytoskeletal reorganization; cell adhesion, altered; cell growth, altered	Nck2(INDUCES); Crk(INDUCES); CrkL(INDUCES)		6498; 3806; 10425111; 3654; 3631	11	2	0		
TNNI3	Actin binding protein; Motility/polarity/chemotaxis; Motor protein	P48787	21954	Tnni3		mouse	S45	PHOSPHORYLATION	450691	KKSKISAsRKLQLKT		activity, induced; protein conformation; activity, inhibited	cell motility, altered; cytoskeletal reorganization			13320406; 1968302; 3084; 7889902; 4862627; 4862629; 8954; 4862628	18	1	0		
Met	EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Protein kinase, TK; Protein kinase, tyrosine (receptor)	P08581	4233	MET	7q31	human	Y1356	PHOSPHORYLATION	448473	YVHVNATyVNVKCVA		molecular association, regulation; enzymatic activity, inhibited; activity, inhibited	cell motility, altered; cell growth, altered	PIK3C2A(INDUCES); Src(INDUCES); PLCG1(INDUCES); Gab1(INDUCES); SOS1(INDUCES); Shc1(INDUCES); Met(INDUCES); FAK(INDUCES); Grb2(INDUCES); PIK3R1(INDUCES)		2466202; 2838; 713; 2852648; 2845; 2844; 10351400; 2841; 5482; 2839; 2842; 2852628; 2846; 2847	20	4	89		
NDEL1	Microtubule binding protein; Protease	Q9GZM8	81565	NDEL1	17p13.1	human	S231	PHOSPHORYLATION	474507	GTENTFPsPKAIPNG	NUDE_C	molecular association, regulation; intracellular localization		PAFAH1B1(INDUCES)		9081	4	9	0		
4E-BP1	Translation; Translation initiation	Q60876	13685	Eif4ebp1		mouse	T36	PHOSPHORYLATION	447497	PPGDYSTtPGGTLFS	eIF_4EBP	molecular association, regulation		eIF4E(DISRUPTS); eIF4E(INDUCES)		2855904; 5769	89	24	87		
ARRB1	Adaptor/scaffold	P29066	25387	Arrb1		rat	S412	PHOSPHORYLATION	447493	EEDDGTGsPHLNNR_		intracellular localization				455	7	18	1	Cytoplasmic beta-arrestin 1 is constitutively phosphorylated. It is recruited to the plasma membrane by agonist binding to receptor where is rapidly dephosphorylated. Dephosphorylation is required for clathrin binding and receptor endocytosis.	
PDE4A	EC 3.1.4.17; Nucleotide Metabolism - purine; Phosphodiesterase	P27815	5141	PDE4A	19p13.2	human	S145	PHOSPHORYLATION	458389	ATSQRREsFLYRSDS		enzymatic activity, induced				7471	4	7	0		
Dok1	Adaptor/scaffold; Motility/polarity/chemotaxis	Q99704	1796	DOK1	2p13	human	Y398	PHOSPHORYLATION	448369	ARVKEEGyELPYNPA		molecular association, regulation; phosphorylation		RASA1(INDUCES); Nck1(INDUCES)		1354	4	10	568		
FASN	ACETYLTRANSFERASE; Acetyltransferase; EC 1.1.1.100; EC 1.3.1.10; EC 2.3.1.38; EC 2.3.1.39; EC 2.3.1.41; EC 2.3.1.85; EC 3.1.2.14; EC 4.2.1.61; Hydrolase; Lipid Metabolism - fatty acid biosynthesis; Lyase; Oxidoreductase	P49327	2194	FASN	17q25	human	S1028	PHOSPHORYLATION	27930800	LWKDNWVsFMDTMLQ			transcription, inhibited			27902335	1	1	0		
OGG1	DNA repair; Deoxyribonuclease; EC 3.2.2.-; EC 4.2.99.18; Lyase	O15527	4968	OGG1	3p26.2	human	S231	PHOSPHORYLATION	10036106	WLQQLREsSYEEAHK	HhH-GPD	enzymatic activity, inhibited				9985908	1	0	0		
calpain 2	EC 3.4.22.53; Motility/polarity/chemotaxis; Protease	P17655	824	CAPN2	1q41-q42	human	S50	PHOSPHORYLATION	451162	GTLFQDPsFPAIPSA	Peptidase_C2		cell motility, altered; cell adhesion, altered			3356	2	0	0		
Rad9	Apoptosis; Cell cycle regulation; DNA replication; Deoxyribonuclease; EC 3.1.11.2	Q99638	5883	RAD9A	11q13.1-q13.2	human	S336	PHOSPHORYLATION	449816	PGPQPPKsPGPHSEE			cell cycle regulation			13354725; 8762	3	2	10		
PFKFB2	Carbohydrate Metabolism - fructose and mannose; EC 2.7.1.105; EC 3.1.3.46; Kinase, other; Motility/polarity/chemotaxis; Phosphatase (non-protein)	P26285	287019	PFKFB2		cow	S484	PHOSPHORYLATION	452046	IRRPRNYsVGSRPLQ		enzymatic activity, induced				3947	6	11	98		
Oct4	DNA binding protein; Transcription factor	Q01860	5460	POU5F1	6p21.31	human	T235	PHOSPHORYLATION	15502889	QARKRKRtSIENRVR	Homeobox	molecular association, regulation	transcription, inhibited		DNA(DISRUPTS)	25227623	1	1	1		
ZAP70	EC 2.7.10.2; KINASE; Kinase, protein; Protein kinase, TK; Protein kinase, tyrosine (non-receptor)	P43403	7535	ZAP70	2q12	human	Y493	PHOSPHORYLATION	447505	LGADDSYyTARSAGK	Pkinase_Tyr	phosphorylation; enzymatic activity, induced	cell adhesion, altered; transcription, altered			808; 6436; 3767; 809; 810; 8899	15	11	440	increases PI3K activation and adhesion	
FLRT1	Cell adhesion; Membrane protein, integral; Motility/polarity/chemotaxis	Q9NZU1	23769	FLRT1	11q12-q13	human	Y572	PHOSPHORYLATION	14150102	GSRKKDDyMESGTKK		intracellular localization	cell growth, altered			14058618	1	0	0	regulates ERK1/2 activation	
PXN	Adaptor/scaffold; Cell adhesion; Cytoskeletal protein; Motility/polarity/chemotaxis	P49023	5829	PXN	12q24.31	human	S178	PHOSPHORYLATION	448603	PPLPGALsPLYGVPE	Paxillin		cell motility, altered; cytoskeletal reorganization; cell adhesion, altered			2358	7	0	0		
CDH5	Cell adhesion; Membrane protein, integral; Motility/polarity/chemotaxis	P33151	1003	CDH5	16q22.1	human	Y731	PHOSPHORYLATION	456049	PYDTLHIyGYEGSES	Cadherin_C	molecular association, regulation		CTNNB1(DISRUPTS)		6644	3	0	1		
Bcl-3	Apoptosis; Nuclear receptor co-regulator; Transcription regulation	P20749	602	BCL3	19q13.1-q13.2	human	S402	PHOSPHORYLATION	3627521	LSASPSSsPSQSPPR		protein degradation; molecular association, regulation; ubiquitination	transcription, altered; cell growth, altered	HDAC6(INDUCES); HDAC3(INDUCES); HDAC1(INDUCES)		4319	1	0	0		
CCND1	Activator protein; Nuclear receptor co-regulator	P25322	12443	Ccnd1		mouse	T288	PHOSPHORYLATION	451435	AGLACTPtDVRDVDI		protein degradation	cell cycle regulation			3640; 9938528	5	0	0		
VRK1	EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, CK1; Protein kinase, Ser/Thr (non-receptor)	Q80X41	22367	Vrk1		mouse	S355	PHOSPHORYLATION	483969	SVKTRPAsKKRKKEA		enzymatic activity, inhibited	cell cycle regulation; apoptosis, altered			18410843	3	0	0		
WNK1	EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor)	Q9JIH7	116477	Wnk1		rat	S382	PHOSPHORYLATION	454105	KRASFAKsVIGTPEF	Pkinase	enzymatic activity, induced				4211	6	4	0		
PPP1R2	Inhibitor protein; Motility/polarity/chemotaxis; Protein phosphatase, regulatory subunit	P41236	5504	PPP1R2	3q29	human	S121	PHOSPHORYLATION	449052	YRIQEQEsSGEEDSD	IPP-2	intracellular localization				3958	3	38	29	Phosphorylation is required for nuclear localization during S phase.	
IRF4	DNA binding protein; Transcription factor	Q64287	16364	Irf4		mouse	S446	PHOSPHORYLATION	26335000	YHRSLRHsSIQE___			cell differentiation, induced; transcription, induced		DNA(INDUCES)	25779413	2	1	0	production of IL-17 and IL-21 	
Dok1	Adaptor/scaffold; Motility/polarity/chemotaxis	Q99704	1796	DOK1	2p13	human	Y296	PHOSPHORYLATION	448366	LDSPPALyAEPLDSL		molecular association, regulation; intracellular localization		RASA1(INDUCES); CD45(INDUCES)		7910503; 1352	3	10	163		
EphA4	EC 2.7.1.112; EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Protein kinase, TK; Protein kinase, tyrosine (receptor)	Q03137	13838	Epha4		mouse	Y596	PHOSPHORYLATION	450856	LNQGVRTyVDPFTYE	CD34_antigen	enzymatic activity, induced	cell motility, altered; cytoskeletal reorganization			6739; 1052900	5	11	83	YY->EE mutation induced receptor clustering that induced growth cone collapse and axonal guidance problems.; in vitro	
PSARL	Apoptosis; EC 3.4.21.105; Membrane protein, integral; Membrane protein, multi-pass; Mitochondrial; Protease	Q9H300	55486	PARL	3q27.1	human	S65	PHOSPHORYLATION	471330	RKVEPRRsDPGTSGE		protein processing				9119	1	1	0	involved in mitochondrial fragmentation	
RIPK2	EC 2.7.10.2; EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, Ser/Thr (non-receptor); Protein kinase, TKL	O43353	8767	RIPK2	8q21	human	S176	PHOSPHORYLATION	460844	KWRMMSLsQSRSSKS	Pkinase	enzymatic activity, induced				2852670	1	9	23		
IL7R	Membrane protein, integral; Receptor, cytokine	P16871	3575	IL7R	5p13	human	Y449	PHOSPHORYLATION	451291	GSNQEEAyVTMSSFY		molecular association, regulation		PIK3R1(INDUCES)		3510	3	0	0		
IRS1	Adaptor/scaffold; Motility/polarity/chemotaxis	P35568	3667	IRS1	2q36	human	S1101	PHOSPHORYLATION	453434	GCRRRHSsETFSSTP		activity, inhibited				4146	7	19	98		
IRS1	Adaptor/scaffold; Motility/polarity/chemotaxis	P35570	25467	Irs1		rat	S318	PHOSPHORYLATION	451399	MVGGKPGsFRVRASS		molecular association, regulation; phosphorylation		InsR(DISRUPTS)		3599	11	8	0	Inhibits tyrosine phosphorylation	
CAMK2A	EC 2.7.11.17; KINASE; Kinase, protein; Protein kinase, CAMK; Protein kinase, Ser/Thr (non-receptor)	P11275	25400	Camk2a		rat	T305	PHOSPHORYLATION	448802	KLKGAILtTMLATRN		molecular association, regulation; enzymatic activity, inhibited	cytoskeletal reorganization	calmodulin(DISRUPTS)		3796; 15331009; 2852600	18	3	0	regulate synaptic strength 	
G6b	Immunoglobulin superfamily; Membrane protein, integral; Receptor, misc.	O95866	80739	G6B	6p21.33	human	Y237	PHOSPHORYLATION	454848	PADASTIyAVVV___		molecular association, regulation		SH2D1B(NOT_REPORTED); CSK(INDUCES); Syk(INDUCES); Src(INDUCES); SHP-2(INDUCES); SHP-1(INDUCES); Fyn(INDUCES); PLCG2(INDUCES); Arg(NOT_REPORTED); PIK3CA(INDUCES)		27257055; 27932900	1	2	1		
hnRNP D0	RNA binding protein; RNA splicing	Q14103	3184	HNRNPD	4q21	human	S83	PHOSPHORYLATION	449336	DEGHSNSsPRHSEAA			transcription, inhibited; RNA stability, altered		RNA(INDUCES)	3001; 8555	3	41	16		
STYK1	EC 2.7.10.2; KINASE; Kinase, protein; Membrane protein, integral; Protein kinase, TK; Protein kinase, tyrosine (receptor)	Q6J9G1	243659	Styk1		mouse	Y334	PHOSPHORYLATION	458344	VTLGAPPyPEVPPTS	Pkinase_Tyr		apoptosis, inhibited; cell growth, altered			7403	1	0	0	mutation of this site promotes cellular apoptosis	
MST1	Autophagy; EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, STE; Protein kinase, Ser/Thr (non-receptor)	Q9JI11	58231	Stk4		mouse	S327	PHOSPHORYLATION	447924	SEEDEMDsGTMVRAA		enzymatic activity, induced	cell adhesion, altered			2608	2	1	1		
ARAF	EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, Ser/Thr (non-receptor); Protein kinase, TKL	P10398	369	ARAF	Xp11.4-p11.2	human	S432	PHOSPHORYLATION	3306310	IIHRDLKsNNIFLHE	Pkinase_Tyr	enzymatic activity, induced				3301229	1	1	0		
CDH1	Cell adhesion; Membrane protein, integral; Motility/polarity/chemotaxis; UBIQUITIN LIGASE; Ubiquitin ligase	P12830	999	CDH1	16q22.1	human	S844	PHOSPHORYLATION	478354	GSGSEAAsLSSLNSS	Cadherin_C	molecular association, regulation; intracellular localization	cell adhesion, altered	CTNNB1(DISRUPTS)		9612	3	0	0		
PAH	Amino Acid Metabolism - phenylalanine, tyrosine and tryptophan biosynthesis; EC 1.14.16.1; Oxidoreductase	P00439	5053	PAH	12q22-q24.2	human	S16	PHOSPHORYLATION	449074	PGLGRKLsDFGQETS		molecular association, regulation; protein conformation; enzymatic activity, induced		PAH(DISRUPTS)		8716; 17482921; 2111	6	4	36	PAH G46S mutant; The conformational change is around the phosphoserine and the catalytic domain (not global).	
BCKDHB	Amino Acid Metabolism - valine, leucine and isoleucine degradation; EC 1.2.4.4; Mitochondrial; Oxidoreductase	P21953	594	BCKDHB	6q14.1	human	S318	PHOSPHORYLATION	3336900	DVDTICKsVIKTGRL	Transketolase_C	enzymatic activity, inhibited		E1B-AP5(DISRUPTS)		4353	1	0	0		
PCNA	Cell cycle regulation	P12004	5111	PCNA	20pter-p12	human	Y211	PHOSPHORYLATION	471414	QLTFALRyLNFFTKA	PCNA_C	protein degradation; phosphorylation	cell growth, altered			9124	2	2	0	PCNA mutant Y211F, is degraded by proteosome-dependent degredation. Y211F mutation maintains protein function, cellular effects are due to degredation. ; Phosphorylation of T211 is associated with cellular proliferation such as liver regeneration. 	
ARHGAP24	GTPase activating protein, Rac/Rho; Motility/polarity/chemotaxis	Q8N264	83478	ARHGAP24	4q22.1	human	S415	PHOSPHORYLATION	4757012	HKLDVSRsPPLMVKK		activity, induced	cytoskeletal reorganization			12482285	1	5	1	membrane blebbing	
FOXM1 iso2	DNA binding protein; Transcription factor	Q08050-2	2305	FOXM1	12p13	human	S361	PHOSPHORYLATION	471396	PLLPRVSsYLVPIQF		protein stabilization	transcription, induced			9085	1	0	0	plays a role in the DNA damage/checkpoint signaling	
NFAT1	DNA binding protein; Transcription factor	Q60591	18019	Nfatc2		mouse	S223	PHOSPHORYLATION	447847	PRTSPIMsPRTSLAE			transcription, inhibited			1188	2	8	5		
COP1	EC 6.3.2.-; EC 6.3.2.19; Ligase; UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase	Q8NHY2	64326	RFWD2	1q25.1-q25.2	human	S387	PHOSPHORYLATION	467307	SDDSRTAsQLDEFQE		protein degradation; molecular association, regulation; intracellular localization		p53(DISRUPTS)		8251	2	0	0	phosphorylation of this site promotes COP1 autoubiquitination which prevents its interaction and stabilizes p53 	
Fascin	Actin binding protein; Cytoskeletal protein; Motility/polarity/chemotaxis	Q16658	6624	FSCN1	7p22	human	S39	PHOSPHORYLATION	450888	KVNASASsLKKKQIW	Fascin	molecular association, regulation	cytoskeletal reorganization	ACTA1(INDUCES)		9071; 12778809	8	5	0		
ARAF	EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, Ser/Thr (non-receptor); Protein kinase, TKL	P10398	369	ARAF	Xp11.4-p11.2	human	S264	PHOSPHORYLATION	3306300	SPSPASVsSGRKSPH		enzymatic activity, induced				3301229	1	1	0		
Cdc25A	EC 3.1.3.48; Motility/polarity/chemotaxis; PHOSPHATASE; Protein phosphatase, dual-specificity	P30304	993	CDC25A	3p21	human	S124	PHOSPHORYLATION	449127	PALKRSHsDSLDHDI	M-inducer_phosp	protein degradation				1619; 2163	6	1	0		
NTCP	Membrane protein, integral; Membrane protein, multi-pass; Transporter	P26435	24777	Slc10a1		rat	S226	PHOSPHORYLATION	456205	TPHLLATsSLMPFSG		intracellular localization				6602	2	0	0		
PLXNB1	Membrane protein, integral; Motility/polarity/chemotaxis; Receptor, misc.	O43157	5364	PLXNB1	3p21.31	human	Y1732	PHOSPHORYLATION	11485312	SVTGKAKyTLNDNRL	Plexin_cytopl	molecular association, regulation	cell motility, altered	PLCG2(INDUCES); PLCG1(INDUCES); Grb2(INDUCES)		11419367	1	0	0		
Fes	EC 2.7.10.2; KINASE; Kinase, protein; Protein kinase, TK; Protein kinase, tyrosine (non-receptor)	P07332	2242	FES	15q26.1	human	Y713	PHOSPHORYLATION	448353	REEADGVyAASGGLR	Pkinase_Tyr	molecular association, regulation; enzymatic activity, induced	cell differentiation, altered; cell growth, altered	Fes(INDUCES); Src(NOT_REPORTED)		6011117; 1329; 1172868; 1330; 1331	6	5	114	Y713F mutant was associated with a reduction in levels of Bcr.; mutation of this site reduces autophosphorylation of Y811 ; SH2 and catalytic domains of Fes and Abl interact with ligand, stimulating kinase activity. ; phosphorylation and Fes activation inhibited by ezrin Y478F mutation	
PLM	Cell surface; Channel, misc.; Membrane protein, integral	Q9Z239	56188	Fxyd1		mouse	S89	PHOSPHORYLATION	455220	SSIRRLSsRRR____	IncA	intracellular localization				2610203	7	2	49	After stimulation with phorbol ester.	
p73 iso2	DNA binding protein; Transcription factor	O15350-2	7161	TP73	1p36.3	human	S289	PHOSPHORYLATION	455781	GQVLGRRsFEGRICA	P53	activity, induced	apoptosis, induced; transcription, altered			5989	1	0	0		
PLD2	EC 3.1.4.4; Lipid Metabolism - ether lipid; Lipid Metabolism - glycerophospholipid; Motility/polarity/chemotaxis; Phospholipase	O14939	5338	PLD2	17p13.1	human	Y296	PHOSPHORYLATION	10036102	LILKCSSyRQARWWA	PH	enzymatic activity, inhibited; enzymatic activity, induced	carcinogenesis, inhibited; cell motility, altered			12778820; 15022725; 9985922	3	1	0		
BubR1	EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor)	O60566	701	BUB1B	15q15	human	S1043	PHOSPHORYLATION	483373	WKVGKLTsPGALLFQ			cell cycle regulation			5358603	3	7	2	pS1043 Ab delayed anaphase onset in vivo and in vitro	
eEF2K	EC 2.7.11.20; KINASE; Kinase, protein; Protein kinase, ATYPICAL; Protein kinase, Ser/Thr (non-receptor); Translation	O00418	29904	EEF2K	16p12.2	human	S441	PHOSPHORYLATION	23101751	ESENSGDsGYPSEKR		protein degradation; molecular association, regulation; ubiquitination		BRD8(INDUCES)		25573527	1	1	1		
CUTL1	DNA binding protein; Membrane protein, integral; Transcription factor	P53564	13047	Cux1		mouse	S1232	PHOSPHORYLATION	456479	IDYSQGAsPQPQHQL		molecular association, regulation			DNA(DISRUPTS)	6698	2	1	4		
TIF1A	Transcription initiation complex	Q9NYV6	54700	RRN3	16p12	human	S199	PHOSPHORYLATION	470003	IIARYVPsTPWFLMP	RRN3	molecular association, regulation; activity, inhibited	transcription, altered	eIF3S6IP(DISRUPTS); TAF4(DISRUPTS)		8849	2	0	0		
Jun	Transcription factor	P05412	3725	JUN	1p32-p31	human	Y170	PHOSPHORYLATION	447687	LHSEPPVyANLSNFN	Jun	molecular association, regulation		Abl iso2(INDUCES)		1029	1	0	0		
FRS2	Adaptor/scaffold	Q8C180	327826	Frs2		mouse	Y349	PHOSPHORYLATION	449784	RRPALLNyENLPSLP		molecular association, regulation		Grb2(INDUCES)		1356	2	9	73		
BDP1	EC 3.1.3.48; Motility/polarity/chemotaxis; Protein phosphatase, tyrosine (non-receptor)	Q99952	26469	PTPN18	2q21.1	human	Y281	PHOSPHORYLATION	450259	AVQTEEQyRFLYHTV	Y_phosphatase	molecular association, regulation		TEC(INDUCES)		2955	1	0	0		
MC4R	GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR	P32245	4160	MC4R	18q22	human	S329	PHOSPHORYLATION	449102	LGGLCDLsSRY____		receptor internalization, altered				2136	2	0	0		
PTPRA	EC 3.1.3.48; Membrane protein, integral; Motility/polarity/chemotaxis; PHOSPHATASE; Receptor protein phosphatase, tyrosine	P18052	19262	Ptpra		mouse	S204	PHOSPHORYLATION	447612	PLLARSPsTNRKYPP		molecular association, regulation; enzymatic activity, induced	cytoskeletal reorganization	Src(DISRUPTS)		14058610; 4651315	6	2	0	neurite outgrowth	
Akt1	EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor)	Q01314	280991	AKT1		cow	T308	PHOSPHORYLATION	447856	KDGATMKtFCGTPEY	Pkinase	intracellular localization; enzymatic activity, induced				4646617	462	2	12	Translocation to the plasma membrane leads to phosphorylation. 	
TSC2	Cell cycle regulation; GTPase activating protein, misc.; Nuclear receptor co-regulator; Tumor suppressor	P49816	24855	Tsc2		rat	S1381	PHOSPHORYLATION	450215	VDLSFQPsQPLSKSS		activity, inhibited; phosphorylation	translation, altered; apoptosis, inhibited			8973	2	0	1	inhibits mTOR signaling.  required for Wnt-3a to stimulation phosphorylation of S6K and 4EBP1 and increase protein levels of cyclin D1 and VEGF (cyclin D1 through translation not transcription).	
MCU	Membrane protein, integral; Membrane protein, multi-pass; Mitochondrial	Q3UMR5	215999	Mcu		mouse	S91	PHOSPHORYLATION	27259017	VISVRLPsRRERCQF			apoptosis, induced			27257011	1	0	0	increase CCDC109A current and myocardial cell death	
hnRNP K	RNA binding protein; RNA splicing; Spliceosome	P61978	3190	HNRNPK	9q21.32-q21.33	human	Y380	PHOSPHORYLATION	456004	YAGGRGSyGDLGGPI			translation, altered			6566	2	17	20	based on Y72/225/230/234/236/380A mutant	
PTPRB	EC 3.1.3.48; Membrane protein, integral; Motility/polarity/chemotaxis; PHOSPHATASE; Receptor protein phosphatase, tyrosine	B2RU80	19263	Ptprb		mouse	Y1982	PHOSPHORYLATION	454267	ENPLFPIyENVNPEY		molecular association, regulation	cytoskeletal reorganization	Fyn(INDUCES); Grb2(INDUCES)		14081207	1	1	35		
Akt1	EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor)	P31750	11651	Akt1		mouse	Y176	PHOSPHORYLATION	14515900	EKATGRYyAMKILKK	Pkinase	intracellular localization; enzymatic activity, induced	cell cycle regulation; transcription, altered			14146306	1	1	0	membrane localization	
emerin	Cytoskeletal protein; Membrane protein, integral	P50402	2010	EMD	Xq28	human	Y34	PHOSPHORYLATION	10897602	VGSTRRLyEKKIFEY	LEM	molecular association, regulation		BAF(INDUCES)		10425105	1	1	0		
OGG1	DNA repair; Deoxyribonuclease; EC 3.2.2.-; EC 4.2.99.18; Lyase	O15527	4968	OGG1	3p26.2	human	S232	PHOSPHORYLATION	10036104	LQQLRESsYEEAHKA	HhH-GPD	enzymatic activity, inhibited				9985908	1	0	0		
Cbl	Adaptor/scaffold; EC 6.3.2.-; EC 6.3.2.19; Ligase; Motility/polarity/chemotaxis; UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase	P22681	867	CBL	11q23.3	human	Y674	PHOSPHORYLATION	448874	SSSANAIySLAARPL			cell motility, altered			6767	2	22	695	Cbl mutant Y674/700/731/735/774F was used in this experiment	
Rb	Nuclear receptor co-regulator; Transcription, coactivator/corepressor; Tumor suppressor	P13405	19645	Rb1		mouse	S224	PHOSPHORYLATION	450020	VDYFIKFsPPALLRE		molecular association, regulation		E2F1(DISRUPTS)		1258	2	0	0		
Src	EC 2.7.10.2; KINASE; Kinase, protein; Protein kinase, TK; Protein kinase, tyrosine (non-receptor)	Q9WUD9	83805	Src		rat	S17	PHOSPHORYLATION	448231	DASQRRRsLEPAENV		enzymatic activity, induced	cell growth, altered			4724	9	21	11		
NRF2	DNA binding protein; Transcription factor	Q60795	18024	Nfe2l2		mouse	S355	PHOSPHORYLATION	18258504	PEHSVESsIYGDPPP		protein degradation; molecular association, regulation		BTRC(INDUCES)		18021029	1	0	0		
ephexin-1	Guanine nucleotide exchange factor, Rac/Rho	Q5I1Y9	424744	NGEF		chicken	Y17	PHOSPHORYLATION	455579	IEHIGLLyQEYRDKS		activity, induced	cell motility, altered; cytoskeletal reorganization			5518	4	0	2		
Lyn	EC 2.7.10.2; KINASE; Kinase, protein; Protein kinase, TK; Protein kinase, tyrosine (non-receptor)	P07948	4067	LYN	8q13	human	Y397	PHOSPHORYLATION	448695	RVIEDNEyTAREGAK	Pkinase_Tyr	enzymatic activity, induced	cell growth, altered			15331028; 4914024	15	33	2047		
LRP2	Membrane protein, integral; Motility/polarity/chemotaxis; Receptor, misc.	P98164	4036	LRP2	2q31.1	human	S4527	PHOSPHORYLATION	767902	IFENPMYsARDSAVK		receptor internalization, altered; receptor recycling, altered				762703	1	0	0		
RCAN1	Inhibitor protein	P53805	1827	RCAN1	21q22.12	human	T247	PHOSPHORYLATION	21511701	QTRRPEYtPIHLS__		protein stabilization	transcription, inhibited	PPP3CA(DISRUPTS)		21385516	2	0	0	T247 phosphorylation inhibits calcineurin phosphatase activity, and NFAT dependent transcription	
MYH10	Motility/polarity/chemotaxis; Motor protein	P35580	4628	MYH10	17p13	human	S1937	PHOSPHORYLATION	2017900	RGGPISFsSSRSGRR		activity, inhibited				2014204	1	7	2	S1937D shows slower kinetics of filament assembly in vitro.	
CD84	Cell surface; Immunoglobulin superfamily; Membrane protein, integral; Motility/polarity/chemotaxis	Q9UIB8	8832	CD84	1q24	human	Y296	PHOSPHORYLATION	454840	QPAESRIyDEILQSK		molecular association, regulation		SH2D1B(NOT_REPORTED); Arg(NOT_REPORTED)		27932900	0	7	184		
Ets-1	DNA binding protein; Motility/polarity/chemotaxis; Transcription factor	P13474	396235	ETS1		chicken	S251	PHOSPHORYLATION	449316	GKLGGQDsFESIESY		activity, inhibited				3214	2	6	0	The in vitro interaction of  Ets-1 with a high-affinity Ets binding site was assayed with EMSA.	
RPS3	Apoptosis; Ribosomal protein; Translation	P23396	6188	RPS3	11q13.3-q13.5	human	R65	DI-METHYLATION	9184302	VLGEKGRrIRELTAV	KH_2	intracellular localization				8164811	1	0	0	regulates ribosome assembly	
separase	EC 3.4.22.49; Protease	Q14674	9700	ESPL1	12q	human	S1126	PHOSPHORYLATION	447673	IAPSTNSsPVLKTKP		molecular association, regulation; enzymatic activity, inhibited; protein conformation	cell cycle regulation	CCNB1(INDUCES)		2865421; 1603; 1172817	8	6	0		
FEN1	DNA binding protein; DNA repair; Deoxyribonuclease; EC 3.1.-.-; Ribonuclease	P39748	2237	FEN1	11q12	human	S187	PHOSPHORYLATION	2708400	MDCLTFGsPVLMRHL	XPG_I	sumoylation; protein degradation; molecular association, regulation; intracellular localization; enzymatic activity, inhibited	cell cycle regulation	PCNA(DISRUPTS)		15278806; 8504; 25712619; 2704336	4	2	0		
PLD2	EC 3.1.4.4; Lipid Metabolism - ether lipid; Lipid Metabolism - glycerophospholipid; Motility/polarity/chemotaxis; Phospholipase	P97813	18806	Pld2		mouse	Y14	PHOSPHORYLATION	453410	NLFPYGDyLNSSQLH		intracellular localization				4130	1	0	0	Y14 F and YallF showed altered location in cytoplasm rather than at the plasmamembrane. 	
PXN	Adaptor/scaffold; Cell adhesion; Cytoskeletal protein; Motility/polarity/chemotaxis	Q8VI36	19303	Pxn		mouse	S130	PHOSPHORYLATION	450228	KQKSAEPsPTVMSSS	Paxillin		cell motility, altered; cytoskeletal reorganization			7852	5	14	4	regulates cells spreading	
OLIG2	Transcription factor	Q9EQW6	50913	Olig2		mouse	S14	PHOSPHORYLATION	18357901	LVSSRPSsPEPDDLF			cell cycle regulation; cell differentiation, altered; carcinogenesis, altered			18357300	1	1	0	maintains proliferation and suppresses differentiation of neural progenitors	
AQP9	Channel, misc.; Membrane protein, integral; Membrane protein, multi-pass	O43315	366	AQP9	15q	human	S11	PHOSPHORYLATION	477183	EGAEKGKsFKQRLVL			cytoskeletal reorganization			9392	2	0	0	mutation decreases sensitivity to hypo-osmolar conditions and formation of filopodia	
MOR-1	GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR	P35372	4988	OPRM1	6q24-q25	human	S365	PHOSPHORYLATION	447783	SNIEQQNsTRIRQNT		receptor internalization, altered				2831776	9	6	0		
NRF2	DNA binding protein; Transcription factor	Q60795	18024	Nfe2l2		mouse	S338	PHOSPHORYLATION	18258501	NDSDSGIsLNTSPSR		protein degradation; molecular association, regulation		BTRC(INDUCES)		18021029	3	0	0		
dematin	Actin binding protein; Motility/polarity/chemotaxis	Q08495	2039	EPB49	8p21.1	human	S403	PHOSPHORYLATION	450255	NELKKKAsLF_____	VHP	protein conformation				7660	4	0	0	controls the actin bundling activity of dematin	
SORL1	Cell surface; Membrane protein, integral; Receptor, misc.	Q92673	6653	SORL1	11q23.2-q24.2	human	S2206	PHOSPHORYLATION	11546400	APMITGFsDDVPMVI		molecular association, regulation; protein processing		GGA1(INDUCES)		11484411; 17675029	1	1	0	necessary for SORL1 ectodomain shedding	
MRLC2	Contractile protein	O14950	103910	MYL12B	18p11.31	human	S20	PHOSPHORYLATION	448595	KRPQRATsNVFAMFD	2-Hacid_dh_C; EF_hand_5	intracellular localization	cell motility, altered; cytoskeletal reorganization			7007; 5600; 5280; 6842209; 6275	50	28	282		
UBXN2B	Adaptor/scaffold; Endoplasmic reticulum	Q14CS0	137886	UBXN2B	8q12.1	human	T59	PHOSPHORYLATION	3217944	TVFKSPRtPPQRFYS		molecular association, regulation; intracellular localization				15571609	1	5	6	 important for Golgi disassembly at mitosis; inhibits p37 binding to Golgi membranes	
PSD-95	Adaptor/scaffold	P31016	29495	Dlg4		rat	Y533	PHOSPHORYLATION	473111	VTQMEVHyARPIIIL	Guanylate_kin	molecular association, regulation; intracellular localization				13359100	1	0	2	regulates synaptic clustering	
ARHGEF2	Guanine nucleotide exchange factor, Rac/Rho; Motility/polarity/chemotaxis	Q92974	9181	ARHGEF2	1q21-q22	human	T679	PHOSPHORYLATION	449343	PGVELLLtPREPALP		activity, induced; molecular association, regulation	cytoskeletal reorganization	RhoA(INDUCES)		1968340; 7313810	4	3	18	activates RhoA and as a result regulates actin assembly	
eNOS	Amino Acid Metabolism - arginine and proline; EC 1.14.13.39; Oxidoreductase	P29473	287024	NOS3		cow	Y83	PHOSPHORYLATION	456466	WELGSITyDTLCAQS		enzymatic activity, induced				6716; 1713150	4	1	0		
Cdc25C	EC 3.1.3.48; Motility/polarity/chemotaxis; PHOSPHATASE; Protein phosphatase, dual-specificity	P30307	995	CDC25C	5q31	human	S198	PHOSPHORYLATION	448636	SDELMEFsLKDQEAK	M-inducer_phosp	intracellular localization				1833	3	0	1		
Ctip	EC 3.1.-.-; Transcription, coactivator/corepressor	Q99708	5932	RBBP8	18q11.2	human	T847	PHOSPHORYLATION	7113805	FRYIPPNtPENFWEV	SAE2		cell cycle regulation; chromatin organization, altered			6804217	1	0	1		
JNK2	EC 2.7.11.24; KINASE; Kinase, protein; Protein kinase, CMGC; Protein kinase, Ser/Thr (non-receptor)	Q9WTU6	26420	Mapk9		mouse	S129	PHOSPHORYLATION	456485	ELDHERMsYLLYQML	Pkinase	enzymatic activity, induced				6735	1	0	0		
P2RY1	GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR	P47900	5028	P2RY1	3q25.2	human	T358	PHOSPHORYLATION	10897605	QSKSEDMtLNILPEF		receptor internalization, altered				10353925	1	0	0	important for beta-arrestin 2 translocation to the plasma membrane	
PAK2	EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, STE; Protein kinase, Ser/Thr (non-receptor)	Q29502	100009535	PAK2		rabbit	S141	PHOSPHORYLATION	448295	TVKQKYLsFTPPEKD		enzymatic activity, induced		Cdc42 iso1(DISRUPTS)		7797; 6702318	6	40	77		
NPM1	RNA binding protein; Translation	P06748	4869	NPM1	5q35.1	human	K267	ACETYLATION	461149	SLPKVEAkFINYVKN	TFIIF_alpha	molecular association, regulation; intracellular localization	transcription, altered	H3(INDUCES)		8156707	1	5	119	K212/215/229/230/257/267/292R  mutant	
AS160	GTPase activating protein, Rab	O60343	9882	TBC1D4	13q22.2	human	S341	PHOSPHORYLATION	455922	QPRRRHAsAPSHVQP	PID	molecular association, regulation		14-3-3 epsilon(INDUCES)		14058615	7	23	294	multiple sites (6P) mutant	
vimentin	Cytoskeletal protein; Motility/polarity/chemotaxis	P20152	22352	Vim		mouse	S25	PHOSPHORYLATION	455453	SGTSSRPsSNRSYVT	Filament_head; DUF2464		cytoskeletal reorganization			2057	2	5	1		
4E-BP1	Translation; Translation initiation	Q13541	1978	EIF4EBP1	8p12	human	T70	PHOSPHORYLATION	447528	RNSPVTKtPPRDLPT	eIF_4EBP	molecular association, regulation; activity, inhibited; phosphorylation	translation, altered	eIF4E(DISRUPTS)		6411; 4805; 2063; 444; 29676408	38	23	9	4E-BP1 disassociates from eIF-4E during mitosis, when 4E-BP1 is phosphorylated at S64 and T69. ; T41 and T50 phosphorylation is required for stepwise phosphorylation of T37, T46, S65, and S70	
PKCE	EC 2.7.11.13; KINASE; Kinase, protein; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor)	Q02156	5581	PRKCE	2p21	human	S729	PHOSPHORYLATION	448789	QEEFKGFsYFGEDLM	Pkinase_C	molecular association, regulation; intracellular localization; enzymatic activity, induced		AKAP9(DISRUPTS)		1173; 5121504	15	9	5	AKAP9 anchors hypophosphorylated PKCE at Golgi/centrosome for phosphorylaton.	
NSFL1C	Vesicle protein	Q9UNZ2	55968	NSFL1C	20p13	human	S140	PHOSPHORYLATION	455619	AVERVTKsPGETSKP		intracellular localization	cytoskeletal reorganization			5648	1	15	4		
STI1	Chaperone	Q60864	20867	Stip1		mouse	T198	PHOSPHORYLATION	465576	DEEEEAAtPPPPPPP		intracellular localization				8653	2	1	2		
PDE10A iso2	EC 3.1.4.17; EC 3.1.4.35; Nucleotide Metabolism - purine; Phosphodiesterase	Q9Y233-2	10846	PDE10A	6q26	human	T16	PHOSPHORYLATION	478273	ASCFRRLtECFLSPS		intracellular localization; palmitoylation				15026107; 8720	2	0	0		
HS1	Adaptor/scaffold; Motility/polarity/chemotaxis	P49710	15163	Hcls1		mouse	Y388	PHOSPHORYLATION	451635	EPETEPDyEDVGELD		molecular association, regulation; intracellular localization		ITK(INDUCES)		12023001; 3743	7	1	38		
14-3-3 zeta	Adaptor/scaffold; Motility/polarity/chemotaxis	P63101	22631	Ywhaz		mouse	S58	PHOSPHORYLATION	449833	VVGARRSsWRVVSSI	14-3-3; FliM	molecular association, regulation	apoptosis, induced	14-3-3 zeta(DISRUPTS)		17482901; 2375	11	1	5		
CDK5	EC 2.7.1.37; EC 2.7.11.22; KINASE; Kinase, protein; Protein kinase, CMGC; Protein kinase, Ser/Thr (non-receptor)	Q00535	1020	CDK5	7q36	human	S159	PHOSPHORYLATION	448021	GIPVRCYsAEVVTLW	Pkinase	enzymatic activity, induced				1008	5	0	0	Cdk5 is activated after phosphorylation by CK1 in vitro. 	
Jun	Transcription factor	P05412	3725	JUN	1p32-p31	human	S73	PHOSPHORYLATION	447943	VGLLKLAsPELERLI	Jun	activity, induced; molecular association, regulation; protein stabilization	transcription, induced; transcription, altered; cell growth, altered	JNK1(DISRUPTS); Pin1(INDUCES)	DNA(DISRUPTS)	4843006; 7397639; 6324; 6403; 2333; 4652; 5827; 14654313; 1022; 6417; 641; 4031; 7324120; 7124704	64	34	16	induced by ERK7 activity	
HePTP	EC 3.1.3.48; Motility/polarity/chemotaxis; PHOSPHATASE; Protein phosphatase, tyrosine (non-receptor)	P35236	5778	PTPN7	1q32.1	human	T66	PHOSPHORYLATION	448311	EPICSVNtPREVTLH		molecular association, regulation; protein conformation		ERK2(DISRUPTS); P38A(DISRUPTS)		2587; 6995	1	3	47		
KOR-1	GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR	P34975	29335	Oprk1		rat	Y87	PHOSPHORYLATION	3082310	VMFVIIRyTKMKTAT	EVC2_like; 7tm_1	activity, induced				8600	1	0	0	potentiation for KIR3 activation	
JunB	Motility/polarity/chemotaxis; Transcription factor	P17275	3726	JUNB	19p13.2	human	S251	PHOSPHORYLATION	465702	QTVPEARsRDATPPV	Jun; HAP1_N; Jnk-SapK_ap_N	protein degradation		FBXW7(INDUCES)		27938601	1	19	6	mitosis progression and chromatid cohesion	
TNNI3	Actin binding protein; Motility/polarity/chemotaxis; Motor protein	P19429	7137	TNNI3	19q13.4	human	T31	PHOSPHORYLATION	6796401	SNYRAYAtEPHAKKK	Troponin-I_N	molecular association, regulation; protein conformation		C16orf82(INDUCES); TNC(INDUCES)		6702300	1	0	0		
PPP1R3A	Membrane protein, integral; Protein phosphatase, regulatory subunit	Q00756	100009140	RG1		rabbit	S67	PHOSPHORYLATION	449321	SSGGRRVsFADNFGF		molecular association, regulation		PPP1CA(DISRUPTS)		8514	5	2	0		
Lasp-1	Actin binding protein; Motility/polarity/chemotaxis	Q14847	3927	LASP1	17q11-q21.3	human	S146	PHOSPHORYLATION	448836	MEPERRDsQDGSSYR		molecular association, regulation; intracellular localization		LPP(INDUCES); zyxin(DISRUPTS)		2002; 25573526	3	13	108	phosphorylation induces localization in the nucleus; Expression of the Lasp-1 S146D mutant resulted in nearly complete relocalization of the protein to the cytosol and reduced migration of the cells	
Myb	DNA binding protein; Transcription factor	P06876	17863	Myb		mouse	T486	PHOSPHORYLATION	1308921	PLKMLPQtPSHAVED	Cmyb_C	protein degradation				1172847	2	0	0	stress-induced degredation	
PDGFRB	EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Protein kinase, TK; Protein kinase, tyrosine (receptor)	P05622	18596	Pdgfrb		mouse	Y578	PHOSPHORYLATION	447521	VSSDGHEyIYVDPVQ		molecular association, regulation		PLCG1(INDUCES)		6290	11	1	0		
pyrin		O15553	4210	MEFV	16p13.3	human	S209	PHOSPHORYLATION	455898	RLRRNASsAGRLQGL		molecular association, regulation; intracellular localization		14-3-3 theta(INDUCES)		6362	1	0	0		
CREB	DNA binding protein; Transcription factor	P15337	81646	Creb1		rat	S129	PHOSPHORYLATION	450092	QKRREILsRRPSYRK	pKID		transcription, induced			2832; 2851; 2681	10	0	2	Ser to Ala substitution of residue 129 impairs cAMP-induced transcriptional response; PTH induced	
PGC-1 alpha	Nuclear receptor co-regulator; Transcription, coactivator/corepressor	O70343	19017	Ppargc1a		mouse	T256	PHOSPHORYLATION	13861600	HAQAKPTtLSLPLTP		intracellular localization	transcription, induced			13354730	1	0	0		
PJA2	EC 6.3.2.-; EC 6.3.2.19; Ligase; UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase	O43164	9867	PJA2	5q21.3	human	S342	PHOSPHORYLATION	18713700	RHEAKQRsVQRWREA		ubiquitination; enzymatic activity, induced	signaling pathway regulation			18668233	1	0	0	S342A/T389A mutant fails to ubiquitylate PKAR2A in vitro	
SPHK2	EC 2.7.1.-; EC 2.7.1.91; Kinase, lipid; Lipid Metabolism - sphingolipid	Q9NRA0	56848	SPHK2	19q13.2	human	S419	PHOSPHORYLATION	486446	AHSPLHRsVSDLPLP		intracellular localization				12166	1	0	0	regulation of nuclear shuttling	
FAM125B	Vesicle protein	Q9H7P6	89853	FAM125B	9q33.3	human	Y243	PHOSPHORYLATION	15167001	STRTDYEyQHSNLYA	DUF2464	protein degradation; ubiquitination				15026112	1	1	1		
C5aR	GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR	P21730	728	C5AR1	19q13.3-q13.4	human	S334	PHOSPHORYLATION	448819	SVVRESKsFTRSTVD		molecular association, regulation; receptor desensitization, altered		ARRB1(INDUCES); ARRB2(INDUCES)		1995; 9155; 1994	4	0	2	induces translocation of beta-arrestin to the plasma membrane	
HSF4	Cell development/differentiation; DNA binding protein; Transcription, coactivator/corepressor	Q9ULV5	3299	HSF4	16q21	human	S298	PHOSPHORYLATION	4037600	LLKEEPAsPGGDGEA	Vert_HS_TF	molecular association, regulation; activity, inhibited	transcription, inhibited	Daxx(INDUCES)		17482914	2	0	0		
SP1	C2H2-type zinc finger protein; DNA binding protein; Transcription factor	P08047	6667	SP1	12q13.1	human	S732	PHOSPHORYLATION	2535903	PLDSGAGsEGSGTAT		protein degradation				2425224	2	0	0		
beclin 1	Adaptor/scaffold; Autophagy; Membrane protein, peripheral	Q14457	8678	BECN1	17q21	human	T119	PHOSPHORYLATION	6406000	LSRRLKVtGDLFDIM	APG6	activity, induced; molecular association, regulation		Bcl-2(DISRUPTS); Bcl-xL(DISRUPTS)		7543531; 6331323	2	0	0		
ER-beta	DNA binding protein; Nuclear receptor	O08537	13983	Esr2		mouse	S61	O-GlcNAc	5148302	MNYSVPSsTGNLEGG	ERbeta_N; Oest_recep	protein conformation				8930	1	1	0		
DVL1	Inhibitor protein	P51141	13542	Dvl1		mouse	S139	PHOSPHORYLATION	470073	DNETGTEsMVSHRRE		activity, induced	cell differentiation, altered			8945	1	0	0	contributes to B-catenin-dependent Wnt signaling;  mutation of this site inhibits double axis formation in Xenopus embryos	
SGK1	EC 2.7.11.1; KINASE; Kinase, protein; Motility/polarity/chemotaxis; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor)	O00141	6446	SGK1	6q23	human	S422	PHOSPHORYLATION	448429	AEAFLGFsYAPPTDS	Pkinase_C	enzymatic activity, induced	apoptosis, inhibited			5309413; 1269; 1267; 7483301; 4313604; 5309414	19	0	0	induce activation of chloride channel CLCN2; S422A mutation shows similar ENaC ion channel current as parental cell line, but a dominant negative mutant (D222A) significantly decreases channel current. ; HSP90 is required for SGK kinase activity.; adhesion dependent activation 	
MEK1	EC 2.7.12.2; KINASE; Kinase, protein; Protein kinase, STE; Protein kinase, dual-specificity	P31938	26395	Map2k1		mouse	T286	PHOSPHORYLATION	448286	VEGDAAEtPPRPRTP	Pkinase	enzymatic activity, inhibited				1162	6	3	16		
NHERF	Adaptor/scaffold; Motility/polarity/chemotaxis	O14745	9368	SLC9A3R1	17q25.1	human	S77	PHOSPHORYLATION	957200	ETHQQVVsRIRAALN	PDZ; DUF1537	molecular association, regulation; intracellular localization		SLC34A1(DISRUPTS); ADRA2B(DISRUPTS)		14780509; 762733	4	0	0		
GABRB2	Channel, chloride; Channel, ligand-gated; Membrane protein, integral; Membrane protein, multi-pass	P63138	25451	Gabrb2		rat	S434	PHOSPHORYLATION	449329	SRLRRRAsQLKITIP	Neur_chan_memb	intracellular localization				2187	1	0	1		
ATF-1	Transcription factor	P18846	466	ATF1	12q13	human	S41	PHOSPHORYLATION	15725600	SLSESEEsQDSSDSI		molecular association, regulation; phosphorylation		CBP(DISRUPTS)		15658718	1	0	0	primes for S47/S50/S51 phosphorylation	
SLAP-130	Adaptor/scaffold	O15117	2533	FYB	5p13.1	human	Y595	PHOSPHORYLATION	452094	IEDDQEVyDDVAEQD	Ycf1	molecular association, regulation	cell motility, altered; cell adhesion, altered	SLP76(INDUCES)		15020906; 4036	3	1	60	promotes adhesion to ICAM-1; promotes cell migration	
P38A	EC 2.7.1.37; EC 2.7.11.24; KINASE; Kinase, protein; Protein kinase, CMGC; Protein kinase, Ser/Thr (non-receptor)	Q16539	1432	MAPK14	6p21.3-p21.2	human	T180	PHOSPHORYLATION	447970	RHTDDEMtGYVATRW	Pkinase	activity, induced; molecular association, regulation; phosphorylation; enzymatic activity, induced	cell cycle regulation; apoptosis, altered; cell motility, altered; cytoskeletal reorganization; cell adhesion, altered	PPP2CA(NOT_REPORTED); MEK1(NOT_REPORTED); Nck1(INDUCES); Fyn(INDUCES); P38A(INDUCES)		1268100; 7036; 1173013; 5121519; 1172869; 6756; 715; 5720; 2624803; 4313623; 7613744	305	34	1501		
Kv3.4	Channel, potassium; Membrane protein, integral; Membrane protein, multi-pass	Q03721	3749	KCNC4	1p21	human	S15	PHOSPHORYLATION	451077	SSYRGRKsGNKPPSK	Potassium_chann	receptor inactivation, altered; protein conformation; activity, inhibited				13251000; 3296	2	0	0		
DBF4	Cell cycle regulation; Protein kinase, regulatory subunit	Q9UBU7	10926	DBF4	7q21.3	human	T449	PHOSPHORYLATION	23010416	DDIRQNFtQLPLHKN			cell cycle regulation			22965803	1	0	0	DBF4 phosphorylaion is important for supressing DNA replication.	
TRF1	DNA binding protein	P54274	7013	TERF1	8q21.11	human	T344	PHOSPHORYLATION	3793900	KKERRVGtPQSTKKK		phosphorylation				3301227	1	0	0	stimulates phosphorylation of residue S435	
RARG iso2	DNA binding protein; Nuclear receptor	P18911-2	19411	Rarg		mouse	S66	PHOSPHORYLATION	455543	SEEMVPSsPSPPPPP		activity, induced; protein degradation	transcription, altered			5430	2	0	0		
ODFP1	Cancer Testis Antigen (CTA)	P21769	4956	Odf1		rat	S193	PHOSPHORYLATION	2859801	SPCYPCTsPCNPCNP		molecular association, regulation		RNF38(INDUCES)		2856308	1	0	0		
IQGAP1	GTPase activating protein, Ras; Motility/polarity/chemotaxis	P46940	8826	IQGAP1	15q26.1	human	S1443	PHOSPHORYLATION	454416	DKMKKSKsVKEDSNL	RasGAP_C	molecular association, regulation; protein conformation; phosphorylation	cytoskeletal reorganization	Cdc42 iso1(DISRUPTS)		4283; 5505; 18410838	2	6	1	augments EGF-mediated phosphorylation and activation of EGFR; neurite outgrowth in N1E-115 neurons	
HDAC6	Deacetylase; EC 3.5.1.98; Ubiquitin conjugating system	Q9UBN7	10013	HDAC6	Xp11.23	human	Y570	PHOSPHORYLATION	12127406	SSNFDSIyICPSTFA	Hist_deacetyl	enzymatic activity, inhibited				12021323	1	0	1		
InsR	EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Protein kinase, TK; Protein kinase, tyrosine (receptor)	P06213	3643	INSR	19p13.3-p13.2	human	S1333	PHOSPHORYLATION	451591	NVPLDRSsHCQREEA		enzymatic activity, inhibited				3719	2	0	0		
vimentin	Cytoskeletal protein; Motility/polarity/chemotaxis	P08670	7431	VIM	10p13	human	S73	PHOSPHORYLATION	449025	SAVRLRSsVPGVRLL	Filament_head; DUF2464	molecular association, regulation; phosphorylation	cytoskeletal reorganization	vimentin(DISRUPTS)		7571; 2214	11	26	31	increases phosphorylation of S5, S7, S8, S9, S10	
HuR	RNA binding protein	Q15717	1994	ELAVL1	19p13.2	human	S158	PHOSPHORYLATION	478356	FIRFDKRsEAEEAIT	RRM_1	molecular association, regulation; intracellular localization; phosphorylation	translation, altered; RNA stability, altered	PKCA(INDUCES)	RNA(INDUCES)	28723110; 9614	3	0	0	ELAV1 is exported from the nucleus after phosphorylation by PKCA. ; increased binding to U-rich RNA but not AU-rich sequences	
arfaptin 2	GTPase activating protein, Rac/Rho; Motility/polarity/chemotaxis	P53365	23647	ARFIP2	11p15	human	S260	PHOSPHORYLATION	455884	GTRGRLEsAQATFQA	Arfaptin	intracellular localization				6345	1	1	4	phosphorylation of site by Akt1 has a neuroprotective effect in Huntington's disease.	
IREM-1	Immunoglobulin superfamily; Membrane protein, integral; Receptor, misc.	Q8TDQ1	146722	CD300LF	17q25.1	human	Y263	PHOSPHORYLATION	474549	AEDQEPTyCNMGHLS		activity, induced; molecular association, regulation		PIK3R1(INDUCES)		9304	1	0	0	involved in rat basophilic leukemia cell degranulation	
PKD1	Autophagy; EC 2.7.11.13; KINASE; Kinase, protein; Motility/polarity/chemotaxis; Protein kinase, CAMK; Protein kinase, Ser/Thr (non-receptor)	Q15139	5587	PRKD1	14q11	human	S738	PHOSPHORYLATION	448589	ARIIGEKsFRRSVVG	Pkinase	molecular association, regulation; intracellular localization; enzymatic activity, induced	cell differentiation, altered; cell motility, altered; transcription, altered	IKKB(INDUCES); ASK1(INDUCES); PKCD(INDUCES); JNK1(INDUCES)		18410803; 5785; 3615; 5014002; 5762; 4752; 2512009; 4248203	48	7	14		
PDX1	DNA binding protein; Transcription factor	P52946	18609	Pdx1		mouse	S269	PHOSPHORYLATION	11279404	LPSGLSVsPQPSSIA		protein stabilization; intracellular localization				27565310; 15026103	3	2	0		
BRSK1	EC 2.7.11.1; EC 2.7.11.26; KINASE; Kinase, protein; Protein kinase, CAMK; Protein kinase, Ser/Thr (non-receptor)	BAG28183	499073	Brsk1		rat	T189	PHOSPHORYLATION	456027	VGDSLLEtSCGSPHY	Pkinase	enzymatic activity, induced				21686208; 2451819	6	1	0		
SCYE1	Motility/polarity/chemotaxis	Q12904	9255	AIMP1	4q24	human	S140	PHOSPHORYLATION	12440055	KKEKKQQsIAGSADS		molecular association, regulation		GRP94(DISRUPTS)		14562605	1	2	8		
CCNH	Cell cycle regulation	P51946	902	CCNH	5q13.3-q14	human	S5	PHOSPHORYLATION	456230	___MYHNsSQKRHWT		activity, inhibited	transcription, altered; cell growth, altered			12482254	1	1	0		
raptor	Adaptor/scaffold	Q8N122	57521	RPTOR	17q25.3	human	S863	PHOSPHORYLATION	453732	LTQSAPAsPTNKGVH		activity, induced; protein conformation; phosphorylation				22343619; 7543503; 11189923	9	54	6	required for Rheb-stimulated phosphorylation of S855 and S859;  necessary for phosphorylation of S859; mTORC1 activation; activates mTOR towards p70S6K1 in response to insulin	
SPT5	Transcription, coactivator/corepressor	O00267	6829	SUPT5H	19q13	human	T799	PHOSPHORYLATION	458818	PLQDGSRtPHYGSQT	CTD		transcription, altered			7460	1	4	24	required for c-fos induction and activation in vivo	
MLF1IP	Cell cycle regulation	Q71F23	79682	MLF1IP	4q35.1	human	T78	PHOSPHORYLATION	471408	FDPPLHStAIYADEE		protein degradation	cell cycle regulation; cell growth, altered	PLK1(INDUCES)		9116	2	1	0	p-T78 peptides precipitated with Pl1K. Kinase activity of Plk1 is necessary for the in vivo interaction. The S77- T78 dependent interaction is sufficient to target Plk1 to the kinetochores. P-T78 dependent PBIP1 function is required for chromosome segregation, and is important for activation of spindle assembly checkpoint.	
Chk1	EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, CAMK; Protein kinase, Ser/Thr (non-receptor)	O14757	1111	CHEK1	11q24.2	human	S280	PHOSPHORYLATION	447831	AKRPRVTsGGVSESP		protein degradation; molecular association, regulation; intracellular localization; enzymatic activity, inhibited	cell cycle regulation			6168; 4105	7	14	130		
GABRG2	Channel, chloride; Channel, ligand-gated; Membrane protein, integral; Membrane protein, multi-pass	Q6PW52	29709	Gabrg2		rat	Y411	PHOSPHORYLATION	455817	LQERDEEyGYECLDG	Neur_chan_memb	molecular association, regulation		Src(INDUCES)		6319	7	0	0		
HES1	Cell development/differentiation; Motility/polarity/chemotaxis; Transcription factor	Q04666	29577	Hes1		rat	S263	PHOSPHORYLATION	23298200	SVGPNAVsPSSGSSL		protein stabilization				23260368	1	0	0	 decreases AMPA-evoked calcium influx; supresses GluR1 expression at the synaptic membrane	
GluR2	Channel, calcium; Channel, ligand-gated; Membrane protein, integral; Membrane protein, multi-pass	P23819	14800	Gria2		mouse	Y876	PHOSPHORYLATION	452173	YKEGYNVyGIESVKI		molecular association, regulation		IQSEC1(DISRUPTS)		4090; 15031326	2	3	110	GLuR2/IQSEC1 mediated long-term synaptic depression	
SIRT1	Apoptosis; DEACETYLASE; Deacetylase; EC 3.5.1.-; Nuclear receptor co-regulator	Q923E4	93759	Sirt1		mouse	S651	PHOSPHORYLATION	6855924	GAEVYSDsEDDVLSS		enzymatic activity, induced	apoptosis, inhibited			9980406	2	0	0	deacetylates p53 K382 and NFkB-p65	
KCNN4	Channel, potassium; Membrane protein, integral; Membrane protein, multi-pass	Q9QYW1	65206	Kcnn4		rat	T348	PHOSPHORYLATION	452146	KMLAAIHtFRQVRLK	CaMBD	activity, inhibited				4074	1	0	0		
P38A	EC 2.7.1.37; EC 2.7.11.24; KINASE; Kinase, protein; Protein kinase, CMGC; Protein kinase, Ser/Thr (non-receptor)	P47811	26416	Mapk14		mouse	Y182	PHOSPHORYLATION	447971	TDDEMTGyVATRWYR	Pkinase	molecular association, regulation; enzymatic activity, induced	transcription, altered	PKCZ(INDUCES)		4324810; 6947; 7857; 5121506; 5430; 4862602	310	68	3676		
STLK3	EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, STE; Protein kinase, Ser/Thr (non-receptor)	Q9UEW8	27347	STK39	2q24.3	human	T231	PHOSPHORYLATION	456505	TRNKVRKtFVGTPCW	Pkinase	enzymatic activity, induced				2195492; 2653903	9	3	36		
CYLD	EC 3.1.2.15; EC 3.4.19.12; Protease; Ubiquitin conjugating system; Ubiquitin-specific protease	Q80TQ2	74256	Cyld		mouse	S414	PHOSPHORYLATION	4745557	SSENRFHsLPFSLTK		enzymatic activity, inhibited	cell growth, induced			27780800	2	12	22	S418 phosphorylation is necessary to induce IKK-epsilon induced transformation and decreases its deubiquitinase activity.	
NRIF3	Cell adhesion; Motility/polarity/chemotaxis; Nuclear receptor co-regulator; Transcription, coactivator/corepressor	Q13352	23421	ITGB3BP	1p31.3	human	S28	PHOSPHORYLATION	2840505	SKITRKKsVITYSPT		activity, induced; molecular association, regulation	transcription, induced; cell growth, altered	ER-alpha(INDUCES)		2831765	1	0	0		
JunB	Motility/polarity/chemotaxis; Transcription factor	P24898	24517	Junb		rat	S23	PHOSPHORYLATION	1814002	AAAGYGRsPGSLSLH	Jun	protein degradation	cell cycle regulation; transcription, altered			1813900	1	3	0	Phosphorylation promoted degradation during the G2-M transition.  JunB inhibition of cyclin D1 transcription is relieved by JunB protein degradation.	
CAD	Amino Acid Metabolism - alanine, aspartate and glutamate; EC 2.1.3.2; EC 3.5.2.3; EC 6.3.5.5; Hydrolase; KINASE; Ligase; Nucleotide Metabolism - pyrimidine; Transferase	P27708	790	CAD	2p22-p21	human	S1859	PHOSPHORYLATION	451247	PPRIHRAsDPGLPAE		enzymatic activity, induced				27592800	3	40	83		
DAPK3	EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, CAMK; Protein kinase, Ser/Thr (non-receptor)	O43293	1613	DAPK3	19p13.3	human	T180	PHOSPHORYLATION	454890	EFKNIFGtPEFVAPE	Pkinase	enzymatic activity, induced				4344	1	0	0		
CDH1	Cell adhesion; Membrane protein, integral; Motility/polarity/chemotaxis; UBIQUITIN LIGASE; Ubiquitin ligase	P09803	12550	Cdh1		mouse	S853	PHOSPHORYLATION	465566	SLSSLNSsESDQDQD	Cadherin_C	molecular association, regulation	cell adhesion, altered	CTNNB1(INDUCES)		8025	1	0	0		
ZAP70	EC 2.7.10.2; KINASE; Kinase, protein; Protein kinase, TK; Protein kinase, tyrosine (non-receptor)	P43403	7535	ZAP70	2q12	human	Y492	PHOSPHORYLATION	447504	ALGADDSyYTARSAG	Pkinase_Tyr	enzymatic activity, inhibited	transcription, altered			808	6	12	433	inhibits Ca(2+) mobilization	
SF2	RNA binding protein; RNA splicing; Spliceosome	NP_001103022	689890	Sfrs1		rat	S227	PHOSPHORYLATION	2303915	NSRSRSYsPRRSRGS	Corona_nucleoca; DUF1509; DUF1777	intracellular localization				5007900	3	11	2	inhibits tau exon 10 inclusion, and increases 3R-tau production 	
NHE1	Membrane protein, integral; Membrane protein, multi-pass; Motility/polarity/chemotaxis; Transporter	P26431	24782	Slc9a1		rat	S775	PHOSPHORYLATION	475073	MIRSKEPsSPGTDDV		activity, induced				9201026	5	2	0		
PKACA	EC 2.7.11.11; KINASE; Kinase, protein; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor)	P05132	18747	Prkaca		mouse	Y331	PHOSPHORYLATION	15230353	DTSNFDDyEEEEIRV	Pkinase_C	enzymatic activity, inhibited	transcription, inhibited			27619354	2	1	1	inhibition of the PKA and CREB-stimulated expression of the BCL2 gene	
CDK2	EC 2.7.11.22; KINASE; Kinase, protein; Protein kinase, CMGC; Protein kinase, Ser/Thr (non-receptor)	P24941	1017	CDK2	12q13	human	T160	PHOSPHORYLATION	447739	GVPVRTYtHEVVTLW	Pkinase	activity, induced; protein conformation; enzymatic activity, induced	cell cycle regulation; chromatin organization, altered	CCNA1(INDUCES); CDKN3(DISRUPTS)		2610806; 5397; 4835207; 5456; 5187; 6078; 633; 4646; 4623; 13264500; 5885	36	19	224	centrosome amplification	
RAC1	G protein; G protein, monomeric, Rho; Motility/polarity/chemotaxis	P63000	5879	RAC1	7p22	human	Y64	PHOSPHORYLATION	475227	DTAGQEDyDRLRPLS	Ras	molecular association, regulation	cell adhesion, inhibited	PAK1(DISRUPTS); RhoGDI alpha(INDUCES); ARHGEF7(DISRUPTS)		25185215	1	1	33	inhibits cell spreading 	
PLB	Inhibitor protein; Membrane protein, integral	P26678	5350	PLN	6q22.1	human	T17	PHOSPHORYLATION	448115	SAIRRAStIEMPQQA	Phospholamban; Baculo_11_kDa; BatA	molecular association, regulation; protein conformation		SERCA2(DISRUPTS); ATP2A1(DISRUPTS)		6115902; 5121512	42	6	53		
ARFGEF1	Guanine nucleotide exchange factor, ARF	Q9Y6D6	10565	ARFGEF1	8q13	human	S883	PHOSPHORYLATION	459627	EIAGKKIsMKETKEL		intracellular localization				7704	1	0	1		
RAF1	EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, Ser/Thr (non-receptor); Protein kinase, TKL	P04049	5894	RAF1	3p25	human	Y340	PHOSPHORYLATION	447749	RGQRDSSyYWEIEAS		molecular association, regulation; enzymatic activity, inhibited; phosphorylation; enzymatic activity, induced		RAF1(DISRUPTS)		6526; 8397; 3340200; 6528; 2684; 6052; 2940; 12068402; 6115934	23	1	1		
Bax	Apoptosis; Membrane protein, integral; Mitochondrial	Q07812	581	BAX	19q13.3-q13.4	human	T167	PHOSPHORYLATION	465510	GLLSYFGtPTWQTVT		activity, induced; intracellular localization; phosphorylation	apoptosis, induced			7996; 8296	2	0	0		
NFAT4	DNA binding protein; Transcription factor	Q12968	4775	NFATC3	16q22.2	human	S215	PHOSPHORYLATION	11507604	PLTSPGGsPGGCPGE		intracellular localization				10274612	1	0	0	cytoplasmic localization (inhibition of nuclear localization)	
ARHGEF2	Guanine nucleotide exchange factor, Rac/Rho; Motility/polarity/chemotaxis	B2DCZ9		ARHGEF2		pig	T653	PHOSPHORYLATION	449343	PGVELLLtSREPALP		activity, induced; molecular association, regulation		RhoA(INDUCES)		7313810	4	3	18		
PKCT	EC 2.7.11.13; KINASE; Kinase, protein; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor)	Q04759	5588	PRKCQ	10p15	human	Y90	PHOSPHORYLATION	448588	SETTVELySLAERCR		molecular association, regulation; intracellular localization; enzymatic activity, induced	transcription, altered		Other(INDUCES)	1173014; 1318	3	0	0		
PAK1	EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, STE; Protein kinase, Ser/Thr (non-receptor)	O88643	18479	Pak1		mouse	T109	PHOSPHORYLATION	14150103	QWARLLQtSNITKSE	PBD	enzymatic activity, inhibited				14058612	1	1	0	in vitro	
4E-BP1	Translation; Translation initiation	Q13541	1978	EIF4EBP1	8p12	human	T37	PHOSPHORYLATION	447497	PPGDYSTtPGGTLFS	eIF_4EBP	molecular association, regulation; activity, inhibited; phosphorylation	translation, altered; cell growth, induced	eIF4E(DISRUPTS); 4E-BP1(DISRUPTS)		4805; 2063; 446; 7483316; 28854800; 29676408	89	24	87	T41 and T50 act as priming sites for T37/46	
eIF2B-epsilon	Translation; Translation initiation	Q64350	192234	Eif2b5		rat	S713	PHOSPHORYLATION	449908	REAEEESsDDD____	W2	molecular association, regulation		eIF2-alpha(INDUCES)		1618	3	4	2		
DYNLT1	Microtubule binding protein; Motility/polarity/chemotaxis; Motor protein	Q9Z336	83462	Dynlt1		rat	T94	PHOSPHORYLATION	456225	SSTDGSCtVRWENKT	Tctex-1	molecular association, regulation				6667	4	0	0		
Kv7.2	Channel, potassium; Membrane protein, integral; Membrane protein, multi-pass	O43526	3785	KCNQ2	20q13.3	human	T217	PHOSPHORYLATION	457689	RMDRRGGtWKLLGSV	Ion_trans; TM	activity, induced				7320	2	1	0		
caldesmon	Actin binding protein	Q62736	25687	Cald1		rat	S527	PHOSPHORYLATION	448466	QSVDKVTsPTKV___		intracellular localization	cytoskeletal reorganization			7289	15	9	0		
APOBEC1	Cell cycle regulation; EC 3.5.4.-; Hydrolase; RNA binding protein; RNA processing	P41238	339	APOBEC1	12p13.1	human	S72	PHOSPHORYLATION	450067	NFIKKFTsERDFHPS	APOBEC_N	enzymatic activity, inhibited				1371	1	0	0		
SLC22A1	Membrane protein, integral; Membrane protein, multi-pass; Transporter	Q63089	24904	Slc22a1		rat	S328	PHOSPHORYLATION	455613	LCLEEDAsEKRSPSF	Sugar_tr	activity, induced				5524	1	0	0	stimulates ASP+ uptake	
Ets-1	DNA binding protein; Motility/polarity/chemotaxis; Transcription factor	P27577	23871	Ets1		mouse	T38	PHOSPHORYLATION	447950	CADVPLLtPSSKEMM			transcription, induced			4894703	9	1	5		
MafA	DNA binding protein; Transcription factor	Q8NHW3	389692	MAFA	8q24.3	human	T134	PHOSPHORYLATION	456029	NPEALNLtPEDAVEA	Maf_N; Zip	protein degradation				7910506	3	2	0		
PDGFRA	EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Protein kinase, TK; Protein kinase, tyrosine (receptor)	P16234	5156	PDGFRA	4q12	human	Y762	PHOSPHORYLATION	448440	SDIQRSLyDRPASYK	Pkinase_Tyr	molecular association, regulation		CDK6(INDUCES); CrkL(INDUCES)		1227	2	10	338		
Akt1	EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor)	P31750	11651	Akt1		mouse	T450	PHOSPHORYLATION	447857	TAQMITItPPDQDDS	Pkinase_C	ubiquitination	translation, altered			15799300	22	0	1	prevents cotranslational Akt ubiquitination	
EphA2	EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Protein kinase, TK; Protein kinase, tyrosine (receptor)	P29317	1969	EPHA2	1p36	human	Y594	PHOSPHORYLATION	450860	TYVDPHTyEDPNQAV		molecular association, regulation; enzymatic activity, induced	cell differentiation, altered; cell motility, altered	VAV2(INDUCES); VAV3(INDUCES)		4254811	3	29	719		
PKD1	Autophagy; EC 2.7.11.13; KINASE; Kinase, protein; Motility/polarity/chemotaxis; Protein kinase, CAMK; Protein kinase, Ser/Thr (non-receptor)	Q15139	5587	PRKD1	14q11	human	S223	PHOSPHORYLATION	455756	RTSSAELsTSAPDEP		molecular association, regulation		14-3-3 beta(INDUCES)		5785	1	0	0		
DNAJC5	Vesicle protein	Q9H3Z4	80331	DNAJC5	20q13.33	human	S10	PHOSPHORYLATION	448129	DQRQRSLsTSGESLY		molecular association, regulation		14-3-3 zeta(INDUCES); 14-3-3 epsilon(INDUCES); 14-3-3 gamma(INDUCES); 14-3-3 eta(INDUCES)		5014013	3	46	321		
PDHA1	Amino Acid Metabolism - valine, leucine and isoleucine biosynthesis; Carbohydrate Metabolism - butanoate; Carbohydrate Metabolism - citrate (TCA) cycle; Carbohydrate Metabolism - glycolysis and gluconeogenesis; Carbohydrate Metabolism - pyruvate; EC 1.2.4.1; Mitochondrial; Oxidoreductase	P08559	5160	PDHA1	Xp22.1	human	S232	PHOSPHORYLATION	448257	NRYGMGTsVERAAAS	E1_dh	enzymatic activity, inhibited				1673; 2509	16	48	7		
p70S6K	EC 2.7.11.-; EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor); Translation	P23443	6198	RPS6KB1	17q23.1	human	S434	PHOSPHORYLATION	448356	SFEPKIRsPRRFIGS		enzymatic activity, induced				2563	25	1	0		
SHP-2	EC 3.1.3.48; Motility/polarity/chemotaxis; PHOSPHATASE; Protein phosphatase, tyrosine (non-receptor)	P35235	19247	Ptpn11		mouse	Y63	PHOSPHORYLATION	455054	IQNTGDYyDLYGGEK	SH2	enzymatic activity, inhibited; phosphorylation	cell growth, altered			4651314	1	12	74		
CAMK2A	EC 2.7.11.17; KINASE; Kinase, protein; Protein kinase, CAMK; Protein kinase, Ser/Thr (non-receptor)	Q9UQM7	815	CAMK2A	5q32	human	T286	PHOSPHORYLATION	447797	SCMHRQEtVDCLKKF		molecular association, regulation; intracellular localization; protein conformation; enzymatic activity, induced	cell growth, altered	MAP2(INDUCES); GIT1(INDUCES); MBP(DISRUPTS); neurogranin(DISRUPTS)		27519668; 6074; 3249408; 1883000; 12558733; 6876	100	21	55	incresed the growth rate of SHSY5Y cells, but not MDA-MB-231 cells	
NUT	Unknown function	Q86Y26	256646	NUT	15q14	human	S1029	PHOSPHORYLATION	13165102	YLLASKLsLSPREHP		intracellular localization				12482422	1	0	0	nuclear-cytoplasmic shuttling	
axin 1	Adaptor/scaffold	O70239	79257	Axin1		rat	S492	PHOSPHORYLATION	451104	SPGPGHRsPDSGHVA	Axin_b-cat_bind		cytoskeletal reorganization			25797201	2	6	5	Phosphorylation regulates responsive to Sema3A induced growth cone collapse.	
TSPYL2	DNA replication; Transcription regulation	Q9H2G4	64061	TSPYL2	Xp11.2	human	S20	PHOSPHORYLATION	3212187	RRLSSSEsPQRDPPP			cell growth, altered			12482268	1	1	7		
ezrin	Cytoskeletal protein; Motility/polarity/chemotaxis	P26040	22350	Ezr		mouse	Y354	PHOSPHORYLATION	448105	LMLRLQDyEQKTKRA	ERM		apoptosis, inhibited; cell growth, altered			3548304	8	3	236		
TOP2A	EC 5.99.1.3; Isomerase	P11388	7153	TOP2A	17q21-q22	human	S1106	PHOSPHORYLATION	448761	DEEENEEsDNEKETE	DNA_topoisoIV	molecular association, regulation; enzymatic activity, induced			DNA(INDUCES)	1932; 6702324	2	20	0		
CD22 iso4	Cell surface; Membrane protein, integral	Q3U0M3	12483	Cd22		mouse	Y843	PHOSPHORYLATION	456699	PEDESIHySELVQFG		molecular association, regulation		SHP-1(INDUCES)		7708800	4	0	5		
4E-BP1	Translation; Translation initiation	Q13541	1978	EIF4EBP1	8p12	human	T41	PHOSPHORYLATION	449366	YSTTPGGtLFSTTPG	eIF_4EBP	phosphorylation	cell growth, induced; translation, induced	eIF4E(DISRUPTS)		28854800; 29676408	2	15	51	T41 and T50 act as priming sites for T37/46; T41A and T50A  mutants inhibited tumor growth and showed more cap-binding.	
KLRF1	Membrane protein, integral; Receptor, misc.	Q9NZS2	51348	KLRF1	12p13.31	human	Y7	PHOSPHORYLATION	17831300	_MQDEERyMTLNVQS		molecular association, regulation		Syk(INDUCES); Lck(INDUCES); ZAP70(INDUCES)		17675021	1	0	0	required for KLRF1-mediated cytotoxicity	
BATF	DNA binding protein; Transcription factor	Q16520	10538	BATF	14q24.3	human	S43	PHOSPHORYLATION	450321	NRIAAQKsRQRQTQK	SR-25; Paramyxo_NS_C; Phlebovirus_NSM; AAA_11; HAP1_N; IncA; Jnk-SapK_ap_N; Seryl_tRNA_N; bZIP_1		transcription, inhibited			2992	1	0	0		
NPM-ALK	Kinase, protein; Protein kinase, TK; Protein kinase, tyrosine (receptor)	AAA58698		NPM/ALK		human	Y338	PHOSPHORYLATION	27275110	FGMARDIyRASYYRK	Pkinase_Tyr	enzymatic activity, induced				11387255	2	2	0		
CYP3A4	Cell surface; Cofactor and Vitamin Metabolism - retinol; EC 1.14.13.-; EC 1.14.13.32; EC 1.14.13.67; EC 1.14.13.97; EC 1.14.14.1; Lipid Metabolism - linoleic acid; Membrane protein, integral; Oxidoreductase; Xenobiotic Metabolism - drug metabolism - cytochrome P450; Xenobiotic Metabolism - drug metabolism - other enzymes; Xenobiotic Metabolism - metabolism by cytochrome P450	P08684	1576	CYP3A4	7q21.1	human	S420	PHOSPHORYLATION	5938007	KFLPERFsKKNKDNI	p450	protein degradation; ubiquitination				5930038; 22463923	2	2	0		
PKCA	EC 2.7.11.13; KINASE; Kinase, protein; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor)	P04409	282001	PRKCA		cow	T495	PHOSPHORYLATION	449890	HMMDGVTtRTFCGTP	Pkinase	enzymatic activity, induced				1884	2	1	10		
CTNNB1	Actin binding protein; Cell adhesion; Motility/polarity/chemotaxis; Nuclear receptor co-regulator; Transcription factor	P35222	1499	CTNNB1	3p21	human	S33	PHOSPHORYLATION	447487	QQQSYLDsGIHSGAT		protein degradation; molecular association, regulation; intracellular localization; activity, inhibited	cytoskeletal reorganization; cell adhesion, altered; transcription, inhibited; transcription, altered; cell growth, altered	CBLL1(INDUCES)		2831779; 14654301; 4829201; 12068405; 14146308; 1732; 6842201; 6842213; 2659803; 8971; 8348	51	3	2	 promotes centrosomal cohesion	
Chk2	EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, CAMK; Protein kinase, Ser/Thr (non-receptor)	O96017	11200	CHEK2	22q12.1	human	T68	PHOSPHORYLATION	447491	SSLETVStQELYSIP	DUF966	molecular association, regulation; intracellular localization; protein conformation; phosphorylation; enzymatic activity, induced	cell cycle regulation; apoptosis, induced; cytoskeletal reorganization	MDC1(INDUCES); Chk2(INDUCES); NBS1(INDUCES); PLK1(INDUCES)		4622; 6559; 2007; 639; 1026; 12176; 6079; 6328010; 1970901; 640; 4835205; 6702307; 1025; 2452301; 14821613; 4549; 6922; 5761	130	2	0		
cofilin 1	Cytoskeletal protein; Motility/polarity/chemotaxis	P18760	12631	Cfl1		mouse	S3	PHOSPHORYLATION	448444	_____MAsGVAVSDG			cytoskeletal reorganization			10001309; 6400	52	32	2	S3 phosphorylation is mediated by FAK and regulates morphology of dendritic spines. 	
Notch 1	Membrane protein, integral; Motility/polarity/chemotaxis; Receptor, misc.; Transcription factor	Q01705	18128	Notch1		mouse	K1771	ACETYLATION	18899505	KVSEASKkKRREPLG		protein stabilization; ubiquitination				18899000	1	1	0		
HER2	EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Protein kinase, TK; Protein kinase, tyrosine (receptor)	P04626	2064	ERBB2	17q12	human	Y1112	PHOSPHORYLATION	448674	DPSPLQRySEDPTVP		protein degradation; molecular association, regulation		Cbl(INDUCES)		1075	6	2	1		
IRS1	Adaptor/scaffold; Motility/polarity/chemotaxis	P35570	25467	Irs1		rat	Y608	PHOSPHORYLATION	447555	NLHTDDGyMPMSPGV		molecular association, regulation		PIK3R1(INDUCES)		7397638; 3512	17	7	298		
AFAP	Adaptor/scaffold	Q8N556	60312	AFAP1	4p16	human	Y451	PHOSPHORYLATION	475079	TDPEALHyDYIDVEM		molecular association, regulation		Src(INDUCES)		4664	1	0	0	Src Y529F Src mutant	
cortactin	Actin binding protein; Cytoskeletal protein; Motility/polarity/chemotaxis	Q60598	13043	Cttn		mouse	Y466	PHOSPHORYLATION	447703	TYTSEPVyETTEAPG		molecular association, regulation	cell motility, induced; cytoskeletal reorganization	smMLCK(INDUCES); N-WASP(INDUCES)		3904; 25712657; 8392; 11502	16	3	10	invadopodia formation and extracellular matrix degredation; Tyr to Phe mutation of this site prevents FAK-mediated FA turnover	
pleckstrin	Lipid binding protein	P08567	5341	PLEK	2p13.3	human	T114	PHOSPHORYLATION	478034	QKFARKStRRSIRLP		activity, induced				11484402	1	1	129		
AhR	DNA binding protein; Nuclear receptor; Transcription factor	P35869	196	AHR	7p15	human	S68	PHOSPHORYLATION	451013	INKLDKLsVLRLSVS	HLH	intracellular localization				3263	1	0	0		
Jun	Transcription factor	P17325	24516	Jun		rat	S73	PHOSPHORYLATION	447943	VGLLKLAsPELERLI	Jun	activity, induced; protein stabilization	transcription, altered; cell growth, altered			1676; 4914020	64	34	16		
Mpl	Membrane protein, integral; Receptor, cytokine	P40238	4352	MPL	1p34	human	K573	UBIQUITINATION	11956705	SLLEILPkSSERTPL		protein degradation	cell growth, inhibited			11387288	1	0	0		
Srcasm	Adaptor/scaffold	Q923U0	71943	Tom1l1		mouse	Y440	PHOSPHORYLATION	2263200	GDLQPPNyYEVMEFD		molecular association, regulation		PIK3R1(INDUCES)		3437	1	0	3		
MEGF10	Membrane protein, integral	Q6DIB5	70417	Megf10		mouse	Y1061	PHOSPHORYLATION	478426	PARRDSPyAEINNST			cell cycle regulation; cell motility, altered			2790302	0	3	7		
STAT5A	DNA binding protein; Motility/polarity/chemotaxis; Transcription factor	P42230	20850	Stat5a		mouse	S127	PHOSPHORYLATION	456898	VREANNCsSPAGVLV		phosphorylation	transcription, induced		DNA(INDUCES)	6895	1	1	0	Phosphorylation of S127 or S128 is required for transcription.  Phosphorylation of S127/S128 required for phosphorylation on Y694 and binding of DNA.	
TAZ	Transcription, coactivator/corepressor	Q9EPK5	97064	Wwtr1		mouse	Y316	PHOSPHORYLATION	27138200	SGLGLGCySVPTTPE		molecular association, regulation	transcription, inhibited	TAZ(INDUCES)		27132466	1	0	0	 Y316 TAZ negatively regulates SL6A12 and SLC5A3 gene expression; luciferase reporter	
PCYT1A	EC 2.7.7.15; Lipid Metabolism - glycerophospholipid; Transferase	P19836	140544	Pcyt1a		rat	S315	PHOSPHORYLATION	451321	GRMLQAIsPKQSPSS		enzymatic activity, inhibited				5209	2	33	12		
GTF2I iso2	DNA binding protein; Transcription, coactivator/corepressor	P78347-2	2969	GTF2I	7q11.23	human	S743	PHOSPHORYLATION	457075	GVPFRRPsTFGIPRL	GTF2I	molecular association, regulation	transcription, altered	Smad3(INDUCES)		7006	2	5	264		
PITPNM1	Cell surface	O00562	9600	PITPNM1	11q13	human	T59	PHOSPHORYLATION	3597300	PGGSGQYtHKVYHVG	IP_trans	intracellular localization				8195	1	0	0		
B-Myb	DNA binding protein; Motility/polarity/chemotaxis; Transcription factor	P48972	17865	Mybl2		mouse	T497	PHOSPHORYLATION	450109	TPLHRDKtPLHQKYP	Cmyb_C	activity, induced				3936	4	0	4		
Mpl	Membrane protein, integral; Receptor, cytokine	Q08351	17480	Mpl		mouse	S565	PHOSPHORYLATION	3091404	LLEILPKsSESTPLP		activity, induced; phosphorylation	cell growth, altered			8388	1	0	0	tyrosine phosphorylation of JAK2	
AR	DNA binding protein; Nuclear receptor; Transcription factor	P10275	367	AR	Xq12	human	S81	PHOSPHORYLATION	448714	QQQQQETsPRQQQQQ	Androgen_recep	protein stabilization; molecular association, regulation; intracellular localization	cell growth, induced; transcription, altered	CDK5(INDUCES)		8049; 22354422	8	1	0		
Grb10	Adaptor/scaffold	Q60760	14783	Grb10		mouse	S503	PHOSPHORYLATION	455870	MNILSSQsPLHPSTL		protein stabilization				19044701	3	7	9		
MYPT1	Motility/polarity/chemotaxis; Protein phosphatase, regulatory subunit	Q10728	116670	Ppp1r12a		rat	T697	PHOSPHORYLATION	448587	ARQSRRStQGVTLTD		activity, inhibited; phosphorylation				5930036; 8629	49	15	213		
calponin 3	Cytoskeletal protein; Motility/polarity/chemotaxis	Q15417	1266	CNN3	1p22-p21	human	S293	PHOSPHORYLATION	4776192	QGTGTNGsEISDSDY		molecular association, regulation	cytoskeletal reorganization			15562513	2	4	4	stimulates dissociation of calponin 3 from actin cytoskeleton (F-actin)	
gp130	Membrane protein, integral; Receptor, cytokine	P40189	3572	IL6ST	5q11.2	human	Y759	PHOSPHORYLATION	448181	NTSSTVQySTVVHSG		activity, induced; molecular association, regulation; activity, inhibited; phosphorylation	cell differentiation, altered; transcription, altered	SOCS3(INDUCES); SHP-2(INDUCES)		3201; 10292902; 1926906; 4904519; 7309802; 1365; 5929; 4904520	11	1	2		
PEA-15	Apoptosis; Motility/polarity/chemotaxis	Q9Z297	100736554	Pea15		hamster	S104	PHOSPHORYLATION	455750	TKLTRIPsAKKYKDI		molecular association, regulation		ERK1(DISRUPTS); ERK2(DISRUPTS)		5792	7	9	308		
SLCO1A1	Membrane protein, integral; Transporter	P46720	50572	Slco1a1		rat	S635	PHOSPHORYLATION	460720	FPGDIDSsATDHTEM		molecular association, regulation; intracellular localization		PDZK1(INDUCES)		17675048	1	1	0	plasma membrane distribution of SLCO1A1 requires interaction of its unphosphorylated form with PDZK1	
ADRA1B	GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR	P18841		ADRA1B		hamster	S410	PHOSPHORYLATION	451006	DSLDDSGsCMSGSQR		receptor desensitization, altered				3257	1	0	1		
Cx43	Channel, misc.; Membrane protein, integral; Membrane protein, multi-pass; Motility/polarity/chemotaxis	P17302	2697	GJA1	6q22.31	human	S368	PHOSPHORYLATION	447813	QRPSSRAsSRASSRP		activity, inhibited	cell motility, altered			7258; 3346112	17	7	1		
KCNJ2	Channel, potassium; Membrane protein, integral; Membrane protein, multi-pass	P63252	3759	KCNJ2	17q24.3	human	Y242	PHOSPHORYLATION	2097300	RITSEGEyIPLDQID	IRK	activity, inhibited	cell differentiation, altered			1968348	2	0	0	inactivates KCNJ2 current	
ERF	DNA binding protein; Transcription factor	P50548	2077	ERF	19q13	human	S161	PHOSPHORYLATION	456969	SPTEDPRsPPACSSS		intracellular localization	cell cycle regulation			6957	1	3	1		
Cx43	Channel, misc.; Membrane protein, integral; Membrane protein, multi-pass; Motility/polarity/chemotaxis	P17302	2697	GJA1	6q22.31	human	S282	PHOSPHORYLATION	448854	TAPLSPMsPPGYKLV		protein degradation; intracellular localization	cytoskeletal reorganization			7835; 1172869	16	1	1	UV-induced phosphorylation inhibits gap junctional intercellular communication	
TH	Amino Acid Metabolism - tyrosine; EC 1.14.16.2; Endoplasmic reticulum; Mitochondrial; Oxidoreductase; Vesicle protein	P07101	7054	TH	11p15.5	human	S71	PHOSPHORYLATION	448545	RFIGRRQsLIEDARK	TOH_N	enzymatic activity, induced				7484	46	6	11		
sarcolipin	Endoplasmic reticulum; Membrane protein, integral	Q6SLE7		Sln		rat	T5	PHOSPHORYLATION	459214	___MERStQELFINF	Sarcolipin; Phospholamban; SecE	activity, induced				9721223	3	0	0	regulates myocyte calcium transient and contractility	
CRYAB	Chaperone	P23927	12955	Cryab		mouse	S59	PHOSPHORYLATION	448783	PSFLRAPsWIDTGLS	Crystallin	intracellular localization	apoptosis, inhibited; cytoskeletal reorganization			8266; 8337; 6804219	32	14	0		
IRF5	DNA binding protein; Transcription factor	Q13568	3663	IRF5	7q32	human	S437	PHOSPHORYLATION	455994	FSGELSWsADSIRLQ		activity, induced	transcription, induced			25779418; 6568	2	0	0		
CCNB1	Activator protein; Cell cycle regulation	P14635	891	CCNB1	5q12	human	S128	PHOSPHORYLATION	448815	LVDTASPsPMETSGC	Trypan_PARP	intracellular localization			DNA(INDUCES)	25573559; 12778806	5	1	0	enhances nuclear import	
NG2	Cell adhesion; Membrane protein, integral	Q00657	81651	Cspg4		rat	T2256	PHOSPHORYLATION	454952	YLRKRNKtGKHDVQV	DUF3377	intracellular localization	cell motility, altered; cell adhesion, altered			11962; 4377	2	0	0		
NFAT1	DNA binding protein; Transcription factor	Q60591	18019	Nfatc2		mouse	S282	PHOSPHORYLATION	447852	RSPSPQPsPHVALQD			transcription, inhibited			1188	0	1	0		
TNNI3	Actin binding protein; Motility/polarity/chemotaxis; Motor protein	P23693	29248	Tnni3		rat	S24	PHOSPHORYLATION	448424	APVRRRSsANYRAYA	Troponin-I_N	activity, inhibited	cell motility, altered; cytoskeletal reorganization			4313625; 7201; 2703100	33	4	16	heart contractility and relaxation; regulates cardiac contractile function; accelerated relaxation during prolonged activation by endothelin	
14-3-3 beta	Adaptor/scaffold	P35213	56011	Ywhab		rat	S132	PHOSPHORYLATION	3136105	GDYFRYLsEVASGDN	14-3-3	molecular association, regulation		RAF1(DISRUPTS); PKCZ(DISRUPTS)		8741	1	0	0		
Kir6.2	Channel, potassium; Membrane protein, integral; Membrane protein, multi-pass	Q61743	16514	Kcnj11		mouse	T180	PHOSPHORYLATION	450652	QAHRRAEtLIFSKHA	IRK	activity, induced				3116	2	0	0	PKC-mediated activation of ATP-sensitive potassium channels involves phosphorylation of the Kir6.2 subunit at T180.	
CEACAM1	Cell adhesion; Immunoglobulin superfamily; Membrane protein, integral; Motility/polarity/chemotaxis	P13688	634	CEACAM1	19q13.2	human	S494	PHOSPHORYLATION	473039	KMNEVTYsTLNFEAQ	DUF2668		apoptosis, altered; cytoskeletal reorganization			9160	1	0	0	plays a role in cell polarization and lumen formation	
MYST2	ACETYLTRANSFERASE; Acetyltransferase; EC 2.3.1.48; Nuclear receptor co-regulator; Transcription, coactivator/corepressor	O95251	11143	KAT7	17q21.32	human	T88	PHOSPHORYLATION	468239	QQQPTPVtPKKYPLR			cell growth, induced			28722433	2	17	40	increase in mammosphere formation	
KHSRP	RNA binding protein	Q92945	8570	KHSRP	19p13.3	human	S193	PHOSPHORYLATION	473552	GLPERSVsLTGAPES	KH_1	molecular association, regulation; intracellular localization; protein conformation	transcription, altered	14-3-3 sigma(INDUCES); 14-3-3 zeta(INDUCES)		9175; 7326900	2	1	6	controls beta-catenin gene expression by controlling its mRNA stability;  phosphorylation of this site inhibits interaction with the exosome	
ARHGEF7 iso1	Guanine nucleotide exchange factor, Rac/Rho; Motility/polarity/chemotaxis	Q14155-1	8874	ARHGEF7	13q34	human	T526	PHOSPHORYLATION	455216	EFASRKStAALEEDA		activity, induced	cytoskeletal reorganization			7991129	6	4	1	S525/T526 phosphorylation regulates Rac1 activation and growth cone extension/retraction.	
DDR2	EC 2.7.1.112; EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Protein kinase, TK; Protein kinase, tyrosine (receptor)	Q16832	4921	DDR2	1q23.3	human	Y471	PHOSPHORYLATION	451276	EQGSNSTyDRIFPLR	Shisa; Herpes_gE	molecular association, regulation		Shc1(INDUCES)		3499	1	1	12		
FOXM1	DNA binding protein; Transcription factor	Q08050	2305	FOXM1	12p13	human	T600	PHOSPHORYLATION	478080	EVGGPFKtPIKETLP		protein stabilization	transcription, induced			22495316	2	1	2		
Rad17	Cell cycle regulation	O75943	5884	RAD17	5q13	human	S656	PHOSPHORYLATION	447756	SASELPAsQPQPFSA		molecular association, regulation; phosphorylation	cell cycle regulation; cell growth, altered	RAD1(INDUCES); claspin(INDUCES)		6453; 818; 2480200	8	0	0	regulates genomic stability, phosphorylation of Chk1	
NEK2	EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor)	P51955	4751	NEK2	1q32.2-q41	human	T179	PHOSPHORYLATION	12574601	FAKTFVGtPYYMSPE	Pkinase	enzymatic activity, inhibited				12482404	1	2	0		
NFkB-p105	DNA binding protein; Transcription factor	P19838	4790	NFKB1	4q24	human	S893	PHOSPHORYLATION	451564	EVIQAASsPVKTTSQ		activity, induced; protein processing				3704	2	3	6	Mutation of this site retards the proteolytic processing of p105 that generates active NFkB. 	
PDK1	EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor)	O15530	5170	PDPK1	16p13.3	human	T513	PHOSPHORYLATION	450132	PEAKNFKtFFVHTPN		molecular association, regulation; enzymatic activity, induced		PDK1(DISRUPTS)		15785206	5	3	0		
PLD1 iso2	EC 3.1.4.4; Lipid Metabolism - ether lipid; Lipid Metabolism - glycerophospholipid; Motility/polarity/chemotaxis; Phospholipase	P70496-2	25096	Pld1		rat	T147	PHOSPHORYLATION	448573	PIPTKRHtFRRQNVK	PX	enzymatic activity, induced				1392; 1391	5	0	0		
Hck	EC 2.7.10.2; KINASE; Kinase, protein; Protein kinase, TK; Protein kinase, tyrosine (non-receptor)	P08103	15162	Hck		mouse	Y50	PHOSPHORYLATION	448169	ANQKGPVyVPDPTSS		enzymatic activity, induced				1653	1	2	72		
PZR	Adaptor/scaffold; Membrane protein, integral	O95297	9019	MPZL1	1q24.2	human	Y241	PHOSPHORYLATION	451272	SHQGPVIyAQLDHSG	Myelin-PO_C	molecular association, regulation	cell adhesion, altered	SHP-2(INDUCES)		3491	1	11	419		
EphB1	EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Protein kinase, TK; Protein kinase, tyrosine (receptor)	P54762	2047	EPHB1	3q21-q23	human	Y594	PHOSPHORYLATION	449995	GSPGMKIyIDPFTYE		molecular association, regulation; phosphorylation	cell motility, altered; cell adhesion, altered	Nck1(INDUCES)		3683; 2545; 8537	4	13	115	phosphorylation of Grb7; JNK1 activation; Stimulation of EphB1 and EphB2 induced a complex between Nik/Nck1, Dok1, RasGAP, and an unidentified 145-kDa tyrosine-phosphorylated protein.	
PEDF	Inhibitor protein; Secreted; Secreted, signal peptide	P36955	5176	SERPINF1	17p13.3	human	S24	PHOSPHORYLATION	455231	SSCQNPAsPPEEGSP		molecular association, regulation	apoptosis, altered; carcinogenesis, altered; cell motility, altered	LEPR(INDUCES)		18410809	2	0	0		
Snail1	C2H2-type zinc finger protein; Transcription factor	O95863	6615	SNAI1	20q13.2	human	S115	PHOSPHORYLATION	6097707	PAPSSFSsTSVSSLE	CAP_N	intracellular localization	cell motility, altered; transcription, altered			6066701; 6098000	2	0	0	Localization mediated by S107, S111, S115 and S119. 	
IRS1	Adaptor/scaffold; Motility/polarity/chemotaxis	P35568	3667	IRS1	2q36	human	S312	PHOSPHORYLATION	447558	TESITATsPASMVGG		protein degradation; molecular association, regulation; intracellular localization	apoptosis, altered	IKKB(DISRUPTS); IKKA(DISRUPTS)		6115915; 5861; 5616; 8915	62	5	0		
iNOS	Amino Acid Metabolism - arginine and proline; EC 1.14.13.39; Oxidoreductase	P35228	4843	NOS2	17q11.2-q12	human	S745	PHOSPHORYLATION	763800	KSRQNLQsPTSSRAT	FAD_binding_1	enzymatic activity, induced				762716	1	1	0		
TXN		P10599	7295	TXN	9q31	human	T100	PHOSPHORYLATION	457590	NKEKLEAtINELV__	Thioredoxin	intracellular localization	apoptosis, altered			15026102	1	1	0		
ASIC3	Channel, cation; Membrane protein, integral; Membrane protein, multi-pass	O35240	286920	Accn3		rat	S523	PHOSPHORYLATION	12518703	VTKTLSAsHRTCYLV		activity, induced				12482279	1	0	0	channel activation	
LHX3	DNA binding protein; Transcription factor	Q9UBR4	8022	LHX3	9q34.3	human	S71	PHOSPHORYLATION	455295	PLAERCFsRGESVYC	LIM	activity, induced	transcription, induced			4438	1	0	0	no change in binding to DNA or to certain proteins (NLI, PIT1, or MRG1)	
SCN1B	Channel, sodium; Membrane protein, integral	Q00954	29686	Scn1b		rat	Y200	PHOSPHORYLATION	455547	AQENASEyLAITSES	7TM_GPCR_Srw	molecular association, regulation		ANK1(DISRUPTS)		5433	1	0	0		
AT1	GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR	P30556	185	AGTR1	3q24	human	Y319	PHOSPHORYLATION	448745	YFLQLLKyIPPKAKS		molecular association, regulation		PLCG1(INDUCES)		2725	5	0	0		
JIP1	Adaptor/scaffold	Q9UQF2	9479	MAPK8IP1	11p11.2	human	T103	PHOSPHORYLATION	449924	LIDATGDtPGAEDDE		molecular association, regulation		DLK(DISRUPTS)		2468	2	1	1		
MST2	Autophagy; EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, STE; Protein kinase, Ser/Thr (non-receptor)	O54748	65189	Stk3		rat	T180	PHOSPHORYLATION	448899	DTMAKRNtVIGTPFW	Pkinase	enzymatic activity, induced				2554	7	0	5		
PTGIR	GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR	P43252	19222	Ptgir		mouse	S355	PHOSPHORYLATION	450985	APLSRPAsGRRDPPA		molecular association, regulation		G-alpha2(i)(INDUCES); G-alpha(q)(INDUCES)		6316	3	0	0		
Oct1	DNA binding protein; Transcription factor	P14859	5451	POU2F1	1q24.2	human	S385	PHOSPHORYLATION	456220	RRRKKRTsIETNIRV	Homeobox	molecular association, regulation; activity, inhibited			DNA(DISRUPTS)	6669	1	5	0		
CD44	Cell adhesion; Membrane protein, integral; Motility/polarity/chemotaxis; Receptor, misc.	P16070	960	CD44	11p13	human	S704	PHOSPHORYLATION	465561	SGLNGEAsKSQEMVH	Bravo_FIGEY	molecular association, regulation; intracellular localization	cell motility, altered	MMP9(DISRUPTS)		9721221; 8050	3	5	8		
VHL	Tumor suppressor; UBIQUITIN LIGASE; Ubiquitin ligase	P40337	7428	VHL	3p25.3	human	S68	PHOSPHORYLATION	469116	PVLRSVNsREPSQVI	VHL	molecular association, regulation	cytoskeletal reorganization	HIF2A(DISRUPTS)		8267	2	0	0	destabilizes microtubules	
ANTXR2	Membrane protein, integral; Receptor, misc.	P58335	118429	ANTXR2	4q21.21	human	Y463	PHOSPHORYLATION	13320000	WALLRRQyDRVSLMR	Ant_C	ubiquitination				13270511	1	0	0		
PDGFRB	EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Protein kinase, TK; Protein kinase, tyrosine (receptor)	P05622	18596	Pdgfrb		mouse	Y1008	PHOSPHORYLATION	447522	LDTSSVLyTAVQPNE		molecular association, regulation; phosphorylation		SHP-2(INDUCES)		2587200; 1690	16	0	0		
STAT1	DNA binding protein; Transcription factor	P42224	6772	STAT1	2q32.2	human	K703	SUMOYLATION	3278913	PKGTGYIkTELISVS		phosphorylation				3146308	6	1	0	inhibits phosphorylation of Y701	
Shc3	Adaptor/scaffold; Motility/polarity/chemotaxis	Q92529	53358	SHC3	9q22.1	human	Y424	PHOSPHORYLATION	451259	PTGEAPTyVNTQQIP			apoptosis, inhibited			6002	3	0	1		
NEDD1	Cell cycle regulation	Q8NHV4	121441	NEDD1	12q23.1	human	T550	PHOSPHORYLATION	6225645	PPINGSStPNPKIAS		molecular association, regulation; phosphorylation	cell cycle regulation	PLK1(INDUCES)		9201031	2	1	6	important for binding of NEDD1 with gamma-tubulin; facilitates phosphorylation of NEDD1 T382, S397, S426, S637 by Plk1 in vitro	
PLD2	EC 3.1.4.4; Lipid Metabolism - ether lipid; Lipid Metabolism - glycerophospholipid; Motility/polarity/chemotaxis; Phospholipase	O14939	5338	PLD2	17p13.1	human	Y169	PHOSPHORYLATION	458806	KQKYLENyLNRLLTM	PX	molecular association, regulation; enzymatic activity, induced	cell motility, altered; cell growth, altered	Grb2(INDUCES)		7467; 15022725	2	0	0		
eIF6	Translation; Translation initiation	P56537	3692	EIF6	20q12	human	S174	PHOSPHORYLATION	17535702	IEDQDELsSLLQVPL	eIF-6	intracellular localization				17431524	1	0	0	required for the nuclear export of eIF6	
IRS1	Adaptor/scaffold; Motility/polarity/chemotaxis	P35570	25467	Irs1		rat	S336	PHOSPHORYLATION	455324	GTMSRPAsVDGSPVS		phosphorylation				4591	2	0	7	primes S332 for phosphorylation by GSK3B; decreases tyrosine phosphorylation of IRS-1 and Akt1 phosphorylation upon insulin stimulation	
IFNGR1	Membrane protein, integral; Receptor, cytokine	P15260	3459	IFNGR1	6q23.3	human	Y457	PHOSPHORYLATION	451253	KAPTSFGyDKPHVLV		molecular association, regulation	cell cycle regulation; transcription, altered	STAT1(INDUCES)		3467; 8566	4	2	22	Induced with serum and IFN-gamma 	
ANPB	EC 4.6.1.2; Guanylyl cyclase; KINASE; Kinase, protein; Lyase; Membrane protein, integral; Nucleotide Metabolism - purine; Protein kinase, RGC; Protein kinase, dual-specificity; Receptor, misc.	P16067	116564	Npr2		rat	S526	PHOSPHORYLATION	450024	LRGSSYGsLMTAHGK	Pkinase_Tyr	activity, induced				2568	2	3	0		
NKX3-1	DNA binding protein; Transcription factor	Q99801	4824	NKX3-1	8p21.2	human	T89	PHOSPHORYLATION	464287	AAPEEAEtLAETEPE	Trypan_PARP	protein stabilization				7864	2	0	0		
DBI	Lipid binding protein	Q8WN94	100008823	DBI		rabbit	T36	PHOSPHORYLATION	2833501	YSHYKQAtVGDVNTE	ACBP	molecular association, regulation		GABRA1(INDUCES)		2831770	1	1	0		
HSP27	Chaperone; Motility/polarity/chemotaxis	P15991		HSPB1		hamster	S15	PHOSPHORYLATION	448401	FSLLRSPsWEPFRDW		activity, induced; molecular association, regulation	apoptosis, altered	IKKA(INDUCES)		2531306; 4676; 7036	33	40	27		
AA-NAT	ACETYLTRANSFERASE; Acetyltransferase; Amino Acid Metabolism - tryptophan; EC 2.3.1.87	Q29495	443531	AANAT		sheep	T31	PHOSPHORYLATION	452141	PGRQRRHtLPANEFR		molecular association, regulation; enzymatic activity, induced		14-3-3 zeta(INDUCES)		8210; 4651306	3	0	0		
SLP76	Adaptor/scaffold	Q60787	16822	Lcp2		mouse	S376	PHOSPHORYLATION	476784	IGFQQSAsLPPYFSQ		protein degradation; ubiquitination				25712655	3	0	0		
NOLC1	Transcription, coactivator/corepressor	P41777	64896	Nolc1		rat	S627	PHOSPHORYLATION	455685	KKGEKRAsSPFRRVR		activity, induced	transcription, altered			6382	1	10	3		
APP iso4	Apoptosis; Cell surface; Membrane protein, integral; Receptor, misc.; Transcription factor	P05067-4	351	APP	21q21.3	human	Y687	PHOSPHORYLATION	450343	NGYENPTyKFFEQMQ	APP_amyloid	protein stabilization; protein processing; intracellular localization				2858605; 2884007	4	6	238		
NPM1	RNA binding protein; Translation	P06748	4869	NPM1	5q35.1	human	T219	PHOSPHORYLATION	449023	KDSKPSStPRSKGQE	Nop14; TFIIF_alpha	molecular association, regulation			RNA(DISRUPTS)	2056	1	11	17		
hnRNP D0	RNA binding protein; RNA splicing	Q14103	3184	HNRNPD	4q21	human	S87	PHOSPHORYLATION	449337	SNSSPRHsEAATAQR			transcription, induced; RNA stability, altered		RNA(INDUCES)	3001; 8555	3	5	0		
RGS10	GTPase activating protein, RGS	O43665	6001	RGS10	10q25	human	S168	PHOSPHORYLATION	455907	QTAAKRAsRIYNT__		intracellular localization				6420	2	1	4		
NFkB-p65	DNA binding protein; Nuclear receptor co-regulator; Transcription factor	Q04207	19697	Rela		mouse	S534	PHOSPHORYLATION	447800	SGDEDFSsIADMDFS		activity, induced; protein degradation; molecular association, regulation; protein processing	carcinogenesis, induced; transcription, induced; transcription, altered	p300(INDUCES); p90RSK(INDUCES)		15658701; 2621803; 6943; 12735103; 6907; 3475701	103	0	0		
PhLP	G protein regulator, misc.	Q13371	5082	PDCL	9q12-q13	human	S20	PHOSPHORYLATION	448825	LQYYYSSsEDEDSDH		molecular association, regulation		G-gamma(2)(INDUCES); CCT-alpha(INDUCES)		7972; 5798	3	4	3	facilitates dimerization of subunits beta and gamma of G-protein 
; PhLP phosphorylation at S18-S20 induces association of G-gamma(2) with a G-beta(1)/PhLP complex.  These PhLP phosphorylations are also required for normal G-beta/G-gamma dimer assembly.	
KLC1	Microtubule binding protein; Motor protein	O88447	16593	Klc1		mouse	S459	PHOSPHORYLATION	477826	YKACKVDsPTVTTTL		molecular association, regulation		CLSTN1(DISRUPTS)		18711402	1	19	3		
SCN8A	Channel, sodium; Membrane protein, integral; Membrane protein, multi-pass	Q9WTU3	20273	Scn8a		mouse	Y1945	PHOSPHORYLATION	14828400	STASLPSyDSVTKPD		molecular association, regulation; activity, inhibited		NEDD4L(INDUCES)		14743115	1	0	0		
FLEG1	Histone-binding protein	Q8NCD3	55355	HJURP	2q37.1	human	S486	PHOSPHORYLATION	482923	GLETRRLsLPSSKAK		molecular association, regulation		14-3-3 gamma(INDUCES)		11769	1	7	3		
IMP-1	Translation	Q8CGX0	303477	Igf2bp1		rat	Y396	PHOSPHORYLATION	458348	SVTGAAPyGSFMQAP			translation, altered			15026108	3	0	0		
Abl	EC 2.7.1.112; EC 2.7.10.2; KINASE; Kinase, protein; Protein kinase, TK; Protein kinase, tyrosine (non-receptor)	P00520	11350	Abl1		mouse	T547	PHOSPHORYLATION	450294	EQKDAPDtPELLHTK		enzymatic activity, induced	cytoskeletal reorganization			4437	2	0	0		
HSP90A	Chaperone	P07900	3320	HSP90AA1	14q32.33	human	T90	PHOSPHORYLATION	476047	NKQDRTLtIVDTGIG	HATPase_c	molecular association, regulation	exocytosis, altered; cell growth, altered	Cdc37(DISRUPTS); HSP70(DISRUPTS); CHIP(INDUCES); PKCG(DISRUPTS); STI1(DISRUPTS); Src(DISRUPTS); PPP5C(INDUCES); TEBP(INDUCES); AHSA1(INDUCES); Akt1(DISRUPTS)		11999218; 22689015	2	1	0	HSP90 secretion leading to proinvasiveness; T90 phosphorylation regulates the HSP90A co-chaperone machinery and binding affinity with client proteins.	
IREB1	Carbohydrate Metabolism - citrate (TCA) cycle; Carbohydrate Metabolism - glyoxylate and dicarboxylate; EC 4.2.1.3; Endoplasmic reticulum; Lyase; RNA binding protein; Translation	P21399	48	ACO1	9p21.1	human	S138	PHOSPHORYLATION	451387	DFNRRADsLQKNQDL	Aconitase	protein degradation; molecular association, regulation; enzymatic activity, inhibited			RNA(INDUCES)	7794; 7613724; 7434	5	0	0		
SRR	Amino Acid Metabolism - glycine, serine and threonine; EC 4.3.1.17; EC 4.3.1.18; EC 5.1.1.18; Isomerase	Q76EQ0		Srr		rat	T227	PHOSPHORYLATION	7594900	SKLKGELtPNLHPPE	PALP	intracellular localization				7543521	2	2	0	regulates membrane-binding of Srr	
AhR	DNA binding protein; Nuclear receptor; Transcription factor	P35869	196	AHR	7p15	human	S36	PHOSPHORYLATION	451413	EGIKSNPsKRHRDRL	HLH	intracellular localization	transcription, altered			3610	1	0	0	Dephosphorylated AhR enters the nucleus.  	
CCDC50 iso2	Inhibitor protein	Q8IVM0	152137	CCDC50	3q28	human	Y217	PHOSPHORYLATION	6377637	MAEEKKAyKKAKERE	DUF1462; CCDC50_N	phosphorylation	apoptosis, inhibited; cell growth, altered			6376200	1	0	0	 ;  inhibits NF-kB activity; inhibits phosphorylation of IKKbeta through TNFalpha	
STEP	EC 3.1.3.48; Membrane protein, multi-pass; Motility/polarity/chemotaxis; PHOSPHATASE; Protein phosphatase, tyrosine (non-receptor)	P35234	29644	Ptpn5		rat	S49	PHOSPHORYLATION	448294	GLQERRGsNVSLTLD		ubiquitination; enzymatic activity, inhibited				14654315	5	0	0		
PTP-PEST	EC 3.1.3.48; Motility/polarity/chemotaxis; PHOSPHATASE; Protein phosphatase, tyrosine (non-receptor)	NP_035333	19248	Ptpn12		mouse	S39	PHOSPHORYLATION	451311	FMRLRRLsTKYRTEK		enzymatic activity, inhibited				11424217	3	0	15		
PDHK1	EC 2.7.11.2; KINASE; Kinase, protein; Mitochondrial; Protein kinase, ATYPICAL; Protein kinase, atypical	Q8BFP9	228026	Pdk1		mouse	Y241	PHOSPHORYLATION	462384	ARRLCDLyYVNSPEL			cell growth, induced			25220606	1	0	2	Y to F mutants show decreased proliferation under hypoxia and increased oxidative phosphorylation. 	
ADCY2	Adenylyl cyclase; EC 4.6.1.1; Lyase; Membrane protein, integral; Membrane protein, multi-pass; Nucleotide Metabolism - purine	P26769	81636	Adcy2		rat	T1057	PHOSPHORYLATION	451157	QTLGYTCtCRGIINV	Guanylate_cyc	activity, induced				3326	2	0	0		
Net1	Guanine nucleotide exchange factor, Rac/Rho; Motility/polarity/chemotaxis	Q9Z206	56349	Net1		mouse	S152	PHOSPHORYLATION	455600	PTPTKRRsSALWSEM		activity, inhibited	cytoskeletal reorganization			5530	1	0	0	inhibits guanine nucleotide exhange activity toward RhoA, inhibits actin stress fiber formation	
Cx43	Channel, misc.; Membrane protein, integral; Membrane protein, multi-pass; Motility/polarity/chemotaxis	P08050	24392	Gja1		rat	S373	PHOSPHORYLATION	459209	RASSRASsRPRPDDL		activity, induced; molecular association, regulation		14-3-3 theta(INDUCES); 14-3-3 zeta(INDUCES)		8412; 2875301; 9009	8	4	0		
Mer	EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Protein kinase, TK; Protein kinase, tyrosine (receptor)	Q12866	10461	MERTK	2q14.1	human	Y754	PHOSPHORYLATION	449990	KIYSGDYyRQGRIAK	Pkinase_Tyr	enzymatic activity, induced				2539	1	5	67		
GFAT2	Amino Acid Metabolism - alanine, aspartate and glutamate; Carbohydrate Metabolism - amino sugar and nucleotide sugar; EC 2.6.1.16; Transferase	Q9Z2Z9	14584	Gfpt2		mouse	S202	PHOSPHORYLATION	451674	AVATRRGsPLLIGVR	GATase_2	enzymatic activity, induced				3779	1	1	0		
PSEN2	Cell surface; EC 3.4.23.-; Membrane protein, integral; Membrane protein, multi-pass; Protease	P49810	5664	PSEN2	1q31-q42	human	S327	PHOSPHORYLATION	448564	DPEMEEDsYDSFGEP	Presenilin	protein stabilization	apoptosis, inhibited			1250	2	0	0	Phosphorylation of Presenilin 2 inhibits its cleavage by caspase-3.	
Cdc25A	EC 3.1.3.48; Motility/polarity/chemotaxis; PHOSPHATASE; Protein phosphatase, dual-specificity	P30304	993	CDC25A	3p21	human	S513	PHOSPHORYLATION	26342100	RTWAGEKsKREMYSR		protein degradation	cell cycle regulation			25789406	1	1	0	proteasome mediated degradation	
FOXO4	DNA binding protein; Transcription factor	P98177	4303	FOXO4	Xq13.1	human	T455	PHOSPHORYLATION	448570	ALGTPVLtPPTEAAS		intracellular localization	cell cycle regulation; transcription, induced			4299; 911	3	2	0		
GRASP65	Vesicle protein	O35254	56082	Gorasp1		rat	S277	PHOSPHORYLATION	455582	EQLPGPGsPGHGTAD		activity, induced; molecular association, regulation	cell cycle regulation; cytoskeletal reorganization			4651311; 5525	3	0	0	Golgi cisternae unstacking and orientation during motility	
ASK1	EC 2.7.11.25; KINASE; Kinase, protein; Protein kinase, STE; Protein kinase, Ser/Thr (non-receptor)	Q99683	4217	MAP3K5	6q22.33	human	T813	PHOSPHORYLATION	990312	GDNVLINtYSGVLKI	Pkinase		transcription, altered			970044	1	0	0		
TTK	Cancer Testis Antigen (CTA); EC 2.7.12.1; KINASE; Kinase, protein; Protein kinase, Other; Protein kinase, dual-specificity	P33981	7272	TTK	6q13-q21	human	Y811	PHOSPHORYLATION	459314	GTTEEMKyVLGQLVG		protein stabilization; enzymatic activity, induced				4042509	1	1	6		
FMIP	Cell development/differentiation; RNA splicing; Spliceosome	Q13769	8563	THOC5	22q12.2	human	S5	PHOSPHORYLATION	453432	___MSSEsSKKRKPK		intracellular localization				4145	1	0	0		
PLK2	EC 2.7.11.21; KINASE; Kinase, protein; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor)	P53351	20620	Plk2		mouse	T236	PHOSPHORYLATION	25790901	PLEHRRRtICGTPNY	Pkinase	enzymatic activity, induced	cytoskeletal reorganization			25785402	2	0	0	The T236E constitutively active mutant, showed arborization and rounding.   	
RAF1	EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, Ser/Thr (non-receptor); Protein kinase, TKL	P04049	5894	RAF1	3p25	human	S338	PHOSPHORYLATION	447742	RPRGQRDsSYYWEIE		molecular association, regulation; intracellular localization; protein conformation; enzymatic activity, induced	cell cycle regulation; carcinogenesis, induced	Bcl-2(INDUCES); MEK1(INDUCES); PLK1(INDUCES); 14-3-3 beta(DISRUPTS)		772; 2512; 7543532; 5692; 6528; 6052; 5121526; 6385; 7156; 5121520; 6115934; 7839; 8397; 5121525; 6072; 1253; 5121524; 25027304; 12068402; 6811	73	2	6		
STMN1	Cytoskeletal protein	P13668	29332	Stmn1		rat	S16	PHOSPHORYLATION	448554	KELEKRAsGQAFELI	Stathmin		cytoskeletal reorganization	TUBA1B(DISRUPTS); TUBB(DISRUPTS)		8227	23	46	53	Stathmin is a microtubule destabilizing protein. Its phosphorylation relieves the inhibition of microtubule polymerization.	
SREBP-1 iso4	DNA binding protein; Membrane protein, integral; Membrane protein, multi-pass; Transcription factor	Q9WTN3-4	20787	Srebf1		mouse	S265	PHOSPHORYLATION	7996200	AIEKRYRsSINDKIV	HLH	molecular association, regulation	transcription, altered		DNA(DISRUPTS)	7889908	1	0	0	regulates hepatic lipogenesis	
Tiam1	Guanine nucleotide exchange factor, Rac/Rho; Motility/polarity/chemotaxis	Q60610	21844	Tiam1		mouse	Y384	PHOSPHORYLATION	7362700	DRARQGVyENFRREL		protein degradation; molecular association, regulation	cell motility, altered; cytoskeletal reorganization	ERK2(INDUCES); ERK1(INDUCES); Grb2(INDUCES)		7303918	1	1	7	Grb2-Sos1 	
TRIM32	EC 6.3.2.-; EC 6.3.2.19; Ligase; UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase	Q13049	22954	TRIM32	9q33.1	human	S651	PHOSPHORYLATION	27717300	SYHLRRYsTP_____		molecular association, regulation; ubiquitination; intracellular localization; protein conformation	cell growth, induced	14-3-3 eta(INDUCES)		27619350	1	0	0	14-3-3 binding prevents both TRIM32 autoubiquitylation and TRIM32 transubiquitylation	
Ron	EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Protein kinase, TK; Protein kinase, tyrosine (receptor)	Q62190	19882	Mst1r		mouse	Y1330	PHOSPHORYLATION	456487	ASLLGDHyVQLTAAY		enzymatic activity, induced	apoptosis, induced; cell growth, altered	Shc1(INDUCES); PLCG1(INDUCES); PIK3CA(INDUCES); Grb2(INDUCES)		6746; 6720	3	0	0		
FOXC1	Cell cycle regulation; Cell development/differentiation; DNA binding protein; Transcription factor	Q12948	2296	FOXC1	6p25	human	S272	PHOSPHORYLATION	460580	SSLSSGSsPPGSLPS		activity, induced; protein stabilization	transcription, induced			7711	1	1	0	activation of ERK1/2 is required for FOXC1 activation and stability 	
SPTBN1	Cytoskeletal protein; Motility/polarity/chemotaxis	Q01082	6711	SPTBN1	2p21	human	T2159	PHOSPHORYLATION	471399	NGATEQRtSSKESSP		molecular association, regulation		SPTAN1(DISRUPTS)		9088	1	13	1	increases in PC12 cells during neurite formation	
VEGFR1	EC 2.7.1.112; EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Protein kinase, TK; Protein kinase, tyrosine (receptor)	P17948	2321	FLT1	13q12	human	Y794	PHOSPHORYLATION	455807	SSEIKTDyLSIIMDP	DUF4083	phosphorylation	cell cycle regulation; cell differentiation, altered			2506305; 6230	2	0	1	angiogenesis	
STXBP5	Vesicle protein	Q9WU70	81022	Stxbp5		rat	S724	PHOSPHORYLATION	459032	GSSSPHNsDDEQKVN		molecular association, regulation	exocytosis, altered	STX1B(DISRUPTS)		7588	1	2	0		
UBE2J1	EC 6.3.2.19; Ligase; Membrane protein, integral; UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase	Q9Y385	51465	UBE2J1	6q15	human	S184	PHOSPHORYLATION	465537	KELARQIsFKAEVNS	ATPase-cat_bd	enzymatic activity, induced				7981	2	3	51		
Fyn	EC 2.7.10.2; KINASE; Kinase, protein; Protein kinase, TK; Protein kinase, tyrosine (non-receptor)	P06241	2534	FYN	6q21	human	Y531	PHOSPHORYLATION	447883	FTATEPQyQPGENL_		intracellular localization; enzymatic activity, inhibited; phosphorylation	cell growth, altered			7110; 2364; 1099	15	10	1039	Localization of Fyn is modulated by PDEF in cells expressing wild-FES (WT6-8 cells) , but not in cells with inactive FES (KE5-15).  	
MKK3	EC 2.7.12.2; KINASE; Kinase, protein; Protein kinase, STE; Protein kinase, dual-specificity	P46734	5606	MAP2K3	17q11.2	human	T222	PHOSPHORYLATION	448277	LVDSVAKtMDAGCKP	Pkinase	activity, induced; enzymatic activity, induced	cell cycle regulation; transcription, induced			2852638; 715; 1173013	4	1	2		
ZO1	Adaptor/scaffold; Motility/polarity/chemotaxis	P39447	21872	Tjp1		mouse	Y1177	PHOSPHORYLATION	450402	YRPEAQPySSTGPKS			cell cycle regulation; cell motility, altered			2790302	0	4	36		
Ku70	DNA binding protein; DNA repair; EC 3.6.4.-; EC 4.2.99.-; Helicase	P23475	14375	Xrcc6		mouse	S6	PHOSPHORYLATION	452070	__MSEWEsYYKTEGE		molecular association, regulation		Bax(DISRUPTS)		9985907	3	2	0	kainate treatment increases interaction of Ku70 with Bax	
Siva	Apoptosis	O15304	10572	SIVA1	14q32.33	human	Y34	PHOSPHORYLATION	448080	RGVCAERySQEVFEK	Siva		apoptosis, induced			1604	1	0	0		
NDFIP2	Adaptor/scaffold; Membrane protein, integral; Membrane protein, multi-pass	Q9NV92	54602	NDFIP2	13q31.1	human	Y171	PHOSPHORYLATION	15229530	TEVYGEFyPVPPPYS	DUF2370	molecular association, regulation		Lyn(INDUCES)		25779412	1	0	1		
RSK2	EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor)	P18654	110651	Rps6ka3		mouse	S386	PHOSPHORYLATION	448065	HQLFRGFsFVAITSD	Pkinase_C	molecular association, regulation; phosphorylation; enzymatic activity, induced		PDK1(INDUCES)		1263; 2852652	8	11	47		
FOXM1	DNA binding protein; Transcription factor	Q08050	2305	FOXM1	12p13	human	T620	PHOSPHORYLATION	3194573	SKSVLPRtPESWRLT		protein stabilization	transcription, induced			22495316	2	2	14		
RHBG iso6	Membrane protein, integral; Membrane protein, multi-pass; Transporter	F8W6Q8	57127	RHBG	1q21.3	human	Y428	PHOSPHORYLATION	3647000	DPPDSQHyEDQVHWQ		intracellular localization; activity, inhibited				3301207	1	0	0		
NFE2L1	DNA binding protein; Transcription factor	Q14494	4779	NFE2L1	17q21.3	human	S379	PHOSPHORYLATION	27971902	SQDFLLFsPEVESLP		protein degradation; ubiquitination	apoptosis, induced			27902306	1	0	0		
Borealin	Cell cycle regulation	Q53HL2	55143	CDCA8	1p34.3	human	S275	PHOSPHORYLATION	482836	RLAQICSsIRTHK__	Borealin; F-box		cell growth, altered			11759	1	1	0		
FLT3	EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Protein kinase, TK; Protein kinase, tyrosine (receptor)	P36888	2322	FLT3	13q12	human	Y768	PHOSPHORYLATION	459389	HSEDEIEyENQKRLE	Pkinase_Tyr	molecular association, regulation	cell cycle regulation	Grb2(INDUCES)		7910519	2	0	0	regulates cell proliferation	
PKD1	Autophagy; EC 2.7.11.13; KINASE; Kinase, protein; Motility/polarity/chemotaxis; Protein kinase, CAMK; Protein kinase, Ser/Thr (non-receptor)	Q15139	5587	PRKD1	14q11	human	Y463	PHOSPHORYLATION	448648	NDTGSRYyKEIPLSE	PH	protein conformation; phosphorylation; enzymatic activity, induced	cell differentiation, altered; apoptosis, inhibited; transcription, altered; cell growth, altered			1844; 3615; 2091; 2512009; 762717	7	0	0	angiogenesis; leads to PLC-gamma phosphorylation; activates transciption; Y463 phosphorylation activates PKD and induces NF-kB and IKKB activation and degredation. 	
4E-BP1	Translation; Translation initiation	Q62622	116636	Eif4ebp1		rat	S82	PHOSPHORYLATION	447525	PTIPGVTsPTSDEPP	eIF_4EBP	molecular association, regulation	translation, altered	eIF4E(DISRUPTS)		842	4	7	0		
MOR-1	GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR	P33535	25601	Oprm1		rat	Y106	PHOSPHORYLATION	455804	MKTATNIyIFNLALA	7tm_1; TM	activity, inhibited				6183	2	0	0		
TAGLN	Actin binding protein; Motility/polarity/chemotaxis	Q01995	6876	TAGLN	11q23.2	human	S181	PHOSPHORYLATION	469978	VIGLQMGsNRGASQA	Calponin	molecular association, regulation	cytoskeletal reorganization	ACTB(DISRUPTS)		8816; 9098	3	6	14		
H3	DNA binding protein	P68431	8350	HIST1H3A	6p22.1	human	T46	PHOSPHORYLATION	455679	PHRYRPGtVALREIR		molecular association, regulation	apoptosis, induced; transcription, altered		DNA(INDUCES)	25185212; 7543501	2	4	3	repression of E-cadherin expression, upregulation of fibronectin expression 	
RARA	DNA binding protein; Nuclear receptor; Transcription factor	P10276	5914	RARA	17q21	human	S445	PHOSPHORYLATION	455329	APPPGSCsPSLSPSS		protein degradation; ubiquitination				4599	3	1	0		
TAK1	EC 2.7.11.25; KINASE; Kinase, protein; Protein kinase, Ser/Thr (non-receptor); Protein kinase, TKL	O43318	6885	MAP3K7	6q15	human	T178	PHOSPHORYLATION	3303400	LKICDFGtACDIQTH	Pkinase_Tyr	phosphorylation; enzymatic activity, induced				3301224; 14780521	2	0	0	facilitates autophosphorylation of T184 and T187	
NPM1	RNA binding protein; Translation	P06748	4869	NPM1	5q35.1	human	T237	PHOSPHORYLATION	449560	KQEKTPKtPKGPSSV	Nop14; TFIIF_alpha	molecular association, regulation; intracellular localization	cell cycle regulation		RNA(DISRUPTS)	2056; 5607	4	11	17		
Btk	EC 2.7.10.2; KINASE; Kinase, protein; Protein kinase, TK; Protein kinase, tyrosine (non-receptor)	P35991	12229	Btk		mouse	S115	PHOSPHORYLATION	463807	EGPLYVFsPTEELRK	PH	molecular association, regulation		Pin1(INDUCES)		7851	1	0	0	Interaction with Pin1 negatively regulates Btk expression.	
PPP1R1C	Motility/polarity/chemotaxis; Protein phosphatase, regulatory subunit	Q8WVI7	151242	PPP1R1C	2q31.3	human	T34	PHOSPHORYLATION	2807902	QIRKRRPtPASLVIL	DARPP-32	activity, induced	cell cycle regulation; cell growth, altered			2807203	1	0	0	activates inhibition of PP1, and increases cell growth	
PKCD	EC 2.7.10.2; EC 2.7.11.13; KINASE; Kinase, protein; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor)	Q05655	5580	PRKCD	3p21.31	human	T507	PHOSPHORYLATION	447511	FGESRAStFCGTPDY	Pkinase	phosphorylation; enzymatic activity, induced	apoptosis, altered			4338205; 5121503; 1976301	38	17	104	in B cells fom CLL patients; PKCD T507A mutant caused apoptosis in transfected HEK293T cells, similar to the wild-type.  ; required for Y313 phosphorylation; T507A mutant is unable to activate NFkB and AP1-1 in reporter assays.  T507A also showed a substrate selection defect of pMARKS but not in pCREB phosphorylation. 	
RPS3	Apoptosis; Ribosomal protein; Translation	P23396	6188	RPS3	11q13.3-q13.5	human	R64	DI-METHYLATION	9184301	NVLGEKGrRIRELTA	KH_2	intracellular localization				8164811	1	0	0	regulates ribosome assembly	
KIR3DL1	Membrane protein, integral; Receptor, misc.	P43629	3811	KIR3DL1	19q13.4	human	S385	PHOSPHORYLATION	990304	AGNRTANsEDSDEQD		activity, induced; receptor internalization, altered				970025	1	0	0		
Akt1	EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor)	P31749	207	AKT1	14q32.32	human	K8	UBIQUITINATION	12723503	MSDVAIVkEGWLHKR	PH	intracellular localization; phosphorylation; enzymatic activity, induced				12517340	1	1	0	promotes Akt membrane recruitment and phosphorylation, resulting in activation	
EPS8	Adaptor/scaffold	Q08509	13860	Eps8		mouse	T628	PHOSPHORYLATION	9467900	SAPSPPPtPAPVPVP		intracellular localization	cytoskeletal reorganization			9158114	1	0	1		
CCNE1	Activator protein; Nuclear receptor co-regulator	P24864	898	CCNE1	19q12	human	S387	PHOSPHORYLATION	454413	LSEQNRAsPLPSGLL		protein degradation				4278	2	7	1		
Etk	EC 2.7.10.2; KINASE; Kinase, protein; Protein kinase, TK; Protein kinase, tyrosine (non-receptor)	P51813	660	BMX	Xp22.2	human	Y566	PHOSPHORYLATION	448067	RYVLDDQyVSSVGTK	Pkinase_Tyr	molecular association, regulation	cell growth, altered	STAT3(INDUCES); PIK3R1(INDUCES)		1472; 2986	2	1	5		
CTNND1	Actin binding protein; Adaptor/scaffold; Cell adhesion; G protein regulator, misc.; Motility/polarity/chemotaxis	P30999	12388	Ctnnd1		mouse	Y257	PHOSPHORYLATION	450397	APSRQDVyGPQPQVR			cell cycle regulation; cell motility, altered			2790302	2	18	713		
Gab2	Adaptor/scaffold	Q9UQC2	9846	GAB2	11q14.1	human	T391	PHOSPHORYLATION	448383	ATIPRRNtLPAMDNS		molecular association, regulation; intracellular localization; activity, inhibited; phosphorylation	cell growth, altered	14-3-3 beta(INDUCES); Shc1(DISRUPTS); Grb2(DISRUPTS); EGFR(DISRUPTS)		6315402	1	9	51		
MSK1	EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor)	Q8C050	73086	Rps6ka5		mouse	T645	PHOSPHORYLATION	448217	PDNQPLKtPCFTLHY	Pkinase	enzymatic activity, induced				9060	12	1	0		
AATF	Transcription factor	Q9NY61	26574	AATF	17q12	human	S477	PHOSPHORYLATION	3753303	ELIERKTsSLDPNDQ	TRAUB	protein stabilization; molecular association, regulation	apoptosis, inhibited; transcription, altered	NFkB-p65(INDUCES)	DNA(INDUCES)	9225	1	0	0		
CD84	Cell surface; Immunoglobulin superfamily; Membrane protein, integral; Motility/polarity/chemotaxis	Q9UIB8	8832	CD84	1q24	human	Y279	PHOSPHORYLATION	450870	AASKKTIyTYIMASR		molecular association, regulation	cell growth, altered	SH2D1B(INDUCES); SH2D1A(INDUCES)		3033	1	5	282		
PGC-1 alpha	Nuclear receptor co-regulator; Transcription, coactivator/corepressor	Q9UBK2	10891	PPARGC1A	4p15.1	human	S266	PHOSPHORYLATION	448008	SLPLTPEsPNDPKGS		protein stabilization				1382	3	1	0		
SKAR	RNA binding protein	Q9BY77	84271	POLDIP3	22q13.2	human	S383	PHOSPHORYLATION	454010	ELPRRVNsASSSNPP		activity, induced		ERH(NOT_REPORTED)		2537401; 4156	1	1	8	phosphorylation of this site is involved in the control of cell growth	
Deptor	Apoptosis	Q8TB45	64798	DEPTOR	8q24.12	human	S291	PHOSPHORYLATION	4723858	CGSSGYFsSSPTLSS		protein degradation; molecular association, regulation; ubiquitination		BTRC(INDUCES); FBW1B(INDUCES)		21699401; 21683709	2	1	0		
BORA	Activator protein	Q6PGQ7	79866	BORA	13q22.1	human	T501	PHOSPHORYLATION	2512943	QMDSGYNtQNCGSNI	PRCH	protein degradation; molecular association, regulation	cell cycle regulation	BTRC(INDUCES)		2451810; 7532700	2	0	0	PLK1 phosphorylation of site promotes BORA interaction with, and degradation by, BTRC (SCF-beta-TrCP ligase)	
KIF11	Microtubule binding protein; Motor protein	P52732	3832	KIF11	10q24.1	human	T926	PHOSPHORYLATION	448410	LDIPTGTtPQRKSYL	Microtub_bind	intracellular localization				1332	4	14	2	regulates association with the spindle apparatus	
PKCD	EC 2.7.10.2; EC 2.7.11.13; KINASE; Kinase, protein; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor)	P28867	18753	Prkcd		mouse	Y64	PHOSPHORYLATION	447581	TTFDAHIyEGRVIQI		molecular association, regulation; intracellular localization; enzymatic activity, inhibited	carcinogenesis, inhibited; apoptosis, induced	KPNA2(INDUCES)		3434; 22518516; 1171; 1713115	6	1	28	PKCD-induced apoptosis	
CAMKK1	EC 2.7.11.17; KINASE; Kinase, protein; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor)	P97756	60341	Camkk1		rat	S458	PHOSPHORYLATION	486077	KSMLRKRsFGNPFEP		molecular association, regulation; enzymatic activity, inhibited		calmodulin(DISRUPTS)		12482208	4	12	13		
Myt1	EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, Other; Protein kinase, dual-specificity	Q99640	9088	PKMYT1	16p13.3	human	T412	PHOSPHORYLATION	11331001	QPLGPPAtPPGSPPC		molecular association, regulation		Pin1(INDUCES)		7981800	1	0	0		
RCHY1	EC 6.3.2.-; EC 6.3.2.19; Nuclear receptor co-regulator; UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase	Q96PM5	25898	RCHY1	4q21.1	human	S155	PHOSPHORYLATION	483982	CLEDIHTsRVVAHVL	zf-RING_2	ubiquitination; intracellular localization; enzymatic activity, inhibited	cell growth, altered	p53(DISRUPTS)		12004	1	1	0	cytoplasmic localization	
ASIC1	Channel, cation; Membrane protein, integral; Membrane protein, multi-pass	P55926	79123	Accn2		rat	S476	PHOSPHORYLATION	458230	CQKEAKRsSADKGVA		activity, inhibited	apoptosis, altered			7326	1	0	0		
Lck	EC 2.7.10.2; KINASE; Kinase, protein; Protein kinase, TK; Protein kinase, tyrosine (non-receptor)	P06240	16818	Lck		mouse	Y394	PHOSPHORYLATION	447822	RLIEDNEyTAREGAK	Pkinase_Tyr	molecular association, regulation; phosphorylation; enzymatic activity, induced	cell motility, altered	BAT3(INDUCES)		1163206; 3351; 26341713; 6041; 1150	33	57	2953	promotes EGFR, MEK, and ERK phosphorylation	
SMURF1	EC 6.3.2.-; EC 6.3.2.19; Ligase; UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase	Q9CUN6	75788	Smurf1		mouse	T306	PHOSPHORYLATION	18156100	VDHNNRTtQFTDPRL	WW	intracellular localization	cell growth, altered			18021028	1	0	0	; alters SMURF1 substrate affinity and preference;  contributes to neuronal polarization by promoting axon formation	
BAD	Apoptosis	O35147	64639	Bad		rat	S129	PHOSPHORYLATION	447861	EGMEEELsPFRGRSR	Bcl-2_BAD	molecular association, regulation	apoptosis, induced	14-3-3 zeta(DISRUPTS)		5915	7	6	19		
SIK	EC 2.7.11.1; KINASE; Kinase, protein; Motility/polarity/chemotaxis; Protein kinase, CAMK; Protein kinase, Ser/Thr (non-receptor)	Q9R1U5	59329	Sik1		rat	S577	PHOSPHORYLATION	465992	FQEGRRAsDTSLTQG		intracellular localization	transcription, induced; transcription, altered			27519653; 8812; 8810	8	7	4	Wild-type and S577A mutant induce MEF2 transcriptional activity and are nuclear localized.; S577 may be involved in nuclear export from the nucleus. 	
Bcl-10	Apoptosis; Transcription, coactivator/corepressor	O95999	8915	BCL10	1p22	human	S134	PHOSPHORYLATION	467254	DGATNNLsRSNSDES		molecular association, regulation		MALT1(DISRUPTS)		8189	3	4	3		
NPAT	Cell cycle regulation; Transcription regulation	Q14207	4863	NPAT	11q22-q23	human	T1350	PHOSPHORYLATION	2286401	ISRTTSAtPLKDNTQ			transcription, induced			2285900	1	1	3	multiple sites deletion mutant	
CSFR	EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Protein kinase, TK; Protein kinase, tyrosine (receptor)	P09581	12978	Csf1r		mouse	Y559	PHOSPHORYLATION	450118	ERYEGNSyTFIDPTQ		activity, induced; protein degradation; molecular association, regulation; enzymatic activity, induced; phosphorylation	cell cycle regulation; cell differentiation, altered; cell motility, altered; apoptosis, inhibited; cytoskeletal reorganization; transcription, induced; transcription, altered; cell growth, altered	Cbl(INDUCES); Src(INDUCES); Gab2(INDUCES); PIK3R1(INDUCES); Grb2(INDUCES)		4651302; 3340207; 1342; 1173037; 20655019; 2718	10	1	6		
WDR77	Adaptor/scaffold; Nuclear receptor co-regulator; Transcription, coactivator/corepressor	Q9BQA1	79084	WDR77	1p13.2	human	T5	PHOSPHORYLATION	471217	___MRKEtPPPLVPP			carcinogenesis, altered			17722104	1	35	45	in CCND1 T286A mutant 	
ACP1	Cofactor and Vitamin Metabolism - riboflavin; EC 3.1.3.2; EC 3.1.3.48; Motility/polarity/chemotaxis; PHOSPHATASE; Phosphatase (non-protein); Protein phosphatase, tyrosine (non-receptor)	P24666	52	ACP1	2p25	human	Y133	PHOSPHORYLATION	457445	LIIEDPYyGNDSDFE	LMWPc	molecular association, regulation; phosphorylation; enzymatic activity, induced	cell motility, altered; cell adhesion, altered; cell growth, altered	Grb2(INDUCES)		8617; 5395700; 8616; 8170	5	6	87		
CDH13	Cell adhesion; Membrane protein, anchored	Q9WTR5	12554	Cdh13		mouse	Y327	PHOSPHORYLATION	486281	ETLENPKyELIIEAQ	Cadherin	protein degradation				12067	1	0	0	S327F mutant is resistant to proteosomal degradataion	
IkB-alpha	DNA binding protein; Inhibitor protein	Q63746	25493	Nfkbia		rat	S36	PHOSPHORYLATION	448204	RHDSGLDsMKDEDYE		activity, induced	apoptosis, altered; transcription, altered			1962901; 1919610	80	1	5	A S32A,S36A double mutant of IkBA inhibits the NFkB/p65-induced increase in dor (delta opiod receptor) promoter transcription; Cells expressing IKBa S32A S36A are more susceptible to apoptosis while in suspension  than cells expressing wt IKBa.	
SIAH2	EC 6.3.2.-; EC 6.3.2.19; Ligase; Transcription, coactivator/corepressor; UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase	O43255	6478	SIAH2	3q25	human	S28	PHOSPHORYLATION	471339	PQPQHTPsPAAPPAA		protein degradation; molecular association, regulation; intracellular localization; enzymatic activity, induced	cytoskeletal reorganization	HIPK2(DISRUPTS)		5354423; 26341714	5	1	0		
C/EBP-beta	DNA binding protein; Motility/polarity/chemotaxis; Transcription factor	P21272	24253	Cebpb		rat	S273	PHOSPHORYLATION	13373502	QKKVEQLsRELSTLR	Nup54; DUF2730; bZIP_2; HALZ	molecular association, regulation	cell cycle regulation; transcription, induced	C/EBP-beta(INDUCES)	DNA(INDUCES)	13354731	1	1	1		
NEDD1	Cell cycle regulation	Q8NHV4	121441	NEDD1	12q23.1	human	S397	PHOSPHORYLATION	4272994	GKNQDFSsFDDTGKS		molecular association, regulation	cell cycle regulation			9201031	1	6	1	important for binding of NEDD1 with gamma-tubulin	
GATA3	Transcription factor	P23771	2625	GATA3	10p15	human	S308	PHOSPHORYLATION	456464	IKPKRRLsAARRAGT		activity, induced	transcription, induced			6725	1	0	0		
C/EBP-beta	DNA binding protein; Motility/polarity/chemotaxis; Transcription factor	P17676	1051	CEBPB	20q13.1	human	T235	PHOSPHORYLATION	447878	SSSSPPGtPSPADAK		activity, induced; molecular association, regulation	cell differentiation, altered; transcription, induced; transcription, altered	EHMT2 iso4(DISRUPTS)		16823900; 6762; 10353917; 3342603; 1486	28	5	0	activates transcription of MMP-1 gene; T235 phosphorylation  occurs in nuclei of differentiated macrophages, but not in monocytes.  	
NEK6	EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor)	Q9HC98	10783	NEK6	9q33.3-q34.11	human	S206	PHOSPHORYLATION	448024	SETTAAHsLVGTPYY	Pkinase	activity, induced				2298	3	6	41		
SSRP1	Transcription initiation complex; Transcription, coactivator/corepressor	Q08945	6749	SSRP1	11q12	human	S657	PHOSPHORYLATION	456295	KSSSRQLsESFKSKE		activity, inhibited	transcription, altered			4408	1	5	2		
CACNA1C	Channel, calcium; Membrane protein, integral; Membrane protein, multi-pass	P15381	100101555	CACB		rabbit	S1517	PHOSPHORYLATION	460572	DYLTRDWsILGPHHL		activity, induced				8157; 7646	4	0	0		
FcRL4	Membrane protein, integral	Q96PJ5	83417	FCRL4	1q21	human	Y463	PHOSPHORYLATION	22730004	PKKGDLVySEIQTTQ			signaling pathway regulation			22723938	1	0	0	all 3 sites (Y451, Y463, Y493) inhibits BCR signaling and enhances TLR9 signaling	
CAMK2A	EC 2.7.11.17; KINASE; Kinase, protein; Protein kinase, CAMK; Protein kinase, Ser/Thr (non-receptor)	P11798	12322	Camk2a		mouse	T306	PHOSPHORYLATION	449596	LKGAILTtMLATRNF		intracellular localization				1965	13	6	1		
InsR	EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Protein kinase, TK; Protein kinase, tyrosine (receptor)	P15208	16337	Insr		mouse	Y1179	PHOSPHORYLATION	447681	RDIYETDyYRKGGKG	Pkinase_Tyr		cell cycle regulation; cell motility, altered			2790302	35	25	697		
AML3 iso5	DNA binding protein; Transcription factor	Q08775-5	12393	Runx2		mouse	S319	PHOSPHORYLATION	10892802	SYLSQMTsPSIHSTT		activity, induced	transcription, induced			22495306; 14562606	6	1	0		
PEA-15	Apoptosis; Motility/polarity/chemotaxis	Q15121	8682	PEA15	1q21.1	human	S116	PHOSPHORYLATION	450281	KDIIRQPsEEEIIKL		protein stabilization	apoptosis, inhibited; autophagy, altered; signaling pathway regulation			2934; 2665611; 14987304	8	46	1052	PEA phosphorylation is required for JNK activity.	
CLCN2	Channel, chloride; Membrane protein, integral; Membrane protein, multi-pass	P51788	1181	CLCN2	3q27-q28	human	S76	PHOSPHORYLATION	2902201	CARCRVCsVRCHKFL		activity, induced				8378	1	0	0		
GATA1	DNA binding protein; Transcription factor	P17679	14460	Gata1		mouse	S310	PHOSPHORYLATION	451231	QTRNRKAsGKGKKKR			cell differentiation, altered; transcription, induced			6990	7	0	0	S310A acts like a dominant negative mutation on EpoR-induced differentiation.	
SF1	RNA binding protein; RNA splicing; Spliceosome; Transcription, coactivator/corepressor	Q15637-2	7536	SF1	11q13	human	S20	PHOSPHORYLATION	449919	PSKKRKRsRWNQDTM		protein conformation	RNA splicing, altered	U2AF1(DISRUPTS)		2471	2	1	0	The structure of the complex suggests that a combination of steric interference and unfavorable electrostatic contacts of the phosphorylated S20 with the negatively charged helix A in U2AF-RMM3/SF1.  	
ERG	DNA binding protein; Transcription factor	P11308-3	2078	ERG	21q22.3	human	S222	PHOSPHORYLATION	9429097	VDKALQNsPRLMHAR			transcription, induced			28761500	0	4	2		
SHP-2	EC 3.1.3.48; Motility/polarity/chemotaxis; PHOSPHATASE; Protein phosphatase, tyrosine (non-receptor)	P35235	19247	Ptpn11		mouse	Y584	PHOSPHORYLATION	448493	REDSARVyENVGLMQ		molecular association, regulation; phosphorylation; enzymatic activity, induced		Grb2(INDUCES)		3502; 4651314	13	38	1132	ERK phosphorylation/activation	
ICAM3	Cell adhesion; Immunoglobulin superfamily; Membrane protein, integral	P32942	3385	ICAM3	19p13.3-p13.2	human	S525	PHOSPHORYLATION	451213	SYHVREEsTYLPLTS		molecular association, regulation; intracellular localization		NHERF(NOT_REPORTED)		3443	1	1	13		
PR	DNA binding protein; Nuclear receptor	P06401	5241	PGR	11q22-q23	human	S81	PHOSPHORYLATION	450160	TQDQQSLsDVEGAYS	Prog_receptor	molecular association, regulation	transcription, induced		DNA(INDUCES)	7324125; 28722425	4	0	0	WNT1 transcription	
NEK9	Autophagy; EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor)	Q8TD19	91754	NEK9	14q24.3	human	T210	PHOSPHORYLATION	451116	SEYSMAEtLVGTPYY	Pkinase	enzymatic activity, induced	cell cycle regulation			3317; 7008	4	0	0		
GCET2	Unknown function	Q8N6F7	257144	GCSAM	3q13.2	human	Y148	PHOSPHORYLATION	463675	ARSPEDEyELLMPHR			cell motility, altered	MYO3A(INDUCES); MYO5B(INDUCES)		762720	1	4	186		
Dok1	Adaptor/scaffold; Motility/polarity/chemotaxis	Q99704	1796	DOK1	2p13	human	S443	PHOSPHORYLATION	454883	ATGSGIKsHNSALYS		phosphorylation	cell motility, altered; cell growth, altered			4367	1	0	0		
BORA	Activator protein	Q6PGQ7	79866	BORA	13q22.1	human	S274	PHOSPHORYLATION	9318308	TSPSPISsPTFSPIE		protein degradation; molecular association, regulation	cell cycle regulation	Pin1(INDUCES)		28722159; 27623410	2	2	0	required for mitotic entry	
IkB-beta	Inhibitor protein	Q15653	4793	NFKBIB	19q13.1	human	S315	PHOSPHORYLATION	452014	SGPCSSSsDSDSGDE		activity, induced; intracellular localization	transcription, altered; transcription, inhibited	CCDC32(INDUCES)		4914012; 3925; 12482224	3	0	0	Phosphorylation blocks NF-kB-directed transcription.; and in vivo, NFkB/Rel activation 	
PKR	EC 2.7.10.2; EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor); Translation	P19525	5610	EIF2AK2	2p22-p21	human	Y101	PHOSPHORYLATION	458271	EGLSMGNyIGLINRI	dsrm	enzymatic activity, induced	translation, altered; cell growth, altered			7342	1	1	0		
Kv7.1	Channel, potassium; Membrane protein, integral; Membrane protein, multi-pass	P51787	3784	KCNQ1	11p15.5	human	S27	PHOSPHORYLATION	2999203	LPGARRGsAGLAKKC		activity, induced; protein conformation				8604; 22495307	2	1	0		
GluR1	Channel, calcium; Channel, ligand-gated; Membrane protein, integral; Membrane protein, multi-pass	P42261	2890	GRIA1	5q31.1	human	S849	PHOSPHORYLATION	448565	FCLIPQQsINEAIRT		activity, induced				4214818	64	2	3	GluR1 currents are enhanced by AKAPS.	
tau iso8	Cytoskeletal protein	P10636-8	4137	MAPT	17q21.1	human	S305	PHOSPHORYLATION	487457	KHVPGGGsVQIVYKP	Tubulin-binding	molecular association, regulation				19084437	2	1	0	in vitro microtubule binding	
TACC3	Cell cycle regulation	Q9Y6A5	10460	TACC3	4p16.3	human	S558	PHOSPHORYLATION	474537	ESALRKQsLYLKFDP		intracellular localization				11966	6	5	24	changed localization in the presence of MLN8054	
P2RY1	GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR	P47900	5028	P2RY1	3q25.2	human	S354	PHOSPHORYLATION	1985600	EANLQSKsEDMTLNI		receptor internalization, altered				17482924	1	1	0		
ARHGEF4 iso3	Guanine nucleotide exchange factor, Rac/Rho; Motility/polarity/chemotaxis	Q9NR80-3	50649	ARHGEF4	2q22	human	Y94	PHOSPHORYLATION	3333400	VGSEEDLyDDLHSSS		activity, induced				3301233	1	0	0	important for EGF-induced activation of Rac1 and Cdc42	
APS	Adaptor/scaffold	Q9Z200	114203	Sh2b2		rat	Y618	PHOSPHORYLATION	448842	ARAVENQySFY____		molecular association, regulation		Cbl-c(INDUCES)		2012	2	2	5		
KIF23 iso2	Microtubule binding protein; Motility/polarity/chemotaxis; Motor protein	Q02241-2	9493	KIF23	15q23	human	S710	PHOSPHORYLATION	470674	LRHRRSRsAGDRWVD		molecular association, regulation	cell cycle regulation	14-3-3 zeta(INDUCES); 14-3-3 gamma(INDUCES)		14551400	3	4	0		
MOK	EC 2.7.11.22; KINASE; Kinase, protein; Protein kinase, CMGC; Protein kinase, Ser/Thr (non-receptor)	Q9WVS4	26448	Rage		mouse	T159	PHOSPHORYLATION	450005	VYSKQPYtEYISTRW	Pkinase	activity, induced				2553	1	0	0	While the authors did not prove that these sites were phosphorylated, mutation of both T159 and Y161, located in the activation loop, abolished the enzymatic activity of the kinase.	
NCoA2	Motility/polarity/chemotaxis; Transcription, coactivator/corepressor	Q15596	10499	NCOA2	8q13.3	human	S469	PHOSPHORYLATION	4728825	NYALKMNsPSQSSPG			transcription, induced			22723912	1	5	2		
PML	Transcription factor; Tumor suppressor; Ubiquitin conjugating system	P29590	5371	PML	15q22	human	S562	PHOSPHORYLATION	6835502	RVVVISSsEDSDAEN	DUF3583	molecular association, regulation		SUMO2(INDUCES); SUMO1(INDUCES)		6829202	2	3	0		
PKR	EC 2.7.10.2; EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor); Translation	P19525	5610	EIF2AK2	2p22-p21	human	T258	PHOSPHORYLATION	448087	DMKETKYtVDKRFGM		enzymatic activity, induced				754; 9075	2	0	0		
MEF2C iso3	DNA binding protein; Transcription factor	Q06413-3	4208	MEF2C	5q14.3	human	T293	PHOSPHORYLATION	448000	QSAQSLAtPVVSVAT		activity, induced	transcription, altered			2273	1	0	0		
PDE3A	EC 3.1.4.17; Membrane protein, integral; Membrane protein, multi-pass; Nucleotide Metabolism - purine; Phosphodiesterase	Q9Z0X4	54611	Pde3a		mouse	S290	PHOSPHORYLATION	471415	GWKRRRRsSSVVAGE		enzymatic activity, induced				9112	1	0	9	required for insulin-dependent Xenopus oocyte maturation; 
activated during oocytes maturation in mouse treated with hCG 	
CCNT1	Transcription initiation complex	O60563	904	CCNT1	12q13.11	human	S564	PHOSPHORYLATION	28735106	KTYSLSSsFSSSSST		enzymatic activity, inhibited	transcription, inhibited			28722122	1	1	0	inhibits the kinase activity of cyclin T1/Cdk9 complex	
STMN2	Cytoskeletal protein	P21818	84510	Stmn2		rat	S62	PHOSPHORYLATION	450174	ELILKPPsPISEAPR	Stathmin		cytoskeletal reorganization			5546	5	5	0		
Notch 1	Membrane protein, integral; Motility/polarity/chemotaxis; Receptor, misc.; Transcription factor	Q01705	18128	Notch1		mouse	K2164	ACETYLATION	18899510	ACGSKEAkDLKARRK		protein stabilization; ubiquitination				18899000	1	1	0		
NuMA-1	Cell cycle regulation; Motility/polarity/chemotaxis	Q14980	4926	NUMA1	11q13	human	T2055	PHOSPHORYLATION	472502	MAFSILNtPKKLGNS			cytoskeletal reorganization			28722423	3	14	15	cortical NuMA/dynein localization, proper metaphase spindle positioning	
P2Y2	GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR; Receptor, misc.	P41231	5029	P2RY2	11q13.5-q14.1	human	T344	PHOSPHORYLATION	2909201	GLRRSDRtDMQRIED		receptor desensitization, altered; intracellular localization				8702	1	0	0		
NHE1	Membrane protein, integral; Membrane protein, multi-pass; Motility/polarity/chemotaxis; Transporter	P19634	6548	SLC9A1	1p36.1-p35	human	S726	PHOSPHORYLATION	2509107	IDPASPQsPESVDLV		activity, induced	apoptosis, induced			4042530	3	8	3	regulates the apoptotic alkalinizing activity of NHE1	
NHE3	Membrane protein, integral; Membrane protein, multi-pass; Transporter	P26432	100009430	NHE-3		rabbit	S663	PHOSPHORYLATION	457469	TMRKRLEsFKSAKLG		activity, induced; intracellular localization				7010	2	0	0	Dexamthasone increases NHE-3 on the membrane surface in wild-type but not in S663A mutant. 	
SFRS5	RNA binding protein; RNA processing; Spliceosome	Q09167	29667	Sfrs5		rat	S86	PHOSPHORYLATION	3685800	GRGRGRYsDRFSSRR			RNA splicing, altered			5514	2	0	0		
BTG1	Cell cycle regulation	P62324	694	BTG1	12q22	human	S159	PHOSPHORYLATION	457381	ELLLGRTsPSKNYNM		molecular association, regulation	cell growth, altered	CAF-1A(INDUCES)		7061	1	1	0		
CREB	DNA binding protein; Transcription factor	P15337	81646	Creb1		rat	S111	PHOSPHORYLATION	451808	TIAESEDsQESVDSV			transcription, altered			3932	8	1	3		
YAP1	Transcription, coactivator/corepressor	P46937	10413	YAP1	11q13	human	Y407	PHOSPHORYLATION	473004	SGLSMSSySVPRTPD		protein stabilization; activity, inhibited	apoptosis, induced; transcription, inhibited	p73(INDUCES)	DNA(DISRUPTS)	2195486; 6115908	2	1	4		
TOP1	EC 5.99.1.2; Isomerase	P11387	7150	TOP1	20q12-q13.1	human	S21	PHOSPHORYLATION	2721301	ADFRLNDsHKHKDKH		enzymatic activity, induced				2704321	1	2	0	enhances DNA relaxation activity in vitro	
MAP9	Cell cycle regulation	Q49MG5	79884	MAP9	4q32.1	human	S289	PHOSPHORYLATION	15105800	SDENKENsFSADHVT			cell cycle regulation			15022715	1	1	0	required for centrosome integrity during mitosis	
TIF1A	Transcription initiation complex	Q9NYV6	54700	RRN3	16p12	human	S44	PHOSPHORYLATION	470000	LENDFFNsPPRKTVR	RRN3	activity, induced	transcription, altered			8849	2	9	9		
MCM3	DNA replication; EC 3.6.4.12	P25205	4172	MCM3	6p12	human	T722	PHOSPHORYLATION	449197	EEMPQVHtPKTADSQ		molecular association, regulation	cell cycle regulation		DNA(INDUCES)	21385515	2	29	56	T722 phosphorylation affects MCM3 loading onto chromatin, and MCM3 overexpression blocks S phase entry. 	
NCAM-L1	Cell adhesion; Membrane protein, integral	Q05695	50687	L1cam		rat	Y1153	PHOSPHORYLATION	466002	KRSKGGKySVKDKED	Bravo_FIGEY	molecular association, regulation; intracellular localization		ezrin(DISRUPTS)		4651304	2	0	0		
ANXA1	Calcium-binding protein; Lipid binding protein	P04083	301	ANXA1	9q21.13	human	S28	PHOSPHORYLATION	452053	YVQTVKSsKGGPGSA		intracellular localization				9201015	2	0	0		
PRC1	Cell cycle regulation; Cytoskeletal protein; Microtubule binding protein; Motility/polarity/chemotaxis	O43663	9055	PRC1	15q26.1	human	T616	PHOSPHORYLATION	7444691	TSGILNStNIQS___		molecular association, regulation		PLK1(INDUCES)		25785411	4	1	0	phosphorylation and docking site of PLK1	
GSTP1	EC 2.5.1.18; Other Amino Acids Metabolism - glutathione; Transferase; Xenobiotic Metabolism - drug metabolism - cytochrome P450; Xenobiotic Metabolism - metabolism by cytochrome P450	P09211	2950	GSTP1	11q13	human	Y8	PHOSPHORYLATION	459294	MPPYTVVyFPVRGRC	GST_N	protein conformation; enzymatic activity, induced				7613720	1	11	224		
IkB-beta	Inhibitor protein	Q60778	18036	Nfkbib		mouse	S23	PHOSPHORYLATION	447916	WCDSGLGsLGPDAAA		protein degradation				5520; 3970006	5	0	0		
PLCB3	Carbohydrate Metabolism - inositol phosphate; EC 3.1.4.11; Phospholipase	Q99JE6	29322	Plcb3		rat	S1105	PHOSPHORYLATION	448448	LDRKRNNsISEAKTR	PLC-beta_C	intracellular localization; enzymatic activity, inhibited				6902; 756	4	10	213		
Chk1	EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, CAMK; Protein kinase, Ser/Thr (non-receptor)	O14757	1111	CHEK1	11q24.2	human	S286	PHOSPHORYLATION	465527	TSGGVSEsPSGFSKH		intracellular localization	cell cycle regulation			5358618	5	5	13	 ; mitotic phosphorylation;  important for Chk1 translocation from the nucleus to the cytoplasm when S317 and S345 are dephosphorylated	
N-WASP	Adaptor/scaffold; Motility/polarity/chemotaxis	O08816	682507	Wasl		rat	S481	PHOSPHORYLATION	3149547	RSKAIHSsDEDEDDD			endocytosis, induced; cytoskeletal reorganization			27127703	2	9	1	Phosphorylation induces CK2-A1 and N-WASP complex formation and regulate cell surface EGFR levels by endocytosis.  Phosphorylation reduces actin polymerization.	
NCoA2	Motility/polarity/chemotaxis; Transcription, coactivator/corepressor	Q61026	17978	Ncoa2		mouse	S736	PHOSPHORYLATION	465446	TVKQEPAsPKKKENA			transcription, induced			7956	3	9	10	stimulates ER-mediated transcription and proliferation	
IRS1	Adaptor/scaffold; Motility/polarity/chemotaxis	P35568	3667	IRS1	2q36	human	S636	PHOSPHORYLATION	447506	SGDYMPMsPKSVSAP		intracellular localization				8915	32	12	1	via cell fractionation experiments	
PXN iso2	Adaptor/scaffold; Cell adhesion; Cytoskeletal protein; Motility/polarity/chemotaxis	P49023-2	5829	PXN	12q24.31	human	S83	PHOSPHORYLATION	451113	FIHQQPQsSSPVYGS	Paxillin		cell cycle regulation; carcinogenesis, altered; transcription, altered			15022718	7	24	36	regulates Erk1/2-induced cell proliferation and transcription	
ASIC1 iso1	Channel, cation; Membrane protein, integral; Membrane protein, multi-pass	P78348-1	41	ASIC1	12q12	human	S525	PHOSPHORYLATION	449558	QKEAKRSsADKGVAL		molecular association, regulation		PICK1(DISRUPTS)		2003	2	0	0		
FANCD2	DNA repair	Q9BXW9	2177	FANCD2	3p26	human	S222	PHOSPHORYLATION	447816	LPEILGDsQHADVGK			cell cycle regulation			1725	3	1	0	Phosphorylation of FANCD2 on S222 is required for the IR-inducible S phase checkpoint but not the G1/S or G2/M checkpoints	
REL	Transcription factor	Q04864	5966	REL	2p13-p12	human	S526	PHOSPHORYLATION	1980800	LENPSCNsVLDPRDL		activity, induced	transcription, induced			1975603	1	0	0	Double mutant S491A S494 is not responsive to NIK-induced activation of transcription at the IL-2 promoter.  The comparable site to S494 in mouse Rel is an alanine, so S491 may be the more important residue.	
CACNA1C	Channel, calcium; Membrane protein, integral; Membrane protein, multi-pass	P15381	100101555	CACB		rabbit	T1704	PHOSPHORYLATION	17620920	RAISGDLtAEEELDK		activity, induced				15785004	3	1	0	regulates basal activity of CACNA1C channels	
RRAD	G protein; G protein, monomeric, RGK	O88667	56437	Rrad		mouse	S299	PHOSPHORYLATION	457398	KMAFRAKsKSCHDLS		molecular association, regulation; intracellular localization		14-3-3 beta(DISRUPTS)		1172800	2	1	0		
CHOP	Autophagy; DNA binding protein; Transcription factor	P35638	1649	DDIT3	12q13.1-q13.2	human	S79	PHOSPHORYLATION	448090	EVTSTSQsPHSPDSS	CDC45; Peptidase_S64; Macoilin; Phlebovirus_NSM; IncA; DUF3450		transcription, altered			1027	1	1	0	CHOP-Gal-4 chimeric protein induced a reporter gene expression. 	
HSPB8		Q9UJY1	26353	HSPB8	12q24.23	human	S24	PHOSPHORYLATION	2201402	RRDPFRDsPLSSRLL		protein conformation				18898712	2	7	0	decrease chaperone activity	
NKG2A	Membrane protein, integral; Receptor, misc.	P26715	3821	KLRC1	12p13	human	Y8	PHOSPHORYLATION	455555	MDNQGVIySDLNLPP		molecular association, regulation; intracellular localization		SHP-1(INDUCES)		5439	1	0	0		
Daxx	Apoptosis; Nuclear receptor co-regulator; Transcription, coactivator/corepressor	Q9UER7	1616	DAXX	6p21.3	human	S668	PHOSPHORYLATION	448623	KKICTLPsPPSPLAS	Daxx	molecular association, regulation; intracellular localization		exportin 1(INDUCES)		4093; 4094	4	6	0		
RARA	DNA binding protein; Nuclear receptor; Transcription factor	P10276	5914	RARA	17q21	human	S461	PHOSPHORYLATION	455330	RSSPATHsP______		protein degradation; ubiquitination				4599	3	0	0		
RhoGDI alpha	Apoptosis; Cell adhesion; Cell development/differentiation; G protein regulator, misc.; Motility/polarity/chemotaxis	P52565	396	ARHGDIA	17q25.3	human	S34	PHOSPHORYLATION	467490	YKPPAQKsIQEIQEL	Rho_GDI	molecular association, regulation	cell adhesion, altered	RhoA(DISRUPTS)		14551411	4	11	0		
RSK2	EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor)	P18654	110651	Rps6ka3		mouse	T365	PHOSPHORYLATION	450151	DPEFTAKtPKDSPGI	Pkinase_C	enzymatic activity, induced				2852652	5	16	13		
CD40	Membrane protein, integral; Receptor, cytokine	P25942	958	CD40	20q12-q13.2	human	T254	PHOSPHORYLATION	451275	TAAPVQEtLHGCQPV		activity, induced; molecular association, regulation		TRAF2(INDUCES)		3339; 5349	2	0	0		
PTPRA iso2	EC 3.1.3.48; Membrane protein, integral; Motility/polarity/chemotaxis; PHOSPHATASE; Receptor protein phosphatase, tyrosine	P18433-2	5786	PTPRA	20p13	human	S180	PHOSPHORYLATION	447611	QAGSHSNsFRLSNGR		molecular association, regulation; phosphorylation; enzymatic activity, induced	cell growth, altered	PIK3CB(INDUCES); Src(INDUCES); PKCD(INDUCES); Grb2(DISRUPTS)		1710; 6474	6	8	0	promotes PTPRA tyrosine phosphorylation	
CD3Z	Membrane protein, integral; Receptor, misc.	P20963	919	CD247	1q24.2	human	Y142	PHOSPHORYLATION	448932	GKGHDGLyQGLSTAT	ITAM	molecular association, regulation; intracellular localization; phosphorylation		Shc1(INDUCES); PI4K2A(INDUCES)		7483302; 27519611; 7700; 2576201	7	15	417	colocalization with Lck greater in the center of the activation zone than at the periphery of cluster	
EpoR	EC 2.7.10.2; Membrane protein, integral; Receptor, cytokine	P19235	2057	EPOR	19p13.3-p13.2	human	Y454	PHOSPHORYLATION	455531	PTPPHLKyLYLVVSD		molecular association, regulation	apoptosis, inhibited	SHIP(INDUCES); SOCS3(INDUCES)		8833; 5412; 8494	5	0	0		
Cx43	Channel, misc.; Membrane protein, integral; Membrane protein, multi-pass; Motility/polarity/chemotaxis	P23242	14609	Gja1		mouse	S330	PHOSPHORYLATION	449994	AGSTISNsHAQPFDF		intracellular localization				8241	7	10	0	ischemia induces connexin43 dephosphorylation and its relocalization in the cell and as a result downregulates intracellular communication	
IL-8R B	GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR; Receptor, cytokine	P25025	3579	CXCR2	2q35	human	S353	PHOSPHORYLATION	451049	PSFVGSSsGHTSTTL		protein degradation; receptor desensitization, altered; receptor internalization, altered				3279	1	0	0		
TACE	EC 3.4.24.86; Membrane protein, integral; Motility/polarity/chemotaxis; Protease	P78536	6868	ADAM17	2p25	human	T735	PHOSPHORYLATION	449804	KPFPAPQtPGRLQPA		intracellular localization; enzymatic activity, induced	cell cycle regulation			12778825; 2351	11	4	2		
ERK7	EC 2.7.11.24; KINASE; Kinase, protein; Protein kinase, CMGC; Protein kinase, Ser/Thr (non-receptor)	Q8TD08	225689	MAPK15	8q24.3	human	Y177	PHOSPHORYLATION	459217	EDQAVTEyVATRWYR	Pkinase	enzymatic activity, induced				7695; 7693	2	6	20	minor effect; activated by c-Ret	
TOPBP1	DNA replication	Q92547	11073	TOPBP1	3q22.1	human	S1159	PHOSPHORYLATION	472408	EERARLAsNLQWPSC		molecular association, regulation; protein conformation	transcription, induced	ATR(DISRUPTS)		970028; 7889926	3	0	11	Phosphorylation and oligomerization induce enhancement of Ets-1 transcription and cooperation with TCF20.	
calmodulin	Calcium-binding protein	P62161	24242	Calm1		rat	T45	PHOSPHORYLATION	469598	RSLGQNPtEAELQDM	DUF2267; EF_hand_5; DUF1103; LNS2; TerB; Tenui_NCP; UPF0154	molecular association, regulation		CAMK2A(NOT_REPORTED)		8318	1	0	0	 no effects on CaM-kinase I and IV or  CaM-kinase kinase alpha activity. ; non-phosphorylated calmodulin activates CaM-kinase II more than calmodulin phosphorylated on T44 by CaM-kinase IV	
CaRHSP1	RNA binding protein	Q9Y2V2	23589	CARHSP1	16p13.2	human	S41	PHOSPHORYLATION	455702	LRGNVVPsPLPTRRT		molecular association, regulation; intracellular localization			DNA(DISRUPTS)	17675042	3	50	182	phosphomimetic S41D mutation abolishes the ssDNA binding in vitro and releases CaRHSP1 from stress granules	
H3	DNA binding protein	P68431	8350	HIST1H3A	6p22.1	human	K5	TRI-METHYLATION	1458621	___MARTkQTARKST		molecular association, regulation	transcription, altered	TAF140(DISRUPTS); UHRF1(INDUCES); CDC45L(DISRUPTS)		15562525; 20989500; 18378518	109	0	0	fluorescence polarization binding assay,  
H3K5me3/K10me3 showed a 5-fold lower affinity compared with the H354me0/K10me3 peptide.; H3T4-p antagonizes binding of TAF140 to H3K4me3 and association with mitotic chromosomes.	
Gab2	Adaptor/scaffold	Q9UQC2	9846	GAB2	11q14.1	human	Y614	PHOSPHORYLATION	449788	KSTGSVDyLALDFQP		molecular association, regulation	cell cycle regulation; transcription, altered	SHP-2(NOT_REPORTED); SHP-2(INDUCES)		6227; 2320; 3905; 3309500	6	3	45	 ; Binding of SHP-2 activates the MAPK pathway and transcription.; in the presence of GCSFR	
RRAD	G protein; G protein, monomeric, RGK	P55042	6236	RRAD	16q22	human	S257	PHOSPHORYLATION	457395	QIRLRRDsKEANARR		molecular association, regulation		calmodulin(INDUCES)		7055	1	0	0		
Smad1	DNA binding protein; Transcription factor	Q15797	4086	SMAD1	4q31	human	S187	PHOSPHORYLATION	451173	NSHPFPHsPNSSYPN	DUF605	intracellular localization				3385	3	0	0	Erk-mediated phosphorylation inhibits the nuclear accumulation of Smad1.	
NFkB-p65	DNA binding protein; Nuclear receptor co-regulator; Transcription factor	Q04206	5970	RELA	11q13	human	T254	PHOSPHORYLATION	450278	QVAIVFRtPPYADPS		activity, induced; protein stabilization; molecular association, regulation; intracellular localization	transcription, altered	Pin1(INDUCES)		2987	2	0	0		
ACC1	Carbohydrate Metabolism - propanoate; Carbohydrate Metabolism - pyruvate; EC 6.3.4.14; EC 6.4.1.2; Ligase; Lipid Metabolism - fatty acid biosynthesis	P11497	60581	Acaca		rat	S1215	PHOSPHORYLATION	449868	YGMTHVAsVSDVLLD	ACC_central	enzymatic activity, inhibited				2742	3	3	3		
MST4	EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, STE; Protein kinase, Ser/Thr (non-receptor)	Q9P289	51765	MST4	Xq26.2	human	T178	PHOSPHORYLATION	4274125	DTQIKRNtFVGTPFW	Pkinase	intracellular localization	cytoskeletal reorganization			7318600	1	9	45		
TSC2	Cell cycle regulation; GTPase activating protein, misc.; Nuclear receptor co-regulator; Tumor suppressor	P49815	7249	TSC2	16p13.3	human	S664	PHOSPHORYLATION	455575	KKTSGPLsPPTGPPG	Tuberin	molecular association, regulation		TSC1(DISRUPTS)		5496	4	4	1		
p53	Activator protein; DNA binding protein; Motility/polarity/chemotaxis; Nuclear receptor co-regulator; Transcription factor; Tumor suppressor	P04637	7157	TP53	17p13.1	human	S37	PHOSPHORYLATION	447532	NVLSPLPsQAMDDLM		activity, induced; protein stabilization; molecular association, regulation; protein conformation	apoptosis, altered; apoptosis, induced; transcription, induced; transcription, inhibited; transcription, altered	MDM2(DISRUPTS); PPP2CA(INDUCES); MDM2(INDUCES); CBP(INDUCES)		5197; 4775; 5004505; 5010605; 6404; 1934801; 4971005; 2437; 18378508	64	3	0		
E2F1	DNA binding protein; Transcription factor	Q01094	1869	E2F1	20q11.2	human	S31	PHOSPHORYLATION	447867	ALRLLDSsQIVIISA		protein stabilization				1336	2	0	0		
Gab2	Adaptor/scaffold	Q9UQC2	9846	GAB2	11q14.1	human	Y293	PHOSPHORYLATION	449528	ETDNEDVyTFKTPSN		molecular association, regulation		CrkL(INDUCES)		6227	1	10	166		
NFAT90	DNA binding protein; Transcription factor	Q9Z1X4	16201	Ilf3		mouse	T188	PHOSPHORYLATION	17734001	EKVLAGEtLSVNDPP	DZF	molecular association, regulation; intracellular localization	translation, altered	ILF2(DISRUPTS)		17675013	1	1	0		
Chk2	EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, CAMK; Protein kinase, Ser/Thr (non-receptor)	O96017	11200	CHEK2	22q12.1	human	S33	PHOSPHORYLATION	447549	TQSQGSSsQSQGISS	DUF966	molecular association, regulation; enzymatic activity, induced	cell cycle regulation	Chk2(INDUCES); PPP2CA(DISRUPTS)		13852010; 12176	10	1	0	S19A mutant shows impaired dimerization and does not promote Hdmx degradation	
DDR2	EC 2.7.1.112; EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Protein kinase, TK; Protein kinase, tyrosine (receptor)	Q16832	4921	DDR2	1q23.3	human	Y736	PHOSPHORYLATION	456861	FGMSRNLySGDYYRI	Pkinase_Tyr	phosphorylation				6843	1	5	436	Stimulates autophosphorylation.  Autophosphorylation induces Shc binding (site not determined).	
PPAR-alpha	DNA binding protein; Nuclear receptor	Q07869	5465	PPARA	22q13.31	human	S230	PHOSPHORYLATION	2902207	VKARVILsGKASNNP			transcription, altered			8755	1	0	0		
HIF2A	DNA binding protein; Transcription factor	P97481	13819	Epas1		mouse	T844	PHOSPHORYLATION	451301	PYLLPELtRYDCEVN	HIF-1a_CTAD		transcription, induced			3526	1	0	0		
Ron	EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Protein kinase, TK; Protein kinase, tyrosine (receptor)	Q04912	4486	MST1R	3p21.3	human	Y1353	PHOSPHORYLATION	456487	SALLGDHyVQLPATY		phosphorylation	cell growth, altered			4335	3	0	0		
p70S6K	EC 2.7.11.-; EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor); Translation	P67999	83840	Rps6kb1		rat	S447	PHOSPHORYLATION	448357	GSPRTPVsPVKFSPG		enzymatic activity, induced				6139; 5011214	90	23	211	Quadruple mutant was 20% protected  from inactivation by glucocorticoids. 	
ULK1	Autophagy; EC 2.7.1.37; EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor)	O75385	8408	ULK1	12q24.3	human	S758	PHOSPHORYLATION	483139	PVVFTVGsPPSGSTP		molecular association, regulation	autophagy, altered	AMPKA1(INDUCES)		18668217	1	7	2		
MKP-7	EC 3.1.3.16; EC 3.1.3.48; Protein phosphatase, dual-specificity	Q9BY84	80824	DUSP16	12p13	human	S446	PHOSPHORYLATION	449606	TNKLCQFsPVQELSE		protein stabilization				4586	2	0	0		
SRF	Motility/polarity/chemotaxis; Transcription factor	P11831	6722	SRF	6p21.1	human	T159	PHOSPHORYLATION	449631	DNKLRRYtTFSKRKT	SRF-TF	activity, induced	transcription, induced; transcription, inhibited			10430801; 2263	2	0	0		
ROCK2	EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor)	Q28021	282041	ROCK2		cow	S1133	PHOSPHORYLATION	1732200	LHIGLDSsSIGSGPG		enzymatic activity, induced	cell cycle regulation			12177	1	1	0	alanine mutation of all 4 sites	
CACNA1B	Channel, calcium; Membrane protein, integral; Membrane protein, multi-pass	Q02294	257648	Cacna1b		rat	S2108	PHOSPHORYLATION	465549	RKQERGRsQERRQPS		activity, induced				6337819; 7994	2	0	0		
CD3E	Membrane protein, integral; Receptor, misc.	P22646	12501	Cd3e		mouse	Y170	PHOSPHORYLATION	448918	PPVPNPDyEPIRKGQ	ITAM	molecular association, regulation		PIK3R1(INDUCES)		3942	4	11	394		
DRD3	GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR	P35462	1814	DRD3	3q13.3	human	S229	PHOSPHORYLATION	482885	RILTRQNsQCNSVRP	7tm_1	receptor desensitization, altered; receptor internalization, altered				11766	2	0	1		
BLNK	Adaptor/scaffold	Q9YGC1	395733	BLNK		chicken	S173	PHOSPHORYLATION	7603516	PKKPSLPsPAAKPKL		phosphorylation	transcription, altered			7543511	1	1	0		
PDGFRB	EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Protein kinase, TK; Protein kinase, tyrosine (receptor)	P09619	5159	PDGFRB	5q33.1	human	Y1009	PHOSPHORYLATION	447522	LDTSSVLyTAVQPNE		activity, induced; molecular association, regulation; phosphorylation	cell growth, altered	Cbl(INDUCES); PLCG1(INDUCES); SHP-2(INDUCES); PIK3R1(DISRUPTS); CIN85(INDUCES); RASA1(DISRUPTS)		6024; 3478; 1173023; 1230; 6513; 744; 7451003; 2023; 1691	16	0	0	Stimulation with EGF or PDGF SH3SKP1 induced minimal increase in association. Association is constitutive in tumor cell lines.; Y1009 and Y1021 phosphorylation mediates PDGFBB and thrombin induced calcium signaling. 	
HDAC4	DEACETYLASE; Deacetylase; EC 3.5.1.98; Hydrolase; Nuclear receptor co-regulator	P56524	9759	HDAC4	2q37.3	human	S210	PHOSPHORYLATION	2631600	YGKTQHSsLDQSSPP			transcription, altered			2630604	1	3	0		
CTNNB1	Actin binding protein; Cell adhesion; Motility/polarity/chemotaxis; Nuclear receptor co-regulator; Transcription factor	P35222	1499	CTNNB1	3p21	human	Y142	PHOSPHORYLATION	449044	AVVNLINyQDDAELA	HEAT_2; RIX1	molecular association, regulation; intracellular localization		Bcl-9L(INDUCES)		4176	8	1	0		
EFNB2	Ligand, receptor tyrosine kinase; Membrane protein, integral	P52799	1948	EFNB2	13q33	human	Y311	PHOSPHORYLATION	447829	YEKVSGDyGHPVYIV	Shisa	protein stabilization; protein conformation				2363	1	7	114		
CDH2	Cell adhesion; Membrane protein, integral; Motility/polarity/chemotaxis	P15116	12558	Cdh2		mouse	Y884	PHOSPHORYLATION	450693	SSGGDQDyDYLNDWG	Cadherin_C	molecular association, regulation		Shc1(INDUCES)		3133	2	0	0		
GLRB	Channel, ligand-gated; Membrane protein, integral; Membrane protein, multi-pass	P48167	2743	GLRB	4q31.3	human	Y435	PHOSPHORYLATION	3078004	RDFELSNyDCYGKPI	Neur_chan_memb	activity, induced				8532	1	0	0		
TRPV5	Channel, cation; Membrane protein, integral; Membrane protein, multi-pass; Motility/polarity/chemotaxis	Q9NQA5	56302	TRPV5	7q35	human	S299	PHOSPHORYLATION	470108	FLELVVSsDKREARQ		activity, induced; intracellular localization				8913	3	0	0		
IRF3	DNA binding protein; Transcription factor	Q14653	3661	IRF3	19q13.3-q13.4	human	T404	PHOSPHORYLATION	449031	NSHPLSLtSDQYKAY		activity, induced; molecular association, regulation; intracellular localization; protein conformation; phosphorylation	transcription, altered	CBP(INDUCES)		2062; 6337817; 2195490; 12263	5	1	0		
RGS4	GTPase activating protein, RGS	Q0R4E4	100009014	RGS4		rabbit	S52	PHOSPHORYLATION	469585	VVVCQRVsQEEVKKW	Ribonuc_2-5A	molecular association, regulation; intracellular localization		G-alpha(q)(INDUCES)		8243	1	0	0		
DRD1	GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR	P18901	24316	Drd1		rat	S258	PHOSPHORYLATION	455302	VECAQSEsSFKMSFK	7tm_1	receptor desensitization, altered				4475	1	0	0		
CACNA1B	Channel, calcium; Membrane protein, integral; Membrane protein, multi-pass	Q02294	257648	Cacna1b		rat	S2126	PHOSPHORYLATION	467286	SEKQRFYsCDRFGSR		molecular association, regulation		14-3-3 gamma(INDUCES)		8228	1	0	0		
TOP1	EC 5.99.1.2; Isomerase	P11387	7150	TOP1	20q12-q13.1	human	S506	PHOSPHORYLATION	27276101	ADTVGCCsLRVEHIN	Topoisom_I	molecular association, regulation		ARF1(INDUCES)	DNA(INDUCES)	27257056; 27619375	2	0	0	ARF enhances the binding of hyperphosphorylated S506 to DNA. ; enhances relaxation of supercoiled DNA by increasing TOP1 DNA binding	
NPM1	RNA binding protein; Translation	Q61937	18148	Npm1		mouse	T198	PHOSPHORYLATION	448515	VKKSVRDtPAKNAQK	Daxx; NOA36; Nop14; TFIIF_alpha	molecular association, regulation; intracellular localization	cell cycle regulation; RNA splicing, altered; cytoskeletal reorganization	ROCK2(INDUCES)	RNA(INDUCES)	2582606; 12055200; 1903002	16	11	26	centrosome duplication	
PAK1	EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, STE; Protein kinase, Ser/Thr (non-receptor)	Q13153	5058	PAK1	11q13-q14	human	Y285	PHOSPHORYLATION	487520	QGASGTVyTAMDVAT	Pkinase	enzymatic activity, induced	apoptosis, altered; cell motility, induced; cell motility, altered			27519665; 12246	4	1	1	membrane ruffling;  closure of wounded monolayer; JAK2 tyrosine phosphorylation of PAK1 protects against apoptosis, and is required for maximal cell motility. 	
N-WASP	Adaptor/scaffold; Motility/polarity/chemotaxis	O08816	682507	Wasl		rat	S239	PHOSPHORYLATION	457322	LFDMCGIsEAQLKDR	PBD		cytoskeletal reorganization			7024	1	0	0	phosphorylation of this site plays a role in regulation of actin polymerization	
eEF-2	Translation; Translation elongation	P13639	1938	EEF2	19p13.3	human	T57	PHOSPHORYLATION	448040	RAGETRFtDTRKDEQ	GTP_EFTU	phosphorylation	translation, altered			7483316; 27127701	24	25	48		
TGFBR3	Membrane protein, integral	Q03167	7049	TGFBR3	1p33-p32	human	T843	PHOSPHORYLATION	455562	SIGSTQStPCSSSST		molecular association, regulation; receptor internalization, altered; intracellular localization		ARRB1(INDUCES)		5455	1	0	0		
MOB1B	Activator protein; Protein kinase, regulatory subunit	Q7L9L4	92597	MOB1B	4q13.3	human	T74	PHOSPHORYLATION	11555108	QINMLYGtITDFCTE	Mob1_phocein	molecular association, regulation		NDR1(INDUCES); LATS2(INDUCES)		11424218	1	0	0		
IGFBP1	Secreted; Secreted, signal peptide	P08833	3484	IGFBP1	7p13-p12	human	S144	PHOSPHORYLATION	451659	NFHLMAPsEEDHSIL		activity, induced; molecular association, regulation		IGF1(INDUCES)		4641413; 6804205; 27519669	5	5	0		
TIE1	EC 2.7.1.112; EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Protein kinase, TK; Protein kinase, tyrosine (receptor)	Q06806	21846	Tie1		mouse	Y1113	PHOSPHORYLATION	451279	MLEARKAyVNMSLFE		molecular association, regulation	transcription, altered	PIK3R1(INDUCES)		3501	1	0	0		
Akt3	EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor)	Q63484	29414	Akt3		rat	S34	PHOSPHORYLATION	484936	FLLKTDGsFIGYKEK	PH	enzymatic activity, inhibited				12052	1	5	0		
MafA	DNA binding protein; Transcription factor	Q8CF90	378435	Mafa		mouse	T53	PHOSPHORYLATION	1320402	PPGSLSStPLSTPCS		molecular association, regulation		MafA(INDUCES)	DNA(NOT_REPORTED)	13326312	3	1	0		
CTPS2	EC 6.3.4.2; Ligase; Nucleotide Metabolism - pyrimidine	Q9NRF8	56474	CTPS2	Xp22	human	S568	PHOSPHORYLATION	3213615	LSSSDRYsDASDDSF		enzymatic activity, inhibited				15235222	1	23	5		
SYN1	Vesicle protein	P09951	24949	Syn1		rat	Y301	PHOSPHORYLATION	478277	VVALTKTyATAEPFI	Synapsin_C	molecular association, regulation		Src(INDUCES); Fyn(INDUCES)		9624; 14784600	2	0	2	increases interaction with synaptic vesicles and actin filaments	
CELF1	Cell development/differentiation; RNA binding protein; RNA processing	Q92879	10658	CELF1	11p11	human	S28	PHOSPHORYLATION	3347300	GQVPRTWsEKDLREL	RRM_1	molecular association, regulation	translation, altered		RNA(INDUCES)	3309530	2	3	1	increases CUGBP1 binding to cyclin D1 mRNA 	
STAT6	DNA binding protein; Transcription factor	P42226	6778	STAT6	12q13	human	S707	PHOSPHORYLATION	17772900	IPPYQGLsPEESVNV		molecular association, regulation	transcription, inhibited		DNA(NOT_REPORTED)	17675008	1	0	0	suppresses transcriptional activity of STAT6	
GABBR1	GPCR, family 3; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR	Q9WV18	54393	Gabbr1		mouse	S867	PHOSPHORYLATION	15167000	ITRGEWQsEAQDTMK	Bap31; Orbi_VP5	receptor internalization, altered	endocytosis, altered			15022722	1	0	0		
ERK2	EC 2.7.11.24; KINASE; Kinase, protein; Protein kinase, CMGC; Protein kinase, Ser/Thr (non-receptor)	P63085	26413	Mapk1		mouse	Y185	PHOSPHORYLATION	447594	HTGFLTEyVATRWYR	Pkinase; YukC	enzymatic activity, induced	transcription, altered	Gab1(INDUCES)		1818; 4222; 4862602; 668; 5209; 5766; 6759; 6947; 5354414; 9199; 914	974	85	3953		
CENPJ	Cell cycle regulation; Microtubule binding protein; Transcription, coactivator/corepressor	Q9HC77	55835	CENPJ	13q12.12	human	S595	PHOSPHORYLATION	14918201	ISFSSNSsFVLKILE			cell cycle regulation			14780531	1	0	0	required for centriole elongation	
FcoR		P0DJI6	100503924	Fcor		mouse	T93	PHOSPHORYLATION	25244200	DLNSQRStCCCLLNA		acetylation; intracellular localization	transcription, inhibited			25227642	1	0	0	 suppresses expression of PGC-1alpha; increases FoxoO1 acetylation and inhibits its transcriptional activity	
DAB1	Adaptor/scaffold	Q8JH94	374083	DAB1		chicken	Y198	PHOSPHORYLATION	447629	EDVEDPVyQYIVFEA		phosphorylation	cytoskeletal reorganization			8417	10	1	0	increases Src activation and overall tyrosine phosphorylation levels in the cell, alters cellular morphology	
PLD1 iso2	EC 3.1.4.4; Lipid Metabolism - ether lipid; Lipid Metabolism - glycerophospholipid; Motility/polarity/chemotaxis; Phospholipase	Q13393-2	5337	PLD1	3q26	human	S2	PHOSPHORYLATION	448572	______MsLKNEPRV		intracellular localization; enzymatic activity, induced				2865425	4	0	0		
NFAT2	DNA binding protein; Transcription factor	O95644	4772	NFATC1	18q23	human	S245	PHOSPHORYLATION	448861	PSTSPRAsVTEESWL		intracellular localization; activity, inhibited; phosphorylation				2031; 4332502	2	2	1	phosphorylation creates predicted overlapping GSK3B phosphorylation sites	
MAN1	Membrane protein, integral; Membrane protein, multi-pass; Nuclear envelope	Q9Y2U8	23592	LEMD3	12q14	human	S402	PHOSPHORYLATION	3216873	GGAFSVDsPRIYSNS		molecular association, regulation		BAF(INDUCES)		6829226	1	8	0		
FGFR1	EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Protein kinase, TK; Protein kinase, tyrosine (receptor)	P11362	2260	FGFR1	8p12	human	Y653	PHOSPHORYLATION	447918	RDIHHIDyYKKTTNG	Pkinase_Tyr	phosphorylation; enzymatic activity, induced	cell differentiation, altered; cell motility, altered; cell growth, altered			675; 1962905	8	10	324	Double Y->F mutant has less neurite outgrowth in PC12 cells (differentiation), and less cell proliferation in L-6 cells.; Data collected by isolating phosphorylated species in vitro and confirming their phosphorylation states by mass spec. Y->F mutations were also done but unpublished.	
GAPDH	Carbohydrate Metabolism - glycolysis and gluconeogenesis; EC 1.2.1.12; EC 2.6.99.-; Oxidoreductase	P04406	2597	GAPDH	12p13	human	K227	ACETYLATION	461582	VIPELNGkLTGMAFR	Gp_dh_C	intracellular localization				14772324	1	2	5	nuclear translocation	
NR1I3	DNA binding protein; Nuclear receptor	Q14994	9970	NR1I3	1q23.3	human	S192	PHOSPHORYLATION	458347	LPIEDQIsLLKGAAV	Hormone_recep	intracellular localization				7362	1	0	1		
LC8	Microtubule binding protein; Motility/polarity/chemotaxis; Motor protein	P63168	56455	Dynll1		mouse	S88	PHOSPHORYLATION	454241	VAILLFKsG______	Dynein_light; TraH		cytoskeletal reorganization			4242	8	0	0		
SCN5A	Channel, sodium; Membrane protein, integral; Membrane protein, multi-pass	Q14524	6331	SCN5A	3p21	human	S525	PHOSPHORYLATION	451568	TSMKPRSsRGSIFTF	DUF3451	activity, induced				8548	3	1	0		
FLCN		Q76JQ2	303185	Flcn		rat	S302	PHOSPHORYLATION	3206871	ESESWDNsEAEEEEK		molecular association, regulation		AMPKA1(DISRUPTS)		10433001	1	5	0		
Jun	Transcription factor	P05412	3725	JUN	1p32-p31	human	T2	PHOSPHORYLATION	17737603	______MtAKMETTF			carcinogenesis, altered; cell growth, altered			17675043	1	0	0		
AQP9	Channel, misc.; Membrane protein, integral; Membrane protein, multi-pass	O43315	366	AQP9	15q	human	S222	PHOSPHORYLATION	477184	MNPARDLsPRLFTAL	MIP		cytoskeletal reorganization			9392	1	1	0	mutation decreases sensitivity to hypo-osmolar conditions and formation of filopodia	
GTF2I iso2	DNA binding protein; Transcription, coactivator/corepressor	P78347-2	2969	GTF2I	7q11.23	human	Y249	PHOSPHORYLATION	459606	ESEDPDYyQYNIQGS			cell cycle regulation; transcription, altered			8846	5	1	1		
MafA	DNA binding protein; Transcription factor	Q8NHW3	389692	MAFA	8q24.3	human	S14	PHOSPHORYLATION	1713900	MGAELPSsPLAIEYV		activity, induced	cell differentiation, altered; transcription, induced			12482241	2	2	0	activation of crystallin and NQO1 expression	
CCR5	GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Motility/polarity/chemotaxis; Receptor, GPCR; Receptor, cytokine	P51681	1234	CCR5	3p21.31	human	S337	PHOSPHORYLATION	448725	EAPERASsVYTRSTG		molecular association, regulation; receptor desensitization, altered; receptor internalization, altered		ARRB1(INDUCES); ARRB2(INDUCES)		2453; 3438; 5346	3	0	0		
Shc1	Adaptor/scaffold; Apoptosis; Mitochondrial; Motility/polarity/chemotaxis	P29353	6464	SHC1	1q21	human	T386	PHOSPHORYLATION	457351	PTAPNAQtPSHLGAT		protein stabilization	apoptosis, induced			7013	1	0	1	Phosphorylation necessary to promote activated-Rac1-induced oxidative stress (ROS-induced apoptosis).	
hnRNP K	RNA binding protein; RNA splicing; Spliceosome	P61979	15387	Hnrnpk		mouse	S116	PHOSPHORYLATION	452369	EEGLQLPsPTATSQL		intracellular localization				17482905	2	19	14		
ADCY6	Adenylyl cyclase; EC 4.6.1.1; Lyase; Membrane protein, integral; Membrane protein, multi-pass; Nucleotide Metabolism - purine	AAA40678	25289	Adcy6		rat	S746	PHOSPHORYLATION	467273	ALQRLSRsIVRSRVH		enzymatic activity, induced				8212; 8211	2	0	0		
AID	EC 3.5.4.5; Hydrolase	Q9GZX7	57379	AICDA	12p13	human	S38	PHOSPHORYLATION	457604	YVVKRRDsATSFSLD	APOBEC_N	enzymatic activity, induced				9140	10	3	0		
Chk1	EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, CAMK; Protein kinase, Ser/Thr (non-receptor)	O14757	1111	CHEK1	11q24.2	human	S317	PHOSPHORYLATION	447833	ENVKYSSsQPEPRTG		molecular association, regulation; enzymatic activity, induced	cell cycle regulation	claspin(INDUCES)		5407; 635; 4313621; 6842207; 9121; 4600	52	6	5	required for DNA replication fork progression	
mTOR	Autophagy; EC 2.7.11.1; KINASE; Kinase, protein; Motility/polarity/chemotaxis; Protein kinase, ATYPICAL; Protein kinase, Ser/Thr (non-receptor)	P42345	2475	MTOR	1p36.2	human	S2448	PHOSPHORYLATION	447578	RSRTRTDsYSAGQSV		intracellular localization; enzymatic activity, induced				7124723; 5820	90	6	84	nuclear translocation	
Rad51	DNA repair; Mitochondrial	Q06609	5888	RAD51	15q15.1	human	T309	PHOSPHORYLATION	455229	LRKGRGEtRICKIYD	Rad51		cell cycle regulation			4410	1	0	0		
YY1	C2H2-type zinc finger protein; Cell development/differentiation; Transcription factor	P25490	7528	YY1	14q	human	T348	PHOSPHORYLATION	3189352	KRHQLVHtGEKPFQC	IBR; Raffinose_syn; zf-H2C2_2	molecular association, regulation; intracellular localization			DNA(DISRUPTS)	10353936	1	5	5	in mitotic cells	
RGS13	GTPase activating protein, RGS	O14921	6003	RGS13	1q31.2	human	T41	PHOSPHORYLATION	15785722	SFENLMAtKYGPVVY	DUF4065; RGS	protein stabilization				15755109	1	1	0		
DAPK2	EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, CAMK; Protein kinase, Ser/Thr (non-receptor)	Q9UIK4	23604	DAPK2	15q22.31	human	S318	PHOSPHORYLATION	450028	VRRRWKLsFSIVSLC		molecular association, regulation	apoptosis, altered; apoptosis, inhibited	DAPK2(DISRUPTS); CAMK1A(DISRUPTS)		1049	1	2	0		
MDC1	Cell cycle regulation	Q14676	9656	MDC1	6p21.3	human	S329	PHOSPHORYLATION	453669	QPFGFIDsDTDAEEE		molecular association, regulation	cell cycle regulation	NBS1(INDUCES)		4042508	1	16	21	MDC1-NBS1 interaction regulates intra-S-phase checkpoint activation	
Cx43	Channel, misc.; Membrane protein, integral; Membrane protein, multi-pass; Motility/polarity/chemotaxis	P08050	24392	Gja1		rat	Y265	PHOSPHORYLATION	447815	KDCGSPKyAYFNGCS		molecular association, regulation; activity, inhibited	carcinogenesis, altered; cell adhesion, altered; cell growth, altered	Src(INDUCES)		8178; 5946; 8413; 15235238	11	1	10	 allows anchorage-independent growth; inhibits Src activity; disrupts gap junction communication	
ADRB3 iso2	GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR	P25962-2	11556	Adrb3		mouse	S388	PHOSPHORYLATION	456901	RQSPPLNsSLLREPR		activity, induced				6837	1	0	0	mutation of serines 388 and 389 to alanine abrogated cAMP accumulation in response to CL316243.	
SIT	Adaptor/scaffold; Membrane protein, integral	Q9Y3P8	27240	SIT1	9p13-p12	human	Y90	PHOSPHORYLATION	448963	SVEEVPLyGNLHYLQ		molecular association, regulation		Grb2(INDUCES)		12668809	1	7	345	Y90 is major binding site.	
ATP1A1	EC 3.6.3.9; Hydrolase; Membrane protein, integral; Membrane protein, multi-pass	P06685	24211	Atp1a1		rat	S16	PHOSPHORYLATION	449086	KYEPAAVsEHGDKKS		protein degradation; molecular association, regulation; enzymatic activity, inhibited; intracellular localization; protein conformation; enzymatic activity, induced		AP-2 alpha(INDUCES)		4023; 8253; 3245; 2200; 5329; 1910503; 8670	11	10	0	inhibited in LLCPK1 cells treated with dopamine ; activated in LLCPK1 cells treated with phorbol ester	
ASIC1	Channel, cation; Membrane protein, integral; Membrane protein, multi-pass	P78348	41	ASIC1	12q12	human	S499	PHOSPHORYLATION	4737851	KRHNPCEsLRGHPAG		activity, inhibited				5930035	1	2	1		
Crk	Adaptor/scaffold; Motility/polarity/chemotaxis	P46108	1398	CRK	17p13.3	human	Y221	PHOSPHORYLATION	447951	GGPEPGPyAQPSVNT		molecular association, regulation	cell adhesion, altered	Arg(INDUCES); RapGEF1(DISRUPTS); Crk(INDUCES); P130Cas(INDUCES); Abl iso2(INDUCES); PXN iso2(DISRUPTS)		5476; 4707; 5486; 3109	19	9	1142		
CDKN2D	Cell cycle regulation; Inhibitor protein	P55273	1032	CDKN2D	19p13	human	S76	PHOSPHORYLATION	6046001	VQDTSGTsPVHDAAR	Ank_2	protein stabilization; ubiquitination; intracellular localization; protein conformation	cell cycle regulation; cell growth, induced			25227666; 5930019	2	1	0	DNA damaged induced nuclear translocation; S76/T141 phosphorylation is necessary for CDKN2D function in DNA repair.; in vitro experiments	
Rb	Nuclear receptor co-regulator; Transcription, coactivator/corepressor; Tumor suppressor	P13405	19645	Rb1		mouse	T819	PHOSPHORYLATION	447984	LPTPTKMtPRSRILV	Rb_C	molecular association, regulation		E2F1(DISRUPTS)		1258	12	18	51		
H1F1	DNA binding protein	Q02539	3024	HIST1H1A	6p21.3	human	S183	PHOSPHORYLATION	15605000	KPKKVAKsPAKAKAV	Ald_Xan_dh_C2		transcription, altered			15562512	1	0	0		
CAMKK1	EC 2.7.11.17; KINASE; Kinase, protein; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor)	Q8N5S9	84254	CAMKK1	17p13.2	human	T108	PHOSPHORYLATION	452083	PRAWRRPtIESHHVA		enzymatic activity, inhibited; enzymatic activity, induced				2852658	6	0	0	activity toward PKIV peptide; activity towards CAMK4.	
LRP6	Membrane protein, integral; Receptor, misc.	O75581	4040	LRP6	12p13.2	human	T1479	PHOSPHORYLATION	457635	SSSSTKGtYFPAILN		activity, induced; molecular association, regulation		axin 1(INDUCES)		11748; 7266	4	1	1		
NSUN2	EC 2.1.1.-; EC 2.1.1.203; EC 2.1.1.29; Methyltransferase	Q08J23	54888	NSUN2	5p15.31	human	S139	PHOSPHORYLATION	478355	SRKILRKsPHLEKFH		molecular association, regulation; intracellular localization; enzymatic activity, inhibited		NPM1(DISRUPTS); NCL(INDUCES)		9566	1	0	0	S139E mutant associates with nucleolin (but not with NPM1);  ; reduced in nocodazole-treated cells;  S139A mutant (but not S139E mutant) associates with NPM1 (but not with nucleolin) in mitotic cells;  phosphorylation of NSUN2 S139 induces dissociation of NPM1 from the NSUN2/nucleolin complex	
SRC-3	ACETYLTRANSFERASE; Acetyltransferase; EC 2.3.1.48; Motility/polarity/chemotaxis; Nuclear receptor co-regulator; Transcription, coactivator/corepressor	Q9Y6Q9	8202	NCOA3	20q12	human	K619	ACETYLATION	460609	PLESKGHkKLLQLLT	SRC-1	molecular association, regulation	transcription, inhibited	ER-alpha(DISRUPTS)		7504	1	0	0		
p53	Activator protein; DNA binding protein; Motility/polarity/chemotaxis; Nuclear receptor co-regulator; Transcription factor; Tumor suppressor	P02340	22059	Tp53		mouse	K364	UBIQUITINATION	464661	RAHSSYLkTKKGQST			transcription, altered			3141407	9	0	0	p53K6R (K378/383/369/379/367/370/R) mutant is still ubiquitinated and shows normal stability of p53 before and after DNA damage	
PAK1	EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, STE; Protein kinase, Ser/Thr (non-receptor)	O88643	18479	Pak1		mouse	T423	PHOSPHORYLATION	448177	PEQSKRStMVGTPYW	Pkinase	enzymatic activity, induced				6385	24	2	9		
Ret	EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Protein kinase, TK; Protein kinase, tyrosine (receptor)	P07949	5979	RET	10q11.2	human	Y864	PHOSPHORYLATION	447626	QISQGMQyLAEMKLV	Pkinase_Tyr	enzymatic activity, induced	cell growth, altered			1261	1	0	0		
ITGB2	Cell adhesion; Cell surface; Membrane protein, integral; Motility/polarity/chemotaxis; Receptor, misc.	P05107	3689	ITGB2	21q22.3	human	T758	PHOSPHORYLATION	448533	NPLFKSAtTTVMNPK	Integrin_b_cyt	molecular association, regulation	cytoskeletal reorganization; cell adhesion, altered	14-3-3 beta(INDUCES); FLNA(DISRUPTS); 14-3-3 zeta(INDUCES); kindlin-3(INDUCES)		4313618; 8580; 9120; 831; 28722117	6	2	4		
Cdc25B	EC 3.1.3.48; Motility/polarity/chemotaxis; Nuclear receptor co-regulator; PHOSPHATASE; Protein phosphatase, dual-specificity	P30305	994	CDC25B	20p13	human	S321	PHOSPHORYLATION	459625	KCQRLFRsPSMPCSV	M-inducer_phosp	molecular association, regulation; intracellular localization; phosphorylation; enzymatic activity, induced		14-3-3 epsilon(DISRUPTS); 14-3-3 beta(DISRUPTS)		15658706	2	1	2	S321 phosphorylation disrupts binding of S323 to 14-3-3, resulting in S323 dephosphorylation	
MDM2	EC 6.3.2.-; EC 6.3.2.19; Inhibitor protein; Ligase; UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase	Q00987	4193	MDM2	12q14.3-q15	human	S17	PHOSPHORYLATION	9184307	TDGAVTTsQIPASEQ		molecular association, regulation; ubiquitination; enzymatic activity, induced		p53(INDUCES)		18021002; 8156702	3	0	0		
MKP-1	EC 3.1.3.16; EC 3.1.3.48; Motility/polarity/chemotaxis; PHOSPHATASE; Protein phosphatase, dual-specificity	P28562	1843	DUSP1	5q34	human	S323	PHOSPHORYLATION	457718	HCSAEAGsPAMAVLD		protein degradation; molecular association, regulation		SKP2(INDUCES)		7315	1	0	0	MKP-1 is a substrate for Skp2 ligase	
Rin1	Guanine nucleotide exchange factor, Rab	Q921Q7	225870	Rin1		mouse	Y35	PHOSPHORYLATION	450778	KPSTDPLyDTPDTRG		molecular association, regulation		Arg(INDUCES)		6201	1	23	1030		
Nur77	Apoptosis; DNA binding protein; Nuclear receptor	P12813	15370	Nr4a1		mouse	S354	PHOSPHORYLATION	447942	GRRGRLPsKPKQPPD		activity, inhibited	transcription, altered			1919607; 1334	7	2	0		
PDE3B	EC 3.1.4.17; Membrane protein, integral; Membrane protein, multi-pass; Nucleotide Metabolism - purine; Phosphodiesterase	Q8CIX5	18576	Pde3b		mouse	S273	PHOSPHORYLATION	447699	VIRPRRRsSCVSLGE		enzymatic activity, induced				1221	2	4	69		
ANPA	EC 4.6.1.2; Guanylyl cyclase; KINASE; Kinase, protein; Lyase; Membrane protein, integral; Nucleotide Metabolism - purine; Protein kinase, RGC; Protein kinase, dual-specificity; Receptor, misc.	P16066	4881	NPR1	1q21-q22	human	S534	PHOSPHORYLATION	447514	AGSRLTLsGRGSNYG		activity, induced				896	2	2	1		
TORC2	Transcription, coactivator/corepressor	Q8BH09	74343	Crtc2		mouse	S70	PHOSPHORYLATION	454630	RSSHYGGsLPNVNQI	TORC_N	molecular association, regulation; intracellular localization	transcription, altered	14-3-3 beta(INDUCES)		6337804	1	13	11		
CCKAR	GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR	P30551	24889	Cckar		rat	S264	PHOSPHORYLATION	451124	FDASQKKsAKEKKPS	7tm_1	receptor desensitization, altered				7712; 3321	2	0	0		
ASK1	EC 2.7.11.25; KINASE; Kinase, protein; Protein kinase, STE; Protein kinase, Ser/Thr (non-receptor)	Q99683	4217	MAP3K5	6q22.33	human	T838	PHOSPHORYLATION	448394	GINPCTEtFTGTLQY	Pkinase	molecular association, regulation; enzymatic activity, induced	apoptosis, altered; transcription, altered	TXN(DISRUPTS); 14-3-3 beta(DISRUPTS)		1163000; 970044	13	1	1		
STAT5B	DNA binding protein; Transcription factor	P51692	6777	STAT5B	17q11.2	human	Y740	PHOSPHORYLATION	448735	AVCPQAHyNMYPQNP		activity, inhibited	transcription, altered; transcription, inhibited			9052; 1172807	3	0	0	transcriptional activation of STAT5B Y740/743 mutant requires phosphorylation of S731 and Y699	
Rb-like 2	Transcription, coactivator/corepressor	Q08999	5934	RBL2	16q12.2	human	T417	PHOSPHORYLATION	449725	KENSPCVtPVSTATH	RB_A	molecular association, regulation	cell cycle regulation	E2F4(DISRUPTS)		1200	2	6	2		
ZO1	Adaptor/scaffold; Motility/polarity/chemotaxis	P39447	21872	Tjp1		mouse	S168	PHOSPHORYLATION	470469	ASRERSLsPRSDRRS			cytoskeletal reorganization			28722435	2	9	10	necessary for cytokinesis	
axin 1	Adaptor/scaffold	O70239	79257	Axin1		rat	S317	PHOSPHORYLATION	2226504	YALAPATsANDSEQQ			cytoskeletal reorganization			25797201	1	0	0	Phosphorylation regulates responsive to Sema3A induced growth cone collapse.	
PAK6	EC 2.7.11.1; KINASE; Kinase, protein; Nuclear receptor co-regulator; Protein kinase, STE; Protein kinase, Ser/Thr (non-receptor)	Q9NQU5	56924	PAK6	15q14	human	S560	PHOSPHORYLATION	450316	KDVPKRKsLVGTPYW	Pkinase	enzymatic activity, induced				4293	2	8	28		
SSTR2	GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR	P30875	20606	Sstr2		mouse	Y228	PHOSPHORYLATION	450819	LTIICLCyLFIIIKV	7tm_1; DUF4117; TM	molecular association, regulation		SHP-2(INDUCES)		3042	1	0	0		
DYN2	EC 3.6.5.5; Hydrolase; Microtubule binding protein; Motility/polarity/chemotaxis; Vesicle protein	P39054	13430	Dnm2		mouse	Y231	PHOSPHORYLATION	451199	LLPLRRGyIGVVNRS	Dynamin_M		cytoskeletal reorganization			20834132	3	1	0	promotes focal adhesion turnover	
GIRK1	Channel, potassium; Membrane protein, integral; Membrane protein, multi-pass	NP_113798	50599	Kcnj3		rat	T407	PHOSPHORYLATION	10769101	PSKLQKItGREDFPK		activity, induced				10425119	2	0	0		
MYPT1	Motility/polarity/chemotaxis; Protein phosphatase, regulatory subunit	O14974	4659	PPP1R12A	12q15-q21	human	S472	PHOSPHORYLATION	452042	AGVTRSAsSPRLSSS		molecular association, regulation	cell adhesion, altered	14-3-3 beta(INDUCES)		14148621	1	4	40		
PIAS1	EC 6.3.2.-; Nuclear receptor co-regulator; SUMO LIGASE; SUMO conjugating system; Transcription, coactivator/corepressor	O88907	56469	Pias1		mouse	S90	PHOSPHORYLATION	479880	SPMPPTLsPSTIPQL			transcription, inhibited			11506	1	1	0	 ; phosphorylation of this site inhibits TNF-induced expression of NFKB-target genes and IFN-induced expression of STAT1-target genes	
TP2	DNA binding protein	P11101	24840	Tnp2		rat	S109	PHOSPHORYLATION	450902	HRAKRRSsGRRYK__	TP2; YL1; MoCo_carrier	intracellular localization				3047	1	0	0		
TAL1	DNA binding protein; Transcription factor	P22091	21349	Tal1		mouse	S172	PHOSPHORYLATION	4704529	NRVKRRPsPYEMEIS		molecular association, regulation			DNA(DISRUPTS)	10144211	2	2	1		
LKB1	Autophagy; EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, CAMK; Protein kinase, Ser/Thr (non-receptor)	Q9WTK7	20869	Stk11		mouse	T336	PHOSPHORYLATION	448150	KDRWRSMtVVPYLED		activity, inhibited	cell growth, altered			1155	2	0	0		
IGF1R	EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Protein kinase, TK; Protein kinase, tyrosine (receptor)	P08069	3480	IGF1R	15q26.3	human	S1310	PHOSPHORYLATION	2091903	VPLDPSAsSSSLPLP		activity, induced; phosphorylation	apoptosis, altered; cell differentiation, altered; cell growth, altered			2703; 2727	2	0	0	observed in Y980F +  S1310-1313A; ERK phosphorylation	
ataxin-1	RNA binding protein	P54254	20238	Atxn1		mouse	S751	PHOSPHORYLATION	449110	ATRKRRWsAPETRKL			apoptosis, altered			15562531	11	15	3	S776D mutation initiates neuronal death	
GluR2	Channel, calcium; Channel, ligand-gated; Membrane protein, integral; Membrane protein, multi-pass	P23819	14800	Gria2		mouse	S880	PHOSPHORYLATION	448351	YNVYGIEsVKI____		receptor internalization, altered				7613731	20	1	0		
NDEL1	Microtubule binding protein; Protease	Q9ERR1	83431	Ndel1		mouse	S231	PHOSPHORYLATION	474507	GTENSFPsPKAIPNG	NUDE_C	activity, induced; intracellular localization	cell motility, altered			2425202	4	9	0	Cdc42 activation	
p70S6K	EC 2.7.11.-; EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor); Translation	P23443	6198	RPS6KB1	17q23.1	human	T412	PHOSPHORYLATION	448607	NQVFLGFtYVAPSVL	Pkinase_C	intracellular localization; phosphorylation; enzymatic activity, induced	cell cycle regulation; translation, altered; cell adhesion, altered			5984; 7124723; 5708; 2563; 4719; 5820; 2561; 2732; 5011213; 4759; 5285; 11751; 2962; 2745103	301	1	1		
CBP	ACETYLTRANSFERASE; Acetyltransferase; DNA binding protein; EC 2.3.1.48; Motility/polarity/chemotaxis; Nuclear receptor co-regulator; Transcription, coactivator/corepressor	P45481	12914	Crebbp		mouse	S301	PHOSPHORYLATION	448068	PQLASKQsMVNSLPA			transcription, induced			1333	1	0	0		
TGFBR2	EC 2.7.11.30; KINASE; Kinase, protein; Membrane protein, integral; Protein kinase, Ser/Thr (receptor); Protein kinase, TKL	P37173	7048	TGFBR2	3p22	human	S213	PHOSPHORYLATION	452047	TRKLMEFsEHCAIIL			cell growth, altered			3992	1	0	0		
MTHFR	Cofactor and Vitamin Metabolism - one carbon pool by folate; EC 1.5.1.20; Energy Metabolism - methane; Oxidoreductase	P42898	4524	MTHFR	1p36.3	human	T34	PHOSPHORYLATION	456129	KDSSRCStPGLDPER		enzymatic activity, inhibited				6633	1	1	2		
FLT3	EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Protein kinase, TK; Protein kinase, tyrosine (receptor)	P36888	2322	FLT3	13q12	human	Y597	PHOSPHORYLATION	450033	FYVDFREyEYDLKWE		phosphorylation				2594	2	0	0	 however, in the FLT3-ITD mutant,  there is only a slight decrease in its phosphotyrosine content and this mutation does not alter its transforming capabilities (and STAT5a and MAPK activation and SHC phosphorylation).; Mutation of all 4 sites from Y->F abrogates the phosphotyrosine content of wt-FLT3	
HSP90B	Chaperone	P08238	3326	HSP90AB1	6p12	human	Y301	PHOSPHORYLATION	462282	DDITQEEyGEFYKSL	HSP90	molecular association, regulation		eNOS(INDUCES)		762724	1	0	8	promotes NO(2-) release	
NCAM-L1	Cell adhesion; Membrane protein, integral	P32004	3897	L1CAM	Xq28	human	Y1229	PHOSPHORYLATION	10272401	DGSFIGQySGKKEKE	Bravo_FIGEY	protein conformation; phosphorylation				9985921	3	0	4	mutation of this site promotes phosphorylation of N-CAML1  Y1151, Y1176, Y1211 and T1172	
MCL1	Apoptosis; Channel, misc.; Inhibitor protein; Membrane protein, integral; Mitochondrial	Q07820	4170	MCL1	1q21	human	S64	PHOSPHORYLATION	479431	IGGSAGAsPPSTLTP		molecular association, regulation	apoptosis, inhibited	Bim(INDUCES); NOXA1(INDUCES)		11476	4	3	0		
VAV1	Guanine nucleotide exchange factor, Rac/Rho; Motility/polarity/chemotaxis	P15498	7409	VAV1	19p13.2	human	Y174	PHOSPHORYLATION	447866	EAEGDEIyEDLMRSE		molecular association, regulation; intracellular localization; activity, inhibited	cell differentiation, altered; transcription, inhibited; cell growth, altered	PLCG1(INDUCES); Lck(INDUCES); PIK3R1(INDUCES)		1308; 2587209	12	0	0		
WAVE1	Cytoskeletal protein; Motility/polarity/chemotaxis	Q5BJU7		Wasf1		rat	S397	PHOSPHORYLATION	7979603	APPLVQPsPPVARAA		intracellular localization	cytoskeletal reorganization			7910501	2	1	0		
Rab11FIP2	Cytoskeletal protein	Q7L804	22841	RAB11FIP2	10q26.11	human	S227	PHOSPHORYLATION	465674	QRLSSAHsMSDLSGS			cytoskeletal reorganization			8087	2	4	0	important for formation of junctional complexes and cell polarity	
raptor	Adaptor/scaffold	Q8N122	57521	RPTOR	17q25.3	human	S771	PHOSPHORYLATION	13251700	SASSTLGsPENEEHI		activity, induced				22343619	2	1	0	mTORC1 activation	
E2A	DNA binding protein; Transcription factor	P15923	6929	TCF3	19p13.3	human	T355	PHOSPHORYLATION	455166	NFSSSPStPVGSPQG		activity, inhibited	transcription, inhibited			10353939	3	2	21		
HEC1	Cell cycle regulation	O14777	10403	NDC80	18p11.32	human	S15	PHOSPHORYLATION	474511	SGGAGRLsMQELRSQ			cell cycle regulation			9229	1	0	0	mutation of six N-terminal residues (S5,S15,S44,T49,S55 and S69) to alanines interferes with mitosis	
SLAM	Membrane protein, integral; Receptor, misc.	Q13291	6504	SLAMF1	1q23.3	human	Y281	PHOSPHORYLATION	447633	EKKSLTIyAQVQKPG		molecular association, regulation		SHP-2(INDUCES); APCS(INDUCES)		1383	2	4	757		
ITGB1	Cell adhesion; Cell surface; Membrane protein, integral; Motility/polarity/chemotaxis; Receptor, misc.	P09055	16412	Itgb1		mouse	Y795	PHOSPHORYLATION	447711	TTVVNPKyEGK____	Integrin_b_cyt		cell motility, altered; cell adhesion, altered			2701; 1686	6	10	223		
AQP2	Channel, misc.; Membrane protein, integral; Membrane protein, multi-pass	P56402	11827	Aqp2		mouse	S264	PHOSPHORYLATION	2238600	VELHSPQsLPRGSKA		intracellular localization				12728102	9	6	0	plasma membrane abundance	
Pim1	EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, CAMK; Protein kinase, Ser/Thr (non-receptor)	P06803	18712	Pim1		mouse	Y302	PHOSPHORYLATION	451014	EWIRYHRyHGRSAAV	Pkinase	activity, induced				3264	1	0	0		
IBTK	Protein kinase, regulatory subunit	Q9P2D0	25998	IBTK	6q14.1	human	S1200	PHOSPHORYLATION	21358401	ASSLHSVsSKSFRDF		molecular association, regulation		Btk(DISRUPTS)		21356308	1	0	0	regulation of the Btk:IBTK complex	
GTF2A1	Transcription, coactivator/corepressor	P52655	2957	GTF2A1	14q31.1	human	S316	PHOSPHORYLATION	448629	VEEEPLNsEDDVSDE	TFIIA; Syndecan		transcription, induced			1829	1	1	0		
NOXA1	Activator protein	Q86UR1	10811	NOXA1	9q34.3	human	S172	PHOSPHORYLATION	990300	DQVQRRGsLPPRQVP		molecular association, regulation		RAC1(DISRUPTS); NOX1(DISRUPTS)		12558706	2	0	0	prevents hyperactivation of NOX1	
LRP2	Membrane protein, integral; Motility/polarity/chemotaxis; Receptor, misc.	P98164	4036	LRP2	2q31.1	human	T4641	PHOSPHORYLATION	767907	TYSATEDtFKDTANL		receptor internalization, altered; receptor recycling, altered				762703	1	0	1		
MKP-3	EC 3.1.3.16; EC 3.1.3.48; Motility/polarity/chemotaxis; Protein phosphatase, dual-specificity	Q16828	1848	DUSP6	12q22-q23	human	S197	PHOSPHORYLATION	455266	SATDSDGsPLSNSQP		protein degradation				4429	4	0	0		
CACNG2	Channel, calcium; Membrane protein, integral; Membrane protein, multi-pass	O88602	12300	Cacng2		mouse	S239	PHOSPHORYLATION	455315	RYQRRSRsSSRSTEP	Tetraspannin	activity, induced; intracellular localization				22913905; 4485	1	0	0	AMPAR immobilization in synaptic membrane; enhances AMPA receptor responses and is required for long-term potentiation	
CIITA	DNA binding protein; Transcription, coactivator/corepressor	P33076	4261	CIITA	16p13	human	S280	PHOSPHORYLATION	471421	TVHGLPTsPDRPGST		protein degradation; molecular association, regulation	transcription, induced	CCNT1(INDUCES)		9083	2	0	0		
MAP1B	Cytoskeletal protein; Motility/polarity/chemotaxis	P14873	17755	Map1b		mouse	T1265	PHOSPHORYLATION	455476	PPSPIEKtPLGERSV			cytoskeletal reorganization			5211	2	2	3	induces a loss of stable microtubules	
MRE11A	Cell cycle regulation; DNA binding protein; DNA repair; Deoxyribonuclease	P49959	4361	MRE11A	11q21	human	S678	PHOSPHORYLATION	460789	SSKIMSQsQVSKGVD		molecular association, regulation			DNA(DISRUPTS)	11484420	1	2	5		
LATS2	EC 2.7.11.1; KINASE; Kinase, protein; Nuclear receptor co-regulator; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor)	Q9NRM7	26524	LATS2	13q11-q12	human	S83	PHOSPHORYLATION	451703	ALREIRYsLLPFANE		intracellular localization				3816	4	0	0		
PPP2R5D	Motility/polarity/chemotaxis; Protein phosphatase, regulatory subunit	Q7TNL5	21770	Ppp2r5d		mouse	S68	PHOSPHORYLATION	457389	QLSKIKYsGGPQIVK		enzymatic activity, induced				12778805	4	1	0		
CD4	Cell surface; Membrane protein, integral	P01730	920	CD4	12p13.31	human	S440	PHOSPHORYLATION	469618	SQIKRLLsEKKTCQC	Herpes_gE; Tcell_CD4_Cterm	intracellular localization				8363	1	0	0		
Nlp	Cell cycle regulation; Microtubule binding protein	Q9Y2I6	22981	NINL	20p11.22-p11.1	human	S589	PHOSPHORYLATION	17490600	NRHSPSWsPDGRRRQ		protein degradation; ubiquitination; intracellular localization				17482929	1	0	0		
GCM1	DNA binding protein; Transcription factor	Q9NP62	8521	GCM1	6p12.1	human	S326	PHOSPHORYLATION	7979601	PLTSWPCsFSPSQNS		protein degradation; molecular association, regulation; ubiquitination		FBXW2(INDUCES)		7889912	1	0	0		
SLC6A1	Membrane protein, integral; Membrane protein, multi-pass; Transporter	P30531	6529	SLC6A1	3p25.3	human	Y317	PHOSPHORYLATION	11382800	NSFHNNVyRDSIIVC	SNF	activity, induced; receptor internalization, altered; intracellular localization				10292914	1	0	0		
WAVE1	Cytoskeletal protein; Motility/polarity/chemotaxis	Q8R5H6	83767	Wasf1		mouse	S397	PHOSPHORYLATION	7979603	APPLVQPsPPVARAA		activity, inhibited				14081210	2	1	0		
Dok2	Adaptor/scaffold	O70469	13449	Dok2		mouse	Y402	PHOSPHORYLATION	455779	DWPQATEyDNVILKK		molecular association, regulation	apoptosis, induced	CSK(INDUCES)		5809	1	0	41	Dok2 constitutively interacts with Src.  Induced binding of Csk to Dok2 allows Csk to act on Src.	
PAH	Amino Acid Metabolism - phenylalanine, tyrosine and tryptophan biosynthesis; EC 1.14.16.1; Oxidoreductase	P04176	24616	Pah		rat	S16	PHOSPHORYLATION	449074	GVLSRKLsDFGQETS		protein conformation				8715	6	4	36		
Notch 1	Membrane protein, integral; Motility/polarity/chemotaxis; Receptor, misc.; Transcription factor	P46531	4851	NOTCH1	9q34.3	human	S2522	PHOSPHORYLATION	467288	ESPDQWSsSSPHSNV	DUF3454	protein degradation; receptor inactivation, altered				8231	1	0	0	Alanine mutation of 4 serines (S2522/S2523/S2524/S2525) causes increased protein stability.	
ID3	DNA binding protein; Transcription, coactivator/corepressor	Q02535	3399	ID3	1p36.13-p36.12	human	S5	PHOSPHORYLATION	451011	___MKALsPVRGCYE			cell cycle regulation; transcription, altered			3261	1	0	9	Cdk-dependent phosphorylation inactivates the G1-to-S cell cycle regulatory function of Id3 protein.	
EphA3	EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Protein kinase, TK; Protein kinase, tyrosine (receptor)	P29320	2042	EPHA3	3p11.2	human	Y596	PHOSPHORYLATION	449912	KLPGLRTyVDPHTYE		molecular association, regulation; protein conformation; enzymatic activity, induced	cytoskeletal reorganization; cell adhesion, altered	Crk(INDUCES)		25779406; 2462	3	6	39		
ACC1	Carbohydrate Metabolism - propanoate; Carbohydrate Metabolism - pyruvate; EC 6.3.4.14; EC 6.4.1.2; Ligase; Lipid Metabolism - fatty acid biosynthesis	P11497	60581	Acaca		rat	S79	PHOSPHORYLATION	448292	FHMRSSMsGLHLVKQ		enzymatic activity, inhibited				824; 905; 2742; 1937	90	34	10		
axin 1	Adaptor/scaffold	O15169	8312	AXIN1	16p13.3	human	S469	PHOSPHORYLATION	25802104	AHEENPEsILDEHVQ	Axin_b-cat_bind		transcription, inhibited	GSK3B(INDUCES)		25785410	1	2	0		
p57Kip2	Inhibitor protein; Nuclear receptor co-regulator	P49918	1028	CDKN1C	11p15.5	human	S282	PHOSPHORYLATION	9318134	FFAKRKRsAPEKSSG		protein degradation				27623409	1	0	0	DN-Akt stabilized p57	
ITGB7	Cell adhesion; Membrane protein, integral; Motility/polarity/chemotaxis; Receptor, misc.	P26010	3695	ITGB7	12q13.13	human	T785	PHOSPHORYLATION	464649	YKSAITTtINPRFQE	Integrin_b_cyt	molecular association, regulation		FLNA(DISRUPTS)		7907	1	0	0	based on glutamate mutant of threonine site	
SIRT1	Apoptosis; DEACETYLASE; Deacetylase; EC 3.5.1.-; Nuclear receptor co-regulator	Q923E4	93759	Sirt1		mouse	S649	PHOSPHORYLATION	6855923	FHGAEVYsDSEDDVL		enzymatic activity, induced	apoptosis, inhibited			9980406	2	0	0	deacetylates p53 K382 and NFkB-p65	
NR2C2	DNA binding protein; Nuclear receptor; Transcription factor	P49117	22026	Nr2c2		mouse	S68	PHOSPHORYLATION	467310	TGKVILAsPETSSAK		activity, inhibited	transcription, altered			8254	1	4	0		
TIM-3	Membrane protein, integral; Receptor, misc.	Q8VIM0	171285	Havcr2		mouse	Y263	PHOSPHORYLATION	26371002	YTIEENVyEVENSNE		molecular association, regulation		BAT3(DISRUPTS)		26341713	1	0	0		
AQP4	Channel, misc.; Membrane protein, integral; Membrane protein, multi-pass	P55087	361	AQP4	18q11.2-q12.1	human	S180	PHOSPHORYLATION	467301	TIFASCDsKRTDVTG	MIP	activity, inhibited	cell motility, altered			10425116	4	0	0	 mutation of this site (S180A) increases invasion of tumor cells; reduces water permeability	
RXRA	DNA binding protein; Motility/polarity/chemotaxis; Nuclear receptor	P28700	20181	Rxra		mouse	S22	PHOSPHORYLATION	453093	VNSSSLNsPTGRGSM	Nuc_recep-AF1		cell cycle regulation; transcription, altered; cell growth, altered			8792	2	5	4		
eNOS	Amino Acid Metabolism - arginine and proline; EC 1.14.13.39; Oxidoreductase	P29473	287024	NOS3		cow	S617	PHOSPHORYLATION	448656	SYKIRFNsVSCSDPL	Flavodoxin_1	molecular association, regulation; enzymatic activity, induced; phosphorylation		HSP90A(DISRUPTS); Akt1(DISRUPTS)		9401416; 3256102; 5695	10	3	0		
S100A9	Calcium-binding protein	P06702	6280	S100A9	1q21	human	T113	PHOSPHORYLATION	455888	KPGLGEGtP______		activity, induced; intracellular localization	cytoskeletal reorganization			11454; 6365	4	8	22		
SH3BP2	Adaptor/scaffold	P78314	6452	SH3BP2	4p16.3	human	Y448	PHOSPHORYLATION	449093	GDDSDEDyEKVPLPN		molecular association, regulation	transcription, altered	Lck(INDUCES)		5235	4	0	0		
Rb	Nuclear receptor co-regulator; Transcription, coactivator/corepressor; Tumor suppressor	P33568	24708	Rb1		rat	S787	PHOSPHORYLATION	447979	SPYKFSSsPLRIPGG	Rb_C	molecular association, regulation	transcription, inhibited	HDAC1(INDUCES)		7119507	34	9	87		
ADCY6	Adenylyl cyclase; EC 4.6.1.1; Lyase; Membrane protein, integral; Membrane protein, multi-pass; Nucleotide Metabolism - purine	AAA40678	25289	Adcy6		rat	S10	PHOSPHORYLATION	450817	LPVARSGsGRSSMSW		enzymatic activity, inhibited				3690	2	0	0		
CD28	Cell surface; Membrane protein, integral	P31041	12487	Cd28		mouse	Y207	PHOSPHORYLATION	450284	TRKPYQPyAPARDFA		activity, induced				3934	4	5	288	Y207F mutation severely impaired the ability of CD28 to deliver a co-stimulus for the expression of CD69 and production of IL-2.	
TRPC3	Channel, cation; Membrane protein, integral; Membrane protein, multi-pass	Q13507	7222	TRPC3		human	Y214	PHOSPHORYLATION	458805	KGLASPAyLSLSSED		activity, induced				7468	1	0	0		
InsR	EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Protein kinase, TK; Protein kinase, tyrosine (receptor)	P06213	3643	INSR	19p13.3-p13.2	human	S1062	PHOSPHORYLATION	451562	AVKTVNEsASLRERI	Pkinase_Tyr	phosphorylation				8570	2	0	1	alanine mutations of S1033, S1062, and S1064 increases tyrosine autophosphorylation of InsR	
emerin	Cytoskeletal protein; Membrane protein, integral	P50402	2010	EMD	Xq28	human	Y161	PHOSPHORYLATION	449652	MYGRDSAyQSITHYR	PknH_C	molecular association, regulation		BAF(INDUCES)		10425105	1	7	223		
NFAT3	DNA binding protein; Transcription factor	Q14934	4776	NFATC4	14q11.2	human	S168	PHOSPHORYLATION	448859	QGGGAFFsPSPGSSS		intracellular localization; activity, inhibited	cell differentiation, altered; transcription, altered; cell growth, altered			2030; 12482414	5	0	1		
YB-1	RNA processing; RNA splicing; Transcription factor	P67809	4904	YBX1	1p34	human	S102	PHOSPHORYLATION	455636	NPRKYLRsVGDGETV	CSD	activity, induced; intracellular localization	carcinogenesis, altered; transcription, altered; cell growth, altered			5503; 6702325; 15562516	4	12	2	suppresses the growth of cancer cells	
MELK	EC 2.7.10.2; EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, CAMK; Protein kinase, Ser/Thr (non-receptor); RNA splicing	Q14680	9833	MELK	9p13.2	human	T167	PHOSPHORYLATION	456039	NKDYHLQtCCGSLAY	Pkinase	enzymatic activity, induced				2852669	2	1	0		
MDM2	EC 6.3.2.-; EC 6.3.2.19; Inhibitor protein; Ligase; UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase	Q00987	4193	MDM2	12q14.3-q15	human	S186	PHOSPHORYLATION	448131	RQRKRHKsDSISLSF		activity, induced; protein stabilization; molecular association, regulation; ubiquitination; intracellular localization	apoptosis, altered	ARF1(INDUCES); p300(INDUCES)		5974; 4313601; 6268; 2337	10	5	1		
CDK11B iso12	Apoptosis; EC 2.7.11.22; KINASE; Kinase, protein; Motility/polarity/chemotaxis; Protein kinase, CMGC; Protein kinase, Ser/Thr (non-receptor)	P21127-12	984	CDK11B	1p36.33	human	T370	PHOSPHORYLATION	17671300	KHEYFREtPLPIDPS		molecular association, regulation; enzymatic activity, induced	apoptosis, altered	CDK11A iso10(INDUCES)		17431537	1	0	0	T370A mutant fails to repress the transactivation of androgen receptor and to enhance the cell apoptosis	
PDE4D iso5	EC 3.1.4.17; Nucleotide Metabolism - purine; Phosphodiesterase	Q08499-5	5144	PDE4D	5q12	human	S413	PHOSPHORYLATION	451090	YQSTIPQsPSPAPDD		enzymatic activity, inhibited				3199	4	2	0		
RPT6	Nuclear receptor co-regulator; Proteasome complex; Ubiquitin conjugating system	P62195	5705	PSMC5	17q23.3	human	S120	PHOSPHORYLATION	483970	RVALRNDsYTLHKIL		activity, induced				11953	6	1	0	S120A mutation blocks proteasome function in vivo	
NFkB-p65	DNA binding protein; Nuclear receptor co-regulator; Transcription factor	NP_954888	309165	Rela		rat	S276	PHOSPHORYLATION	447798	SMQLRRPsDRELSEP			cell differentiation, altered; transcription, induced			4260508	62	0	0	nerve myelination	
PKCD	EC 2.7.10.2; EC 2.7.11.13; KINASE; Kinase, protein; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor)	Q05655	5580	PRKCD	3p21.31	human	Y313	PHOSPHORYLATION	447573	SSEPVGIyQGFEKKT		phosphorylation	apoptosis, altered; transcription, inhibited			3309902; 2624105	28	37	1723		
AR	DNA binding protein; Nuclear receptor; Transcription factor	P10275	367	AR	Xq12	human	Y267	PHOSPHORYLATION	478250	QLRGDCMyAPLLGVP	Androgen_recep	molecular association, regulation	transcription, induced; cell growth, altered		DNA(INDUCES)	11423; 15020910	3	2	0	inhibited by AR-100 	
Tiam1	Guanine nucleotide exchange factor, Rac/Rho; Motility/polarity/chemotaxis	Q60610	21844	Tiam1		mouse	S172	PHOSPHORYLATION	11485306	FKKKRSKsADIWRED		molecular association, regulation		14-3-3 zeta(INDUCES)		11419330	1	2	0		
PDGFRB	EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Protein kinase, TK; Protein kinase, tyrosine (receptor)	P09619	5159	PDGFRB	5q33.1	human	Y740	PHOSPHORYLATION	447520	TGESDGGyMDMSKDE	Pkinase_Tyr	activity, induced; molecular association, regulation; enzymatic activity, induced	cell cycle regulation	Shc1(INDUCES); PIK3C2A(INDUCES); PIK3R1(INDUCES); PIK3CA(INDUCES)		2280; 1173023; 1230; 7991117; 7324108; 3825; 1843	10	1	7		
HIPK2	EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, CMGC; Protein kinase, Ser/Thr (non-receptor)	Q9H2X6	28996	HIPK2	7q32-q34	human	K803	UBIQUITINATION	3059905	TSTTSSRkSKQHQSS		protein degradation				2831762	1	0	0		
XRCC1	DNA repair	P18887	7515	XRCC1	19q13.2	human	T523	PHOSPHORYLATION	451448	AGSTDENtDSEEHQE		molecular association, regulation; intracellular localization		APTX(INDUCES); Pnk1(INDUCES)		3651; 8895	2	3	3		
MSK2	EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor)	O75676	8986	RPS6KA4	11q11-q13	human	T568	PHOSPHORYLATION	450047	SPGVPMQtPCFTLQY	Pkinase	enzymatic activity, induced				1264	1	0	0		
Ctip	EC 3.1.-.-; Transcription, coactivator/corepressor	Q99708	5932	RBBP8	18q11.2	human	S327	PHOSPHORYLATION	452473	ELPTRVSsPVFGATS		molecular association, regulation	cell cycle regulation	BRCA1(INDUCES)		6677; 6820	1	8	1	Phosphorylation required for G2/M transition checkpoint.	
MED1	Nuclear receptor co-regulator; Transcription, coactivator/corepressor	Q925J9	19014	Med1		mouse	T1459	PHOSPHORYLATION	449866	HSKSPAYtPQNVDSE			transcription, induced			2425236	4	1	0		
PEDF	Inhibitor protein; Secreted; Secreted, signal peptide	P36955	5176	SERPINF1	17p13.3	human	S227	PHOSPHORYLATION	455233	KFDSRKTsLEDFYLD	Serpin	molecular association, regulation	apoptosis, altered; carcinogenesis, altered; cell motility, altered	LEPR(INDUCES)		18410809	3	1	0		
NFAT1	DNA binding protein; Transcription factor	Q60591	18019	Nfatc2		mouse	S99	PHOSPHORYLATION	447854	IGFQNFLsPVKPAGA			transcription, inhibited			1188	0	1	1		
eIF4G3	Translation; Translation initiation	O43432	8672	EIF4G3	1p36.12	human	S1156	PHOSPHORYLATION	2915400	NTFMRGGsSKDLLDN		molecular association, regulation	translation, induced	eIF4E(INDUCES)		25227649	2	2	0		
Btk	EC 2.7.10.2; KINASE; Kinase, protein; Protein kinase, TK; Protein kinase, tyrosine (non-receptor)	P35991	12229	Btk		mouse	S21	PHOSPHORYLATION	463806	SQQKKKTsPLNFKKR	PH	molecular association, regulation		Pin1(INDUCES)		7851	1	1	2	Interaction with Pin1 negatively regulates Btk expression.	
PZR	Adaptor/scaffold; Membrane protein, integral	O95297	9019	MPZL1	1q24.2	human	Y263	PHOSPHORYLATION	449521	NKSESVVyADIRKN_	Myelin-PO_C	molecular association, regulation	cell adhesion, altered	SHP-2(INDUCES)		3491	1	27	1073		
MEK1	EC 2.7.12.2; KINASE; Kinase, protein; Protein kinase, STE; Protein kinase, dual-specificity	Q02750	5604	MAP2K1	15q22.1-q22.33	human	S222	PHOSPHORYLATION	448513	LIDSMANsFVGTRSY	Pkinase	enzymatic activity, induced	cell cycle regulation; cell growth, altered			5708; 5672; 7324124; 6047; 1740; 3342623; 5930044; 7839	85	9	183		
tau iso8	Cytoskeletal protein	P10636-8	4137	MAPT	17q21.1	human	S262	PHOSPHORYLATION	447930	NVKSKIGsTENLKHQ	Tubulin-binding	O-GlcNAc glycosylation; molecular association, regulation; protein stabilization; protein conformation; phosphorylation	apoptosis, altered; apoptosis, induced; cytoskeletal reorganization	TUBA4A(DISRUPTS); TUBA1A(DISRUPTS); TUBB(DISRUPTS); TUBA1A(INDUCES)		14821625; 4420; 8165400; 15754007; 4418; 2587206; 8985; 2704327; 19084437; 10303912; 15331007	68	8	2	critical for  A-beta42-induced tau toxicity; induced  tau-tau association and formed aggregates in cell nucleus; S262 phosphorylation induces tau toxicity in the drosophila eye	
TH	Amino Acid Metabolism - tyrosine; EC 1.14.16.2; Endoplasmic reticulum; Mitochondrial; Oxidoreductase; Vesicle protein	P24529	21823	Th		mouse	S19	PHOSPHORYLATION	448542	KGFRRAVsEQDTKQA	TOH_N; Chorion_2	phosphorylation				22879422	33	4	3	SNCA S129A mutant has higher PPP2CA activation inhibiting TH S19 phosphorylation. 	
FLOT1	Adaptor/scaffold	O75955	10211	FLOT1	6p21.3	human	Y160	PHOSPHORYLATION	462262	DIHDDQDyLHSLGKA	Band_7		endocytosis, altered			7324301	1	1	48	regulates FLOT1 internalization	
PPAR-alpha	DNA binding protein; Nuclear receptor	Q07869	5465	PPARA	22q13.31	human	S6	PHOSPHORYLATION	1789804	__MVDTEsPLCPLSP			transcription, inhibited			18021032; 1713131	2	0	0		
H1R	GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR	P35367	3269	HRH1	3p25	human	T140	PHOSPHORYLATION	453406	LRYLKYRtKTRASAT	7tm_1	receptor desensitization, altered; receptor internalization, altered				4674; 4121	2	0	0		
HBP1	DNA binding protein; Transcription factor	O60381	26959	HBP1	7q22-q31	human	S402	PHOSPHORYLATION	455671	GFSKNCGsPGSSQLS		protein stabilization				5715	1	0	0		
ADRB2	GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR	P07550	154	ADRB2	5q31-q32	human	S346	PHOSPHORYLATION	447911	LLCLRRSsLKAYGNG		receptor desensitization, altered; receptor internalization, altered				3435; 1642	8	1	0		
IkB-alpha	DNA binding protein; Inhibitor protein	P25963	4792	NFKBIA	14q13	human	S293	PHOSPHORYLATION	451525	EESYDTEsEFTEFTE		protein degradation				8568	3	0	0		
HNF4 alpha	DNA binding protein; Nuclear receptor; Transcription factor	P41235	3172	HNF4A	20q13.12	human	S313	PHOSPHORYLATION	449926	GKIKRLRsQVQVSLE	Hormone_recep	protein degradation	transcription, inhibited			2474	3	1	0		
AMPKA1	Autophagy; EC 2.7.1.-; EC 2.7.11.1; EC 2.7.11.26; KINASE; Kinase, protein; Protein kinase, CAMK; Protein kinase, Ser/Thr (non-receptor)	Q13131	5562	PRKAA1	5p12	human	T183	PHOSPHORYLATION	448786	SDGEFLRtSCGSPNY	Pkinase	intracellular localization; enzymatic activity, induced				5321; 3423; 6881; 9086; 1975; 5576; 22726506; 7709700	154	11	19	AMPKA1 activators increased phosphorylation level and cytoplasmic localization (reduced nuclear/cytoplasmic ratio). AMPKA1 activators reduced RNA synthesis in the nucleoli.	
CTNNB1	Actin binding protein; Cell adhesion; Motility/polarity/chemotaxis; Nuclear receptor co-regulator; Transcription factor	Q9WU82	84353	Ctnnb1		rat	S33	PHOSPHORYLATION	447487	QQQSYLDsGIHSGAT		protein degradation; intracellular localization; phosphorylation	cytoskeletal reorganization			3803; 1173007	51	3	2		
PLCG1	Carbohydrate Metabolism - inositol phosphate; EC 3.1.4.11; Motility/polarity/chemotaxis; Phospholipase	P10686	25738	Plcg1		rat	Y1253	PHOSPHORYLATION	448576	EGSFEARyQQPFEDF		enzymatic activity, induced				760	11	14	50	Y771F mutation completely blocked activation while Y774F enhanced, and Y1253F inhibited full activation. 	
TPPP	Cytoskeletal protein	O94811	11076	TPPP	5p15.3	human	S18	PHOSPHORYLATION	456612	ANRTPPKsPGDPSKD			cytoskeletal reorganization			12255	1	15	9	ERK2 phosphorylation of TPPP induces formation of tubulin assemblies. 	
MYH9	Actin binding protein; Motility/polarity/chemotaxis; Motor protein	P35579	4627	MYH9	22q13.1	human	S1943	PHOSPHORYLATION	456730	RKGAGDGsDEEVDGK		molecular association, regulation; intracellular localization	cell motility, altered; cytoskeletal reorganization	S100A4(DISRUPTS)		11967; 18415120; 25027308; 5007914	6	67	893		
CK1E	EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, CK1; Protein kinase, Ser/Thr (non-receptor)	P49674	1454	CSNK1E	22q13.1	human	S389	PHOSPHORYLATION	482888	RGAPANVsSSDLTGR		protein degradation	transcription, altered			11757	1	8	13	phaosphorylation induces degredation of mPer2 and expression of circadian clock genes.	
Rad9	Apoptosis; Cell cycle regulation; DNA replication; Deoxyribonuclease; EC 3.1.11.2	Q99638	5883	RAD9A	11q13.1-q13.2	human	S341	PHOSPHORYLATION	449817	PKSPGPHsEEEDEAE		molecular association, regulation		TOPBP1(INDUCES)		14790319	3	3	7	important for the DNA damage response (UV and MMS)	
SRC-3	ACETYLTRANSFERASE; Acetyltransferase; EC 2.3.1.48; Motility/polarity/chemotaxis; Nuclear receptor co-regulator; Transcription, coactivator/corepressor	Q9Y6Q9	8202	NCOA3	20q12	human	T1064	PHOSPHORYLATION	4252807	LHTLLSNtDATGLEE	Nuc_rec_co-act	protein stabilization; molecular association, regulation		PSMA3(DISRUPTS)		4248206	1	0	0	some subset of these 8 residues	
SSTR5	Cell cycle regulation; GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR	P35346	6755	SSTR5	16p13.3	human	S242	PHOSPHORYLATION	1779801	VGCVRRRsERKVTRM	7tm_1	activity, induced; molecular association, regulation; receptor internalization, altered		ARRB2(INDUCES)		1713149	1	0	0		
NDR1	EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor)	Q15208	11329	STK38	6p21	human	T444	PHOSPHORYLATION	460659	DWVFINYtYKRFEGL	Pkinase_C	molecular association, regulation; phosphorylation; enzymatic activity, induced	cytoskeletal reorganization	MOB1A(INDUCES); MOB1B(NOT_REPORTED)		25082851; 1998; 12066004	5	2	0	reduction in dendritic branching and length ; NDR1 Y31A and Y74A mutants showed highly decreased T444 phosphorylation and centrosome amplification.	
PAK1	EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, STE; Protein kinase, Ser/Thr (non-receptor)	Q13153	5058	PAK1	11q13-q14	human	S204	PHOSPHORYLATION	448173	TKSVYTRsVIEPLPV		intracellular localization; protein conformation; enzymatic activity, induced	cell motility, altered; cell adhesion, altered			9987305	10	8	0	recruitment to the plasma membrane	
MDM2	EC 6.3.2.-; EC 6.3.2.19; Inhibitor protein; Ligase; UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase	Q00987	4193	MDM2	12q14.3-q15	human	S246	PHOSPHORYLATION	454925	DSVSDQFsVEFEVES		activity, induced				4379	3	0	0	promotes p53 degradation	
NEDD4L	EC 6.3.2.-; EC 6.3.2.19; Ligase; UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase	Q8CFI0	83814	Nedd4l		mouse	S477	PHOSPHORYLATION	453440	IRRPRSLsSPTVTLS		molecular association, regulation		14-3-3 beta(INDUCES)		7847	10	29	50		
STAT5B	DNA binding protein; Transcription factor	P42232	20851	Stat5b		mouse	Y699	PHOSPHORYLATION	448198	TAKAADGyVKPQIKQ		activity, induced	transcription, altered; cell growth, altered			5415; 5410121	30	22	2207	tetracycline inducible truncated (lacking Y699) mutant	
CNR1	GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR	P47746	12801	Cnr1		mouse	T466	PHOSPHORYLATION	22342306	KVTMSVStDTSAEAL		receptor desensitization, induced				21686207	1	0	1		
RGS2	GTPase activating protein, misc.	P41220	5997	RGS2	1q31	human	S46	PHOSPHORYLATION	10772900	KDWKTRLsYFLQNSS		activity, induced; intracellular localization				10296909	1	0	0	RGS2 phosphorylation increases G-alpha GTPase activity, and association with membrane fraction.  	
PKCE	EC 2.7.11.13; KINASE; Kinase, protein; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor)	P09216	29340	Prkce		rat	S729	PHOSPHORYLATION	448789	QEEFKGFsYFGEDLM	Pkinase_C	intracellular localization; enzymatic activity, induced				5783	15	9	5		
GluR1	Channel, calcium; Channel, ligand-gated; Membrane protein, integral; Membrane protein, multi-pass	P42261	2890	GRIA1	5q31.1	human	S836	PHOSPHORYLATION	467226	CYKSRSEsKRMKGFC		molecular association, regulation; intracellular localization		EPB41L1(INDUCES)		9158103	7	0	0	enhances receptor insertion into plasma membrane	
HTRA2	EC 3.4.21.108; Membrane protein, integral; Mitochondrial; Protease	O43464	27429	HTRA2	2p12	human	S142	PHOSPHORYLATION	487466	VPSPPPAsPRSQYNF		enzymatic activity, induced				12285	3	0	1		
CK2A1	EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor)	P68400	1457	CSNK2A1	20p13	human	S362	PHOSPHORYLATION	449986	ISSVPTPsPLGPLAG		enzymatic activity, induced				14511600	2	1	0		
HMGA1	DNA binding protein	Q8K585	117062	Hmga1		rat	T53	PHOSPHORYLATION	451515	KEPSEVPtPKRPRGR		molecular association, regulation			DNA(DISRUPTS)	8553	5	23	24		
SSB	Transcription initiation complex	P32067	20823	Ssb		mouse	S199	PHOSPHORYLATION	2862901	KNEERKQsKVEAKLK		molecular association, regulation			RNA(INDUCES)	2865432	1	0	0		
REM1	G protein; G protein, monomeric, RGK	O35929	19700	Rem1		mouse	S262	PHOSPHORYLATION	1211201	PSPRRRAsLGQRARR		intracellular localization				1172800	1	0	0		
STMN1	Cytoskeletal protein	P16949	3925	STMN1	1p36.11	human	S25	PHOSPHORYLATION	448555	QAFELILsPRSKESV	Stathmin	molecular association, regulation; activity, inhibited; phosphorylation	cell cycle regulation; cytoskeletal reorganization	TUBA1A(DISRUPTS); TUBB(DISRUPTS)		7802; 8835; 2798	34	65	82		
GRASP55	Motility/polarity/chemotaxis; Vesicle protein	Q9R064	113961	Gorasp2		rat	T225	PHOSPHORYLATION	470123	QMTGTPItPLKDGFT		molecular association, regulation	cell cycle regulation; cytoskeletal reorganization	GRASP55(DISRUPTS)		2725506; 12576800	4	12	6	inhibits Golgi stack formation in interphase cells and enhances Golgi fragmentation in mitotic cells	
GANP	Acetyltransferase; Karyopherin	Q9WUU9	54387	Mcm3ap		mouse	S502	PHOSPHORYLATION	448619	FWHKKKIsPSKKLFP		enzymatic activity, induced				1770	1	2	0	Phosphorylation of this site appears to correlate with higher DNA-primase activity 	
FMR1	Translation	Q06787	2332	FMR1	Xq27.3	human	S511	PHOSPHORYLATION	14323700	SDHRDELsDWSLAPT	FXR1P_C	intracellular localization				14058617	1	0	0		
CD19	Cell surface; Membrane protein, integral	P25918	12478	Cd19		mouse	Y493	PHOSPHORYLATION	447638	SSLGSQSyEDMRGIL		activity, induced; molecular association, regulation	cell differentiation, altered	PIK3R1(INDUCES)		5862; 12482418	5	3	15	regulate Akt activation and B-cell differentiation through binding to PI3KR1	
rhodopsin	GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR	P02699	509933	RHO		cow	T340	PHOSPHORYLATION	448681	ASTTVSKtETSQVAP		molecular association, regulation; protein conformation		SAG(INDUCES)		3621	1	1	0	Computational and in vitro data. S343 may be a weaker interaction.	
POLL	DNA repair; EC 2.7.7.7; EC 4.2.99.-; Lyase; Transferase	Q9UGP5	27343	POLL	10q23	human	T553	PHOSPHORYLATION	5312301	GPGRVLPtPTEKDVF		protein stabilization; ubiquitination				5007902	1	0	0	prevents POLL ubiquitination	
dCK	EC 2.7.1.74; Kinase, other; Nucleotide Metabolism - purine; Nucleotide Metabolism - pyrimidine	P27707	1633	DCK	4q13.3-q21.1	human	S11	PHOSPHORYLATION	460585	PPKRSCPsFSASSEG		phosphorylation				14851000	4	15	5	regulates phosphorylation of S74	
CTNND1	Actin binding protein; Adaptor/scaffold; Cell adhesion; G protein regulator, misc.; Motility/polarity/chemotaxis	P30999	12388	Ctnnd1		mouse	Y217	PHOSPHORYLATION	449647	PDGYGRHyEDGYPGG		molecular association, regulation		RhoA(INDUCES); CDH1(INDUCES)		9157	1	11	76		
ANPA	EC 4.6.1.2; Guanylyl cyclase; KINASE; Kinase, protein; Lyase; Membrane protein, integral; Nucleotide Metabolism - purine; Protein kinase, RGC; Protein kinase, dual-specificity; Receptor, misc.	P18910	24603	Npr1		rat	S515	PHOSPHORYLATION	14364503	WEDLQPSsLERHLRS		receptor desensitization, altered; enzymatic activity, inhibited; protein conformation				17482904; 14058621	1	2	0		
PICK1	Adaptor/scaffold; Cell development/differentiation; Ligand, receptor tyrosine kinase	Q9EP80	84591	Pick1		rat	T82	PHOSPHORYLATION	14146800	GRSIKGKtKVEVAKM	PDZ	molecular association, regulation		GluR2(DISRUPTS)		14081220	1	0	0	disrupts GluR2 clustering	
ARAP3	GTPase activating protein, ARF; GTPase activating protein, Rac/Rho; Motility/polarity/chemotaxis	Q8R5G7	106952	Arap3		mouse	Y1404	PHOSPHORYLATION	454958	PVYEEPVyEEVGAFP			cell motility, altered; cytoskeletal reorganization			4350	3	1	3		
DGKA	EC 2.7.1.107; Kinase, lipid; Lipid Metabolism - glycerolipid; Lipid Metabolism - glycerophospholipid; Motility/polarity/chemotaxis	P23743	1606	DGKA	12q13.3	human	Y335	PHOSPHORYLATION	486452	ILPPSSIyPSVLASG		intracellular localization; enzymatic activity, induced	cell motility, altered			5563; 12178; 2807207	4	0	0	attenuates ERK phosphorylation; enzymatic activation - in vitro	
VHL	Tumor suppressor; UBIQUITIN LIGASE; Ubiquitin ligase	P40337	7428	VHL	3p25.3	human	S33	PHOSPHORYLATION	15573201	EEDGGEEsGAEESGP		protein degradation	transcription, altered			15331032	1	0	0	regulates p53 activity and degradation of HIF1A	
PPP1R3C	Motility/polarity/chemotaxis; Protein phosphatase, regulatory subunit	Q9UQK1	5507	PPP1R3C	10q23-q24	human	S33	PHOSPHORYLATION	6423500	MRLCLAHsPPVKSFL		protein degradation; ubiquitination; enzymatic activity, inhibited				6331320	1	2	0		
PAK1	EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, STE; Protein kinase, Ser/Thr (non-receptor)	P35465	29431	Pak1		rat	T84	PHOSPHORYLATION	450680	LPSDFEHtIHVGFDA	PBD	enzymatic activity, inhibited				3065	1	0	0	prevents activation by Cdc42	
p21Cip1	Cell cycle regulation; Inhibitor protein	P38936	1026	CDKN1A	6p21.2	human	K75	UBIQUITINATION	9897000	VRGLGLPkLYLPTGP		protein degradation; ubiquitination				5669	2	3	4	UV-induced 	
vimentin	Cytoskeletal protein; Motility/polarity/chemotaxis	P08670	7431	VIM	10p13	human	S8	PHOSPHORYLATION	471087	MSTRSVSsSSYRRMF	Filament_head		cell motility, altered			7549203	2	1	1		
EGR1	C2H2-type zinc finger protein; DNA binding protein; Transcription factor	P18146	1958	EGR1	5q31.1	human	S301	PHOSPHORYLATION	11423702	AFATQSGsQDLKALN			transcription, altered		DNA(DISRUPTS)	10274604	1	0	0		
UNC5C	Membrane protein, integral; Receptor, misc.	O08747	22253	Unc5c		mouse	Y568	PHOSPHORYLATION	12563302	QGRVYEMyVTVHRKE	ZU5	molecular association, regulation		PLCG1(INDUCES); SHP-2(INDUCES)		12482246	1	1	0	SHP-2 and UNC5C bind in vitro and in vivo 	
Btk	EC 2.7.10.2; KINASE; Kinase, protein; Protein kinase, TK; Protein kinase, tyrosine (non-receptor)	P35991	12229	Btk		mouse	Y223	PHOSPHORYLATION	447485	LKKVVALyDYMPMNA	SH3_1	molecular association, regulation; enzymatic activity, induced	cell growth, altered	GTF2I(INDUCES)		476; 475	15	7	252	PI 3-kinase is required for BTK activation and transformation. 	
PDE4D iso2	EC 3.1.4.17; Nucleotide Metabolism - purine; Phosphodiesterase	Q08499-2	5144	PDE4D	5q12	human	S578	PHOSPHORYLATION	451090	YQSTIPQsPSPAPDD		enzymatic activity, inhibited				9132; 8256; 3199	4	2	0	regulates levels of intracellular cAMP	
FCP1	EC 3.1.3.16; Motility/polarity/chemotaxis; PHOSPHATASE; Protein phosphatase, Ser/Thr (non-receptor); Transcription initiation complex	Q9Y5B0	9150	CTDP1	18q23	human	T584	PHOSPHORYLATION	455468	EEEEEEDtDEDDHLI		molecular association, regulation	transcription, altered	GTF2F1(INDUCES)		6829233; 5226	2	0	0		
eIF6	Translation; Translation initiation	P56537	3692	EIF6	20q12	human	S175	PHOSPHORYLATION	17535703	EDQDELSsLLQVPLV	eIF-6	intracellular localization				17431524	1	0	0	required for the nuclear export of eIF6	
CTNND1 iso3	Actin binding protein; Adaptor/scaffold; Cell adhesion; G protein regulator, misc.; Motility/polarity/chemotaxis	P30999-3	12388	Ctnnd1		mouse	Y257	PHOSPHORYLATION	450397	APSRQDVyGPQPQVR			cell cycle regulation; cell motility, altered			2790302	2	18	713		
XRCC4	DNA repair	Q13426	7518	XRCC4	5q14.2	human	T233	PHOSPHORYLATION	2286405	DPVYDEStDEESENQ	XRCC4; DUF3629	molecular association, regulation		APLF(INDUCES); Pnk1(INDUCES)		2195719; 15562523	2	3	0		
Myb	DNA binding protein; Transcription factor	P10242	4602	MYB	6q22-q23	human	S11	PHOSPHORYLATION	448186	RPRHSIYsSDEDDED		molecular association, regulation	transcription, altered		DNA(DISRUPTS)	2173	5	1	1		
DRD2	GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR	P14416	1813	DRD2	11q23	human	S354	PHOSPHORYLATION	467255	PNGKTRTsLKTMSRR	7tm_1	molecular association, regulation; intracellular localization; activity, inhibited		FLNA(DISRUPTS)		8204	1	0	0	inhibits D2 receptor clustering on the cell surface	
MARCKS	Actin binding protein; Motility/polarity/chemotaxis	P16527	396473	MARCKS		chicken	S26	PHOSPHORYLATION	455959	PGEAVAAsPSKANGQ	MARCKS	molecular association, regulation		ACTA1(INDUCES)		7549209	6	25	8		
Rb-like 2	Transcription, coactivator/corepressor	Q08999	5934	RBL2	16q12.2	human	S672	PHOSPHORYLATION	448254	TLYDRYSsPPASTTR		protein degradation; molecular association, regulation	cell cycle regulation	SKP2(INDUCES); E2F4(DISRUPTS)		8696; 1200; 5981	4	4	7		
STXBP1	Vesicle protein	P61765	25558	Stxbp1		rat	S306	PHOSPHORYLATION	448743	VSQEVTRsLKDFSSS	Sec1; YlbD_coat		exocytosis, altered			9181	3	0	0	regulates protein secretion by increasing vesicle pools replenishment after stimulation	
SLK	EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, STE; Protein kinase, Ser/Thr (non-receptor)	Q9H2G2	9748	SLK	10q24.33	human	S347	PHOSPHORYLATION	466943	SSDLSIAsSEEDKLS		enzymatic activity, inhibited				8131	1	17	2	site is critical for v-src dependent modulation of SLK kinase activity	
CIITA	DNA binding protein; Transcription, coactivator/corepressor	P33076	4261	CIITA	16p13	human	S293	PHOSPHORYLATION	2902203	STSPFAPsATDLPSM		intracellular localization	transcription, altered			8373	1	0	0		
CDCA7		Q9BWT1	83879	CDCA7	2q31	human	T163	PHOSPHORYLATION	4774845	SRRPRRRtFPGVASR		molecular association, regulation; intracellular localization		14-3-3 beta(INDUCES); Myc(DISRUPTS)		27257044	1	3	6	 14-3-3 competes with MYC for binding to CDCA7 ; localization to cytoplasm after binding of 14-3-3	
G6b	Immunoglobulin superfamily; Membrane protein, integral; Receptor, misc.	O95866	80739	G6B	6p21.33	human	S226	PHOSPHORYLATION	1983255	LSRPRRLsTADPADA		molecular association, regulation		SH2D1B(NOT_REPORTED); Arg(NOT_REPORTED)		27932900	0	2	0		
TRPM4	Membrane protein, integral; Membrane protein, multi-pass	Q8TD43	54795	TRPM4	19q13.33	human	S1152	PHOSPHORYLATION	12559512	SERLKRTsQKVDLAL		activity, induced				12482290	1	0	0		
SEPT5	Cell cycle regulation; Cytoskeletal protein; Hydrolase; Vesicle protein	Q9JJM9	116728	Sept5		rat	S161	PHOSPHORYLATION	2753800	HCCLYFIsPFGHGLR	Septin	molecular association, regulation	exocytosis, altered	STX1A(DISRUPTS)		2704315	1	0	0		
COL17A1	Extracellular matrix; Membrane protein, integral; Motility/polarity/chemotaxis	Q9UMD9	1308	COL17A1	10q24.3	human	S544	PHOSPHORYLATION	484007	KIGLHSDsQEELWMF			cell adhesion, altered			11957	1	0	0	regulates COL17A1 shedding of ectodomain	
CCR7	GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Motility/polarity/chemotaxis; Receptor, GPCR	P32248	1236	CCR7	17q12-q21.2	human	S377	PHOSPHORYLATION	455292	AETTTTFsP______		phosphorylation				4472	1	0	0	ERK1/2 phosphorylation	
neurogenin 1	Cell development/differentiation; DNA binding protein; Transcription factor	P70595	29410	Neurog1		rat	S208	PHOSPHORYLATION	7590802	SPLSDPSsPSASEDF			transcription, induced; cell growth, altered			7543502	1	0	0		
GRK2	EC 2.7.11.15; KINASE; Kinase, protein; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor)	P25098	156	ADRBK1	11q13.1	human	Y86	PHOSPHORYLATION	447727	ARPLVEFyEEIKKYE	RGS	protein degradation; molecular association, regulation		G-alpha(q)(INDUCES)		8002; 8017	5	0	0		
p27Kip1	Cell cycle regulation; Inhibitor protein; Protein kinase, regulatory subunit	P46527	1027	CDKN1B	12p13.1-p12	human	Y88	PHOSPHORYLATION	456818	KGSLPEFyYRPPRPP		protein degradation; molecular association, regulation; intracellular localization; activity, inhibited	cell cycle regulation	CDK2(INDUCES); CDK2(DISRUPTS); CDK4(INDUCES)		3394302; 6859; 20834140; 9306	9	0	0	When phosphorylated at Y88 or Y89, p27 able to bind but was unable to inhibit cdk4 in vitro and in vivo.	
USF1	DNA binding protein; Transcription factor	P22415	7391	USF1	1q22-q23	human	T153	PHOSPHORYLATION	463815	EALLGQAtPPGTGQF		acetylation	transcription, induced; transcription, inhibited			7543524; 7861; 7886	4	0	0	stimulates acetylation of K199	
APOBEC3G	EC 3.5.4.-; Hydrolase; RNA binding protein; RNA processing	Q9HC16	60489	APOBEC3G	22q13.1-q13.2	human	T218	PHOSPHORYLATION	21656100	WVRGRHEtYLCYEVE	APOBEC_N	enzymatic activity, inhibited				21655809	1	0	0		
GLP1R	GPCR, family 2; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR	P32301	25051	Glp1r		rat	S452	PHOSPHORYLATION	451370	SGATVGSsVYAATCQ		receptor desensitization, altered				3574	1	0	0		
XBP1	DNA binding protein; Transcription factor	O35426	22433	Xbp1		mouse	S61	PHOSPHORYLATION	21688102	RQRLTHLsPEEKALR	CASP_C; Macoilin; GAS; ATG16; HOOK; UPF0242; Herpes_BLRF2; DUF2205; bZIP_2	intracellular localization				21683734	2	2	0	important for nuclear translocation of XBP1- not in obese (ob/ob) mice	
PCAF	ACETYLTRANSFERASE; Acetyltransferase; EC 2.3.1.48; Nuclear receptor co-regulator	Q92831	8850	KAT2B	3p24	human	K442	ACETYLATION	458988	HVLEEAKkPRVMGDI		enzymatic activity, induced				7551	1	0	0	in vitro	
SYNJ1	Carbohydrate Metabolism - inositol phosphate; EC 3.1.3.36; Motility/polarity/chemotaxis; Phosphatase, lipid; Vesicle protein	Q62910	85238	Synj1		rat	S1160	PHOSPHORYLATION	450679	REMEAPKsPGTARKD		molecular association, regulation		endophilin 1(DISRUPTS)		3064	1	2	2		
AML2	DNA binding protein; Transcription factor	Q13761	864	RUNX3	1p36	human	S356	PHOSPHORYLATION	7705800	SSSGGDRsPTRMLAS	RunxI	protein degradation; ubiquitination	transcription, altered			7543538	1	0	0	degradation by cyclin D1	
PSEN1	Cell surface; EC 3.4.23.-; Membrane protein, integral; Membrane protein, multi-pass; Mitochondrial; Protease	P49768	5663	PSEN1	14q24.3	human	S319	PHOSPHORYLATION	3397301	NSKYNAEsTERESQD	Presenilin	protein stabilization; enzymatic activity, induced				3301200	1	0	0		
MKK6 iso2	EC 2.7.12.2; KINASE; Kinase, protein; Protein kinase, STE; Protein kinase, dual-specificity	P52564-2	5608	MAP2K6	17q24.3	human	S151	PHOSPHORYLATION	448194	ISGYLVDsVAKTIDA	Pkinase	enzymatic activity, induced				716	11	9	46		
p53	Activator protein; DNA binding protein; Motility/polarity/chemotaxis; Nuclear receptor co-regulator; Transcription factor; Tumor suppressor	P04637	7157	TP53	17p13.1	human	S106	PHOSPHORYLATION	27300200	SQKTYQGsYGFRLGF	DEC-1_N; P53	protein stabilization		MDM2(DISRUPTS)		27282600	1	1	0		
TSC2	Cell cycle regulation; GTPase activating protein, misc.; Nuclear receptor co-regulator; Tumor suppressor	P49815	7249	TSC2	16p13.3	human	S981	PHOSPHORYLATION	454014	AFRCRSIsVSEHVVR		molecular association, regulation; intracellular localization		14-3-3 zeta(INDUCES); 14-3-3 epsilon(INDUCES)		7859	3	11	13		
EpoR	EC 2.7.10.2; Membrane protein, integral; Receptor, cytokine	P19235	2057	EPOR	19p13.3-p13.2	human	Y489	PHOSPHORYLATION	457448	DGPYSNPyENSLIPA			apoptosis, inhibited			8833	3	0	0		
PKCD	EC 2.7.10.2; EC 2.7.11.13; KINASE; Kinase, protein; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor)	Q05655	5580	PRKCD	3p21.31	human	T141	PHOSPHORYLATION	1028305	EDEAKFPtMNRRGAI	DUF4206	enzymatic activity, induced				7549218	1	4	1		
TrkA	EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Protein kinase, TK; Protein kinase, tyrosine (receptor)	P04629	4914	NTRK1	1q21-q22	human	Y791	PHOSPHORYLATION	447765	LAQAPPVyLDVLG__		molecular association, regulation; enzymatic activity, induced	apoptosis, induced; cell growth, altered	PLCG1(INDUCES)		5955614; 1306; 799	7	0	3		
LLGL1	Cell adhesion; Cytoskeletal protein; Motility/polarity/chemotaxis	NP_032528	16897	Llgl1		mouse	S650	PHOSPHORYLATION	449914	LAMEGPLsRVKSLKK		intracellular localization				2469	1	0	0		
E2A iso2	DNA binding protein; Transcription factor	P15923-2	6929	TCF3	19p13.3	human	S359	PHOSPHORYLATION	465682	SPSTPVGsPQGLAGT		molecular association, regulation	transcription, induced	NEUROD1(INDUCES)		8116	2	4	25		
doublecortin iso2	Cytoskeletal protein; Motility/polarity/chemotaxis	O43602-2	1641	DCX	Xq22.3-q23	human	T321	PHOSPHORYLATION	451361	TSSSQLStPKSKQSP		intracellular localization	cell motility, altered; cytoskeletal reorganization			8909	2	0	2	affects doublecortin localization to growth cones, neurite outgrowth, and neuronal motility	
PXN iso2	Adaptor/scaffold; Cell adhesion; Cytoskeletal protein; Motility/polarity/chemotaxis	P49023-2	5829	PXN	12q24.31	human	S178	PHOSPHORYLATION	448603	PPLPGALsPLYGVPE	Paxillin	protein stabilization; intracellular localization	cytoskeletal reorganization; cell adhesion, altered			7119501	7	0	0	in response to E4orf4;  Phosphorylated S178 recruits, retains, and stabilizes paxillin to focal adhesions.	
p53	Activator protein; DNA binding protein; Motility/polarity/chemotaxis; Nuclear receptor co-regulator; Transcription factor; Tumor suppressor	P04637	7157	TP53	17p13.1	human	S33	PHOSPHORYLATION	447531	LPENNVLsPLPSQAM		activity, induced; molecular association, regulation; phosphorylation	apoptosis, induced; transcription, altered; cell growth, altered	CBP(INDUCES); Pin1(INDUCES)		6045; 6046; 5010605; 3394303; 5004513; 7423; 18378508; 6432	30	3	0		
AT1	GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR	P30556	185	AGTR1	3q24	human	S338	PHOSPHORYLATION	452092	STKMSTLsYRPSDNV		activity, induced; molecular association, regulation; intracellular localization; receptor internalization, altered		ARRB1(INDUCES); ARRB2(INDUCES)		8345; 8199	4	0	0		
ADRB2	GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR	P07550	154	ADRB2	5q31-q32	human	S364	PHOSPHORYLATION	458915	NGNTGEQsGYHVEQE		molecular association, regulation; receptor desensitization, altered; receptor internalization, altered		ARRB2(INDUCES)		8115; 5354441; 7454	4	0	0	PD-N mutant (residues 355-364) failed to recruit ARRB2 to the plasma membrane 	
CTNNB1	Actin binding protein; Cell adhesion; Motility/polarity/chemotaxis; Nuclear receptor co-regulator; Transcription factor	P35222	1499	CTNNB1	3p21	human	T393	PHOSPHORYLATION	449562	RNLSDAAtKQEGMEG		activity, induced; molecular association, regulation; protein stabilization; phosphorylation	transcription, induced; transcription, altered	axin 1(DISRUPTS)		9385200; 2233	2	0	0		
NFAT4	DNA binding protein; Transcription factor	Q12968	4775	NFATC3	16q22.2	human	S163	PHOSPHORYLATION	448857	SYRESSLsPSPASSI		intracellular localization	transcription, inhibited			2029	1	2	0		
RARG iso2	DNA binding protein; Nuclear receptor	P18911-2	19411	Rarg		mouse	S68	PHOSPHORYLATION	455544	EMVPSSPsPPPPPRV		activity, induced; protein degradation	transcription, altered			5430	2	0	0		
SHARP	Nuclear receptor co-regulator; Spliceosome; Transcription factor	Q96T58	23013	SPEN	1p36	human	T3568	PHOSPHORYLATION	455622	EGVARRMtVETDYCL	SPOC		transcription, altered			5508	1	0	0		
LAT	Adaptor/scaffold; Membrane protein, integral	O43561	27040	LAT	16p11.2	human	Y161	PHOSPHORYLATION	447760	DDYHNPGyLVVLPDS		molecular association, regulation		PLCG1(INDUCES)		8611	13	0	1		
SRC-3	ACETYLTRANSFERASE; Acetyltransferase; EC 2.3.1.48; Motility/polarity/chemotaxis; Nuclear receptor co-regulator; Transcription, coactivator/corepressor	Q9Y6Q9	8202	NCOA3	20q12	human	S543	PHOSPHORYLATION	454108	SLLSTLSsPGPKLDN		molecular association, regulation		ER-alpha(DISRUPTS)		4214	5	0	0	Mutations to alanine inhibited protein-protein interactions. 	
PLD2	EC 3.1.4.4; Lipid Metabolism - ether lipid; Lipid Metabolism - glycerophospholipid; Motility/polarity/chemotaxis; Phospholipase	O14939	5338	PLD2	17p13.1	human	T252	PHOSPHORYLATION	456498	LLYMCLEtGAISFVQ	PH	enzymatic activity, induced				6687	1	1	0		
PAK1	EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, STE; Protein kinase, Ser/Thr (non-receptor)	P35465	29431	Pak1		rat	S149	PHOSPHORYLATION	448171	YMSFTDKsAEDYNSS		enzymatic activity, induced				738	1	1	24		
CASKIN1	Adaptor/scaffold	Q8VHK2	140722	Caskin1		rat	Y296	PHOSPHORYLATION	472784	TKDYCNNyDLTSLNV	SH3_2	protein conformation				27257053	1	2	28	Phosphorylation leads to structural changes in the SH3 domain. 	
DIXDC1	Cell adhesion; Cell development/differentiation	Q80Y83	330938	Dixdc1		mouse	S250	PHOSPHORYLATION	15714601	CSSLTSPsPIHSAKS		molecular association, regulation	cell motility, altered; cytoskeletal reorganization	NDEL1(INDUCES)		15675506	1	2	0	DIXDC1/NDEL1/DISC1 complex	
Lck	EC 2.7.10.2; KINASE; Kinase, protein; Protein kinase, TK; Protein kinase, tyrosine (non-receptor)	P06240	16818	Lck		mouse	S59	PHOSPHORYLATION	447820	EGSLPPAsPLQDNLV		enzymatic activity, inhibited				1147	7	1	5		
SgK307	Cancer Testis Antigen (CTA); KINASE; Kinase, protein; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor)	Q8IWB6	56155	TEX14	17q22	human	T727	PHOSPHORYLATION	25158903	SNLNNMStTEEYLIS		molecular association, regulation; intracellular localization		PLK1(INDUCES)		25082834	1	0	0		
STMN1	Cytoskeletal protein	P16949	3925	STMN1	1p36.11	human	S38	PHOSPHORYLATION	448556	SVPEFPLsPPKKKDL	Stathmin; CDC37_N	protein degradation; molecular association, regulation; activity, inhibited; phosphorylation	cell cycle regulation; cytoskeletal reorganization	TUBA1A(DISRUPTS); TUBB(DISRUPTS)		6702322; 7802; 7910523; 8835; 2798	34	62	150		
CTLA-4	Immunoglobulin superfamily; Membrane protein, integral	P16410	1493	CTLA4	2q33	human	Y218	PHOSPHORYLATION	450898	CEKQFQPyFIPIN__		molecular association, regulation; intracellular localization		SHP-1(INDUCES)		5955629; 8405	3	0	0		
PACT	Activator protein; RNA binding protein; RNA processing	O75569	8575	PRKRA	2q31.2	human	S246	PHOSPHORYLATION	470037	TDYIQLLsEIAKEQG	dsrm		apoptosis, altered			8920	3	0	1	activates PKR	
ASK1	EC 2.7.11.25; KINASE; Kinase, protein; Protein kinase, STE; Protein kinase, Ser/Thr (non-receptor)	Q99683	4217	MAP3K5	6q22.33	human	S1033	PHOSPHORYLATION	451423	EDHSAPPsPEEKDSG		enzymatic activity, inhibited	apoptosis, altered			3625	1	16	0		
CSF2RB	Membrane protein, integral; Receptor, cytokine	P32927	1439	CSF2RB	22q13.1	human	Y593	PHOSPHORYLATION	450103	SFDFNGPyLGPPHSR		activity, induced; molecular association, regulation; receptor internalization, altered; phosphorylation	apoptosis, altered; cell motility, altered; transcription, altered; cell growth, altered	Shc1(INDUCES); Fos(NOT_REPORTED); SHP-2(INDUCES); Grb2(INDUCES)		3604; 2722; 8533; 3210; 2707; 3318; 12072; 3329; 8395	12	0	0		
GSK3B	EC 2.7.11.1; EC 2.7.11.26; KINASE; Kinase, protein; Protein kinase, CMGC; Protein kinase, Ser/Thr (non-receptor)	Q9WV60	56637	Gsk3b		mouse	S9	PHOSPHORYLATION	449111	SGRPRTTsFAESCKP		intracellular localization; enzymatic activity, inhibited; phosphorylation	cytoskeletal reorganization; cell growth, altered			6798; 5300; 13270512; 15278809; 687; 5901; 2668504; 6103; 6842224; 4904523	345	20	210	Phosphorylation induces cardiac hypertrophy in reponse to pressure.; Moderate reduction of GSK-3 activity induced axon branching  	
MLL	Cell cycle regulation; EC 2.1.1.43; METHYLTRANSFERASE; Methyltransferase; Methyltransferase, protein lysine; Transcription factor	Q03164	4297	MLL	11q23	human	S516	PHOSPHORYLATION	4709074	VHPPLPIsQSPENES		protein stabilization; molecular association, regulation; intracellular localization	cell cycle regulation	SKP2(DISRUPTS)		15562525	1	2	0	accumulates on chromatin	
TAUT	Membrane protein, integral; Membrane protein, multi-pass; Transporter	Q00589	404000	SLC6A6		dog	S322	PHOSPHORYLATION	450688	YNKYKYNsYRDCMLL	SNF	activity, inhibited				3132	1	0	0	Taurine transport mediated by the S322A mutant was increased 3-fold as compared with the wild-type molecule 	
IP3R1	Channel, calcium; Channel, ligand-gated; Membrane protein, integral; Membrane protein, multi-pass; Receptor, misc.	P29994	25262	Itpr1		rat	T945	PHOSPHORYLATION	3635217	GGGFLPMtPMAAAPE		molecular association, regulation				26341715	1	1	9	T945 phosphorylation reduces IP3 binding affiinity and Ca2+ release is reduced.	
N-CoR1	Nuclear receptor co-regulator; Transcription, coactivator/corepressor	Q60974	20185	Ncor1		mouse	S2348	PHOSPHORYLATION	2888301	NKSNSRKsKSPIPGQ		molecular association, regulation		14-3-3 beta(INDUCES)		2858606	1	2	1		
HCN2	Channel, cation; Membrane protein, integral; Membrane protein, multi-pass	O88703	15166	Hcn2		mouse	S641	PHOSPHORYLATION	18454000	DRIGKKNsILLHKVQ		activity, inhibited				18410841	1	1	0		
Tyk2	EC 2.7.10.2; KINASE; Kinase, protein; Protein kinase, TK; Protein kinase, tyrosine (non-receptor)	P29597	7297	TYK2	19p13.2	human	Y1055	PHOSPHORYLATION	447503	VPEGHEYyRVREDGD	Pkinase_Tyr	enzymatic activity, induced				801	4	2	5		
NPM-ALK	Kinase, protein; Protein kinase, TK; Protein kinase, tyrosine (receptor)	AAA58698		NPM/ALK		human	Y342	PHOSPHORYLATION	27275106	RDIYRASyYRKGGCA	Pkinase_Tyr	enzymatic activity, induced				11387255	2	2	0		
JAK2	EC 2.7.10.2; KINASE; Kinase, protein; Protein kinase, TK; Protein kinase, tyrosine (non-receptor)	Q62120	16452	Jak2		mouse	Y613	PHOSPHORYLATION	1811800	HKHLVLNyGVCVCGE	Pkinase_Tyr	enzymatic activity, induced				1713155	1	0	0	Y613E mutant shows constitutive activation of Jak2, which depends on the presence of EpoR 	
MOR-1	GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR	P33535	25601	Oprm1		rat	S261	PHOSPHORYLATION	447781	LMILRLKsVRMLSGS	7tm_1	receptor desensitization, altered		MOR-1(NOT_REPORTED)		2603	2	0	1		
ADRB2	GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR	P07550	154	ADRB2	5q31-q32	human	T68	PHOSPHORYLATION	4047201	FERLQTVtNYFITSL	7tm_1	activity, induced				970035	1	0	0	G-protein activation	
MST1	Autophagy; EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, STE; Protein kinase, Ser/Thr (non-receptor)	Q13043	6789	STK4	20q11.2-q13.2	human	T387	PHOSPHORYLATION	450050	TMKRRDEtMQPAKPS		enzymatic activity, induced	apoptosis, altered			14821617	3	1	7		
LAT	Adaptor/scaffold; Membrane protein, integral	O54957	16797	Lat		mouse	Y175	PHOSPHORYLATION	448004	SVESCEDyVNVPESE		intracellular localization; phosphorylation	cell adhesion, altered	Fyn(INDUCES)		4228; 970001	13	0	17	Localization of recruited  PLCG2 to the membrane/cytoskeleton;  Fyn may be involved in LAT phosphorylation.; regulates exocytosis and cytokine secretion	
MCL1	Apoptosis; Channel, misc.; Inhibitor protein; Membrane protein, integral; Mitochondrial	Q07820	4170	MCL1	1q21	human	S121	PHOSPHORYLATION	1172400	PAADAIMsPEEELDG			apoptosis, induced			8630	4	1	0		
SOX9	DNA binding protein; Transcription factor	Q04887	20682	Sox9		mouse	S64	PHOSPHORYLATION	451039	EPDLKKEsEEDKFPV	Sox_N	activity, induced	transcription, altered			9201006	5	0	0	promotes expression of osteochondrogenic markers 	
GIT1	GTPase activating protein, ARF; Motility/polarity/chemotaxis	Q9Y2X7	28964	GIT1	17p11.2	human	S700	PHOSPHORYLATION	465672	PALEPVRsSLRLLNA	GIT1_C	molecular association, regulation	cytoskeletal reorganization	PXN iso2(INDUCES)		8090	1	1	0		
claudin 16	Cell adhesion; Membrane protein, integral; Membrane protein, multi-pass	Q91Y55	155268	Cldn16		rat	T233	PHOSPHORYLATION	11555106	AKMYAVDtRV_____		intracellular localization				11424228	1	0	0		
PSD-93	Adaptor/scaffold	Q91XM9	23859	Dlg2		mouse	Y348	PHOSPHORYLATION	450885	TRPPEPVySTVNKLC		molecular association, regulation		CSK(INDUCES)		3044	1	1	147		
Syk	EC 2.7.10.2; KINASE; Kinase, protein; Protein kinase, TK; Protein kinase, tyrosine (non-receptor)	P48025	20963	Syk		mouse	Y342	PHOSPHORYLATION	447659	LPMDTEVyESPYADP		molecular association, regulation; phosphorylation; enzymatic activity, induced	endocytosis, altered; cell motility, altered; cell adhesion, altered; signaling pathway regulation	Fgr(INDUCES)		7991125; 1973; 4300; 4357	9	7	114		
STAT1	DNA binding protein; Transcription factor	P42225	20846	Stat1		mouse	Y701	PHOSPHORYLATION	447754	DDPKRTGyIKTELIS		molecular association, regulation; intracellular localization; phosphorylation	transcription, induced; cell growth, altered		DNA(INDUCES)	6271032; 2207; 1281; 2745108; 2670112; 4282204	124	4	61		
HES1	Cell development/differentiation; Motility/polarity/chemotaxis; Transcription factor	Q14469	3280	HES1	3q28-q29	human	S38	PHOSPHORYLATION	3882731	ASEHRKSsKPIMEKR	HLH	molecular association, regulation	cytoskeletal reorganization; transcription, altered		DNA(DISRUPTS)	10274610	1	0	1	in vivo neurite outgrowth	
p73	DNA binding protein; Transcription factor	O15350	7161	TP73	1p36.3	human	T27	PHOSPHORYLATION	2063601	SSLEPDStYFDLPQS		molecular association, regulation; activity, inhibited	transcription, inhibited		DNA(DISRUPTS)	2831784	2	0	0		
p27Kip1	Cell cycle regulation; Inhibitor protein; Protein kinase, regulatory subunit	P46414	12576	Cdkn1b		mouse	S10	PHOSPHORYLATION	447874	NVRVSNGsPSLERMD		protein stabilization; intracellular localization	cell cycle regulation; cell growth, altered	CCNA1(DISRUPTS); CCNE1(DISRUPTS); CCND1(DISRUPTS)		3256112; 4688; 4567; 17613006; 19016932; 17827003	39	17	1	interaction is in vivo, not in vitro (due to localization); neurite outgrowth	
PIK4CB iso2	Carbohydrate Metabolism - inositol phosphate; EC 2.7.1.67; Kinase, lipid; Motility/polarity/chemotaxis	Q9UBF8-2	5298	PI4KB	1q21	human	T504	PHOSPHORYLATION	457624	EQLAHTPtAFKRDPE		intracellular localization				7836	1	1	0	T504-phosphorylated PIK4CB localizes in the nucleus 	
Fe65	Adaptor/scaffold; Apoptosis; Transcription regulation	Q9QXJ1	11785	Apbb1		mouse	Y547	PHOSPHORYLATION	451143	VQKFQVYyLGNVPVA	PID		transcription, induced			3335	2	1	0		
GFAP	Cytoskeletal protein	P14136	2670	GFAP	17q21	human	S13	PHOSPHORYLATION	449619	ITSAARRsYVSSGEM	Filament_head	molecular association, regulation; protein stabilization		Fascin(INDUCES)		2254; 6337829	10	4	0		
desmin	Cytoskeletal protein; Motility/polarity/chemotaxis	P17661	1674	DES	2q35	human	T76	PHOSPHORYLATION	449615	LRASRLGtTRTPSSY	Filament_head; IncA; DUF812		cytoskeletal reorganization			2253	1	0	0	Mutated desmin sites showed failure of desmin filaments to segregate into daughter cells. 	
PIGR	Immunoglobulin superfamily; Membrane protein, integral; Receptor, misc.	P01832	100328593	PIGR		rabbit	S682	PHOSPHORYLATION	451431	RRNVDRVsIGSYRTD		intracellular localization				3635	1	3	1	S682 phosphorylation is required for transcytosis of poly-Ig receptor in the absence digA. 	
PAG	Adaptor/scaffold; Membrane protein, integral	Q9JM80	64019	Pag1		rat	Y183	PHOSPHORYLATION	454746	NMVEDCLyETVKEIK			cell growth, altered			4338204	2	13	110		
TERT	DNA binding protein; EC 2.7.7.49; Transferase	O14746	7015	TERT	5p15.33	human	S824	PHOSPHORYLATION	11418801	AVRIRGKsYVQCQGI	RVT_1	enzymatic activity, induced				10274618	2	0	0		
SAV1	Adaptor/scaffold	Q9H4B6	60485	SAV1	14q13-q23	human	S27	PHOSPHORYLATION	7447103	KYVKKETsPLLRNLM	SynMuv_product	protein conformation	apoptosis, induced			21386602	1	3	0	 self-dimerization; increase in protein level	
CACNA1C	Channel, calcium; Membrane protein, integral; Membrane protein, multi-pass	P15381	100101555	CACB		rabbit	S1700	PHOSPHORYLATION	4714250	PEIRRAIsGDLTAEE		activity, induced				15785004	4	4	0	regulates basal activity of CACNA1C channels; required for stimulation of CACNA1C channels activity	
RAF1	EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, Ser/Thr (non-receptor); Protein kinase, TKL	P04049	5894	RAF1	3p25	human	T269	PHOSPHORYLATION	447747	NVHMVSTtLPVDSRM		enzymatic activity, induced				7991137; 2511; 1254	4	0	0		
LATS1	EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor)	O95835	9113	LATS1	6q25.1	human	T1079	PHOSPHORYLATION	457595	EHAFYEFtFRRFFDD	Pkinase_C	enzymatic activity, induced				7117	3	0	0		
PDGFRA	EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Protein kinase, TK; Protein kinase, tyrosine (receptor)	P16234	5156	PDGFRA	4q12	human	Y742	PHOSPHORYLATION	448657	KQADTTQyVPMLERK	Pkinase_Tyr	molecular association, regulation		PIK3R1(INDUCES)		4332	1	7	98		
IKKB	EC 2.7.11.10; KINASE; Kinase, protein; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor)	O88351	16150	Ikbkb		mouse	S679	PHOSPHORYLATION	5735027	SPDSMNVsRLSHPGQ		molecular association, regulation; phosphorylation		PPP2R3C(INDUCES)		17675011	1	1	1	interaction with PPP2R3C (aka G4-1) downregulates IKK-beta activity;  S181 phosphorylation increased in S679/682/689/692/697/701/705A mutant	
MYPT1	Motility/polarity/chemotaxis; Protein phosphatase, regulatory subunit	O14974	4659	PPP1R12A	12q15-q21	human	S910	PHOSPHORYLATION	1983104	SLLGRSGsYSYLEER			cell adhesion, altered			14148621	2	24	54		
TAO1	EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, STE; Protein kinase, Ser/Thr (non-receptor)	Q7L7X3	57551	TAOK1	17q11.2	human	S554	PHOSPHORYLATION	3627515	ELNSFLEsQKREYKL			cell cycle regulation			12287	1	0	1		
PDK1	EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor)	O55173	81745	Pdpk1		rat	S244	PHOSPHORYLATION	447693	SKQARANsFVGTAQY	Pkinase; YukC	enzymatic activity, induced				6553	43	48	211		
P70S6KB	EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor); Translation	Q9Z1M4	58988	Rps6kb2		mouse	S410	PHOSPHORYLATION	455989	SFQPKLRsPRRLNSS		phosphorylation				1172822	2	0	3		
InsR	EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Protein kinase, TK; Protein kinase, tyrosine (receptor)	P06213	3643	INSR	19p13.3-p13.2	human	Y1189	PHOSPHORYLATION	447681	RDIYETDyYRKGGKG	Pkinase_Tyr	molecular association, regulation; receptor internalization, altered; enzymatic activity, induced	transcription, altered	IRS2(INDUCES); APS(INDUCES); PTP1B(INDUCES)		4642412; 2852622; 9082; 8575; 3694; 2178; 8589	35	25	697	prolactin transcription	
PPP1R3A	Membrane protein, integral; Protein phosphatase, regulatory subunit	NP_001102692	500036	Ppp1r3a		rat	S67	PHOSPHORYLATION	449321	TSASRRVsFADSLGF		activity, inhibited				8753	5	2	0	inhibits glycogen synthase activity	
RPS3	Apoptosis; Ribosomal protein; Translation	P23396	6188	RPS3	11q13.3-q13.5	human	S209	PHOSPHORYLATION	9765788	KPLPDHVsIVEPKDE		intracellular localization				18668231	1	4	0		
PDE3B	EC 3.1.4.17; Membrane protein, integral; Membrane protein, multi-pass; Nucleotide Metabolism - purine; Phosphodiesterase	Q63085	29516	Pde3b		rat	S279	PHOSPHORYLATION	447699	VIRPRRRsSCVSLGE		molecular association, regulation		14-3-3 beta(INDUCES)		2418	2	4	69		
FOXM1	DNA binding protein; Transcription factor	Q08050	2305	FOXM1	12p13	human	T627	PHOSPHORYLATION	3194576	TPESWRLtPPAKVGG		protein stabilization	transcription, induced			22495316	1	2	5		
CTLA-4	Immunoglobulin superfamily; Membrane protein, integral	P09793	12477	Ctla4		mouse	Y201	PHOSPHORYLATION	450897	SPLTTGVyVKMPPTE		molecular association, regulation; intracellular localization		JAK2(INDUCES); SHP-2(INDUCES)		3206; 3183	4	0	1	Phosphorylation of Y201 in Jurkat cells correlated with cell surface accumulation of CTLA-4.	
RhoGDI alpha	Apoptosis; Cell adhesion; Cell development/differentiation; G protein regulator, misc.; Motility/polarity/chemotaxis	P52565	396	ARHGDIA	17q25.3	human	S101	PHOSPHORYLATION	452195	LESFKKQsFVLKEGV	Rho_GDI	molecular association, regulation		RAC1(DISRUPTS); Cdc42 iso1(DISRUPTS)		12021318	3	4	1		
Cdc25C	EC 3.1.3.48; Motility/polarity/chemotaxis; PHOSPHATASE; Protein phosphatase, dual-specificity	P30307	995	CDC25C	5q31	human	S191	PHOSPHORYLATION	450979	EDQAEEIsDELMEFS	M-inducer_phosp	intracellular localization				3241	1	0	1		
CTNND1	Actin binding protein; Adaptor/scaffold; Cell adhesion; G protein regulator, misc.; Motility/polarity/chemotaxis	P30999	12388	Ctnnd1		mouse	K622	ACETYLATION	3689228	AASCFGAkKGKDEWF			cytoskeletal reorganization			8130	0	1	24		
Snail1	C2H2-type zinc finger protein; Transcription factor	O95863	6615	SNAI1	20q13.2	human	S100	PHOSPHORYLATION	6097704	DEDSGKGsQPPSPPS	CAP_N	protein degradation; ubiquitination; intracellular localization	cell motility, altered; transcription, altered	FBW1B(INDUCES)		6066701; 6098000	3	0	0	Localization mediated by S107, S111, S115 and S119. 	
ITGB2	Cell adhesion; Cell surface; Membrane protein, integral; Motility/polarity/chemotaxis; Receptor, misc.	P05107	3689	ITGB2	21q22.3	human	T760	PHOSPHORYLATION	450185	LFKSATTtVMNPKFA	Integrin_b_cyt	molecular association, regulation		kindlin-3(INDUCES)		28722117	3	0	0		
Lamin B2	Cytoskeletal protein; Motility/polarity/chemotaxis	P14732		LMNB2		chicken	S410	PHOSPHORYLATION	20657002	SSTSLVRsSRGKRRR		intracellular localization				20656300	1	0	0	nuclear uptake inhibited in vitro	
AP2M1	Adaptor/scaffold; Vesicle protein	Q96CW1	1173	AP2M1	3q28	human	T156	PHOSPHORYLATION	448782	SQITSQVtGQIGWRR		molecular association, regulation; intracellular localization		ATP1A1(NOT_REPORTED)		7679; 5736	4	14	25	phosphorylation mediates high-affinity binding of AP-2 to membrane protein sorting signals.; important for endocytosis	
CACNB1	Channel, calcium	P54283	50688	Cacnb1		rat	S161	PHOSPHORYLATION	459045	CEVGFIPsPVKLDSL	SH3_1	activity, induced				7447	1	0	0		
KCNMA1	Channel, potassium; Endoplasmic reticulum; Membrane protein, integral; Membrane protein, multi-pass	Q12791	3778	KCNMA1	10q22.3	human	S1200	PHOSPHORYLATION	9805700	SHSSQSSsKKSSSVH		activity, induced				9689608	1	0	0		
GHF-1	DNA binding protein; Transcription factor	P10037	25517	Pou1f1		rat	T220	PHOSPHORYLATION	451518	RKRKRRTtISIAAKD	Lsr2; Homeobox	molecular association, regulation; activity, inhibited	transcription, inhibited	Ets-1(INDUCES)	DNA(DISRUPTS)	11424216; 3553; 5442	2	0	0	stimulates binding to dimeric, but not to monomeric GHF-1 sites in the rPRL promoter	
UBF	DNA binding protein; Transcription factor	P25976	21429	Ubtf		mouse	S484	PHOSPHORYLATION	450180	DRGKLPEsPKRAEEI			transcription, induced			2817	1	15	59		
MEK1	EC 2.7.12.2; KINASE; Kinase, protein; Protein kinase, STE; Protein kinase, dual-specificity	Q02750	5604	MAP2K1	15q22.1-q22.33	human	S298	PHOSPHORYLATION	448284	RTPGRPLsSYGMDSR	Pkinase	molecular association, regulation	cell growth, altered	ERK1(INDUCES); RAF1(INDUCES)		3342623; 7231; 1164	16	0	0		
ABCA1	Membrane protein, integral; Membrane protein, multi-pass; Transporter; Vesicle protein	P41233	11303	Abca1		mouse	T1286	PHOSPHORYLATION	450308	QSCLHPFtEDDAVDP		protein degradation; protein processing				2926	1	0	0	Mutants showed increase of cell surface protein levels. ; T1286A and T1305A mutants are not degraded by calpain or stabilized by apoA-1. 	
RAF1	EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, Ser/Thr (non-receptor); Protein kinase, TKL	P04049	5894	RAF1	3p25	human	S642	PHOSPHORYLATION	455309	NACTLTTsPRLPVF_		molecular association, regulation; intracellular localization; enzymatic activity, inhibited		HRas(DISRUPTS)		4487	1	7	21		
NCAM1	Cell adhesion; Membrane protein, integral; Motility/polarity/chemotaxis	P13591	4684	NCAM1	11q23.1	human	Y744	PHOSPHORYLATION	454070	VVVDITCyFLNKCGL	Shisa		cell growth, altered			4189	2	0	0	phosphorylation of this residue plays a role in the FGFR1- mediated cell signaling 	
SRC-3	ACETYLTRANSFERASE; Acetyltransferase; EC 2.3.1.48; Motility/polarity/chemotaxis; Nuclear receptor co-regulator; Transcription, coactivator/corepressor	Q9Y6Q9	8202	NCOA3	20q12	human	S601	PHOSPHORYLATION	7596700	SDKESKEsSVEGAEN		protein stabilization	transcription, induced			7543509	1	0	0		
CFLAR	Apoptosis	O15519	8837	CFLAR	2q33-q34	human	S273	PHOSPHORYLATION	7590800	LLRDTFTsLGYEVQK	Peptidase_C14	protein degradation				7543514	1	0	0		
villin	Actin binding protein; Motility/polarity/chemotaxis	P09327	7429	VIL1	2q35	human	Y286	PHOSPHORYLATION	469579	LLSHEDCyILDQGGL	Gelsolin		cell motility, altered; cytoskeletal reorganization			8235	1	0	0		
CRYAB	Chaperone	P02511	1410	CRYAB	11q22.3-q23.1	human	S59	PHOSPHORYLATION	448783	PSFLRAPsWFDTGLS	Crystallin	activity, induced; molecular association, regulation; intracellular localization; protein conformation		CRYAB(DISRUPTS)		1172875; 8402; 5906; 8239; 6695	32	14	0	increased chaperone-like activity and subunit exchange in vitro	
survivin	Apoptosis	O15392	332	BIRC5	17q25	human	T34	PHOSPHORYLATION	447705	FLEGCACtPERMAEA	BIR	activity, induced; protein stabilization; molecular association, regulation; intracellular localization	apoptosis, inhibited; cytoskeletal reorganization; cell growth, altered	Casp9(INDUCES)		6200; 6520; 1290; 5410125; 6309; 6015; 6946; 6155	10	3	5	nuclear and cytopasmic pools of survivin differentially localized and associated with microrubles during mitosis	
Kv7.3 iso2	Channel, potassium; Membrane protein, integral; Membrane protein, multi-pass	O88944-2	29682	Kcnq3		rat	Y67	PHOSPHORYLATION	453408	VKRNNAKyRRIQTLI		activity, inhibited				4129	1	0	0	inhibition of  K(+) current via reducing open probability.	
FLT3	EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Protein kinase, TK; Protein kinase, tyrosine (receptor)	Q00342	14255	Flt3		mouse	Y592	PHOSPHORYLATION	448190	PLDNEYFyVDFRDYE		enzymatic activity, induced				6717	12	0	0		
tau iso8	Cytoskeletal protein	P10636-8	4137	MAPT	17q21.1	human	S293	PHOSPHORYLATION	449327	NVQSKCGsKDNIKHV	Tubulin-binding	molecular association, regulation				19084437	5	0	0	in vitro microtubule binding	
SOS1	Adaptor/scaffold; Guanine nucleotide exchange factor, Ras; Motility/polarity/chemotaxis	Q07889	6654	SOS1	2p21	human	S1178	PHOSPHORYLATION	451315	IMSKHLDsPPAIPPR		molecular association, regulation		Grb2(DISRUPTS)		3524	1	5	0		
DDX5	EC 3.6.1.-; EC 3.6.4.13; Helicase; Nuclear receptor co-regulator; RNA binding protein; RNA splicing; Spliceosome	P17844	1655	DDX5	17q21	human	T564	PHOSPHORYLATION	27156800	SFRTGNPtGTYQNGY	P68HR		apoptosis, induced			27132487	1	0	0		
ER-beta	DNA binding protein; Nuclear receptor	O08537	13983	Esr2		mouse	S105	PHOSPHORYLATION	447914	LYAEPQKsPWCEARS	ERbeta_N; Oest_recep	molecular association, regulation	transcription, altered	SRC-1(INDUCES)		1025500; 2622	4	0	0		
Chk2	EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, CAMK; Protein kinase, Ser/Thr (non-receptor)	O96017	11200	CHEK2	22q12.1	human	T389	PHOSPHORYLATION	981400	RTLCGTPtYLAPEVL	Pkinase	intracellular localization; phosphorylation				15658725	2	1	0	prerequisite for T387 phosphorylation; chromatin targeting of S372, S379, T389, singly and T383/389, T378/S379	
FURIN	Cell surface; EC 3.4.21.75; Membrane protein, integral; Protease; Vesicle protein	P09958	5045	FURIN	15q26.1	human	S773	PHOSPHORYLATION	469742	AWQEECPsDSEEDEG		intracellular localization				12660609	1	6	0	retrieval to the trans-Golgi network	
HEXIM1	Motility/polarity/chemotaxis; Transcription factor	O94992	10614	HEXIM1	17q21.31	human	Y271	PHOSPHORYLATION	2835700	QRDFSETyERYHTES		molecular association, regulation	transcription, altered	CDK9(INDUCES)		6373	2	0	0		
53BP1	Transcription, coactivator/corepressor	Q12888	7158	TP53BP1	15q15-q21	human	S1219	PHOSPHORYLATION	481849	DDTESLHsQGEEEFD			cell cycle regulation			5358610	3	6	12		
BAD	Apoptosis	Q92934	572	BAD	11q13.1	human	S99	PHOSPHORYLATION	447862	PFRGRSRsAPPNLWA	Bcl-2_BAD; Bclx_interact	activity, induced; molecular association, regulation	apoptosis, altered; apoptosis, inhibited; cell growth, altered	14-3-3 beta(INDUCES); 14-3-3 zeta(INDUCES); Bcl-2(DISRUPTS); Bcl-xL(DISRUPTS)		4646621; 15031308; 4647108; 9924201; 4646606; 4646618; 21697400; 7237; 6115915; 22722005; 5285; 4646625; 22463919	112	26	189		
FOXC2	Apoptosis; Cell development/differentiation; DNA binding protein; Transcription factor	Q99958	2303	FOXC2	16q24.1	human	T247	PHOSPHORYLATION	7322584	SPRSAAStPAGSPDG		molecular association, regulation	transcription, altered		DNA(INDUCES)	28129300	1	1	0	implicated in vascular remodeling  in vivo	
C/EBP-beta	DNA binding protein; Motility/polarity/chemotaxis; Transcription factor	P17676	1051	CEBPB	20q13.1	human	S325	PHOSPHORYLATION	11180067	EQLSRELsTLRNLFK	I_LWEQ; Nup54; DivIC; HALZ		transcription, induced			10212801	1	0	0		
NPHP1	Cell adhesion	O15259	4867	NPHP1	2q13	human	S123	PHOSPHORYLATION	26395107	EEEEESEsEDSEDSG		molecular association, regulation; intracellular localization		PACS-1(INDUCES)		25785405	1	0	0		
CTNNB1	Actin binding protein; Cell adhesion; Motility/polarity/chemotaxis; Nuclear receptor co-regulator; Transcription factor	Q02248	12387	Ctnnb1		mouse	T41	PHOSPHORYLATION	447583	GIHSGATtTAPSLSG		protein degradation; ubiquitination				4969204	44	3	0		
PTGER4	GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR	P35408	5734	PTGER4	5p13.1	human	S377	PHOSPHORYLATION	450696	SSAMSGHsRSFISRE		molecular association, regulation		ARRB1(INDUCES)		3068	1	0	0		
BRAF	EC 2.7.1.37; EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, Ser/Thr (non-receptor); Protein kinase, TKL	P15056	673	BRAF	7q34	human	S151	PHOSPHORYLATION	478631	VARSNPKsPQKPIVR		molecular association, regulation	cell growth, altered	RAF1(DISRUPTS)		12025500	2	11	31		
H3	DNA binding protein	P68431	8350	HIST1H3A	6p22.1	human	K80	TRI-METHYLATION	1458614	REIAQDFkTDLRFQS	Histone		cell growth, induced			27257063	10	0	0	indicator of mitosis and tumor cell proliferation	
Ets-1	DNA binding protein; Motility/polarity/chemotaxis; Transcription factor	P13474	396235	ETS1		chicken	S285	PHOSPHORYLATION	449318	QRVPSYDsFDSEDYP		activity, inhibited				3214	3	4	49	The in vitro interaction of  Ets-1 with a high-affinity Ets binding site was assayed with EMSA.	
Bcr	EC 2.7.11.1; GTPase activating protein, Rac/Rho; KINASE; Kinase, protein; Protein kinase, ATYPICAL; Protein kinase, Ser/Thr (non-receptor)	Q6PAJ1	110279	Bcr		mouse	S356	PHOSPHORYLATION	447791	SGQSSRVsPSPTTYR		enzymatic activity, inhibited	cell growth, altered			970041	3	5	58		
JNK2	EC 2.7.11.24; KINASE; Kinase, protein; Protein kinase, CMGC; Protein kinase, Ser/Thr (non-receptor)	Q9WTU6	26420	Mapk9		mouse	T183	PHOSPHORYLATION	447649	ACTNFMMtPYVVTRY	Pkinase	enzymatic activity, induced				6735	58	12	422		
MGMT	Apoptosis; DNA repair; EC 2.1.1.63; Methyltransferase; Nuclear receptor co-regulator	P24528	25332	Mgmt		rat	S204	PHOSPHORYLATION	452629	KPSFESSsPKPSG__		protein stabilization				8642	1	9	0	resistant to proteases in vitro which are increased during DEN-induced hepatocarcinogenesis	
PSEN1	Cell surface; EC 3.4.23.-; Membrane protein, integral; Membrane protein, multi-pass; Mitochondrial; Protease	P49768	5663	PSEN1	14q24.3	human	T354	PHOSPHORYLATION	451669	HLGPHRStPESRAAV	Presenilin	protein stabilization; enzymatic activity, induced				14081215; 3772	2	0	14	Phosphorylation of site stabilizes the C-terminal fragment of PSEN1.; increases gamma-secretase activity	
ARHGEF7	Guanine nucleotide exchange factor, Rac/Rho; Motility/polarity/chemotaxis	Q14155	8874	ARHGEF7	13q34	human	T704	PHOSPHORYLATION	455216	EFASRKStAALEEDA		activity, induced; molecular association, regulation	cytoskeletal reorganization	RAP1GDS1(DISRUPTS)		8922	6	4	1	activates ARHGEF7's exchange activity on Rac1	
CENTG1 iso2	GTPase activating protein, ARF; Motility/polarity/chemotaxis	Q99490-2	116986	AGAP2	12q14.1	human	Y774	PHOSPHORYLATION	467225	QGRTALFyARQAGSQ	Ank_2	protein stabilization	apoptosis, altered			8133	1	0	0		
CENTG1 iso2	GTPase activating protein, ARF; Motility/polarity/chemotaxis	Q99490-2	116986	AGAP2	12q14.1	human	S629	PHOSPHORYLATION	4719772	THLSRVRsLDLDDWP	ArfGap	molecular association, regulation; enzymatic activity, induced	cell growth, altered	NFkB-p105(INDUCES)		6366205	1	4	0	enhances proliferation , foci formation, and tumor progression in prostate cancer cells	
TXA2-R	GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR	P21731	6915	TBXA2R	19p13.3	human	T337	PHOSPHORYLATION	451395	LSLQPQLtQRSGLQ_		receptor desensitization, altered				3597	2	1	0		
TNNI3	Actin binding protein; Motility/polarity/chemotaxis; Motor protein	P19429	7137	TNNI3	19q13.4	human	S42	PHOSPHORYLATION	450690	AKKKSKIsASRKLQL		molecular association, regulation		TNNC1(DISRUPTS)		7362300	18	1	0		
KCNMA1	Channel, potassium; Endoplasmic reticulum; Membrane protein, integral; Membrane protein, multi-pass	Q8AYS8	374065	KCNMA1		chicken	S883	PHOSPHORYLATION	4715384	DRSSPDNsPVHGLLR		intracellular localization; activity, inhibited				22463944	1	4	0		
SOX9	DNA binding protein; Transcription factor	P48436	6662	SOX9	17q23	human	S181	PHOSPHORYLATION	456981	YQPRRRKsVKNGQAE		activity, induced; molecular association, regulation; intracellular localization	transcription, induced; cytoskeletal reorganization	KPNB1(INDUCES)		12558726; 7824; 7889925; 3194	7	1	0		
CSRP2	Cell development/differentiation	Q16527	1466	CSRP2	12q21.1	human	Y57	PHOSPHORYLATION	470028	AIHDEEIyCKSCYGK	LIM	intracellular localization	transcription, altered			8850	1	1	1	Nuclear translocation.	
ADRB2	GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR	P07550	154	ADRB2	5q31-q32	human	Y132	PHOSPHORYLATION	449831	CVIAVDRyFAITSPF	7tm_1	activity, induced				970035	3	0	0	G-protein activation	
Smad1	DNA binding protein; Transcription factor	Q15797	4086	SMAD1	4q31	human	S214	PHOSPHORYLATION	451176	PTSSDPGsPFQMPAD	DUF605	molecular association, regulation; intracellular localization		YAP1(INDUCES)		3385; 12066001	3	0	0		
CRMP-1	Cell development/differentiation; Cytoskeletal protein; Hydrolase	Q14194	1400	CRMP1	4p16.1	human	S522	PHOSPHORYLATION	1295503	PAPSAKSsPSKHQPP			cytoskeletal reorganization			1172844	2	7	7	Phosphorylation induces  increased density of synaptic clusters and neurite projection.  	
occludin	Cell adhesion; Membrane protein, integral; Membrane protein, multi-pass; Motility/polarity/chemotaxis	Q91049		OCLN		chicken	Y379	PHOSPHORYLATION	5393504	PELDESQyETDYTTA		molecular association, regulation; intracellular localization		ZO1(INDUCES)		5354427	1	3	1		
PTP1B	EC 3.1.3.48; Motility/polarity/chemotaxis; PHOSPHATASE; Phosphatase; Protein phosphatase, tyrosine (non-receptor)	P18031	5770	PTPN1	20q13.1-q13.2	human	S50	PHOSPHORYLATION	447811	RNRYRDVsPFDHSRI	Y_phosphatase	molecular association, regulation; enzymatic activity, inhibited; enzymatic activity, induced		InsR(DISRUPTS)		15331016; 1398; 2715	4	3	16		
Mpl	Membrane protein, integral; Receptor, cytokine	Q08351	17480	Mpl		mouse	S550	PHOSPHORYLATION	3091401	SKATVTDsCEEVEPS		activity, induced; phosphorylation	cell growth, altered			8388	1	0	0	tyrosine phosphorylation of JAK2	
p53	Activator protein; DNA binding protein; Motility/polarity/chemotaxis; Nuclear receptor co-regulator; Transcription factor; Tumor suppressor	P04637	7157	TP53	17p13.1	human	K132	UBIQUITINATION	486294	TYSPALNkMFCQLAK	P53	protein degradation; intracellular localization				12136	1	1	0		
Fas	Apoptosis; Cell surface; Membrane protein, integral; Receptor, cytokine	P25445	355	FAS	10q24.1	human	Y232	PHOSPHORYLATION	455221	SDVDLSKyITTIAGV	Peptidase_M73; Death	molecular association, regulation; intracellular localization	apoptosis, altered	Casp8(INDUCES); FADD(INDUCES); Fas(INDUCES)		9149; 4414	2	0	0	Y232 or Y291 is required for Fas oligomerization	
ARHGAP5	GTPase activating protein, Rac/Rho; Motility/polarity/chemotaxis	Q13017	394	ARHGAP5	14q12	human	Y1109	PHOSPHORYLATION	455068	KGYSDEIyVVPDDSQ		activity, induced	cell motility, altered; cell growth, altered			5007918	2	11	166	inhibits Rho activity, activates Ras activity	
GTF2I iso2	DNA binding protein; Transcription, coactivator/corepressor	P78347-2	2969	GTF2I	7q11.23	human	Y357	PHOSPHORYLATION	448251	QSHVEDLyVEGLPEG	GTF2I		transcription, altered			1722	1	1	2		
APOBEC3G	EC 3.5.4.-; Hydrolase; RNA binding protein; RNA processing	Q9HC16	60489	APOBEC3G	22q13.1-q13.2	human	T32	PHOSPHORYLATION	5044101	PILSRRNtVWLCYEV	APOBEC_N	activity, induced; molecular association, regulation; protein conformation				5014003	2	0	0	promotes APOBEC3G anti-viral activity, by inhibiting binding to HIV-1 viral infectivity factor and its subsequent ubiquitination and degradation	
ROMK	Channel, potassium; Membrane protein, integral; Membrane protein, multi-pass	P35560	24521	Kcnj1		rat	S219	PHOSPHORYLATION	2461201	RVANLRKsLLIGSHI	IRK	activity, induced; protein conformation				2451817	5	0	0		
RARG	DNA binding protein; Nuclear receptor	P13631	5916	RARG	12q13	human	S77	PHOSPHORYLATION	455543	SEEMVPSsPSPPPPP		activity, induced	transcription, induced			8768	2	0	0	Transactivation of mRARb2 promoter	
p53	Activator protein; DNA binding protein; Motility/polarity/chemotaxis; Nuclear receptor co-regulator; Transcription factor; Tumor suppressor	P04637	7157	TP53	17p13.1	human	K373	ACETYLATION	458980	SSHLKSKkGQSTSRH		molecular association, regulation	apoptosis, induced; transcription, induced; transcription, altered	TAF1(INDUCES)	DNA(INDUCES)	1908950; 2790309; 7647800	51	3	0	 ; enhances p53-TAF1 complex binding to the p21 promoter; ZNF420 (Apak) represses p53 activity by attenuating its acetylation ;  p53 8KR mutant can be still degraded by Mdm2; p53 8KR mutation (K120/164/370/372/373/381/382/386R) impairs p53-dependent transcription	
TNNI3	Actin binding protein; Motility/polarity/chemotaxis; Motor protein	P23693	29248	Tnni3		rat	T144	PHOSPHORYLATION	451483	RGKFKRPtLRRVRIS	Troponin	activity, inhibited	cytoskeletal reorganization			4313625; 7201	18	1	1	regulates cardiac contractile function; acute acceleration of relaxation	
H3	DNA binding protein	P68431	8350	HIST1H3A	6p22.1	human	K28	TRI-METHYLATION	1308913	LATKAARkSAPATGG			transcription, inhibited			20655004	89	4	3		
Rb-like 2	Transcription, coactivator/corepressor	Q08999	5934	RBL2	16q12.2	human	S1035	PHOSPHORYLATION	449738	NMDAPPLsPYPFVRT		molecular association, regulation	cell cycle regulation	E2F4(DISRUPTS)		1200; 5981	3	4	23		
Smad3	DNA binding protein; Nuclear receptor co-regulator; Transcription factor	P84022	4088	SMAD3	15q22.33	human	S213	PHOSPHORYLATION	451180	NLSPNPMsPAHNNLD		intracellular localization	cell cycle regulation; transcription, inhibited; transcription, altered; cell growth, altered			15658700; 3386; 4092	8	0	0		
PHB	Apoptosis; Cell cycle regulation; Chaperone; Mitochondrial; Motility/polarity/chemotaxis; Transcription, coactivator/corepressor	P35232	5245	PHB	17q21	human	Y259	PHOSPHORYLATION	6374000	SRSRNITyLPAGQSV		O-GlcNAc glycosylation				6331325	3	0	0		
sarcolipin	Endoplasmic reticulum; Membrane protein, integral	Q9CQD6	66402	Sln		mouse	T5	PHOSPHORYLATION	459214	___MERStQELFINF	Sarcolipin; Phospholamban; SecE	molecular association, regulation		SERCA2(INDUCES)		7689	3	0	0		
RAF1	EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, Ser/Thr (non-receptor); Protein kinase, TKL	P05625	396245	RAF1		chicken	S339	PHOSPHORYLATION	447743	PRGQRDSsYYWEIEA		intracellular localization	apoptosis, inhibited			2941	8	1	1		
NKX3-1	DNA binding protein; Transcription factor	Q99801	4824	NKX3-1	8p21.2	human	T93	PHOSPHORYLATION	464288	EAETLAEtEPERHLG	Trypan_PARP	protein stabilization				7864	2	0	0		
CK1E	EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, CK1; Protein kinase, Ser/Thr (non-receptor)	P49674	1454	CSNK1E	22q13.1	human	T337	PHOSPHORYLATION	453419	PGPPTGAtANRLRSA		enzymatic activity, inhibited				8419; 2331	2	0	0	some subset of these 8 sites	
JAK2	EC 2.7.10.2; KINASE; Kinase, protein; Protein kinase, TK; Protein kinase, tyrosine (non-receptor)	Q62120	16452	Jak2		mouse	Y868	PHOSPHORYLATION	470141	GSVEMCRyDPLQDNT	Pkinase_Tyr	enzymatic activity, induced				13354701	3	2	0		
DAP3	Apoptosis; Mitochondrial; Nuclear receptor co-regulator	P51398	7818	DAP3	1q22	human	S251	PHOSPHORYLATION	2226201	LKELKRQsSLGMFHL	DAP3		apoptosis, induced			2195711	1	1	0		
GRK1	EC 2.7.11.14; KINASE; Kinase, protein; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor)	Q15835	6011	GRK1	13q34	human	S21	PHOSPHORYLATION	456353	AFIAARGsFDGSSSQ		enzymatic activity, inhibited				6682	3	0	1	reaction in vitro	
doublecortin	Cytoskeletal protein; Motility/polarity/chemotaxis	O88809	13193	Dcx		mouse	S297	PHOSPHORYLATION	451111	PQKTSAKsPGPMRRS			cytoskeletal reorganization	CDK5(DISRUPTS)		1193012; 3310	5	1	4		
BAG3	Apoptosis	O95817	9531	BAG3	10q25.2-q26.2	human	S187	PHOSPHORYLATION	12217052	SSSSSSAsLPSSGRS			cell motility, induced			27132441	1	1	0	involved in epithelial-mesenchymal transition (EMT);  promotes migration and invasion of FRO cells	
BRCA1	EC 6.3.2.-; Nuclear receptor co-regulator; Transcription, coactivator/corepressor; Tumor suppressor; UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase	P38398	672	BRCA1	17q21	human	S1143	PHOSPHORYLATION	767900	PMGSSHAsQVCSETP		intracellular localization				762701	1	0	0	S1143 and S1280 phosphorylation contributes to BRCA1 recruitment to MMTS-induced foci. 	
SLC12A3	Membrane protein, integral; Membrane protein, multi-pass; Transporter	P55018	54300	Slc12a3		rat	T58	PHOSPHORYLATION	469617	LRTFGYNtIDVVPAY	AA_permease_N	activity, induced; intracellular localization				27132423; 14562604	14	3	0		
Rab4	G protein; G protein, monomeric, Rab	P20338	5867	RAB4A	1q42-q43	human	S199	PHOSPHORYLATION	451289	AALRQLRsPRRAQAP		intracellular localization				3508	1	0	0	S199 phosphorylation was required for the accumulation of rab4 in the cytosol of mitotic cells.	
IkB-epsilon	DNA binding protein; Inhibitor protein	O54910	18037	Nfkbie		mouse	S22	PHOSPHORYLATION	455581	QCDSGIEsLRSLRSL		protein degradation				5520	2	0	0		
PSEN1	Cell surface; EC 3.4.23.-; Membrane protein, integral; Membrane protein, multi-pass; Mitochondrial; Protease	P49768	5663	PSEN1	14q24.3	human	S357	PHOSPHORYLATION	448563	PHRSTPEsRAAVQEL	Presenilin	molecular association, regulation; intracellular localization; protein conformation	cell growth, altered	CTNNB1(DISRUPTS); CDH2(DISRUPTS); CTNNB1(INDUCES)		9615; 9608; 1674	3	0	2	;  GSK3beta activation downregulates PI3K/Akt signaling probably by reducing the interaction of PSEN1 with N-cadherin (CDH2)/ beta catenin (CTNNB1); reduced interaction was observed in the constitutively active GSK3beta (S9A) mutant; stabilizes beta catenin by reducing its ubiquitination and turn-over 	
Ron	EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Protein kinase, TK; Protein kinase, tyrosine (receptor)	Q04912	4486	MST1R	3p21.3	human	S1394	PHOSPHORYLATION	450270	VRRPRPLsEPPRPT_		molecular association, regulation		14-3-3 beta(INDUCES)		2984; 2975	2	2	22		
IP3R1	Channel, calcium; Channel, ligand-gated; Membrane protein, integral; Membrane protein, multi-pass; Receptor, misc.	Q14643	3708	ITPR1	3p26.1	human	Y353	PHOSPHORYLATION	450970	NAQEKMVySLVSVPE	MIR	activity, induced; receptor desensitization, altered	transcription, altered		Other(NOT_REPORTED)	3237; 3433205	3	0	0		
KCNJ8	Channel, potassium; Membrane protein, integral; Membrane protein, multi-pass	Q63664	25472	Kcnj8		rat	S354	PHOSPHORYLATION	1458600	RVAAPRCsARELDEK	IRK	activity, inhibited				1172871	1	0	0		
ephexin-1 iso2	Guanine nucleotide exchange factor, Rac/Rho	Q8CHT1-2	53972	Ngef		mouse	Y87	PHOSPHORYLATION	455579	IEQIGLLyQEYRDKS			cytoskeletal reorganization			13354738	4	0	2	disperse of AChR clusters	
JAK3	EC 2.7.10.2; KINASE; Kinase, protein; Protein kinase, TK; Protein kinase, tyrosine (non-receptor)	P52333	3718	JAK3	19p13.1	human	Y939	PHOSPHORYLATION	2197000	QICKGMEyLGSRRCV	Pkinase_Tyr	molecular association, regulation; phosphorylation; enzymatic activity, induced		STAT5A(INDUCES)		2195702	1	0	0	possible docking site for kinase substrates; required for STAT5A Y694 phosphorylation and its further transcriptional activation	
SLC4A4	Membrane protein, integral; Membrane protein, multi-pass; Transporter	Q9Y6R1	8671	SLC4A4	4q21	human	T49	PHOSPHORYLATION	13194700	RRRHKRKtGHKEKKE		activity, induced				12660600	2	0	0	S1026 phosphorylation alters stoichiometry shift, while T49 mediates increase in membrane conductance.	
NMDAR2B	Channel, calcium; Channel, ligand-gated; Membrane protein, integral; Membrane protein, multi-pass	Q13224	2904	GRIN2B	12p12	human	S1303	PHOSPHORYLATION	450171	NKLRRQHsYDTFVDL	NMDAR2_C	molecular association, regulation		CAMK2A(DISRUPTS)		7910513	20	9	12	Ca2+ -independent binding	
GTF2A1	Transcription, coactivator/corepressor	P52655	2957	GTF2A1	14q31.1	human	S280	PHOSPHORYLATION	449822	VDGTGDTsSEEDEDE	TFIIA; Syndecan		transcription, induced			1829	1	0	0		
NR1D1	Nuclear receptor; Transcription factor	P20393	9572	NR1D1	17q11.2	human	S59	PHOSPHORYLATION	471092	FPPSPTGsLTQDPAR		protein stabilization				12525200	1	0	0		
BVR	Cofactor and Vitamin Metabolism - porphyrin and chlorophyll; EC 1.3.1.24; KINASE; Kinase, protein; Oxidoreductase; Protein kinase, Ser/Thr (non-receptor)	P53004	644	BLVRA	7p13	human	Y198	PHOSPHORYLATION	455758	EERKEDQyMKMTVCL	Biliv-reduc_cat	enzymatic activity, induced				5811	1	0	1	phosphorylation enhances BVR's antagonism of insulin-stimulated glucose uptake.	
PTPRT iso1	EC 3.1.3.48; Membrane protein, integral; Motility/polarity/chemotaxis; PHOSPHATASE; Receptor protein phosphatase, tyrosine	O14522-1	11122	PTPRT	20q12-q13	human	Y915	PHOSPHORYLATION	11315001	GYGFKEEyEALPEGQ		molecular association, regulation; enzymatic activity, inhibited	cell growth, altered	PTPRT iso1(INDUCES); NLGN1(DISRUPTS)		11189908	1	0	0	attenuates synapse formation	
CCNB1	Activator protein; Cell cycle regulation	P14635	891	CCNB1	5q12	human	S147	PHOSPHORYLATION	448446	EDLCQAFsDVILAVN		intracellular localization			DNA(INDUCES)	25573559; 1463; 12778806	6	1	0	The phosphorylation of S133 and S147 is necessary for the nuclear translocation of cyclin B1 during G2/M phase.; enhances nuclear import	
CELF2 iso3	RNA binding protein	Q792H5-3	29428	Celf2		rat	Y39	PHOSPHORYLATION	463177	LKELFEPyGAVYQIN	RRM_1	molecular association, regulation			RNA(INDUCES)	762722	1	0	4		
IFNAR2	Membrane protein, integral; Receptor, cytokine	P48551	3455	IFNAR2	21q22.11	human	Y337	PHOSPHORYLATION	3063305	PRTSGGGyTMHGLTV		activity, induced; phosphorylation	transcription, induced; transcription, altered			12028127; 25779402; 8565	3	0	0	STAT phosphorylation and activation; lack of STAT1, 2, 3 phosphorylation in IFNAR2 Y337/512F mutant; IFN induced STAT activation and induced transcription 	
cortactin	Actin binding protein; Cytoskeletal protein; Motility/polarity/chemotaxis	O70420	60465	Cttn		rat	Y444	PHOSPHORYLATION	447704	YQAEDDTyDGYESDL			cell adhesion, altered			8393	16	1	3		
NSF	Adaptor/scaffold; Autophagy; EC 3.6.4.6; Protease; Vesicle protein	P46460	18195	Nsf		mouse	S460	PHOSPHORYLATION	15794301	MNRHIKAsTKVEVDM		intracellular localization; enzymatic activity, induced				15755113	1	0	0		
HSP27	Chaperone; Motility/polarity/chemotaxis	P04792	3315	HSPB1	7q11.23	human	S82	PHOSPHORYLATION	448403	RALSRQLsSGVSEIR		protein degradation; molecular association, regulation; phosphorylation; activity, induced; sumoylation; ubiquitination; intracellular localization; protein conformation	apoptosis, altered; apoptosis, inhibited; cytoskeletal reorganization; transcription, altered; cell growth, altered	TRAF6(DISRUPTS); TPM1(INDUCES); hnRNP D0(DISRUPTS); HSF1(DISRUPTS); Akt1(DISRUPTS)		7229; 5583; 21261102; 6804602; 1122; 4280504; 7325707; 8471500; 1959; 5892	44	56	263	Raf/MEK/ERK and p38/MKP-1 phosphorylation	
CREB	DNA binding protein; Transcription factor	P15337	81646	Creb1		rat	S142	PHOSPHORYLATION	448547	RKILNDLsSDAPGVP	pKID	molecular association, regulation; activity, inhibited	transcription, inhibited	CBP(DISRUPTS); CREB(DISRUPTS)		2736; 1716; 3899	10	10	2		
MYPT1	Motility/polarity/chemotaxis; Protein phosphatase, regulatory subunit	O14974	4659	PPP1R12A	12q15-q21	human	T696	PHOSPHORYLATION	448587	ARQSRRStQGVTLTD		intracellular localization				7007	49	15	213		
gp130	Membrane protein, integral; Receptor, cytokine	P40189	3572	IL6ST	5q11.2	human	Y905	PHOSPHORYLATION	448182	DEGMPKSyLPQTVRQ			cell cycle regulation; transcription, altered			1364	2	2	15		
SLC3A2	Membrane protein, integral; Transporter	P08195	6520	SLC3A2	11q13	human	S410	PHOSPHORYLATION	6003502	SYLSDSGsTGEHTKS			cell adhesion, altered			5930022	1	0	0	enhances cell- cell interactions	
SREBP-1	DNA binding protein; Membrane protein, integral; Membrane protein, multi-pass; Transcription factor	P36956	6720	SREBF1	17p11.2	human	S338	PHOSPHORYLATION	458357	IEKRYRSsINDKIIE	HLH	molecular association, regulation	transcription, inhibited	SREBP-1(DISRUPTS)		7368	2	0	0	inhibits lipogenesis	
H3	DNA binding protein	P68433	360198	Hist1h3a		mouse	K15	ACETYLATION	458954	ARKSTGGkAPRKQLA		molecular association, regulation	transcription, altered		DNA(INDUCES)	7124718; 15031328	111	8	339	T gondii infection inhibited H3-mediated TNF transcription.	
DAT	Membrane protein, integral; Membrane protein, multi-pass; Transporter	Q01959	6531	SLC6A3	5p15.3	human	S2	PHOSPHORYLATION	451135	______MsKSKCSVG		activity, induced				8183	2	0	0	stimulates DAT-mediated efflux of dopamine	
PAK3	EC 2.7.1.; EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, STE; Protein kinase, Ser/Thr (non-receptor)	Q62829	29433	Pak3		rat	T421	PHOSPHORYLATION	448126	PEQSKRStMVGTPYW	Pkinase	enzymatic activity, induced				738	3	2	9		
ARHGEF1	Guanine nucleotide exchange factor, Rac/Rho; Motility/polarity/chemotaxis	Q92888	9138	ARHGEF1	19q13.13	human	Y738	PHOSPHORYLATION	13421400	WDQEAQIyELVAQTV		activity, induced				13354713	1	0	0		
FcRL3	Adaptor/scaffold; Membrane protein, integral	Q96P31	115352	FCRL3	1q21-q22	human	Y650	PHOSPHORYLATION	469980	PMELEPMySNVNPGD		molecular association, regulation		ZAP70(INDUCES)		8823	1	0	0		
Fas	Apoptosis; Cell surface; Membrane protein, integral; Receptor, cytokine	P25445	355	FAS	10q24.1	human	Y91	PHOSPHORYLATION	473547	PCQEGKEyTDKAHFS	TNFR_c6	intracellular localization	apoptosis, altered			9149	2	0	0		
SLC25A4	Membrane protein, integral; Membrane protein, multi-pass; Mitochondrial; Transporter	P12235	291	SLC25A4	4q35	human	Y195	PHOSPHORYLATION	457913	RAAYFGVyDTAKGML	Mito_carr; TM		cell growth, altered			12021334	1	9	236	required for an efficient oxidative growth in yeast 	
SGK3	EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor)	Q96BR1	23678	SGK3	8q12	human	S486	PHOSPHORYLATION	448196	DDAFVGFsYAPPSED	Pkinase_C	molecular association, regulation; enzymatic activity, induced		PDK1(INDUCES); ITCH(INDUCES)		25779405; 7222	4	0	0	CISK interaction with ITCH inhibits CXCR4 degradation.	
NR2C1	DNA binding protein; Nuclear receptor	Q505F1	22025	Nr2c1		mouse	K238	SUMOYLATION	4258801	NIHPSGIkTEPAMLM		activity, inhibited	transcription, altered			4042510	2	0	0		
ARHGAP12	GTPase activating protein, Rac/Rho	Q8C0D4	75415	Arhgap12		mouse	T229	PHOSPHORYLATION	451930	TEQMRATtPPNQGRP			cell cycle regulation; cell motility, altered			2790302	0	16	41		
Bcl-2	Apoptosis; Autophagy; Membrane protein, integral	P49950	24224	Bcl2		rat	S70	PHOSPHORYLATION	448395	RDTAARTsPLRPLVA			apoptosis, altered			6757; 5759	35	1	0		
APBA2	Adaptor/scaffold	Q99767	321	APBA2	15q11-q12	human	S238	PHOSPHORYLATION	7151800	AEIKMSLsMTSITSA		molecular association, regulation		APP(INDUCES)		6829235	1	0	0		
RAF1	EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, Ser/Thr (non-receptor); Protein kinase, TKL	P04049	5894	RAF1	3p25	human	S621	PHOSPHORYLATION	447746	PKINRSAsEPSLHRA		molecular association, regulation; enzymatic activity, inhibited; protein conformation; phosphorylation; enzymatic activity, induced	cell growth, altered	14-3-3 beta(INDUCES); 14-3-3 zeta(INDUCES)		5121521; 8397; 12068402; 6115934; 1851; 12025500	22	35	9		
Gab2	Adaptor/scaffold	Q9UQC2	9846	GAB2	11q14.1	human	Y584	PHOSPHORYLATION	448385	SGDSEENyVPMQNPV		molecular association, regulation		PIK3R1(INDUCES)		6227	1	0	0		
Cdc25A	EC 3.1.3.48; Motility/polarity/chemotaxis; PHOSPHATASE; Protein phosphatase, dual-specificity	P48964	12530	Cdc25a		mouse	S74	PHOSPHORYLATION	449340	SSLQRMGsSESTDSG		protein degradation	cell cycle regulation; apoptosis, altered			4835200	10	0	1		
CFTR	Channel, chloride; EC 3.6.3.49; Hydrolase; Membrane protein, integral; Membrane protein, multi-pass; Transporter	P26361	12638	Cftr		mouse	S670	PHOSPHORYLATION	3333405	TETLRRFsVDDSSAP	CFTR_R	protein conformation				11424200	2	1	0	in vitro	
Dok1	Adaptor/scaffold; Motility/polarity/chemotaxis	Q99704	1796	DOK1	2p13	human	S446	PHOSPHORYLATION	454884	SGIKSHNsALYSQVQ		phosphorylation	cell motility, altered; cell growth, altered			4367	1	0	20		
Per2	Transcription factor	O15055	8864	PER2	2q37.3	human	S662	PHOSPHORYLATION	449331	ALPGKAEsVASLTSQ		protein stabilization; intracellular localization; phosphorylation	transcription, induced			20655001; 9256	3	1	1	Phosphorylation of S662 promotes casein kinase I to phosphorylate nearby residues. CKI does not appear to phosphorlyate this residue (requires priming kinase).  Phosphorylation increased period length (tau).  Nonphosphorylated protein is mainly nuclear (as opposed to nuclear and cytoplasmic). Phosphorylated Per2 promotes its own transcription.; Phosphorylation occurs during the circadium cycle.	
BARD1	EC 6.3.2.-; EC 6.3.2.19; Ligase; Tumor suppressor; UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase	Q99728	580	BARD1	2q34-q35	human	S251	PHOSPHORYLATION	455769	SQPSVISsPQINGEI			cell cycle regulation			5849	2	1	1	resistance to genotoxic stress (mitomycin C)	
syntaphilin	Membrane protein, integral; Vesicle protein	AAI39793	241727	Snph		mouse	S71	PHOSPHORYLATION	451012	PPLTRTRsLMAMSLQ		molecular association, regulation		STX1A(DISRUPTS)		3262	1	0	0		
4E-BP1	Translation; Translation initiation	Q13541	1978	EIF4EBP1	8p12	human	S65	PHOSPHORYLATION	447527	FLMECRNsPVTKTPP	eIF_4EBP	molecular association, regulation; protein conformation; activity, inhibited; phosphorylation	translation, altered	eIF4E(DISRUPTS)		4805; 444; 29676408; 17613015	60	27	7	4E-BP1 disassociates from eIF-4E during mitosis, when 4E-BP1 is phosphorylated at S64 and T69. ; T41 and T50 phosphorylation is required for stepwise phosphorylation of T37, T46, S65, and S70; modulates folding and free energy of binding to eiF4E	
GAPDH	Carbohydrate Metabolism - glycolysis and gluconeogenesis; EC 1.2.1.12; EC 2.6.99.-; Oxidoreductase	P04406	2597	GAPDH	12p13	human	Y42	PHOSPHORYLATION	450511	DPFIDLNyMVYMFQY	Gp_dh_N	intracellular localization		PKCI(INDUCES)		11773	1	2	4	membrane association, Beta-COP recruitment, and vesicle formation;  ER to Golgi transport	
PLXNB1	Membrane protein, integral; Motility/polarity/chemotaxis; Receptor, misc.	O43157	5364	PLXNB1	3p21.31	human	Y1708	PHOSPHORYLATION	3413438	DSVGEPLyMLFRGIK	Plexin_cytopl	molecular association, regulation	cell motility, altered	PLCG2(INDUCES); PLCG1(INDUCES); Grb2(INDUCES)		11419367	1	1	2		
Cdc27	Cell cycle regulation	P30260	996	CDC27	17q21.32	human	S154	PHOSPHORYLATION	18258506	FLWSPFEsLCEIGEK			cell growth, altered			18021005	1	0	0	regulates SnoN degradation	
FOXL2	DNA binding protein; Transcription factor	P58012	668	FOXL2	3q23	human	S33	PHOSPHORYLATION	21697903	EPEGPPPsPGKGGGG		intracellular localization				21683740	1	3	1		
LRP2	Membrane protein, integral; Motility/polarity/chemotaxis; Receptor, misc.	P98164	4036	LRP2	2q31.1	human	S4627	PHOSPHORYLATION	767903	PAKPKPPsRRDPTPT		receptor internalization, altered; receptor recycling, altered				762703	1	2	0		
NOX5 iso4	EC 1.6.3.-; Membrane protein, integral; Membrane protein, multi-pass; Oxidoreductase	Q96PH1-4	79400	NOX5	15q23	human	S498	PHOSPHORYLATION	472626	RSVTMRKsQRSSKGS	FAD_binding_8	enzymatic activity, induced				9185; 18415108	3	0	0		
calmodulin	Calcium-binding protein	P62161	24242	Calm1		rat	S102	PHOSPHORYLATION	448706	KDGNGYIsAAELRHV	DUF2267; DUF1103; TerB; EF_hand_5; UPF0154	activity, inhibited				1876	5	13	38	Calmodulin phosphorylated by CKII in vitro showed reduced activation of erythrocyte plasma membrane Ca2+ pump.	
NKEF-A	EC 1.11.1.15; Oxidoreductase	Q06830	5052	PRDX1	1p34.1	human	T90	PHOSPHORYLATION	455554	CHLAWVNtPKKQGGL	AhpC-TSA	molecular association, regulation; enzymatic activity, inhibited; protein conformation		NKEF-A(INDUCES)		27619320; 5438; 2865405	3	1	0		
PTEN	Carbohydrate Metabolism - inositol phosphate; EC 3.1.3.16; EC 3.1.3.48; EC 3.1.3.67; Motility/polarity/chemotaxis; Nuclear receptor co-regulator; PHOSPHATASE; Phosphatase, lipid; Tumor suppressor	P60484	5728	PTEN	10q23.3	human	K254	SUMOYLATION	28722900	LPVCGDIkVEFFHKQ	PTEN_C2	intracellular localization				28722410	1	1	0	nuclear localization retention	
BEST1	Channel, chloride; Membrane protein, integral; Membrane protein, multi-pass	O76090	7439	BEST1	11q13	human	S358	PHOSPHORYLATION	9720901	SAQFRRAsFMGSTFN		activity, induced				9689602	1	0	0	S358E mutation prevents channel rundown 	
CARM1	EC 2.1.1.-; EC 2.1.1.125; METHYLTRANSFERASE; Methyltransferase; Methyltransferase, protein arginine; Nuclear receptor co-regulator	Q9WVG6	59035	Carm1		mouse	S229	PHOSPHORYLATION	486445	HAEVLVKsNNLTDRI	PRMT5	molecular association, regulation; enzymatic activity, inhibited	transcription, inhibited	CARM1(DISRUPTS)		12165	1	0	0		
GLI1	C2H2-type zinc finger protein; Transcription factor	P08151	2735	GLI1	12q13.2-q13.3	human	T304	PHOSPHORYLATION	27708600	GEKPHKCtFEGCRKS	zf-H2C2_2		cell growth, induced; transcription, induced		DNA(INDUCES)	27619353	1	0	0		
SNCA	Adaptor/scaffold	O55042	20617	Snca		mouse	S129	PHOSPHORYLATION	448278	SEAYEMPsEEGYQDY	Synuclein	protein stabilization; molecular association, regulation		ubiquitin(INDUCES)		1173016	31	4	0	Stabilization is in aggregates akin to Lewy Bodies	
TPT1	Calcium-binding protein; Microtubule binding protein	P63028	22070	Tpt1		mouse	S64	PHOSPHORYLATION	3146607	PEGEGTEsTVVTGVD	TCTP		cell cycle regulation; apoptosis, inhibited; cytoskeletal reorganization			3150500	1	0	0		
FGD1	Guanine nucleotide exchange factor, misc.	P52734	14163	Fgd1		mouse	S205	PHOSPHORYLATION	3193805	LVPRAEAsTSSAAVS		intracellular localization	cytoskeletal reorganization			12558745	2	1	0		
MCM2	DNA binding protein; EC 3.6.4.12	P49736	4171	MCM2	3q21	human	S5	PHOSPHORYLATION	2201405	___MAESsESFTMAS		intracellular localization				9985932	2	1	0	promotes Mcm2 loading onto chromatin	
PAK1	EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, STE; Protein kinase, Ser/Thr (non-receptor)	O88643	18479	Pak1		mouse	S21	PHOSPHORYLATION	448174	APPMRNTsTMIGAGS		activity, induced; molecular association, regulation; intracellular localization		Nck1(DISRUPTS)		5668	3	0	10		
STAT5B	DNA binding protein; Transcription factor	P42232	20851	Stat5b		mouse	S730	PHOSPHORYLATION	448751	TYMDQAPsPVVCPQA		activity, induced				5415	10	0	0		
TH	Amino Acid Metabolism - tyrosine; EC 1.14.16.2; Endoplasmic reticulum; Mitochondrial; Oxidoreductase; Vesicle protein	P04177	25085	Th		rat	S19	PHOSPHORYLATION	448542	KGFRRAVsEQDAKQA	TOH_N; Chorion_2	protein stabilization; molecular association, regulation; protein conformation; enzymatic activity, induced		14-3-3 theta(INDUCES)		4592; 802; 4082; 3058; 1307; 803	33	4	3	Phosphorylation of S8  S19 and S31 (more stable) may stabilize TH already phosphorylated at S40 (least stable).	
EGFR	EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Protein kinase, TK; Protein kinase, tyrosine (receptor)	Q01279	13649	Egfr		mouse	Y1172	PHOSPHORYLATION	448059	MSLDNPDyQQDFFPK		enzymatic activity, induced				8282	33	32	946		
SCN2A	Channel, sodium; Membrane protein, integral; Membrane protein, multi-pass	P04775	24766	Scn2a		rat	Y66	PHOSPHORYLATION	1046203	GKSLPFIyGDIPPEM		molecular association, regulation; activity, inhibited		Fyn(INDUCES)		970058	1	0	0		
Myc	DNA binding protein; Transcription factor	P01106	4609	MYC	8q24.21	human	S71	PHOSPHORYLATION	449991	SRRSGLCsPSYVAVT	Myc_N	protein stabilization	apoptosis, altered; apoptosis, induced			6460; 2540	4	3	0		
CACNA1C	Channel, calcium; Membrane protein, integral; Membrane protein, multi-pass	Q13936	775	CACNA1C	12p13.3	human	Y1920	PHOSPHORYLATION	1043300	ETSQDETyEVKMNHD		activity, induced				970052	2	0	1	Ca(2+) currents	
MAZ	C2H2-type zinc finger protein; Transcription factor	P56270	4150	MAZ	16p11.2	human	T72	PHOSPHORYLATION	451250	AAPAPPPtPQAPAAE		activity, induced	transcription, induced			3472	1	0	0		
calsenilin	Calcium-binding protein; Transcription factor	Q9Y2W7	30818	KCNIP3	2q21.1	human	S63	PHOSPHORYLATION	450214	APQGSDSsDSELELS		protein processing				2909	1	0	0	Phosphorylation of calsenilin at Ser-63 inhibits cleavage of the molecule by caspase-3.	
SYP	Membrane protein, integral; Membrane protein, multi-pass; Vesicle protein	P07825	24804	Syp		rat	Y273	PHOSPHORYLATION	10769104	QGGYQPDyGQPASGG		molecular association, regulation		Lyn(INDUCES); Src(INDUCES)		27132405	0	1	0		
RNF12	EC 6.3.2.-; Ligase; Transcription, coactivator/corepressor; UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase	Q9WTV7	19820	Rlim		mouse	S214	PHOSPHORYLATION	18014966	QRRARSRsPEHRRTR		intracellular localization	cell motility, induced; apoptosis, inhibited			28722419	1	0	0	phosphorylated S214 (human) or S215 (murine) RNF12 is localized in nucleus;  shuttling of RNF12 is important for promoting cell motility and alveolar cell survival	
Casp9	Apoptosis; EC 3.4.22.62; Protease	P55211	842	CASP9	1p36.21	human	S196	PHOSPHORYLATION	448454	KLRRRFSsLHFMVEV	Peptidase_C14	activity, inhibited	apoptosis, induced			1004	2	1	0		
SLC5A5	Membrane protein, integral; Membrane protein, multi-pass; Transporter	Q63008	114613	Slc5a5		rat	S581	PHOSPHORYLATION	990309	DTATLEEsLVKGPED		activity, induced				970026	1	1	0		
GLP1R	GPCR, family 2; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR	P32301	25051	Glp1r		rat	S444	PHOSPHORYLATION	451382	KCPTSSVsSGATVGS		receptor desensitization, altered				3574	1	0	0		
CACNG2	Channel, calcium; Membrane protein, integral; Membrane protein, multi-pass	O88602	12300	Cacng2		mouse	S247	PHOSPHORYLATION	455319	SSRSTEPsHSRDASP	Tetraspannin	activity, induced; intracellular localization				22913905; 4485	1	0	0	AMPAR immobilization in synaptic membrane; enhances AMPA receptor responses and is required for long-term potentiation	
CYP3A4	Cell surface; Cofactor and Vitamin Metabolism - retinol; EC 1.14.13.-; EC 1.14.13.32; EC 1.14.13.67; EC 1.14.13.97; EC 1.14.14.1; Lipid Metabolism - linoleic acid; Membrane protein, integral; Oxidoreductase; Xenobiotic Metabolism - drug metabolism - cytochrome P450; Xenobiotic Metabolism - drug metabolism - other enzymes; Xenobiotic Metabolism - metabolism by cytochrome P450	P08684	1576	CYP3A4	7q21.1	human	S478	PHOSPHORYLATION	5938006	TQIPLKLsLGGLLQP	p450	protein degradation; ubiquitination				5930038; 22463923	2	2	0		
FAK iso3	EC 2.7.1.112; EC 2.7.10.2; KINASE; Kinase, protein; Protein kinase, TK; Protein kinase, tyrosine (non-receptor)	P34152-3	14083	Ptk2		mouse	Y397	PHOSPHORYLATION	447887	SVSETDDyAEIIDEE		activity, induced; protein degradation; molecular association, regulation; phosphorylation; enzymatic activity, induced	cell motility, altered; cytoskeletal reorganization; cell adhesion, altered; transcription, altered; cell growth, altered	Shc1(INDUCES); Src(INDUCES); P130Cas(INDUCES); SOCS3(INDUCES); SOCS1(INDUCES); Arp3(DISRUPTS); Grb2(INDUCES)		2868; 2316; 13270517; 3256104; 2886; 1159301; 2871	234	21	470	MMP-9 production; delayed cell spreading and abnormal lamellipodia in Y397 deletion mutant	
MOR-1	GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR	P35372	4988	OPRM1	6q24-q25	human	T372	PHOSPHORYLATION	447785	STRIRQNtRDHPSTA		receptor internalization, altered				2831776	13	2	0		
NGFR	Membrane protein, integral; Receptor, misc.	P18519		NGFR		chicken	S266	PHOSPHORYLATION	9993601	IAFKRWNsCKQNKQG	DUF2133	protein stabilization				9980416	1	1	0		
RA70	Adaptor/scaffold	O75563	8935	SKAP2	7p15.2	human	Y75	PHOSPHORYLATION	449669	DAEDGEEyDDPFAGP	RICH	protein conformation				21683738	1	3	3		
EPRS	Cofactor and Vitamin Metabolism - porphyrin and chlorophyll; EC 6.1.1.15; EC 6.1.1.17; Ligase; Translation	P07814	2058	EPRS	1q41	human	S886	PHOSPHORYLATION	452230	LSQSSDSsPTRNSEP		molecular association, regulation; phosphorylation	translation, altered	NSAP1(INDUCES); GAPDH(INDUCES); RPL13A(INDUCES)		18021015; 9689600	3	29	6	stimulates EPRS S999 phosphorylation; stimulates phosphorylation of S999	
HRI	EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor); Translation	Q9Z2R9	15467	Eif2ak1		mouse	T490	PHOSPHORYLATION	447596	THTSRVGtCLYASPE	Pkinase	phosphorylation				2258	1	0	0		
H3	DNA binding protein	P68431	8350	HIST1H3A	6p22.1	human	K10	MONO-METHYLATION	1458609	RTKQTARkSTGGKAP			cell cycle regulation			15022717	30	3	0		
ITGB7	Cell adhesion; Membrane protein, integral; Motility/polarity/chemotaxis; Receptor, misc.	P26010	3695	ITGB7	12q13.13	human	Y758	PHOSPHORYLATION	469602	EIYDRREySRFEKEQ	Integrin_b_cyt		cell adhesion, altered			8233	1	0	0		
p21Cip1	Cell cycle regulation; Inhibitor protein	P38936	1026	CDKN1A	6p21.2	human	S130	PHOSPHORYLATION	455618	SGEQAEGsPGGPGDS		protein degradation; molecular association, regulation; protein stabilization; ubiquitination; intracellular localization	cell cycle regulation	CDK2(DISRUPTS); CCND1(DISRUPTS)		1962906; 8698; 6359; 7601400; 22736112	8	4	0		
p53	Activator protein; DNA binding protein; Motility/polarity/chemotaxis; Nuclear receptor co-regulator; Transcription factor; Tumor suppressor	P13481		TP53		monkey	S15	PHOSPHORYLATION	447490	PSIEPPLsQETFSDL	P53_TAD	molecular association, regulation		BLM(INDUCES); Rad51(INDUCES); ATRX(INDUCES); MRE11A(INDUCES)		6133	347	2	0		
CACNB2	Channel, calcium	Q8VGC3	116600	Cacnb2		rat	S529	PHOSPHORYLATION	451398	KKSQHRSsSATHQNH		activity, induced				10274622	5	0	0		
AurC iso2	EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor)	Q9UQB9-2	6795	AURKC	19q13.43	human	T164	PHOSPHORYLATION	455456	TPSLRRKtMCGTLDY	Pkinase	enzymatic activity, induced				5225	2	5	64	T164A mutant showed decreased kinase activity in vitro.	
Smad2	DNA binding protein; Transcription factor	Q15796	4087	SMAD2	18q21.1	human	S465	PHOSPHORYLATION	447494	SPSVRCSsMS_____		activity, induced; molecular association, regulation; intracellular localization	transcription, induced; transcription, altered	Smad4(INDUCES); TGFBR1(DISRUPTS)		814; 7324132; 2448; 5309416	28	0	5	nuclear localization; S464 not likely phosphorylated but is required for efficient phosphorylation of COOH terminus.	
Bcl-10	Apoptosis; Transcription, coactivator/corepressor	O95999	8915	BCL10	1p22	human	S218	PHOSPHORYLATION	469572	EEGTCANsSEMFLPL		molecular association, regulation; intracellular localization		Bcl-3(INDUCES)		8297	3	0	0		
NCAPH	Cell cycle regulation	Q15003	23397	NCAPH	2q11.2	human	S570	PHOSPHORYLATION	470129	PGLQAADsDDEDLDD	Cnd2	phosphorylation	chromatin organization, altered			9061	1	1	3	The phosphorylation of this site was half as strong in mitosis as compared to interphase NCAPH. This CK2 mediated site was dephosphorylated efficiently only on mitotic chromosomes.Dephosphorylation also occured using purified human condensin with Xenopus egg extract. Dephosphorylation of CK2 specific sites greatly increases supercoiling activity of NCAPH. Chromosome length in CK2 supplemented extracts was two-fold longer than in control extracts. 	
INCENP	Cell cycle regulation; EC 2.7.11.1	Q9WU62	16319	Incenp		mouse	T388	PHOSPHORYLATION	458333	ATKIAIStPTSKPAA		molecular association, regulation	cell cycle regulation	PLK1(INDUCES)		7383	1	0	1	phosphorylation plays important role in recruitment of Plk1 to kinetochores and progression of cell cycle	
ER-alpha	DNA binding protein; Nuclear receptor	P03372	2099	ESR1	6q25.1	human	K302	UBIQUITINATION	2134725	PLMIKRSkKNSLALS		activity, inhibited	transcription, altered			11006907	2	0	0	K302/303A mutants are more active then wt protein at low concentration of E2 	
Kv1.2	Channel, potassium; Membrane protein, integral; Membrane protein, multi-pass	P16389	3737	KCNA2	1p13	human	Y415	PHOSPHORYLATION	455552	VIVSNFNyFYHRETE		molecular association, regulation		cortactin(DISRUPTS)		5437	1	0	1		
MCU	Membrane protein, integral; Membrane protein, multi-pass; Mitochondrial	Q3UMR5	215999	Mcu		mouse	S56	PHOSPHORYLATION	27259016	TAHQRPAsWQSVGAA			apoptosis, induced			27257011	1	0	0	increase CCDC109A current and myocardial cell death	
GRK2	EC 2.7.11.15; KINASE; Kinase, protein; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor)	P26817	25238	Adrbk1		rat	S29	PHOSPHORYLATION	447724	ATPAARAsKKILLPE		intracellular localization; enzymatic activity, induced				13354716	2	0	0		
CBX1	Transcription factor	P83917	12412	Cbx1		mouse	T51	PHOSPHORYLATION	2753801	GFSDEDNtWEPEENL	Chromo	molecular association, regulation; intracellular localization			DNA(DISRUPTS)	10353913	2	0	0		
ROMK	Channel, potassium; Membrane protein, integral; Membrane protein, multi-pass	P48048	3758	KCNJ1	11q24	human	S201	PHOSPHORYLATION	2813508	FSKNAVIsKRGGKLC	IRK	activity, induced; intracellular localization				8783	3	0	1		
ChREBP	Transcription factor	Q8VIP2	171078	Mlxipl		rat	S140	PHOSPHORYLATION	2103610	QYVQRRKsPVCGFVT		molecular association, regulation; intracellular localization	transcription, altered	14-3-3 beta(INDUCES); KPNA2(DISRUPTS)		3301223	3	1	0	inhibits nuclear localization of ChREBP under low glucose conditions	
Akt1	EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor)	P31749	207	AKT1	14q32.32	human	Y176	PHOSPHORYLATION	14515900	EKATGRYyAMKILKK	Pkinase	intracellular localization; enzymatic activity, induced	cell cycle regulation; transcription, altered			14146306	1	1	0	membrane localization	
OSR1	EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, STE; Protein kinase, Ser/Thr (non-receptor)	O95747	9943	OXSR1	3p22.2	human	S325	PHOSPHORYLATION	456504	VRRVPGSsGRLHKTE		enzymatic activity, induced				2195492	6	5	0		
HDAC8	EC 3.5.1.98; Hydrolase	Q9BY41	55869	HDAC8	Xq13	human	S39	PHOSPHORYLATION	450667	AKIPKRAsMVHSLIE	Hist_deacetyl	enzymatic activity, inhibited; protein conformation				8545; 3062	1	0	2	Crystalographic data suggests how phosphorylation of S39 alters conformation and negatively regulate HDAC8 activity.	
Kv3.4	Channel, potassium; Membrane protein, integral; Membrane protein, multi-pass	Q03721	3749	KCNC4	1p21	human	S8	PHOSPHORYLATION	451075	MISSVCVsSYRGRKS	Potassium_chann	receptor inactivation, altered				3296	1	0	0		
catalase	Amino Acid Metabolism - tryptophan; Apoptosis; EC 1.11.1.6; Endoplasmic reticulum; Energy Metabolism - methane; Hydrolase; Mitochondrial; Oxidoreductase	P24270	12359	Cat		mouse	Y231	PHOSPHORYLATION	450444	NADGEAVyCKFHYKT	Catalase	protein degradation; enzymatic activity, induced				3035	2	6	315		
doublecortin	Cytoskeletal protein; Motility/polarity/chemotaxis	O88809	13193	Dcx		mouse	S332	PHOSPHORYLATION	451363	STPKSKQsPISTPTS		intracellular localization	cell motility, altered; cell growth, altered	TUBB(DISRUPTS)		15278813	4	3	16		
ROMK	Channel, potassium; Membrane protein, integral; Membrane protein, multi-pass	P48048	3758	KCNJ1	11q24	human	S219	PHOSPHORYLATION	2461201	RVANLRKsLLIGSHI	IRK	activity, induced; protein conformation; activity, inhibited				3309521; 2807231; 2807222	5	0	0		
SNAP-25	Vesicle protein	P60880	6616	SNAP25	20p12-p11.2	human	S187	PHOSPHORYLATION	448668	RIMEKADsNKTRIDE	Exonuc_VII_L; SNARE	activity, induced; molecular association, regulation	exocytosis, altered	SYT1(DISRUPTS); STX1A(INDUCES)		9596; 1968317	12	0	0	increases calcium-dependent exocytosis; enhances exocytosis by DAG	
Cx50	Channel, misc.; Membrane protein, integral; Membrane protein, multi-pass	P36381	395846	GJA8		chicken	S395	PHOSPHORYLATION	9824606	KASSRARsDDLTV__		activity, induced				18668241	1	2	0	enhances Cx50 gap junction coupling	
VAV1	Guanine nucleotide exchange factor, Rac/Rho; Motility/polarity/chemotaxis	P15498	7409	VAV1	19p13.2	human	Y160	PHOSPHORYLATION	447865	VEEDEDLyDCVENEE		molecular association, regulation; activity, inhibited	cytoskeletal reorganization; cell adhesion, altered	ITGB3(INDUCES); PLCG1(INDUCES); Lck(INDUCES); PIK3R1(INDUCES)		5188; 2587209	5	0	0	regulates Cdc42 activation. 	
ANXA1	Calcium-binding protein; Lipid binding protein	P04083	301	ANXA1	9q21.13	human	S27	PHOSPHORYLATION	447972	EYVQTVKsSKGGPGS		intracellular localization	exocytosis, altered; cytoskeletal reorganization			6317; 9689603	4	0	0	after CRH stimulation; S27A or S45A mutations prevented translocation of ANXA1 to the plasma membrane and stimulated ACTH release; S26A is similar to the WT distribution (granular structures in cytoplasm + localization with phagosomes).  S26E no longer associates with the phagosomes though.  	
TRAF4	Adaptor/scaffold; DNA binding protein	Q9BUZ4	9618	TRAF4	17q11-q12	human	S426	PHOSPHORYLATION	3211032	KPGTWRGsLDESSLG	MATH	protein stabilization	signaling pathway regulation			25233213	1	16	9	negative regulator of an innate immune signaling pathway	
TNIK	EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, STE; Protein kinase, Ser/Thr (non-receptor)	Q9UKE5	23043	TNIK	3q26.31	human	S764	PHOSPHORYLATION	451976	RTRVRANsKSEGSPV		intracellular localization				14784605	1	13	23		
GRK2	EC 2.7.11.15; KINASE; Kinase, protein; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor)	P21146	282682	ADRBK1		cow	S670	PHOSPHORYLATION	447725	KMKNKPRsPVVELSK		activity, inhibited				1107	3	16	17		
TIRAP	Adaptor/scaffold	P58753	114609	TIRAP	11q24.2	human	Y187	PHOSPHORYLATION	463810	SGLSRAAyPPELRFM	TIR_2	activity, induced; molecular association, regulation; phosphorylation	transcription, altered	TLR4(DISRUPTS); MYD88(DISRUPTS); Btk(INDUCES)		7871; 1713124	2	0	0		
FOXO1A	DNA binding protein; Nuclear receptor co-regulator; Transcription factor	Q12778	2308	FOXO1	13q14.1	human	S416	PHOSPHORYLATION	478368	PPNTSLNsPSPNYQK		intracellular localization	transcription, altered			12525214	4	0	0	multiple site mutant (8A)	
AQP0	Channel, misc.; Membrane protein, integral; Membrane protein, multi-pass	P51180	17339	Mip		mouse	S235	PHOSPHORYLATION	450116	KSVSERLsILKGARP		molecular association, regulation		calmodulin(DISRUPTS)		22498402	4	8	0		
desmoplakin 3	Cytoskeletal protein; Motility/polarity/chemotaxis	P14923	3728	JUP	17q21	human	Y133	PHOSPHORYLATION	456971	AIVHLINyQDDAELA	HEAT_2; RIX1	molecular association, regulation	transcription, induced	desmoplakin(INDUCES); TCF4(DISRUPTS); CTNNA1(DISRUPTS)		5375	1	0	1		
IRS1	Adaptor/scaffold; Motility/polarity/chemotaxis	P35569	16367	Irs1		mouse	S408	PHOSPHORYLATION	454417	CLFPRRSsASVSGSP		activity, inhibited				4285	2	0	0		
polycystin 2	Channel, cation; Membrane protein, integral; Membrane protein, multi-pass	Q13563	5311	PKD2	4q22.1	human	S801	PHOSPHORYLATION	15702202	SSLPRPMsSRSFPRS		activity, induced	cell cycle regulation			15562501	2	0	0	regulates ATP-induced calcium release	
IKKB	EC 2.7.11.10; KINASE; Kinase, protein; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor)	O14920	3551	IKBKB	8p11.2	human	S740	PHOSPHORYLATION	5014909	SFTALDWsWLQTEEE	IKKbetaNEMObind	molecular association, regulation		IKK-gamma(DISRUPTS)		5007912	1	0	0		
HDAC2	DEACETYLASE; Deacetylase; EC 3.5.1.98; Nuclear receptor co-regulator; Transcription, coactivator/corepressor	Q92769	3066	HDAC2	6q21	human	S422	PHOSPHORYLATION	467979	IACDEEFsDSEDEGE		molecular association, regulation; acetylation; enzymatic activity, inhibited		p53(INDUCES); HDAC1(INDUCES)		13354700	2	37	35		
ATF-2	C2H2-type zinc finger protein; Transcription factor	P15336	1386	ATF2	2q32	human	S121	PHOSPHORYLATION	6406001	LATPIIRsKIEEPSV		intracellular localization	transcription, induced			6331321	1	0	0	plays a role in the regulation of both TPA- and c-Jun-dependent transcription	
Src	EC 2.7.10.2; KINASE; Kinase, protein; Protein kinase, TK; Protein kinase, tyrosine (non-receptor)	P12931	6714	SRC	20q12-q13	human	Y530	PHOSPHORYLATION	448235	FTSTEPQyQPGENL_		molecular association, regulation; enzymatic activity, inhibited; protein processing; protein conformation		Src(INDUCES)		6566; 4313605; 2757; 15331016; 2978; 2519601; 4664	104	13	966		
hnRNP E1	RNA binding protein; RNA splicing; Translation	P60335	23983	Pcbp1		mouse	S43	PHOSPHORYLATION	13258708	VKRIREEsGARINIS	KH_1		translation, altered	eEF1A1(DISRUPTS)		12778812; 19075408	1	0	0		
NIPA	Cell cycle regulation; Ubiquitin conjugating system	Q80YV2	232679	Zc3hc1		mouse	S358	PHOSPHORYLATION	483339	TRSWESSsPVDRPEL		molecular association, regulation	cell cycle regulation	CUL1(DISRUPTS)		26341728	2	11	11	ERK2 phosphorylation at G2/M is sufficient dissociation of SCF core complex at G2/M.	
APPL	Adaptor/scaffold; Nuclear receptor co-regulator	Q9UKG1	26060	APPL1	3p21.1-p14.3	human	S410	PHOSPHORYLATION	25802100	SFQQRHEsLRPAAGQ		molecular association, regulation; receptor recycling, altered	endocytosis, inhibited	OCRL(DISRUPTS)		25785414	1	0	0		
snRNP 70	RNA binding protein; RNA splicing; Spliceosome	P08621	6625	SNRNP70	19q13.3	human	S140	PHOSPHORYLATION	2103618	HMVYSKRsGKPRGYA	RRM_1	molecular association, regulation	cell growth, altered	HLA-DQB1(INDUCES)		8878	1	0	0	Phosphorylated peptide S140-P induced CD4+ Tcell proliferation and IL-2 secretion in MLR/lpr mice. 	
CNGA1	Channel, cation; Membrane protein, integral; Membrane protein, multi-pass	Q00194	281700	CNGA1		cow	Y498	PHOSPHORYLATION	450319	LKLQPQVySPGDYIC	cNMP_binding	protein conformation				4050	3	0	0	Phosphorylation promotes channel opening.	
PKCI	Cell adhesion; Cell development/differentiation; EC 2.7.11.13; EC 3.-.-.-; KINASE; Kinase, protein; Motility/polarity/chemotaxis; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor)	F1M7Y5	84006	Prkci		rat	Y334	PHOSPHORYLATION	450074	RLFFVIEyVNGGDLM	Pkinase	activity, induced				1240	1	0	0		
PELI1	Adaptor/scaffold; EC 6.3.2.-; EC 6.3.2.19; Ligase; UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase	Q96FA3	57162	PELI1	2p13.3	human	S78	PHOSPHORYLATION	7388013	NKDQHSIsYTLSRAQ	Pellino	ubiquitination; enzymatic activity, induced				7228504	2	0	0		
CUTL1	DNA binding protein; Membrane protein, integral; Transcription factor	P39880	1523	CUX1	7q22.1	human	S1215	PHOSPHORYLATION	460700	AYMKRRHsSVSDSQP		molecular association, regulation	cell motility, altered; transcription, inhibited		DNA(DISRUPTS)	7781	1	1	6		
TRAF1	Adaptor/scaffold; Apoptosis	P39428	22029	Traf1		mouse	S139	PHOSPHORYLATION	26331402	MALERNLsELQLQAA		molecular association, regulation	signaling pathway regulation	TNF-R2(INDUCES); TBK1(DISRUPTS)		27579002; 25785419	2	0	0	regulation association of TBK1 with TNFRSF9 and  NFkB activation; TNF-R2 regulation of IKK and JNK pathways	
MBD4	Apoptosis; DNA repair; Deoxyribonuclease; EC 3.2.2.-	O95243	8930	MBD4	3q21.3	human	S165	PHOSPHORYLATION	22730001	CSMAALTsHLQNQSN		enzymatic activity, induced	DNA repair, induced			22723936	1	0	0		
DTNB	Calcium-binding protein; Motility/polarity/chemotaxis	O60941	1838	DTNB	2p24	human	T11	PHOSPHORYLATION	27100600	ESGNKRKtMAEKRQL		molecular association, regulation		KIF1A(INDUCES)		26349408	1	1	0		
C/EBP-beta	DNA binding protein; Motility/polarity/chemotaxis; Transcription factor	P21272	24253	Cebpb		rat	T189	PHOSPHORYLATION	447878	SSSSPPGtPSPADAK			transcription, altered; cell growth, altered		DNA(INDUCES)	8352; 8351	28	5	0		
STAT5B	DNA binding protein; Transcription factor	P52632	25126	Stat5b		rat	Y699	PHOSPHORYLATION	448198	TAKAADGyVKPQIKQ		molecular association, regulation; intracellular localization			DNA(INDUCES)	2065	30	22	2207		
ACC1	Carbohydrate Metabolism - propanoate; Carbohydrate Metabolism - pyruvate; EC 6.3.4.14; EC 6.4.1.2; Ligase; Lipid Metabolism - fatty acid biosynthesis	Q13085	31	ACACA	17q21	human	S1263	PHOSPHORYLATION	463821	FSDSPPQsPTFPEAG	ACC_central	molecular association, regulation		BRCA1(INDUCES)		7843; 6271207	2	8	2	regulated through cell cycle	
HS1	Adaptor/scaffold; Motility/polarity/chemotaxis	P14317	3059	HCLS1	3q13	human	Y378	PHOSPHORYLATION	451635	EPEPENDyEDVEEMD		molecular association, regulation; intracellular localization	apoptosis, altered; cell motility, altered; cytoskeletal reorganization; transcription, altered	VAV1(INDUCES)		7894; 4010; 4313616	7	1	38		
NEDD1	Cell cycle regulation	Q8NHV4	121441	NEDD1	12q23.1	human	S377	PHOSPHORYLATION	12737836	EKAGLPRsINTDTLS		intracellular localization	cytoskeletal reorganization			25612405	1	2	0	recruitment of NEDD1 and gamma-tubulin to the centrosome during mitosis	
PKR	EC 2.7.10.2; EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor); Translation	P19525	5610	EIF2AK2	2p22-p21	human	Y162	PHOSPHORYLATION	458272	QLAAKLAyLQILSEE	dsrm	enzymatic activity, induced	translation, altered; cell growth, altered			7342	1	0	0		
FLI	Actin binding protein; Nuclear receptor co-regulator	Q13045	2314	FLII	17p11.2	human	T818	PHOSPHORYLATION	25787600	LHRPRHAtVSRSLEG	Gelsolin		transcription, induced			25785422	1	0	0	may induce transcription of the estrogen receptor	
RACK1	Adaptor/scaffold; G protein; G protein, heterotrimeric; G protein, heterotrimeric beta WD; Motility/polarity/chemotaxis; Nuclear receptor co-regulator	P63244	10399	GNB2L1	5q35.3	human	Y228	PHOSPHORYLATION	450543	LNEGKHLyTLDGGDI	WD40	molecular association, regulation		Src(NOT_REPORTED)		3664	3	2	3		
ANPA	EC 4.6.1.2; Guanylyl cyclase; KINASE; Kinase, protein; Lyase; Membrane protein, integral; Nucleotide Metabolism - purine; Protein kinase, RGC; Protein kinase, dual-specificity; Receptor, misc.	P16066	4881	NPR1	1q21-q22	human	S542	PHOSPHORYLATION	448229	GRGSNYGsLLTTEGQ	Pkinase_Tyr	activity, induced				896	2	2	3		
LC3A	Autophagy; Microtubule binding protein; Ubiquitin-like modifier; Vesicle protein	Q91VR7	66734	Map1lc3a		mouse	S12	PHOSPHORYLATION	15116600	RPFKQRRsFADRCKE		intracellular localization	autophagy, altered			15022706	1	1	0		
PLD1 iso2	EC 3.1.4.4; Lipid Metabolism - ether lipid; Lipid Metabolism - glycerophospholipid; Motility/polarity/chemotaxis; Phospholipase	P70496-2	25096	Pld1		rat	S2	PHOSPHORYLATION	448572	______MsLRSEARV		enzymatic activity, induced				1392; 1391	4	0	0		
JAK3	EC 2.7.10.2; KINASE; Kinase, protein; Protein kinase, TK; Protein kinase, tyrosine (non-receptor)	P52333	3718	JAK3	19p13.1	human	Y785	PHOSPHORYLATION	450358	NSLISSDyELLSDPT		molecular association, regulation		SH2-B-beta(INDUCES)		3673	3	8	65		
CXCR4	GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR	P61073	7852	CXCR4	2q21	human	S325	PHOSPHORYLATION	3849622	TSVSRGSsLKILSKG		activity, induced; protein degradation; molecular association, regulation; ubiquitination; intracellular localization		ITCH(INDUCES)		6066708	4	5	6	binding in vitro and in vivo	
ITGB1	Cell adhesion; Cell surface; Membrane protein, integral; Motility/polarity/chemotaxis; Receptor, misc.	P09055	16412	Itgb1		mouse	T788	PHOSPHORYLATION	448600	PIYKSAVtTVVNPKY	Integrin_b_cyt		cell adhesion, altered			1685; 10425104	9	1	1		
dCK	EC 2.7.1.74; Kinase, other; Nucleotide Metabolism - purine; Nucleotide Metabolism - pyrimidine	P27707	1633	DCK	4q13.3-q21.1	human	S15	PHOSPHORYLATION	460586	SCPSFSAsSEGTRIK		phosphorylation				14851000	4	9	4	regulates phosphorylation of S74	
ILT2	Membrane protein, integral; Receptor, misc.	Q8N423	10288	LILRB2	19q13.4	human	Y562	PHOSPHORYLATION	2091907	EAPQDVTyAQLHSLT	Protocadherin; Bravo_FIGEY	molecular association, regulation		CSK(INDUCES); SHP-1(INDUCES)		4315; 3538	2	0	1	Mutation of Y533 prevented binding in vivo. 	
TIF1A	Transcription initiation complex	Q9NYV6	54700	RRN3	16p12	human	S635	PHOSPHORYLATION	11315000	DTHFRSPsSSVGSPP		activity, inhibited	transcription, altered	TAF1C(DISRUPTS)		11189906	1	0	0	inhibits transcription complex formation	
MYPT1	Motility/polarity/chemotaxis; Protein phosphatase, regulatory subunit	Q90623	396020	PPP1R12A		chicken	T695	PHOSPHORYLATION	448587	ARQSRRStQGVTLTD		enzymatic activity, inhibited				8662	49	15	213		
Ctip	EC 3.1.-.-; Transcription, coactivator/corepressor	Q99708	5932	RBBP8	18q11.2	human	S745	PHOSPHORYLATION	448392	SCLADSFsQAADEEE		molecular association, regulation		BRCA1(DISRUPTS)		1047	1	0	1		
Cot	EC 2.7.11.25; KINASE; Kinase, protein; Protein kinase, STE; Protein kinase, Ser/Thr (non-receptor)	P41279	1326	MAP3K8	10p11.23	human	S62	PHOSPHORYLATION	2868603	QNDERSKsLLLSGQE		enzymatic activity, induced				2865420	1	1	0		
OLIG2	Transcription factor	Q9EQW6	50913	Olig2		mouse	S13	PHOSPHORYLATION	18357900	SLVSSRPsSPEPDDL			cell cycle regulation; cell differentiation, altered; carcinogenesis, altered			18357300	1	1	0	maintains proliferation and suppresses differentiation of neural progenitors	
ZNF420	C2H2-type zinc finger protein; Transcription factor	Q8TAQ5	147923	ZNF420	19q13.12	human	S68	PHOSPHORYLATION	7669300	NTYETELsQWEMSDR		molecular association, regulation		p53(DISRUPTS)		7647800	1	0	0	in response to DNA damage, ZNF420 (Apak) dissociates from p53 and activates p53-mediated apoptosis	
cortactin	Actin binding protein; Cytoskeletal protein; Motility/polarity/chemotaxis	Q60598	13043	Cttn		mouse	S407	PHOSPHORYLATION	467687	QTPPASPsPQPIEDR			cell cycle regulation; cell motility, altered			2790302	0	15	19		
Src	EC 2.7.10.2; KINASE; Kinase, protein; Protein kinase, TK; Protein kinase, tyrosine (non-receptor)	P12931	6714	SRC	20q12-q13	human	S12	PHOSPHORYLATION	448230	KSKPKDAsQRRRSLE		molecular association, regulation; enzymatic activity, induced		PPP2R2C(INDUCES)		1713122	5	0	0	 interferes with PPP2R2C abitity to inhibit JNK phosphorylation following exposure to UV; in cells treated with UV	
WT1	C2H2-type zinc finger protein; DNA binding protein; Transcription factor	P19544	7490	WT1	11p13	human	S365	PHOSPHORYLATION	451117	KDCERRFsRSDQLKR	Ofd1_CTDD; zf-H2C2_2		transcription, altered			3323	1	0	0	Phosphorylation of S365 inhibited WT1 DNA-binding, and thereby decreased WT1 transcriptional repression activity.	
HER2	EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Protein kinase, TK; Protein kinase, tyrosine (receptor)	P04626	2064	ERBB2	17q12	human	Y877	PHOSPHORYLATION	448694	LDIDETEyHADGGKV	Pkinase_Tyr		cell growth, altered			11999207	17	8	90	residues around Y877 promote binding to Src, but independent of phosphorylation	
calsequestrin 2	Calcium-binding protein	P12637	483134	CASQ2		dog	S405	PHOSPHORYLATION	451476	DEESNDDsDDDDE__		intracellular localization				18759800	3	2	0	regulates intracellular trafficking of calsequestrin 2	
ER-alpha	DNA binding protein; Nuclear receptor	P03372	2099	ESR1	6q25.1	human	S294	PHOSPHORYLATION	451560	RAANLWPsPLMIKRS		activity, induced	transcription, altered			12021304	7	1	0		
HSPB8		Q9UJY1	26353	HSPB8	12q24.23	human	S57	PHOSPHORYLATION	2201401	DWALPRLsSAWPGTL		protein degradation; protein conformation				2195726	1	2	0	in vitro;  decreases oligomerization and chaperone-like activity of H11	
DCC	Immunoglobulin superfamily; Membrane protein, integral; Receptor, misc.	P43146	1630	DCC	18q21.3	human	Y1363	PHOSPHORYLATION	1979800	AIEPKVPyTPLLSQP	Neogenin_C	molecular association, regulation		Lck(INDUCES); Fyn(INDUCES)		1968361	1	0	0		
FAK	EC 2.7.1.112; EC 2.7.10.2; KINASE; Kinase, protein; Protein kinase, TK; Protein kinase, tyrosine (non-receptor)	Q05397	5747	PTK2	8q24.3	human	Y397	PHOSPHORYLATION	447887	SVSETDDyAEIIDEE		protein degradation; molecular association, regulation; intracellular localization; phosphorylation; enzymatic activity, induced	carcinogenesis, induced; apoptosis, altered; endocytosis, altered; transcription, altered; cell differentiation, altered; cell motility, altered; apoptosis, inhibited; cytoskeletal reorganization; cell adhesion, altered; cell growth, altered	RASA1(INDUCES); PIK3R2(DISRUPTS); Src(DISRUPTS); FAK(INDUCES); PIK3R1(INDUCES)		5843; 6011116; 5617; 4445; 4904506; 7889906; 5912; 4904508; 6503; 18021000; 2865401; 2590901; 14148616; 4904500; 7324126; 7036; 3433201; 9389; 5618; 4894710; 14148618; 834; 7167; 5930; 13789003	234	21	470		
C5aR	GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR	P21730	728	C5AR1	19q13.3-q13.4	human	S338	PHOSPHORYLATION	448820	ESKSFTRsTVDTMAQ		molecular association, regulation; receptor desensitization, altered		ARRB1(INDUCES); ARRB2(INDUCES)		1995; 9155; 1994	4	0	1	induces translocation of beta-arrestin into the plasma membrane	
EGFR	EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Protein kinase, TK; Protein kinase, tyrosine (receptor)	P00533	1956	EGFR	7p12	human	S1071	PHOSPHORYLATION	448052	SFLQRYSsDPTGALT		receptor desensitization, altered; receptor internalization, altered				1060; 3881	9	1	7		
EGFR	EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Protein kinase, TK; Protein kinase, tyrosine (receptor)	P00533	1956	EGFR	7p12	human	Y869	PHOSPHORYLATION	448061	LGAEEKEyHAEGGKV	Pkinase_Tyr	activity, induced; molecular association, regulation; enzymatic activity, induced	cell cycle regulation; cell motility, altered; apoptosis, inhibited; cell adhesion, altered; cell growth, altered	PKCZ(INDUCES); PKCE(INDUCES); COX2(INDUCES)		7550843; 2452303; 5183; 6783; 6086; 14058625; 5489; 2452302; 762704; 5886	62	10	128		
AT1	GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR	P25095	24180	Agtr1		rat	S338	PHOSPHORYLATION	452092	STKMSTLsYRPSDNM		activity, induced				8139	4	0	0		
OAZ2	Inhibitor protein	O08608	18247	Oaz2		mouse	S186	PHOSPHORYLATION	11507801	YPLDQNLsDED____		molecular association, regulation		ODC(INDUCES)		11424212	1	0	0		
Notch 1	Membrane protein, integral; Motility/polarity/chemotaxis; Receptor, misc.; Transcription factor	Q01705	18128	Notch1		mouse	K2050	ACETYLATION	18899506	NKDMQNNkEETPLFL	Ank_2	protein stabilization; ubiquitination				18899000	1	1	0		
CKM	Amino Acid Metabolism - arginine and proline; EC 2.7.3.2; KINASE; Kinase, other	P00564	24265	Ckm		rat	S128	PHOSPHORYLATION	5410301	LDPNYVLsSRVRTGR	ATP-gua_Ptrans	activity, inhibited				5358619	1	2	0		
CD19	Cell surface; Membrane protein, integral	P15391	930	CD19	16p11.2	human	Y531	PHOSPHORYLATION	447639	HEEDADSyENMDNPD		molecular association, regulation		Lyn(INDUCES); VAV1(INDUCES); PIK3CA(INDUCES)		845	6	2	18		
PLCG1	Carbohydrate Metabolism - inositol phosphate; EC 3.1.4.11; Motility/polarity/chemotaxis; Phospholipase	P08487	281987	PLCG1		cow	Y509	PHOSPHORYLATION	464036	NHEWYPHyFVLTSSK	PH	enzymatic activity, induced	cell motility, altered; cytoskeletal reorganization; cell growth, altered	PLCG1(INDUCES)		9126	3	0	8	PLCG1 with a nonfunctional domain is constitutively active. ELISA assay showed SH2N and SH2C bound to Y132 phospho-peptide. Binding was mediated by SH2N domain. sPH blocks binding of SH2 domain to target proteins. Y509F /506F did not affect binding to pY132 LAT, but Y509A/F510A did show sigification binding. Y509A/F510A mutation showed increased NF-AT transcription, as compared to wild-type.   	
MC4R	GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR	P32245	4160	MC4R	18q22	human	S330	PHOSPHORYLATION	449103	GGLCDLSsRY_____		receptor internalization, altered				2136	2	0	0		
ER-alpha	DNA binding protein; Nuclear receptor	P03372	2099	ESR1	6q25.1	human	K302	ACETYLATION	459091	PLMIKRSkKNSLALS		activity, induced	transcription, altered			7602	2	0	0	suppresses ligand sensitivity	
SLC3A2	Membrane protein, integral; Transporter	P08195	6520	SLC3A2	11q13	human	S527	PHOSPHORYLATION	6003505	LSLFRRLsDQRSKER	DUF3459		cell adhesion, altered			5930022	1	0	0	enhances cell- cell interactions	
Smad2	DNA binding protein; Transcription factor	Q15796	4087	SMAD2	18q21.1	human	S240	PHOSPHORYLATION	450145	SDQQLNQsMDTGSPA		molecular association, regulation; intracellular localization		Smad3(INDUCES)		2766; 8817	2	0	0	S240-p translocates to the nucleus. 	
PGC-1 alpha	Nuclear receptor co-regulator; Transcription, coactivator/corepressor	O70343	19017	Ppargc1a		mouse	S241	PHOSPHORYLATION	13861602	KCASKKKsHTQPQSQ		intracellular localization	transcription, induced			13354730	2	0	0		
PRAS40	Apoptosis	Q96B36	84335	AKT1S1	19q13.33	human	T246	PHOSPHORYLATION	470067	LPRPRLNtSDFQKLK		molecular association, regulation; activity, inhibited; phosphorylation		14-3-3 beta(INDUCES); 14-3-3 eta(INDUCES); 14-3-3 beta(DISRUPTS)		2425213; 9309; 4214806; 8977; 2708105	24	31	739	S6K T412 phosphorylation; WT Akt1S1 does not biind to 14-3-3, after phorbol ester treatment but does after insulin treatment. T246S mutation does after treatment, and is inhibited by PD098059.	
p63	DNA binding protein; Transcription factor	Q9H3D4	8626	TP63	3q28	human	Y171	PHOSPHORYLATION	10359107	AIPSNTDyPGPHSFD	P53	protein stabilization				10353933	1	0	0		
14-3-3 sigma	Adaptor/scaffold	O70456	55948	Sfn		mouse	S186	PHOSPHORYLATION	456054	FHYEIANsPEEAISL	14-3-3; TPR_12	molecular association, regulation		Abl(DISRUPTS)		6829234	4	0	0		
Cas-L	Adaptor/scaffold; Motility/polarity/chemotaxis	Q14511	4739	NEDD9	6p25-p24	human	S369	PHOSPHORYLATION	9471800	VDGINRLsFSSTGST		protein degradation				9201019	1	0	0		
MKK6	EC 2.7.12.2; KINASE; Kinase, protein; Protein kinase, STE; Protein kinase, dual-specificity	P52564	5608	MAP2K6	17q24.3	human	Y219	PHOSPHORYLATION	1186001	IDAGCKPyMAPERIN	Pkinase	molecular association, regulation		RAC1(INDUCES)		1172808	1	0	0	enhances Rac-GTPase activity and inhibits NADPH oxidase activity in vivo	
ACE	EC 3.2.1.-; EC 3.4.15.1; Membrane protein, integral; Protease	P12821	1636	ACE	17q23.3	human	S1299	PHOSPHORYLATION	450699	SHGPQFGsEVELRHS		protein degradation; molecular association, regulation; intracellular localization	exocytosis, altered	ACE(INDUCES); MYH9(INDUCES)		3056; 7651; 12482261; 6834	7	12	15	increases protein dimerization; S1299 phosphorylation retains ACE in the plasma membrane and inhibits ACE secretion. 	
NFAT1	DNA binding protein; Transcription factor	Q60591	18019	Nfatc2		mouse	S176	PHOSPHORYLATION	447842	LSPASSGsSASFISD			transcription, inhibited			1188	0	1	0		
MEK1	EC 2.7.12.2; KINASE; Kinase, protein; Protein kinase, STE; Protein kinase, dual-specificity	Q01986	170851	Map2k1		rat	S222	PHOSPHORYLATION	448513	LIDSMANsFVGTRSY	Pkinase	enzymatic activity, induced				710; 1810	85	9	183		
occludin	Cell adhesion; Membrane protein, integral; Membrane protein, multi-pass; Motility/polarity/chemotaxis	Q16625	100506658	OCLN	5q13.1	human	S490	PHOSPHORYLATION	6094300	RLKQVKGsADYKSKK	DUF342; APG6; TBPIP; DUF4151; Occludin_ELL; GrpE; UPF0184; DUF4200; Laminin_II; TMF_TATA_bd	protein degradation; molecular association, regulation; ubiquitination; intracellular localization	endocytosis, altered	ZO1(DISRUPTS); Hrs(INDUCES); ITCH(INDUCES); epsin 1(INDUCES); EPS15(INDUCES)		6037504; 9158101	4	1	0	alters tight junctions and promotes vascular permeability ; alters the surface charge distribution	
SHP-1	EC 3.1.3.48; Motility/polarity/chemotaxis; PHOSPHATASE; Protein phosphatase, tyrosine (non-receptor)	P29351	15170	Ptpn6		mouse	Y208	PHOSPHORYLATION	3712666	EASGAFVyLRQPYYA		protein processing				4338210	1	0	0	promotes N terminal cleavage to 45 kDa form	
NFAT3	DNA binding protein; Transcription factor	Q14934	4776	NFATC4	14q11.2	human	S213	PHOSPHORYLATION	953804	ASRFGLGsPLPSPRA			transcription, induced			762729	1	3	1		
MEK1	EC 2.7.12.2; KINASE; Kinase, protein; Protein kinase, STE; Protein kinase, dual-specificity	Q01986	170851	Map2k1		rat	T286	PHOSPHORYLATION	448286	VEGDAAEtPPRPRTP	Pkinase	enzymatic activity, inhibited				1816	6	3	16		
PKD1	Autophagy; EC 2.7.11.13; KINASE; Kinase, protein; Motility/polarity/chemotaxis; Protein kinase, CAMK; Protein kinase, Ser/Thr (non-receptor)	Q9WTQ1	85421	Prkd1		rat	S916	PHOSPHORYLATION	447632	KALSERVsIL_____		molecular association, regulation; intracellular localization	transcription, altered	Kidins220(DISRUPTS)		2476703; 4313614	33	6	0	 Pasteurella multocida toxin induced nuclear localization and CREB transactivation	
FOXO3A	Autophagy; DNA binding protein; Transcription factor	Q9WVH4	56484	Foxo3		mouse	S314	PHOSPHORYLATION	449109	DFRSRTNsNASTVSG		intracellular localization				12482251	4	0	1	nuclear export in FOXO6/FOXO3A chimera	
Met	EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Protein kinase, TK; Protein kinase, tyrosine (receptor)	P16056	17295	Met		mouse	Y1363	PHOSPHORYLATION	448474	NVKCVAPyPSLLPSQ		molecular association, regulation	cell motility, altered; cytoskeletal reorganization	Shc1(INDUCES); PIK3C2A(INDUCES); Gab1(INDUCES); Grb2(INDUCES)		2849; 2850	7	4	90		
Grb2	Adaptor/scaffold; Cell development/differentiation; Motility/polarity/chemotaxis	P62993	2885	GRB2	17q24-q25	human	Y7	PHOSPHORYLATION	478849	_MEAIAKyDFKATAD	SH3_1		cell growth, altered			7324303	1	0	2	regulates cell proliferation	
NPM1	RNA binding protein; Translation	P06748	4869	NPM1	5q35.1	human	S4	PHOSPHORYLATION	452023	____MEDsMDMDMSP			cell cycle regulation; cytoskeletal reorganization			3937	3	11	1		
FOXC2	Apoptosis; Cell development/differentiation; DNA binding protein; Transcription factor	Q99958	2303	FOXC2	16q24.1	human	S232	PHOSPHORYLATION	3210579	ITKVETLsPESALQG		molecular association, regulation	transcription, altered		DNA(INDUCES)	28129300	1	10	0	implicated in vascular remodeling  in vivo	
ATP2A1	EC 3.6.3.8; Endoplasmic reticulum; Hydrolase; Membrane protein, integral; Membrane protein, multi-pass; Transporter	O14983	487	ATP2A1	16p12.1	human	S186	PHOSPHORYLATION	4764562	ILTGESVsVIKHTEP	E1-E2_ATPase	molecular association, regulation; enzymatic activity, induced		ATP2A1(INDUCES)		9689415	1	2	0		
Ret	EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Protein kinase, TK; Protein kinase, tyrosine (receptor)	P07949	5979	RET	10q11.2	human	Y809	PHOSPHORYLATION	450701	LIVEYAKyGSLRGFL	Pkinase_Tyr	enzymatic activity, induced	cell growth, altered			3073	1	0	0		
Lmr1	EC 2.7.11.1; KINASE; Kinase, protein; Membrane protein, integral; Protein kinase, TK; Protein kinase, tyrosine (receptor)	Q80YE4	11302	Aatk		mouse	S614	PHOSPHORYLATION	456515	PCPSRSPsPGTPMLP			apoptosis, induced			6694	1	0	0		
villin	Actin binding protein; Motility/polarity/chemotaxis	P09327	7429	VIL1	2q35	human	Y81	PHOSPHORYLATION	454006	EQGAAAIyTTQMDDF	Gelsolin	molecular association, regulation; intracellular localization	cytoskeletal reorganization	ACTB(INDUCES)		4155; 8883	3	0	0		
CD4	Cell surface; Membrane protein, integral	P01730	920	CD4	12p13.31	human	S433	PHOSPHORYLATION	451188	RRQAERMsQIKRLLS	Herpes_gE; Tcell_CD4_Cterm	protein degradation; intracellular localization; receptor internalization, altered				3363; 8363	3	0	1		
TBX21	DNA binding protein; Transcription factor	Q9JKD8	57765	Tbx21		mouse	K313	UBIQUITINATION	27930806	NAEITQLkIDNNPFA	T-box	protein stabilization; molecular association, regulation; phosphorylation		NFAT1(INDUCES)		27902358	1	0	0	crucial for T302 phosphorylation 	
MED1	Nuclear receptor co-regulator; Transcription, coactivator/corepressor	Q15648	5469	MED1	17q12	human	T1457	PHOSPHORYLATION	449866	HSKSPAYtPQNLDSE		activity, induced; protein stabilization; intracellular localization				7393	4	1	0		
Fos	DNA binding protein; Motility/polarity/chemotaxis; Transcription factor	P01100	2353	FOS	14q24.3	human	Y30	PHOSPHORYLATION	473044	AGDSLSYyHSPADSF		intracellular localization				9161	2	0	0	critical for association of Fos with endoplasmic reticulum membranes and phospholipid synthesis activation	
Crk	Adaptor/scaffold; Motility/polarity/chemotaxis	Q64010	12928	Crk		mouse	Y221	PHOSPHORYLATION	447951	GGPEPGPyAQPSVNT		molecular association, regulation		Crk(INDUCES); Abl iso2(INDUCES)		6232; 7309800	19	9	1142		
HER2	EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Protein kinase, TK; Protein kinase, tyrosine (receptor)	P06494	24337	Erbb2		rat	Y1224	PHOSPHORYLATION	448675	PAFDNLYyWDQNSSE		molecular association, regulation	apoptosis, altered	Shc1(INDUCES); Shc1(DISRUPTS)		1076; 12558700	21	1	7	inhibits apoptosis; This site can mediate transforming signals. 	
TACE	EC 3.4.24.86; Membrane protein, integral; Motility/polarity/chemotaxis; Protease	Q9Z1K9	57027	Adam17		rat	T735	PHOSPHORYLATION	449804	KPFPAPQtPGRLQAL		enzymatic activity, induced	signaling pathway regulation			18711401	11	4	2	;  required for NGF-induced p75NTR cleavage; important for cell survival	
MEF2D	DNA binding protein; Transcription factor	Q63943	17261	Mef2d		mouse	S190	PHOSPHORYLATION	2246701	QPALQRNsVSPGLPQ		protein stabilization; molecular association, regulation; protein conformation; activity, inhibited	cell differentiation, altered; transcription, inhibited	HDAC4(INDUCES)		2195477	2	1	0	inhibits myogenesis	
TSPYL2	DNA replication; Transcription regulation	Q9H2G4	64061	TSPYL2	Xp11.2	human	T340	PHOSPHORYLATION	12559513	GRLVSHStPIRWHRG	NAP		cell growth, altered			12482268	1	0	0		
MeCP2	Transcription, coactivator/corepressor	Q9Z2D6	17257	Mecp2		mouse	S80	PHOSPHORYLATION	452713	AVPEASAsPKQRRSI			apoptosis, altered; transcription, altered			11189909; 6804207	4	39	1		
p21Cip1	Cell cycle regulation; Inhibitor protein	P39689	12575	Cdkn1a		mouse	Y76	PHOSPHORYLATION	26400605	SLGLPKVyLSPGSRS			carcinogenesis, induced; cell growth, induced			26341759	1	0	0		
cortactin	Actin binding protein; Cytoskeletal protein; Motility/polarity/chemotaxis	Q14247	2017	CTTN	11q13	human	Y421	PHOSPHORYLATION	447702	RLPSSPVyEDAASFK		molecular association, regulation	cytoskeletal reorganization			3902; 1039	26	45	713	Tyrosine phosphorylation  is necessary for enhanced S1P barrier enhancement.   ; Previous work by the authors showed that src attenuates the actin cross-linking activity of cortactin.  These studies show that transfection with a cortactin mutant (F421/F470/F486) impairs the motility of endothelial cells.	
CCDC6	Apoptosis; Cytoskeletal protein	Q16204	8030	CCDC6	10q21	human	S413	PHOSPHORYLATION	4957370	SHGITRPsPRRSNSP		protein degradation; molecular association, regulation		FBXW7(INDUCES)		27132403	1	2	2		
PLD2	EC 3.1.4.4; Lipid Metabolism - ether lipid; Lipid Metabolism - glycerophospholipid; Motility/polarity/chemotaxis; Phospholipase	O14939	5338	PLD2	17p13.1	human	Y511	PHOSPHORYLATION	10036100	FFWLGKDySNLITKD		molecular association, regulation; enzymatic activity, induced	cell growth, altered	CD45(DISRUPTS); Grb2(INDUCES)		12778820; 9985922	2	1	0	dephosphorylated Y179 and Y511 mediates an induction of cell proliferation	
PKCA	EC 2.7.11.13; KINASE; Kinase, protein; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor)	NP_035231	18750	Prkca		mouse	Y658	PHOSPHORYLATION	455927	SDFEGFSyVNPQFVH	Pkinase_C	molecular association, regulation		Grb2(INDUCES)		5666	4	0	0		
RRas	G protein; G protein, monomeric, Ras; Motility/polarity/chemotaxis	P10301	6237	RRAS	19q13.3-qter	human	Y66	PHOSPHORYLATION	448122	DPTIEDSyTKICSVD	Ras	molecular association, regulation	cell motility, altered; cytoskeletal reorganization; cell adhesion, altered			1969109; 1629; 2675	3	0	0	Y66E blocks activated (38V) R-Ras-induced cell retraction (cells with spikes).  Y66F blocks activated R-Ras inhibition of cell migration during ephrin-B1 stimulation (effect present but not as intense in Y66F non-activated R-ras allele). Y66F inhibits ephrin-A1-induced growth cone collapse.	
myocardin	Cell development/differentiation; Transcription factor	Q8VIM5	214384	Myocd		mouse	S466	PHOSPHORYLATION	3627506	PPISPASsDLSAAGS			transcription, inhibited			6856	1	0	0		
NDEL1	Microtubule binding protein; Protease	Q9ERR1	83431	Ndel1		mouse	S251	PHOSPHORYLATION	474509	LTPSARIsALNIVGD	NUDE_C	intracellular localization				9262	1	1	0	important for centrosome separation during mitosis	
EpoR	EC 2.7.10.2; Membrane protein, integral; Receptor, cytokine	P19235	2057	EPOR	19p13.3-p13.2	human	Y368	PHOSPHORYLATION	449883	SEHAQDTyLVLDKWL		molecular association, regulation; phosphorylation	cell cycle regulation; apoptosis, inhibited; transcription, altered; cell growth, altered	STAT5A(INDUCES); SOCS3(INDUCES)		8833; 5412; 6399; 7303917; 8493; 2728; 2427	16	0	0	activates Stat5	
DDX58	EC 3.6.1.-; EC 3.6.4.13; Hydrolase	O95786	23586	DDX58	9p12	human	S8	PHOSPHORYLATION	12613701	MTTEQRRsLQAFQDY		molecular association, regulation; ubiquitination; intracellular localization		TRIM25(DISRUPTS); MAVS(DISRUPTS)		27305548; 14058613	4	2	0	Phosphorylation inhibits antiviral signaling.	
PLK4	EC 2.7.11.21; KINASE; Kinase, protein; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor)	Q64702	20873	Plk4		mouse	T300	PHOSPHORYLATION	12654006	TITASSGtSLSGSLL		protein degradation; ubiquitination				12525201	1	1	0		
HIPK2	EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, CMGC; Protein kinase, Ser/Thr (non-receptor)	Q9H2X6	28996	HIPK2	7q32-q34	human	K32	SUMOYLATION	1727700	FCSVKKLkIEPSSNW		intracellular localization; phosphorylation; enzymatic activity, induced	transcription, inhibited			8962	3	0	0	K32A (aka K25A) mutant increases phosphorylation of CBX4	
NCAM-L1	Cell adhesion; Membrane protein, integral	P32004	3897	L1CAM	Xq28	human	S1248	PHOSPHORYLATION	472277	NDSSGATsPINPAVA			cytoskeletal reorganization; cell adhesion, inhibited			27619343; 9177	4	9	0	S1248 phosphorylation is necessary for ethanol inhibition of adhesion.	
ADCY2	Adenylyl cyclase; EC 4.6.1.1; Lyase; Membrane protein, integral; Membrane protein, multi-pass; Nucleotide Metabolism - purine	P26769	81636	Adcy2		rat	S543	PHOSPHORYLATION	25795202	NRTLRTKsQKKRFEE	DUF1053	activity, induced				25712658	1	1	0	cAMP release	
AML3	DNA binding protein; Transcription factor	Q08775	12393	Runx2		mouse	S326	PHOSPHORYLATION	460575	KLDDSKPsLFSDRLS		activity, induced	transcription, induced			7479	1	0	0		
IkB-beta	Inhibitor protein	Q15653	4793	NFKBIB	19q13.1	human	S23	PHOSPHORYLATION	447916	WCDSGLGsLGPDAAA		protein degradation				1125	5	0	0		
PXN	Adaptor/scaffold; Cell adhesion; Cytoskeletal protein; Motility/polarity/chemotaxis	Q8VI36	19303	Pxn		mouse	Y31	PHOSPHORYLATION	448785	FLSEEPPySYPTGNH		activity, induced; molecular association, regulation; phosphorylation	apoptosis, altered; cell adhesion, induced; cell motility, altered; cytoskeletal reorganization; cell adhesion, altered	RASA1(INDUCES); vinculin(INDUCES)		5011228; 22879418; 3681; 8887	35	6	64	regulates ERK phosphorylation; Paxillin Y31/118 phosphorylation promotes paxillin-vinculin interaction and vinculin recruitment to focal adhesions. ; Y31/118 phosphorylation induces RhoA activation. 	
MgcRacGAP	GTPase activating protein, Rac/Rho	Q9H0H5	29127	RACGAP1	12q13.12	human	S170	PHOSPHORYLATION	459865	ESLDWDSsLVKTFKL	CALCOCO1		cell cycle regulation			7543516	1	2	0		
CCR5	GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Motility/polarity/chemotaxis; Receptor, GPCR; Receptor, cytokine	P51681	1234	CCR5	3p21.31	human	S342	PHOSPHORYLATION	449902	ASSVYTRsTGEQEIS		molecular association, regulation; receptor desensitization, altered; receptor internalization, altered		ARRB1(INDUCES); ARRB2(INDUCES)		2453; 3438; 5346	3	0	0		
SF2	RNA binding protein; RNA splicing; Spliceosome	Q07955	6426	SRSF1	17q22	human	S119	PHOSPHORYLATION	27106000	YGPPSRRsENRVVVS		molecular association, regulation; activity, inhibited	RNA splicing, inhibited		RNA(INDUCES)	26350302	1	0	0		
TSC2	Cell cycle regulation; GTPase activating protein, misc.; Nuclear receptor co-regulator; Tumor suppressor	P49816	24855	Tsc2		rat	T1373	PHOSPHORYLATION	469994	SSEGARPtVDLSFQP		activity, inhibited; phosphorylation	translation, altered; apoptosis, inhibited			8973	2	2	25	inhibits mTOR signaling.  required for Wnt-3a to stimulation phosphorylation of S6K and 4EBP1 and increase protein levels of cyclin D1 and VEGF (cyclin D1 through translation not transcription).	
ATM	EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, ATYPICAL; Protein kinase, Ser/Thr (non-receptor)	Q62388	11920	Atm		mouse	S1987	PHOSPHORYLATION	448797	SPTFEEGsQGTTISS		intracellular localization	chromatin organization, altered			5930010; 2483404; 9265	128	11	4		
Borealin	Cell cycle regulation	Q53HL2	55143	CDCA8	1p34.3	human	T169	PHOSPHORYLATION	4203202	KRSSRANtVTPAVGR	Borealin		cell cycle regulation; cytoskeletal reorganization			4201803	2	0	0	chromosome alignment in mitosis	
Kv1.3	Channel, potassium; Membrane protein, integral; Membrane protein, multi-pass	P22001	3738	KCNA3	1p13.3	human	Y162	PHOSPHORYLATION	3820931	SFDAILYyYQSGGRI	K_tetra	activity, inhibited				6331318	1	0	0		
AML1	DNA binding protein; Transcription factor	Q01196	861	RUNX1	21q22.3	human	T273	PHOSPHORYLATION	454403	SPSVHPAtPISPGRA		molecular association, regulation; phosphorylation		CBFB(INDUCES)		4042514	6	1	5	promotes AML1 and p300 phosphorylation	
PrlR	Membrane protein, integral; Receptor, cytokine	Q08501	19116	Prlr		mouse	Y532	PHOSPHORYLATION	3188101	VPETSKEyAKVSGVT		molecular association, regulation	transcription, altered	CISH(INDUCES)		8756	1	0	0	binding of CISH inhibits STAT5 activation (STAT5 does not bind to this site though)	
SORBS1 iso5	Cell adhesion; Cytoskeletal protein; Motility/polarity/chemotaxis	Q62417-5	20411	Sorbs1		mouse	Y326	PHOSPHORYLATION	460519	RAEPKSIyEYQPGKS			cell motility, altered			11419365	1	5	243	mutation of this site inhibits cell spreading 	
TRPV4	Channel, cation; Membrane protein, integral; Membrane protein, multi-pass	Q9HBA0	59341	TRPV4	12q24.1	human	T175	PHOSPHORYLATION	10272405	GLLPFLLtHKKRLTD		activity, induced				9980421	1	0	0		
SLC18A3	Membrane protein, integral; Membrane protein, multi-pass; Transporter	Q62666	60422	Slc18a3		rat	S480	PHOSPHORYLATION	450965	GLLTRSRsERDVLLD	MFS_1	intracellular localization				3211; 3202	2	0	2		
KEAP1	Endoplasmic reticulum; Motility/polarity/chemotaxis; Transcription regulation; Ubiquitin conjugating system	Q9Z2X8	50868	Keap1		mouse	Y85	PHOSPHORYLATION	25123100	DVTLQVKyEDIPAAQ	BTB	protein degradation; ubiquitination; intracellular localization				25082853	1	0	0	required for the nuclear export of KEAP1, Cul3 and Rbx1	
TFAM	DNA binding protein; Transcription regulation	Q00059	7019	TFAM	10q21	human	S55	PHOSPHORYLATION	18016712	SCPKKPVsSYLRFSK	HMG_box	protein degradation; intracellular localization	transcription, inhibited		DNA(DISRUPTS)	27519609	1	2	0	localized to mitochondria,  Lon-mediated degradation	
CEP55	Cancer Testis Antigen (CTA); Cell cycle regulation	Q53EZ4	55165	CEP55	10q23.33	human	S425	PHOSPHORYLATION	457628	NREKVAAsPKSPTAA		activity, induced; molecular association, regulation	cell cycle regulation	PLK1(INDUCES)		7205	1	12	8		
VEGFR1	EC 2.7.1.112; EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Protein kinase, TK; Protein kinase, tyrosine (receptor)	P17948	2321	FLT1	13q12	human	Y1169	PHOSPHORYLATION	448208	VQQDGKDyIPINAIL		molecular association, regulation		PLCG1(INDUCES)		1402	1	0	6		
Fyn	EC 2.7.10.2; KINASE; Kinase, protein; Protein kinase, TK; Protein kinase, tyrosine (non-receptor)	P39688	14360	Fyn		mouse	Y531	PHOSPHORYLATION	447883	FTATEPQyQPGENL_		enzymatic activity, inhibited				7400	15	10	1039		
Kv7.1	Channel, potassium; Membrane protein, integral; Membrane protein, multi-pass	P51787	3784	KCNQ1	11p15.5	human	S577	PHOSPHORYLATION	456165	PSLFISVsEKSKDRG	KCNQ_channel	activity, induced				6659	1	0	0		
HUWE1	EC 6.3.2.-; EC 6.3.2.19; Ligase; UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase	EDL86311				rat	Y3007	PHOSPHORYLATION	13196101	SNTEYHKyQSNSIQI	HECT	molecular association, regulation	transcription, inhibited			12668800	1	0	0	mutation of Y3007 attenuated HUWE1 inhibition of p53-mediated transcription	
Bcl-3	Apoptosis; Nuclear receptor co-regulator; Transcription regulation	P20749	602	BCL3	19q13.1-q13.2	human	S406	PHOSPHORYLATION	3627522	PSSSPSQsPPRDPPG		protein degradation; molecular association, regulation; ubiquitination	transcription, altered; cell growth, altered	HDAC6(INDUCES); HDAC3(INDUCES); HDAC1(INDUCES)		4319	1	0	0		
PIK3R1	Enzyme, regulatory subunit; KINASE; Kinase, lipid; Motility/polarity/chemotaxis	P26450	18708	Pik3r1		mouse	S361	PHOSPHORYLATION	20831300	TFLVRDAsTKMHGDY	SH2	molecular association, regulation	signaling pathway regulation			20830900	1	1	0	;  impairs PI3K pathway activation; inhibits binding to to phospho-Tyr peptides	
NFkB-p65	DNA binding protein; Nuclear receptor co-regulator; Transcription factor	Q04206	5970	RELA	11q13	human	S281	PHOSPHORYLATION	456219	RPSDRELsEPMEFQY		intracellular localization	transcription, induced; transcription, altered			1172828; 3475702	4	0	0		
CD5	Cell surface; Membrane protein, integral	P13379	12507	Cd5		mouse	Y452	PHOSPHORYLATION	447774	ASHVDNEySQPPRNS		molecular association, regulation		PIK3R1(NOT_REPORTED)		2710	3	8	308		
TGFBR1	EC 2.7.11.30; KINASE; Kinase, protein; Membrane protein, integral; Protein kinase, Ser/Thr (receptor); Protein kinase, TKL; Receptor, misc.	P36897	7046	TGFBR1	9q22	human	T200	PHOSPHORYLATION	4325704	LPLLVQRtIARTIVL	TGF_beta_GS	phosphorylation; enzymatic activity, induced				4324303	2	0	0	T200V mutation prevented ligand-induced phosphorylation at other residues	
QIK	EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, CAMK; Protein kinase, Ser/Thr (non-receptor)	Q3LRT3	315649	Snf1lk2		rat	S586	PHOSPHORYLATION	3212040	FREGRRAsDTPLTQG			apoptosis, altered			18021012	2	18	14	overexpression of S587A increases cell death	
AT1	GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR	P30556	185	AGTR1	3q24	human	T336	PHOSPHORYLATION	467237	NLSTKMStLSYRPSD		activity, induced; molecular association, regulation; intracellular localization; receptor internalization, altered		ARRB1(INDUCES); ARRB2(INDUCES)		8345; 8199	2	0	0		
ITGB5	Cell adhesion; Membrane protein, integral; Motility/polarity/chemotaxis	P18084	3693	ITGB5	3q21.2	human	S759	PHOSPHORYLATION	14694704	REFAKFQsERSRARY	DUF3036; Integrin_b_cyt		cell motility, altered			14551414	1	0	0		
LEPR	Membrane protein, integral; Receptor, cytokine	P48356	16847	Lepr		mouse	Y1077	PHOSPHORYLATION	451292	HREKSVCyLGVTSVN		activity, induced; molecular association, regulation; phosphorylation	transcription, altered	SOCS3(INDUCES)		3516; 13270514; 4449	6	0	0	attenuation of STAT3 phosphorylation	
FBX4	Ligase; Ubiquitin conjugating system	Q9UKT5	26272	FBXO4	5p12	human	S12	PHOSPHORYLATION	453026	EPRSGTNsPPPPFSD		molecular association, regulation; ubiquitination; enzymatic activity, induced		14-3-3 epsilon(INDUCES); FBX4(INDUCES)		21261101; 4049518	2	17	0	FBX4 dimerization ; promotes cyclin D1 degradation and inhibits oncogenic transformation	
FcGR2A	Cell surface; Membrane protein, integral; Receptor, misc.	P12318	2212	FCGR2A	1q23	human	Y240	PHOSPHORYLATION	2906102	AAVVALIyCRKKRIS	TM	receptor internalization, altered				8501	1	0	0		
HER4	EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Protein kinase, TK; Protein kinase, tyrosine (receptor)	Q15303	2066	ERBB4	2q33.3-q34	human	Y1056	PHOSPHORYLATION	451500	GHSPPPAyTPMSGNQ		activity, induced; molecular association, regulation	cell growth, altered	Cbl(INDUCES); Arg(INDUCES); PIK3C2A(INDUCES); PIK3R3(INDUCES); PIK3R2(INDUCES); PIK3R1(INDUCES)		4651319; 3679; 2506306	1	1	1	critical for HER4 activity to inhibit colony formation	
tau	Cytoskeletal protein	P19332	29477	Mapt		rat	S715	PHOSPHORYLATION	449082	PVVSGDTsPRHLSNV			cytoskeletal reorganization			4214826	87	31	69		
BLNK	Adaptor/scaffold	Q8WV28	29760	BLNK	10q23.2-q23.33	human	Y84	PHOSPHORYLATION	449841	EHSDSEMyVMPAEEN		molecular association, regulation	transcription, altered	Nck2(INDUCES); PLCG2(INDUCES); PLCG1(INDUCES); Btk(INDUCES); VAV1(INDUCES)		827; 7669	4	0	0	Sites mutated alone and in combination (Y189,Y178and Y96) prevented binding of PLCG1 and mobization of Ca2+. For NF-AT transcriptional activity Y103,Y194 and Y205 residues were necessary.Tyrosine phosphoryation of BLNK induces MAPK activation. 



	
AKAP1	Adaptor/scaffold; Membrane protein, integral; Mitochondrial	Q92667	8165	AKAP1	17q22	human	S159	PHOSPHORYLATION	465541	PKGVLFSsKSAEVCK		molecular association, regulation		PPP1CA(DISRUPTS)		7971	0	0	2		
CSF2RB	Membrane protein, integral; Receptor, cytokine	P26955	12983	Csf2rb		mouse	S603	PHOSPHORYLATION	448463	LGPPQSHsLPDLPDQ		molecular association, regulation	cell growth, altered	14-3-3 zeta(INDUCES); PIK3R1(INDUCES)		7441	6	0	0	Phosphorylation of Y595 and S603 are exclusive.  S603 phosphorylation induces binding to 14-3-3 and prevents binding to Shc.	
AurA	EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor)	O14965	6790	AURKA	20q13	human	S51	PHOSPHORYLATION	457655	AQRVLCPsNSSQRVP		protein stabilization				9253	2	2	0	dephosphorylation by PPP2CA leads to the protein degradation	
RAF1	EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, Ser/Thr (non-receptor); Protein kinase, TKL	Q99N57	110157	Raf1		mouse	S259	PHOSPHORYLATION	447741	SQRQRSTsTPNVHMV		molecular association, regulation; intracellular localization; enzymatic activity, inhibited	cell growth, altered	14-3-3 beta(INDUCES); HRas(DISRUPTS); MEK1(DISRUPTS)		2268; 1846; 14654306	44	13	128		
p53	Activator protein; DNA binding protein; Motility/polarity/chemotaxis; Nuclear receptor co-regulator; Transcription factor; Tumor suppressor	P02340	22059	Tp53		mouse	K376	UBIQUITINATION	464658	QSTSRHKkTMVKKVG			transcription, altered			3141407	11	0	0	p53K6R (K378/383/369/379/367/370/R) mutant is still ubiquitinated and shows normal stability of p53 before and after DNA damage	
PAK3	EC 2.7.1.; EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, STE; Protein kinase, Ser/Thr (non-receptor)	O75914	5063	PAK3	Xq23	human	S50	PHOSPHORYLATION	448125	NKKARLRsIFPGGGD			cytoskeletal reorganization			9007	2	1	0	Mutation of any of the 4 serines/threonines to alanine reduced the AILIM/ICOS-induced elongation ratio in activated T cells.  Three sites are believed to be autophosphorylation sites, and one is believed to be an Akt1 site.  Treatment with Akt inhibitor shows a reduction in this elongation ratio.	
Spinophilin	Adaptor/scaffold; Protein phosphatase, regulatory subunit	O35274	84686	Ppp1r9b		rat	S177	PHOSPHORYLATION	448727	LLRQERAsLQDRKLD		molecular association, regulation; intracellular localization		ADRA2A(DISRUPTS)		1890; 2425209	3	1	0		
CBP	ACETYLTRANSFERASE; Acetyltransferase; DNA binding protein; EC 2.3.1.48; Motility/polarity/chemotaxis; Nuclear receptor co-regulator; Transcription, coactivator/corepressor	P45481	12914	Crebbp		mouse	T1872	PHOSPHORYLATION	474502	LMRRRMAtMNTRNVP			transcription, induced			9166	2	0	0		
PDE3A	EC 3.1.4.17; Membrane protein, integral; Membrane protein, multi-pass; Nucleotide Metabolism - purine; Phosphodiesterase	Q14432	5139	PDE3A	12p12	human	S312	PHOSPHORYLATION	456900	SKSHRRTsLPCIPRE		enzymatic activity, induced				7313807	3	12	1		
SREBP-1 iso4	DNA binding protein; Membrane protein, integral; Membrane protein, multi-pass; Transcription factor	Q9WTN3-4	20787	Srebf1		mouse	S329	PHOSPHORYLATION	7996201	KSLKDLVsACGSGGG		molecular association, regulation; activity, inhibited	transcription, altered		DNA(DISRUPTS)	7889908	1	0	0	regulates hepatic lipogenesis	
CD44	Cell adhesion; Membrane protein, integral; Motility/polarity/chemotaxis; Receptor, misc.	P16070	960	CD44	11p13	human	S697	PHOSPHORYLATION	465669	AVEDRKPsGLNGEAS	Bravo_FIGEY		cell motility, altered			8080	1	17	14	critical for chemotaxis	
ENaC-beta	Channel, sodium; Membrane protein, integral; Membrane protein, multi-pass	P37090	24767	Scnn1b		rat	S631	PHOSPHORYLATION	2228600	QPLDTMEsDSEVEAI		activity, induced; intracellular localization				2195469	1	2	0	 membrane expression of ENAC beta and gamma, and may translocate CK2 to the cell membrane.; channel activation	
Myb	DNA binding protein; Transcription factor	P01103	396244	MYB		chicken	S116	PHOSPHORYLATION	448757	KYGPKRWsVIAKHLK	Spore_III_AB	molecular association, regulation	transcription, altered		DNA(DISRUPTS)	2609	1	0	0		
SLP76	Adaptor/scaffold	Q60787	16822	Lcp2		mouse	Y112	PHOSPHORYLATION	448218	WSSFEDDyESPNDDD		molecular association, regulation; phosphorylation	cell differentiation, altered; apoptosis, altered; cytoskeletal reorganization; cell adhesion, altered; transcription, induced; transcription, altered	VAV1(INDUCES)		2425220; 1967701; 2079; 1605; 1606; 6115903	15	0	0	mutation of this site impairs thrombus formation	
cortactin	Actin binding protein; Cytoskeletal protein; Motility/polarity/chemotaxis	O70420	60465	Cttn		rat	Y383	PHOSPHORYLATION	447702	RPPSSPIyEDTAPLK			cell motility, altered; cell adhesion, altered; signaling pathway regulation			8393; 8283	26	45	713		
CD4	Cell surface; Membrane protein, integral	P06332	12504	Cd4		mouse	S432	PHOSPHORYLATION	451188	QRQAARMsQIKRLLS	Tcell_CD4_Cterm	intracellular localization				5930011	3	0	1		
PINX1	Inhibitor protein	Q96BK5	54984	PINX1	8p23	human	S117	PHOSPHORYLATION	14823407	SFSLEEKsKISKNRV		protein degradation; ubiquitination				14790317	1	1	0		
CNR1	GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR	P20272	25248	Cnr1		rat	S317	PHOSPHORYLATION	450999	IQRGTQKsIIIHTSE	7tm_1; Flavi_NS4B	activity, inhibited				3253	1	6	2	Phosphorylation of CB1 at S317 suppressed modulation of ion channels by this receptor.	
BRCA1	EC 6.3.2.-; Nuclear receptor co-regulator; Transcription, coactivator/corepressor; Tumor suppressor; UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase	P38398	672	BRCA1	17q21	human	S1542	PHOSPHORYLATION	450009	EEQQLEEsGPHDLTE		molecular association, regulation		ATM(INDUCES)		1757	1	3	0		
CREM iso3	DNA binding protein; Transcription factor	P27699	12916	Crem		mouse	S133	PHOSPHORYLATION	448412	EILSRRPsYRKILNE	pKID	activity, induced; activity, inhibited	transcription, induced; transcription, altered			2632; 11763; 2633; 1042	5	1	40	BLV LTR (bovine leukemia virus promoter).	
JunD	Motility/polarity/chemotaxis; Transcription factor	P52909	24518	Jund		rat	S100	PHOSPHORYLATION	456168	LGLLKLAsPELERLI	Jun		transcription, induced			9172; 9205	5	31	12		
phosducin	G protein regulator, misc.	P20942	25343	Pdc		rat	S6	PHOSPHORYLATION	10431700	__MEEAAsQSLEEDF	Phosducin	molecular association, regulation		GNB1(DISRUPTS); G-gamma(2)(DISRUPTS)		10144212	1	0	0		
PSD-95	Adaptor/scaffold	P31016	29495	Dlg4		rat	S415	PHOSPHORYLATION	456446	REQLMNSsLGSGTAS		protein conformation		CRIPT(DISRUPTS)		21385507	1	9	0	Y397E mutant showed dissociation, and triple mutant Y397E/S415E/S418E, had stronger dissociation. 	
JAK2	EC 2.7.10.2; KINASE; Kinase, protein; Protein kinase, TK; Protein kinase, tyrosine (non-receptor)	Q62120	16452	Jak2		mouse	Y637	PHOSPHORYLATION	470140	KFGSLDTyLKKNKNS	Pkinase_Tyr	enzymatic activity, induced				7601401	3	1	1		
PPP1R2	Inhibitor protein; Motility/polarity/chemotaxis; Protein phosphatase, regulatory subunit	P41236	5504	PPP1R2	3q29	human	S122	PHOSPHORYLATION	449053	RIQEQESsGEEDSDL	IPP-2	intracellular localization				3958	3	39	28	Phosphorylation is required for nuclear localization during S phase.	
IL22RA1	Membrane protein, integral	Q8N6P7	58985	IL22RA1	1p36.11	human	Y301	PHOSPHORYLATION	3579176	SLAQPVQySQIRVSG		molecular association, regulation		SHP-2(INDUCES)		15235209	1	1	4	necessary for IL22RA1 to mediate the IL-22-stimulated MAP kinases and STAT3 activation	
LRRK2	EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, Ser/Thr (non-receptor); Protein kinase, TKL	Q5S006	66725	Lrrk2		mouse	S910	PHOSPHORYLATION	4725893	LVKRKSNsISVGEVY		molecular association, regulation		14-3-3 beta(INDUCES); 14-3-3 theta(INDUCES); 14-3-3 zeta(INDUCES); 14-3-3 epsilon(INDUCES); 14-3-3 eta(INDUCES)		15022721; 15022728	9	8	0		
SDS3	Helicase	Q8BR65	71954	Suds3		mouse	S228	PHOSPHORYLATION	454398	RTLNKLKsPKRPASP	Exonuc_VII_L		cell growth, altered			4245	2	3	3		
MARK3 iso3	EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, CAMK; Protein kinase, Ser/Thr (non-receptor)	P27448-3	4140	MARK3	14q32.3	human	T90	PHOSPHORYLATION	3597303	AIKIIDKtQLNPTSL	Pkinase	enzymatic activity, inhibited				8987	1	0	0		
ATP1A1	EC 3.6.3.9; Hydrolase; Membrane protein, integral; Membrane protein, multi-pass	P06685	24211	Atp1a1		rat	S943	PHOSPHORYLATION	451649	ICKTRRNsVFQQGMK	Cation_ATPase_C	activity, inhibited				3959	6	3	0		
STAP2	Adaptor/scaffold	Q9UGK3	55620	STAP2	19p13.3	human	Y310	PHOSPHORYLATION	6155352	LPNQEENyVTPIGDG			transcription, altered			10294000	1	0	2		
RASSF1 iso2	Tumor suppressor	Q9NS23-2	11186	RASSF1	3p21.3	human	S131	PHOSPHORYLATION	486364	EWETPDLsQAEIEQK		molecular association, regulation	cell growth, altered	RASSF1 iso2(INDUCES); MST2(INDUCES)		12021326	3	0	0	controls cell response to DNA damage and its tumorigenic capacity	
GluR1	Channel, calcium; Channel, ligand-gated; Membrane protein, integral; Membrane protein, multi-pass	P23818	14799	Gria1		mouse	T858	PHOSPHORYLATION	3362100	NEAIRTStLPRNSGA		activity, induced				3361001	2	0	0	synaptic plasticity	
Notch 1	Membrane protein, integral; Motility/polarity/chemotaxis; Receptor, misc.; Transcription factor	Q01705	18128	Notch1		mouse	K2154	ACETYLATION	18899513	KARKPSTkGLACGSK		protein stabilization; ubiquitination				18899000	1	1	0		
P2RY4	GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR	P51582	5030	P2RY4	Xq13	human	S333	PHOSPHORYLATION	10349702	PQPRTAAsSLALVSL		receptor desensitization, altered; receptor internalization, altered				10144228	1	0	0		
Cbl	Adaptor/scaffold; EC 6.3.2.-; EC 6.3.2.19; Ligase; Motility/polarity/chemotaxis; UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase	P22681	867	CBL	11q23.3	human	Y700	PHOSPHORYLATION	448529	EGEEDTEyMTPSSRP		protein degradation; molecular association, regulation	cell motility, altered; cell growth, altered	Src(INDUCES); Crk(INDUCES); VAV1(INDUCES)		6767; 4181; 5294; 2012	9	12	484	The double mutant Y700/774F was used in this study; Src induces Cbl phosphorylation inducing Cbl degredation and alters EGFR desensitization.  	
Gab2	Adaptor/scaffold	Q9Z1S8	14389	Gab2		mouse	Y603	PHOSPHORYLATION	449788	KSTGSVDyLALDFQP		molecular association, regulation	cell differentiation, altered; cell growth, altered	SHP-2(INDUCES)		1342	6	3	45		
vinculin	Cell adhesion; Cytoskeletal protein; Motility/polarity/chemotaxis	Q64727	22330	Vcl		mouse	Y822	PHOSPHORYLATION	450873	KSFLDSGyRILGAVA	Vinculin	phosphorylation	apoptosis, altered; cell motility, altered			8887	1	26	1600	regulates ERK, PXN, and FAK phosphorylation	
JAK2	EC 2.7.10.2; KINASE; Kinase, protein; Protein kinase, TK; Protein kinase, tyrosine (non-receptor)	Q62120	16452	Jak2		mouse	Y317	PHOSPHORYLATION	7603503	TEQDVQLyCDFPDII		enzymatic activity, inhibited				7601401	1	1	0		
Kit	EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Protein kinase, TK; Protein kinase, tyrosine (receptor)	P10721	3815	KIT	4q11-q12	human	Y900	PHOSPHORYLATION	450042	EHAPAEMyDIMKTCW	Pkinase_Tyr	protein stabilization; molecular association, regulation		PIK3C2A(INDUCES); Crk(INDUCES)		2599	1	0	2		
HES6	Transcription, coactivator/corepressor	Q96HZ4	55502	HES6	2q37.3	human	S183	PHOSPHORYLATION	455670	GPGDDLCsDLEEAPE			cell cycle regulation			6180	1	0	0		
p27Kip1	Cell cycle regulation; Inhibitor protein; Protein kinase, regulatory subunit	P46527	1027	CDKN1B	12p13.1-p12	human	S83	PHOSPHORYLATION	451426	WQEVEKGsLPEFYYR		protein conformation				3627	2	0	0		
MRLC1	Contractile protein; Motility/polarity/chemotaxis	P24844	10398	MYL9	20q11.23	human	S20	PHOSPHORYLATION	1863500	KRPQRATsNVFAMFD	EF_hand_5	activity, induced; molecular association, regulation; intracellular localization	cell motility, altered; cell adhesion, altered; cytoskeletal reorganization			7117100; 4961510; 10274615; 19016907	30	27	281		
Jun	Transcription factor	P05412	3725	JUN	1p32-p31	human	S63	PHOSPHORYLATION	447686	KNSDLLTsPDVGLLK	Jun	activity, induced; molecular association, regulation; protein stabilization	apoptosis, altered; apoptosis, induced; transcription, induced; transcription, altered; cell growth, altered	JNK1(DISRUPTS); Pin1(INDUCES)	DNA(DISRUPTS)	4843006; 7397639; 6467; 6403; 5827; 14654313; 1022; 6115915; 641; 4507; 7324120; 7124704; 6324; 2333; 4652; 6417	101	19	4	induced by ERK7 activity	
MSK2	EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor)	O75676	8986	RPS6KA4	11q11-q13	human	S360	PHOSPHORYLATION	447953	PRIFQGYsFVAPSIL	Pkinase_C	enzymatic activity, induced				1264	1	1	9		
Akt1	EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor)	P31749	207	AKT1	14q32.32	human	Y315	PHOSPHORYLATION	448519	TFCGTPEyLAPEVLE	Pkinase	enzymatic activity, induced	transcription, altered			6751; 15331019	4	2	12		
PDE3A	EC 3.1.4.17; Membrane protein, integral; Membrane protein, multi-pass; Nucleotide Metabolism - purine; Phosphodiesterase	Q9Z0X4	54611	Pde3a		mouse	S291	PHOSPHORYLATION	471416	WKRRRRSsSVVAGEM		enzymatic activity, induced				9112	1	0	9	required for insulin-dependent Xenopus oocyte maturation; 
activated during oocytes maturation in mouse treated with hCG 	
RGS16	GTPase activating protein, RGS	O15492	6004	RGS16	1q25-q31	human	Y168	PHOSPHORYLATION	448652	TLMEKDSyPRFLKSP	RGS	activity, induced; protein stabilization				5754; 1847	2	0	0		
ULK1	Autophagy; EC 2.7.1.37; EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor)	O70405	22241	Ulk1		mouse	S637	PHOSPHORYLATION	3176158	FDFPKTPsSQNLLTL			autophagy, altered			17740400	1	18	36		
CCNE1	Activator protein; Nuclear receptor co-regulator	P24864	898	CCNE1	19q12	human	T395	PHOSPHORYLATION	447676	PLPSGLLtPPQSGKK		protein degradation; molecular association, regulation; ubiquitination	cell cycle regulation	FBXW7(INDUCES); SKP2(INDUCES)		10001301; 7991111; 4279; 1467; 11426; 1466; 8414	12	6	0	association in vitro and in vivo; T380 of cyclin E is necessary for for ubiquination and targeting to the proteosome. 	
Rb	Nuclear receptor co-regulator; Transcription, coactivator/corepressor; Tumor suppressor	P06400	5925	RB1	13q14.2	human	T821	PHOSPHORYLATION	447983	KISEGLPtPTKMTPR	Rb_C	molecular association, regulation	apoptosis, inhibited; cell growth, altered	Elf-1(DISRUPTS); E2F1(DISRUPTS); Rb(INDUCES); TFDP1(DISRUPTS)		7267; 25723400; 776; 777	17	16	52		
ITGB1	Cell adhesion; Cell surface; Membrane protein, integral; Motility/polarity/chemotaxis; Receptor, misc.	P09055	16412	Itgb1		mouse	T789	PHOSPHORYLATION	447709	IYKSAVTtVVNPKYE	Integrin_b_cyt		cell adhesion, altered			1685; 10425104	8	1	1		
ZO1	Adaptor/scaffold; Motility/polarity/chemotaxis	P39447	21872	Tjp1		mouse	Y1164	PHOSPHORYLATION	450401	EEQPAPAyEVHNRYR			cell cycle regulation; cell motility, altered			2790302	1	9	134		
Kv4.2	Channel, potassium; Membrane protein, integral; Membrane protein, multi-pass	Q63881		Kcnd2		rat	S447	PHOSPHORYLATION	4668101	SANAYMQsKRNGLLS	DUF3399	intracellular localization; phosphorylation				4641423	1	0	1	increases phosphorylation at T602 and T607 by ERK	
HMGCR	EC 1.1.1.34; Endoplasmic reticulum; Membrane protein, integral; Membrane protein, multi-pass; Motility/polarity/chemotaxis; Oxidoreductase; Secondary Metabolites Metabolism - terpenoid backbone biosynthesis	P51639	25675	Hmgcr		rat	S871	PHOSPHORYLATION	448568	SHMVHNRsKINLQDL		enzymatic activity, inhibited				2601	5	5	0		
AML3	DNA binding protein; Transcription factor	Q08775	12393	Runx2		mouse	S380	PHOSPHORYLATION	10892804	DPRQAQSsPPWSYDQ		protein stabilization; acetylation	transcription, altered			12021301	6	0	0	stimulates AML3 acetylation	
Cdc6	Cell cycle regulation	Q99741	990	CDC6	17q21.3	human	S54	PHOSPHORYLATION	450914	RVKALPLsPRKRLGD		protein stabilization; molecular association, regulation; intracellular localization	cell cycle regulation			27258204; 3235; 7270; 3156	9	6	0		
IRF7	DNA binding protein; Transcription factor	Q92985	3665	IRF7	11p15.5	human	S472	PHOSPHORYLATION	1276103	TQREGVSsLDSSSLS			transcription, inhibited			8586	3	0	0		
ERK3	EC 2.7.11.24; KINASE; Kinase, protein; Protein kinase, CMGC; Protein kinase, Ser/Thr (non-receptor)	Q16659	5597	MAPK6	15q21	human	S189	PHOSPHORYLATION	448267	YSHKGHLsEGLVTKW	Pkinase	molecular association, regulation; intracellular localization		MAPKAPK5(INDUCES)		19016952	5	15	2		
MDM4	EC 6.3.2.-; Ligase; UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase	O35618	17248	Mdm4		mouse	S402	PHOSPHORYLATION	474540	DLAHSSEsQEIISSA		protein degradation				11387294	9	1	0		
MCL1	Apoptosis; Channel, misc.; Inhibitor protein; Membrane protein, integral; Mitochondrial	Q07820	4170	MCL1	1q21	human	T163	PHOSPHORYLATION	455375	TDGSLPStPPPAEEE		protein stabilization; molecular association, regulation	apoptosis, induced; cell growth, altered	Pin1(INDUCES)		8630; 4646402	7	11	8		
IRS1	Adaptor/scaffold; Motility/polarity/chemotaxis	P35568	3667	IRS1	2q36	human	S639	PHOSPHORYLATION	447507	YMPMSPKsVSAPQQI		intracellular localization				8915	27	3	0	via cell fractionation experiments	
Abl	EC 2.7.1.112; EC 2.7.10.2; KINASE; Kinase, protein; Protein kinase, TK; Protein kinase, tyrosine (non-receptor)	P00519	25	ABL1	9q34.1	human	Y312	PHOSPHORYLATION	4922741	CTREPPFyIITEFMT	Pkinase_Tyr	enzymatic activity, induced				6011117	1	0	0	SH2 and catalytic domains of Fes and Abl interact with ligand, stimulating kinase activity. 	
AhR	DNA binding protein; Nuclear receptor; Transcription factor	P35869	196	AHR	7p15	human	S12	PHOSPHORYLATION	451412	SANITYAsRKRRKPV		intracellular localization	transcription, altered			3610	1	0	0	Dephosphorylated AhR enters the nucleus.  	
HIR	Channel, potassium; Membrane protein, integral; Membrane protein, multi-pass	P48050	3761	KCNJ4	22q13.1	human	T53	PHOSPHORYLATION	450871	IFTTCVDtRWRYMLM	UPF0104; IRK	activity, inhibited				3175	1	0	0	Phosphorylation dramatically inhibits channel activity.	
Kv11.1	Channel, potassium; Membrane protein, integral; Membrane protein, multi-pass; Motility/polarity/chemotaxis	Q12809	3757	KCNH2	7q36.1	human	Y475	PHOSPHORYLATION	3496802	LINFRTTyVNANEEV	Ion_trans	activity, induced				3309532	1	0	0		
MAZ	C2H2-type zinc finger protein; Transcription factor	P56270	4150	MAZ	16p11.2	human	S460	PHOSPHORYLATION	465574	PTAVGSLsGAEGVPV			transcription, induced	Myc(NOT_REPORTED)		8030	1	0	0	regulates DNA binding of MAZ to c-myc promoter element	
PITPNB	Lipid binding protein	P53812	114561	Pitpnb		rat	S262	PHOSPHORYLATION	451299	ETMRKKGsVRGTSAA		not reported				8100; 7778	5	5	22	 S261 phosphorylation does not affect PITPNB localization to Golgi.; isoform containing S261 transfers sphingomyelin more efficiently; does not have an influence on the localization of PITPNB to Golgi membranes 	
ARHGEF7	Guanine nucleotide exchange factor, Rac/Rho; Motility/polarity/chemotaxis	Q14155	8874	ARHGEF7	13q34	human	S703	PHOSPHORYLATION	455681	EEFASRKsTAALEED		activity, induced; molecular association, regulation	cytoskeletal reorganization	RAP1GDS1(DISRUPTS)		8922	3	12	2	activates ARHGEF7's exchange activity on Rac1	
CFLAR	Apoptosis	O15519	8837	CFLAR	2q33-q34	human	S193	PHOSPHORYLATION	7590803	LQAAIQKsLKDPSNN		ubiquitination				7549219	1	1	0		
MST2	Autophagy; EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, STE; Protein kinase, Ser/Thr (non-receptor)	Q13188	6788	STK3	8q22.2	human	T180	PHOSPHORYLATION	448899	DTMAKRNtVIGTPFW	Pkinase	protein processing; enzymatic activity, induced	apoptosis, altered; signaling pathway regulation			12558730; 13371800	7	0	5		
TORC1	Transcription factor	Q157S1	684527	Mect1		rat	S167	PHOSPHORYLATION	18255800	MTPTQAEsFTGGPQD	TORC_M	intracellular localization; activity, inhibited	apoptosis, altered; transcription, inhibited			18021012	1	0	0		
GluR KA2	Channel, ligand-gated; Membrane protein, integral; Membrane protein, multi-pass	Q63273	24407	Grik5		rat	T976	PHOSPHORYLATION	27535801	PTGPRELtEHE____		molecular association, regulation		PSD-95(DISRUPTS)		27519625	1	0	0	 necessary for KAR-LTD; increases expression of KARs at the plasma membrane;  reduced at dendritic spines;  increases lateral mobility of KARs	
SHP-2	EC 3.1.3.48; Motility/polarity/chemotaxis; PHOSPHATASE; Protein phosphatase, tyrosine (non-receptor)	P35235	19247	Ptpn11		mouse	Y304	PHOSPHORYLATION	451495	PNEPVSDyINANIIM	Y_phosphatase	molecular association, regulation		Grb2(INDUCES)		3675	2	1	56		
ezrin	Cytoskeletal protein; Motility/polarity/chemotaxis	P15311	7430	EZR	6q25.3	human	Y354	PHOSPHORYLATION	448105	LMLRLQDyEEKTKKA	ERM	activity, induced; molecular association, regulation	cell motility, altered; cytoskeletal reorganization	PIK3R1(INDUCES)		1080; 2461602; 2740	8	3	236	cell invasion	
HNF4 alpha	DNA binding protein; Nuclear receptor; Transcription factor	P41235	3172	HNF4A	20q13.12	human	S167	PHOSPHORYLATION	458371	VLSRQITsPVSGING	Foamy_virus_ENV; Se-cys_synth_N; Hormone_recep	molecular association, regulation	transcription, induced	PC4(INDUCES)		7350	3	1	28		
MYD88	Adaptor/scaffold	P22366	17874	Myd88		mouse	Y257	PHOSPHORYLATION	474538	KRLIPIKyKAMKKDF	TIR	molecular association, regulation	cell growth, altered	PIK3R1(INDUCES)		9230	2	0	0	required for Akt activation by CpG DNA	
RGS3	GTPase activating protein, RGS	P49796	5998	RGS3	9q32	human	S943	PHOSPHORYLATION	469926	SLRRRTHsEGSLLQE		molecular association, regulation	transcription, altered	14-3-3 zeta(INDUCES); G-alpha(q)(DISRUPTS)		8778	1	13	51		
JAK2	EC 2.7.10.2; KINASE; Kinase, protein; Protein kinase, TK; Protein kinase, tyrosine (non-receptor)	Q62120	16452	Jak2		mouse	Y813	PHOSPHORYLATION	451492	NSLFTPDyELLTEND		molecular association, regulation		SH2-B-beta(INDUCES)		3673	7	2	2		
PhLP	G protein regulator, misc.	Q13371	5082	PDCL	9q12-q13	human	S19	PHOSPHORYLATION	448824	KLQYYYSsSEDEDSD		molecular association, regulation		G-gamma(2)(INDUCES); CCT-alpha(INDUCES)		7972; 5798	3	3	3	facilitates dimerization of subunits beta and gamma of G-protein 
; PhLP phosphorylation at S18-S20 induces association of G-gamma(2) with a G-beta(1)/PhLP complex.  These PhLP phosphorylations are also required for normal G-beta/G-gamma dimer assembly.	
PPP2R5A	Motility/polarity/chemotaxis; Protein phosphatase, regulatory subunit	Q15172	5525	PPP2R5A	1q32.2-q32.3	human	S28	PHOSPHORYLATION	459127	VDGFTRKsVRKAQRQ		activity, induced; intracellular localization	apoptosis, altered			5007910	2	0	8	increases mitochondrial PP2A activity 	
DDEFL1	GTPase activating protein, ARF; Motility/polarity/chemotaxis	Q8TDY4	55616	ASAP3	1p36.12	human	Y733	PHOSPHORYLATION	462087	LDISNKTyETVASLG		molecular association, regulation	endocytosis, induced; cell motility, inhibited	Grb2(INDUCES)		21683704	1	3	10	promotes recycling of ITGB1, inhibits cell spreading 	
POLR2A	EC 2.7.7.48; EC 2.7.7.6; Nucleotide Metabolism - purine; Nucleotide Metabolism - pyrimidine; Transcription initiation complex; Transferase	P24928	5430	POLR2A	17p13.1	human	S1621	PHOSPHORYLATION	3439802	SYSPTSPsYSPTSPS	RNA_pol_Rpb1_R	molecular association, regulation; phosphorylation	transcription, altered; cell growth, altered	INTS11(INDUCES); POLR1B(INDUCES)		11999208; 25027310; 14821619; 3433207; 3433208	7	0	0	transcription of small nuclear RNA genes; snRNA expression and processing, decrease in S1616 phosphorylation; phosphorylation correlated with transcription	
eIF5	Translation; Translation initiation	P55010	1983	EIF5	14q32.32	human	S389	PHOSPHORYLATION	448029	LKEAEEEsSGGEEED	W2	molecular association, regulation	cell cycle regulation; translation, altered	eIF2-alpha(INDUCES)		3309502; 6983	3	31	43		
GluR KA2	Channel, ligand-gated; Membrane protein, integral; Membrane protein, multi-pass	Q63273	24407	Grik5		rat	S892	PHOSPHORYLATION	19014315	LSNGKLYsAGAGGDA		molecular association, regulation		PSD-95(DISRUPTS)		27519625	1	0	0	 necessary for KAR-LTD; increases expression of KARs at the plasma membrane;  reduced at dendritic spines;  increases lateral mobility of KARs	
AS160	GTPase activating protein, Rab	O60343	9882	TBC1D4	13q22.2	human	S588	PHOSPHORYLATION	455920	RMRGRLGsVDSFERS		molecular association, regulation		14-3-3 epsilon(INDUCES)		14058615	12	28	207	multiple sites (6P) mutant	
PARK2	EC 6.3.2.-; EC 6.3.2.19; Ligase; UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase	O60260	5071	PARK2	6q25.2-q27	human	S131	PHOSPHORYLATION	454421	HTDSRKDsPPAGSPA		enzymatic activity, inhibited				9380	2	1	0	reduces auto-ubiquitylation and inclusion body formation relevant to Parkinson's disease	
p53	Activator protein; DNA binding protein; Motility/polarity/chemotaxis; Nuclear receptor co-regulator; Transcription factor; Tumor suppressor	P04637	7157	TP53	17p13.1	human	S378	PHOSPHORYLATION	447534	SKKGQSTsRHKKLMF		activity, induced; molecular association, regulation; intracellular localization	cell cycle regulation; chromatin organization, altered; transcription, induced	14-3-3 zeta(INDUCES); 14-3-3 epsilon(INDUCES); 14-3-3 gamma(INDUCES); BLM(DISRUPTS); WRN(DISRUPTS)	DNA(INDUCES)	2965; 1209; 7991101; 3361014; 12300001; 5011207; 4641429	14	1	0	S376/3787 phosphorylated peptides inhibited helicase activityin vitro. S15 phosphorylated p53 colocalized with BLM in vivo.	
MDM2	EC 6.3.2.-; EC 6.3.2.19; Inhibitor protein; Ligase; UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase	Q00987	4193	MDM2	12q14.3-q15	human	S118	PHOSPHORYLATION	15714603	NQQESSDsGTSVSEN		protein degradation; molecular association, regulation; ubiquitination		FBW1B(INDUCES)		15675518	1	0	0		
p90RSK	EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor); Translation	P18653	20111	Rps6ka1		mouse	S352	PHOSPHORYLATION	447989	TSRTPRDsPGIPPSA	Pkinase_C	enzymatic activity, induced				3231	36	20	4		
BAP1	EC 3.4.19.12; Protease; Tumor suppressor; Ubiquitin conjugating system; Ubiquitin-specific protease	Q92560	8314	BAP1	3p21.31-p21.2	human	S592	PHOSPHORYLATION	477921	SIRPIQGsQGSSSPV		intracellular localization				29642900	1	2	7	nuclear localization but not associated with chromatin	
TSSK4	EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, CAMK; Protein kinase, Ser/Thr (non-receptor)	Q9D411	71099	Tssk4		mouse	T197	PHOSPHORYLATION	27138201	SLSHLSQtYCGSFAY	Pkinase	enzymatic activity, induced				27132488	1	0	0		
JAK2	EC 2.7.10.2; KINASE; Kinase, protein; Protein kinase, TK; Protein kinase, tyrosine (non-receptor)	Q62120	16452	Jak2		mouse	Y1007	PHOSPHORYLATION	448407	VLPQDKEyYKVKEPG	Pkinase_Tyr	protein degradation; enzymatic activity, induced		SOCS1(INDUCES)		8089; 8083; 13354701; 1713155; 2323; 2366	46	3	15		
ZAP	RNA binding protein; Transferase	Q8K3Y6	252832	Zc3hav1		rat	S266	PHOSPHORYLATION	4776627	EFLSPVVsPLGSGPP		activity, induced				25227647	1	7	0		
CRMP-2	Microtubule binding protein; Motility/polarity/chemotaxis	Q16555	1808	DPYSL2	8p22-p21	human	S522	PHOSPHORYLATION	448082	PASSAKTsPAKQQAP			cell motility, altered			1300300	13	19	84	increases axon length	
PARD6A	Adaptor/scaffold; Cell adhesion; Motility/polarity/chemotaxis	Q9Z101	56513	Pard6a		mouse	S345	PHOSPHORYLATION	15714600	RGDVSGFsL______			cell growth, altered			15675502	2	2	0		
PhLP	G protein regulator, misc.	Q13371	5082	PDCL	9q12-q13	human	S18	PHOSPHORYLATION	448823	EKLQYYYsSSEDEDS		molecular association, regulation		G-gamma(2)(INDUCES); CCT-alpha(INDUCES)		7972; 5798	3	4	2	facilitates dimerization of subunits beta and gamma of G-protein 
; PhLP phosphorylation at S18-S20 induces association of G-gamma(2) with a G-beta(1)/PhLP complex.  These PhLP phosphorylations are also required for normal G-beta/G-gamma dimer assembly.	
FOXC2	Apoptosis; Cell development/differentiation; DNA binding protein; Transcription factor	Q99958	2303	FOXC2	16q24.1	human	S281	PHOSPHORYLATION	3210588	NIMTLRTsPPGGELS		molecular association, regulation	transcription, altered		DNA(INDUCES)	28129300	1	6	0	implicated in vascular remodeling  in vivo	
vimentin	Cytoskeletal protein; Motility/polarity/chemotaxis	P20152	22352	Vim		mouse	S47	PHOSPHORYLATION	455455	LGSALRPsTSRSLYS	Filament_head; DUF2464		cytoskeletal reorganization			2057	2	8	10		
Ebp1	Nuclear receptor co-regulator; Transcription, coactivator/corepressor	Q6AYD3	288778	Pa2g4		rat	S360	PHOSPHORYLATION	478276	ELKALLQsSASRKTQ	TraC	molecular association, regulation; intracellular localization	cell growth, altered	Rb(DISRUPTS); Akt1(INDUCES)		11148; 17675068	4	1	0		
nAChRA7	Channel, cation; Channel, ligand-gated; Membrane protein, integral; Membrane protein, multi-pass	P36544	1139	CHRNA7	15q14	human	Y442	PHOSPHORYLATION	457467	KILEEVRyIANRFRC	Neur_chan_memb	activity, inhibited				6962	1	0	1		
ITGA4	Cell adhesion; Membrane protein, integral; Motility/polarity/chemotaxis; Receptor, misc.	P13612	3676	ITGA4	2q31.3	human	S1021	PHOSPHORYLATION	469620	QEENRRDsWSYINSK		activity, induced; molecular association, regulation; phosphorylation	cell motility, altered; cytoskeletal reorganization	PXN iso2(DISRUPTS)		8904; 8300; 2831789	7	18	94	activates Rac1	
STMN2	Cytoskeletal protein	P21818	84510	Stmn2		rat	S97	PHOSPHORYLATION	455607	AAEGRRKsQEAQVLK	Stathmin; CDC37_N	molecular association, regulation; activity, inhibited	cytoskeletal reorganization	TUBA1A(DISRUPTS); TUBB(DISRUPTS)		5546; 5533	3	1	1		
TTC5	Adaptor/scaffold	Q99LG4	219022	Ttc5		mouse	S203	PHOSPHORYLATION	12559514	TGQNPKIsQQALSAY	TPR_11	intracellular localization	apoptosis, induced	p300(INDUCES)		12482280	2	0	0	apoptosis in response to DNA damage 	
GDI1	G protein regulator, misc.; Motility/polarity/chemotaxis	P50398	25183	Gdi1		rat	S213	PHOSPHORYLATION	12607403	INRIKLYsESLARYG	GDI	molecular association, regulation		Rab4(INDUCES)		12525212	1	0	0	facilitates the membrane trafficking of AMPARs	
SLC6A4	Membrane protein, integral; Membrane protein, multi-pass; Transporter	P31645	6532	SLC6A4	17q11.2	human	T276	PHOSPHORYLATION	456508	SIWKGVKtSGKVVWV	SNF	activity, induced				970029; 9375; 6711	3	0	0		
PR	DNA binding protein; Nuclear receptor	P06401	5241	PGR	11q22-q23	human	S162	PHOSPHORYLATION	450156	PATQRVLsPLMSRSG	Prog_receptor		transcription, induced			7324125	5	3	0		
CTNNB1	Actin binding protein; Cell adhesion; Motility/polarity/chemotaxis; Nuclear receptor co-regulator; Transcription factor	Q02248	12387	Ctnnb1		mouse	S605	PHOSPHORYLATION	3545003	LFVQLLYsPIENIQR	Arm	intracellular localization				2915500	1	0	0		
IkB-alpha	DNA binding protein; Inhibitor protein	P25963	4792	NFKBIA	14q13	human	Y42	PHOSPHORYLATION	448737	DSMKDEEyEQMVKEL		activity, induced; protein degradation; molecular association, regulation	apoptosis, inhibited; transcription, altered	NFkB-p65(DISRUPTS)		6212; 2024; 2097; 1193011; 5644; 4914007	14	1	25	Phosphorylation  induces NKkB activation and IkB-alpha degradation. 	
NPAT	Cell cycle regulation; Transcription regulation	Q14207	4863	NPAT	11q22-q23	human	S775	PHOSPHORYLATION	2286404	LPTIILSsPTKSPTK			transcription, induced			2285900	1	2	0	multiple sites deletion mutant	
cPLA2	EC 3.1.1.4; EC 3.1.1.5; Lipid Metabolism - alpha-linolenic acid; Lipid Metabolism - arachidonic acid; Lipid Metabolism - ether lipid; Lipid Metabolism - glycerophospholipid; Lipid Metabolism - linoleic acid; Phospholipase	P47712	5321	PLA2G4A	1q25	human	S228	PHOSPHORYLATION	450089	ATYVAGLsGSTWYMS	PLA2_B	activity, induced; enzymatic activity, induced				4632; 1968363	4	0	0	S228 induced full activity, S505 partially	
APC	Motility/polarity/chemotaxis; Tumor suppressor	P25054	324	APC	5q21-q22	human	S1505	PHOSPHORYLATION	452096	DGFSCSSsLSALSLD	APC_crr	molecular association, regulation; phosphorylation		CTNNB1(INDUCES)		970021; 4038	1	0	0	phosphorylation by CK1 primes for S1501 phosphorylation by GSK3; based on acidic phospho-mimetic mutant	
JUB	Cell adhesion; Motility/polarity/chemotaxis; Transcription, coactivator/corepressor	Q91XC0	16475	Jub		mouse	T172	PHOSPHORYLATION	22499900	SRPCSNRtSGISMGY		molecular association, regulation		RAC1(INDUCES)		22495311	1	1	0	necessary for Rac activation by junctions	
SIRT1	Apoptosis; DEACETYLASE; Deacetylase; EC 3.5.1.-; Nuclear receptor co-regulator	Q923E4	93759	Sirt1		mouse	T522	PHOSPHORYLATION	6006905	HLSELPPtPLHISED		molecular association, regulation; acetylation; enzymatic activity, induced	apoptosis, altered	p53(DISRUPTS)		12778816	4	3	19	promotes cell survival	
H2AX	DNA binding protein; Helicase	P27661	15270	H2afx		mouse	S140	PHOSPHORYLATION	448841	GKKASQAsQEY____		activity, induced; molecular association, regulation	apoptosis, induced	MDC1(INDUCES)		2563005; 2039; 3394325	149	14	17		
GABRG2	Channel, chloride; Channel, ligand-gated; Membrane protein, integral; Membrane protein, multi-pass	P22723	14406	Gabrg2		mouse	Y411	PHOSPHORYLATION	455817	LQERDEEyGYECLDG	Neur_chan_memb	activity, induced; receptor internalization, altered				11999215	7	0	0	spatial object recognition in mice	
STXBP1	Vesicle protein	P61765	25558	Stxbp1		rat	S313	PHOSPHORYLATION	448744	SLKDFSSsKRMNTGE	Sec1; YlbD_coat	molecular association, regulation	exocytosis, altered	STX1A(DISRUPTS)		9181; 4232	5	0	0	regulates protein secretion by increasing vesicle pools replenishment after stimulation	
MDM4	EC 6.3.2.-; Ligase; UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase	O15151	4194	MDM4	1q32	human	S403	PHOSPHORYLATION	474540	DLAHSSEsQETISSM		protein degradation; molecular association, regulation; ubiquitination; intracellular localization		MDM2(DISRUPTS); USP7(DISRUPTS); MDM2(INDUCES); p53(DISRUPTS)		8635; 9981402; 25712607; 11387294; 7113	9	1	0	lower level of MDM4 ubiquitination were observed on the triple mutant S342/367/403/A; MDM4342/A367A/403A mutant is resistant to MDM2 degradation after DNA damage, but is degradated after ARF expression.   	
RYR2	Channel, ligand-gated; Membrane protein, integral; Membrane protein, multi-pass	E9Q401	20191	Ryr2		mouse	S2813	PHOSPHORYLATION	458801	ISQTSQVsIDAAHGY		activity, induced				17431535	24	5	5		
Casp1	Apoptosis; EC 3.4.22.36; Protease	P29466	834	CASP1	11q23	human	S376	PHOSPHORYLATION	469562	IFRKVRFsFEQPDGR	Peptidase_C14	enzymatic activity, induced				8321	1	0	0		
CTCF	C2H2-type zinc finger protein; Transcription factor	Q08705	396274	CTCF		chicken	S610	PHOSPHORYLATION	448304	RSKKEDSsDSEENAE			transcription, altered; cell growth, altered			1410	1	5	1		
FMR1	Translation	P35922	14265	Fmr1		mouse	S499	PHOSPHORYLATION	469583	NSEASNAsETESDHR	FXR1P_C	molecular association, regulation; phosphorylation	translation, altered	RCAN1(INDUCES)		26341712; 8386	10	2	0	induces hierarchical phosphorylation of nearby serines	
Pyk2	EC 2.7.10.2; KINASE; Kinase, protein; Nuclear receptor co-regulator; Protein kinase, TK; Protein kinase, tyrosine (non-receptor)	Q9QVP9	19229	Ptk2b		mouse	Y402	PHOSPHORYLATION	447955	CSIESDIyAEIPDET		molecular association, regulation; enzymatic activity, induced	apoptosis, induced; cell adhesion, altered; cytoskeletal reorganization	Src(INDUCES)		6206; 8197; 5543; 5178; 1173403	61	2	21	glucocorticoid induced apoptosis. ; Integrin-dependent functions are impaired in Wiskott-Aldrich Syndrome protein-deficient mouse and human neutrophils.	
NFAT90	DNA binding protein; Transcription factor	Q12906	3609	ILF3	19p13.2	human	S647	PHOSPHORYLATION	3496801	RGRGRGGsIRGRGRG		intracellular localization	translation, altered; transcription, altered			15562507; 3301225	2	0	0	regulates IL-2 production in T cells; required for NFAT90 export;  stabilizes IL-2 mRNA	
RAF1	EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, Ser/Thr (non-receptor); Protein kinase, TKL	Q99N57	110157	Raf1		mouse	S43	PHOSPHORYLATION	447744	FGYQRRAsDDGKLTD		enzymatic activity, inhibited	cell growth, altered			1846	17	8	5		
KCNN4	Channel, potassium; Membrane protein, integral; Membrane protein, multi-pass	O15554	3783	KCNN4	19q13.2	human	H358	PHOSPHORYLATION	474525	FRQVRLKhRKLREQV	CaMBD	activity, induced				8049906; 9307	4	0	0		
CSFR	EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Protein kinase, TK; Protein kinase, tyrosine (receptor)	P07333	1436	CSF1R	5q32	human	Y699	PHOSPHORYLATION	451527	DPEGGVDyKNIHLEK	Pkinase_Tyr	molecular association, regulation		PIK3CB(INDUCES)		3701	15	4	32		
CaMK4	EC 2.7.11.17; KINASE; Kinase, protein; Protein kinase, CAMK; Protein kinase, Ser/Thr (non-receptor)	Q16566	814	CAMK4	5q21.3	human	S13	PHOSPHORYLATION	2135601	VPSCSASsCSSVTAS			transcription, altered			2758	1	0	0		
GABRB1	Channel, chloride; Channel, ligand-gated; Membrane protein, integral; Membrane protein, multi-pass	P50571	14400	Gabrb1		mouse	S409	PHOSPHORYLATION	451812	IQYRKPLsSREGFGR	Neur_chan_memb	activity, induced				10144229	3	0	0		
AMPKA2	Autophagy; EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, CAMK; Protein kinase, Ser/Thr (non-receptor)	P54646	5563	PRKAA2	1p31	human	T172	PHOSPHORYLATION	448026	SDGEFLRtSCGSPNY	Pkinase	enzymatic activity, induced				27902353; 1975; 4774	47	9	19	S399 is required for metformin activation of AMPK.	
IFI16	Transcription factor	P15092	15951	Ifi204		mouse	S179	PHOSPHORYLATION	1848001	STAQKRKsMREEETG		intracellular localization				1713157	1	0	0		
diaphanous 2 iso4	Cytoskeletal protein; Motility/polarity/chemotaxis	Q17R91	1730	DIAPH2	Xq21.33	human	S196	PHOSPHORYLATION	18707506	CLESLRVsLTSNPVS	Drf_GBD		cell cycle regulation; chromatin organization, altered; cytoskeletal reorganization			18668219	1	1	0	mutation of this site disrupts metaphase chromosome alignment	
LEF-1	DNA binding protein; Transcription factor	Q9UJU2	51176	LEF1	4q23-q25	human	S42	PHOSPHORYLATION	471384	EKIFAEIsHPEEEGD	CTNNB1_binding	molecular association, regulation	transcription, induced	CTNNB1(INDUCES)		9089	1	0	4		
MCM2	DNA binding protein; EC 3.6.4.12	P49736	4171	MCM2	3q21	human	S108	PHOSPHORYLATION	456310	DVEELTAsQREAAER	MCM2_N	molecular association, regulation	chromatin organization, altered		DNA(INDUCES)	9204	8	15	77	MMCM2 phosphorylated forms are differentially bound to chromatin. 	
GR	DNA binding protein; Mitochondrial; Nuclear receptor; Transcription factor	P06537	14815	Nr3c1		mouse	S212	PHOSPHORYLATION	447967	DLEFSAGsPGKETNE	GCR		transcription, induced			21683716	13	2	0		
MAX iso2	DNA binding protein; Transcription factor	P61244-2	4149	MAX	14q23	human	S11	PHOSPHORYLATION	449308	NDDIEVEsDADKRAH	DUF342; TFIIA; Filament; Myosin_tail_1; HAUS6_N; IncA; Fib_alpha; GAS	activity, inhibited	transcription, altered			9408	4	9	0	phosphorylation-deficient mutant inhibits transcription more efficiently	
CDH1	Cell adhesion; Membrane protein, integral; Motility/polarity/chemotaxis; UBIQUITIN LIGASE; Ubiquitin ligase	P09803	12550	Cdh1		mouse	S842	PHOSPHORYLATION	15754600	FDYEGSGsEAASLSS	Cadherin_C	molecular association, regulation		CTNNB1(INDUCES)		15754200	3	1	0		
MEF2D	DNA binding protein; Transcription factor	O89038	81518	Mef2d		rat	T145	PHOSPHORYLATION	10359101	PNFAMPVtVPVSNQS	HJURP_C	activity, inhibited	apoptosis, altered; transcription, inhibited			10353938	1	0	0		
SSH1	EC 3.1.3.16; EC 3.1.3.48; PHOSPHATASE; Protein phosphatase, dual-specificity	Q8WYL5	54434	SSH1	12q24.11	human	S402	PHOSPHORYLATION	10989184	MGVSRSAsTVIAYAM	DSPc	molecular association, regulation; enzymatic activity, inhibited	cell motility, altered			18837516	1	1	7		
mGluR1	GPCR, family 3; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR	P23385	24414	Grm1		rat	T695	PHOSPHORYLATION	453089	GSKKKICtRKPRFMS	7tm_3	receptor desensitization, altered				3200	1	0	0	Rapid desensitization of mGluR1 is dependent on T695 phosphorylation.	
GSTP1	EC 2.5.1.18; Other Amino Acids Metabolism - glutathione; Transferase; Xenobiotic Metabolism - drug metabolism - cytochrome P450; Xenobiotic Metabolism - metabolism by cytochrome P450	P09211	2950	GSTP1	11q13	human	Y199	PHOSPHORYLATION	463460	AFLASPEyVNLPING		protein conformation; enzymatic activity, induced				7613720	1	1	23		
CTNNB1	Actin binding protein; Cell adhesion; Motility/polarity/chemotaxis; Nuclear receptor co-regulator; Transcription factor	P35222	1499	CTNNB1	3p21	human	S552	PHOSPHORYLATION	472273	QDTQRRTsMGGTQQQ		intracellular localization	cell motility, altered; transcription, induced	14-3-3 zeta(INDUCES)		14654301; 7397628	10	30	9	 S552-P  translocates from cell contacts to the cytosol and nucleus. Constitutively active Akt enhanced tumor cell invasion.; localized at cell-cell contacts	
DYNLT1	Microtubule binding protein; Motility/polarity/chemotaxis; Motor protein	P63172	6993	DYNLT1	6q25.2-q25.3	human	S82	PHOSPHORYLATION	470041	AGLHTASsCFWDSST	Tctex-1	molecular association, regulation		rhodopsin(INDUCES); DNCLI1(DISRUPTS)		8917	2	0	1	S82E mutant TCTEL1 is excluded, while S82A mutant protein is impaired in release, from dynein complexes; S82E and S82A mutants cause relocalization of rhodopsin	
CCDC6	Apoptosis; Cytoskeletal protein	Q16204	8030	CCDC6	10q21	human	S359	PHOSPHORYLATION	3197330	SPIPYTPsPSSSRPI		protein degradation; molecular association, regulation		FBXW7(INDUCES)		27132403	1	6	22		
CNR1	GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR	P21554	1268	CNR1	6q14-q15	human	S425	PHOSPHORYLATION	999609	TAQPLDNsMGDSDCL		molecular association, regulation; protein conformation		ARRB2(INDUCES)		970022	0	4	0		
KCNJ8	Channel, potassium; Membrane protein, integral; Membrane protein, multi-pass	Q63664	25472	Kcnj8		rat	S397	PHOSPHORYLATION	471151	NSMRRSNsIRRNNSS		activity, inhibited				1172871	1	1	0		
CREB	DNA binding protein; Transcription factor	P16220	1385	CREB1	2q34	human	S271	PHOSPHORYLATION	14159739	PGVVMASsPALPTQP		molecular association, regulation	transcription, induced	CBP(INDUCES)		14780517	3	2	0		
PKD2	EC 2.7.11.13; KINASE; Kinase, protein; Motility/polarity/chemotaxis; Protein kinase, CAMK; Protein kinase, Ser/Thr (non-receptor)	Q9BZL6	25865	PRKD2	19q13.3	human	S876	PHOSPHORYLATION	448800	QGLAERIsVL_____		enzymatic activity, induced				5940; 1963	4	4	1		
MAPKAPK2	EC 2.7.1.-; EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, CAMK; Protein kinase, Ser/Thr (non-receptor)	P49137	9261	MAPKAPK2	1q32	human	T334	PHOSPHORYLATION	448273	QSTKVPQtPLHTSRV		activity, induced; enzymatic activity, induced				812; 7309	21	4	19		
KHSRP	RNA binding protein	Q92945	8570	KHSRP	19p13.3	human	S132	PHOSPHORYLATION	482096	SQGDSISsQLGPIHP		activity, induced; molecular association, regulation				18410826	1	2	9	binds to and functions in pri-miRNA processing	
FAK	EC 2.7.1.112; EC 2.7.10.2; KINASE; Kinase, protein; Protein kinase, TK; Protein kinase, tyrosine (non-receptor)	O35346	25614	Ptk2		rat	Y397	PHOSPHORYLATION	447887	SVSETDDyAEIIDEE		activity, induced; molecular association, regulation; intracellular localization; phosphorylation; enzymatic activity, induced	apoptosis, altered; apoptosis, inhibited; cytoskeletal reorganization; cell adhesion, altered; transcription, altered	Lyn(INDUCES); NMDAR2A(INDUCES); NMDAR2B(INDUCES)		2461604; 2878; 2255; 4894708; 6101; 19016901; 1962901; 1088; 2879; 5718	234	21	470		
BLNK	Adaptor/scaffold	Q8WV28	29760	BLNK	10q23.2-q23.33	human	Y178	PHOSPHORYLATION	447716	LLEDEADyVVPVEDN		molecular association, regulation	transcription, altered	Nck2(INDUCES); PLCG2(INDUCES); PLCG1(INDUCES); Btk(INDUCES); VAV1(INDUCES)		827; 7669	2	1	7	Sites mutated alone and in combination (Y189,Y178and Y96) prevented binding of PLCG1 and mobization of Ca2+. For NF-AT transcriptional activity Y103,Y194 and Y205 residues were necessary.Tyrosine phosphoryation of BLNK induces MAPK activation. 



	
N-CoR1	Nuclear receptor co-regulator; Transcription, coactivator/corepressor	Q60974	20185	Ncor1		mouse	S2345	PHOSPHORYLATION	2888300	KLINKSNsRKSKSPI		molecular association, regulation		14-3-3 beta(INDUCES)		2858606	1	0	0		
MEK1	EC 2.7.12.2; KINASE; Kinase, protein; Protein kinase, STE; Protein kinase, dual-specificity	Q01986	170851	Map2k1		rat	S298	PHOSPHORYLATION	448284	RTPGRPLsSYGMDSR	Pkinase	intracellular localization; phosphorylation; enzymatic activity, induced	cell cycle regulation; cytoskeletal reorganization; cell adhesion, altered			9269; 4914029	16	0	0	activation of MEK1 and ERK1/2; Phosphorylation stimulates autophosphorylation on S217/S222.	
ADD2	Cytoskeletal protein; Motility/polarity/chemotaxis	Q05764	24171	Add2		rat	S725	PHOSPHORYLATION	449803	KKKEKVEs_______		intracellular localization	cytoskeletal reorganization			2346	2	0	0		
MDM4	EC 6.3.2.-; Ligase; UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase	O15151	4194	MDM4	1q32	human	S342	PHOSPHORYLATION	470031	SKLTHSLsTSDITAI	Cript	protein degradation; molecular association, regulation; ubiquitination; intracellular localization		MDM2(DISRUPTS); USP7(DISRUPTS); 14-3-3 theta(INDUCES); MDM2(INDUCES); p53(DISRUPTS)		8914; 8635; 9981402; 25712607; 11387294; 7113	11	2	3	lower level of MDM4 ubiquitination were observed on the triple mutant S342/367/403/A; MDM4342/A367A/403A mutant is resistant to MDM2 degradation after DNA damage, but is degradated after ARF expression.   	
NPY1R	GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR	P21555	29358	Npy1r		rat	T356	PHOSPHORYLATION	2815302	IAMSTMHtDVSKTSL		receptor desensitization, altered; receptor internalization, altered				4358	1	0	1	may be an artifact of the truncation mutants	
CTNNB1	Actin binding protein; Cell adhesion; Motility/polarity/chemotaxis; Nuclear receptor co-regulator; Transcription factor	P35222	1499	CTNNB1	3p21	human	T41	PHOSPHORYLATION	447583	GIHSGATtTAPSLSG		protein degradation; molecular association, regulation; intracellular localization	cytoskeletal reorganization; cell adhesion, altered; transcription, altered; cell growth, altered	CBLL1(INDUCES)		14146308; 6842213; 1732; 14654301; 12068405; 8971	44	3	0	 promotes centrosomal cohesion	
CABP1	Adaptor/scaffold; Calcium-binding protein; Inhibitor protein	Q9NZU7	9478	CABP1	12q24.31	human	S323	PHOSPHORYLATION	12521706	TNGDGEIsTSELREA	EF_hand_5; POTRA_2	activity, induced				12482289	1	0	0		
Gab1	Adaptor/scaffold; Motility/polarity/chemotaxis	Q9QYY0	14388	Gab1		mouse	Y307	PHOSPHORYLATION	447944	MRHVSISyDIPPTPG		molecular association, regulation	cell differentiation, altered; cell growth, altered	PLCG1(INDUCES)		1102	5	1	40		
RFA2	DNA replication	P15927	6118	RPA2	1p35	human	S11	PHOSPHORYLATION	1854600	SGFESYGsSSYGGAG		intracellular localization	cell growth, altered			9042	3	0	0	7xAlanine mutant has defect in down regulating DNA synthesis following UV treatment. 7xAspartate mutant did not localize to S-phase foci.	
FLT3	EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Protein kinase, TK; Protein kinase, tyrosine (receptor)	P36888	2322	FLT3	13q12	human	Y599	PHOSPHORYLATION	448643	VDFREYEyDLKWEFP		molecular association, regulation; enzymatic activity, induced; phosphorylation		Src(INDUCES); SHP-2(INDUCES)		2594; 8124	5	0	2		
p300	ACETYLTRANSFERASE; Acetyltransferase; EC 2.3.1.48; Motility/polarity/chemotaxis; Nuclear receptor co-regulator; Transcription, coactivator/corepressor	Q09472	2033	EP300	22q13.2	human	S89	PHOSPHORYLATION	447592	SELLRSGsSPNLNMG		molecular association, regulation; enzymatic activity, inhibited	transcription, induced; transcription, inhibited	PPAR-gamma(DISRUPTS); RARG(DISRUPTS); TR-beta1(DISRUPTS); RXRA(DISRUPTS)		6252; 2756; 1347; 4471	8	1	0		
IL4R	Membrane protein, integral; Receptor, cytokine	P24394	3566	IL4R	16p12.1-p11.2	human	Y497	PHOSPHORYLATION	451065	VIAGNPAyRSFSNSL			apoptosis, inhibited			3287	3	0	0		
SSTR3	GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR	P30936	171044	Sstr3		rat	T357	PHOSPHORYLATION	456711	GSGPPEKtEEEEDEE		receptor internalization, altered				4062	1	0	0		
IRF8	DNA binding protein; Transcription factor	Q02556	3394	IRF8	16q24.1	human	Y110	PHOSPHORYLATION	2299203	ISEPYKVyRIVPEEE	IRF		transcription, altered; transcription, inhibited			2195716; 2300800	2	0	0		
FOXO3A	Autophagy; DNA binding protein; Transcription factor	Q9WVH4	56484	Foxo3		mouse	T32	PHOSPHORYLATION	448602	QSRPRSCtWPLQRPE		molecular association, regulation; intracellular localization	cell cycle regulation; apoptosis, altered; apoptosis, inhibited; cytoskeletal reorganization; transcription, inhibited; cell growth, altered	14-3-3 beta(INDUCES); p300(DISRUPTS); 14-3-3 zeta(INDUCES)		2896; 4649; 9395; 5738; 2148; 679; 7550836	57	4	80	-/- MEM55B KO MEFs increased proliferation and tumor growth  in KO mice.	
KLF1	C2H2-type zinc finger protein; DNA binding protein; Transcription factor	P46099	16596	Klf1		mouse	T23	PHOSPHORYLATION	457383	TLGQFLDtQEDFLKW		activity, induced	transcription, altered			7058	1	0	0		
DYN2	EC 3.6.5.5; Hydrolase; Microtubule binding protein; Motility/polarity/chemotaxis; Vesicle protein	P50570	1785	DNM2	19p13.2	human	S848	PHOSPHORYLATION	3059607	GIPPGVPsRRPPAAP		molecular association, regulation; intracellular localization		PIK3C2A(DISRUPTS)		8429	1	0	0		
WAVE1	Cytoskeletal protein; Motility/polarity/chemotaxis	Q92558	8936	WASF1	6q21	human	Y125	PHOSPHORYLATION	457673	PIPLQETyDVCEQPP		molecular association, regulation	cytoskeletal reorganization	Arp3(INDUCES)		7296	1	0	0		
AKAP1	Adaptor/scaffold; Membrane protein, integral; Mitochondrial	Q92667	8165	AKAP1	17q22	human	S151	PHOSPHORYLATION	465540	PLECPLSsPKGVLFS		molecular association, regulation		PPP1CA(DISRUPTS)		7971	0	4	0		
RAN	G protein; G protein, monomeric, Ran; Motility/polarity/chemotaxis; Nuclear export; Nuclear receptor co-regulator	P62826	5901	RAN	12q24.3	human	S135	PHOSPHORYLATION	469112	DRKVKAKsIVFHRKK	Ras	molecular association, regulation; intracellular localization	cell cycle regulation	RanGAP1(DISRUPTS); RCC1(DISRUPTS)		15278801; 8270	2	7	1		
JAK2	EC 2.7.10.2; KINASE; Kinase, protein; Protein kinase, TK; Protein kinase, tyrosine (non-receptor)	O60674	3717	JAK2	9p24	human	Y119	PHOSPHORYLATION	470132	VLYRIRFyFPRWYCS		protein stabilization; enzymatic activity, inhibited		EpoR(DISRUPTS)		9048	2	0	0		
FPR1	GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Motility/polarity/chemotaxis; Receptor, GPCR	P21462	2357	FPR1	19q13.4	human	S332	PHOSPHORYLATION	450851	TEDSTQTsDTATNST		molecular association, regulation; receptor desensitization, altered; receptor internalization, altered		ARRB2(INDUCES)		7979; 3130	3	0	0		
UBF	DNA binding protein; Transcription factor	P25977	25574	Ubtf		rat	T201	PHOSPHORYLATION	448505	DIPEKPKtPQQLWYT	HMG_box		transcription, inhibited			1393	1	6	1		
RFC1	DNA replication	D3ZFT1	89809	Rfc1		rat	S69	PHOSPHORYLATION	452680	KKRIIYDsDSESEET		intracellular localization	transcription, inhibited			8890	1	32	5		
CITED1	Nuclear receptor co-regulator	P97769	12705	Cited1		mouse	S65	PHOSPHORYLATION	27937113	NGVPTSSsGSTSPIG	CITED	intracellular localization	cell differentiation, induced			27780046	1	0	0	S63/64/65/67/69/73/79/80/84A mutation in CITED1 inhibits its translocation into the nucleus and osteoblasts differentiation	
CDK1	EC 2.7.11.22; EC 2.7.11.23; KINASE; Kinase, protein; Motility/polarity/chemotaxis; Protein kinase, CMGC; Protein kinase, Ser/Thr (non-receptor)	P06493	983	CDK1	10q21.1	human	Y15	PHOSPHORYLATION	447610	EKIGEGTyGVVYKGR	Pkinase	molecular association, regulation; enzymatic activity, inhibited; enzymatic activity, altered	cell cycle regulation; apoptosis, inhibited	Cdc25C(DISRUPTS)		4829207; 627; 14654305; 1172819; 6032; 5488; 7309812; 14148611; 3811; 6769; 3244; 3662; 631; 8108; 12662604; 7981800; 4829209; 7613729; 11424230; 6770	128	78	3867		
BubR1	EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor)	O60566	701	BUB1B	15q15	human	T680	PHOSPHORYLATION	484623	IEDSREAtHSSGFSG		molecular association, regulation	cell cycle regulation	PPP2R5A(INDUCES)		27132456	2	0	0	 T680 is independent of attachment status and may correlate with lack of interkinetochore tension.; kinetochore-microtubule attachment	
CNR1	GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR	P21554	1268	CNR1	6q14-q15	human	S429	PHOSPHORYLATION	999608	LDNSMGDsDCLHKHA		molecular association, regulation; protein conformation		ARRB2(INDUCES)		970022	0	3	0		
PIKFYVE	Carbohydrate Metabolism - inositol phosphate; EC 2.7.1.150; EC 2.7.1.68; Kinase, lipid; Motility/polarity/chemotaxis	Q9Y2I7	200576	PIKFYVE	2q34	human	S307	PHOSPHORYLATION	457532	PARNRSAsITNLSLD		enzymatic activity, induced				7158	3	25	133		
MEK2	EC 2.7.12.2; KINASE; Kinase, protein; Protein kinase, STE; Protein kinase, dual-specificity	P36507	5605	MAP2K2	19p13.3	human	S226	PHOSPHORYLATION	448074	LIDSMANsFVGTRSY	Pkinase	enzymatic activity, induced				5930044	43	9	181		
CDK5	EC 2.7.1.37; EC 2.7.11.22; KINASE; Kinase, protein; Protein kinase, CMGC; Protein kinase, Ser/Thr (non-receptor)	P49615	12568	Cdk5		mouse	Y15	PHOSPHORYLATION	448022	EKIGEGTyGTVFKAK	Pkinase	enzymatic activity, induced				5930006; 1009	14	26	875		
MDM2	EC 6.3.2.-; EC 6.3.2.19; Inhibitor protein; Ligase; UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase	Q00987	4193	MDM2	12q14.3-q15	human	S253	PHOSPHORYLATION	2132107	SVEFEVEsLDSEDYS		activity, induced				4379	2	1	0	promotes p53 degradation	
NUP98 iso2	Motility/polarity/chemotaxis; Nucleoporin	P52948-2	4928	NUP98	11p15.5	human	T653	PHOSPHORYLATION	478067	IAKPIPQtPESAGNK		intracellular localization				18331300	1	14	11	as multiple sites (13PM) mutant 	
p53	Activator protein; DNA binding protein; Motility/polarity/chemotaxis; Nuclear receptor co-regulator; Transcription factor; Tumor suppressor	P04637	7157	TP53	17p13.1	human	S15	PHOSPHORYLATION	447490	PSVEPPLsQETFSDL	P53_TAD	acetylation; protein stabilization; molecular association, regulation; activity, inhibited; phosphorylation; activity, induced; intracellular localization; protein conformation	cell cycle regulation; apoptosis, altered; cell growth, inhibited; apoptosis, induced; transcription, induced; transcription, altered; chromatin organization, altered; transcription, inhibited; cell growth, altered	PKHF1(INDUCES); BLM(DISRUPTS); CBP(INDUCES); MDM2(DISRUPTS); MDC1(DISRUPTS); PPP2R5C(INDUCES); MDM2(INDUCES); WRN(DISRUPTS); NFkB-p65(INDUCES)	DNA(INDUCES)	6461; 5010605; 26341743; 1172819; 5011204; 5642; 5250; 2619004; 1163202; 5967; 15658720; 4775; 4313621; 19016925; 1934801; 5011207; 5248; 5963; 5260; 5004504; 5197; 6005; 2619003; 3394304; 5681; 6404; 2466207; 5257; 5682; 6466; 5011206; 6115915; 7213; 2437; 3475707; 18378508; 5950; 1213; 5004513; 731; 1211; 5650; 4971005; 14146301	347	2	0		
NPHS1	Cell adhesion; Immunoglobulin superfamily; Membrane protein, integral	Q9QZS7	54631	Nphs1		mouse	Y1232	PHOSPHORYLATION	469566	YEDPRGIyDQVAADM		molecular association, regulation	cytoskeletal reorganization	Nck1(INDUCES)		2195712	8	0	0		
CCNE1	Activator protein; Nuclear receptor co-regulator	P24864	898	CCNE1	19q12	human	S399	PHOSPHORYLATION	454414	GLLTPPQsGKKQSSG		protein degradation; molecular association, regulation; intracellular localization		FBXW7(INDUCES)		4278; 4279; 11426	4	2	1		
MUC1	Actin binding protein; Cell adhesion; Membrane protein, integral; Motility/polarity/chemotaxis; Nuclear receptor co-regulator	P15941	4582	MUC1	1q21	human	Y1203	PHOSPHORYLATION	454878	IFPARDTyHPMSEYP	IncA	activity, induced; molecular association, regulation; intracellular localization	cell motility, altered	AP2M1(INDUCES); AP1G1(INDUCES); PIK3R1(INDUCES)		12008; 4364; 7697; 11964	5	3	349	nuclear localization;  Phosphorylation enhanced invasion in vitro, through Matrigel. ; Y1203 phosphorylation is necessary for binding of PI3KR1 and phosphorylation of AKt S473.	
Ikaros	C2H2-type zinc finger protein; DNA binding protein; Transcription factor	Q03267	22778	Ikzf1		mouse	S392	PHOSPHORYLATION	451352	PSNSCQDsTDTESNA		activity, inhibited	cell cycle regulation		DNA(DISRUPTS)	3559	1	0	3		
HRas	G protein; G protein, monomeric, Ras; Motility/polarity/chemotaxis	P01112	3265	HRAS	11p15.5	human	T35	PHOSPHORYLATION	450197	FVDEYDPtIEDSYRK	Ldh_1_N; Ras		apoptosis, induced			2856	1	0	0		
GPSM2	G protein regulator, misc.	Q8VDU0	76123	Gpsm2		mouse	S408	PHOSPHORYLATION	4766076	AKLGRRHsMENLELM		molecular association, regulation		DLG1(INDUCES)		25229706	2	12	9	Fluorescence Polarization	
SOCS3	Inhibitor protein	O14543	9021	SOCS3	17q25.3	human	Y204	PHOSPHORYLATION	450446	VNGHLDSyEKVTQLP	SOCS_box	protein degradation; molecular association, regulation	transcription, altered	TCEB1(DISRUPTS)		8821; 2999	4	2	12		
ROS	EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Protein kinase, TK; Protein kinase, tyrosine (receptor)	P08922	6098	ROS1	6q22	human	Y2334	PHOSPHORYLATION	454392	GKPEGLNyACLTHSG		molecular association, regulation		SHP-1(INDUCES)		4262	1	3	17	Mutation of Y2334 reduced constitutive association of ROS with SHP-1.	
CLTC	Motility/polarity/chemotaxis; Vesicle protein	Q00610	1213	CLTC	17q11-qter	human	Y1477	PHOSPHORYLATION	448069	LFITEEDyQALRTSI	Clathrin	molecular association, regulation; intracellular localization		Syk(INDUCES)		1034; 7324306	2	6	160		
CETN2	Calcium-binding protein; Cell cycle regulation; DNA repair	P41208	1069	CETN2	Xq28	human	T118	PHOSPHORYLATION	28735101	KLFDDDEtGKISFKN	LETM1; SRI; EF_hand_6	intracellular localization				28722133	1	0	0	localization to the centrosome, capacity to form linear structures	
WNK1	EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor)	Q9H4A3	65125	WNK1	12p13.3	human	S1261	PHOSPHORYLATION	483845	AGRRFIVsPVPESRL		molecular association, regulation		OSR1(DISRUPTS); STLK3(DISRUPTS)		2653903	1	7	3		
Bcl-11B	C2H2-type zinc finger protein; Nuclear receptor co-regulator	Q99PV8	58208	Bcl11b		mouse	S318	PHOSPHORYLATION	4772870	PGTPPLFsPPPRHHL		molecular association, regulation		SENP1(INDUCES)		25573548	0	4	26		
SSH1	EC 3.1.3.16; EC 3.1.3.48; PHOSPHATASE; Protein phosphatase, dual-specificity	Q8WYL5	54434	SSH1	12q24.11	human	S937	PHOSPHORYLATION	455274	SNLTRSSsSDSIHSV		molecular association, regulation; intracellular localization; activity, inhibited	cell motility, altered	14-3-3 beta(INDUCES)		18837516; 9160402; 4499	3	10	13		
NDUFS4	EC 1.6.5.3; EC 1.6.99.3; Energy Metabolism - oxidative phosphorylation; Mitochondrial; Oxidoreductase	O43181	4724	NDUFS4	5q11.1	human	S173	PHOSPHORYLATION	2103602	WNKRTRVsTK_____	ETC_C1_NDUFA4	intracellular localization				1968365	2	1	0		
GCH1	Cofactor and Vitamin Metabolism - folate biosynthesis; EC 3.5.4.16; Hydrolase	P30793	2643	GCH1	14q22.1-q22.2	human	S81	PHOSPHORYLATION	487495	AYSSILSsLGENPQR		molecular association, regulation; enzymatic activity, induced		GCHFR(DISRUPTS)		11424231	4	0	0		
SPAG5	Cell cycle regulation	Q96R06	10615	SPAG5	17q11.2	human	T937	PHOSPHORYLATION	460416	ADEEPEStPVPLLGS		intracellular localization				1172873	1	1	0	required for SPAG5 localization to the spindle apparatus during mitosis	
CACNA1E	Channel, calcium; Membrane protein, integral; Membrane protein, multi-pass	Q07652	54234	Cacna1e		rat	S1995	PHOSPHORYLATION	455594	GGRERGRsKERKHLL		activity, induced				5534	1	0	0	potentiation of Ca(2+) currents	
MEF2D	DNA binding protein; Transcription factor	O89038	81518	Mef2d		rat	S149	PHOSPHORYLATION	10359103	MPVTVPVsNQSSMQF	HJURP_C	activity, inhibited	apoptosis, altered; transcription, inhibited			10353938	1	0	0		
PTS	Cofactor and Vitamin Metabolism - folate biosynthesis; EC 4.2.3.12; Lyase; Mitochondrial	Q03393	5805	PTS	11q22.3	human	S19	PHOSPHORYLATION	450662	AQVSRRIsFSASHRL	PTPS	enzymatic activity, induced				3127	1	8	1		
F3	Cell surface; Membrane protein, integral	P13726	2152	F3	1p22-p21	human	S285	PHOSPHORYLATION	451611	RKAGVGQsWKENSPL	stn_TNFRSF12A; Baculo_11_kDa	intracellular localization; protein conformation; phosphorylation	apoptosis, altered; cell motility, altered; cell growth, altered			3741; 2195478; 4427; 18410814; 3740; 13164211	7	0	0	promotes angiogenesis; accelerates the incorporation of F3 into microparticles and induces S290 phosphorylation	
NCoA2	Motility/polarity/chemotaxis; Transcription, coactivator/corepressor	Q15596	10499	NCOA2	8q13.3	human	S499	PHOSPHORYLATION	4728850	MSPGVAGsPRIPPSQ			transcription, induced			22723912	1	7	0		
HEC1	Cell cycle regulation	O14777	10403	NDC80	18p11.32	human	S165	PHOSPHORYLATION	449867	LGYPFALsKSSMYTV	Ndc80_HEC; Cluap1		cell cycle regulation			21040917; 3301235; 2412	3	0	0		
ROCK2	EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor)	P70336	19878	Rock2		mouse	Y722	PHOSPHORYLATION	464192	LADKNKIyESIEEAK		molecular association, regulation	cell motility, altered; cytoskeletal reorganization	RhoA(DISRUPTS)		15562532	2	3	80		
Myc	DNA binding protein; Transcription factor	P01108	17869	Myc		mouse	T400	PHOSPHORYLATION	450962	VVILKKAtAYILSIQ	HLH	molecular association, regulation; activity, inhibited	cell cycle regulation; apoptosis, inhibited; transcription, altered; transcription, inhibited; cell growth, altered	MAX(DISRUPTS)		12524163; 3233	3	0	0	mutation of this site enhances epidermal differentiation	
PTGIR	GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR	P43119	5739	PTGIR	19q13.3	human	S328	PHOSPHORYLATION	450985	TPLSQLAsGRRDPRA		receptor desensitization, altered				3249	3	0	0	S328A mutant had markedly reduced level of desensitization	
PDE4B	EC 3.1.4.17; Nucleotide Metabolism - purine; Phosphodiesterase	P14646	24626	Pde4b		rat	S133	PHOSPHORYLATION	449097	GHSQRREsFLYRSDS		enzymatic activity, induced				2126	2	8	0		
GLP1R	GPCR, family 2; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR	P32301	25051	Glp1r		rat	S431	PHOSPHORYLATION	451366	RLNIQRDsSMKPLKC		receptor desensitization, altered				3574	1	0	0		
CPT1A	EC 2.3.1.21; Lipid Metabolism - fatty acid; Membrane protein, integral; Membrane protein, multi-pass; Mitochondrial; Transferase	P32198	25757	Cpt1a		rat	S741	PHOSPHORYLATION	479870	FHISSKFsSPETDSH	Carn_acyltransf	enzymatic activity, induced				8396	1	1	0	in vitro	
SP1	C2H2-type zinc finger protein; DNA binding protein; Transcription factor	Q01714	24790	Sp1		rat	T740	PHOSPHORYLATION	448227	SEGSGTAtPSALITT			transcription, induced			20655012	13	1	0	induced by carbon monoxide	
ZAP70	EC 2.7.10.2; KINASE; Kinase, protein; Protein kinase, TK; Protein kinase, tyrosine (non-receptor)	P43403	7535	ZAP70	2q12	human	Y292	PHOSPHORYLATION	447586	DTLNSDGyTPEPARI		protein degradation; molecular association, regulation; intracellular localization; enzymatic activity, inhibited; phosphorylation	cell adhesion, altered; transcription, altered; cell growth, altered	Cbl(INDUCES)		1310; 808; 3767; 12057; 8899; 852	8	12	455	leads to decreased LAT, Cbl, CD3-Zeta, and PLC-gamma-1 phosphorylation; inhibits Ca(2+) mobilization; inhibits PI3K activation and adhesion	
SHP-2	EC 3.1.3.48; Motility/polarity/chemotaxis; PHOSPHATASE; Protein phosphatase, tyrosine (non-receptor)	Q06124	5781	PTPN11	12q24	human	Y546	PHOSPHORYLATION	448492	SKRKGHEyTNIKYSL	DUF1092	molecular association, regulation; enzymatic activity, induced	cell motility, altered; cytoskeletal reorganization; cell adhesion, altered; transcription, altered	SHP-2(INDUCES); Grb2(NOT_REPORTED); Grb2(INDUCES)		6156; 7325706; 17613013; 1361; 823; 1173022	22	13	386	Individual mutation of either site reduced SHP-2 activity. Mutation of Y546 and Y584 deceased tumor cell invasion.	
HSP90B	Chaperone	P08238	3326	HSP90AB1	6p12	human	S255	PHOSPHORYLATION	449266	PKIEDVGsDEEDDSG	HSP90	activity, induced; molecular association, regulation	apoptosis, altered	APAF(DISRUPTS)		2831748	5	79	364		
ACF	Hydrolase; RNA binding protein; RNA processing	Q923K9	170912	A1cf		rat	S368	PHOSPHORYLATION	473055	PATKGHLsNRALIRT		activity, induced				9151	1	0	0	enhances ApoB mRNA editing	
PKD1	Autophagy; EC 2.7.11.13; KINASE; Kinase, protein; Motility/polarity/chemotaxis; Protein kinase, CAMK; Protein kinase, Ser/Thr (non-receptor)	Q15139	5587	PRKD1	14q11	human	S742	PHOSPHORYLATION	448590	GEKSFRRsVVGTPAY	Pkinase	molecular association, regulation; enzymatic activity, induced	cell differentiation, altered; cell motility, altered; transcription, altered	IKKB(INDUCES); ASK1(INDUCES); PKCD(INDUCES); JNK1(INDUCES)		18410803; 5785; 3615; 5762; 4752; 2512009; 4248203	47	27	23		
PAK1	EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, STE; Protein kinase, Ser/Thr (non-receptor)	P35465	29431	Pak1		rat	S144	PHOSPHORYLATION	448170	SNSQKYMsFTDKSAE		enzymatic activity, induced				738	8	15	126		
p53	Activator protein; DNA binding protein; Motility/polarity/chemotaxis; Nuclear receptor co-regulator; Transcription factor; Tumor suppressor	P02340	22059	Tp53		mouse	S20	PHOSPHORYLATION	447529	PLSQETFsGLWKLLP	P53_TAD	activity, induced; molecular association, regulation; protein stabilization	cell cycle regulation; apoptosis, altered; cell growth, altered	MDM2(DISRUPTS)		17613009; 5258; 7932	109	1	0		
tau iso3	Cytoskeletal protein	P10636-3	4137	MAPT	17q21.1	human	S271	PHOSPHORYLATION	449081	GAEIVYKsPVVSGDT		molecular association, regulation	cytoskeletal reorganization			5955602	96	26	90	regulates association with membrane	
tau iso8	Cytoskeletal protein	P10636-8	4137	MAPT	17q21.1	human	T205	PHOSPHORYLATION	447933	SSPGSPGtPGSRSRT		O-GlcNAc glycosylation; molecular association, regulation; intracellular localization; protein conformation	cytoskeletal reorganization			5955610; 5955607; 17630402; 8165400; 6115906; 3579	55	13	26	hyperphosphorylation of this site decreases O-GlcNAcylation of tau ; The amount of tau in partticulate fraction increased in R406W and V337M mutants compared to WT.; Phosphotylated sites found in the somato-dendritic campartment but not in the axon, where tau was not phosphorylated (T205 and T217),  or not simultaneously phosphorylated (T231 and 235). ; Pseudophosphorylation mutants S199E, T212E, S214E, double mutant T212E/S214E, and triple mutant S199E/202E/T205E showed increased filament mass at equilibrium in vitro, as compared to WT tau. S212E mutant showed longer filament lengths compared to WT in vitro.	
Borealin	Cell cycle regulation	Q53HL2	55143	CDCA8	1p34.3	human	S219	PHOSPHORYLATION	460351	YNISGNGsPLADSKE	Borealin; Axin_b-cat_bind		cell cycle regulation			15278802	3	28	2		
HSF1	DNA binding protein; Transcription factor	Q00613	3297	HSF1	8q24.3	human	T142	PHOSPHORYLATION	449066	DSVTKLLtDVQLMKG	DUF247; DUF2365	activity, induced; molecular association, regulation	transcription, altered	HSF1(INDUCES)		2107	1	0	0		
Syk	EC 2.7.10.2; KINASE; Kinase, protein; Protein kinase, TK; Protein kinase, tyrosine (non-receptor)	P43405	6850	SYK	9q22	human	S295	PHOSPHORYLATION	7445408	GIISRIKsYSFPKPG		protein degradation; ubiquitination	cell cycle regulation; carcinogenesis, induced			25347030	1	1	15		
ezrin	Cytoskeletal protein; Motility/polarity/chemotaxis	P15311	7430	EZR	6q25.3	human	Y146	PHOSPHORYLATION	448758	KEVHKSGyLSSERLI	FERM_M	molecular association, regulation; phosphorylation	cell motility, altered; cell adhesion, altered; cytoskeletal reorganization; cell growth, altered			7109; 2740	9	1	0		
GAREM	Adaptor/scaffold	Q9H706	64762	GAREM	18q12.1	human	Y453	PHOSPHORYLATION	450613	PGKSELPyEELWLEE		molecular association, regulation	cell growth, altered	SHP-2(INDUCES); Grb2(INDUCES)		9689401	1	11	89		
Ets-2	DNA binding protein; Transcription factor	P15037	23872	Ets2		mouse	T72	PHOSPHORYLATION	447688	SCELPLLtPCSKAVM		activity, induced	apoptosis, inhibited; transcription, induced; transcription, altered			4788; 2747; 5398	9	0	0	Inflammation was attenuated in the Ets2 A72/A72 Hcph me-v/me-v mice	
PLD2	EC 3.1.4.4; Lipid Metabolism - ether lipid; Lipid Metabolism - glycerophospholipid; Motility/polarity/chemotaxis; Phospholipase	O14939	5338	PLD2	17p13.1	human	S243	PHOSPHORYLATION	456497	RWLVVKDsFLLYMCL	PH	enzymatic activity, induced				6687	1	1	0		
Cdc25A	EC 3.1.3.48; Motility/polarity/chemotaxis; PHOSPHATASE; Protein phosphatase, dual-specificity	P30304	993	CDC25A	3p21	human	S79	PHOSPHORYLATION	450247	QRMGSSEsTDSGFCL		protein degradation; molecular association, regulation; ubiquitination; phosphorylation		BTRC(INDUCES)		2952; 14146303; 10353922	3	0	0	S76, S79, and S82 phosphorylation affect binding to BTRC; S79 phosphorylation by CK1-A primes for S82 phosphorylation by CK1-A;  S79 phosphorylation is dependent on S76.	
LLGL2	Cell cycle regulation	Q6P1M3	3993	LLGL2	17q25.1	human	S653	PHOSPHORYLATION	13197200	LKKSLRQsFRRMRRS		intracellular localization				12660605	1	5	2	localization to cell periiphery and regulation of cell polarization	
CEACAM1	Cell adhesion; Immunoglobulin superfamily; Membrane protein, integral; Motility/polarity/chemotaxis	P13688	634	CEACAM1	19q13.2	human	Y493	PHOSPHORYLATION	447777	NKMNEVTySTLNFEA	DUF2668	molecular association, regulation		ITGB3(INDUCES)		6427	7	1	0		
NYAP2	Cell development/differentiation	Q8BM65	241134	Nyap2		mouse	Y277	PHOSPHORYLATION	455101	PEEEEPVyIEMVGNI		molecular association, regulation		PIK3R1(INDUCES)		25020801	1	0	47	localization to the neuronal plasma membrane, interaction with WAVE complex	
EXO1	EC 3.1.-.-; Hydrolase	Q9UQ84	9156	EXO1	1q42-q43	human	S714	PHOSPHORYLATION	482301	CNIKLLDsQSDQTSK		protein degradation				1223901	1	2	3		
E2A iso2	DNA binding protein; Transcription factor	P15923-2	6929	TCF3	19p13.3	human	T355	PHOSPHORYLATION	455166	NFSSSPStPVGSPQG		molecular association, regulation	transcription, induced	NEUROD1(INDUCES)		8116	3	2	21		
PML	Transcription factor; Tumor suppressor; Ubiquitin conjugating system	P29590	5371	PML	15q22	human	S38	PHOSPHORYLATION	451470	EGRQPSPsPSPTERA		sumoylation	apoptosis, altered			5354446	2	5	0	induces sumoylation	
SPRED1	Inhibitor protein	Q924S8	114715	Spred1		mouse	Y420	PHOSPHORYLATION	18899302	IVPCMCCyVPLRMCH	Sprouty		cell differentiation, altered; signaling pathway regulation			18837514	1	0	0	inhibits the Ras/ERK pathway	
PrlR	Membrane protein, integral; Receptor, cytokine	P05710	24684	Prlr		rat	Y599	PHOSPHORYLATION	450273	LQLGRLDyLDPTCFM		phosphorylation	transcription, altered			2980; 3912	3	0	3		
p53	Activator protein; DNA binding protein; Motility/polarity/chemotaxis; Nuclear receptor co-regulator; Transcription factor; Tumor suppressor	P04637	7157	TP53	17p13.1	human	T211	PHOSPHORYLATION	25535400	EYLDDRNtFRHSVVV	P53	protein degradation; ubiquitination	cell cycle regulation; carcinogenesis, induced; apoptosis, inhibited; transcription, inhibited			25347042	1	0	0		
Jun	Transcription factor	P05412	3725	JUN	1p32-p31	human	T95	PHOSPHORYLATION	1988300	ITTTPTPtQFLCPKN	Jun	activity, induced	apoptosis, altered; transcription, altered			1968304	1	0	0	required for c-Jun mediated cell death;  regulates transcription by controlling T91/T93 phosphorylation	
CACNG2	Channel, calcium; Membrane protein, integral; Membrane protein, multi-pass	O88602	12300	Cacng2		mouse	T321	PHOSPHORYLATION	451273	NTANRRTtPV_____		molecular association, regulation		PSD-93(DISRUPTS)		3493	3	0	0		
lamin A/C	Cytoskeletal protein	P02545	4000	LMNA	1q22	human	S392	PHOSPHORYLATION	452606	ERLRLSPsPTSQRSR	DUF3584; IncA	activity, induced; intracellular localization	cell cycle regulation			4641430; 7523	7	61	83	dominant negative mitotic affects, and mitotic assembly and disassembly of lamin; nuclear lamin disassemby	
CAMK1B	EC 2.7.11.17; KINASE; Kinase, protein; Protein kinase, CAMK; Protein kinase, Ser/Thr (non-receptor)	Q6P2M8	139728	PNCK	Xq28	human	T171	PHOSPHORYLATION	18637400	QAGNMLGtACGTPGY	Pkinase	enzymatic activity, induced				18410859	1	0	1		
IRS1	Adaptor/scaffold; Motility/polarity/chemotaxis	P35570	25467	Irs1		rat	S24	PHOSPHORYLATION	455604	GYLRKPKsMHKRFFV	PH	molecular association, regulation; intracellular localization	cell growth, altered		Other(DISRUPTS)	1969107	2	1	0	disrupts binding to PI(4,5)P2 in vitro	
Kv11.1 iso5	Channel, potassium; Membrane protein, integral; Membrane protein, multi-pass; Motility/polarity/chemotaxis	Q12809_VAR_014388	3757	KCNH2	7q36.1	human	T897	PHOSPHORYLATION	4839200	SFRRRTDtDTEQPGE		activity, inhibited				4641418	1	1	2	reduces basal channel current  amplitude	
Chk2	EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, CAMK; Protein kinase, Ser/Thr (non-receptor)	O96017	11200	CHEK2	22q12.1	human	T378	PHOSPHORYLATION	981402	HSKILGEtSLMRTLC	Pkinase	intracellular localization				15658725	2	1	1	chromatin targeting of S372, S379, T389, singly and T383/389, T378/S379	
REM2	G protein; G protein, monomeric, RGK	Q8VEL9	140743	Rem2		mouse	S332	PHOSPHORYLATION	1211204	AKFFKQRsRSCHDLS		molecular association, regulation; intracellular localization		14-3-3 beta(DISRUPTS)		1172800	1	0	0		
tau iso8	Cytoskeletal protein	P10636-8	4137	MAPT	17q21.1	human	S422	PHOSPHORYLATION	449083	GSIDMVDsPQLATLA		O-GlcNAc glycosylation; molecular association, regulation; protein processing	cytoskeletal reorganization	tau(INDUCES)		4420; 9223; 8165400; 2014201	28	4	0		
VASP	Cytoskeletal protein; Motility/polarity/chemotaxis	P50552	7408	VASP	19q13.32	human	S157	PHOSPHORYLATION	448379	EHIERRVsNAGGPPA		activity, induced; intracellular localization	cytoskeletal reorganization; cell adhesion, altered; transcription, inhibited; cell growth, altered	SPTAN1(DISRUPTS)		5955624; 5955623; 5358615; 3413; 4214811; 15571604	35	4	0	 S238 phosphorylation inhibits growth.; Phosphorylation at S156 is stimulates growth; reduces the number of HSV-1 infected cells; H. pylori-induced cell elongation	
DGKA	EC 2.7.1.107; Kinase, lipid; Lipid Metabolism - glycerolipid; Lipid Metabolism - glycerophospholipid; Motility/polarity/chemotaxis	P20192	397097	DGKA		pig	Y217	PHOSPHORYLATION	22874703	KRFPRPVyCNLCESS	C1_1; Prok-RING_1	intracellular localization				22723937	1	0	2	Y217 phosphorylation is necessary for serum induce export from the nucleus to cytoplasm.	
VANGL2	Adaptor/scaffold; Membrane protein, integral; Membrane protein, multi-pass	Q91ZD4	93840	Vangl2		mouse	S82	PHOSPHORYLATION	18460400	VTGTSEHsISHDDLT	Strabismus	activity, induced; protein stabilization				18410837	1	1	0		
Rb	Nuclear receptor co-regulator; Transcription, coactivator/corepressor; Tumor suppressor	P06400	5925	RB1	13q14.2	human	S811	PHOSPHORYLATION	448717	IYISPLKsPYKISEG	Rb_C	molecular association, regulation	cell cycle regulation; transcription, altered; cell growth, altered	E2F1(DISRUPTS); Abl iso2(DISRUPTS)		776; 6906; 4759; 5309405; 777; 6276	49	20	73		
TIF1A	Transcription initiation complex	Q9NYV6	54700	RRN3	16p12	human	T200	PHOSPHORYLATION	455599	IARYVPStPWFLMPI	RRN3	molecular association, regulation; intracellular localization; activity, inhibited	transcription, inhibited	TAF1B(DISRUPTS); POLR1B(DISRUPTS)		5540	1	0	0		
CLOCK	ACETYLTRANSFERASE; Acetyltransferase; DNA binding protein; EC 2.3.1.48; Transcription factor	O08785	12753	Clock		mouse	S38	PHOSPHORYLATION	3927522	KDKAKRVsRNKSEKK	HLH	protein degradation; intracellular localization	transcription, inhibited		DNA(DISRUPTS)	7889909	1	1	0	inhibits transcription	
APOBEC1	Cell cycle regulation; EC 3.5.4.-; Hydrolase; RNA binding protein; RNA processing	P41238	339	APOBEC1	12p13.1	human	S47	PHOSPHORYLATION	448433	YEIKWGMsRKIWRSS	APOBEC_N	enzymatic activity, induced				1371	1	0	0		
PEDF	Inhibitor protein; Secreted; Secreted, signal peptide	P36955	5176	SERPINF1	17p13.3	human	S114	PHOSPHORYLATION	455232	ALYYDLIsSPDIHGT	Serpin	molecular association, regulation	apoptosis, altered; carcinogenesis, altered; cell motility, altered	LEPR(INDUCES)		18410809	2	0	0		
GCSFR	Membrane protein, integral; Receptor, cytokine	P40223	12986	Csf3r		mouse	Y728	PHOSPHORYLATION	451101	LPALVQAyVLQGDPR		activity, induced				3890	1	0	0	Receptors mutant for Y728 or Y753 could neither transduce growth-inhibitory signals nor induce the neutrophil-specific myeloperoxidase (MPO) gene. A Y728 mutant did not induce morphological changes in cells.	
HSP20	Chaperone	O14558	126393	HSPB6	19q13.12	human	S16	PHOSPHORYLATION	450706	PSWLRRAsAPLPGLS	Crystallin		apoptosis, inhibited; cytoskeletal reorganization			25573564; 4641417; 9610	15	17	2		
tau iso8	Cytoskeletal protein	P10636-8	4137	MAPT	17q21.1	human	S235	PHOSPHORYLATION	449080	VVRTPPKsPSSAKSR		molecular association, regulation; intracellular localization; phosphorylation	cytoskeletal reorganization	TUBA4A(DISRUPTS); Fyn(DISRUPTS)		2365406; 17630402; 7021	31	19	22	regulates phosphorylation of tau S199 and S262; Phosphotylated sites found in the somato-dendritic campartment but not in the axon, where tau was not phosphorylated (T205 and T217),  or not simultaneously phosphorylated (T231 and 235). 	
villin	Actin binding protein; Motility/polarity/chemotaxis	P09327	7429	VIL1	2q35	human	Y46	PHOSPHORYLATION	469582	SFFDGDCyIILAIHK	Gelsolin		cytoskeletal reorganization			8883	2	0	1		
IRF3	DNA binding protein; Transcription factor	Q14653	3661	IRF3	19q13.3-q13.4	human	S173	PHOSPHORYLATION	6370303	PCPQPLRsPSLDNPT		phosphorylation	transcription, altered			6337817	5	2	0		
SREBP-2	DNA binding protein; Membrane protein, integral; Membrane protein, multi-pass; Transcription factor	Q12772	6721	SREBF2	22q13	human	S455	PHOSPHORYLATION	451008	SIDSEPGsPLLDDAK			transcription, induced			3258	2	0	0		
KIF2C	Cancer Testis Antigen (CTA); Microtubule binding protein; Motility/polarity/chemotaxis; Motor protein	Q91636	380006	kif2c		frog	T95	PHOSPHORYLATION	451107	SQNHKRKtISKIPAP		molecular association, regulation; intracellular localization	cytoskeletal reorganization		DNA(DISRUPTS)	3361009	4	1	3		
BKR2	GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR	P30411	624	BDKRB2	14q32.1-q32.2	human	S373	PHOSPHORYLATION	447664	SMGTLRTsISVERQI		receptor desensitization, altered				1355	2	2	0		
OSMR	Membrane protein, integral; Receptor, cytokine	Q99650	9180	OSMR	5p13.1	human	Y945	PHOSPHORYLATION	1930202	EAPHCSEyKMQMAVS		phosphorylation				2704330	2	0	0	important for STAT3 activation	
Blk	EC 2.7.10.2; KINASE; Kinase, protein; Protein kinase, TK; Protein kinase, tyrosine (non-receptor)	P16277	12143	Blk		mouse	Y495	PHOSPHORYLATION	447607	YTATEGQyELQP___		protein stabilization; enzymatic activity, inhibited	cell growth, altered			1656; 2606	2	0	16	Constitutively active mutant developed lymphomas. Tyrosine phosphorylated proteins such as PLC-gamma and PI3K,  were seen in tumors.	
RCC1	Guanine nucleotide exchange factor, Ras	P18754	1104	RCC1	1p36.1	human	S20	PHOSPHORYLATION	2850003	PADAIPKsKKVKVSH		molecular association, regulation		KPNA4(DISRUPTS)		2831773	1	0	0		
CLASP2	Cytoskeletal protein; Motility/polarity/chemotaxis	O75122	23122	CLASP2	3p22.3	human	S541	PHOSPHORYLATION	24976300	RESSRDTsPVRSFQP			cytoskeletal reorganization			23940901	1	3	0		
MOB1B	Activator protein; Protein kinase, regulatory subunit	Q7L9L4	92597	MOB1B	4q13.3	human	T12	PHOSPHORYLATION	3545000	FGSRSSKtFKPKKNI		molecular association, regulation; phosphorylation	cell cycle regulation; cell growth, altered	NDR1(INDUCES); NDR2(INDUCES); LATS1(INDUCES); LATS2(INDUCES)		11424218; 3301221	2	0	0		
ROCK2	EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor)	Q28021	282041	ROCK2		cow	S1099	PHOSPHORYLATION	1732202	QAQIAEEsQIRIELQ		enzymatic activity, induced	cell cycle regulation			12177	1	0	0	alanine mutation of all 4 sites	
SIRT1	Apoptosis; DEACETYLASE; Deacetylase; EC 3.5.1.-; Nuclear receptor co-regulator	Q96EB6	23411	SIRT1	10q21.3	human	S540	PHOSPHORYLATION	4770118	HVSEDSSsPERTSPP		acetylation; enzymatic activity, induced	cell cycle regulation			5930046	1	5	3		
HMGA1	DNA binding protein	Q8K585	117062	Hmga1		rat	S64	PHOSPHORYLATION	3136103	PRGRPKGsKNKGTAK		molecular association, regulation			DNA(DISRUPTS)	8553	1	1	0		
LHX3	DNA binding protein; Transcription factor	Q9UBR4	8022	LHX3	9q34.3	human	T63	PHOSPHORYLATION	455294	LKCSDCHtPLAERCF	LIM	activity, induced	transcription, induced			4438	1	0	0	no change in binding to DNA or to certain proteins (NLI, PIT1, or MRG1)	
p70S6K	EC 2.7.11.-; EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor); Translation	P23443	6198	RPS6KB1	17q23.1	human	S427	PHOSPHORYLATION	450014	ESVKEKFsFEPKIRS		enzymatic activity, induced				2563; 2561	5	3	0		
IKKB	EC 2.7.11.10; KINASE; Kinase, protein; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor)	O88351	16150	Ikbkb		mouse	S692	PHOSPHORYLATION	5735033	GQLMSQPsSACDSLP		molecular association, regulation; phosphorylation		PPP2R3C(INDUCES)		17675011	1	0	1	interaction with PPP2R3C (aka G4-1) downregulates IKK-beta activity;  S181 phosphorylation increased in S679/682/689/692/697/701/705A mutant	
CEP250	Cell cycle regulation	Q9BV73	11190	CEP250	20q11.22	human	S2394	PHOSPHORYLATION	4728460	LHHSLSHsLLAVAQA			cell cycle regulation			15235230	1	2	0		
CA9	EC 4.2.1.1; Energy Metabolism - nitrogen; Lyase; Membrane protein, integral	Q16790	768	CA9	9p13.3	human	S448	PHOSPHORYLATION	3197489	RGTKGGVsYRPAEVA		enzymatic activity, inhibited				21683702	1	0	0		
Notch 1	Membrane protein, integral; Motility/polarity/chemotaxis; Receptor, misc.; Transcription factor	Q01705	18128	Notch1		mouse	K2150	ACETYLATION	18899502	TQGKKARkPSTKGLA		protein stabilization; ubiquitination				18899000	1	1	0		
P130Cas	Adaptor/scaffold; Motility/polarity/chemotaxis	Q63767	25414	Bcar1		rat	Y764	PHOSPHORYLATION	448400	GWMEDYDyVHLQGKE	DUF3513	molecular association, regulation		Fyn(INDUCES)		2636	2	2	23		
POU2AF1	Transcription, coactivator/corepressor	Q16633	5450	POU2AF1	11q23.1	human	S184	PHOSPHORYLATION	10239701	FPWPQPLsTLPTSTL	PD-C2-AF1		transcription, induced			10144207	1	0	0		
MTSS1	Adaptor/scaffold; Motility/polarity/chemotaxis	Q8R1S4	211401	Mtss1		mouse	Y398	PHOSPHORYLATION	473757	LPDYAHYyTIGPGMF			cytoskeletal reorganization			9305	1	0	3		
TNNI3	Actin binding protein; Motility/polarity/chemotaxis; Motor protein	P19429	7137	TNNI3	19q13.4	human	S24	PHOSPHORYLATION	448424	APIRRRSsNYRAYAT	Troponin-I_N	molecular association, regulation	cytoskeletal reorganization	TNNC1(DISRUPTS)		7362300; 2391	33	4	16	muscle contraction	
SUFU	Adaptor/scaffold; Transcription, coactivator/corepressor	Q9UMX1	51684	SUFU	10q24.32	human	S346	PHOSPHORYLATION	4786848	RAPSRKDsLESDSST	SUFU_C	protein stabilization; intracellular localization; phosphorylation				18410834	1	12	3		
P70S6KB	EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor); Translation	Q9Z1M4	58988	Rps6kb2		mouse	T420	PHOSPHORYLATION	468357	RLNSSPRtPISPLKF		phosphorylation				1172822	1	3	3		
RALBP1	GTPase activating protein, Rac/Rho	Q15311	10928	RALBP1	18p11.3	human	T297	PHOSPHORYLATION	3136101	ACGRTTEtEKVQEFQ	Macoilin; RhoGAP	activity, induced; protein conformation				8781	1	0	0		
MKP-1	EC 3.1.3.16; EC 3.1.3.48; Motility/polarity/chemotaxis; PHOSPHATASE; Protein phosphatase, dual-specificity	P28562	1843	DUSP1	5q34	human	S296	PHOSPHORYLATION	457717	KQRRSIIsPNFSFMG	DSPc	protein degradation; molecular association, regulation		SKP2(INDUCES)		7315	1	0	0	MKP-1 is a substrate for Skp2 ligase	
PCAF	ACETYLTRANSFERASE; Acetyltransferase; EC 2.3.1.48; Nuclear receptor co-regulator	Q92831	8850	KAT2B	3p24	human	K416	ACETYLATION	458984	GSSSPACkASSGLEA		enzymatic activity, induced				7551	1	0	0	in vitro	
DBNL	Actin binding protein; Motility/polarity/chemotaxis	Q9UJU6	28988	DBNL	7p13	human	T291	PHOSPHORYLATION	476604	PFLQKQLtQPETHFG	UPF0560	molecular association, regulation		14-3-3 beta(INDUCES)		21683737	1	20	58	mutation of this site prevents 14-3-3 binding (pan-14-3-3 antibody)	
caldesmon	Actin binding protein	Q05682	800	CALD1	7q33	human	S789	PHOSPHORYLATION	448466	QSVDKVTsPTKV___		intracellular localization	cell motility, altered; cytoskeletal reorganization			12778807; 11975; 7289	15	9	0		
MAGE-A11	Cancer Testis Antigen (CTA); Transcription, coactivator/corepressor	P43364	4110	MAGEA11	Xq28	human	S174	PHOSPHORYLATION	2028416	ESPSPPQsPQEESFS	MAGE_N	molecular association, regulation	transcription, induced	AR(INDUCES)		11189911	2	0	0	stimulates MAGE-A11 interaction with AR and increases its transcriptional activity	
STAT3	DNA binding protein; Motility/polarity/chemotaxis; Nuclear receptor co-regulator; Transcription factor	P52631	25125	Stat3		rat	S727	PHOSPHORYLATION	448191	NTIDLPMsPRTLDSL		activity, induced; molecular association, regulation; intracellular localization	cell differentiation, altered; apoptosis, altered; transcription, induced; transcription, altered	SP1(INDUCES)	DNA(NOT_REPORTED)	5410112; 6301; 7119510; 7910522; 6914; 2014203	121	22	66		
FBXW7	Motility/polarity/chemotaxis; UBIQUITIN LIGASE; Ubiquitin conjugating system	Q969H0	55294	FBXW7	4q31.3	human	S25	PHOSPHORYLATION	25126710	SLRGNPSsSQVDEEQ	Astro_capsid; Nop14	protein degradation	cytoskeletal reorganization			25082807	1	1	0	Phosphorylation prevents ubiquitin-dependent degradation of cyclin E and subsequent centriole duplication.	
STAT1	DNA binding protein; Transcription factor	P42224	6772	STAT1	2q32.2	human	Y701	PHOSPHORYLATION	447754	DGPKGTGyIKTELIS		activity, induced; molecular association, regulation; intracellular localization	cell cycle regulation; cell differentiation, altered; transcription, induced; transcription, inhibited; transcription, altered; cell growth, altered	STAT2(INDUCES); PIAS1(INDUCES)	DNA(INDUCES); DNA(DISRUPTS)	5410103; 6464; 4805; 7119508; 5745; 5820; 5410102; 1283; 11495; 4614200; 3411; 6019; 6909; 6284; 7991141; 5957	124	4	61	ATRA induced effects ; Unphosphorylated Stat1 binds to IRF-1 and regulates constitutive gene expression . ; PIAS1 inhibits DNA binding activity of STAT1.	
RPT6	Nuclear receptor co-regulator; Proteasome complex; Ubiquitin conjugating system	P62198	81827	Psmc5		rat	S120	PHOSPHORYLATION	483970	RVALRNDsYTLHKIL			cytoskeletal reorganization			25573561	6	1	0	proteasome-dependent dendritic spine growth	
RFC1	DNA replication	D3ZFT1	89809	Rfc1		rat	S245	PHOSPHORYLATION	468617	TKKARKDsEEGESFS			transcription, induced			8890	1	14	12		
AP-2 alpha	DNA binding protein; Transcription factor	P05549	7020	TFAP2A	6p24	human	S429	PHOSPHORYLATION	20797701	TDNNAKSsDKEEKHR		protein stabilization	transcription, induced			20755825	1	0	0	induces AP-2 alpha transcription	
BARD1	EC 6.3.2.-; EC 6.3.2.19; Ligase; Tumor suppressor; UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase	Q99728	580	BARD1	2q34-q35	human	T734	PHOSPHORYLATION	465471	DSDQRFCtQYIIYED	BRCT		RNA stability, altered			7995	1	0	1	inhibits mRNA processing 	
Abl	EC 2.7.1.112; EC 2.7.10.2; KINASE; Kinase, protein; Protein kinase, TK; Protein kinase, tyrosine (non-receptor)	P00519	25	ABL1	9q34.1	human	S618	PHOSPHORYLATION	1779804	APTPPKRsSSFREMD		molecular association, regulation; phosphorylation; enzymatic activity, induced		Abi-2(DISRUPTS)		1713156	1	0	0	interaction in vitro and in vivo;  phosphorylation of this site enhances the association and phosphorylation of the Abl substrate, Crk.	
ASK1	EC 2.7.11.25; KINASE; Kinase, protein; Protein kinase, STE; Protein kinase, Ser/Thr (non-receptor)	Q99683	4217	MAP3K5	6q22.33	human	S966	PHOSPHORYLATION	447736	NEYLRSIsLPVPVLV		molecular association, regulation; enzymatic activity, inhibited	apoptosis, altered; apoptosis, induced; apoptosis, inhibited; transcription, altered	14-3-3 beta(INDUCES); 14-3-3 zeta(INDUCES); TXN(INDUCES); 14-3-3 gamma(INDUCES)		11999212; 6115915; 1163000; 3625; 923; 6702306; 3414	12	1	1		
GPR77	GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR	Q9P296	27202	GPR77	19q13.33	human	S323	PHOSPHORYLATION	9819900	GQDESVDsKKSTSHD		activity, induced; receptor internalization, altered; intracellular localization				9721204	1	0	0		
NFkB-p100	DNA binding protein; Transcription factor	Q00653	4791	NFKB2	10q24	human	S866	PHOSPHORYLATION	450166	TAEVKEDsAYGSQSV		molecular association, regulation; protein processing		IKKA(INDUCES)		4270; 2785	5	0	0		
Myt1	EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, Other; Protein kinase, dual-specificity	Q99640	9088	PKMYT1	16p13.3	human	T455	PHOSPHORYLATION	11331003	RTVGSTStPRSRCTP		molecular association, regulation		Pin1(INDUCES)		7981800	1	1	7		
NKCC1	Membrane protein, integral; Membrane protein, multi-pass; Transporter	P55011	6558	SLC12A2	5q23.3	human	T217	PHOSPHORYLATION	455546	LRTFGHNtMDAVPRI	AA_permease_N	activity, induced				8682; 5431	6	8	30		
PDGFRA	EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Protein kinase, TK; Protein kinase, tyrosine (receptor)	P16234	5156	PDGFRA	4q12	human	Y574	PHOSPHORYLATION	448438	PDGHEYIyVDPMQLP		molecular association, regulation		Src(INDUCES)		2852641	2	2	16		
ROMK iso2	Channel, potassium; Membrane protein, integral; Membrane protein, multi-pass	P35560-2		Kcnj1		rat	S25	PHOSPHORYLATION	449605	RQRARLVsKEGRCNI	IRK	activity, induced				2462000	8	0	0	phosphorylation of at least two serines necessary for channel activity	
FOXG1	DNA binding protein; Transcription factor	P55316	2290	FOXG1	14q13	human	S19	PHOSPHORYLATION	482880	MIPKSSFsINSLVPE		intracellular localization	cell differentiation, altered			11771	1	0	0		
PDGFRB	EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Protein kinase, TK; Protein kinase, tyrosine (receptor)	P09619	5159	PDGFRB	5q33.1	human	S1104	PHOSPHORYLATION	454229	PRAEAEDsFL_____		molecular association, regulation; receptor desensitization, altered		NHERF(DISRUPTS)		4227	1	0	0		
EGFR	EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Protein kinase, TK; Protein kinase, tyrosine (receptor)	P00533	1956	EGFR	7p12	human	Y1069	PHOSPHORYLATION	448056	EDSFLQRySSDPTGA		protein degradation; molecular association, regulation; ubiquitination		Cbl(INDUCES)		14148614; 4843014; 5396	31	12	114		
MYST1	ACETYLTRANSFERASE; Acetyltransferase; EC 2.3.1.48	Q9H7Z6	84148	KAT8	16p11.2	human	K274	ACETYLATION	479461	AKLFLDHkTLYFDVE	MOZ_SAS	protein conformation; enzymatic activity, induced				25020053	2	1	9		
MgcRacGAP	GTPase activating protein, Rac/Rho	Q9H0H5	29127	RACGAP1	12q13.12	human	S387	PHOSPHORYLATION	449096	ETGLYRIsGCDRTVK	DUF547; RhoGAP	activity, induced	cell cycle regulation; cell growth, altered			10425109; 2133	2	0	0	regulates cytokinesis; overexpression of the S387D mutant enhances the colony-forming ability of the v-Src-transformed cells  	
GGA1	Adaptor/scaffold; Vesicle protein	Q9UJY5	26088	GGA1	22q13.31	human	T270	PHOSPHORYLATION	2907511	LFRLASDtEDNDEAL	Ferritin; GAT	intracellular localization				8527	1	2	12		
p70S6K	EC 2.7.11.-; EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor); Translation	P67999	83840	Rps6kb1		rat	S452	PHOSPHORYLATION	471897	PVSPVKFsPGDFWGR		enzymatic activity, induced				5011214	1	10	51	Quadruple mutant was 20% protected  from inactivation by glucocorticoids. 	
NKCC1	Membrane protein, integral; Membrane protein, multi-pass; Transporter	P55011	6558	SLC12A2	5q23.3	human	T207	PHOSPHORYLATION	467236	YYDTHTNtYYLRTFG	AA_permease_N	activity, induced				8161	5	0	0		
Jun	Transcription factor	P05627	16476	Jun		mouse	S73	PHOSPHORYLATION	447943	VGLLKLAsPELERLI	Jun	activity, induced; sumoylation	apoptosis, induced; cell motility, altered; transcription, induced; transcription, altered; cell growth, altered			2429105; 4504; 2531304; 4914018; 4843007; 4843005	64	34	16		
SHIP-2	Carbohydrate Metabolism - inositol phosphate; EC 3.1.3.86; EC 3.1.3.n1; Motility/polarity/chemotaxis; Phosphatase, lipid	O15357	3636	INPPL1	11q13	human	T958	PHOSPHORYLATION	475076	APREEPLtPRLKPEG		phosphorylation				9295	1	1	1	Tyrosine phosphorylation is regulated by T958.	
BACH2	DNA binding protein; Transcription factor	Q9BYV9	60468	BACH2	6q15	human	S521	PHOSPHORYLATION	470117	ETRTRTSsSCSSYSY		intracellular localization	apoptosis, inhibited; transcription, altered; cell growth, altered			9002	1	0	0	regulates transcription of HO-1	
LTA4H	EC 3.3.2.6; Hydrolase; Lipid Metabolism - arachidonic acid	P09960	4048	LTA4H	12q22	human	S416	PHOSPHORYLATION	451021	KAYVEKFsYKSITTD		enzymatic activity, inhibited				3274	1	0	0	This phosphorylation and consequent enzymatic activity inhibition have not been observed in lung carcinoma cell line 	
FLT3	EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Protein kinase, TK; Protein kinase, tyrosine (receptor)	P36888	2322	FLT3	13q12	human	Y955	PHOSPHORYLATION	454873	ADAEEAMyQNVDGRV		molecular association, regulation; phosphorylation	cell cycle regulation	Grb2(INDUCES)		1992301; 7910519	4	0	15	regulates cell proliferation; While none of the single mutations affected STAT-5 phosphotyrosine levels, 3 double mutations did:  Y591/726F, Y591/955F, Y589/591F (all three pairs have Y591F in common).	
SSTR2	GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR	P30874	6752	SSTR2	17q24	human	Y71	PHOSPHORYLATION	469597	VIYVILRyAKMKTIT	7tm_1	molecular association, regulation	apoptosis, induced	PIK3R1(INDUCES)		8288	1	0	0	complex with PIK3R1 dissociates in the presence of somatostatin	
TXA2-R	GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR	P30987	21390	Tbxa2r		mouse	T230	PHOSPHORYLATION	3061800	VYHTREAtQRPRDCE	7tm_1	receptor desensitization, altered				8538	1	0	0	GRK2 mediated but not PKC 	
ANTXR2	Membrane protein, integral; Receptor, misc.	P58335	118429	ANTXR2	4q21.21	human	Y445	PHOSPHORYLATION	13320001	QPPQTKWyTPIKGRL	Ant_C	ubiquitination				13270511	1	0	0		
HER3	EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Protein kinase, TK; Protein kinase, tyrosine (receptor)	Q62799	29496	Erbb3		rat	Y1194	PHOSPHORYLATION	448640	EEDEDEEyEYMNRKR		molecular association, regulation; phosphorylation		PIK3CB(INDUCES); PIK3R1(INDUCES)		1836	5	1	23	induces phosphorylation of Akt1.	
NEK2	EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor)	P51955	4751	NEK2	1q32.2-q41	human	S241	PHOSPHORYLATION	12574600	RRIPYRYsDELNEII	Pkinase	enzymatic activity, inhibited				12482404	1	1	0		
CTNND2	Actin binding protein; Motility/polarity/chemotaxis	O35927	18163	Ctnnd2		mouse	T454	PHOSPHORYLATION	480958	TGTFRTStAPSSPGV		molecular association, regulation	cytoskeletal reorganization	RGNEF(INDUCES)		1172832	1	2	0	regulates dendrite formation in hippocampal neurons;  interaction with CTNND2 prevents RGNEF from interacting with and activating RhoA.	
GPIbA	Cell adhesion; Cell surface; Membrane protein, integral	P07359	2811	GP1BA	17pter-p12	human	S625	PHOSPHORYLATION	450660	SIRYSGHsL______		molecular association, regulation		14-3-3 zeta(INDUCES)		3124; 13164200	4	1	0		
p53	Activator protein; DNA binding protein; Motility/polarity/chemotaxis; Nuclear receptor co-regulator; Transcription factor; Tumor suppressor	P04637	7157	TP53	17p13.1	human	K164	UBIQUITINATION	486296	VRAMAIYkQSQHMTE	P53	protein degradation; intracellular localization				12136	1	1	0		
cortactin	Actin binding protein; Cytoskeletal protein; Motility/polarity/chemotaxis	Q60598	13043	Cttn		mouse	S113	PHOSPHORYLATION	465664	SKLSKHCsQVDSVRG	HS1_rep	molecular association, regulation		ACTA1(DISRUPTS)		8077	1	8	6	co-sedimentation assays with f-actin	
STAT1	DNA binding protein; Transcription factor	P42224	6772	STAT1	2q32.2	human	S727	PHOSPHORYLATION	447753	TDNLLPMsPEEFDEV	STAT1_TAZ2bind	activity, induced; sumoylation; molecular association, regulation	apoptosis, induced; apoptosis, inhibited; transcription, induced; transcription, altered; cell growth, altered	PIAS1(INDUCES); BRCA1(INDUCES)		20726803; 4805; 5745; 5820; 2714; 794; 5969; 4722; 3411; 6909; 2422208; 2415902; 5309424; 5957	79	9	82	induced by IFN-gamma	
Lasp-1	Actin binding protein; Motility/polarity/chemotaxis	O77506	100009568	LASP1		rabbit	S146	PHOSPHORYLATION	448836	AEPERRDsQDSSNYR		intracellular localization	cytoskeletal reorganization			3106	3	13	108		
MOR-1	GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR	P33535	25601	Oprm1		rat	T180	PHOSPHORYLATION	448127	VKALDFRtPRNAKIV	7tm_1	receptor desensitization, altered		MOR-1(NOT_REPORTED)		3365; 1679	3	0	0	Mutagenesis indicates T180 is required for receptor uncoupling, but phosphorylation of site has not been directly demonstrated.	
EPB41 iso2	Cytoskeletal protein	P11171-2	2035	EPB41	1p33-p32	human	T60	PHOSPHORYLATION	467259	LKASNGDtPTHEDLT		molecular association, regulation; intracellular localization	cell cycle regulation	NuMA-1(INDUCES); TUBA4A(INDUCES)		8208	1	2	1	Also associates  with tubulin and NuMA in vivo. Mutant EPB41 T60A-S679A abolishes localization to the mitotic spindle. 	
RCC1	Guanine nucleotide exchange factor, Ras	P18754	1104	RCC1	1p36.1	human	T32	PHOSPHORYLATION	2850001	VSHRSHStEPGLVLT		molecular association, regulation		KPNA4(DISRUPTS)		2831773	1	0	0		
GATA4	Motility/polarity/chemotaxis; Transcription factor	P43694	2626	GATA4	8p23.1-p22	human	S262	PHOSPHORYLATION	450013	IKPQRRLsASRRVGL		activity, induced	transcription, induced			6725	6	1	1		
RBX1	EC 6.3.2.-; Ligase; UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase	P62877	9978	RBX1	22q13.2	human	Y106	PHOSPHORYLATION	25180501	REWEFQKyGH_____		intracellular localization				25082853	1	0	0		
PKCB	EC 2.7.11.13; KINASE; Kinase, protein; Motility/polarity/chemotaxis; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor)	P04410	25023	Prkcb		rat	T642	PHOSPHORYLATION	447897	TRQPVELtPTDKLFI	Pkinase_C	intracellular localization; protein conformation; enzymatic activity, induced	transcription, altered			9069; 25785427; 1727	18	28	43	increases expression of c-Fos and c-Jun	
DAB2	Adaptor/scaffold	P98082	1601	DAB2	5p13	human	S24	PHOSPHORYLATION	451211	QAAPKAPsKKEKKKG		molecular association, regulation; intracellular localization	transcription, altered	ITGB3(INDUCES)		3973; 4231	4	0	0	N terminius of DAB2 negatively regulated TPA-induced AP-1 activity. 	
CLEC12B	Membrane protein, integral; Receptor, misc.	Q2HXU8	387837	CLEC12B	12p13.2	human	Y7	PHOSPHORYLATION	12518700	_MSEEVTyATLTFQD		molecular association, regulation; activity, inhibited		SHP-2(INDUCES); SHP-1(INDUCES)		12482410	1	0	0	inhibition of NK cell cytotoxicity	
Rb-like 2	Transcription, coactivator/corepressor	Q08999	5934	RBL2	16q12.2	human	T401	PHOSPHORYLATION	449723	SKALRIStPLTGVRY		molecular association, regulation	cell cycle regulation	E2F4(DISRUPTS)		1200; 5981	2	4	23		
p53	Activator protein; DNA binding protein; Motility/polarity/chemotaxis; Nuclear receptor co-regulator; Transcription factor; Tumor suppressor	P02340	22059	Tp53		mouse	S372	PHOSPHORYLATION	447534	TKKGQSTsRHKKTMV		acetylation				8707	14	1	0	S375D  mutant (S378 in human)  abrogates constitutive acetylation of p53 at K379 (K382 in human) and does not have any effect on acetylation of K370 (K373 in human) ;  
S375A (S378 in human) mutant stimulates p53 acetylation at K370 (K373 in human)	
PKCB iso2	EC 2.7.11.13; KINASE; Kinase, protein; Motility/polarity/chemotaxis; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor)	P05771-2	5579	PRKCB	16p11.2	human	S660	PHOSPHORYLATION	448672	QSEFEGFsFVNSEFL	Pkinase_C	intracellular localization				8740	14	21	140		
RPS19	Ribosomal protein; Translation	P17074		Rps19		rat	S59	PHOSPHORYLATION	7113803	WFYTRAAsTARHLYL	AFG1_ATPase; Ribosomal_S19e	molecular association, regulation		RPS19BP1(INDUCES)		6829230	1	0	0		
phosducin	G protein regulator, misc.	P20942	25343	Pdc		rat	S36	PHOSPHORYLATION	10431702	WRKFKLEsEDGDSIP	Phosducin	molecular association, regulation		GNB1(DISRUPTS); G-gamma(2)(DISRUPTS)		10144212	1	0	1		
FLT3	EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Protein kinase, TK; Protein kinase, tyrosine (receptor)	P36888	2322	FLT3	13q12	human	Y726	PHOSPHORYLATION	448644	KEHNFSFyPTFQSHP	Pkinase_Tyr	phosphorylation				1992301	2	1	5	While none of the single mutations affected STAT-5 phosphotyrosine levels, 3 double mutations did:  Y591/726F, Y591/955F, Y589/591F (all three pairs have Y591F in common).	
HES1	Cell development/differentiation; Motility/polarity/chemotaxis; Transcription factor	Q14469	3280	HES1	3q28-q29	human	S37	PHOSPHORYLATION	11424700	TASEHRKsSKPIMEK	HLH	molecular association, regulation	cytoskeletal reorganization; transcription, altered		DNA(DISRUPTS)	10274610	1	0	0	in vivo neurite outgrowth	
SHIP-2	Carbohydrate Metabolism - inositol phosphate; EC 3.1.3.86; EC 3.1.3.n1; Motility/polarity/chemotaxis; Phosphatase, lipid	O15357	3636	INPPL1	11q13	human	S132	PHOSPHORYLATION	468749	PPDDRDAsDGEDEKP		intracellular localization				26349419	2	12	0	Phosphorylated SHIP2 is localized in the nucleus and in nuclear speckles.  	
p70S6K	EC 2.7.11.-; EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor); Translation	P23443	6198	RPS6KB1	17q23.1	human	S447	PHOSPHORYLATION	448357	GSPRTPVsPVKFSPG		molecular association, regulation; enzymatic activity, induced	cell cycle regulation; cell adhesion, altered	tau iso8(NOT_REPORTED)		2563; 4719; 4805; 4759; 5631; 7444	90	23	211		
SIAH2	EC 6.3.2.-; EC 6.3.2.19; Ligase; Transcription, coactivator/corepressor; UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase	O43255	6478	SIAH2	3q25	human	S68	PHOSPHORYLATION	5393502	GGGAGPVsPQHHELT		protein degradation; molecular association, regulation; intracellular localization; enzymatic activity, induced	cytoskeletal reorganization	HIPK2(DISRUPTS)		5354423; 26341714	4	1	0		
GTF2I	DNA binding protein; Transcription, coactivator/corepressor	P78347	2969	GTF2I	7q11.23	human	Y248	PHOSPHORYLATION	448250	EESEDPDyYQYNIQA		activity, induced; intracellular localization	transcription, induced; transcription, altered			14790320; 4667; 4416; 12482269	8	2	11		
FGFR2	EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Protein kinase, TK; Protein kinase, tyrosine (receptor)	P21802	2263	FGFR2	10q26	human	Y769	PHOSPHORYLATION	448113	TLTTNEEyLDLSQPL		molecular association, regulation; enzymatic activity, induced	cell growth, altered	PLCG1(INDUCES); FRS2(INDUCES)		4609	3	0	0		
HMGA1	DNA binding protein	P17096	3159	HMGA1	6p21	human	T78	PHOSPHORYLATION	451516	KTRKTTTtPGRKPRG		molecular association, regulation			DNA(INDUCES)	970060	4	6	1	Cdc2 phosphorylated HMGA1 has lower binding affinity than  HIPK2 phosphorylated HMGA1. 	
ERK3	EC 2.7.11.24; KINASE; Kinase, protein; Protein kinase, CMGC; Protein kinase, Ser/Thr (non-receptor)	Q16659	5597	MAPK6	15q21	human	S688	PHOSPHORYLATION	13830503	QFHSPVGsPLKSIQA		protein stabilization				13326314	1	3	0		
HOXB7	DNA binding protein; Motility/polarity/chemotaxis; Transcription factor	P09629	3217	HOXB7	17q21.3	human	S133	PHOSPHORYLATION	465570	IYPWMRSsGTDRKRG			cell differentiation, altered			8028	1	0	0		
PKCD	EC 2.7.10.2; EC 2.7.11.13; KINASE; Kinase, protein; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor)	P09215	170538	Prkcd		rat	Y311	PHOSPHORYLATION	447573	TPETVGIyQGFEKKT		protein degradation; enzymatic activity, induced	apoptosis, induced			4313625; 6277000; 6901; 7309810; 3077; 1170	28	37	1723		
KPNA2	Karyopherin; Nuclear import; Nucleoporin	P52292	3838	KPNA2	17q24.2	human	K22	ACETYLATION	458963	HRFKNKGkDSTEMRR	IBB	activity, induced; molecular association, regulation; intracellular localization		HuR(INDUCES)		7490; 4180	3	0	0	promotes the nuclear localization of HuR; increases interaction with importin-beta in vitro	
DUOX1	EC 1.11.1.-; EC 1.6.3.1; Membrane protein, integral; Membrane protein, multi-pass; Oxidoreductase	Q9NRD9	53905	DUOX1	15q15.3	human	S955	PHOSPHORYLATION	6370301	KDLCRRAsYISQDMI		enzymatic activity, induced				6331313	1	1	0		
nNOS	Amino Acid Metabolism - arginine and proline; EC 1.14.13.39; Oxidoreductase	P29475	4842	NOS1	12q24.2-q24.31	human	Y609	PHOSPHORYLATION	465469	DYCDNSRyNILEEVA	NO_synthase	molecular association, regulation; enzymatic activity, inhibited		Src(INDUCES)		8000	1	0	0	prevents homodimerization	
coilin	Oxidoreductase	P38432	8161	COIL	17q22	human	S184	PHOSPHORYLATION	11329300	NEEAKRKsPKKKEKC		intracellular localization				10292908	2	1	0	S184A mutant localized to nucleolus	
TOB1	Adaptor/scaffold; Cell cycle regulation	P50616	10140	TOB1	17q21	human	S154	PHOSPHORYLATION	455536	SSVSSSPsPPFGHSA		activity, inhibited	cell cycle regulation; cell growth, altered			5435; 5416	3	0	0	the antiproliferative activity of TOB1 is inhibited by phosphorylation.; the antiproliferative function of TOB1 is inhibited by phosphorylation.	
FOXL2	DNA binding protein; Transcription factor	P58012	668	FOXL2	3q23	human	S326	PHOSPHORYLATION	21697905	PGQLSPAsPATAAPP		intracellular localization				21683740	1	1	0		
GLT1	Membrane protein, integral; Membrane protein, multi-pass; Transporter	P31596	29482	Slc1a2		rat	S113	PHOSPHORYLATION	450073	SGLDAKAsGRLGTRA	SDF	activity, induced				2648	1	0	0		
PLB	Inhibitor protein; Membrane protein, integral	P26678	5350	PLN	6q22.1	human	S16	PHOSPHORYLATION	448114	RSAIRRAsTIEMPQQ	Phospholamban; Baculo_11_kDa; BatA	activity, induced; molecular association, regulation; protein conformation		SERCA2(DISRUPTS); ATP2A1(DISRUPTS)		5347; 6115902; 5121512	39	8	56		
FOXO1A	DNA binding protein; Nuclear receptor co-regulator; Transcription factor	Q12778	2308	FOXO1	13q14.1	human	K245	ACETYLATION	459030	MLNPEGGkSGKSPRR	Fork_head	intracellular localization; phosphorylation				15022750	5	0	0		
Mpl	Membrane protein, integral; Receptor, cytokine	Q08351	17480	Mpl		mouse	S522	PHOSPHORYLATION	3091402	LRHALWPsLPDLHRV		activity, induced; phosphorylation	cell growth, altered			8388	1	0	0	tyrosine phosphorylation of JAK2	
SSRP1	Transcription initiation complex; Transcription, coactivator/corepressor	Q08945	6749	SSRP1	11q12	human	S510	PHOSPHORYLATION	455268	SSSNEGDsDRDEKKR		activity, inhibited	transcription, altered			4408	1	0	0		
EZH2	EC 2.1.1.43; METHYLTRANSFERASE; Methyltransferase; Methyltransferase, protein lysine; Oncoprotein	Q61188	14056	Ezh2		mouse	T345	PHOSPHORYLATION	4957354	LTAERIKtPPKRPGG		molecular association, regulation			RNA(INDUCES)	17675001	4	4	2	enhances interaction with HOTAIR noncoding RNA (ncRNA0	
H3	DNA binding protein	Q6LED0	291159	Hist1h2ail		rat	K15	ACETYLATION	458954	ARKSTGGkAPRKQLA			chromatin organization, altered; transcription, induced			12261	111	8	339		
ETV1	DNA binding protein; Transcription factor	P50549	2115	ETV1	7p21.3	human	S216	PHOSPHORYLATION	3059600	PMYQRQMsEPNIPFP	ETS_PEA3_N	activity, induced	transcription, induced			8495	3	1	1		
UGT2B7	Carbohydrate Metabolism - ascorbate and aldarate; Carbohydrate Metabolism - pentose and glucuronate interconversions; Carbohydrate Metabolism - starch and sucrose; Cofactor and Vitamin Metabolism - porphyrin and chlorophyll; Cofactor and Vitamin Metabolism - retinol; EC 2.4.1.17; Lipid Metabolism - androgen and estrogen; Membrane protein, integral; Transferase; Xenobiotic Metabolism - drug metabolism - cytochrome P450; Xenobiotic Metabolism - drug metabolism - other enzymes; Xenobiotic Metabolism - metabolism by cytochrome P450	P16662	7364	UGT2B7	4q13	human	Y438	PHOSPHORYLATION	7378201	RVINDPSyKENVMKL	UDPGT	enzymatic activity, induced				17431504; 7324313	2	1	0		
IRAK1BP1	Transcription regulation	Q9ESJ7	65099	Irak1bp1		mouse	S234	PHOSPHORYLATION	12524610	TVQQKIKsATIHAAS	SIMPL	intracellular localization	transcription, altered			12482402	1	0	0	nuclear localization	
IRAK1	EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, Ser/Thr (non-receptor); Protein kinase, TKL	P51617	3654	IRAK1	Xq28	human	T100	PHOSPHORYLATION	447720	LRARDIItAWHPPAP	Death		transcription, inhibited			1324	1	0	0		
FLNA	Actin binding protein; Motility/polarity/chemotaxis; Nuclear receptor co-regulator	P21333	2316	FLNA	Xq28	human	S2523	PHOSPHORYLATION	448843	VTGPRLVsNHSLHET		intracellular localization	cytoskeletal reorganization			2014	2	3	0		
SSRP1	Transcription initiation complex; Transcription, coactivator/corepressor	Q08945	6749	SSRP1	11q12	human	S688	PHOSPHORYLATION	456296	KRRRSEDsEEEELAS		activity, inhibited	transcription, altered			4408	1	0	0		
PARP1	DNA repair; EC 2.4.2.30; Nuclear envelope; Nuclear receptor co-regulator; Transferase	P09874	142	PARP1	1q41-q42	human	S372	PHOSPHORYLATION	463804	VAATPPPsTASAPAA		enzymatic activity, induced				7837	1	2	1		
Nur77	Apoptosis; DNA binding protein; Nuclear receptor	P12813	15370	Nr4a1		mouse	S142	PHOSPHORYLATION	2591500	GSPCSAPsPSTPNFQ		intracellular localization	transcription, altered			8679	3	0	0		
PIAS2	EC 6.3.2.-; Nuclear receptor co-regulator; SUMO LIGASE; SUMO conjugating system; Transcription, coactivator/corepressor	Q6AZ28	83422	Pias2		rat	S116	PHOSPHORYLATION	464654	IAPHSPSsPVASVLL			transcription, altered			7899	1	0	0	important for Elk1-mediated transcriptional activation 	
StAR	Carrier protein; Lipid binding protein; Mitochondrial	P70114		STAR		hamster	S55	PHOSPHORYLATION	450439	ISQVRRRsSLLGSQL		enzymatic activity, induced				8830	3	1	0		
ACC1	Carbohydrate Metabolism - propanoate; Carbohydrate Metabolism - pyruvate; EC 6.3.4.14; EC 6.4.1.2; Ligase; Lipid Metabolism - fatty acid biosynthesis	Q13085	31	ACACA	17q21	human	S80	PHOSPHORYLATION	448292	LHIRSSMsGLHLVKQ		intracellular localization				22726506	90	34	10	AMPKA1 activators increased phosphorylation level and cytoplasmic localization (reduced nuclear/cytoplasmic ratio). AMPKA1 activators reduced RNA synthesis in the nucleoli.	
PKD1	Autophagy; EC 2.7.11.13; KINASE; Kinase, protein; Motility/polarity/chemotaxis; Protein kinase, CAMK; Protein kinase, Ser/Thr (non-receptor)	Q62101	18760	Prkd1		mouse	S403	PHOSPHORYLATION	4169976	EDSNRTIsPSTSNNI		enzymatic activity, inhibited				7303911	1	14	3	in vitro	
CRMP-1	Cell development/differentiation; Cytoskeletal protein; Hydrolase	Q14194	1400	CRMP1	4p16.1	human	T102	PHOSPHORYLATION	11539301	AALVGGTtMIIDHVV	Amidohydro_1		cell cycle regulation			11484413	1	1	0		
STLK3	EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, STE; Protein kinase, Ser/Thr (non-receptor)	Q9Z1W9	53416	Stk39		mouse	T247	PHOSPHORYLATION	458885	VRKTFVGtPCWMAPE	Pkinase	enzymatic activity, induced				7457	1	1	11		
DUSP8	EC 3.1.3.16; EC 3.1.3.48; Motility/polarity/chemotaxis; Protein phosphatase, dual-specificity	O09112	18218	Dusp8		mouse	S520	PHOSPHORYLATION	22598804	LDSPGTPsPDGPWCF		enzymatic activity, inhibited	signaling pathway regulation			22495309	1	1	0	activates JNK pathway	
catalase	Amino Acid Metabolism - tryptophan; Apoptosis; EC 1.11.1.6; Endoplasmic reticulum; Energy Metabolism - methane; Hydrolase; Mitochondrial; Oxidoreductase	P24270	12359	Cat		mouse	Y386	PHOSPHORYLATION	450445	YRARVANyQRDGPMC	Catalase	protein degradation; enzymatic activity, induced				3035	2	0	0		
MAP2 iso3	Cytoskeletal protein; Motility/polarity/chemotaxis	P11137-3	4133	MAP2	2q34-q35	human	Y67	PHOSPHORYLATION	454429	EHGSQGTySNTKENG			cytoskeletal reorganization			7003	2	0	0	Mutations  Y50F, and Y267F did not alter the number of processes/cell but did increase the length of processes. 	
LRP1	Cell surface; Membrane protein, integral; Motility/polarity/chemotaxis; Receptor, misc.	G3V928	299858	Lrp1		rat	Y4474	PHOSPHORYLATION	473712	VEIGNPTyKMYEGGE		molecular association, regulation		CSK(INDUCES); PLCB1(INDUCES); SNX17(DISRUPTS); PIK3R1(INDUCES); Grb2(INDUCES)		10425107	3	2	2		
ERK3	EC 2.7.11.24; KINASE; Kinase, protein; Protein kinase, CMGC; Protein kinase, Ser/Thr (non-receptor)	Q16659	5597	MAPK6	15q21	human	S684	PHOSPHORYLATION	13830500	IGIPQFHsPVGSPLK		protein stabilization				13326314	1	3	0		
Src	EC 2.7.10.2; KINASE; Kinase, protein; Protein kinase, TK; Protein kinase, tyrosine (non-receptor)	P05480	20779	Src		mouse	Y424	PHOSPHORYLATION	448234	RLIEDNEyTARQGAK	Pkinase_Tyr	activity, induced; molecular association, regulation; enzymatic activity, induced	cell differentiation, altered; cytoskeletal reorganization	Grb2(INDUCES)		15031343; 6475; 5178; 5860	267	61	3059	represses osteoblast differentiation; required for normal organization of actin cytoskeleton and for bone resorption. 	
Dok7	Activator protein; Adaptor/scaffold	Q18PE0	231134	Dok7		mouse	Y406	PHOSPHORYLATION	17535700	PTSLRHHyDTPRSLR		molecular association, regulation; phosphorylation		Nck2(INDUCES); Crk(INDUCES); Nck1(INDUCES); CrkL(INDUCES); MuSK(INDUCES)		17482903	1	1	3	 plays an important role in AChR clustering; stimulates MuSK and AChR phosphorylation	
CEACAM1	Cell adhesion; Immunoglobulin superfamily; Membrane protein, integral; Motility/polarity/chemotaxis	P13688	634	CEACAM1	19q13.2	human	S461	PHOSPHORYLATION	6311908	FGKTGRAsDQRDLTE	DUF2668; Form-deh_trans	activity, inhibited	apoptosis, altered			6277002	1	0	0	blocks formation of lumen	
RSK3	EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor); Translation	Q15349	6196	RPS6KA2	6q27	human	S218	PHOSPHORYLATION	1883400	DHDKRAYsFCGTIEY	Pkinase	molecular association, regulation		AKAP6(DISRUPTS)		1883001	1	3	4	Presence of PDK1 kinase activity releases RSK3 from AKAP6.  A S218A RSK3 mutant interacts with AKAP6 in the presence or absence of PDK1 kinase activity.	
Bid	Apoptosis; Mitochondrial	P70444	12122	Bid		mouse	S64	PHOSPHORYLATION	448405	QTDGSQAsRSFNQGR	BID	protein stabilization	apoptosis, inhibited			1368	2	0	0	The double mutant S61A/S64A was used in this study	
IKKB	EC 2.7.11.10; KINASE; Kinase, protein; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor)	O88351	16150	Ikbkb		mouse	S701	PHOSPHORYLATION	17934904	ACDSLPEsDKKSEEL		molecular association, regulation; phosphorylation		PPP2R3C(INDUCES)		17675011	1	0	0	interaction with PPP2R3C (aka G4-1) downregulates IKK-beta activity;  S181 phosphorylation increased in S679/682/689/692/697/701/705A mutant	
CITED1	Nuclear receptor co-regulator	P97769	12705	Cited1		mouse	S64	PHOSPHORYLATION	3245861	ANGVPTSsSGSTSPI	CITED	intracellular localization	cell differentiation, induced			27780046	1	0	0	S63/64/65/67/69/73/79/80/84A mutation in CITED1 inhibits its translocation into the nucleus and osteoblasts differentiation	
osteopontin	Secreted; Secreted, signal peptide	P10451	6696	SPP1	4q22.1	human	S126	PHOSPHORYLATION	455739	QSDESHHsDESDELV	Osteopontin	molecular association, regulation; activity, inhibited			Other(INDUCES)	10425106	1	4	0	peptide with phosphorylated S117, S120, S123, S126 and S129 has increased binding to hydroxyapatite, and inhibits bone mineralization in vivo and in vitro 	
PKR	EC 2.7.10.2; EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor); Translation	P19525	5610	EIF2AK2	2p22-p21	human	S242	PHOSPHORYLATION	448085	NQRKAKRsLAPRFDL		enzymatic activity, induced				9075	2	1	0		
TOP2A	EC 5.99.1.3; Isomerase	P11388	7153	TOP2A	17q21-q22	human	S1525	PHOSPHORYLATION	448764	PIKYLEEsDEDDLF_		molecular association, regulation; intracellular localization; enzymatic activity, induced	cell cycle regulation; chromatin organization, altered; apoptosis, induced	MDC1(INDUCES)		5930040; 2425238	4	17	10	required for the decatenation checkpoint; required for normal sister chromatid segregationi late mitosis	
TWIST1	Cell development/differentiation; DNA binding protein; Inhibitor protein; Transcription regulation	Q15672	7291	TWIST1	7p21.2	human	S42	PHOSPHORYLATION	14821304	GGRKRRSsRRSAGGG			carcinogenesis, induced; apoptosis, altered			14780534	1	1	0		
Smad7	DNA binding protein; Transcription factor	O15105	4092	SMAD7	18q21.1	human	T96	PHOSPHORYLATION	15613800	EADLKALtHSVLKKL	MH1	molecular association, regulation	signaling pathway regulation	TGFBR1(DISRUPTS)		15331010	1	0	0	regulates TGFB1 signaling	
RARA	DNA binding protein; Nuclear receptor; Transcription factor	P10276	5914	RARA	17q21	human	S96	PHOSPHORYLATION	465508	FVCQDKSsGYHYGVS	zf-C4	activity, inhibited	transcription, inhibited			7957	1	0	0		
FOXO1A	DNA binding protein; Nuclear receptor co-regulator; Transcription factor	Q12778	2308	FOXO1	13q14.1	human	T402	PHOSPHORYLATION	12607400	PGTMMQQtPCYSFAP		intracellular localization	transcription, altered			12525214	1	0	0	multiple site mutant (8A)	
USP1	EC 3.1.2.15; EC 3.4.19.12; Protease; Ubiquitin conjugating system; Ubiquitin-specific protease	O94782	7398	USP1	1p31.3	human	S313	PHOSPHORYLATION	3177796	ATSDTLEsPPKIIPK	UCH	enzymatic activity, induced		WDR48(INDUCES)		27258205	1	5	6		
TORC2	Transcription, coactivator/corepressor	Q8BH09	74343	Crtc2		mouse	K628	UBIQUITINATION	487505	DSSPGFSkEIAAALA	TORC_C	protein degradation				12291	1	0	0		
KCNJ8	Channel, potassium; Membrane protein, integral; Membrane protein, multi-pass	Q63664	25472	Kcnj8		rat	S391	PHOSPHORYLATION	1458602	NSMRRNNsMRRSNSI		activity, inhibited				1172871	1	0	0		
Fos	DNA binding protein; Motility/polarity/chemotaxis; Transcription factor	P01100	2353	FOS	14q24.3	human	S308	PHOSPHORYLATION	7388000	ADWEPLHsGSLGMGP		protein stabilization				7303915	1	0	0		
14-3-3 beta	Adaptor/scaffold	P35213	56011	Ywhab		rat	S65	PHOSPHORYLATION	467269	RSSWRVIsSIEQKTE	14-3-3; BLOC1_2; FliM; DUF4303	intracellular localization	transcription, altered			8213	1	0	0	Double mutant inhibited a MEF2 reporter and promotes nuclear localization  of HDAC4/GFP.	
GSK3A	EC 2.7.11.1; EC 2.7.11.26; KINASE; Kinase, protein; Protein kinase, CMGC; Protein kinase, Ser/Thr (non-receptor)	P49840	2931	GSK3A	19q13.2	human	Y279	PHOSPHORYLATION	447723	RGEPNVSyICSRYYR	Pkinase	enzymatic activity, induced	apoptosis, altered			6011119	16	72	4190		
SSB	Transcription initiation complex	P05455	6741	SSB	2q31.1	human	S366	PHOSPHORYLATION	449301	GKKTKFAsDDEHDEH		activity, induced; activity, inhibited	transcription, induced; transcription, inhibited			2170; 27519615; 8608; 2865432	9	33	116	inhibits recycling of RNA pol III complexes; S366A mutant had reduced viral gene expression.	
PKCZ	EC 2.7.11.13; KINASE; Kinase, protein; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor)	Q05513	5590	PRKCZ	1p36.33-p36.2	human	T410	PHOSPHORYLATION	447510	GPGDTTStFCGTPNY	Pkinase	molecular association, regulation; protein conformation; enzymatic activity, induced	cytoskeletal reorganization	TNNI1(INDUCES); desmin(INDUCES); TPM1(INDUCES); MYO1C(INDUCES); TNNT1(INDUCES)		1243600; 2195496; 6690; 5121505; 4001; 5285; 11758; 4726; 14058625	41	4	8		
IRS2	Adaptor/scaffold; Motility/polarity/chemotaxis	P81122	384783	Irs2		mouse	S573	PHOSPHORYLATION	483923	GLRKRTYsLTTPARQ		molecular association, regulation		14-3-3 beta(INDUCES)		25712647	1	17	9		
iNOS	Amino Acid Metabolism - arginine and proline; EC 1.14.13.39; Oxidoreductase	P35228	4843	NOS2	17q11.2-q12	human	Y1055	PHOSPHORYLATION	4115776	LPGKPKVyVQDILRQ	NAD_binding_1	protein stabilization				11189925	1	2	4		
ER-alpha	DNA binding protein; Nuclear receptor	P03372	2099	ESR1	6q25.1	human	S104	PHOSPHORYLATION	448099	FPPLNSVsPSPLMLL	Oest_recep	activity, induced; molecular association, regulation	transcription, induced; transcription, altered	NCoA2(INDUCES); Src(INDUCES); SRC-3(INDUCES); CBP(INDUCES)		5400; 4888108; 6685; 4254812	19	1	0		
AML3	DNA binding protein; Transcription factor	Q13950	860	RUNX2	6p21	human	S294	PHOSPHORYLATION	10892804	DPRQAQSsPPWSYDQ			transcription, induced			10353940	6	0	0		
ER-beta	DNA binding protein; Nuclear receptor	O08537	13983	Esr2		mouse	S236	PHOSPHORYLATION	473056	VRRQRSAsEQVHCLN		intracellular localization				9166	2	0	0	S236 phosphorylation modulates intranuclear localization in Akt activated cells.	
PLCG1	Carbohydrate Metabolism - inositol phosphate; EC 3.1.4.11; Motility/polarity/chemotaxis; Phospholipase	P08487	281987	PLCG1		cow	Y775	PHOSPHORYLATION	448907	EPDYGALyEGRNPGF		enzymatic activity, induced	transcription, altered			5812	2	14	384	Mutation of Y775 or Y783 reduced PLCG1-mediated calcium mobilization and transcriptional activation	
CLK2	EC 2.7.12.1; KINASE; Kinase, protein; Protein kinase, CMGC; Protein kinase, dual-specificity	O35491	12748	Clk2		mouse	T343	PHOSPHORYLATION	26375903	HHSTIVStRHYRAPE	Pkinase	enzymatic activity, induced				25779410	1	0	0		
Rb	Nuclear receptor co-regulator; Transcription, coactivator/corepressor; Tumor suppressor	P13405	19645	Rb1		mouse	S781	PHOSPHORYLATION	450022	PIPHIPRsPYKFSSS	Rb_C	molecular association, regulation		E2F1(DISRUPTS)		1258	8	9	65		
DAB1	Adaptor/scaffold	P97318	13131	Dab1		mouse	Y200	PHOSPHORYLATION	447960	VEDPVYQyIVFEAGH			cytoskeletal reorganization			6498	4	0	0		
p57Kip2	Inhibitor protein; Nuclear receptor co-regulator	P49918	1028	CDKN1C	11p15.5	human	T310	PHOSPHORYLATION	450869	GVGSVEQtPRKRLR_		protein degradation; molecular association, regulation		SKP2(INDUCES)		27623409; 3030	3	0	2	DN-Akt stabilized p57	
RGS19	GTPase activating protein, RGS	P49795	10287	RGS19	20q13.33	human	S151	PHOSPHORYLATION	447873	EDYVSILsPKEVSLD	RGS	activity, induced				8517; 1104	2	0	0		
SLC5A5	Membrane protein, integral; Membrane protein, multi-pass; Transporter	Q63008	114613	Slc5a5		rat	T577	PHOSPHORYLATION	990308	APKEDTAtLEESLVK		activity, induced; protein stabilization				970026	1	1	0		
GRK1	EC 2.7.11.14; KINASE; Kinase, protein; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor)	P28327	281457	GRK1		cow	S5	PHOSPHORYLATION	2528801	___MDFGsLETVVAN		enzymatic activity, induced				2425228	1	1	0	in vitro	
CYP3A4	Cell surface; Cofactor and Vitamin Metabolism - retinol; EC 1.14.13.-; EC 1.14.13.32; EC 1.14.13.67; EC 1.14.13.97; EC 1.14.14.1; Lipid Metabolism - linoleic acid; Membrane protein, integral; Oxidoreductase; Xenobiotic Metabolism - drug metabolism - cytochrome P450; Xenobiotic Metabolism - drug metabolism - other enzymes; Xenobiotic Metabolism - metabolism by cytochrome P450	P08684	1576	CYP3A4	7q21.1	human	T264	PHOSPHORYLATION	5938005	KESRLEDtQKHRVDF	p450	protein degradation; ubiquitination				5930038; 22463923	2	2	0		
NRF2	DNA binding protein; Transcription factor	Q16236	4780	NFE2L2	2q31	human	S408	PHOSPHORYLATION	10292700	GDMVQPLsPSQGQST		intracellular localization	transcription, induced			9983602	1	1	0	moderate effects observed only in NFE2L2-5A mutant	
PELP1	Nuclear receptor co-regulator; Transcription, coactivator/corepressor	Q8IZL8	27043	PELP1	17p13.2	human	Y920	PHOSPHORYLATION	473548	EEEDEEEyFEEEEEE		molecular association, regulation	apoptosis, inhibited; cell growth, altered	PIK3R1(INDUCES)		9179	1	0	0		
KPNA2	Karyopherin; Nuclear import; Nucleoporin	P52292	3838	KPNA2	17q24.2	human	S105	PHOSPHORYLATION	454033	QAARKLLsREKQPPI		activity, induced; molecular association, regulation; intracellular localization		HuR(INDUCES)		4180	2	0	0	promotes the nuclear localization of HuR	
PDE4B	EC 3.1.4.17; Nucleotide Metabolism - purine; Phosphodiesterase	Q07343	5142	PDE4B	1p31	human	S133	PHOSPHORYLATION	449097	GHSQRREsFLYRSDS		enzymatic activity, induced				7471	2	8	0		
ORAI1	Channel, calcium; Membrane protein, integral; Membrane protein, multi-pass	Q96D31	84876	ORAI1	12q24.31	human	S27	PHOSPHORYLATION	469411	GGSTTSGsRRSRRRS		activity, inhibited				14780529	2	0	0		
MDM2	EC 6.3.2.-; EC 6.3.2.19; Inhibitor protein; Ligase; UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase	Q00987	4193	MDM2	12q14.3-q15	human	S157	PHOSPHORYLATION	455457	SHLVSRPsTSSRRRA		enzymatic activity, induced	cell cycle regulation; apoptosis, altered			5219	1	0	0	increases E3 ligase activity toward p53 and promotes p53 degradation	
CSF2RB	Membrane protein, integral; Receptor, cytokine	P32927	1439	CSF2RB	22q13.1	human	Y822	PHOSPHORYLATION	450124	VLQQVGDyCFLPGLG		activity, induced	apoptosis, altered; transcription, altered; cell growth, altered			2722; 8533	2	0	0		
p63	DNA binding protein; Transcription factor	Q9H3D4	8626	TP63	3q28	human	S560	PHOSPHORYLATION	4668108	LARLGCSsCLDYFTT	SAM_2	protein degradation				4659601	1	1	0		
PDGFRB	EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Protein kinase, TK; Protein kinase, tyrosine (receptor)	P09619	5159	PDGFRB	5q33.1	human	Y970	PHOSPHORYLATION	4833940	GEGYKKKyQQVDEEF		enzymatic activity, induced	cell motility, altered			7324304	1	2	0	in vitro	
PTEN	Carbohydrate Metabolism - inositol phosphate; EC 3.1.3.16; EC 3.1.3.48; EC 3.1.3.67; Motility/polarity/chemotaxis; Nuclear receptor co-regulator; PHOSPHATASE; Phosphatase, lipid; Tumor suppressor	O08586	19211	Pten		mouse	T366	PHOSPHORYLATION	449634	ASSSTSVtPDVSDNE		protein stabilization				15755106	4	2	0		
TRF1	DNA binding protein	P54274	7013	TERF1	8q21.11	human	T122	PHOSPHORYLATION	2481000	LTACQLRtIYICQFL	TRF	protein stabilization; molecular association, regulation; intracellular localization		TRF1(INDUCES); CK2-B(INDUCES)	DNA(INDUCES)	2425237	1	0	0	regulates telomere length 	
GluR1	Channel, calcium; Channel, ligand-gated; Membrane protein, integral; Membrane protein, multi-pass	P23818	14799	Gria1		mouse	S863	PHOSPHORYLATION	448566	TSTLPRNsGAGASGG		activity, induced; protein stabilization; receptor desensitization, altered; intracellular localization; receptor internalization, altered				1163201; 12068400; 11999211; 1985; 3361001	64	0	0	Phosphorylation sites required for synaptic plasticity.; required for hippocampal long term depression (LTD); synaptic plasticity; perisynaptic localizaation;  associative LTD requires phosphorylation of both S863 and S849.; Associative LTP requires S863 phosphorylation	
nNOS	Amino Acid Metabolism - arginine and proline; EC 1.14.13.39; Oxidoreductase	P29476	24598	Nos1		rat	T1296	PHOSPHORYLATION	457129	DHIYREEtLQAKNKG	NAD_binding_1	enzymatic activity, inhibited				7012	1	0	0		
CDX2	DNA binding protein; Transcription factor	P43241	12591	Cdx2		mouse	S60	PHOSPHORYLATION	460651	ANLDSAQsPGPSWPT	Caudal_act		transcription, inhibited			22343800; 7795	3	0	0	regulates cell differentiation	
CDK9	EC 2.7.11.22; EC 2.7.11.23; KINASE; Kinase, protein; Nuclear receptor co-regulator; Protein kinase, CMGC; Protein kinase, Ser/Thr (non-receptor)	P50750	1025	CDK9	9q34.1	human	S175	PHOSPHORYLATION	456536	FGLARAFsLAKNSQP	Pkinase	molecular association, regulation; enzymatic activity, inhibited; enzymatic activity, induced	transcription, altered	HEXIM1(DISRUPTS); CCNT1(INDUCES); BRD4(NOT_REPORTED)		6742; 18837502	3	1	0	CDK9 S175A mutant activates HIV-1 transcription; Mutation to A or D abrogates binding.  Mutation to D activates the kinase (S->A abolishes kinase activity).  The S->D mutation is defective as a transcription factor (due to no Brd4 binding which leads to less promoter binding and Mediator interactions).	
TRPV4	Channel, cation; Membrane protein, integral; Membrane protein, multi-pass	Q9EPK8	63873	Trpv4		mouse	S824	PHOSPHORYLATION	4777181	LRRDRWSsVVPRVVE		activity, induced; protein stabilization; molecular association, regulation; intracellular localization	apoptosis, inhibited		Other(INDUCES)	22495310	3	3	0	S824D mutant shows enhanced interaction with F-actin	
PGC-1 alpha	Nuclear receptor co-regulator; Transcription, coactivator/corepressor	Q9UBK2	10891	PPARGC1A	4p15.1	human	T299	PHOSPHORYLATION	448009	AGLTPPTtPPHKANQ		protein stabilization				1382	2	1	1		
NOLC1	Transcription, coactivator/corepressor	P41777	64896	Nolc1		rat	S113	PHOSPHORYLATION	455684	AAPAKRAsLPQHAGK		activity, induced	transcription, altered			6382	1	2	0		
CAMK2A	EC 2.7.11.17; KINASE; Kinase, protein; Protein kinase, CAMK; Protein kinase, Ser/Thr (non-receptor)	Q9UQM7	815	CAMK2A	5q32	human	T306	PHOSPHORYLATION	449596	LKGAILTtMLATRNF		intracellular localization				3249408	13	6	1		
EphA4	EC 2.7.1.112; EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Protein kinase, TK; Protein kinase, tyrosine (receptor)	P54764	2043	EPHA4	2q36.1	human	Y602	PHOSPHORYLATION	450857	TYVDPFTyEDPNQAV		molecular association, regulation		Fyn(INDUCES)		2852629	6	14	156		
4E-BP1	Translation; Translation initiation	Q62622	116636	Eif4ebp1		rat	S111	PHOSPHORYLATION	447526	KRAGGEEsQFEMDI_	eIF_4EBP	molecular association, regulation		eIF4E(DISRUPTS)		1637	5	3	15		
CITED1	Nuclear receptor co-regulator	P97769	12705	Cited1		mouse	S79	PHOSPHORYLATION	8112774	GSPTATPsSKPPSFN	CITED	intracellular localization	cell differentiation, induced			27780046	1	0	0	S63/64/65/67/69/73/79/80/84A mutation in CITED1 inhibits its translocation into the nucleus and osteoblasts differentiation	
RPLP2	Ribosomal protein; Translation	P02401	140662	Rplp2		rat	S105	PHOSPHORYLATION	454320	KKEESEEsDDDMGFG	Ribosomal_60s	activity, induced	translation, altered			8697	3	71	324		
cortactin	Actin binding protein; Cytoskeletal protein; Motility/polarity/chemotaxis	Q60598	13043	Cttn		mouse	Y334	PHOSPHORYLATION	450862	VVQVPSAyQKTVPIE	FadA		cell cycle regulation; cell motility, altered			2790302	2	14	273		
DLG1	Adaptor/scaffold; Motility/polarity/chemotaxis	Q62696	25252	Dlg1		rat	S39	PHOSPHORYLATION	451614	SSIERVIsIFQSNLF	L27_1	molecular association, regulation; intracellular localization		NMDAR2A(INDUCES)		9102; 3742	3	0	0	facilitates the release of SAP97 from the endoplasmic reticulum;  induces SAP97/NMDAR2A trafficking to the postsynaptic compartment	
DAB2	Adaptor/scaffold	O88797	79128	Dab2		rat	S24	PHOSPHORYLATION	451211	QAAPKAPsKKEKKKG		molecular association, regulation	transcription, altered	MIB1(INDUCES)		3441	4	0	0		
PTHR	GPCR, family 2; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR	P25961	56813	Pth1r		rat	S492	PHOSPHORYLATION	2853102	RKARSGSsSYSYGPM		receptor internalization, altered; activity, inhibited				8759; 2831777	2	0	1		
MCM4	DNA replication; EC 3.6.4.12	P33991	4173	MCM4	8q11.2	human	T110	PHOSPHORYLATION	450002	PRSGVRGtPVRQRPD		activity, inhibited				2551	2	9	7		
AR	DNA binding protein; Nuclear receptor; Transcription factor	P10275	367	AR	Xq12	human	S308	PHOSPHORYLATION	448413	TEDTAEYsPFKGGYT	Androgen_recep		transcription, altered			8049	7	2	0		
Tks5	Adaptor/scaffold	O89032	14218	Sh3pxd2a		mouse	S566	PHOSPHORYLATION	3199157	VPAFGFDsEPEMNEE			cell cycle regulation; cell motility, altered			2790302	0	7	15		
Gab1	Adaptor/scaffold; Motility/polarity/chemotaxis	Q9QYY0	14388	Gab1		mouse	Y407	PHOSPHORYLATION	447946	DASSQDCyDIPRTFP		molecular association, regulation	cell differentiation, altered; cell growth, altered	PLCG1(INDUCES)		1102	3	21	1074		
uPA	EC 3.4.21.73; Motility/polarity/chemotaxis; Protease; Secreted; Secreted, signal peptide	P00749	5328	PLAU	10q22.2	human	S323	PHOSPHORYLATION	451053	TGFGKENsTDYLYPE	Trypsin	molecular association, regulation; intracellular localization	cell motility, altered; cell adhesion, altered; cytoskeletal reorganization	ITGA5(INDUCES); ITGB5(INDUCES)		12482216; 5014006	3	0	0	reduces ITGB5/ITGA5 activation and its interaction with vitronectin and talin; ligand-dependent uPA redistribution severely impaired in a S158/323E mutant	
CTCF	C2H2-type zinc finger protein; Transcription factor	Q08705	396274	CTCF		chicken	S609	PHOSPHORYLATION	448303	MRSKKEDsSDSEENA			transcription, altered; cell growth, altered			1410	1	5	0		
EGFR	EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Protein kinase, TK; Protein kinase, tyrosine (receptor)	Q01279	13649	Egfr		mouse	Y270	PHOSPHORYLATION	457625	TCPPLMLyNPTTYQM	Furin-like	molecular association, regulation		EGFR(INDUCES)		7233	1	0	0		
LRP1	Cell surface; Membrane protein, integral; Motility/polarity/chemotaxis; Receptor, misc.	Q07954	4035	LRP1	12q13.3	human	S4523	PHOSPHORYLATION	7103863	GSRHSLAsTDEKREL		molecular association, regulation; receptor internalization, altered		Shc1(INDUCES); GULP1(INDUCES); DAB1(INDUCES)		12482284	1	9	0		
ADD2	Cytoskeletal protein; Motility/polarity/chemotaxis	P35612	119	ADD2	2p13.3	human	S726	PHOSPHORYLATION	449803	KKKEKVEs_______		protein degradation; intracellular localization	cytoskeletal reorganization			6705; 2346	2	0	0		
CAMK2A	EC 2.7.11.17; KINASE; Kinase, protein; Protein kinase, CAMK; Protein kinase, Ser/Thr (non-receptor)	P11798	12322	Camk2a		mouse	T305	PHOSPHORYLATION	448802	KLKGAILtTMLATRN		intracellular localization				1965	18	3	0		
ID2	DNA binding protein; Transcription, coactivator/corepressor	P41137	25587	Id2		rat	S5	PHOSPHORYLATION	451265	___MKAFsPVRSVRK		intracellular localization	cell cycle regulation; transcription, altered; cell growth, altered			3485	2	1	0		
WDR77	Adaptor/scaffold; Nuclear receptor co-regulator; Transcription, coactivator/corepressor	Q9BQA1	79084	WDR77	1p13.2	human	S264	PHOSPHORYLATION	17797201	CVTGLVFsPHSVPFL	WD40		carcinogenesis, altered			17722104	1	1	0	in CCND1 T286A mutant 	
IRF8	DNA binding protein; Transcription factor	Q02556	3394	IRF8	16q24.1	human	Y107	PHOSPHORYLATION	2299204	QLDISEPyKVYRIVP	IRF		transcription, inhibited			2195716	2	0	0	represses PTPN13 promoter activity	
DYRK1A	EC 2.7.12.1; EC 2.7.12.2; KINASE; Kinase, protein; Protein kinase, CMGC; Protein kinase, dual-specificity	Q63470	25255	Dyrk1a		rat	Y321	PHOSPHORYLATION	448553	LGQRIYQyIQSRFYR	Pkinase	enzymatic activity, induced				3536; 2064; 2852630	5	82	3664		
GLIS2	C2H2-type zinc finger protein	Q9BZE0	84662	GLIS2	16p13.3	human	S245	PHOSPHORYLATION	17790902	PTCSKSFsRLENLKI	zf-H2C2_2	molecular association, regulation; activity, inhibited	transcription, inhibited		DNA(DISRUPTS)	17675014	1	1	0		
Cdc34	EC 6.3.2.19; Ligase; UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase	P49427	997	CDC34	19p13.3	human	S222	PHOSPHORYLATION	448688	EVEEEADsCFGDDED		intracellular localization				1868	2	0	0		
P38A	EC 2.7.1.37; EC 2.7.11.24; KINASE; Kinase, protein; Protein kinase, CMGC; Protein kinase, Ser/Thr (non-receptor)	P47811	26416	Mapk14		mouse	Y323	PHOSPHORYLATION	455799	DEPVADPyDQSFESR		enzymatic activity, induced	cell cycle regulation			5354445; 7313808	5	0	0	 decreased IFN-gamma production in TCR-activated p38-alpha Y322F cells;  ; in vitro; proliferation of p38-alpha Y322F  T cells stimulated with anti-CD3/CD28, but not with PMA and ionomycin is delayed	
GIRK1	Channel, potassium; Membrane protein, integral; Membrane protein, multi-pass	P35562	16519	Kcnj3		mouse	Y12	PHOSPHORYLATION	457610	RRKFGDDyQVVTTSS		activity, inhibited				10353930	4	0	0	decreases channel conductance	
PKCT	EC 2.7.11.13; KINASE; Kinase, protein; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor)	Q04759	5588	PRKCQ	10p15	human	S676	PHOSPHORYLATION	447905	LNEKPRLsFADRALI	Pkinase_C	enzymatic activity, induced	transcription, altered			1630; 6963	5	7	6	inhibits transcription; assayed in vitro	
p70S6K	EC 2.7.11.-; EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor); Translation	P23443	6198	RPS6KB1	17q23.1	human	S441	PHOSPHORYLATION	450015	SPRRFIGsPRTPVSP		enzymatic activity, induced				2563	8	15	67		
AT1	GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR	P30556	185	AGTR1	3q24	human	T332	PHOSPHORYLATION	467239	KSHSNLStKMSTLSY		activity, induced; molecular association, regulation; intracellular localization; receptor internalization, altered		ARRB1(INDUCES); ARRB2(INDUCES)		8345; 8199	2	0	0		
CCDC6	Apoptosis; Cytoskeletal protein	Q16204	8030	CCDC6	10q21	human	S244	PHOSPHORYLATION	450707	QPVSAPPsPRDISME	DUF2046	activity, induced	apoptosis, induced			3075	3	53	38		
p53	Activator protein; DNA binding protein; Motility/polarity/chemotaxis; Nuclear receptor co-regulator; Transcription factor; Tumor suppressor	P04637	7157	TP53	17p13.1	human	T387	PHOSPHORYLATION	455224	HKKLMFKtEGPDSD_		activity, induced; molecular association, regulation	transcription, altered	14-3-3 epsilon(INDUCES); 14-3-3 gamma(INDUCES)		4400; 12300001; 4641429	4	0	0		
Bcl-10	Apoptosis; Transcription, coactivator/corepressor	Q9Z0H7	12042	Bcl10		mouse	S138	PHOSPHORYLATION	470125	NNLSRCNsDESNLSE		activity, induced; protein degradation				11753	7	11	18		
ERK5	EC 2.7.11.24; KINASE; Kinase, protein; Protein kinase, CMGC; Protein kinase, Ser/Thr (non-receptor)	Q13164	5598	MAPK7	17p11.2	human	S803	PHOSPHORYLATION	20572701	QREIQMDsPMLLADL		intracellular localization; enzymatic activity, inhibited	transcription, altered			19084403	1	2	0		
Ctip	EC 3.1.-.-; Transcription, coactivator/corepressor	Q99708	5932	RBBP8	18q11.2	human	S664	PHOSPHORYLATION	448391	IDPGADLsQYKMDVT		molecular association, regulation		BRCA1(DISRUPTS)		1047	1	0	0		
KIF2C	Cancer Testis Antigen (CTA); Microtubule binding protein; Motility/polarity/chemotaxis; Motor protein	Q99661	11004	KIF2C	1p34.1	human	S95	PHOSPHORYLATION	451107	IQKQKRRsVNSKIPA		molecular association, regulation; intracellular localization; activity, inhibited	cytoskeletal reorganization	EB1(DISRUPTS)		9985931; 3306	4	1	3	involved in microtubule tip tracking 	
RhoQ	G protein; G protein, monomeric, Rho; Motility/polarity/chemotaxis	Q8R527	104215	Rhoq		mouse	T189	PHOSPHORYLATION	5996401	ILTPKKHtVKKRIGS		intracellular localization	cytoskeletal reorganization			5930006	1	0	0		
CSFR	EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Protein kinase, TK; Protein kinase, tyrosine (receptor)	P09581	12978	Csf1r		mouse	Y544	PHOSPHORYLATION	2866400	KYKQKPKyQVRWKII		enzymatic activity, induced	cell differentiation, altered; cell growth, altered			4651302	5	0	0		
HER4	EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Protein kinase, TK; Protein kinase, tyrosine (receptor)	Q15303	2066	ERBB4	2q33.3-q34	human	Y1202	PHOSPHORYLATION	4825105	PPKAEDEyVNEPLYL		molecular association, regulation		Syk(INDUCES)		4651319	0	1	1		
RSK2	EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor)	P18654	110651	Rps6ka3		mouse	T577	PHOSPHORYLATION	450152	AENGLLMtPCYTANF	Pkinase	enzymatic activity, induced				1263	5	5	169		
Ikaros	C2H2-type zinc finger protein; DNA binding protein; Transcription factor	Q03267	22778	Ikzf1		mouse	S213	PHOSPHORYLATION	28735108	GRSYKQRsSLEEHKE		molecular association, regulation; intracellular localization	transcription, induced		DNA(INDUCES)	28722169	1	1	0	nuclear localization, ITGA4, MDM1, EIF4E3, KIF23, TNFAIP8L2 DNA binding/transcription  inhibited by BTK siRNA	
RasGRF1	Guanine nucleotide exchange factor, Ras	P28818	192213	Rasgrf1		rat	S731	PHOSPHORYLATION	469604	PLAIGTSsPVRRRKL	RasGEF_N	protein degradation				8268	1	2	1	causes nuclear disorganization in CHO cells	
KIF22	Microtubule binding protein; Motor protein	Q14807	3835	KIF22	16p11.2	human	T463	PHOSPHORYLATION	456110	QGAPLLStPKRERMV		intracellular localization		TUBA4A(DISRUPTS)		8594	2	5	22	Phosphorylation on T463 is required for chromosomal localization during mitosis and regulates association with microtubules.	
CACNA1B	Channel, calcium; Membrane protein, integral; Membrane protein, multi-pass	Q02294	257648	Cacna1b		rat	S896	PHOSPHORYLATION	455283	ERARPRRsHSKEAPG		activity, inhibited				8797	2	0	0	Phosphorylation by PKC prevents effects of syntaxin 1A on voltage dependent inactivation of N-type calcium channels. 	
CDK1	EC 2.7.11.22; EC 2.7.11.23; KINASE; Kinase, protein; Motility/polarity/chemotaxis; Protein kinase, CMGC; Protein kinase, Ser/Thr (non-receptor)	P06493	983	CDK1	10q21.1	human	Y4	PHOSPHORYLATION	473276	____MEDyTKIEKIG	Pkinase	protein degradation; ubiquitination	cell cycle regulation			13326325	1	2	4		
PERK	EC 2.7.11.1; KINASE; Kinase, protein; Membrane protein, integral; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor); Translation	Q9NZJ5	9451	EIF2AK3	2p12	human	T982	PHOSPHORYLATION	447936	MPAYARHtGQVGTKL	Pkinase	enzymatic activity, induced				3421	7	0	0		
claudin 16	Cell adhesion; Membrane protein, integral; Membrane protein, multi-pass	Q91Y55	155268	Cldn16		rat	S217	PHOSPHORYLATION	2872000	AGVSMAKsYKAPRTE		activity, induced; protein stabilization; intracellular localization				2865412	1	0	0		
MEF2A	DNA binding protein; Motility/polarity/chemotaxis; Transcription factor	Q02078	4205	MEF2A	15q26	human	T319	PHOSPHORYLATION	448098	TPVVSVTtPSLPPQG		activity, induced	transcription, altered			1159; 2504	2	0	0		
RhoA	G protein; G protein, monomeric, Rho; Motility/polarity/chemotaxis	Q9QUI0	11848	Rhoa		mouse	S188	PHOSPHORYLATION	449035	ARRGKKKsGCLIL__		activity, inhibited	transcription, altered; transcription, inhibited			5309412; 11554703	9	0	0		
PLD2	EC 3.1.4.4; Lipid Metabolism - ether lipid; Lipid Metabolism - glycerophospholipid; Motility/polarity/chemotaxis; Phospholipase	P97813	18806	Pld2		mouse	Y165	PHOSPHORYLATION	453411	HTASKQKyLENYLNR	PX	intracellular localization; phosphorylation; enzymatic activity, induced				4130	1	0	0		
p70S6K	EC 2.7.11.-; EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor); Translation	P67999	83840	Rps6kb1		rat	T412	PHOSPHORYLATION	448607	NQVFLGFtYVAPSVL	Pkinase_C	enzymatic activity, induced				5011215; 6548; 2670105; 6139; 5011214; 735	301	1	1	Quadruple mutant was 20% protected  from inactivation by glucocorticoids. ; Leads to increase in cell size.	
eIF2-beta	Translation; Translation initiation	P20042	8894	EIF2S2	20q11.2	human	S2	PHOSPHORYLATION	451805	______MsGDEMIFD			translation, altered; cell growth, altered			7655	4	22	0		
PML iso3	Transcription factor; Tumor suppressor; Ubiquitin conjugating system	P29590-3	5371	PML	15q22	human	S117	PHOSPHORYLATION	455494	ESLQRRLsVYRQIVD			apoptosis, induced			5335	1	0	0		
CDH1	Cell adhesion; Membrane protein, integral; Motility/polarity/chemotaxis; UBIQUITIN LIGASE; Ubiquitin ligase	P09803	12550	Cdh1		mouse	S855	PHOSPHORYLATION	465567	SSLNSSEsDQDQDYD	Cadherin_C	molecular association, regulation	cell adhesion, altered	CTNNB1(INDUCES)		8025	3	0	0		
Dok2	Adaptor/scaffold	O60496	9046	DOK2	8p21.3	human	Y139	PHOSPHORYLATION	449649	CMEENELySSAVTVG		molecular association, regulation		Dok2(INDUCES); Dok1(INDUCES)		6981	1	2	106	Dok1/Dok2 oligomerization required for ERK1/2 and NFAT activation	
Per2	Transcription factor	O54943	18627	Per2		mouse	S659	PHOSPHORYLATION	449331	TLPGKAEsVVSLTSQ		protein stabilization; intracellular localization				8923	3	1	1		
SMTNL1		Q99LM3	68678	Smtnl1		mouse	S301	PHOSPHORYLATION	2755200	RAPERRVsAPSRPRG	MIP-T3	activity, inhibited				2704308	1	1	0	reduces inhibitory effect of SMTNL1 on myosin phosphatase SMPP1M in vitro	
SPTAN1	Adaptor/scaffold; Cytoskeletal protein; Motility/polarity/chemotaxis	P16546	20740	Sptan1		mouse	S1302	PHOSPHORYLATION	14828401	TAQRLIQsHPESAED	Spectrin	molecular association, regulation	cell growth, altered	14-3-3 beta(INDUCES); NCAM1(INDUCES)		14790314	1	1	0	inhibits NCAM-stimulated neurite growth	
H3	DNA binding protein	P68431	8350	HIST1H3A	6p22.1	human	T4	PHOSPHORYLATION	455678	____MARtKQTARKS		molecular association, regulation; intracellular localization	cell cycle regulation; chromatin organization, altered; cytoskeletal reorganization; transcription, altered	TAF140(DISRUPTS); survivin(INDUCES); Borealin(INDUCES)		3394326; 18902800; 5807; 15658707; 18378518; 2618200	18	1	0	H3T4-p antagonizes binding of TAF140 to H3K4me3 and association with mitotic chromosomes.; necessary for the the chromosomal passenger complex (CPC) accumumulation at the centromeres; Oveerexpression of VRK1 induces nuclear condensation, and VRK1 is differentially localized during the cell cycle.; during mitosis	
TRAF2	Autophagy; EC 6.3.2.-; Ligase; UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase	Q12933	7186	TRAF2	9q34	human	T117	PHOSPHORYLATION	471341	DGCTWKGtLKEYESC		activity, induced				9117	2	0	0		
4E-BP1	Translation; Translation initiation	Q62622	116636	Eif4ebp1		rat	S64	PHOSPHORYLATION	447527	FLMECRNsPVAKTPP	eIF_4EBP	molecular association, regulation	translation, altered	eIF4E(DISRUPTS)		6650; 842	60	27	7		
PKD3	EC 2.7.11.13; KINASE; Kinase, protein; Protein kinase, CAMK; Protein kinase, Ser/Thr (non-receptor)	O94806	23683	PRKD3	2p21	human	S735	PHOSPHORYLATION	456756	GEKSFRRsVVGTPAY	Pkinase	enzymatic activity, induced				6867	1	26	22		
PAG	Adaptor/scaffold; Membrane protein, integral	Q9JM80	64019	Pag1		rat	Y381	PHOSPHORYLATION	463949	GEEPEPDyEAIQTLN		intracellular localization	cytoskeletal reorganization; cell growth, altered			6277005; 4338204	3	9	90		
CD19	Cell surface; Membrane protein, integral	P15391	930	CD19	16p11.2	human	Y500	PHOSPHORYLATION	447638	TSLGSQSyEDMRGIL		molecular association, regulation		Lyn(INDUCES); VAV1(INDUCES); PIK3CA(INDUCES)		845	5	3	15		
RalB	G protein; G protein, monomeric, Ras; GTPase activating protein, Ras	P11234	5899	RALB	2q14.2	human	S198	PHOSPHORYLATION	16827200	KSSKNKKsFKERCCL	YTH	intracellular localization	carcinogenesis, altered; cell motility, altered; cytoskeletal reorganization; cell growth, altered			15785200	1	0	0	necessary for the development of experimental lung metastasis of human bladder cancer cells	
EHHADH	Amino Acid Metabolism - lysine degradation; Amino Acid Metabolism - tryptophan; Amino Acid Metabolism - valine, leucine and isoleucine degradation; Carbohydrate Metabolism - butanoate; Carbohydrate Metabolism - propanoate; EC 1.1.1.35; EC 4.2.1.17; EC 5.3.3.8; Isomerase; Lipid Metabolism - fatty acid; Lyase; Mitochondrial; Other Amino Acids Metabolism - beta-alanine; Oxidoreductase; Secondary Metabolites Metabolism - limonene and pinene degradation	Q08426	1962	EHHADH	3q26.3-q28	human	K165	ACETYLATION	14319820	ILADEALkLGILDKV	ECH	enzymatic activity, induced				12513600	0	1	0		
MAD2L1	Cell cycle regulation	Q13257	4085	MAD2L1	4q27	human	S170	PHOSPHORYLATION	11280301	VPEKWEEsGPQFITN	HORMA; ATG13	molecular association, regulation; protein conformation	cell cycle regulation	Mad1(DISRUPTS)		10294003; 17431518	2	0	0		
CLOCK	ACETYLTRANSFERASE; Acetyltransferase; DNA binding protein; EC 2.3.1.48; Transcription factor	O15516	9575	CLOCK	4q12	human	S434	PHOSPHORYLATION	12059703	SPTPSASsRSSRKSS		protein degradation				12021324	1	0	0		
CEACAM1	Cell adhesion; Immunoglobulin superfamily; Membrane protein, integral; Motility/polarity/chemotaxis	P16573	81613	Ceacam1		rat	Y513	PHOSPHORYLATION	451429	SSPTETVySVVKKK_		activity, induced				2572	2	0	37	Phosphorylation of CEACAM1 induces Ca2+/Mg2+-dependent ecto ATPase activity. 	
IL16	Cytokine; DNA binding protein; Motility/polarity/chemotaxis	Q14005	3603	IL16	15q26.3	human	T757	PHOSPHORYLATION	11280303	TQGHPDGtPPKLDTA		intracellular localization	cell cycle regulation			10303908	1	0	0	regulate nuclear localization	
FOXO4	DNA binding protein; Transcription factor	P98177	4303	FOXO4	Xq13.1	human	T32	PHOSPHORYLATION	455572	QSRPRSCtWPLPRPE		intracellular localization	transcription, inhibited			8512	5	6	31		
Ig-alpha	Immunoglobulin superfamily; Membrane protein, integral	P11912	973	CD79A	19q13.2	human	Y210	PHOSPHORYLATION	447752	SRGLQGTyQDVGSLN		molecular association, regulation		Nck1(INDUCES)		28722132	6	4	31	Akt activation	
Mad1	DNA binding protein; Transcription, coactivator/corepressor	Q05195	4084	MXD1	2p13-p12	human	S145	PHOSPHORYLATION	2807903	IERIRMDsIGSTVSS	DUF848; bZIP_Maf	protein degradation; molecular association, regulation	cell cycle regulation; transcription, induced; cell growth, altered		DNA(INDUCES)	2807208; 9385201	2	0	0	inhibits MAD1-mediated transcription repression 	
PPAR-gamma	DNA binding protein; Nuclear receptor	P37231	5468	PPARG	3p25	human	S112	PHOSPHORYLATION	448062	AIKVEPAsPPYYSEK		protein degradation	cell differentiation, altered; transcription, altered; transcription, inhibited; cell growth, altered			4008; 5952; 1248; 1969106	14	0	0	Phosphorylation site-deficitent (S112A) PPAR-gamma is more stable in the presence of gastrin and does not inhibit growth as well.	
p16-INK4A	Cell cycle regulation	P42771	1029	CDKN2A	9p21	human	S7	PHOSPHORYLATION	448829	_MEPAAGsSMEPSAD		protein stabilization				18119108	3	0	0		
Fos	DNA binding protein; Motility/polarity/chemotaxis; Transcription factor	P12841	314322	Fos		rat	T331	PHOSPHORYLATION	448484	CTPVVTCtPSCTTYT		activity, induced; molecular association, regulation	transcription, altered		DNA(INDUCES)	2626208	4	0	0		
ARAP3	GTPase activating protein, ARF; GTPase activating protein, Rac/Rho; Motility/polarity/chemotaxis	Q8R5G7	106952	Arap3		mouse	Y1399	PHOSPHORYLATION	454957	DELEEPVyEEPVYEE			cell motility, altered; cytoskeletal reorganization			4350	3	0	0		
AEBP1	Secreted; Secreted, signal peptide; Transcription factor	Q640N1	11568	Aebp1		mouse	T1003	PHOSPHORYLATION	455321	VDPSRPMtPQQRRMQ		activity, induced	transcription, inhibited			4431	1	0	0		
ITGB3	Cell adhesion; Membrane protein, integral; Motility/polarity/chemotaxis	O54890	16416	Itgb3		mouse	Y784	PHOSPHORYLATION	448013	STFTNITyRGT____	Integrin_b_cyt	molecular association, regulation; protein processing; activity, inhibited	cell adhesion, altered	Shc1(INDUCES)		5298; 2512002; 8535	16	2	6		
Fos	DNA binding protein; Motility/polarity/chemotaxis; Transcription factor	P01101	14281	Fos		mouse	T232	PHOSPHORYLATION	448491	GGLPEAStPESEEAF		activity, induced	transcription, induced			1022	5	0	0		
RACK1	Adaptor/scaffold; G protein; G protein, heterotrimeric; G protein, heterotrimeric beta WD; Motility/polarity/chemotaxis; Nuclear receptor co-regulator	P63244	10399	GNB2L1	5q35.3	human	S146	PHOSPHORYLATION	999602	KYTVQDEsHSEWVSC	WD40	protein conformation				970065	1	0	0	S146 phosphoirylation promotes dimerization of RACK1 and degredation of HIF-1 alpha.	
PDGFRA	EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Protein kinase, TK; Protein kinase, tyrosine (receptor)	P16234	5156	PDGFRA	4q12	human	Y572	PHOSPHORYLATION	448437	ISPDGHEyIYVDPMQ		molecular association, regulation		Src(INDUCES)		2852641	2	4	17		
RNF7	EC 6.3.2.-; Ligase; Motility/polarity/chemotaxis; UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase	Q9UBF6	9616	RNF7	3q22-q24	human	T10	PHOSPHORYLATION	449925	DVEDGEEtCALASHS		protein degradation	cell cycle regulation			8160; 2467	2	0	1	Phosphorylation of T10 of CKBBP1 is required for efficient degradation of I-kappa-B-alpha and P27/Kip1	
Shc3	Adaptor/scaffold; Motility/polarity/chemotaxis	Q92529	53358	SHC3	9q22.1	human	Y341	PHOSPHORYLATION	451254	GDGSDHPyYNSIPSK			apoptosis, inhibited			6002	3	0	3		
LATS1	EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor)	O95835	9113	LATS1	6q25.1	human	S909	PHOSPHORYLATION	457594	HQRCLAHsLVGTPNY	Pkinase	enzymatic activity, induced				7117	6	0	4		
AATF	Transcription factor	Q9NY61	26574	AATF	17q12	human	S143	PHOSPHORYLATION	3753301	SKKSRSHsAKTPGFS		protein stabilization; molecular association, regulation	apoptosis, inhibited; transcription, altered	NFkB-p65(INDUCES)	DNA(INDUCES)	9225	1	0	1		
TRPV1	Channel, cation; Membrane protein, integral; Membrane protein, multi-pass; Receptor, misc.	O35433	83810	Trpv1		rat	S116	PHOSPHORYLATION	454886	PRLYDRRsIFDAVAQ		receptor desensitization, altered				6154	6	0	0		
SPIN1	DNA binding protein	Q9Y657	10927	SPIN1	9q22.1	human	T120	PHOSPHORYLATION	471338	VLPDRVAtSRISDAH	Auxin_resp	protein stabilization; protein conformation	cell cycle regulation			9293	1	0	0		
SSTR2	GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR	P30875	20606	Sstr2		mouse	Y312	PHOSPHORYLATION	450820	SCANPILyAFLSDNF	7tm_1	molecular association, regulation		SHP-2(INDUCES)		3042	1	0	0		
STAT5A	DNA binding protein; Motility/polarity/chemotaxis; Transcription factor	P42229	6776	STAT5A	17q11.2	human	Y694	PHOSPHORYLATION	447767	LAKAVDGyVKPQIKQ		activity, induced	transcription, altered			7119508; 2195702	88	24	2145		
GCH1	Cofactor and Vitamin Metabolism - folate biosynthesis; EC 3.5.4.16; Hydrolase	P22288	29244	Gch1		rat	T231	PHOSPHORYLATION	10428811	VFREDPKtREEFLTL		intracellular localization; enzymatic activity, inhibited				10353908	1	1	0		
FOXO3A	Autophagy; DNA binding protein; Transcription factor	O43524	2309	FOXO3	6q21	human	S7	PHOSPHORYLATION	9318032	_MAEAPAsPAPLSPL		intracellular localization	cell cycle regulation			22463940	1	7	18		
CAMKK1	EC 2.7.11.17; KINASE; Kinase, protein; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor)	Q8N5S9	84254	CAMKK1	17p13.2	human	S74	PHOSPHORYLATION	452115	SLSARKLsLQERPAG		molecular association, regulation; enzymatic activity, inhibited; enzymatic activity, induced		14-3-3 eta(INDUCES)		2852658; 1968358	3	6	7	activity toward PKIV peptide; 14-3-3 inhibits CAMKK1 activity. ;  replacement of S74 to A or D caused an increase in the enzyme activity	
VEGFR1	EC 2.7.1.112; EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Protein kinase, TK; Protein kinase, tyrosine (receptor)	P17948	2321	FLT1	13q12	human	Y1213	PHOSPHORYLATION	448209	GSSDDVRyVNAFKFM		molecular association, regulation; enzymatic activity, induced		PLCG1(INDUCES); SHP-2(INDUCES); Grb2(INDUCES)		1403; 1404	4	0	5		
P130Cas	Adaptor/scaffold; Motility/polarity/chemotaxis	Q63767	25414	Bcar1		rat	Y347	PHOSPHORYLATION	448721	APGSQDIyDVPPVRG			cell motility, altered			2671	8	28	706		
TIEG2	C2H2-type zinc finger protein; DNA binding protein; Transcription factor	O14901	8462	KLF11	2p25	human	S111	PHOSPHORYLATION	456009	LCITPPQsPDLVEPS		molecular association, regulation		SIN3A(DISRUPTS)		6578	1	0	0		
ABCG2	Membrane protein, integral; Membrane protein, multi-pass; Transporter	Q9UNQ0	9429	ABCG2	4q22	human	T362	PHOSPHORYLATION	1818104	GEKKKKItVFKEISY		activity, induced; molecular association, regulation; intracellular localization		ABCG2(INDUCES)		1713114	1	0	0	drug resistance/efflux	
p53	Activator protein; DNA binding protein; Motility/polarity/chemotaxis; Nuclear receptor co-regulator; Transcription factor; Tumor suppressor	P04637	7157	TP53	17p13.1	human	K164	ACETYLATION	2793003	VRAMAIYkQSQHMTE	P53		apoptosis, induced; transcription, altered			2790309; 7647800	3	1	0	 ; ZNF420 (Apak) represses p53 activity by attenuating its acetylation ;  p53 8KR mutant can be still degraded by Mdm2; p53 8KR mutation (K120/164/370/372/373/381/382/386R) impairs p53-dependent transcription	
PKG1	EC 2.7.11.12; KINASE; Kinase, protein; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor)	Q13976	5592	PRKG1	10q11.2	human	T59	PHOSPHORYLATION	448837	THIGPRTtRAQGISA	Med4	enzymatic activity, induced				2004	3	0	0		
Cbl	Adaptor/scaffold; EC 6.3.2.-; EC 6.3.2.19; Ligase; Motility/polarity/chemotaxis; UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase	P22681	867	CBL	11q23.3	human	S639	PHOSPHORYLATION	4704602	PDVPRLGsTFSLDTS		molecular association, regulation		14-3-3 eta(INDUCES)		10144203	0	2	1		
p300	ACETYLTRANSFERASE; Acetyltransferase; EC 2.3.1.48; Motility/polarity/chemotaxis; Nuclear receptor co-regulator; Transcription, coactivator/corepressor	Q09472	2033	EP300	22q13.2	human	S2279	PHOSPHORYLATION	486262	PVQPNPMsPQQHMLP		molecular association, regulation; enzymatic activity, induced	transcription, altered	SP1(NOT_REPORTED)		12065	3	0	0	 controls EGF-induced keratin 16 promoter activity ; regulates HAT activity of p300	
CCNB1	Activator protein; Cell cycle regulation	P14635	891	CCNB1	5q12	human	S126	PHOSPHORYLATION	448814	PILVDTAsPSPMETS	Trypan_PARP	intracellular localization			DNA(INDUCES)	25573559; 12778806	5	1	0	translocation to the nucleus; enhances nuclear import	
MDM2	EC 6.3.2.-; EC 6.3.2.19; Inhibitor protein; Ligase; UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase	Q00987	4193	MDM2	12q14.3-q15	human	Y394	PHOSPHORYLATION	455777	QSQESEDySQPSTSS			apoptosis, induced; transcription, altered			6040	2	0	0		
TRPC4	Channel, calcium; Membrane protein, integral; Membrane protein, multi-pass	Q9UBN4	7223	TRPC4	13q13.3	human	Y972	PHOSPHORYLATION	456714	DTVTHEDyVTTRL__		activity, induced; intracellular localization		NHERF(INDUCES)		6875	1	0	0		
PCAF	ACETYLTRANSFERASE; Acetyltransferase; EC 2.3.1.48; Nuclear receptor co-regulator	Q92831	8850	KAT2B	3p24	human	K441	ACETYLATION	458987	SHVLEEAkKPRVMGD		enzymatic activity, induced				7551	1	0	0	in vitro	
CACNG2	Channel, calcium; Membrane protein, integral; Membrane protein, multi-pass	O88602	12300	Cacng2		mouse	S228	PHOSPHORYLATION	455313	SAITRIPsYRYRYQR	Tetraspannin	activity, induced; intracellular localization				22913905; 4485	1	1	2	AMPAR immobilization in synaptic membrane; enhances AMPA receptor responses and is required for long-term potentiation	
GRK2	EC 2.7.11.15; KINASE; Kinase, protein; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor)	P25098	156	ADRBK1	11q13.1	human	S670	PHOSPHORYLATION	447725	KMKNKPRsPVVELSK		protein degradation; molecular association, regulation	cell cycle regulation; cell growth, altered	Pin1(INDUCES)		12662613	3	16	17		
ER-alpha	DNA binding protein; Nuclear receptor	P03372	2099	ESR1	6q25.1	human	Y219	PHOSPHORYLATION	12620700	SIQGHNDyMCPATNQ	zf-C4	protein stabilization; molecular association, regulation	carcinogenesis, induced; cell growth, induced; transcription, induced	ER-alpha(DISRUPTS)	DNA(DISRUPTS)	12558701	1	0	0		
AHCYL1	Amino Acid Metabolism - cysteine and methionine; EC 3.3.1.1; Hydrolase; Other Amino Acids Metabolism - selenoamino acid	Q80SW1	229709	Ahcyl1		mouse	S70	PHOSPHORYLATION	467247	LSRSISQsSTDSYSS	Utp11	molecular association, regulation		IP3R1(INDUCES)		8190	1	0	0	binding to IP3R1 supresses its binding to IP3 and inhibits IP3-induced calcium release 	
Cdc25C	EC 3.1.3.48; Motility/polarity/chemotaxis; PHOSPHATASE; Protein phosphatase, dual-specificity	P30307	995	CDC25C	5q31	human	T67	PHOSPHORYLATION	448420	LSILSGGtPKRCLDL		protein degradation; molecular association, regulation	cell cycle regulation; cell adhesion, altered	NEDD4(INDUCES); Pin1(INDUCES)		2459; 626; 15331005	3	3	2	phosphorylated during mitosis and localizes in the nucleus during prophase, and associates with condensed chromatin	
NEUROD1	DNA binding protein; Transcription factor	Q60867	18012	Neurod1		mouse	S162	PHOSPHORYLATION	465677	EILRSGKsPDLVSFV	DUF2146; Neuro_bHLH		transcription, induced			8116	1	0	0		
Huntingtin	Cytoskeletal protein	P42858	3064	HTT	4p16.3	human	S429	PHOSPHORYLATION	2020877	ELIAGGGsSCSPVLS		protein degradation				25348515	1	3	1	increased cell viability and reduced protein accumulation in S429A mutant	
LAIR-1	Membrane protein, integral; Receptor, misc.	Q6GTX8	3903	LAIR1	19q13.4	human	Y281	PHOSPHORYLATION	449313	PMAESITyAAVARH_		molecular association, regulation		SHP-1(INDUCES)		2177	1	3	331		
Ets-1	DNA binding protein; Motility/polarity/chemotaxis; Transcription factor	P14921	2113	ETS1	11q23.3	human	S251	PHOSPHORYLATION	449316	GKLGGQDsFESIESY		molecular association, regulation; activity, inhibited	transcription, inhibited		DNA(DISRUPTS)	2182	2	6	0		
CACNA1C	Channel, calcium; Membrane protein, integral; Membrane protein, multi-pass	P22002	24239	Cacna1c		rat	Y2148	PHOSPHORYLATION	450658	PEDESCVyALGRGRS		activity, induced; molecular association, regulation		ITGB1(INDUCES)		17675039; 7729; 3119	3	0	0		
CD5	Cell surface; Membrane protein, integral	P13379	12507	Cd5		mouse	Y486	PHOSPHORYLATION	447775	DNSSDSDyDLQVAQR		molecular association, regulation		PIK3R1(NOT_REPORTED)		2710	2	2	87		
HSL	EC 3.1.1.79; Lipase	P15304	25330	Lipe		rat	S863	PHOSPHORYLATION	448803	LTESMRRsVSEAALA		enzymatic activity, induced				2860	21	6	2		
TNNI3	Actin binding protein; Motility/polarity/chemotaxis; Motor protein	P48787	21954	Tnni3		mouse	T144	PHOSPHORYLATION	451483	RGKFKRPtLRRVRIS	Troponin	activity, induced; activity, inhibited; protein conformation; phosphorylation	cytoskeletal reorganization			7134; 7889902; 4862629; 8954	18	1	1		
MCM4	DNA replication; EC 3.6.4.12	P49717	17217	Mcm4		mouse	T19	PHOSPHORYLATION	448634	SSRRGRVtPTQSLRS		activity, inhibited				1850	3	13	8	Phosphorylation of T19 correlates with lowered level of DNA helicase activity of the purified Mcm4,6,7 complex.	
DDX58	EC 3.6.1.-; EC 3.6.4.13; Hydrolase	O95786	23586	DDX58	9p12	human	T170	PHOSPHORYLATION	12613700	DKENWPKtLKLALEK		molecular association, regulation; ubiquitination; protein conformation	transcription, induced	TRIM25(DISRUPTS); MAVS(DISRUPTS)		27305548; 12524178; 27132411	5	1	0	Phosphorylation inhibits antiviral signaling.; supresses TRIM25-mediated ubiquitination of DDX58 and inhibits anti-viral signaling; T170 phosphorylation may prevent ubiquitination of K172.	
ERK2	EC 2.7.11.24; KINASE; Kinase, protein; Protein kinase, CMGC; Protein kinase, Ser/Thr (non-receptor)	P63086	116590	Mapk1		rat	T183	PHOSPHORYLATION	447593	HDHTGFLtEYVATRW	Pkinase; YukC	activity, induced; molecular association, regulation; intracellular localization; enzymatic activity, induced	translation, altered; cytoskeletal reorganization; cell adhesion, altered; cell growth, altered	MEK1(INDUCES)		6295; 4862613; 1165; 5955619; 7472; 19016901; 4914029; 668; 7848; 13788306; 5755; 7910522; 5718	954	60	2332	regulate cell proliferation in dentate gyrus following ischemia;  phenylphrine induces protein synthesis; activation of MEK1 and ERK1/2; colocalized in glucose induced filipodia extensions, leading to insulin secretion	
P2X3	Channel, ligand-gated; Membrane protein, integral; Membrane protein, multi-pass	P56373	5024	P2RX3	11q12	human	S269	PHOSPHORYLATION	458894	FTRLDSVsEKSSVSP	P2X_receptor	receptor desensitization, altered				7456	1	0	0		
5-HT(2C)	GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR	P08909	25187	Htr2c		rat	S458	PHOSPHORYLATION	449090	NVVSERIsSV_____		molecular association, regulation; receptor desensitization, altered		MPDZ(DISRUPTS)		2121; 2122	2	0	0		
CACNB2	Channel, calcium	Q8VGC3	116600	Cacnb2		rat	T549	PHOSPHORYLATION	470081	RGLSRQEtFDSETQE		activity, induced				8964	5	3	17	increases the probability of channel being open (facilitation)	
PSD-95	Adaptor/scaffold	P31016	29495	Dlg4		rat	S73	PHOSPHORYLATION	471390	ITLERGNsGLGFSIA	PDZ	molecular association, regulation; intracellular localization; activity, inhibited	cell growth, altered	NMDAR2A(DISRUPTS)		9103; 5930030	2	4	0	enhances trafficking of SHANK2 and PSD-95 itself	
EXO1	EC 3.1.-.-; Hydrolase	Q9UQ84	9156	EXO1	1q42-q43	human	S454	PHOSPHORYLATION	1240800	SEGNKSLsFSEVFVP		protein degradation				1223901	1	1	0		
TNNI3	Actin binding protein; Motility/polarity/chemotaxis; Motor protein	P19429	7137	TNNI3	19q13.4	human	T143	PHOSPHORYLATION	451483	RGKFKRPtLRRVRIS	Troponin	molecular association, regulation; protein conformation		TNNC1(DISRUPTS); C16orf82(INDUCES); TNC(INDUCES)		8406; 6702300	18	1	1		
KATNA1	EC 3.6.4.3; Hydrolase; Motility/polarity/chemotaxis	O75449	11104	KATNA1	6q25.1	human	T133	PHOSPHORYLATION	26401201	HGNRPSTtVRVHRSS		ubiquitination	cell cycle regulation			25779408	1	0	0		
ERK5	EC 2.7.11.24; KINASE; Kinase, protein; Protein kinase, CMGC; Protein kinase, Ser/Thr (non-receptor)	Q9WVS8	23939	Mapk7		mouse	S486	PHOSPHORYLATION	450251	LKAALLKsLRSRLRD		molecular association, regulation; enzymatic activity, inhibited		14-3-3 beta(INDUCES)		2954	2	1	0		
PDGFRB	EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Protein kinase, TK; Protein kinase, tyrosine (receptor)	P09619	5159	PDGFRB	5q33.1	human	Y763	PHOSPHORYLATION	448850	DMKGDVKyADIESSN	Pkinase_Tyr	molecular association, regulation		SHP-2(INDUCES)		6024; 1173023; 2023	6	1	2		
CSFR	EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Protein kinase, TK; Protein kinase, tyrosine (receptor)	P07333	1436	CSF1R	5q32	human	Y723	PHOSPHORYLATION	448364	SSQGVDTyVEMRPVS	Pkinase_Tyr	molecular association, regulation		Cbl(INDUCES)		4024	14	0	1		
NDEL1	Microtubule binding protein; Protease	Q9GZM8	81565	NDEL1	17p13.1	human	T219	PHOSPHORYLATION	468252	ASLSLPAtPVGKGTE	NUDE_C	molecular association, regulation; intracellular localization		PAFAH1B1(INDUCES)		9081	3	10	3		
KEAP1	Endoplasmic reticulum; Motility/polarity/chemotaxis; Transcription regulation; Ubiquitin conjugating system	Q9Z2X8	50868	Keap1		mouse	Y141	PHOSPHORYLATION	2708401	ERLIEFAyTASISVG	BTB	protein stabilization	transcription, altered			2704331	1	0	0	INrf2 Y141A mutant fails to degrade Nrf2	
SLC9A5	Membrane protein, integral; Membrane protein, multi-pass; Transporter	Q14940	6553	SLC9A5	16q22.1	human	S711	PHOSPHORYLATION	20832303	EEEEESDsSETEKED		molecular association, regulation; activity, inhibited	endocytosis, induced	ARRB1(INDUCES)		20655009	1	0	0	In intact cells ARRB1 ST/AA mutant retained ability to form a complex. 	
FGD1	Guanine nucleotide exchange factor, misc.	P98174	2245	FGD1	Xp11.21	human	S205	PHOSPHORYLATION	3193805	LAPRAEAsPSSAAVS			cell motility, altered			18021030	2	1	0		
LAT iso2	Adaptor/scaffold; Membrane protein, integral	O43561-2	27040	LAT	16p11.2	human	Y132	PHOSPHORYLATION	447760	DDYHNPGyLVVLPDS	LAT	activity, induced; molecular association, regulation; phosphorylation	cell differentiation, altered; transcription, altered	PLCG1(INDUCES); Grb2(INDUCES)		2891; 1909	13	0	1	leads to ERK phosphorylation, NF-AT transcription	
LRP6	Membrane protein, integral; Receptor, misc.	O75581	4040	LRP6	12p13.2	human	S1490	PHOSPHORYLATION	456289	AILNPPPsPATERSH		molecular association, regulation; phosphorylation	transcription, altered	axin 1(INDUCES); caveolin-1(INDUCES)		2466201; 6740300; 6674	10	5	54		
SPT5	Transcription, coactivator/corepressor	O00267	6829	SUPT5H	19q13	human	T768	PHOSPHORYLATION	458814	MTSTYGRtPMYGSQT	CTD		transcription, altered			7460	1	0	13	required for c-fos induction and activation in vivo	
GPIbA	Cell adhesion; Cell surface; Membrane protein, integral	P07359	2811	GP1BA	17pter-p12	human	S606	PHOSPHORYLATION	1983279	GRRPSALsQGRGQDL		molecular association, regulation	cytoskeletal reorganization	14-3-3 zeta(INDUCES)		8534; 13164200	3	6	10	cell spreading (not adhering efficiency)	
HuR	RNA binding protein	P70372	15568	Elavl1		mouse	S318	PHOSPHORYLATION	2246702	GDKILQVsFKTNKSH		molecular association, regulation	translation, induced	MYH9(INDUCES)		28722424	6	1	0	association is RNA dependent;  Ang II mediated recruitment to polysomes	
E2F4	DNA binding protein	E1BUH4		E2F4		chicken	T263	PHOSPHORYLATION	25571900	STQPSTPtPSSTQDH			cell cycle regulation; apoptosis, induced			25561501	1	0	0		
Abi-1	Adaptor/scaffold; Motility/polarity/chemotaxis	Q8IZP0	10006	ABI1	10p11.2	human	Y213	PHOSPHORYLATION	449523	PPTVPNDyMTSPARL		molecular association, regulation	endocytosis, altered	PIK3R1(INDUCES)		15031300	3	25	709		
NEK3	EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor)	Q9R0A5	23954	Nek3		mouse	T477	PHOSPHORYLATION	454368	PRLDEEDtDFEEDNE		acetylation	cytoskeletal reorganization			9201027	1	18	12	; regulates neuronal morphology and polarity;  regulates the level of alpha-tubulin acetylation (Ac-tubulin)	
PSF	Nuclear receptor co-regulator; RNA binding protein; RNA splicing	P23246	6421	SFPQ	1p34.3	human	Y293	PHOSPHORYLATION	482843	RRPGEKTyTQRCRLF		intracellular localization	transcription, altered; cell growth, altered		RNA(INDUCES)	11806	1	1	0	relocalization from nucleus to cytoplasm	
p63 iso2	DNA binding protein; Transcription factor	Q9H3D4-2	8626	TP63	3q28	human	S68	PHOSPHORYLATION	451601	TFDALSPsPAIPSNT		protein degradation	cell growth, inhibited			27257046	1	0	0	Anti-clonogenic effects of TGFB require S66,68 phosphorylation.	
TDP43	RNA binding protein	Q13148	23435	TARDBP	1p36.22	human	S409	PHOSPHORYLATION	3084616	GSSMDSKsSGWGM__		molecular association, regulation; intracellular localization	autophagy, altered	TDP43(DISRUPTS)		17675062; 8164809; 6331344	18	0	0	accumulates in insoluble cytoplasmic aggregates; phosphomimetic S410/409D mutant reduces TARDBP aggregation and autophagy; found in inclusion bodies	
DRD2	GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR	P14416	1813	DRD2	11q23	human	T225	PHOSPHORYLATION	13270200	RRRKRVNtKRSSRAF	7tm_1; Rifin_STEVOR	receptor internalization, altered				13159403	1	0	0		
CD45	EC 3.1.3.48; Membrane protein, integral; Motility/polarity/chemotaxis; PHOSPHATASE; Receptor protein phosphatase, tyrosine	P08575	5788	PTPRC	1q31-q32	human	Y1216	PHOSPHORYLATION	451644	MVSTFEQyQFLYDVI	Y_phosphatase	activity, induced; molecular association, regulation		Lck(INDUCES)		3721	1	0	1		
NCBP1	RNA processing; Spliceosome; Translation	Q09161	4686	NCBP1	9q34.1	human	S7	PHOSPHORYLATION	9764056	_MSRRRHsDENDGGQ			RNA splicing, altered			12482263	1	9	5		
IL-1RA	EC 2.7.11.25; Membrane protein, integral; Receptor, cytokine	P14778	3554	IL1R1	2q12	human	Y496	PHOSPHORYLATION	450889	ELEKIQDyEKMPESI	TIR	molecular association, regulation		PIK3R1(INDUCES)		3173	1	0	0		
AQP4	Channel, misc.; Membrane protein, integral; Membrane protein, multi-pass	P47863	25293	Aqp4		rat	S276	PHOSPHORYLATION	465556	AAQQTKGsYMEVEDN		protein degradation; molecular association, regulation; intracellular localization		AP3M1(INDUCES)		8019	1	5	0		
RAF1	EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, Ser/Thr (non-receptor); Protein kinase, TKL	Q99N57	110157	Raf1		mouse	S338	PHOSPHORYLATION	447742	RPRGQRDsSYYWEIE		enzymatic activity, induced				4753; 1758; 6905	73	2	6		
tau	Cytoskeletal protein	P19332	29477	Mapt		rat	S667	PHOSPHORYLATION	449104	RVQSKIGsLDNITHV	Tubulin-binding		cytoskeletal reorganization			4214826	19	12	0		
IKKA	EC 2.7.11.10; KINASE; Kinase, protein; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor)	O15111	1147	CHUK	10q24-q25	human	S176	PHOSPHORYLATION	447778	AKDVDQGsLCTSFVG	Pkinase	enzymatic activity, induced				1326	16	0	0	S176A mutant acts as dominant negative inhibitor of cytokine-mediated NFkB activation.
	
GYS1	Carbohydrate Metabolism - starch and sucrose; EC 2.4.1.11; Transferase	P13834	100008660	GYS1		rabbit	S11	PHOSPHORYLATION	451605	SRTLSVSsLPGLEDW		enzymatic activity, inhibited				4917204; 3738	9	1	1		
SULT4A1	EC 2.8.2.-; Transferase	Q9BR01	25830	SULT4A1	22q13.2	human	T8	PHOSPHORYLATION	2021049	MAESEAEtPSTPGEF		protein degradation; molecular association, regulation		Pin1(INDUCES)		16824201; 9980405	2	0	0		
MeCP2	Transcription, coactivator/corepressor	Q9Z2D6	17257	Mecp2		mouse	S421	PHOSPHORYLATION	470075	EKMPRGGsLESDGCP			chromatin organization, altered; cytoskeletal reorganization			21509600	6	4	0	 S421A mutant mice have behavioral defects in response to novel experience.;  neuronal activation leading to S421 phosphorylation and global chromatin response; Regulates dendritic remodeling, membrane depolarization	
Rb-like 2	Transcription, coactivator/corepressor	Q08999	5934	RBL2	16q12.2	human	S1068	PHOSPHORYLATION	449740	HKNETMLsPREKIFY		molecular association, regulation	cell cycle regulation	E2F4(DISRUPTS)		1200	2	4	11		
STMN2	Cytoskeletal protein	P55821	20257	Stmn2		mouse	S62	PHOSPHORYLATION	450174	ELILKPPsPISEAPR	Stathmin		cell motility, altered; cytoskeletal reorganization			18410818	5	5	0	phospho-mimetic S62D/S73D mutant stabilizes microtubules	
Gab1	Adaptor/scaffold; Motility/polarity/chemotaxis	Q13480	2549	GAB1	4q31.21	human	Y373	PHOSPHORYLATION	447945	ASDTDSSyCIPTAGM		molecular association, regulation		CDK6(INDUCES)		11387287	4	8	275	promotes HGF-induced DNA synthesis	
LATS2	EC 2.7.11.1; KINASE; Kinase, protein; Nuclear receptor co-regulator; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor)	Q9NRM7	26524	LATS2	13q11-q12	human	S380	PHOSPHORYLATION	3213669	ATLARRDsLQKPGLE		intracellular localization				21126706	2	3	4	 chromosome segregation and cytokinesis ; translocation from the centrosome to the chromosome and spindle during mitosis	
PPP2R5D	Motility/polarity/chemotaxis; Protein phosphatase, regulatory subunit	Q7TNL5	21770	Ppp2r5d		mouse	S566	PHOSPHORYLATION	457390	KVLLRRKsELPQDVY		enzymatic activity, induced				12778805; 2706604	4	17	321		
InsR	EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Protein kinase, TK; Protein kinase, tyrosine (receptor)	P06213	3643	INSR	19p13.3-p13.2	human	Y999	PHOSPHORYLATION	447685	YASSNPEyLSASDVF		activity, induced; molecular association, regulation; receptor internalization, altered; enzymatic activity, induced; phosphorylation	cell cycle regulation	SOCS3(INDUCES)		6226; 1124; 8571; 3694; 3726; 8589	21	0	0	autophosphorylation; Phosphorylation induces colocalization of the insulin receptor with SOCS-3 at cell surface.; phosphorylation of pp185, activation of glycogen synthesis	
VEGFR3	EC 2.7.1.112; EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Protein kinase, TK; Protein kinase, tyrosine (receptor)	P35916	2324	FLT4	5q35.3	human	Y1063	PHOSPHORYLATION	473000	FGLARDIyKDPDYVR	Pkinase_Tyr	molecular association, regulation; enzymatic activity, induced	apoptosis, inhibited	Shc1(INDUCES); Crk(INDUCES)		25699200; 13974107	2	3	102		
cortactin	Actin binding protein; Cytoskeletal protein; Motility/polarity/chemotaxis	Q14247	2017	CTTN	11q13	human	S298	PHOSPHORYLATION	5014901	EKLAKHEsQQDYSKG	HS1_rep	molecular association, regulation; phosphorylation	cell motility, altered; cytoskeletal reorganization	14-3-3 beta(INDUCES)		14058606; 5014019	3	4	1		
CACNA1B	Channel, calcium; Membrane protein, integral; Membrane protein, multi-pass	Q00975	774	CACNA1B	9q34	human	T421	PHOSPHORYLATION	465546	DVLKRAAtKKSRNDL		activity, inhibited				8301	4	0	0		
SQSTM1	Autophagy; Nuclear receptor co-regulator; Ubiquitin conjugating system	Q64337	18412	Sqstm1		mouse	T272	PHOSPHORYLATION	454787	RSRLTPTtPESSSTG			cell cycle regulation; carcinogenesis, altered			17431509	2	36	244	in Ras-transformed embryonic fibroblasts	
TREK-1	Channel, potassium; Membrane protein, integral; Membrane protein, multi-pass	P97438	16526	Kcnk2		mouse	S300	PHOSPHORYLATION	456160	GDWLRVIsKKTKEEV		activity, inhibited				1968303; 6614	3	0	0	dephosphorylation of this site after mGluR4 activation leads to an increase in TREK-1 activity 	
Smad1	DNA binding protein; Transcription factor	Q15797	4086	SMAD1	4q31	human	S206	PHOSPHORYLATION	451175	SSSTYPHsPTSSDPG	DUF605	protein degradation; molecular association, regulation; ubiquitination; intracellular localization	transcription, altered	YAP1(INDUCES)		3385; 9314; 12066001	3	0	0		
TSAd	Adaptor/scaffold	Q9NP31	9047	SH2D2A	1q21	human	Y305	PHOSPHORYLATION	450668	GEAPSNIyVEVEDEG		molecular association, regulation		Lck(INDUCES)		4042501	1	4	36		
LHX3	DNA binding protein; Transcription factor	Q9UBR4	8022	LHX3	9q34.3	human	Y227	PHOSPHORYLATION	455296	GRQRWGQyFRNMKRS		activity, induced	transcription, induced			4438	1	0	0	no change in binding to DNA or to certain proteins (NLI, PIT1, or MRG1)	
MITF iso8	DNA binding protein; Transcription factor	Q08874-8	17342	Mitf		mouse	S173	PHOSPHORYLATION	467214	PGLTISNsCPANLPN		molecular association, regulation; intracellular localization	transcription, altered	14-3-3 zeta(INDUCES)		8147	1	0	0		
ERK2	EC 2.7.11.24; KINASE; Kinase, protein; Protein kinase, CMGC; Protein kinase, Ser/Thr (non-receptor)	P28482	5594	MAPK1	22q11.21	human	S29	PHOSPHORYLATION	7989100	GPRYTNLsYIGEGAY	Pkinase	molecular association, regulation; enzymatic activity, induced		MEK2(INDUCES); MEK1(INDUCES)		7910507	1	0	0		
EXOSC9	EC 3.1.13.-; RNA processing; Ribonuclease	Q06265	5393	EXOSC9	4q27	human	S392	PHOSPHORYLATION	3194465	QDAPIILsDSEEEEM		molecular association, regulation		SUMO2(INDUCES); SUMO1(INDUCES)		6829202	1	8	1		
PTHR	GPCR, family 2; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR	P25961	56813	Pth1r		rat	S501	PHOSPHORYLATION	2853104	YSYGPMVsHTSVTNV		receptor internalization, altered; activity, inhibited				8759; 2831777	2	0	0		
Tiam1	Guanine nucleotide exchange factor, Rac/Rho; Motility/polarity/chemotaxis	Q60610	21844	Tiam1		mouse	Y829	PHOSPHORYLATION	465610	PQPEEDIyELLYKEI	RBD		cytoskeletal reorganization			8105	2	0	0	important for BDNF-induced neurite outgrowth	
DOCK7	Guanine nucleotide exchange factor, misc.	Q96N67	85440	DOCK7	1p31.3	human	Y1257	PHOSPHORYLATION	2756301	METVPQLyDFTETHN			cell motility, altered			2725504	1	0	0		
VEGFR3	EC 2.7.1.112; EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Protein kinase, TK; Protein kinase, tyrosine (receptor)	P35917	14257	Flt4		mouse	Y1337	PHOSPHORYLATION	2874406	KVFYNNEyGEVSQPC			cell growth, altered			2852616	4	1	2		
sialoprotein 2	Cell adhesion; Motility/polarity/chemotaxis; Secreted; Secreted, signal peptide	P13839		Ibsp		rat	S153	PHOSPHORYLATION	457545	KAPKMKEsDEEEEEE	BSP_II	activity, induced				14058609	2	2	0	important for hydroxyapatite (HA) nucleation	
ZBED3	DNA binding protein	Q3TSB2	72114	Zbed3		mouse	T113	PHOSPHORYLATION	6738703	CPPPPSPtMAAEGDW		molecular association, regulation		axin 1(INDUCES)		6701101	1	0	0	 interaction beween ZBED3 and axin is important for ZBED3 to inhibit beta catenin (CTNNB1) phosphorylation by GSK3 beta  ; activates Wnt signaling	
GRF-1	GTPase activating protein, Rac/Rho; Motility/polarity/chemotaxis; Transcription factor	Q9NRY4	2909	ARHGAP35	19q13.3	human	S1174	PHOSPHORYLATION	7157500	RFASYRTsFSVGSDD		molecular association, regulation; activity, inhibited		Rnd1(DISRUPTS)		6804206	1	1	0		
Rab3IP	Guanine nucleotide exchange factor, Rab	Q96QF0	117177	RAB3IP	12q15	human	S288	PHOSPHORYLATION	4734219	KGHTRNKsTSSAMSG	Sec2p	molecular association, regulation; intracellular localization	cytoskeletal reorganization	EXOC6(INDUCES)		27619345	2	6	0	 inhibits binding to phosphatidylserine; ciliogenesis	
Lu	Membrane protein, integral; Receptor, misc.	P50895	4059	BCAM	19q13.2	human	S621	PHOSPHORYLATION	455912	SGGARGGsGGFGDEC			cell adhesion, altered			6356	1	1	0		
MEF2C	DNA binding protein; Transcription factor	Q8CFN5	17260	Mef2c		mouse	S98	PHOSPHORYLATION	23068100	KGLNGCDsPDPDADD	HJURP_C	molecular association, regulation		Pin1(INDUCES)		15235218	1	6	3	Pin1 binding decreases MEF2C stability and its transcriptional activity	
RAF1	EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, Ser/Thr (non-receptor); Protein kinase, TKL	P05625	396245	RAF1		chicken	Y341	PHOSPHORYLATION	447750	GQRDSSYyWEIEASE		enzymatic activity, induced	apoptosis, inhibited			2941; 5487	28	1	1		
BKR2	GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR	P25023	25245	Bdkrb2		rat	Y352	PHOSPHORYLATION	452100	RKKSREVyQAICRKG		activity, induced; receptor desensitization, altered				7063	3	2	0		
BAP37	Mitochondrial; Nuclear receptor co-regulator; Transcription, coactivator/corepressor	Q99623	11331	PHB2	12p13	human	S91	PHOSPHORYLATION	22342307	RARPRKIsSPTGSKD	Band_7		transcription, induced			22343400	1	3	0	activates MEF2	
CtBP1	Cell cycle regulation; EC 1.1.1.-; Nuclear receptor co-regulator; Oxidoreductase; Transcription, coactivator/corepressor	Q9Z2F5		Ctbp1		rat	S147	PHOSPHORYLATION	455351	REGTRVQsVEQIREV	2-Hacid_dh; 2-Hacid_dh_C	molecular association, regulation		14-3-3 gamma(INDUCES)		25227604	4	1	0	important for PGCs (basolateral post-Golgi carries) fission	
IL4R	Membrane protein, integral; Receptor, cytokine	P24394	3566	IL4R	16p12.1-p11.2	human	Y713	PHOSPHORYLATION	451066	SLGSGIVySALTCHL		molecular association, regulation	apoptosis, inhibited; cell growth, altered	SHIP(INDUCES)		6184; 3287	2	0	0		
SREBP-1 iso4	DNA binding protein; Membrane protein, integral; Membrane protein, multi-pass; Transcription factor	Q9WTN3-4	20787	Srebf1		mouse	S266	PHOSPHORYLATION	458357	IEKRYRSsINDKIVE	HLH	molecular association, regulation	transcription, altered		DNA(DISRUPTS)	7889908	2	0	0	regulates hepatic lipogenesis	
ADRA2A	GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR	P08913	150	ADRA2A	10q25.2	human	S299	PHOSPHORYLATION	456352	DLEESSSsDHAERPP	7tm_1	activity, inhibited				6726	1	2	0		
Irx2	DNA binding protein; Transcription factor	Q9PU52	373975	IRX2		chicken	S65	PHOSPHORYLATION	452192	AAATGFTsPLQYSTD	TFIIA		transcription, altered			4104	1	0	0		
STIM1	Calcium-binding protein; Endoplasmic reticulum; Membrane protein, integral	P70302	20866	Stim1		mouse	S608	PHOSPHORYLATION	3195758	PSVPPGGsPLLDSSH		molecular association, regulation; protein conformation		ORAI1(INDUCES); EB1(INDUCES)		28100400; 28023923	3	6	0	calcium mobilization and EB1-dependent STIM1 multimerization ; regulate store operated calcium entry (SOCE)	
SLC24A2	Membrane protein, integral; Membrane protein, multi-pass; Transporter	O54701	84550	Slc24a2		rat	T166	PHOSPHORYLATION	471069	VPSLTVItEKLGISD	Na_Ca_ex	activity, induced				9038	1	0	0	Mutation to alanine of T476 and either T166 or S504 (or possibly both) eliminates PDBu-induced enhancement (PIE) on the Na(+)/Ca(2+)+K(+) exchanger.	
TUBB	Cytoskeletal protein; Motility/polarity/chemotaxis	P99024	22154	Tubb5		mouse	S172	PHOSPHORYLATION	460692	NTFSVVPsPKVSDTV	Tubulin	molecular association, regulation		TUBB(DISRUPTS)		7744	1	11	1	inhibits tubulin polymerization in vivo and in vitro	
TRPV6	Channel, calcium; Membrane protein, integral; Membrane protein, multi-pass	Q9R186	114246	Trpv6		rat	Y161	PHOSPHORYLATION	473577	YRPHNLIyYGEHPLS	Ank_2	activity, induced				9194	1	0	0	regulates calcium influx	
MDM2	EC 6.3.2.-; EC 6.3.2.19; Inhibitor protein; Ligase; UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase	P23804	17246	Mdm2		mouse	S163	PHOSPHORYLATION	448130	SSRRRSIsETEENTD		intracellular localization	apoptosis, altered; carcinogenesis, altered			17613017; 17630303	30	6	5	Coexpression of S163/183DD with Neu results in faster tumor formation. ; Activated S6K1 and Mdm2 phosphorylation inhibits nuclear entry . 	
PTEN	Carbohydrate Metabolism - inositol phosphate; EC 3.1.3.16; EC 3.1.3.48; EC 3.1.3.67; Motility/polarity/chemotaxis; Nuclear receptor co-regulator; PHOSPHATASE; Phosphatase, lipid; Tumor suppressor	P60484	5728	PTEN	10q23.3	human	Y240	PHOSPHORYLATION	448316	RREDKFMyFEFPQPL	PTEN_C2	enzymatic activity, induced	cell growth, altered			1251	2	0	0		
MLF1IP	Cell cycle regulation	Q71F23	79682	MLF1IP	4q35.1	human	S77	PHOSPHORYLATION	471407	TFDPPLHsTAIYADE		protein degradation	cell cycle regulation; cell growth, altered	PLK1(INDUCES)		9116	1	1	0	p-T78 peptides precipitated with Pl1K. Kinase activity of Plk1 is necessary for the in vivo interaction. The S77- T78 dependent interaction is sufficient to target Plk1 to the kinetochores. P-T78 dependent PBIP1 function is required for chromosome segregation, and is important for activation of spindle assembly checkpoint.	
Srcasm	Adaptor/scaffold	Q923U0	71943	Tom1l1		mouse	Y457	PHOSPHORYLATION	451210	APTTEAVyEEIDGYH		molecular association, regulation		Fyn(INDUCES)		3437	2	1	33		
CCNH	Cell cycle regulation	P51946	902	CCNH	5q13.3-q14	human	S304	PHOSPHORYLATION	12521707	YEDDDYVsKKSKHEE			transcription, altered; cell growth, altered			12482254	1	0	1		
Pyk2	EC 2.7.10.2; KINASE; Kinase, protein; Nuclear receptor co-regulator; Protein kinase, TK; Protein kinase, tyrosine (non-receptor)	Q14289	2185	PTK2B	8p21.1	human	Y906	PHOSPHORYLATION	3091409	CQLPPEGyVVVVKNV	Focal_AT	molecular association, regulation		SHP-2(INDUCES)		8764	1	0	0		
CCDC50 iso2	Inhibitor protein	Q8IVM0	152137	CCDC50	3q28	human	Y146	PHOSPHORYLATION	454596	AYADSYYyEDGGMKP	TAF8_C	molecular association, regulation		EGFR(INDUCES)		3218103	1	4	18	inhibits the down-regulation of EGFR	
MEN1 iso2	Transcription, coactivator/corepressor	O00255-2	4221	MEN1	11q13	human	S543	PHOSPHORYLATION	470121	QVPAPTAsPPPEGPV	Menin	molecular association, regulation		POLR2A(DISRUPTS)		18021024	2	8	2		
ASIC2	Apoptosis; Channel, cation; Membrane protein, integral; Membrane protein, multi-pass	Q16515	40	ASIC2	17q12	human	T39	PHOSPHORYLATION	455992	IFVYGPLtIRRVLWA	ASC; TM	activity, induced				6571	1	0	0		
Casp9	Apoptosis; EC 3.4.22.62; Protease	Q9R0T0	12371	Casp9		mouse	S348	PHOSPHORYLATION	484609	SQGRTLDsDSEPDAV	Peptidase_C14	protein processing	apoptosis, inhibited			2807212	1	2	0	inhibits protein cleavage by caspase 8	
PTP-SL iso2	EC 3.1.3.48; Membrane protein, integral; Motility/polarity/chemotaxis; PHOSPHATASE; Protein phosphatase, tyrosine (non-receptor)	Q62132-2	19279	Ptprr		mouse	T253	PHOSPHORYLATION	450119	EPFVAVStPREKVAM		molecular association, regulation				1616	1	0	1		
MAD1L1	Cell cycle regulation; Cytoskeletal protein	Q9Y6D9	8379	MAD1L1	7p22	human	T708	PHOSPHORYLATION	5024703	PAFLSSLtLELFSRQ	MAD	intracellular localization				5007907	1	1	0		
ARHGEF2 iso2	Guanine nucleotide exchange factor, Rac/Rho; Motility/polarity/chemotaxis	Q92974-2	9181	ARHGEF2	1q21-q22	human	S885	PHOSPHORYLATION	451365	PVDPRRRsLPAGDAL		molecular association, regulation; activity, inhibited	cytoskeletal reorganization	14-3-3 zeta(INDUCES)		22463911	7	19	130	represses RhoA-dependent stress fiber formation	
NUSAP1	Cell cycle regulation	Q9BXS6	51203	NUSAP1	15q15.1	human	T338	PHOSPHORYLATION	3211263	GNSAAVItPFKLTTE		molecular association, regulation; intracellular localization	cytoskeletal reorganization			22723906	1	6	2	inhibits NUSAP binding to microtubules in mitosis	
CASK	Adaptor/scaffold; EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, CAMK; Protein kinase, Ser/Thr (non-receptor)	O70589	12361	Cask		mouse	S395	PHOSPHORYLATION	1261102	DKINTKSsPQIRNPP	L27	molecular association, regulation; intracellular localization		liprin alpha 1(DISRUPTS)		1172872	1	1	0	promotes CASK recruitment to presynaptic membranes and interaction with presynaptic proteins (Veli, Mint1, neurexins, N-type voltage-gated calcium channels);  ;   promotes calcium influx into neurons;  promotes synaptogenesis	
MEKK3	EC 2.7.11.25; KINASE; Kinase, protein; Protein kinase, STE; Protein kinase, Ser/Thr (non-receptor)	Q61084	26406	Map3k3		mouse	S166	PHOSPHORYLATION	3188100	EPRSRHLsVSSQNPG		enzymatic activity, inhibited				8638	2	16	24		
TXA2-R	GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR	P21731	6915	TBXA2R	19p13.3	human	S331	PHOSPHORYLATION	470029	STRPRSLsLQPQLTQ		receptor desensitization, altered				8856	2	4	0		
myelin P0	Adaptor/scaffold; Membrane protein, integral	P25189	4359	MPZ	1q23.3	human	S233	PHOSPHORYLATION	458933	SRSTKAVsEKKAKGL	Protocadherin; Myelin-PO_C	intracellular localization				7640	4	1	0		
P130Cas	Adaptor/scaffold; Motility/polarity/chemotaxis	Q61140	12927	Bcar1		mouse	Y169	PHOSPHORYLATION	448722	PSPATDLyQVPPGPG			cell motility, altered			15331022	7	0	0	SH3 and CCH domains are required for P130Cas tyrosine phosphorylation and promoting cell migration.   	
RAF1	EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, Ser/Thr (non-receptor); Protein kinase, TKL	P04049	5894	RAF1	3p25	human	S233	PHOSPHORYLATION	448651	VSSQHRYsTPHAFTF		molecular association, regulation		14-3-3 beta(INDUCES); HRas(DISRUPTS)		6879	2	2	2		
RXRA	DNA binding protein; Motility/polarity/chemotaxis; Nuclear receptor	P19793	6256	RXRA	9q34.3	human	Y249	PHOSPHORYLATION	456812	VEPKTETyVEANMGL		activity, inhibited	transcription, inhibited; transcription, altered			14081213; 6890	2	0	0		
CD28	Cell surface; Membrane protein, integral	P10747	940	CD28	2q33	human	Y191	PHOSPHORYLATION	450282	SRLLHSDyMNMTPRR		molecular association, regulation		GADS(INDUCES)		8327	5	4	314		
SATB1	DNA binding protein; Transcription factor	Q01826	6304	SATB1	3p23	human	T188	PHOSPHORYLATION	13906400	PEQWSHTtVRNALKD		sumoylation; molecular association, regulation; intracellular localization		PIAS1(DISRUPTS)		13326318	1	0	0		
STIM1	Calcium-binding protein; Endoplasmic reticulum; Membrane protein, integral	Q13586	6786	STIM1	11p15.5	human	S486	PHOSPHORYLATION	11485308	DMDEEIVsPLSMQSP		activity, inhibited				11419346	1	0	0	involved in suppression of store-operated calcium entry during mitosis	
TTK	Cancer Testis Antigen (CTA); EC 2.7.12.1; KINASE; Kinase, protein; Protein kinase, Other; Protein kinase, dual-specificity	P33981	7272	TTK	6q13-q21	human	T676	PHOSPHORYLATION	487540	NQMQPDTtSVVKDSQ	Pkinase	molecular association, regulation; enzymatic activity, induced	cell cycle regulation	TTK(NOT_REPORTED)		4042509; 1713135; 2831759	7	2	0		
HSP27	Chaperone; Motility/polarity/chemotaxis	Q00649		HSPB1		chicken	S15	PHOSPHORYLATION	448401	FTFLTSPsWEPFRDW		protein conformation				8559	33	40	27	Mutations mimicking phosphorylation of sites single (S15D) and in combination  form high and low molecular oligomers and affect chaperone activity in vitro. 	
PIP5K1C	Carbohydrate Metabolism - inositol phosphate; EC 2.7.1.68; Kinase, lipid; Motility/polarity/chemotaxis	O60331	23396	PIP5K1C	19p13.3	human	S650	PHOSPHORYLATION	457599	DERSWVYsPLHYSAQ		molecular association, regulation; intracellular localization; phosphorylation	cytoskeletal reorganization; cell adhesion, altered	talin 1(DISRUPTS)		7127	2	2	0	inhibits phosphorylation at PIP5KG at Y649	
DYN1	EC 3.6.5.5; Hydrolase; Microtubule binding protein; Motility/polarity/chemotaxis; Motor protein; Vesicle protein	P21575	140694	Dnm1		rat	Y597	PHOSPHORYLATION	447606	NTEQRNVyKDYRQLE	PH	molecular association, regulation; receptor internalization, altered; protein conformation; activity, inhibited				2461; 1058	3	0	0	Y231/597F mutant Inhibits B2-AR internalization, and inhibited the isoproterenol mediated activation of ERK2.; Tyrosine phosphorylation promotes DYN1 self assembly.	
MAX iso2	DNA binding protein; Transcription factor	P61244-2	4149	MAX	14q23	human	S2	PHOSPHORYLATION	449307	______MsDNDDIEV	DUF342	activity, inhibited	transcription, altered			9408	4	12	0	phosphorylation-deficient mutant inhibits transcription more efficiently	
ADORA3	GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR	P28647	25370	Adora3		rat	T319	PHOSPHORYLATION	450330	DSNLEQTtE______		receptor desensitization, altered				3050	1	0	0		
FLT3	EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Protein kinase, TK; Protein kinase, tyrosine (receptor)	Q00342	14255	Flt3		mouse	Y845	PHOSPHORYLATION	454872	DILSDSSyVVRGNAR	Pkinase_Tyr	protein stabilization; enzymatic activity, induced				6717	5	1	76		
Ebp1	Nuclear receptor co-regulator; Transcription, coactivator/corepressor	Q9UQ80	5036	PA2G4	12q13.2	human	S363	PHOSPHORYLATION	981405	ALLQSSAsRKTQKKK	TraC	molecular association, regulation; intracellular localization	transcription, inhibited; cell growth, altered	SIN3A(INDUCES); HDAC2(INDUCES)		970011	1	1	0	nuclear localization	
VCP	Chaperone; DNA repair; Endoplasmic reticulum; Hydrolase	P55072	7415	VCP	9p13.3	human	S746	PHOSPHORYLATION	457557	AMRFARRsVSDNDIR	DNA_ligase_A_C; Vps4_C		apoptosis, inhibited			7785	2	3	1		
PAG	Adaptor/scaffold; Membrane protein, integral	Q9JM80	64019	Pag1		rat	Y409	PHOSPHORYLATION	448996	LVPKENDyESIGDLQ		intracellular localization	cytoskeletal reorganization; cell growth, altered			6277005; 4338204	3	20	657		
SGK1	EC 2.7.11.1; KINASE; Kinase, protein; Motility/polarity/chemotaxis; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor)	O00141	6446	SGK1	6q23	human	T256	PHOSPHORYLATION	448431	EHNSTTStFCGTPEY	Pkinase	enzymatic activity, induced	apoptosis, inhibited			1269; 1267; 4313604; 5309414	12	0	0	HSP90 is required for SGK kinase activity.; adhesion dependent activation 	
DYRK2	EC 2.7.12.1; KINASE; Kinase, protein; Protein kinase, CMGC; Protein kinase, dual-specificity	Q92630	8445	DYRK2	12q15	human	T106	PHOSPHORYLATION	11489910	NKRTVLTtQPNGLTT		protein stabilization; molecular association, regulation; intracellular localization		MDM2(DISRUPTS)		11387204	1	0	0		
SH3PXD2B	Lipid binding protein	A1X283	285590	SH3PXD2B	5q35.1	human	Y508	PHOSPHORYLATION	17303901	DMSASAGyEEISDPD		molecular association, regulation	carcinogenesis, altered; cytoskeletal reorganization	NOXA1(INDUCES)		15755103	1	0	0		
TTK	Cancer Testis Antigen (CTA); EC 2.7.12.1; KINASE; Kinase, protein; Protein kinase, Other; Protein kinase, dual-specificity	P33981	7272	TTK	6q13-q21	human	S281	PHOSPHORYLATION	1737603	VPVNLLNsPDCDVKT		protein stabilization; ubiquitination	carcinogenesis, induced; cytoskeletal reorganization	Cdc27(DISRUPTS)		25082843	1	14	1	accumulation at centrosomes, aneuploidy, correlated with p-ERK, in human metastatic melanoma; centrosome reduplication	
STAT5A	DNA binding protein; Motility/polarity/chemotaxis; Transcription factor	P42230	20850	Stat5a		mouse	S779	PHOSPHORYLATION	448750	DSLDARLsPPAGLFT		activity, induced; molecular association, regulation	carcinogenesis, altered; transcription, induced	HER4(INDUCES)		14551412; 2198; 6895	9	9	0		
PDK1	EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor)	O15530	5170	PDPK1	16p13.3	human	T354	PHOSPHORYLATION	25256100	WENLHQQtPPKLTAY		molecular association, regulation; enzymatic activity, inhibited	apoptosis, altered; cell growth, inhibited; signaling pathway regulation	14-3-3 beta(INDUCES); STRAP(DISRUPTS)		25227664	1	0	0	alleviates PDK1-mediated supression of apoptosis	
CD45	EC 3.1.3.48; Membrane protein, integral; Motility/polarity/chemotaxis; PHOSPHATASE; Receptor protein phosphatase, tyrosine	P06800	19264	Ptprc		mouse	S988	PHOSPHORYLATION	449972	SKESEPEsDESSDDD	Y_phosphatase	enzymatic activity, induced				2533	1	1	0		
TrkA	EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Protein kinase, TK; Protein kinase, tyrosine (receptor)	P04629	4914	NTRK1	1q21-q22	human	Y496	PHOSPHORYLATION	447762	HIIENPQyFSDACVH		molecular association, regulation; receptor internalization, altered; enzymatic activity, induced	cell differentiation, altered; apoptosis, induced; cell growth, altered	Shc1 iso2(INDUCES); Shc1(INDUCES); FRS2(INDUCES)		8513; 7184; 5955614; 8868; 799; 5955616	17	0	2		
MC1R	GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR	Q01726	4157	MC1R	16q24.3	human	T308	PHOSPHORYLATION	471419	HSQELRRtLKEVLTC		receptor internalization, altered				9118	1	0	0	T308 and S316 phosphorylation regulate MC1R internalization and desensitization. 	
Syk	EC 2.7.10.2; KINASE; Kinase, protein; Protein kinase, TK; Protein kinase, tyrosine (non-receptor)	P43405	6850	SYK	9q22	human	Y348	PHOSPHORYLATION	447659	LPMDTEVyESPYADP		molecular association, regulation; enzymatic activity, induced		PLCG1(INDUCES); ITGAM(INDUCES)		6782010; 759	9	7	114	ITAM peptide binding increases autophosphorylation of Syk.	
Kv1.1	Channel, potassium; Membrane protein, integral; Membrane protein, multi-pass	P10499	24520	Kcna1		rat	S446	PHOSPHORYLATION	451079	SDLSRRSsSTISKSE		activity, induced				3297	2	0	0	Reduces the extent of inactivation of the channel	
perilipin	Lipid binding protein	Q8CGN5	103968	Plin1		mouse	S517	PHOSPHORYLATION	471365	YSQLRKKs_______		activity, induced; molecular association, regulation		ABHD5(DISRUPTS)		11189917; 9106	6	0	1	stimulates perilipin-mediated lipolysis in adipocytes; induces dissociation of ABHD5 from perilipin and its association with Atgl	
MDM4	EC 6.3.2.-; Ligase; UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase	O15151	4194	MDM4	1q32	human	Y99	PHOSPHORYLATION	6039500	VKDPSPLyDMLRKNL	SWIB	molecular association, regulation; phosphorylation		p53(DISRUPTS)		5930028	1	1	0	affects Y55 phosphorylation 	
TYMS	Cofactor and Vitamin Metabolism - one carbon pool by folate; DNA repair; EC 2.1.1.45; Methyltransferase; Mitochondrial; Nucleotide Metabolism - pyrimidine	P04818	7298	TYMS	18p11.32	human	S124	PHOSPHORYLATION	13209303	FLDSLGFsTREEGDL	Thymidylat_synt	enzymatic activity, inhibited; protein conformation				14081221	2	1	0	molecular modeling studies	
LC3A	Autophagy; Microtubule binding protein; Ubiquitin-like modifier; Vesicle protein	Q9H492	84557	MAP1LC3A	20q11.22	human	S12	PHOSPHORYLATION	15116600	RPFKQRRsFADRCKE		intracellular localization	autophagy, altered			15022706	1	1	0		
PPP2CA	EC 3.1.3.16; Motility/polarity/chemotaxis; PHOSPHATASE; Protein phosphatase, Ser/Thr (non-receptor)	P67775	5515	PPP2CA	5q31.1	human	T304	PHOSPHORYLATION	450083	EPHVTRRtPDYFL__		molecular association, regulation; enzymatic activity, inhibited	cytoskeletal reorganization; cell growth, altered	PPP2R5A(DISRUPTS); PPP2R5D(INDUCES); PPP2R3A(INDUCES); PPP2R2A(NOT_REPORTED)		9407; 2662	3	6	2	Done with T304A and T304D mutations as compared to WT.  Not reported means both mutation effected binding in the same way.	
PKCD	EC 2.7.10.2; EC 2.7.11.13; KINASE; Kinase, protein; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor)	P28867	18753	Prkcd		mouse	Y565	PHOSPHORYLATION	447576	IRVDTPHyPRWITKE	Pkinase	enzymatic activity, inhibited	carcinogenesis, inhibited			1171	4	0	0		
CACNA1C	Channel, calcium; Membrane protein, integral; Membrane protein, multi-pass	BAA34185.2		CACNA1C		guinea pig	T1603	PHOSPHORYLATION	7437803	RTALRIKtEGNLEQA		activity, induced		calmodulin(INDUCES)		7324310	1	0	0		
GCET2	Unknown function	Q8N6F7	257144	GCSAM	3q13.2	human	Y107	PHOSPHORYLATION	454098	GNSAEEYyENVPCKA		molecular association, regulation		Grb2(NOT_REPORTED)		12175	1	2	55		
SH3BP2	Adaptor/scaffold	P78314	6452	SH3BP2	4p16.3	human	S278	PHOSPHORYLATION	455470	PATPRRMsDPPLSTM		molecular association, regulation		14-3-3 theta(INDUCES)		5370	1	4	1		
p70S6K iso2	EC 2.7.11.-; EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor); Translation	P23443-2	6198	RPS6KB1	17q23.1	human	T229	PHOSPHORYLATION	448606	HDGTVTHtFCGTIEY	Pkinase	enzymatic activity, induced				4248207	27	3	8		
ASIC3	Channel, cation; Membrane protein, integral; Membrane protein, multi-pass	O35240	286920	Accn3		rat	T40	PHOSPHORYLATION	12518704	IFGPGGLtLRRGLWA	TM; ASC	activity, induced				12482279	1	0	0	channel activation	
CACNG2	Channel, calcium; Membrane protein, integral; Membrane protein, multi-pass	O88602	12300	Cacng2		mouse	S249	PHOSPHORYLATION	455320	RSTEPSHsRDASPVG	Tetraspannin	activity, induced; intracellular localization				22913905; 4485	1	2	1	AMPAR immobilization in synaptic membrane; enhances AMPA receptor responses and is required for long-term potentiation	
PRPF3	RNA processing; RNA splicing; Spliceosome	O43395	9129	PRPF3	1q21.1	human	T494	PHOSPHORYLATION	999610	TEAVQDPtKVEAHVR	PRP3	molecular association, regulation; protein conformation	cell growth, altered	PRP6(INDUCES); PRPF4(INDUCES)	RNA(INDUCES)	970040	1	0	0	T494M mutation weakens self association and association with PRPF4, PRP6, and U4 and U6 snRNAs.	
FBX43	Unknown function	Q4G163	286151	FBXO43	8q22.2	human	T234	PHOSPHORYLATION	13419500	FSQQKTStIDDSKDD		protein degradation; molecular association, regulation		PLK1(INDUCES)		12482272	1	0	0		
Notch 1	Membrane protein, integral; Motility/polarity/chemotaxis; Receptor, misc.; Transcription factor	Q01705	18128	Notch1		mouse	K1935	ACETYLATION	18899511	YSRSDAAkRLLEASA	Ank_2	protein stabilization; ubiquitination				18899000	1	1	0		
PSRC1	Tumor suppressor	Q6PGN9	84722	PSRC1	1p13.3	human	S65	PHOSPHORYLATION	12667967	APQGVRLsLGPLSPE			cytoskeletal reorganization			18898704	1	6	0		
HSF1	DNA binding protein; Transcription factor	Q00613	3297	HSF1	8q24.3	human	S121	PHOSPHORYLATION	455480	NIKRKVTsVSTLKSE	HSF_DNA-bind; DUF247; DUF2365	molecular association, regulation; activity, inhibited		HSP90A(INDUCES)		7309	2	2	1		
EGFR	EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Protein kinase, TK; Protein kinase, tyrosine (receptor)	P00533	1956	EGFR	7p12	human	Y1110	PHOSPHORYLATION	448058	GSVQNPVyHNQPLNP		molecular association, regulation; ubiquitination; intracellular localization; receptor internalization, altered; protein conformation; enzymatic activity, induced	cell motility, induced; transcription, altered	Cbl(INDUCES); RASA1(INDUCES); Dok2(INDUCES); Dok1(INDUCES); STAT3(INDUCES)	DNA(INDUCES)	2981; 2651; 30280005; 7071; 2852619; 4260; 4843014; 7309801; 2309	34	21	416	 increase of RhoA and Cdc42 activity, motility, migration, and invasion; EGFR  autophosphorylation sites modulate STAT activation. 	
PAR1	Cell development/differentiation; GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR	P25116	2149	F2R	5q13	human	Y383	PHOSPHORYLATION	451198	SECQRYVySILCCKE		protein degradation; receptor internalization, altered				3404	1	0	5		
gephyrin	Adaptor/scaffold; EC 2.10.1.1; EC 2.7.7.75	Q8BUV3	268566	Gphn		mouse	S188	PHOSPHORYLATION	478376	DELEDLPsPPPPLSP		molecular association, regulation		Pin1(INDUCES)		9631	3	21	1		
LRP1	Cell surface; Membrane protein, integral; Motility/polarity/chemotaxis; Receptor, misc.	Q91ZX7	16971	Lrp1		mouse	Y4508	PHOSPHORYLATION	451245	TNFTNPVyATLYMGG			cell cycle regulation			15278809	5	2	0		
p21Cip1	Cell cycle regulation; Inhibitor protein	P38936	1026	CDKN1A	6p21.2	human	T145	PHOSPHORYLATION	447837	QGRKRRQtSMTDFYH		protein stabilization; molecular association, regulation; intracellular localization	cell cycle regulation; cell growth, inhibited	Akt2(DISRUPTS); CDK4(DISRUPTS); CDK2(DISRUPTS); PCNA(DISRUPTS)		5956; 4771; 7232; 2624100; 22913903; 1202; 3361011; 6242	15	0	0	Pim-2-stabilized p21 localizes in the nucleus.; Binding of p21Cip1 to cyclin A is not dependent on T144 phosphorylation in vitro.	
EXO1	EC 3.1.-.-; Hydrolase	Q9UQ84	9156	EXO1	1q42-q43	human	T621	PHOSPHORYLATION	1240808	GLGDFSRtPSPSPST		protein degradation				1223901	1	1	0		
PXN	Adaptor/scaffold; Cell adhesion; Cytoskeletal protein; Motility/polarity/chemotaxis	Q8VI36	19303	Pxn		mouse	Y88	PHOSPHORYLATION	448909	PPSPLPVySSSAKNS	Paxillin		carcinogenesis, induced; cell growth, altered			12525221	3	31	1366		
PPP1R3A	Membrane protein, integral; Protein phosphatase, regulatory subunit	Q00756	100009140	RG1		rabbit	S48	PHOSPHORYLATION	449320	PQPSRRGsESSEEVY		enzymatic activity, induced				1480	5	3	0		
FRA1	DNA binding protein; Transcription factor	P15407	8061	FOSL1	11q13	human	T223	PHOSPHORYLATION	1270901	HTPTLMTtPSLTPFT		protein stabilization				9581	2	0	0		
DAB1 iso2	Adaptor/scaffold	P97318-2	13131	Dab1		mouse	S515	PHOSPHORYLATION	479423	IFEEGFEsPSKSEEQ		phosphorylation				11449	1	0	0	inhibits tyrosine phosphorylation	
IRF5	DNA binding protein; Transcription factor	Q13568	3663	IRF5	7q32	human	S440	PHOSPHORYLATION	455995	ELSWSADsIRLQISN		activity, induced; molecular association, regulation	transcription, induced	CBP(INDUCES)		25779418; 6568	2	0	0		
KIF23	Microtubule binding protein; Motility/polarity/chemotaxis; Motor protein	E9Q5G3	71819	Kif23		mouse	S905	PHOSPHORYLATION	459841	GSRKRRSsTLAPAQP		intracellular localization	cell cycle regulation; cytoskeletal reorganization			8646	1	8	258	regulates cytokinesis	
AQP2	Channel, misc.; Membrane protein, integral; Membrane protein, multi-pass	P34080	25386	Aqp2		rat	S261	PHOSPHORYLATION	464644	RQSVELHsPQSLPRG		molecular association, regulation		GRP78(DISRUPTS); GDI2(DISRUPTS); HSP70(DISRUPTS); RAN(DISRUPTS); HSC70(DISRUPTS); ANXA2(DISRUPTS); PPP1CA(DISRUPTS)		6829231	15	7	0		
CRY1	DNA binding protein; Lyase; Transcription, coactivator/corepressor	P97784	12952	Cry1		mouse	S71	PHOSPHORYLATION	11952908	ANLRKLNsRLFVIRG	DNA_photolyase	protein degradation; molecular association, regulation		Per2(DISRUPTS); FBXL3(INDUCES)		11419372	1	0	0		
TRPV1	Channel, cation; Membrane protein, integral; Membrane protein, multi-pass; Receptor, misc.	Q8NER1	7442	TRPV1	17p13.2	human	S502	PHOSPHORYLATION	450016	YFLQRRPsMKTLFVD		receptor desensitization, altered; intracellular localization				4049522	14	0	0		
TH	Amino Acid Metabolism - tyrosine; EC 1.14.16.2; Endoplasmic reticulum; Mitochondrial; Oxidoreductase; Vesicle protein	P07101	7054	TH	11p15.5	human	S19	PHOSPHORYLATION	448542	KGFRRAVsELDAKQA	TOH_N	enzymatic activity, induced				7846	33	4	3	enzymatic activity increases in the absence of serum, but decreases after addition of GDNF 	
S6	Translation	P62754	20104	Rps6		mouse	S240	PHOSPHORYLATION	448094	RLSSLRAsTSKSESS			carcinogenesis, induced			27519661	53	33	836	Increased Kras induced pancreatic lesions, metaplastic foci, p53 expression	
PIK3CD	Carbohydrate Metabolism - inositol phosphate; EC 2.7.1.153; KINASE; Kinase, lipid; Motility/polarity/chemotaxis	O00329	5293	PIK3CD	1p36.2	human	S1039	PHOSPHORYLATION	466429	NWLAHNVsKDNRQ__		enzymatic activity, inhibited				8193	2	3	0		
GUCY1A3	EC 4.6.1.2; Guanylyl cyclase; Lyase; Nucleotide Metabolism - purine; Receptor, misc.	Q8CJD2	497757	Gucy1a3		rat	S107	PHOSPHORYLATION	450954	KIKENRNsSEKEDLE	HNOB	enzymatic activity, induced				3227	1	0	0		
PKCE	EC 2.7.11.13; KINASE; Kinase, protein; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor)	P16054	18754	Prkce		mouse	T566	PHOSPHORYLATION	448787	MNGVTTTtFCGTPDY	Pkinase	enzymatic activity, induced				2207	6	1	0		
GEM	G protein; G protein, monomeric, RGK	P55040	2669	GEM	8q13-q21	human	S261	PHOSPHORYLATION	450647	AYQKRKEsMPRKARR		molecular association, regulation; intracellular localization	cytoskeletal reorganization	KPNA5(DISRUPTS)		1172801; 3061	2	0	0	interaction abolished in triple phosphomimetic mutant S261/287/289D; Cell flattening and neurite extension; interaction increased in S261 alanine mutant	
IREM-1	Immunoglobulin superfamily; Membrane protein, integral; Receptor, misc.	Q8TDQ1	146722	CD300LF	17q25.1	human	Y249	PHOSPHORYLATION	474546	LPKEDISyASLTLGA		activity, induced; molecular association, regulation		SHP-1(INDUCES)		9304	1	0	0	mutation of site to Phe decreased the inhibitory activity of IREM-1	
PRMT5	Cell cycle regulation; EC 2.1.1.-; EC 2.1.1.125; METHYLTRANSFERASE; Methyltransferase; Methyltransferase, protein arginine; RNA processing	O14744	10419	PRMT5	14q11.2	human	Y304	PHOSPHORYLATION	18545701	YELFAKGyEDYLQSP	PRMT5	molecular association, regulation; enzymatic activity, inhibited	carcinogenesis, altered; cell growth, altered	PRMT5(DISRUPTS)		18410835	1	0	0	contributes to the mutant Jak2 V617F -induced myeloproliferative phenotype; negatively regulates hematopoietic stem/progenitor cell expansion and erythroid differentiation	
Chk1	EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, CAMK; Protein kinase, Ser/Thr (non-receptor)	O14757	1111	CHEK1	11q24.2	human	S345	PHOSPHORYLATION	447834	LVQGISFsQPTCPDH		protein degradation; molecular association, regulation; intracellular localization; enzymatic activity, induced	cell cycle regulation; apoptosis, altered	14-3-3 sigma(INDUCES); p53(INDUCES); claspin(INDUCES); p21Cip1(INDUCES)		6137; 3232; 15331018; 636; 6842207; 5407; 635; 6921; 7214800; 4600; 5011209	99	0	11		
p90RSK	EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor); Translation	P18652	386579	RPS6KA1		chicken	S398	PHOSPHORYLATION	447990	HQLFRGFsFVATGLM	Pkinase_C	molecular association, regulation; intracellular localization; enzymatic activity, induced		PDK1(INDUCES)		6556	45	26	62		
TrkB	EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Protein kinase, TK; Protein kinase, tyrosine (receptor)	Q63604	25054	Ntrk2		rat	Y816	PHOSPHORYLATION	451754	LAKASPVyLDILG__		molecular association, regulation	translation, altered	Cbl(INDUCES); PLCG1(INDUCES)		10199100	6	0	0	c-fos protein synthesis induced by BDNF	
Rb	Nuclear receptor co-regulator; Transcription, coactivator/corepressor; Tumor suppressor	P06400	5925	RB1	13q14.2	human	S249	PHOSPHORYLATION	447975	AVIPINGsPRTPRRG			cell cycle regulation			4214807	12	20	69		
mAChR M2	GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR	P08172	1129	CHRM2	7q31-q35	human	T307	PHOSPHORYLATION	459106	EITQDENtVSTSLGH	7tm_1	receptor desensitization, altered; receptor internalization, altered				7628	3	0	0	Mutation of 4 S/T to A eliminates receptor desensitization in response to carbachol treatment (as measured by isoproterenol-stimulated cAMP production after pretreatment with carbachol).; Mutation of S286 T287 S288 S290 to A caused a faster rate and a greater extent of receptor internalization after agonist stimulation (transients only, not observed in stables).  Mutation of all 8 sites prevented internalization (in both transients and stables).	
ERK5	EC 2.7.11.24; KINASE; Kinase, protein; Protein kinase, CMGC; Protein kinase, Ser/Thr (non-receptor)	Q13164	5598	MAPK7	17p11.2	human	T733	PHOSPHORYLATION	455520	LPPVFSGtPKGSGAG		intracellular localization; enzymatic activity, inhibited	transcription, altered			19084403	3	7	1		
p53	Activator protein; DNA binding protein; Motility/polarity/chemotaxis; Nuclear receptor co-regulator; Transcription factor; Tumor suppressor	P02340	22059	Tp53		mouse	S34	PHOSPHORYLATION	447532	PPEDILPsPHCMDDL		phosphorylation				8707	64	3	0	S37A mutant abrogates the constitutive phosphorylation at S18 (S15 in human) in the BVE system, but not in the mamalian in vitro expression system	
PINX1	Inhibitor protein	Q96BK5	54984	PINX1	8p23	human	S110	PHOSPHORYLATION	14823406	SDKKEKKsFSLEEKS		protein degradation; ubiquitination				14790317	1	1	0		
VEGFR2	EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Protein kinase, TK; Protein kinase, tyrosine (receptor)	P35968	3791	KDR	4q11-q12	human	Y1214	PHOSPHORYLATION	447902	VCDPKFHyDNTAGIS		molecular association, regulation; enzymatic activity, induced	cell motility, altered; cytoskeletal reorganization	Nck1(INDUCES); Fyn(INDUCES)		13852009; 2624803; 4802	12	4	58		
Akt1	EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor)	P31749	207	AKT1	14q32.32	human	T312	O-GlcNAc	25538003	TMKTFCGtPEYLAPE	Pkinase	enzymatic activity, inhibited; phosphorylation				25347053	1	1	0	suppresses Akt phosphorylation at T308 by disrupting its interaction with PDK1	
NCoA2	Motility/polarity/chemotaxis; Transcription, coactivator/corepressor	Q15596	10499	NCOA2	8q13.3	human	S487	PHOSPHORYLATION	4728845	GQPTSMLsPRHRMSP			transcription, induced			22723912	1	5	1		
CAPZA1	Actin binding protein; Motility/polarity/chemotaxis	P52907	829	CAPZA1	1p13.2	human	S9	PHOSPHORYLATION	457555	ADFDDRVsDEEKVRI		molecular association, regulation; phosphorylation	cytoskeletal reorganization	PLEKHO1(INDUCES)		7103	1	5	0		
talin 1	Cytoskeletal protein; Motility/polarity/chemotaxis	Q9Y490	7094	TLN1	9p13	human	S425	PHOSPHORYLATION	1984203	TMLEDSVsPKKSTVL		protein stabilization; molecular association, regulation; ubiquitination	cell motility, altered; cell adhesion, altered	SMURF1(DISRUPTS)		7659803	1	16	2		
sialophorin	Cell surface; Membrane protein, integral	P15702	20737	Spn		mouse	S347	PHOSPHORYLATION	477870	RRKSRQGsLVLEELK		intracellular localization	cell motility, altered			18410802; 12071	2	17	66	required for T cell trafficking to the lymph nodes; interaction with ezrin, radixin, moesin inhibits T cell migration	
NRF2	DNA binding protein; Transcription factor	Q60795	18024	Nfe2l2		mouse	S351	PHOSPHORYLATION	18258500	SRASPEHsVESSIYG		protein degradation; molecular association, regulation		BTRC(INDUCES)		18021029	1	0	0		
AVPR2	GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR	P30518	554	AVPR2	Xq28	human	S362	PHOSPHORYLATION	451067	DESCTTAsSSLAKDT		intracellular localization				3288	1	0	0	After receptor activation, phosphorylation of serines  362, 363, and 364 inhibits overall dephosphorylation of the internalized receptor, thereby inhibiting recycling of the receptor to the cell surface.	
MafA	DNA binding protein; Transcription factor	O57342		MAFA		quail	T113	PHOSPHORYLATION	456029	NPEALNLtPEDAVEA	Maf_N		cell differentiation, altered; transcription, altered			6333	3	2	0		
FLOT2	Cell adhesion	Q9Z2S9	83764	Flot2		rat	Y124	PHOSPHORYLATION	1270904	TLTVEQIyQDRDQFA	Band_7		cell motility, altered; cytoskeletal reorganization			9297	1	0	0		
MEK1	EC 2.7.12.2; KINASE; Kinase, protein; Protein kinase, STE; Protein kinase, dual-specificity	P31938	26395	Map2k1		mouse	S218	PHOSPHORYLATION	448514	VSGQLIDsMANSFVG	Pkinase	molecular association, regulation; enzymatic activity, induced	cell growth, altered	ERK1(INDUCES)		6759; 1800; 1740; 4914026	90	5	54		
TAX1BP1 iso2	Apoptosis	Q86VP1-2	8887	TAX1BP1	7p15	human	S593	PHOSPHORYLATION	12738639	NYKELKRsLENPAER		molecular association, regulation; ubiquitination	signaling pathway regulation	TRAF2(INDUCES); TRAF6(INDUCES)		20722937	1	2	0	regulates NF-kB signaling;  ;  regulates interaction with A20 and Itch via TRAF2 and TRAF6	
mucolipin 1	Channel, cation; Membrane protein, integral; Membrane protein, multi-pass	Q9GZU1	57192	MCOLN1	19p13.2	human	S557	PHOSPHORYLATION	1233701	SGKFRRGsGSACSLL		activity, inhibited				1172824	1	6	0		
SIRT1	Apoptosis; DEACETYLASE; Deacetylase; EC 3.5.1.-; Nuclear receptor co-regulator	Q923E4	93759	Sirt1		mouse	S683	PHOSPHORYLATION	9993600	EEPLEDEsEIEEFYN		enzymatic activity, induced	apoptosis, inhibited			9980406	1	0	0	deacetylates p53 K382 and NFkB-p65	
TNNI3	Actin binding protein; Motility/polarity/chemotaxis; Motor protein	P48787	21954	Tnni3		mouse	S24	PHOSPHORYLATION	448424	APVRRRSsANYRAYA	Troponin-I_N	activity, induced; protein conformation; activity, inhibited; phosphorylation	cytoskeletal reorganization			13320406; 7134; 3342610; 854; 4862629; 8954; 4423	33	4	16		
NR0B2	Nuclear receptor co-regulator; Transcription, coactivator/corepressor	Q62227	23957	Nr0b2		mouse	K122	UBIQUITINATION	7596701	APVPSILkKILLEEA	Hormone_recep	protein degradation				7543519	1	0	0		
FOXO1A	DNA binding protein; Nuclear receptor co-regulator; Transcription factor	Q12778	2308	FOXO1	13q14.1	human	S287	PHOSPHORYLATION	478910	GQEGAGDsPGSQFSK		intracellular localization	transcription, altered			12525214	4	11	1	multiple site mutant (8A)	
galectin-3	Cell surface; Extracellular matrix; Motility/polarity/chemotaxis	P17931	3958	LGALS3	14q22.3	human	Y79	PHOSPHORYLATION	13213701	GAPAPGVyPGPPSGP		protein stabilization	carcinogenesis, induced; apoptosis, altered			13164205	2	1	0		
Ret iso3	EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Protein kinase, TK; Protein kinase, tyrosine (receptor)	Q15300	5979	RET	10q11.2	human	Y586	PHOSPHORYLATION	447625	TWIENKLyGRISHAF		molecular association, regulation		Shc1(INDUCES)		2779	36	0	2		
WAVE2	Actin binding protein; Motility/polarity/chemotaxis	Q9Y6W5	10163	WASF2	1p36.11	human	S489	PHOSPHORYLATION	6377640	SDSEDDSsEFDEDDW		activity, inhibited	cytoskeletal reorganization			6337810	1	0	1		
EGFR	EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Protein kinase, TK; Protein kinase, tyrosine (receptor)	Q01279	13649	Egfr		mouse	Y1092	PHOSPHORYLATION	448057	AFLPVPEyVNQSVPK			apoptosis, inhibited			6784	84	16	326		
PIK3R1	Enzyme, regulatory subunit; KINASE; Kinase, lipid; Motility/polarity/chemotaxis	P27986	5295	PIK3R1	5q13.1	human	Y556	PHOSPHORYLATION	459303	LKKQAAEyREIDKRM	IncA; DUF1338	molecular association, regulation; enzymatic activity, induced	cell motility, altered	SHP-2(INDUCES); IRS1(INDUCES)		7747	1	3	26		
claudin 5	Cytoskeletal protein; Membrane protein, integral; Membrane protein, multi-pass	O54942	12741	Cldn5		mouse	T207	PHOSPHORYLATION	454390	YSAPRRPtANGDYDK		activity, induced	cytoskeletal reorganization			4263	3	1	9		
Rb-like 2	Transcription, coactivator/corepressor	Q08999	5934	RBL2	16q12.2	human	T694	PHOSPHORYLATION	449730	DSPSDGGtPGRMPPQ		molecular association, regulation	cell cycle regulation	E2F4(DISRUPTS)		1200	3	1	1		
PML iso4	Transcription factor; Tumor suppressor; Ubiquitin conjugating system	P29590-4	5371	PML	15q22	human	S530	PHOSPHORYLATION	451473	DGPPSPRsPVIGSEV	DUF3583	protein stabilization	apoptosis, altered			3657	2	7	7	Phosphorylation of PML is associated with enhanced sumoylation and apoptosis induced by As2O3. 	
Snail1	C2H2-type zinc finger protein; Transcription factor	O95863	6615	SNAI1	20q13.2	human	T203	PHOSPHORYLATION	21400402	QGHVRTHtGEKPFSC	zf-H2C2_2	protein stabilization; intracellular localization	cell cycle regulation; carcinogenesis, induced; cell motility, altered			21385521	1	0	1	contributes to Snail1 retention in the nucleus	
Nur77	Apoptosis; DNA binding protein; Nuclear receptor	P22736	3164	NR4A1	12q13	human	S351	PHOSPHORYLATION	447942	GRRGRLPsKPKQPPD		activity, inhibited; phosphorylation	apoptosis, induced; cytoskeletal reorganization; transcription, inhibited			6213; 2590903	7	2	0	Akt inhibits MEKK1-mediated nuclear export of Nur77 by phosphorylating S351. 	
Gab2	Adaptor/scaffold	Q9UQC2	9846	GAB2	11q14.1	human	Y476	PHOSPHORYLATION	450051	GDNSQSVyIPMSPGA		molecular association, regulation		PIK3R1(INDUCES)		6227	1	1	193		
TFEB	DNA binding protein	Q9R210	21425	Tfeb		mouse	S466	PHOSPHORYLATION	4785142	KASSRRSsFSMEEGD		protein stabilization	transcription, induced			27928005	1	10	1		
NEK2	EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor)	P51955	4751	NEK2	1q32.2-q41	human	S171	PHOSPHORYLATION	12574604	RILNHDTsFAKTFVG	Pkinase	enzymatic activity, induced				12482404	1	1	0		
occludin	Cell adhesion; Membrane protein, integral; Membrane protein, multi-pass; Motility/polarity/chemotaxis	Q16625	100506658	OCLN	5q13.1	human	Y402	PHOSPHORYLATION	458611	QDHYETDyTTGGESC	DUF342; APG6	molecular association, regulation; intracellular localization		ZO1(INDUCES)		5354427	1	4	6		
H3	DNA binding protein	P68431	8350	HIST1H3A	6p22.1	human	K10	METHYLATION	1668801	RTKQTARkSTGGKAP		phosphorylation	chromatin organization, altered		DNA(DISRUPTS)	3342620; 7991110	18	0	0	inibits S10 phosphorylation	
CITED1	Nuclear receptor co-regulator	P97769	12705	Cited1		mouse	S84	PHOSPHORYLATION	27937109	TPSSKPPsFNLHPTP	CITED	intracellular localization	cell differentiation, induced			27780046	1	0	0	S63/64/65/67/69/73/79/80/84A mutation in CITED1 inhibits its translocation into the nucleus and osteoblasts differentiation	
C5aR	GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR	P21730	728	C5AR1	19q13.3-q13.4	human	S327	PHOSPHORYLATION	448821	RNVLTEEsVVRESKS		molecular association, regulation; receptor desensitization, altered		ARRB1(INDUCES); ARRB2(INDUCES)		9155; 1994	4	8	37	induces translocation of beta-arrestin into the plasma membrane	
RasGRF2	Guanine nucleotide exchange factor, Ras	P70392	19418	Rasgrf2		mouse	S737	PHOSPHORYLATION	2902208	LAVSRTSsPVRARKL	RasGEF_N	activity, induced; intracellular localization; phosphorylation				8769	1	0	0	regulates phosphorylation of MEK and ERK	
GYS1	Carbohydrate Metabolism - starch and sucrose; EC 2.4.1.11; Transferase	P13834	100008660	GYS1		rabbit	S653	PHOSPHORYLATION	448240	PSLSRHSsPHQSEDE	Glycogen_syn	enzymatic activity, inhibited				4917204	12	9	1		
GIRK1	Channel, potassium; Membrane protein, integral; Membrane protein, multi-pass	P48549	3760	KCNJ3	2q24.1	human	S385	PHOSPHORYLATION	4706226	NSKERHNsVECLDGL	IRK	activity, induced				6037505	3	4	1		
SREBP-2	DNA binding protein; Membrane protein, integral; Membrane protein, multi-pass; Transcription factor	Q12772	6721	SREBF2	22q13	human	S432	PHOSPHORYLATION	451007	NQNVLLMsPPASDSG			transcription, induced			3258	1	0	0		
PU.1	DNA binding protein; Transcription factor	P17433	20375	Spi1		mouse	S133	PHOSPHORYLATION	478390	SPAHQQSsDEEEGER		molecular association, regulation		IRF8(INDUCES); PU.1(INDUCES); IRF2(INDUCES)		9577	1	0	0	Interaction of PU.1, IRF-2, and IRF-8 requires phosphorylated residues on each protein. 	
BMAL1	DNA binding protein; Transcription factor	Q9WTL8	11865	Arntl		mouse	S97	PHOSPHORYLATION	7359500	RRRDKMNsFIDELAS	HLH	intracellular localization	transcription, altered			7324309	1	0	0	regulates circadian gene expression	
ITGB4	Cell adhesion; Membrane protein, integral; Motility/polarity/chemotaxis; Receptor, misc.	P16144	3691	ITGB4	17q25	human	S1325	PHOSPHORYLATION	3103700	TQPKRPMsIPIIPDI		molecular association, regulation		plectin 1(INDUCES)		8579	1	0	0		
BMF	Apoptosis; Cytoskeletal protein	Q91ZE9	171543	Bmf		mouse	S74	PHOSPHORYLATION	11267001	DKATQTLsPASPSQG		activity, induced	apoptosis, altered			11189915	3	0	0	required for normal lymphocyte homeostasis	
ovalbumin		P01012	396058			chicken	S345	PHOSPHORYLATION	22689701	AGREVVGsAEAGVDA	Serpin	protein stabilization				27981102	1	0	0		
KHSRP	RNA binding protein	Q92945	8570	KHSRP	19p13.3	human	T692	PHOSPHORYLATION	458387	QAAYYGQtPGPGGPQ	DUF1897		RNA stability, altered			7424	1	0	0	inhibits degradation of myogenic transcripts during myoblast differentiation	
CTNNB1	Actin binding protein; Cell adhesion; Motility/polarity/chemotaxis; Nuclear receptor co-regulator; Transcription factor	P35222	1499	CTNNB1	3p21	human	Y670	PHOSPHORYLATION	469563	SEDKPQDyKKRLSVE		activity, induced; molecular association, regulation	cell growth, induced; cell growth, altered	LEF-1(DISRUPTS); Met(DISRUPTS); CDH1(DISRUPTS)		20834136; 8232	2	1	14		
p70S6K	EC 2.7.11.-; EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor); Translation	P67999	83840	Rps6kb1		rat	S40	PHOSPHORYLATION	450117	DQPEDAGsEDELEEG		molecular association, regulation		exportin 1(INDUCES)		8244	2	0	0		
TrkC	EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Protein kinase, TK; Protein kinase, tyrosine (receptor)	Q03351	29613	Ntrk3		rat	Y859	PHOSPHORYLATION	451749	LGKATPIyLDILG__		molecular association, regulation		Shc1(INDUCES); PLCG1(INDUCES)		3827	1	0	0		
CYP19A1	EC 1.14.14.1; Lipid Metabolism - androgen and estrogen; Oxidoreductase	P11511	1588	CYP19A1	15q21.1	human	Y361	PHOSPHORYLATION	10433800	KVMENFIyESMRYQP	p450	enzymatic activity, induced				10425122	1	0	0		
ZNF76	C2H2-type zinc finger protein	P36508	7629	ZNF76	6p21.31	human	K411	SUMOYLATION	2798302	IAYLSEVkEERDDIP		activity, inhibited	transcription, altered			7630	2	0	0		
H3	DNA binding protein	P68431	8350	HIST1H3A	6p22.1	human	K28	ACETYLATION	465521	LATKAARkSAPATGG			transcription, induced			20655004	22	3	13		
SCN2A	Channel, sodium; Membrane protein, integral; Membrane protein, multi-pass	P04775	24766	Scn2a		rat	Y1893	PHOSPHORYLATION	1046201	SNPSKVSyEPITTTL		molecular association, regulation; activity, inhibited		Fyn(INDUCES)		970058	1	0	1		
OGG1	DNA repair; Deoxyribonuclease; EC 3.2.2.-; EC 4.2.99.18; Lyase	O15527	4968	OGG1	3p26.2	human	S280	PHOSPHORYLATION	10036105	HIAQRDYsWHPTTSQ	HhH-GPD	enzymatic activity, inhibited				9985908	1	0	0		
Mnk1	EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, CAMK; Protein kinase, Ser/Thr (non-receptor); Translation	O08605	17346	Mknk1		mouse	T214	PHOSPHORYLATION	447622	ITTPELTtPCGSAEY	Pkinase	molecular association, regulation; enzymatic activity, induced		eIF4G(INDUCES)		2340	11	0	0		
LLGL1	Cell adhesion; Cytoskeletal protein; Motility/polarity/chemotaxis	NP_032528	16897	Llgl1		mouse	S658	PHOSPHORYLATION	449916	RVKSLKKsLRQSFRR		intracellular localization				2469	1	2	7		
SKP2	Ubiquitin conjugating system	Q13309	6502	SKP2	5p13	human	S64	PHOSPHORYLATION	457412	SNLGHPEsPPRKRLK		activity, induced; protein stabilization; ubiquitination; phosphorylation	cell cycle regulation			15022729	3	11	2		
GFAP	Cytoskeletal protein	P14136	2670	GFAP	17q21	human	S8	PHOSPHORYLATION	449618	MERRRITsAARRSYV	Filament_head	molecular association, regulation; protein stabilization		Fascin(INDUCES)		2254; 6337829	8	0	0		
IBTK	Protein kinase, regulatory subunit	Q9P2D0	25998	IBTK	6q14.1	human	S1203	PHOSPHORYLATION	15483703	LHSVSSKsFRDFLLE		molecular association, regulation		Btk(DISRUPTS)		21356308	1	0	0	regulation of the Btk:IBTK complex	
eplin	Actin binding protein; Cytoskeletal protein; Motility/polarity/chemotaxis	Q9UHB6	51474	LIMA1	12q13	human	S604	PHOSPHORYLATION	459750	FQSTSVKsPKTVSPP		protein degradation; ubiquitination	carcinogenesis, induced			27257057	2	13	15	E-cadherin down regulation, EMT	
PXN	Adaptor/scaffold; Cell adhesion; Cytoskeletal protein; Motility/polarity/chemotaxis	Q8VI36	19303	Pxn		mouse	Y118	PHOSPHORYLATION	448604	AGEEEHVySFPNKQK	Paxillin	activity, induced; molecular association, regulation; phosphorylation	apoptosis, altered; cell adhesion, induced; cell motility, altered; cytoskeletal reorganization; cell adhesion, altered	RASA1(INDUCES); vinculin(INDUCES)		5011228; 22879418; 3681; 8887	55	48	2522	regulates ERK phosphorylation; Paxillin Y31/118 phosphorylation promotes paxillin-vinculin interaction and vinculin recruitment to focal adhesions. ; Y31/118 phosphorylation induces RhoA activation. 	
N-Myc	DNA binding protein; Transcription factor	P04198	4613	MYCN	2p24.3	human	T58	PHOSPHORYLATION	448223	KKFELLPtPPLSPSR	Myc_N	molecular association, regulation; ubiquitination		AurA(INDUCES)		7550801	1	12	12		
NKCC1	Membrane protein, integral; Membrane protein, multi-pass; Transporter	P55011	6558	SLC12A2	5q23.3	human	T212	PHOSPHORYLATION	455545	TNTYYLRtFGHNTMD	AA_permease_N	activity, induced				8682; 8161; 5431	10	6	12		
GLUT2	Membrane protein, integral; Membrane protein, multi-pass; Transporter	P12336	25351	Slc2a2		rat	S489	PHOSPHORYLATION	451344	VPETKGKsFDEIAAE	Sugar_tr	activity, inhibited				3556	1	0	0	Phosphorylation reduces the initial rate of 3-O-methyl glucose uptake.	
SPRED2	Motility/polarity/chemotaxis; Vesicle protein	Q7Z698	200734	SPRED2	2p14	human	Y231	PHOSPHORYLATION	471404	WMTGYEDyRHAPVRG		protein degradation				9128	1	0	7	Pervanadate induced  Spred-2 degredation in ME4405 cells which is dependent on ubiquitination. 	
FcER1B	Membrane protein, integral; Membrane protein, multi-pass; Receptor, misc.	P13386	25316	Ms4a2		rat	Y228	PHOSPHORYLATION	2883702	LHVYSPIySALEDTR	SUR7	molecular association, regulation		Shc1(INDUCES); Syk(INDUCES); SHIP(INDUCES); SHP-1(INDUCES); Grb2(INDUCES)		2875302	0	1	0	SHIP binding is senstive to the presence of Syk.	
GAP43	Cell surface	P07936	29423	Gap43		rat	S41	PHOSPHORYLATION	448719	AATKIQAsFRGHITR	IQ		cytoskeletal reorganization; cell adhesion, altered; cell growth, altered			6829241	14	8	5	binds and stabilizes F-actin filaments	
HDAC7	EC 3.5.1.98; Hydrolase	Q8C2B3	56233	Hdac7		mouse	S178	PHOSPHORYLATION	455620	FPLRKTVsEPNLKLR		molecular association, regulation		14-3-3 epsilon(DISRUPTS)		4281702	7	11	32		
TEBP	Chaperone; EC 5.3.99.3; Isomerase; Transferase	Q15185	10728	PTGES3	12q13.3|12	human	S118	PHOSPHORYLATION	451130	DDSDEDMsNFDRFSE	Pkinase_C	molecular association, regulation; enzymatic activity, induced		HSP90A(INDUCES); CK2A1(INDUCES)		3331	1	9	3		
PIP5K1B	Carbohydrate Metabolism - inositol phosphate; EC 2.7.1.68; Kinase, lipid	O14986	8395	PIP5K1B	9q13	human	Y105	PHOSPHORYLATION	9471801	FGIKPDDyLYSICSE		intracellular localization; enzymatic activity, inhibited	cytoskeletal reorganization			9158115	1	0	0		
Kit	EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Protein kinase, TK; Protein kinase, tyrosine (receptor)	P10721	3815	KIT	4q11-q12	human	Y721	PHOSPHORYLATION	448017	CSDSTNEyMDMKPGV	Pkinase_Tyr	activity, induced	cell adhesion, altered			22518522; 5243	13	5	53		
PAR3-alpha	Adaptor/scaffold; Motility/polarity/chemotaxis	Q9Z340	81918	Pard3		rat	S1116	PHOSPHORYLATION	28758704	ALNARPQsPREGHLM		molecular association, regulation; intracellular localization	cytoskeletal reorganization	KIF3A(DISRUPTS)		28722171	1	0	0	S1116-p inhibits transport of Par3 toward the distal part of axon and regulates polarity.	
Kv11.1	Channel, potassium; Membrane protein, integral; Membrane protein, multi-pass; Motility/polarity/chemotaxis	Q12809	3757	KCNH2	7q36.1	human	T895	PHOSPHORYLATION	4974500	KLSFRRRtDKDTEQP		activity, inhibited				4641418; 10292905	4	0	1	rapid reduction in channel current; reduces basal channel current  amplitude	
TTC3	Cell development/differentiation; EC 6.3.2.-; EC 6.3.2.19; Ligase; UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase	P53804	7267	TTC3	21q22.2	human	S378	PHOSPHORYLATION	12473003	AYTPRSLsAPIFTTS		ubiquitination; enzymatic activity, induced	cell cycle regulation			12343100	1	0	0	facilitates proteasomal degradation of Akt1	
Chk2	EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, CAMK; Protein kinase, Ser/Thr (non-receptor)	O96017	11200	CHEK2	22q12.1	human	S372	PHOSPHORYLATION	17534900	KITDFGHsKILGETS	Pkinase	intracellular localization				15658725	1	1	0	chromatin targeting of S372, S379, T389, singly and T383/389, T378/S379	
ANTXR2	Membrane protein, integral; Receptor, misc.	P58335	118429	ANTXR2	4q21.21	human	Y381	PHOSPHORYLATION	3697372	PTVDASYyGGRGVGG	DUF3328	ubiquitination				13270511	1	1	36		
FAK	EC 2.7.1.112; EC 2.7.10.2; KINASE; Kinase, protein; Protein kinase, TK; Protein kinase, tyrosine (non-receptor)	P34152	14083	Ptk2		mouse	Y963	PHOSPHORYLATION	447966	DRSNDKVyENVTGLV	Focal_AT	molecular association, regulation; enzymatic activity, induced; phosphorylation	cell motility, altered; cytoskeletal reorganization; cell adhesion, altered; cell growth, altered	PXN(DISRUPTS); PXN(INDUCES)		14821603; 6702310	70	10	434	regulates VEGF expression and ERK phosphorylation; axon remodeling, disassembly from paxillin	
PIAS2	EC 6.3.2.-; Nuclear receptor co-regulator; SUMO LIGASE; SUMO conjugating system; Transcription, coactivator/corepressor	Q6AZ28	83422	Pias2		rat	S113	PHOSPHORYLATION	464653	STSIAPHsPSSPVAS			transcription, altered			7899	1	0	0	important for Elk1-mediated transcriptional activation 	
Gab2	Adaptor/scaffold	Q9Z1S8	14389	Gab2		mouse	Y632	PHOSPHORYLATION	450913	TSDEKVDyVQVDKEK		molecular association, regulation	cell differentiation, altered; cell growth, altered	SHP-2(INDUCES)		1342	4	5	172		
PKD1	Autophagy; EC 2.7.11.13; KINASE; Kinase, protein; Motility/polarity/chemotaxis; Protein kinase, CAMK; Protein kinase, Ser/Thr (non-receptor)	Q62101	18760	Prkd1		mouse	S748	PHOSPHORYLATION	448590	GEKSFRRsVVGTPAY	Pkinase	enzymatic activity, induced				3602; 830; 4684; 5506; 2440; 2449	47	27	23		
FRAT1	Oncoprotein; Transcription regulation	Q92837	10023	FRAT1	10q24.1	human	S188	PHOSPHORYLATION	471366	RLQQRRGsQPETRTG	GSK-3_bind	protein degradation; activity, inhibited	transcription, inhibited			9099	1	0	0	phosphorylation of this site inhibits FRAT1 activity (towards GSK3beta) and reduces its ability to activate beta catenin-TCF/LEF-dependent transcription	
Kv2.1	Channel, cation; Channel, ligand-gated; Channel, potassium; Membrane protein, integral; Membrane protein, multi-pass	P15387	25736	Kcnb1		rat	S804	PHOSPHORYLATION	473562	ESSPLPTsPKFLRPN		activity, induced; intracellular localization	apoptosis, induced			9359	6	7	0	regulates potassium current during oxidant-induced apoptosis	
BAF	DNA binding protein	O75531	8815	BANF1	11q13.1	human	T3	PHOSPHORYLATION	7105313	_____MTtSQKHRDF	BAF	molecular association, regulation; intracellular localization			DNA(DISRUPTS)	12619500	1	0	0		
PPP1CA	EC 3.1.3.16; PHOSPHATASE; Protein phosphatase, Ser/Thr (non-receptor)	P62137	19045	Ppp1ca		mouse	T320	PHOSPHORYLATION	448686	NPGGRPItPPRNSAK		intracellular localization				762	19	23	82		
CD10	EC 3.4.24.11; Membrane protein, integral; Protease	P08473	4311	MME	3q25.2	human	S6	PHOSPHORYLATION	3850156	__MGKSEsQMDITDI		molecular association, regulation; phosphorylation		PTEN(DISRUPTS)		15755118	2	8	12	phosphorylation of this site (MME S6D mutant) increases insulin/IGF-1 stimulated activation of Akt 	
TOP2A	EC 5.99.1.3; Isomerase	P11388	7153	TOP2A	17q21-q22	human	S1361	PHOSPHORYLATION	455094	SPPKTKTsPKLSNKE		protein degradation; molecular association, regulation; ubiquitination		FBXW7(INDUCES)		18119105	2	0	0		
SNCA	Adaptor/scaffold	P37840	6622	SNCA	4q21	human	Y39	PHOSPHORYLATION	3546424	KTKEGVLyVGSKTKE	Synuclein	molecular association, regulation; phosphorylation	apoptosis, altered	SNCA(DISRUPTS)		3548311	1	1	11	decreases phosphorylation of S129 SNCA	
CEACAM1	Cell adhesion; Immunoglobulin superfamily; Membrane protein, integral; Motility/polarity/chemotaxis	P16573	81613	Ceacam1		rat	S503	PHOSPHORYLATION	448536	QQSKRPTsASSSPTE		activity, induced; receptor internalization, altered; intracellular localization				2572; 3180; 2573; 5358	8	0	0	increases insulin receptor internalization and insulin clearance from blood	
CSF2RB	Membrane protein, integral; Receptor, cytokine	P26955	12983	Csf2rb		mouse	Y595	PHOSPHORYLATION	450103	SFDFNGPyLGPPQSH		molecular association, regulation	cell growth, altered	Shc1(INDUCES); PIK3R1(INDUCES)		7441	12	0	0	Phosphorylation of Y595 and S603 are exclusive. Y595 phosphorylation induces binding to Shc and prevents binding to 14-3-3.	
PPP1R2	Inhibitor protein; Motility/polarity/chemotaxis; Protein phosphatase, regulatory subunit	P41236	5504	PPP1R2	3q29	human	S87	PHOSPHORYLATION	449054	GDDEDACsDTEATEA	IPP-2	intracellular localization				3958	3	13	5	Phosphorylation is required for nuclear localization during S phase.	
ERK5	EC 2.7.11.24; KINASE; Kinase, protein; Protein kinase, CMGC; Protein kinase, Ser/Thr (non-receptor)	Q9WVS8	23939	Mapk7		mouse	S764	PHOSPHORYLATION	14561006	QADSASLsASLLADW			transcription, altered			14551427	1	1	0		
Notch 1	Membrane protein, integral; Motility/polarity/chemotaxis; Receptor, misc.; Transcription factor	Q01705	18128	Notch1		mouse	K2161	ACETYLATION	18899507	KGLACGSkEAKDLKA		protein stabilization; ubiquitination				18899000	1	1	0		
FAF1	Apoptosis; Nuclear receptor co-regulator	Q9UNN5	11124	FAF1	1p33	human	S291	PHOSPHORYLATION	450287	DVHMVSDsDGDDFED		intracellular localization	cell cycle regulation			5354442; 2917	2	1	0	 mediates the proteasome-dependent degradation of AurA; induces G2/M arrest	
IRS1	Adaptor/scaffold; Motility/polarity/chemotaxis	P35568	3667	IRS1	2q36	human	S24	PHOSPHORYLATION	455604	GYLRKPKsMHKRFFV	PH	molecular association, regulation		PIK3C2A(INDUCES); InsR(INDUCES)		5507	2	1	0		
caldesmon	Actin binding protein	P12957	373965	CALD1		chicken	S702	PHOSPHORYLATION	456707	GLKVGVSsRINEWLT	Caldesmon	molecular association, regulation		calmodulin(DISRUPTS)		15571612	5	1	0		
NMDAR2A	Channel, ligand-gated; Membrane protein, integral; Membrane protein, multi-pass	Q00959	24409	Grin2a		rat	S1416	PHOSPHORYLATION	455790	ASYCSRDsRGHSDVY	NMDAR2_C	molecular association, regulation		CAMK2A(DISRUPTS)		5942	1	0	0		
DOR-1	GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR	P41143	4985	OPRD1	1p36.1-p34.3	human	S363	PHOSPHORYLATION	448550	RVTACTPsDGPGGGA		receptor desensitization, altered; receptor internalization, altered				2701904; 4862623	10	1	0	S363A mutant blocked receptor desensitization and internalization in the presence of sucrose.	
UGT2B7	Carbohydrate Metabolism - ascorbate and aldarate; Carbohydrate Metabolism - pentose and glucuronate interconversions; Carbohydrate Metabolism - starch and sucrose; Cofactor and Vitamin Metabolism - porphyrin and chlorophyll; Cofactor and Vitamin Metabolism - retinol; EC 2.4.1.17; Lipid Metabolism - androgen and estrogen; Membrane protein, integral; Transferase; Xenobiotic Metabolism - drug metabolism - cytochrome P450; Xenobiotic Metabolism - drug metabolism - other enzymes; Xenobiotic Metabolism - metabolism by cytochrome P450	P16662	7364	UGT2B7	4q13	human	Y236	PHOSPHORYLATION	7378200	MKKWDQFySEVLGRP	UDPGT	enzymatic activity, induced				7324313	2	0	0		
calnexin	Calcium-binding protein; Endoplasmic reticulum; Membrane protein, integral; Motility/polarity/chemotaxis	P24643		CANX		dog	S555	PHOSPHORYLATION	456359	KLEEKQKsDAEEDGG	Ycf1; Bravo_FIGEY; DUF1510; TRAP_alpha	molecular association, regulation; intracellular localization		PACS2(DISRUPTS)		2704325	2	44	66		
GYS2	Carbohydrate Metabolism - starch and sucrose; Cytoskeletal protein; EC 2.4.1.11; Transferase	P17625	25623	Gys2		rat	S8	PHOSPHORYLATION	484503	MLRGRSLsVTSLGGL		intracellular localization; enzymatic activity, inhibited				7124716	1	6	0	translocation dependent on glycogen synthesis	
AIP	Transcription, coactivator/corepressor	O00170	9049	AIP	11q13.3	human	S131	PHOSPHORYLATION	10888701	VAQMREHsSLGHADL		molecular association, regulation		HSP90A(INDUCES)		10167104	1	0	0		
EGFR	EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Protein kinase, TK; Protein kinase, tyrosine (receptor)	Q01279	13649	Egfr		mouse	Y1197	PHOSPHORYLATION	448060	PTAENAEyLRVAPPS			apoptosis, inhibited			6784	70	32	984		
tau iso8	Cytoskeletal protein	P10636-8	4137	MAPT	17q21.1	human	S202	PHOSPHORYLATION	447928	SGYSSPGsPGTPGSR		O-GlcNAc glycosylation; molecular association, regulation; intracellular localization; protein conformation	cytoskeletal reorganization	Fyn(DISRUPTS); tau(INDUCES)		4420; 5955610; 5955607; 8165400; 7021; 3579; 9223; 6115906; 17630402	85	30	104	The amount of tau in partticulate fraction increased in R406W and V337M mutants compared to WT.; Pseudophosphorylation mutants S199E, T212E, S214E, double mutant T212E/S214E, and triple mutant S199E/202E/T205E showed increased filament mass at equilibrium in vitro, as compared to WT tau. S212E mutant showed longer filament lengths compared to WT in vitro.	
HER4	EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Protein kinase, TK; Protein kinase, tyrosine (receptor)	Q15303	2066	ERBB4	2q33.3-q34	human	Y1128	PHOSPHORYLATION	461025	EDSSTQRySADPTVF		molecular association, regulation		Src(INDUCES); STAT1(INDUCES)		4651319	0	1	1		
HSF1	DNA binding protein; Transcription factor	Q00613	3297	HSF1	8q24.3	human	K298	SUMOYLATION	3656302	SSPLVRVkEEPPSPP	Vert_HS_TF		transcription, inhibited			8471500	4	0	0		
SLAP-130	Adaptor/scaffold	O15117	2533	FYB	5p13.1	human	Y771	PHOSPHORYLATION	449430	ADNDGEIyDDIADGC			cell motility, altered; cell adhesion, altered			15020906	3	2	88	promotes adhesion to ICAM-1; promotes cell migration	
Ret	EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Protein kinase, TK; Protein kinase, tyrosine (receptor)	P07949	5979	RET	10q11.2	human	Y1015	PHOSPHORYLATION	449894	MMVKRRDyLDLAAST			transcription, altered; cell growth, altered			8774; 8773	11	0	0		
Abl	EC 2.7.1.112; EC 2.7.10.2; KINASE; Kinase, protein; Protein kinase, TK; Protein kinase, tyrosine (non-receptor)	P00520	11350	Abl1		mouse	Y226	PHOSPHORYLATION	450303	KRNKPTIyGVSPNYD		enzymatic activity, induced				5735; 998; 12482266	15	10	306		
Notch 1	Membrane protein, integral; Motility/polarity/chemotaxis; Receptor, misc.; Transcription factor	Q01705	18128	Notch1		mouse	K1772	ACETYLATION	18899503	VSEASKKkRREPLGE		protein stabilization; ubiquitination				18899000	1	1	0		
Smad3	DNA binding protein; Nuclear receptor co-regulator; Transcription factor	P84022	4088	SMAD3	15q22.33	human	S423	PHOSPHORYLATION	448335	SPSIRCSsVS_____		activity, induced; protein conformation	cell motility, altered; transcription, altered			6277008; 1275	16	0	5	induce vascular invasion; The triple mutants(S422/423/425A and S422/423/425D) were used in these experiments 	
SH3BP2	Adaptor/scaffold	P78314	6452	SH3BP2	4p16.3	human	S225	PHOSPHORYLATION	455469	SDMPRAHsFTSKGPG		molecular association, regulation		14-3-3 theta(INDUCES)		5370	1	2	0		
HER2	EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Protein kinase, TK; Protein kinase, tyrosine (receptor)	P04626	2064	ERBB2	17q12	human	T686	PHOSPHORYLATION	451817	QQKIRKYtMRRLLQE	DUF4381	receptor internalization, altered; intracellular localization; phosphorylation		AP2A1(NOT_REPORTED); SHP-2(NOT_REPORTED)		3952; 4641425	5	0	0	increases HER2/3 and MEK/ERK phosphorylation	
CPT1A	EC 2.3.1.21; Lipid Metabolism - fatty acid; Membrane protein, integral; Membrane protein, multi-pass; Mitochondrial; Transferase	P32198	25757	Cpt1a		rat	S747	PHOSPHORYLATION	479871	FSSPETDsHRFGKHL	Carn_acyltransf	enzymatic activity, induced				8396	1	1	0	in vitro	
JNK2	EC 2.7.11.24; KINASE; Kinase, protein; Protein kinase, CMGC; Protein kinase, Ser/Thr (non-receptor)	Q9WTU6	26420	Mapk9		mouse	Y185	PHOSPHORYLATION	447652	TNFMMTPyVVTRYYR	Pkinase	enzymatic activity, induced				6735	59	22	1424		
RhoGDI alpha	Apoptosis; Cell adhesion; Cell development/differentiation; G protein regulator, misc.; Motility/polarity/chemotaxis	Q5XI73	360678	Arhgdia		rat	S34	PHOSPHORYLATION	467490	YKPPAQKsIQEIQEL	Rho_GDI	molecular association, regulation	cell growth, altered	RAC1(DISRUPTS); Cdc42 iso1(DISRUPTS)		6829223	4	11	0	in response to bFGF stimulation	
cortactin	Actin binding protein; Cytoskeletal protein; Motility/polarity/chemotaxis	Q60598	13043	Cttn		mouse	S405	PHOSPHORYLATION	447700	KKQTPPAsPSPQPIE			cell cycle regulation; cell motility, altered			2790302	14	46	113		
Kv4.2	Channel, potassium; Membrane protein, integral; Membrane protein, multi-pass	Q9NZV8	3751	KCND2	7q31	human	S552	PHOSPHORYLATION	450462	VSGSHQGsIQELSTI		protein stabilization; intracellular localization				12558720	5	7	0	KCNIP4-mediated enhancement of channel surface expression	
Shc1 iso2	Adaptor/scaffold; Apoptosis; Mitochondrial; Motility/polarity/chemotaxis	P29353-2	6464	SHC1	1q21	human	Y317	PHOSPHORYLATION	448511	ELFDDPSyVNVQNLD		activity, induced; molecular association, regulation; phosphorylation	cell differentiation, altered; cell motility, altered; apoptosis, inhibited; cytoskeletal reorganization; cell growth, altered	SOS1(INDUCES); SHIP(INDUCES); ZAP70(INDUCES); VAV1(INDUCES); PIK3R1(INDUCES); Grb2(INDUCES)		762700; 673; 8804; 783; 8868; 8168	36	61	1965	f-actin cytoskeleton, chemotaxis.	
dynactin 1	Microtubule binding protein; Motility/polarity/chemotaxis; Motor protein	P28023	29167	Dctn1		rat	S19	PHOSPHORYLATION	455515	TPSGSRMsTEASARP			cytoskeletal reorganization			5364	2	0	0		
PSEN1	Cell surface; EC 3.4.23.-; Membrane protein, integral; Membrane protein, multi-pass; Mitochondrial; Protease	P49768	5663	PSEN1	14q24.3	human	T320	PHOSPHORYLATION	3397302	SKYNAEStERESQDT	Presenilin	protein stabilization; enzymatic activity, induced				3301200	1	0	0		
GABRB1	Channel, chloride; Channel, ligand-gated; Membrane protein, integral; Membrane protein, multi-pass	P50571	14400	Gabrb1		mouse	S410	PHOSPHORYLATION	10296601	QYRKPLSsREGFGRG	Neur_chan_memb	activity, induced				10144229	1	0	0		
PDHA1	Amino Acid Metabolism - valine, leucine and isoleucine biosynthesis; Carbohydrate Metabolism - butanoate; Carbohydrate Metabolism - citrate (TCA) cycle; Carbohydrate Metabolism - glycolysis and gluconeogenesis; Carbohydrate Metabolism - pyruvate; EC 1.2.4.1; Mitochondrial; Oxidoreductase	P08559	5160	PDHA1	Xp22.1	human	S293	PHOSPHORYLATION	448258	TYRYHGHsMSDPGVS	E1_dh	enzymatic activity, inhibited				1673; 11443; 2509	25	59	655	 based on effect of Ser>Glu mutation; in vitro	
DVL2	Adaptor/scaffold; Motility/polarity/chemotaxis	O14641	1856	DVL2	17p13.1	human	S143	PHOSPHORYLATION	7320089	FHPNVSSsHENLEPE		molecular association, regulation; intracellular localization	cytoskeletal reorganization	PLK1(INDUCES)		25347040	1	2	0	important for cilia resorption	
UBF	DNA binding protein; Transcription factor	P25977	25574	Ubtf		rat	S389	PHOSPHORYLATION	450170	INKKQTTsPASKKPS		molecular association, regulation	transcription, induced; transcription, altered	POLR1A(INDUCES); TIF1B(INDUCES); p14ARF(DISRUPTS)		9196; 17482920	3	2	1		
PIP4K2B	Carbohydrate Metabolism - inositol phosphate; EC 2.7.1.149; EC 2.7.1.68; Kinase, lipid; Motility/polarity/chemotaxis	P78356	8396	PIP4K2B	17q12	human	S326	PHOSPHORYLATION	470107	SYGTPPDsPGNLLSF	PIP5K	enzymatic activity, inhibited				8965	1	8	13		
AKAP12	Adaptor/scaffold	Q5QD51	83425	Akap12		rat	S515	PHOSPHORYLATION	469988	SSGLKKLsGKKQKGK		molecular association, regulation	cell cycle regulation	CCNE1(DISRUPTS); CCND1(DISRUPTS)		8827; 8828	1	1	0	shown with PKC phosphorylated and nonphosphorylated AKAP12; in vivo permeable peptide/phosphopeptide experiments	
Bcr	EC 2.7.11.1; GTPase activating protein, Rac/Rho; KINASE; Kinase, protein; Protein kinase, ATYPICAL; Protein kinase, Ser/Thr (non-receptor)	P11274	613	BCR	22q11.23	human	Y177	PHOSPHORYLATION	447792	ADAEKPFyVNVEFHH		molecular association, regulation; phosphorylation	carcinogenesis, induced; cell motility, altered; apoptosis, inhibited; cell growth, altered	SOS1(INDUCES); Hck(DISRUPTS); Gab2(INDUCES); Grb2(INDUCES)		2852643; 3943; 3961; 2610; 1745; 1754	12	20	957	Grb2 binding site regulates tyrosine phosphorylation of Gab2. 	
ELK3	DNA binding protein; Transcription factor	P41971	13713	Elk3		mouse	S359	PHOSPHORYLATION	450031	IHFWSSLsPVAPLSP		activity, induced; intracellular localization	transcription, altered; cell growth, altered			4317100; 1187	2	0	0	pro-B cell expansion	
MDC1	Cell cycle regulation	Q14676	9656	MDC1	6p21.3	human	S218	PHOSPHORYLATION	4213800	PFAFNLNsDTDVEEG		molecular association, regulation	cell cycle regulation	NBS1(INDUCES)		4042508	1	1	6	MDC1-NBS1 interaction regulates intra-S-phase checkpoint activation	
PSRC1	Tumor suppressor	Q6PGN9	84722	PSRC1	1p13.3	human	S225	PHOSPHORYLATION	18963102	AKLRVSGsGEFVGLT			cytoskeletal reorganization			18898704	1	1	0		
p63	DNA binding protein; Transcription factor	Q9H3D4	8626	TP63	3q28	human	S51	PHOSPHORYLATION	28802100	TQTNEFLsPEVFQHI		molecular association, regulation	transcription, inhibited	p300(DISRUPTS)		27902339	1	1	0		
SH3GLB1	Apoptosis; Autophagy; EC 2.3.1.-; Mitochondrial; Transferase	Q9Y371	51100	SH3GLB1	1p22	human	Y80	PHOSPHORYLATION	465105	ARIEEFVyEKLDRKA	BAR	molecular association, regulation	apoptosis, inhibited	Bax(DISRUPTS)		2807214	1	6	271		
tau iso8	Cytoskeletal protein	P10636-8	4137	MAPT	17q21.1	human	S258	PHOSPHORYLATION	487453	PDLKNVKsKIGSTEN	Tubulin-binding	molecular association, regulation				19084437	2	1	0	in vitro microtubule binding	
HHEX	DNA binding protein; Transcription factor	Q03014	3087	HHEX	10q23.33	human	S163	PHOSPHORYLATION	7430500	FETQKYLsPPERKRL	Homeobox; ArsC	molecular association, regulation	transcription, induced		DNA(INDUCES)	7313802	1	0	1		
CD33	Cell adhesion; Membrane protein, integral	P20138	945	CD33	19q13.3	human	Y340	PHOSPHORYLATION	450952	EMDEELHyASLNFHG		molecular association, regulation		SHP-2(INDUCES); SHP-1(INDUCES)		7073; 3223	2	0	0		
IkB-alpha	DNA binding protein; Inhibitor protein	Q9Z1E3	18035	Nfkbia		mouse	S36	PHOSPHORYLATION	448204	RHDSGLDsMKDEEYE		protein degradation				5520	80	1	5		
NPHP1	Cell adhesion	O15259	4867	NPHP1	2q13	human	Y349	PHOSPHORYLATION	18449510	GNQFRANyFLQPELM		molecular association, regulation; intracellular localization		PACS-1(INDUCES)		18410856	1	0	0		
axin 1	Adaptor/scaffold	O70239	79257	Axin1		rat	S321	PHOSPHORYLATION	2226507	PATSANDsEQQSLSS			cytoskeletal reorganization			25797201	1	0	0	Phosphorylation regulates responsive to Sema3A induced growth cone collapse.	
SLAP-130	Adaptor/scaffold	O15117	2533	FYB	5p13.1	human	Y559	PHOSPHORYLATION	15149800	GRTARGSyGYIKTTA	Ycf1; SH3_2		cell motility, altered; cell adhesion, altered			15020906	1	1	7	promotes adhesion to fibronectin; promotes cell migration	
TNNI3	Actin binding protein; Motility/polarity/chemotaxis; Motor protein	P19429	7137	TNNI3	19q13.4	human	S39	PHOSPHORYLATION	3146608	EPHAKKKsKISASRK		molecular association, regulation		TNNC1(DISRUPTS)		8869	1	0	0		
ADD2	Cytoskeletal protein; Motility/polarity/chemotaxis	Q05764	24171	Add2		rat	S606	PHOSPHORYLATION	3147414	TPASPVQsPTRAGTK	DUF3614		cytoskeletal reorganization			23940900	1	11	0		
NHE1	Membrane protein, integral; Membrane protein, multi-pass; Motility/polarity/chemotaxis; Transporter	P19634	6548	SLC9A1	1p36.1-p35	human	S771	PHOSPHORYLATION	475074	MRSKETSsPGTDDVF		activity, induced; protein stabilization; protein conformation				9266; 27935600	4	2	0	phosphomimetic mutant was strongly stabilized and resulted in a more compact region which affects NHE1 activity.	
Kv2.1	Channel, cation; Channel, ligand-gated; Channel, potassium; Membrane protein, integral; Membrane protein, multi-pass	Q14721	3745	KCNB1	20q13.2	human	S800	PHOSPHORYLATION	473567	EKNHFESsPLPTSPK		activity, induced				9721217; 28722403	4	3	0	increased channel activity	
NHERF	Adaptor/scaffold; Motility/polarity/chemotaxis	O14745	9368	SLC9A3R1	17q25.1	human	S162	PHOSPHORYLATION	450312	CTMKKGPsGYGFNLH	PDZ	molecular association, regulation		CFTR(DISRUPTS)		2923	2	3	1		
Abl	EC 2.7.1.112; EC 2.7.10.2; KINASE; Kinase, protein; Protein kinase, TK; Protein kinase, tyrosine (non-receptor)	P00519	25	ABL1	9q34.1	human	S446	PHOSPHORYLATION	450296	PYPGIDLsQVYELLE	Pkinase_Tyr	enzymatic activity, induced				1000	2	0	0		
STXBP3	Vesicle protein	Q60770	20912	Stxbp3		mouse	Y218	PHOSPHORYLATION	463817	VEKKLEDyYKIDEKG	Sec1	molecular association, regulation		STX4(DISRUPTS)		28722429	2	0	0	2-deoxy-glucose uptake in adipocytes	
NR4A2	DNA binding protein; Nuclear receptor	P43354	4929	NR4A2	2q22-q23	human	T132	PHOSPHORYLATION	487426	SSPPTPTtPGFQVQH			transcription, induced			12244	1	0	0		
Lck	EC 2.7.10.2; KINASE; Kinase, protein; Protein kinase, TK; Protein kinase, tyrosine (non-receptor)	P06239	3932	LCK	1p34.3	human	Y505	PHOSPHORYLATION	447823	FTATEGQyQPQP___		molecular association, regulation; intracellular localization; enzymatic activity, inhibited; protein conformation; activity, inhibited; phosphorylation	cell growth, altered	Lck(INDUCES)		4914022; 2244; 1652; 704; 27519611; 15031330; 705; 3361008	35	22	796		
PGAM1	Carbohydrate Metabolism - glycolysis and gluconeogenesis; EC 3.1.3.13; EC 5.4.2.1; EC 5.4.2.4; Isomerase; Phosphatase (non-protein)	P18669	5223	PGAM1	10q25.3	human	S23	PHOSPHORYLATION	455496	WNLENRFsGWYDADL	His_Phos_1	enzymatic activity, inhibited				5340	1	7	15		
eEF1A2	Translation; Translation elongation	Q05639	1917	EEF1A2	20q13.3	human	S205	PHOSPHORYLATION	27930804	GDNMLEPsPNMPWFK	GTP_EFTU	protein degradation; molecular association, regulation				27902349	1	0	0	increased association with polysomes and  newly synthesized polypeptides (NSPs)	
eNOS	Amino Acid Metabolism - arginine and proline; EC 1.14.13.39; Oxidoreductase	P29474	4846	NOS3	7q36	human	S1177	PHOSPHORYLATION	447884	TSRIRTQsFSLQERQ		intracellular localization; enzymatic activity, induced	cell differentiation, altered; cell motility, altered; cytoskeletal reorganization			4459; 6421501; 6011113; 5829; 4861514; 5121514; 6786; 6575; 6235; 2547; 5393; 5493; 6236; 4527; 7309806	141	8	7		
BCKDH E1-alpha	Amino Acid Metabolism - valine, leucine and isoleucine degradation; EC 1.2.4.4; Lyase; Mitochondrial; Oxidoreductase	P11960	25244	Bckdha		rat	S343	PHOSPHORYLATION	451657	DDSSAYRsVDEVNYW	E1_dh	enzymatic activity, inhibited				4706	3	41	32		
ELF3	DNA binding protein; Motility/polarity/chemotaxis; Transcription factor	P78545	1999	ELF3	1q32.2	human	S207	PHOSPHORYLATION	482811	GTGASRSsHSSDSGG		protein stabilization; ubiquitination; phosphorylation	transcription, induced; cell growth, altered			11768	1	0	0		
SOS1	Adaptor/scaffold; Guanine nucleotide exchange factor, Ras; Motility/polarity/chemotaxis	Q07889	6654	SOS1	2p21	human	S1197	PHOSPHORYLATION	451317	KAYSPRYsISDRTSI		molecular association, regulation		Grb2(DISRUPTS)		3524	1	0	0		
DAZAP1	Motility/polarity/chemotaxis; RNA binding protein	Q96EP5	26528	DAZAP1	19p13.3	human	T315	PHOSPHORYLATION	467205	GVPPPPAtPGAAPLA		molecular association, regulation		DAZ1(DISRUPTS)		8163	1	0	0		
EZH2	EC 2.1.1.43; METHYLTRANSFERASE; Methyltransferase; Methyltransferase, protein lysine; Oncoprotein	Q15910	2146	EZH2	7q35-q36	human	T487	PHOSPHORYLATION	452848	APAEDVDtPPRKKKR		protein degradation; ubiquitination	cell growth, induced			20726610	3	27	56		
KCNMA1	Channel, potassium; Endoplasmic reticulum; Membrane protein, integral; Membrane protein, multi-pass	Q08460	16531	Kcnma1		mouse	S938	PHOSPHORYLATION	469989	HGMLRQPsITTGVNI		activity, induced				8836	4	1	0	Channel activation is dependent on S938 phosphorylation.	
CREB	DNA binding protein; Transcription factor	P16220	1385	CREB1	2q34	human	S133	PHOSPHORYLATION	448228	EILSRRPsYRKILND	pKID	activity, induced; molecular association, regulation; phosphorylation	cell differentiation, altered; cell growth, induced; cell motility, altered; apoptosis, inhibited; transcription, induced; transcription, altered	Myb(INDUCES); Nur77(INDUCES); MEIS1(INDUCES); p300(INDUCES); RGS13(INDUCES); CBP(INDUCES); TORC2(NOT_REPORTED); SOX9(INDUCES)	DNA(INDUCES)	7324114; 1173033; 9201006; 13270510; 5653; 4501; 3404209; 2461600; 2300; 7037; 1461; 14780517; 3643; 4316; 4466; 7309808; 11554706; 1969111; 7324123; 7991107; 11463; 2646; 15031316; 6011110; 1173038	214	1	61		
MAPKAPK5	EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, CAMK; Protein kinase, Ser/Thr (non-receptor)	O54992	17165	Mapkapk5		mouse	T182	PHOSPHORYLATION	450093	VDQGDLMtPQFTPYY	Pkinase	intracellular localization; enzymatic activity, induced				5453	6	3	69		
IRF3	DNA binding protein; Transcription factor	Q14653	3661	IRF3	19q13.3-q13.4	human	T390	PHOSPHORYLATION	14665000	GASSLENtVDLHISN		molecular association, regulation; phosphorylation		CBP(INDUCES)		14551405	1	1	0	stimulates phosphorylation of S396	
SIPA1L1	GTPase activating protein, Ras	O35412	246212	Sipa1l1		rat	S1344	PHOSPHORYLATION	26348503	LQGTSADsGIDTASY		protein degradation; molecular association, regulation; ubiquitination		BTRC(INDUCES)		25785421	1	0	0		
Src iso2	EC 2.7.10.2; KINASE; Kinase, protein; Protein kinase, TK; Protein kinase, tyrosine (non-receptor)	NP_001020566	20779	Src		mouse	Y529	PHOSPHORYLATION	448235	FTSTEPQyQPGENL_		enzymatic activity, inhibited	cell differentiation, altered			7324117	104	13	966		
GLUT2	Membrane protein, integral; Membrane protein, multi-pass; Transporter	P12336	25351	Slc2a2		rat	T510	PHOSPHORYLATION	451347	SAPPRKAtVQMEFLG		activity, inhibited				3556	1	0	0	Phosphorylation reduces the initial rate of 3-O-methyl glucose uptake.	
RCHY1	EC 6.3.2.-; EC 6.3.2.19; Nuclear receptor co-regulator; UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase	Q96PM5	25898	RCHY1	4q21.1	human	S211	PHOSPHORYLATION	27971904	VAQTPMPsEYQNMTV		ubiquitination; activity, inhibited	transcription, inhibited			27902309	1	0	0	self-ubiquitination, may contribute to p53-inhibition of transcriptional elongation of HIV-LTR 	
ATM	EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, ATYPICAL; Protein kinase, Ser/Thr (non-receptor)	Q62388	11920	Atm		mouse	S367	PHOSPHORYLATION	467198	DTRSVEIsQSYVTQR			chromatin organization, altered			5930010	3	5	1		
CIITA	DNA binding protein; Transcription, coactivator/corepressor	P33076	4261	CIITA	16p13	human	S373	PHOSPHORYLATION	1295502	VQARLERsSSKSLER		molecular association, regulation; activity, inhibited	transcription, inhibited	SIN3B(INDUCES)		1172829	1	0	0		
mAChR M2	GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR	P08172	1129	CHRM2	7q31-q35	human	Y177	PHOSPHORYLATION	487429	TVEDGECyIQFFSNA	7tm_1	molecular association, regulation; protein conformation				12276; 4042522	2	0	0		
NYAP2	Cell development/differentiation	Q8BM65	241134	Nyap2		mouse	Y300	PHOSPHORYLATION	455105	DDQSEAVyEEMKYPI		molecular association, regulation		PIK3R1(INDUCES)		25020801	1	3	33	localization to the neuronal plasma membrane, interaction with WAVE complex	
MDM2	EC 6.3.2.-; EC 6.3.2.19; Inhibitor protein; Ligase; UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase	Q00987	4193	MDM2	12q14.3-q15	human	S262	PHOSPHORYLATION	454944	DSEDYSLsEEGQELS		activity, induced				4379	3	1	0	promotes p53 degradation	
CCKBR	GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR	P32239	887	CCKBR	11p15.4	human	T440	PHOSPHORYLATION	17825902	LSRLSYTtISTLGPG		molecular association, regulation		ARRB1(INDUCES)		17675032	1	0	0		
cortactin	Actin binding protein; Cytoskeletal protein; Motility/polarity/chemotaxis	Q60598	13043	Cttn		mouse	T401	PHOSPHORYLATION	449245	QARAKKQtPPASPSP	FadA		cell cycle regulation; cell motility, altered			2790302	1	55	101		
GRF-1	GTPase activating protein, Rac/Rho; Motility/polarity/chemotaxis; Transcription factor	Q9NRY4	2909	ARHGAP35	19q13.3	human	S1150	PHOSPHORYLATION	457041	LERGRKVsIVSKPVL		molecular association, regulation; activity, inhibited		Rnd1(DISRUPTS)		6804206	1	17	55		
Bik	Apoptosis; Membrane protein, integral; Mitochondrial	Q13323	638	BIK	22q13.31	human	S35	PHOSPHORYLATION	448349	EVLGMTDsEEDLDPM	bcl-2I13	molecular association, regulation	apoptosis, induced	Bcl-2(INDUCES); Bcl-xL(INDUCES)		5312; 1755	2	0	0		
SOS1	Adaptor/scaffold; Guanine nucleotide exchange factor, Ras; Motility/polarity/chemotaxis	Q07889	6654	SOS1	2p21	human	S1193	PHOSPHORYLATION	451316	QPTSKAYsPRYSISD		molecular association, regulation		Grb2(DISRUPTS)		3524	1	0	0		
Cbl-c	EC 6.3.2.-; Ligase; UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase	Q9ULV8	23624	CBLC	19q13.2	human	Y341	PHOSPHORYLATION	14913506	SEEQLQLyWAMDSTF		molecular association, regulation; enzymatic activity, induced		UBE2D2(DISRUPTS)		14780522	1	0	0	in vitro	
MYH9	Actin binding protein; Motility/polarity/chemotaxis; Motor protein	P35579	4627	MYH9	22q13.1	human	S1803	PHOSPHORYLATION	2482303	EMEGTVKsKYKASIT	Myosin_tail_1; AAA_13	intracellular localization	cytoskeletal reorganization			2451809	1	1	1		
C/EBP-beta	DNA binding protein; Motility/polarity/chemotaxis; Transcription factor	P17676	1051	CEBPB	20q13.1	human	Y78	PHOSPHORYLATION	9397201	RAIDFSPyLEPLGAP		protein stabilization	cell cycle regulation; apoptosis, altered; transcription, induced			9201017	1	0	0		
PR	DNA binding protein; Nuclear receptor	P06401	5241	PGR	11q22-q23	human	K388	SUMOYLATION	486289	QPPALKIkEEEEGAE	Prog_receptor		transcription, inhibited; cell growth, altered			9980413	7	0	0	represses basal proliferation of breast cancer cells	
CREB	DNA binding protein; Transcription factor	P16220	1385	CREB1	2q34	human	S111	PHOSPHORYLATION	451808	TIAESEDsQESVDSV		molecular association, regulation; activity, inhibited; phosphorylation	transcription, inhibited	CBP(INDUCES)		9565; 7037	8	1	3		
BRCA1	EC 6.3.2.-; Nuclear receptor co-regulator; Transcription, coactivator/corepressor; Tumor suppressor; UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase	P38398	672	BRCA1	17q21	human	S1457	PHOSPHORYLATION	450008	SEKAVLTsQKSSEYP		molecular association, regulation		ATM(INDUCES)		1757	4	3	1		
PLEKHG6	Guanine nucleotide exchange factor, Rac/Rho	Q3KR16	55200	PLEKHG6	12p13.31	human	T574	PHOSPHORYLATION	4145508	HLVVTEDtDEDAPLV		activity, induced; intracellular localization				4042512	1	0	0	enhances PLEKHG6 activity towards RhoA	
GRK7	EC 2.7.1.-; EC 2.7.11.14; EC 2.7.11.16; KINASE; Kinase, protein; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor)	Q8WTQ7	131890	GRK7	3q24	human	S23	PHOSPHORYLATION	456354	YLQARKPsDCDSKEL		enzymatic activity, inhibited				6682	1	0	0	reaction in vitro	
CTNND2	Actin binding protein; Motility/polarity/chemotaxis	O35927	18163	Ctnnd2		mouse	T1078	PHOSPHORYLATION	2020381	RPYSSSRtPSISPVR		protein degradation; ubiquitination				9980409	1	4	0		
PLM	Cell surface; Channel, misc.; Membrane protein, integral	O00168	5348	FXYD1	19q13.1	human	S88	PHOSPHORYLATION	451425	RSSIRRLsTRRR___	IncA	molecular association, regulation		ATP1A1(DISRUPTS); PLM(INDUCES)		18021013	21	1	74	enhances PLM oligomerization and modulates its interaction with Na/K-ATPase (NKA)	
ACC1	Carbohydrate Metabolism - propanoate; Carbohydrate Metabolism - pyruvate; EC 6.3.4.14; EC 6.4.1.2; Ligase; Lipid Metabolism - fatty acid biosynthesis	P11497	60581	Acaca		rat	S29	PHOSPHORYLATION	448771	GSVSEDNsEDEISNL		enzymatic activity, inhibited				1938	1	41	3		
MKK6	EC 2.7.12.2; KINASE; Kinase, protein; Protein kinase, STE; Protein kinase, dual-specificity	P52564	5608	MAP2K6	17q24.3	human	S207	PHOSPHORYLATION	448194	ISGYLVDsVAKTIDA	Pkinase	enzymatic activity, induced	transcription, induced			715	11	9	46		
HDAC7	EC 3.5.1.98; Hydrolase	Q8C2B3	56233	Hdac7		mouse	S479	PHOSPHORYLATION	452459	RPLSRTQsSPAAPVS		molecular association, regulation		14-3-3 epsilon(DISRUPTS)		4281702	6	9	56		
Ets-1	DNA binding protein; Motility/polarity/chemotaxis; Transcription factor	P14921	2113	ETS1	11q23.3	human	S257	PHOSPHORYLATION	449319	DSFESIEsYDSCDRL		molecular association, regulation; activity, inhibited	transcription, inhibited		DNA(DISRUPTS)	2182	2	0	0		
Ebp1	Nuclear receptor co-regulator; Transcription, coactivator/corepressor	Q9UQ80	5036	PA2G4	12q13.2	human	S360	PHOSPHORYLATION	478276	ELKALLQsSASRKTQ	TraC	molecular association, regulation; protein stabilization; intracellular localization	apoptosis, inhibited; cell growth, altered	NPM1(INDUCES); Akt1(INDUCES)		1172815; 11148; 9580	4	1	0	in cells stimulated with EGF;   sumoylation of NPM K263 and K230 is required for the association between NPM and PA2G4 and distribution of PA2G4 in cells; detected in mitotic cells, but not in interphase cells; phosphorylation of this site protects PA2G4 (aka Ebp1) from apoptotic degradation and promotes cell survival	
AID	EC 3.5.4.5; Hydrolase	Q9GZX7	57379	AICDA	12p13	human	T27	PHOSPHORYLATION	471423	WAKGRREtYLCYVVK	APOBEC_N	enzymatic activity, inhibited; enzymatic activity, induced				21655809; 9140	5	2	0	class switch recombinaton	
GTF2I iso2	DNA binding protein; Transcription, coactivator/corepressor	P78347-2	2969	GTF2I	7q11.23	human	Y611	PHOSPHORYLATION	448253	KPELVISyLPPGMAS			cell cycle regulation; transcription, induced; transcription, altered			8846; 1720	2	0	0		
CLCN3	Channel, chloride; Membrane protein, integral; Membrane protein, multi-pass; Vesicle protein	P51790	1182	CLCN3	4q33	human	S109	PHOSPHORYLATION	451427	ERHRRINsKKKESAW		activity, inhibited				3628	2	0	0	Mutant S51A did not show an increase in chloride current after introduction of CAMKII, as seen in wild-type. 	
ZO1	Adaptor/scaffold; Motility/polarity/chemotaxis	Q07157	7082	TJP1	15q13	human	S168	PHOSPHORYLATION	470469	ASRERSLsPRSDRRS		molecular association, regulation; intracellular localization		ITGA5(INDUCES)		9201025	2	9	10		
NFkB-p105	DNA binding protein; Transcription factor	P19838	4790	NFKB1	4q24	human	S20	PHOSPHORYLATION	18751700	QMFHLDPsLTHTIFN		molecular association, regulation			DNA(INDUCES)	18378514	1	0	0		
tau iso8	Cytoskeletal protein	P10636-8	4137	MAPT	17q21.1	human	T217	PHOSPHORYLATION	449078	SRTPSLPtPPTREPK		O-GlcNAc glycosylation; intracellular localization	cytoskeletal reorganization			2587205; 17630402; 8165400	19	18	6	hyperphosphorylation of this site decreases O-GlcNAcylation of tau ; decreases rate of microtubule assembly; Phosphotylated sites found in the somato-dendritic campartment but not in the axon, where tau was not phosphorylated (T205 and T217),  or not simultaneously phosphorylated (T231 and 235). 	
BARD1	EC 6.3.2.-; EC 6.3.2.19; Ligase; Tumor suppressor; UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase	Q99728	580	BARD1	2q34-q35	human	T299	PHOSPHORYLATION	455768	KSRNEVVtPEKVCKN			cell cycle regulation			5849	2	5	13	resistance to genotoxic stress (mitomycin C)	
AR	DNA binding protein; Nuclear receptor; Transcription factor	P10275	367	AR	Xq12	human	S578	PHOSPHORYLATION	4275600	YGALTCGsCKVFFKR	zf-C4	molecular association, regulation; intracellular localization	transcription, induced	Ku70(DISRUPTS); Ku80(DISRUPTS)		4264907	2	0	0		
Huntingtin	Cytoskeletal protein	P42859	15194	Htt		mouse	S1179	PHOSPHORYLATION	465620	EQASTPMsPKKVGEA			apoptosis, inhibited			12086	2	9	2		
AurB	EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor)	Q96GD4	9212	AURKB	17p13.1	human	T232	PHOSPHORYLATION	450325	APSLRRKtMCGTLDY	Pkinase	intracellular localization; enzymatic activity, induced	cytoskeletal reorganization	INCENP(INDUCES)		14146312; 7550805; 3020	16	8	71	kinetochore-microtubule attachment ; T232-P is localized at midbody during telophase, and dephosphorylation which correlates with microtubule dissasembly,  may regulate abscission.	
EZH2	EC 2.1.1.43; METHYLTRANSFERASE; Methyltransferase; Methyltransferase, protein lysine; Oncoprotein	Q15910	2146	EZH2	7q35-q36	human	S21	PHOSPHORYLATION	457606	CWRKRVKsEYMRLRQ		molecular association, regulation; enzymatic activity, inhibited		H3(DISRUPTS)		6987	1	0	1	Phosphorylation suppresses trimethylation of Histone H3's trimethylation on K27.  Enzymatic inhibition through a decreased affinity towards H3.	
Cot	EC 2.7.11.25; KINASE; Kinase, protein; Protein kinase, STE; Protein kinase, Ser/Thr (non-receptor)	Q07174	26410	Map3k8		mouse	T290	PHOSPHORYLATION	455276	LPKDLRGtEIYMSPE	Pkinase	enzymatic activity, induced				5774	5	0	0		
AR	DNA binding protein; Nuclear receptor; Transcription factor	P10275	367	AR	Xq12	human	S791	PHOSPHORYLATION	448415	CVRMRHLsQEFGWLQ	Hormone_recep	intracellular localization	cell growth, inhibited; apoptosis, induced; apoptosis, inhibited; transcription, altered			2855907; 28722432	5	0	0	 low S791 phosphorylation was associated AR gene amplification; Mutation reduces transport to the nucleus. S213A and S791A mutations reduce  binding to androgen. 	
Rb-like 2	Transcription, coactivator/corepressor	Q08999	5934	RBL2	16q12.2	human	S1080	PHOSPHORYLATION	449741	IFYYFSNsPSKRLRE		molecular association, regulation; intracellular localization	cell cycle regulation	KPNA1(DISRUPTS); E2F4(DISRUPTS)		1200; 5981; 15571608	4	3	0		
eIF2-alpha	Translation; Translation initiation	P05198	1965	EIF2S1	14q23.3	human	S49	PHOSPHORYLATION	450210	IEGMILLsELSRRRI	S1	molecular association, regulation	translation, altered	eIF2-beta(INDUCES); PERK(INDUCES)		7290	4	1	0		
PPAR-alpha	DNA binding protein; Nuclear receptor	Q07869	5465	PPARA	22q13.31	human	S21	PHOSPHORYLATION	1789803	LEAGDLEsPLSEEFL			transcription, inhibited			18021032; 1713131	3	0	0		
Bcl-2	Apoptosis; Autophagy; Membrane protein, integral	P10415	596	BCL2	18q21.3	human	S70	PHOSPHORYLATION	448395	RDPVARTsPLQTPAA		molecular association, regulation; intracellular localization; activity, inhibited	apoptosis, altered; apoptosis, induced; apoptosis, inhibited; cell growth, altered	beclin 1(DISRUPTS); Bax(INDUCES); p53(DISRUPTS)		3342602; 2653909; 5288; 5371; 469; 5877; 4647112; 4313608; 6115915; 2403300; 6331303; 4522	35	1	0		
LAT	Adaptor/scaffold; Membrane protein, integral	O43561	27040	LAT	16p11.2	human	Y200	PHOSPHORYLATION	448004	SMESIDDyVNVPESG		activity, induced; molecular association, regulation	cytoskeletal reorganization; transcription, induced; transcription, altered	SLP76(INDUCES); PLCG1(INDUCES); GADS(INDUCES); Grb2(INDUCES)		8611; 5955628; 14987302	13	0	17	NF-AT mediated transcription; Does not regulate integrin mediated adhesion.; association of LAT-rich vesicles with surface clusters of  SLP76	
Crk	Adaptor/scaffold; Motility/polarity/chemotaxis	Q04929	417553	CRK		chicken	Y222	PHOSPHORYLATION	447951	GGPEPGPyAQPSINT		molecular association, regulation; protein conformation	cell differentiation, altered; cell adhesion, altered	PXN(DISRUPTS); Abl(DISRUPTS); Abl iso2(DISRUPTS)		2664100; 2049	19	9	1142		
SRC-3	ACETYLTRANSFERASE; Acetyltransferase; EC 2.3.1.48; Motility/polarity/chemotaxis; Nuclear receptor co-regulator; Transcription, coactivator/corepressor	Q9Y6Q9	8202	NCOA3	20q12	human	S867	PHOSPHORYLATION	454107	SPVSVGSsPPVKNIS		molecular association, regulation		ER-alpha(DISRUPTS)		4214	4	2	0	Mutations to alanine inhibited protein-protein interactions. 	
MSK1	EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor)	Q8C050	73086	Rps6ka5		mouse	T764	PHOSPHORYLATION	471413	LSSNPLMtPDILGSS		phosphorylation; enzymatic activity, induced				9060	1	3	15	T645 phosphorylation	
TELO2	Adaptor/scaffold	Q9Y4R8	9894	TELO2	16p13.3	human	S491	PHOSPHORYLATION	15668106	GSDSDLDsDDEFVPY		molecular association, regulation		PIH1D1(INDUCES)		15562522	2	0	0	this interaction (as a part of R2TP/prefoldin-like complex) is important for mTor and Smg1 stability	
SF3B1	RNA binding protein; RNA splicing; Spliceosome	O75533	23451	SF3B1	2q33.1	human	T244	PHOSPHORYLATION	455541	GRAKGSEtPGATPGS	SF3b1	molecular association, regulation		NIPP-1(INDUCES)		5421	1	15	3		
Rb-like 2	Transcription, coactivator/corepressor	Q08999	5934	RBL2	16q12.2	human	S948	PHOSPHORYLATION	449731	SGSSDSRsHQNSPTE	RB_B; BCS1_N	molecular association, regulation	cell cycle regulation	E2F4(DISRUPTS)		1200	2	6	0		
MUC1	Actin binding protein; Cell adhesion; Membrane protein, integral; Motility/polarity/chemotaxis; Nuclear receptor co-regulator	P15941	4582	MUC1	1q21	human	T1224	PHOSPHORYLATION	455682	RYVPPSStDRSPYEK		molecular association, regulation	cell growth, altered			5688	1	1	3		
ATR	EC 2.7.11.1; KINASE; Kinase, lipid; Kinase, protein; Membrane protein, integral; Protein kinase, ATYPICAL; Protein kinase, Ser/Thr (non-receptor)	Q9JKK8	245000	Atr		mouse	S431	PHOSPHORYLATION	456320	SGNNDEVsPKRRKLS		enzymatic activity, induced				6115922	8	6	1		
DAB1 iso2	Adaptor/scaffold	P97318-2	13131	Dab1		mouse	S550	PHOSPHORYLATION	479424	EPSGDNIsPQDGS__		phosphorylation				11449	1	0	0	inhibits tyrosine phosphorylation	
ITGB2	Cell adhesion; Cell surface; Membrane protein, integral; Motility/polarity/chemotaxis; Receptor, misc.	P11835	16414	Itgb2		mouse	T760	PHOSPHORYLATION	448533	NPLFKSAtTTVMNPK			cell motility, induced; cell adhesion, induced			28722117	6	2	4	T-cell homing to lymphocytes	
CTLA-4	Immunoglobulin superfamily; Membrane protein, integral	P16410	1493	CTLA4	2q33	human	Y201	PHOSPHORYLATION	450897	SPLTTGVyVKMPPTE		molecular association, regulation; intracellular localization		SHP-1(INDUCES)		5955629; 8405	4	0	1		
PPM1J	EC 3.1.3.16; Protein phosphatase, Ser/Thr (non-receptor)	Q149T7	71887	Ppm1j		mouse	S92	PHOSPHORYLATION	2846507	HAGRAVQsPPDTGRR		enzymatic activity, inhibited; protein conformation				2831790	1	0	0		
Cdc34	EC 6.3.2.19; Ligase; UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase	P49427	997	CDC34	19p13.3	human	S203	PHOSPHORYLATION	448687	APAPDEGsDLFYDDY		intracellular localization				1868	2	0	0		
PLD2	EC 3.1.4.4; Lipid Metabolism - ether lipid; Lipid Metabolism - glycerophospholipid; Motility/polarity/chemotaxis; Phospholipase	O14939	5338	PLD2	17p13.1	human	S134	PHOSPHORYLATION	456492	ARFAVAYsPARDAGN	PX	enzymatic activity, induced				3309503	2	2	0	stimulates EGF-dependent insulin secretion in pancreatic beta-cells	
ILK	EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, Ser/Thr (non-receptor); Protein kinase, TKL	Q13418	3611	ILK	11p15.4	human	S343	PHOSPHORYLATION	448495	SMADVKFsFQCPGRM	Pkinase_Tyr	molecular association, regulation		Akt1(INDUCES)		1127	3	0	1		
NPY1R	GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR	P21555	29358	Npy1r		rat	S352	PHOSPHORYLATION	455138	DYETIAMsTMHTDVS		receptor desensitization, altered; receptor internalization, altered				4358	1	0	0	may be an artifact of the truncation mutants	
DEK	DNA binding protein; DNA replication; Histone-binding protein; RNA splicing	P35659	7913	DEK	6p22.3	human	S19	PHOSPHORYLATION	465615	GTPTQPAsEKEPEMP		molecular association, regulation	RNA splicing, altered	U2AF1(INDUCES)		8094	1	1	0		
MAPKAPK2	EC 2.7.1.-; EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, CAMK; Protein kinase, Ser/Thr (non-receptor)	P49137	9261	MAPKAPK2	1q32	human	T222	PHOSPHORYLATION	448269	TSHNSLTtPCYTPYY	Pkinase	activity, induced				812	11	1	39		
Kv1.2	Channel, potassium; Membrane protein, integral; Membrane protein, multi-pass	P63142	25468	Kcna2		rat	S449	PHOSPHORYLATION	1818102	PDLKKSRsASTISKS		intracellular localization; phosphorylation				1713111	2	2	1	reduces phosphorylation on S440/S441	
YAP1 iso2	Transcription, coactivator/corepressor	P46937-2	10413	YAP1	11q13	human	S387	PHOSPHORYLATION	3190675	ESTDSGLsMSSYSVP		ubiquitination		BTRC(INDUCES)		13320408	1	1	0		
PPP2CA	EC 3.1.3.16; Motility/polarity/chemotaxis; PHOSPHATASE; Protein phosphatase, Ser/Thr (non-receptor)	P63330	19052	Ppp2ca		mouse	Y307	PHOSPHORYLATION	448571	VTRRTPDyFL_____		enzymatic activity, inhibited				1968339	40	0	0		
FAK	EC 2.7.1.112; EC 2.7.10.2; KINASE; Kinase, protein; Protein kinase, TK; Protein kinase, tyrosine (non-receptor)	Q05397	5747	PTK2	8q24.3	human	Y861	PHOSPHORYLATION	447965	PIGNQHIyQPVGKPD		activity, induced; molecular association, regulation; intracellular localization; phosphorylation	apoptosis, altered; cytoskeletal reorganization; cell adhesion, altered; cell growth, altered	P130Cas(INDUCES); ITGB5(INDUCES)		2872; 5401; 1926908; 6115915; 4894707; 5930; 5912	59	12	286		
AS160	GTPase activating protein, Rab	Q8BYJ6	210789	Tbc1d4		mouse	T649	PHOSPHORYLATION	455921	QFRRRAHtFSHPPSS		intracellular localization; phosphorylation				11999209; 11390405	23	10	119	AS160 T649 concentrated at plasma membrane, in different pool than AS160 S595; TBC1D4 S318/S588/T642/S751A mutation decreases phosphorylation of S711	
PELP1	Nuclear receptor co-regulator; Transcription, coactivator/corepressor	Q8IZL8	27043	PELP1	17p13.2	human	S991	PHOSPHORYLATION	15334104	PALPPPEsPPKVQPE			cell cycle regulation; carcinogenesis, altered; transcription, altered			15278800	1	0	0		
PTP-PEST	EC 3.1.3.48; Motility/polarity/chemotaxis; PHOSPHATASE; Protein phosphatase, tyrosine (non-receptor)	Q05209	5782	PTPN12	7q11.23	human	S39	PHOSPHORYLATION	451311	FMRLRRLsTKYRTEK		activity, inhibited				3511	3	0	15		
KOR-3	GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR	P35370	29256	Oprl1		rat	S334	PHOSPHORYLATION	456132	FRKFCCAsSLHREMQ		activity, induced; receptor desensitization, altered				6604	1	0	0		
Chk2	EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, CAMK; Protein kinase, Ser/Thr (non-receptor)	O96017	11200	CHEK2	22q12.1	human	S140	PHOSPHORYLATION	6339800	TDKYRTYsKKHFRIF	FHA	protein conformation; enzymatic activity, induced		PLK1(INDUCES)		6328010	1	0	0	dimerization and activation of of Chk2	
AurB	EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor)	Q9N0X0	396955	AURKB		pig	T232	PHOSPHORYLATION	450325	APSLRRKtMCGTLDY	Pkinase	enzymatic activity, induced				7961	16	8	71		
ENG	Membrane protein, integral; Motility/polarity/chemotaxis; Receptor, misc.	P17813	2022	ENG	9q34.11	human	S635	PHOSPHORYLATION	465619	AVAAPASsESSSTNH	DUF4199	phosphorylation				8075	1	1	0	required for threonine phosphorylation of ENG	
CARD9	Adaptor/scaffold	Q9H257	64170	CARD9	9q34.3	human	T531	PHOSPHORYLATION	1206001	NTTGSDNtDTEGS__		activity, inhibited				1172811	1	1	0	impairs ability of CARD9 to activate NF-kB 	
HIF2A	DNA binding protein; Transcription factor	P97481	13819	Epas1		mouse	S834	PHOSPHORYLATION	2085802	ASRLLGPsFEPYLLP			transcription, inhibited			3526	1	0	0		
AQP0	Channel, misc.; Membrane protein, integral; Membrane protein, multi-pass	P30301	4284	MIP	12q13	human	S231	PHOSPHORYLATION	453399	FPRLKSIsERLSVLK		molecular association, regulation		calmodulin(DISRUPTS)		1713134	1	2	0		
CITED1	Nuclear receptor co-regulator	P97769	12705	Cited1		mouse	S69	PHOSPHORYLATION	27937111	TSSSGSTsPIGSPTA	CITED	intracellular localization	cell differentiation, induced			27780046	1	0	0	S63/64/65/67/69/73/79/80/84A mutation in CITED1 inhibits its translocation into the nucleus and osteoblasts differentiation	
ERK2	EC 2.7.11.24; KINASE; Kinase, protein; Protein kinase, CMGC; Protein kinase, Ser/Thr (non-receptor)	P28482	5594	MAPK1	22q11.21	human	T185	PHOSPHORYLATION	447593	HDHTGFLtEYVATRW	Pkinase; YukC	activity, induced; protein degradation; molecular association, regulation; intracellular localization; protein conformation; phosphorylation; enzymatic activity, induced	cell motility, induced; cell differentiation, induced; cell motility, altered; cytoskeletal reorganization; transcription, inhibited; cell growth, altered	TACE(INDUCES); GNB1(INDUCES); KSR(INDUCES)		30280005; 7397603; 902; 7119508; 4313628; 7674; 6121900; 3406; 7483320; 11975; 13354722; 6011114; 13872500; 5708; 3394329; 6842222; 22553505; 6926; 25725907; 4914001; 7550825; 3342623; 3394311; 5930044; 1172804	954	60	2332	 increase of RhoA and Cdc42 activity, motility, migration, and invasion	
NFAT4	DNA binding protein; Transcription factor	Q12968	4775	NFATC3	16q22.2	human	S165	PHOSPHORYLATION	448858	RESSLSPsPASSISS		intracellular localization	transcription, inhibited			2029	2	1	0		
Rb-like 2	Transcription, coactivator/corepressor	Q08999	5934	RBL2	16q12.2	human	S966	PHOSPHORYLATION	449734	DRTSRDSsPVMRSSS	RB_B; BCS1_N	molecular association, regulation	cell cycle regulation	E2F4(DISRUPTS)		1200	2	1	1		
Hrs	Adaptor/scaffold; Motility/polarity/chemotaxis	O14964	9146	HGS	17q25	human	Y329	PHOSPHORYLATION	450191	IDPELARyLNRNYWE		intracellular localization; receptor recycling, altered; phosphorylation				2853; 9129	2	8	158	Hrs phosphorylation mutant Y329,334F is unable to degrade ubiquinated EGFR.   ; Cbl expression alters Hrs phosphorylation and fractionation in membrane and cyosokic fractions. 	
Rad52	DNA repair	P43351	5893	RAD52	12p13-p12.2	human	Y104	PHOSPHORYLATION	449061	DLNNGKFyVGVCAFV	Rad52_Rad22	activity, induced; molecular association, regulation; intracellular localization			DNA(INDUCES)	22354423; 2099	2	0	0	enhances ssDNA annealing activity by attenuating dsDNA binding.	
ELF4	DNA binding protein; Transcription factor	Q99607	2000	ELF4	Xq26	human	S641	PHOSPHORYLATION	463812	SGSLLTRsPTPAPFS		protein degradation				7869	2	2	1		
YY1	C2H2-type zinc finger protein; Cell development/differentiation; Transcription factor	P25490	7528	YY1	14q	human	S180	PHOSPHORYLATION	27276103	KKGGGKKsGKKSYLS		molecular association, regulation			DNA(INDUCES)	27257061	1	0	0		
CCND1	Activator protein; Nuclear receptor co-regulator	P24385	595	CCND1	11q13	human	T288	PHOSPHORYLATION	451435	VDLACTPtDVRDVDI		protein degradation; intracellular localization				1465; 2582601	5	0	0		
PLCL1	Phospholipase	Q15111	5334	PLCL1	2q33	human	T246	PHOSPHORYLATION	467202	PRFMWLKtVFEAADV		molecular association, regulation		PPP1CA(INDUCES)		8165	1	0	0		
SF2	RNA binding protein; RNA splicing; Spliceosome	NP_001103022	689890	Sfrs1		rat	S238	PHOSPHORYLATION	468705	SRGSPRYsPRHSRSR	Corona_nucleoca; DUF1509; DUF1777	intracellular localization				5007900	1	22	16	inhibits tau exon 10 inclusion, and increases 3R-tau production 	
LAT	Adaptor/scaffold; Membrane protein, integral	O54957	16797	Lat		mouse	Y195	PHOSPHORYLATION	448005	SLDGSREyVNVSPEQ		intracellular localization; phosphorylation	cell adhesion, altered	Fyn(INDUCES)		4228; 970001; 5299	22	2	38	Localization of recruited  PLCG2 to the membrane/cytoskeleton;  Fyn may be involved in LAT phosphorylation.	
HMGA1	DNA binding protein	Q8K585	117062	Hmga1		rat	S44	PHOSPHORYLATION	479856	PGTALVGsQKEPSEV		molecular association, regulation			DNA(DISRUPTS)	8553	2	17	14		
Cdc25B iso2	EC 3.1.3.48; Motility/polarity/chemotaxis; Nuclear receptor co-regulator; PHOSPHATASE; Protein phosphatase, dual-specificity	P30305-2	994	CDC25B	20p13	human	S101	PHOSPHORYLATION	9819902	DAGLCMDsPSPMDPH	M-inducer_phosp	protein degradation	cell cycle regulation			9721220	2	0	0		
FAK	EC 2.7.1.112; EC 2.7.10.2; KINASE; Kinase, protein; Protein kinase, TK; Protein kinase, tyrosine (non-receptor)	Q00944	396416	PTK2		chicken	Y863	PHOSPHORYLATION	447965	PAGNQHIyQPVGKPD		activity, induced; phosphorylation; enzymatic activity, induced				2577; 1087	59	12	286		
IGF1R	EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Protein kinase, TK; Protein kinase, tyrosine (receptor)	P08069	3480	IGF1R	15q26.3	human	Y1165	PHOSPHORYLATION	448387	RDIYETDyYRKGGKG	Pkinase_Tyr	protein conformation; enzymatic activity, induced				2407108; 7397608	11	28	697	in vitro	
Smad3	DNA binding protein; Nuclear receptor co-regulator; Transcription factor	P84022	4088	SMAD3	15q22.33	human	S204	PHOSPHORYLATION	451178	NHSMDAGsPNLSPNP		molecular association, regulation; intracellular localization; activity, inhibited	transcription, inhibited; signaling pathway regulation; transcription, altered; cell growth, altered	TGFBR1(INDUCES)		5262; 6945; 15658700; 3386; 15331010	11	0	0		
DLG1	Adaptor/scaffold; Motility/polarity/chemotaxis	Q12959	1739	DLG1	3q29	human	S158	PHOSPHORYLATION	2024309	FVSHSHIsPIKPTEA	MAGUK_N_PEST	protein degradation; protein stabilization; ubiquitination; intracellular localization				7549222; 5930023	3	4	0	degraded by HPV E6 oncoprotein in HPV-containing cell lines	
Shc1 iso2	Adaptor/scaffold; Apoptosis; Mitochondrial; Motility/polarity/chemotaxis	P98083-2	20416	Shc1		mouse	Y313	PHOSPHORYLATION	448511	ELFDDPSyVNIQNLD		molecular association, regulation; phosphorylation	cell motility, induced; cell motility, altered; apoptosis, inhibited	Grb2(INDUCES)		27519622; 2195488	36	61	1965	 required for ErbB2- and TGFB mediated tumor metastasis to the lungs.; metastatic spread of tumors; required for migration and invasion of ERB2-expressing cells	
Sam68	RNA binding protein	Q60749	20218	Khdrbs1		mouse	Y440	PHOSPHORYLATION	456716	GAYREHPyGRY____		intracellular localization				6872	1	0	11		
MST1	Autophagy; EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, STE; Protein kinase, Ser/Thr (non-receptor)	Q13043	6789	STK4	20q11.2-q13.2	human	S82	PHOSPHORYLATION	12057400	SIMQQCDsPHVVKYY	Pkinase	molecular association, regulation; intracellular localization; enzymatic activity, induced	apoptosis, altered	MST1(INDUCES)		12021305	1	0	0		
Ikaros	C2H2-type zinc finger protein; DNA binding protein; Transcription factor	Q03267	22778	Ikzf1		mouse	S293	PHOSPHORYLATION	4828302	LSDMPYDsANYEKED		molecular association, regulation; intracellular localization			DNA(DISRUPTS)	4615812	1	1	4		
tensin 3	Adaptor/scaffold; Motility/polarity/chemotaxis	Q68CZ2	64759	TNS3	7p12.3	human	Y1206	PHOSPHORYLATION	9824601	SHSFRGAyGLAMKVA	SH2	molecular association, regulation	cell motility, altered; cell growth, altered	P130Cas(INDUCES); Sam68(INDUCES); FAK(INDUCES)		9775901	1	0	0	contributes to tumorigenesis and metastasis	
MST2	Autophagy; EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, STE; Protein kinase, Ser/Thr (non-receptor)	Q13188	6788	STK3	8q22.2	human	T117	PHOSPHORYLATION	12615900	IIRLRNKtLIEDEIA	Pkinase	molecular association, regulation; intracellular localization; enzymatic activity, inhibited; phosphorylation	carcinogenesis, induced; apoptosis, altered; signaling pathway regulation; cell growth, altered	RASSF1(DISRUPTS); MST2(DISRUPTS); RAF1(INDUCES)		12558730; 13371800	2	0	1	inhibits MST2 T180 autophosphorylation 	
Titin	EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, CAMK; Protein kinase, Ser/Thr (non-receptor)	Q8WZ42	7273	TTN	2q31	human	Y32341	PHOSPHORYLATION	448692	LFTAPEYyAPEVHQH	Pkinase	enzymatic activity, induced				1869	1	0	0		
p63	DNA binding protein; Transcription factor	Q9H3D4	8626	TP63	3q28	human	S479	PHOSPHORYLATION	4668107	MNKLPSVsQLINPQQ		protein degradation				4659601	2	1	0		
STMN1	Cytoskeletal protein	P54227	16765	Stmn1		mouse	S38	PHOSPHORYLATION	448556	SVPDFPLsPPKKKDL	Stathmin	phosphorylation				15022720	34	62	150	S38A mutation reduces phosphorylation of STMN1 S25 	
TRPC3	Channel, cation; Membrane protein, integral; Membrane protein, multi-pass	Q13507	7222	TRPC3		human	S700	PHOSPHORYLATION	454431	PPFSLVPsPKSFVYF		activity, inhibited				7387; 4290	2	0	0		
FOXO1A	DNA binding protein; Nuclear receptor co-regulator; Transcription factor	Q12778	2308	FOXO1	13q14.1	human	S319	PHOSPHORYLATION	449113	TFRPRTSsNASTISG		intracellular localization	apoptosis, altered; transcription, altered; transcription, inhibited			6791; 6115915; 4904514; 2463200; 12525214; 3405	20	3	18		
RPS3	Apoptosis; Ribosomal protein; Translation	P23396	6188	RPS3	11q13.3-q13.5	human	R67	DI-METHYLATION	9184303	GEKGRRIrELTAVVQ	KH_2	intracellular localization				8164811	1	0	0	regulates ribosome assembly	
NR5A2	DNA binding protein; Nuclear receptor; Transcription factor	O00482	2494	NR5A2	1q32.1	human	S510	PHOSPHORYLATION	456465	LPEIRAIsMQAEEYL	Hormone_recep	activity, induced	transcription, induced			6725	1	0	0		
STMN2	Cytoskeletal protein	P21818	84510	Stmn2		rat	S73	PHOSPHORYLATION	450173	EAPRTLAsPKKKDLS	Stathmin; CDC37_N		cytoskeletal reorganization			5546	5	0	0		
DDX5	EC 3.6.1.-; EC 3.6.4.13; Helicase; Nuclear receptor co-regulator; RNA binding protein; RNA splicing; Spliceosome	P17844	1655	DDX5	17q21	human	Y593	PHOSPHORYLATION	470084	NGMNQQAyAYPATAA		molecular association, regulation	apoptosis, inhibited; cytoskeletal reorganization	CTNNB1(INDUCES)		9627; 8971	3	2	1		
Smad3	DNA binding protein; Nuclear receptor co-regulator; Transcription factor	P84022	4088	SMAD3	15q22.33	human	T388	PHOSPHORYLATION	1243500	GAEYRRQtVTSTPCW	MH2	molecular association, regulation	transcription, inhibited	TUBB2B(INDUCES)		26350300	2	0	0	cGMP-induced inhibition of SERPINE1 transcriptional activity  	
CDK2	EC 2.7.11.22; KINASE; Kinase, protein; Protein kinase, CMGC; Protein kinase, Ser/Thr (non-receptor)	P24941	1017	CDK2	12q13	human	T39	PHOSPHORYLATION	2712201	LKKIRLDtETEGVPS	Pkinase	intracellular localization	cell cycle regulation; apoptosis, induced			2704310	1	1	0	contributes to the cell death induced by methotrexate and docetaxel	
SLC1A6	Membrane protein, integral; Membrane protein, multi-pass; Transporter	O35921	84012	Slc1a6		rat	T40	PHOSPHORYLATION	480172	RTRLRLQtMTREHVR		intracellular localization				11485	1	0	0		
Cdc42 iso1	G protein; G protein, monomeric, Rho; Motility/polarity/chemotaxis	P60953-1	998	CDC42	1p36.1	human	Y64	PHOSPHORYLATION	450272	DTAGQEDyDRLRPLS	Ras	activity, induced; molecular association, regulation	cell growth, altered	RhoGDI alpha(INDUCES)		2978	1	1	28	Cdc42 Y64A mutant is impaired in transforming NIH 3T3 cells.  	
RhoGDI beta	Cell adhesion; G protein regulator, misc.; Motility/polarity/chemotaxis	P52566	397	ARHGDIB	12p12.3	human	Y24	PHOSPHORYLATION	448978	ELDSKLNyKPPPQKS	Rho_GDI	molecular association, regulation		RAC1(DISRUPTS)		7313806	2	5	363		
Abl	EC 2.7.1.112; EC 2.7.10.2; KINASE; Kinase, protein; Protein kinase, TK; Protein kinase, tyrosine (non-receptor)	P00519	25	ABL1	9q34.1	human	Y253	PHOSPHORYLATION	450301	HKLGGGQyGEVYEGV	Pkinase_Tyr	enzymatic activity, induced				6011117	3	7	279	SH2 and catalytic domains of Fes and Abl interact with ligand, stimulating kinase activity. 	
LRRK1	EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, Ser/Thr (non-receptor); Protein kinase, TKL	Q38SD2	79705	LRRK1	15q26.3	human	Y971	PHOSPHORYLATION	23303206	TQQTEEQyFQFLAKF		enzymatic activity, inhibited	endocytosis, altered			23260300	1	0	0	regulates endosomal trafficking of EGFR	
PKCZ	EC 2.7.11.13; KINASE; Kinase, protein; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor)	Q05513	5590	PRKCZ	1p36.33-p36.2	human	Y428	PHOSPHORYLATION	482866	EILRGEEyGFSVDWW	Pkinase	protein conformation				11758	1	0	0		
Snail2	Apoptosis; C2H2-type zinc finger protein; Motility/polarity/chemotaxis; Transcription factor	O43623	6591	SNAI2	8q11	human	S100	PHOSPHORYLATION	25603907	DTSSKDHsGSESPIS	Rpr2	protein degradation; intracellular localization	transcription, induced			25582516	1	0	0	transcriptional activity of E-cadherin;  WT localized in nucleus and cytoplasm, mutants localize in nucleus;  mutants enhance epithelial-mesenchymal transition (EMT)	
DGKA	EC 2.7.1.107; Kinase, lipid; Lipid Metabolism - glycerolipid; Lipid Metabolism - glycerophospholipid; Motility/polarity/chemotaxis	O88673	13139	Dgka		mouse	Y336	PHOSPHORYLATION	486452	ILPPCSIyPSVLVSG		intracellular localization				1172810	4	0	0	translocates to the plasma membrane after stimulation of endogenous T cell receptor (TCR) with anti-CD3/C28	
CDH5	Cell adhesion; Membrane protein, integral; Motility/polarity/chemotaxis	P33151	1003	CDH5	16q22.1	human	Y685	PHOSPHORYLATION	455658	LDARPSLyAQVQKPP	Cadherin_C	molecular association, regulation		CSK(INDUCES)		2506301	4	2	155		
NFAT1	DNA binding protein; Transcription factor	Q60591	18019	Nfatc2		mouse	T116	PHOSPHORYLATION	455763	PSPRIEItPSHELMQ		activity, induced; molecular association, regulation	transcription, induced	PPP3CA(INDUCES)		5803	1	2	0		
mGluR5	GPCR, family 3; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR	P31424	24418	Grm5		rat	T840	PHOSPHORYLATION	450487	RSAFTTStVVRMHVG		receptor inactivation, altered; activity, inhibited				8640; 3051	2	4	2	T840A and truncated receptor mutations blunted GRK2 inhibition of mGluR5 signaling	
claudin 4	Cytoskeletal protein; Membrane protein, integral; Membrane protein, multi-pass	O14493	1364	CLDN4	7q11.23	human	Y208	PHOSPHORYLATION	451666	RSAAASNyV______		molecular association, regulation	cell adhesion, altered	ZO1(DISRUPTS)		6976	1	3	45	Phosphorylation of site increases paracellular permeability through tight junctions.	
ITGB4 iso2	Cell adhesion; Membrane protein, integral; Motility/polarity/chemotaxis; Receptor, misc.	P16144-2	3691	ITGB4	17q25	human	Y1440	PHOSPHORYLATION	450141	STTLPRDySTLTSVS		activity, induced; molecular association, regulation	cell motility, altered; cell adhesion, altered	Shc1(INDUCES)		2765; 17613013	2	9	126	promote SFK (Fyn) activation and tumor cell invasion	
GRF-1	GTPase activating protein, Rac/Rho; Motility/polarity/chemotaxis; Transcription factor	Q9NRY4	2909	ARHGAP35	19q13.3	human	T1226	PHOSPHORYLATION	7159800	LRSLRRNtKKPKPKP		molecular association, regulation; activity, inhibited	cytoskeletal reorganization			6804206; 10425112	2	0	1	prevents the association of the protein with acidic phospholipids and modulate the GTPase substrate preference	
SRF	Motility/polarity/chemotaxis; Transcription factor	P11831	6722	SRF	6p21.1	human	S253	PHOSPHORYLATION	13203801	LTYQVSEsDSSGETK			transcription, inhibited			12660602	1	0	0		
ADD1	Cytoskeletal protein; Motility/polarity/chemotaxis	P35611	118	ADD1	4p16.3	human	T445	PHOSPHORYLATION	449480	QKQQREKtRWLNSGR		activity, induced; intracellular localization	cytoskeletal reorganization			7097; 2220	3	0	0	Phosphorylation at T445 induced by STA2 translocated p-T445 into triton insoluble low speed fraction while p-S726 did not show any translocation of fractions.  This translocation was inhibited by Y27632.  ; phosphorylation of this site by Rho-kinase regulates membrane ruffling and cell motility.	
CCNB1	Activator protein; Cell cycle regulation	P14635	891	CCNB1	5q12	human	S133	PHOSPHORYLATION	448445	SPSPMETsGCAPAEE	Trypan_PARP	intracellular localization			DNA(INDUCES)	25573559; 1463; 12778806; 8415	6	1	0	S133-p is required for accelerated nuclear import.  ; The phosphorylation of S133 and S147 is necessary for the nuclear translocation of cyclin B1 during G2/M phase.; enhances nuclear import	
HDAC7	EC 3.5.1.98; Hydrolase	Q8WUI4	51564	HDAC7	12q13.1	human	S358	PHOSPHORYLATION	455621	WPLSRTRsEPLPPSA		intracellular localization	cell motility, altered; cytoskeletal reorganization; transcription, altered; cell growth, altered			7397635; 3886811; 5506	5	5	18	important for VEGF-induced aorta ring angiogenesis; nucleo-cytoplasmic shuttling	
MRE11A	Cell cycle regulation; DNA binding protein; DNA repair; Deoxyribonuclease	P49959	4361	MRE11A	11q21	human	T481	PHOSPHORYLATION	11506400	VKYQLEKtQRFLKER		molecular association, regulation			DNA(DISRUPTS)	11484420	1	0	0		
InsR	EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Protein kinase, TK; Protein kinase, tyrosine (receptor)	P06213	3643	INSR	19p13.3-p13.2	human	Y992	PHOSPHORYLATION	451597	DGPLGPLyASSNPEY		enzymatic activity, inhibited				2852622	3	0	0		
InsR iso2	EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Protein kinase, TK; Protein kinase, tyrosine (receptor)	P06213-2	3643	INSR	19p13.3-p13.2	human	Y1349	PHOSPHORYLATION	447684	SYEEHIPyTHMNGGK		activity, inhibited	cell cycle regulation			2652	14	5	13		
Akt1	EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor)	P31749	207	AKT1	14q32.32	human	Y326	PHOSPHORYLATION	447858	EVLEDNDyGRAVDWW	Pkinase	enzymatic activity, induced				15331019	3	2	25	Brk induces Akt activation by phosphorylation on Y315,Y326. 	
NEK11	EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor)	Q8NG66	79858	NEK11	3q22.1	human	S273	PHOSPHORYLATION	10433801	SMLNKNPsLRPSAIE	Pkinase	enzymatic activity, induced				10353922	1	0	0		
ISCU	Mitochondrial	Q9H1K1	23479	ISCU	12q24.1	human	S14	PHOSPHORYLATION	469833	FRLRRAAsALLLRSP		protein stabilization; molecular association, regulation		14-3-3 beta(INDUCES)		27775400; 21683737	2	29	83		
GH receptor	Membrane protein, integral; Receptor, cytokine	P16310	25235	Ghr		rat	Y594	PHOSPHORYLATION	450480	DAEPVPDyTTVHTVK	GHBP	molecular association, regulation		SHP-2(INDUCES)		3110	2	0	0	Major SHP-2 interacting phosphorylation site. GHR-bound SHP-2 negatively regulates GHR/JAK2 and STAT5B signaling.	
SRC-3	ACETYLTRANSFERASE; Acetyltransferase; EC 2.3.1.48; Motility/polarity/chemotaxis; Nuclear receptor co-regulator; Transcription, coactivator/corepressor	Q9Y6Q9	8202	NCOA3	20q12	human	S728	PHOSPHORYLATION	3217881	VVKQEQLsPKKKENN		intracellular localization				22723939	1	5	4	regulates SRC-3 access to condensed chromatin	
TPH2	Amino Acid Metabolism - tryptophan; EC 1.14.16.4; Oxidoreductase	Q8IWU9	121278	TPH2	12q21.1	human	S104	PHOSPHORYLATION	1033700	RKSRRRSsEVEIFVD	ACT	molecular association, regulation		14-3-3 epsilon(INDUCES); 14-3-3 gamma(INDUCES)		970070	1	4	1		
CTNNB1	Actin binding protein; Cell adhesion; Motility/polarity/chemotaxis; Nuclear receptor co-regulator; Transcription factor	P35222	1499	CTNNB1	3p21	human	S29	PHOSPHORYLATION	3075000	VSHWQQQsYLDSGIH		protein degradation	cell motility, altered	CTNNA1(INDUCES)		8383	3	1	4		
Oct7	DNA binding protein; Motility/polarity/chemotaxis; Transcription factor	P20265	5454	POU3F2	6q16	human	S360	PHOSPHORYLATION	486486	RKRKKRTsIEVSVKG	Homeobox		transcription, altered		DNA(DISRUPTS)	11792	2	0	0	Phosphorylation reduced binding to NORE and PORE, but not MORE motifs. 	
SLC22A1	Membrane protein, integral; Membrane protein, multi-pass; Transporter	Q63089	24904	Slc22a1		rat	S286	PHOSPHORYLATION	455610	YYWFVPEsPRWLLSQ	Sugar_tr	activity, induced				5524	1	0	0	stimulates ASP+ uptake	
PLCD1	Carbohydrate Metabolism - inositol phosphate; EC 3.1.4.11; Phospholipase	P10688		Plcd1		rat	S35	PHOSPHORYLATION	9993602	LLKVKSSsWRRERFY	PH	enzymatic activity, induced				9985924	1	0	0	in vitro	
REEP4	Membrane protein, integral; Membrane protein, multi-pass	Q9H6H4	80346	REEP4	8p21.3	human	S152	PHOSPHORYLATION	3212556	AGRLRSFsMQDLRSI		molecular association, regulation		14-3-3 beta(INDUCES)		21683737	1	26	93	mutation of this site prevents 14-3-3 binding (pan-14-3-3 antibody)	
JAK2	EC 2.7.10.2; KINASE; Kinase, protein; Protein kinase, TK; Protein kinase, tyrosine (non-receptor)	Q62689	24514	Jak2		rat	Y1008	PHOSPHORYLATION	448408	LPQDKEYyKVKEPGE	Pkinase_Tyr	enzymatic activity, induced				3645	44	1	16		
KRas iso2	G protein; G protein, monomeric, Ras; Motility/polarity/chemotaxis	P01116-2	3845	KRAS	12p12.1	human	S181	PHOSPHORYLATION	459210	GKKKKKKsKTKCVIM		molecular association, regulation; intracellular localization		calmodulin(DISRUPTS)		3548308; 7636	3	0	0		
NFkB-p65	DNA binding protein; Nuclear receptor co-regulator; Transcription factor	Q04206	5970	RELA	11q13	human	S276	PHOSPHORYLATION	447798	SMQLRRPsDRELSEP		activity, induced; protein stabilization; molecular association, regulation; intracellular localization	apoptosis, inhibited; transcription, induced; transcription, inhibited; transcription, altered	HDAC1(DISRUPTS); PKACA(INDUCES); p300(INDUCES); eEF1B(INDUCES); CBP(INDUCES)	DNA(INDUCES)	7397645; 11419362; 2629600; 3475702; 7206; 7124724; 4313619; 6026; 17613004; 4248200; 22881901; 1172828; 5309400; 15331013; 2621804; 1968305; 14821620	62	0	0		
TBK1	EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor)	Q9UHD2	29110	TBK1	12q14.1	human	S172	PHOSPHORYLATION	447732	EDDEQFVsLYGTEEY	Pkinase	enzymatic activity, induced	transcription, induced			1328; 22913906	5	2	42		
DDR1	EC 2.7.1.112; EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Protein kinase, TK; Protein kinase, tyrosine (receptor)	Q08345	780	DDR1	6p21.3	human	Y796	PHOSPHORYLATION	457957	RNLYAGDyYRVQGRA	Pkinase_Tyr	molecular association, regulation		SHP-2(INDUCES)		7860	1	9	945	required for the DDR1-mediated suppression of tyrosine phosphorylation of Stat1 and Stat3, cell migration, branching tubulogenesis	
NUMB	Cell development/differentiation; Tumor suppressor	Q2LC84	29419	Numb		rat	S275	PHOSPHORYLATION	456490	EQLARQGsFRGFPAL	NumbF	molecular association, regulation		AP2A1(DISRUPTS); AP2B1(DISRUPTS); 14-3-3 eta(INDUCES)		8928	4	1	7		
CDC7	EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor)	O00311	8317	CDC7	1p22	human	T376	PHOSPHORYLATION	2864203	QVAPRAGtPGFRAPE	Pkinase	enzymatic activity, induced				2852651	2	0	12		
G6PD iso3	Carbohydrate Metabolism - pentose phosphate pathway; Cell development/differentiation; EC 1.1.1.49; Other Amino Acids Metabolism - glutathione; Oxidoreductase	P11413-3	2539	G6PD	Xq28	human	T266	PHOSPHORYLATION	15207800	NIACVILtFKEPFGT	G6PD_C	enzymatic activity, induced				15026115	1	0	0		
NFAT1	DNA binding protein; Transcription factor	Q60591	18019	Nfatc2		mouse	S182	PHOSPHORYLATION	449625	GSSASFIsDTFSPYT			transcription, inhibited			1188	0	1	0		
CDK1	EC 2.7.11.22; EC 2.7.11.23; KINASE; Kinase, protein; Motility/polarity/chemotaxis; Protein kinase, CMGC; Protein kinase, Ser/Thr (non-receptor)	P06493	983	CDK1	10q21.1	human	T14	PHOSPHORYLATION	447608	IEKIGEGtYGVVYKG	Pkinase	enzymatic activity, inhibited	cell cycle regulation			7309812; 627; 4829209; 14654305; 7981800; 631; 5488	19	60	1661		
ARHGAP3	GTPase activating protein, Rac/Rho	P52757	1124	CHN2	7p15.3	human	S171	PHOSPHORYLATION	13790300	EKVSRRLsRSKNEPR		molecular association, regulation; intracellular localization; activity, inhibited	cell motility, altered	RAC1(NOT_REPORTED)		13354727	1	1	0		
coronin 1C	Actin binding protein; Motility/polarity/chemotaxis	Q9ULV4	23603	CORO1C	12q24.1	human	S463	PHOSPHORYLATION	22996300	CNQDERIsKLEQQMA			cell growth, inhibited; cell adhesion, induced; cytoskeletal reorganization; cell motility, inhibited			27619337; 22958932	2	0	0	decreased matrix degradation and invasion, increased invadopodia-like extensions in vitro	
WWOX	Apoptosis; EC 1.1.1.-; Oxidoreductase	Q91WL8	80707	Wwox		mouse	Y33	PHOSPHORYLATION	449043	TTKDGWVyYANHTEE	WW	molecular association, regulation	apoptosis, induced	ZFRA(INDUCES)		2856305	12	0	0		
LTB4R2	GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Motility/polarity/chemotaxis; Receptor, GPCR	Q9NPC1	56413	LTB4R2	14q11.2-q12	human	T355	PHOSPHORYLATION	12267086	GGRSREGtMELRTTP		molecular association, regulation	cell motility, induced	RANBP9(DISRUPTS)		21691003; 28722428	2	0	0		
STAT5B	DNA binding protein; Transcription factor	P51692	6777	STAT5B	17q11.2	human	Y699	PHOSPHORYLATION	448198	TAKAVDGyVKPQIKQ		activity, induced; molecular association, regulation	cell cycle regulation; transcription, induced; transcription, altered	Bcr(INDUCES); Hck(INDUCES)	DNA(INDUCES)	5410124; 4049500; 9052; 2452303; 3404200; 2704330; 1172807; 2018	30	22	2207		
p47phox	EC 1.-.-.-; Oxidoreductase	P14598	653361	NCF1	7q11.23	human	S315	PHOSPHORYLATION	451725	AHSIHQRsRKRLSQD		molecular association, regulation		CYBA(INDUCES)		8704	7	0	0		
TESK1	EC 2.7.12.1; KINASE; Kinase, protein; Protein kinase, Ser/Thr (non-receptor); Protein kinase, TKL	Q63572	29460	Tesk1		rat	S215	PHOSPHORYLATION	452045	EPLAVVGsPYWMAPE	Pkinase	enzymatic activity, induced				3988	1	0	0	in vitro assay	
CFTR	Channel, chloride; EC 3.6.3.49; Hydrolase; Membrane protein, integral; Membrane protein, multi-pass; Transporter	P13569	1080	CFTR	7q31.2	human	S686	PHOSPHORYLATION	449980	WTETKKQsFKQTGEF	CFTR_R	activity, induced				8384; 8371	4	0	0		
Deptor	Apoptosis	Q8TB45	64798	DEPTOR	8q24.12	human	S286	PHOSPHORYLATION	21697912	SSMSSCGsSGYFSSS		protein degradation; molecular association, regulation; ubiquitination		BTRC(INDUCES); FBW1B(INDUCES)		21699400; 21699401; 21683709	3	1	0		
GABRG2	Channel, chloride; Channel, ligand-gated; Membrane protein, integral; Membrane protein, multi-pass	Q6PW52	29709	Gabrg2		rat	S381	PHOSPHORYLATION	452033	NPLLRMFsFKAPTID	Neur_chan_memb	intracellular localization				4072	3	3	2		
RYR2	Channel, ligand-gated; Membrane protein, integral; Membrane protein, multi-pass	E9Q401	20191	Ryr2		mouse	S2807	PHOSPHORYLATION	448848	YNRTRRIsQTSQVSI		activity, induced; molecular association, regulation	exocytosis, altered	FKBP1B(DISRUPTS)		15331015; 26341723; 7437	24	2	3	calcium release, cardiomyopathy and increased mortality in mdx mice;  stress-induced cognitive dysfunction; RyR2 S2808A mutation in mice improves cardiac functions after myocardial infarction; Stress induced calcium leak in channels	
neurabin 1	Adaptor/scaffold; Protein phosphatase, regulatory subunit	O35867	84685	Ppp1r9a		rat	S461	PHOSPHORYLATION	455523	ANRKIKFsCAPIKVF		molecular association, regulation		p70S6K(INDUCES); PPP1CA(INDUCES)		5380	2	0	1		
Cbl-b	Adaptor/scaffold; Calcium-binding protein; EC 6.3.2.-; Ligase; UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase	Q13191	868	CBLB	3q13.11	human	Y665	PHOSPHORYLATION	451550	GHLGSEEyDVPPRLS		molecular association, regulation		CrkL(INDUCES)		12482227	2	2	121	in vitro and vivo;  Y709 is major binding site, and to lesser extent Y665	
SH2-B-beta	Adaptor/scaffold	Q62985-2	89817	Sh2b1		rat	Y494	PHOSPHORYLATION	448754	VHPLSTPyPPLDTPE			cell motility, induced; cytoskeletal reorganization			1921; 27619352	2	0	0	membrane ruffling; macrophage migration	
InsR	EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Protein kinase, TK; Protein kinase, tyrosine (receptor)	P06213	3643	INSR	19p13.3-p13.2	human	S1217	PHOSPHORYLATION	3103702	DGVFTTSsDMWSFGV	Pkinase_Tyr	enzymatic activity, induced				8572	1	0	0		
CCT2	Chaperone	P78371	10576	CCT2	12q15	human	S260	PHOSPHORYLATION	472352	GSRVRVDsTAKVAEI	Cpn60_TCP1		cell growth, altered			7313801	2	9	241	regulates cell proliferation	
MEGF10	Membrane protein, integral	Q96KG7	84466	MEGF10	5q33	human	Y1030	PHOSPHORYLATION	12186245	LSSSENPyATIKDPP			cell growth, induced			28723106	1	0	1		
myocardin	Cell development/differentiation; Transcription factor	Q8VIM5	214384	Myocd		mouse	T893	PHOSPHORYLATION	10791203	TMEWLDLtPPSSTPG		molecular association, regulation	transcription, inhibited	CBP(DISRUPTS)		10353931	1	0	0		
Cot	EC 2.7.11.25; KINASE; Kinase, protein; Protein kinase, STE; Protein kinase, Ser/Thr (non-receptor)	P41279	1326	MAP3K8	10p11.23	human	S400	PHOSPHORYLATION	447712	EDQPRCQsLDSALLE			transcription, altered			1314	2	1	0		
Bcl-2	Apoptosis; Autophagy; Membrane protein, integral	P10415	596	BCL2	18q21.3	human	T69	PHOSPHORYLATION	448398	SRDPVARtSPLQTPA		molecular association, regulation	apoptosis, altered; apoptosis, inhibited	beclin 1(DISRUPTS); Bax(INDUCES); p53(DISRUPTS)		4313608; 2653909; 5288; 2403300; 6331303	8	0	0		
HSF1	DNA binding protein; Transcription factor	Q00613	3297	HSF1	8q24.3	human	S303	PHOSPHORYLATION	449045	RVKEEPPsPPQSPRV	Vert_HS_TF	molecular association, regulation; intracellular localization; protein processing; activity, inhibited	transcription, inhibited; transcription, altered	14-3-3 epsilon(INDUCES); SUMO1(INDUCES)		7324127; 3027; 2080	11	26	5		
PINX1	Inhibitor protein	Q96BK5	54984	PINX1	8p23	human	T141	PHOSPHORYLATION	14823403	DLSSRSKtDLDCIFG		protein degradation; ubiquitination				14790317	1	1	0		
Bcl-2L12	Apoptosis	Q9HB09	83596	BCL2L12	19q13.3	human	S156	PHOSPHORYLATION	9258022	SESPRPCsLPIRPCY			apoptosis, inhibited			23260328	1	0	6		
VEGFR2	EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Protein kinase, TK; Protein kinase, tyrosine (receptor)	P35968	3791	KDR	4q11-q12	human	Y1059	PHOSPHORYLATION	447900	DIYKDPDyVRKGDAR	Pkinase_Tyr	molecular association, regulation; receptor internalization, altered; phosphorylation; enzymatic activity, induced	cell cycle regulation; cell differentiation, altered; cell growth, induced; cell growth, altered	Cbl(INDUCES); Src(INDUCES); PLCG1(INDUCES)		7119513; 2506305; 2855903; 2325; 6313; 2512009	15	2	105		
CPLX2	Vesicle protein	P84088	281711	CPLX2		cow	S115	PHOSPHORYLATION	474556	EEEEEEEsILDTVLK	Synaphin; FCP1_C; DDRGK	molecular association, regulation		STX1A(INDUCES)		9272	1	1	0	SNARE complex summarized by Syntaxin binding.	
Shc1	Adaptor/scaffold; Apoptosis; Mitochondrial; Motility/polarity/chemotaxis	P98083	20416	Shc1		mouse	S36	PHOSPHORYLATION	448508	TPPEELPsPSASSLG		intracellular localization; phosphorylation	apoptosis, altered; apoptosis, induced; transcription, altered			7667; 19084439; 9395; 6347; 2425235; 5930016	14	0	0	induced by cisplatin	
Dok1	Adaptor/scaffold; Motility/polarity/chemotaxis	P97465	13448	Dok1		mouse	Y361	PHOSPHORYLATION	448367	DSKEDPIyDEPEGLA		molecular association, regulation	cytoskeletal reorganization	RASA1(INDUCES); Nck1(INDUCES)		2630; 5869; 3789	7	22	510		
RAF1	EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, Ser/Thr (non-receptor); Protein kinase, TKL	P05625	396245	RAF1		chicken	S338	PHOSPHORYLATION	447742	RPRGQRDsSYYWEIE		intracellular localization; enzymatic activity, induced	apoptosis, inhibited			2941; 5487	73	2	6		
MYBPC3	Myosin binding protein	O70468	17868	Mybpc3		mouse	S302	PHOSPHORYLATION	471081	SLLKKRDsFRRDSKL		molecular association, regulation	apoptosis, altered; cytoskeletal reorganization	MYBPC1(DISRUPTS)		9008	15	3	0	The triple aspartic acid mutation shows greater distance between the two thick myosin filaments (affects the steric arrangement of the filament distances) in heart tissue.  Mutation is cardioprotective during stress (ischemia-reprofusion injury) against apoptosis similar to isoproterenol treatment.	
PIP4K2A	Carbohydrate Metabolism - inositol phosphate; EC 2.7.1.149; EC 2.7.1.68; Kinase, lipid; Motility/polarity/chemotaxis	P48426	5305	PIP4K2A	10p12.2	human	T376	PHOSPHORYLATION	460716	KAAHAAKtVKHGAGA	PIP5K	enzymatic activity, inhibited				7765	1	0	0		
ITGB1	Cell adhesion; Cell surface; Membrane protein, integral; Motility/polarity/chemotaxis; Receptor, misc.	P05556	3688	ITGB1	10p11.2	human	T788	PHOSPHORYLATION	448600	PIYKSAVtTVVNPKY	Integrin_b_cyt	activity, induced; protein conformation	cell motility, altered; cell adhesion, altered			6636; 6277008; 7459; 3222	9	1	1	regulates cell attachment and focal contact; induce vascular invasion; 
regulates expression of the 9EG7 epitope	
DAZAP1	Motility/polarity/chemotaxis; RNA binding protein	Q96EP5	26528	DAZAP1	19p13.3	human	T269	PHOSPHORYLATION	467204	FTSYIVStPPGGFPP		molecular association, regulation		DAZ1(DISRUPTS)		8163	1	0	0		
NFAT5	Transcription factor	Q9WV30	54446	Nfat5		mouse	S155	PHOSPHORYLATION	2715402	PEDLLDNsRMSCQDE		intracellular localization				27108301	3	3	2	regulates nuclear localization	
RAF1	EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, Ser/Thr (non-receptor); Protein kinase, TKL	Q99N57	110157	Raf1		mouse	Y341	PHOSPHORYLATION	447750	GQRDSSYyWEIEASE		phosphorylation; enzymatic activity, induced	apoptosis, altered			6534; 3340213; 1758	28	1	1	Bad Ser 112 + 136 phosphorylation	
SMRT	Nuclear receptor co-regulator; Transcription, coactivator/corepressor	Q9Y618	9612	NCOR2	12q24	human	S2418	PHOSPHORYLATION	454664	AKVSGRPsSRKAKSP		protein degradation; intracellular localization	transcription, induced			4318	1	0	0		
DAP	Autophagy	P51397	1611	DAP	5p15.2	human	S3	PHOSPHORYLATION	14572132	_____MSsPPEGKLE		activity, inhibited	autophagy, altered			14551420	1	1	0	dephosphorylated form of DAP acts as an active suppressor of autophagy 	
YAP1 iso2	Transcription, coactivator/corepressor	P46937-2	10413	YAP1	11q13	human	S384	PHOSPHORYLATION	9764918	SRDESTDsGLSMSSY		ubiquitination	carcinogenesis, inhibited	BTRC(INDUCES)		13320408	1	3	0		
NPM1	RNA binding protein; Translation	P06748	4869	NPM1	5q35.1	human	K215	ACETYLATION	8537512	NQNGKDSkPSSTPRS	Nop14; TFIIF_alpha	molecular association, regulation; intracellular localization	transcription, altered	H3(INDUCES)		8156707	1	1	0	K212/215/229/230/257/267/292R  mutant	
XRCC1	DNA repair	P18887	7515	XRCC1	19q13.2	human	T519	PHOSPHORYLATION	451450	EDPYAGStDENTDSE		molecular association, regulation; intracellular localization		APTX(INDUCES); Pnk1(INDUCES)		3651; 8895	2	3	5		
RAG2	Enzyme, misc.	P21784	19374	Rag2		mouse	T490	PHOSPHORYLATION	455560	QIARALQtPKRNPPL	RAG2_PHD	protein degradation; intracellular localization				5447	3	0	0		
TUBG1	Cytoskeletal protein; Motility/polarity/chemotaxis	P23258	7283	TUBG1	17q21	human	S131	PHOSPHORYLATION	10045600	READGSDsLEGFVLC	Tubulin	intracellular localization	cell cycle regulation			9980424	1	1	0	regulates centrosome biogenesis and homeostasis	
APC1	Cell cycle regulation; Ubiquitin conjugating system	Q9H1A4	64682	ANAPC1	2q12.1	human	S355	PHOSPHORYLATION	455825	AALSRAHsPALGVHS		activity, induced				6328	1	16	2		
hnRNP K iso2	RNA binding protein; RNA splicing; Spliceosome	P61978-2	3190	HNRNPK	9q21.32-q21.33	human	S116	PHOSPHORYLATION	452369	EEGLQLPsPTATSQL		intracellular localization				17482905	2	19	14		
ADRB2	GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR	P07550	154	ADRB2	5q31-q32	human	S356	PHOSPHORYLATION	458917	AYGNGYSsNGNTGEQ		protein degradation; molecular association, regulation; receptor desensitization, altered; receptor internalization, altered		ARRB2(INDUCES)		9394; 8115; 5354441; 7454; 14551416; 14148600	15	0	0		
MAD2L1	Cell cycle regulation	Q13257	4085	MAD2L1	4q27	human	S185	PHOSPHORYLATION	4326275	SEEVRLRsFTTTIHK	HORMA; ATG13	protein conformation				17431518	2	1	1	phosphomimicking 3D mutant (S170, S185, S195) prevented Mad2 conformational transition in vitro	
Akt2	EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor)	P31751	208	AKT2	19q13.1-q13.2	human	S474	PHOSPHORYLATION	448520	RTHFPQFsYSASIRE	Pkinase_C	intracellular localization; enzymatic activity, induced				2626; 1738	16	4	43		
KNG1	Cell adhesion; Contractile protein; Inhibitor protein; Motility/polarity/chemotaxis; Secreted; Secreted, signal peptide	P01042	3827	KNG1	3q27	human	S391	PHOSPHORYLATION	5024713	GFSPFRSsRIGEIKE		protein processing				5014007	1	0	0	inhibits cleavage by kallikrein in vitro	
Tip60	ACETYLTRANSFERASE; Acetyltransferase; EC 2.3.1.-; EC 2.3.1.48; Nuclear receptor co-regulator	Q92993	10524	KAT5	11q13	human	S90	PHOSPHORYLATION	448827	LPGSRPGsPEREVPA		protein stabilization; phosphorylation	transcription, altered			7029; 21655807	3	15	14	APP-dependent transactivation and stabilization.; primes S86 phosphorylation	
MAP2	Cytoskeletal protein; Motility/polarity/chemotaxis	P11137	4133	MAP2	2q34-q35	human	S1782	PHOSPHORYLATION	456422	GAEIITQsPGRSSVA		molecular association, regulation; intracellular localization	cytoskeletal reorganization	TUBA1A(INDUCES); ACTB(INDUCES)		7324105	1	33	15		
Cdc25A	EC 3.1.3.48; Motility/polarity/chemotaxis; PHOSPHATASE; Protein phosphatase, dual-specificity	P30304	993	CDC25A	3p21	human	S519	PHOSPHORYLATION	26342101	KSKREMYsRLKKL__		protein degradation	cell cycle regulation			25789406	1	1	0	proteasome mediated degradation	
P130Cas iso2	Adaptor/scaffold; Motility/polarity/chemotaxis	Q63767-2	25414	Bcar1		rat	Y253	PHOSPHORYLATION	448721	APGSQDIyDVPPVRG			cell motility, altered			2671	8	28	706		
LKB1	Autophagy; EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, CAMK; Protein kinase, Ser/Thr (non-receptor)	Q15831	6794	STK11	19p13.3	human	T336	PHOSPHORYLATION	448150	KDRWRSMtVVPYLED		enzymatic activity, induced				10296905	2	0	0	STRAD increases LKB1 activation 	
SPRY2	Adaptor/scaffold; Inhibitor protein; Motility/polarity/chemotaxis	O43597	10253	SPRY2	13q31.1	human	S112	PHOSPHORYLATION	465675	APLSRSIsTVSSGSR		molecular association, regulation; protein stabilization; ubiquitination		BRAF(DISRUPTS); NEDD4 iso4(INDUCES)		11189922; 9983601; 8112	4	1	0	phosphorylation of this site stabilizes protein by interfering with Y55 phosphorylation, Cbl binding and polyubiquitination ; B-Raf V600E oncogenic mutant does not associate with Spry2 (altered kinase domain conformation); interaction with NEDD4 increases the ubiquitination of Spry2	
EpoR	EC 2.7.10.2; Membrane protein, integral; Receptor, cytokine	P19235	2057	EPOR	19p13.3-p13.2	human	Y504	PHOSPHORYLATION	449885	AEPLPPSyVACS___			apoptosis, inhibited			8833	8	0	0		
PRAS40	Apoptosis	Q96B36	84335	AKT1S1	19q13.33	human	S221	PHOSPHORYLATION	2506802	DLDRIAAsMRALVLR		molecular association, regulation; activity, inhibited		14-3-3 beta(INDUCES)		2425213	1	0	3		
ATR	EC 2.7.11.1; KINASE; Kinase, lipid; Kinase, protein; Membrane protein, integral; Protein kinase, ATYPICAL; Protein kinase, Ser/Thr (non-receptor)	Q13535	545	ATR	3q23	human	T1989	PHOSPHORYLATION	2226546	LCFPENEtPPEGKNM	FAT	molecular association, regulation; enzymatic activity, induced		TOPBP1(INDUCES)		20541900	3	5	25		
DYNLRB1	Motility/polarity/chemotaxis	Q9NP97	83658	DYNLRB1	20q11.21	human	S73	PHOSPHORYLATION	27523608	LTFLRIRsKKNEIMV	Robl_LC7	molecular association, regulation	transcription, induced	DNCLI1(INDUCES)		27519646	1	0	0		
NFM	Cytoskeletal protein	P08553	18040	Nefm		mouse	S669	PHOSPHORYLATION	448045	ADKKKAEsPVKEKAV			cytoskeletal reorganization			7072905	4	13	0	slightly altered axoplasmic organization in 7S/A mice mutant	
HCN4	Channel, cation; Membrane protein, integral; Membrane protein, multi-pass	O70507	330953	Hcn4		mouse	Y554	PHOSPHORYLATION	1240810	TRQRIHDyYEHRYQG		activity, induced				6994	2	0	0	Y476F mutation in Hcn2 and Y554F mutation in Hcn4, abolishes the effect of PP2 on activation.	
cofilin 1	Cytoskeletal protein; Motility/polarity/chemotaxis	P23528	1072	CFL1	11q13	human	Y68	PHOSPHORYLATION	449642	GQTVDDPyATFVKML	Cofilin_ADF	protein degradation; ubiquitination	cell motility, altered; cytoskeletal reorganization			11189929	1	11	420	inhibits cofilin activity to reduce F-actin contents	
APC	Motility/polarity/chemotaxis; Tumor suppressor	P25054	324	APC	5q21-q22	human	S1360	PHOSPHORYLATION	3188801	EFSSGAKsPSKSGAQ			cell cycle regulation			9980419	1	6	0	important for mitotic spindle anchoring to the cell cortex and orientation	
Siglec-10	Cell adhesion; Membrane protein, integral	Q96LC7	89790	SIGLEC10	19q13.3	human	Y667	PHOSPHORYLATION	450087	ESQEELHyATLNFPG		molecular association, regulation		SHP-2(INDUCES); SHP-1(INDUCES)		8807; 2676	2	0	1		
H3	DNA binding protein	P68431	8350	HIST1H3A	6p22.1	human	K15	ACETYLATION	458954	ARKSTGGkAPRKQLA		activity, induced	transcription, induced			3256108; 1173024	111	8	339	only when H3 S10 phosphorylation was followed by acetylation of the residue K14	
Rb	Nuclear receptor co-regulator; Transcription, coactivator/corepressor; Tumor suppressor	P13405	19645	Rb1		mouse	S243	PHOSPHORYLATION	447975	AAIPINGsPRTPRRG		molecular association, regulation		E2F1(DISRUPTS)		1258	12	20	69		
Rb-like 2	Transcription, coactivator/corepressor	Q08999	5934	RBL2	16q12.2	human	S1044	PHOSPHORYLATION	449739	YPFVRTGsPRRIQLS		molecular association, regulation	cell cycle regulation	E2F4(DISRUPTS)		1200; 5981	2	1	4		
Fos	DNA binding protein; Motility/polarity/chemotaxis; Transcription factor	P01100	2353	FOS	14q24.3	human	Y10	PHOSPHORYLATION	473043	FSGFNADyEASSSRC		intracellular localization				9161	2	0	0	critical for association of Fos with endoplasmic reticulum membranes and phospholipid synthesis activation	
HPK1	EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, STE; Protein kinase, Ser/Thr (non-receptor)	P70218	26411	Map4k1		mouse	S171	PHOSPHORYLATION	455474	ATLARRLsFIGTPYW	Pkinase	enzymatic activity, induced				3361003	3	1	7		
4E-T	Karyopherin; Nuclear import; Translation	Q9NRA8	56478	EIF4ENIF1	22q11.2	human	S374	PHOSPHORYLATION	7322864	GLEQAILsPGQNSGN	EIF4E-T	molecular association, regulation		4E-T(INDUCES)		26341738	1	3	24	required for processing bodies (PBs or P bodies) assembly	
STXBP1	Vesicle protein	P61764	6812	STXBP1	9q34.1	human	T574	PHOSPHORYLATION	454395	IGSTHILtPQKLLDT	Sec1	activity, inhibited				4253	2	0	0	exocytosis	
CACNA1B	Channel, calcium; Membrane protein, integral; Membrane protein, multi-pass	Q02294	257648	Cacna1b		rat	S425	PHOSPHORYLATION	465547	KRAATKKsRNDLIHA		activity, inhibited				6337819; 7994	2	1	0		
NFAT1	DNA binding protein; Transcription factor	Q60591	18019	Nfatc2		mouse	S179	PHOSPHORYLATION	447844	ASSGSSAsFISDTFS			transcription, inhibited			1188	0	1	0		
SIRT1	Apoptosis; DEACETYLASE; Deacetylase; EC 3.5.1.-; Nuclear receptor co-regulator	Q96EB6	23411	SIRT1	10q21.3	human	T530	PHOSPHORYLATION	6006905	YLSELPPtPLHVSED		acetylation; intracellular localization; enzymatic activity, induced	cell cycle regulation			5930046; 12021300	4	3	19		
STEP	EC 3.1.3.48; Membrane protein, multi-pass; Motility/polarity/chemotaxis; PHOSPHATASE; Protein phosphatase, tyrosine (non-receptor)	P54829	84867	PTPN5	11p15.1	human	S245	PHOSPHORYLATION	448294	GLQERRGsNVSLTLD		enzymatic activity, inhibited				14654315	5	0	0		
TIF1B	EC 6.3.2.-; KINASE; Kinase, protein; Ligase; Nuclear receptor co-regulator; Protein kinase, ATYPICAL; Protein kinase, atypical; Transcription, coactivator/corepressor; UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase	Q13263	10155	TRIM28	19q13.4	human	S473	PHOSPHORYLATION	452391	SGVKRSRsGEGEVSG			cell cycle regulation; DNA repair, induced			25227625; 27959900	8	62	20	involved in DNA damage response	
neurogenin 2	Transcription factor	P70447	11924	Neurog2		mouse	Y241	PHOSPHORYLATION	457462	SPGSDVDyWQPPPPE			cell motility, altered			7009	1	0	0	Phosphorylation required for cortical neuron migration and cell body translocation.  Phenotypes partially rescued by expression of dominant negative RhoA.	
DRD1	GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR	P18901	24316	Drd1		rat	S256	PHOSPHORYLATION	455301	NPVECAQsESSFKMS	7tm_1	receptor desensitization, altered				4475	1	0	0		
zyxin	Cell adhesion; Motility/polarity/chemotaxis	Q15942	7791	ZYX	7q32	human	S142	PHOSPHORYLATION	460644	PQPREKVsSIDLEID		molecular association, regulation; intracellular localization		acinus(INDUCES); 14-3-3 gamma(INDUCES)		11992	2	8	0	phosphorylation does not protect zyxin from proteolytic cleavage by caspase, but inhibits acinus degradation and suppresses apoptosis 	
PLK4	EC 2.7.11.21; KINASE; Kinase, protein; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor)	Q64702	20873	Plk4		mouse	S298	PHOSPHORYLATION	12654004	STTITASsGTSLSGS		protein degradation; ubiquitination				12525201	1	1	0		
SNAP23	Vesicle protein	O09044	20619	Snap23		mouse	S120	PHOSPHORYLATION	455263	NVVSKQPsRITNGQP	SNAP-25; Use1; Fib_alpha		exocytosis, altered			4049520	3	2	0	required for IKK2-mediated mast cells degranulation	
IGF1R	EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Protein kinase, TK; Protein kinase, tyrosine (receptor)	P08069	3480	IGF1R	15q26.3	human	S1313	PHOSPHORYLATION	2091904	DPSASSSsLPLPDRH		activity, induced; phosphorylation	apoptosis, altered; cell differentiation, altered; cell growth, altered			2703; 2727	2	0	0	observed in Y980F +  S1310-1313A; ERK phosphorylation	
PTEN	Carbohydrate Metabolism - inositol phosphate; EC 3.1.3.16; EC 3.1.3.48; EC 3.1.3.67; Motility/polarity/chemotaxis; Nuclear receptor co-regulator; PHOSPHATASE; Phosphatase, lipid; Tumor suppressor	O08586	19211	Pten		mouse	S370	PHOSPHORYLATION	448649	TSVTPDVsDNEPDHY		protein stabilization				15755106	9	4	0		
RUFY1	Ubiquitin conjugating system	Q96T51	80230	RUFY1	5q35.3	human	Y389	PHOSPHORYLATION	451277	TKVELETyKQTRQGL	DUF972	intracellular localization				3500	1	0	2		
KCNJ6	Membrane protein, integral; Membrane protein, multi-pass	P48550		Kcnj6		rat	S9	PHOSPHORYLATION	4707737	TMAKLTEsMTNVLEG		protein processing				6313500	2	2	0	regulates channel recycling to the membrane 	
MSK2	EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor)	O75676	8986	RPS6KA4	11q11-q13	human	S196	PHOSPHORYLATION	450046	EEKERTFsFCGTIEY	Pkinase	enzymatic activity, induced				11463; 1264	4	0	1		
G6PD iso3	Carbohydrate Metabolism - pentose phosphate pathway; Cell development/differentiation; EC 1.1.1.49; Other Amino Acids Metabolism - glutathione; Oxidoreductase	P11413-3	2539	G6PD	Xq28	human	S210	PHOSPHORYLATION	15207801	FGRDLQSsDRLSNHI	G6PD_N	enzymatic activity, induced				15026115	1	0	0		
RARA	DNA binding protein; Nuclear receptor; Transcription factor	P10276	5914	RARA	17q21	human	T181	PHOSPHORYLATION	455328	CSESYTLtPEVGELI		protein degradation; ubiquitination				4599	2	0	0		
MEKK3	EC 2.7.11.25; KINASE; Kinase, protein; Protein kinase, STE; Protein kinase, Ser/Thr (non-receptor)	Q61084	26406	Map3k3		mouse	S526	PHOSPHORYLATION	458796	MSGTGIRsVTGTPYW	Pkinase	enzymatic activity, induced		14-3-3 epsilon(INDUCES)		7435	4	1	0	interaction with 14-3-3 epsilon prevents dephosphorylation of  S526.  critical site for activation of ERK, p38 and JNK kinases.	
HER2	EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Protein kinase, TK; Protein kinase, tyrosine (receptor)	P04626	2064	ERBB2	17q12	human	Y1221	PHOSPHORYLATION	449744	SPAFDNLyYWDQDPP		enzymatic activity, induced	cell motility, altered; cell growth, altered			10001310; 4215300; 14821615	19	1	10		
JAK2	EC 2.7.10.2; KINASE; Kinase, protein; Protein kinase, TK; Protein kinase, tyrosine (non-receptor)	Q62120	16452	Jak2		mouse	Y201	PHOSPHORYLATION	470070	DQTPLAVyNSVSYKT		molecular association, regulation		SHP-2(INDUCES)		8958	3	1	0	Jak2 phosphorylation mediates binding to SHP-2, which is in a complex with AT-1	
KLF5	C2H2-type zinc finger protein; DNA binding protein; Transcription factor	Q13887	688	KLF5	13q22.1	human	S153	PHOSPHORYLATION	10945600	LRTGLYKsQRPCVTH			transcription, altered			10296917	1	0	0	S153A mutant moderately reduces transactivation. 	
5-LO	EC 1.13.11.34; Lipid Metabolism - arachidonic acid; Lipid Metabolism - linoleic acid; Nuclear envelope; Oxidoreductase	P09917	240	ALOX5	10q11.2	human	S524	PHOSPHORYLATION	452140	GMRGRKSsGFPKSVK	Lipoxygenase; DUF1250	intracellular localization; enzymatic activity, inhibited				6964; 4067	3	0	0	phosphorylation inhibits nuclear import of 5-LO, resulting in its accumulation in the cytoplasm.	
HNF4 alpha	DNA binding protein; Nuclear receptor; Transcription factor	P22449	25735	Hnf4a		rat	S142	PHOSPHORYLATION	458368	DRISTRRsSYEDSSL	Foamy_virus_ENV	molecular association, regulation	transcription, altered		DNA(DISRUPTS)	12482214	3	1	6		
REL	Transcription factor	Q04864	5966	REL	2p13-p12	human	S492	PHOSPHORYLATION	456135	ISDPNMLsNCSVNMM		activity, induced	transcription, induced			1975603	2	0	0	both site-directed S460A or previously characterized spontaneous S460N are not responsive to NIK-induced activation of transcription at the IL-2 promoter.  S460N is also much less responsive to CD3- or CD3+CD28-induced transcriptional upregulation at the IL-2 promoter. 	
NEDD4L	EC 6.3.2.-; EC 6.3.2.19; Ligase; UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase	Q96PU5	23327	NEDD4L	18q21	human	S428	PHOSPHORYLATION	487434	AEDGASGsATNSNNH		activity, inhibited				12284	1	0	0	Phosphorylation of S342 and S428 (more important site) inhibits Nedd4L which regulates ENaC activity.	
NKEF-A	EC 1.11.1.15; Oxidoreductase	Q06830	5052	PRDX1	1p34.1	human	S32	PHOSPHORYLATION	15334103	QFKDISLsDYKGKYV	AhpC-TSA	protein conformation; enzymatic activity, induced	apoptosis, altered			15235210	1	5	0		
Akt1	EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor)	P31750	11651	Akt1		mouse	S473	PHOSPHORYLATION	447855	RPHFPQFsYSASGTA	Pkinase_C	protein degradation; molecular association, regulation; ubiquitination; intracellular localization; enzymatic activity, induced	cell cycle regulation; apoptosis, altered; apoptosis, inhibited; cytoskeletal reorganization; transcription, induced; cell growth, altered	HSP90A(NOT_REPORTED); CHIP(INDUCES)		4534; 7550843; 7235; 4646610; 7397604; 6842200; 22433506; 5663; 7550836; 5430; 1173002; 4261000; 4646613; 15031302; 5300; 5766; 1610	1158	5	43	-/- MEM55B KO MEFs increased proliferation and tumor growth  in KO mice.; regulates radiation survival; sensitizes cells to Ros-mediated apoptosis	
p53	Activator protein; DNA binding protein; Motility/polarity/chemotaxis; Nuclear receptor co-regulator; Transcription factor; Tumor suppressor	P04637	7157	TP53	17p13.1	human	T155	PHOSPHORYLATION	455908	DSTPPPGtRVRAMAI	P53	protein degradation		MDM2(INDUCES)		8706; 8918; 6398	4	0	1	reduced by O-GlcNAc glycosylation of p53 S149	
MafA	DNA binding protein; Transcription factor	Q8CF90	378435	Mafa		mouse	S14	PHOSPHORYLATION	1713900	MGAELPSsPLAIEYV		molecular association, regulation		MafA(INDUCES)	DNA(NOT_REPORTED)	13326312	2	2	0		
PRMT3	C2H2-type zinc finger protein; EC 2.1.1.-; METHYLTRANSFERASE; Methyltransferase; Methyltransferase, protein arginine	O60678	10196	PRMT3	11p15.1	human	Y87	PHOSPHORYLATION	17489700	HKHGLEFyGYIKLIN	zf-C2H2_2	molecular association, regulation; enzymatic activity, inhibited		RPS2(INDUCES)		17482908	1	0	0		
ChAT iso3	ACETYLTRANSFERASE; Acetyltransferase; EC 2.3.1.6; Lipid Metabolism - glycerophospholipid	P28329-3	1103	CHAT	10q11.2	human	S346	PHOSPHORYLATION	454035	LLKHVTQsSRKLIRA	Carn_acyltransf	enzymatic activity, induced				4182	1	0	0		
HER4	EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Protein kinase, TK; Protein kinase, tyrosine (receptor)	Q15303	2066	ERBB4	2q33.3-q34	human	Y1258	PHOSPHORYLATION	451685	STLQHPDyLQEYSTK		molecular association, regulation		Shc1(INDUCES)		4651319	0	1	2		
CLK2	EC 2.7.12.1; KINASE; Kinase, protein; Protein kinase, CMGC; Protein kinase, dual-specificity	P49760	1196	CLK2	1q21	human	T127	PHOSPHORYLATION	15339202	RRRRRSRtFSRSSSQ			apoptosis, altered; cell growth, altered			15235213	1	0	0		
MDC1	Cell cycle regulation	Q14676	9656	MDC1	6p21.3	human	S376	PHOSPHORYLATION	477758	LQESQAGsDTDVEEG		molecular association, regulation	cell cycle regulation	NBS1(INDUCES)		4042508	1	11	26	MDC1-NBS1 interaction regulates intra-S-phase checkpoint activation	
Kv2.1	Channel, cation; Channel, ligand-gated; Channel, potassium; Membrane protein, integral; Membrane protein, multi-pass	P15387	25736	Kcnb1		rat	Y690	PHOSPHORYLATION	22874701	LLPSLGLyHDPLRNR	Kv2channel	intracellular localization				22736104	1	1	2	regulates intracellular trafficking of Kv2.1	
CFTR	Channel, chloride; EC 3.6.3.49; Hydrolase; Membrane protein, integral; Membrane protein, multi-pass; Transporter	P13569	1080	CFTR	7q31.2	human	S795	PHOSPHORYLATION	449982	TASTRKVsLAPQANL	CFTR_R	activity, induced; molecular association, regulation; enzymatic activity, inhibited; protein conformation		CFTR(INDUCES)		4474; 2537	5	4	0		
ATF-4	DNA binding protein; Transcription factor	P18848	468	ATF4	22q13.1	human	S245	PHOSPHORYLATION	451446	TRGSPNRsLPSPGVL		activity, induced	carcinogenesis, induced; cell growth, altered			3649; 22495303	3	0	0		
APC	Motility/polarity/chemotaxis; Tumor suppressor	P25054	324	APC	5q21-q22	human	S2054	PHOSPHORYLATION	454101	MPKKKKPsRLKGDNE		intracellular localization				4209; 4210	2	0	0	regulates nuclear import and localization	
ATP2B2	Cell development/differentiation; EC 3.6.3.8; Endoplasmic reticulum; Hydrolase; Membrane protein, integral; Membrane protein, multi-pass; Transporter	Q01814	491	ATP2B2	3p25.3	human	T1139	PHOSPHORYLATION	11422300	RGLNRIQtQIRVVKA	ATP_Ca_trans_C	enzymatic activity, induced				10212803	1	0	0	effect (activation vs. inhibition) depends on PKC isozyme and lipid associated with ATP2B2	
SIAH2	EC 6.3.2.-; EC 6.3.2.19; Ligase; Transcription, coactivator/corepressor; UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase	O43255	6478	SIAH2	3q25	human	S16	PHOSPHORYLATION	26371003	PSANKPCsKQPPPQP		protein degradation; intracellular localization; enzymatic activity, induced	cytoskeletal reorganization			26341714	2	1	0		
Pyk2	EC 2.7.10.2; KINASE; Kinase, protein; Nuclear receptor co-regulator; Protein kinase, TK; Protein kinase, tyrosine (non-receptor)	Q14289	2185	PTK2B	8p21.1	human	Y402	PHOSPHORYLATION	447955	CSIESDIyAEIPDET		molecular association, regulation; intracellular localization; phosphorylation; enzymatic activity, induced	cell cycle regulation; cell motility, altered	RASA1(INDUCES); Src(INDUCES); HER2(INDUCES)		3614; 3562; 8763; 8085; 11999213; 5121519; 6904	61	2	21		
AID	EC 3.5.4.5; Hydrolase	Q9WVE0	11628	Aicda		mouse	S38	PHOSPHORYLATION	457604	YVVKRRDsATSCSLD	APOBEC_N	molecular association, regulation; enzymatic activity, induced	chromatin organization, altered	RPA1(INDUCES)	DNA(INDUCES)	970024; 2365402; 6421500; 7195	10	3	0	Mutation of either site significantly decreases  gene conversion (GCV) & somatic hypermutation (SHM) frequency.	
TRPC3	Channel, cation; Membrane protein, integral; Membrane protein, multi-pass	Q13507	7222	TRPC3		human	S251	PHOSPHORYLATION	458336	KNDYRKLsMQCKDFV		activity, inhibited				7387; 8870	2	0	0	inhibits store-operated calcium influx	
STYK1	EC 2.7.10.2; KINASE; Kinase, protein; Membrane protein, integral; Protein kinase, TK; Protein kinase, tyrosine (receptor)	Q6J9G1	243659	Styk1		mouse	Y363	PHOSPHORYLATION	458345	SSCSHAMyNIMKCCW	Pkinase_Tyr		apoptosis, inhibited; cell growth, altered			7403	1	0	0	mutation of this site promotes cellular apoptosis	
AQP2	Channel, misc.; Membrane protein, integral; Membrane protein, multi-pass	P34080	25386	Aqp2		rat	S264	PHOSPHORYLATION	2238600	VELHSPQsLPRGSKA		intracellular localization				2195463	9	6	0		
CREM iso3	DNA binding protein; Transcription factor	P27699	12916	Crem		mouse	S156	PHOSPHORYLATION	450064	PKIEEEKsEEEGTPP		activity, inhibited	transcription, altered			2633	2	0	0		
KIR2DL1	Membrane protein, integral; Receptor, misc.	P43626	3802	KIR2DL1	19q13.4	human	Y302	PHOSPHORYLATION	462345	QDPQEVTyTQLNHCV		molecular association, regulation	signaling pathway regulation	supervillin(INDUCES)		18410808	1	2	1	supervillin is required for KIR2DL1-mediated inhibition of Vav1 and Erk phosphorylation	
ER-beta	DNA binding protein; Nuclear receptor	Q92731	2100	ESR2	14q23.2	human	S105	PHOSPHORYLATION	447914	LYAEPQKsPWCEARS	ERbeta_N; Oest_recep	activity, induced; intracellular localization				7179; 15754002	4	0	0	expressed in nucleus and as nuclear speckles	
SNIP iso5	Cytoskeletal protein	Q9C0H9-5	80725	SRCIN1	17q12	human	Y264	PHOSPHORYLATION	456703	IYRKEPLyAAFPGSH		molecular association, regulation		CSK(INDUCES)		27571206	1	3	91		
GSK3B	EC 2.7.11.1; EC 2.7.11.26; KINASE; Kinase, protein; Protein kinase, CMGC; Protein kinase, Ser/Thr (non-receptor)	P18266	84027	Gsk3b		rat	Y216	PHOSPHORYLATION	448569	RGEPNVSyICSRYYR	Pkinase	enzymatic activity, induced	apoptosis, induced			1111; 1110	59	70	4190		
PKN2	EC 2.7.11.13; KINASE; Kinase, protein; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor)	Q16513	5586	PKN2	1p22.2	human	S815	PHOSPHORYLATION	4754738	MGYGDRTsTFCGTPE	Pkinase	enzymatic activity, induced				10353916	1	4	37		
BARD1	EC 6.3.2.-; EC 6.3.2.19; Ligase; Tumor suppressor; UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase	Q99728	580	BARD1	2q34-q35	human	T714	PHOSPHORYLATION	465470	PKPDSDVtQTINTVA	BRCT		RNA stability, altered			7995	1	0	1	inhibits mRNA processing 	
DNER	Membrane protein, integral; Receptor, misc.	Q8NFT8	92737	DNER	2q36.3	human	Y681	PHOSPHORYLATION	473322	RPAYEEFyNCRSIDS		intracellular localization				2831768	1	0	2		
E2F1	DNA binding protein; Transcription factor	Q01094	1869	E2F1	20q11.2	human	S337	PHOSPHORYLATION	447869	IVSPPPSsPPSSLTT		molecular association, regulation	cell cycle regulation	Rb(DISRUPTS); E4(INDUCES)		1337	2	0	0		
VAMP4	Membrane protein, integral; Vesicle protein	O70480	53330	Vamp4		mouse	S30	PHOSPHORYLATION	454285	RNLLEDDsDEEEDFF		molecular association, regulation; intracellular localization		PACS-1(INDUCES)		5714	1	39	9		
PAK3	EC 2.7.1.; EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, STE; Protein kinase, Ser/Thr (non-receptor)	Q62829	29433	Pak3		rat	S139	PHOSPHORYLATION	448123	VNNQKYMsFTSGDKS		enzymatic activity, induced				738	3	3	0		
Bcl-2	Apoptosis; Autophagy; Membrane protein, integral	P10415	596	BCL2	18q21.3	human	T56	PHOSPHORYLATION	448655	FSSQPGHtPHPAASR		protein stabilization; molecular association, regulation; ubiquitination	cell cycle regulation; apoptosis, altered; apoptosis, induced; apoptosis, inhibited	PPP1CA(INDUCES); CDK1(INDUCES); NCL(INDUCES)		6431; 4647111; 4647112; 6115915; 7181; 1830; 2365401; 7613744; 4647110	11	0	0	phosphorylation induced by viral infection	
rhodopsin	GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR	P02699	509933	RHO		cow	S338	PHOSPHORYLATION	448679	DEASTTVsKTETSQV		molecular association, regulation; protein conformation		SAG(INDUCES)		3621	6	5	0	Computational and in vitro data. S343 may be a weaker interaction.	
PDE3A	EC 3.1.4.17; Membrane protein, integral; Membrane protein, multi-pass; Nucleotide Metabolism - purine; Phosphodiesterase	Q9Z0X4	54611	Pde3a		mouse	S292	PHOSPHORYLATION	471417	KRRRRSSsVVAGEMS		enzymatic activity, induced				9112	1	0	10	required for insulin-dependent Xenopus oocyte maturation; 
activated during oocytes maturation in mouse treated with hCG 	
LEDGF	Motility/polarity/chemotaxis; Transcription, coactivator/corepressor	Q9UER6	11168	PSIP1	9p22.3	human	S206	PHOSPHORYLATION	7231784	MVKQPCPsESDIITE		phosphorylation				11189921	1	6	0	stimulates phosphorylation of MCM2 at S53	
ENaC-gamma	Channel, sodium; Membrane protein, integral; Membrane protein, multi-pass	P37091	24768	Scnn1g		rat	T599	PHOSPHORYLATION	2228601	QDNPALDtDDDLPTF		activity, induced; intracellular localization				2195469	1	0	0	 membrane expression of ENAC beta and gamma, and may translocate CK2 to the cell membrane.; channel activation	
PIKFYVE	Carbohydrate Metabolism - inositol phosphate; EC 2.7.1.150; EC 2.7.1.68; Kinase, lipid; Motility/polarity/chemotaxis	Q9Y2I7	200576	PIKFYVE	2q34	human	S318	PHOSPHORYLATION	3216759	LSLDRSGsPMVPSYE		enzymatic activity, induced				7483301	3	1	7	induce activation of chloride channel CLCN2	
AR	DNA binding protein; Nuclear receptor; Transcription factor	P10275	367	AR	Xq12	human	T280	PHOSPHORYLATION	15605002	VPPAVRPtPCAPLAE	Androgen_recep	activity, induced; molecular association, regulation	transcription, altered; cell growth, altered		DNA(NOT_REPORTED)	15562508	1	0	0		
Smad2	DNA binding protein; Transcription factor	Q15796	4087	SMAD2	18q21.1	human	S464	PHOSPHORYLATION	447567	GSPSVRCsSMS____		activity, induced; intracellular localization	transcription, induced; transcription, altered	Smad4(INDUCES)		2448; 5309416	5	0	1	nuclear localization	
VDAC1	Channel, misc.; Membrane protein, integral; Mitochondrial	P21796	7416	VDAC1	5q31	human	S104	PHOSPHORYLATION	452268	LTFDSSFsPNTGKKN	Porin_3; TM	protein stabilization	apoptosis, induced			2704314	1	44	0		
FLT3	EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Protein kinase, TK; Protein kinase, tyrosine (receptor)	Q00342	14255	Flt3		mouse	Y892	PHOSPHORYLATION	456469	FSLGVNPyPGIPVDA	Pkinase_Tyr	protein stabilization; enzymatic activity, induced				6717	1	0	0		
SUGT1	Cell cycle regulation; Ubiquitin conjugating system	Q9Y2Z0	10910	SUGT1	13q14.3	human	S331	PHOSPHORYLATION	18016406	VKRAMNKsFMESGGT	SGS	intracellular localization	cell cycle regulation; cytoskeletal reorganization	DSN1(INDUCES)		25712649	2	1	2	 localization at kinetetchore; mitotic progression;  association with MIS12 complex;  kinetochore-microtubule attachments	
SPAG5	Cell cycle regulation	Q7TME2	54141	Spag5		mouse	S66	PHOSPHORYLATION	460412	KERCNNSsPVDFINT			cell cycle regulation			11270013	1	4	1	T24/66/447A mutant impairs meiosis progression	
HER2	EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Protein kinase, TK; Protein kinase, tyrosine (receptor)	P04626	2064	ERBB2	17q12	human	Y1139	PHOSPHORYLATION	448678	TCSPQPEyVNQPDVR		molecular association, regulation	cell motility, altered; cell adhesion, altered; transcription, induced; signaling pathway regulation; cell growth, altered	Src(INDUCES); GRB7(INDUCES); JAK2(NOT_REPORTED); Grb2(INDUCES)		2852654; 4215300; 3532; 8547; 10144208	9	2	43		
FLRT1	Cell adhesion; Membrane protein, integral; Motility/polarity/chemotaxis	Q9NZU1	23769	FLRT1	11q12-q13	human	Y605	PHOSPHORYLATION	14150100	PYRAKEEyVVHTIFP		intracellular localization	cell growth, altered			14058618	1	0	0	regulates ERK1/2 activation	
Chk2	EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, CAMK; Protein kinase, Ser/Thr (non-receptor)	O96017	11200	CHEK2	22q12.1	human	T26	PHOSPHORYLATION	447547	SQPHGSVtQSQGSSS	DUF966	phosphorylation; enzymatic activity, induced				1026	3	1	0		
EGFR	EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Protein kinase, TK; Protein kinase, tyrosine (receptor)	P00533	1956	EGFR	7p12	human	S695	PHOSPHORYLATION	451484	LVEPLTPsGEAPNQA		receptor internalization, altered				3851; 3881	4	6	1		
smMLCK	EC 2.7.11.18; KINASE; Kinase, protein; Protein kinase, CAMK; Protein kinase, Ser/Thr (non-receptor)	Q15746	4638	MYLK	3q21	human	Y471	PHOSPHORYLATION	451415	YEDAGSHyLCLLKAR	I-set	molecular association, regulation; enzymatic activity, induced		cortactin(INDUCES)		8392; 12482245	2	0	5		
NSF	Adaptor/scaffold; Autophagy; EC 3.6.4.6; Protease; Vesicle protein	P46459	4905	NSF	17q21	human	Y83	PHOSPHORYLATION	453414	QEIEVSLyTFDKAKQ	CDC48_N	molecular association, regulation; enzymatic activity, induced		SNAP-alpha(DISRUPTS)		4132	1	1	0	Y83 phosphorylation increased the intrinsic ATPase activity of NSF.	
neurogenin 1	Cell development/differentiation; DNA binding protein; Transcription factor	P70660	18014	Neurog1		mouse	T130	PHOSPHORYLATION	1186000	FPDDTKLtKIETLRF	HLH	protein stabilization; molecular association, regulation		E2A(NOT_REPORTED)		1172802	1	0	0	frog (Xenopus) E2A	
ADRB2	GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR	P04274	101836719	Adrb2		hamster	S261	PHOSPHORYLATION	447908	SGHGLRRsSKFCLKE	7tm_1	receptor desensitization, altered				1641	5	0	0	S262 was primary site of cAPK desensitization, while either 261 or 262 for PKC desensitization, as well as ADRB2 expression level. 	
ARAF	EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, Ser/Thr (non-receptor); Protein kinase, TKL	P10398	369	ARAF	Xp11.4-p11.2	human	Y301	PHOSPHORYLATION	455521	LGYRDSGyYWEVPPS		activity, induced				5373	1	2	9		
IP3R1	Channel, calcium; Channel, ligand-gated; Membrane protein, integral; Membrane protein, multi-pass; Receptor, misc.	P11881	16438	Itpr1		mouse	S1755	PHOSPHORYLATION	450682	RPSGRREsLTSFGNG		activity, induced				9274	9	12	10	Ca(2+) mobilization	
E2A	DNA binding protein; Transcription factor	P15923	6929	TCF3	19p13.3	human	S341	PHOSPHORYLATION	10359100	KALASIYsPDHSSNN		activity, inhibited	transcription, inhibited			10353939	1	0	3		
SH3RF1	Adaptor/scaffold; EC 6.3.2.-; EC 6.3.2.19; Ligase; UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase	Q7Z6J0	57630	SH3RF1	4q32.3	human	S304	PHOSPHORYLATION	482847	KNTKKRHsFTSLTMA		molecular association, regulation	apoptosis, inhibited	RAC1(INDUCES)		11801	1	8	22		
FOXO6	DNA binding protein	Q70KY4	329934	Foxo6		mouse	T26	PHOSPHORYLATION	2899101	QSRPRSCtWPLPQPD		intracellular localization	transcription, inhibited			8511; 12482251	2	0	0	nuclear export; Mediates growth factor sensitivity and inhibition transcriptional activity independent of translocation. 	
ROBO1	Cell adhesion; Membrane protein, integral; Motility/polarity/chemotaxis	Q9Y6N7	6091	ROBO1	3p12	human	Y1073	PHOSPHORYLATION	465118	PSGQPTPyATTQLIQ		activity, inhibited				12660606	1	1	5		
PLCG2	Carbohydrate Metabolism - inositol phosphate; EC 3.1.4.11; Motility/polarity/chemotaxis; Phospholipase	P24135	29337	Plcg2		rat	Y759	PHOSPHORYLATION	447941	LYDVSRMyVDPSEIN		enzymatic activity, induced				2451	9	8	225		
p53	Activator protein; DNA binding protein; Motility/polarity/chemotaxis; Nuclear receptor co-regulator; Transcription factor; Tumor suppressor	P04637	7157	TP53	17p13.1	human	S215	PHOSPHORYLATION	454242	DRNTFRHsVVVPYEP	P53	protein degradation; protein stabilization; ubiquitination; protein conformation; activity, inhibited	cell cycle regulation; carcinogenesis, induced; apoptosis, inhibited; transcription, inhibited; transcription, altered			4243; 25347042; 17613011	4	0	0		
vimentin	Cytoskeletal protein; Motility/polarity/chemotaxis	P08670	7431	VIM	10p13	human	S7	PHOSPHORYLATION	455449	_MSTRSVsSSSYRRM	Filament_head		cell motility, altered			7549203	6	11	1		
TEAD4	DNA binding protein; Transcription factor	Q15561	7004	TEAD4	12p13.3-p13.2	human	S322	PHOSPHORYLATION	451164	GVSSQYEsPENMIIT	TEA	activity, induced				3191	1	0	0	Mutation of S315 to alanine reduced alpha1-adrenergic activation of TEF-3.	
Jun	Transcription factor	P05412	3725	JUN	1p32-p31	human	T89	PHOSPHORYLATION	17737602	QSSNGHItTTPTPTQ	Jun		carcinogenesis, altered; cell growth, altered			17675043	1	0	0		
IRF7	DNA binding protein; Transcription factor	Q92985	3665	IRF7	11p15.5	human	S483	PHOSPHORYLATION	486437	SSLSLCLsSANSLYD			transcription, inhibited			8586	2	0	0		
CRYAB	Chaperone	P02511	1410	CRYAB	11q22.3-q23.1	human	S45	PHOSPHORYLATION	448748	FPTSTSLsPFYLRPP	Crystallin	activity, induced; protein degradation; molecular association, regulation; intracellular localization; protein conformation		CRYAB(DISRUPTS); FBX4(INDUCES)		1172875; 8402; 5906; 1977; 4066; 8239; 6695	24	6	1	increased chaperone-like activity and subunit exchange in vitro	
PFKFB2	Carbohydrate Metabolism - fructose and mannose; EC 2.7.1.105; EC 3.1.3.46; Kinase, other; Motility/polarity/chemotaxis; Phosphatase (non-protein)	P26285	287019	PFKFB2		cow	S467	PHOSPHORYLATION	448460	PVRMRRNsFTPLSSS		molecular association, regulation; enzymatic activity, induced			Other(INDUCES)	3947; 1066009	9	23	319	decreases Km for F6P	
CAMK2B	EC 2.7.1.123; EC 2.7.11.17; KINASE; Kinase, protein; Protein kinase, CAMK; Protein kinase, Ser/Thr (non-receptor)	P28652	12323	Camk2b		mouse	T287	PHOSPHORYLATION	450048	SMMHRQEtVECLKKF		enzymatic activity, induced				6764; 5354414	13	10	106		
tensin 3	Adaptor/scaffold; Motility/polarity/chemotaxis	Q68CZ2	64759	TNS3	7p12.3	human	Y1256	PHOSPHORYLATION	462739	KGCSNEPyFGSLTAL	SH2	molecular association, regulation	cell motility, altered; cell growth, altered	P130Cas(INDUCES); Sam68(INDUCES); FAK(INDUCES)		9775901	1	0	15	contributes to tumorigenesis and metastasis	
HEC1	Cell cycle regulation	O14777	10403	NDC80	18p11.32	human	S69	PHOSPHORYLATION	474513	SGHGSRNsQLGIFSS	Ndc80_HEC		cell cycle regulation			9229	1	5	6	mutation of six N-terminal residues (S5,S15,S44,T49,S55 and S69) to alanines interferes with mitosis	
eEF-2	Translation; Translation elongation	P55823		EEF2		rabbit	T58	PHOSPHORYLATION	450254	GETRFTDtRKDEQER	GTP_EFTU	activity, inhibited				2334	2	12	34		
hnRNP A1	RNA binding protein; RNA splicing; Spliceosome	P04256	29578	Hnrnpa1		rat	S192	PHOSPHORYLATION	456539	EMASASSsQRGRSGS	NID	activity, inhibited				2852618	2	0	1		
AML3	DNA binding protein; Transcription factor	Q13950	860	RUNX2	6p21	human	S28	PHOSPHORYLATION	3053615	PSTSRRFsPPSSSLQ	Suf; TFIIA; Spt20; DUF2828; Med15		transcription, altered			7324302	5	5	1		
occludin	Cell adhesion; Membrane protein, integral; Membrane protein, multi-pass; Motility/polarity/chemotaxis	Q16625	100506658	OCLN	5q13.1	human	T403	PHOSPHORYLATION	471471	DHYETDYtTGGESCD	DUF342; APG6	intracellular localization				5926301	2	3	4		
14-3-3 zeta	Adaptor/scaffold; Motility/polarity/chemotaxis	P63104	7534	YWHAZ	8q23.1	human	S184	PHOSPHORYLATION	449855	FYYEILNsPEKACSL	14-3-3; CIA30; TPR_12	protein stabilization; molecular association, regulation; protein conformation; phosphorylation		HSP20(INDUCES); JNK1(NOT_REPORTED); Bax(DISRUPTS)		7098; 18415100; 4651305; 6648	5	4	0		
IRS1	Adaptor/scaffold; Motility/polarity/chemotaxis	P35570	25467	Irs1		rat	S307	PHOSPHORYLATION	447558	TESITATsPASMVGG		molecular association, regulation; phosphorylation		InsR(DISRUPTS)		2750; 2749	62	5	0		
MDM2	EC 6.3.2.-; EC 6.3.2.19; Inhibitor protein; Ligase; UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase	Q00987	4193	MDM2	12q14.3-q15	human	Y276	PHOSPHORYLATION	465467	SDEDDEVyQVTVYQA		molecular association, regulation; intracellular localization		p14ARF(INDUCES)		7993	1	1	0	contributes to Hdm2-mediated turnover of p53	
GABBR2	GPCR, family 3; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR	O88871	83633	Gabbr2		rat	S783	PHOSPHORYLATION	473060	VTSVNQAsTSRLEGL	DUF869	activity, induced				9147	3	0	0	decreases attenuation of receptor activation;  promotes neuronal survival after ischemia 	
IRS1	Adaptor/scaffold; Motility/polarity/chemotaxis	P35568	3667	IRS1	2q36	human	S629	PHOSPHORYLATION	478346	VPSGRKGsGDYMPMS		molecular association, regulation		PIK3R1(INDUCES)		12074	3	5	36		
FGFBP1		Q9MZ06	281812	FGFBP1		cow	S36	PHOSPHORYLATION	487543	NRRGSKAsADESLAL	FGF-BP1	molecular association, regulation		FGF1(DISRUPTS)		12272	1	0	0		
PKCE	EC 2.7.11.13; KINASE; Kinase, protein; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor)	Q02156	5581	PRKCE	2p21	human	S368	PHOSPHORYLATION	2085101	NNIRKALsFDNRGEE		molecular association, regulation	cell cycle regulation; transcription, altered	14-3-3 beta(INDUCES)		2807209; 3301203	3	6	0		
STAT1	DNA binding protein; Transcription factor	Q9QXK0	25124	Stat1		rat	S727	PHOSPHORYLATION	447753	TENLLPMsPEEFDEM	STAT1_TAZ2bind	activity, induced	apoptosis, induced; apoptosis, inhibited; transcription, altered			4757; 6401	79	9	82		
DSN1	Cell cycle regulation	Q9H410	79980	DSN1	20q11.23	human	S100	PHOSPHORYLATION	480153	RQSWRRAsMKETNRR	Mis12_component	intracellular localization				3301210	3	2	5	 stabilizes microtubule-kinetochore attachment; regulates association of proteins (CENP-E, Nuf2) with the kinetochore	
ATF-2	C2H2-type zinc finger protein; Transcription factor	P15336	1386	ATF2	2q32	human	T52	PHOSPHORYLATION	23305000	HKHKHEMtLKFGPAR		intracellular localization	carcinogenesis, induced; apoptosis, inhibited; transcription, induced			23260321	1	0	1	T52 phosphorylation negatively regulates ATF-2 mitochondrial localization and basal transcriptional activity of ATF-2.	
Kv1.2	Channel, potassium; Membrane protein, integral; Membrane protein, multi-pass	P63142	25468	Kcna2		rat	S440	PHOSPHORYLATION	1818100	TSCPKIPsSPDLKKS		intracellular localization				1713111	1	6	0		
Fer	EC 2.7.10.2; KINASE; Kinase, protein; Protein kinase, TK; Protein kinase, tyrosine (non-receptor)	P16591	2241	FER	5q21	human	Y714	PHOSPHORYLATION	448461	RQEDGGVySSSGLKQ	Pkinase_Tyr	enzymatic activity, induced				6277001	2	23	639		
KIR3DL1	Membrane protein, integral; Receptor, misc.	P43629	3811	KIR3DL1	19q13.4	human	S388	PHOSPHORYLATION	990303	RTANSEDsDEQDPEE		activity, induced; receptor internalization, altered				970025	1	0	0		
MARK3 iso3	EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, CAMK; Protein kinase, Ser/Thr (non-receptor)	P27448-3	4140	MARK3	14q32.3	human	S96	PHOSPHORYLATION	3597304	KTQLNPTsLQKLFRE	Pkinase	enzymatic activity, inhibited				8987	1	0	0		
IKKB	EC 2.7.11.10; KINASE; Kinase, protein; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor)	O14920	3551	IKBKB	8p11.2	human	S181	PHOSPHORYLATION	447489	DQGSLCTsFVGTLQY	Pkinase	activity, induced; protein stabilization; intracellular localization; enzymatic activity, induced	cell motility, altered; transcription, altered	IKKA(INDUCES)		1736; 6804602; 8475002; 7644600; 6379; 12139; 813	50	0	0		
EphB2	EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Protein kinase, TK; Protein kinase, tyrosine (receptor)	P54763	13844	Ephb2		mouse	Y604	PHOSPHORYLATION	448326	MTPGMKIyIDPFTYE		molecular association, regulation; enzymatic activity, induced	cell adhesion, altered; cytoskeletal reorganization	NMDAR1(INDUCES); RASA1(INDUCES); Src(INDUCES)		4888107; 5264; 1052900; 8957	6	13	115		
GRF-1	GTPase activating protein, Rac/Rho; Motility/polarity/chemotaxis; Transcription factor	Q9NRY4	2909	ARHGAP35	19q13.3	human	Y1105	PHOSPHORYLATION	448941	RNEEENIySVPHDST		activity, induced				7698	2	47	3246	increases GAP activity of GRF1/p190 RhoGAP	
PKCE	EC 2.7.11.13; KINASE; Kinase, protein; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor)	Q02156	5581	PRKCE	2p21	human	S350	PHOSPHORYLATION	486055	RSKSAPTsPCDQEIK		phosphorylation				3301203	1	8	0	stimulates phosphorylation of PKCE S346 	
G6PI	Apoptosis; Carbohydrate Metabolism - amino sugar and nucleotide sugar; Carbohydrate Metabolism - glycolysis and gluconeogenesis; Carbohydrate Metabolism - pentose phosphate pathway; Carbohydrate Metabolism - starch and sucrose; Cytokine; EC 5.3.1.9; Isomerase	P06744	2821	GPI	19q13.1	human	S185	PHOSPHORYLATION	455279	GPRVWYVsNIDGTHI	PGI	molecular association, regulation; enzymatic activity, inhibited	cell growth, altered	G6PI(INDUCES)		4395	2	0	0		
SHPS1	Cell adhesion; Cell surface; Membrane protein, integral; Motility/polarity/chemotaxis; Receptor, misc.	P78324	140885	SIRPA	20p13	human	Y496	PHOSPHORYLATION	451115	PEPSFSEyASVQVPR		phosphorylation				3205	5	10	142	Mutation of these 4 tyrosines does not affect JAK2 binding.  However, overexpression of the WT SHPS1 but not the 4 tyrosine to phenylalanine mutation reduces tyrosine phosphorylation of Jak2, STAT5B, and STAT3 and activation of Erk1/2 in response to growth hormone.  Does not affect STAT3 tyrosine phosphorylation in response to LIF agonist.	
NPM-ALK	Kinase, protein; Protein kinase, TK; Protein kinase, tyrosine (receptor)	AAA58698		NPM/ALK		human	Y343	PHOSPHORYLATION	27275115	DIYRASYyRKGGCAM	Pkinase_Tyr	molecular association, regulation; enzymatic activity, induced	carcinogenesis, altered	VAV3(INDUCES); SHP-1(INDUCES)		11387255; 4260503; 14654300	3	2	0	SHP1 phosphatase mediates tyrosine dephosphorylation of ALK	
Tks5	Adaptor/scaffold	O89032	14218	Sh3pxd2a		mouse	Y557	PHOSPHORYLATION	458193	VKYEEPEyDVPAFGF		molecular association, regulation	cell cycle regulation; cell motility, altered; cytoskeletal reorganization	Nck2(INDUCES); Nck1(INDUCES); WASP(INDUCES)		2790302; 9689607	1	3	11		
ERK1	EC 2.7.1.123; EC 2.7.11.24; KINASE; Kinase, protein; Protein kinase, CMGC; Protein kinase, Ser/Thr (non-receptor)	P27361	5595	MAPK3	16p11.2	human	Y204	PHOSPHORYLATION	447543	HTGFLTEyVATRWYR	Pkinase; YukC	activity, induced; protein degradation; molecular association, regulation; intracellular localization; protein conformation; phosphorylation; enzymatic activity, induced	cell motility, induced; cell differentiation, induced; cell motility, altered; cytoskeletal reorganization; transcription, inhibited; cell growth, altered	TACE(INDUCES); ERK2(INDUCES); KSR(INDUCES)		30280005; 7397603; 5487; 902; 7119508; 4313628; 7674; 6121900; 3565; 3406; 7483320; 5884; 899; 11975; 13354722; 6011114; 7839; 13872500; 5708; 3394329; 4018; 6926; 25725907; 7550825; 668; 4914001; 3342623; 3394311; 5930044; 1172804	1014	73	3510	 increase of RhoA and Cdc42 activity, motility, migration, and invasion	
MUTYH	DNA repair; EC 3.2.2.-; Hydrolase; Mitochondrial	Q9UIF7	4595	MUTYH	1p34.1	human	S535	PHOSPHORYLATION	15343401	NFFRSHIsTDAHSLN		protein stabilization; enzymatic activity, induced				15278810	1	1	0		
LIME1	Adaptor/scaffold; Membrane protein, integral	Q9EQR5	72699	Lime1		mouse	Y137	PHOSPHORYLATION	463651	STSSEATySNVGLAA		activity, induced		Grb2(INDUCES)		7885	2	0	2		
SCN2A	Channel, sodium; Membrane protein, integral; Membrane protein, multi-pass	P04775	24766	Scn2a		rat	Y730	PHOSPHORYLATION	1152200	QKCPPCWyKFANMCL		activity, inhibited				970058	1	0	0		
GRB7	Adaptor/scaffold; Motility/polarity/chemotaxis	Q14451	2886	GRB7	17q12	human	Y188	PHOSPHORYLATION	7965100	FRKNFAKyELFKSSP		phosphorylation	cell cycle regulation; cell motility, altered			7889921	1	0	1	; double mutation Grb7 Y188, 338F inhibits phosphorylation of FAK Y397 (Y428 in mouse), Y861 (Y899 in mouse) and PXN Y118; 
involed in tumorigenesis process	
HER2	EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Protein kinase, TK; Protein kinase, tyrosine (receptor)	P04626	2064	ERBB2	17q12	human	Y1196	PHOSPHORYLATION	448676	GAVENPEyLTPQGGA		molecular association, regulation; enzymatic activity, induced	cell motility, altered; transcription, induced; signaling pathway regulation	Crk(INDUCES)		10001310; 2852654; 4215300	7	2	4	SLK activation, cell motility, leadiing to cancer cell invasion	
DAPK1	Apoptosis; Autophagy; EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, CAMK; Protein kinase, Ser/Thr (non-receptor)	P53355	1612	DAPK1	9q21.33	human	S734	PHOSPHORYLATION	454887	NSSRFPPsPLASKPT	AAA_16	enzymatic activity, induced	apoptosis, altered			4348	1	0	6		
FOXO4	DNA binding protein; Transcription factor	P98177	4303	FOXO4	Xq13.1	human	T227	PHOSPHORYLATION	15798100	PAPPEGAtPTSPVGH			carcinogenesis, altered; transcription, altered			15785208	1	2	0		
MCM2	DNA binding protein; EC 3.6.4.12	P49736	4171	MCM2	3q21	human	S53	PHOSPHORYLATION	473058	LPPFEDEsEGLLGTE	MCM2_N	molecular association, regulation	chromatin organization, altered; cell growth, altered		DNA(INDUCES)	9204; 9145	8	5	11	MMCM2 phosphorylated forms are differentially bound to chromatin. 	
HER2	EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Protein kinase, TK; Protein kinase, tyrosine (receptor)	P06494	24337	Erbb2		rat	Y1141	PHOSPHORYLATION	448678	ACSPQPEyVNQSEVQ		molecular association, regulation		Grb2(INDUCES)		1076	9	2	43	This site can mediate transforming signals. 	
CtBP1	Cell cycle regulation; EC 1.1.1.-; Nuclear receptor co-regulator; Oxidoreductase; Transcription, coactivator/corepressor	Q13363	1487	CTBP1	4p16	human	S158	PHOSPHORYLATION	455351	REGTRVQsVEQIREV	2-Hacid_dh; 2-Hacid_dh_C	protein degradation; ubiquitination; intracellular localization; enzymatic activity, inhibited	transcription, induced; transcription, altered			27565312; 4657	4	1	0	attenuates the repressive function of CtBP1 on Bax promoter; Phosphorylation induces cytoplasmic localization (from nucleus).  Phosphorylation reduces co-repressor activity in vivo and inhibits dehydrogenase activity in vitro.	
TGFBR1	EC 2.7.11.30; KINASE; Kinase, protein; Membrane protein, integral; Protein kinase, Ser/Thr (receptor); Protein kinase, TKL; Receptor, misc.	P36897	7046	TGFBR1	9q22	human	T204	PHOSPHORYLATION	4325703	VQRTIARtIVLQESI		phosphorylation; enzymatic activity, induced				4324303	2	0	0		
CD5	Cell surface; Membrane protein, integral	P06127	921	CD5	11q13	human	T436	PHOSPHORYLATION	450130	FHRNHTAtVRSHAEN		activity, induced; receptor internalization, altered				2735	1	0	45		
Bax	Apoptosis; Membrane protein, integral; Mitochondrial	Q07812	581	BAX	19q13.3-q13.4	human	S60	PHOSPHORYLATION	983100	DASTKKLsECLKRIG		intracellular localization				970023	1	0	0		
Akt1	EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor)	P31749	207	AKT1	14q32.32	human	K14	UBIQUITINATION	12723502	VKEGWLHkRGEYIKT	PH	intracellular localization; phosphorylation; enzymatic activity, induced				12517340	1	0	0	promotes Akt membrane recruitment and phosphorylation, resulting in activation	
RBCK1	EC 6.3.2.-; Ligase; UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase	Q62921		Rbck1		rat	T207	PHOSPHORYLATION	2103605	CTFINKPtRPGCEMC	zf-RanBP	protein stabilization				1968300	1	0	0	inhibits self-ubiquitination of RBCK1 in vitro	
SHPS1	Cell adhesion; Cell surface; Membrane protein, integral; Motility/polarity/chemotaxis; Receptor, misc.	P97710	25528	Sirpa		rat	Y477	PHOSPHORYLATION	451114	RPEDTLTyADLDMVH	Bravo_FIGEY	molecular association, regulation		SHP-2(INDUCES)		3309	5	7	26		
Crk	Adaptor/scaffold; Motility/polarity/chemotaxis	Q04929	417553	CRK		chicken	Y240	PHOSPHORYLATION	450357	NLQNGPFyARVIQKR	SH3_2	molecular association, regulation; protein conformation		Abl(DISRUPTS)		2664100	1	5	253		
raptor	Adaptor/scaffold	Q8N122	57521	RPTOR	17q25.3	human	T908	PHOSPHORYLATION	23940710	LPSGRPGtTGPAGAQ		activity, induced				23260336	1	1	0	leading to mTORC1 activation	
Daxx	Apoptosis; Nuclear receptor co-regulator; Transcription, coactivator/corepressor	Q9UER7	1616	DAXX	6p21.3	human	S739	PHOSPHORYLATION	467727	EIIVLSDsD______	Daxx	sumoylation; molecular association, regulation	apoptosis, altered; transcription, altered	SUMO1(INDUCES); PML(INDUCES)		18837528	1	14	0		
tau iso8	Cytoskeletal protein	P10636-8	4137	MAPT	17q21.1	human	S356	O-GlcNAc	5227900	RVQSKIGsLDNITHV	Tubulin-binding	molecular association, regulation; protein conformation		tau iso8(DISRUPTS)		5014001	1	0	0	modulates aggregation of tau filaments	
DYRK2	EC 2.7.12.1; KINASE; Kinase, protein; Protein kinase, CMGC; Protein kinase, dual-specificity	Q92630	8445	DYRK2	12q15	human	S442	PHOSPHORYLATION	11489909	IELLGMPsQKLLDAS	Pkinase	enzymatic activity, induced	apoptosis, altered			11387204	1	0	0	p53-mediated apoptosis	
SIAH1	Apoptosis; Cell development/differentiation; EC 6.3.2.-; EC 6.3.2.19; Ligase; Motility/polarity/chemotaxis; UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase	Q8IUQ4	6477	SIAH1	16q12.1	human	S19	PHOSPHORYLATION	2840508	GTSKCPPsQRVPALT		molecular association, regulation; ubiquitination; activity, inhibited		HIPK2(DISRUPTS)		2831762	1	0	0	facilitates HIPK2 polyubiquitination	
HSPC227	Adaptor/scaffold	Q9CZG9	72621	Pdzd11		mouse	Y10	PHOSPHORYLATION	451588	NRIPYDDyPVVFLPA		molecular association, regulation		DECR1(INDUCES); ACAA2(INDUCES); TCERG1(INDUCES)		1814200	0	11	139		
MAF1	Transcription regulation	Q9H063	84232	MAF1	8q24.3	human	S68	PHOSPHORYLATION	3211920	PPQTSGLsPSRLSKS	Maf1	activity, inhibited	transcription, induced			12778829; 14780536	2	7	0		
AurA	EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor)	A5GFW1		AURKA		pig	S284	PHOSPHORYLATION	2370900	WSVHAPSsRRTTLCG	Pkinase		cell cycle regulation			3309525	2	0	0		
PLCB1	Carbohydrate Metabolism - inositol phosphate; EC 3.1.4.11; Phospholipase	P10687	24654	Plcb1		rat	S887	PHOSPHORYLATION	450172	HSQPAPGsVKAPAKT		activity, inhibited				2793	3	0	0		
MEK5	EC 2.7.12.2; KINASE; Kinase, protein; Protein kinase, STE; Protein kinase, dual-specificity	Q13163	5607	MAP2K5	15q23	human	T315	PHOSPHORYLATION	448622	LVNSIAKtYVGTNAY	Pkinase	molecular association, regulation; intracellular localization; enzymatic activity, induced		ERK5(DISRUPTS)		5457; 2642	2	0	0	MEK5-alpha isoform, not beta	
CSFR	EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Protein kinase, TK; Protein kinase, tyrosine (receptor)	P09581	12978	Csf1r		mouse	Y706	PHOSPHORYLATION	451528	NIHLEKKyVRRDSGF	Pkinase_Tyr	activity, induced; enzymatic activity, induced	cytoskeletal reorganization			4651302; 3760; 2852611; 7325702	12	0	0		
BAD	Apoptosis	O35147	64639	Bad		rat	S113	PHOSPHORYLATION	447860	ETRSRHSsYPAGTEE	Bcl-2_BAD	molecular association, regulation	apoptosis, altered	14-3-3 beta(INDUCES); Bcl-xL(DISRUPTS)		7644606; 6757	113	9	164		
TrkB	EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Protein kinase, TK; Protein kinase, tyrosine (receptor)	P15209	18212	Ntrk2		mouse	S478	PHOSPHORYLATION	478364	SNDDDSAsPLHHISN		molecular association, regulation	cytoskeletal reorganization	Tiam1(INDUCES)		9592; 27132455	2	2	0	 impaired hippocampal LTP, and impaired memory in water maize and novel object recognition ; dendritic spine density in response to BDNF; dendritic growth	
PCNA	Cell cycle regulation	P17918	18538	Pcna		mouse	Y114	PHOSPHORYLATION	27281500	NQEKVSDyEMKLMDL	PCNA_N		cell cycle regulation; cell differentiation, induced			27258200	1	0	0	Y114F +/+ mutant does not re-enter cell cycle for clonal expansion.  Y114F+/+ mice are is resistant to diet-induced obesity compared to WT. 	
LIMK2	EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, Ser/Thr (non-receptor); Protein kinase, TKL	P53671	3985	LIMK2	22q12.2	human	S283	PHOSPHORYLATION	456167	EGTLRRRsLRRSNSI		intracellular localization				6612; 8149	3	0	10	phosphorylation of this site inhibits the nuclear import of LIMK2; its phosphorylation inhibits the nuclear import of LIMK2	
eIF2B-epsilon	Translation; Translation initiation	Q13144	8893	EIF2B5	3q27.1	human	S525	PHOSPHORYLATION	470490	KINMEEEsESESEQS		activity, induced	translation, altered			1713153	1	1	0	eIF2B-epsilon [S525A] mutation abolished regulation of protein synthesis by amino acids	
Bim	Apoptosis	O54918	12125	Bcl2l11		mouse	T112	PHOSPHORYLATION	449071	SCDKSTQtPSPPCQA		molecular association, regulation	apoptosis, altered; apoptosis, induced	Bcl-2(INDUCES)		2915501; 11189915	8	0	0	required for normal lymphocyte homeostasis	
ANPA	EC 4.6.1.2; Guanylyl cyclase; KINASE; Kinase, protein; Lyase; Membrane protein, integral; Nucleotide Metabolism - purine; Protein kinase, RGC; Protein kinase, dual-specificity; Receptor, misc.	P16066	4881	NPR1	1q21-q22	human	S529	PHOSPHORYLATION	447512	RHLRSAGsRLTLSGR		activity, induced				896	2	3	0		
GNAT1	G protein; G protein, heterotrimeric; G protein, heterotrimeric alpha G((i/o/t/z))	P04695	281794	GNAT1		cow	Y142	PHOSPHORYLATION	470102	CFDRASEyQLNDSAG	G-alpha	molecular association, regulation		Src(INDUCES)		8859	1	1	0	Tyrosine phosphorylation of GNAT1 increases association with Src.	
MCM2	DNA binding protein; EC 3.6.4.12	P49736	4171	MCM2	3q21	human	S27	PHOSPHORYLATION	452310	GNDPLTSsPGRSSRR		activity, induced; molecular association, regulation	cell cycle regulation; chromatin organization, altered		DNA(NOT_REPORTED); DNA(INDUCES)	2205200; 9204	3	51	57	MMCM2 phosphorylated forms are differentially bound to chromatin. ; regulates ATPase activity in vitro	
ERK2	EC 2.7.11.24; KINASE; Kinase, protein; Protein kinase, CMGC; Protein kinase, Ser/Thr (non-receptor)	P63085	26413	Mapk1		mouse	T188	PHOSPHORYLATION	3949250	FLTEYVAtRWYRAPE	Pkinase; YukC	intracellular localization	cytoskeletal reorganization; cell growth, altered			6842222	1	8	21	T 188 phosphorylation induces ERK nuclear localization and cardiac hypertrophy.	
Oct7	DNA binding protein; Motility/polarity/chemotaxis; Transcription factor	P31360	18992	Pou3f2		mouse	T361	PHOSPHORYLATION	22996304	GRKRKKRtSIEVSVK	Homeobox		cell cycle regulation; cell motility, induced; transcription, induced			22958929	1	0	0	mutation of this site inhibits PAX3 transcription, but not MITF-M transcription	
DNAPK	DNA repair; EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, ATYPICAL; Protein kinase, Ser/Thr (non-receptor)	P78527	5591	PRKDC	8q11	human	S2056	PHOSPHORYLATION	455794	VQSYSYSsQDPRPAT	NUC194		chromatin organization, altered; cell growth, altered			9570	18	0	3	increases survival in ionizing radiation and repairing double strand DNA breaks	
p21Cip1	Cell cycle regulation; Inhibitor protein	P38936	1026	CDKN1A	6p21.2	human	K154	UBIQUITINATION	9897005	MTDFYHSkRRLIFSK		protein degradation; ubiquitination				5669	2	0	0	UV-induced 	
SLP76	Adaptor/scaffold	Q13094	3937	LCP2	5q35.1	human	S376	PHOSPHORYLATION	476784	SSFPQSAsLPPYFSQ		protein degradation; molecular association, regulation; ubiquitination	transcription, altered	14-3-3 zeta(INDUCES); 14-3-3 epsilon(INDUCES); 14-3-3 gamma(INDUCES)		25712655; 9402	3	0	0		
Met	EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Protein kinase, TK; Protein kinase, tyrosine (receptor)	P16056	17295	Met		mouse	Y1228	PHOSPHORYLATION	448866	FGLARDMyDKEYYSV	Pkinase_Tyr	enzymatic activity, induced				9721216	5	7	100		
BARD1	EC 6.3.2.-; EC 6.3.2.19; Ligase; Tumor suppressor; UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase	Q99728	580	BARD1	2q34-q35	human	T394	PHOSPHORYLATION	455773	FISLSPGtPPSTLSS			cell cycle regulation			5849	1	6	1	resistance to genotoxic stress (mitomycin C)	
TOP2A	EC 5.99.1.3; Isomerase	P11388	7153	TOP2A	17q21-q22	human	S1213	PHOSPHORYLATION	452237	QMAEVLPsPRGQRVI		intracellular localization				6562	4	31	6		
ROMK	Channel, potassium; Membrane protein, integral; Membrane protein, multi-pass	P35560	24521	Kcnj1		rat	S44	PHOSPHORYLATION	449605	RQRARLVsKEGRCNI	IRK	activity, induced; intracellular localization; protein conformation				6702; 3004; 2451817	8	0	0		
p53	Activator protein; DNA binding protein; Motility/polarity/chemotaxis; Nuclear receptor co-regulator; Transcription factor; Tumor suppressor	P04637	7157	TP53	17p13.1	human	T55	PHOSPHORYLATION	450685	DDIEQWFtEDPGPDE	DEC-1_N	activity, induced; protein degradation; molecular association, regulation; intracellular localization	cell cycle regulation; apoptosis, altered; transcription, altered	TFB1M(INDUCES); MDM2(INDUCES); GTF2H1(NOT_REPORTED); exportin 1(INDUCES); GTF2H1(INDUCES)		1968315; 3548; 7236; 6468; 6271038; 8071; 13788304	14	0	0		
capicua	DNA binding protein; Transcription factor	Q96RK0	23152	CIC	19q13.2	human	S173	PHOSPHORYLATION	3209781	PGKRRTQsLSALPKE		molecular association, regulation	transcription, altered	14-3-3 epsilon(INDUCES)		17431533	1	14	9		
cofilin 1	Cytoskeletal protein; Motility/polarity/chemotaxis	P10668	445532	COFILIN		pig	S3	PHOSPHORYLATION	448444	_____MAsGVAVSDG		molecular association, regulation	cytoskeletal reorganization	ACTB(DISRUPTS)		4196	52	32	2	S3D mutant disrupts colocalization with actin. S3D mutant fails to rescue  cof-1-defective mutant of budding yeast. 	
JAK2	EC 2.7.10.2; KINASE; Kinase, protein; Protein kinase, TK; Protein kinase, tyrosine (non-receptor)	Q62120	16452	Jak2		mouse	Y221	PHOSPHORYLATION	451493	VRAKIQDyHILTRKR		enzymatic activity, induced				3674	9	5	1		
OTUB1	EC 3.1.2.-; EC 3.4.-.-; EC 3.4.19.12; Protease; Ubiquitin conjugating system; Ubiquitin-specific protease	Q96FW1	55611	OTUB1	11q13.1	human	Y26	PHOSPHORYLATION	14821305	EGVNCLAyDEAIMAQ	Lipoprotein_7	molecular association, regulation		YpkA(INDUCES)		14790313	1	2	0	regulates bacterial uptake 	
DCP1A	EC 3.-.-.-; Hydrolase; RNA processing; Transcription, coactivator/corepressor	Q91YD3	75901	Dcp1a		mouse	S335	PHOSPHORYLATION	3213294	PSYTLPLsPVLSPTL		molecular association, regulation		DCP2(INDUCES)		27902366	3	15	8		
ADD2	Cytoskeletal protein; Motility/polarity/chemotaxis	P35612	119	ADD2	2p13.3	human	Y489	PHOSPHORYLATION	449419	PNQFVPLyTDPQEVL		intracellular localization				8175	2	3	162		
FOXO1A	DNA binding protein; Nuclear receptor co-regulator; Transcription factor	G3V7R4	84482	Foxo1		rat	S206	PHOSPHORYLATION	4258803	SSAGWKNsIRHNLSL	Fork_head	molecular association, regulation; intracellular localization	apoptosis, induced	14-3-3 beta(DISRUPTS)		7889911	2	0	0	total 14-3-3 proteins	
Grb10	Adaptor/scaffold	Q13322	2887	GRB10	7p12.2	human	T155	PHOSPHORYLATION	22312200	PGSPPVLtPGSLPPS		protein stabilization				19044700	1	0	0		
ARHGEF7	Guanine nucleotide exchange factor, Rac/Rho; Motility/polarity/chemotaxis	O55043	114559	Arhgef7		rat	T526	PHOSPHORYLATION	455216	EFAVRKStAALEEDA		molecular association, regulation; intracellular localization	cytoskeletal reorganization	14-3-3 beta(INDUCES)		1713154; 4425	6	4	1	binding to 14-3-3 beta requires protein dimerization; translocated to Focal complexes	
SH3BP4	Cell cycle regulation; Vesicle protein	Q921I6	98402	Sh3bp4		mouse	S245	PHOSPHORYLATION	3214461	FRSKRSYsLSELSVL		molecular association, regulation		14-3-3 beta(INDUCES)		6337814	1	13	0		
NFAT90	DNA binding protein; Transcription factor	Q9Z1X4	16201	Ilf3		mouse	T315	PHOSPHORYLATION	17734000	RQQREDItQSAQHAL	DZF	molecular association, regulation; intracellular localization	translation, altered	ILF2(DISRUPTS)		17675013	1	0	0		
IREM-1	Immunoglobulin superfamily; Membrane protein, integral; Receptor, misc.	Q8TDQ1	146722	CD300LF	17q25.1	human	Y236	PHOSPHORYLATION	474548	VDQVEVEyVTMASLP		activity, induced; molecular association, regulation		PIK3R1(INDUCES)		9304	1	0	0	involved in rat basophilic leukemia cell degranulation	
TAK1	EC 2.7.11.25; KINASE; Kinase, protein; Protein kinase, Ser/Thr (non-receptor); Protein kinase, TKL	Q62073	26409	Map3k7		mouse	S192	PHOSPHORYLATION	448289	HMTNNKGsAAWMAPE	Pkinase_Tyr	enzymatic activity, induced		TAB1(INDUCES)		1298	4	0	0		
IGF1R	EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Protein kinase, TK; Protein kinase, tyrosine (receptor)	P08069	3480	IGF1R	15q26.3	human	Y1346	PHOSPHORYLATION	448389	SFDERQPyAHMNGGR		molecular association, regulation; enzymatic activity, induced	cell differentiation, altered; cell growth, altered	Src(INDUCES)		2703; 6783	3	6	22	observed in quadruple mutant Y980/1280/1281/1346F	
p53	Activator protein; DNA binding protein; Motility/polarity/chemotaxis; Nuclear receptor co-regulator; Transcription factor; Tumor suppressor	P04637	7157	TP53	17p13.1	human	K382	UBIQUITINATION	464658	QSTSRHKkLMFKTEG		protein degradation; intracellular localization	transcription, inhibited			12136; 7920	11	0	0	K370/372/373/381/382/386/R mutant shows 613-fold activation of p53	
Chk2	EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, CAMK; Protein kinase, Ser/Thr (non-receptor)	O96017	11200	CHEK2	22q12.1	human	S210	PHOSPHORYLATION	12473000	DLTVDDQsVYPKALR		enzymatic activity, inhibited	cell cycle regulation			12190200	1	1	0	mutation of this site impairs checkpoint recovery	
vimentin	Cytoskeletal protein; Motility/polarity/chemotaxis	P08670	7431	VIM	10p13	human	S26	PHOSPHORYLATION	451767	GTASRPSsSRSYVTT	Filament_head; DUF2464	molecular association, regulation	cytoskeletal reorganization	vimentin(DISRUPTS)		2214	3	3	0		
NPM1	RNA binding protein; Translation	P06748	4869	NPM1	5q35.1	human	S10	PHOSPHORYLATION	7105368	DSMDMDMsPLRPQNY		molecular association, regulation; intracellular localization; phosphorylation	cell cycle regulation	Cdc25C(INDUCES)		11424230	1	9	0	mutation of S10/S70 to alanine increases CDK1 Y15 phosphorylation;  mutation of S10/70 to glutamate decreases Cdc25C S216 phosphorylation	
TRPM8	Channel, cation; Membrane protein, integral; Membrane protein, multi-pass	Q7Z2W7	79054	TRPM8	2q37.1	human	T17	PHOSPHORYLATION	12570902	MRNRRNDtLDSTRTL		activity, induced				12525219	1	0	0		
H3	DNA binding protein	P68431	8350	HIST1H3A	6p22.1	human	K10	TRI-METHYLATION	1458613	RTKQTARkSTGGKAP		molecular association, regulation		UHRF1(INDUCES)		20989500	86	3	1	fluorescence polarization binding assay,  
H3K5me3/K10me3 showed a 5-fold lower affinity compared with the H354me0/K10me3 peptide.	
p90RSK	EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor); Translation	Q15418	6195	RPS6KA1	1p	human	T359	PHOSPHORYLATION	447992	DTEFTSRtPKDSPGI	Pkinase_C	enzymatic activity, induced				30280007	35	11	2		
DDR1	EC 2.7.1.112; EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Protein kinase, TK; Protein kinase, tyrosine (receptor)	Q08345	780	DDR1	6p21.3	human	Y703	PHOSPHORYLATION	462887	PLCMITDyMENGDLN	Pkinase_Tyr	molecular association, regulation		SHP-2(INDUCES)		7860	1	0	0	required for the DDR1-mediated suppression of tyrosine phosphorylation of Stat1 and Stat3, cell migration, branching tubulogenesis	
Mnk1	EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, CAMK; Protein kinase, Ser/Thr (non-receptor); Translation	O08605	17346	Mknk1		mouse	T209	PHOSPHORYLATION	447621	NSCTPITtPELTTPC	Pkinase	molecular association, regulation; enzymatic activity, induced		eIF4G(INDUCES)		2340	11	0	1		
HDAC9	DEACETYLASE; Deacetylase; EC 3.5.1.98; Transcription, coactivator/corepressor	Q9UKV0	9734	HDAC9	7p21.1	human	S220	PHOSPHORYLATION	448485	FPLRKTAsEPNLKVR		molecular association, regulation; intracellular localization		14-3-3 beta(INDUCES)		13164207	2	8	17		
Bim	Apoptosis	O43521	10018	BCL2L11	2q13	human	T116	PHOSPHORYLATION	449071	SCDKSTQtPSPPCQA		molecular association, regulation	autophagy, induced	LC8(DISRUPTS); beclin 1(DISRUPTS)		25712639	8	0	0		
GluR2	Channel, calcium; Channel, ligand-gated; Membrane protein, integral; Membrane protein, multi-pass	P19491	29627	Gria2		rat	S880	PHOSPHORYLATION	448351	YNVYGIEsVKI____		molecular association, regulation; intracellular localization; receptor internalization, altered; receptor recycling, altered; activity, inhibited		GRIP1(DISRUPTS)		3433203; 2689; 8618; 7613731; 9227; 1704	20	1	0		
HIPK2	EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, CMGC; Protein kinase, Ser/Thr (non-receptor)	Q9H2X6	28996	HIPK2	7q32-q34	human	K671	UBIQUITINATION	3059904	GLQASPSkHAGYSVR		protein degradation				2831762	1	0	0		
GYS1	Carbohydrate Metabolism - starch and sucrose; EC 2.4.1.11; Transferase	P13834	100008660	GYS1		rabbit	S8	PHOSPHORYLATION	449898	MPLSRTLsVSSLPGL		enzymatic activity, inhibited				4917204; 3738	15	1	0		
MMP14	EC 3.4.24.80; Membrane protein, integral; Motility/polarity/chemotaxis; Protease	P50281	4323	MMP14	14q11.2	human	Y573	PHOSPHORYLATION	478362	GTPRRLLyCQRSLLD	DUF3377	intracellular localization	cell cycle regulation; carcinogenesis, altered; cell motility, altered; transcription, induced; cell growth, altered			3309514; 27902331; 14790311; 9625; 9201016	7	2	39	peptide antagonist (ACM-14) carrying mutation (Y573F) of this site inhibits tumor cell proliferation ; MMP14 overexpression induces CSF-2, CSF-3 gene expression and requires Y573-p.	
FAK iso3	EC 2.7.1.112; EC 2.7.10.2; KINASE; Kinase, protein; Protein kinase, TK; Protein kinase, tyrosine (non-receptor)	P34152-3	14083	Ptk2		mouse	S843	PHOSPHORYLATION	447963	DVRLSRGsIDREDGS		phosphorylation				5513	7	8	7	decreases phosphorylation at FAK Tyr397	
STF-1	Nuclear receptor	Q13285	2516	NR5A1	9q33	human	S203	PHOSPHORYLATION	447603	EYPEPYAsPPQPGLP		activity, induced	transcription, induced			762737; 8800	9	0	0	Mutations which inhibit phospholipid binding reduce STF-1 phosphorylation.	
pyrin		O15553	4210	MEFV	16p13.3	human	S242	PHOSPHORYLATION	455899	SGKMRPRsLEVTIST		molecular association, regulation; intracellular localization		14-3-3 theta(INDUCES)		6362	1	2	0		
FPR1	GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Motility/polarity/chemotaxis; Receptor, GPCR	P21462	2357	FPR1	19q13.4	human	T336	PHOSPHORYLATION	450844	TQTSDTAtNSTLPSA		receptor desensitization, altered; receptor internalization, altered				3130	2	0	0		
NACA	Motility/polarity/chemotaxis; Transcription, coactivator/corepressor	E9PAV3	4666	NACA	12q23-q24.1	human	T2022	PHOSPHORYLATION	451197	NIQENTQtPTVQEES		protein stabilization; intracellular localization	transcription, altered			3384	1	7	0		
SLAP-130	Adaptor/scaffold	O15117	2533	FYB	5p13.1	human	Y780	PHOSPHORYLATION	459246	DIADGCIyDND____			cell adhesion, altered			15020906	1	1	27	promotes adhesion to ICAM-1	
Chk1	EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, CAMK; Protein kinase, Ser/Thr (non-receptor)	O35280	12649	Chek1		mouse	S301	PHOSPHORYLATION	465528	IHSNLDFsPVNNGSS		intracellular localization				11419348	5	9	1		
HDAC9	DEACETYLASE; Deacetylase; EC 3.5.1.98; Transcription, coactivator/corepressor	Q9UKV0	9734	HDAC9	7p21.1	human	S451	PHOSPHORYLATION	448486	RPLNRTQsAPLPQST		molecular association, regulation; intracellular localization		14-3-3 beta(INDUCES)		13164207	2	2	5		
CCNB1	Activator protein; Cell cycle regulation	P14635	891	CCNB1	5q12	human	S116	PHOSPHORYLATION	13256100	PVKEEKLsPEPILVD	Trypan_PARP	intracellular localization			DNA(INDUCES)	25573559; 12778806	2	1	0	enhances nuclear import	
APP iso8	Apoptosis; Cell surface; Membrane protein, integral; Receptor, misc.; Transcription factor	P05067-8	351	APP	21q21.3	human	Y743	PHOSPHORYLATION	450343	NGYENPTyKFFEQMQ	APP_amyloid	protein processing				3093	4	6	238		
MDM4	EC 6.3.2.-; Ligase; UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase	O15151	4194	MDM4	1q32	human	S96	PHOSPHORYLATION	455615	SFSVKDPsPLYDMLR	SWIB	intracellular localization				5500	1	0	0		
SIAH1	Apoptosis; Cell development/differentiation; EC 6.3.2.-; EC 6.3.2.19; Ligase; Motility/polarity/chemotaxis; UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase	Q8IUQ4	6477	SIAH1	16q12.1	human	Y100	PHOSPHORYLATION	457101	SVLFPCKyASSGCEI	Sina	protein stabilization	apoptosis, altered			7019	1	0	0		
TSC2 iso2	Cell cycle regulation; GTPase activating protein, misc.; Nuclear receptor co-regulator; Tumor suppressor	P49816-2	24855	Tsc2		rat	S1211	PHOSPHORYLATION	448807	TALYKSLsVPAAGTA		molecular association, regulation		14-3-3 beta(INDUCES)		1974	4	8	14		
CDK16	EC 2.7.11.22; KINASE; Kinase, protein; Motility/polarity/chemotaxis; Protein kinase, CMGC; Protein kinase, Ser/Thr (non-receptor)	Q04735	18555	Cdk16		mouse	S153	PHOSPHORYLATION	453451	SRRLRRVsLSEIGFG		molecular association, regulation; intracellular localization		CBCP1(DISRUPTS)		22723904	2	29	130		
Bex1	Cell cycle regulation; Cell development/differentiation	Q3MKQ2	501625	Bex1		rat	S105	PHOSPHORYLATION	14788300	KLRERQLsHSLRAVS	BEX	protein stabilization				12482276	1	0	0		
Bim	Apoptosis	O43521	10018	BCL2L11	2q13	human	S87	PHOSPHORYLATION	458219	FIFMRRSsLLSRSSS			apoptosis, altered			7311	1	3	1		
NDR1	EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor)	Q15208	11329	STK38	6p21	human	T74	PHOSPHORYLATION	460658	SAHARKEtEFLRLKR		molecular association, regulation; phosphorylation	cytoskeletal reorganization	S100B(INDUCES); MOB1A(INDUCES); MOB1B(NOT_REPORTED)		1998; 12066004	2	0	0	NDR1 Y31A and Y74A mutants showed highly decreased T444 phosphorylation and centrosome amplification.	
LAIR-1	Membrane protein, integral; Receptor, misc.	Q6GTX8	3903	LAIR1	19q13.4	human	Y251	PHOSPHORYLATION	449020	GSSQEVTyAQLDHWA		molecular association, regulation		SHP-1(INDUCES)		2177	1	0	28		
K18	Cytoskeletal protein	P05783	3875	KRT18	12q13	human	S34	PHOSPHORYLATION	447733	RPVSSAAsVYAGAGG		molecular association, regulation; intracellular localization	cytoskeletal reorganization	14-3-3 beta(INDUCES); 14-3-3 zeta(INDUCES)		7313818; 1030; 5411; 3059	12	15	10		
PINX1	Inhibitor protein	Q96BK5	54984	PINX1	8p23	human	S226	PHOSPHORYLATION	14823405	ATGKDVEsYLQPKAK		protein degradation; ubiquitination				14790317	1	1	0		
CKAP4	Endoplasmic reticulum; Membrane protein, integral	Q07065	10970	CKAP4	12q23.3	human	S17	PHOSPHORYLATION	455354	KGGHGAAsPSEKGAH			cytoskeletal reorganization			4595	3	4	0	Mutation of S3, S17 and S19 to glutamate leads to a collapse of the endoplasmic reticulum around the nucleus in interphase cells.	
FAM125B	Vesicle protein	Q9H7P6	89853	FAM125B	9q33.3	human	Y241	PHOSPHORYLATION	6209987	RNSTRTDyEYQHSNL	DUF2464	protein degradation; ubiquitination				15026112	1	0	2		
EphB2	EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Protein kinase, TK; Protein kinase, tyrosine (receptor)	P54763	13844	Ephb2		mouse	Y938	PHOSPHORYLATION	448334	EAIKMGQyKESFANA	SAM_1	molecular association, regulation		Grb10(INDUCES)		10144215	3	2	0	necessary for binding to Grb10 SH2, but not Grb2.	
p70S6K	EC 2.7.11.-; EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor); Translation	Q8BSK8	72508	Rps6kb1		mouse	T444	PHOSPHORYLATION	448358	RFIGSPRtPVSPVKF		molecular association, regulation; enzymatic activity, induced	cell differentiation, altered	DEDD(INDUCES)		7119509; 5011211	94	16	84		
NCAM-L1	Cell adhesion; Membrane protein, integral	P32004	3897	L1CAM	Xq28	human	S1181	PHOSPHORYLATION	465573	GEYRSLEsDNEEKAF	Bravo_FIGEY	intracellular localization; phosphorylation	cell motility, altered; cytoskeletal reorganization			9985921; 9593; 9177	4	11	5	axonal growth	
FXR1	RNA binding protein; Translation	P51114	8087	FXR1	3q28	human	S420	PHOSPHORYLATION	467926	SERKDELsDWSLAGE	FXR1P_C	intracellular localization				14058617	1	14	24		
CDCP1	Cell surface; Membrane protein, integral	Q9H5V8	64866	CDCP1	3p21.31	human	Y734	PHOSPHORYLATION	451434	KDNDSHVyAVIEDTM		molecular association, regulation; intracellular localization; phosphorylation	cell motility, altered	Src(INDUCES); PKCD(INDUCES)		3637; 14821612; 5517	6	3	13	regulates migration, invasion, and extracellular matrix degradation	
HSP20	Chaperone	Q5EBG6	243912	Hspb6		mouse	S16	PHOSPHORYLATION	450706	PSWLRRAsAPLPGFS	Crystallin	molecular association, regulation	apoptosis, altered	HSP20(DISRUPTS)		11270020; 15604200	15	17	2		
PSEN1	Cell surface; EC 3.4.23.-; Membrane protein, integral; Membrane protein, multi-pass; Mitochondrial; Protease	P49768	5663	PSEN1	14q24.3	human	S353	PHOSPHORYLATION	448562	SHLGPHRsTPESRAA	Presenilin	molecular association, regulation; intracellular localization; protein conformation	cell growth, altered	CTNNB1(DISRUPTS); CDH2(DISRUPTS); CTNNB1(INDUCES)		9615; 9608; 1674	3	0	3	;  GSK3beta activation downregulates PI3K/Akt signaling probably by reducing the interaction of PSEN1 with N-cadherin (CDH2)/ beta catenin (CTNNB1); reduced interaction was observed in the constitutively active GSK3beta (S9A) mutant; stabilizes beta catenin by reducing its ubiquitination and turn-over 	
GATA1	DNA binding protein; Transcription factor	P17679	14460	Gata1		mouse	S26	PHOSPHORYLATION	451232	VDSALVSsPSDSTGF		activity, induced; molecular association, regulation	apoptosis, inhibited; transcription, induced	LMO2(INDUCES)		6360; 8522	5	0	0		
NKCC2	Membrane protein, integral; Membrane protein, multi-pass; Transporter	P55014	20495	Slc12a1		mouse	T101	PHOSPHORYLATION	458228	LQTFGHNtMDAVPKI	AA_permease_N	activity, induced				7338	7	2	0		
p53	Activator protein; DNA binding protein; Motility/polarity/chemotaxis; Nuclear receptor co-regulator; Transcription factor; Tumor suppressor	P04637	7157	TP53	17p13.1	human	K372	ACETYLATION	458982	HSSHLKSkKGQSTSR			apoptosis, induced; transcription, altered			2790309; 7647800	16	3	0	 ; ZNF420 (Apak) represses p53 activity by attenuating its acetylation ;  p53 8KR mutant can be still degraded by Mdm2; p53 8KR mutation (K120/164/370/372/373/381/382/386R) impairs p53-dependent transcription	
CCNE2	Activator protein; Cell cycle regulation	O96020	9134	CCNE2	8q22.1	human	T74	PHOSPHORYLATION	5996402	SPCIIIEtPHKEIGT		protein degradation; ubiquitination				5930031	1	0	2		
LHR	GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR	P16235	25477	Lhcgr		rat	S675	PHOSPHORYLATION	451064	KNGFPGAsKPSQATL		receptor internalization, altered				3286	1	0	0	S675 is essential for agonist-induced internalization but not for agonist-induced uncoupling.   	
STAT5B	DNA binding protein; Transcription factor	P51692	6777	STAT5B	17q11.2	human	Y743	PHOSPHORYLATION	448736	PQAHYNMyPQNPDSV		activity, inhibited	transcription, altered; transcription, inhibited			9052; 1172807	3	0	0	transcriptional activation of STAT5B Y740/743 mutant requires phosphorylation of S731 and Y699	
STAT1	DNA binding protein; Transcription factor	Q9QXK0	25124	Stat1		rat	Y701	PHOSPHORYLATION	447754	DDPKRTGyIKTELIS		activity, induced	apoptosis, inhibited; transcription, altered			4757; 6401	124	4	61		
ARPC1B	Cytoskeletal protein; Motility/polarity/chemotaxis	O15143	10095	ARPC1B	7q22.1	human	T21	PHOSPHORYLATION	10349703	HAWNKDRtQIAICPN	TFIIIC_delta	molecular association, regulation; phosphorylation	cell cycle regulation; cell motility, altered; cytoskeletal reorganization	ARPC2(INDUCES); ARP2(INDUCES)		15173401; 10144220	2	1	0	stimulates T288 AurA phosphorylation and its activation	
AHCYL1	Amino Acid Metabolism - cysteine and methionine; EC 3.3.1.1; Hydrolase; Other Amino Acids Metabolism - selenoamino acid	Q80SW1	229709	Ahcyl1		mouse	S77	PHOSPHORYLATION	467249	SSTDSYSsAASYTDS	Utp11	molecular association, regulation		IP3R1(INDUCES)		8190	2	0	0	binding to IP3R1 supresses its binding to IP3 and inhibits IP3-induced calcium release 	
MKK6	EC 2.7.12.2; KINASE; Kinase, protein; Protein kinase, STE; Protein kinase, dual-specificity	P52564	5608	MAP2K6	17q24.3	human	T211	ACETYLATION	4325702	LVDSVAKtIDAGCKP	Pkinase	enzymatic activity, inhibited; phosphorylation				4324302	1	0	0	yopJ inhibits MKK6 phosphorylation and its enzymatic activation in vitro	
p53	Activator protein; DNA binding protein; Motility/polarity/chemotaxis; Nuclear receptor co-regulator; Transcription factor; Tumor suppressor	P02340	22059	Tp53		mouse	S55	PHOSPHORYLATION	2624500	EEFFEGPsEALRVSG			apoptosis, inhibited; transcription, induced			7124727; 2624101	2	0	0	crucial for induction of transcription of p21, SESN2, Bbc3, and Bax; HIPK2 induced apoptosis is p53 dependent.	
RSK2	EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor)	P51812	6197	RPS6KA3	Xp22.2-p22.1	human	S369	PHOSPHORYLATION	448064	TAKTPKDsPGIPPSA	Pkinase_C	protein conformation; enzymatic activity, induced	transcription, induced			4577; 11751	9	20	19		
Abl	EC 2.7.1.112; EC 2.7.10.2; KINASE; Kinase, protein; Protein kinase, TK; Protein kinase, tyrosine (non-receptor)	P00519	25	ABL1	9q34.1	human	Y393	PHOSPHORYLATION	450298	RLMTGDTyTAHAGAK	Pkinase_Tyr	enzymatic activity, induced	transcription, altered; cell growth, altered			6274; 2852626	18	34	1682		
CRYAB	Chaperone	P02511	1410	CRYAB	11q22.3-q23.1	human	S19	PHOSPHORYLATION	447728	RPFFPFHsPSRLFDQ	Crystallin	activity, induced; protein degradation; molecular association, regulation; intracellular localization; protein conformation		CRYAB(DISRUPTS); FBX4(INDUCES)		1172875; 8402; 5906; 1977; 8239	15	11	2	increased chaperone-like activity and subunit exchange in vitro	
caveolin-2	Adaptor/scaffold; Motility/polarity/chemotaxis	NP_571989	363425	Cav2		rat	Y27	PHOSPHORYLATION	454430	SHHSVVDyTDPEKYV	Caveolin	intracellular localization; phosphorylation				7910522	5	8	28	stimulates phosphorylation of STAT3 S727/Y705	
PR	DNA binding protein; Nuclear receptor	P06401	5241	PGR	11q22-q23	human	S345	PHOSPHORYLATION	450157	AFAPPRSsPCASSTP	Prog_receptor	molecular association, regulation	transcription, induced	SP1(INDUCES)		1968334; 7324125	6	1	0		
TIRAP	Adaptor/scaffold	P58753	114609	TIRAP	11q24.2	human	Y106	PHOSPHORYLATION	463809	AAQDLVSyLEGSTAS	TIR_2	activity, induced; molecular association, regulation; phosphorylation	transcription, altered	TLR4(DISRUPTS); MYD88(DISRUPTS); Btk(INDUCES)		7871; 1713124	2	0	1		
TNIP1	Transcription regulation	Q15025	10318	TNIP1	5q32-q33.1	human	Y552	PHOSPHORYLATION	25790900	CGAYPYAyPPMPAMV		molecular association, regulation	cell adhesion, induced	SELPLG(INDUCES); PIK3R1(INDUCES)		25785432	1	0	0	activation of alpha-M beta-2 integrin	
NDR1	EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor)	Q15208	11329	STK38	6p21	human	Y31	PHOSPHORYLATION	2526142	KVTLENFySNLIAQH	Alpha-2-MRAP_N	molecular association, regulation; phosphorylation	cytoskeletal reorganization	MOB1A(INDUCES); MOB1B(NOT_REPORTED)		12066004	1	0	8	NDR1 Y31A and Y74A mutants showed highly decreased T444 phosphorylation and centrosome amplification.	
CCR5	GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Motility/polarity/chemotaxis; Receptor, GPCR; Receptor, cytokine	P51681	1234	CCR5	3p21.31	human	Y339	PHOSPHORYLATION	2431400	PERASSVyTRSTGEQ		phosphorylation				2431100	1	0	0	necessary for vaccina virus infection and subsequent ERK, IRS-2, and GRB2 phosphorylation	
FcRL4	Membrane protein, integral	Q96PJ5	83417	FCRL4	1q21	human	Y451	PHOSPHORYLATION	22730002	QVELQSLyVDVHPKK			signaling pathway regulation			22723938	1	0	0	all 3 sites (Y451, Y463, Y493) inhibits BCR signaling and enhances TLR9 signaling	
PAR-4	Apoptosis	Q62627	64513	Pawr		rat	T155	PHOSPHORYLATION	456964	LREKRRStGVVNIPA			apoptosis, induced; transcription, altered			6954	2	0	27		
SHPS1	Cell adhesion; Cell surface; Membrane protein, integral; Motility/polarity/chemotaxis; Receptor, misc.	P78324	140885	SIRPA	20p13	human	Y453	PHOSPHORYLATION	1861200	EPNNHTEyASIQTSP		phosphorylation				3205	4	2	8	Mutation of these 4 tyrosines does not affect JAK2 binding.  However, overexpression of the WT SHPS1 but not the 4 tyrosine to phenylalanine mutation reduces tyrosine phosphorylation of Jak2, STAT5B, and STAT3 and activation of Erk1/2 in response to growth hormone.  Does not affect STAT3 tyrosine phosphorylation in response to LIF agonist.	
Mpl	Membrane protein, integral; Receptor, cytokine	Q08351	17480	Mpl		mouse	T569	PHOSPHORYLATION	3091408	LPKSSEStPLPLCPS		activity, induced; phosphorylation	cell growth, altered			8388	1	0	0	tyrosine phosphorylation of JAK2	
SNX26	GTPase activating protein, Rac/Rho; Vesicle protein	O14559	115703	ARHGAP33	19q13.12	human	Y406	PHOSPHORYLATION	465993	PLLTYQLyGKFSEAM	RhoGAP	activity, inhibited	cell growth, altered			8103	1	0	0		
AMPKB1	Autophagy; Protein kinase, regulatory subunit	P80386	83803	Prkab1		rat	S24	PHOSPHORYLATION	448111	HKTPRRDsSGGTKDG		intracellular localization				1677	4	3	11		
IKKB	EC 2.7.11.10; KINASE; Kinase, protein; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor)	O88351	16150	Ikbkb		mouse	Y188	PHOSPHORYLATION	449632	SFVGTLQyLAPELLE	Pkinase	enzymatic activity, induced	cell differentiation, induced			22881913	4	0	0	osteoclast differentiation	
MARK1	EC 2.7.11.1; EC 2.7.11.26; KINASE; Kinase, protein; Protein kinase, CAMK; Protein kinase, Ser/Thr (non-receptor)	O08678	117016	Mark1		rat	S219	PHOSPHORYLATION	456805	KLDTFCGsPPYAAPE	Pkinase	enzymatic activity, induced				6889	1	6	10		
NCAM1	Cell adhesion; Membrane protein, integral; Motility/polarity/chemotaxis	P13595	17967	Ncam1		mouse	S1113	PHOSPHORYLATION	456507	TQTKENEsKA_____		activity, induced				6749	1	0	0	Phosphorylated peptide (but not unphosphorylated form) causes a larger number of transmission failures and acts as a dominant negative to the protein (similar to the null).  This region of NCAM1 appears to signal through the MLCK-MLC pathway (induces MLC phosphorylation) in a putative myosin II-mediated process.	
PARVA	Adaptor/scaffold; Motility/polarity/chemotaxis	Q9NVD7	55742	PARVA	11p15.3	human	S4	PHOSPHORYLATION	4270096	____MATsPQKSPSV			signaling pathway regulation			26341729	1	3	1	matrix degradation/invasion	
Smad7	DNA binding protein; Transcription factor	O35253	17131	Smad7		mouse	S249	PHOSPHORYLATION	12559510	APGGLSDsQLLLEPG			transcription, induced; transcription, inhibited			12482248	1	0	0	Smad7 activates or inhibits transcription depending on promoter context. S249 phosphorylation is important for both activation and inhibition.	
MUC1	Actin binding protein; Cell adhesion; Membrane protein, integral; Motility/polarity/chemotaxis; Nuclear receptor co-regulator	P15941	4582	MUC1	1q21	human	S1227	PHOSPHORYLATION	455675	PPSSTDRsPYEKVSA		molecular association, regulation		CTNNB1(DISRUPTS)		1349	1	1	11		
NMDAR1	Channel, calcium; Channel, ligand-gated; Membrane protein, integral; Membrane protein, multi-pass	P35439	24408	Grin1		rat	T900	PHOSPHORYLATION	11080321	RRRSSKDtSTGGGRG		activity, inhibited				17675052	1	0	1	phosphomimetic mutations increased sensitivity to inhibition by ethanol	
SIRT1	Apoptosis; DEACETYLASE; Deacetylase; EC 3.5.1.-; Nuclear receptor co-regulator	Q923E4	93759	Sirt1		mouse	S46	PHOSPHORYLATION	452899	DGPGLGRsPGEPSAA		protein degradation; ubiquitination				21387120	3	20	7		
PLSCR3	Membrane protein, integral	Q9NRY6	57048	PLSCR3	17p13.1	human	T21	PHOSPHORYLATION	457790	PPPPYPVtPGYPEPA			apoptosis, induced			7282	1	0	1		
Smad1	DNA binding protein; Transcription factor	Q15797	4086	SMAD1	4q31	human	S195	PHOSPHORYLATION	451174	PNSSYPNsPGSSSST	DUF605	intracellular localization				3385	3	0	0	Erk-mediated phosphorylation inhibits the nuclear accumulation of Smad1.	
CD22 iso4	Cell surface; Membrane protein, integral	Q3U0M3	12483	Cd22		mouse	Y863	PHOSPHORYLATION	450944	QAKEDVDyVTLKH__		molecular association, regulation		SHP-1(INDUCES)		7708800	5	0	12		
DCD	EC 3.4.-.-; Secreted; Secreted, signal peptide	P81605	117159	DCD	12q13.1	human	Y20	PHOSPHORYLATION	18752500	AGALVCAyDPEAASA		molecular association, regulation	cell motility, altered	Nck1(INDUCES)		18751204	1	0	0		
NFkB-p105	DNA binding protein; Transcription factor	P19838	4790	NFKB1	4q24	human	S923	PHOSPHORYLATION	447769	DELRDSDsVCDSGVE		protein degradation				1189	2	0	2		
GluR1	Channel, calcium; Channel, ligand-gated; Membrane protein, integral; Membrane protein, multi-pass	P23818	14799	Gria1		mouse	S849	PHOSPHORYLATION	448565	FCLIPQQsINEAIRT		activity, induced; receptor desensitization, altered; intracellular localization; receptor internalization, altered; receptor recycling, altered				1163201; 3394323; 1985; 21356313; 2705203; 3361001; 4317104	64	2	3	channel conductance; Phosphorylation sites required for synaptic plasticity.; promotes conditioned reinforcement; S849 ; synaptic plasticity;  Norepinephrine faciitates synaptic delivery of GLuR1 receptors, LTP, and emotion enhanced learning though phosphorylation of GLuR1. ;  associative LTD requires phosphorylation of both S863 and S849.; Associative LTP requires S863 phosphorylation	
SIAH2	EC 6.3.2.-; EC 6.3.2.19; Ligase; Transcription, coactivator/corepressor; UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase	Q06986	20439	Siah2		mouse	S29	PHOSPHORYLATION	471339	PQTPHAPsPAAPPAA		molecular association, regulation; intracellular localization		EGLN3(INDUCES)		9114	5	1	0	plays a role in degradation of endogenous EGLN3 (PHD3).	
DYN2	EC 3.6.5.5; Hydrolase; Microtubule binding protein; Motility/polarity/chemotaxis; Vesicle protein	P50570	1785	DNM2	19p13.2	human	S764	PHOSPHORYLATION	3191449	LQSASSHsPTPQRRP		molecular association, regulation; intracellular localization	cell cycle regulation			15562515; 17675056	3	6	0	important for cytokinesis; reduces microtubule-binding activity of DYN2 	
EFNB2	Ligand, receptor tyrosine kinase; Membrane protein, integral	P52799	1948	EFNB2	13q33	human	Y304	PHOSPHORYLATION	451679	DSVFCPHyEKVSGDY	Shisa	molecular association, regulation; protein conformation		Nck2(INDUCES)		3784	0	15	208	Y304 phosphopeptide can also bind (simultaneously) to PDZ domain of RGS3;  not phosphorylation-dependent	
SP1	C2H2-type zinc finger protein; DNA binding protein; Transcription factor	P08047	6667	SP1	12q13.1	human	T278	PHOSPHORYLATION	1988302	SVSAATLtPSSQAVT		protein stabilization	cell cycle regulation; transcription, induced			1968333; 6829240	2	0	0	 regulates cell proliferation; protects from ubiquitin-dependent degradation during mitosis; during mitosis	
SKAP55	Adaptor/scaffold; Motility/polarity/chemotaxis	Q86WV1	8631	SKAP1	17q21.32	human	Y232	PHOSPHORYLATION	451308	EEEKEETyDDIDGFD		molecular association, regulation; intracellular localization; phosphorylation	transcription, induced	CD45(INDUCES)		3533	1	0	1		
MEKK3	EC 2.7.11.25; KINASE; Kinase, protein; Protein kinase, STE; Protein kinase, Ser/Thr (non-receptor)	Q99759	4215	MAP3K3	17q23.3	human	T516	PHOSPHORYLATION	12607405	GASKRLQtICMSGTG	Pkinase	enzymatic activity, induced				12525215	2	0	0	essential for MEKK3-mediated IKK-beta/NFkB activation	
Lmr1 iso2	EC 2.7.11.1; KINASE; Kinase, protein; Membrane protein, integral; Protein kinase, TK; Protein kinase, tyrosine (receptor)	Q80YE4-2	11302	Aatk		mouse	S34	PHOSPHORYLATION	14364500	ADFSEQGsPAAAAQT		intracellular localization; phosphorylation				14790304; 14058619	3	0	0	influences transferrin uptake and recycling; inhibits tyrosine phosphorylation of Lmr1	
IL16	Cytokine; DNA binding protein; Motility/polarity/chemotaxis	Q14005	3603	IL16	15q26.3	human	S743	PHOSPHORYLATION	11280302	MPLQPNAsLNEEEGT		intracellular localization	cell cycle regulation			10303908	1	0	0	regulate nuclear localization	
FOXO1A	DNA binding protein; Nuclear receptor co-regulator; Transcription factor	Q12778	2308	FOXO1	13q14.1	human	S249	PHOSPHORYLATION	471071	EGGKSGKsPRRRAAS	Fork_head	molecular association, regulation; intracellular localization; activity, inhibited	cell cycle regulation; apoptosis, induced; apoptosis, inhibited; transcription, induced; transcription, inhibited; transcription, altered	14-3-3 beta(INDUCES)		4207611; 4254813; 9027; 27619361	10	0	2		
NFkB-p65	DNA binding protein; Nuclear receptor co-regulator; Transcription factor	Q04206	5970	RELA	11q13	human	T435	PHOSPHORYLATION	451422	PTQAGEGtLSEALLQ			transcription, inhibited			12662607	2	0	0		
SLC4A1	Membrane protein, integral; Membrane protein, multi-pass; Transporter	P02730	6521	SLC4A1	17q21.31	human	Y21	PHOSPHORYLATION	457533	ENLEQEEyEDPDIPE		molecular association, regulation		Lyn(INDUCES)		8343	4	2	0	Y8 and/or Y21.	
MARK3 iso3	EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, CAMK; Protein kinase, Ser/Thr (non-receptor)	P27448-3	4140	MARK3	14q32.3	human	T95	PHOSPHORYLATION	3597305	DKTQLNPtSLQKLFR	Pkinase	enzymatic activity, inhibited				8987	1	0	0		
FAK	EC 2.7.1.112; EC 2.7.10.2; KINASE; Kinase, protein; Protein kinase, TK; Protein kinase, tyrosine (non-receptor)	O35346	25614	Ptk2		rat	S913	PHOSPHORYLATION	447964	RLQPQEIsPPPTANL		molecular association, regulation; intracellular localization				2255; 7379	16	26	0		
NFAT2	DNA binding protein; Transcription factor	O95644	4772	NFATC1	18q23	human	S187	PHOSPHORYLATION	465578	RSCNSEAsSYESNYS		intracellular localization				8031	1	0	1	cooperates with S172 to induce nuclear localization of NFAT2	
VASP	Cytoskeletal protein; Motility/polarity/chemotaxis	P50552	7408	VASP	19q13.32	human	T278	PHOSPHORYLATION	448381	LARRRKAtQVGEKTP			carcinogenesis, altered; cell motility, altered; cytoskeletal reorganization; transcription, inhibited			18668225; 9086; 5358615; 3413	9	3	19		
MOR-1	GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR	P33535	25601	Oprm1		rat	T394	PHOSPHORYLATION	448128	LENLEAEtAPLP___		receptor desensitization, altered; receptor internalization, altered				2927; 8655; 1680	4	0	0	in vitro adenylyl cyclase inhibition ; truncation that deletes T370, S375 and T394 alters kinetics of receptor internalization and desensitization	
IRS1	Adaptor/scaffold; Motility/polarity/chemotaxis	P35568	3667	IRS1	2q36	human	Y612	PHOSPHORYLATION	447555	TLHTDDGyMPMSPGV		molecular association, regulation		PIK3R1(INDUCES)		1140	17	7	298		
PTHrP	Secreted; Secreted, signal peptide	P12272	5744	PTHLH	12p12.1-p11.2	human	T121	PHOSPHORYLATION	449879	YKEQPLKtPGKKKKG	Parathyroid; Herpes_DNAp_acc	molecular association, regulation; intracellular localization		KPNB1(DISRUPTS)		2428; 10144209	1	0	0	decreases nuclear accumulation; T121E mutation was localized in the cytoplasm, while a T121A mutation showed nuclear localization.	
Kv11.1	Channel, potassium; Membrane protein, integral; Membrane protein, multi-pass; Motility/polarity/chemotaxis	Q12809	3757	KCNH2	7q36.1	human	S890	PHOSPHORYLATION	3893409	RQRKRKLsFRRRTDK		activity, induced; protein stabilization; intracellular localization; activity, inhibited				25347058; 10292905	4	1	3	rapid reduction in channel current; regulates membrane localization of the channel and contributes to its stability	
IHPK2	EC 2.7.4.21; Kinase, other; Motility/polarity/chemotaxis	Q9UHH9	51447	IP6K2	3p21.31	human	S356	PHOSPHORYLATION	18258507	AEDLEDLsEESADES	IPK	protein degradation; ubiquitination				18021026	1	1	0		
IKK-gamma	Adaptor/scaffold; Protein kinase, regulatory subunit	O88522	16151	Ikbkg		mouse	S375	PHOSPHORYLATION	449755	HSFHLALsNQRRSPP		activity, inhibited	transcription, altered			1957	1	0	0	NFKB reporter assays	
PTP1B	EC 3.1.3.48; Motility/polarity/chemotaxis; PHOSPHATASE; Phosphatase; Protein phosphatase, tyrosine (non-receptor)	P18031	5770	PTPN1	20q13.1-q13.2	human	Y152	PHOSPHORYLATION	449312	ISEDIKSyYTVRQLE	Y_phosphatase	molecular association, regulation		InsR(INDUCES)		2178	4	0	1		
RPS3	Apoptosis; Ribosomal protein; Translation	P23396	6188	RPS3	11q13.3-q13.5	human	S6	PHOSPHORYLATION	8046503	__MAVQIsKKRKFVA		activity, induced; intracellular localization	translation, altered			8049907	2	0	0	important for a cell survival in the stress condition	
Snail1	C2H2-type zinc finger protein; Transcription factor	O95863	6615	SNAI1	20q13.2	human	S112	O-GlcNAc	18416103	PPSPAPSsFSSTSVS	CAP_N	protein stabilization; phosphorylation	cell motility, induced; transcription, inhibited			15755116	1	1	0	 transcriptional suppression of E-cadherin; inhibits O-phosphorylation;  induces cell migration and in vivo invasion	
TTK	Cancer Testis Antigen (CTA); EC 2.7.12.1; KINASE; Kinase, protein; Protein kinase, Other; Protein kinase, dual-specificity	P33981	7272	TTK	6q13-q21	human	T288	PHOSPHORYLATION	6370307	SPDCDVKtDDSVVPC		protein stabilization	cell cycle regulation			6331327	2	1	0		
AT1	GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR	P25095	24180	Agtr1		rat	Y319	PHOSPHORYLATION	448745	YFLQLLKyIPPKAKS		activity, induced; molecular association, regulation		EGFR(INDUCES)		1914	5	0	0	AT1-EGFR interaction is inhibited by dominant negative SHP-2. Y319 phosphorylation increased angiotensin II induced proliferation. 	
FRS2	Adaptor/scaffold	Q8C180	327826	Frs2		mouse	Y436	PHOSPHORYLATION	448154	LEHRQLNyIQVDLEG		molecular association, regulation		SHP-2(INDUCES)		1357	1	0	0		
AATF	Transcription factor	Q9NY61	26574	AATF	17q12	human	S510	PHOSPHORYLATION	3753302	KKVDRKAsKGRKLRF	TRAUB	protein stabilization; molecular association, regulation	apoptosis, inhibited; transcription, altered	NFkB-p65(INDUCES)	DNA(INDUCES)	9225	1	0	0		
emerin	Cytoskeletal protein; Membrane protein, integral	P50402	2010	EMD	Xq28	human	Y19	PHOSPHORYLATION	10897601	LTTLLRRyNIPHGPV	LEM	molecular association, regulation		BAF(INDUCES)		10425105	1	1	0		
IKKB	EC 2.7.11.10; KINASE; Kinase, protein; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor)	O88351	16150	Ikbkb		mouse	S181	PHOSPHORYLATION	447489	DQGSLCTsFVGTLQY	Pkinase	molecular association, regulation; enzymatic activity, induced; phosphorylation	apoptosis, altered; cell differentiation, induced	PPP2R3C(INDUCES)		6782009; 22881913; 17675011	50	0	0	interaction with PPP2R3C (aka G4-1) downregulates IKK-beta activity;  S181 phosphorylation increased in S679/682/689/692/697/701/705A mutant; IKK-alpha/beta are effectors of B-Raf mediated survival. ; osteoclast differentiation	
TRHR	GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR	Q01717	25570	Trhr		rat	S360	PHOSPHORYLATION	1229701	NYSVIKEsDRFSTEL		receptor internalization, altered				1172827; 14551416	3	0	0		
PARP10	EC 2.4.2.30; Transferase	Q53GL7	84875	PARP10	8q24.3	human	T101	PHOSPHORYLATION	12526705	QGLPPGTtPQRLEQH		molecular association, regulation; intracellular localization	transcription, altered; cell growth, altered	POLR2A(INDUCES)		12482270	1	0	0	PARP10 T101 phosphorylation is associated with actively growing cells.	
SHP-1	EC 3.1.3.48; Motility/polarity/chemotaxis; PHOSPHATASE; Protein phosphatase, tyrosine (non-receptor)	P29350	5777	PTPN6	12p13	human	Y564	PHOSPHORYLATION	448912	SKHKEDVyENLHTKN		molecular association, regulation; enzymatic activity, induced		SH3BP2(INDUCES); PIK3R1(INDUCES); Grb2(INDUCES)		3353; 7997; 4005; 2421	5	8	740	3BP2 is a potential substrate for SHP-1	
IGFBP3	Cell development/differentiation; Secreted; Secreted, signal peptide	P17936	3486	IGFBP3	7p13-p12	human	S183	PHOSPHORYLATION	471397	KKGHAKDsQRYKVDY		intracellular localization	apoptosis, altered; cell growth, induced; apoptosis, inhibited			27902301; 9087	2	0	0		
NIFK	RNA binding protein	Q9BYG3	84365	MKI67IP	2q14.3	human	T238	PHOSPHORYLATION	449333	QGPTPVCtPTFLERR	hNIFK_binding	molecular association, regulation		KI-67(INDUCES)		2194	1	12	64		
SP1	C2H2-type zinc finger protein; DNA binding protein; Transcription factor	P08047	6667	SP1	12q13.1	human	S59	PHOSPHORYLATION	452233	GGQESQPsPLALLAA		O-GlcNAc glycosylation; protein degradation	transcription, inhibited; transcription, altered			8939; 7313805; 17431529; 2425224	4	6	0	 negatively controls SP1 glycosylation; regulates cellular senescence; decreases SP1 association with chromatin; increased PPP2CA amounts in SLE T cells mediate S59-dephosphorylation and functional activation of SP1	
PGC-1 alpha	Nuclear receptor co-regulator; Transcription, coactivator/corepressor	Q9UBK2	10891	PPARGC1A	4p15.1	human	T263	PHOSPHORYLATION	448241	TTLSLPLtPESPNDP		protein stabilization				1382	2	0	0		
HDAC6	Deacetylase; EC 3.5.1.98; Ubiquitin conjugating system	XP_228753	84581	Hdac6		rat	S21	PHOSPHORYLATION	453006	KSRHNPQsPLQDSSA		enzymatic activity, induced				14743114	1	16	17		
MST1	Autophagy; EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, STE; Protein kinase, Ser/Thr (non-receptor)	Q13043	6789	STK4	20q11.2-q13.2	human	T120	PHOSPHORYLATION	11496001	IIRLRNKtLTEDEIA	Pkinase	intracellular localization; enzymatic activity, inhibited; phosphorylation	apoptosis, altered			11419366	2	0	0	regulates autophosphorylation of MST1 T183	
FOXO4	DNA binding protein; Transcription factor	P98177	4303	FOXO4	Xq13.1	human	S262	PHOSPHORYLATION	448517	TFRPRSSsNASSVST		intracellular localization	transcription, inhibited			448; 447	3	0	2		
PTHR	GPCR, family 2; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR	P25961	56813	Pth1r		rat	S493	PHOSPHORYLATION	2853105	KARSGSSsYSYGPMV		receptor internalization, altered; activity, inhibited				8759; 2831777	2	0	0		
IGFBP3	Cell development/differentiation; Secreted; Secreted, signal peptide	P17936	3486	IGFBP3	7p13-p12	human	S194	PHOSPHORYLATION	10902818	KVDYESQsTDTQNFS		phosphorylation	apoptosis, altered			10425110	1	0	0	inhibits JNK phosphorylation and apoptosis	
NUP98 iso2	Motility/polarity/chemotaxis; Nucleoporin	P52948-2	4928	NUP98	11p15.5	human	S568	PHOSPHORYLATION	18330802	GLDDDEPsLANGAFM		intracellular localization				18331300	1	1	0	as multiple sites (13PM) mutant 	
Vax2	DNA binding protein; Transcription factor	Q9WTP9	24113	Vax2		mouse	S170	PHOSPHORYLATION	470130	RDLEKRAsSSASEAF		intracellular localization				8997	1	0	0	causes relocalization of Vax2 to cytoplasm;  controls eye developement in mice	
TXA2-R iso2	GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR	P21731-2	6915	TBXA2R	19p13.3	human	T332	PHOSPHORYLATION	18790000	TRPRRSLtLWPSLEY		receptor desensitization, altered				8851	1	0	0		
NPY1R	GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR	P21555	29358	Npy1r		rat	T353	PHOSPHORYLATION	2815304	YETIAMStMHTDVSK		receptor desensitization, altered; receptor internalization, altered				4358	1	0	1	may be an artifact of the truncation mutants	
Tip60	ACETYLTRANSFERASE; Acetyltransferase; EC 2.3.1.-; EC 2.3.1.48; Nuclear receptor co-regulator	Q92993	10524	KAT5	11q13	human	S86	PHOSPHORYLATION	448826	TKNGLPGsRPGSPER		acetylation; protein stabilization	apoptosis, induced; transcription, induced; transcription, altered			7029; 21655807	4	13	3	APP-dependent transactivation and stabilization.; acetylation of p53 K120 and induction of PUMA	
PCGF1	EC 6.3.2.-; Ligase; UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase	Q9BSM1	84759	PCGF1	2p13.1	human	S195	PHOSPHORYLATION	2897400	QNKYVRCsVRAEVRH	Rad60-SLD		transcription, inhibited			8691	1	0	0		
STIM1	Calcium-binding protein; Endoplasmic reticulum; Membrane protein, integral	Q13586	6786	STIM1	11p15.5	human	S575	PHOSPHORYLATION	468876	LVEKLPDsPALAKKA		molecular association, regulation		CDON(INDUCES)		23260309	5	32	12	promotes myoblast differentiation	
Myc	DNA binding protein; Transcription factor	P01106	4609	MYC	8q24.21	human	Y74	PHOSPHORYLATION	17553985	SGLCSPSyVAVTPFS	Myc_N	intracellular localization	cell growth, induced			27519641	1	1	0	pY74 is localized to the cytoplasm, and is critical for maximal Myc activity in cellular transformation.	
TRPC6	Channel, cation; Membrane protein, integral; Membrane protein, multi-pass	Q9Y210	7225	TRPC6	11q22.1	human	T70	PHOSPHORYLATION	470868	RLAHRRQtVLREKGR		activity, inhibited				12028111	9	2	6	suppresses TRPC6 channel current, G-alpha agonist-induced NFAT activation and myocyte hypertrophic responses	
POLH	DNA repair; EC 2.7.7.7; Transferase	Q9Y253	5429	POLH	6p21.1	human	T617	PHOSPHORYLATION	5024700	SKSVLEVtQKATPNP	PRP21_like_P	intracellular localization	cell growth, altered			5007913	1	0	0	foci formation efficiency after  DNA damage	
NDFIP2	Adaptor/scaffold; Membrane protein, integral; Membrane protein, multi-pass	Q9NV92	54602	NDFIP2	13q31.1	human	Y186	PHOSPHORYLATION	15229533	VATSLPTyDEAEKAK	DUF2370	phosphorylation				25779412	1	0	3	Y167, Y177 and Y186 phosphorylation are dependent on Y171 phosphorylation.	
JunD	Motility/polarity/chemotaxis; Transcription factor	P17535	3727	JUND	19p13.2	human	S100	PHOSPHORYLATION	456168	LGLLKLAsPELERLI	Jun		transcription, induced	MEN1(DISRUPTS)		25608308	5	31	12	Menin-JunD interaction blocks JNK mediated JunD phosphorylation, suppressing JunD induced transcription. 	
FOXA2	DNA binding protein; Transcription factor	Q9Y261	3170	FOXA2	20p11	human	S107	PHOSPHORYLATION	22825100	AGMGPHLsPSLSPLG	Fork_head_N		carcinogenesis, induced; cell growth, induced; transcription, inhibited; signaling pathway regulation			22723910	1	1	0		
FLT3	EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Protein kinase, TK; Protein kinase, tyrosine (receptor)	P36888	2322	FLT3	13q12	human	Y591	PHOSPHORYLATION	448190	SSDNEYFyVDFREYE		enzymatic activity, induced; phosphorylation	cell growth, altered			1992301; 6759; 2594	12	0	0	The double mutation Y589/591F has a slower growth rate (this is in the ligand-independent, constitutive active allele).; While none of the single mutations affected STAT-5 phosphotyrosine levels, 3 double mutations did:  Y591/726F, Y591/955F, Y589/591F (all three pairs have Y591F in common).	
caveolin-2	Adaptor/scaffold; Motility/polarity/chemotaxis	NP_571989	363425	Cav2		rat	Y19	PHOSPHORYLATION	450198	LFMADDAySHHSVVD	Caveolin	molecular association, regulation; intracellular localization; phosphorylation	cell cycle regulation	ERK2(INDUCES); ERK1(INDUCES)		9985928; 7910522	8	7	23	in response to insulin; stimulates phosphorylation of ERK1 T203/Y205 and  ERK2 T183/Y185	
KATNA1	EC 3.6.4.3; Hydrolase; Motility/polarity/chemotaxis	O75449	11104	KATNA1	6q25.1	human	S42	PHOSPHORYLATION	26401200	QMNKYLYsVKDTYLQ		ubiquitination	cell cycle regulation			25779408	1	0	0		
MC2R	GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR	Q64326	17200	Mc2r		mouse	S208	PHOSPHORYLATION	456021	RSHARKIsTLPRTNM	7tm_1	receptor desensitization, altered				6572	1	0	0		
GLP1R	GPCR, family 2; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR	P32301	25051	Glp1r		rat	S432	PHOSPHORYLATION	451367	LNIQRDSsMKPLKCP		receptor desensitization, altered				3574	1	0	0		
EB3	Microtubule binding protein	Q9UPY8	22924	MAPRE3	2p23.3-p23.1	human	S162	PHOSPHORYLATION	2023813	TAVPQRTsPTGPKNM		molecular association, regulation; protein conformation	cell adhesion, induced; cytoskeletal reorganization	PPP3CA(DISRUPTS)		27257035	1	11	1	 inhibits persistent microtubule growth and supports adherens junctions integrity;  destabilizes EB3 dimers	
APC	Motility/polarity/chemotaxis; Tumor suppressor	P25054	324	APC	5q21-q22	human	S1507	PHOSPHORYLATION	452097	FSCSSSLsALSLDEP	APC_crr	molecular association, regulation; phosphorylation		CTNNB1(INDUCES)		970021; 4038	1	0	0	primes for phosphorylation of S1510 and S1507,  by CK1 and GSK3B respectively; based on acidic phospho-mimetic mutant	
DCC	Immunoglobulin superfamily; Membrane protein, integral; Receptor, misc.	Q63155	25311	Dcc		rat	Y1418	PHOSPHORYLATION	454409	TEDPASVyEQDDLSE	Neogenin_C		cell growth, altered			1968361; 4277	2	0	0		
NHE3	Membrane protein, integral; Membrane protein, multi-pass; Transporter	P26432	100009430	NHE-3		rabbit	S719	PHOSPHORYLATION	3496800	KERELELsDPEEAPD		activity, induced; intracellular localization				3301204	2	1	0		
GR	DNA binding protein; Mitochondrial; Nuclear receptor; Transcription factor	P06536	24413	Nr3c1		rat	S246	PHOSPHORYLATION	451796	LIDENLLsPLAGEDD	GCR	activity, induced; activity, inhibited	transcription, induced; transcription, altered			5948; 4234; 2406554; 3951; 1968367	23	4	1	modulates sumoylation at K297 and K313; induces hormone-dependent recruitment of GR to promoters (of tat, sult and gliz genes)	
p63	DNA binding protein; Transcription factor	Q9H3D4	8626	TP63	3q28	human	S43	PHOSPHORYLATION	27937107	YRSTMSQsTQTNEFL		molecular association, regulation	transcription, inhibited	p300(DISRUPTS)		27902339	1	1	0		
DVL2	Adaptor/scaffold; Motility/polarity/chemotaxis	O14641	1856	DVL2	17p13.1	human	T595	PHOSPHORYLATION	27623903	GSRSSGStRSDGGAG	Dsh_C		cytoskeletal reorganization; transcription, inhibited			27619331	1	0	0	neurite outgrowth	
AurA	EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor)	P97477	20878	Aurka		mouse	T279	PHOSPHORYLATION	448784	APSSRRTtMCGTLDY	Pkinase	intracellular localization; enzymatic activity, induced				6011107	26	4	7	AurA activation in early meiosis	
gephyrin	Adaptor/scaffold; EC 2.10.1.1; EC 2.7.7.75	Q8BUV3	268566	Gphn		mouse	S194	PHOSPHORYLATION	478375	PSPPPPLsPPPTTSP		molecular association, regulation		Pin1(INDUCES)		9631	3	21	0		
HP1 alpha	Transcription, coactivator/corepressor	Q61686	12419	Cbx5		mouse	S11	PHOSPHORYLATION	476162	KTKRTADsSSSEDEE		molecular association, regulation		H3(INDUCES)	DNA(INDUCES)	18021019	1	17	2	important for chromosomal stability	
FOXG1	DNA binding protein; Transcription factor	Q60987	15228	Foxg1		mouse	T271	PHOSPHORYLATION	482881	KLRRRSTtSRAKLAF			apoptosis, altered			19016940	2	0	0	promotes cell survival	
Ig-alpha	Immunoglobulin superfamily; Membrane protein, integral	P11911	12518	Cd79a		mouse	Y176	PHOSPHORYLATION	447751	GVDMPDDyEDENLYE		molecular association, regulation; intracellular localization		BLNK(INDUCES); VAV1(INDUCES); Grb2(INDUCES)		3517	5	2	4		
Bcl-10	Apoptosis; Transcription, coactivator/corepressor	O95999	8915	BCL10	1p22	human	S138	PHOSPHORYLATION	470125	NNLSRSNsDESNFSE		phosphorylation	cell motility, altered; cytoskeletal reorganization; transcription, altered			11461; 14562608	7	11	18		
AML2	DNA binding protein; Transcription factor	Q13761	864	RUNX3	1p36	human	T155	PHOSPHORYLATION	6097703	KSFTLTItVFTNPTQ	Runt	protein stabilization; intracellular localization	cell cycle regulation; transcription, altered			6095014	1	1	0		
RCC1	Guanine nucleotide exchange factor, Ras	P18754	1104	RCC1	1p36.1	human	S29	PHOSPHORYLATION	2850004	KVKVSHRsHSTEPGL		molecular association, regulation		KPNA4(DISRUPTS)		2831773	1	0	0		
PPP1R2	Inhibitor protein; Motility/polarity/chemotaxis; Protein phosphatase, regulatory subunit	P41236	5504	PPP1R2	3q29	human	S44	PHOSPHORYLATION	2231000	DEELSKKsQKWDEMN	IPP-2		cell cycle regulation	PPP1CA(DISRUPTS)		2195703	2	0	0	in response to IR-induced DNA damage	
CFTR	Channel, chloride; EC 3.6.3.49; Hydrolase; Membrane protein, integral; Membrane protein, multi-pass; Transporter	P13569	1080	CFTR	7q31.2	human	T682	PHOSPHORYLATION	2907505	APVSWTEtKKQSFKQ	CFTR_R	activity, induced; activity, inhibited				8384; 8371	2	0	0		
VHL	Tumor suppressor; UBIQUITIN LIGASE; Ubiquitin ligase	P40337	7428	VHL	3p25.3	human	S72	PHOSPHORYLATION	469117	SVNSREPsQVIFCNR	VHL	molecular association, regulation	cytoskeletal reorganization	HIF2A(DISRUPTS)		8267	3	0	0	destabilizes microtubules	
IRF7	DNA binding protein; Transcription factor	Q92985	3665	IRF7	11p15.5	human	S477	PHOSPHORYLATION	1276101	VSSLDSSsLSLCLSS		intracellular localization	transcription, induced			8586	4	0	0		
TRF1	DNA binding protein	P54274	7013	TERF1	8q21.11	human	T371	PHOSPHORYLATION	3727647	VSKSQPVtPEKHRAR		phosphorylation				3301227	3	2	5	stimulates phosphorylation of residue S435	
PDX1	DNA binding protein; Transcription factor	P52945	3651	PDX1	13q12.1	human	S66	PHOSPHORYLATION	458402	QGSPPDIsPYEVPPL			transcription, induced			8116	3	0	0		
4E-T	Karyopherin; Nuclear import; Translation	Q9NRA8	56478	EIF4ENIF1	22q11.2	human	S693	PHOSPHORYLATION	3213600	ASITSMLsPSFTPTS	EIF4E-T	molecular association, regulation		4E-T(INDUCES)		26341738	1	2	0	required for processing bodies (PBs or P bodies) assembly	
cortactin	Actin binding protein; Cytoskeletal protein; Motility/polarity/chemotaxis	O70420	60465	Cttn		rat	Y428	PHOSPHORYLATION	447703	AYTSEPVyETTEVPG			cell adhesion, altered			8393	16	3	10		
PLSCR1	Calcium-binding protein; Membrane protein, integral	O15162	5359	PLSCR1	3q23	human	Y69	PHOSPHORYLATION	2915403	PVPNQPVyNQPVYNQ		molecular association, regulation		Shc1(INDUCES)		8749	2	0	0		
SPHK2	EC 2.7.1.-; EC 2.7.1.91; Kinase, lipid; Lipid Metabolism - sphingolipid	Q9NRA0	56848	SPHK2	19q13.2	human	S421	PHOSPHORYLATION	486447	SPLHRSVsDLPLPLP		intracellular localization				12166	1	0	0	regulation of nuclear shuttling	
KCNMA1	Channel, potassium; Endoplasmic reticulum; Membrane protein, integral; Membrane protein, multi-pass	Q28204	282573	KCNMA1		cow	S695	PHOSPHORYLATION	456596	DEQPSTLsPKKKQRN		activity, inhibited				14058611	1	11	0		
APP iso4	Apoptosis; Cell surface; Membrane protein, integral; Receptor, misc.; Transcription factor	P05067-4	351	APP	21q21.3	human	Y682	PHOSPHORYLATION	448202	SKMQQNGyENPTYKF	APP_amyloid	molecular association, regulation		Abl iso2(NOT_REPORTED)		916	9	8	836	APP both phosphorylated and not phosphorylated at Y682 interacts with Abl	
phosducin	G protein regulator, misc.	P20942	25343	Pdc		rat	S106	PHOSPHORYLATION	10431701	QDMHQKLsFGPRYGF	Phosducin; SPK; YaaC	molecular association, regulation		GNB1(DISRUPTS); G-gamma(2)(DISRUPTS)		10144212	1	0	0		
DYNC1I1	Microtubule binding protein; Motility/polarity/chemotaxis; Motor protein	Q63100	29564	Dync1i1		rat	S100	PHOSPHORYLATION	6006907	PTPMSPSsKSVSTPS		molecular association, regulation	cytoskeletal reorganization	dynactin 1(DISRUPTS)		6006102; 5930018	2	1	0		
E2A	DNA binding protein; Transcription factor	P15923	6929	TCF3	19p13.3	human	S245	PHOSPHORYLATION	455906	PMLGGGSsPLPLPPG			cell growth, altered			6389	1	0	0		
MFN2	Cell cycle regulation; Cytoskeletal protein; EC 3.6.5.-; Hydrolase; Membrane protein, integral; Membrane protein, multi-pass; Mitochondrial	Q8R500	64476	Mfn2		rat	S442	PHOSPHORYLATION	4746700	AEEIRRLsVLVDEYQ	Apolipoprotein		cell cycle regulation; cell growth, altered			13164209	1	2	0		
GRASP55	Motility/polarity/chemotaxis; Vesicle protein	Q9R064	113961	Gorasp2		rat	S245	PHOSPHORYLATION	12654012	SVSPPSLsPPGTAGV		molecular association, regulation	cytoskeletal reorganization	GRASP55(DISRUPTS)		12576800	1	0	5	inhibits Golgi stack formation in interphase cells and enhances Golgi fragmentation in mitotic cells	
VIPR1	GPCR, family 2; Membrane protein, integral; Membrane protein, multi-pass; Motility/polarity/chemotaxis; Receptor, GPCR	P32241	7433	VIPR1	3p22	human	T429	PHOSPHORYLATION	455876	SGGSNGAtCSTQVSM		receptor desensitization, altered				7761	2	0	0		
p27Kip1	Cell cycle regulation; Inhibitor protein; Protein kinase, regulatory subunit	P46527	1027	CDKN1B	12p13.1-p12	human	T157	PHOSPHORYLATION	448645	GIRKRPAtDDSSTQN		protein degradation; molecular association, regulation; intracellular localization; phosphorylation	cell cycle regulation; apoptosis, inhibited; cytoskeletal reorganization; cell growth, altered	14-3-3 beta(INDUCES); KPNA1(DISRUPTS); 14-3-3 theta(INDUCES); 14-3-3 epsilon(INDUCES); CCND1(INDUCES); 14-3-3 gamma(INDUCES); KPNA5(INDUCES); CDK4(INDUCES)		4324809; 1841; 5459; 3571; 1840; 7124725; 4971001; 1842; 2422200; 2996900; 6011128; 4313620	18	0	1	cytoplasmic localization	
CDK5R1	Protein kinase, regulatory subunit	Q15078	8851	CDK5R1	17q11.2	human	T138	PHOSPHORYLATION	471393	PAVTSAGtPKRVIVQ	CDK5_activator	protein stabilization; activity, inhibited	cytoskeletal reorganization; cell growth, altered			2425232; 9104	6	0	0	inhibits calpain-dependent cleavage of Cdk5R1 (p35 to p25); regulates microtubule-polymerizing and binding activities	
Bcl-xL	Apoptosis; Autophagy; Membrane protein, integral; Mitochondrial	Q07817	598	BCL2L1	20q11.21	human	T115	PHOSPHORYLATION	448162	LTSQLHItPGTAYQS	Bcl-2		apoptosis, induced			928	2	0	0		
Syk	EC 2.7.10.2; KINASE; Kinase, protein; Protein kinase, TK; Protein kinase, tyrosine (non-receptor)	Q64725	25155	Syk		rat	Y317	PHOSPHORYLATION	447658	STVSFNPyEPTGGAW		enzymatic activity, inhibited				17827005; 5410126	14	18	1010		
MST2	Autophagy; EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, STE; Protein kinase, Ser/Thr (non-receptor)	Q13188	6788	STK3	8q22.2	human	T384	PHOSPHORYLATION	3195191	GTMKRNAtSPQVQRP		molecular association, regulation; enzymatic activity, inhibited	apoptosis, altered; signaling pathway regulation	RASSF1(DISRUPTS); MST2(DISRUPTS); RAF1(INDUCES)		12558730	1	3	32		
LIG4	EC 6.5.1.1; Ligase	Q8BTF7	319583	Lig4		mouse	S650	PHOSPHORYLATION	454069	HLKAPNLsNVNKVSN		protein stabilization				4184	1	0	0		
RRAD	G protein; G protein, monomeric, RGK	P55042	6236	RRAD	16q22	human	S214	PHOSPHORYLATION	457394	LVRSREVsVDEGRAC	Ras	molecular association, regulation		calmodulin(INDUCES)		7055	1	0	0		
TRPV6	Channel, calcium; Membrane protein, integral; Membrane protein, multi-pass	Q9H1D0	55503	TRPV6	7q34	human	T702	PHOSPHORYLATION	11381600	WERLRQGtLRRDLRG		molecular association, regulation; activity, inhibited		calmodulin(INDUCES)		10292912	1	0	0	rapid channel inactivation 	
RbBP1	Adaptor/scaffold	P29374	5926	ARID4A	14q23.1	human	S864	PHOSPHORYLATION	14578923	RKILGQSsPEKKIRI		molecular association, regulation		Rb(DISRUPTS)		17675031	1	12	0		
Casp8	Apoptosis; EC 3.4.22.-; EC 3.4.22.61; Protease	Q14790	841	CASP8	2q33-q34	human	Y380	PHOSPHORYLATION	460647	TDSEEQPyLEMDLSS	Peptidase_C14	molecular association, regulation; protein processing; enzymatic activity, inhibited; phosphorylation	apoptosis, altered; apoptosis, induced; cell motility, altered; apoptosis, inhibited; cell adhesion, altered	PIK3R1(INDUCES)		1713146; 7788; 11270027; 5007916; 1713141	6	2	46	; phosphorylation of this site in pro-caspase-8 form supresses protein autocleavage and apoptosis	
TAO1	EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, STE; Protein kinase, Ser/Thr (non-receptor)	Q7L7X3	57551	TAOK1	17q11.2	human	T643	PHOSPHORYLATION	3627518	EELNKRQtQKDLEHA		activity, induced	cell cycle regulation			12287	1	0	0		
IFNAR1	Membrane protein, integral; Receptor, cytokine	P17181	3454	IFNAR1	21q22.11	human	S535	PHOSPHORYLATION	454418	SSQTSQDsGNYSNED		protein degradation; molecular association, regulation		BTRC(NOT_REPORTED)		7775; 4286	7	0	0	IFN alpha -induced degradation of IFNAR1 requires active Tyk2	
ferritin H	Cofactor and Vitamin Metabolism - porphyrin and chlorophyll; EC 1.16.3.1; Oxidoreductase	P02794	2495	FTH1	11q13	human	S179	PHOSPHORYLATION	452608	DKHTLGDsDNES___		molecular association, regulation; intracellular localization; phosphorylation	cell motility, altered	CXCR4(INDUCES)		9026	1	16	4	 overexpression of S178A FHC increases them.  Some S178A FHC is in the nucleus even without CXCL12 treatment, and CXCL12 treatment did not induce further nuclear translocation (as is seen in WT FHC).  Cell motility is effects in chemotaxis in response to CXCL12.; Overexpression of FHC reduces phospho-Erk1/2 levels	
Cdc25C	EC 3.1.3.48; Motility/polarity/chemotaxis; PHOSPHATASE; Protein phosphatase, dual-specificity	P30307	995	CDC25C	5q31	human	S122	PHOSPHORYLATION	449910	DQHLMKCsPAQLLCS	M-inducer_phosp		cell cycle regulation; cell adhesion, altered			2459	1	0	5		
RNF11	EC 6.3.2.-; Ligase; UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase	Q9Y3C5	26994	RNF11	1p32	human	T135	PHOSPHORYLATION	2893400	DWLMRSFtCPSCMEP	zf-RING_2	protein degradation; molecular association, regulation	transcription, altered	14-3-3 gamma(INDUCES)		8776	1	0	0		
XPB	DNA repair; EC 3.6.1.-; EC 3.6.4.12; Helicase; Transcription factor	P19447	2071	ERCC3	2q21	human	S751	PHOSPHORYLATION	454425	FGTMSSMsGADDTVY		activity, inhibited				4288	2	0	0		
FBXW7	Motility/polarity/chemotaxis; UBIQUITIN LIGASE; Ubiquitin conjugating system	Q969H0	55294	FBXW7	4q31.3	human	S349	PHOSPHORYLATION	25126711	IKPGFIHsPWKSAYI		protein degradation	cytoskeletal reorganization			25082807	1	1	0	Phosphorylation prevents ubiquitin-dependent degradation of cyclin E and subsequent centriole duplication.	
CENTD2	GTPase activating protein, ARF; Motility/polarity/chemotaxis	Q96P48-6	116985	ARAP1	11q13.4	human	Y231	PHOSPHORYLATION	3209592	PEFDDSDyDEVPEEG			endocytosis, altered			14780511	1	2	51	inhibits EGFR internalization	
LEPR	Membrane protein, integral; Receptor, cytokine	P48356	16847	Lepr		mouse	Y985	PHOSPHORYLATION	448435	QRQPSVKyATLVSND		activity, induced; molecular association, regulation; activity, inhibited; phosphorylation	transcription, altered	SOCS3(INDUCES); SHP-2(INDUCES)		1621; 3516; 13270514; 8809; 4449; 3515; 1620	14	0	0	attenuation of STAT3 phosphorylation	
FBX5		Q9UKT4	26271	FBXO5	6q25.2	human	Y142	PHOSPHORYLATION	15339200	ALETSRLyEDSGYSS		protein stabilization				15235241	1	0	0		
GK	Carbohydrate Metabolism - amino sugar and nucleotide sugar; Carbohydrate Metabolism - galactose; Carbohydrate Metabolism - glycolysis and gluconeogenesis; Carbohydrate Metabolism - starch and sucrose; EC 2.7.1.2; Kinase, other; Mitochondrial	P35557	2645	GCK	7p15.3-p15.1	human	S411	PHOSPHORYLATION	15426313	ITVGVDGsVYKLHPS	Hexokinase_2	protein conformation; enzymatic activity, induced				18668228	1	0	1		
p53	Activator protein; DNA binding protein; Motility/polarity/chemotaxis; Nuclear receptor co-regulator; Transcription factor; Tumor suppressor	P04637	7157	TP53	17p13.1	human	T18	PHOSPHORYLATION	447541	EPPLSQEtFSDLWKL	P53_TAD	acetylation; protein stabilization; molecular association, regulation	apoptosis, altered; transcription, altered	MDM2(DISRUPTS); p300(INDUCES); CBP(INDUCES)		6461; 1211; 6115915; 5265; 5004513; 5967; 18378508	27	0	0		
GAREM	Adaptor/scaffold	Q9H706	64762	GAREM	18q12.1	human	Y105	PHOSPHORYLATION	9721500	DIKEPVQyFNSVEEV	CABIT	molecular association, regulation		Grb2(INDUCES)		9689401	1	0	0	activates Erk	
RKIP	Inhibitor protein	P31044	29542	Pebp1		rat	S153	PHOSPHORYLATION	448755	RGKFKVEsFRKKYHL	PBP	molecular association, regulation		RAF1(DISRUPTS)		1923	5	8	1	RKIP inhibits MAP kinase activation in response to growth factors or PKC activators, and PKC can regulate Raf-1 signaling through phosphorylation of RKIP. Classical and atypical PKCs phosphorylate RKIP on Ser-153, which results in the displacement of RKIP from Raf-1, freeing Raf-1 to activate downstream targets.. 	
AML1 iso8	DNA binding protein; Transcription factor	Q01196-8	861	RUNX1	21q22.3	human	T300	PHOSPHORYLATION	454403	SPSVHPAtPISPGRA		protein degradation				9029; 6620	6	1	5	Phosphorylation promotes degradation via Cdc20-mediated pathways (Cdh1-mediated regardless of phosphorylation state).	
tau iso8	Cytoskeletal protein	P10636-8	4137	MAPT	17q21.1	human	S396	PHOSPHORYLATION	449081	GAEIVYKsPVVSGDT		O-GlcNAc glycosylation; molecular association, regulation; intracellular localization; protein processing; protein conformation; phosphorylation	cytoskeletal reorganization	TUBA4A(DISRUPTS); TUBA1A(DISRUPTS); TUBB(DISRUPTS); tau iso8(INDUCES)		3475711; 4578; 5955607; 2365406; 8165400; 3579; 2782; 5955603; 6115906; 5955604	96	26	90	The amount of tau in partticulate fraction increased in R406W and V337M mutants compared to WT.; Mutant pseudo-phosphorylation at S396 and S404 or truncation at the C terminus induces tau filament assembly in vitro.	
p53	Activator protein; DNA binding protein; Motility/polarity/chemotaxis; Nuclear receptor co-regulator; Transcription factor; Tumor suppressor	P04637	7157	TP53	17p13.1	human	S376	PHOSPHORYLATION	447570	LKSKKGQsTSRHKKL		activity, induced; protein degradation; molecular association, regulation; intracellular localization; activity, inhibited	cell cycle regulation; chromatin organization, altered; apoptosis, inhibited; transcription, induced	14-3-3 zeta(DISRUPTS); 14-3-3 gamma(INDUCES); BLM(DISRUPTS); 14-3-3 beta(DISRUPTS); WRN(DISRUPTS)	DNA(INDUCES)	7301; 2965; 1209; 7991101; 4798; 3361014; 2948; 5011207	12	0	0	S376/3787 phosphorylated peptides inhibited helicase activityin vitro. S15 phosphorylated p53 colocalized with BLM in vivo.	
p90RSK	EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor); Translation	P18652	386579	RPS6KA1		chicken	S381	PHOSPHORYLATION	447989	TSRTPKDsPGIPPSA	Pkinase_C	intracellular localization; enzymatic activity, induced				6556	36	20	4		
ERK5	EC 2.7.11.24; KINASE; Kinase, protein; Protein kinase, CMGC; Protein kinase, Ser/Thr (non-receptor)	Q13164	5598	MAPK7	17p11.2	human	T219	PHOSPHORYLATION	448205	AEHQYFMtEYVATRW	Pkinase		apoptosis, inhibited			15031301	12	2	33		
KCNMB4	Channel, potassium; Membrane protein, integral; Membrane protein, multi-pass	Q86W47	27345	KCNMB4	12q	human	S210	PHOSPHORYLATION	451270	AMKKRKFs_______		activity, inhibited				3490	1	0	0	regulates slowpoke K(+) channel kinetics	
ER-alpha	DNA binding protein; Nuclear receptor	P03372	2099	ESR1	6q25.1	human	S236	PHOSPHORYLATION	448739	IDKNRRKsCQACRLR	zf-C4		transcription, inhibited			2628	5	1	0		
Casp8	Apoptosis; EC 3.4.22.-; EC 3.4.22.61; Protease	Q14790	841	CASP8	2q33-q34	human	Y448	PHOSPHORYLATION	1032277	TILTEVNyEVSNKDD	Peptidase_C14	enzymatic activity, inhibited	apoptosis, altered			1713141	1	1	0		
HSP27	Chaperone; Motility/polarity/chemotaxis	P14602	15507	Hspb1		mouse	S15	PHOSPHORYLATION	448401	FSLLRSPsWEPFRDW		activity, induced; intracellular localization	apoptosis, induced	PKCD(NOT_REPORTED)		5201	33	40	27		
ELK1	DNA binding protein; Transcription factor	A4GTP4	314436	Elk1		rat	S159	PHOSPHORYLATION	2028400	YMRSGLYsTFTIQSL		activity, inhibited	transcription, inhibited	SRF(DISRUPTS)		1968312	1	0	1		
p53	Activator protein; DNA binding protein; Motility/polarity/chemotaxis; Nuclear receptor co-regulator; Transcription factor; Tumor suppressor	P02340	22059	Tp53		mouse	S386	PHOSPHORYLATION	447535	VKKVGPDsD______		activity, induced	cell cycle regulation; apoptosis, altered; apoptosis, induced; transcription, induced; transcription, altered; cell growth, altered		DNA(INDUCES)	4214802; 7309830; 6115922; 5010610; 5259; 4168	87	6	0	induced by cyclin E oveerexpression in high density  cells; in response to pX; tumorigenesis	
ARHGAP24	GTPase activating protein, Rac/Rho; Motility/polarity/chemotaxis	Q8N264	83478	ARHGAP24	4q22.1	human	T452	PHOSPHORYLATION	12518705	GLEKTQTtPNGSLQA		activity, induced	cytoskeletal reorganization			12482285	1	1	2	membrane blebbing	
PIKFYVE	Carbohydrate Metabolism - inositol phosphate; EC 2.7.1.150; EC 2.7.1.68; Kinase, lipid; Motility/polarity/chemotaxis	Q9Z1T6	18711	Pikfyve		mouse	S307	PHOSPHORYLATION	457532	PARNRSAsITNLSLD		intracellular localization				28722420	3	25	133	recruitment to vesicles to catalyse PtdIns(3,5)P2 production	
Syk	EC 2.7.10.2; KINASE; Kinase, protein; Protein kinase, TK; Protein kinase, tyrosine (non-receptor)	P48025	20963	Syk		mouse	Y290	PHOSPHORYLATION	448709	IISRIKSySFPKPGH		intracellular localization				15755119	2	5	106		
IRAK1	EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, Ser/Thr (non-receptor); Protein kinase, TKL	P51617	3654	IRAK1	Xq28	human	T66	PHOSPHORYLATION	447722	CERSGQRtASVLWPW	RAMP; Death	protein conformation				2831763	3	0	0		
RARA	DNA binding protein; Nuclear receptor; Transcription factor	P11416	19401	Rara		mouse	S77	PHOSPHORYLATION	455459	EIVPSPPsPPPLPRI		activity, induced	transcription, altered			12660608	8	0	0		
profilin 1	Actin binding protein; Cytoskeletal protein; Motility/polarity/chemotaxis	P07737	5216	PFN1	17p13.3	human	S138	PHOSPHORYLATION	2850008	MASHLRRsQY_____		molecular association, regulation; activity, inhibited		ACTA1(DISRUPTS); Huntingtin(DISRUPTS)		2831751	5	0	0		
SRC-1	ACETYLTRANSFERASE; Acetyltransferase; DNA binding protein; EC 2.3.1.48; Nuclear receptor co-regulator; Transcription, coactivator/corepressor	Q15788	8648	NCOA1	2p23	human	S1185	PHOSPHORYLATION	449064	GTPPASTsPFSQLAA	DUF1518		transcription, altered			5309423; 2104	4	0	0	activates cPR A form receptor	
FcRL3	Adaptor/scaffold; Membrane protein, integral	Q96P31	115352	FCRL3	1q21-q22	human	Y692	PHOSPHORYLATION	469982	HEELTVLySELKKTH		molecular association, regulation		SHP-1(INDUCES)		8823	1	0	0		
PDE4D iso6	EC 3.1.4.17; Nucleotide Metabolism - purine; Phosphodiesterase	Q08499-6	5144	PDE4D	5q12	human	S126	PHOSPHORYLATION	458388	VHSQRREsFLYRSDS		enzymatic activity, induced				28722189	8	9	0		
PML	Transcription factor; Tumor suppressor; Ubiquitin conjugating system	P29590	5371	PML	15q22	human	S8	PHOSPHORYLATION	470923	MEPAPARsPRPQQDP		sumoylation	apoptosis, altered			5354446	1	18	1	induces sumoylation	
MDC1	Cell cycle regulation	Q14676	9656	MDC1	6p21.3	human	T331	PHOSPHORYLATION	477988	FGFIDSDtDAEEERI		molecular association, regulation	cell cycle regulation	NBS1(INDUCES)		4042508	1	12	25	MDC1-NBS1 interaction regulates intra-S-phase checkpoint activation	
FOXO1A	DNA binding protein; Nuclear receptor co-regulator; Transcription factor	Q12778	2308	FOXO1	13q14.1	human	S383	PHOSPHORYLATION	12607402	DNLNLLSsPTSLTVS		intracellular localization	transcription, altered			12525214	1	0	0	multiple site mutant (8A)	
HEC1	Cell cycle regulation	O14777	10403	NDC80	18p11.32	human	S44	PHOSPHORYLATION	474539	KPTFGKLsINKPTSE			cell cycle regulation			9229	1	0	0	mutation of six N-terminal residues (S5,S15,S44,T49,S55 and S69) to alanines interferes with mitosis	
CD22	Cell surface; Membrane protein, integral	P35329	12483	Cd22		mouse	Y837	PHOSPHORYLATION	456699	PEDESIHySELVQFG		molecular association, regulation; phosphorylation		SHP-1(INDUCES)		1172849	4	0	5		
YAP1 iso2	Transcription, coactivator/corepressor	P46937-2	10413	YAP1	11q13	human	S94	PHOSPHORYLATION	3253276	RLRKLPDsFFKPPEP	FAM181		transcription, induced			7124733	2	0	3		
Kv3.4	Channel, potassium; Membrane protein, integral; Membrane protein, multi-pass	Q03721	3749	KCNC4	1p21	human	S21	PHOSPHORYLATION	451078	KSGNKPPsKTCLKEE	Potassium_chann	receptor inactivation, altered; protein conformation; activity, inhibited				13251000; 3296	2	1	0		
PKCD	EC 2.7.10.2; EC 2.7.11.13; KINASE; Kinase, protein; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor)	P28867	18753	Prkcd		mouse	Y187	PHOSPHORYLATION	447579	WGLNKQGyKCRQCNA	DUF4206; C1_1; Prok-RING_1; PHD	molecular association, regulation; intracellular localization	apoptosis, induced; transcription, altered	Fyn(INDUCES)		3434; 1243	6	0	0		
NPY1R	GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR	P21555	29358	Npy1r		rat	S362	PHOSPHORYLATION	2815303	HTDVSKTsLKQASPV		receptor internalization, altered				4358	1	0	0	may be an artifact of the truncation mutants	
EphB3	EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Protein kinase, TK; Protein kinase, tyrosine (receptor)	P54753	2049	EPHB3	3q21-qter	human	Y614	PHOSPHORYLATION	448275	VYIDPFTyEDPNEAV		molecular association, regulation		RASA1(INDUCES); Crk(INDUCES); Fyn(INDUCES)		1650	1	20	205		
AQP2	Channel, misc.; Membrane protein, integral; Membrane protein, multi-pass	P41181	359	AQP2	12q12-q13	human	S256	PHOSPHORYLATION	449854	REVRRRQsVELHSPQ		molecular association, regulation; intracellular localization		TIRAP(INDUCES); AQP2(INDUCES)		7285; 8341; 1172863; 8854; 3224; 3225; 970049; 4641407; 5796; 5831	48	7	0		
MELK	EC 2.7.10.2; EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, CAMK; Protein kinase, Ser/Thr (non-receptor); RNA splicing	Q14680	9833	MELK	9p13.2	human	S171	PHOSPHORYLATION	2861400	HLQTCCGsLAYAAPE	Pkinase	enzymatic activity, induced				2852669	1	0	0		
Pin1	EC 5.2.1.8; Isomerase; Nuclear receptor co-regulator	Q13526	5300	PIN1	19p13	human	S138	PHOSPHORYLATION	25519816	QKPFEDAsFALRTGE	Rotamase	intracellular localization	cell cycle regulation			25347021	1	1	0		
CdGAP	GTPase activating protein, Rac/Rho	NP_064656	12549	Arhgap31		mouse	T776	PHOSPHORYLATION	456517	TPAPPPPtPLEEEPE		activity, inhibited	transcription, altered			9159; 6713; 15278807	3	0	0	increases CdGAP expression 	
StAR	Carrier protein; Lipid binding protein; Mitochondrial	P51557	20845	Star		mouse	S232	PHOSPHORYLATION	2089100	VLHPLAGsPSKTKLT	START	enzymatic activity, induced				5014018	2	0	0	promotes progesterone production	
P130Cas	Adaptor/scaffold; Motility/polarity/chemotaxis	Q61140	12927	Bcar1		mouse	Y271	PHOSPHORYLATION	451537	NQYGQEVyDTPPMAV			carcinogenesis, induced; cell motility, induced			23013811	2	14	282	migration, invasion, metastasis	
Cdc25B iso2	EC 3.1.3.48; Motility/polarity/chemotaxis; Nuclear receptor co-regulator; PHOSPHATASE; Protein phosphatase, dual-specificity	P30305-2	994	CDC25B	20p13	human	S146	PHOSPHORYLATION	465509	PVRLLGHsPVLRNIT	M-inducer_phosp	intracellular localization	cell cycle regulation			8016	1	2	2		
NPHS1	Cell adhesion; Immunoglobulin superfamily; Membrane protein, integral	Q9QZS7	54631	Nphs1		mouse	Y1191	PHOSPHORYLATION	2299202	MAFPGHLyDEVERVY		molecular association, regulation	cytoskeletal reorganization	Nck1(INDUCES)		2195712	2	0	0		
GATA2	Transcription factor	P23769	2624	GATA2	3q21.3	human	S401	PHOSPHORYLATION	455583	QTRNRKMsNKSKKSK		intracellular localization; activity, inhibited	transcription, altered; cell growth, altered			5526	1	0	5		
p21Cip1	Cell cycle regulation; Inhibitor protein	Q683K8		cdkn1a		dog	S91	PHOSPHORYLATION	4943330	TCTLLPHsPERPEAS		protein stabilization	cell cycle regulation			25712623	1	0	0		
NIPA	Cell cycle regulation; Ubiquitin conjugating system	Q86WB0	51530	ZC3HC1	7q32.2	human	S359	PHOSPHORYLATION	483339	TRSWDSSsPVDRPEP		molecular association, regulation	cell cycle regulation	SKP1A(DISRUPTS)		11952	2	11	11		
TIF1A	Transcription initiation complex	Q9NYV6	54700	RRN3	16p12	human	S649	PHOSPHORYLATION	448839	PVLYMQPsPL_____		activity, induced; molecular association, regulation	transcription, induced	POLR1B(INDUCES)		2005; 2915507; 4284	4	1	1		
GNRHR2	GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR	Q95MG6	100399755	LOC100399755		monkey	S339	PHOSPHORYLATION	454394	QELSMDSsREEGSRR		receptor internalization, altered				4259	1	0	0		
Myt1	EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, Other; Protein kinase, dual-specificity	Q99640	9088	PKMYT1	16p13.3	human	T461	PHOSPHORYLATION	11331002	STPRSRCtPRDALDL		molecular association, regulation		Pin1(INDUCES)		7981800	1	0	0		
ADRB2	GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR	P07550	154	ADRB2	5q31-q32	human	T360	PHOSPHORYLATION	5403100	GYSSNGNtGEQSGYH		molecular association, regulation; receptor internalization, altered		ARRB2(INDUCES)		5354441	2	0	0	PD-N mutant (residues 355-364) failed to recruit ARRB2 to the plasma membrane 	
VPS35	Vesicle protein	Q9EQH3	65114	Vps35		mouse	S7	PHOSPHORYLATION	486029	_MPTTQQsPQDEQEK		molecular association, regulation	signaling pathway regulation		Other(DISRUPTS)	29642715	1	8	1	Mutation of S7 to alanine inhibited the insulin-stimulated dissociation of VPS35 from low-density microsomal membranes, and inhibited the insulin-stimulated decrease in GLUT4 expression	
DAB1 iso2	Adaptor/scaffold	P97318-2	13131	Dab1		mouse	T470	PHOSPHORYLATION	479418	DISQLNLtPVTSTTP		phosphorylation				11449	1	0	0	inhibits tyrosine phosphorylation	
N-WASP	Adaptor/scaffold; Motility/polarity/chemotaxis	O08816	682507	Wasl		rat	T259	PHOSPHORYLATION	23003804	IYDFIEKtGGVEAVK		molecular association, regulation; protein conformation	cytoskeletal reorganization			22958935	1	0	0	 inhibits actin polymerization in vitro; inhibits the filopodia promoting activity of N-WASP	
GR	DNA binding protein; Mitochondrial; Nuclear receptor; Transcription factor	P04150	2908	NR3C1	5q31.3	human	S134	PHOSPHORYLATION	3178932	ANLNRSTsVPENPKS	GCR		transcription, altered			21385522	3	3	5		
Btk	EC 2.7.10.2; KINASE; Kinase, protein; Protein kinase, TK; Protein kinase, tyrosine (non-receptor)	P35991	12229	Btk		mouse	Y551	PHOSPHORYLATION	447486	RYVLDDEyTSSVGSK	Pkinase_Tyr	enzymatic activity, induced	cell growth, altered	GTF2I(NOT_REPORTED)		476; 1633; 475	22	9	135	PI 3-kinase is required for BTK activation and transformation. 	
FZR1	Ubiquitin conjugating system	Q9UM11	51343	FZR1	19p13.3	human	S163	PHOSPHORYLATION	4661904	KSQKLLRsPRKPTRK		activity, inhibited	apoptosis, induced			4641433	1	0	0	inhibits cyclin B1 degradation	
CAMKK1	EC 2.7.11.17; KINASE; Kinase, protein; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor)	Q8N5S9	84254	CAMKK1	17p13.2	human	S475	PHOSPHORYLATION	486103	RREERSMsAPGNLLV		molecular association, regulation; enzymatic activity, inhibited		14-3-3 eta(INDUCES)		1968358	2	6	7	14-3-3 inhibits CAMKK1 activity. 	
AP2B1	Vesicle protein	P63010	163	AP2B1	17q11.2-q12	human	Y737	PHOSPHORYLATION	450538	THRQGHIyMEMNFTN	Alpha_adaptinC2	molecular association, regulation		ARRB1(DISRUPTS); AGTRAP(DISRUPTS)		11497	2	4	6		
MEK1	EC 2.7.12.2; KINASE; Kinase, protein; Protein kinase, STE; Protein kinase, dual-specificity	Q02750	5604	MAP2K1	15q22.1-q22.33	human	T292	PHOSPHORYLATION	448287	ETPPRPRtPGRPLSS	Pkinase	molecular association, regulation; enzymatic activity, inhibited		ERK2(INDUCES); ERK1(DISRUPTS); RAF1(INDUCES)		1816; 1165; 7231; 1164	10	1	0		
PLM	Cell surface; Channel, misc.; Membrane protein, integral	P56513	476487	FXYD1		dog	S83	PHOSPHORYLATION	451424	EEGTFRSsIRRLSTR	IncA	activity, induced				3335909	18	13	60	increases Na(+) affinity of ATP1A1/B1	
Smad1	DNA binding protein; Transcription factor	Q15797	4086	SMAD1	4q31	human	S465	PHOSPHORYLATION	448363	HNPISSVs_______		activity, induced; molecular association, regulation; intracellular localization	transcription, altered	Smad4(INDUCES)		3385; 785	8	8	59		
LNK	Adaptor/scaffold	O09039	16923	Sh2b3		mouse	Y536	PHOSPHORYLATION	476934	LRAIDNQyTPLSQLC		activity, induced; molecular association, regulation	cell motility, altered; cell growth, altered	LNK(INDUCES)		6011126	2	1	10		
FRA1	DNA binding protein; Transcription factor	P15407	8061	FOSL1	11q13	human	S265	PHOSPHORYLATION	478352	PSSDPLGsPTLLAL_		protein stabilization				9581	3	3	6		
Mnk2	EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, CAMK; Protein kinase, Ser/Thr (non-receptor); Translation	Q8CDB0	17347	Mknk2		mouse	S434	PHOSPHORYLATION	456331	CLQLSPPsQSKLAQR		molecular association, regulation		ERK1(INDUCES)		10296912	1	2	1		
STAT5B	DNA binding protein; Transcription factor	P51692	6777	STAT5B	17q11.2	human	S731	PHOSPHORYLATION	448751	TYMDQAPsPAVCPQA		activity, induced	transcription, altered			1172807	10	0	0	increases the basal transcriptional activity of the Y740/743 mutant comparing with the wt STAT5B 	
S6	Translation	P62754	20104	Rps6		mouse	S235	PHOSPHORYLATION	448092	IAKRRRLsSLRASTS			carcinogenesis, induced			27519661	131	26	946	Increased Kras induced pancreatic lesions, metaplastic foci, p53 expression	
TAK1	EC 2.7.11.25; KINASE; Kinase, protein; Protein kinase, Ser/Thr (non-receptor); Protein kinase, TKL	O43318	6885	MAP3K7	6q15	human	S192	PHOSPHORYLATION	448289	HMTNNKGsAAWMAPE	Pkinase_Tyr	phosphorylation; enzymatic activity, induced				14780521; 4328	4	0	0		
Notch 1	Membrane protein, integral; Motility/polarity/chemotaxis; Receptor, misc.; Transcription factor	Q01705	18128	Notch1		mouse	K1764	ACETYLATION	18899501	LWFPEGFkVSEASKK		protein stabilization; ubiquitination				18899000	1	1	0		
MEKK2	EC 2.7.11.25; KINASE; Kinase, protein; Protein kinase, STE; Protein kinase, Ser/Thr (non-receptor)	Q61083	26405	Map3k2		mouse	T283	PHOSPHORYLATION	28761201	EYNDGRKtFPRARRT		molecular association, regulation; enzymatic activity, inhibited; protein conformation	cell growth, induced; transcription, inhibited	14-3-3 epsilon(INDUCES)		28722174	1	0	0	dimerization, transcription of GAL4-c-Jun was increased in T283A mutant	
myocardin	Cell development/differentiation; Transcription factor	Q8VIM5	214384	Myocd		mouse	S454	PHOSPHORYLATION	3627508	TGFYHFGsTSSSPPI			transcription, inhibited			6856	1	0	0		
FOXO3A	Autophagy; DNA binding protein; Transcription factor	O43524	2309	FOXO3	6q21	human	S315	PHOSPHORYLATION	449109	DFRSRTNsNASTVSG		intracellular localization	cell cycle regulation; apoptosis, inhibited; transcription, inhibited			679	4	0	1		
MITF iso8	DNA binding protein; Transcription factor	Q08874-8	17342	Mitf		mouse	S307	PHOSPHORYLATION	451221	IPSTGLCsPDLVNRI	DUF3371	activity, induced				3457	2	10	5		
VCP	Chaperone; DNA repair; Endoplasmic reticulum; Hydrolase	P55072	7415	VCP	9p13.3	human	S352	PHOSPHORYLATION	457556	AATNRPNsIDPALRR	AAA		apoptosis, inhibited			7785	2	2	0		
GEM	G protein; G protein, monomeric, RGK	P55040	2669	GEM	8q13-q21	human	S289	PHOSPHORYLATION	450648	AFKLKSKsCHDLSVL		protein stabilization; molecular association, regulation	cytoskeletal reorganization	14-3-3 beta(INDUCES); KPNA5(DISRUPTS)		1172801; 3061	2	5	0	interaction abolished in triple phosphomimetic mutant S261/287/289D; Cell flattening and neurite extension; Mutation of either S23 or  S289 inhibits binding to 14-3-3	
FOXO1A	DNA binding protein; Nuclear receptor co-regulator; Transcription factor	Q12778	2308	FOXO1	13q14.1	human	K265	ACETYLATION	459033	DNNSKFAkSRSRAAK	Fork_head	intracellular localization; phosphorylation				15022750	4	0	0		
VAV1	Guanine nucleotide exchange factor, Rac/Rho; Motility/polarity/chemotaxis	P27870	22324	Vav1		mouse	Y160	PHOSPHORYLATION	447865	AEEDEDLyDCVENEE		molecular association, regulation; protein conformation; activity, inhibited; phosphorylation	cytoskeletal reorganization; transcription, altered; cell growth, altered	VAV1(INDUCES)		13354739; 1976	5	0	0		
FAK	EC 2.7.1.112; EC 2.7.10.2; KINASE; Kinase, protein; Protein kinase, TK; Protein kinase, tyrosine (non-receptor)	P34152	14083	Ptk2		mouse	Y428	PHOSPHORYLATION	447887	SGDETDDyAEIIDEE		activity, induced; molecular association, regulation; enzymatic activity, induced	cell adhesion, induced; cell motility, altered; cytoskeletal reorganization; cell adhesion, altered; signaling pathway regulation; transcription, altered	Src(INDUCES); PLCG1(INDUCES)		4080; 15031324; 10001309; 25255511; 3394320; 9938537; 1173011; 7309834; 14821602	234	21	470		
PML iso4	Transcription factor; Tumor suppressor; Ubiquitin conjugating system	P29590-4	5371	PML	15q22	human	S527	PHOSPHORYLATION	451472	PHLDGPPsPRSPVIG	DUF3583	protein stabilization	apoptosis, altered			3657	2	15	11	Phosphorylation of PML is associated with enhanced sumoylation and apoptosis induced by As2O3. 	
mGluR7	GPCR, family 3; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR	Q68ED2	108073	Grm7		mouse	S862	PHOSPHORYLATION	2846504	NVQKRKRsFKAVVTA		molecular association, regulation; receptor internalization, altered		calmodulin(DISRUPTS); PICK1(INDUCES)		2831758	3	0	0		
NRF2	DNA binding protein; Transcription factor	Q60795	18024	Nfe2l2		mouse	S347	PHOSPHORYLATION	18258502	NTSPSRAsPEHSVES		protein degradation; molecular association, regulation		BTRC(INDUCES)		18021029	2	0	0		
DDX3	Cell cycle regulation; EC 3.6.1.-; EC 3.6.4.13; Helicase; Spliceosome; Translation initiation; Tumor suppressor	O00571	1654	DDX3X	Xp11.3-p11.23	human	T323	PHOSPHORYLATION	457784	GCHLLVAtPGRLVDM	DEAD	enzymatic activity, inhibited	translation, altered; cell growth, altered			8475010; 7310	2	6	0		
dCK	EC 2.7.1.74; Kinase, other; Nucleotide Metabolism - purine; Nucleotide Metabolism - pyrimidine	P27707	1633	DCK	4q13.3-q21.1	human	T3	PHOSPHORYLATION	460584	_____MAtPPKRSCP		protein stabilization; phosphorylation				14851000	3	3	0		
NFM	Cytoskeletal protein	P08553	18040	Nefm		mouse	S537	PHOSPHORYLATION	448043	EEDEGVKsDQAEEGG			cytoskeletal reorganization			7072905	3	5	0	slightly altered axoplasmic organization in 7S/A mice mutant	
eIF4G	Translation; Translation initiation	D3ZU13	287986	Eif4g1		rat	S1147	PHOSPHORYLATION	449800	VVQRSSLsRERGEKA		activity, induced; molecular association, regulation		eIF4E(INDUCES)		7281	16	11	1		
p53	Activator protein; DNA binding protein; Motility/polarity/chemotaxis; Nuclear receptor co-regulator; Transcription factor; Tumor suppressor	P04637	7157	TP53	17p13.1	human	K386	UBIQUITINATION	464662	RHKKLMFkTEGPDSD		protein degradation; intracellular localization	transcription, induced; transcription, inhibited			5085401; 12136; 7920	9	0	1	K370/372/373/381/382/386/R mutant shows 613-fold activation of p53; stimulates the transcriptional activity of p53	
DAT	Membrane protein, integral; Membrane protein, multi-pass; Transporter	Q01959	6531	SLC6A3	5p15.3	human	T62	PHOSPHORYLATION	451139	VEAQDREtWGKKIDF	SNF	protein conformation				5930039	2	0	0		
PXN	Adaptor/scaffold; Cell adhesion; Cytoskeletal protein; Motility/polarity/chemotaxis	P49024	395832	PXN		chicken	T403	PHOSPHORYLATION	448766	VVTALDRtWHPEHFF	LIM	intracellular localization	cell adhesion, altered			1936	1	1	0		
C3aR	GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR	Q16581	719	C3AR1	12p13.31	human	T466	PHOSPHORYLATION	27145809	SEELTRStHCPSNNV		receptor internalization, induced; molecular association, regulation	transcription, inhibited	ARRB1(INDUCES)		27132477	1	0	0		
NPAT	Cell cycle regulation; Transcription regulation	Q14207	4863	NPAT	11q22-q23	human	S779	PHOSPHORYLATION	2286402	ILSSPTKsPTKNAEL			transcription, induced			2285900	1	1	0	multiple sites deletion mutant	
Sin1	Adaptor/scaffold	Q9BPZ7	79109	MAPKAP1	9q33.3	human	S260	PHOSPHORYLATION	28758701	PIHKFGFsTLALVEK	SIN1	protein stabilization	cell growth, induced			28722170	1	0	0	high abundance of mTORC2 	
tau	Cytoskeletal protein	P10637	17762	Mapt		mouse	S506	PHOSPHORYLATION	447929	GSRSRTPsLPTPPTR		molecular association, regulation		AKAP5(INDUCES); PKAR2B(INDUCES); PKACB(INDUCES)		2889	41	10	32		
IkB-beta	Inhibitor protein	Q15653	4793	NFKBIB	19q13.1	human	S313	PHOSPHORYLATION	452013	EKSGPCSsSSDSDSG		activity, induced; intracellular localization	transcription, altered; transcription, inhibited	CCDC32(INDUCES)		4914012; 3925; 12482224	3	0	0	Phosphorylation blocks NF-kB-directed transcription.; and in vivo, NFkB/Rel activation 	
Ets-1	DNA binding protein; Motility/polarity/chemotaxis; Transcription factor	P14921	2113	ETS1	11q23.3	human	S285	PHOSPHORYLATION	449318	QRVPSYDsFDSEDYP		molecular association, regulation; activity, inhibited	transcription, inhibited		DNA(DISRUPTS)	2182	3	4	49		
PAR1	Cell development/differentiation; GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR	P25116	2149	F2R	5q13	human	S400	PHOSPHORYLATION	3627504	DPSSYNSsGQLMASK		receptor desensitization, altered				4656	1	0	0	receptor shutoff (not internalization)	
PSD-95	Adaptor/scaffold	P31016	29495	Dlg4		rat	Y523	PHOSPHORYLATION	4093600	REDSVLSyETVTQME		activity, induced				4042520	2	0	0		
CAMKK1	EC 2.7.11.17; KINASE; Kinase, protein; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor)	Q8N5S9	84254	CAMKK1	17p13.2	human	S458	PHOSPHORYLATION	486077	KSMLRKRsFGNPFEP		enzymatic activity, inhibited				2852658	4	12	13	activity toward PKIV peptide	
IRAK1	EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, Ser/Thr (non-receptor); Protein kinase, TKL	P51617	3654	IRAK1	Xq28	human	T209	PHOSPHORYLATION	450949	LCEISRGtHNFSEEL		protein conformation; enzymatic activity, induced				3220	1	0	0		
DUSP8	EC 3.1.3.16; EC 3.1.3.48; Motility/polarity/chemotaxis; Protein phosphatase, dual-specificity	O09112	18218	Dusp8		mouse	T518	PHOSPHORYLATION	22598802	PPLDSPGtPSPDGPW		enzymatic activity, inhibited	signaling pathway regulation			22495309	1	1	0	activates JNK pathway	
SLP76	Adaptor/scaffold	Q60787	16822	Lcp2		mouse	Y145	PHOSPHORYLATION	448220	LVDDAADyEPPPSNN		molecular association, regulation; phosphorylation	cell differentiation, altered; apoptosis, altered; cytoskeletal reorganization; cell adhesion, altered; transcription, induced; transcription, altered	Btk(INDUCES)		2425220; 1967701; 2079; 6115903; 1606	14	0	0	mutation of this site impairs thrombus formation	
H3F3A	DNA binding protein	P84243	3020	H3F3A	1q42.12	human	S11	PHOSPHORYLATION	18545301	TKQTARKsTGGKAPR		activity, induced	cell cycle regulation; transcription, altered			5620; 5516	16	1	0		
P38A	EC 2.7.1.37; EC 2.7.11.24; KINASE; Kinase, protein; Protein kinase, CMGC; Protein kinase, Ser/Thr (non-receptor)	P70618	81649	Mapk14		rat	T180	PHOSPHORYLATION	447970	RHTDDEMtGYVATRW	Pkinase	enzymatic activity, induced	cell growth, altered			7472	305	34	1501		
FAM125B	Vesicle protein	Q9H7P6	89853	FAM125B	9q33.3	human	K290	UBIQUITINATION	15167003	KSLAEIEkEYEYSFR	DUF2464	intracellular localization				15026112	1	1	0		
mAChR M2	GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR	P08172	1129	CHRM2	7q31-q35	human	S290	PHOSPHORYLATION	459105	SNDSTSVsAVASNMR	7tm_1	receptor internalization, altered				7628	3	0	0	Mutation of S286 T287 S288 S290 to A caused a faster rate and a greater extent of receptor internalization after agonist stimulation (transients only, not observed in stables).  Mutation of all 8 sites prevented internalization (in both transients and stables).	
tau iso8	Cytoskeletal protein	P10636-8	4137	MAPT	17q21.1	human	S289	PHOSPHORYLATION	487456	LDLSNVQsKCGSKDN	Tubulin-binding	molecular association, regulation				19084437	1	2	0	in vitro microtubule binding	
HDAC3	Apoptosis; Cell cycle regulation; Deacetylase; EC 3.5.1.98; Nuclear receptor co-regulator; Transcription, coactivator/corepressor	O15379	8841	HDAC3	5q31	human	S424	PHOSPHORYLATION	455624	DHDNDKEsDVEI___		enzymatic activity, induced				5521	1	10	3		
Kv2.1	Channel, cation; Channel, ligand-gated; Channel, potassium; Membrane protein, integral; Membrane protein, multi-pass	P15387	25736	Kcnb1		rat	S444	PHOSPHORYLATION	4714867	ERAKRNGsIVSMNMK		activity, induced				21683711	1	6	0		
NRF2	DNA binding protein; Transcription factor	Q60795	18024	Nfe2l2		mouse	S40	PHOSPHORYLATION	450082	SREVFDFsQRQKDYE	N_NLPC_P60	protein stabilization; molecular association, regulation; intracellular localization		KEAP1(DISRUPTS)		11424219; 2661	8	0	0	increases cellular drug resistance and enhances cell survival	
NPHS1	Cell adhesion; Immunoglobulin superfamily; Membrane protein, integral	Q9R044	64563	Nphs1		rat	Y1228	PHOSPHORYLATION	469566	CEDPRGIyDQVAADM		molecular association, regulation	cytoskeletal reorganization	Nck1(NOT_REPORTED)		8285; 2195700	8	0	0		
ADRB2	GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR	P07550	154	ADRB2	5q31-q32	human	Y141	PHOSPHORYLATION	449832	AITSPFKyQSLLTKN	7tm_1	activity, induced				12660611	4	0	0		
FANCA	DNA repair	O15360	2175	FANCA	16q24.3	human	S1149	PHOSPHORYLATION	9802800	CLRSRDPsLMVDFIL		molecular association, regulation				8500	1	0	0	Complementation assays showed similar results for WT-FANCA and S1149A mutant. 	
SNAP23	Vesicle protein	O00161	8773	SNAP23	15q14	human	T24	PHOSPHORYLATION	11486600	TDESLEStRRILGLA	Prominin; DUF1664; V-SNARE_C	molecular association, regulation		STX4(INDUCES)		11484400	1	2	1		
TH	Amino Acid Metabolism - tyrosine; EC 1.14.16.2; Endoplasmic reticulum; Mitochondrial; Oxidoreductase; Vesicle protein	P24529	21823	Th		mouse	S40	PHOSPHORYLATION	448545	RFIGRRQsLIEDARK	Chorion_2; TOH_N	enzymatic activity, induced				6782006; 1173020	46	6	11	S40 is localized in 30% of cholinergic cell bodies.	
VASP	Cytoskeletal protein; Motility/polarity/chemotaxis	P70460	22323	Vasp		mouse	S317	PHOSPHORYLATION	469024	TTLPRMKsSSSVTTS		molecular association, regulation	cell adhesion, induced			21390216	2	8	46	increased actin filament binding in vitro, increased aggregation of cells, increased VASP at cell-cell adhesions  ; increased actin filament binding in vitro, increased aggregation of cells, increased VASP at cell-cell adhesions  
	
PREX1	Guanine nucleotide exchange factor, Rac/Rho	Q8TCU6	57580	PREX1	20q13.13	human	S319	PHOSPHORYLATION	4735252	KSTKRTKsINGSLYI	PH	activity, inhibited				18668001	1	3	0		
KSR	KINASE; Kinase, protein; Protein kinase, Ser/Thr (non-receptor); Protein kinase, TKL	Q61097	16706	Ksr1		mouse	S297	PHOSPHORYLATION	449296	PTLTRSKsHESQLGN		molecular association, regulation		14-3-3 beta(INDUCES)		2168	2	11	2		
SCN10A	Channel, sodium; Membrane protein, integral; Membrane protein, multi-pass	Q62968		Scn10a		rat	S556	PHOSPHORYLATION	2482301	PRSPLPQsPNPGRRH		activity, induced				2451813	1	0	0	increases SCN10A sodium channel current density  	
CCND2	Cell cycle regulation; Motility/polarity/chemotaxis	P30280	12444	Ccnd2		mouse	T280	PHOSPHORYLATION	469202	EDPDQATtPTDVRDV		protein degradation; intracellular localization				2856303	2	3	9	degradation of itself and p27Kip1	
HDAC5	EC 3.5.1.98; Hydrolase	Q9UQL6	10014	HDAC5	17q21	human	S661	PHOSPHORYLATION	7237900	QALGRTQsSPAAPGG		intracellular localization		14-3-3 beta(INDUCES)		7119503	1	4	14	14-3-3-dependent nuclear export	
FOXO3A	Autophagy; DNA binding protein; Transcription factor	O43524	2309	FOXO3	6q21	human	S209	PHOSPHORYLATION	464289	SSAGWKNsIRHNLSL	Fork_head	molecular association, regulation; intracellular localization		14-3-3 beta(DISRUPTS)		7891	3	0	0		
BRAF	EC 2.7.1.37; EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, Ser/Thr (non-receptor); Protein kinase, TKL	P15056	673	BRAF	7q34	human	T440	PHOSPHORYLATION	447806	EDRNRMKtLGRRDSS		enzymatic activity, inhibited				1748; 6588	2	1	2		
Abl	EC 2.7.1.112; EC 2.7.10.2; KINASE; Kinase, protein; Protein kinase, TK; Protein kinase, tyrosine (non-receptor)	P00519	25	ABL1	9q34.1	human	S619	PHOSPHORYLATION	1779805	PTPPKRSsSFREMDG		molecular association, regulation; phosphorylation; enzymatic activity, induced		Abi-2(DISRUPTS)		1713156	1	0	0	interaction in vitro and in vivo;  phosphorylation of this site enhances the association and phosphorylation of the Abl substrate, Crk.	
SAV1	Adaptor/scaffold	Q9H4B6	60485	SAV1	14q13-q23	human	T26	PHOSPHORYLATION	4270990	GKYVKKEtSPLLRNL	SynMuv_product	protein conformation	apoptosis, induced			21386602	1	2	0	 self-dimerization; increase in protein level	
Kir5.1	Membrane protein, integral; Membrane protein, multi-pass	P52191	29719	Kcnj16		rat	S417	PHOSPHORYLATION	451508	LNRISMEsQM_____		molecular association, regulation; intracellular localization; activity, inhibited		PSD-95(DISRUPTS)		3687	1	1	0		
MEK1	EC 2.7.12.2; KINASE; Kinase, protein; Protein kinase, STE; Protein kinase, dual-specificity	Q02750	5604	MAP2K1	15q22.1-q22.33	human	S218	PHOSPHORYLATION	448514	VSGQLIDsMANSFVG	Pkinase	enzymatic activity, induced	cell cycle regulation; cell growth, altered			5708; 5672; 7324124; 6047; 1740; 3342623; 5930044; 7839	90	5	54		
STX1B	Membrane protein, integral; Vesicle protein	P61265	24923	Stx1b		rat	S14	PHOSPHORYLATION	450122	ELRSAKDsDDEEEVV	DUF3077	molecular association, regulation		SNAP-25(INDUCES)		4387	2	16	5		
PTP1B	EC 3.1.3.48; Motility/polarity/chemotaxis; PHOSPHATASE; Phosphatase; Protein phosphatase, tyrosine (non-receptor)	O13016	395688	PTPN1		chicken	Y152	PHOSPHORYLATION	449312	ISEDIKSyYTVRQLE	Y_phosphatase	molecular association, regulation		CDH2(INDUCES)		2787	4	0	1		
NOXA1	Activator protein	Q86UR1	10811	NOXA1	9q34.3	human	Y110	PHOSPHORYLATION	17303900	RGHAAIDyTQLGLRF		activity, induced; molecular association, regulation	carcinogenesis, altered; cytoskeletal reorganization	SH3PXD2B(INDUCES)		15755103	1	0	0		
GTF2I iso2	DNA binding protein; Transcription, coactivator/corepressor	P78347-2	2969	GTF2I	7q11.23	human	S633	PHOSPHORYLATION	452350	QSPKRPRsPGSNSKV			transcription, altered			8845	1	5	26		
AP-2 alpha	DNA binding protein; Transcription factor	P05549	7020	TFAP2A	6p24	human	S258	PHOSPHORYLATION	5024712	GVLRRAKsKNGGRSL	TF_AP-2	molecular association, regulation	transcription, altered		DNA(INDUCES)	5014009	2	0	0		
Bcl-10	Apoptosis; Transcription, coactivator/corepressor	O95999	8915	BCL10	1p22	human	S231	PHOSPHORYLATION	469573	PLRSRTVsRQ_____		molecular association, regulation; intracellular localization		Bcl-3(INDUCES)		8297	1	0	1		
CREB	DNA binding protein; Transcription factor	P15337	81646	Creb1		rat	S133	PHOSPHORYLATION	448228	EILSRRPsYRKILND	pKID	activity, induced; molecular association, regulation; intracellular localization; protein conformation; phosphorylation	transcription, induced; transcription, altered; cell growth, altered	CREM(INDUCES); CBP(INDUCES)	DNA(INDUCES)	4862609; 721; 2826; 7991109; 2736; 27619358; 3342607; 6952; 4533; 7451001; 2300; 6295; 4862612; 2301; 4862613; 2681; 4313614; 13788306; 2851; 4862607; 1716; 2571; 6266; 6215; 2777	214	1	61	regulate cell proliferation in dentate gyrus following ischemia; Activation through p38 MAPK, ERK and CaMK4	
UHRF1	DNA binding protein; EC 6.3.2.-; EC 6.3.2.19; Ligase; Transcription factor; UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase	Q96T88	29128	UHRF1	19p13.3	human	S95	PHOSPHORYLATION	3210060	SELSDTDsGCCLGQS		protein degradation; molecular association, regulation		BTRC(INDUCES)		27519630	1	3	4		
MOR-1	GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR	P33535	25601	Oprm1		rat	T357	PHOSPHORYLATION	3063303	FCIPTSStIEQQNST		receptor desensitization, altered; phosphorylation				8649	1	1	0		
ataxin-3 iso2	DNA repair; EC 3.4.19.12; EC 3.4.22.-; Protease; Transcription regulation; Ubiquitin-specific protease	P54252-2	4287	ATXN3	14q21	human	S347	PHOSPHORYLATION	9441000	LQAAVTMsLETVRND	OmpH; Dicty_REP; UIM	activity, induced; protein stabilization; intracellular localization	transcription, altered			9201021	1	0	0		
CREM iso3	DNA binding protein; Transcription factor	P27699	12916	Crem		mouse	S290	PHOSPHORYLATION	450066	ASPGSLHsPQQLAEE		activity, inhibited	transcription, altered			2633	4	7	1		
PKD1	Autophagy; EC 2.7.11.13; KINASE; Kinase, protein; Motility/polarity/chemotaxis; Protein kinase, CAMK; Protein kinase, Ser/Thr (non-receptor)	Q15139	5587	PRKD1	14q11	human	S910	PHOSPHORYLATION	447632	KALGERVsIL_____		enzymatic activity, induced				18410803; 7765	33	6	0		
MEKK2	EC 2.7.11.25; KINASE; Kinase, protein; Protein kinase, STE; Protein kinase, Ser/Thr (non-receptor)	Q9Y2U5	10746	MAP3K2	2q14.3	human	S520	PHOSPHORYLATION	1869000	LSGTGMKsVTGTPYW	Pkinase	phosphorylation; enzymatic activity, induced	transcription, altered			1903001	2	2	0	Mutation of S520A inhibits activation and is the key residue.  Double mutation of T522A,T524A reduces activation effect.  T522A seems to have the least effect of the three single mutations.  The triple STT to AAA mutation is akin to kinase dead.  Activation leads to Erk5 and JNKK2 phosphorylation/activation.	
SLC5A5	Membrane protein, integral; Membrane protein, multi-pass; Transporter	Q92911	6528	SLC5A5	19p13.11	human	S43	PHOSPHORYLATION	990307	LARGGQRsAEDFFTG		activity, induced				970026	1	1	1		
TIF1B	EC 6.3.2.-; KINASE; Kinase, protein; Ligase; Nuclear receptor co-regulator; Protein kinase, ATYPICAL; Protein kinase, atypical; Transcription, coactivator/corepressor; UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase	Q13263	10155	TRIM28	19q13.4	human	Y449	PHOSPHORYLATION	3576406	PMEVQEGyGFGSGDD		molecular association, regulation; phosphorylation	DNA repair, induced	HP1 alpha(INDUCES)	DNA(NOT_REPORTED)	27959900	1	1	2	stimulates phosphorylation of TIF1B S473 and TIF1B S824 in DNA damage response; involved in DNA damage response; inhibits association of HP1alpha with chromatin	
CDK7	EC 2.7.11.22; EC 2.7.11.23; KINASE; Kinase, protein; Nuclear receptor co-regulator; Protein kinase, CMGC; Protein kinase, Ser/Thr (non-receptor)	P50613	1022	CDK7	5q12.1	human	S164	PHOSPHORYLATION	450041	GLAKSFGsPNRAYTH	Pkinase		cell cycle regulation; transcription, altered			13245301	3	23	18		
TERT	DNA binding protein; EC 2.7.7.49; Transferase	O14746	7015	TERT	5p15.33	human	Y707	PHOSPHORYLATION	450084	QDPPPELyFVKVDVT	RVT_1	molecular association, regulation; intracellular localization	apoptosis, altered	RAN(INDUCES)		5007904; 2670; 13359103	3	0	0		
Dok1	Adaptor/scaffold; Motility/polarity/chemotaxis	P97465	13448	Dok1		mouse	Y146	PHOSPHORYLATION	455786	EMLENSLySPTWEGS		molecular association, regulation	cell cycle regulation; cell motility, altered; cell growth, altered	Dok1(INDUCES)		5938; 2790302	2	1	3		
MYPT1	Motility/polarity/chemotaxis; Protein phosphatase, regulatory subunit	Q10728	116670	Ppp1r12a		rat	S473	PHOSPHORYLATION	3174680	GVIRSASsPRLSSSL		molecular association, regulation		PLK1(INDUCES)		2915505	2	2	7		
ROMK	Channel, potassium; Membrane protein, integral; Membrane protein, multi-pass	P48048	3758	KCNJ1	11q24	human	S4	PHOSPHORYLATION	2813507	____MNAsSRNVFDT		activity, induced; intracellular localization				8783	2	0	0		
doublecortin	Cytoskeletal protein; Motility/polarity/chemotaxis	Q9ESI7	84394	Dcx		rat	S332	PHOSPHORYLATION	451363	STPKSKQsPISTPTS			cell growth, altered			17675046	4	3	16	controls axon branching morphogenesis	
JunD	Motility/polarity/chemotaxis; Transcription factor	P15066	16478	Jund		mouse	T117	PHOSPHORYLATION	473545	SNGLVTTtPTSTQFL	Jun		transcription, altered			9207	1	0	3		
DARPP-32	Motility/polarity/chemotaxis; Protein phosphatase, regulatory subunit	Q60829	19049	Ppp1r1b		mouse	S130	PHOSPHORYLATION	448046	EEDEEEDsQAEVLKG	DARPP-32; PPP4R2; Nop14; Nucleoplasmin; NOA36	activity, induced				6256	12	1	8		
IKKA	EC 2.7.11.10; KINASE; Kinase, protein; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor)	O15111	1147	CHUK	10q24-q25	human	T23	PHOSPHORYLATION	447780	EMRERLGtGGFGNVC	Pkinase	phosphorylation; enzymatic activity, induced	apoptosis, altered; apoptosis, inhibited; transcription, induced; transcription, altered			4282200; 12735103; 6115915; 2501	5	1	0		
SSTR5	Cell cycle regulation; GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR	P35346	6755	SSTR5	16p13.3	human	T247	PHOSPHORYLATION	1779800	RRSERKVtRMVLVVV	7tm_1	molecular association, regulation; receptor internalization, altered		ARRB2(INDUCES)		1713149	1	0	0		
ATF-2	C2H2-type zinc finger protein; Transcription factor	P15336	1386	ATF2	2q32	human	T73	PHOSPHORYLATION	451439	ADQTPTPtRFLKNCE		activity, induced; protein stabilization	transcription, induced			3646	4	6	8		
MZF-1	C2H2-type zinc finger protein; DNA binding protein; Transcription factor	O70162	109889	Mzf1		mouse	S374	PHOSPHORYLATION	448856	SLSGQIQsPTTEGGF		activity, inhibited				1891	1	0	0	S295A substitution correlates with increased transactivation activity, implying that phosphorylation can inhibit the transcriptional activation of MZF-2A.  Substitution of three sites (S257/275/295A) further inhibited transcription, suggesting that phosphorylation of these three residues cooperatively inhibits transactivation.	
NOXO1 iso3	Adaptor/scaffold	Q8NFA2-3			16p13.3	human	T341	PHOSPHORYLATION	28758706	AIQSRCCtVTRRALE	p47_phox_C	molecular association, regulation		NOXA1(INDUCES)		28723107	1	1	0		
GYS1	Carbohydrate Metabolism - starch and sucrose; EC 2.4.1.11; Transferase	P13834	100008660	GYS1		rabbit	S645	PHOSPHORYLATION	448238	RPASVPPsPSLSRHS	Glycogen_syn	enzymatic activity, inhibited				9217; 3399; 2739; 1381; 4917204; 3738	20	13	7		
TORC2	Transcription, coactivator/corepressor	Q53ET0	200186	CRTC2	1q21.3	human	S171	PHOSPHORYLATION	454622	SALNRTSsDSALHTS	TORC_M		transcription, inhibited			2461600	12	4	8		
Wee1	EC 2.7.10.2; KINASE; Kinase, protein; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor)	P30291	7465	WEE1	11p15.3-p15.1	human	S53	PHOSPHORYLATION	451131	GHSTGEDsAFQEPDS		protein degradation; molecular association, regulation	cell cycle regulation	BTRC(INDUCES); FBW1B(INDUCES)		4215; 3333; 6704	4	0	1		
SCN5A	Channel, sodium; Membrane protein, integral; Membrane protein, multi-pass	Q14524	6331	SCN5A	3p21	human	Y1495	PHOSPHORYLATION	455660	TEEQKKYyNAMKKLG		activity, inhibited				5566	1	0	0	leads to a depolarizing shift in stead state inactivation	
AHCYL1	Amino Acid Metabolism - cysteine and methionine; EC 3.3.1.1; Hydrolase; Other Amino Acids Metabolism - selenoamino acid	Q80SW1	229709	Ahcyl1		mouse	S68	PHOSPHORYLATION	467244	RSLSRSIsQSSTDSY	Utp11	molecular association, regulation; phosphorylation		PPP1CA(INDUCES); IP3R1(INDUCES)		12068; 8190	3	2	1	binding to IP3R1 supresses its binding to IP3 and inhibits IP3-induced calcium release ; inhibits IP3 binding	
p53	Activator protein; DNA binding protein; Motility/polarity/chemotaxis; Nuclear receptor co-regulator; Transcription factor; Tumor suppressor	P04637	7157	TP53	17p13.1	human	S183	PHOSPHORYLATION	18675301	CPHHERCsDSDGLAP	P53	protein degradation; ubiquitination	cell cycle regulation; carcinogenesis, induced; apoptosis, inhibited; transcription, inhibited			25347042	2	1	0		
Rb	Nuclear receptor co-regulator; Transcription, coactivator/corepressor; Tumor suppressor	P13405	19645	Rb1		mouse	S788	PHOSPHORYLATION	447979	SPYKFSSsPLRIPGG	Rb_C	molecular association, regulation		E2F1(DISRUPTS)		1258	34	9	87		
CIITA	DNA binding protein; Transcription, coactivator/corepressor	P33076	4261	CIITA	16p13	human	S288	PHOSPHORYLATION	2286408	PDRPGSTsPFAPSAT		molecular association, regulation; intracellular localization; activity, inhibited	transcription, altered	exportin 1(INDUCES)		2195706; 8373	2	0	0		
VAV1	Guanine nucleotide exchange factor, Rac/Rho; Motility/polarity/chemotaxis	P15498	7409	VAV1	19p13.2	human	Y745	PHOSPHORYLATION	13209302	LTELVEFyQQNSLKD	SH2		cell differentiation, altered; cell motility, altered			13159410	1	1	0		
TTK	Cancer Testis Antigen (CTA); EC 2.7.12.1; KINASE; Kinase, protein; Protein kinase, Other; Protein kinase, dual-specificity	P33981	7272	TTK	6q13-q21	human	T686	PHOSPHORYLATION	487541	VKDSQVGtVNYMPPE	Pkinase	enzymatic activity, induced	cell cycle regulation			4042509; 2831759; 6277010	6	2	0		
utrophin	Dystrophin complex; Motility/polarity/chemotaxis	P46939	7402	UTRN	6q24	human	S1258	PHOSPHORYLATION	2525745	TLEERMKsTEVLPEK	Spectrin	molecular association, regulation		DAG1(INDUCES)		13164201	1	1	0		
EphB1	EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Protein kinase, TK; Protein kinase, tyrosine (receptor)	P54762	2047	EPHB1	3q21-q23	human	Y600	PHOSPHORYLATION	450470	IYIDPFTyEDPNEAV		molecular association, regulation		Src(NOT_REPORTED); Shc1(NOT_REPORTED)		3019	1	15	120		
WAVE2	Actin binding protein; Motility/polarity/chemotaxis	Q9Y6W5	10163	WASF2	1p36.11	human	S482	PHOSPHORYLATION	6377642	RRIAVEYsDSEDDSS		activity, inhibited	cytoskeletal reorganization			6337810	1	0	0		
NCAPG	Cell cycle regulation	Q9BPX3	64151	NCAPG	4p15.33	human	T308	PHOSPHORYLATION	5014903	LNALFSItPLSELVG		molecular association, regulation; intracellular localization			DNA(INDUCES)	5014017	1	0	0	regulates NCAPG localization with chromosomal DNA in mitotic cells	
NUP50	Nuclear import; Nucleoporin	Q9UKX7	10762	NUP50	22q13.31	human	S221	PHOSPHORYLATION	476622	KVAAETQsPSLFGST	DUF3534	molecular association, regulation		KPNB1(DISRUPTS)		9980430	1	15	15		
P2X1	Channel, ligand-gated; Membrane protein, integral; Membrane protein, multi-pass	P47824		P2rx1		rat	T18	PHOSPHORYLATION	3251800	AFFFEYDtPRMVLVR	P2X_receptor	activity, induced				8701	1	0	0	T18A and T19N mutations abolishes receptor current. 	
Notch 1	Membrane protein, integral; Motility/polarity/chemotaxis; Receptor, misc.; Transcription factor	Q01705	18128	Notch1		mouse	K2146	ACETYLATION	18899508	LKSATQGkKARKPST		protein stabilization; ubiquitination				18899000	1	1	0		
IKKB	EC 2.7.11.10; KINASE; Kinase, protein; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor)	O88351	16150	Ikbkb		mouse	S705	PHOSPHORYLATION	17934902	LPESDKKsEELVAEA	IKKbetaNEMObind	molecular association, regulation; phosphorylation		PPP2R3C(INDUCES)		17675011	1	0	0	interaction with PPP2R3C (aka G4-1) downregulates IKK-beta activity;  S181 phosphorylation increased in S679/682/689/692/697/701/705A mutant	
CRYAB	Chaperone	Q7M2W6	100519789	CRYAB		pig	S59	PHOSPHORYLATION	448783	PSFLRAPsWIDTGLS	Crystallin	intracellular localization				5797	32	14	0		
PIP5K1C	Carbohydrate Metabolism - inositol phosphate; EC 2.7.1.68; Kinase, lipid; Motility/polarity/chemotaxis	O60331	23396	PIP5K1C	19p13.3	human	Y649	PHOSPHORYLATION	450241	TDERSWVySPLHYSA		molecular association, regulation; phosphorylation		talin 1(INDUCES); AP-2 beta(INDUCES)		7746; 15675514; 7127	4	0	0	stimulates PIP5KG polarization	
hnRNP L	RNA binding protein; RNA splicing	P14866	3191	HNRNPL	19q13.2	human	S52	PHOSPHORYLATION	3180663	GRYYGGGsEGGRAPK			carcinogenesis, altered; cell growth, altered			17431505	1	7	1	regulates the alternative splicing of caspase-9	
NMDAR2A	Channel, ligand-gated; Membrane protein, integral; Membrane protein, multi-pass	Q12879	2903	GRIN2A	16p13.2	human	Y1387	PHOSPHORYLATION	455471	GRCPSDPyKHSLPSQ	NMDAR2_C	activity, induced				10274616	3	0	9	potentiation of receptor currents mediated by Src	
C/EBP-beta	DNA binding protein; Motility/polarity/chemotaxis; Transcription factor	P17676	1051	CEBPB	20q13.1	human	T266	PHOSPHORYLATION	448447	VKSKAKKtVDKHSDE	I_LWEQ; Nup54	molecular association, regulation			DNA(INDUCES)	4650404	4	0	0		
FAM125A	Adaptor/scaffold	Q96EY5	93343	FAM125A	19p13.11	human	Y204	PHOSPHORYLATION	469592	LRRNDSIyEASSLYG	DUF2464	molecular association, regulation; intracellular localization	cytoskeletal reorganization	CIN85(INDUCES); CD2AP(INDUCES)		8290	1	7	48	important for ligand-mediated EGFR internalization and downregulation	
LRP1	Cell surface; Membrane protein, integral; Motility/polarity/chemotaxis; Receptor, misc.	Q07954	4035	LRP1	12q13.3	human	T4460	PHOSPHORYLATION	12526700	GFQHQRMtNGAMNVE		molecular association, regulation; receptor internalization, altered		Shc1(INDUCES); GULP1(INDUCES); DAB1(INDUCES)		12482284	1	1	1		
p27Kip1	Cell cycle regulation; Inhibitor protein; Protein kinase, regulatory subunit	P46527	1027	CDKN1B	12p13.1-p12	human	Y74	PHOSPHORYLATION	475060	HKPLEGKyEWQEVEK	CDI	protein degradation; molecular association, regulation	cell cycle regulation	CCND1(INDUCES); CDK2(DISRUPTS); CDK4(INDUCES); CCNE1(DISRUPTS)		9301; 6011128	7	0	0		
FOXO3A	Autophagy; DNA binding protein; Transcription factor	O43524	2309	FOXO3	6q21	human	S425	PHOSPHORYLATION	2058400	TKGSGLGsPTSSFNS		protein degradation; molecular association, regulation; activity, inhibited	cell growth, altered	MDM2(INDUCES)		1968337	4	4	0	promotes tumorigenicity	
MRLC1	Contractile protein; Motility/polarity/chemotaxis	Q64122	296313	Myl9		rat	T19	PHOSPHORYLATION	1863501	KKRPQSAtSNVFAMF			cytoskeletal reorganization			22518523	16	23	265	 T19, S20 di-phosphorylation is recquired for dendritic spine maturation;  mono phosphorylation inhibits spine maturation.	
cPLA2	EC 3.1.1.4; EC 3.1.1.5; Lipid Metabolism - alpha-linolenic acid; Lipid Metabolism - arachidonic acid; Lipid Metabolism - ether lipid; Lipid Metabolism - glycerophospholipid; Lipid Metabolism - linoleic acid; Phospholipase	P47712	5321	PLA2G4A	1q25	human	S505	PHOSPHORYLATION	447597	LNTSYPLsPLSDFAT	PLA2_B	activity, induced; intracellular localization; enzymatic activity, induced	cell growth, altered	KSR(INDUCES)		7124714; 4862604; 8328; 6011114; 5626; 1968363	22	6	8	 augments aracadonic acid release, but is not essential; translocation to the perinuclear area in response to ionomycin and calcium ; regulates serum induced translocation of cPLA2 to  Golgi; S228 induced full activity, S505 partially; PLA2 binding to KSR1 is mediated by ERK .	
TBC1D1	GTPase activating protein, Rab; Ubiquitin-specific protease	Q86TI0	23216	TBC1D1	4p14	human	T596	PHOSPHORYLATION	1247778	AFRRRANtLSHFPIE		molecular association, regulation		14-3-3 sigma(INDUCES)		1968306	6	7	134		
C5aR	GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR	P21730	728	C5AR1	19q13.3-q13.4	human	S332	PHOSPHORYLATION	448822	EESVVREsKSFTRST		molecular association, regulation; receptor desensitization, altered		ARRB1(INDUCES); ARRB2(INDUCES)		1995; 9155; 1994	4	3	0	induces translocation of beta-arrestin into the plasma membrane	
HER4	EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Protein kinase, TK; Protein kinase, tyrosine (receptor)	Q15303	2066	ERBB4	2q33.3-q34	human	Y1150	PHOSPHORYLATION	458100	GELDEEGyMTPMRDK		molecular association, regulation		Arg(INDUCES); Syk(INDUCES); Crk(INDUCES)		4651319	0	1	4		
SQSTM1	Autophagy; Nuclear receptor co-regulator; Ubiquitin conjugating system	Q13501	8878	SQSTM1	5q35	human	T269	PHOSPHORYLATION	457004	GGKRSRLtPVSPESS		protein degradation; ubiquitination	cell cycle regulation; carcinogenesis, altered			17431509	2	33	104	protects cyclin B1 from ubiquitylation and degradation	
SLC3A2	Membrane protein, integral; Transporter	P08195	6520	SLC3A2	11q13	human	S406	PHOSPHORYLATION	6003504	LLTSSYLsDSGSTGE			cell adhesion, altered			5930022	1	0	0	enhances cell- cell interactions	
Pyk2	EC 2.7.10.2; KINASE; Kinase, protein; Nuclear receptor co-regulator; Protein kinase, TK; Protein kinase, tyrosine (non-receptor)	P70600	50646	Ptk2b		rat	Y579	PHOSPHORYLATION	447956	RYIEDEDyYKASVTR	Pkinase_Tyr	enzymatic activity, induced				1252	6	18	973		
Smad2	DNA binding protein; Transcription factor	Q15796	4087	SMAD2	18q21.1	human	S467	PHOSPHORYLATION	447495	SVRCSSMs_______		activity, induced; molecular association, regulation; intracellular localization	transcription, induced; transcription, altered	Smad4(INDUCES); TGFBR1(DISRUPTS)		814; 7324132; 2448; 5309416	28	0	5	nuclear localization; S464 not likely phosphorylated but is required for efficient phosphorylation of COOH terminus.	
DAB1	Adaptor/scaffold	Q8CJH2	266729	Dab1		rat	S491	PHOSPHORYLATION	479422	TPAPRQSsPSKSSAS		molecular association, regulation		CIN85(DISRUPTS); CD2AP(DISRUPTS)		1713130	7	0	0		
Kv1.4	Channel, potassium; Membrane protein, integral; Membrane protein, multi-pass	P15385	25469	Kcna4		rat	S229	PHOSPHORYLATION	457537	FFDRNRPsFDAILYY	K_tetra	intracellular localization				7116	1	0	0	Kv1.4  with  wild-type S229 or S229A had significant difference in current density but not in membrane potential or current shape  authors suggest that S229 is important to prevent Kv1.4 from trafficing to the membrane.  	
SP1	C2H2-type zinc finger protein; DNA binding protein; Transcription factor	P08047	6667	SP1	12q13.1	human	T739	PHOSPHORYLATION	448227	SEGSGTAtPSALITT		molecular association, regulation; protein stabilization	cell cycle regulation; transcription, induced; transcription, inhibited; transcription, altered	MYO3A(INDUCES); ACTB(INDUCES)	DNA(DISRUPTS)	4766; 13852001; 1968333; 4682; 1717; 27151700; 6829240	13	1	0	inhibits transcription of p16, p21 and SDH5	
OSMR	Membrane protein, integral; Receptor, cytokine	Q99650	9180	OSMR	5p13.1	human	Y839	PHOSPHORYLATION	475364	LTKPNYLyLLPTEKN		phosphorylation				2704330	2	0	5	important for  STAT5B activation	
Trad	EC 2.7.11.1; Guanine nucleotide exchange factor, Rac/Rho; KINASE; Kinase, protein; Protein kinase, CAMK; Protein kinase, Ser/Thr (non-receptor)	P97924	84009	Kalrn		rat	T1572	PHOSPHORYLATION	3363402	EPIQLPKtPAKLRNN			cell growth, altered			3301236	1	0	1	T1590D mutation increases Trad solubility	
C/EBP-beta	DNA binding protein; Motility/polarity/chemotaxis; Transcription factor	P17676	1051	CEBPB	20q13.1	human	S223	PHOSPHORYLATION	2902801	VPSGSSGsLSTSSSS		protein conformation				25229704	2	0	0		
IP3R1	Channel, calcium; Channel, ligand-gated; Membrane protein, integral; Membrane protein, multi-pass; Receptor, misc.	P29994	25262	Itpr1		rat	S1756	PHOSPHORYLATION	450682	RPSGRREsLTSFGNG		activity, induced; receptor inactivation, altered				5445; 4269	9	12	10	Mutation of site to Glu enhanced, while mutation to Ala inhibited, calcium release through IP3R1.; increases the open probability of the IP3R receptor Ca(2+) channel	
eNOS	Amino Acid Metabolism - arginine and proline; EC 1.14.13.39; Oxidoreductase	P29473	287024	NOS3		cow	T1177	PHOSPHORYLATION	467803	EVTSRIRtQSFSLQE		phosphorylation; enzymatic activity, induced				2531300	2	6	8	stimulates VASP S236 phosphorylation in the presence of angiotensin 2 (AngII)	
SLC9A5	Membrane protein, integral; Membrane protein, multi-pass; Transporter	Q14940	6553	SLC9A5	16q22.1	human	T714	PHOSPHORYLATION	20832302	EESDSSEtEKEDDEG		molecular association, regulation; activity, inhibited	endocytosis, induced	ARRB1(INDUCES)		20655009	1	0	0	In intact cells ARRB1 ST/AA mutant retained ability to form a complex. 	
TBX21	DNA binding protein; Transcription factor	Q9JKD8	57765	Tbx21		mouse	T302	PHOSPHORYLATION	27930807	ETQFIAVtAYQNAEI	T-box		transcription, inhibited			27902358	1	0	0	suppresses NFAT1 expression, critical for inhibition of NFAT1-mediated IL-2 and Th2 cytokine production 	
NCoA6	Nuclear receptor co-regulator; Transcription, coactivator/corepressor	Q14686	23054	NCOA6	20q11	human	S884	PHOSPHORYLATION	470103	NKDVTLTsPLLVNLL		molecular association, regulation	transcription, altered	ER-alpha(DISRUPTS); ER-beta(INDUCES)		8860	1	1	0	S884Y mutation had significant increase in binding to TRB,RXR, and ER-beta, but decreased  binding to ER-alpha.
Transcriptional activity  of S884Y is associated with its receptor binding affinity. S884 may interact with E380 of ER-alpha demonstrated by molecular modeling.  	
ZAP	RNA binding protein; Transferase	Q8K3Y6	252832	Zc3hav1		rat	S257	PHOSPHORYLATION	469059	RDRFLHNsLEFLSPV		activity, induced				25227647	1	10	16		
YAP1 iso2	Transcription, coactivator/corepressor	P46937-2	10413	YAP1	11q13	human	S127	PHOSPHORYLATION	448847	PQHVRAHsSPASLQL	FAM181	molecular association, regulation; intracellular localization	carcinogenesis, inhibited; cell growth, inhibited; transcription, inhibited	14-3-3 beta(INDUCES)		7124733; 13320408; 22689012	25	14	164	S127 phosphorylation shows YAP1 cytoplasmic localization, while dephosphorylation induces nuclear localization and transcription.  	
OGG1	DNA repair; Deoxyribonuclease; EC 3.2.2.-; EC 4.2.99.18; Lyase	O15527	4968	OGG1	3p26.2	human	S326	PHOSPHORYLATION	10036103	FSADLRQsRHAQEPP		enzymatic activity, inhibited				9985908	1	0	0		
CCND1	Activator protein; Nuclear receptor co-regulator	P24385	595	CCND1	11q13	human	T286	PHOSPHORYLATION	447839	EEVDLACtPTDVRDV		protein degradation; molecular association, regulation; ubiquitination; intracellular localization	cell cycle regulation; cell growth, altered	CDK4(DISRUPTS); SMARCA4(DISRUPTS); BTRC(INDUCES); CRYAB(INDUCES); exportin 1(INDUCES); PRMT5(DISRUPTS); FBXO31(INDUCES); WDR77(DISRUPTS)		4316000; 1465; 9401437; 6083; 2610810; 6924; 2016000; 5928; 1919605; 2582601; 17722104	25	2	1	CCND1 T286A mutant ; Mutant T286D  mutant is constitutively nuclear and stable.	
CXCR4	GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR	P61073	7852	CXCR4	2q21	human	Y157	PHOSPHORYLATION	455337	LLAEKVVyVGVWIPA	7tm_1; TM	phosphorylation	transcription, altered			4607	1	0	0		
PAG	Adaptor/scaffold; Membrane protein, integral	Q9JM80	64019	Pag1		rat	Y314	PHOSPHORYLATION	450659	EEEISAMySSVNKPG		molecular association, regulation; intracellular localization	cell cycle regulation; cell differentiation, altered; cytoskeletal reorganization; cell adhesion, altered	SOCS1(NOT_REPORTED); CTK(INDUCES); CSK(INDUCES); CSK(NOT_REPORTED); SOCS1(INDUCES)		6277005; 7572; 3114; 8287	8	17	623		
InsR	EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Protein kinase, TK; Protein kinase, tyrosine (receptor)	P06213	3643	INSR	19p13.3-p13.2	human	Y1355	PHOSPHORYLATION	447683	SLGFKRSyEEHIPYT		protein conformation; enzymatic activity, induced	cell cycle regulation; cell growth, altered			3856; 8369; 4048; 2653; 8589	14	4	2	antibodies against  Y1355 and Y1361 peptides stimulated cell proliferation.  ; autophosphorylation; decreases ERK activation; regulates cell proliferation in response to insulin but not IGF-1 on pp120	
FEN1	DNA binding protein; DNA repair; Deoxyribonuclease; EC 3.1.-.-; Ribonuclease	P39748	2237	FEN1	11q12	human	K168	SUMOYLATION	25724402	ASCAALVkAGKVYAA	XPG_I	protein degradation; ubiquitination				25712619	1	1	0		
LRP1	Cell surface; Membrane protein, integral; Motility/polarity/chemotaxis; Receptor, misc.	Q07954	4035	LRP1	12q13.3	human	Y4473	PHOSPHORYLATION	473712	VEIGNPTyKMYEGGE		molecular association, regulation		SNX17(DISRUPTS); SHP-2(INDUCES)		2704313	3	2	2		
TRF1	DNA binding protein	P54274	7013	TERF1	8q21.11	human	S435	PHOSPHORYLATION	3192037	KKLKLISsDSED___			apoptosis, induced		DNA(INDUCES)	3301227	1	2	0	 enhances binding of TRF1 to telomeric DNA in vivo and in vitro; regulated by phosphorylation of sites T344 and T371 by Cdc2	
ITCH	EC 6.3.2.-; EC 6.3.2.19; Ligase; UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase	Q8C863	16396	Itch		mouse	S199	PHOSPHORYLATION	459622	KRANGNNsPSLSNGG		activity, induced; protein stabilization; protein conformation				7638	1	0	0		
SSTR2	GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR	P30680		Sstr2		rat	T359	PHOSPHORYLATION	12577700	ETTETQRtLLNGDLQ		receptor internalization, altered				12558717	4	0	0		
LRRK2	EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, Ser/Thr (non-receptor); Protein kinase, TKL	Q5S007	120892	LRRK2	12q12	human	S2032	PHOSPHORYLATION	3306338	CRMGIKTsEGTPGFR	Pkinase	enzymatic activity, induced				15022711	3	2	0		
Huntingtin	Cytoskeletal protein	P42858	3064	HTT	4p16.3	human	S16	PHOSPHORYLATION	12056100	KAFESLKsFQQQQQQ		molecular association, regulation; intracellular localization		exportin 1(DISRUPTS)		27519631	8	0	0	nuclear exclusion	
nNOS	Amino Acid Metabolism - arginine and proline; EC 1.14.13.39; Oxidoreductase	P29476	24598	Nos1		rat	S741	PHOSPHORYLATION	452159	LAEAVKFsAKLMGQA		enzymatic activity, inhibited				4079	1	0	0		
STAT5B	DNA binding protein; Transcription factor	P51692	6777	STAT5B	17q11.2	human	Y725	PHOSPHORYLATION	448734	AGGGSATyMDQAPSP			transcription, induced			9052	2	0	1		
RACK1	Adaptor/scaffold; G protein; G protein, heterotrimeric; G protein, heterotrimeric beta WD; Motility/polarity/chemotaxis; Nuclear receptor co-regulator	P63244	10399	GNB2L1	5q35.3	human	Y246	PHOSPHORYLATION	451481	LCFSPNRyWLCAATG	WD40	molecular association, regulation; activity, inhibited; phosphorylation	cell motility, altered; transcription, inhibited	Src(INDUCES); Src(NOT_REPORTED)		8132; 3664; 11807	6	1	1		
PARK2	EC 6.3.2.-; EC 6.3.2.19; Ligase; UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase	O60260	5071	PARK2	6q25.2-q27	human	S65	PHOSPHORYLATION	25538008	NCDLDQQsIVHIVQR	ubiquitin	enzymatic activity, induced				25347059	4	1	0		
FANCE	DNA repair	Q9HB96	2178	FANCE	6p22-p21	human	T346	PHOSPHORYLATION	476781	LGLLRLCtWLLALSP	FA_FANCE	protein degradation; molecular association, regulation; intracellular localization		FANCD2(INDUCES)		9371	2	0	0	required for mitomycin C resistance	
PAP-alpha	EC 2.7.7.19; RNA processing; RNA splicing; Transferase	Q61183	18789	Papola		mouse	S537	PHOSPHORYLATION	1737605	DNSMSVPsPTSAMKT		enzymatic activity, induced				1713137	1	1	0	in vitro and in vivo	
ITGAL	Cell adhesion; Cell surface; Membrane protein, integral; Motility/polarity/chemotaxis	P20701	3683	ITGAL	16p11.2	human	S1165	PHOSPHORYLATION	2887600	LHEKDSEsGGGKD__			cell adhesion, altered			8580	1	1	0		
Cdc37	Chaperone	Q63692	114562	Cdc37		rat	S13	PHOSPHORYLATION	450034	VWDHIEVsDDEDETH	CDC37_N	molecular association, regulation; intracellular localization		ICK(INDUCES); MOK(INDUCES); Src(INDUCES); MAK(INDUCES); CDK4(INDUCES); Akt1(INDUCES); RAF1(INDUCES); AurB(INDUCES)		970033; 3754	5	8	0	S13 phosphorylated Cdc37 colocalized with HSP90 in membrane ruffles and is associated with HSP90 kinase complexes.	
NRF2	DNA binding protein; Transcription factor	Q16236	4780	NFE2L2	2q31	human	S577	PHOSPHORYLATION	10292702	DEDGKPYsPSEYSLQ		intracellular localization	transcription, induced			9983602	1	1	0	moderate effects observed only in NFE2L2-5A mutant	
Bim	Apoptosis	O88498	64547	Bcl2l11		rat	S109	PHOSPHORYLATION	449069	APMSCDKsTQTPSPP			apoptosis, induced			2106	1	0	0		
PPAR-alpha	DNA binding protein; Nuclear receptor	P37230	25747	Ppara		rat	S110	PHOSPHORYLATION	457547	RICGDKAsGYHYGVH	zf-C4	activity, induced	transcription, altered			7128	1	0	0		
MARCKS	Actin binding protein; Motility/polarity/chemotaxis	P26645	17118	Marcks		mouse	S152	PHOSPHORYLATION	447786	KKKKKRFsFKKSFKL	MARCKS	intracellular localization	carcinogenesis, induced; cell motility, altered			15027801	23	8	14		
GIT1	GTPase activating protein, ARF; Motility/polarity/chemotaxis	Q9Y2X7	28964	GIT1	17p11.2	human	S46	PHOSPHORYLATION	25784901	RSLGRHIsIVKHLRH	ArfGap	intracellular localization	cell motility, induced; cell adhesion, induced			25712631	1	1	0		
ACP1	Cofactor and Vitamin Metabolism - riboflavin; EC 3.1.3.2; EC 3.1.3.48; Motility/polarity/chemotaxis; PHOSPHATASE; Phosphatase (non-protein); Protein phosphatase, tyrosine (non-receptor)	Q3SZ94	280977	ACP1		cow	Y132	PHOSPHORYLATION	450718	QLIIEDPyYGNDADF	LMWPc	enzymatic activity, induced				7083	5	10	194		
HSP20	Chaperone	P97541	192245	Hspb6		rat	S16	PHOSPHORYLATION	450706	PSWLRRAsAPLPGFS	Crystallin	molecular association, regulation	cytoskeletal reorganization	PDE4D(INDUCES)		8332; 18415115	15	17	2		
CD33	Cell adhesion; Membrane protein, integral	P20138	945	CD33	19q13.3	human	Y358	PHOSPHORYLATION	450953	SKDTSTEySEVRTQ_		molecular association, regulation		SHP-2(INDUCES)		3223	2	0	3	While tyrosine phosphorylation of CD33 was shown to induce its interaction in cells with SHP-1 and SHP-2, the specific contribution of Y358 phosphorylation to CD33 interaction with SHP-2 was based on in vitro binding experiments.	
Rb	Nuclear receptor co-regulator; Transcription, coactivator/corepressor; Tumor suppressor	P06400	5925	RB1	13q14.2	human	S567	PHOSPHORYLATION	450021	SLAWLSDsPLFDLIK	RB_A	protein degradation; molecular association, regulation; activity, inhibited	apoptosis, induced	MDM2(INDUCES)		7208; 18376926	4	0	0		
GCSFR	Membrane protein, integral; Receptor, cytokine	P40223	12986	Csf3r		mouse	Y753	PHOSPHORYLATION	451834	RTGDQVLyGQVLESP		activity, induced				3890	4	0	0	Receptors mutant for Y728 or Y753 could neither transduce growth-inhibitory signals nor induce the neutrophil-specific myeloperoxidase (MPO) gene.	
Dok1	Adaptor/scaffold; Motility/polarity/chemotaxis	Q99704	1796	DOK1	2p13	human	Y315	PHOSPHORYLATION	448904	CPSQDSLySDPLDST		molecular association, regulation		RASA1(INDUCES)		1352	1	17	364		
MYO6	Actin binding protein; Motility/polarity/chemotaxis; Motor protein	Q29122	397085	MYO6		pig	T406	PHOSPHORYLATION	449089	TAGGAKGtVIKVPLK	Myosin_head		cytoskeletal reorganization			9043	3	7	1	T406E mutant clusters vesicles and alters F-actin (increase of filaments and bundled).  Motor moves laterally in cell instead of inward.  No change in velocity.	
FCP1	EC 3.1.3.16; Motility/polarity/chemotaxis; PHOSPHATASE; Protein phosphatase, Ser/Thr (non-receptor); Transcription initiation complex	Q9Y5B0	9150	CTDP1	18q23	human	S944	PHOSPHORYLATION	455467	NEDEGSSsEADEMAK	FCP1_C	molecular association, regulation	transcription, altered	GTF2F1(INDUCES)		6829233; 5226	2	0	1		
PPP1R14A	Inhibitor protein; Protein phosphatase, regulatory subunit	BAA22995	397610	PPP1R14A		pig	T38	PHOSPHORYLATION	449098	QKRHARVtVKYDRRE	PP1_inhibitor	activity, induced; protein conformation				3433209; 6437	26	0	0		
CRMP-2	Microtubule binding protein; Motility/polarity/chemotaxis	P47942	25416	Dpysl2		rat	T555	PHOSPHORYLATION	448084	DNIPRRTtQRIVAPP		activity, inhibited				7868	8	0	8	phosphorylation inhibits microtubule assembly and neurite outgrowth	
JAK3	EC 2.7.10.2; KINASE; Kinase, protein; Protein kinase, TK; Protein kinase, tyrosine (non-receptor)	P52333	3718	JAK3	19p13.1	human	Y980	PHOSPHORYLATION	447636	LLPLDKDyYVVREPG	Pkinase_Tyr	enzymatic activity, induced				1142	3	4	3		
dynactin 6	Motility/polarity/chemotaxis	O00399	10671	DCTN6	8p12-p11	human	T186	PHOSPHORYLATION	27933603	KTMKGSStPVKN___		molecular association, regulation; intracellular localization	cell cycle regulation	PLK1(INDUCES)		27902317	1	0	0	Dynactin 6 targets PLK1 to mitotic kinetochores.	
CDCP1	Cell surface; Membrane protein, integral	Q9H5V8	64866	CDCP1	3p21.31	human	Y762	PHOSPHORYLATION	455577	LQPEVDTyRPFQGTM		molecular association, regulation		PKCD(INDUCES)		5517	2	1	2		
HDAC2	DEACETYLASE; Deacetylase; EC 3.5.1.98; Nuclear receptor co-regulator; Transcription, coactivator/corepressor	Q92769	3066	HDAC2	6q21	human	S424	PHOSPHORYLATION	467980	CDEEFSDsEDEGEGG		acetylation; molecular association, regulation; enzymatic activity, inhibited		p53(INDUCES); HDAC1(INDUCES); KLF4(DISRUPTS)		7663506; 13354700	3	35	35		
FOXO1A	DNA binding protein; Nuclear receptor co-regulator; Transcription factor	Q12778	2308	FOXO1	13q14.1	human	K222	ACETYLATION	15625101	HNLSLHSkFIRVQNE	Fork_head	intracellular localization; phosphorylation				15022750	1	0	0		
IRS1	Adaptor/scaffold; Motility/polarity/chemotaxis	P35570	25467	Irs1		rat	Y1222	PHOSPHORYLATION	448699	SSEDLSTyASINFQK		molecular association, regulation		SHP-2(INDUCES)		7397638	2	1	0		
SLC14A2	Membrane protein, integral; Membrane protein, multi-pass; Transporter	NP_062220	54302	Slc14a2		rat	S486	PHOSPHORYLATION	2813501	TVFPRRKsVFHIEWS		activity, induced; molecular association, regulation; intracellular localization		SNAPIN(INDUCES)		2807221; 14058632; 22723948; 12558725	8	3	3		
Kv7.2	Channel, potassium; Membrane protein, integral; Membrane protein, multi-pass	O43526	3785	KCNQ2	20q13.3	human	S52	PHOSPHORYLATION	12526300	SEAPKRGsILSKPRA		activity, induced				12482211	1	2	2		
hnRNP A1	RNA binding protein; RNA splicing; Spliceosome	P09651	3178	HNRNPA1	12q13.1	human	S199	PHOSPHORYLATION	451555	SQRGRSGsGNFGGGR		activity, inhibited				2831754	4	5	3		
p300	ACETYLTRANSFERASE; Acetyltransferase; EC 2.3.1.48; Motility/polarity/chemotaxis; Nuclear receptor co-regulator; Transcription, coactivator/corepressor	Q09472	2033	EP300	22q13.2	human	S2366	PHOSPHORYLATION	486264	MEQGHFAsPDQNSML		molecular association, regulation; enzymatic activity, induced	transcription, altered	SP1(NOT_REPORTED)		12065	2	0	0	 controls EGF-induced keratin 16 promoter activity ; regulates HAT activity of p300	
CARD11	Adaptor/scaffold	Q5F3W0	416476	RCJMB04_5k17		chicken	S578	PHOSPHORYLATION	457640	NRNDSIMsTTPEPPG		molecular association, regulation		Bcl-10(INDUCES); MALT1(INDUCES)		1713142	2	0	0		
4E-BP1	Translation; Translation initiation	Q13541	1978	EIF4EBP1	8p12	human	T50	PHOSPHORYLATION	3195728	FSTTPGGtRIIYDRK	eIF_4EBP	phosphorylation	cell growth, induced; translation, induced	eIF4E(DISRUPTS)		28854800; 29676408	2	14	38	T41 and T50 act as priming sites for T37/46; T41A and T50A  mutants inhibited tumor growth and showed more cap-binding.	
CCND3	Activator protein; Cell cycle regulation; Nuclear receptor co-regulator	P30281	896	CCND3	6p21	human	T283	PHOSPHORYLATION	452160	QGPSQTStPTDVTAI		protein degradation				4081; 7389; 4621	5	2	6	mutation (T283A) prevents its degradation induced by forskolin, but has no effect on okadaic acid-induced degradation.	
SIRT1	Apoptosis; DEACETYLASE; Deacetylase; EC 3.5.1.-; Nuclear receptor co-regulator	Q96EB6	23411	SIRT1	10q21.3	human	S27	PHOSPHORYLATION	452898	ADREAASsPAGEPLR		intracellular localization; enzymatic activity, induced				12021300	2	7	1		
Akt1	EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor)	P31749	207	AKT1	14q32.32	human	S246	PHOSPHORYLATION	460649	LSRERVFsEDRARFY	Pkinase	enzymatic activity, induced	apoptosis, inhibited			7752	1	0	0	doxorubicin-induced apoptosis	
HMGB1	DNA repair; Nuclear receptor co-regulator	P09429	3146	HMGB1	13q12	human	S35	PHOSPHORYLATION	476055	KKKHPDAsVNFSEFS	Nop14; DUF1898; Nucleo_P87	intracellular localization	cell motility, altered			9201014	2	11	3	increases tumor cell invasiveness	
MEF2C	DNA binding protein; Transcription factor	Q8CFN5	17260	Mef2c		mouse	S396	PHOSPHORYLATION	456980	SIKSEPVsPPRDRTT		molecular association, regulation		Pin1(INDUCES)		15235218	3	4	0	Pin1 binding decreases MEF2C stability and its transcriptional activity	
RXRA	DNA binding protein; Motility/polarity/chemotaxis; Nuclear receptor	P19793	6256	RXRA	9q34.3	human	S32	PHOSPHORYLATION	456811	RGSMAAPsLHPSLGP	Nuc_recep-AF1	molecular association, regulation; activity, inhibited	transcription, inhibited	SRC-1(DISRUPTS)		14081213; 6871	2	0	0		
TXA2-R iso2	GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR	P21731-2	6915	TBXA2R	19p13.3	human	S357	PHOSPHORYLATION	469629	RLPGSSDsRASASRA		molecular association, regulation; receptor desensitization, altered; receptor internalization, altered		ARRB2(INDUCES)		8248	1	0	0		
ECT2	Guanine nucleotide exchange factor, Rac/Rho; Motility/polarity/chemotaxis	Q9H8V3	1894	ECT2	3q26.1-q26.2	human	T444	PHOSPHORYLATION	457522	TKSSKSStPVPSKQS		activity, induced; molecular association, regulation	transcription, altered	PLK1(INDUCES)		6982	2	1	7	phosphorylation important for RhoA activation	
RPS10	Ribosomal protein; Translation	P46783	6204	RPS10	6p21.31	human	R160	METHYLATION	13906403	RGGFGRGrGQPPQ__		protein stabilization; molecular association, regulation; intracellular localization		NPM1(INDUCES)		13326311	1	0	0	 localization in the granular component (GC) region of the nucleolus; efficient assembly of RPS10 into ribosomes and protein synthesis	
p47phox	EC 1.-.-.-; Oxidoreductase	P14598	653361	NCF1	7q11.23	human	S304	PHOSPHORYLATION	449406	GAPPRRSsIRNAHSI		activity, induced; molecular association, regulation; intracellular localization; enzymatic activity, induced		CYBA(INDUCES)		2208; 17335000; 8704	8	0	0		
HPK1	EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, STE; Protein kinase, Ser/Thr (non-receptor)	Q92918	11184	MAP4K1	19q13.1-q13.4	human	T175	PHOSPHORYLATION	4198300	RRLSFIGtPYWMAPE	Pkinase	enzymatic activity, induced	transcription, altered			5232	2	1	2		
AQP1	Membrane protein, integral; Membrane protein, multi-pass; Transporter	P29972	358	AQP1	7p14	human	T239	PHOSPHORYLATION	482807	APRSSDLtDRVKVWT	DUF805	activity, induced				11752	2	0	0	phosphorylation by PKC increases ion currents and water permability of AQP1.	
BRCA1	EC 6.3.2.-; Nuclear receptor co-regulator; Transcription, coactivator/corepressor; Tumor suppressor; UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase	P38398	672	BRCA1	17q21	human	S1189	PHOSPHORYLATION	450007	QKGELSRsPSPFTHT		molecular association, regulation; intracellular localization		ATM(INDUCES)		1757; 9980402	4	5	6	promotes formation of BRCA1 foci	
NFkB-p105	DNA binding protein; Transcription factor	P19838	4790	NFKB1	4q24	human	S328	PHOSPHORYLATION	22771100	INITKPAsVFVQLRR		molecular association, regulation	transcription, inhibited		DNA(DISRUPTS)	22723921; 27257052	2	0	0		
VCP	Chaperone; DNA repair; Endoplasmic reticulum; Hydrolase	P55072	7415	VCP	9p13.3	human	S748	PHOSPHORYLATION	457558	RFARRSVsDNDIRKY	DNA_ligase_A_C; Vps4_C		apoptosis, inhibited			7785	2	5	1		
FOXO1A	DNA binding protein; Nuclear receptor co-regulator; Transcription factor	Q12778	2308	FOXO1	13q14.1	human	S418	PHOSPHORYLATION	478369	NTSLNSPsPNYQKYT		intracellular localization	transcription, altered			12525214	4	0	0	multiple site mutant (8A)	
KCNK9	Membrane protein, integral; Membrane protein, multi-pass	Q9NPC2	51305	KCNK9	8q24.3	human	S373	PHOSPHORYLATION	18609100	RLMKRRKsV______		activity, induced; intracellular localization				18410857	1	0	0		
NPHS1	Cell adhesion; Immunoglobulin superfamily; Membrane protein, integral	Q9R044	64563	Nphs1		rat	Y1204	PHOSPHORYLATION	469565	PGAWGPLyDEVRMDP		molecular association, regulation; phosphorylation	cytoskeletal reorganization	Nck1(NOT_REPORTED); PLCE1(INDUCES)		8285; 6331322; 2195700	10	1	0		
Jun	Transcription factor	P17325	24516	Jun		rat	S63	PHOSPHORYLATION	447686	KNSDLLTsPDVGLLK	Jun	activity, induced; protein stabilization	transcription, altered; cell growth, altered			1676; 4914020	101	19	4		
Snail1	C2H2-type zinc finger protein; Transcription factor	O95863	6615	SNAI1	20q13.2	human	S107	PHOSPHORYLATION	455882	SQPPSPPsPAPSSFS	CAP_N	activity, induced; protein degradation; ubiquitination; intracellular localization	cell motility, altered; transcription, altered			11419352; 6066701; 6098000; 6376; 15031342	5	0	0		
IRF4	DNA binding protein; Transcription factor	Q64287	16364	Irf4		mouse	S447	PHOSPHORYLATION	12265165	HRSLRHSsIQE____			cell differentiation, induced; transcription, induced		DNA(INDUCES)	25779413	1	1	0	production of IL-17 and IL-21 	
CYP1A1	Amino Acid Metabolism - tryptophan; Cofactor and Vitamin Metabolism - retinol; EC 1.14.14.1; Oxidoreductase; Xenobiotic Metabolism - metabolism by cytochrome P450	P00184	13076	Cyp1a1		mouse	T35	PHOSPHORYLATION	471065	WVVRATRtWVPKGLK		intracellular localization				9045	1	0	0	regulates CYP1A1 mitochondrial trafficking	
IKKB	EC 2.7.11.10; KINASE; Kinase, protein; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor)	O88351	16150	Ikbkb		mouse	S697	PHOSPHORYLATION	17934903	QPSSACDsLPESDKK		molecular association, regulation; phosphorylation		PPP2R3C(INDUCES)		17675011	1	0	0	interaction with PPP2R3C (aka G4-1) downregulates IKK-beta activity;  S181 phosphorylation increased in S679/682/689/692/697/701/705A mutant	
C/EBP-beta	DNA binding protein; Motility/polarity/chemotaxis; Transcription factor	P21272	24253	Cebpb		rat	S64	PHOSPHORYLATION	456166	HERAIDFsPYLEPLA			transcription, induced; cell growth, altered			8351; 11475	7	0	1		
restin	Cytoskeletal protein	Q9JK25	65201	Rsn		rat	S1246	PHOSPHORYLATION	3189736	EDPNSYDsDDQEKQS		molecular association, regulation		dynactin 1(INDUCES)		15022731	2	5	0		
K20	Cytoskeletal protein	P35900	54474	KRT20	17q21.2	human	S13	PHOSPHORYLATION	463823	RSFHRSLsSSLQAPV			apoptosis, induced			7844	3	5	0	promotes keratin filaments disassembly	
ENaC-alpha	Channel, sodium; Membrane protein, integral; Membrane protein, multi-pass	P37089	25122	Scnn1a		rat	S621	PHOSPHORYLATION	454020	RFRSRYWsPGRGARG		activity, induced; intracellular localization				4162; 18021014	3	0	0		
Drosha	EC 3.1.26.3; RNA binding protein; RNA processing; Ribonuclease	Q9NRR4	29102	DROSHA	5p13.3	human	S300	PHOSPHORYLATION	14572630	RHRDNRRsPSLERSY		intracellular localization				14780518; 20540215	2	8	0	nuclear localization	
ADCY6	Adenylyl cyclase; EC 4.6.1.1; Lyase; Membrane protein, integral; Membrane protein, multi-pass; Nucleotide Metabolism - purine	AAA40678	25289	Adcy6		rat	S568	PHOSPHORYLATION	455528	TFLILGAsQKRKEEK		enzymatic activity, inhibited				3690	1	0	0		
SREBP-1	DNA binding protein; Membrane protein, integral; Membrane protein, multi-pass; Transcription factor	P36956	6720	SREBF1	17p11.2	human	S117	PHOSPHORYLATION	469986	YPSMPAFsPGPGIKE			transcription, induced; transcription, altered			17482919; 8826	4	3	0	regulation of lipid metabolism by GH	
RAC1	G protein; G protein, monomeric, Rho; Motility/polarity/chemotaxis	P63000	5879	RAC1	7p22	human	S71	PHOSPHORYLATION	447994	YDRLRPLsYPQTDVF	Ras	activity, inhibited				769	3	2	6	Phosphorylation of this site inhibits  GTP binding activity of Rac1 without affecting its GTPase activity.	
TREK-1	Channel, potassium; Membrane protein, integral; Membrane protein, multi-pass	P97438	16526	Kcnk2		mouse	S333	PHOSPHORYLATION	456161	KETRRRLsVEIYDKF		activity, induced; activity, inhibited	cytoskeletal reorganization			1968303; 8863; 8156700; 8862; 6614	7	3	0		
PKD2	EC 2.7.11.13; KINASE; Kinase, protein; Motility/polarity/chemotaxis; Protein kinase, CAMK; Protein kinase, Ser/Thr (non-receptor)	Q9BZL6	25865	PRKD2	19q13.3	human	S710	PHOSPHORYLATION	449865	GEKSFRRsVVGTPAY	Pkinase	enzymatic activity, induced				1963	4	15	34		
KIF2C	Cancer Testis Antigen (CTA); Microtubule binding protein; Motility/polarity/chemotaxis; Motor protein	Q91636	380006	kif2c		frog	S196	PHOSPHORYLATION	2132102	NNQGRRKsNIVKEME		molecular association, regulation; intracellular localization; activity, inhibited	cytoskeletal reorganization		DNA(DISRUPTS)	3361009; 3309528	5	1	25		
MSK2	EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor)	O75676	8986	RPS6KA4	11q11-q13	human	S343	PHOSPHORYLATION	450045	TRLEPVYsPPGSPPP	Pkinase_C	enzymatic activity, induced				1264	1	16	4		
P70S6KB	EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor); Translation	Q9UBS0	6199	RPS6KB2	11q13.2	human	S423	PHOSPHORYLATION	455991	SSPRAPVsPLKFSPF		enzymatic activity, induced				6518	2	7	35		
IKK-gamma	Adaptor/scaffold; Protein kinase, regulatory subunit	Q9Y6K9	8517	IKBKG	Xq28	human	S85	PHOSPHORYLATION	458399	ELLHFQAsQREEKEF	NEMO	molecular association, regulation; intracellular localization	transcription, altered	ATM(INDUCES)		7474	4	0	0		
CA9	EC 4.2.1.1; Energy Metabolism - nitrogen; Lyase; Membrane protein, integral	Q16790	768	CA9	9p13.3	human	T443	PHOSPHORYLATION	21691604	RRQHRRGtKGGVSYR		enzymatic activity, induced	cell motility, induced			21683702	1	0	0		
Src	EC 2.7.10.2; KINASE; Kinase, protein; Protein kinase, TK; Protein kinase, tyrosine (non-receptor)	Q9WUD9	83805	Src		rat	Y419	PHOSPHORYLATION	448234	RLIEDNEyTARQGAK	Pkinase_Tyr	molecular association, regulation; enzymatic activity, induced	translation, altered; cell adhesion, altered	ILK(INDUCES)		15235238; 4313624; 4214817; 5189	267	61	3059	Induces fibronectin expression and deposition and increases AngII mesangial cell hypertrophy	
DNAM-1	Cell adhesion; Immunoglobulin superfamily; Membrane protein, integral	Q15762	10666	CD226	18q22.3	human	S329	PHOSPHORYLATION	450987	YVNYPTFsRRPKTRV	RCR	activity, induced; molecular association, regulation				5207; 3250	2	0	0	S329 phosphorylation is critical for DNAM-1 adhesion.; Wild type, but not S329 mutant, DNAM-1 associated with lipid rafts in the forming immunological synapse. 	
DAP3	Apoptosis; Mitochondrial; Nuclear receptor co-regulator	P51398	7818	DAP3	1q22	human	S252	PHOSPHORYLATION	2226200	KELKRQSsLGMFHLL	DAP3		apoptosis, induced			2195711	1	1	0		
GIT1	GTPase activating protein, ARF; Motility/polarity/chemotaxis	Q9Y2X7	28964	GIT1	17p11.2	human	Y383	PHOSPHORYLATION	481671	DLDDQHDyDSVASDE		intracellular localization	cell motility, altered; cytoskeletal reorganization			15278819	4	10	175	 important for podosome formation and PLC gamma activation	
PPP1R3A	Membrane protein, integral; Protein phosphatase, regulatory subunit	Q16821	5506	PPP1R3A	7q31.1	human	S65	PHOSPHORYLATION	449321	SSGTRRVsFADSFGF		molecular association, regulation		PPP1CA(DISRUPTS)		8752	5	2	0	Association transiently lost after insulin treatment. 	
TIE2	EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Protein kinase, TK; Protein kinase, tyrosine (receptor)	Q02763	7010	TEK	9p21	human	Y1102	PHOSPHORYLATION	450256	MLEERKTyVNTTLYE		molecular association, regulation; enzymatic activity, induced	cell adhesion, altered	Shc1(NOT_REPORTED)		15755110; 2958	5	0	0		
doublecortin	Cytoskeletal protein; Motility/polarity/chemotaxis	O43602	1641	DCX	Xq22.3-q23	human	S128	PHOSPHORYLATION	451112	TRTLQALsNEKKAKK		molecular association, regulation	cytoskeletal reorganization	TUBA1B(DISRUPTS); ACTA1(INDUCES)		5214	3	0	0		
Ago2	EC 3.1.26.n2; RNA processing	Q9UKV8	27161	EIF2C2	8q24	human	Y393	PHOSPHORYLATION	17533102	ASFNTDPyVREFGIM		molecular association, regulation	apoptosis, inhibited	Dicer1(DISRUPTS); TRBP(DISRUPTS)		30280002	2	1	0	inhibits miRNA processing from precursor miRNAs to mature miRNA, EGFR-enhanced cell survival and invasiveness under hypoxia	
MELK	EC 2.7.10.2; EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, CAMK; Protein kinase, Ser/Thr (non-receptor); RNA splicing	Q14680	9833	MELK	9p13.2	human	T478	PHOSPHORYLATION	451160	RNQCLKEtPIKIPVN		molecular association, regulation	translation, altered	NIPP-1(INDUCES)		3350	1	3	4	regulates translation = spliceosome assembly	
HIF1A	Autophagy; DNA binding protein; Transcription factor	Q16665	3091	HIF1A	14q23.2	human	S657	PHOSPHORYLATION	17331802	ETTSATSsPYRDTQS		protein degradation				17299800	1	1	0		
PARP1	DNA repair; EC 2.4.2.30; Nuclear envelope; Nuclear receptor co-regulator; Transferase	P09874	142	PARP1	1q41-q42	human	T373	PHOSPHORYLATION	463805	AATPPPStASAPAAV		enzymatic activity, induced				7837	1	1	0		
MRCKA	EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor)	Q5VT25	8476	CDC42BPA	1q42.11	human	T240	PHOSPHORYLATION	12612501	QSSVAVGtPDYISPE	Pkinase	enzymatic activity, induced	cytoskeletal reorganization			12482237	1	0	0		
PAR3-alpha	Adaptor/scaffold; Motility/polarity/chemotaxis	Q9Z340	81918	Pard3		rat	S827	PHOSPHORYLATION	467266	REGFGRQsMSEKRTK		molecular association, regulation	cytoskeletal reorganization	PKCZ(DISRUPTS)		8718	3	1	0	cell polarity	
PKCE	EC 2.7.11.13; KINASE; Kinase, protein; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor)	P16054	18754	Prkce		mouse	S350	PHOSPHORYLATION	486055	RSKSAPTsPCDQELK	DUF1631		cell cycle regulation			3301203	1	8	0		
Rb	Nuclear receptor co-regulator; Transcription, coactivator/corepressor; Tumor suppressor	P06400	5925	RB1	13q14.2	human	K873	ACETYLATION	459026	SNPPKPLkKLRFDIE	Rb_C	molecular association, regulation; intracellular localization; phosphorylation	cell cycle regulation	E2F1(DISRUPTS)		7499; 7635	3	0	0	reduced level of CDK-dependent phosphorylation of Rb KK873/874QQ mutant; alters the distribution of Rb in the nucleus	
VANGL2	Adaptor/scaffold; Membrane protein, integral; Membrane protein, multi-pass	Q91ZD4	93840	Vangl2		mouse	S84	PHOSPHORYLATION	18460401	GTSEHSIsHDDLTRI	Strabismus	activity, induced; protein stabilization				18410837	1	0	0		
WAVE1	Cytoskeletal protein; Motility/polarity/chemotaxis	Q8R5H6	83767	Wasf1		mouse	S310	PHOSPHORYLATION	4764996	LIENRPQsPAAGRTP		activity, inhibited				14081210	3	6	0		
p27Kip1	Cell cycle regulation; Inhibitor protein; Protein kinase, regulatory subunit	P46527	1027	CDKN1B	12p13.1-p12	human	T187	PHOSPHORYLATION	447875	NAGSVEQtPKKPGLR		protein degradation; protein stabilization; molecular association, regulation; ubiquitination; protein conformation	cell cycle regulation	SKP2(INDUCES); CCND1(INDUCES); SKP1A(INDUCES); CDK2(DISRUPTS); CKS1(INDUCES); CUL1(INDUCES); CDK4(INDUCES); Pin1(INDUCES)		4966810; 3256111; 9938501; 7613711; 2582608; 1173036; 9306; 6271; 1205; 4971000; 5994; 6011128; 2135	38	0	0		
ECT2	Guanine nucleotide exchange factor, Rac/Rho; Motility/polarity/chemotaxis	Q9H8V3	1894	ECT2	3q26.1-q26.2	human	T359	PHOSPHORYLATION	483847	YLYEKANtPELKKSV		molecular association, regulation; intracellular localization	carcinogenesis, altered; cell growth, altered			17675037	1	8	4	 regulates association with PKCI-Par6 complex; activates Rac1	
PAM	EC 1.14.17.3; EC 4.3.2.5; Lyase; Membrane protein, integral; Oxidoreductase; Vesicle protein	P14925	25508	Pam		rat	S937	PHOSPHORYLATION	450813	FASRKGYsRKGFDRV		protein stabilization; intracellular localization				3143	1	0	0	Phosphorylation of PAM-1 at S937 directs newly synthesized and internalized protein away from lysosomes	
SLP76	Adaptor/scaffold	Q13094	3937	LCP2	5q35.1	human	Y128	PHOSPHORYLATION	448219	DGEDDGDyESPNEEE		molecular association, regulation; phosphorylation	cytoskeletal reorganization; transcription, induced	ITK(INDUCES); Nck1(INDUCES); VAV1(INDUCES); PIK3R1(INDUCES)		5955628; 25725911; 2630609; 2943; 4730	17	0	0		
HCN4	Channel, cation; Membrane protein, integral; Membrane protein, multi-pass	O70507	330953	Hcn4		mouse	S1139	PHOSPHORYLATION	15103400	VTLPRKTsSGSLPPP		activity, induced				15022705	1	0	0	required for PKA to shift the voltage dependence of HCN4	
C/EBP-beta	DNA binding protein; Motility/polarity/chemotaxis; Transcription factor	Q05826		CEBPB		chicken	K39	METHYLATION	16825100	DCLAALNkLHPRAAG			transcription, altered			16823900	1	0	0		
BAD	Apoptosis	Q61337	12015	Bad		mouse	S128	PHOSPHORYLATION	447861	EGMEEELsPFRGRSR	Bcl-2_BAD	molecular association, regulation	apoptosis, induced	14-3-3 zeta(DISRUPTS)		6384; 6070	7	6	19		
IRS1	Adaptor/scaffold; Motility/polarity/chemotaxis	P35569	16367	Irs1		mouse	S632	PHOSPHORYLATION	447506	NGDYMPMsPKSVSAP		molecular association, regulation		PIK3C2A(DISRUPTS)		4032	32	12	1		
TrkB	EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Protein kinase, TK; Protein kinase, tyrosine (receptor)	Q63604	25054	Ntrk2		rat	Y705	PHOSPHORYLATION	448811	RDVYSTDyYRVGGHT	Pkinase_Tyr	molecular association, regulation; enzymatic activity, induced	translation, altered; transcription, altered	Shc1(INDUCES); PLCG1(INDUCES); SH2D1A(INDUCES)		7398; 3980; 10199100	9	1	52	c-fos protein synthesis induced by BDNF	
CAMK2A	EC 2.7.11.17; KINASE; Kinase, protein; Protein kinase, CAMK; Protein kinase, Ser/Thr (non-receptor)	P11275	25400	Camk2a		rat	T253	PHOSPHORYLATION	451571	DLINKMLtINPSKRI	Pkinase	intracellular localization				8162	6	6	0	increases binding of CaMK2-alpha to subcellular fractions enriched in postsynaptic densities (PSD)	
CARD11	Adaptor/scaffold	Q9BXL7	84433	CARD11	7p22	human	S558	PHOSPHORYLATION	4737145	MQPPRSRsSIMSITA		activity, induced				9980428	1	1	0	important for HPK1-mediated and TCR-mediated activation of NFkB-p65	
CCKBR	GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR	P32239	887	CCKBR	11p15.4	human	T439	PHOSPHORYLATION	6057804	SLSRLSYtTISTLGP		molecular association, regulation		ARRB1(INDUCES); RGS2(INDUCES)		17675032; 5930020	2	0	0		
GRB14	Adaptor/scaffold	Q14449	2888	GRB14	2q22-q24	human	S372	PHOSPHORYLATION	7611001	ISPMRSIsENSLVAM	BPS	molecular association, regulation	cell cycle regulation; cell growth, altered	InsR(INDUCES)		7549217	1	5	0	modulates the Grb14 inhibitory effect on insulin signaling	
SYT6	Membrane protein, integral; Vesicle protein	Q5T7P8	148281	SYT6	1p13.2	human	T283	PHOSPHORYLATION	456501	DRKCKLQtRVHRKTL	C2	activity, induced				6712	1	0	0		
PLSCR1	Calcium-binding protein; Membrane protein, integral	O15162	5359	PLSCR1	3q23	human	T161	PHOSPHORYLATION	11380906	CGPSRPFtLRIIDNM	Scramblase	activity, induced				10292903	1	0	0		
ARHGAP22	GTPase activating protein, Rac/Rho	Q7Z5H3	58504	ARHGAP22	10q11.22	human	S16	PHOSPHORYLATION	22262003	ARRARSKsLVMGEQS		molecular association, regulation	cell motility, induced	14-3-3 beta(INDUCES)		21683726	1	2	0		
Grb10	Adaptor/scaffold	Q60760	14783	Grb10		mouse	S501	PHOSPHORYLATION	4727990	TRMNILSsQSPLHPS		protein stabilization				19044701	1	3	1		
H1R	GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR	P35367	3269	HRH1	3p25	human	T478	PHOSPHORYLATION	453403	CNENFKKtFKRILHI		receptor desensitization, altered				4121	1	0	0		
AMPKB1	Autophagy; Protein kinase, regulatory subunit	Q9Y478	5564	PRKAB1	12q24.1-q24.3	human	S108	PHOSPHORYLATION	448522	SKLPLTRsHNNFVAI	CBM_48	activity, induced; molecular association, regulation; phosphorylation				27141511; 2852674	8	35	2	activates AMPK1 and phosphorylation of T174; S108 mutation abolishes protective effect of salicylate and A-769662 binding, on T172 dephosphorylation.	
CENPJ	Cell cycle regulation; Microtubule binding protein; Transcription, coactivator/corepressor	Q9HC77	55835	CENPJ	13q12.12	human	S589	PHOSPHORYLATION	14918202	EQAADEIsFSSNSSF			cell cycle regulation			14780531	1	0	0	required for centriole elongation	
Rad9	Apoptosis; Cell cycle regulation; DNA replication; Deoxyribonuclease; EC 3.1.11.2	Q99638	5883	RAD9A	11q13.1-q13.2	human	S328	PHOSPHORYLATION	449812	VLPSISLsPGPQPPK		molecular association, regulation; intracellular localization	cell cycle regulation; apoptosis, induced; chromatin organization, altered	TLK1(INDUCES)		26341767; 13354725; 8762; 6829221	6	3	7	translocated from the nucleus to the mitochondria during etoposide induced-apoptosis (Rad9 mediated apoptosis)	
LIP8	Cell cycle regulation	Q8N137	116840	CNTROB	17p13.1	human	T35	PHOSPHORYLATION	27565612	NQVSSEVtSQLYASL			cell motility, inhibited			27565307	1	0	0		
AT2	GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR	P35351	24182	Agtr2		rat	S354	PHOSPHORYLATION	469106	MSCRKSSsLREMDTF		activity, induced	cell growth, altered			8304	1	0	0		
Wee1	EC 2.7.10.2; KINASE; Kinase, protein; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor)	P30291	7465	WEE1	11p15.3-p15.1	human	S123	PHOSPHORYLATION	451132	EEGFGSSsPVKSPAA		protein degradation; molecular association, regulation; phosphorylation		BTRC(INDUCES); PLK1(INDUCES); FBW1B(INDUCES)		3333; 6704	3	0	0		
NFkB-p105	DNA binding protein; Transcription factor	P19838	4790	NFKB1	4q24	human	S903	PHOSPHORYLATION	455617	KTTSQAHsLPLSPAS		protein stabilization				5662	1	6	15		
ChREBP	Transcription factor	Q8VIP2	171078	Mlxipl		rat	T666	PHOSPHORYLATION	458376	KMENRRItHISAEQK	DUF3584; HLH	intracellular localization	transcription, altered			3592	2	0	0	inhibits the DNA-binding activity of ChREBP	
doublecortin iso2	Cytoskeletal protein; Motility/polarity/chemotaxis	O43602-2	1641	DCX	Xq22.3-q23	human	T331	PHOSPHORYLATION	469976	SKQSPIStPTSPGSL		intracellular localization	cell motility, altered; cytoskeletal reorganization			8909	1	1	2	affects doublecortin localization to growth cones, neurite outgrowth, and neuronal motility	
SEC14L2	Lipid binding protein	O76054	23541	SEC14L2	22q12.2	human	S289	PHOSPHORYLATION	455526	VQISRGSsHQVEYEI	GOLD_2	activity, induced				5224	1	0	0		
IkB-alpha	DNA binding protein; Inhibitor protein	P25963	4792	NFKBIA	14q13	human	Y305	PHOSPHORYLATION	448799	FTEDELPyDDCVFGG		protein degradation				5644	2	0	3		
C/EBP-alpha	DNA binding protein; Transcription factor	P49715	1050	CEBPA	19q13.1	human	S21	PHOSPHORYLATION	448308	PMSSHLQsPPHAPSS		activity, induced; molecular association, regulation; protein conformation; activity, inhibited	cell differentiation, altered; transcription, inhibited; transcription, altered		DNA(DISRUPTS)	1903013; 2403302; 4555; 13270506	7	0	0		
NMDAR1	Channel, calcium; Channel, ligand-gated; Membrane protein, integral; Membrane protein, multi-pass	P35439	24408	Grin1		rat	S896	PHOSPHORYLATION	448255	SSFKRRRsSKDTSTG		molecular association, regulation		calmodulin(DISRUPTS)		1706	20	0	0		
AR	DNA binding protein; Nuclear receptor; Transcription factor	P10275	367	AR	Xq12	human	S424	PHOSPHORYLATION	449807	AAGPGSGsPSAAASS	Androgen_recep		transcription, altered			8049	3	1	0		
CFTR	Channel, chloride; EC 3.6.3.49; Hydrolase; Membrane protein, integral; Membrane protein, multi-pass; Transporter	P13569	1080	CFTR	7q31.2	human	T604	PHOSPHORYLATION	2907506	NKTRILVtSKMEHLK		activity, induced				8384; 8371	2	0	1		
E2A	DNA binding protein; Transcription factor	P15923	6929	TCF3	19p13.3	human	S359	PHOSPHORYLATION	465682	SPSTPVGsPQGLAGT		activity, inhibited	transcription, inhibited			10353939	2	4	25		
SPTA1	Cytoskeletal protein; Motility/polarity/chemotaxis	P02549	6708	SPTA1	1q21	human	Y548	PHOSPHORYLATION	13421404	KLIGDDHyDSENIKA	Spectrin		cytoskeletal reorganization			13359104	1	1	0		
occludin	Cell adhesion; Membrane protein, integral; Membrane protein, multi-pass; Motility/polarity/chemotaxis	Q16625	100506658	OCLN	5q13.1	human	T404	PHOSPHORYLATION	471472	HYETDYTtGGESCDE	DUF342; APG6	intracellular localization				5926301	4	5	5		
CYLD	EC 3.1.2.15; EC 3.4.19.12; Protease; Ubiquitin conjugating system; Ubiquitin-specific protease	Q9NQC7	1540	CYLD	16q12.1	human	S441	PHOSPHORYLATION	12173908	GHSPLSLsAQSVMEE		ubiquitination				12156302	1	0	0	induces ubiquitination of TRAF2	
EGFR	EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Protein kinase, TK; Protein kinase, tyrosine (receptor)	P00533	1956	EGFR	7p12	human	S1190	PHOSPHORYLATION	451819	PNGIFKGsTAENAEY		receptor internalization, altered				3881	1	0	4		
Rad9	Apoptosis; Cell cycle regulation; DNA replication; Deoxyribonuclease; EC 3.1.11.2	Q99638	5883	RAD9A	11q13.1-q13.2	human	S277	PHOSPHORYLATION	449811	SHSQDLGsPERHQPV		phosphorylation	cell cycle regulation			13354725; 8762	4	9	3		
SMPD3	EC 3.1.4.12; Lipid Metabolism - sphingolipid; Membrane protein, integral; Phospholipase	Q9JJY3	58994	Smpd3		mouse	S173	PHOSPHORYLATION	17547983	QIKIYIDsPTNTSIS		enzymatic activity, induced				22463914	1	2	0		
INCENP	Cell cycle regulation; EC 2.7.11.1	Q9NQS7	3619	INCENP	11q12.3	human	S894	PHOSPHORYLATION	450468	RYHKRTSsAVWNSPP		activity, induced				3012	4	15	25		
CDT1	DNA binding protein; DNA replication; Motility/polarity/chemotaxis	Q9H211	81620	CDT1	16q24.3	human	T29	PHOSPHORYLATION	455584	PPKLACRtPSPARPA		molecular association, regulation	cell cycle regulation; transcription, inhibited	SKP2(INDUCES)		22568300; 5531	2	6	1	Cdt1 protein is degraded in S phase even in T29A mutant (even though it no longer co-IPs with Skp2).  Overexpression of WT Cdt1 induced rereplication (DNA content >4N) and this was even greater in the T29A mutant.; T29 phosphorylation impairs HBO1 binding at replication origins in response to stress, inhibiting transcription.	
MKP-3	EC 3.1.3.16; EC 3.1.3.48; Motility/polarity/chemotaxis; Protein phosphatase, dual-specificity	Q9DBB1	67603	Dusp6		mouse	S159	PHOSPHORYLATION	455265	DGSCSSSsPPLPVLG		protein degradation	signaling pathway regulation			26349400	4	0	0	represses expression of gluconeogenic genes and glucose output	
ITGB4	Cell adhesion; Membrane protein, integral; Motility/polarity/chemotaxis; Receptor, misc.	P16144	3691	ITGB4	17q25	human	S1360	PHOSPHORYLATION	451654	VLRSPSGsQRPSVSD		molecular association, regulation		plectin 1(DISRUPTS)		12087	4	0	4		
rhodopsin	GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR	P02699	509933	RHO		cow	S343	PHOSPHORYLATION	448680	TVSKTETsQVAPA__		molecular association, regulation; protein conformation		SAG(INDUCES)		3621	3	5	0	Computational and in vitro data. S343 may be a weaker interaction.	
RSK2	EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor)	P18654	110651	Rps6ka3		mouse	S227	PHOSPHORYLATION	448063	DHEKKAYsFCGTVEY	Pkinase	enzymatic activity, induced				12025503; 1263	8	21	132		
p16-INK4A	Cell cycle regulation	P42771	1029	CDKN2A	9p21	human	S140	PHOSPHORYLATION	448831	AAGGTRGsNHARIDA	Ank_2	protein stabilization; molecular association, regulation		CDK4(INDUCES)		18119108	3	0	0		
GRK2	EC 2.7.11.15; KINASE; Kinase, protein; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor)	P25098	156	ADRBK1	11q13.1	human	Y13	PHOSPHORYLATION	456872	AVLADVSyLMAMEKS		protein degradation; molecular association, regulation		G-alpha(q)(INDUCES)		8002; 8017	5	0	0		
AurA	EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor)	O14965	6790	AURKA	20q13	human	T287	PHOSPHORYLATION	457654	HAPSSRRtTLCGTLD	Pkinase	enzymatic activity, inhibited; enzymatic activity, induced				4500; 28722427	4	4	1		
CRMP-2	Microtubule binding protein; Motility/polarity/chemotaxis	P47942	25416	Dpysl2		rat	S522	PHOSPHORYLATION	448082	PASSAKTsPAKQQAP			cell growth, altered			4252	13	19	84		
Jun	Transcription factor	P05627	16476	Jun		mouse	T91	PHOSPHORYLATION	450448	SNGHITTtPTPTQFL	Jun	molecular association, regulation		NPM1(INDUCES); p14ARF(INDUCES)		4215301	7	0	0		
VEGFR2	EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Protein kinase, TK; Protein kinase, tyrosine (receptor)	P35918	16542	Kdr		mouse	Y1006	PHOSPHORYLATION	455661	TLEHLICySFQVAKG	Pkinase_Tyr	molecular association, regulation	cell growth, altered	PLCG1(INDUCES)		5817	1	0	0		
Dok1	Adaptor/scaffold; Motility/polarity/chemotaxis	Q99704	1796	DOK1	2p13	human	Y449	PHOSPHORYLATION	448879	KSHNSALySQVQKSG		molecular association, regulation		CD45(INDUCES); SH2D1A(INDUCES)		8708; 7910503	3	28	1065		
PPP1CC	EC 3.1.3.16; Motility/polarity/chemotaxis; PHOSPHATASE; Protein phosphatase, Ser/Thr (non-receptor)	P36873	5501	PPP1CC	12q24.1-q24.2	human	T307	PHOSPHORYLATION	3190033	EKKKPNAtRPVTPPR		enzymatic activity, inhibited				10296915	1	3	3	in vitro	
NKCC1	Membrane protein, integral; Membrane protein, multi-pass; Transporter	P55011	6558	SLC12A2	5q23.3	human	T230	PHOSPHORYLATION	459123	RIDHYRHtAAQLGEK	AA_permease_N	activity, induced				8682	3	4	3		
CTNNA1	Actin binding protein; Motility/polarity/chemotaxis	P35221	1495	CTNNA1	5q31.2	human	S641	PHOSPHORYLATION	449139	TPEELDDsDFETEDF	Vinculin	molecular association, regulation	carcinogenesis, induced; cell motility, altered; transcription, altered	CTNNB1(DISRUPTS)		14511600	2	57	65	S641 phosphorylation promotes Beta-catenin transactivation and tumor cell invasion.	
NIPA	Cell cycle regulation; Ubiquitin conjugating system	Q86WB0	51530	ZC3HC1	7q32.2	human	S354	PHOSPHORYLATION	449745	PIVSRTRsWDSSSPV		molecular association, regulation	cell cycle regulation; apoptosis, altered	SKP1A(DISRUPTS)		11952; 6664; 2140	4	19	31		
PXN iso2	Adaptor/scaffold; Cell adhesion; Cytoskeletal protein; Motility/polarity/chemotaxis	P49023-2	5829	PXN	12q24.31	human	S130	PHOSPHORYLATION	450228	KQKSAEPsPTVMSTS	Paxillin		cell cycle regulation; carcinogenesis, altered; transcription, altered			15022718	5	14	4	regulates Erk1/2-induced cell proliferation and transcription	
hnRNP A1	RNA binding protein; RNA splicing; Spliceosome	P04256	29578	Hnrnpa1		rat	S199	PHOSPHORYLATION	451555	SQRGRSGsGNFGGGR		activity, inhibited				2852618	4	5	3		
MEK1	EC 2.7.12.2; KINASE; Kinase, protein; Protein kinase, STE; Protein kinase, dual-specificity	P29678	100009316	MAP2K1		rabbit	S222	PHOSPHORYLATION	448513	LIDSMANsFVGTRSY	Pkinase	enzymatic activity, induced				894	85	9	183	in vitro	
p300	ACETYLTRANSFERASE; Acetyltransferase; EC 2.3.1.48; Motility/polarity/chemotaxis; Nuclear receptor co-regulator; Transcription, coactivator/corepressor	Q09472	2033	EP300	22q13.2	human	S2315	PHOSPHORYLATION	486263	RSPQPVPsPRPQSQP		molecular association, regulation; enzymatic activity, induced	transcription, altered	SP1(NOT_REPORTED)		12065	2	4	1	 controls EGF-induced keratin 16 promoter activity ; regulates HAT activity of p300	
PLCG2	Carbohydrate Metabolism - inositol phosphate; EC 3.1.4.11; Motility/polarity/chemotaxis; Phospholipase	P24135	29337	Plcg2		rat	Y1217	PHOSPHORYLATION	447939	LNNQLFLyDTHQNLR		enzymatic activity, induced				2451	7	10	356		
RAF1	EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, Ser/Thr (non-receptor); Protein kinase, TKL	P04049	5894	RAF1	3p25	human	S339	PHOSPHORYLATION	447743	PRGQRDSsYYWEIEA		molecular association, regulation; intracellular localization; enzymatic activity, induced		Bcl-2(INDUCES); MEK1(INDUCES)		2512; 8397; 5121525; 6528; 6072	8	1	1		
PKACA	EC 2.7.11.11; KINASE; Kinase, protein; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor)	P05132	18747	Prkaca		mouse	T198	PHOSPHORYLATION	448459	RVKGRTWtLCGTPEY	Pkinase	protein stabilization; protein conformation; phosphorylation; enzymatic activity, induced				2694; 1236; 12662606; 4829206	20	27	258		
H3	DNA binding protein	P68431	8350	HIST1H3A	6p22.1	human	Y42	PHOSPHORYLATION	10897613	GVKKPHRyRPGTVAL		molecular association, regulation	chromatin organization, altered	HP1 alpha(DISRUPTS)		10901000	2	2	2		
DAPK1	Apoptosis; Autophagy; EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, CAMK; Protein kinase, Ser/Thr (non-receptor)	P53355	1612	DAPK1	9q21.33	human	S308	PHOSPHORYLATION	448142	ARKKWKQsVRLISLC		protein degradation; molecular association, regulation; enzymatic activity, inhibited	apoptosis, altered; cell adhesion, altered; cell growth, altered	CHIP(DISRUPTS); MIB1(DISRUPTS); calmodulin(DISRUPTS)		6555; 14146310; 1173032	7	1	0		
caveolin-1	Adaptor/scaffold; Motility/polarity/chemotaxis; Nuclear receptor co-regulator	Q03135	857	CAV1	7q31.1	human	Y14	PHOSPHORYLATION	448422	VDSEGHLyTVPIREQ		activity, induced; molecular association, regulation; intracellular localization; phosphorylation	cell cycle regulation; apoptosis, induced; cell motility, altered; cell adhesion, altered; cytoskeletal reorganization; transcription, altered; cell growth, altered	CSK(INDUCES); GRB7(INDUCES); TRAF2(INDUCES); MMP9(INDUCES)		5768; 6271029; 6076; 2626200; 5867; 4650413; 4553; 4207601; 4650414; 1910512	35	28	794		
MLK3	EC 2.7.11.25; KINASE; Kinase, protein; Protein kinase, Ser/Thr (non-receptor); Protein kinase, TKL	Q16584	4296	MAP3K11	11q13.1-q13.3	human	S281	PHOSPHORYLATION	448262	WHKTTQMsAAGTYAW	Pkinase_Tyr	molecular association, regulation; enzymatic activity, induced		GEFT(INDUCES)		717; 7124734	6	0	0	p-MLK3 regulates levels of activated GEFT	
MST3	EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, STE; Protein kinase, Ser/Thr (non-receptor)	Q9Y6E0	8428	STK24	13q31.2-q32.3	human	T190	PHOSPHORYLATION	468211	DTQIKRNtFVGTPFW	Pkinase	enzymatic activity, induced	cell motility, altered			9180	2	16	103		
p53	Activator protein; DNA binding protein; Motility/polarity/chemotaxis; Nuclear receptor co-regulator; Transcription factor; Tumor suppressor	P02340	22059	Tp53		mouse	K367	UBIQUITINATION	464659	SSYLKTKkGQSTSRH			transcription, altered			3141407	11	0	0	p53K6R (K378/383/369/379/367/370/R) mutant is still ubiquitinated and shows normal stability of p53 before and after DNA damage	
RBM4	RNA binding protein; RNA splicing	Q9BWF3	5936	RBM4	11q13	human	S309	PHOSPHORYLATION	476783	SYYGRDRsPLRRATA		molecular association, regulation; intracellular localization	translation, induced	eIF4A1(INDUCES); Ago2(DISRUPTS)		28723101; 9362	2	4	0		
BKR2	GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR	P25023	25245	Bdkrb2		rat	T167	PHOSPHORYLATION	457435	RYLALVKtMSMGRMR	7tm_1	receptor desensitization, altered; receptor internalization, altered; activity, inhibited				8309; 7063	2	0	0	Phosphorylation reduces signaling through arachidonic acid release and phosphoinositde turnover, and increase receptor internalization.	
CACNA1D	Channel, calcium; Membrane protein, integral; Membrane protein, multi-pass	P27732	29716	Cacna1d		rat	S1743	PHOSPHORYLATION	6062700	VNSDRREsLQQTNTT		activity, induced				5930025	2	0	0		
Casp9	Apoptosis; EC 3.4.22.62; Protease	Q9R0T0	12371	Casp9		mouse	T163	PHOSPHORYLATION	449563	PEVLRPEtPRPVDIG		enzymatic activity, inhibited	apoptosis, altered			6842231	6	1	4		
SH3BP2	Adaptor/scaffold	Q06649	24055	Sh3bp2		mouse	Y183	PHOSPHORYLATION	449092	HEDEDDSyLEPDSPG		molecular association, regulation		PLCG2(INDUCES); VAV1(INDUCES)		11189912	3	0	0	positively regulates 3BP2-mediated transcriptional activation of NFAT  	
SLC22A1	Membrane protein, integral; Membrane protein, multi-pass; Transporter	Q63089	24904	Slc22a1		rat	T296	PHOSPHORYLATION	455612	WLLSQKRtTRAVRIM	Sugar_tr	activity, induced				5524	1	0	0	stimulates ASP+ uptake	
NFAT1	DNA binding protein; Transcription factor	Q60591	18019	Nfatc2		mouse	S54	PHOSPHORYLATION	455326	IAHKAISsPSGLAYP			transcription, induced			1188	0	1	0		
TLK1	EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor)	Q9UKI8-2	9874	TLK1	2q31.1	human	S764	PHOSPHORYLATION	449050	PHMRRSNsSGNLHMA		enzymatic activity, inhibited				2088	2	1	0		
FGFR1	EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Protein kinase, TK; Protein kinase, tyrosine (receptor)	P11362	2260	FGFR1	8p12	human	Y654	PHOSPHORYLATION	447919	DIHHIDYyKKTTNGR	Pkinase_Tyr	phosphorylation; enzymatic activity, induced	cell differentiation, altered; cell motility, altered; cell growth, altered			675; 1962905	8	10	174	Double Y->F mutant has less neurite outgrowth in PC12 cells (differentiation), and less cell proliferation in L-6 cells.; Data collected by isolating phosphorylated species in vitro and confirming their phosphorylation states by mass spec. Y->F mutations were also done but unpublished.	
Myb	DNA binding protein; Transcription factor	P06876	17863	Myb		mouse	T354	PHOSPHORYLATION	1308924	CLGEHHAtPSLPADP		protein degradation				1172847	1	0	0	stress-induced degredation	
RXRA	DNA binding protein; Motility/polarity/chemotaxis; Nuclear receptor	P19793	6256	RXRA	9q34.3	human	S260	PHOSPHORYLATION	450891	NMGLNPSsPNDPVTN	Hormone_recep	protein stabilization; intracellular localization; activity, inhibited	transcription, inhibited; transcription, altered			8791; 14081213; 5894; 3164; 7739	8	0	0		
RASSF1 iso2	Tumor suppressor	Q9NS23-2	11186	RASSF1	3p21.3	human	S179	PHOSPHORYLATION	13258706	RPVSVPSsKKPPSLQ		molecular association, regulation	apoptosis, inhibited	TRAIL-R1(DISRUPTS); 14-3-3 zeta(INDUCES); 14-3-3 epsilon(INDUCES); TNF-R1(DISRUPTS); MOAP1(DISRUPTS)		13159408	1	0	0		
ASK1	EC 2.7.11.25; KINASE; Kinase, protein; Protein kinase, STE; Protein kinase, Ser/Thr (non-receptor)	O35099	26408	Map3k5		mouse	T845	PHOSPHORYLATION	448394	GINPCTEtFTGTLQY	Pkinase	molecular association, regulation; enzymatic activity, induced	apoptosis, induced; transcription, induced	MKK3(INDUCES)		25353000; 12482411	13	1	1	AP-1 transcriptional activity	
GRK2	EC 2.7.11.15; KINASE; Kinase, protein; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor)	P21146	282682	ADRBK1		cow	S685	PHOSPHORYLATION	447726	VPLIQRGsANGL___		molecular association, regulation		ADRB2(INDUCES)		1108	2	4	1		
Lamin B2	Cytoskeletal protein; Motility/polarity/chemotaxis	P14732		LMNB2		chicken	S411	PHOSPHORYLATION	20657001	STSLVRSsRGKRRRI		intracellular localization				20656300	1	0	0	nuclear uptake inhibited in vitro	
FBX43	Unknown function	Q4G163	286151	FBXO43	8q22.2	human	S334	PHOSPHORYLATION	12581001	SISTPEDsGFNSLSL		protein degradation; ubiquitination				12482299	1	0	0		
HDAC5	EC 3.5.1.98; Hydrolase	Q9UQL6	10014	HDAC5	17q21	human	S498	PHOSPHORYLATION	447996	RPLSRTQsSPLPQSP		molecular association, regulation; enzymatic activity, inhibited; intracellular localization	cell differentiation, altered; chromatin organization, altered; cell motility, altered; transcription, induced; transcription, altered	PKD1(DISRUPTS); HDAC3(DISRUPTS); 14-3-3 epsilon(INDUCES); TBL1X(DISRUPTS); TBL1XR1(DISRUPTS); PKD3(DISRUPTS); GPS2(DISRUPTS); 14-3-3 beta(INDUCES); SMRT(DISRUPTS); PKD2(DISRUPTS); N-CoR1(INDUCES)		17431525; 7397634; 3735502; 2581; 7119503	18	3	4	required for VEGF-induced nuclear export, transcription of MEF2 and in vitro angiogenesis	
ABCC9	Channel, potassium; Membrane protein, integral; Membrane protein, multi-pass; Transporter	P70170	20928	Abcc9		mouse	T633	PHOSPHORYLATION	483974	FESCKKHtGVQSKPI		activity, induced				8597	2	0	0		
MKK7	EC 2.7.12.2; KINASE; Kinase, protein; Protein kinase, STE; Protein kinase, dual-specificity	O14733	5609	MAP2K7	19p13.3-p13.2	human	S271	PHOSPHORYLATION	447697	ISGRLVDsKAKTRSA	Pkinase	enzymatic activity, induced	transcription, altered			3278	2	1	0		
Brk	EC 2.7.10.2; KINASE; Kinase, protein; Protein kinase, TK; Protein kinase, tyrosine (non-receptor)	Q13882	5753	PTK6	20q13.3	human	Y447	PHOSPHORYLATION	450276	RLSSFTSyENPT___		molecular association, regulation; enzymatic activity, inhibited		Akt1(DISRUPTS)		4301; 2985; 2983	5	9	379		
mTOR	Autophagy; EC 2.7.11.1; KINASE; Kinase, protein; Motility/polarity/chemotaxis; Protein kinase, ATYPICAL; Protein kinase, Ser/Thr (non-receptor)	P42345	2475	MTOR	1p36.2	human	S2481	PHOSPHORYLATION	447498	TVPESIHsFIGDGLV		enzymatic activity, induced				682; 14146316; 5820	37	13	1		
SREBP-1	DNA binding protein; Membrane protein, integral; Membrane protein, multi-pass; Transcription factor	P36956	6720	SREBF1	17p11.2	human	S430	PHOSPHORYLATION	467201	DTLTPPPsDAGSPFQ		protein degradation; molecular association, regulation; phosphorylation	transcription, induced	FBXW7(INDUCES)		6331305; 8159	2	0	0		
Syk	EC 2.7.10.2; KINASE; Kinase, protein; Protein kinase, TK; Protein kinase, tyrosine (non-receptor)	Q64725	25155	Syk		rat	Y624	PHOSPHORYLATION	459326	ELRLRNYyYDVVN__		molecular association, regulation; phosphorylation; enzymatic activity, induced		FcER1G(INDUCES)		14780510	1	0	6	; mutation of this site stimulates phosphorylation of Y317, Y519 and Y520;  required for activation of ERK1/2 and p38MAP kinases;  required for activation of NFAT and NFkB	
ICAP1	Cell adhesion; Motility/polarity/chemotaxis	O14713	9270	ITGB1BP1	2p25.2	human	T38	PHOSPHORYLATION	450887	GGLSRSStVASLDTD	ICAP-1_inte_bdg	activity, inhibited	cell adhesion, altered			3174	1	3	0	A T38D mutation is defective in cell spreading, while a T38A mutation stimulates cell spreading.	
JNK1	EC 2.7.11.24; KINASE; Kinase, protein; Protein kinase, CMGC; Protein kinase, Ser/Thr (non-receptor)	Q91Y86	26419	Mapk8		mouse	T183	PHOSPHORYLATION	447643	AGTSFMMtPYVVTRY	Pkinase	protein degradation; molecular association, regulation	transcription, altered	GSK3B(INDUCES); CTNNB1(INDUCES)		6804603	201	19	370	degredation of beta-catenin.	
PLCB1	Carbohydrate Metabolism - inositol phosphate; EC 3.1.4.11; Phospholipase	Q9NQ66	23236	PLCB1	20p12	human	S982	PHOSPHORYLATION	4787475	KKKSEPSsPDHGSST		enzymatic activity, induced				7309811	1	2	0	S982 critical in IGF mediated activation of nuclear PI cycle 	
AFAP	Adaptor/scaffold	Q8N556	60312	AFAP1	4p16	human	Y453	PHOSPHORYLATION	3891002	PEALHYDyIDVEMSA		molecular association, regulation		Src(INDUCES)		4664	1	0	0	Src Y529F Src mutant	
Grb10	Adaptor/scaffold	Q13322	2887	GRB10	7p12.2	human	Y67	PHOSPHORYLATION	448348	NASLESLySACSMQS		molecular association, regulation		InsR(DISRUPTS)		1344	1	0	1		
MAP2	Cytoskeletal protein; Motility/polarity/chemotaxis	P11137	4133	MAP2	2q34-q35	human	S1710	PHOSPHORYLATION	456809	HVTSKCGsLKNIRHR	Tubulin-binding	molecular association, regulation; intracellular localization	cytoskeletal reorganization	TUBA1A(INDUCES); ACTB(INDUCES)		7324105	2	1	0		
PILRA	Membrane protein, integral; Receptor, misc.	Q9UKJ1	29992	PILRA	7q22.1	human	Y269	PHOSPHORYLATION	3141902	PKDDGIVyASLALSS		molecular association, regulation		SHP-1(INDUCES)		8731	1	0	0		
NFAT4	DNA binding protein; Transcription factor	Q12968	4775	NFATC3	16q22.2	human	S211	PHOSPHORYLATION	11507600	TLGSPLTsPGGSPGG		intracellular localization				10274612	1	0	1	cytoplasmic localization (inhibition of nuclear localization)	
FAK iso3	EC 2.7.1.112; EC 2.7.10.2; KINASE; Kinase, protein; Protein kinase, TK; Protein kinase, tyrosine (non-receptor)	P34152-3	14083	Ptk2		mouse	Y577	PHOSPHORYLATION	447890	YMEDSTYyKASKGKL	Pkinase_Tyr	activity, induced; molecular association, regulation	cell adhesion, altered	P130Cas(INDUCES)		2864; 2886; 1698	64	29	1766		
Arg	EC 2.7.10.2; KINASE; Kinase, protein; Protein kinase, TK; Protein kinase, tyrosine (non-receptor)	P42684	27	ABL2	1q25.2	human	Y261	PHOSPHORYLATION	455657	GLVTTLHyPAPKCNK		protein stabilization; ubiquitination				5567	1	0	0		
EphB1	EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Protein kinase, TK; Protein kinase, tyrosine (receptor)	P54762	2047	EPHB1	3q21-q23	human	Y928	PHOSPHORYLATION	3053617	SAIKMVQyRDSFLTA	SAM_1	molecular association, regulation; phosphorylation	cell motility, altered	GRB7(INDUCES)		8537	2	0	0	phosphorylation of Grb7	
FcRL6	Membrane protein, integral	Q6DN72	343413	FCRL6	1q23.2	human	Y371	PHOSPHORYLATION	12523300	GKDEGVVySVVHRTS		molecular association, regulation		SHP-2(INDUCES)		12482407	1	0	0		
IRF7	DNA binding protein; Transcription factor	P70434	54123	Irf7		mouse	S441	PHOSPHORYLATION	1276100	LCLSSTNsLYEDIEH			transcription, induced		DNA(INDUCES)	12173	2	0	0		
Bcr	EC 2.7.11.1; GTPase activating protein, Rac/Rho; KINASE; Kinase, protein; Protein kinase, ATYPICAL; Protein kinase, Ser/Thr (non-receptor)	P11274	613	BCR	22q11.23	human	Y360	PHOSPHORYLATION	447796	VSPSPTTyRMFRDKS		phosphorylation; enzymatic activity, induced				1749; 1744	4	1	29		
CTMP		Q5T1C6	117145	THEM4	1q21	human	S38	PHOSPHORYLATION	9721502	PELRSFSsEEVILKD		intracellular localization				9689409	1	1	0		
Rb	Nuclear receptor co-regulator; Transcription, coactivator/corepressor; Tumor suppressor	P33568	24708	Rb1		rat	S772	PHOSPHORYLATION	447978	STRPPTLsPIPHIPR	Rb_C	molecular association, regulation		HDAC1(INDUCES)		7119507	56	9	112		
FASN	ACETYLTRANSFERASE; Acetyltransferase; EC 1.1.1.100; EC 1.3.1.10; EC 2.3.1.38; EC 2.3.1.39; EC 2.3.1.41; EC 2.3.1.85; EC 3.1.2.14; EC 4.2.1.61; Hydrolase; Lipid Metabolism - fatty acid biosynthesis; Lyase; Oxidoreductase	P49327	2194	FASN	17q25	human	T1032	PHOSPHORYLATION	27930801	NWVSFMDtMLQMSIL			transcription, inhibited			27902335	1	1	0		
ABCA1	Membrane protein, integral; Membrane protein, multi-pass; Transporter; Vesicle protein	O95477	19	ABCA1	9q31.1	human	Y1206	PHOSPHORYLATION	3718336	DIGHELTyVLPYEAA		activity, inhibited				18415117	1	0	0		
CACNA1C	Channel, calcium; Membrane protein, integral; Membrane protein, multi-pass	Q01815	12288	Cacna1c		mouse	S783	PHOSPHORYLATION	457631	KKLARTAsPEKKQEV		activity, inhibited		STX1A(DISRUPTS); SNAP-25(DISRUPTS)		7265	1	0	0		
PPAR-gamma iso2	DNA binding protein; Nuclear receptor	P37238-2	19016	Pparg		mouse	S21	PHOSPHORYLATION	12170301	GISSVDLsVMEDHSH	PPARgamma_N	intracellular localization	transcription, altered			12021331	1	0	0		
GFAP	Cytoskeletal protein	P14136	2670	GFAP	17q21	human	T7	PHOSPHORYLATION	449617	_MERRRItSAARRSY	Filament_head	protein stabilization				2254	6	0	0		
MST2	Autophagy; EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, STE; Protein kinase, Ser/Thr (non-receptor)	Q13188	6788	STK3	8q22.2	human	Y81	PHOSPHORYLATION	25528501	MQQCDSPyVVKYYGS	Pkinase	molecular association, regulation; enzymatic activity, induced		MST2(INDUCES); RAF1(DISRUPTS)		25347035	1	1	0		
Akt2	EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor)	P31751	208	AKT2	19q13.1-q13.2	human	T309	PHOSPHORYLATION	448537	SDGATMKtFCGTPEY	Pkinase	intracellular localization; enzymatic activity, induced				1738	9	1	13		
Smad3	DNA binding protein; Nuclear receptor co-regulator; Transcription factor	P84022	4088	SMAD3	15q22.33	human	S208	PHOSPHORYLATION	451179	DAGSPNLsPNPMSPA		intracellular localization; activity, inhibited	transcription, inhibited; transcription, altered; cell growth, altered			5262; 6945; 15658700; 3386	11	0	0		
Kv4.3	Channel, potassium; Membrane protein, integral; Membrane protein, multi-pass	Q62897	65195	Kcnd3		rat	S569	PHOSPHORYLATION	455338	LPATRLRsMQELSTI		activity, inhibited				3309527	2	2	2		
hnRNP L	RNA binding protein; RNA splicing	P14866	3191	HNRNPL	19q13.2	human	S544	PHOSPHORYLATION	15436636	GKSERSSsGLLEWES		molecular association, regulation			RNA(NOT_REPORTED)	25347025	1	2	0		
p53	Activator protein; DNA binding protein; Motility/polarity/chemotaxis; Nuclear receptor co-regulator; Transcription factor; Tumor suppressor	P04637	7157	TP53	17p13.1	human	K372	UBIQUITINATION	464660	HSSHLKSkKGQSTSR		protein degradation; intracellular localization	transcription, inhibited			12136; 7920	11	0	0	K370/372/373/381/382/386/R mutant shows 613-fold activation of p53	
NUP98 iso2	Motility/polarity/chemotaxis; Nucleoporin	P52948-2	4928	NUP98	11p15.5	human	T529	PHOSPHORYLATION	3149520	AAQKALTtPTHYKLT		intracellular localization				18331300	1	5	8	as multiple sites (13PM) mutant 	
CAMK2A	EC 2.7.11.17; KINASE; Kinase, protein; Protein kinase, CAMK; Protein kinase, Ser/Thr (non-receptor)	P11798	12322	Camk2a		mouse	T286	PHOSPHORYLATION	447797	SCMHRQEtVDCLKKF		molecular association, regulation; intracellular localization; protein conformation; phosphorylation; enzymatic activity, induced	cell growth, altered	NMDAR1(INDUCES); calmodulin(INDUCES)		4650407; 5727; 25185202; 5354414; 4313610; 14081218; 19016938; 6842220	100	21	55	LTP requires autophosphorylated T286; Autophosphorylation deficient T286A mutant mouse with training, induced PSD95 upregulation, generated multiinervated spines and required mTOR signaling contributing to LTM.	
NEDD4L	EC 6.3.2.-; EC 6.3.2.19; Ligase; UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase	Q96PU5	23327	NEDD4L	18q21	human	T367	PHOSPHORYLATION	453439	AGRARSStVTGGEEP		phosphorylation		ENaC-alpha(INDUCES)		4138	3	1	15	Phosphorylation of NEDD4L  by PKA inhibits binding to ENaC. 	
IGF1R	EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Protein kinase, TK; Protein kinase, tyrosine (receptor)	NP_999337	397350	IGF1R		pig	Y1161	PHOSPHORYLATION	448386	FGMTRDIyETDYYRK	Pkinase_Tyr	activity, induced				4683	16	19	453		
NFAT1	DNA binding protein; Transcription factor	Q60591	18019	Nfatc2		mouse	S170	PHOSPHORYLATION	449624	YREPLCLsPASSGSS		activity, induced	transcription, induced; transcription, inhibited			1188; 5803	2	1	0		
CIITA	DNA binding protein; Transcription, coactivator/corepressor	P33076	4261	CIITA	16p13	human	S834	PHOSPHORYLATION	448443	QELPGRLsFLGTRLT			transcription, altered			1462	1	0	0		
CK1A	EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, CK1; Protein kinase, Ser/Thr (non-receptor)	P48729	1452	CSNK1A1	5q32	human	S218	PHOSPHORYLATION	11333100	LMYFNRTsLPWQGLK	Pkinase	molecular association, regulation		14-3-3 eta(INDUCES)		11270022	1	0	0		
Mer	EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Protein kinase, TK; Protein kinase, tyrosine (receptor)	Q12866	10461	MERTK	2q14.1	human	Y749	PHOSPHORYLATION	449988	FGLSKKIySGDYYRQ	Pkinase_Tyr	enzymatic activity, induced				2539	1	9	442		
Dok2	Adaptor/scaffold	O70469	13449	Dok2		mouse	Y351	PHOSPHORYLATION	447615	APLPDHIyDEPEGVA		molecular association, regulation	cell differentiation, altered; cell growth, altered	Nck1(NOT_REPORTED); Nck1(INDUCES)		5379; 7309801; 4091; 2305; 1400	5	0	25		
TrkA	EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Protein kinase, TK; Protein kinase, tyrosine (receptor)	P04629	4914	NTRK1	1q21-q22	human	Y701	PHOSPHORYLATION	2035400	MPPESILyRKFTTES	Pkinase_Tyr	protein stabilization; molecular association, regulation; receptor internalization, altered; protein processing; enzymatic activity, inhibited; phosphorylation	cell differentiation, altered; cell growth, altered	LAMP1(INDUCES); CLTC(INDUCES)		1968318	1	0	1	Y701D mutation inhibits receptor autophosphorylation in vivo, but not in vitro	
MYBPC3	Myosin binding protein	O70468	17868	Mybpc3		mouse	S282	PHOSPHORYLATION	471080	AGAGRRTsDSHEDAG		molecular association, regulation	apoptosis, altered; cytoskeletal reorganization	MYBPC1(DISRUPTS)		9008	17	6	24	The triple aspartic acid mutation shows greater distance between the two thick myosin filaments (affects the steric arrangement of the filament distances) in heart tissue.  Mutation is cardioprotective during stress (ischemia-reprofusion injury) against apoptosis similar to isoproterenol treatment.	
5-LO	EC 1.13.11.34; Lipid Metabolism - arachidonic acid; Lipid Metabolism - linoleic acid; Nuclear envelope; Oxidoreductase	P09917	240	ALOX5	10q11.2	human	S664	PHOSPHORYLATION	461913	QLPYYYLsPDRIPNS	Lipoxygenase	enzymatic activity, induced				4616701	2	0	0	resistance to certain 5-LO inhibitors	
VEGFR2	EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Protein kinase, TK; Protein kinase, tyrosine (receptor)	P35968	3791	KDR	4q11-q12	human	Y951	PHOSPHORYLATION	447903	RFRQGKDyVGAIPVD	Pkinase_Tyr	activity, induced; molecular association, regulation; receptor internalization, altered; phosphorylation; enzymatic activity, induced	cell motility, altered	PLCG1(INDUCES)		2325; 6313; 2512009	12	1	3		
E2A iso2	DNA binding protein; Transcription factor	P15923-2	6929	TCF3	19p13.3	human	S352	PHOSPHORYLATION	465681	SSNNFSSsPSTPVGS		molecular association, regulation	transcription, induced	NEUROD1(INDUCES)		8116	2	0	3		
PAR3-alpha	Adaptor/scaffold; Motility/polarity/chemotaxis	Q8TEW0	56288	PARD3	10p11.21	human	S873	PHOSPHORYLATION	3207429	VDDQKAGsPSRDVGP		molecular association, regulation		Gab1(DISRUPTS)		25712645	1	16	1		
TELO2	Adaptor/scaffold	Q9Y4R8	9894	TELO2	16p13.3	human	S487	PHOSPHORYLATION	15668105	AQLAGSDsDLDSDDE		molecular association, regulation		PIH1D1(INDUCES)		15562522	2	0	0	this interaction (as a part of R2TP/prefoldin-like complex) is important for mTor and Smg1 stability	
PDE3B	EC 3.1.4.17; Membrane protein, integral; Membrane protein, multi-pass; Nucleotide Metabolism - purine; Phosphodiesterase	Q13370	5140	PDE3B	11p15.1	human	S318	PHOSPHORYLATION	449873	CKIFRRPsLPCISRE		molecular association, regulation; enzymatic activity, induced		14-3-3 beta(INDUCES); 14-3-3 eta(INDUCES)		9257	5	7	19		
Cdc25C	EC 3.1.3.48; Motility/polarity/chemotaxis; PHOSPHATASE; Protein phosphatase, dual-specificity	P30307	995	CDC25C	5q31	human	S214	PHOSPHORYLATION	448417	SRSGLYRsPSMPENL	M-inducer_phosp	molecular association, regulation; enzymatic activity, induced	cell cycle regulation; cell adhesion, altered	14-3-3 beta(DISRUPTS)		5485; 2459; 15031311	4	0	10	In the absence of S214 phosphorylation Cdc25C can be phosphorylated on S216 and can bind to 14-3-3 proteins in mitosis	
SF3B1	RNA binding protein; RNA splicing; Spliceosome	O75533	23451	SF3B1	2q33.1	human	T248	PHOSPHORYLATION	455542	GSETPGAtPGSKIWD	SF3b1	molecular association, regulation		NIPP-1(INDUCES)		5421	1	15	3		
Tara iso5	Actin binding protein; Cytoskeletal protein; Motility/polarity/chemotaxis	Q9H2D6-5	11078	TRIOBP	22q13.1	human	T457	PHOSPHORYLATION	27171500	QAEEREHtLRRCQQE	Spc7		cell cycle regulation			25620914	1	0	0	required for accurate chromosome segregation	
calmodulin	Calcium-binding protein	P62161	24242	Calm1		rat	T80	PHOSPHORYLATION	448704	MARKMKDtDSEEEIR	DUF2267; DUF1103; LNS2; TerB; Tenui_NCP	activity, inhibited				4213; 1876	7	2	0	accelrates SK channel deactivation; Calmodulin phosphorylated by CKII in vitro showed reduced activation of erythrocyte plasma membrane Ca2+ pump.	
HuR	RNA binding protein	Q15717	1994	ELAVL1	19p13.2	human	S221	PHOSPHORYLATION	478357	QAQRFRFsPMGVDHM		molecular association, regulation; intracellular localization; phosphorylation	translation, altered; cell motility, altered; RNA stability, altered	14-3-3 theta(INDUCES); PKCA(INDUCES)		28723110; 9614; 2195481; 12525216	7	0	0		
AS160	GTPase activating protein, Rab	O60343	9882	TBC1D4	13q22.2	human	S751	PHOSPHORYLATION	455924	EGRKRTSsTCSNESL		molecular association, regulation		14-3-3 epsilon(INDUCES)		14058615	9	6	48	multiple sites (6P) mutant	
NFkB-p65	DNA binding protein; Nuclear receptor co-regulator; Transcription factor	Q04207	19697	Rela		mouse	S276	PHOSPHORYLATION	447798	SMQLRRPsDRELSEP		activity, induced; protein degradation; acetylation; molecular association, regulation; protein processing	cell differentiation, altered; apoptosis, altered; transcription, induced; transcription, altered	HDAC3(DISRUPTS); RelB(INDUCES); p300(INDUCES); CBP(INDUCES)		4324807; 6943; 6944; 1193; 6189	62	0	0		
Oct4	DNA binding protein; Transcription factor	Q01860	5460	POU5F1	6p21.31	human	S111	PHOSPHORYLATION	25236703	ESNSDGAsPEPCTVT		protein degradation; ubiquitination; intracellular localization; activity, inhibited	transcription, altered			26341764	2	2	0	phosphorylation of this site downregulates Nanog, SOX2, REX1 and upregulates BMP4, GATA6, DDLX5 	
MARK3	EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, CAMK; Protein kinase, Ser/Thr (non-receptor)	P27448	4140	MARK3	14q32.3	human	S215	PHOSPHORYLATION	450315	KLDTFCGsPPYAAPE	Pkinase	enzymatic activity, induced				2942	2	7	10		
Mnk1	EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, CAMK; Protein kinase, Ser/Thr (non-receptor); Translation	Q9BUB5	8569	MKNK1	1p33	human	T255	PHOSPHORYLATION	447622	ITTPELTtPCGSAEY	Pkinase	enzymatic activity, induced	apoptosis, inhibited; cell growth, altered			2717400; 762706; 4313600	11	0	0	Disruption of Mnk1 Mnk2 enhances As2O4 inducedapoptosis.	
PLD1 iso2	EC 3.1.4.4; Lipid Metabolism - ether lipid; Lipid Metabolism - glycerophospholipid; Motility/polarity/chemotaxis; Phospholipase	Q13393-2	5337	PLD1	3q26	human	T147	PHOSPHORYLATION	448573	PIPTRRHtFRRQNVR	PX	intracellular localization; enzymatic activity, induced				2865425	5	0	0		
MC2R	GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR	Q64326	17200	Mc2r		mouse	S280	PHOSPHORYLATION	456325	PFIYAFRsPELRDAF		receptor desensitization, altered; activity, inhibited				6572	1	0	0		
RAF1	EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, Ser/Thr (non-receptor); Protein kinase, TKL	P04049	5894	RAF1	3p25	human	S499	PHOSPHORYLATION	450237	VKSRWSGsQQVEQPT	Pkinase_Tyr	phosphorylation; enzymatic activity, induced				8397; 2513	2	0	0		
CD84	Cell surface; Immunoglobulin superfamily; Membrane protein, integral; Motility/polarity/chemotaxis	Q9UIB8	8832	CD84	1q24	human	Y316	PHOSPHORYLATION	454841	EEPVNTVySEVQFAD		molecular association, regulation	cell growth, altered	SH2D1B(INDUCES); SH2D1B(NOT_REPORTED); Arg(NOT_REPORTED)		3033; 27932900	1	5	197		
Cbl	Adaptor/scaffold; EC 6.3.2.-; EC 6.3.2.19; Ligase; Motility/polarity/chemotaxis; UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase	P22681	867	CBL	11q23.3	human	S623	PHOSPHORYLATION	10288600	NRHSLPFsLPSQMEP		molecular association, regulation		14-3-3 eta(INDUCES)		10144203	0	0	3		
PU.1	DNA binding protein; Transcription factor	P17433	20375	Spi1		mouse	S142	PHOSPHORYLATION	451055	EEEGERQsPPLEVSD		activity, induced	transcription, induced			5742	1	0	0		
NR2C1	DNA binding protein; Nuclear receptor	Q505F1	22025	Nr2c1		mouse	T210	PHOSPHORYLATION	4206803	SPLAATPtFVTDSET		sumoylation; molecular association, regulation		HDAC3(INDUCES); PML(INDUCES)		6331324; 4042510	2	1	0	triggers NR2C1 localization to promyelocytic leukemia (PML) nuclear bodies	
Src	EC 2.7.10.2; KINASE; Kinase, protein; Protein kinase, TK; Protein kinase, tyrosine (non-receptor)	P12931	6714	SRC	20q12-q13	human	S75	PHOSPHORYLATION	450326	NSSDTVTsPQRAGPL		enzymatic activity, induced	cytoskeletal reorganization; cell growth, altered			3989	7	16	3		
HMGA1	DNA binding protein	Q8K585	117062	Hmga1		rat	T78	PHOSPHORYLATION	451516	KTRKVTTtPGRKPRG		molecular association, regulation			DNA(DISRUPTS)	8553	4	6	1		
Ret	EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Protein kinase, TK; Protein kinase, tyrosine (receptor)	P35546	19713	Ret		mouse	S697	PHOSPHORYLATION	451267	SSGTRRPsLDSTENQ		activity, induced; phosphorylation	cell motility, altered; cytoskeletal reorganization			9021	5	3	0	S697A mice show aganglionosis in the distal colon due to an impaired migration of ENCCs.  ENCCs lack chemoattraction to GDNF in culture, fewer GDNF-induced lamellipodia, and JNK activation.	
HOXA10	DNA binding protein; Transcription factor	P31260	3206	HOXA10	7p15.2	human	Y343	PHOSPHORYLATION	455550	GRKKRCPyTKHQTLE	Homeobox	molecular association, regulation; activity, inhibited	transcription, induced	HOXA10(INDUCES)		5436	1	0	0	phosphorylation decreases Hox-A10 DNA binding affinity and transcriptional repression activity.	
PECAM-1	Cell adhesion; Membrane protein, integral	P16284	5175	PECAM1	17q23.3	human	Y713	PHOSPHORYLATION	448760	KKDTETVySEVRKAV		activity, induced; molecular association, regulation; intracellular localization	endocytosis, altered; cell motility, altered; cytoskeletal reorganization; cell adhesion, altered	STAT5A(INDUCES); SH2D1B(NOT_REPORTED); SHP-2(INDUCES); Arg(NOT_REPORTED)		1928; 8502; 3534; 1968321; 27932900; 12482202; 8725; 6185; 3921; 3914	11	13	799	induces switch from heterophilic to homophilic cell-cell aggregation; internalization	
cortactin	Actin binding protein; Cytoskeletal protein; Motility/polarity/chemotaxis	Q14247	2017	CTTN	11q13	human	Y486	PHOSPHORYLATION	447704	YPAEDSTyDEYENDL		molecular association, regulation	cytoskeletal reorganization			3902; 1039	16	1	3	Tyrosine phosphorylation  is necessary for enhanced S1P barrier enhancement.   ; Previous work by the authors showed that src attenuates the actin cross-linking activity of cortactin.  These studies show that transfection with a cortactin mutant (F421/F470/F486) impairs the motility of endothelial cells.	
TFEB	DNA binding protein	Q9R210	21425	Tfeb		mouse	S461	PHOSPHORYLATION	4785127	SPEASKAsSRRSSFS		protein stabilization	transcription, induced			27928005	1	1	0		
MKP-1	EC 3.1.3.16; EC 3.1.3.48; Motility/polarity/chemotaxis; PHOSPHATASE; Protein phosphatase, dual-specificity	P28562	1843	DUSP1	5q34	human	S364	PHOSPHORYLATION	448661	LQSPITTsPSC____		protein stabilization				901	1	0	0		
ARHGEF2 iso2	Guanine nucleotide exchange factor, Rac/Rho; Motility/polarity/chemotaxis	Q92974-2	9181	ARHGEF2	1q21-q22	human	S959	PHOSPHORYLATION	467500	SRLSPPHsPRDFTRM		activity, inhibited	cytoskeletal reorganization			22463911	3	19	12	represses RhoA-dependent stress fiber formation; required for the inactivation of the RhoA-GEF activity of GEF-H1 	
InsR	EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Protein kinase, TK; Protein kinase, tyrosine (receptor)	P06213	3643	INSR	19p13.3-p13.2	human	T1375	PHOSPHORYLATION	450327	KKNGRILtLPRSNPS		enzymatic activity, inhibited; phosphorylation				3667; 3719	6	0	6		
C/EBP-epsilon	DNA binding protein; Motility/polarity/chemotaxis; Transcription factor	Q15744	1053	CEBPE	14q11.2	human	T74	PHOSPHORYLATION	455780	RGLKGPGtPAFPHYL		molecular association, regulation	cell differentiation, altered; transcription, induced	NFkB-p65(INDUCES)	DNA(INDUCES)	5805; 9281	2	0	6		
PKCD	EC 2.7.10.2; EC 2.7.11.13; KINASE; Kinase, protein; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor)	P09215	170538	Prkcd		rat	S643	PHOSPHORYLATION	448591	LNEKPQLsFSDKNLI	Pkinase_C	enzymatic activity, induced				7390	18	26	69		
Ets-1	DNA binding protein; Motility/polarity/chemotaxis; Transcription factor	P13474	396235	ETS1		chicken	S282	PHOSPHORYLATION	449317	QSLQRVPsYDSFDSE		activity, inhibited				3214	3	4	79	The in vitro interaction of  Ets-1 with a high-affinity Ets binding site was assayed with EMSA.	
KCC2	Membrane protein, integral; Membrane protein, multi-pass; Transporter	Q9H2X9	57468	SLC12A5	20q13.12	human	Y1110	PHOSPHORYLATION	3087801	NRNGDENyMEFLEVL		activity, inhibited				8592	3	0	0		
LAT iso2	Adaptor/scaffold; Membrane protein, integral	O43561-2	27040	LAT	16p11.2	human	Y191	PHOSPHORYLATION	448005	SLDGSREyVNVSQEL	LAT	activity, induced; molecular association, regulation; phosphorylation	cell differentiation, altered; cell adhesion, altered; transcription, altered	PLCG1(INDUCES); GADS(INDUCES); Grb2(INDUCES)		3767; 2891; 3632; 1909	22	2	38		
Bub1	Cell cycle regulation; EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor)	O43683	699	BUB1	2q14	human	T609	PHOSPHORYLATION	465611	SAAQLAStPFHKLPV		molecular association, regulation		PLK1(INDUCES)		8096	1	0	0		
H3	DNA binding protein	P68431	8350	HIST1H3A	6p22.1	human	T81	PHOSPHORYLATION	4710889	EIAQDFKtDLRFQSS	Histone		cell growth, induced			27257063	1	6	20	indicator of mitosis and tumor cell proliferation	
PXN	Adaptor/scaffold; Cell adhesion; Cytoskeletal protein; Motility/polarity/chemotaxis	Q8VI36	19303	Pxn		mouse	S250	PHOSPHORYLATION	3653284	SSPQRVTsSQQQTRI	Paxillin	intracellular localization	cell motility, induced			27257018	1	3	17	requred for adhesion turnover	
CTNNB1	Actin binding protein; Cell adhesion; Motility/polarity/chemotaxis; Nuclear receptor co-regulator; Transcription factor	P35222	1499	CTNNB1	3p21	human	Y333	PHOSPHORYLATION	471406	NIMRTYTyEKLLWTT		molecular association, regulation; intracellular localization	cell cycle regulation; carcinogenesis, induced; cell growth, induced; transcription, induced	PKM2(INDUCES)		25185203	2	2	0		
CNR1	GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR	P47746	12801	Cnr1		mouse	T461	PHOSPHORYLATION	22342304	TVKIAKVtMSVSTDT		receptor desensitization, induced				21686207	1	0	1		
FADD	Adaptor/scaffold; Apoptosis	Q13158	8772	FADD	11q13.3	human	S194	PHOSPHORYLATION	447653	QNRSGAMsPMSWNSD		intracellular localization; protein conformation; phosphorylation	cell cycle regulation; apoptosis, altered; carcinogenesis, altered; apoptosis, induced; apoptosis, inhibited			6097; 15754906; 5466; 22463906; 3410; 4835211; 6736	12	16	0	apoptosis and necrosis	
H3 iso3	DNA binding protein	P84244	15081	H3f3b		mouse	S29	PHOSPHORYLATION	455677	ATKAARKsAPSTGGV		activity, induced	transcription, altered; cell growth, altered			6799	38	6	0		
Tel	DNA binding protein; Motility/polarity/chemotaxis; Transcription factor	P41212	2120	ETV6	12p13	human	S213	PHOSPHORYLATION	451376	DNMIRRLsPAERAQG		molecular association, regulation; activity, inhibited	cell differentiation, altered; transcription, inhibited; cell growth, altered		DNA(DISRUPTS)	3580	1	17	2		
POLR2A	EC 2.7.7.48; EC 2.7.7.6; Nucleotide Metabolism - purine; Nucleotide Metabolism - pyrimidine; Transcription initiation complex; Transferase	P24928	5430	POLR2A	17p13.1	human	S1616	PHOSPHORYLATION	450204	TPQSPSYsPTSPSYS	RNA_pol_Rpb1_R	molecular association, regulation; intracellular localization; enzymatic activity, induced	transcription, induced; transcription, altered; transcription, inhibited	INTS11(INDUCES); CTDSP1(INDUCES); CABIN1(INDUCES); HIRA(INDUCES); UBN1(INDUCES)	DNA(INDUCES)	5121516; 14821619; 2672603; 2672602; 2610202; 15031314; 17613008; 25220607; 3433207; 19075402; 6115933	53	0	0	pA site mutation increase  S1616 phosphorylation over the promoter and gene body.	
WHSC1	Amino Acid Metabolism - lysine degradation; EC 2.1.1.43; METHYLTRANSFERASE; Methyltransferase; Methyltransferase, protein lysine; Ubiquitin conjugating system	O96028	7468	WHSC1	4p16.3	human	S102	PHOSPHORYLATION	481737	DAKLRFEsQEMKGIG		molecular association, regulation; methylation; intracellular localization		MDC1(INDUCES)		18410824	1	3	1	;  important for H4K20 methylation; essential for WHSC1 accumulation at DNA damage sites	
CacyBP	Adaptor/scaffold; Ubiquitin conjugating system	Q9HB71	27101	CACYBP	1q24-q25	human	S141	PHOSPHORYLATION	15343403	KPISVEGsSKKVKTD	BamHI; CS	intracellular localization	apoptosis, altered			15235236	1	0	0		
Notch 1	Membrane protein, integral; Motility/polarity/chemotaxis; Receptor, misc.; Transcription factor	Q01705	18128	Notch1		mouse	K1785	ACETYLATION	18899500	GEDSVGLkPLKNASD		protein stabilization; ubiquitination				18899000	1	1	0		
Met	EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Protein kinase, TK; Protein kinase, tyrosine (receptor)	P16056	17295	Met		mouse	S983	PHOSPHORYLATION	450188	PHLDRLVsARSVSPT		enzymatic activity, inhibited				9721216	5	0	0		
LIMK2	EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, Ser/Thr (non-receptor); Protein kinase, TKL	P53671	3985	LIMK2	22q12.2	human	T494	PHOSPHORYLATION	467206	KATTKKRtLRKNDRK	Pkinase_Tyr	intracellular localization				8149	2	0	0	phosphorylation of this site inhibits the nuclear import of LIMK2	
NPY1R	GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR	P21555	29358	Npy1r		rat	S359	PHOSPHORYLATION	2815300	STMHTDVsKTSLKQA		receptor desensitization, altered; receptor internalization, altered				4358	1	0	1	may be an artifact of the truncation mutants	
DDX58	EC 3.6.1.-; EC 3.6.4.13; Hydrolase	O95786	23586	DDX58	9p12	human	S855	PHOSPHORYLATION	17484201	PKPKQFSsFEKRAKI	RIG-I_C-RD	molecular association, regulation; enzymatic activity, inhibited		DDX58(DISRUPTS)		17431516	1	1	0	dephosphorylation of T770, S855, S854 stimulates multimer formation;  	
HHEX	DNA binding protein; Transcription factor	Q03014	3087	HHEX	10q23.33	human	S177	PHOSPHORYLATION	7430501	LAKMLQLsERQVKTW	Homeobox; ArsC; CNP1	molecular association, regulation	transcription, induced		DNA(INDUCES)	7313802	1	0	0		
EPB41 iso2	Cytoskeletal protein	P11171-2	2035	EPB41	1p33-p32	human	S679	PHOSPHORYLATION	467260	DKRLSTHsPFRTLNI	SAB	molecular association, regulation; intracellular localization	cell cycle regulation	NuMA-1(INDUCES); TUBA4A(INDUCES)		8208	1	10	17	Also associates  with tubulin and NuMA in vivo. Mutant EPB41 T60A-S679A abolishes localization to the mitotic spindle. 	
GTF2A1	Transcription, coactivator/corepressor	P52655	2957	GTF2A1	14q31.1	human	S281	PHOSPHORYLATION	449823	DGTGDTSsEEDEDEE	TFIIA; Syndecan		transcription, induced			1829	1	0	0		
TSC2	Cell cycle regulation; GTPase activating protein, misc.; Nuclear receptor co-regulator; Tumor suppressor	P49815	7249	TSC2	16p13.3	human	S1798	PHOSPHORYLATION	454016	GQRKRLIsSVEDFTE		activity, inhibited				4158	2	9	72		
MuSK	EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Protein kinase, TK; Protein kinase, tyrosine (receptor)	Q62838		Musk		rat	Y755	PHOSPHORYLATION	2848300	NIYSADYyKADGNDA	Pkinase_Tyr	phosphorylation; enzymatic activity, induced				2848000	1	1	0	 promotes MuSK phosphorylation; promotes AChRb clustering and phosphorylation	
ATF-2	C2H2-type zinc finger protein; Transcription factor	P15336	1386	ATF2	2q32	human	S62	PHOSPHORYLATION	451440	FGPARNDsVIVADQT		activity, induced; protein stabilization	transcription, induced			3646	2	5	29		
Kir6.2	Channel, potassium; Membrane protein, integral; Membrane protein, multi-pass	Q61743	16514	Kcnj11		mouse	T224	PHOSPHORYLATION	453090	MQVVRKTtSPEGEVV	IRK	activity, induced				3212	3	0	0		
ABCF1	Translation	Q8NE71	23	ABCF1	6p21.33	human	S109	PHOSPHORYLATION	453457	KKLSVPTsDEEDEVP	ABC_tran	molecular association, regulation				762732	1	57	8	S109 aqnd S140 phosphorylation may affect ABCF1-eIF2 binding  to 60S 80S subunits and small polysomes.  	
CHOP	Autophagy; DNA binding protein; Transcription factor	P35638	1649	DDIT3	12q13.1-q13.2	human	S30	PHOSPHORYLATION	455503	EDLQEVLsSDENGGT	CDC45; Peptidase_S64; Macoilin	activity, inhibited	transcription, inhibited			5475	1	0	0		
acinus	Apoptosis; RNA splicing; Spliceosome	Q9UKV3	22985	ACIN1	14q11.2	human	S1180	PHOSPHORYLATION	456759	GPRSRSRsRDRRRKE		intracellular localization	transcription, induced			2831755	3	2	0		
SLC12A3	Membrane protein, integral; Membrane protein, multi-pass; Transporter	P55018	54300	Slc12a3		rat	T48	PHOSPHORYLATION	4709842	SHLTHGStLYLRTFG	AA_permease_N	activity, induced				27132423	2	2	0		
FGFR1	EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Protein kinase, TK; Protein kinase, tyrosine (receptor)	P11362	2260	FGFR1	8p12	human	Y463	PHOSPHORYLATION	448641	MLAGVSEyELPEDPR		molecular association, regulation	cell cycle regulation; transcription, altered; cell growth, altered	Crk(INDUCES)		7324100; 1837	6	2	8		
CCR7	GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Motility/polarity/chemotaxis; Receptor, GPCR	P32248	1236	CCR7	17q12-q21.2	human	T373	PHOSPHORYLATION	455288	MSVEAETtTTFSP__		phosphorylation				4472	1	0	0	ERK1/2 phosphorylation	
MDC1	Cell cycle regulation	Q14676	9656	MDC1	6p21.3	human	T378	PHOSPHORYLATION	477989	ESQAGSDtDVEEGKA		molecular association, regulation	cell cycle regulation	NBS1(INDUCES)		4042508	1	7	27	MDC1-NBS1 interaction regulates intra-S-phase checkpoint activation	
NKCC2	Membrane protein, integral; Membrane protein, multi-pass; Transporter	P55015	100328575	SLC12A1		rabbit	T99	PHOSPHORYLATION	458227	TNTYYLQtFGHNTMD	AA_permease_N	activity, induced				6707	8	2	0		
HIF1A	Autophagy; DNA binding protein; Transcription factor	Q16665	3091	HIF1A	14q23.2	human	S643	PHOSPHORYLATION	470106	KILIASPsPTHIHKE		activity, induced; intracellular localization	transcription, induced; transcription, altered	exportin 1(DISRUPTS)		8935; 6011123	2	0	0		
Jun	Transcription factor	P05627	16476	Jun		mouse	S63	PHOSPHORYLATION	447686	KNSDLLTsPDVGLLK	Jun	activity, induced; sumoylation	apoptosis, induced; cell motility, altered; transcription, induced; transcription, altered; cell growth, altered			2429105; 4504; 2531304; 4914018; 4843007; 4843005	101	19	4		
Kv2.1	Channel, cation; Channel, ligand-gated; Channel, potassium; Membrane protein, integral; Membrane protein, multi-pass	P15387	25736	Kcnb1		rat	S719	PHOSPHORYLATION	473557	LLDKPVLsPESSIYT		activity, inhibited				9216	3	3	0		
separase	EC 3.4.22.49; Protease	Q14674	9700	ESPL1	12q	human	T1363	PHOSPHORYLATION	1211205	AGPHVPFtVFEEVCP		enzymatic activity, inhibited		CDK1(INDUCES)		1172817	1	1	0	phosphorylation of S1399 is a key residue in CDK1-dependent inhibition of separase 	
AIRE	Transcription factor	O43918	326	AIRE	21q22.3	human	T68	PHOSPHORYLATION	1191300	ALLSWLLtQDSTAIL	Sp100		transcription, induced			1172836	1	0	0		
caldesmon	Actin binding protein	P12957	373965	CALD1		chicken	Y27	PHOSPHORYLATION	450224	LEAERLSyQRNDDDE		molecular association, regulation		Shc1(INDUCES)		2912	1	2	13		
SLC24A2	Membrane protein, integral; Membrane protein, multi-pass; Transporter	O54701	84550	Slc24a2		rat	T476	PHOSPHORYLATION	471067	SLSWPSNtRKQITFL		activity, induced				9038	1	0	0	Mutation to alanine of T476 and either T166 or S504 (or possibly both) eliminates PDBu-induced enhancement (PIE) on the Na(+)/Ca(2+)+K(+) exchanger.	
PKR	EC 2.7.10.2; EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor); Translation	P19525	5610	EIF2AK2	2p22-p21	human	T89	PHOSPHORYLATION	3753307	VSPLLLTtTNSSEGL		enzymatic activity, induced				9075	1	0	0		
vimentin	Cytoskeletal protein; Motility/polarity/chemotaxis	P08670	7431	VIM	10p13	human	S5	PHOSPHORYLATION	471086	___MSTRsVSSSSYR			cell motility, altered			7549203	2	5	3		
LEF-1	DNA binding protein; Transcription factor	Q9UJU2	51176	LEF1	4q23-q25	human	S61	PHOSPHORYLATION	471385	KSSLVNEsEIIPASN	CTNNB1_binding	molecular association, regulation	transcription, induced	CTNNB1(INDUCES)		9089	1	0	0		
CTNNB1	Actin binding protein; Cell adhesion; Motility/polarity/chemotaxis; Nuclear receptor co-regulator; Transcription factor	Q02248	12387	Ctnnb1		mouse	S45	PHOSPHORYLATION	447488	GATTTAPsLSGKGNP		protein degradation; ubiquitination				4969204	21	5	0		
PDGFRA	EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Protein kinase, TK; Protein kinase, tyrosine (receptor)	P16234	5156	PDGFRA	4q12	human	Y731	PHOSPHORYLATION	448646	SFENNGDyMDMKQAD	Pkinase_Tyr	molecular association, regulation		PIK3R1(INDUCES)		4332	1	3	34		
NR2C2	DNA binding protein; Nuclear receptor; Transcription factor	P49117	22026	Nr2c2		mouse	S19	PHOSPHORYLATION	467308	STDSAVAsPQRIQIV		activity, inhibited	transcription, altered			8254	1	7	0		
RFA2	DNA replication	P15927	6118	RPA2	1p35	human	S33	PHOSPHORYLATION	448339	GFGSPAPsQAEKKSR		intracellular localization; phosphorylation	cell cycle regulation; apoptosis, altered; cell growth, altered			9980423; 11270029; 9042	14	1	0	critical for repair of DNA breaks induced by replication stress; S33A mutation reduces DNA synthesis; Mutation of these sites to alanine reduces phosphorylation to other RFA2 sites.; 7xAlanine mutant has defect in down regulating DNA synthesis following UV treatment. 7xAspartate mutant did not localize to S-phase foci.	
TAZ	Transcription, coactivator/corepressor	Q9GZV5	25937	WWTR1	3q23-q24	human	S311	PHOSPHORYLATION	1244614	PYHSREQsTDSGLGL		protein degradation; ubiquitination				22631800	1	1	9		
GABRA4	Channel, chloride; Channel, ligand-gated; Membrane protein, integral; Membrane protein, multi-pass	Q9D6F4	14397	Gabra4		mouse	S472	PHOSPHORYLATION	17390700	PASLGSAsTRPAFGS	Neur_chan_memb; KAR9	protein stabilization; intracellular localization				15754900	1	0	0	increases receptor cell surface expression	
HER4	EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Protein kinase, TK; Protein kinase, tyrosine (receptor)	Q15303	2066	ERBB4	2q33.3-q34	human	Y1188	PHOSPHORYLATION	451501	QALDNPEyHNASNGP		molecular association, regulation		Shc1(INDUCES); Arg(INDUCES)		4651319; 3679	0	1	0		
PDK1	EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor)	O55173	81745	Pdpk1		rat	Y376	PHOSPHORYLATION	447694	SEDDEDCyGNYDNLL		enzymatic activity, induced	translation, altered; cell adhesion, altered			4313624	9	1	0	Induces fibronectin expression and deposition and increases AngII mesangial cell hypertrophy	
JAK3	EC 2.7.10.2; KINASE; Kinase, protein; Protein kinase, TK; Protein kinase, tyrosine (non-receptor)	P52333	3718	JAK3	19p13.1	human	Y904	PHOSPHORYLATION	2197001	SLRLVMEyLPSGCLR	Pkinase_Tyr	phosphorylation; enzymatic activity, induced				2195702	1	0	0	required for STAT5A Y694 phosphorylation and its further transcriptional activation	
BubR1	EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor)	O60566	701	BUB1B	15q15	human	T1008	PHOSPHORYLATION	7652107	LNANDEAtVSVLGEL		enzymatic activity, induced	cell cycle regulation			7654400	2	0	0	facilitates chromosome alignment during prometaphase	
SH3GL1	Vesicle protein	Q99961	6455	SH3GL1	19p13.3	human	Y315	PHOSPHORYLATION	450745	QPSCKALyDFEPEND	SH3_1	molecular association, regulation		DYN1(DISRUPTS)		6741	2	2	3		
P130Cas	Adaptor/scaffold; Motility/polarity/chemotaxis	Q61140	12927	Bcar1		mouse	Y253	PHOSPHORYLATION	448721	APGPQDIyDVPPVRG			carcinogenesis, induced; cell motility, induced; cell motility, altered			23013811; 15331022	8	28	706	SH3 and CCH domains are required for P130Cas tyrosine phosphorylation and promoting cell migration.   ; migration, invasion, metastasis	
NR1D1	Nuclear receptor; Transcription factor	P20393	9572	NR1D1	17q11.2	human	S55	PHOSPHORYLATION	471091	CPTYFPPsPTGSLTQ		protein stabilization				12525200	1	1	1		
ALK	EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Protein kinase, TK; Protein kinase, tyrosine (receptor)	Q9UM73	238	ALK	2p23	human	Y1359	PHOSPHORYLATION	1016332	KNCPGPVyRIMTQCW	Pkinase_Tyr	molecular association, regulation	cell growth, altered	Src(INDUCES)		8686	2	1	3		
GDPD5	EC 3.1.-.-; Membrane protein, integral; Membrane protein, multi-pass; Phosphodiesterase	Q640M6	233552	Gdpd5		mouse	T587	PHOSPHORYLATION	27930802	ANANSTAtPVGPRNA		enzymatic activity, induced				27902340	1	1	0		
p53	Activator protein; DNA binding protein; Motility/polarity/chemotaxis; Nuclear receptor co-regulator; Transcription factor; Tumor suppressor	P04637	7157	TP53	17p13.1	human	S20	PHOSPHORYLATION	447529	PLSQETFsDLWKLLP	P53_TAD	activity, induced; protein degradation; protein stabilization; molecular association, regulation; intracellular localization; activity, inhibited; phosphorylation	cell cycle regulation; apoptosis, altered; apoptosis, induced; transcription, altered; cell growth, altered	MDM2(DISRUPTS); Chk2(INDUCES); p300(INDUCES); CBP(INDUCES)		6461; 5197; 2619003; 5010605; 5011204; 2624103; 727; 6466; 6023; 18378508; 5004513; 731; 1173028; 5641; 2433; 5261; 4971006	109	1	0		
Cx43	Channel, misc.; Membrane protein, integral; Membrane protein, multi-pass; Motility/polarity/chemotaxis	P17302	2697	GJA1	6q22.31	human	S262	PHOSPHORYLATION	450694	SPAKDCGsQKYAYFN		molecular association, regulation; intracellular localization	cell growth, altered	KCNJ8(DISRUPTS)		7973; 25723403; 4346	14	6	4	DNA synthesis is decreased in S262A mutant	
Oct7	DNA binding protein; Motility/polarity/chemotaxis; Transcription factor	P31360	18992	Pou3f2		mouse	S362	PHOSPHORYLATION	486486	RKRKKRTsIEVSVKG	Homeobox		cell cycle regulation; cell motility, induced; transcription, induced			22958929	2	0	0	mutation of this site inhibits PAX3 transcription, but not MITF-M transcription	
ARHGEF2	Guanine nucleotide exchange factor, Rac/Rho; Motility/polarity/chemotaxis	Q60875	16800	Arhgef2		mouse	S885	PHOSPHORYLATION	451365	PLDPRRRsLPAGDAL		molecular association, regulation; activity, inhibited	cytoskeletal reorganization	DYNLT1(DISRUPTS); 14-3-3 eta(INDUCES)		12300002	7	19	130	14-3-3 and DYNLT1 biind ARHGEF2 in a mutually exclusive manner.	
SSTR2	GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR	P30680		Sstr2		rat	T354	PHOSPHORYLATION	7652101	KSRLNETtETQRTLL		receptor internalization, altered				18716600	7	0	1		
AML2	DNA binding protein; Transcription factor	Q13761	864	RUNX3	1p36	human	T151	PHOSPHORYLATION	6097702	SGRGKSFtLTITVFT	Runt	protein stabilization; intracellular localization	cell cycle regulation; transcription, altered			6095014	1	1	0		
PLCB3	Carbohydrate Metabolism - inositol phosphate; EC 3.1.4.11; Phospholipase	Q99JE6	29322	Plcb3		rat	S26	PHOSPHORYLATION	448449	VETLRRGsKFIKWDE		enzymatic activity, inhibited				756	1	0	0		
EGFR	EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Protein kinase, TK; Protein kinase, tyrosine (receptor)	Q01279	13649	Egfr		mouse	Y1018	PHOSPHORYLATION	448055	DVVDADEyLIPQQGF			apoptosis, inhibited			6784	38	3	4		
ANPB	EC 4.6.1.2; Guanylyl cyclase; KINASE; Kinase, protein; Lyase; Membrane protein, integral; Nucleotide Metabolism - purine; Protein kinase, RGC; Protein kinase, dual-specificity; Receptor, misc.	P16067	116564	Npr2		rat	S518	PHOSPHORYLATION	450025	AGSRLTLsLRGSSYG	Pkinase_Tyr	activity, induced				2568	2	1	0		
TRPV4	Channel, cation; Membrane protein, integral; Membrane protein, multi-pass	Q9HBA0	59341	TRPV4	12q24.1	human	S824	PHOSPHORYLATION	4777181	LRRDRWSsVVPRVVE		activity, induced				9980421	3	3	0		
POLR2A	EC 2.7.7.48; EC 2.7.7.6; Nucleotide Metabolism - purine; Nucleotide Metabolism - pyrimidine; Transcription initiation complex; Transferase	P24928	5430	POLR2A	17p13.1	human	R1810	DI-METHYLATION	21329100	SYSPSSPrYTPQSPT			transcription, induced	TDRD3(INDUCES)		21328600	1	0	0		
Abi-1	Adaptor/scaffold; Motility/polarity/chemotaxis	Q8CBW3	11308	Abi1		mouse	Y428	PHOSPHORYLATION	3589548	IEKVVAIyDYTKDKD	SH3_1	molecular association, regulation	cell adhesion, altered	Abl(INDUCES)		18415118	1	3	4	;  enhances cell adhesion in Bcr-Abl expressing cells; induces the catalytic activity of c-Abl in vitro	
InsR	EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Protein kinase, TK; Protein kinase, tyrosine (receptor)	P06213	3643	INSR	19p13.3-p13.2	human	S1354	PHOSPHORYLATION	447679	SSLGFKRsYEEHIPY		phosphorylation				3667	2	4	0	No difference between non diabetic normal controls and NIDDM patients InsR phosphorylation at S1354 and T1375	
Casp3	Apoptosis; EC 3.4.22.-; EC 3.4.22.56; Motility/polarity/chemotaxis; Protease	P42574	836	CASP3	4q34	human	S150	PHOSPHORYLATION	450984	FRGDRCRsLTGKPKL	Peptidase_C14	activity, inhibited	apoptosis, inhibited			3248	1	0	0		
STRAP	Adaptor/scaffold; RNA splicing	Q9Y3F4	11171	STRAP	12p12.3	human	S179	PHOSPHORYLATION	11267003	ATMTEVKsLNFNMSV		phosphorylation	apoptosis, altered			11189926	2	0	0	negatively regulates ASK1 phosphorylation and ASK1-mediated signaling 	
Shc1 iso2	Adaptor/scaffold; Apoptosis; Mitochondrial; Motility/polarity/chemotaxis	P29353-2	6464	SHC1	1q21	human	S29	PHOSPHORYLATION	448791	EEWTRHGsFVNKPTR		intracellular localization				9390	2	16	13	after treatment with H2O2, the protein co-localizes with PKCD and co-translocates to the plasma membrane	
AIRE	Transcription factor	O43918	326	AIRE	21q22.3	human	S156	PHOSPHORYLATION	1191301	RGTASPGsQLKAKPP			transcription, induced			1172836	1	0	0		
NPAT	Cell cycle regulation; Transcription regulation	Q14207	4863	NPAT	11q22-q23	human	T1270	PHOSPHORYLATION	2286400	SDLPVPRtPGSGAGE			transcription, induced			2285900	1	0	0	multiple sites deletion mutant	
Syk	EC 2.7.10.2; KINASE; Kinase, protein; Protein kinase, TK; Protein kinase, tyrosine (non-receptor)	P48025	20963	Syk		mouse	Y130	PHOSPHORYLATION	447657	KENLIREyVKQTWNL		molecular association, regulation; protein conformation		Bcr(DISRUPTS)		4042511	3	1	0		
SWAP-70	Guanine nucleotide exchange factor, Rac/Rho	O88443	20947	Swap70		mouse	Y517	PHOSPHORYLATION	450716	RKQALEQyEGVKKKL		molecular association, regulation	cell motility, altered			17675003	1	0	126	;  critical for cell polarization; reduces SWAP-70 binding to F-actin	
NRF2	DNA binding protein; Transcription factor	Q16236	4780	NFE2L2	2q31	human	S215	PHOSPHORYLATION	10292704	VETTMVPsPEAKLTE		intracellular localization	transcription, induced			9983602	1	2	0	moderate effects observed only in NFE2L2-5A mutant	
RFA2	DNA replication	P15927	6118	RPA2	1p35	human	S23	PHOSPHORYLATION	448337	GAGGYTQsPGGFGSP		intracellular localization	cell cycle regulation			22913902; 9980422	6	1	0		
SYN1	Vesicle protein	P09951	24949	Syn1		rat	S551	PHOSPHORYLATION	448377	ARPPASPsPQRQAGP		intracellular localization				11424214	3	14	10		
GCSFR	Membrane protein, integral; Receptor, cytokine	Q99062	1441	CSF3R	1p35-p34.3	human	Y727	PHOSPHORYLATION	451101	LPTLVQTyVLQGDPR		molecular association, regulation		STAT3(INDUCES)		7745	1	0	0		
tau iso8	Cytoskeletal protein	P10636-8	4137	MAPT	17q21.1	human	T181	PHOSPHORYLATION	447932	KTPPAPKtPPSSGEP		intracellular localization	cytoskeletal reorganization			4420; 5955607	40	17	22	The amount of tau in partticulate fraction increased in R406W and V337M mutants compared to WT.	
coronin 1B	Actin binding protein; Motility/polarity/chemotaxis	Q9BR76	57175	CORO1B	11q13.2	human	S2	PHOSPHORYLATION	456131	______MsFRKVVRQ		molecular association, regulation		ARPC2(INDUCES)		6618	4	0	0		
p27Kip1	Cell cycle regulation; Inhibitor protein; Protein kinase, regulatory subunit	P46527	1027	CDKN1B	12p13.1-p12	human	Y89	PHOSPHORYLATION	456819	GSLPEFYyRPPRPPK		molecular association, regulation; intracellular localization; activity, inhibited	cell cycle regulation	CDK2(INDUCES); CDK4(INDUCES)		3394302; 6859	6	0	0	When phosphorylated at Y88 or Y89, p27 able to bind but was unable to inhibit cdk4 in vitro and in vivo.	
Brk	EC 2.7.10.2; KINASE; Kinase, protein; Protein kinase, TK; Protein kinase, tyrosine (non-receptor)	Q64434	20459	Ptk6		mouse	Y447	PHOSPHORYLATION	450276	KLTGITRyENLV___		enzymatic activity, inhibited	RNA stability, altered	Sam68(INDUCES)		9320	5	9	379		
FAM125B	Vesicle protein	Q9H7P6	89853	FAM125B	9q33.3	human	K264	UBIQUITINATION	15167002	VPFMISEkFSCVPES	DUF2464	intracellular localization				15026112	1	0	0		
cPLA2	EC 3.1.1.4; EC 3.1.1.5; Lipid Metabolism - alpha-linolenic acid; Lipid Metabolism - arachidonic acid; Lipid Metabolism - ether lipid; Lipid Metabolism - glycerophospholipid; Lipid Metabolism - linoleic acid; Phospholipase	P47712	5321	PLA2G4A	1q25	human	S727	PHOSPHORYLATION	447599	RQNPSRCsVSLSNVE		molecular association, regulation; intracellular localization; enzymatic activity, induced		S100A10(DISRUPTS); ANXA2(DISRUPTS)	Other(INDUCES)	3404208	8	18	0	activation and localization change (binding membranes) through release of ANXA2	
DACT1	Adaptor/scaffold	Q9NYF0	51339	DACT1	14q23.1	human	S237	PHOSPHORYLATION	18159801	GAVCRSLsTPQFNSL		molecular association, regulation	carcinogenesis, altered; cell growth, altered	14-3-3 beta(INDUCES)		18021025	1	1	0	 ; modulates Wnt signaling	
CFTR	Channel, chloride; EC 3.6.3.49; Hydrolase; Membrane protein, integral; Membrane protein, multi-pass; Transporter	P13569	1080	CFTR	7q31.2	human	S660	PHOSPHORYLATION	449979	FSAERRNsILTETLH	CFTR_R	activity, induced; molecular association, regulation; enzymatic activity, inhibited; protein conformation		CFTR(INDUCES)		4474; 8370; 2537	5	5	0	S660A and S813A mutations alone significantly decreased current compared to wild-type. 	
MEK1	EC 2.7.12.2; KINASE; Kinase, protein; Protein kinase, STE; Protein kinase, dual-specificity	Q02750	5604	MAP2K1	15q22.1-q22.33	human	S212	PHOSPHORYLATION	448283	KLCDFGVsGQLIDSM	Pkinase	enzymatic activity, inhibited				5672	3	1	3		
MITF iso9	DNA binding protein; Transcription factor	O75030-9	4286	MITF	3p14.2-p14.1	human	S409	PHOSPHORYLATION	450265	KTSSRRSsMSMEETE	DUF3371	activity, induced; protein degradation	transcription, induced			27102300; 2968	8	1	0	An MITF double mutant in which S73 and S409 are converted to alanines is both extremely stable and transcriptionally inactive.	
BRF1	Transcription factor	Q07352	677	ZFP36L1	14q22-q24	human	S203	PHOSPHORYLATION	470146	PRLQHSFsFAGFPSA		protein stabilization; molecular association, regulation	transcription, altered; RNA stability, altered	14-3-3 beta(INDUCES)		9014; 2451820	2	0	20	inhibits BRF1-dependent AMD ( ARE-mediated mRNA decay); for its physiological effect phosphorylation of this site cooperates with phosphorylation of S90 and S92	
PDE6G	EC 3.1.4.17; EC 3.1.4.35; Nucleotide Metabolism - purine; Phosphodiesterase	P09174	18588	Pde6g		mouse	T35	PHOSPHORYLATION	450149	PKFKQRQtRQFKSKP	PDE6_gamma	protein conformation; enzymatic activity, induced				9187; 2195470	5	0	0		
DOR-1	GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR	P32300	18386	Oprd1		mouse	T358	PHOSPHORYLATION	449761	ATTRERVtACTPSDG		receptor desensitization, altered; intracellular localization; receptor internalization, altered				18119118; 2306	4	0	0		
CYLD	EC 3.1.2.15; EC 3.4.19.12; Protease; Ubiquitin conjugating system; Ubiquitin-specific protease	Q9NQC7	1540	CYLD	16q12.1	human	S444	PHOSPHORYLATION	12173910	PLSLSAQsVMEELNT		ubiquitination				12156302	1	0	0	induces ubiquitination of TRAF2	
7B2	Chaperone; Secreted; Secreted, signal peptide	P27682	25719	Scg5		rat	S139	PHOSPHORYLATION	457719	APDTAEFsREFQLDQ	Secretogranin_V	molecular association, regulation; activity, inhibited		PCSK2(INDUCES)		7314	1	5	0		
RhoGDI beta	Cell adhesion; G protein regulator, misc.; Motility/polarity/chemotaxis	P52566	397	ARHGDIB	12p12.3	human	Y153	PHOSPHORYLATION	7386101	YGPRPEEyEFLTPVE	Rho_GDI	molecular association, regulation; intracellular localization		RAC1(DISRUPTS)		7313806	2	0	23		
GYS1	Carbohydrate Metabolism - starch and sucrose; EC 2.4.1.11; Transferase	P13834	100008660	GYS1		rabbit	S657	PHOSPHORYLATION	449790	RHSSPHQsEDEEEPR	Glycogen_syn	enzymatic activity, inhibited; phosphorylation				9202; 4917204; 3738	13	12	12		
AhR	DNA binding protein; Nuclear receptor; Transcription factor	P41738	25690	Ahr		rat	Y320	PHOSPHORYLATION	455230	LCNKGSGyQFIHAAD	PAS_3		transcription, altered			4440	2	0	0		
EGFR	EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Protein kinase, TK; Protein kinase, tyrosine (receptor)	P00533	1956	EGFR	7p12	human	T693	PHOSPHORYLATION	448054	RELVEPLtPSGEAPN		molecular association, regulation; receptor internalization, altered		EGF(INDUCES)		1062; 8102; 3851; 3881	12	23	30		
SLC1A1	Membrane protein, integral; Membrane protein, multi-pass; Transporter	P51907	25550	Slc1a1		rat	S465	PHOSPHORYLATION	471076	TGIVEKLsKKELEQV		activity, induced; intracellular localization				9018; 13164213	2	0	0		
ATF-1	Transcription factor	P18846	466	ATF1	12q13	human	S63	PHOSPHORYLATION	449762	GILARRPsYRKILKD	pKID	activity, induced	transcription, induced; transcription, altered; cell growth, altered			721; 4641421; 2415	18	1	29		
p21Cip1	Cell cycle regulation; Inhibitor protein	P38936	1026	CDKN1A	6p21.2	human	K16	UBIQUITINATION	9897001	RQNPCGSkACRRLFG		protein degradation; ubiquitination				5669	2	0	0	UV-induced 	
GUCY2C	EC 4.6.1.2; Guanylyl cyclase; KINASE; Kinase, protein; Lyase; Membrane protein, integral; Nucleotide Metabolism - purine; Protein kinase, RGC; Protein kinase, dual-specificity; Receptor, misc.	P55204	397193	GUCY2C		pig	S1052	PHOSPHORYLATION	451300	RKPTRVAsYKKGTLE		activity, induced				3525	1	1	0	PMA treatment caused additional STa-mediated guanylyl-cyclase activation compared to control. 	
HMGA1	DNA binding protein	P17096	3159	HMGA1	6p21	human	T53	PHOSPHORYLATION	451515	KEPSEVPtPKRPRGR		molecular association, regulation			DNA(INDUCES)	970060	5	23	24	Cdc2 phosphorylated HMGA1 has lower binding affinity than  HIPK2 phosphorylated HMGA1. 	
PARN	EC 3.1.13.4; RNA binding protein; Ribonuclease	O95453	5073	PARN	16p13	human	S557	PHOSPHORYLATION	483559	NHYYRNNsFTAPSTV			cell cycle regulation			19016954	1	16	49		
WNK1	EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor)	Q9H4A3	65125	WNK1	12p13.3	human	T60	PHOSPHORYLATION	450948	EYRRRRHtMDKDSRG		activity, induced				6917	4	2	206	Although phosphorylation of T58 does not alter WNK1 catalytic activity, it is required for activation of SGK1 by IGF-1.	
PDE4A	EC 3.1.4.17; Nucleotide Metabolism - purine; Phosphodiesterase	P54748	25638	Pde4a		rat	S147	PHOSPHORYLATION	3189445	SFLYRSDsDYDMSPK		molecular association, regulation; protein conformation		AIP(DISRUPTS); DISC1(DISRUPTS)		18410830	1	4	2		
ATF-2	C2H2-type zinc finger protein; Transcription factor	P16951	11909	Atf2		mouse	T53	PHOSPHORYLATION	448225	IVADQTPtPTRFLKN			transcription, altered			2324	49	28	36		
NHE1	Membrane protein, integral; Membrane protein, multi-pass; Motility/polarity/chemotaxis; Transporter	P26431	24782	Slc9a1		rat	S776	PHOSPHORYLATION	475074	IRSKEPSsPGTDDVF		activity, induced				9201026	4	2	0		
desmin	Cytoskeletal protein; Motility/polarity/chemotaxis	P17661	1674	DES	2q35	human	T77	PHOSPHORYLATION	449616	RASRLGTtRTPSSYG	Filament_head; IncA; DUF812		cytoskeletal reorganization			2253	1	0	0	Mutated desmin sites showed failure of desmin filaments to segregate into daughter cells. 	
PML iso4	Transcription factor; Tumor suppressor; Ubiquitin conjugating system	P29590-4	5371	PML	15q22	human	S38	PHOSPHORYLATION	451470	EGRQPSPsPSPTERA		protein stabilization	apoptosis, altered			3657	2	5	0	Phosphorylation of PML is associated with enhanced sumoylation and apoptosis induced by As2O3. 	
HMGN1	DNA binding protein	P05114	3150	HMGN1	21q22.2	human	S7	PHOSPHORYLATION	447788	_MPKRKVsSAEGAAK	HMG14_17	intracellular localization				8551	6	14	20	Phosphorylation facilitates localization to non-nuclear pools.	
FOXO3A	Autophagy; DNA binding protein; Transcription factor	O43524	2309	FOXO3	6q21	human	S344	PHOSPHORYLATION	2058401	QDDDAPLsPMLYSSS		protein degradation; molecular association, regulation; activity, inhibited	cell growth, altered	MDM2(INDUCES)		1968337	2	2	0	promotes tumorigenicity	
IRF3	DNA binding protein; Transcription factor	Q14653	3661	IRF3	19q13.3-q13.4	human	S339	PHOSPHORYLATION	2255400	FTEGSGRsPRYALWF	IRF-3	protein degradation; molecular association, regulation	transcription, altered	IRF3(INDUCES); CBP(INDUCES); Pin1(INDUCES)		2865417; 2195490	2	0	0		
CCKBR	GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR	P32239	887	CCKBR	11p15.4	human	T443	PHOSPHORYLATION	17825904	LSYTTIStLGPG___		molecular association, regulation		ARRB1(INDUCES)		17675032	1	0	0		
Per1	Transcription factor	O35973	18626	Per1		mouse	S661	PHOSPHORYLATION	451683	SSSYTASsASDDDKQ		intracellular localization				3802	1	0	0		
CYP19A1	EC 1.14.14.1; Lipid Metabolism - androgen and estrogen; Oxidoreductase	P28649	13075	Cyp19a1		mouse	S118	PHOSPHORYLATION	4661903	HYISRFGsKRGLQCI	p450	enzymatic activity, inhibited				4651310	1	0	0		
ADD2	Cytoskeletal protein; Motility/polarity/chemotaxis	P35612	119	ADD2	2p13.3	human	S713	PHOSPHORYLATION	449802	KKKFRTPsFLKKSKK		protein degradation; intracellular localization	cytoskeletal reorganization			6705; 2346	5	28	154		
GLUT4	Membrane protein, integral; Membrane protein, multi-pass; Transporter	P14672	6517	SLC2A4	17p13	human	S274	PHOSPHORYLATION	478418	LERERPLsLLQLLGS	Sugar_tr	activity, induced				9583	1	0	0	activation of glucose transport	
HuR	RNA binding protein	Q15717	1994	ELAVL1	19p13.2	human	S242	PHOSPHORYLATION	5594500	NVPGNASsGWCIFIY		molecular association, regulation; intracellular localization	cell cycle regulation; cell growth, altered		RNA(DISRUPTS)	5358616	1	0	0	ELAVL1 S242A mutation promotes interaction of the protein with cyclin A2 and cyclin B1 mRNA and cell proliferation 	
Wee1	EC 2.7.10.2; KINASE; Kinase, protein; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor)	P30291	7465	WEE1	11p15.3-p15.1	human	S642	PHOSPHORYLATION	455381	KKMNRSVsLTIY___		intracellular localization; enzymatic activity, inhibited		14-3-3 theta(INDUCES)		6628	4	1	1		
MEF2D	DNA binding protein; Transcription factor	Q14814	4209	MEF2D	1q12-q23	human	S444	PHOSPHORYLATION	449407	SIKSEPVsPSRERSP	Pex14_N	activity, inhibited	transcription, inhibited			7662	3	4	16	S444 phosphorylation required for K439 sumoylation.	
SHP-1	EC 3.1.3.48; Motility/polarity/chemotaxis; PHOSPHATASE; Protein phosphatase, tyrosine (non-receptor)	P29351	15170	Ptpn6		mouse	Y536	PHOSPHORYLATION	448506	QKGQESEyGNITYPP		molecular association, regulation; enzymatic activity, induced		STAT5A(INDUCES)		17613012; 11973	9	16	625		
C/EBP-beta	DNA binding protein; Motility/polarity/chemotaxis; Transcription factor	P17676	1051	CEBPB	20q13.1	human	S288	PHOSPHORYLATION	452156	NNIAVRKsRDKAKMR	I_LWEQ; Nup54; bZIP_2	intracellular localization				3956	3	0	0		
merlin	Cytoskeletal protein; Motility/polarity/chemotaxis	P35240	4771	NF2	22q12.2	human	S10	PHOSPHORYLATION	1720901	GAIASRMsFSSLKRK			cell motility, altered; cytoskeletal reorganization			1713127	2	1	0		
PHB	Apoptosis; Cell cycle regulation; Chaperone; Mitochondrial; Motility/polarity/chemotaxis; Transcription, coactivator/corepressor	P35232	5245	PHB	17q21	human	Y114	PHOSPHORYLATION	6374001	FTSIGEDyDERVLPS	Band_7	O-GlcNAc glycosylation; molecular association, regulation; phosphorylation		SHP-1(INDUCES)		9201012; 6331325	5	0	0	attenuates phosphorylation of Akt T308 and S473	
Rab11A	G protein; G protein, monomeric, Rab; Motility/polarity/chemotaxis	P62491	8766	RAB11A	15q22.31	human	S177	PHOSPHORYLATION	22826101	TEIYRIVsQKQMSDR			endocytosis, inhibited			22736107	1	1	0	S177D mutant led to retained transferrin in the endocytitic recycling compartment.	
CTNNB1	Actin binding protein; Cell adhesion; Motility/polarity/chemotaxis; Nuclear receptor co-regulator; Transcription factor	P35222	1499	CTNNB1	3p21	human	Y654	PHOSPHORYLATION	447585	RNEGVATyAAAVLFR	Arm	activity, induced; protein stabilization; molecular association, regulation	cell growth, induced; transcription, induced; cytoskeletal reorganization; transcription, altered; cell growth, altered	TCF4(INDUCES); TBN(INDUCES); LEF-1(DISRUPTS); Met(DISRUPTS); Smad2(INDUCES); CDH1(DISRUPTS); axin 1(DISRUPTS)		17827004; 20834136; 6842214; 2701903; 4829203; 8232	14	3	21		
JAK2	EC 2.7.10.2; KINASE; Kinase, protein; Protein kinase, TK; Protein kinase, tyrosine (non-receptor)	O60674	3717	JAK2	9p24	human	Y1007	PHOSPHORYLATION	448407	VLPQDKEyYKVKEPG	Pkinase_Tyr	molecular association, regulation		SOCS1(INDUCES)		2531308	46	3	15		
GluR1	Channel, calcium; Channel, ligand-gated; Membrane protein, integral; Membrane protein, multi-pass	P23818	14799	Gria1		mouse	T856	PHOSPHORYLATION	3362101	SINEAIRtSTLPRNS		activity, induced				3361001	1	0	0	synaptic plasticity	
HER4	EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Protein kinase, TK; Protein kinase, tyrosine (receptor)	Q15303	2066	ERBB4	2q33.3-q34	human	Y1162	PHOSPHORYLATION	2045347	RDKPKQEyLNPVEEN		molecular association, regulation		Arg(INDUCES); VAV2(INDUCES)		4651319	0	1	1		
Abi-1	Adaptor/scaffold; Motility/polarity/chemotaxis	Q8IZP0	10006	ABI1	10p11.2	human	S216	PHOSPHORYLATION	3205884	VPNDYMTsPARLGSQ		molecular association, regulation	cell motility, altered; cytoskeletal reorganization			18668222	2	4	28	regulates WRC (WAVE2 regulatory complex) interaction with Arp2/3 and lamellipodial protrusion	
ADCY6	Adenylyl cyclase; EC 4.6.1.1; Lyase; Membrane protein, integral; Membrane protein, multi-pass; Nucleotide Metabolism - purine	AAA40678	25289	Adcy6		rat	S603	PHOSPHORYLATION	467270	WVPDRAFsRTKDSKA	DUF1053	enzymatic activity, induced				8212	1	0	0		
VDAC1	Channel, misc.; Membrane protein, integral; Mitochondrial	P21796	7416	VDAC1	5q31	human	S193	PHOSPHORYLATION	6406004	DGTEFGGsIYQKVNK	Porin_3; TM		apoptosis, inhibited			6369603	2	0	0	S192A mutation results in cell death	
GH receptor	Membrane protein, integral; Receptor, cytokine	NP_999419	397488	GHR		pig	Y534	PHOSPHORYLATION	486256	NFIMDNAyFCEADAK	GHBP		transcription, induced		DNA(INDUCES)	10144217	3	0	0		
DCC	Immunoglobulin superfamily; Membrane protein, integral; Receptor, misc.	P43146	1630	DCC	18q21.3	human	Y1420	PHOSPHORYLATION	454409	TEDSANVyEQDDLSE	Neogenin_C	molecular association, regulation		Lck(INDUCES); Fyn(INDUCES)		1968361	2	0	0		
FANCG	DNA repair	O15287	2189	FANCG	9p13	human	S383	PHOSPHORYLATION	454239	DSSEPRFsPPPSPPG	TPR_16	activity, induced				4241	2	0	0		
helicase B	DNA replication; EC 3.6.1.-; EC 3.6.4.12; Helicase	Q8NG08	92797	HELB	12q14.3|12q	human	S967	PHOSPHORYLATION	451682	APPADFPsPRKSSGD		intracellular localization				3790	1	13	13		
FPR1	GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Motility/polarity/chemotaxis; Receptor, GPCR	P21462	2357	FPR1	19q13.4	human	S338	PHOSPHORYLATION	450845	TSDTATNsTLPSAEV		molecular association, regulation; receptor desensitization, altered; receptor internalization, altered		ARRB2(INDUCES)		7979; 3130	2	0	0		
HAS2	EC 2.4.1.212; Membrane protein, integral; Membrane protein, multi-pass; Motility/polarity/chemotaxis; Transferase	Q92819	3037	HAS2	8q24.12	human	T110	PHOSPHORYLATION	18122801	LQSVKRLtYPGIKVV	Glycos_transf_2	enzymatic activity, inhibited	cell motility, altered; cell adhesion, altered			18021027	1	0	1		
Rb	Nuclear receptor co-regulator; Transcription, coactivator/corepressor; Tumor suppressor	P06400	5925	RB1	13q14.2	human	T373	PHOSPHORYLATION	447982	VNVIPPHtPVRTVMN	RB_A	molecular association, regulation		E2F1(DISRUPTS)		14146309	7	20	35		
GH receptor	Membrane protein, integral; Receptor, cytokine	P16310	25235	Ghr		rat	Y333	PHOSPHORYLATION	455507	ILGIHDNyKPDFYND	GHBP	molecular association, regulation; phosphorylation	transcription, altered	SOCS3(INDUCES)		5357; 8528	3	0	0	JAK2 phosphorylation	
SRC-3	ACETYLTRANSFERASE; Acetyltransferase; EC 2.3.1.48; Motility/polarity/chemotaxis; Nuclear receptor co-regulator; Transcription, coactivator/corepressor	Q9Y6Q9	8202	NCOA3	20q12	human	T1114	PHOSPHORYLATION	4252804	KAGLYGQtYPAQGPP		protein stabilization; molecular association, regulation		PSMA3(DISRUPTS)		4248206	1	0	0	some subset of these 8 residues	
APTX	C2H2-type zinc finger protein; DNA repair; EC 3.-.-.-; Phosphatase (non-protein); RNA binding protein	Q7Z2E3	54840	APTX	9p13.3	human	T125	PHOSPHORYLATION	9397200	AKNPGLEtHRKRKRS		molecular association, regulation; intracellular localization	apoptosis, altered	KPNA1(DISRUPTS)		9201023	1	0	0		
ChAT iso3	ACETYLTRANSFERASE; Acetyltransferase; EC 2.3.1.6; Lipid Metabolism - glycerophospholipid	P28329-3	1103	CHAT	10q11.2	human	T456	PHOSPHORYLATION	449058	VDNIRSAtPEALAFV	Carn_acyltransf	molecular association, regulation		VCP(INDUCES)		2193	1	1	0		
cPLA2	EC 3.1.1.4; EC 3.1.1.5; Lipid Metabolism - alpha-linolenic acid; Lipid Metabolism - arachidonic acid; Lipid Metabolism - ether lipid; Lipid Metabolism - glycerophospholipid; Lipid Metabolism - linoleic acid; Phospholipase	P47713	18783	Pla2g4a		mouse	S726	PHOSPHORYLATION	447599	RQNPSRCsVSLSNVE		enzymatic activity, induced				1041	8	18	0		
GYS1	Carbohydrate Metabolism - starch and sucrose; EC 2.4.1.11; Transferase	P13834	100008660	GYS1		rabbit	S641	PHOSPHORYLATION	448237	YRYPRPAsVPPSPSL	Glycogen_syn	enzymatic activity, inhibited				9217; 7139; 3399; 2739; 1381; 4917204; 3738	26	12	2		
Shc1	Adaptor/scaffold; Apoptosis; Mitochondrial; Motility/polarity/chemotaxis	P29353	6464	SHC1	1q21	human	S36	PHOSPHORYLATION	448508	TPPEELPsPSASSLG		molecular association, regulation; phosphorylation	apoptosis, induced	MIA(DISRUPTS)		7230; 7177; 8093; 11474	14	0	0		
LAT	Adaptor/scaffold; Membrane protein, integral	O43561	27040	LAT	16p11.2	human	Y255	PHOSPHORYLATION	448006	EEEGAPDyENLQELN		activity, induced; molecular association, regulation	transcription, altered	PLCG1(INDUCES); Grb2(INDUCES)		8611	9	2	76	NF-AT mediated transcription	
VIPR1	GPCR, family 2; Membrane protein, integral; Membrane protein, multi-pass; Motility/polarity/chemotaxis; Receptor, GPCR	P32241	7433	VIPR1	3p22	human	S250	PHOSPHORYLATION	455875	LLAVSFFsERKYFWG	7tm_2	receptor internalization, altered				6339	2	0	0		
ETV1	DNA binding protein; Transcription factor	P50549	2115	ETV1	7p21.3	human	S334	PHOSPHORYLATION	3059601	PTYQRRGsLQLWQFL	Ets	molecular association, regulation	transcription, induced		DNA(DISRUPTS)	8495	1	0	0		
HP1 alpha	Transcription, coactivator/corepressor	Q61686	12419	Cbx5		mouse	S13	PHOSPHORYLATION	476164	KRTADSSsSEDEEEY		molecular association, regulation		H3(INDUCES)	DNA(INDUCES)	18021019	1	22	2	important for chromosomal stability	
vinculin	Cell adhesion; Cytoskeletal protein; Motility/polarity/chemotaxis	P12003	396422	VCL		chicken	Y1134	PHOSPHORYLATION	454003	WVRKTPWyQ______	Vinculin	activity, induced; intracellular localization; protein conformation	cell adhesion, altered			17431538; 9158100; 4154	6	1	20	phosphorylation of this site positively regulates cell spreading; plays an important role in vinculin exchange dynamics	
restin	Cytoskeletal protein	Q9JK25	65201	Rsn		rat	T286	PHOSPHORYLATION	483203	KIGFPSTtPAKAKAA		intracellular localization	cell cycle regulation			9980411	2	1	2	essential for G2/M transition and cell cycle progression	
CDK4	EC 2.7.11.22; KINASE; Kinase, protein; Protein kinase, CMGC; Protein kinase, Ser/Thr (non-receptor)	P11802	1019	CDK4	12q14	human	T172	PHOSPHORYLATION	448476	YSYQMALtPVVVTLW	Pkinase	enzymatic activity, induced				7613715; 2452300	6	2	2		
LIME1	Adaptor/scaffold; Membrane protein, integral	Q9H400	54923	LIME1	20q13.3	human	Y254	PHOSPHORYLATION	463811	SGPLENVyESIRELG		molecular association, regulation		Lck(INDUCES); Fyn(INDUCES)		12482278	3	1	14		
CRMP-4	Hydrolase	Q14195	1809	DPYSL3	5q32	human	S522	PHOSPHORYLATION	458800	PAGSARGsPTRPNPP			cell motility, altered			1300300	3	22	6	increases axon length	
IP3R2	Channel, calcium; Channel, ligand-gated; Membrane protein, integral; Membrane protein, multi-pass; Receptor, misc.	Q9Z329	16439	Itpr2		mouse	S937	PHOSPHORYLATION	468039	QMVLSRGsIFPVSVP		activity, induced				9689410	1	5	0		
GTF2B	ACETYLTRANSFERASE; Acetyltransferase; Transcription factor	Q00403	2959	GTF2B	1p22-p21	human	S65	PHOSPHORYLATION	13823200	DKATKDPsRVGDSQN		molecular association, regulation	transcription, induced	CSTF2(INDUCES)		13354735	1	0	1		
MEF2C	DNA binding protein; Transcription factor	Q8CFN5	17260	Mef2c		mouse	S240	PHOSPHORYLATION	456976	NKNIQAKsPPPMNLG		molecular association, regulation		Pin1(INDUCES)		15235218	1	11	0	Pin1 binding decreases MEF2C stability and its transcriptional activity	
nAChRA7	Channel, cation; Channel, ligand-gated; Membrane protein, integral; Membrane protein, multi-pass	P36544	1139	CHRNA7	15q14	human	Y386	PHOSPHORYLATION	457466	ASNGNLLyIGFRGLD	Neur_chan_memb	activity, inhibited				6962	1	0	0		
TTK	Cancer Testis Antigen (CTA); EC 2.7.12.1; KINASE; Kinase, protein; Protein kinase, Other; Protein kinase, dual-specificity	P33981	7272	TTK	6q13-q21	human	T806	PHOSPHORYLATION	4145514	NQMAKGTtEEMKYVL		enzymatic activity, inhibited				4042509	1	0	0	in vitro	
CCR5	GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Motility/polarity/chemotaxis; Receptor, GPCR; Receptor, cytokine	P51681	1234	CCR5	3p21.31	human	S336	PHOSPHORYLATION	449901	QEAPERAsSVYTRST		molecular association, regulation; receptor desensitization, altered; receptor internalization, altered; activity, inhibited		ARRB1(INDUCES); ARRB2(INDUCES)		2453; 3438; 5346	4	0	0		
CD5	Cell surface; Membrane protein, integral	P06127	921	CD5	11q13	human	T434	PHOSPHORYLATION	450129	MSFHRNHtATVRSHA		activity, induced; receptor internalization, altered				2735	1	0	44		
Myc	DNA binding protein; Transcription factor	P01108	17869	Myc		mouse	T358	PHOSPHORYLATION	450960	EENDKRRtHNVLERQ	HLH	activity, inhibited	cell cycle regulation; apoptosis, inhibited; transcription, altered; transcription, inhibited; cell growth, altered			12524163; 3233	3	0	0	mutation of this site enhances epidermal differentiation	
NOXA1	Activator protein	Q8CJ00	241275	Noxa1		mouse	Y252	PHOSPHORYLATION	12570900	GHTSPGLyDSLLASR		activity, inhibited				13359106	2	0	0	inhibits Nox1 activity	
MED1	Nuclear receptor co-regulator; Transcription, coactivator/corepressor	Q15648	5469	MED1	17q12	human	T1032	PHOSPHORYLATION	458308	SSSNRPFtPPTSTGG		activity, induced; protein stabilization; intracellular localization				7393	3	0	1		
TrkA	EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Protein kinase, TK; Protein kinase, tyrosine (receptor)	P04629	4914	NTRK1	1q21-q22	human	Y681	PHOSPHORYLATION	447764	DIYSTDYyRVGGRTM	Pkinase_Tyr	receptor internalization, altered; enzymatic activity, induced				5955616	9	1	8		
ChAT iso3	ACETYLTRANSFERASE; Acetyltransferase; EC 2.3.1.6; Lipid Metabolism - glycerophospholipid	P28329-3	1103	CHAT	10q11.2	human	S476	PHOSPHORYLATION	454037	HKAAVPAsEKLLLLK	Carn_acyltransf	enzymatic activity, induced				4182	1	0	0		
NACA	Motility/polarity/chemotaxis; Transcription, coactivator/corepressor	E9PAV3	4666	NACA	12q23-q24.1	human	S1906	PHOSPHORYLATION	454238	PELEEQDsTQATTQQ		activity, induced; intracellular localization	transcription, induced			4238	2	0	0		
Chk2	EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, CAMK; Protein kinase, Ser/Thr (non-receptor)	O96017	11200	CHEK2	22q12.1	human	S164	PHOSPHORYLATION	12473002	IAYIEDHsGNGTFVN	FHA	enzymatic activity, inhibited	cell cycle regulation			12190200	1	1	0	mutation of this site impairs checkpoint recovery	
Shc1	Adaptor/scaffold; Apoptosis; Mitochondrial; Motility/polarity/chemotaxis	P98083	20416	Shc1		mouse	S139	PHOSPHORYLATION	448791	EEWTRHGsFVNKPTR		molecular association, regulation		PTP-PEST(INDUCES)		1955	2	16	13	binding to PTPN12 down-regulates insulin-induced ERK activation	
GATA4	Motility/polarity/chemotaxis; Transcription factor	P46152	54254	Gata4		rat	S105	PHOSPHORYLATION	449604	AYTPPPVsPRFSFPG	GATA-N	activity, induced; phosphorylation	cell growth, induced; apoptosis, inhibited; transcription, induced; transcription, altered		DNA(INDUCES)	9260; 2246; 22736113; 25334200; 8523; 11424209	12	0	0	increase in cell size ; mediates synergy with SRF in promoter activation 	
KCNMA1	Channel, potassium; Endoplasmic reticulum; Membrane protein, integral; Membrane protein, multi-pass	Q8AYS8	374065	KCNMA1		chicken	T871	PHOSPHORYLATION	4715376	QANSQGFtPPGMDRS		intracellular localization; activity, inhibited				22463944	1	3	0		
GIRK1	Channel, potassium; Membrane protein, integral; Membrane protein, multi-pass	NP_113798	50599	Kcnj3		rat	S185	PHOSPHORYLATION	450683	GCMFIKMsQPKKRAE	IRK	activity, inhibited				3086	1	0	0	inhibition of channel open-state probability	
PKACA	EC 2.7.11.11; KINASE; Kinase, protein; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor)	P17612	5566	PRKACA	19p13.1	human	S339	PHOSPHORYLATION	449886	EEEEIRVsINEKCGK	Pkinase_C	protein stabilization				8738	8	20	19		
dematin iso2	Actin binding protein; Motility/polarity/chemotaxis	Q08495-2	2039	EPB49	8p21.1	human	S381	PHOSPHORYLATION	450255	NELKKKAsLF_____	VHP	protein conformation	cytoskeletal reorganization			27519656	4	0	0	Phosphorylation of S381 eliminates the F-actin bundling activity, induced a compact quartenary structure, and caused the headpiece to associate with the core domain. 	
AQP2	Channel, misc.; Membrane protein, integral; Membrane protein, multi-pass	P56402	11827	Aqp2		mouse	S261	PHOSPHORYLATION	464644	RQSVELHsPQSLPRG		intracellular localization				12728102	15	7	0	plasma membrane abundance	
AQP2	Channel, misc.; Membrane protein, integral; Membrane protein, multi-pass	P56402	11827	Aqp2		mouse	S269	PHOSPHORYLATION	3339002	PQSLPRGsKA_____		protein stabilization; molecular association, regulation; intracellular localization	endocytosis, altered	HSP70(DISRUPTS)		12728102; 3301212	12	3	0		
FGFR2	EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Protein kinase, TK; Protein kinase, tyrosine (receptor)	P21802	2263	FGFR2	10q26	human	S782	PHOSPHORYLATION	2532302	PLEQYSPsYPDTRSS		molecular association, regulation	cell cycle regulation; cell growth, altered	14-3-3 zeta(INDUCES)		2425204	2	0	0	reguates cell survival in response to FGF2	
ERK2	EC 2.7.11.24; KINASE; Kinase, protein; Protein kinase, CMGC; Protein kinase, Ser/Thr (non-receptor)	P28482	5594	MAPK1	22q11.21	human	T190	PHOSPHORYLATION	3949250	FLTEYVAtRWYRAPE	Pkinase; YukC	molecular association, regulation; protein conformation; enzymatic activity, induced		GNB1(INDUCES)		6842222	1	8	21		
CSFR	EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Protein kinase, TK; Protein kinase, tyrosine (receptor)	P09581	12978	Csf1r		mouse	Y807	PHOSPHORYLATION	448365	DIMNDSNyVVKGNAR	Pkinase_Tyr	molecular association, regulation; enzymatic activity, induced	cell cycle regulation; apoptosis, altered; cell differentiation, altered; apoptosis, inhibited; transcription, induced; transcription, altered; cell growth, altered	PLCG1(INDUCES)		5366; 7324131; 2852634; 4651302; 3760; 2852611; 1173037; 2718	21	2	12		
MuSK	EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Protein kinase, TK; Protein kinase, tyrosine (receptor)	Q62838		Musk		rat	Y553	PHOSPHORYLATION	2848304	RLHPNPMyQRMPLLL		phosphorylation; enzymatic activity, induced				2848000	1	2	0	 promotes MuSK phosphorylation; promotes AChRb clustering and phosphorylation	
IL9R	Membrane protein, integral; Receptor, cytokine	Q01113	3581	IL9R	Xq28 and Yq12	human	Y407	PHOSPHORYLATION	10306403	WRVQTLAyLPQEDWA			apoptosis, inhibited; cell growth, altered		DNA(INDUCES)	10144216	1	0	0	required for IL9-induced binding to GRR oligonucleotide complex containing activated STAT1-alpha, STAT3 and STAT5.	
BARD1	EC 6.3.2.-; EC 6.3.2.19; Ligase; Tumor suppressor; UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase	Q99728	580	BARD1	2q34-q35	human	S391	PHOSPHORYLATION	455774	SDEFISLsPGTPPST			cell cycle regulation			5849	1	5	0	resistance to genotoxic stress (mitomycin C)	
PPP1R14A	Inhibitor protein; Protein phosphatase, regulatory subunit	Q99MC0	114004	Ppp1r14a		rat	T38	PHOSPHORYLATION	449098	QKRHARVtVKYDRRE	PP1_inhibitor	activity, inhibited; phosphorylation				8629	26	0	0	upregulates the inhibition on PP1delta activity	
CAD	Amino Acid Metabolism - alanine, aspartate and glutamate; EC 2.1.3.2; EC 3.5.2.3; EC 6.3.5.5; Hydrolase; KINASE; Ligase; Nucleotide Metabolism - pyrimidine; Transferase	P27708	790	CAD	2p22-p21	human	T456	PHOSPHORYLATION	451248	KVYFLPItPHYVTQV	CPSase_L_chain	intracellular localization				6634	6	0	0		
ataxin-3	DNA repair; EC 3.4.19.12; EC 3.4.22.-; Protease; Transcription regulation; Ubiquitin-specific protease	P54252	4287	ATXN3	14q21	human	S256	PHOSPHORYLATION	479405	LRRAIQLsMQGSSRN	Dicty_REP; UIM	molecular association, regulation				11456	2	0	0	 ; phosphorylation of this site prevents protein aggregation;  excessive aggregation of mutant S256A is inhibited by Hsp70	
IRSp53	Actin binding protein; Motility/polarity/chemotaxis	Q9UQB8	10458	BAIAP2	17q25	human	S366	PHOSPHORYLATION	468035	KTLPRSSsMAAGLER		molecular association, regulation	cytoskeletal reorganization	14-3-3 theta(INDUCES)		18119113	2	21	22	regulates cell spreading	
CDK5R2	Protein kinase, regulatory subunit	Q13319	8941	CDK5R2	2q35	human	S8	PHOSPHORYLATION	15499459	MGTVLSLsPASSAKG	CDK5_activator	intracellular localization				25083305	1	0	1	CDK5R2 S8 in its unphosphorylated form accumulates at the perinuclear region and T84 plays a role in the nuclear localization of CDK5R2.	
GEM	G protein; G protein, monomeric, RGK	P55041	14579	Gem		mouse	S286	PHOSPHORYLATION	1211200	NMAFKLKsKSCHDLS		molecular association, regulation; intracellular localization		14-3-3 beta(DISRUPTS)		1172800	2	1	0		
PLB	Inhibitor protein; Membrane protein, integral	NP_073198	64672	Pln		rat	T17	PHOSPHORYLATION	448115	SAIRRAStIEMPQQA	Phospholamban; BatA	activity, induced				1709	42	6	53		
PLD2	EC 3.1.4.4; Lipid Metabolism - ether lipid; Lipid Metabolism - glycerophospholipid; Motility/polarity/chemotaxis; Phospholipase	O14939	5338	PLD2	17p13.1	human	T566	PHOSPHORYLATION	15343400	FIQRWNFtKTTKAKY		intracellular localization	cytoskeletal reorganization			15235223	1	0	0	required for integrin-mediated cell spreading	
ARHGEF7 iso1	Guanine nucleotide exchange factor, Rac/Rho; Motility/polarity/chemotaxis	Q14155-1	8874	ARHGEF7	13q34	human	Y442	PHOSPHORYLATION	3753309	PAPLTPAyHTLPHPS		molecular association, regulation	cell motility, altered	GIT1(DISRUPTS)		14058608	2	0	3	stimulates interaction of GIT1 with paxillin	
HuR	RNA binding protein	Q15717	1994	ELAVL1	19p13.2	human	S100	PHOSPHORYLATION	474553	VSYARPSsEVIKDAN			RNA stability, altered		RNA(INDUCES)	9316	2	0	1	Phosphorylation by Chk2 regulates binding of ELAV1 to mRNAs affecting mRNA stabliity.	
HSF1	DNA binding protein; Transcription factor	Q00613	3297	HSF1	8q24.3	human	S326	PHOSPHORYLATION	455484	SSVDTLLsPTALIDS	Vert_HS_TF	activity, induced	transcription, altered			5213	4	10	12		
CSFR	EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Protein kinase, TK; Protein kinase, tyrosine (receptor)	P07333	1436	CSF1R	5q32	human	Y708	PHOSPHORYLATION	451528	NIHLEKKyVRRDSGF	Pkinase_Tyr	activity, induced; molecular association, regulation		STAT1(INDUCES)		7325702	12	0	0		
AMPKA2	Autophagy; EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, CAMK; Protein kinase, Ser/Thr (non-receptor)	Q09137	78975	Prkaa2		rat	T172	PHOSPHORYLATION	448026	SDGEFLRtSCGSPNY	Pkinase; YukC	enzymatic activity, induced				905; 1173015; 451	47	9	19		
caveolin-2	Adaptor/scaffold; Motility/polarity/chemotaxis	P51636	858	CAV2	7q31.1	human	S23	PHOSPHORYLATION	460671	DDSYSHHsGLEYADP	Caveolin	activity, induced				8324	4	14	77	formation of caveolae	
lamin A/C	Cytoskeletal protein	P02545	4000	LMNA	1q22	human	S657	PHOSPHORYLATION	4661905	NSSPRTQsPQNCSIM		activity, induced; intracellular localization				4641430	1	0	0	nuclear lamin disassemby	
STLK3	EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, STE; Protein kinase, Ser/Thr (non-receptor)	Q9UEW8	27347	STK39	2q24.3	human	S371	PHOSPHORYLATION	456506	VRRVPGSsGHLHKTE		enzymatic activity, induced				2195492	10	9	1		
PDGFRB	EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Protein kinase, TK; Protein kinase, tyrosine (receptor)	P09619	5159	PDGFRB	5q33.1	human	Y934	PHOSPHORYLATION	447518	AHASDEIyEIMQKCW	Pkinase_Tyr	enzymatic activity, induced	cell motility, altered			7324304	1	2	1	in vitro	
PTPRA iso2	EC 3.1.3.48; Membrane protein, integral; Motility/polarity/chemotaxis; PHOSPHATASE; Receptor protein phosphatase, tyrosine	P18433-2	5786	PTPRA	20p13	human	Y789	PHOSPHORYLATION	447613	YIDAFSDyANFK___		molecular association, regulation; enzymatic activity, induced		Src(INDUCES); Grb2(INDUCES)		2566; 3636; 1711	13	48	2297		
STAT2	DNA binding protein; Transcription factor	P52630	6773	STAT2	12q13.3	human	S287	PHOSPHORYLATION	27259020	KGLSCLVsYQDDPLT	STAT_alpha	intracellular localization	cell growth, inhibited; transcription, inhibited		DNA(DISRUPTS)	27257022	1	1	0	phosphorylation limits nuclear translocalization 	
SIPA1L1	GTPase activating protein, Ras	Q8C0T5	217692	Sipa1l1		mouse	S1328	PHOSPHORYLATION	3595500	SLGASTSsPRSGPGK		protein degradation; molecular association, regulation		PLK2(INDUCES)		2915506	1	1	0		
GABRB3	Channel, chloride; Channel, ligand-gated; Membrane protein, integral; Membrane protein, multi-pass	P15433	14402	Gabrb3		mouse	S406	PHOSPHORYLATION	486453	GIQYRKQsMPKEGHG	Neur_chan_memb	activity, induced				11468	3	0	0	potentiated GABA currents	
THEMIS2	Adaptor/scaffold; Cell adhesion; Motility/polarity/chemotaxis	Q91YX0	230787	Themis2		mouse	Y660	PHOSPHORYLATION	9415036	PDMDDHDyEEI____		molecular association, regulation		Lyn(INDUCES); Grb2(INDUCES)		15022723	1	2	20	promotes LPS-induced TNF production	
NFAT5	Transcription factor	O94916	10725	NFAT5	16q22.1	human	Y143	PHOSPHORYLATION	12127405	PKRHTVLyISPPPED		activity, induced; molecular association, regulation; intracellular localization	transcription, induced; transcription, altered	PLCG1(INDUCES)		14784601; 12021308; 13354732	4	1	0		
NUMB	Cell development/differentiation; Tumor suppressor	P49757	8650	NUMB	14q24.3	human	T102	PHOSPHORYLATION	3333403	LRVVDEKtKDLIVDQ	PID	activity, induced; intracellular localization	endocytosis, altered			3309510	1	0	0		
CUTL1	DNA binding protein; Membrane protein, integral; Transcription factor	P39880	1523	CUX1	7q22.1	human	S1237	PHOSPHORYLATION	456479	TEYSQGAsPQPQHQL			transcription, inhibited			7781	2	1	4		
CRF-R1 iso2	GPCR, family 2; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR	P34998-2	1394	CRHR1	17q12-q22	human	T399	PHOSPHORYLATION	454252	ARAMSIPtSPTRVSF		receptor desensitization, altered				4248	1	0	0		
CACNA1B	Channel, calcium; Membrane protein, integral; Membrane protein, multi-pass	Q02294	257648	Cacna1b		rat	T422	PHOSPHORYLATION	465546	AVLKRAAtKKSRNDL		activity, induced				6337819; 9384; 7994	4	0	0		
VEGFR1	EC 2.7.1.112; EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Protein kinase, TK; Protein kinase, tyrosine (receptor)	P17948	2321	FLT1	13q12	human	Y1333	PHOSPHORYLATION	448212	DYNSVVLySTPPI__		protein degradation; molecular association, regulation; receptor internalization, altered	cell cycle regulation; cell growth, altered	Cbl(INDUCES); Crk(INDUCES); PLCG1(INDUCES); Nck1(INDUCES)		1403; 8509; 1404	3	0	0	mutation to phenylalanine caused increased tyrosine phosphorylation of PLCG1	
TREK-2	Channel, potassium; Membrane protein, integral; Membrane protein, multi-pass	Q9JIS4	65272	Kcnk10		rat	S326	PHOSPHORYLATION	465529	GDWLRVLsKKTKEEV		activity, inhibited				7974; 11820	2	0	0	relative channel activity reduced in S326D and S359D mutants;  shift of gating modes; inhibition mediated by ACh	
NOXA1	Activator protein	Q86UR1	10811	NOXA1	9q34.3	human	S282	PHOSPHORYLATION	12570900	VGKQAPLsPGLPAMG		molecular association, regulation		RAC1(DISRUPTS); NOX1(DISRUPTS)		12558706	2	0	0	prevents hyperactivation of NOX1	
Kv2.1	Channel, cation; Channel, ligand-gated; Channel, potassium; Membrane protein, integral; Membrane protein, multi-pass	P15387	25736	Kcnb1		rat	Y128	PHOSPHORYLATION	449085	YWGIDEIyLESCCQA	K_tetra	activity, induced; molecular association, regulation; intracellular localization		PTPRE(INDUCES)		22736104; 2116	5	0	0	regulates intracellular trafficking of Kv2.1; Interaction with PTP-epsilon results in dephosphorylation of Kv2.1.	
RENT1	C2H2-type zinc finger protein; EC 3.6.1.-; EC 3.6.4.-; Hydrolase	Q92900	5976	UPF1	19p13.2-p13.11	human	S1107	PHOSPHORYLATION	456314	SQIDVALsQDSTYQG		molecular association, regulation		SMG5(INDUCES)		28722188	6	21	26	regulates nonsense-mediated RNA decay, phosphorylation blocked by MARVELD1	
GOLGA3	Vesicle protein	P55937	269682	Golga3		mouse	S385	PHOSPHORYLATION	478659	EVRSRRDsICSSVSM			apoptosis, altered			12260	1	2	28	protected against Brefeldin-A-induced apoptosis, but not Fas-mediated apoptosis.	
EDG-1	GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR	P21453	1901	S1PR1	1p21	human	T236	PHOSPHORYLATION	447691	RTRSRRLtFRKNISK	7tm_1		cell motility, altered; cytoskeletal reorganization			1313	1	1	0	Cortical actin assembly, chemotaxis, and angiogenesis	
GluR2	Channel, calcium; Channel, ligand-gated; Membrane protein, integral; Membrane protein, multi-pass	P19491	29627	Gria2		rat	Y876	PHOSPHORYLATION	452173	YKEGYNVyGIESVKI		molecular association, regulation; receptor internalization, altered		IQSEC1(INDUCES)		4090; 15031326	2	3	110	regulates Arf6 exchange factor activity	
Bcr	EC 2.7.11.1; GTPase activating protein, Rac/Rho; KINASE; Kinase, protein; Protein kinase, ATYPICAL; Protein kinase, Ser/Thr (non-receptor)	Q6PAJ1	110279	Bcr		mouse	Y362	PHOSPHORYLATION	447796	VSPSPTTyRMFRDKS		enzymatic activity, inhibited	cell growth, altered			970041	4	1	29		
IKKB	EC 2.7.11.10; KINASE; Kinase, protein; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor)	O14920	3551	IKBKB	8p11.2	human	S177	PHOSPHORYLATION	447492	AKELDQGsLCTSFVG	Pkinase	activity, induced; intracellular localization; enzymatic activity, induced	transcription, altered	IKKA(INDUCES)		1736; 8475002; 6379; 813	25	0	0		
osteopontin	Secreted; Secreted, signal peptide	P10451	6696	SPP1	4q22.1	human	S120	PHOSPHORYLATION	455737	DTDDSHQsDESHHSD	Osteopontin	molecular association, regulation; activity, inhibited			Other(INDUCES)	10425106	1	3	0	peptide with phosphorylated S117, S120, S123, S126 and S129 has increased binding to hydroxyapatite, and inhibits bone mineralization in vivo and in vitro 	
ataxin-10		Q9UBB4	25814	ATXN10	22q13.31	human	S77	PHOSPHORYLATION	21514207	QVENLASsLQLITEC	WAPL	protein degradation; ubiquitination	cell cycle regulation			21390205	1	1	0	required for cytokinesis	
RanGAP1	GTPase activating protein, Ras; GTPase activating protein, misc.	P46060	5905	RANGAP1	22q13	human	S358	PHOSPHORYLATION	458865	AKVLASLsDDEDEEE	Nop14; SDA1; Spore_coat_CotO; Plasmodium_Vir; CDC45; Sigma70_ner; Ycf1; CPSF100_C; Drc1-Sld2; Tim54; RRN3; Paf1; Daxx; YqfQ	molecular association, regulation		RAN(INDUCES); RanBP1(INDUCES)		7485	1	3	0		
BRAF	EC 2.7.1.37; EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, Ser/Thr (non-receptor); Protein kinase, TKL	Q04982	396239	BRAF		chicken	S486	PHOSPHORYLATION	447804	KTLGRRDsSDDWEIP		enzymatic activity, induced				7878	8	26	53	important for cell differentiation	
FOXA2	DNA binding protein; Transcription factor	Q9Y261	3170	FOXA2	20p11	human	T156	PHOSPHORYLATION	4911901	KTYRRSYtHAKPPYS	Fork_head_N	intracellular localization	transcription, altered			4910501	2	0	0		
VDAC1	Channel, misc.; Membrane protein, integral; Mitochondrial	P21796	7416	VDAC1	5q31	human	S13	PHOSPHORYLATION	479874	TYADLGKsARDVFTK	Porin_3	protein stabilization	apoptosis, induced			2704314	1	2	0		
GTF2B	ACETYLTRANSFERASE; Acetyltransferase; Transcription factor	Q00403	2959	GTF2B	1p22-p21	human	K238	ACETYLATION	458997	AATHIARkAVELDLV	TFIIB	molecular association, regulation	transcription, altered	GTF2F2(INDUCES)		7555	1	1	0		
PRC1	Cell cycle regulation; Cytoskeletal protein; Microtubule binding protein; Motility/polarity/chemotaxis	O43663	9055	PRC1	15q26.1	human	S577	PHOSPHORYLATION	26331401	FSINSVAsTYSEFAK	MAP65_ASE1	phosphorylation				25785411	1	0	0	Docking site phosphorylation at T616 is regulated  T578  phosphorylation.	
FAK	EC 2.7.1.112; EC 2.7.10.2; KINASE; Kinase, protein; Protein kinase, TK; Protein kinase, tyrosine (non-receptor)	Q05397	5747	PTK2	8q24.3	human	Y576	PHOSPHORYLATION	447889	RYMEDSTyYKASKGK	Pkinase_Tyr	activity, induced; intracellular localization; phosphorylation; enzymatic activity, induced	cell differentiation, altered; cell motility, induced; cell adhesion, altered; cytoskeletal reorganization; transcription, altered			5627; 27856300; 4894707; 2621609; 4445; 2865401; 7167	68	40	2552		
Ron	EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Protein kinase, TK; Protein kinase, tyrosine (receptor)	Q04912	4486	MST1R	3p21.3	human	Y1317	PHOSPHORYLATION	456484	EYCPDSLyQVMQQCW	Pkinase_Tyr		cell growth, altered			4335	2	0	0		
MRLC2	Contractile protein	O14950	103910	MYL12B	18p11.31	human	T19	PHOSPHORYLATION	448596	KKRPQRAtSNVFAMF	2-Hacid_dh_C		cell motility, altered; cytoskeletal reorganization			5280; 6842209; 6275	31	23	266		
JAK1	EC 2.7.10.2; KINASE; Kinase, protein; Protein kinase, TK; Protein kinase, tyrosine (non-receptor)	P52332	16451	Jak1		mouse	Y939	PHOSPHORYLATION	3345201	YHENIVKyKGICMED	Pkinase_Tyr	enzymatic activity, inhibited				3309512	1	0	0	mutation Y939F increases activity of Jak1 in vitro	
ELK1	DNA binding protein; Transcription factor	P19419	2002	ELK1	Xp11.2	human	S383	PHOSPHORYLATION	447872	IHFWSTLsPIAPRSP		activity, induced; molecular association, regulation; intracellular localization; protein conformation	transcription, induced; transcription, altered	AurA(INDUCES)	DNA(INDUCES)	27565316; 2270; 15630002; 6205	34	1	0		
NHE1	Membrane protein, integral; Membrane protein, multi-pass; Motility/polarity/chemotaxis; Transporter	P26431	24782	Slc9a1		rat	S707	PHOSPHORYLATION	448347	MSRARIGsDPLAYEP			apoptosis, induced			7977	6	40	184		
Lck	EC 2.7.10.2; KINASE; Kinase, protein; Protein kinase, TK; Protein kinase, tyrosine (non-receptor)	P06239	3932	LCK	1p34.3	human	Y192	PHOSPHORYLATION	447821	NLDNGGFyISPRITF	SH2	molecular association, regulation; activity, inhibited; phosphorylation				2243	2	20	1047	leads to lower ERK activation and less protein binding (pTyr proteins in lysates and pTyr peptides in vitro through Lck's SH2 domain)	
HNF4 alpha	DNA binding protein; Nuclear receptor; Transcription factor	P41235	3172	HNF4A	20q13.12	human	Y286	PHOSPHORYLATION	22996302	LQIDDNEyAYLKAII	Hormone_recep	protein degradation; intracellular localization; phosphorylation	transcription, inhibited			22958931	1	1	0	reduced nuclear localization and protein stability; multistep phosphorylation by Src, phosphorylating Y23 first, which interacts with the Src SH2 domain, followed by phosphorylation of Y286, Y288  	
FGFR3	EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Protein kinase, TK; Protein kinase, tyrosine (receptor)	P22607	2261	FGFR3	4p16.3	human	Y760	PHOSPHORYLATION	448117	TVTSTDEyLDLSAPF		molecular association, regulation; enzymatic activity, induced	cell growth, altered	SH2-B-beta(INDUCES)		2465; 1473	2	0	0		
survivin	Apoptosis	O15392	332	BIRC5	17q25	human	T117	PHOSPHORYLATION	450947	KNKIAKEtNNKKKEF		molecular association, regulation; intracellular localization	cell cycle regulation	INCENP(INDUCES)		3216; 11818	2	0	0		
NFM	Cytoskeletal protein	P08553	18040	Nefm		mouse	S502	PHOSPHORYLATION	448041	EEPEAEKsPVKSPEA			cytoskeletal reorganization			7072905	3	7	6	slightly altered axoplasmic organization in 7S/A mice mutant	
CYP2E1	EC 1.14.13.-; EC 1.14.13.n7; EC 1.14.14.1; Endoplasmic reticulum; Lipid Metabolism - arachidonic acid; Lipid Metabolism - linoleic acid; Mitochondrial; Oxidoreductase; Xenobiotic Metabolism - drug metabolism - cytochrome P450; Xenobiotic Metabolism - metabolism by cytochrome P450	P05182	25086	Cyp2e1		rat	S129	PHOSPHORYLATION	455561	WKDVRRFsLSILRDW	p450	molecular association, regulation		HSP70(INDUCES)		5454	2	5	1		
RIP140	Nuclear receptor co-regulator; Transcription, coactivator/corepressor	Q8CBD1	268903	Nrip1		mouse	Y436	PHOSPHORYLATION	25234801	SSGDESSySNCVPID		protein degradation; ubiquitination				25227607	1	0	1	regulates inflamatory responses and contributes to endotoxin tolerance	
NUP98 iso2	Motility/polarity/chemotaxis; Nucleoporin	P52948-2	4928	NUP98	11p15.5	human	S595	PHOSPHORYLATION	470432	LNNSNLFsPVNRDSE		intracellular localization				18331300	2	26	5	as multiple sites (13PM) mutant 	
DBNL	Actin binding protein; Motility/polarity/chemotaxis	Q62418	13169	Dbnl		mouse	Y350	PHOSPHORYLATION	450091	PPEQDTLyEEPPLVQ	PAT1		cytoskeletal reorganization			23260305	3	1	23	podosome dot, rosette formation, extracellular matrix degradation 	
NKCC2	Membrane protein, integral; Membrane protein, multi-pass; Transporter	P55016	25065	Slc12a1		rat	T101	PHOSPHORYLATION	458228	LQTFGHNtMDAVPKI	AA_permease_N	activity, induced; intracellular localization				7308; 2831757	7	2	0	observed in triple mutant T96/111/101A	
PPP2R5D	Motility/polarity/chemotaxis; Protein phosphatase, regulatory subunit	Q14738	5528	PPP2R5D	6p21.1	human	S60	PHOSPHORYLATION	457388	PSSNKRPsNSTPPPT		molecular association, regulation; phosphorylation	cell cycle regulation	PPP2CA(INDUCES)		9201	5	0	0	enhances dephosphorylation of Cdc25C	
CFTR	Channel, chloride; EC 3.6.3.49; Hydrolase; Membrane protein, integral; Membrane protein, multi-pass; Transporter	P13569	1080	CFTR	7q31.2	human	S790	PHOSPHORYLATION	2907510	IHRKTTAsTRKVSLA	CFTR_R	activity, induced				8384	2	0	0		
Akt1	EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor)	P47196	24185	Akt1		rat	T308	PHOSPHORYLATION	447856	KDGATMKtFCGTPEY	Pkinase		apoptosis, inhibited			4647107	462	2	12		
BLNK	Adaptor/scaffold	Q9YGC1	395733	BLNK		chicken	S170	PHOSPHORYLATION	7603529	LPRPKKPsLPSPAAK			transcription, altered			7543511	1	1	0		
Mnk2	EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, CAMK; Protein kinase, Ser/Thr (non-receptor); Translation	Q8CDB0	17347	Mknk2		mouse	T379	PHOSPHORYLATION	447642	APENTLPtPLVLQRN		enzymatic activity, induced				6207	1	1	0		
DRP1	Apoptosis; EC 3.6.5.5; Endoplasmic reticulum; Hydrolase; Microtubule binding protein; Mitochondrial; Motor protein	O35303	114114	Dnm1l		rat	S635	PHOSPHORYLATION	454690	PIPIMPAsPQKGHAV			cell cycle regulation			9372	9	36	112	promotes mitochondrial fission in mitosis	
PKR	EC 2.7.10.2; EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor); Translation	P19525	5610	EIF2AK2	2p22-p21	human	T90	PHOSPHORYLATION	3181643	SPLLLTTtNSSEGLS		enzymatic activity, induced				9075	1	1	0		
profilin 1	Actin binding protein; Cytoskeletal protein; Motility/polarity/chemotaxis	P07737	5216	PFN1	17p13.3	human	Y60	PHOSPHORYLATION	464066	GKDRSSFyVNGLTLG	Profilin	molecular association, regulation		ACTA1(INDUCES)		2831751	1	1	53		
ATP7B	EC 3.6.3.4; Hydrolase; Membrane protein, integral; Membrane protein, multi-pass; Transporter; Vesicle protein	P35670	540	ATP7B	13q14.3	human	S341	PHOSPHORYLATION	25786201	SGTDHRSsSSHSPGS		intracellular localization; protein conformation				25712644	1	0	0	 mutant does not return to TGN in response to copper depletion;  S340/341A mutant shifts ATP7B from trans-Golgi Network (TGN) to vesicles	
CD3G	Membrane protein, integral; Receptor, misc.	P09693	917	CD3G	11q23	human	S148	PHOSPHORYLATION	451430	GVRQSRAsDKQTLLP		receptor internalization, altered; activity, inhibited				3347; 3633	5	0	2	PKC mediated CD3G downregulation	
BCAP	Adaptor/scaffold	Q9EQ32	83490	Pik3ap1		mouse	Y420	PHOSPHORYLATION	450044	GEEADDVyESMAHLS		molecular association, regulation	cell differentiation, altered	PIK3R1(INDUCES)		12482418	2	0	9	regulate Akt activation and B-cell differentiation through binding to PI3KR1	
MAD2L1	Cell cycle regulation	Q13257	4085	MAD2L1	4q27	human	S195	PHOSPHORYLATION	468160	TTIHKVNsMVAYKIP	ATG13	molecular association, regulation; protein conformation; activity, inhibited	cell cycle regulation	Mad1(DISRUPTS); Cdc20(DISRUPTS)		10294003; 17431518	2	8	15	MAD2L1 S195D mutant bound to Mad1 with lower affinity in vitro but higher in vivo, as compared to MAD2L1-wt	
CASKIN1	Adaptor/scaffold	Q8VHK2	140722	Caskin1		rat	Y336	PHOSPHORYLATION	4274896	TGNDRVGyFPSSLGE	SH3_2	protein conformation				27257053	1	1	0	Phosphorylation leads to structural changes in the SH3 domain. 	
4E-BP1	Translation; Translation initiation	Q13541	1978	EIF4EBP1	8p12	human	T46	PHOSPHORYLATION	447496	GGTLFSTtPGGTRII	eIF_4EBP	molecular association, regulation; activity, inhibited; phosphorylation	translation, altered; cell growth, induced	eIF4E(DISRUPTS); 4E-BP1(DISRUPTS)		4805; 2063; 446; 7483316; 28854800; 6327; 29676408	90	20	90	T41 and T50 act as priming sites for T37/46	
TTK	Cancer Testis Antigen (CTA); EC 2.7.12.1; KINASE; Kinase, protein; Protein kinase, Other; Protein kinase, dual-specificity	P33981	7272	TTK	6q13-q21	human	S436	PHOSPHORYLATION	950200	VFSVSKQsPPISTSK			cytoskeletal reorganization			25082843	3	10	2	centrosome reduplication	
PAK1	EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, STE; Protein kinase, Ser/Thr (non-receptor)	Q13153	5058	PAK1	11q13-q14	human	S144	PHOSPHORYLATION	448170	SNSQKYMsFTDKSAE		intracellular localization; enzymatic activity, induced	cytoskeletal reorganization			5011220; 17675043	8	15	126	PAK activation induces PAK translocation, increased membrane permeability and MRLC1 phosphorylation. 
 	
Rb	Nuclear receptor co-regulator; Transcription, coactivator/corepressor; Tumor suppressor	P13405	19645	Rb1		mouse	S605	PHOSPHORYLATION	447977	MYLSPLRsPKKRTST		molecular association, regulation		E2F1(DISRUPTS)		1258	8	8	33		
eNOS	Amino Acid Metabolism - arginine and proline; EC 1.14.13.39; Oxidoreductase	Q62600	24600	Nos3		rat	T494	PHOSPHORYLATION	447885	TGITRKKtFKEVANA		enzymatic activity, inhibited				3342613; 1071	56	1	1		
Syk	EC 2.7.10.2; KINASE; Kinase, protein; Protein kinase, TK; Protein kinase, tyrosine (non-receptor)	P43405	6850	SYK	9q22	human	Y525	PHOSPHORYLATION	447661	ALRADENyYKAQTHG	Pkinase_Tyr	enzymatic activity, induced		ITGAM(INDUCES)		6782010; 759; 6482	18	4	76	ITAM peptide binding increases autophosphorylation of Syk.	
IKKB	EC 2.7.11.10; KINASE; Kinase, protein; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor)	O14920	3551	IKBKB	8p11.2	human	Y199	PHOSPHORYLATION	449633	ELLEQQKyTVTVDYW	Pkinase	activity, induced	transcription, altered			2269; 5591	4	0	0		
eIF4B	Translation; Translation initiation	P23588	1975	EIF4B	12q13.13	human	S422	PHOSPHORYLATION	451290	RERSRTGsESSQTGT		molecular association, regulation; activity, inhibited	translation, altered	eIF3-alpha(INDUCES)		2407102; 3513	4	21	455		
Rb	Nuclear receptor co-regulator; Transcription, coactivator/corepressor; Tumor suppressor	P06400	5925	RB1	13q14.2	human	K874	ACETYLATION	459027	NPPKPLKkLRFDIEG	Rb_C	molecular association, regulation; intracellular localization; phosphorylation	cell cycle regulation	E2F1(DISRUPTS)		7499; 7635	3	1	0	reduced level of CDK-dependent phosphorylation of Rb KK873/874QQ mutant; alters the distribution of Rb in the nucleus	
CACNA1C	Channel, calcium; Membrane protein, integral; Membrane protein, multi-pass	Q01815	12288	Cacna1c		mouse	S1487	PHOSPHORYLATION	460572	DYLTRDWsILGPHHL		activity, induced				14551419	4	0	0	mediates Ca2+ current facilitation 	
S6	Translation	P62753	6194	RPS6	9p21	human	S235	PHOSPHORYLATION	448092	IAKRRRLsSLRASTS	DUF4055	molecular association, regulation			RNA(INDUCES)	11812	131	26	946	7-methylguanosine cap	
CCNE1	Activator protein; Nuclear receptor co-regulator	P24864	898	CCNE1	19q12	human	T77	PHOSPHORYLATION	454411	DPCSLIPtPDKEDDD		protein degradation; molecular association, regulation		FBXW7(INDUCES)		4278; 4279; 11426	5	1	0		
PLK4	EC 2.7.11.21; KINASE; Kinase, protein; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor)	Q64702	20873	Plk4		mouse	T289	PHOSPHORYLATION	12654002	SMDSGHAtLSTTITA		protein degradation; ubiquitination				12525201	1	1	0		
HPK1	EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, STE; Protein kinase, Ser/Thr (non-receptor)	Q92918	11184	MAP4K1	19q13.1-q13.4	human	T165	PHOSPHORYLATION	455473	ISAQIGAtLARRLSF	Pkinase	enzymatic activity, induced	transcription, altered			5232	2	0	0		
CYLD	EC 3.1.2.15; EC 3.4.19.12; Protease; Ubiquitin conjugating system; Ubiquitin-specific protease	Q9NQC7	1540	CYLD	16q12.1	human	S418	PHOSPHORYLATION	4745557	TTENRFHsLPFSLTK		ubiquitination				12156302	2	12	22	induces ubiquitination of TRAF2	
MARK2	EC 2.7.11.1; EC 2.7.11.26; KINASE; Kinase, protein; Protein kinase, CAMK; Protein kinase, Ser/Thr (non-receptor)	CAB06295	60328	Mark2		rat	S91	PHOSPHORYLATION	26573803	IDKTQLNsSSLQKLF	Pkinase		cytoskeletal reorganization			25785412	1	0	0	neurite outgrowth	
BRAF	EC 2.7.1.37; EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, Ser/Thr (non-receptor); Protein kinase, TKL	Q04982	396239	BRAF		chicken	S365	PHOSPHORYLATION	450243	GQRDRSSsAPNVHIN		molecular association, regulation; enzymatic activity, inhibited		14-3-3 beta(INDUCES)		7878	7	14	30		
PSARL	Apoptosis; EC 3.4.21.105; Membrane protein, integral; Membrane protein, multi-pass; Mitochondrial; Protease	Q9H300	55486	PARL	3q27.1	human	T69	PHOSPHORYLATION	471331	PRRSDPGtSGEAYKR		protein processing				9119	1	1	0	involved in mitochondrial fragmentation	
NMDAR2C	Channel, calcium; Channel, ligand-gated; Membrane protein, integral; Membrane protein, multi-pass	Q01098	14813	Grin2c		mouse	S1084	PHOSPHORYLATION	7979604	GPRPRHAsLPSSVAE		intracellular localization	apoptosis, altered			7890601	1	0	0	important for cell survival	
DDR2	EC 2.7.1.112; EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Protein kinase, TK; Protein kinase, tyrosine (receptor)	Q16832	4921	DDR2	1q23.3	human	Y741	PHOSPHORYLATION	456863	NLYSGDYyRIQGRAV	Pkinase_Tyr	phosphorylation				6843	1	4	24	Stimulates autophosphorylation.  Autophosphorylation induces Shc binding (site not determined).	
AML1 iso8	DNA binding protein; Transcription factor	Q01196-8	861	RUNX1	21q22.3	human	S293	PHOSPHORYLATION	454400	QYLGSIAsPSVHPAT		protein degradation				9029; 6620	7	1	25	Phosphorylation promotes degradation via Cdc20-mediated pathways (Cdh1-mediated regardless of phosphorylation state).	
Snail1	C2H2-type zinc finger protein; Transcription factor	O95863	6615	SNAI1	20q13.2	human	S11	PHOSPHORYLATION	11493500	SFLVRKPsDPNRKPN		protein degradation; protein stabilization; molecular association, regulation; intracellular localization; activity, inhibited	carcinogenesis, altered; transcription, altered	14-3-3 sigma(INDUCES); SAP30(INDUCES)		11419352; 15785205	3	0	0		
PAK1	EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, STE; Protein kinase, Ser/Thr (non-receptor)	Q13153	5058	PAK1	11q13-q14	human	T423	PHOSPHORYLATION	448177	PEQSKRStMVGTPYW	Pkinase	molecular association, regulation; protein conformation; enzymatic activity, induced		Cdc42 iso1(INDUCES)		9987305; 2665610; 5011221; 9073	24	2	9	Binding of Cdc42 induces a PAK1 fully open active enzyme and phosphorylation of T423.;  substrate binding induces an intermediate-active state leading to autophosphorylation; unphosphorylated structure has an essentially active conformation	
p53	Activator protein; DNA binding protein; Motility/polarity/chemotaxis; Nuclear receptor co-regulator; Transcription factor; Tumor suppressor	P04637	7157	TP53	17p13.1	human	K381	UBIQUITINATION	464657	GQSTSRHkKLMFKTE		protein degradation; intracellular localization	transcription, inhibited			12136; 7920	11	0	0	K370/372/373/381/382/386/R mutant shows 613-fold activation of p53	
Ret	EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Protein kinase, TK; Protein kinase, tyrosine (receptor)	P07949	5979	RET	10q11.2	human	Y1062	PHOSPHORYLATION	447625	TWIENKLyGMSDPNW		molecular association, regulation; enzymatic activity, induced; phosphorylation	apoptosis, induced; apoptosis, inhibited; cytoskeletal reorganization; transcription, altered; cell growth, altered	Dok6(INDUCES); Crk(INDUCES); SHP-2(INDUCES); Shc3(INDUCES); Gab1(INDUCES); IRS1(INDUCES); Shc1(INDUCES); FRS2(INDUCES); Shc1(NOT_REPORTED); PKCA(INDUCES); RapGEF1(INDUCES); PIK3R1(INDUCES)		778; 15235208; 8770; 2670104; 6462; 2444; 8772; 8774; 2445; 2446; 3433; 6002; 6278; 8773; 6179; 1260; 5309411; 6410; 3487; 4762	36	0	2		
WAVE2	Actin binding protein; Motility/polarity/chemotaxis	Q9Y6W5	10163	WASF2	1p36.11	human	T346	PHOSPHORYLATION	18715502	VGFGSPGtPPPPSPP		molecular association, regulation	cell motility, altered; cytoskeletal reorganization			18668222	1	0	0	regulates WRC (WAVE2 regulatory complex) interaction with Arp2/3 and lamellipodial protrusion	
Shc3 iso2	Adaptor/scaffold; Motility/polarity/chemotaxis	Q92529-2	53358	SHC3	9q22.1	human	Y301	PHOSPHORYLATION	451259	PTGEAPTyVNTQQIP		activity, induced; molecular association, regulation; phosphorylation	transcription, altered	SOS1(INDUCES); DYN1(INDUCES); Grb2(INDUCES)		3475; 6724	3	0	1	ERK activation	
PDE4D iso2	EC 3.1.4.17; Nucleotide Metabolism - purine; Phosphodiesterase	Q08499-2	5144	PDE4D	5q12	human	S238	PHOSPHORYLATION	469621	KKLMHSSsLTNSSIP		enzymatic activity, induced				8256	1	6	6	switches the effect of S579 phosphorylation from inhibition to activation  	
RIP140	Nuclear receptor co-regulator; Transcription, coactivator/corepressor	Q8CBD1	268903	Nrip1		mouse	T207	PHOSPHORYLATION	455626	GPTLPDVtPNLIRDS		activity, induced				6686	3	2	0		
SMPD1	EC 3.1.4.12; Lipid Metabolism - sphingolipid; Phosphodiesterase	P17405	6609	SMPD1	11p15.4-p15.1	human	S508	PHOSPHORYLATION	477185	DGNYSGSsHVVLDHE		intracellular localization; enzymatic activity, induced				9374	2	0	0	increases synthesis of ceramide	
ACTN4	Cytoskeletal protein; Motility/polarity/chemotaxis	O43707	81	ACTN4	19q13	human	Y4	PHOSPHORYLATION	11498501	____MVDyHAANQSY		molecular association, regulation	cytoskeletal reorganization; cell growth, altered	ACTA1(DISRUPTS)		11419364	1	0	0	F-actin binding	
CARD11	Adaptor/scaffold	Q9BXL7	84433	CARD11	7p22	human	S116	PHOSPHORYLATION	466431	KEPTRRFsTIVVEEG		molecular association, regulation		Bcl-10(INDUCES)		8145	1	0	1		
DARPP-32	Motility/polarity/chemotaxis; Protein phosphatase, regulatory subunit	Q6J4I0	360616	Ppp1r1b		rat	T34	PHOSPHORYLATION	448047	MIRRRRPtPALLFRV	DARPP-32; Drc1-Sld2; SPX; PPP4R2; Nucleoplasmin		transcription, altered	PPP1CA(INDUCES)		4017; 11554706	53	4	43	Cocaine sensitized rats showed increased phosphorylation at T75 and decreased at T34, as well as increased Cdk5 expression. 	
Akt1	EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor)	P31750	11651	Akt1		mouse	T308	PHOSPHORYLATION	447856	KDGATMKtFCGTPEY	Pkinase	activity, induced; protein degradation; molecular association, regulation; ubiquitination; enzymatic activity, induced	apoptosis, altered; apoptosis, inhibited; cytoskeletal reorganization; cell growth, altered	HSP90A(NOT_REPORTED); CHIP(INDUCES)		6552; 4534; 14148607; 22433506; 1066007; 449; 7550836	462	2	12		
Src iso2	EC 2.7.10.2; KINASE; Kinase, protein; Protein kinase, TK; Protein kinase, tyrosine (non-receptor)	NP_001020566	20779	Src		mouse	Y138	PHOSPHORYLATION	450213	TGYIPSNyVAPSDSI			cell cycle regulation; cell growth, altered			2708	2	0	0		
TNNI3	Actin binding protein; Motility/polarity/chemotaxis; Motor protein	P48787	21954	Tnni3		mouse	S43	PHOSPHORYLATION	450690	AKKKSKIsASRKLQL		activity, induced; activity, inhibited; protein conformation	cell motility, altered; cytoskeletal reorganization			13320406; 3084; 7889902; 4862627; 4862629; 8954; 4862628	18	1	0		
PHOX2A	DNA binding protein; Transcription factor	O14813	401	PHOX2A	11q13.2	human	S206	PHOSPHORYLATION	9400300	GLASPRLsPSPLPVA		molecular association, regulation; phosphorylation	transcription, inhibited		DNA(DISRUPTS)	9158113	1	1	0	regulates phosphorylation of PHOX2A S153; inhibits neuronal differentiation	
ERR3	DNA binding protein; Nuclear receptor; Transcription factor	P62508	2104	ESRRG	1q41	human	S45	PHOSPHORYLATION	1725304	FIKTEPSsPASLTDS		sumoylation	transcription, inhibited			5930024	2	0	0		
GSK3A	EC 2.7.11.1; EC 2.7.11.26; KINASE; Kinase, protein; Protein kinase, CMGC; Protein kinase, Ser/Thr (non-receptor)	P18265	50686	Gsk3a		rat	S21	PHOSPHORYLATION	448584	SGRARTSsFAEPGGG		enzymatic activity, inhibited	apoptosis, altered			687; 20655007	122	11	274	phosphorylation decreases apoptosis	
MEF2C	DNA binding protein; Transcription factor	Q8CFN5	17260	Mef2c		mouse	S59	PHOSPHORYLATION	447999	NKLFQYAsTDMDKVL	SRF-TF		transcription, induced			1161	1	0	0		
GSTP1	EC 2.5.1.18; Other Amino Acids Metabolism - glutathione; Transferase; Xenobiotic Metabolism - drug metabolism - cytochrome P450; Xenobiotic Metabolism - metabolism by cytochrome P450	P09211	2950	GSTP1	11q13	human	S43	PHOSPHORYLATION	455117	VETWQEGsLKASCLY	GST_N	activity, induced				4355	1	1	0		
PTEN	Carbohydrate Metabolism - inositol phosphate; EC 3.1.3.16; EC 3.1.3.48; EC 3.1.3.67; Motility/polarity/chemotaxis; Nuclear receptor co-regulator; PHOSPHATASE; Phosphatase, lipid; Tumor suppressor	P60484	5728	PTEN	10q23.3	human	T382	PHOSPHORYLATION	448314	DHYRYSDtTDSDPEN		molecular association, regulation; protein stabilization; enzymatic activity, inhibited	cell differentiation, altered; cell motility, altered; transcription, altered	PTEN(DISRUPTS); AIP1(DISRUPTS)		1252602; 767; 2670102; 6416; 2904	11	2	0	cell migration in embryo	
desmoplakin 3	Cytoskeletal protein; Motility/polarity/chemotaxis	P14923	3728	JUP	17q21	human	Y644	PHOSPHORYLATION	456973	RNEGTATyAAAVLFR	Arm	molecular association, regulation	transcription, induced	desmoplakin(INDUCES); CTNNA1(DISRUPTS); CDH1(DISRUPTS)		5375	1	1	27		
TIE2	EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Protein kinase, TK; Protein kinase, tyrosine (receptor)	Q02763	7010	TEK	9p21	human	Y897	PHOSPHORYLATION	459394	GACEHRGyLYLAIEY	Pkinase_Tyr	enzymatic activity, inhibited				8847	1	0	25		
CPLX1	Vesicle protein	Q0IIL7	768228	CPLX1		cow	S115	PHOSPHORYLATION	474557	AAEEEDEsILDTVIK	Synaphin; DUF4407	molecular association, regulation		STX1A(INDUCES)		9272	2	1	1	SNARE complex summarized by Syntaxin binding.	
CFTR	Channel, chloride; EC 3.6.3.49; Hydrolase; Membrane protein, integral; Membrane protein, multi-pass; Transporter	P13569	1080	CFTR	7q31.2	human	S641	PHOSPHORYLATION	2907508	QNLQPDFsSKLMGCD	CFTR_R	activity, induced; activity, inhibited				8384; 8371	2	0	0		
RASSF1 iso2	Tumor suppressor	Q9NS23-2	11186	RASSF1	3p21.3	human	S203	PHOSPHORYLATION	484000	TSVRRRTsFYLPKDA	RA	protein degradation; molecular association, regulation; ubiquitination	cell cycle regulation; apoptosis, altered; apoptosis, inhibited; cytoskeletal reorganization; transcription, altered	TUBA1A(DISRUPTS); SKP2(INDUCES); Cdc20(DISRUPTS)		25227600; 15331037; 12007; 7313816; 1713128	8	5	1	APC/C-dependent ubiquitination of RASSF1	
EphA2	EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Protein kinase, TK; Protein kinase, tyrosine (receptor)	P29317	1969	EPHA2	1p36	human	Y735	PHOSPHORYLATION	473293	KYLANMNyVHRDLAA	Pkinase_Tyr	molecular association, regulation	cell differentiation, altered; cell motility, altered	PIK3R1(INDUCES)		4254811	1	3	11		
claudin 1	Cytoskeletal protein; Membrane protein, integral; Membrane protein, multi-pass	O88551	12737	Cldn1		mouse	T203	PHOSPHORYLATION	451428	PRPYPKPtPSSGKDY		intracellular localization				3629	1	0	0		
FOXC2	Apoptosis; Cell development/differentiation; DNA binding protein; Transcription factor	Q99958	2303	FOXC2	16q24.1	human	S219	PHOSPHORYLATION	3210576	VIKSEAAsPALPVIT		molecular association, regulation	transcription, altered		DNA(INDUCES)	28129300	1	7	1	implicated in vascular remodeling  in vivo	
Dok7	Activator protein; Adaptor/scaffold	Q18PE0	231134	Dok7		mouse	Y396	PHOSPHORYLATION	17535701	CPPGAAEyQVPTSLR		molecular association, regulation; phosphorylation		Crk(INDUCES); CrkL(INDUCES); MuSK(INDUCES)		17482903	1	1	0	 plays an important role in AChR clustering; stimulates MuSK and AChR phosphorylation	
ARAF	EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, Ser/Thr (non-receptor); Protein kinase, TKL	P10398	369	ARAF	Xp11.4-p11.2	human	S214	PHOSPHORYLATION	3180426	LQRIRSTsTPNVHMV		enzymatic activity, induced				3301229	1	3	22		
LEF-1	DNA binding protein; Transcription factor	Q9UJU2	51176	LEF1	4q23-q25	human	T155	PHOSPHORYLATION	11499001	SHAVHPLtPLITYSD	CTNNB1_binding		transcription, inhibited			10294002	1	0	10		
myogenin	DNA binding protein; Transcription factor	P12979	17928	Myog		mouse	T87	PHOSPHORYLATION	451161	VDRRRAAtLREKRRL	DUF3080; HLH	activity, induced				3354	1	0	0	affects muscle innervation rates	
ATP12A	EC 3.6.3.10; Energy Metabolism - oxidative phosphorylation; Hydrolase; Membrane protein, integral; Membrane protein, multi-pass; Transporter	P54708	171028	Atp12a		rat	S955	PHOSPHORYLATION	465553	IRKTRRNsIFQQGLF	Cation_ATPase_C	activity, induced; protein stabilization; intracellular localization				7967	1	0	0	important for transporter functions	
SYN2	Vesicle protein	Q64332	20965	Syn2		mouse	S10	PHOSPHORYLATION	449839	NFLRRRLsDSSFIAN	Synapsin_N	intracellular localization				2855902	6	2	0	Mutation S10A synapsin inhibits basal cell surface  Glut4 four-fold.	
Kv1.3	Channel, potassium; Membrane protein, integral; Membrane protein, multi-pass	P22001	3738	KCNA3	1p13.3	human	Y163	PHOSPHORYLATION	3820936	FDAILYYyQSGGRIR	K_tetra	activity, inhibited				6331318	1	0	0		
occludin	Cell adhesion; Membrane protein, integral; Membrane protein, multi-pass; Motility/polarity/chemotaxis	Q91049		OCLN		chicken	Y383	PHOSPHORYLATION	458611	ESQYETDyTTAVESS		molecular association, regulation; intracellular localization		ZO1(INDUCES)		5354427	1	4	6		
ITGB3	Cell adhesion; Membrane protein, integral; Motility/polarity/chemotaxis	P05106	3690	ITGB3	17q21.32	human	Y785	PHOSPHORYLATION	448013	STFTNITyRGT____	Integrin_b_cyt	molecular association, regulation; protein processing; activity, inhibited	cytoskeletal reorganization; cell adhesion, altered	Shc1(INDUCES); kindlin-2(DISRUPTS); tensin 1(NOT_REPORTED); Grb2(INDUCES)		5188; 4750; 1839; 2848001; 2512002; 1133; 15658712	16	2	6		
K8	Cytoskeletal protein	P05787	3856	KRT8	12q13	human	S432	PHOSPHORYLATION	448540	SAYGGLTsPGLSYSL		intracellular localization	cell motility, altered; cytoskeletal reorganization			1030; 6277007	20	2	20		
Wee1	EC 2.7.10.2; KINASE; Kinase, protein; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor)	P30291	7465	WEE1	11p15.3-p15.1	human	S121	PHOSPHORYLATION	456468	WEEEGFGsSSPVKSP		protein degradation; molecular association, regulation		BTRC(INDUCES)		6704	2	0	0		
ITCH	EC 6.3.2.-; EC 6.3.2.19; Ligase; UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase	Q8C863	16396	Itch		mouse	T222	PHOSPHORYLATION	459624	PSRPPPPtPRRPASV		protein stabilization; protein conformation				7638	1	0	0		
IEX-1	Apoptosis; Membrane protein, integral	P46695	8870	IER3	6p21.3	human	T18	PHOSPHORYLATION	455559	MTILQAPtPAPSTIP			apoptosis, inhibited			5443	1	1	0		
MAIR-I	Immunoglobulin superfamily; Membrane protein, integral	Q7TSN3	217303	Cd300a		mouse	Y262	PHOSPHORYLATION	455226	SQVEVVEySTLALPQ	Cytadhesin_P30	molecular association, regulation		SHIP(INDUCES); SHP-2(INDUCES); SHP-1(INDUCES)		4443	1	0	7		
PAK1	EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, STE; Protein kinase, Ser/Thr (non-receptor)	Q13153	5058	PAK1	11q13-q14	human	Y201	PHOSPHORYLATION	487519	PEHTKSVyTRSVIEP		enzymatic activity, induced	apoptosis, altered; cell motility, induced; cell motility, altered			27519665; 12246	4	0	0	membrane ruffling;  closure of wounded monolayer; JAK2 tyrosine phosphorylation of PAK1 protects against apoptosis, and is required for maximal cell motility. 	
USP28	EC 3.1.2.15; EC 3.4.19.12; Protease; Ubiquitin-specific protease	Q96RU2	57646	USP28	11q23	human	S67	PHOSPHORYLATION	467252	DERVKEPsQDTVATE			apoptosis, altered			8181	1	2	0		
DAB1	Adaptor/scaffold	O75553	1600	DAB1	1p32-p31	human	Y220	PHOSPHORYLATION	447630	PETEENIyQVPTSQK		molecular association, regulation		Crk(INDUCES)		6167	11	2	0		
RIPK1	EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, Ser/Thr (non-receptor); Protein kinase, TKL	Q13546	8737	RIPK1	6p25.2	human	S161	PHOSPHORYLATION	20536001	IADLGLAsFKMWSKL	Pkinase_Tyr	enzymatic activity, induced				25779417	1	1	0	necroptosis regulation	
Rad51	DNA repair; Mitochondrial	Q06609	5888	RAD51	15q15.1	human	S14	PHOSPHORYLATION	23305001	LEANADTsVEEESFG		phosphorylation	DNA repair, induced			23260334	1	1	0	stimulates CK2-mediated phosphorylation of Rad51 T13 ; involved in DNA damage recognition and homologous recombination (HR) repair	
KCNN4	Channel, potassium; Membrane protein, integral; Membrane protein, multi-pass	Q9QYW1	65206	Kcnn4		rat	S332	PHOSPHORYLATION	452145	KHTRRKDsRAARRHQ	CaMBD	activity, inhibited				4074	2	0	0		
Gab1	Adaptor/scaffold; Motility/polarity/chemotaxis	Q13480	2549	GAB1	4q31.21	human	Y627	PHOSPHORYLATION	447948	KGDKQVEyLDLDLDS		molecular association, regulation; phosphorylation	cell cycle regulation	SYP(INDUCES); SHP-2(INDUCES); PIK3R1(INDUCES)		685; 2319; 1103; 4602	14	12	412	Binding of SHP-2 to Gab1 leads to ERK activation.	
KCNJ2	Channel, potassium; Membrane protein, integral; Membrane protein, multi-pass	P63252	3759	KCNJ2	17q24.3	human	S425	PHOSPHORYLATION	10892807	PRPLRREsEI_____		activity, inhibited				10895300	1	0	0	reduces an inward rectifier current of Kir2.1 V227F	
GluR1	Channel, calcium; Channel, ligand-gated; Membrane protein, integral; Membrane protein, multi-pass	P42261	2890	GRIA1	5q31.1	human	S834	PHOSPHORYLATION	9486201	EFCYKSRsESKRMKG		molecular association, regulation; intracellular localization		EPB41L1(INDUCES)		9158103	1	0	0	enhances receptor insertion into plasma membrane	
PACSIN1	Adaptor/scaffold	Q61644	23969	Pacsin1		mouse	S358	PHOSPHORYLATION	4730500	QTYATEWsDDESGNP		molecular association, regulation	cytoskeletal reorganization	RAC1(INDUCES)		27619341	1	4	1	dendritic spine formation;  S358 phosphorylation disrupts PACSIN1-ARHGAP17-Rac complex which is essential for Rac1 hydrolysis. 	
PKAR1A	Protein kinase, regulatory subunit	P10644	5573	PRKAR1A	17q23-q24	human	S77	PHOSPHORYLATION	468450	KAGTRTDsREDEISP		molecular association, regulation				28723105	1	17	27	decreased affinity for cAMP	
MAP4	Cytoskeletal protein; Motility/polarity/chemotaxis	P27816	4134	MAP4	3p21	human	S787	PHOSPHORYLATION	448480	KAPEKRAsPSKPASA		activity, inhibited	cytoskeletal reorganization			1478	2	17	5	reduced microtubule polymerization activity	
TIF1B	EC 6.3.2.-; KINASE; Kinase, protein; Ligase; Nuclear receptor co-regulator; Protein kinase, ATYPICAL; Protein kinase, atypical; Transcription, coactivator/corepressor; UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase	Q13263	10155	TRIM28	19q13.4	human	Y458	PHOSPHORYLATION	454817	FGSGDDPySSAEPHV		molecular association, regulation; phosphorylation	DNA repair, induced	HP1 alpha(INDUCES)	DNA(NOT_REPORTED)	27959900	1	8	104	stimulates phosphorylation of TIF1B S473 and TIF1B S824 in DNA damage response; involved in DNA damage response; inhibits association of HP1alpha with chromatin	
ER-alpha	DNA binding protein; Nuclear receptor	P03372	2099	ESR1	6q25.1	human	S47	PHOSPHORYLATION	12127400	GEVYLDSsKPAVYNY	Oest_recep	activity, induced	transcription, altered			12021304	1	0	0		
DRD3	GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR	P35462	1814	DRD3	3q13.3	human	S257	PHOSPHORYLATION	482886	LELKRYYsICQDTAL	7tm_1	receptor desensitization, altered; receptor internalization, altered		FLNA(INDUCES)		11766	1	0	0		
Jun	Transcription factor	P05412	3725	JUN	1p32-p31	human	T93	PHOSPHORYLATION	450449	GHITTTPtPTQFLCP	Jun	molecular association, regulation	carcinogenesis, altered; transcription, altered; cell growth, altered		DNA(DISRUPTS)	4843006; 7397639; 17675043	8	0	0		
NFAT5	Transcription factor	O94916	10725	NFAT5	16q22.1	human	S134	PHOSPHORYLATION	6223353	NTVQQHPsTPKRHTV		intracellular localization				18021001	1	1	2		
IRS1	Adaptor/scaffold; Motility/polarity/chemotaxis	P35568	3667	IRS1	2q36	human	S616	PHOSPHORYLATION	447562	DDGYMPMsPGVAPVP		intracellular localization; activity, inhibited				7325701; 8915	30	4	3	via cell fractionation experiments; Phosphorylated S616 results in an inhibition of insulin signaling.	
NUMB	Cell development/differentiation; Tumor suppressor	Q9QZS3	18222	Numb		mouse	S295	PHOSPHORYLATION	470030	SPFKRQLsLRINELP	NumbF	molecular association, regulation	endocytosis, induced; cell motility, induced	TrkA(INDUCES)		21588900	4	2	17		
ANXA2	Calcium-binding protein; Lipid binding protein; Motility/polarity/chemotaxis	Q6TEQ7	403435	ANXA2		dog	Y24	PHOSPHORYLATION	449483	HSTPPSAyGSVKAYT			cell motility, altered; cytoskeletal reorganization			1713125	7	34	2601	 involved in the ROCK/LIMK-dependent dephosphorylation/activation of cofilin; regulates F-actin organization and dynamics	
NFAT5	Transcription factor	D3ZGB1		Nfat5		rat	Y160	PHOSPHORYLATION	12127405	PKRHTVLyISPPPED		activity, induced; intracellular localization	transcription, induced			14784601	4	1	0		
Kv1.5	Channel, potassium; Membrane protein, integral; Membrane protein, multi-pass	P22460	3741	KCNA5	12p13	human	T15	PHOSPHORYLATION	465994	LENGGAMtVRGGDEA		activity, induced				8111	1	0	0	required for SAP97-mediated increases in the channel currents	
Bcl-2	Apoptosis; Autophagy; Membrane protein, integral	P10417	12043	Bcl2		mouse	S84	PHOSPHORYLATION	448396	ATAGPALsPVPPVVH		protein stabilization; protein conformation	cell cycle regulation; apoptosis, inhibited			4558	17	0	0		
PHB	Apoptosis; Cell cycle regulation; Chaperone; Mitochondrial; Motility/polarity/chemotaxis; Transcription, coactivator/corepressor	P35232	5245	PHB	17q21	human	T258	O-GlcNAc	6374002	LSRSRNItYLPAGQS		phosphorylation				6331325	1	0	0		
eEF-2	Translation; Translation elongation	P58252	13629	Eef2		mouse	T57	PHOSPHORYLATION	448040	RAGETRFtDTRKDEQ	GTP_EFTU		translation, altered			6011111	24	25	48	induces Arc/Arg 3.1 translation 	
Chk2	EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, CAMK; Protein kinase, Ser/Thr (non-receptor)	O96017	11200	CHEK2	22q12.1	human	T383	PHOSPHORYLATION	447545	GETSLMRtLCGTPTY	Pkinase	ubiquitination; intracellular localization; protein conformation; enzymatic activity, induced				2452301; 15658725; 2236; 1025	6	1	2		
JAK2	EC 2.7.10.2; KINASE; Kinase, protein; Protein kinase, TK; Protein kinase, tyrosine (non-receptor)	Q62120	16452	Jak2		mouse	Y913	PHOSPHORYLATION	3345200	QHDNIVKyKGVCYSA	Pkinase_Tyr	enzymatic activity, inhibited	cell growth, altered			3309512	1	0	0	mutation Y913F increases activity of Jak2 in vitro	
BDP1	EC 3.1.3.48; Motility/polarity/chemotaxis; Protein phosphatase, tyrosine (non-receptor)	Q99952	26469	PTPN18	2q21.1	human	Y354	PHOSPHORYLATION	450261	GHAMADTyAVVQKRG		molecular association, regulation		TEC(INDUCES)		2955	1	0	0		
SPRY2	Adaptor/scaffold; Inhibitor protein; Motility/polarity/chemotaxis	O43597	10253	SPRY2	13q31.1	human	S121	PHOSPHORYLATION	465676	VSSGSRSsTRTSTSS		molecular association, regulation; protein stabilization; ubiquitination		BRAF(DISRUPTS); NEDD4 iso4(INDUCES)		11189922; 9983601; 8112	3	1	0	phosphorylation of this site stabilizes protein by interfering with Y55 phosphorylation, Cbl binding and polyubiquitination ; B-Raf V600E oncogenic mutant does not associate with Spry2 (altered kinase domain conformation); interaction with NEDD4 increases the ubiquitination of Spry2	
BRIP1	EC 3.6.1.-; EC 3.6.4.13; Helicase	Q9BX63	83990	BRIP1	17q22.2	human	S990	PHOSPHORYLATION	451461	IVISRSTsPTFNKQT		molecular association, regulation	cell cycle regulation	BRCA1(NOT_REPORTED); BRCA1(INDUCES)		13826401; 3987; 3653	4	3	0		
PINX1	Inhibitor protein	Q96BK5	54984	PINX1	8p23	human	T317	PHOSPHORYLATION	14823404	EDATLEEtLVKKKKK		protein degradation; ubiquitination				14790317	1	1	0		
G6b	Immunoglobulin superfamily; Membrane protein, integral; Receptor, misc.	O95866	80739	G6B	6p21.33	human	Y211	PHOSPHORYLATION	10296403	DQEPSLLyADLDHLA		molecular association, regulation		CSK(INDUCES); Syk(INDUCES); Src(INDUCES); SHP-2(INDUCES); SHP-1(INDUCES); Fyn(INDUCES); PLCG2(INDUCES); PIK3CA(INDUCES)		27257055; 12482250	2	1	4	 little or no association with the individual Y211 or Y237 phosphopeptides; 

~70% shifting from the unbound to the bound SHP-2 fraction for the dual phosphopeptide, and ~50% and ~25% binding to the Y211 and Y237 phosphopeptides, respectively; Only ~30% of the tandem SH2 domains of SHP-1 bound to the dual phosphopeptide	
GLI1	C2H2-type zinc finger protein; Transcription factor	P08151	2735	GLI1	12q13.2-q13.3	human	T374	PHOSPHORYLATION	457674	PGCTKRYtDPSSLRK	zf-C2H2	intracellular localization; activity, inhibited	transcription, altered			7317	1	0	0	phosphorylation of this site inhibits the transport of GLI1 to the nucleus 	
ataxin-3	DNA repair; EC 3.4.19.12; EC 3.4.22.-; Protease; Transcription regulation; Ubiquitin-specific protease	Q9CVD2	110616	Atxn3		mouse	S29	PHOSPHORYLATION	13421402	LLQGEYFsPVELSSI	Josephin	intracellular localization				13359111	1	1	0		
SIRT1	Apoptosis; DEACETYLASE; Deacetylase; EC 3.5.1.-; Nuclear receptor co-regulator	Q96EB6	23411	SIRT1	10q21.3	human	S47	PHOSPHORYLATION	452899	DGPGLERsPGEPGGA		intracellular localization; enzymatic activity, induced				12021300	3	20	7		
ATP7A	Apoptosis; Cell development/differentiation; Chaperone; EC 3.6.3.4; Hydrolase; Membrane protein, integral; Membrane protein, multi-pass; Transporter; Vesicle protein	Q04656	538	ATP7A	Xq21.1	human	S1432	PHOSPHORYLATION	4733392	QIGQKSPsEISVHVG		intracellular localization				9721215	1	3	0	required for post-Golgi exocytic trafficking (Cu -responsive)	
ICAM1	Cell adhesion; Immunoglobulin superfamily; Membrane protein, integral	P05362	3383	ICAM1	19p13.3-p13.2	human	Y512	PHOSPHORYLATION	450460	RQRKIKKyRLQQAQK		molecular association, regulation; protein processing	cell motility, altered; cell adhesion, altered	SHP-2(INDUCES)		3008; 3208; 3234	5	0	1		
HDAC7	EC 3.5.1.98; Hydrolase	Q8WUI4	51564	HDAC7	12q13.1	human	S486	PHOSPHORYLATION	452459	RPLSRAQsSPAAPAS		intracellular localization	cell motility, altered; cytoskeletal reorganization; transcription, altered; cell growth, altered			7397635; 3886811; 5506	6	9	56	important for VEGF-induced aorta ring angiogenesis; nucleo-cytoplasmic shuttling	
PLK4	EC 2.7.11.21; KINASE; Kinase, protein; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor)	Q64702	20873	Plk4		mouse	S285	PHOSPHORYLATION	12654000	TVEDSMDsGHATLST		protein degradation; ubiquitination				12525201	1	1	0		
NKEF-A	EC 1.11.1.15; Oxidoreductase	Q06830	5052	PRDX1	1p34.1	human	Y194	PHOSPHORYLATION	448924	DVQKSKEyFSKQK__	1-cysPrx_C	molecular association, regulation; intracellular localization; enzymatic activity, inhibited		NOX1(INDUCES)		12778822	1	6	143		
mGluR2	GPCR, family 3; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR	P31421	24415	Grm2		rat	S843	PHOSPHORYLATION	450654	GSAAPRAsANLGQGS		molecular association, regulation; activity, inhibited		GNA15(DISRUPTS)		3105	1	0	0		
IRF7	DNA binding protein; Transcription factor	P70434	54123	Irf7		mouse	S431	PHOSPHORYLATION	1276101	VSSLDSSsLGLCLSS			transcription, induced		DNA(INDUCES)	12173	4	0	0		
CRYAB	Chaperone	P23928	25420	Cryab		rat	S45	PHOSPHORYLATION	448748	FSTATSLsPFYLRPP	Crystallin		apoptosis, altered			5553	24	6	1		
TRPC7	Channel, calcium; Membrane protein, integral; Membrane protein, multi-pass	Q9WVC5	26946	Trpc7		mouse	T15	PHOSPHORYLATION	11164436	KNMQRRHtTLREKGR		activity, inhibited				19074804	1	0	4	calcium influx inhibited 	
NMT1	EC 2.3.1.97; Motility/polarity/chemotaxis; Transferase	P30419	4836	NMT1	17q21.31	human	Y180	PHOSPHORYLATION	10336300	YTLLNENyVEDDDNM	NMT	molecular association, regulation; enzymatic activity, induced		Lyn(INDUCES)		10167102	1	0	0		
GCH1	Cofactor and Vitamin Metabolism - folate biosynthesis; EC 3.5.4.16; Hydrolase	P22288	29244	Gch1		rat	S72	PHOSPHORYLATION	487495	AYSSILRsLGEDPQR		enzymatic activity, induced				10353908	4	0	0		
GEM	G protein; G protein, monomeric, RGK	P55040	2669	GEM	8q13-q21	human	S23	PHOSPHORYLATION	2060100	QPQQQRWsIPADGRH		protein stabilization; molecular association, regulation	cytoskeletal reorganization; cell adhesion, altered	14-3-3 beta(INDUCES)		3061	1	6	2	Mutation of either S23 or  S289 inhibits binding to 14-3-3	
RRM2B	EC 1.17.4.1; Nucleotide Metabolism - purine; Nucleotide Metabolism - pyrimidine; Other Amino Acids Metabolism - glutathione; Oxidoreductase	Q7LG56	50484	RRM2B	8q23.1	human	S72	PHOSPHORYLATION	5014902	TAEEVDLsKDLPHWN	Ribonuc_red_sm	protein stabilization; ubiquitination	cell cycle regulation			4960707	1	0	0	S72A-RRM2B mutant is hyperubiquitinated in UV-irradiated cells	
AKAP12	Adaptor/scaffold	Q5QD51	83425	Akap12		rat	S507	PHOSPHORYLATION	469987	SPLKKLFsSSGLKKL		molecular association, regulation	cell cycle regulation	CCNE1(DISRUPTS); CCND1(DISRUPTS)		8827; 8828	1	6	1	shown with PKC phosphorylated and nonphosphorylated AKAP12; in vivo permeable peptide/phosphopeptide experiments	
SNAP23	Vesicle protein	O00161	8773	SNAP23	15q14	human	S23	PHOSPHORYLATION	9766096	ITDESLEsTRRILGL	Prominin; DUF1664; V-SNARE_C	molecular association, regulation		STX4(INDUCES)		11484400	1	2	1		
GCSFR	Membrane protein, integral; Receptor, cytokine	Q99062	1441	CSF3R	1p35-p34.3	human	Y752	PHOSPHORYLATION	451834	GTSDQVLyGQLLGSP		molecular association, regulation; phosphorylation		SOCS3(INDUCES); CISH(INDUCES)		8404; 2670113; 3302	4	0	0	decreases ERK phosphorylation	
CARD11	Adaptor/scaffold	Q5F3W0	416476	RCJMB04_5k17		chicken	S668	PHOSPHORYLATION	457639	LERPFRPsVTSVGRI		molecular association, regulation		Bcl-10(INDUCES); MALT1(INDUCES)		17675049; 1713142	4	0	0	stimulates CBM complex formation, NF-kB activation and IL-2 or IFN-gamma production 	
MITF iso8	DNA binding protein; Transcription factor	Q08874-8	17342	Mitf		mouse	S73	PHOSPHORYLATION	450264	PGSSAPNsPMAMLTL		molecular association, regulation	transcription, inhibited	PIAS3(INDUCES)		8644	16	0	0		
BORA	Activator protein	Q6PGQ7	79866	BORA	13q22.1	human	S278	PHOSPHORYLATION	27724403	PISSPTFsPIEFQIG		protein degradation; molecular association, regulation	cell cycle regulation	Pin1(INDUCES)		28722159; 27623410	2	2	0	required for mitotic entry	
PIK3C3	Autophagy; Carbohydrate Metabolism - inositol phosphate; EC 2.7.1.137; Kinase, lipid; Motility/polarity/chemotaxis	Q8NEB9	5289	PIK3C3	18q12.3	human	T668	PHOSPHORYLATION	14662701	ENLDLKLtPYKVLAT	DUF4135; PI3_PI4_kinase	enzymatic activity, inhibited				14551424	1	0	0		
GTF2I iso2	DNA binding protein; Transcription, coactivator/corepressor	P78347-2	2969	GTF2I	7q11.23	human	Y248	PHOSPHORYLATION	448250	EESEDPDyYQYNIQG		molecular association, regulation	cell cycle regulation; transcription, induced; transcription, altered	ERK1(INDUCES)		8846; 1721; 1720; 1722	8	2	11		
PPAR-alpha	DNA binding protein; Nuclear receptor	P37230	25747	Ppara		rat	T129	PHOSPHORYLATION	457548	CKGFFRRtIRLKLAY	zf-C4	activity, induced; molecular association, regulation; intracellular localization	transcription, induced; transcription, altered	RXRA(INDUCES)	DNA(INDUCES)	7128; 21686203	2	0	0		
CD200R	Membrane protein, integral; Receptor, misc.	Q9ES57	57781	Cd200r1		mouse	Y286	PHOSPHORYLATION	458378	EEDEMQPyASYTEKS		molecular association, regulation		Dok2(INDUCES); Dok1(INDUCES)		7402	1	0	2		
IL22RA1	Membrane protein, integral	Q8N6P7	58985	IL22RA1	1p36.11	human	Y251	PHOSPHORYLATION	15512803	AVLCYLSyRYVTKPP		molecular association, regulation		SHP-2(INDUCES)		15235209	1	0	0	necessary for IL22RA1 to mediate the IL-22-stimulated MAP kinases and STAT3 activation	
TXA2-R iso2	GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR	P21731-2	6915	TBXA2R	19p13.3	human	S145	PHOSPHORYLATION	469630	FSRPAVAsQRRAWAT	7tm_1	receptor desensitization, altered				8248	2	0	0		
CD45	EC 3.1.3.48; Membrane protein, integral; Motility/polarity/chemotaxis; PHOSPHATASE; Receptor protein phosphatase, tyrosine	P06800	19264	Ptprc		mouse	S991	PHOSPHORYLATION	449973	SEPESDEsSDDDSDS	Y_phosphatase	enzymatic activity, induced				2533	1	1	0		
p73	DNA binding protein; Transcription factor	O15350	7161	TP73	1p36.3	human	Y99	PHOSPHORYLATION	448428	SVPTHSPyAQPSSTF		activity, induced	apoptosis, induced; transcription, altered	Bub3(INDUCES)		15031335; 1216	5	0	0	caspase-independent mitotic death (CIMD)   	
AS160	GTPase activating protein, Rab	O60343	9882	TBC1D4	13q22.2	human	S318	PHOSPHORYLATION	455925	EFRSRCSsVTGVQRR	PID	molecular association, regulation		14-3-3 epsilon(INDUCES)		14058615	9	5	316	multiple sites (6P) mutant	
Gab1	Adaptor/scaffold; Motility/polarity/chemotaxis	Q13480	2549	GAB1	4q31.21	human	Y242	PHOSPHORYLATION	455030	FFQQQMIyDSPPSRA		molecular association, regulation		CDK6(INDUCES)		11387287	2	7	261	promotes HGF-induced DNA synthesis	
LLGL1	Cell adhesion; Cytoskeletal protein; Motility/polarity/chemotaxis	Q15334	3996	LLGL1	17p11.2	human	S663	PHOSPHORYLATION	449917	LKKSLRQsFRRIRKS		intracellular localization				12660605	2	5	8	localization to cell periiphery and regulation of cell polarization	
hnRNP K	RNA binding protein; RNA splicing; Spliceosome	P61978	3190	HNRNPK	9q21.32-q21.33	human	Y234	PHOSPHORYLATION	456002	PNFYDETyDYGGFTM	Phi-29_GP3		translation, altered			6566	1	1	0	based on Y72/225/230/234/236/380A mutant	
CFTR	Channel, chloride; EC 3.6.3.49; Hydrolase; Membrane protein, integral; Membrane protein, multi-pass; Transporter	P13569	1080	CFTR	7q31.2	human	T582	PHOSPHORYLATION	2907507	FGYLDVLtEKEIFES		activity, induced				8384; 8371	2	0	0		
FHOD1	Actin binding protein	Q9Y613	29109	FHOD1	16q22	human	S1137	PHOSPHORYLATION	2035403	RSRGNRKsLRRTLKS		activity, induced	cytoskeletal reorganization; cell growth, altered	FHOD1(DISRUPTS)		17431547; 1968357	2	0	8	autoinhibitory interaction between C- and N-terminal part of FHOD1 is attenuated in S1130D/S1136D/T1140D triple mutant	
LTB4R	GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR	O88855	16995	Ltb4r		mouse	S127	PHOSPHORYLATION	2862101	AVARPFMsQKVRTKA	7tm_1; DUF1361	receptor desensitization, altered				2856306	1	0	0		
MARCKS	Actin binding protein; Motility/polarity/chemotaxis	P26645	17118	Marcks		mouse	S160	PHOSPHORYLATION	466360	FKKSFKLsGFSFKKS	MARCKS	intracellular localization	carcinogenesis, induced; cell motility, altered			15027801	5	23	5		
CK1E	EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, CK1; Protein kinase, Ser/Thr (non-receptor)	P49674	1454	CSNK1E	22q13.1	human	S323	PHOSPHORYLATION	453416	RMGQLRGsATRALPP		enzymatic activity, inhibited				8419; 2331	2	2	1	some subset of these 8 sites	
EphA4	EC 2.7.1.112; EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Protein kinase, TK; Protein kinase, tyrosine (receptor)	Q03137	13838	Epha4		mouse	Y602	PHOSPHORYLATION	450857	TYVDPFTyEDPNQAV		enzymatic activity, induced	cell motility, altered; cytoskeletal reorganization			6739; 1052900	6	14	156	YY->EE mutation induced receptor clustering that induced growth cone collapse and axonal guidance problems.; in vitro	
Nur77	Apoptosis; DNA binding protein; Nuclear receptor	P22736	3164	NR4A1	12q13	human	S95	PHOSPHORYLATION	471072	TSSSSATsPASASFK		protein degradation; protein stabilization; molecular association, regulation; activity, inhibited	cell cycle regulation; transcription, altered	Pin1(INDUCES)	DNA(DISRUPTS)	9025; 21683712	2	0	0	required for cell proliferation; Phosphorylation inhibits transcription.	
LRRC4C	Cell development/differentiation; Membrane protein, integral	Q9HCJ2	57689	LRRC4C	11p12	human	S631	PHOSPHORYLATION	3893278	PLLIRMNsKDNVQET		molecular association, regulation		PSD-95(INDUCES)		26341721	1	6	4	dendritic spine morphogenesis	
PAX6	DNA binding protein; Motility/polarity/chemotaxis; Transcription factor	P63015	18508	Pax6		mouse	T304	PHOSPHORYLATION	458809	QPIPQPTtPVSSFTS			transcription, induced			7464	1	0	1		
PDE4B	EC 3.1.4.17; Nucleotide Metabolism - purine; Phosphodiesterase	Q07343	5142	PDE4B	1p31	human	S659	PHOSPHORYLATION	471380	YQSMIPQsPSPPLDE		enzymatic activity, inhibited				9133	1	4	0	increases levels of cAMP	
Cx43	Channel, misc.; Membrane protein, integral; Membrane protein, multi-pass; Motility/polarity/chemotaxis	P08050	24392	Gja1		rat	S325	PHOSPHORYLATION	449992	NRMGQAGsTISNSHA		intracellular localization	cell adhesion, altered			2541	7	9	0		
BRCA1	EC 6.3.2.-; Nuclear receptor co-regulator; Transcription, coactivator/corepressor; Tumor suppressor; UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase	P48754	12189	Brca1		mouse	S971	PHOSPHORYLATION	448526	QSVSPIRsSIKTDNR			cell cycle regulation			4543	6	0	0		
NFkB-p105	DNA binding protein; Transcription factor	P19838	4790	NFKB1	4q24	human	S337	PHOSPHORYLATION	449967	FVQLRRKsDLETSEP			transcription, altered			1968305; 2526	3	0	0	required for DNA binding and transactivation	
GMFG	Actin binding protein	O60234	9535	GMFG	19q13.2	human	S2	PHOSPHORYLATION	467229	______MsDSLVVCE	SPOUT_MTase	molecular association, regulation	cytoskeletal reorganization	ARPC3(INDUCES); ACTA1(INDUCES)		8138	1	0	0	phosphorylation of this site enhances binding of GMFG to F-actin and reduces the interaction between F-actin and cofilin	
PSD-95	Adaptor/scaffold	P31016	29495	Dlg4		rat	Y397	PHOSPHORYLATION	473889	AQYKPEEySRFEAKI		protein conformation		CRIPT(DISRUPTS)		21385507	1	2	21	Y397E mutant showed dissociation, and triple mutant Y397E/S415E/S418E, had stronger dissociation. 	
SLBP	RNA binding protein	Q14493	7884	SLBP	4p16.3	human	T62	PHOSPHORYLATION	466352	RRPESFTtPEGPKPR		protein degradation; phosphorylation				8129; 2807217	2	2	9		
HER2	EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Protein kinase, TK; Protein kinase, tyrosine (receptor)	P04626	2064	ERBB2	17q12	human	Y1222	PHOSPHORYLATION	448675	PAFDNLYyWDQDPPE		molecular association, regulation; enzymatic activity, induced	cell motility, altered; transcription, induced; signaling pathway regulation; cell growth, altered	Shc1(INDUCES); MEMO1(INDUCES); Grb2(INDUCES)		10001310; 2852654; 4215300; 22518525; 14821615; 4616	21	1	7		
SLC12A3	Membrane protein, integral; Membrane protein, multi-pass; Transporter	P59158	20497	Slc12a3		mouse	T58	PHOSPHORYLATION	469617	MRTFGYNtIDVVPAY	AA_permease_N	activity, induced				16824200	14	3	0		
IRF1	Transcription factor	P10914	3659	IRF1	5q31.1	human	Y109	PHOSPHORYLATION	2299205	GSSAVRVyRMLPPLT	IRF		transcription, altered			2300800	1	0	0		
NMDAR2A	Channel, ligand-gated; Membrane protein, integral; Membrane protein, multi-pass	Q12879	2903	GRIN2A	16p13.2	human	Y1105	PHOSPHORYLATION	4109553	CSEVERTyLKTKSSS	NMDAR2_C	activity, induced				10274616	2	0	15	potentiation of receptor currents mediated by Src	
MAZ	C2H2-type zinc finger protein; Transcription factor	O97600	100008693	MAZ		rabbit	T386	PHOSPHORYLATION	449095	KDRLRAHtVRHEEKV	FYVE; zf-C2H2_4	activity, induced; protein conformation	transcription, induced		DNA(INDUCES)	2124	1	0	0		
GFAT iso2	Amino Acid Metabolism - alanine, aspartate and glutamate; Carbohydrate Metabolism - amino sugar and nucleotide sugar; EC 2.6.1.16; Transferase	Q06210-2	2673	GFPT1	2p13	human	S243	PHOSPHORYLATION	467935	CNLSRVDsTTCLFPV		enzymatic activity, inhibited				6829227	2	39	492		
CACNA1C	Channel, calcium; Membrane protein, integral; Membrane protein, multi-pass	P15381	100101555	CACB		rabbit	S1928	PHOSPHORYLATION	455278	ASLGRRAsFHLECLK		activity, induced; activity, inhibited				9016; 15785202	21	1	0		
TOP1	EC 5.99.1.2; Isomerase	Q04750	21969	Top1		mouse	Y270	PHOSPHORYLATION	454026	AKMLDHEyTTKEIFR	Topoisom_I_N	enzymatic activity, induced				4172	1	1	1	phosphorylation of this site stimulates the TOP1 isomerase function	
eIF4B	Translation; Translation initiation	Q8BGD9	75705	Eif4b		mouse	S406	PHOSPHORYLATION	470374	RPRERHPsWRSEETQ			translation, altered			6328013	2	20	641		
PAK1	EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, STE; Protein kinase, Ser/Thr (non-receptor)	P35465	29431	Pak1		rat	S21	PHOSPHORYLATION	448174	APPMRNTsTMIGAGS		molecular association, regulation		Nck1(DISRUPTS)		1217	3	0	10		
HSL	EC 3.1.1.79; Lipase	Q05469	3991	LIPE	19q13.2	human	S951	PHOSPHORYLATION	450195	GFHPRRSsQGATQMP	Abhydrolase_3	molecular association, regulation; enzymatic activity, induced		FABP4(INDUCES)		3361004; 6702314	16	7	10		
CD19	Cell surface; Membrane protein, integral	P15391	930	CD19	16p11.2	human	Y439	PHOSPHORYLATION	469560	LSQDGSGyENPEDEP		activity, induced; molecular association, regulation; phosphorylation		PLCG2(INDUCES); VAV1(INDUCES)		8326	1	0	0	ERK2 phosphorylation; Ca(2+) influx	
FGFR3	EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Protein kinase, TK; Protein kinase, tyrosine (receptor)	P22607	2261	FGFR3	4p16.3	human	Y724	PHOSPHORYLATION	448116	ANCTHDLyMIMRECW	Pkinase_Tyr	molecular association, regulation; phosphorylation; enzymatic activity, induced	transcription, altered; cell growth, altered	SH2-B-beta(INDUCES)		2465; 1473	2	1	2	;  stimulates phosphorylation of Shp2, MAPK, Stat1 and Stat3, activates PI3K; stimulates the transforming activity of FGFR3	
SLC4A1	Membrane protein, integral; Membrane protein, multi-pass; Transporter	P02730	6521	SLC4A1	17q21.31	human	Y8	PHOSPHORYLATION	451570	MEELQDDyEDMMEEN		molecular association, regulation		Lyn(INDUCES)		8343	5	12	8	Y8 and/or Y21.	
SLC9A5	Membrane protein, integral; Membrane protein, multi-pass; Transporter	Q14940	6553	SLC9A5	16q22.1	human	S712	PHOSPHORYLATION	20832301	EEEESDSsETEKEDD		molecular association, regulation; activity, inhibited	endocytosis, induced	ARRB1(INDUCES)		20655009	1	0	0	In intact cells ARRB1 ST/AA mutant retained ability to form a complex. 	
XPA	DNA repair	P23025	7507	XPA	9q22.3	human	S196	PHOSPHORYLATION	460698	RSLEVWGsQEALEEA			apoptosis, altered			7756	3	2	0	important for cell survival after UV treatment	
Cdc6	Cell cycle regulation	Q99741	990	CDC6	17q21.3	human	S106	PHOSPHORYLATION	450916	DNQLTIKsPSKRELA		protein stabilization; intracellular localization	cell cycle regulation			7270; 3156	6	1	2		
DAG1	Cytoskeletal protein; Membrane protein, integral; Motility/polarity/chemotaxis	Q62165	13138	Dag1		mouse	Y890	PHOSPHORYLATION	449630	PYRSPPPyVPP____	DAG1	molecular association, regulation; intracellular localization	cytoskeletal reorganization	Tks5(INDUCES)		2262; 5354434	5	1	19	involved in podosome formation	
ELK1	DNA binding protein; Transcription factor	P41969	13712	Elk1		mouse	S390	PHOSPHORYLATION	449757	LSPIAPRsPAKLSFQ		intracellular localization	cell differentiation, altered; transcription, induced; cytoskeletal reorganization; transcription, altered; cell growth, altered		DNA(INDUCES)	4317100; 3427700; 2278	7	0	0		
14-3-3 sigma	Adaptor/scaffold	P31947	2810	SFN	1p36.11	human	S186	PHOSPHORYLATION	456054	FHYEIANsPEEAISL	14-3-3; TPR_12	molecular association, regulation; phosphorylation	apoptosis, induced	Bax(DISRUPTS); JNK1(INDUCES)		7098; 6648	4	0	0		
PTEN	Carbohydrate Metabolism - inositol phosphate; EC 3.1.3.16; EC 3.1.3.48; EC 3.1.3.67; Motility/polarity/chemotaxis; Nuclear receptor co-regulator; PHOSPHATASE; Phosphatase, lipid; Tumor suppressor	P60484	5728	PTEN	10q23.3	human	S229	PHOSPHORYLATION	456213	VKIYSSNsGPTRRED	PTEN_C2		cell motility, altered			6062	1	1	1		
myocardin	Cell development/differentiation; Transcription factor	Q8VIM5	214384	Myocd		mouse	S624	PHOSPHORYLATION	3627505	GQTHVLSsTFLSPQC			transcription, inhibited			6856	1	0	0		
HER2	EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Protein kinase, TK; Protein kinase, tyrosine (receptor)	P06494	24337	Erbb2		rat	Y1114	PHOSPHORYLATION	448674	DLSPLQRySEDPTLP		molecular association, regulation		EGFR(INDUCES)		4723	6	2	1		
Drosha	EC 3.1.26.3; RNA binding protein; RNA processing; Ribonuclease	Q9NRR4	29102	DROSHA	5p13.3	human	S302	PHOSPHORYLATION	14572633	RDNRRSPsLERSYKK		intracellular localization				14780518; 20540215	2	5	0	nuclear localization	
Abl	EC 2.7.1.112; EC 2.7.10.2; KINASE; Kinase, protein; Protein kinase, TK; Protein kinase, tyrosine (non-receptor)	P00520	11350	Abl1		mouse	Y232	PHOSPHORYLATION	450302	IYGVSPNyDKWEMER		activity, induced				5916	2	6	254		
ZBED3	DNA binding protein	Q3TSB2	72114	Zbed3		mouse	S111	PHOSPHORYLATION	6738702	MPCPPPPsPTMAAEG		molecular association, regulation		axin 1(INDUCES)		6701101	1	0	0	 interaction beween ZBED3 and axin is important for ZBED3 to inhibit beta catenin (CTNNB1) phosphorylation by GSK3 beta  ; activates Wnt signaling	
NCAM-L1	Cell adhesion; Membrane protein, integral	P32004	3897	L1CAM	Xq28	human	Y1176	PHOSPHORYLATION	456529	KDETFGEyRSLESDN	Bravo_FIGEY	molecular association, regulation; intracellular localization; phosphorylation		AP2M1(NOT_REPORTED); AP2M1(DISRUPTS)		9985921; 12051; 8605; 12048	10	1	10	mutation of this site promotes phosphorylation of N-CAML1 Y1211	
SSTR3	GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR	P30936	171044	Sstr3		rat	S346	PHOSPHORYLATION	456709	RPSRRVRsQEPGSGP		receptor desensitization, altered; receptor internalization, altered				4062	1	0	1		
Tel	DNA binding protein; Motility/polarity/chemotaxis; Transcription factor	P41212	2120	ETV6	12p13	human	S257	PHOSPHORYLATION	451378	ESHPKPSsPRQESTR		molecular association, regulation; intracellular localization; activity, inhibited	cell differentiation, altered; transcription, induced; transcription, inhibited; cell growth, altered		DNA(DISRUPTS)	2415909; 3580	3	2	0		
PIAS1	EC 6.3.2.-; Nuclear receptor co-regulator; SUMO LIGASE; SUMO conjugating system; Transcription, coactivator/corepressor	O75925	8554	PIAS1	15q	human	S467	PHOSPHORYLATION	4700788	IDLTIDSsSDEEEEE		molecular association, regulation	transcription, inhibited	SUMO2(INDUCES); SUMO1(INDUCES)		6829202	2	5	0		
ELK1	DNA binding protein; Transcription factor	P19419	2002	ELK1	Xp11.2	human	S389	PHOSPHORYLATION	449757	LSPIAPRsPAKLSFQ		activity, induced; protein conformation	transcription, induced; transcription, altered			2270; 6205	7	0	0		
SP1	C2H2-type zinc finger protein; DNA binding protein; Transcription factor	P08047	6667	SP1	12q13.1	human	S101	PHOSPHORYLATION	767911	DLTATQLsQGANGWQ		intracellular localization				3309519	4	0	0		
CADPS	Vesicle protein	Q62717	26989	Cadps		rat	S6	PHOSPHORYLATION	7712500	__MLDPSsSEEESDE		activity, induced	exocytosis, altered			7601405	1	1	0		
JunD	Motility/polarity/chemotaxis; Transcription factor	P15066	16478	Jund		mouse	S90	PHOSPHORYLATION	473544	APDGLLAsPDLGLLK	Jun		transcription, altered			9207	1	3	2		
mGluR7	GPCR, family 3; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR	P35400	81672	Grm7		rat	S862	PHOSPHORYLATION	2846504	NVQKRKRsFKAVVTA		molecular association, regulation; receptor internalization, inhibited	endocytosis, inhibited	calmodulin(DISRUPTS)		8641; 27902354	3	0	0		
Bax	Apoptosis; Membrane protein, integral; Mitochondrial	Q07812	581	BAX	19q13.3-q13.4	human	S163	PHOSPHORYLATION	469571	GGWDGLLsYFGTPTW		activity, induced; intracellular localization	apoptosis, induced			970023; 8296	2	0	0		
Cx43	Channel, misc.; Membrane protein, integral; Membrane protein, multi-pass; Motility/polarity/chemotaxis	P23242	14609	Gja1		mouse	S365	PHOSPHORYLATION	459207	IVDQRPSsRASSRAS		intracellular localization; protein conformation				12232	9	10	2	S363, S364 phosphorylation prevent an antibody to the Cx43 C-terminus.  	
ERK2	EC 2.7.11.24; KINASE; Kinase, protein; Protein kinase, CMGC; Protein kinase, Ser/Thr (non-receptor)	P63086	116590	Mapk1		rat	S27	PHOSPHORYLATION	7989100	GPRYTNLsYIGEGAY	Pkinase	molecular association, regulation; enzymatic activity, induced		MEK2(INDUCES); MEK1(INDUCES)		7910507	1	0	0		
ephexin-1	Guanine nucleotide exchange factor, Rac/Rho	Q923H2	53972	Ngef		mouse	Y177	PHOSPHORYLATION	455579	IEQIGLLyQEYRDKS		activity, induced	cell motility, altered; cytoskeletal reorganization			5518	4	0	2		
PTRF	Transcription initiation complex	O54724	19285	Ptrf		mouse	S368	PHOSPHORYLATION	452129	TDLLRGSsPDVHTLL		phosphorylation				18119112	2	15	28	 regulates phosphorylation of HSL S557 (aka S563) and S651 (aka S660); regulates lipolysis in adipocytes	
TGFBR2	EC 2.7.11.30; KINASE; Kinase, protein; Membrane protein, integral; Protein kinase, Ser/Thr (receptor); Protein kinase, TKL	Q62312	21813	Tgfbr2		mouse	Y309	PHOSPHORYLATION	479864	KIFPYEEySSWKTEK	Pkinase		cytoskeletal reorganization; cell growth, altered			2195723	2	0	0	important for TGF beta -induced cell invasion	
Met	EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Protein kinase, TK; Protein kinase, tyrosine (receptor)	P08581	4233	MET	7q31	human	Y1349	PHOSPHORYLATION	448472	STFIGEHyVHVNATY		molecular association, regulation; enzymatic activity, inhibited; activity, inhibited	cell motility, altered; cell growth, altered	Src(INDUCES); PLCG1(INDUCES); Gab1(INDUCES); Shc1(INDUCES); Met(INDUCES); FAK(INDUCES); Grb2(INDUCES); PIK3R1(INDUCES)		2466202; 713; 2852648; 2845; 2843; 10351400; 5482; 2842; 2846; 2847	21	5	89		
Myb	DNA binding protein; Transcription factor	P10242	4602	MYB	6q22-q23	human	S12	PHOSPHORYLATION	448187	PRHSIYSsDEDDEDF		molecular association, regulation	transcription, altered		DNA(DISRUPTS)	2173	5	1	2		
SRC-1	ACETYLTRANSFERASE; Acetyltransferase; DNA binding protein; EC 2.3.1.48; Nuclear receptor co-regulator; Transcription, coactivator/corepressor	Q15788	8648	NCOA1	2p23	human	T1179	PHOSPHORYLATION	449063	NYGTNPGtPPASTSP	DUF1518		transcription, altered			5309423; 2104	4	0	0	activates cPR A form receptor	
KIF2C	Cancer Testis Antigen (CTA); Microtubule binding protein; Motility/polarity/chemotaxis; Motor protein	Q99661	11004	KIF2C	1p34.1	human	T537	PHOSPHORYLATION	14157500	LGQNKAHtPFRESKL	Kinesin; UvrD_C	intracellular localization; activity, inhibited	cell cycle regulation; cytoskeletal reorganization			14058622	1	0	0		
FCP1	EC 3.1.3.16; Motility/polarity/chemotaxis; PHOSPHATASE; Protein phosphatase, Ser/Thr (non-receptor); Transcription initiation complex	Q9Y5B0	9150	CTDP1	18q23	human	S942	PHOSPHORYLATION	455466	SSNEDEGsSSEADEM	FCP1_C	molecular association, regulation	transcription, altered	GTF2F1(INDUCES)		6829233; 5226	2	0	1		
Smad4	DNA binding protein; Transcription, coactivator/corepressor	Q13485	4089	SMAD4	18q21.1	human	T77	PHOSPHORYLATION	17478300	KCVTIQRtLDGRLQV	MH1	molecular association, regulation	transcription, altered		DNA(DISRUPTS)	17431512	1	0	0	negatively regulates TGFbeta signaling	
RhoGDI alpha	Apoptosis; Cell adhesion; Cell development/differentiation; G protein regulator, misc.; Motility/polarity/chemotaxis	P52565	396	ARHGDIA	17q25.3	human	K141	ACETYLATION	461817	RKGVKIDkTDYMVGS	Rho_GDI		cytoskeletal reorganization			8130	0	2	3		
Rin1	Guanine nucleotide exchange factor, Rab	Q921Q7	225870	Rin1		mouse	Y120	PHOSPHORYLATION	2796501	PSFVSSHyIEESTGG	SH2	molecular association, regulation		Arg(INDUCES)		6201	1	0	0		
APP iso4	Apoptosis; Cell surface; Membrane protein, integral; Receptor, misc.; Transcription factor	P05067-4	351	APP	21q21.3	human	S206	PHOSPHORYLATION	450332	ADAEEDDsDVWWGGA	SDA1	intracellular localization				3094	1	1	0	APP was phosphorylated within the post Golgi as well as on the cell surface. 	
Kv7.1	Channel, potassium; Membrane protein, integral; Membrane protein, multi-pass	P51787	3784	KCNQ1	11p15.5	human	S409	PHOSPHORYLATION	456162	SHTLLSPsPKPKKSV		activity, induced				6659	1	3	0		
KCNE3	Channel, potassium	Q9Y6H6	10008	KCNE3	11q13.4	human	S82	PHOSPHORYLATION	460569	LILGYTRsRKVDKRS	ISK_Channel	activity, induced				7673	2	0	0	controls KCNE3-Kv3.4 channel opening	
NFAT3	DNA binding protein; Transcription factor	Q14934	4776	NFATC4	14q11.2	human	S217	PHOSPHORYLATION	953803	GLGSPLPsPRASPRP			transcription, induced			762729	1	3	1		
ACC1	Carbohydrate Metabolism - propanoate; Carbohydrate Metabolism - pyruvate; EC 6.3.4.14; EC 6.4.1.2; Ligase; Lipid Metabolism - fatty acid biosynthesis	P11497	60581	Acaca		rat	S77	PHOSPHORYLATION	448291	LAFHMRSsMSGLHLV		enzymatic activity, inhibited				2742	6	2	0		
Ikaros	C2H2-type zinc finger protein; DNA binding protein; Transcription factor	Q13422	10320	IKZF1	7p13-p11.1	human	S361	PHOSPHORYLATION	14160239	LAEGTPRsNHSAQDS		molecular association, regulation; intracellular localization	cell differentiation, induced; transcription, induced		DNA(INDUCES)	27132479	1	2	0	 induces transcription of DNAJC6, EIF4e3, TNFAIP8L2; nuclear localization	
GIRK1	Channel, potassium; Membrane protein, integral; Membrane protein, multi-pass	NP_113798	50599	Kcnj3		rat	Y67	PHOSPHORYLATION	3146602	LGSETSRyLSDLFTT	IRK	activity, inhibited				8596	1	1	0		
SHIP	EC 3.1.3.86; EC 3.1.3.n1; Motility/polarity/chemotaxis; Phosphatase, lipid	Q9ES52	16331	Inpp5d		mouse	Y918	PHOSPHORYLATION	450030	NEMINPNyIGMGPFG		molecular association, regulation		Shc1(INDUCES); Dok1(INDUCES)		2580; 2583	2	5	174		
IHPK2	EC 2.7.4.21; Kinase, other; Motility/polarity/chemotaxis	Q9UHH9	51447	IP6K2	3p21.31	human	S359	PHOSPHORYLATION	478423	LEDLSEEsADESAGA	IPK		apoptosis, induced; cell growth, altered	TRAF2(INDUCES)	DNA(INDUCES)	9585	1	0	0	induces NFkB-DNA binding	
AML1 iso8	DNA binding protein; Transcription factor	Q01196-8	861	RUNX1	21q22.3	human	S276	PHOSPHORYLATION	454399	DTRQIQPsPPWSYDQ		protein degradation; phosphorylation				9029; 6620	9	5	44	Mutatuion of S276A and S303A prevents nocodozole-induced phosphorylation of S293 and T300.; Phosphorylation promotes degradation via Cdc20-mediated pathways (Cdh1-mediated regardless of phosphorylation state).	
VAMP2	Membrane protein, integral; Motility/polarity/chemotaxis; Vesicle protein	P63044	22318	Vamp2		mouse	T35	PHOSPHORYLATION	12473004	SNRRLQQtQAQVDEV	Med17; Tweety; CD34_antigen; Synaptobrevin; DUF912	molecular association, regulation		ATM(INDUCES)		12343101	1	0	0	complex of ATM, VAMP2, ATR and SYN1	
HSPA9B	Chaperone	P38646	3313	HSPA9	5q31.1	human	T62	PHOSPHORYLATION	483967	VVGIDLGtTNSCVAV	HSP70	protein stabilization				12005	1	0	0	 ; phosphorylation of this site stabilizes HSPA9B, activates TTK and promotes centrosome re-duplication	
rabphilin 3A	Vesicle protein	P47709	171039	Rph3a		rat	S234	PHOSPHORYLATION	455904	GPPTRRAsEARMSTT		intracellular localization		14-3-3 beta(INDUCES)		6424; 26341751	4	0	2	hormone secretion	
DAB1	Adaptor/scaffold	P97318	13131	Dab1		mouse	Y232	PHOSPHORYLATION	447961	SQKKEGVyDVPKSQP		molecular association, regulation; intracellular localization	cell motility, altered; cytoskeletal reorganization; cell adhesion, altered	Nck2(INDUCES); CrkL(INDUCES)		6498; 10425111; 3654; 3631	12	4	12		
PAM	EC 1.14.17.3; EC 4.3.2.5; Lyase; Membrane protein, integral; Oxidoreductase; Vesicle protein	P14925	25508	Pam		rat	T946	PHOSPHORYLATION	455820	KGFDRVStEGSDQEK		intracellular localization; enzymatic activity, induced				14081217; 6322	2	2	0		
CASK	Adaptor/scaffold; EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, CAMK; Protein kinase, Ser/Thr (non-receptor)	O70589	12361	Cask		mouse	S51	PHOSPHORYLATION	1261103	DVAKFTSsPGLSTED	Pkinase	molecular association, regulation; intracellular localization		liprin alpha 1(DISRUPTS)		1172872	1	1	0	promotes CASK recruitment to presynaptic membranes and interaction with presynaptic proteins (Veli, Mint1, neurexins, N-type voltage-gated calcium channels);  ;   promotes calcium influx into neurons;  promotes synaptogenesis	
Met	EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Protein kinase, TK; Protein kinase, tyrosine (receptor)	P16056	17295	Met		mouse	Y1233	PHOSPHORYLATION	448471	DMYDKEYySVHNKTG	Pkinase_Tyr	ubiquitination; enzymatic activity, induced				4961500; 9721216; 2849	35	11	407		
Ago2	EC 3.1.26.n2; RNA processing	Q9UKV8	27161	EIF2C2	8q24	human	Y529	PHOSPHORYLATION	17533104	LPGKTPVyAEVKRVG	Piwi	molecular association, regulation; intracellular localization; activity, inhibited		Dicer1(DISRUPTS)	RNA(DISRUPTS)	17431522	1	1	0		
AML1 iso8	DNA binding protein; Transcription factor	Q01196-8	861	RUNX1	21q22.3	human	S48	PHOSPHORYLATION	452744	TPPSTALsPGKMSEA		molecular association, regulation	cell growth, altered	HDAC1(DISRUPTS); HDAC3(DISRUPTS)		17431513	2	13	11	increases marrow progenitor proliferation	
KCNN4	Channel, potassium; Membrane protein, integral; Membrane protein, multi-pass	Q9QYW1	65206	Kcnn4		rat	T327	PHOSPHORYLATION	452144	AWMYYKHtRRKDSRA	CaMBD	activity, inhibited				4074	2	0	0		
MeCP2	Transcription, coactivator/corepressor	P51608	4204	MECP2	Xq28	human	S80	PHOSPHORYLATION	452713	AVPEASAsPKQRRSI			apoptosis, altered			11189909	4	39	1		
p90RSK	EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor); Translation	Q63531	81771	Rps6ka1		rat	S380	PHOSPHORYLATION	447990	HQLFRGFsFVATGLM	Pkinase_C	activity, induced; enzymatic activity, induced				849; 10144225	45	26	62	!4-3-3  binding inhibits S363 andd S380 phosphorylation and enzyme activity.	
DMBT1	Membrane protein, integral; Secreted; Secreted, signal peptide	Q60997	12945	Dmbt1		mouse	T2073	PHOSPHORYLATION	13201902	AFTLGRRtHIDRGQP		molecular association, regulation	exocytosis, altered; cytoskeletal reorganization	NHERF(INDUCES); ACTB(INDUCES)		12668816	1	0	0	Phosphomimetic peptides associate with the cytoskeleton, though not binding directly to actin.	
ABCC9	Channel, potassium; Membrane protein, integral; Membrane protein, multi-pass; Transporter	P70170	20928	Abcc9		mouse	S1351	PHOSPHORYLATION	483972	RTGSGKSsLSLAFFR	ABC_tran	activity, induced				11977	1	0	0		
CCAR1	Apoptosis; RNA splicing	Q8IX12	55749	CCAR1	10q21.3	human	Y192	PHOSPHORYLATION	460702	RVLVEATyNPNMPFK	S1-like		apoptosis, induced			7748	1	1	0		
TBX21	DNA binding protein; Transcription factor	Q9JKD8	57765	Tbx21		mouse	S508	PHOSPHORYLATION	458229	PSSGDSSsPAGAPSP		molecular association, regulation		NFkB-p65(INDUCES)		7283	1	1	0	DNA binding activity of NFkB-p65 is reduced in the presence of T-bet 	
gp130	Membrane protein, integral; Receptor, cytokine	P40189	3572	IL6ST	5q11.2	human	Y814	PHOSPHORYLATION	450054	GILPRQQyFKQNCSQ			cell cycle regulation; transcription, altered			1364	2	0	1		
14-3-3 epsilon	Adaptor/scaffold	P62258	7531	YWHAE	17p13.3	human	K118	ACETYLATION	474724	AANTGESkVFYYKMK	14-3-3	molecular association, regulation		SF2(DISRUPTS); TSC22D1(DISRUPTS); SFRS6(DISRUPTS); PLEKHQ1(DISRUPTS); Gab2(DISRUPTS); RAF1(DISRUPTS); Dok3(DISRUPTS); SFRS4(DISRUPTS); VASP(DISRUPTS); HDAC4(DISRUPTS); TSC2(DISRUPTS); SFRS10(DISRUPTS); LARP(DISRUPTS); ARAF(DISRUPTS); GBF1(DISRUPTS); SRm300(DISRUPTS)		8156721	0	1	2		
PLCL1	Phospholipase	Q3USB7	227120	Plcl1		mouse	T94	PHOSPHORYLATION	453436	KCGGRKKtVSFSSMP		molecular association, regulation		PPP1CA(DISRUPTS)		4148	1	4	5		
FOXO1A	DNA binding protein; Nuclear receptor co-regulator; Transcription factor	Q12778	2308	FOXO1	13q14.1	human	K274	ACETYLATION	15625102	RSRAAKKkASLQSGQ		intracellular localization; phosphorylation				15022750	1	0	0		
Kv3.4	Channel, potassium; Membrane protein, integral; Membrane protein, multi-pass	Q03721	3749	KCNC4	1p21	human	S9	PHOSPHORYLATION	451076	ISSVCVSsYRGRKSG	Potassium_chann	receptor inactivation, altered				3296	1	0	0		
PINK1	EC 2.7.11.1; KINASE; Kinase, protein; Membrane protein, integral; Mitochondrial; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor)	Q9BXM7	65018	PINK1	1p36	human	S402	PHOSPHORYLATION	25792201	GLQLPFSsWYVDRGG	Pkinase	intracellular localization				25712624	3	1	0	promotes mitochondrial localization of parkin	
PPAR-gamma	DNA binding protein; Nuclear receptor	P37238	19016	Pparg		mouse	K293	ACETYLATION	25780501	GEDKIKFkHITPLQE		molecular association, regulation		N-CoR1(INDUCES); PRDM1(INDUCES)		25712640	1	1	0		
TTP	DNA binding protein; RNA binding protein	P22893	22695	Zfp36		mouse	S178	PHOSPHORYLATION	451151	HVLRQSIsFSGLPSG		molecular association, regulation; protein stabilization; intracellular localization; activity, inhibited	translation, altered	14-3-3 beta(INDUCES); CAF-1A(DISRUPTS); CAF-1B(DISRUPTS)		15022710; 7769; 8864	5	7	7		
HDAC2	DEACETYLASE; Deacetylase; EC 3.5.1.98; Nuclear receptor co-regulator; Transcription, coactivator/corepressor	P70288	15182	Hdac2		mouse	S422	PHOSPHORYLATION	467979	IACDEEFsDSEDEGE		enzymatic activity, induced				20507101	2	37	35		
IRS1	Adaptor/scaffold; Motility/polarity/chemotaxis	P35568	3667	IRS1	2q36	human	S1223	PHOSPHORYLATION	456047	SSSTRRSsEDLSAYA		activity, inhibited		SHP-2(DISRUPTS)		6599	3	12	0		
GSTA4	EC 2.5.1.18; Other Amino Acids Metabolism - glutathione; Transferase; Xenobiotic Metabolism - drug metabolism - cytochrome P450; Xenobiotic Metabolism - metabolism by cytochrome P450	O15217	2941	GSTA4	6p12.1	human	S189	PHOSPHORYLATION	455666	QEYTVKLsNIPTIKR	GST_C	molecular association, regulation; intracellular localization		HSP70(INDUCES)		5706	1	0	0		
InsR	EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Protein kinase, TK; Protein kinase, tyrosine (receptor)	P06213	3643	INSR	19p13.3-p13.2	human	S1332	PHOSPHORYLATION	451590	ENVPLDRsSHCQREE		enzymatic activity, inhibited				3719	2	0	0		
P38A	EC 2.7.1.37; EC 2.7.11.24; KINASE; Kinase, protein; Protein kinase, CMGC; Protein kinase, Ser/Thr (non-receptor)	P47811	26416	Mapk14		mouse	T180	PHOSPHORYLATION	447970	RHTDDEMtGYVATRW	Pkinase	molecular association, regulation; enzymatic activity, induced	transcription, altered	PKCZ(INDUCES)		4324810; 6947; 7857; 7313808; 5121506; 5430; 4862602	305	34	1501		
DBF4	Cell cycle regulation; Protein kinase, regulatory subunit	Q9UBU7	10926	DBF4	7q21.3	human	S502	PHOSPHORYLATION	23010417	FSTDNSGsQPKQKSD			cell cycle regulation			22965803	1	0	0	DBF4 phosphorylaion is important for supressing DNA replication.	
BDP1	EC 3.1.3.48; Motility/polarity/chemotaxis; Protein phosphatase, tyrosine (non-receptor)	Q99952	26469	PTPN18	2q21.1	human	Y389	PHOSPHORYLATION	449000	SAEEAPLySKVTPRA		molecular association, regulation		TEC(INDUCES); SH2D1B(NOT_REPORTED); Arg(NOT_REPORTED)		2955; 27932900	1	18	666		
FRA1	DNA binding protein; Transcription factor	P15407	8061	FOSL1	11q13	human	T217	PHOSPHORYLATION	1270902	LEPEALHtPTLMTTP		protein stabilization				9581	1	0	0		
Src	EC 2.7.10.2; KINASE; Kinase, protein; Protein kinase, TK; Protein kinase, tyrosine (non-receptor)	P00523	396442	SRC		chicken	S17	PHOSPHORYLATION	448231	DPSQRRRsLEPPDST		phosphorylation	cell growth, altered			2307; 1277	9	21	11		
AQP1	Membrane protein, integral; Membrane protein, multi-pass; Transporter	P29972	358	AQP1	7p14	human	T157	PHOSPHORYLATION	482806	VLCVLATtDRRRRDL	MIP; DUF805	activity, induced				11752	2	0	0	phosphorylation by PKC increases ion currents and water permability of AQP1.	
NPM-ALK	Kinase, protein; Protein kinase, TK; Protein kinase, tyrosine (receptor)	AAA58698		NPM/ALK		human	Y664	PHOSPHORYLATION	27275123	TAPGAGHyEDTILKS			transcription, induced			2852671	2	2	0		
myocardin	Cell development/differentiation; Transcription factor	Q8VIM5	214384	Myocd		mouse	S628	PHOSPHORYLATION	3627510	VLSSTFLsPQCSPQH			transcription, inhibited			6856	1	0	0		
Chk2	EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, CAMK; Protein kinase, Ser/Thr (non-receptor)	O96017	11200	CHEK2	22q12.1	human	S28	PHOSPHORYLATION	447548	PHGSVTQsQGSSSQS	DUF966	phosphorylation; enzymatic activity, induced				1026	3	0	0		
GYS1	Carbohydrate Metabolism - starch and sucrose; EC 2.4.1.11; Transferase	P13807	2997	GYS1	19q13.3	human	S641	PHOSPHORYLATION	448237	YRYPRPAsVPPSPSL	Glycogen_syn	enzymatic activity, inhibited				7543506	26	12	2		
PTRF	Transcription initiation complex	O54724	19285	Ptrf		mouse	S42	PHOSPHORYLATION	452127	EEPSGTGsDELIKSD	ADIP	phosphorylation				18119112	1	16	1	 regulates phosphorylation of HSL S557 (aka S563) and S651 (aka S660); regulates lipolysis in adipocytes	
DLX5	DNA binding protein; Transcription factor	P70396	13395	Dlx5		mouse	S217	PHOSPHORYLATION	1725301	SDPMACNsPQSPAVW			transcription, induced			1713113	1	0	0	measured by Osx mRNA levels	
NMDAR2B	Channel, calcium; Channel, ligand-gated; Membrane protein, integral; Membrane protein, multi-pass	Q01097	14812	Grin2b		mouse	Y1472	PHOSPHORYLATION	448167	GSSNGHVyEKLSSIE	NMDAR2_C	activity, induced; intracellular localization; phosphorylation				14654315; 6942; 2415706	20	0	102		
PIK3R1	Enzyme, regulatory subunit; KINASE; Kinase, lipid; Motility/polarity/chemotaxis	P23727	282307	PIK3R1		cow	S608	PHOSPHORYLATION	448133	ENTEDQYsLVEDDED	DUF1338	enzymatic activity, inhibited				1232	2	1	23	phosphorylation causes a decrease in PI3K activity.	
ARAF	EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, Ser/Thr (non-receptor); Protein kinase, TKL	P10398	369	ARAF	Xp11.4-p11.2	human	T452	PHOSPHORYLATION	3306308	IGDFGLAtVKTRWSG	Pkinase_Tyr	enzymatic activity, induced				3301229	0	1	0		
TAB2	Adaptor/scaffold	Q9NYJ8	23118	TAB2	6q25.1	human	S419	PHOSPHORYLATION	456006	NSGASAAsRNMSGQV		intracellular localization				6569	1	0	0		
APP	Apoptosis; Cell surface; Membrane protein, integral; Receptor, misc.; Transcription factor	P05067	351	APP	21q21.3	human	Y757	PHOSPHORYLATION	448202	SKMQQNGyENPTYKF	APP_amyloid	molecular association, regulation		Lyn(INDUCES); Src(INDUCES); Crk(INDUCES); Abl(INDUCES); PLCG1(INDUCES); GRB7(INDUCES); Shc2(INDUCES); Shc3(INDUCES); Nck1(INDUCES); Shc1(INDUCES); DAB1(INDUCES); PLCG2(INDUCES); Grb2(INDUCES); Pin1(INDUCES)		9938511	9	8	836		
NUP210	Membrane protein, integral; Nucleoporin	P11654	58958	Pom210		rat	S1880	PHOSPHORYLATION	482838	SPPSGLWsPAYASH_		molecular association, regulation; intracellular localization				11775	2	6	1	regulation of binding and recruitment of NUP210 to nuclear pore complex;  Mitotic phosphorylation dissociates NUP210 from the NPC.	
IL21R	Membrane protein, integral; Receptor, cytokine	Q9JHX3	60504	Il21r		mouse	Y319	PHOSPHORYLATION	1270906	SALHLSLyPAKEKKF			cell growth, altered			9299	1	0	0		
myomesin 2	Contractile protein; Cytoskeletal protein	P54296	9172	MYOM2	8p23.3	human	S76	PHOSPHORYLATION	466426	RVCAKRVsTQEDEEQ		molecular association, regulation	cytoskeletal reorganization	MYH1(INDUCES)		3271	1	3	1	binding of myomesin 2 adjacent to the amino-terminal domain Mp1, to myosin rod (MYH1)	
DOR-1	GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR	P32300	18386	Oprd1		mouse	Y318	PHOSPHORYLATION	452090	SSLNPVLyAFLDENF	7tm_1	activity, induced; receptor internalization, altered				4034	1	0	0		
LAT iso2	Adaptor/scaffold; Membrane protein, integral	O43561-2	27040	LAT	16p11.2	human	Y110	PHOSPHORYLATION	450202	GANSVASyENEEPAC	LAT	molecular association, regulation; phosphorylation	transcription, altered	Grb2(INDUCES)		2891	1	2	1	leads to ERK phosphorylation, NF-AT transcription	
PKCZ	EC 2.7.11.13; KINASE; Kinase, protein; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor)	P09217	25522	Prkcz		rat	S186	PHOSPHORYLATION	3136104	TCRRHMDsVMPSQEP		molecular association, regulation		14-3-3 beta(INDUCES); RAF1(INDUCES)		8741	2	0	0		
CTNNB1	Actin binding protein; Cell adhesion; Motility/polarity/chemotaxis; Nuclear receptor co-regulator; Transcription factor	P35222	1499	CTNNB1	3p21	human	S37	PHOSPHORYLATION	447582	YLDSGIHsGATTTAP		protein degradation; molecular association, regulation; intracellular localization	cytoskeletal reorganization; cell adhesion, altered; transcription, altered; cell growth, altered	CBLL1(INDUCES)		14654301; 12068405; 2610809; 14146308; 1732; 6842201; 6842213; 8971; 8348	53	3	2	 promotes centrosomal cohesion	
Notch 1	Membrane protein, integral; Motility/polarity/chemotaxis; Receptor, misc.; Transcription factor	Q01705	18128	Notch1		mouse	K2068	ACETYLATION	18899509	EGSYETAkVLLDHFA	Ank_2	protein stabilization; ubiquitination				18899000	1	1	0		
STF-1	Nuclear receptor	P33242	26423	Nr5a1		mouse	K194	SUMOYLATION	2798300	AFSNRTIkSEYPEPY		activity, inhibited; phosphorylation	transcription, altered			5354430	8	0	0	inhibits STF-1 S203 phosphorylation and its activation	
ANXA1	Calcium-binding protein; Lipid binding protein	P04083	301	ANXA1	9q21.13	human	Y21	PHOSPHORYLATION	447974	IENEEQEyVQTVKSS		intracellular localization				6641	4	7	166	EGF-stimulated increase in inward vesiculation is abolished in ANXA1 knockout cells, and rescued by WT but not by Y21F mutant ANXA1.	
KCC2	Membrane protein, integral; Membrane protein, multi-pass; Transporter	Q63633	171373	Slc12a5		rat	Y1110	PHOSPHORYLATION	3087801	NRNGDENyMEFLEVL		activity, induced; protein degradation; molecular association, regulation; intracellular localization		KCC2(INDUCES)		14790321; 9980414	3	0	0	decreases the cell surface stability of SLC12A5 (aka KCC2)	
RASSF1 iso2	Tumor suppressor	Q9NS23-2	11186	RASSF1	3p21.3	human	S175	PHOSPHORYLATION	13258707	LKLVRPVsVPSSKKP		molecular association, regulation	apoptosis, inhibited	TRAIL-R1(DISRUPTS); 14-3-3 zeta(INDUCES); 14-3-3 epsilon(INDUCES); TNF-R1(DISRUPTS); MOAP1(DISRUPTS)		13159408	1	0	0		
Fli1	DNA binding protein; Transcription factor	P26323	14247	Fli1		mouse	S10	PHOSPHORYLATION	8046505	GTIKEALsVVSDDQS		molecular association, regulation	transcription, inhibited	AML1(DISRUPTS)		7889923	1	1	0	inhibits megakaryocyte maturation	
S100A11	Calcium-binding protein; Cell cycle regulation; DNA replication	P31949	6282	S100A11	1q21	human	T10	PHOSPHORYLATION	10888705	KISSPTEtERCIESL	S_100	intracellular localization	cell growth, altered	NCL(INDUCES)		10144221	2	1	0	Nuclear translocation is mediated by T10 phosphorylation. Calcium induced growth inhibition is mediated by T10 and S94 phosphorylation.	
MOR-1	GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR	P35372	4988	OPRM1	6q24-q25	human	S268	PHOSPHORYLATION	447782	LKSVRMLsGSKEKDR	7tm_1	receptor desensitization, altered				8656	3	0	1		
VTN	Cell adhesion; Motility/polarity/chemotaxis; Secreted; Secreted, signal peptide	P04004	7448	VTN	17q11	human	S397	PHOSPHORYLATION	452178	NQNSRRPsRATWLSL		molecular association, regulation; protein conformation; phosphorylation		SERPINE1(DISRUPTS)		8889	3	0	0	decreases accessibility of CKII to phosphorylate VTN	
Mpl	Membrane protein, integral; Receptor, cytokine	Q08351	17480	Mpl		mouse	S566	PHOSPHORYLATION	3091406	LEILPKSsESTPLPL		activity, induced; phosphorylation	cell growth, altered			8388	1	0	0	tyrosine phosphorylation of JAK2	
MOR-1	GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR	P42866	18390	Oprm1		mouse	T376	PHOSPHORYLATION	20727901	NTREHPStANTVDRT		receptor internalization, induced	endocytosis, induced			20726800	4	1	0	endocytosis of MOR-1	
mAChR M2	GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR	P08172	1129	CHRM2	7q31-q35	human	S288	PHOSPHORYLATION	459104	ESSNDSTsVSAVASN	7tm_1	receptor internalization, altered				7628	3	0	0	Mutation of S286 T287 S288 S290 to A caused a faster rate and a greater extent of receptor internalization after agonist stimulation (transients only, not observed in stables).  Mutation of all 8 sites prevented internalization (in both transients and stables).	
CDK2	EC 2.7.11.22; KINASE; Kinase, protein; Protein kinase, CMGC; Protein kinase, Ser/Thr (non-receptor)	P24941	1017	CDK2	12q13	human	T14	PHOSPHORYLATION	447738	VEKIGEGtYGVVYKA	Pkinase	protein stabilization; enzymatic activity, inhibited; protein conformation	cell cycle regulation			633; 30281304; 7102; 5488	9	56	1405	required for recovery from replication stress;  loss of inhibitory phosphorylation causes DNA damage	
CD200R	Membrane protein, integral; Receptor, misc.	Q9ES57	57781	Cd200r1		mouse	Y297	PHOSPHORYLATION	458379	TEKSNPLyDTVTKVE		molecular association, regulation		Dok2(INDUCES); Dok1(INDUCES)		7402	2	0	13		
FAK	EC 2.7.1.112; EC 2.7.10.2; KINASE; Kinase, protein; Protein kinase, TK; Protein kinase, tyrosine (non-receptor)	Q00944	396416	PTK2		chicken	S726	PHOSPHORYLATION	1320900	GYPSPRSsEGFYPSP		phosphorylation				6344	1	0	1	primes for the GSK3-beta phosphorylation of S722	
TSAd	Adaptor/scaffold	Q9NP31	9047	SH2D2A	1q21	human	Y280	PHOSPHORYLATION	449440	PKPSNPIyNEPDEPI		molecular association, regulation		Lck(INDUCES)		4042501	1	3	107		
Kit	EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Protein kinase, TK; Protein kinase, tyrosine (receptor)	P05532	16590	Kit		mouse	Y571	PHOSPHORYLATION	448014	EEINGNNyVYIDPTQ	UPF0220	activity, induced; molecular association, regulation	cell motility, altered; cell growth, altered	Shc1(INDUCES); SOCS6(INDUCES); SHP-2(INDUCES); Gab2(INDUCES); LNK(INDUCES)		7226; 2455804; 6011126	11	2	18		
STAT3	DNA binding protein; Motility/polarity/chemotaxis; Nuclear receptor co-regulator; Transcription factor	P52631	25125	Stat3		rat	Y705	PHOSPHORYLATION	448192	DPGSAAPyLKTKFIC		activity, induced; molecular association, regulation; intracellular localization	cell differentiation, altered; apoptosis, altered; transcription, altered	CBP(INDUCES); SRC-1(INDUCES)		5410112; 1968352; 6301; 7119510; 5755; 7910522; 6914	251	36	3028		
CCDC50 iso2	Inhibitor protein	Q8IVM0	152137	CCDC50	3q28	human	Y145	PHOSPHORYLATION	454594	RAYADSYyYEDGGMK	TAF8_C	molecular association, regulation		EGFR(INDUCES)		3218103	1	9	21	inhibits the down-regulation of EGFR	
HCN4	Channel, cation; Membrane protein, integral; Membrane protein, multi-pass	O70507	330953	Hcn4		mouse	S1140	PHOSPHORYLATION	4699517	TLPRKTSsGSLPPPL		activity, induced				15022705	1	1	0	required for PKA to shift the voltage dependence of HCN4	
PKLR iso2	Carbohydrate Metabolism - glycolysis and gluconeogenesis; Carbohydrate Metabolism - pyruvate; EC 2.7.1.40; Kinase, other; Nucleotide Metabolism - purine	P12928-2	24651	Pklr		rat	S12	PHOSPHORYLATION	1218250	AGYLRRAsVAQLTQE		molecular association, regulation; enzymatic activity, inhibited		PKLR iso2(DISRUPTS)		7549205; 27132424	3	0	6	Mutations at position 9 and 10 changed affected enzyme activity and decreased binding of the substrate phoenolpyruvate, but not another substrate ADP.  	
PREX1	Guanine nucleotide exchange factor, Rac/Rho	Q8TCU6	57580	PREX1	20q13.13	human	S313	PHOSPHORYLATION	18704701	RVTGSKKsTKRTKSI	PH	activity, inhibited				18668001	1	0	0		
perilipin	Lipid binding protein	Q8CGN5	103968	Plin1		mouse	S492	PHOSPHORYLATION	459628	EKPARRVsDSFFRPS		activity, induced; molecular association, regulation; intracellular localization		ABHD5(DISRUPTS)		7483309; 11189917; 9106; 7666	6	4	0	when S517 is phosphorylated, S492 phosphorylation enhances PKA-stimulated lipolysis in adipocytes; phosphorylation of site facilitates lipolysis of lipid droplets.; induces dissociation of ABHD5 from perilipin and its association with Atgl; hosphorylation of S492 induces scattering of lipid droplets throughout the cytoplasm. 	
GIRK1	Channel, potassium; Membrane protein, integral; Membrane protein, multi-pass	NP_113798	50599	Kcnj3		rat	S385	PHOSPHORYLATION	4706226	NSKERHNsVECLDGL	IRK	activity, induced				10425119	3	4	1		
AQP0	Channel, misc.; Membrane protein, integral; Membrane protein, multi-pass	P30301	4284	MIP	12q13	human	S235	PHOSPHORYLATION	450116	KSISERLsVLKGAKP		molecular association, regulation		calmodulin(DISRUPTS)		1713134	4	8	0		
Mnk1	EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, CAMK; Protein kinase, Ser/Thr (non-receptor); Translation	O08605	17346	Mknk1		mouse	S203	PHOSPHORYLATION	11507613	SGVKLNNsCTPITTP	Pkinase	enzymatic activity, induced				10296912	1	0	0		
InsR	EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Protein kinase, TK; Protein kinase, tyrosine (receptor)	P06213	3643	INSR	19p13.3-p13.2	human	S1216	PHOSPHORYLATION	3103704	KDGVFTTsSDMWSFG	Pkinase_Tyr	enzymatic activity, induced				8572	1	0	0		
GPM6A	Cell surface; Channel, calcium; Membrane protein, integral; Membrane protein, multi-pass	Q812E9	306439	Gpm6a		rat	S267	PHOSPHORYLATION	456834	QELHDIHsTRSKERL	DUF2244	activity, induced				11484425	1	5	1		
JunD	Motility/polarity/chemotaxis; Transcription factor	P15066	16478	Jund		mouse	S100	PHOSPHORYLATION	456168	LGLLKLAsPELERLI	Jun		transcription, altered			9207	5	31	12		
TRPV4	Channel, cation; Membrane protein, integral; Membrane protein, multi-pass	Q9EPK8	63873	Trpv4		mouse	Y253	PHOSPHORYLATION	448752	IERRCKHyVELLVAQ	Ank_2	activity, induced				1918	1	0	0		
CFTR	Channel, chloride; EC 3.6.3.49; Hydrolase; Membrane protein, integral; Membrane protein, multi-pass; Transporter	P26361	12638	Cftr		mouse	S659	PHOSPHORYLATION	11929100	QFTEERRsSILTETL	CFTR_R	protein conformation				11424200	0	1	0	in vitro	
Akt1	EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor)	P31749	207	AKT1	14q32.32	human	S473	PHOSPHORYLATION	447855	RPHFPQFsYSASGTA	Pkinase_C	activity, induced; protein degradation; molecular association, regulation; intracellular localization; phosphorylation; enzymatic activity, induced	cell cycle regulation; carcinogenesis, induced; apoptosis, altered; carcinogenesis, altered; cell motility, induced; transcription, altered; cell differentiation, altered; apoptosis, inhibited; cell motility, altered; cytoskeletal reorganization; cell growth, altered	PPP2CA(INDUCES); rictor(INDUCES); ILK(INDUCES); PDK1(INDUCES); PIK3R1(INDUCES); PAK1(INDUCES)		2708103; 5282; 4534; 30280005; 4861514; 9689403; 5323; 4646606; 6702302; 6235; 6060; 6842230; 4646603; 4484; 6069; 4768; 6511; 1080; 5424; 5519; 1623; 913; 6011113; 6786; 6271026; 6554; 6782007; 12728100; 3394311; 6752; 5285; 8911; 4515; 22767400; 9166; 5279; 1173000; 12558736; 4214828; 6537; 7397604; 12008; 6061; 7228; 13788302; 12662612; 847; 6541; 4214812; 4646607; 12735103; 6575; 5253; 7309805; 4759; 4461; 5764	1158	5	43	Mn58B inhibits tumor growth through S473 phosphorylation.;  increase of RhoA and Cdc42 activity, motility, migration, and invasion; higher in brain metastases than liver and lung metastases	
ARAF	EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, Ser/Thr (non-receptor); Protein kinase, TKL	P10398	369	ARAF	Xp11.4-p11.2	human	Y302	PHOSPHORYLATION	455522	GYRDSGYyWEVPPSE		activity, induced				5373	1	5	88		
GBF1	Guanine nucleotide exchange factor, ARF	Q92538	8729	GBF1	10q24	human	T1337	PHOSPHORYLATION	454448	GKIHRSAtDADVVNS		intracellular localization	cell cycle regulation			27619340	2	9	29	 attenuates membrane association; required for mitosis	
ARRB1	Adaptor/scaffold	P49407	408	ARRB1	11q13	human	S412	PHOSPHORYLATION	447493	EEEDGTGsPQLNNR_		activity, induced; molecular association, regulation; activity, inhibited		ADRB2(DISRUPTS); MEKK1(INDUCES)		4642414; 2231; 7124729	7	18	1		
PrlR	Membrane protein, integral; Receptor, cytokine	P16471	5618	PRLR	5p13.2	human	S349	PHOSPHORYLATION	451641	YLDPDTDsGRGSCDS		protein degradation; molecular association, regulation; phosphorylation	cell motility, altered; transcription, altered; cell growth, altered	FBW1B(INDUCES)		3753; 7313817	4	0	0		
ezrin	Cytoskeletal protein; Motility/polarity/chemotaxis	P26040	22350	Ezr		mouse	T235	PHOSPHORYLATION	449293	YEKDDKLtPKIGFPW	FERM_C	activity, induced; intracellular localization	cytoskeletal reorganization			2165	1	0	0	The expression of activated variants of ezrin T234D,T566D) did induce a morphological reminiscent of the senescent phenotype.	
PKCE	EC 2.7.11.13; KINASE; Kinase, protein; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor)	P16054	18754	Prkce		mouse	T710	PHOSPHORYLATION	450184	TREEPILtLVDEAII	Pkinase_C	enzymatic activity, induced				2207	3	10	31		
SIT	Adaptor/scaffold; Membrane protein, integral	Q9Y3P8	27240	SIT1	9p13-p12	human	Y148	PHOSPHORYLATION	451883	GPGTPVKySEVVLDS		molecular association, regulation		SHP-2(INDUCES)		12482229	2	6	249		
CACNA1C	Channel, calcium; Membrane protein, integral; Membrane protein, multi-pass	P15381	100101555	CACB		rabbit	S1829	PHOSPHORYLATION	451189	EGHGSPLsPAVRAQE		activity, induced				3392	1	1	0		
SIPA1L1	GTPase activating protein, Ras	O43166	26037	SIPA1L1	14q24.2	human	S1632	PHOSPHORYLATION	3892364	SLPLRRPsYTLGMKS	DUF3401	molecular association, regulation		PSD-95(INDUCES)		25229706	1	5	62	Fluorescence Polarization	
PLB	Inhibitor protein; Membrane protein, integral	P61012	414755	PLN		dog	S16	PHOSPHORYLATION	448114	RSAIRRAsTIEMPQQ	Phospholamban	molecular association, regulation		SERCA2(DISRUPTS)		3340212	39	8	56		
SynGAP	GTPase activating protein, Ras	Q9QUH6	192117	Syngap1		rat	S1138	PHOSPHORYLATION	451016	PSITKQHsQTPSTLN	DUF3498	activity, induced				3266	1	1	0		
C/EBP-alpha	DNA binding protein; Transcription factor	P53566	12606	Cebpa		mouse	T226	PHOSPHORYLATION	449825	GHPTPPPtPVPSPHA			transcription, induced; transcription, inhibited			9370; 2369	6	0	0		
BRAF	EC 2.7.1.37; EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, Ser/Thr (non-receptor); Protein kinase, TKL	P15056	673	BRAF	7q34	human	S602	PHOSPHORYLATION	447805	FGLATVKsRWSGSHQ	Pkinase_Tyr	molecular association, regulation; protein conformation; enzymatic activity, induced	cell differentiation, altered; transcription, altered; cell growth, altered	BRAF(NOT_REPORTED)		1746; 4264910; 5254; 6588	8	0	0		
KOR-3	GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR	P35370	29256	Oprl1		rat	S335	PHOSPHORYLATION	456133	RKFCCASsLHREMQV		activity, induced; receptor desensitization, altered				6604	1	0	0		
VCP	Chaperone; DNA repair; Endoplasmic reticulum; Hydrolase	P55072	7415	VCP	9p13.3	human	T761	PHOSPHORYLATION	3653838	KYEMFAQtLQQSRGF	DNA_ligase_A_C; Vps4_C	enzymatic activity, induced				7235500	1	2	0		
CACNG2	Channel, calcium; Membrane protein, integral; Membrane protein, multi-pass	O88602	12300	Cacng2		mouse	S243	PHOSPHORYLATION	455318	RSRSSSRsTEPSHSR	Tetraspannin	activity, induced; intracellular localization				22913905; 4485	1	0	0	AMPAR immobilization in synaptic membrane; enhances AMPA receptor responses and is required for long-term potentiation	
AMPKA1	Autophagy; EC 2.7.1.-; EC 2.7.11.1; EC 2.7.11.26; KINASE; Kinase, protein; Protein kinase, CAMK; Protein kinase, Ser/Thr (non-receptor)	Q5EG47	105787	Prkaa1		mouse	T183	PHOSPHORYLATION	448786	SDGEFLRtSCGSPNY	Pkinase	protein degradation; phosphorylation; enzymatic activity, induced	cytoskeletal reorganization; transcription, altered; cell growth, altered	AMPKA1(INDUCES)		3423; 1193006; 6331326; 904; 11757; 5904; 4214810; 5723	154	11	19		
RYR2	Channel, ligand-gated; Membrane protein, integral; Membrane protein, multi-pass	E9Q401	20191	Ryr2		mouse	G1885	PHOSPHORYLATION	2535900	GEEEAKGgKRPKEGL		activity, induced				2425231	1	0	0	nearly abolished Ca2+ release activity in G1885E/G1886S mutant 	
VCP	Chaperone; DNA repair; Endoplasmic reticulum; Hydrolase	P55072	7415	VCP	9p13.3	human	K696	ACETYLATION	7435507	EICQRACkLAIRESI	DNA_ligase_A_C	enzymatic activity, induced				7235500	1	1	0		
NPHP1	Cell adhesion	O15259	4867	NPHP1	2q13	human	Y46	PHOSPHORYLATION	18449508	PNKRQHIyQRCIQLK		molecular association, regulation; intracellular localization		PACS-1(INDUCES)		18410856	1	0	0		
TUBA1C	Cytoskeletal protein; Motility/polarity/chemotaxis	Q9BQE3	84790	TUBA1C	12q13.12	human	S165	PHOSPHORYLATION	8046500	SVDYGKKsKLEFSIY	Tubulin		cell motility, altered; cytoskeletal reorganization			7889910	1	0	1		
NRF2	DNA binding protein; Transcription factor	Q60795	18024	Nfe2l2		mouse	S342	PHOSPHORYLATION	18258503	SGISLNTsPSRASPE		protein degradation; molecular association, regulation		BTRC(INDUCES)		18021029	2	0	0		
MDM4	EC 6.3.2.-; Ligase; UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase	O35618	17248	Mdm4		mouse	S367	PHOSPHORYLATION	457676	PDCRRTIsAPVVRPK		protein degradation; molecular association, regulation	signaling pathway regulation	14-3-3 gamma(INDUCES)		9985933; 25347018	17	3	2	important for p53 activation 	
TrkB	EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Protein kinase, TK; Protein kinase, tyrosine (receptor)	Q63604	25054	Ntrk2		rat	Y706	PHOSPHORYLATION	448812	DVYSTDYyRVGGHTM	Pkinase_Tyr	molecular association, regulation; enzymatic activity, induced	translation, altered; transcription, altered	Shc1(INDUCES); PLCG1(INDUCES)		7398; 3980; 10199100	7	1	30	c-fos protein synthesis induced by BDNF	
MEF2C	DNA binding protein; Transcription factor	Q2MJT0	309957	Mef2a		rat	S192	PHOSPHORYLATION	487504	ATLHRNVsPGAPQRP		activity, induced	apoptosis, inhibited; transcription, induced			12275	1	0	0		
MITF iso9	DNA binding protein; Transcription factor	O75030-9	4286	MITF	3p14.2-p14.1	human	S298	PHOSPHORYLATION	448503	QARAHGLsLIPSTGL	RNA_pol_Rpb4; DUF3371	activity, induced	transcription, altered			1751	3	0	0		
CREB	DNA binding protein; Transcription factor	P16220	1385	CREB1	2q34	human	S114	PHOSPHORYLATION	451809	ESEDSQEsVDSVTDS	pKID	molecular association, regulation; phosphorylation		CBP(INDUCES)		9565	7	0	1	mutation to alanine decreases S121 phosphorylation in cells treated with ionizing radiation	
DDEF1	GTPase activating protein, ARF; Motility/polarity/chemotaxis	Q9QWY8	13196	Asap1		mouse	Y308	PHOSPHORYLATION	450437	PKEVGGLyVASRANS	DUF4404	molecular association, regulation; activity, inhibited		Pyk2(INDUCES)	Other(DISRUPTS)	8222; 2996	2	0	1	leads to less binding to phospholipids (including P(4,5)P2, PI(3,4,5)P3, and PI(3,4)P2) and less GAP activity toward Arf1	
EGFR	EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Protein kinase, TK; Protein kinase, tyrosine (receptor)	P00533	1956	EGFR	7p12	human	T678	PHOSPHORYLATION	448053	RHIVRKRtLRRLLQE		protein degradation; molecular association, regulation; receptor desensitization, altered; intracellular localization; receptor internalization, altered; enzymatic activity, inhibited; receptor recycling, altered	cytoskeletal reorganization	KPNA1(INDUCES); calmodulin(DISRUPTS); PKCA(NOT_REPORTED); G-alpha-s(DISRUPTS)		5326; 8488; 8436; 2730; 3786; 15278818; 3798; 8097	18	0	0		
ARAP3	GTPase activating protein, ARF; GTPase activating protein, Rac/Rho; Motility/polarity/chemotaxis	Q8WWN8	64411	ARAP3	5q31.3	human	Y1408	PHOSPHORYLATION	454958	PVYEEPVyEEVGAFP			carcinogenesis, altered; cell motility, altered; cell adhesion, altered			17431531	3	1	3	suppresses peritoneal dissemination of scirrhous gastric carcinoma cells	
p16-INK4A	Cell cycle regulation	P42771	1029	CDKN2A	9p21	human	S152	PHOSPHORYLATION	448832	IDAAEGPsDIPD___		protein stabilization; molecular association, regulation		CDK4(INDUCES)		18119108	3	0	0		
PRAS40	Apoptosis	Q96B36	84335	AKT1S1	19q13.33	human	S183	PHOSPHORYLATION	482839	PTQQYAKsLPVSVPV	Senescence_reg	molecular association, regulation		raptor(DISRUPTS)		11805	4	30	23		
RBM8A	RNA binding protein; RNA splicing; Spliceosome; Translation	Q9Y5S9	9939	RBM8A	1q21.1	human	S168	PHOSPHORYLATION	456535	GGRRRSRsPDRRRR_		molecular association, regulation	RNA splicing, altered	NCBP1(DISRUPTS); UPF3B(DISRUPTS); THOC4(DISRUPTS); TAP(DISRUPTS); RPL22(DISRUPTS)		6721	1	4	3	Phosphorylation is required for release downstream factors.  Phosphorylation interferes with RBM8A's arginine methylation in vitro (by rat PRMT1) and in vivo.	
Fyn	EC 2.7.10.2; KINASE; Kinase, protein; Protein kinase, TK; Protein kinase, tyrosine (non-receptor)	Q62844	25150	Fyn		rat	Y420	PHOSPHORYLATION	447882	RLIEDNEyTARQGAK	Pkinase_Tyr	enzymatic activity, induced				9689604	19	55	3061		
mucolipin 1	Channel, cation; Membrane protein, integral; Membrane protein, multi-pass	Q9GZU1	57192	MCOLN1	19p13.2	human	S559	PHOSPHORYLATION	1233700	KFRRGSGsACSLLCC		activity, inhibited				1172824	1	3	0		
FcER1B	Membrane protein, integral; Membrane protein, multi-pass; Receptor, misc.	P13386	25316	Ms4a2		rat	Y224	PHOSPHORYLATION	2883703	LYEELHVySPIYSAL	SUR7	molecular association, regulation		Shc1(INDUCES); Syk(INDUCES); SHIP(INDUCES); SHP-1(INDUCES); Grb2(INDUCES)		2875302	0	1	0	SHIP binding is senstive to the presence of Syk.	
Smad3	DNA binding protein; Nuclear receptor co-regulator; Transcription factor	P84022	4088	SMAD3	15q22.33	human	S418	PHOSPHORYLATION	6845003	LTQMGSPsIRCSSVS		intracellular localization				6841100	2	0	0	nuclear translocation	
PLM	Cell surface; Channel, misc.; Membrane protein, integral	O08589	58971	Fxyd1		rat	T89	PHOSPHORYLATION	455220	SSIRRLStRRR____	IncA	activity, induced				7543537	7	2	49		
RARA	DNA binding protein; Nuclear receptor; Transcription factor	P10276	5914	RARA	17q21	human	S369	PHOSPHORYLATION	451381	YVRKRRPsRPHMFPK	Hormone_recep	molecular association, regulation; intracellular localization; protein conformation; activity, inhibited	transcription, inhibited	RXRA(DISRUPTS)		13359102; 27902365	7	0	0		
SH2-B-beta	Adaptor/scaffold	Q62985-2	89817	Sh2b1		rat	S165	PHOSPHORYLATION	21336501	VGRSVRGsVRGILQW		intracellular localization	cell motility, induced			27619352	2	0	0	disrupt localization at the plasma membrane.; macrophage migration	
HePTP	EC 3.1.3.48; Motility/polarity/chemotaxis; PHOSPHATASE; Protein phosphatase, tyrosine (non-receptor)	P35236	5778	PTPN7	1q32.1	human	S93	PHOSPHORYLATION	448310	ALQRQPPsPKQLEEE		molecular association, regulation; protein conformation		ERK2(DISRUPTS); P38A(DISRUPTS)		2587; 6995	2	5	1		
ADCY2	Adenylyl cyclase; EC 4.6.1.1; Lyase; Membrane protein, integral; Membrane protein, multi-pass; Nucleotide Metabolism - purine	P26769	81636	Adcy2		rat	S490	PHOSPHORYLATION	25795203	DGAKMRAsVRMTRYL		activity, induced				25712658	1	0	0	cAMP release	
IRS1	Adaptor/scaffold; Motility/polarity/chemotaxis	P35568	3667	IRS1	2q36	human	S307	PHOSPHORYLATION	450190	TRRSRTEsITATSPA		molecular association, regulation; intracellular localization; phosphorylation		InsR(DISRUPTS)		6806; 4569; 8915	31	3	1	via cell fractionation experiments	
H3	DNA binding protein	P68431	8350	HIST1H3A	6p22.1	human	S11	PHOSPHORYLATION	455676	TKQTARKsTGGKAPR		activity, induced; molecular association, regulation; methylation; intracellular localization	cell cycle regulation; chromatin organization, altered; cytoskeletal reorganization; transcription, induced; transcription, altered; cell growth, altered	HP1 alpha(DISRUPTS)	DNA(INDUCES)	1163005; 5931; 7309826; 1173024; 12735102; 3256108; 4914002; 3394326; 2463204; 3342620; 7991110	167	5	1	required for accurate chromosome segregation during interphase; inhibits K9 methylation	
H3	DNA binding protein	P68433	360198	Hist1h3a		mouse	S11	PHOSPHORYLATION	455676	TKQTARKsTGGKAPR		molecular association, regulation	chromatin organization, altered; transcription, altered; cell growth, altered	14-3-3 zeta(INDUCES); 14-3-3 epsilon(INDUCES)	DNA(INDUCES)	4260501; 7124718; 15031328	167	5	1		
Arg	EC 2.7.10.2; KINASE; Kinase, protein; Protein kinase, TK; Protein kinase, tyrosine (non-receptor)	P42684	27	ABL2	1q25.2	human	Y439	PHOSPHORYLATION	447923	RLMTGDTyTAHAGAK	Pkinase_Tyr	protein degradation				5567	3	24	1680		
Cdc25B	EC 3.1.3.48; Motility/polarity/chemotaxis; Nuclear receptor co-regulator; PHOSPHATASE; Protein phosphatase, dual-specificity	P30305	994	CDC25B	20p13	human	S323	PHOSPHORYLATION	448409	QRLFRSPsMPCSVIR	M-inducer_phosp	molecular association, regulation	cell cycle regulation	14-3-3 beta(INDUCES); 14-3-3 epsilon(INDUCES)		7418; 6576	11	3	23		
TBL1XR1	Nuclear receptor co-regulator; Transcription, coactivator/corepressor	Q9BZK7	79718	TBL1XR1	3q26.32	human	S123	PHOSPHORYLATION	2509601	AAASQQGsAKNGENT		protein degradation	transcription, induced			2425230	1	0	0		
TRPC6	Channel, cation; Membrane protein, integral; Membrane protein, multi-pass	Q61143	22068	Trpc6		mouse	S448	PHOSPHORYLATION	15794302	KFVAHAAsFTIFLGL	TM	activity, inhibited				15755115	1	0	0		
PTPRH	EC 3.1.3.48; Membrane protein, integral; Motility/polarity/chemotaxis	NP_997153	545902	Ptprh		mouse	Y945	PHOSPHORYLATION	14312603	LVPEEAMyENVASLV		molecular association, regulation	cytoskeletal reorganization	Fyn(INDUCES); Grb2(INDUCES)		14081207	1	0	0		
TNNI3	Actin binding protein; Motility/polarity/chemotaxis; Motor protein	P19429	7137	TNNI3	19q13.4	human	S166	PHOSPHORYLATION	3146609	LGARAKEsLDLRAHL	Troponin	molecular association, regulation		TNNC1(DISRUPTS)		8869	1	3	0		
MOR-1	GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR	P33535	25601	Oprm1		rat	Y166	PHOSPHORYLATION	455805	CTMSVDRyIAVCHPV	7tm_1	activity, inhibited				6183; 12021307	3	0	0	reduces G-protein coupling efficiency of the mu opioid receptor	
KCNQ4	Membrane protein, integral; Membrane protein, multi-pass	P56696	9132	KCNQ4	1p34	human	T552	PHOSPHORYLATION	13301700	AKRKFKEtLRPYDVK	KCNQ_channel	activity, inhibited				13164204	1	0	0	mediates AKAP79 sensitization to inhibition by muscarinic receptor stimulation	
PKCE	EC 2.7.11.13; KINASE; Kinase, protein; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor)	P16054	18754	Prkce		mouse	S346	PHOSPHORYLATION	2807904	SEDDRSKsAPTSPCD	DUF1631		cell cycle regulation			3301203	2	6	0		
MDC1	Cell cycle regulation	Q14676	9656	MDC1	6p21.3	human	T455	PHOSPHORYLATION	453677	TTERDSDtDVEEEEL		molecular association, regulation	cell cycle regulation	NBS1(INDUCES)		4042508	1	18	99	MDC1-NBS1 interaction regulates intra-S-phase checkpoint activation	
FLOT2	Cell adhesion	Q9Z2S9	83764	Flot2		rat	Y24	PHOSPHORYLATION	1270903	GGCCGSDyKQYVFGG	Band_7		cell motility, altered; cytoskeletal reorganization			9297	1	0	0		
NOX5 iso4	EC 1.6.3.-; Membrane protein, integral; Membrane protein, multi-pass; Oxidoreductase	Q96PH1-4	79400	NOX5	15q23	human	T494	PHOSPHORYLATION	472625	KRLSRSVtMRKSQRS	FAD_binding_8	enzymatic activity, induced				9185	3	0	0		
CRY1	DNA binding protein; Lyase; Transcription, coactivator/corepressor	P97784	12952	Cry1		mouse	S280	PHOSPHORYLATION	11952907	YKKVKKNsSPPLSLY	FAD_binding_7	protein degradation; molecular association, regulation		Per2(INDUCES); FBXL3(INDUCES)		11419372	1	0	0		
SMPD3	EC 3.1.4.12; Lipid Metabolism - sphingolipid; Membrane protein, integral; Phospholipase	Q9JJY3	58994	Smpd3		mouse	S292	PHOSPHORYLATION	4780079	GDSGSLGsPSASRES		protein stabilization; enzymatic activity, induced				22463914	1	8	4		
MuSK	EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Protein kinase, TK; Protein kinase, tyrosine (receptor)	Q62838		Musk		rat	Y754	PHOSPHORYLATION	2848302	RNIYSADyYKADGND	Pkinase_Tyr	phosphorylation; enzymatic activity, induced				2848000	1	2	0	 promotes MuSK phosphorylation; promotes AChRb clustering and phosphorylation	
STX1A	Membrane protein, integral; Vesicle protein	Q16623	6804	STX1A	7q11.23	human	S14	PHOSPHORYLATION	451261	ELRTAKDsDDDDDVA	MCPsignal; ApoLp-III	molecular association, regulation	exocytosis, altered	STXBP1(DISRUPTS)		10353927	4	12	4		
HAND1	Cell development/differentiation; DNA binding protein; Transcription factor	Q64279	15110	Hand1		mouse	S109	PHOSPHORYLATION	12518702	KERRRTEsINSAFAE	HLH	intracellular localization; protein conformation	cell differentiation, altered			12482412	1	0	0	release from nucleolus, dimerization	
TNNI3	Actin binding protein; Motility/polarity/chemotaxis; Motor protein	P23693	29248	Tnni3		rat	S43	PHOSPHORYLATION	450690	AKKKSKIsASRKLQL			cell motility, altered			2703100	18	1	0	heart contractility and relaxation	
PKCI	Cell adhesion; Cell development/differentiation; EC 2.7.11.13; EC 3.-.-.-; KINASE; Kinase, protein; Motility/polarity/chemotaxis; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor)	F1M7Y5	84006	Prkci		rat	Y265	PHOSPHORYLATION	450076	RVIGRGSyAKVLLVR	Pkinase	intracellular localization		KPNB1(INDUCES)		8303	2	0	0		
LPP	Adaptor/scaffold; Cytoskeletal protein; Motility/polarity/chemotaxis	Q8BFW7	210126	Lpp		mouse	Y333	PHOSPHORYLATION	463381	TWKREAAyAPPASGN			cell cycle regulation; cell motility, altered			2790302	0	2	21		
TSC2 iso2	Cell cycle regulation; GTPase activating protein, misc.; Nuclear receptor co-regulator; Tumor suppressor	P49816-2	24855	Tsc2		rat	S1338	PHOSPHORYLATION	450215	VDLSFQPsQPLSKSS		phosphorylation	apoptosis, altered; cell growth, altered			2902	2	0	1		
RapGEF1	Guanine nucleotide exchange factor, Ras; Motility/polarity/chemotaxis	Q13905	2889	RAPGEF1	9q34.3	human	Y504	PHOSPHORYLATION	448393	APIPSVPyAPFAAIL		activity, induced; intracellular localization; phosphorylation	cell cycle regulation; apoptosis, altered; transcription, altered			14780514; 1759; 8322; 4140	7	0	0		
Rb	Nuclear receptor co-regulator; Transcription, coactivator/corepressor; Tumor suppressor	P06400	5925	RB1	13q14.2	human	T826	PHOSPHORYLATION	447984	LPTPTKMtPRSRILV	Rb_C	molecular association, regulation	cell growth, altered	Elf-1(DISRUPTS); E2F1(DISRUPTS); Rb(INDUCES); TFDP1(DISRUPTS)		7267; 776; 777	12	18	51		
p53	Activator protein; DNA binding protein; Motility/polarity/chemotaxis; Nuclear receptor co-regulator; Transcription factor; Tumor suppressor	P02340	22059	Tp53		mouse	K314	ACETYLATION	458976	SASPPQKkKPLDGEY	P53_tetramer		apoptosis, inhibited; transcription, altered			8906	35	0	0	negatively regulates p53 apoptotic activities after DNA damage	
STAT5B	DNA binding protein; Transcription factor	P51692	6777	STAT5B	17q11.2	human	S193	PHOSPHORYLATION	483615	FGPLAQLsPQERLSR	STAT_alpha	molecular association, regulation	transcription, induced		DNA(INDUCES)	25082850	1	10	1		
MEF2C	DNA binding protein; Transcription factor	Q8CFN5	17260	Mef2c		mouse	T20	PHOSPHORYLATION	455602	DERNRQVtFTKRKFG	SRF-TF		apoptosis, inhibited; transcription, altered			5542	1	0	0		
AMPKB1	Autophagy; Protein kinase, regulatory subunit	P80386	83803	Prkab1		rat	S25	PHOSPHORYLATION	448112	KTPRRDSsGGTKDGD		intracellular localization				1677	3	1	4		
Ikaros	C2H2-type zinc finger protein; DNA binding protein; Transcription factor	Q03267	22778	Ikzf1		mouse	S214	PHOSPHORYLATION	28735107	RSYKQRSsLEEHKER		molecular association, regulation; intracellular localization	transcription, induced		DNA(INDUCES)	28722169	1	1	0	nuclear localization, ITGA4, MDM1, EIF4E3, KIF23, TNFAIP8L2 DNA binding/transcription  inhibited by BTK siRNA	
SLC4A1	Membrane protein, integral; Membrane protein, multi-pass; Transporter	P02730	6521	SLC4A1	17q21.31	human	Y359	PHOSPHORYLATION	455384	AKPDSSFyKGLDLNG		molecular association, regulation; intracellular localization; phosphorylation		SHP-2(INDUCES)		8342; 4651313	5	4	49		
TH	Amino Acid Metabolism - tyrosine; EC 1.14.16.2; Endoplasmic reticulum; Mitochondrial; Oxidoreductase; Vesicle protein	P07101	7054	TH	11p15.5	human	S62	PHOSPHORYLATION	448544	SYTPTPRsPRFIGRR	TOH_N	enzymatic activity, induced				7484	32	5	0		
TPM1	Actin binding protein; Motility/polarity/chemotaxis; Motor protein	P58772		LOC100125989		rabbit	S283	PHOSPHORYLATION	451804	HALNDMTsI______	Tropomyosin; AAA_13; ERM; Reo_sigmaC; Laminin_I; ATG16; SlyX	molecular association, regulation	cytoskeletal reorganization	TPM1(INDUCES)		3190	8	10	83	sedimentation and viscometry methods have been used to describe the head-to-tail interaction of TPM1 protein	
SYT12	Membrane protein, integral; Vesicle protein	P97610	191595	Syt12		rat	S97	PHOSPHORYLATION	473040	GPPSRKGsLSIEDTF			exocytosis, altered			9191	2	0	0	increases spontaneous neurotransmitter release 	
ANXA1	Calcium-binding protein; Lipid binding protein	P10107	16952	Anxa1		mouse	S27	PHOSPHORYLATION	447972	EYVQAVKsYKGGPGS		intracellular localization				7966	4	0	0		
perilipin	Lipid binding protein	Q8CGN5	103968	Plin1		mouse	S81	PHOSPHORYLATION	450079	EPVVRRLsTQFTAAN	Perilipin	molecular association, regulation		HSL(INDUCES)		11424203	2	3	15		
SPRY2	Adaptor/scaffold; Inhibitor protein; Motility/polarity/chemotaxis	O43597	10253	SPRY2	13q31.1	human	Y283	PHOSPHORYLATION	3978700	LKLCQGCyDRVNRPG	Sprouty	activity, inhibited; phosphorylation	transcription, altered			4413	1	0	0		
KIF2C	Cancer Testis Antigen (CTA); Microtubule binding protein; Motility/polarity/chemotaxis; Motor protein	Q91636	380006	kif2c		frog	S110	PHOSPHORYLATION	2132101	KEVAAKNsLLSESGA		molecular association, regulation; intracellular localization	cytoskeletal reorganization		DNA(INDUCES)	3361009	1	0	0		
SYN1	Vesicle protein	P09951	24949	Syn1		rat	S9	PHOSPHORYLATION	448378	NYLRRRLsDSNFMAN	Synapsin_N	activity, induced; intracellular localization				11424214; 2989	17	5	2		
Hck	EC 2.7.10.2; KINASE; Kinase, protein; Protein kinase, TK; Protein kinase, tyrosine (non-receptor)	P08103	15162	Hck		mouse	Y409	PHOSPHORYLATION	448168	RIIEDNEyTAREGAK	Pkinase_Tyr	enzymatic activity, induced				1653	3	44	2066		
HIF1A	Autophagy; DNA binding protein; Transcription factor	Q16665	3091	HIF1A	14q23.2	human	S696	PHOSPHORYLATION	17595900	NVLSVALsQRTTVPE		protein stabilization	transcription, altered			17431539	1	1	0	required for the hypoxic regulation of the mTOR pathway	
rhodopsin	GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR	P02699	509933	RHO		cow	S334	PHOSPHORYLATION	448677	PLGDDEAsTTVSKTE		molecular association, regulation; protein conformation		SAG(INDUCES)		3621	7	5	0	Computational and in vitro data. S343 may be a weaker interaction.	
Cdc25A	EC 3.1.3.48; Motility/polarity/chemotaxis; PHOSPHATASE; Protein phosphatase, dual-specificity	P30304	993	CDC25A	3p21	human	S116	PHOSPHORYLATION	449977	PQKLLGCsPALKRSH	M-inducer_phosp	protein stabilization	cell cycle regulation	CDK1(INDUCES)		2535	2	3	0		
PTP1B	EC 3.1.3.48; Motility/polarity/chemotaxis; PHOSPHATASE; Phosphatase; Protein phosphatase, tyrosine (non-receptor)	P18031	5770	PTPN1	20q13.1-q13.2	human	Y66	PHOSPHORYLATION	447812	LHQEDNDyINASLIK	Y_phosphatase	molecular association, regulation; enzymatic activity, induced		InsR(INDUCES)		2178; 1397	3	1	48		
BRF1	Transcription factor	Q07352	677	ZFP36L1	14q22-q24	human	S54	PHOSPHORYLATION	2475300	GGFPRRHsVTLPSSK	Tis11B_N	molecular association, regulation	transcription, altered	14-3-3 beta(INDUCES)		2451820	1	17	13	inhibits BRF1-dependent AMD ( ARE-mediated mRNA decay)	
Snail1	C2H2-type zinc finger protein; Transcription factor	O95863	6615	SNAI1	20q13.2	human	S246	PHOSPHORYLATION	455616	QACARTFsRMSLLHK	zf-H2C2_2; CxxC_CxxC_SSSS	intracellular localization	transcription, altered			5502	1	0	0		
TNNI3	Actin binding protein; Motility/polarity/chemotaxis; Motor protein	P23693	29248	Tnni3		rat	S23	PHOSPHORYLATION	448423	PAPVRRRsSANYRAY	Troponin-I_N	activity, inhibited	cell motility, altered; cytoskeletal reorganization			4313625; 7201; 2703100	37	4	11	heart contractility and relaxation; regulates cardiac contractile function; accelerated relaxation during prolonged activation by endothelin	
PAK6	EC 2.7.11.1; KINASE; Kinase, protein; Nuclear receptor co-regulator; Protein kinase, STE; Protein kinase, Ser/Thr (non-receptor)	Q9NQU5	56924	PAK6	15q14	human	Y566	PHOSPHORYLATION	454426	KSLVGTPyWMAPEVI	Pkinase	enzymatic activity, induced				4293	1	0	0		
CACNA1C	Channel, calcium; Membrane protein, integral; Membrane protein, multi-pass	Q13936	775	CACNA1C	12p13.3	human	Y2217	PHOSPHORYLATION	1043301	ELQDSRVyVSSL___		activity, induced; molecular association, regulation		Src(INDUCES)		970052	2	0	0		
Gab1	Adaptor/scaffold; Motility/polarity/chemotaxis	Q13480	2549	GAB1	4q31.21	human	Y659	PHOSPHORYLATION	447949	VADERVDyVVVDQQK		molecular association, regulation	cell cycle regulation	SHP-2(INDUCES)		2319	5	26	1465	Binding of SHP-2 to Gab1 leads to ERK activation.	
E2A	DNA binding protein; Transcription factor	P15923	6929	TCF3	19p13.3	human	S139	PHOSPHORYLATION	455905	LNSPGPLsPSGMKGT			cell growth, altered			6389	2	3	0		
Myt1	EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, Other; Protein kinase, dual-specificity	Q99640	9088	PKMYT1	16p13.3	human	S416	PHOSPHORYLATION	11331004	PPATPPGsPPCSLLL		molecular association, regulation		Pin1(INDUCES)		7981800	1	0	0		
p63	DNA binding protein; Transcription factor	Q9H3D4	8626	TP63	3q28	human	Y149	PHOSPHORYLATION	452168	SVTAPSPyAQPSSTF		protein stabilization	transcription, altered			10353933	1	0	0		
PLD1 iso2	EC 3.1.4.4; Lipid Metabolism - ether lipid; Lipid Metabolism - glycerophospholipid; Motility/polarity/chemotaxis; Phospholipase	P70496-2	25096	Pld1		rat	S561	PHOSPHORYLATION	448574	SRKFSKFsLYRQLHR		enzymatic activity, induced				1392; 1391	3	0	0		
AA-NAT	ACETYLTRANSFERASE; Acetyltransferase; Amino Acid Metabolism - tryptophan; EC 2.3.1.87	Q29495	443531	AANAT		sheep	S205	PHOSPHORYLATION	452142	HAALRRNsDR_____		protein stabilization; molecular association, regulation; enzymatic activity, inhibited		14-3-3 beta(INDUCES); 14-3-3 zeta(INDUCES)		4399; 8210; 4651306	2	0	1		
claudin 3	Cytoskeletal protein; Membrane protein, integral; Membrane protein, multi-pass	O15551	1365	CLDN3	7q11.23	human	T192	PHOSPHORYLATION	455751	PPREKKYtATKVVYS		intracellular localization; activity, inhibited	cell adhesion, altered			5801	1	0	0	cell adhesion = tight junctions	
Tyk2	EC 2.7.10.2; KINASE; Kinase, protein; Protein kinase, TK; Protein kinase, tyrosine (non-receptor)	P29597	7297	TYK2	19p13.2	human	Y1054	PHOSPHORYLATION	447499	AVPEGHEyYRVREDG	Pkinase_Tyr	enzymatic activity, induced				801	5	2	59		
ASCL1	DNA binding protein; Transcription factor	Q02067	17172	Ascl1		mouse	S150	PHOSPHORYLATION	453455	GAANKKMsKVETLRS	HLH	protein stabilization; molecular association, regulation	transcription, inhibited	E2A iso2(INDUCES)		4153	1	0	0		
raptor	Adaptor/scaffold	Q8K4Q0	74370	Rptor		mouse	S792	PHOSPHORYLATION	2314600	DKMRRVSsYSALNSL		molecular association, regulation	cell cycle regulation	14-3-3 zeta(INDUCES); 14-3-3 gamma(INDUCES)		2314200	16	2	0		
Snail1	C2H2-type zinc finger protein; Transcription factor	O95863	6615	SNAI1	20q13.2	human	S119	PHOSPHORYLATION	6097706	SFSSTSVsSLEAEAY	CAP_N	intracellular localization	cell motility, altered; transcription, altered			6066701; 6098000	2	0	0	Localization mediated by S107, S111, S115 and S119. 	
Gab2	Adaptor/scaffold	Q9UQC2	9846	GAB2	11q14.1	human	S210	PHOSPHORYLATION	4825112	AENARSAsFSQGTRA		molecular association, regulation; intracellular localization; activity, inhibited; phosphorylation	cell growth, altered	14-3-3 beta(INDUCES); Shc1(DISRUPTS); Grb2(DISRUPTS); EGFR(DISRUPTS)		6315402	2	4	7		
Shc1 iso2	Adaptor/scaffold; Apoptosis; Mitochondrial; Motility/polarity/chemotaxis	P29353-2	6464	SHC1	1q21	human	Y240	PHOSPHORYLATION	448510	EPPDHQYyNDFPGKE		activity, induced; molecular association, regulation; phosphorylation	cell motility, altered; cytoskeletal reorganization	SHIP(INDUCES); ZAP70(INDUCES); VAV1(INDUCES); Grb2(INDUCES)		762700; 8804; 783; 8168	24	14	919	f-actin cytoskeleton, chemotaxis.; promotes Shc phosphorylation	
prolactin	Cytokine; Motility/polarity/chemotaxis; Secreted; Secreted, signal peptide	P01239	280901	PRL		cow	S120	PHOSPHORYLATION	451505	LILGLLRsWNDPLYH	Hormone_1	protein conformation; activity, inhibited				8757	1	0	0		
CSK	EC 2.7.10.2; KINASE; Kinase, protein; Protein kinase, TK; Protein kinase, tyrosine (non-receptor)	P41240	1445	CSK	15q24.1	human	S364	PHOSPHORYLATION	448477	ALREKKFsTKSDVWS	Pkinase_Tyr	phosphorylation; enzymatic activity, induced		PKACA(INDUCES)		2011; 706	3	0	0	In vitro the presence of SH3 domain of CSK  greatly increases phosphotransferase activity of CSK. PKA mediated phosphorylation of S364 is independent of SH3 domain. 	
SIIR	Transcription initiation complex	Q15170	9338	TCEAL1	Xq22.1	human	S36	PHOSPHORYLATION	451217	PKSSPPRsSLRRSSP	BEX; Myticin-prepro		transcription, altered			3453	1	0	0	S36A/S37A mutation resulted in a substantial loss of LTR repression function suggesting that RSV LTR repression may be regulated by S36 and/or S37 phosphorylation.	
ROMK iso2	Channel, potassium; Membrane protein, integral; Membrane protein, multi-pass	P35560-2		Kcnj1		rat	S200	PHOSPHORYLATION	2461201	RVANLRKsLLIGSHI	IRK	activity, induced				2462000	5	0	0	phosphorylation of at least two serines necessary for channel activity	
PDGFRB	EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Protein kinase, TK; Protein kinase, tyrosine (receptor)	P09619	5159	PDGFRB	5q33.1	human	Y686	PHOSPHORYLATION	7437801	IITEYCRyGDLVDYL	Pkinase_Tyr	enzymatic activity, induced	cell motility, altered			7324304	1	1	1	in vitro	
CDC5L	DNA binding protein; Motility/polarity/chemotaxis; RNA processing; RNA splicing; Spliceosome; Transcription factor	Q99459	988	CDC5L	6p21	human	T411	PHOSPHORYLATION	469436	TPNTVLStPFRTPSN	Myb_Cef		RNA splicing, altered			3309529	2	5	34		
HDAC5	EC 3.5.1.98; Hydrolase	Q9Z2V6	15184	Hdac5		mouse	S488	PHOSPHORYLATION	447996	RPLSRTQsSPLPQSP		molecular association, regulation		14-3-3 epsilon(INDUCES); MEF2C(DISRUPTS)		1117	18	3	4		
Shc3 iso2	Adaptor/scaffold; Motility/polarity/chemotaxis	Q92529-2	53358	SHC3	9q22.1	human	Y218	PHOSPHORYLATION	451254	GDGSDHPyYNSIPSK		molecular association, regulation		Crk(INDUCES); RapGEF1(INDUCES)		3475	3	0	3		
CACNA1C	Channel, calcium; Membrane protein, integral; Membrane protein, multi-pass	P15381	100101555	CACB		rabbit	S1575	PHOSPHORYLATION	467228	VACKRLVsMNMPLNS		activity, induced				8157	2	0	0		
MRLC2	Contractile protein	Q3THE2	67938	Myl12b		mouse	S20	PHOSPHORYLATION	448595	KRPQRATsNVFAMFD	2-Hacid_dh_C; EF_hand_5	activity, induced; molecular association, regulation	cytoskeletal reorganization			6842208	50	28	282	movement of actin filaments to spindle poles	
IRS1	Adaptor/scaffold; Motility/polarity/chemotaxis	P35568	3667	IRS1	2q36	human	S270	PHOSPHORYLATION	447566	EFRPRSKsQSSSNCS		molecular association, regulation		14-3-3 beta(INDUCES)		1137	3	4	26		
GH receptor	Membrane protein, integral; Receptor, cytokine	NP_999419	397488	GHR		pig	Y566	PHOSPHORYLATION	486257	SFNQEDIyITTESLT	GHBP		transcription, induced		DNA(INDUCES)	10144217	3	0	0		
GIRK4	Channel, potassium; Membrane protein, integral; Membrane protein, multi-pass	P48548	29713	Kcnj5		rat	S191	PHOSPHORYLATION	450684	GCMFVKIsQPKKRAE	IRK	activity, inhibited				3086	1	0	0	inhibition of channel open-state probability	
SHIP	EC 3.1.3.86; EC 3.1.3.n1; Motility/polarity/chemotaxis; Phosphatase, lipid	Q9ES52	16331	Inpp5d		mouse	Y1021	PHOSPHORYLATION	448865	EMFENPLyGSVSSFP		molecular association, regulation		Shc1(INDUCES); SHIP(INDUCES); Dok1(INDUCES)		25255526; 2580; 2583	4	8	202		
Grb2	Adaptor/scaffold; Cell development/differentiation; Motility/polarity/chemotaxis	P62993	2885	GRB2	17q24-q25	human	Y52	PHOSPHORYLATION	7388002	DGFIPKNyIEMKPHP			cell growth, altered			7324303	1	0	0	regulates cell proliferation	
caldesmon	Actin binding protein	Q62736	25687	Cald1		rat	S497	PHOSPHORYLATION	448465	KSPDGNKsPAPKPSD	Caldesmon	intracellular localization	cytoskeletal reorganization			7289	7	9	0		
NDEL1	Microtubule binding protein; Protease	Q9ERR1	83431	Ndel1		mouse	S242	PHOSPHORYLATION	3685801	IPNGFGTsPLTPSAR	NUDE_C	activity, induced; intracellular localization	cell motility, altered			2425202	2	2	1	Cdc42 activation	
CDH5	Cell adhesion; Membrane protein, integral; Motility/polarity/chemotaxis	P55284	12562	Cdh5		mouse	Y733	PHOSPHORYLATION	2028402	DTLHIYGyEGAESIA	Cadherin_C		cell motility, altered			1968313	1	0	1	affects cell migration and increased endothelial cell barrier permeability	
SHPS1	Cell adhesion; Cell surface; Membrane protein, integral; Motility/polarity/chemotaxis; Receptor, misc.	P78324	140885	SIRPA	20p13	human	Y429	PHOSPHORYLATION	458557	QDTNDITyADLNLPK		phosphorylation				3205	3	7	47	Mutation of these 4 tyrosines does not affect JAK2 binding.  However, overexpression of the WT SHPS1 but not the 4 tyrosine to phenylalanine mutation reduces tyrosine phosphorylation of Jak2, STAT5B, and STAT3 and activation of Erk1/2 in response to growth hormone.  Does not affect STAT3 tyrosine phosphorylation in response to LIF agonist.	
NPY1R	GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR	P21555	29358	Npy1r		rat	S375	PHOSPHORYLATION	2815305	PVAFKKIsMNDNEKI		receptor internalization, altered				4358	1	2	0	may be an artifact of the truncation mutants	
SLC12A3	Membrane protein, integral; Membrane protein, multi-pass; Transporter	P55017	6559	SLC12A3	16q13	human	T60	PHOSPHORYLATION	469617	MRTFGYNtIDVVPTY	AA_permease_N	activity, induced; molecular association, regulation		ADD3(DISRUPTS)		17714504; 2195492	14	3	0	ADD3 stimulates SLC12A3 activity	
CD19	Cell surface; Membrane protein, integral	P15391	930	CD19	16p11.2	human	Y378	PHOSPHORYLATION	463123	LGGTAPSyGNPSSDV		activity, induced; molecular association, regulation		SOS1(INDUCES); Grb2(INDUCES)		8326	1	0	4		
EphA3	EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Protein kinase, TK; Protein kinase, tyrosine (receptor)	P29320	2042	EPHA3	3p11.2	human	Y742	PHOSPHORYLATION	25290781	KYLSDMGyVHRDLAA	Pkinase_Tyr	protein conformation; enzymatic activity, induced				25779406	1	1	1		
NFAT1	DNA binding protein; Transcription factor	Q60591	18019	Nfatc2		mouse	S278	PHOSPHORYLATION	447851	PQRSRSPsPQPSPHV			transcription, inhibited			1188	0	1	0		
TGFBR2	EC 2.7.11.30; KINASE; Kinase, protein; Membrane protein, integral; Protein kinase, Ser/Thr (receptor); Protein kinase, TKL	P37173	7048	TGFBR2	3p22	human	Y284	PHOSPHORYLATION	479864	KIFPYEEyASWKTEK	Pkinase	molecular association, regulation	cytoskeletal reorganization; cell growth, altered	Shc1(INDUCES); Grb2(INDUCES)		11490; 2195723	2	0	0	important for TGF beta -induced cell invasion; stimulates cell invasion;  important for TGF-beta-mediated activation of p38MAPK	
ITGB1	Cell adhesion; Cell surface; Membrane protein, integral; Motility/polarity/chemotaxis; Receptor, misc.	P09055	16412	Itgb1		mouse	Y783	PHOSPHORYLATION	447710	DTGENPIyKSAVTTV	Integrin_b_cyt		cell motility, altered; cell adhesion, altered			2701; 1686	5	24	1162		
ATF-2	C2H2-type zinc finger protein; Transcription factor	P15336	1386	ATF2	2q32	human	S498	PHOSPHORYLATION	455783	QIVMAPSsQSQPSGS		intracellular localization				5799	1	0	0	S472/480 are important for ionizing radiation-induced S phase checkpoint control	
MOK	EC 2.7.11.22; KINASE; Kinase, protein; Protein kinase, CMGC; Protein kinase, Ser/Thr (non-receptor)	Q9UQ07	5891	MOK	14q32	human	Y161	PHOSPHORYLATION	450006	SKQPYTEyISTRWYR	Pkinase	activity, induced				2553	1	0	0	While the authors did not prove that these sites were phosphorylated, mutation of both T159 and Y161, located in the activation loop, abolished the enzymatic activity of the kinase.	
PHLPP	EC 3.1.3.16; PHOSPHATASE; Protein phosphatase, Ser/Thr (non-receptor)	O60346	23239	PHLPP1	18q21.33	human	T1363	PHOSPHORYLATION	22769303	HVQSVLLtPQDEFFI	PP2C	protein degradation				22767400	1	1	0	PHLPP phosphorylation induces degradation and Akt1 activation negatively regulates degradation. 	
SLC22A1	Membrane protein, integral; Membrane protein, multi-pass; Transporter	Q63089	24904	Slc22a1		rat	T550	PHOSPHORYLATION	455614	TIYLQVQtGKSSST_		activity, induced				5524	1	0	0	stimulates ASP+ uptake	
HEC1	Cell cycle regulation	O14777	10403	NDC80	18p11.32	human	S55	PHOSPHORYLATION	459763	PTSERKVsLFGKRTS	Ndc80_HEC		cell cycle regulation			9229	2	5	0	mutation of six N-terminal residues (S5,S15,S44,T49,S55 and S69) to alanines interferes with mitosis	
HIF1A	Autophagy; DNA binding protein; Transcription factor	Q16665	3091	HIF1A	14q23.2	human	T796	PHOSPHORYLATION	451302	ESGLPQLtSYDCEVN	HIF-1a_CTAD		transcription, induced			3526	1	0	0		
AML3 iso5	DNA binding protein; Transcription factor	Q08775-5	12393	Runx2		mouse	T326	PHOSPHORYLATION	14694701	SPSIHSTtPLSSTRG		activity, induced	transcription, induced			14562606	1	0	0		
Ets-1	DNA binding protein; Motility/polarity/chemotaxis; Transcription factor	P14921	2113	ETS1	11q23.3	human	S282	PHOSPHORYLATION	449317	NSLQRVPsYDSFDSE		molecular association, regulation; activity, inhibited	transcription, inhibited		DNA(DISRUPTS)	2182	3	4	79		
p53	Activator protein; DNA binding protein; Motility/polarity/chemotaxis; Nuclear receptor co-regulator; Transcription factor; Tumor suppressor	P04637	7157	TP53	17p13.1	human	S392	PHOSPHORYLATION	447535	FKTEGPDsD______		activity, induced; protein stabilization; molecular association, regulation; intracellular localization; protein conformation; activity, inhibited; phosphorylation	cell cycle regulation; apoptosis, altered; cell growth, inhibited; apoptosis, induced; transcription, altered	MDM2(DISRUPTS); CDK1(DISRUPTS); p21Cip1(INDUCES); NFkB-p65(INDUCES)	DNA(INDUCES)	5197; 7991101; 2619003; 7049; 26341743; 2665607; 19016925; 7309829; 5250; 2624102; 4971005; 730	87	6	0		
IRS1	Adaptor/scaffold; Motility/polarity/chemotaxis	P35569	16367	Irs1		mouse	S731	PHOSPHORYLATION	2352500	TGDYMNMsPVGDSNT		molecular association, regulation		PIK3C2A(DISRUPTS)		4032	1	0	0		
NMDAR2B	Channel, calcium; Channel, ligand-gated; Membrane protein, integral; Membrane protein, multi-pass	Q00960	24410	Grin2b		rat	S1303	PHOSPHORYLATION	450171	NKLRRQHsYDTFVDL	NMDAR2_C	molecular association, regulation; intracellular localization		CAMK2A(DISRUPTS)		8684	20	9	12		
MUC1	Actin binding protein; Cell adhesion; Membrane protein, integral; Motility/polarity/chemotaxis; Nuclear receptor co-regulator	P15941	4582	MUC1	1q21	human	Y1218	PHOSPHORYLATION	473759	TYHTHGRyVPPSSTD	IncA	intracellular localization	cell motility, altered			11964	1	2	55	nuclear localization;  Phosphorylation enhanced invasion in vitro, through Matrigel. 	
SETD8	Amino Acid Metabolism - lysine degradation; EC 2.1.1.-; EC 2.1.1.43; METHYLTRANSFERASE; Methyltransferase; Methyltransferase, protein lysine	Q9NQR1	387893	SETD8	12q24.31	human	S100	PHOSPHORYLATION	3213381	SKIYSYMsPNKCSGM		protein stabilization; ubiquitination; intracellular localization	cell cycle regulation			15755111	1	3	0	phosphorylation of this site results in the removal of SETD8 from mitotic chromosomes;  inhibits SETD8 ubiquitination	
iNOS	Amino Acid Metabolism - arginine and proline; EC 1.14.13.39; Oxidoreductase	P35228	4843	NOS2	17q11.2-q12	human	Y151	PHOSPHORYLATION	457593	IEFVNQYyGSFKEAK	NO_synthase	intracellular localization; enzymatic activity, inhibited				7115	2	0	0		
Borealin	Cell cycle regulation	Q53HL2	55143	CDCA8	1p34.3	human	T230	PHOSPHORYLATION	4203200	DSKEIFLtVPVGGGE	Borealin	molecular association, regulation; protein conformation; phosphorylation	cell cycle regulation; cytoskeletal reorganization	Borealin(INDUCES)		4201803; 9721200	2	0	0	 stimulates phosphorylation of CENPA S7; important for chromosome alignment; chromosome alignment in mitosis	
FOXO1A	DNA binding protein; Nuclear receptor co-regulator; Transcription factor	Q12778	2308	FOXO1	13q14.1	human	S256	PHOSPHORYLATION	448075	SPRRRAAsMDNNSKF	Fork_head	protein degradation; molecular association, regulation; intracellular localization; activity, inhibited; phosphorylation	transcription, altered; transcription, inhibited	14-3-3 beta(INDUCES); SKP2(INDUCES)	DNA(DISRUPTS)	6791; 15022750; 4904514; 6792; 676; 12525214; 677; 5195; 2463200; 3405	64	3	35		
ChaK2	Channel, cation; EC 2.7.11.1; KINASE; Kinase, protein; Membrane protein, integral; Membrane protein, multi-pass; Protein kinase, ATYPICAL; Protein kinase, atypical	Q9BX84	140803	TRPM6	9q21.13	human	T1851	PHOSPHORYLATION	2255402	FNQVKPQtIPYTPRF	Alpha_kinase	activity, inhibited				2195498	2	1	0	RACK1 induced inhibition of channel activity is dependent on T1851 phosphorylation.	
Abl	EC 2.7.1.112; EC 2.7.10.2; KINASE; Kinase, protein; Protein kinase, TK; Protein kinase, tyrosine (non-receptor)	P00519	25	ABL1	9q34.1	human	Y226	PHOSPHORYLATION	450303	KRNKPTVyGVSPNYD			cell differentiation, altered			15031343	15	10	306	represses osteoblast differentiation	
Hic-5	Motility/polarity/chemotaxis; Nuclear receptor co-regulator; Transcription, coactivator/corepressor	Q62219	21804	Tgfb1i1		mouse	Y60	PHOSPHORYLATION	450964	TGDKDHLySTVCKPR	Paxillin		cytoskeletal reorganization			6852	3	3	20	phosphorylation of this site after EGF induction leads to reduction of Rac activity and formation of lamellipodia 	
PKG1	EC 2.7.11.12; KINASE; Kinase, protein; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor)	Q13976	5592	PRKG1	10q11.2	human	T517	PHOSPHORYLATION	452153	GFGKKTWtFCGTPEY	Pkinase	phosphorylation; enzymatic activity, induced	transcription, altered			8703	2	5	16	promotes phosphorylation of p38 and ATF2-dependent transcription	
RIP140	Nuclear receptor co-regulator; Transcription, coactivator/corepressor	Q8CBD1	268903	Nrip1		mouse	T202	PHOSPHORYLATION	456686	KDQKSGPtLPDVTPN	Hexokinase_1	activity, induced				6686	3	1	0		
IL-8R B	GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR; Receptor, cytokine	P25025	3579	CXCR2	2q35	human	S347	PHOSPHORYLATION	451046	LPKDSRPsFVGSSSG		protein degradation; receptor desensitization, altered; receptor internalization, altered				3279	1	2	5		
ORC2	DNA replication	Q13416	4999	ORC2	2q33	human	T226	PHOSPHORYLATION	7320974	SAPVGKEtPSKRMKR		molecular association, regulation	cell cycle regulation		DNA(DISRUPTS)	23260340	2	8	14	dissociates Orc2-5 subunits from chromatin and replication origins	
ROCK2	EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor)	O75116	9475	ROCK2	2p24	human	Y722	PHOSPHORYLATION	464192	LADKNKIyESIEEAK		molecular association, regulation; enzymatic activity, inhibited	cell adhesion, altered	RhoA(DISRUPTS)		2884003	2	3	80	GTP-bound RhoA	
AurA	EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor)	O14965	6790	AURKA	20q13	human	S342	PHOSPHORYLATION	457608	QETYKRIsRVEFTFP	Pkinase	enzymatic activity, induced	cell cycle regulation; cytoskeletal reorganization			6991	3	2	0		
ADCY6	Adenylyl cyclase; EC 4.6.1.1; Lyase; Membrane protein, integral; Membrane protein, multi-pass; Nucleotide Metabolism - purine	AAA40678	25289	Adcy6		rat	S674	PHOSPHORYLATION	455529	EDLEKKYsRKVDPRF	DUF1053	enzymatic activity, inhibited				8211; 3690	2	0	0	decreases potentiation	
ITGB1	Cell adhesion; Cell surface; Membrane protein, integral; Motility/polarity/chemotaxis; Receptor, misc.	P05556	3688	ITGB1	10p11.2	human	T789	PHOSPHORYLATION	447709	IYKSAVTtVVNPKYE	Integrin_b_cyt	activity, induced; protein conformation	cell motility, altered; cell adhesion, altered			6636; 6277008; 3222	8	1	1	induce vascular invasion	
HER2	EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Protein kinase, TK; Protein kinase, tyrosine (receptor)	P04626	2064	ERBB2	17q12	human	T1172	PHOSPHORYLATION	451643	ATLERPKtLSPGKNG		receptor desensitization, altered				3763	1	0	1		
GLI3	C2H2-type zinc finger protein; Transcription factor	P10071	2737	GLI3	7p13	human	S849	PHOSPHORYLATION	7998355	NMLNRRDsSASTISS		protein processing	transcription, inhibited			25779400	1	1	4		
Ron	EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Protein kinase, TK; Protein kinase, tyrosine (receptor)	Q04912	4486	MST1R	3p21.3	human	Y1238	PHOSPHORYLATION	454933	RDILDREyYSVQQHR	Pkinase_Tyr	protein conformation; enzymatic activity, induced				17630300	0	6	139	Crystal structure of mutant M1254T suggests that T1238 may be cis phosphorylated which could lead to constitutive activation. 	
TRPV1	Channel, cation; Membrane protein, integral; Membrane protein, multi-pass; Receptor, misc.	Q704Y3	193034	Trpv1		mouse	T145	PHOSPHORYLATION	456216	QKSKKRLtDSEFKDP		receptor desensitization, altered				8949	5	0	0		
Rb-like 1	Transcription, coactivator/corepressor; Tumor suppressor	P28749	5933	RBL1	20q11.2	human	S975	PHOSPHORYLATION	450986	HIKQQPGsPRRISQQ	Rb_C		cell growth, altered			3519	2	0	1		
Ets-1	DNA binding protein; Motility/polarity/chemotaxis; Transcription factor	P13474	396235	ETS1		chicken	S257	PHOSPHORYLATION	449319	DSFESIEsYDSCDRL		activity, inhibited				3214	2	0	0	The in vitro interaction of  Ets-1 with a high-affinity Ets binding site was assayed with EMSA.	
Grb10	Adaptor/scaffold	Q13322	2887	GRB10	7p12.2	human	S476	PHOSPHORYLATION	455870	MNILGSQsPLHPSTL		protein stabilization; activity, inhibited				19044700; 6334	3	7	9		
eNOS	Amino Acid Metabolism - arginine and proline; EC 1.14.13.39; Oxidoreductase	P29473	287024	NOS3		cow	T497	PHOSPHORYLATION	447885	AGITRKKtFKEVANA		enzymatic activity, inhibited				7217; 5479; 6219	56	1	1		
NFkB-p65	DNA binding protein; Nuclear receptor co-regulator; Transcription factor	Q04206	5970	RELA	11q13	human	S468	PHOSPHORYLATION	451145	AVFTDLAsVDNSEFQ		activity, induced; protein degradation; ubiquitination; intracellular localization; activity, inhibited	transcription, induced; transcription, inhibited; transcription, altered	COMMD1(INDUCES); CUL2(INDUCES)		22632300; 18378510; 1910504; 4966807; 4214800; 4244	13	0	0	Regulatory function of phosphorylation is dependent on individual regulated genes.; TNF induced degradation	
DOR-1	GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR	P32300	18386	Oprd1		mouse	T161	PHOSPHORYLATION	455533	VKALDFRtPAKAKLI	7tm_1	receptor desensitization, altered				5413	3	0	0		
YAP1	Transcription, coactivator/corepressor	P46937	10413	YAP1	11q13	human	S127	PHOSPHORYLATION	448847	PQHVRAHsSPASLQL		molecular association, regulation; intracellular localization	apoptosis, altered; cell growth, inhibited; apoptosis, inhibited; cell adhesion, altered; transcription, altered; cell growth, altered	14-3-3 eta(INDUCES)		22343611; 15658717; 2016; 25255500; 14146313; 6420302	25	14	164		
DYN2	EC 3.6.5.5; Hydrolase; Microtubule binding protein; Motility/polarity/chemotaxis; Vesicle protein	P39054	13430	Dnm2		mouse	Y597	PHOSPHORYLATION	451200	NTEQRNVyKDLRQIE	PH; KcnmB2_inactiv		cytoskeletal reorganization			20834132	3	1	2	promotes focal adhesion turnover	
SORT1	Membrane protein, integral; Receptor, misc.	Q99523	6272	SORT1	1p13.3|1p21.3-p13.1	human	S825	PHOSPHORYLATION	468808	KSGYHDDsDEDLLE_		molecular association, regulation		GGA1(INDUCES)		11484411	0	21	23		
KIBRA	Adaptor/scaffold	Q8IX03	23286	WWC1	5q34	human	S539	PHOSPHORYLATION	20751200	TSLSPRSsLSSPSPP		molecular association, regulation	cell cycle regulation	merlin(INDUCES)		25712650; 20744402	3	0	0		
Cx43	Channel, misc.; Membrane protein, integral; Membrane protein, multi-pass; Motility/polarity/chemotaxis	P08050	24392	Gja1		rat	S279	PHOSPHORYLATION	448853	SSPTAPLsPMSPPGY		activity, inhibited	endocytosis, induced			27519663; 2192	17	1	0	Phosphorylation of S279  impairs Cx43 assembly into gap junctions. 	
GNA15	G protein; G protein, heterotrimeric; G protein, heterotrimeric alpha G(q)	P30679	2769	GNA15	19p13.3	human	S336	PHOSPHORYLATION	11380905	GSKKGARsRRLFSHY	G-alpha	activity, induced				10303913	1	0	0	GNA15 receptor mediated PLC-B  activation 	
PPP1CC	EC 3.1.3.16; Motility/polarity/chemotaxis; PHOSPHATASE; Protein phosphatase, Ser/Thr (non-receptor)	P36873	5501	PPP1CC	12q24.1-q24.2	human	T311	PHOSPHORYLATION	3913895	PNATRPVtPPRGMIT		enzymatic activity, inhibited				18378521	1	4	20		
4E-BP1	Translation; Translation initiation	Q13541	1978	EIF4EBP1	8p12	human	S112	PHOSPHORYLATION	447526	KRAGGEEsQFEMDI_	eIF_4EBP	molecular association, regulation; phosphorylation		eIF4E(DISRUPTS)		2063	5	3	15	Deletion of (QFEMDI) sequence affected phosphorlation of multiple phosphorylation sites. ; S111 did not affect binding to EIF4E. 	
TLE1	Transcription, coactivator/corepressor	Q04724	7088	TLE1	9q21.32	human	S286	PHOSPHORYLATION	5707650	LKKDASSsPASTASS		molecular association, regulation	transcription, induced		DNA(NOT_REPORTED)	12021306	1	12	1	mutation of this site weakens TLE1 interaction with chromatin and inhibits its anti-neurogenic activity 	
PR	DNA binding protein; Nuclear receptor	Q00175	18667	Pgr		mouse	S294	PHOSPHORYLATION	447987	SPIAPGRsPLATTVV	Prog_receptor	activity, induced; phosphorylation	transcription, altered	MSK1(INDUCES); ERK2(INDUCES); ERK1(INDUCES)		2669501	18	0	0		
NUP98 iso2	Motility/polarity/chemotaxis; Nucleoporin	P52948-2	4928	NUP98	11p15.5	human	S606	PHOSPHORYLATION	452729	RDSENLAsPSEYPEN		intracellular localization				18331300	1	36	6	as multiple sites (13PM) mutant 	
CCNE2	Activator protein; Cell cycle regulation	O96020	9134	CCNE2	8q22.1	human	S396	PHOSPHORYLATION	4271425	GIMTPPKsTEKPPGK		protein degradation; ubiquitination				5930031	1	0	0		
EpoR	EC 2.7.10.2; Membrane protein, integral; Receptor, cytokine	P14753	13857	Epor		mouse	Y367	PHOSPHORYLATION	449883	SEHAQDTyLVLDKWL		molecular association, regulation	apoptosis, altered; cell differentiation, altered; cell growth, altered	PLCG1(INDUCES)		6374; 12525207; 7397; 7450500; 2731; 3486	16	0	0	required for constitutive activation of STAT5 ; activates Stat5	
BORA	Activator protein	Q6PGQ7	79866	BORA	13q22.1	human	S252	PHOSPHORYLATION	7533203	SSGQFSSsPIQASAK		molecular association, regulation		PLK1(INDUCES)		7532700	1	0	1		
gp130	Membrane protein, integral; Receptor, cytokine	P40189	3572	IL6ST	5q11.2	human	S782	PHOSPHORYLATION	448180	QVFSRSEsTQPLLDS		protein degradation; receptor internalization, altered				7262; 1366	4	4	0		
cortactin	Actin binding protein; Cytoskeletal protein; Motility/polarity/chemotaxis	Q60598	13043	Cttn		mouse	Y482	PHOSPHORYLATION	447704	YQAEDDTyDGYESDL		molecular association, regulation	cell motility, induced; cytoskeletal reorganization	smMLCK(INDUCES)		25712657; 8392; 11502	16	1	3	invadopodia formation and extracellular matrix degredation; Tyr to Phe mutation of this site prevents FAK-mediated FA turnover	
PLD2	EC 3.1.4.4; Lipid Metabolism - ether lipid; Lipid Metabolism - glycerophospholipid; Motility/polarity/chemotaxis; Phospholipase	P97813	18806	Pld2		mouse	Y470	PHOSPHORYLATION	453412	GRWDDVQyRLTDLGD		intracellular localization				4130	1	0	0	Y14 F and YallF showed altered location in cytoplasm rather than at the plasmamembrane. 	
Cx43	Channel, misc.; Membrane protein, integral; Membrane protein, multi-pass; Motility/polarity/chemotaxis	P08050	24392	Gja1		rat	S330	PHOSPHORYLATION	449994	AGSTISNsHAQPFDF		intracellular localization	cell adhesion, altered			2541	7	10	0		
InsR	EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Protein kinase, TK; Protein kinase, tyrosine (receptor)	P15208	16337	Insr		mouse	Y1175	PHOSPHORYLATION	447680	FGMTRDIyETDYYRK	Pkinase_Tyr		cell cycle regulation; cell motility, altered			2790302	33	19	453		
p53	Activator protein; DNA binding protein; Motility/polarity/chemotaxis; Nuclear receptor co-regulator; Transcription factor; Tumor suppressor	P04637	7157	TP53	17p13.1	human	K370	UBIQUITINATION	464661	RAHSSHLkSKKGQST		protein degradation; intracellular localization	transcription, inhibited			12136; 7920	9	0	0	K370/372/373/381/382/386/R mutant shows 613-fold activation of p53	
K18	Cytoskeletal protein	P05784	16668	Krt18		mouse	S35	PHOSPHORYLATION	447733	RPASSAAsVYAGAGG		intracellular localization	cytoskeletal reorganization			1030	12	15	10		
hnRNP K	RNA binding protein; RNA splicing; Spliceosome	P61978	3190	HNRNPK	9q21.32-q21.33	human	S353	PHOSPHORYLATION	450147	DSAIDTWsPSEWQMA		activity, induced; intracellular localization	translation, altered; transcription, altered			1120; 1119	4	1	0		
IP3R2	Channel, calcium; Channel, ligand-gated; Membrane protein, integral; Membrane protein, multi-pass; Receptor, misc.	P29995		Itpr2		rat	S150	PHOSPHORYLATION	26415703	EKNAMRVsLDAAGNE		activity, inhibited				26341762	1	0	0	phosphorylation channel modulation (open probability is decreased)	
MafA	DNA binding protein; Transcription factor	Q8CF90	378435	Mafa		mouse	S49	PHOSPHORYLATION	1320400	CHRLPPGsLSSTPLS		molecular association, regulation		MafA(INDUCES)	DNA(NOT_REPORTED)	13326312	3	1	0		
MYO5A	Motility/polarity/chemotaxis; Motor protein	Q99104	17918	Myo5a		mouse	S1650	PHOSPHORYLATION	480053	GLRKRTSsIADEGTY		molecular association, regulation		ACTN1(INDUCES)		11790	2	10	9		
ENG	Membrane protein, integral; Motility/polarity/chemotaxis; Receptor, misc.	P17813	2022	ENG	9q34.11	human	S646	PHOSPHORYLATION	12064201	STNHSIGsTQSTPCS	DUF4199		cell motility, altered			12028130	1	0	0	regulates TGF-beta signaling via  ALK1/Smad1/5/8 pathway	
Fas	Apoptosis; Cell surface; Membrane protein, integral; Receptor, cytokine	P25445	355	FAS	10q24.1	human	Y291	PHOSPHORYLATION	455222	LHGKKEAyDTLIKDL	Peptidase_M73; Death	molecular association, regulation; intracellular localization	apoptosis, altered	Casp8(INDUCES); FADD(INDUCES); Fas(INDUCES)		9149; 4414	3	0	0	Y291 or Y232 is required for Fas oligomerization	
CD28	Cell surface; Membrane protein, integral	P10747	940	CD28	2q33	human	Y218	PHOSPHORYLATION	450285	PPRDFAAyRS_____		activity, induced; phosphorylation	transcription, induced; transcription, altered	NFkB-p65(INDUCES)		2932	3	3	201	In Y218F mutant  Vav phosphorylation is reduced. 	
coronin 1A	Cytoskeletal protein; Motility/polarity/chemotaxis	P31146	11151	CORO1A	16p11.2	human	T412	PHOSPHORYLATION	3995219	RVNRGLDtGRRRAAP	IncA; CENP-Q; DUF4140; PEP-utilisers_N	molecular association, regulation		ACTB(DISRUPTS)		27132474	1	0	4	 phosphorylated during phagocytosis ; reduce binding affinity of coronin 1A for G-actin	
FOXP3	C2H2-type zinc finger protein; Cell cycle regulation; DNA binding protein; Transcription factor	Q9BZS1	50943	FOXP3	Xp11.23	human	S418	PHOSPHORYLATION	27623902	LEFRKKRsQRPSRCS			cell growth, inhibited; transcription, induced		DNA(INDUCES)	27619330	1	0	0		
TIRAP	Adaptor/scaffold	P58753	114609	TIRAP	11q24.2	human	Y86	PHOSPHORYLATION	463808	SSRWSKDyDVCVCHS		activity, induced; molecular association, regulation; phosphorylation	transcription, altered	TLR4(DISRUPTS); MYD88(DISRUPTS); Btk(INDUCES)		7871; 1713124	2	0	0		
Cbl	Adaptor/scaffold; EC 6.3.2.-; EC 6.3.2.19; Ligase; Motility/polarity/chemotaxis; UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase	P22681	867	CBL	11q23.3	human	Y774	PHOSPHORYLATION	448531	SENEDDGyDVPKPPV		protein degradation; molecular association, regulation; phosphorylation	cell motility, altered; cell growth, altered	Src(INDUCES); Crk(INDUCES); VEGFR2(INDUCES)		6767; 4181; 2855903; 2012	11	1	249	The double mutant Y700/774F was used in this study; cCbl association with VEGFR2 is required for inhibition of PLCG1 phosphorylation. ; Src induces Cbl phosphorylation inducing Cbl degredation and alters EGFR desensitization.  	
GR	DNA binding protein; Mitochondrial; Nuclear receptor; Transcription factor	P06537	14815	Nr3c1		mouse	S220	PHOSPHORYLATION	447968	PGKETNEsPWRSDLL	GCR		transcription, induced			21683716	27	1	0		
SIAH2	EC 6.3.2.-; EC 6.3.2.19; Ligase; Transcription, coactivator/corepressor; UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase	Q06986	20439	Siah2		mouse	T24	PHOSPHORYLATION	471340	KQPPPPQtPHAPSPA		molecular association, regulation; intracellular localization		EGLN3(INDUCES)		9114	1	0	0	plays a role in degradation of endogenous EGLN3 (PHD3).	
CK1E	EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, CK1; Protein kinase, Ser/Thr (non-receptor)	P49674	1454	CSNK1E	22q13.1	human	S405	PHOSPHORYLATION	449794	EVSRIPAsQTSVPFD		enzymatic activity, inhibited				8419; 2331	2	8	3	some subset of these 8 sites	
CDC5L	DNA binding protein; Motility/polarity/chemotaxis; RNA processing; RNA splicing; Spliceosome; Transcription factor	Q99459	988	CDC5L	6p21	human	T438	PHOSPHORYLATION	3210129	PKPVINStPGRTPLR	Myb_Cef		RNA splicing, altered			3309529	1	6	18		
PRC1	Cell cycle regulation; Cytoskeletal protein; Microtubule binding protein; Motility/polarity/chemotaxis	O43663	9055	PRC1	15q26.1	human	T481	PHOSPHORYLATION	483541	RRGLAPNtPGKARKL	MAP65_ASE1		cell cycle regulation; cytoskeletal reorganization			1968301; 12083	4	6	7		
FcRL4	Membrane protein, integral	Q96PJ5	83417	FCRL4	1q21	human	Y493	PHOSPHORYLATION	22730003	DKDVSVVySEVKTQH			signaling pathway regulation			22723938	1	0	0	all 3 sites (Y451, Y463, Y493) inhibits BCR signaling and enhances TLR9 signaling	
DNER	Membrane protein, integral; Receptor, misc.	Q8NFT8	92737	DNER	2q36.3	human	Y721	PHOSPHORYLATION	473325	SPIAYEDySPDDKPL		intracellular localization				2831768	1	2	10		
TBC1D1	GTPase activating protein, Rab; Ubiquitin-specific protease	Q60949	57915	Tbc1d1		mouse	T590	PHOSPHORYLATION	1247778	AFRRRANtLSHFPVE		activity, inhibited; phosphorylation				25779409; 1968345	6	7	134	reduces inhibitory effect on TBC1D1 on GLUT4 translocation; p70S6K phosphorylation	
SCN2A	Channel, sodium; Membrane protein, integral; Membrane protein, multi-pass	P04775	24766	Scn2a		rat	S576	PHOSPHORYLATION	2999206	PRRNSRAsLFNFKGR	DUF3451	activity, induced				8665	1	3	1		
PIK3R1	Enzyme, regulatory subunit; KINASE; Kinase, lipid; Motility/polarity/chemotaxis	P23727	282307	PIK3R1		cow	T86	PHOSPHORYLATION	22881800	RKKISPPtPKPRPPR		molecular association, regulation		IRS1(DISRUPTS)		22723930	1	0	0		
TR-beta1	DNA binding protein; Nuclear receptor	P10828	7068	THRB	3p24.2	human	S142	PHOSPHORYLATION	449635	IQKNLHPsYSCKYEG	zf-C4	molecular association, regulation	transcription, altered	SMRT(DISRUPTS); p300(INDUCES)		2264	1	0	0		
EFHD2	Unknown function	Q96C19	79180	EFHD2	1p36.21	human	S183	PHOSPHORYLATION	28761200	RLSEIDVsSEGVKGA			cytoskeletal reorganization			28722115	1	1	0	cofilin-induced actin depolymerization, modulates cofilin distribution to the leading edges of lamellipodia induced by EGF, regulation of lamellipodia dynamics	
FOXO1A	DNA binding protein; Nuclear receptor co-regulator; Transcription factor	Q12778	2308	FOXO1	13q14.1	human	K248	ACETYLATION	459031	PEGGKSGkSPRRRAA	Fork_head	intracellular localization; phosphorylation				15022750	5	0	0		
DDEF1	GTPase activating protein, ARF; Motility/polarity/chemotaxis	Q9QWY8	13196	Asap1		mouse	Y782	PHOSPHORYLATION	450438	RDKQRLSyGAFTNQI		molecular association, regulation; activity, inhibited			Other(DISRUPTS)	8222; 2996	2	0	0	modulates DDEF1 phospholipid binding as well as ARF1 GTPase activity; leads to less binding to phospholipids (including P(4,5)P2, PI(3,4,5)P3, and PI(3,4)P2) and less GAP activity toward Arf1	
PKCD	EC 2.7.10.2; EC 2.7.11.13; KINASE; Kinase, protein; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor)	P09215	170538	Prkcd		rat	Y523	PHOSPHORYLATION	450231	EILQGLKySFSVDWW	Pkinase	enzymatic activity, induced				1244	2	0	0		
STIM1	Calcium-binding protein; Endoplasmic reticulum; Membrane protein, integral	P70302	20866	Stim1		mouse	S621	PHOSPHORYLATION	3635048	SHSLSPSsPDPDTPS		molecular association, regulation; protein conformation		ORAI1(INDUCES); EB1(INDUCES)		28100400; 28023923	3	4	1	calcium mobilization and EB1-dependent STIM1 multimerization ; regulate store operated calcium entry (SOCE)	
TH	Amino Acid Metabolism - tyrosine; EC 1.14.16.2; Endoplasmic reticulum; Mitochondrial; Oxidoreductase; Vesicle protein	P04177	25085	Th		rat	S8	PHOSPHORYLATION	448543	MPTPSAPsPQPKGFR	TOH_N	protein stabilization				4592	4	0	0	Phosphorylation of S8  S19 and S31 (more stable) may stabilize TH already phosphorylated at S40 (least stable).	
NMDAR1	Channel, calcium; Channel, ligand-gated; Membrane protein, integral; Membrane protein, multi-pass	Q05586	2902	GRIN1	9q34.3	human	Y837	PHOSPHORYLATION	17613300	LIFIEIAyKRHKDAR	CaM_bdg_C0	molecular association, regulation		CSK(INDUCES)		17431541	1	0	0	Y837F mutation prevents the CSK-induced down-regulation of NMDAR1 activity	
HP1 alpha	Transcription, coactivator/corepressor	Q61686	12419	Cbx5		mouse	S14	PHOSPHORYLATION	476165	RTADSSSsEDEEEYV		molecular association, regulation		H3(INDUCES)	DNA(INDUCES)	18021019	1	23	3	important for chromosomal stability	
polycystin 1	Cell adhesion; Membrane protein, integral; Membrane protein, multi-pass	P98161	5310	PKD1	16p13.3	human	S4252	PHOSPHORYLATION	466929	SLQGRRSsRAPAGSS			cell differentiation, altered			2858607	2	0	0		
IRF3	DNA binding protein; Transcription factor	Q14653	3661	IRF3	19q13.3-q13.4	human	S402	PHOSPHORYLATION	449030	ISNSHPLsLTSDQYK		activity, induced; intracellular localization	transcription, altered			2062; 6337817; 2195490	5	2	0		
MafB	DNA binding protein; Transcription factor	P54841	16658	Mafb		mouse	T62	PHOSPHORYLATION	11555107	VSSTPLStPCSSVPS		protein degradation				11424226	1	0	0		
GTF2I	DNA binding protein; Transcription, coactivator/corepressor	P78347	2969	GTF2I	7q11.23	human	S412	PHOSPHORYLATION	457074	GIPFRRPsTYGIPRL	GTF2I		transcription, induced			8844	2	3	131		
LATS1	EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor)	O95835	9113	LATS1	6q25.1	human	S464	PHOSPHORYLATION	451855	NIPVRSNsFNNPLGN		protein degradation				12525206	1	22	9		
Abl	EC 2.7.1.112; EC 2.7.10.2; KINASE; Kinase, protein; Protein kinase, TK; Protein kinase, tyrosine (non-receptor)	P00519	25	ABL1	9q34.1	human	Y70	PHOSPHORYLATION	462900	PNLFVALyDFVASGD	SH3_1	activity, induced; molecular association, regulation; enzymatic activity, induced		Abi-1(DISRUPTS)		8278; 7483319	2	0	12	Y70 phosphorylation blocks Abl SH3 binding to Abi-1 regulatory protein.  ; required for Bcr-Abl transforming activity	
SNAPIN	Vesicle protein	O95295	23557	SNAPIN	1q21.3	human	S50	PHOSPHORYLATION	448453	HVHAVREsQVELREQ	IncA; Spc7; DivIC; Laminin_II; Flagellar_rod	molecular association, regulation		RAPGEF4(INDUCES); TMEM27(INDUCES); VAMP2(INDUCES); SNAP-25(INDUCES)		18668004	4	0	0		
SHP-2	EC 3.1.3.48; Motility/polarity/chemotaxis; PHOSPHATASE; Protein phosphatase, tyrosine (non-receptor)	P35235	19247	Ptpn11		mouse	Y546	PHOSPHORYLATION	448492	SKRKGHEyTNIKYSL	DUF1092	molecular association, regulation; enzymatic activity, induced	cell adhesion, altered	calnexin(INDUCES); vinculin(INDUCES); GRP78(INDUCES); IP3R1(INDUCES); Grb2(INDUCES)		5917; 3502; 2519600	22	13	386	Ca(2+) release	
H2AX	DNA binding protein; Helicase	P16104	3014	H2AFX	11q23.3	human	Y143	PHOSPHORYLATION	3397700	ATQASQEy_______		molecular association, regulation	apoptosis, induced; DNA repair, altered	Fe65(INDUCES); JNK1(INDUCES)		17613003; 9401438	4	2	1	focus formation and homologous recombination; S143 phosphorylation regulates apoptosis and DNA repair after DNA damage.	
AS160	GTPase activating protein, Rab	Q8BYJ6	210789	Tbc1d4		mouse	S324	PHOSPHORYLATION	455925	EFRSRCSsVTGVMQK	PID	phosphorylation				11390405	9	5	316	TBC1D4 S318/S588/T642/S751A mutation decreases phosphorylation of S711	
ER-alpha	DNA binding protein; Nuclear receptor	P03372	2099	ESR1	6q25.1	human	S559	PHOSPHORYLATION	6048400	PTSRGGAsVEETDQS	ESR1_C	activity, inhibited	transcription, altered			12021304	4	1	0	inhibits ligand-independent activation of ER-alpha	
Rap1GAP	GTPase activating protein, Ras; Motility/polarity/chemotaxis	P47736	5909	RAP1GAP	1p36.1-p35	human	S441	PHOSPHORYLATION	1210678	VIRSRSQsMDAMGLS		activity, induced				6804215	1	7	72	increased Rap1 activity	
GluR6	Channel, calcium; Channel, ligand-gated; Membrane protein, integral; Membrane protein, multi-pass	P39087	14806	Grik2		mouse	S846	PHOSPHORYLATION	11496000	VGEFLYKsKKNAQLE		intracellular localization	endocytosis, altered			11419353	3	0	0		
LHR	GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR	P16235	25477	Lhcgr		rat	S661	PHOSPHORYLATION	451062	LYRRKEFsAYTSNCK		receptor internalization, altered				3286	1	0	0	S661 is required for agonist-induced uncoupling and internalization.  	
ERK5	EC 2.7.11.24; KINASE; Kinase, protein; Protein kinase, CMGC; Protein kinase, Ser/Thr (non-receptor)	Q13164	5598	MAPK7	17p11.2	human	S567	PHOSPHORYLATION	20572700	VLSDNDRsLLERWTR	U79_P34	intracellular localization; enzymatic activity, inhibited	transcription, altered			19084403	1	2	0		
p53	Activator protein; DNA binding protein; Motility/polarity/chemotaxis; Nuclear receptor co-regulator; Transcription factor; Tumor suppressor	P04637	7157	TP53	17p13.1	human	S269	PHOSPHORYLATION	17677100	GNLLGRNsFEVRVCA	P53	protein stabilization; ubiquitination; intracellular localization; protein conformation; activity, inhibited	apoptosis, altered; transcription, inhibited; transcription, altered; cell growth, altered	HSP70(INDUCES)	DNA(DISRUPTS)	17613014; 18378517; 17613011	3	1	0		
IGF1R	EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Protein kinase, TK; Protein kinase, tyrosine (receptor)	P08069	3480	IGF1R	15q26.3	human	Y1281	PHOSPHORYLATION	450102	FREVSFYySEENKLP			apoptosis, altered; cell differentiation, altered; cell growth, altered			2703; 2706	5	0	0		
PTHR	GPCR, family 2; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR	P25961	56813	Pth1r		rat	S504	PHOSPHORYLATION	2853101	GPMVSHTsVTNVGPR		receptor internalization, altered; activity, inhibited				8759; 2831777	2	0	0		
LKB1	Autophagy; EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, CAMK; Protein kinase, Ser/Thr (non-receptor)	Q15831	6794	STK11	19p13.3	human	T185	PHOSPHORYLATION	11454701	KPGNLLLtTGGTLKI	Pkinase	enzymatic activity, induced				10296905	1	0	0	STRAD increases LKB1 activation 	
HDAC1	EC 3.5.1.98; Hydrolase; Nuclear receptor co-regulator	Q13547	3065	HDAC1	1p34	human	S421	PHOSPHORYLATION	447912	IACEEEFsDSEEEGE	SDA1	molecular association, regulation; enzymatic activity, induced		SIN3A(INDUCES)		1395	1	38	36		
MAF1	Transcription regulation	Q9H063	84232	MAF1	8q24.3	human	S60	PHOSPHORYLATION	3211917	PHVLEALsPPQTSGL	Maf1	activity, inhibited	transcription, induced			12778829; 14780536	2	6	0		
TRPC4	Channel, calcium; Membrane protein, integral; Membrane protein, multi-pass	Q9UBN4	7223	TRPC4	13q13.3	human	Y959	PHOSPHORYLATION	456713	EEDSSIDyDLNLPDT		activity, induced; intracellular localization		NHERF(INDUCES)		6875	2	0	0		
PLA2G6	EC 3.1.1.4; Lipid Metabolism - alpha-linolenic acid; Lipid Metabolism - arachidonic acid; Lipid Metabolism - ether lipid; Lipid Metabolism - glycerophospholipid; Lipid Metabolism - linoleic acid; Phospholipase	P97570	360426	Pla2g6		rat	Y672	PHOSPHORYLATION	15512800	AMTEIHEyNQDMIRK		molecular association, regulation		calnexin(INDUCES)		15235224	1	1	0	enzymatic activity of PLA2G6 increases upon incubation with calnexin	
APC	Motility/polarity/chemotaxis; Tumor suppressor	P25054	324	APC	5q21-q22	human	S1501	PHOSPHORYLATION	999605	ESTPDGFsCSSSLSA	APC_crr	phosphorylation				970021	1	0	0	phosphorylation by GSK3 primes for S1504 and S1507 phosphorylation by CK1	
PLB	Inhibitor protein; Membrane protein, integral	P61014	18821	Pln		mouse	T17	PHOSPHORYLATION	448115	SAIRRAStIEMPQQA	Phospholamban; BatA	activity, induced				4125; 5121513	42	6	53	regulates myocyte contraction and relaxation.; increase in calcium spark frequency and size	
ELK1	DNA binding protein; Transcription factor	P41969	13712	Elk1		mouse	S384	PHOSPHORYLATION	447872	IHFWSTLsPIAPRSP		intracellular localization	cell differentiation, altered; transcription, induced; cytoskeletal reorganization; transcription, altered; cell growth, altered		DNA(INDUCES)	4317100; 3427700; 2278	34	1	0		
KHS2	EC 2.7.1.37; EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, STE; Protein kinase, Ser/Thr (non-receptor)	Q8IVH8	8491	MAP4K3	2p22.1	human	S170	PHOSPHORYLATION	12655400	ATIAKRKsFIGTPYW	Pkinase	enzymatic activity, induced				12655101	1	1	3		
ATM	EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, ATYPICAL; Protein kinase, Ser/Thr (non-receptor)	Q13315	472	ATM	11q22-q23	human	S794	PHOSPHORYLATION	6413900	LSNCTKKsPNKIASG		phosphorylation; enzymatic activity, induced	cell cycle regulation; apoptosis, induced			6331315	2	0	0	stimulates phosphorylation of S1981	
LLGL1	Cell adhesion; Cytoskeletal protein; Motility/polarity/chemotaxis	NP_032528	16897	Llgl1		mouse	S672	PHOSPHORYLATION	449918	RIRKSRVsGKKRTPA		intracellular localization				2469	1	1	0		
GABRB1	Channel, chloride; Channel, ligand-gated; Membrane protein, integral; Membrane protein, multi-pass	P50571	14400	Gabrb1		mouse	S434	PHOSPHORYLATION	450244	GRIRRRAsQLKVKIP	Neur_chan_memb	receptor desensitization, altered				2951	6	0	0	GABRB3 S432 demonstrated to play no noticeable role in the desensitization via PKA.	
radixin	Cytoskeletal protein; Motility/polarity/chemotaxis	P26043	19684	Rdx		mouse	T564	PHOSPHORYLATION	448374	AGRDKYKtLRQIRQG	ERM	molecular association, regulation	cell motility, altered; cytoskeletal reorganization	radixin(INDUCES)		12066002; 12068406; 2385	14	2	15	iincreased filopodia with phosphorylated ERM proteins; membrane protrusion	
p53	Activator protein; DNA binding protein; Motility/polarity/chemotaxis; Nuclear receptor co-regulator; Transcription factor; Tumor suppressor	P04637	7157	TP53	17p13.1	human	K381	ACETYLATION	458983	GQSTSRHkKLMFKTE			apoptosis, induced; transcription, altered			2790309; 7647800	19	4	0	 ; ZNF420 (Apak) represses p53 activity by attenuating its acetylation ;  p53 8KR mutant can be still degraded by Mdm2; p53 8KR mutation (K120/164/370/372/373/381/382/386R) impairs p53-dependent transcription	
PXN	Adaptor/scaffold; Cell adhesion; Cytoskeletal protein; Motility/polarity/chemotaxis	Q8VI36	19303	Pxn		mouse	T572	PHOSPHORYLATION	465506	LKQLNKGtFKEQNDK	LIM		cytoskeletal reorganization; cell adhesion, altered			14058629	1	1	0	leads to depolymerization of the actin cytoskeleton and activation of LFA-1 integrins	
BAD	Apoptosis	O35147	64639	Bad		rat	S137	PHOSPHORYLATION	447862	PFRGRSRsAPPNLWA	Bcl-2_BAD; Bclx_interact	activity, induced; molecular association, regulation	apoptosis, altered; apoptosis, inhibited	14-3-3 beta(INDUCES); 14-3-3 zeta(INDUCES); Bcl-xL(DISRUPTS)		7644606; 5915; 6430; 5283	112	26	189		
ACF	Hydrolase; RNA binding protein; RNA processing	Q923K9	170912	A1cf		rat	S154	PHOSPHORYLATION	473053	KKREEILsEMKKVTE	RRM_1	activity, induced				9151	1	0	0	enhances ApoB mRNA editing	
SPTA1	Cytoskeletal protein; Motility/polarity/chemotaxis	P02549	6708	SPTA1	1q21	human	Y1499	PHOSPHORYLATION	6211807	ERTKLGDyANLKQFY			cytoskeletal reorganization			13359104	1	1	0		
TACC3	Cell cycle regulation	Q9JJ11	21335	Tacc3		mouse	S347	PHOSPHORYLATION	474537	ESAWRKQsLYVKFDP		intracellular localization	cell cycle regulation			18410812	6	5	24		
BMAL1	DNA binding protein; Transcription factor	O00327	406	ARNTL	11p15	human	T21	PHOSPHORYLATION	12575204	DFMSPGPtDLLSSSL		protein degradation	transcription, altered			12525210	1	0	0	stabilization of BMAL1 protein leads to reduction in its transcription activation ability	
KIF2C	Cancer Testis Antigen (CTA); Microtubule binding protein; Motility/polarity/chemotaxis; Motor protein	Q99661	11004	KIF2C	1p34.1	human	S111	PHOSPHORYLATION	25159900	KESLRSRsTRMSTVS		molecular association, regulation; intracellular localization; activity, inhibited	cytoskeletal reorganization	EB1(DISRUPTS)		9985931; 27132439; 3306	3	0	6	involved in microtubule tip tracking 	
Chk1	EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, CAMK; Protein kinase, Ser/Thr (non-receptor)	O14757	1111	CHEK1	11q24.2	human	S301	PHOSPHORYLATION	465528	IQSNLDFsPVNSASS		intracellular localization	cell cycle regulation			5358618	5	9	1	 ; mitotic phosphorylation;  important for Chk1 translocation from the nucleus to the cytoplasm when S317 and S345 are dephosphorylated	
DVL2	Adaptor/scaffold; Motility/polarity/chemotaxis	O14641	1856	DVL2	17p13.1	human	S594	PHOSPHORYLATION	22682201	EGSRSSGsTRSDGGA	Dsh_C		cytoskeletal reorganization; transcription, inhibited			27619331	1	0	0	neurite outgrowth	
FGFR1	EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Protein kinase, TK; Protein kinase, tyrosine (receptor)	P11362	2260	FGFR1	8p12	human	Y730	PHOSPHORYLATION	448642	SNCTNELyMMMRDCW	Pkinase_Tyr		cell cycle regulation; transcription, altered			1837	5	1	1	Phosphorylation of either Y463 or Y730, dispensable for mitogenic signaling, represents an absolute requirement for FGF2-mediated uPA induction	
ZAP70	EC 2.7.10.2; KINASE; Kinase, protein; Protein kinase, TK; Protein kinase, tyrosine (non-receptor)	P43403	7535	ZAP70	2q12	human	S520	PHOSPHORYLATION	2861415	FRKFSSRsDVWSYGV	Pkinase_Tyr	intracellular localization; phosphorylation	transcription, altered			2852665	1	0	1	increases autophosphorylation	
HSPB8		Q9UJY1	26353	HSPB8	12q24.23	human	T87	PHOSPHORYLATION	467970	GVPAEGRtPPPFPGE		protein conformation				18898712	2	10	0	increase chaperone activity	
BRAF	EC 2.7.1.37; EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, Ser/Thr (non-receptor); Protein kinase, TKL	P15056	673	BRAF	7q34	human	S579	PHOSPHORYLATION	456814	IIHRDLKsNNIFLHE	Pkinase_Tyr	enzymatic activity, induced				6878	1	0	0	 mutation of T481 is less profound of an effect.  B-Raf S579 shows similar effects to Raf1 S471.; Mutation of Raf1 S471 abolishes kinase activity and EGF-induced activity	
ERK1	EC 2.7.1.123; EC 2.7.11.24; KINASE; Kinase, protein; Protein kinase, CMGC; Protein kinase, Ser/Thr (non-receptor)	Q63844	26417	Mapk3		mouse	Y205	PHOSPHORYLATION	447543	HTGFLTEyVATRWYR	Pkinase; YukC	enzymatic activity, induced	transcription, altered			5766; 5209; 6759; 5354414; 6947; 5691; 4862602	1014	73	3510		
DBI	Lipid binding protein	Q8WN94	100008823	DBI		rabbit	T42	PHOSPHORYLATION	2833500	ATVGDVNtERPGMLD	ACBP	molecular association, regulation		GABRA1(INDUCES)		2831770	1	0	0		
FEN1	DNA binding protein; DNA repair; Deoxyribonuclease; EC 3.1.-.-; Ribonuclease	P39748	2237	FEN1	11q12	human	K354	UBIQUITINATION	15388693	TGSLSSAkRKEPEPK		protein degradation; ubiquitination				25712619	1	1	1		
PKR	EC 2.7.10.2; EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor); Translation	P19525	5610	EIF2AK2	2p22-p21	human	T446	PHOSPHORYLATION	448088	LKNDGKRtRSKGTLR	Pkinase	enzymatic activity, induced	cell cycle regulation; cell growth, altered			6542; 6146; 754	6	1	0		
BRAF	EC 2.7.1.37; EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, Ser/Thr (non-receptor); Protein kinase, TKL	P15056	673	BRAF	7q34	human	S729	PHOSPHORYLATION	450242	PKIHRSAsEPSLNRA		molecular association, regulation; enzymatic activity, induced	cell differentiation, altered; cell growth, altered	14-3-3 beta(INDUCES); RAF1(INDUCES)		8349; 12025500	4	26	25		
K18	Cytoskeletal protein	P05783	3875	KRT18	12q13	human	S51	PHOSPHORYLATION	3179064	SRISVSRsTSFRGGM		intracellular localization	cytoskeletal reorganization			27902307	1	2	9	keratin filament buckling, S51-p is localized in the periphery of the cell.	
perilipin	Lipid binding protein	Q8CGN5	103968	Plin1		mouse	S222	PHOSPHORYLATION	450080	PSLVRRVsTLANTLS	Perilipin	molecular association, regulation		HSL(INDUCES)		11424203	2	3	4		
DRD1	GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR	P21728	1812	DRD1	5q35.1	human	T360	PHOSPHORYLATION	449796	ATNNAIEtVSINNNG		receptor desensitization, altered; receptor internalization, altered				1056	1	0	0		
NCAM-L1	Cell adhesion; Membrane protein, integral	P32004	3897	L1CAM	Xq28	human	S1152	PHOSPHORYLATION	449315	RSKGGKYsVKDKEDT	Bravo_FIGEY		cytoskeletal reorganization			9177; 2179	2	0	0		
Net1	Guanine nucleotide exchange factor, Rac/Rho; Motility/polarity/chemotaxis	Q9Z206	56349	Net1		mouse	S153	PHOSPHORYLATION	455601	TPTKRRSsALWSEML		activity, inhibited	cytoskeletal reorganization			5530	1	0	0	inhibits guanine nucleotide exhange activity toward RhoA, inhibits actin stress fiber formation	
CDK10	EC 2.7.11.22; KINASE; Kinase, protein; Protein kinase, CMGC; Protein kinase, Ser/Thr (non-receptor)	Q15131	8558	CDK10	16q24	human	T133	PHOSPHORYLATION	27422500	SLLENMPtPFSEAQV	Pkinase	molecular association, regulation		Pin1(INDUCES)		25185213	1	0	0		
THOP1	EC 3.4.24.15; Protease	P24155	64517	Thop1		rat	S644	PHOSPHORYLATION	448213	VGMDYRTsILRPGGS	Peptidase_M3	molecular association, regulation; intracellular localization; enzymatic activity, induced		14-3-3 epsilon(INDUCES)		5501; 1072	2	1	0		
TAZ	Transcription, coactivator/corepressor	Q9GZV5	25937	WWTR1	3q23-q24	human	S89	PHOSPHORYLATION	457660	AQHVRSHsSPASLQL		intracellular localization	carcinogenesis, inhibited; transcription, inhibited; transcription, altered			15031345; 22631800	5	6	73	cytoplasmic localization; constitutive active mutant TAZ S89A 	
NR2C1	DNA binding protein; Nuclear receptor	Q505F1	22025	Nr2c1		mouse	S568	PHOSPHORYLATION	456552	IGNVRIDsVIPHILK		protein stabilization	transcription, altered			6693	1	0	0		
MAIR-I	Immunoglobulin superfamily; Membrane protein, integral	Q7TSN3	217303	Cd300a		mouse	Y274	PHOSPHORYLATION	455227	LPQEELHySSVAFNS	Cytadhesin_P30	molecular association, regulation		SHIP(INDUCES); SHP-2(INDUCES); SHP-1(INDUCES)		4443	1	0	6		
ACTN4	Cytoskeletal protein; Motility/polarity/chemotaxis	O43707	81	ACTN4	19q13	human	Y265	PHOSPHORYLATION	450725	MTYVSSFyHAFSGAQ	CH	molecular association, regulation; protein processing; intracellular localization; protein conformation	cytoskeletal reorganization	ACTA1(INDUCES)		27623406; 11419364	2	13	504	required for dorsal stress fiber establishment, transverse arc maintenance, and focal adhesion maturation; F-actin binding	
Rb	Nuclear receptor co-regulator; Transcription, coactivator/corepressor; Tumor suppressor	P06400	5925	RB1	13q14.2	human	S612	PHOSPHORYLATION	447977	MYLSPVRsPKKKGST		molecular association, regulation; protein conformation	apoptosis, induced; transcription, altered	E2F1(DISRUPTS); E2F1(INDUCES)		14146309; 777; 9601	8	8	33		
coronin 1A	Cytoskeletal protein; Motility/polarity/chemotaxis	O89053	12721	Coro1a		mouse	T418	PHOSPHORYLATION	4701031	DSARRRAtPEPSGTP	DUF1465; AKNA		cell motility, altered; cytoskeletal reorganization			15785201	1	10	3		
IRAK1	EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, Ser/Thr (non-receptor); Protein kinase, TKL	Q62406	16179	Irak1		mouse	T66	PHOSPHORYLATION	447722	CERSEQRtASVLWPW	RAMP; Death	molecular association, regulation; enzymatic activity, induced	transcription, altered	PKCI(INDUCES)		8583	3	0	0	autophosphorylation activity	
TRHR	GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR	Q01717	25570	Trhr		rat	S355	PHOSPHORYLATION	1229702	YSVALNYsVIKESDR		receptor internalization, altered				1172827; 14551416	3	0	0		
Huntingtin	Cytoskeletal protein	P42858	3064	HTT	4p16.3	human	S419	PHOSPHORYLATION	448106	GGRSRSGsIVELIAG		activity, induced; molecular association, regulation	apoptosis, inhibited; cytoskeletal reorganization	KIF5B(INDUCES); dynactin 1(INDUCES)		4324803; 6782003; 3083; 1694; 1926903	6	15	17	vesicular transport of BDNF in axons; S421A causes more Huntington's disease-like lesions in the 68Q huntingtin expressing rats.	
Bub1	Cell cycle regulation; EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor)	O43683	699	BUB1	2q14	human	S314	PHOSPHORYLATION	481705	SHEDLPAsQERSEVN		enzymatic activity, induced	cell cycle regulation			22463922	2	2	0	required for the spindle checkpoint activation	
PKCI	Cell adhesion; Cell development/differentiation; EC 2.7.11.13; EC 3.-.-.-; KINASE; Kinase, protein; Motility/polarity/chemotaxis; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor)	P41743	5584	PRKCI	3q26.3	human	T412	PHOSPHORYLATION	454434	RPGDTTStFCGTPNY	Pkinase	enzymatic activity, induced				4732	6	12	26		
Bcl-xL	Apoptosis; Autophagy; Membrane protein, integral; Mitochondrial	Q07817	598	BCL2L1	20q11.21	human	S49	PHOSPHORYLATION	21336504	ESEMETPsAINGNPS			cell cycle regulation			21126712	1	0	0	stabilizes G2 arrest;  enables cytokinesis and mitotic exit	
SLC22A1	Membrane protein, integral; Membrane protein, multi-pass; Transporter	Q63089	24904	Slc22a1		rat	S292	PHOSPHORYLATION	455611	ESPRWLLsQKRTTRA	Sugar_tr	activity, induced				5524	1	0	0	stimulates ASP+ uptake	
14-3-3 zeta	Adaptor/scaffold; Motility/polarity/chemotaxis	P63101	22631	Ywhaz		mouse	Y179	PHOSPHORYLATION	7316700	LNFSVFYyEILNSPE	14-3-3; CIA30; TPR_12	molecular association, regulation; phosphorylation		Shc1(INDUCES)		6804209	1	1	0	important for the phosphorylation of Akt and cytokine-mediated cell survival 	
UBF	DNA binding protein; Transcription factor	P25977	25574	Ubtf		rat	T117	PHOSPHORYLATION	448504	DFPKKPLtPYFRFFM	HMG_box		transcription, inhibited			1393	1	1	13		
NUP98 iso2	Motility/polarity/chemotaxis; Nucleoporin	P52948-2	4928	NUP98	11p15.5	human	S861	PHOSPHORYLATION	18330804	GSWVFKVsHFSKYGL	Nucleoporin2	intracellular localization				18331300	1	1	0	as multiple sites (13PM) mutant 	
IL4R	Membrane protein, integral; Receptor, cytokine	P16382	16190	Il4r		mouse	Y500	PHOSPHORYLATION	451065	VLADNPAyRSFSDCC		activity, induced; phosphorylation	cell cycle regulation			5652; 6961	3	0	0	Akt and p70S6K phosphorylation	
Cdc34	EC 6.3.2.19; Ligase; UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase	P49427	997	CDC34	19p13.3	human	S236	PHOSPHORYLATION	448690	DDSGTEEs_______		intracellular localization				1868	2	0	0		
CREB	DNA binding protein; Transcription factor	P16220	1385	CREB1	2q34	human	T100	PHOSPHORYLATION	457131	LKRLFSGtQISTIAE		activity, inhibited; phosphorylation	transcription, inhibited			9565; 7037	3	0	0		
PKLR iso2	Carbohydrate Metabolism - glycolysis and gluconeogenesis; Carbohydrate Metabolism - pyruvate; EC 2.7.1.40; Kinase, other; Nucleotide Metabolism - purine	P30613-2	5313	PKLR	1q21	human	S12	PHOSPHORYLATION	1218250	AGYLRRAsVAQLTQE		protein conformation				27579000	3	0	6	 energetic coupling of S12 phosphorylation and oxidation of Cys 436 to phosphoethanolamine binding	
IRAK4	EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, Ser/Thr (non-receptor); Protein kinase, TKL	Q9NWZ3	51135	IRAK4	12q12	human	T342	PHOSPHORYLATION	2045344	ASEKFAQtVMTSRIV	Pkinase	enzymatic activity, induced				25785409; 2852672	1	2	0		
IkB-alpha	DNA binding protein; Inhibitor protein	P25963	4792	NFKBIA	14q13	human	S32	PHOSPHORYLATION	448203	LLDDRHDsGLDSMKD		activity, induced; protein degradation; intracellular localization; phosphorylation	apoptosis, altered; apoptosis, induced; apoptosis, inhibited; transcription, induced; transcription, altered			6035; 2512006; 2097; 6802; 14746200; 4914008; 4859900; 2181; 7156; 5638; 5900; 4914006; 6273; 6175; 2153; 6934; 1125; 5743; 4914009; 6510; 5674; 666; 4914007; 1737; 6291; 7178	118	1	7		
RPS3	Apoptosis; Ribosomal protein; Translation	P23396	6188	RPS3	11q13.3-q13.5	human	T221	PHOSPHORYLATION	452652	KDEILPTtPISEQKG		activity, induced; intracellular localization	translation, altered			21040948; 8049907	5	53	93	nuclear accumulation; important for a cell survival in the stress condition	
BLNK	Adaptor/scaffold	Q8WV28	29760	BLNK	10q23.2-q23.33	human	Y189	PHOSPHORYLATION	447717	VEDNDENyIHPTESS		molecular association, regulation	transcription, altered	Nck2(INDUCES); PLCG1(INDUCES); Btk(INDUCES); VAV1(INDUCES)		7669	1	1	4	Sites mutated alone and in combination (Y189,Y178and Y96) prevented binding of PLCG1 and mobization of Ca2+. For NF-AT transcriptional activity Y103,Y194 and Y205 residues were necessary.Tyrosine phosphoryation of BLNK induces MAPK activation. 



; Sites mutated alone and in combination (Y189,Y178and Y96) prevented binding of PLCG1 and mobization of Ca2+. For NF-AT transcriptional activity Y103,Y194 and Y205 residues were necessary.Tyrosine phosphoryation of BLNK induces MAPK activation. 

	
PLK4	EC 2.7.11.21; KINASE; Kinase, protein; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor)	Q64702	20873	Plk4		mouse	T293	PHOSPHORYLATION	12654011	GHATLSTtITASSGT		protein degradation; ubiquitination				12525201	1	1	0		
restin	Cytoskeletal protein	P30622	6249	CLIP1	12q24.3	human	S195	PHOSPHORYLATION	468616	LTKTASEsISNLSEA		intracellular localization; phosphorylation				15022731	2	27	34	enhances phosphorylation of S1353	
NR4A2	DNA binding protein; Nuclear receptor	P43354	4929	NR4A2	2q22-q23	human	S126	PHOSPHORYLATION	487424	SVYYKPSsPPTPTTP			transcription, induced			12244	2	0	0		
PAK1	EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, STE; Protein kinase, Ser/Thr (non-receptor)	P35465	29431	Pak1		rat	T422	PHOSPHORYLATION	448177	PEQSKRStMVGTPYW	Pkinase	enzymatic activity, induced				738	24	2	9		
Scribble iso3	Cell adhesion; Motility/polarity/chemotaxis	Q80U72-3	105782	Scrib		mouse	S1601	PHOSPHORYLATION	449228	RPVYDIQsPDFVEEL		molecular association, regulation; intracellular localization	cell adhesion, altered	CDH1(DISRUPTS)		17675065	1	22	6	interaction with E-cadherin-catenin complex	
IkB-alpha	DNA binding protein; Inhibitor protein	Q9Z1E3	18035	Nfkbia		mouse	S293	PHOSPHORYLATION	451525	EESYDTEsEFTEDEL		protein degradation				3761	3	0	0	S293 phosphorylation is required for rapid proteolysis of the unassociated protein.	
FOXO3A	Autophagy; DNA binding protein; Transcription factor	O43524	2309	FOXO3	6q21	human	S644	PHOSPHORYLATION	451438	GLDFNFDsLISTQNV		protein degradation; intracellular localization; activity, inhibited	cell cycle regulation; apoptosis, inhibited; transcription, inhibited			3644; 30280006	2	0	0	nuclear to cytoplasm transport, repressed FOXO3A-induced p27 promoter activity	
GRF-1	GTPase activating protein, Rac/Rho; Motility/polarity/chemotaxis; Transcription factor	Q91YM2	232906	Grlf1		mouse	Y308	PHOSPHORYLATION	455312	ASPEYQDyVYLEGTQ		molecular association, regulation		GTF2I(DISRUPTS)		4497	1	0	0		
USF1	DNA binding protein; Transcription factor	Q61069	22278	Usf1		mouse	S262	PHOSPHORYLATION	7367003	RQSNHRLsEELQGLD		molecular association, regulation; acetylation	transcription, altered	SREBP-1(INDUCES)		7303912	2	1	0		
Kv1.3	Channel, potassium; Membrane protein, integral; Membrane protein, multi-pass	P22001	3738	KCNA3	1p13.3	human	Y187	PHOSPHORYLATION	451293	FSEEIRFyQLGEEAM	K_tetra	activity, induced				3518	1	0	0		
DNAPK	DNA repair; EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, ATYPICAL; Protein kinase, Ser/Thr (non-receptor)	P78527	5591	PRKDC	8q11	human	T2638	PHOSPHORYLATION	448712	VAGQIRAtQQQHDFT			chromatin organization, altered; cell growth, altered			9570	4	8	8	increases survival in ionizing radiation and repairing double strand DNA breaks	
P38A	EC 2.7.1.37; EC 2.7.11.24; KINASE; Kinase, protein; Protein kinase, CMGC; Protein kinase, Ser/Thr (non-receptor)	P70618	81649	Mapk14		rat	Y182	PHOSPHORYLATION	447971	TDDEMTGyVATRWYR	Pkinase	enzymatic activity, induced	cell growth, altered			7472	310	68	3676		
FOXO4	DNA binding protein; Transcription factor	Q9WVH3	54601	Foxo4		mouse	S197	PHOSPHORYLATION	448516	APRRRAAsMDSSSKL	Fork_head	molecular association, regulation	transcription, altered	14-3-3 zeta(INDUCES)		5458	12	1	5		
Rb	Nuclear receptor co-regulator; Transcription, coactivator/corepressor; Tumor suppressor	P13405	19645	Rb1		mouse	T350	PHOSPHORYLATION	447981	DSFETERtPRKNNPD		molecular association, regulation		E2F1(DISRUPTS)		1258	6	8	28		
RalA	G protein; G protein, monomeric, Ras; Membrane protein, anchored; Motility/polarity/chemotaxis	P11233	5898	RALA	7p15-p13	human	S194	PHOSPHORYLATION	483989	NGKKKRKsLAKRIRE		molecular association, regulation; intracellular localization	cytoskeletal reorganization; cell growth, altered	RALBP1(NOT_REPORTED)		11999216	3	0	1	localization to plasma membrane	
RNF2	EC 6.3.2.-; EC 6.3.2.19; Ligase; UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase	Q99496	6045	RNF2	1q25.3	human	S41	PHOSPHORYLATION	7670101	DGLEIVVsPRSLHSE			transcription, altered			7659807	0	4	2		
PECAM-1	Cell adhesion; Membrane protein, integral	P16284	5175	PECAM1	17q23.3	human	S700	PHOSPHORYLATION	455609	VQVSSAEsHKDLGKK		molecular association, regulation		desmoplakin 3(DISRUPTS)		5498	0	0	2		
SLC14A2	Membrane protein, integral; Membrane protein, multi-pass; Transporter	NP_062220	54302	Slc14a2		rat	T524	PHOSPHORYLATION	2813502	PYLYRKPtVELLDLN		activity, induced				2807221	1	0	0		
POLH	DNA repair; EC 2.7.7.7; Transferase	Q9Y253	5429	POLH	6p21.1	human	S587	PHOSPHORYLATION	5024701	GVSKLEEsSKATPAE	PRP21_like_P	intracellular localization	cell growth, altered			5007913	1	0	0	foci formation efficiency after  DNA damage	
LIG1	DNA repair; EC 6.5.1.1; Ligase	P18858	3978	LIG1	19q13.2-q13.3	human	S66	PHOSPHORYLATION	448498	KAARVLGsEGEEEDE		molecular association, regulation; intracellular localization	cell growth, altered	RFC1(INDUCES); Rad17(DISRUPTS)		7072901; 8424	4	25	7	regulates DNA replication and repair	
MRE11A	Cell cycle regulation; DNA binding protein; DNA repair; Deoxyribonuclease	P49959	4361	MRE11A	11q21	human	S531	PHOSPHORYLATION	5846030	TRARALRsQSEESAS		molecular association, regulation			DNA(DISRUPTS)	11484420	1	0	1		
Etk	EC 2.7.10.2; KINASE; Kinase, protein; Protein kinase, TK; Protein kinase, tyrosine (non-receptor)	P51813	660	BMX	Xp22.2	human	Y40	PHOSPHORYLATION	448066	LTKTNLSyYEYDKMK	PH	molecular association, regulation; intracellular localization; enzymatic activity, induced	cell motility, altered; cytoskeletal reorganization	FAK(INDUCES)		834	3	0	0		
Chk1	EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, CAMK; Protein kinase, Ser/Thr (non-receptor)	O35280	12649	Chek1		mouse	S286	PHOSPHORYLATION	465527	TSGGMSEsSSGFSKH		intracellular localization				11419348	5	5	13		
hnRNP A3	RNA binding protein; RNA splicing; Spliceosome	Q8BG05	229279	Hnrnpa3		mouse	S359	PHOSPHORYLATION	483226	FGGRSSGsPYGGGYG		molecular association, regulation			RNA(DISRUPTS)	15562504	1	41	78		
JPH2	Contractile protein; Endoplasmic reticulum; Membrane protein, integral	Q9ET78	59091	Jph2		mouse	S165	PHOSPHORYLATION	4779179	PLRTSLSsLRSEHSN		molecular association, regulation		TRPC3(INDUCES)		22597799	2	2	1	S165F mutant showes hypertrophy and increased resting cytoplasmic Ca2+ levels.	
REL	Transcription factor	Q04864	5966	REL	2p13-p12	human	S503	PHOSPHORYLATION	453447	VNMMTTSsDSMGETD			apoptosis, inhibited; transcription, induced; transcription, altered			3204; 6616	2	0	0	S503A mutation enhances REL's transforming activity in vitro, while S503D mutation inhibits it.	
TRPV1	Channel, cation; Membrane protein, integral; Membrane protein, multi-pass; Receptor, misc.	O35433	83810	Trpv1		rat	S800	PHOSPHORYLATION	450017	VPLLRDAsTRDRHAT		activity, induced; receptor desensitization, altered				8873; 8871; 25797202; 2725501; 8872; 1172841; 8750	14	0	0	regulate TRPV1 channel activity; contributes to endothelin-induced thermal hyperalgesia; S800 phosphorylation induces VR1 potentiation. 	
IGF1R	EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Protein kinase, TK; Protein kinase, tyrosine (receptor)	Q60751	16001	Igf1r		mouse	Y1163	PHOSPHORYLATION	448386	FGMTRDIyETDYYRK	Pkinase_Tyr	enzymatic activity, induced	cell cycle regulation; cell motility, altered			2500; 2790302	16	19	453		
H3	DNA binding protein	Q6LED0	291159	Hist1h2ail		rat	S11	PHOSPHORYLATION	455676	TKQTARKsTGGKAPR			chromatin organization, altered; cytoskeletal reorganization; transcription, induced			12023002; 12261	167	5	1	correlated with nuclear infolding	
claspin	Actin binding protein; Cell cycle regulation	Q9HAW4	63967	CLSPN	1p34.2	human	S34	PHOSPHORYLATION	467251	PSDSGQGsYETIGPL		protein degradation; molecular association, regulation	cell cycle regulation	BTRC(INDUCES)		8187	1	0	0	claspin degradation is necessary for termination of the DNA replication checkpoint.	
Bcl-xL	Apoptosis; Autophagy; Membrane protein, integral; Mitochondrial	P53563	24888	Bcl2l1		rat	S106	PHOSPHORYLATION	5014911	LRYRRAFsDLTSQLH	Bcl-2	molecular association, regulation	apoptosis, altered	VDAC1(DISRUPTS); Akt1(INDUCES)		5014014	1	0	0		
DOR-1	GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR	P32300	18386	Oprd1		mouse	S344	PHOSPHORYLATION	448552	CGRQEPGsLRRPRQA		receptor desensitization, altered; receptor internalization, altered				1670	1	0	0		
5-HT(1A)	GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR	P19327	24473	Htr1a		rat	T149	PHOSPHORYLATION	467261	IDYVNKRtPRRAAAL	7tm_1	receptor inactivation, altered				8209	2	0	0	uncouples the 5-HT receptor signaling (through G-proteins) from Ca(2+) channel	
SAPAP1	Cytoskeletal protein	O14490	9229	DLGAP1	18p11.31	human	S375	PHOSPHORYLATION	481510	KVAARREsYLKATQP		molecular association, regulation		PSD-95(INDUCES)		25229706	2	0	0	Fluorescence Polarization	
ADCY2	Adenylyl cyclase; EC 4.6.1.1; Lyase; Membrane protein, integral; Membrane protein, multi-pass; Nucleotide Metabolism - purine	P26769	81636	Adcy2		rat	S871	PHOSPHORYLATION	451125	AEHFLARsLKNEELY		activity, induced				3326	1	0	0		
SKAR	RNA binding protein	Q9BY77	84271	POLDIP3	22q13.2	human	S385	PHOSPHORYLATION	454011	PRRVNSAsSSNPPAE		activity, induced		ERH(NOT_REPORTED)		2537401; 4156	1	1	1	phosphorylation of this site is involved in the control of cell growth	
PhLP	G protein regulator, misc.	Q63737	64013	Pdcl		rat	S20	PHOSPHORYLATION	448825	LQYYYSTsEDEDSDH		activity, inhibited				1996	3	4	3		
Bim	Apoptosis	O54918	12125	Bcl2l11		mouse	S65	PHOSPHORYLATION	449330	GPLAPPAsPGPFATR		protein degradation; molecular association, regulation	apoptosis, altered; apoptosis, induced; apoptosis, inhibited	Bax(DISRUPTS)		2915501; 4230; 9090; 2188	18	0	1		
PIK3R1	Enzyme, regulatory subunit; KINASE; Kinase, lipid; Motility/polarity/chemotaxis	P27986	5295	PIK3R1	5q13.1	human	S608	PHOSPHORYLATION	448133	ENTEDQYsLVEDDED		activity, induced				4694	2	1	23		
IGF1R	EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Protein kinase, TK; Protein kinase, tyrosine (receptor)	P08069	3480	IGF1R	15q26.3	human	S1311	PHOSPHORYLATION	2091902	PLDPSASsSSLPLPD		activity, induced; phosphorylation	apoptosis, altered; cell differentiation, altered; cell growth, altered			2703; 2727	2	0	0	observed in Y980F +  S1310-1313A; ERK phosphorylation	
Smad1	DNA binding protein; Transcription factor	Q15797	4086	SMAD1	4q31	human	S462	PHOSPHORYLATION	448361	GSPHNPIsSVS____		activity, induced; molecular association, regulation; intracellular localization	transcription, altered	Smad4(INDUCES)		3385; 785	2	3	4		
Cdc25B	EC 3.1.3.48; Motility/polarity/chemotaxis; Nuclear receptor co-regulator; PHOSPHATASE; Protein phosphatase, dual-specificity	P30305	994	CDC25B	20p13	human	S353	PHOSPHORYLATION	452008	VQNKRRRsVTPPEEQ	M-inducer_phosp		cell cycle regulation			3917; 30280007; 6839	7	5	9		
WAVE2	Actin binding protein; Motility/polarity/chemotaxis	Q9Y6W5	10163	WASF2	1p36.11	human	S351	PHOSPHORYLATION	18715500	PGTPPPPsPPSFPPH		molecular association, regulation	cell motility, altered; cytoskeletal reorganization			18668222	1	0	0	regulates WRC (WAVE2 regulatory complex) interaction with Arp2/3 and lamellipodial protrusion	
ROR2	EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Protein kinase, TK; Protein kinase, tyrosine (receptor)	Q9Z138	26564	Ror2		mouse	S864	PHOSPHORYLATION	20659200	PKPSSHHsGSGSTST			cell motility, induced			19016936	1	0	0		
STAT3	DNA binding protein; Motility/polarity/chemotaxis; Nuclear receptor co-regulator; Transcription factor	P42227	20848	Stat3		mouse	Y705	PHOSPHORYLATION	448192	DPGSAAPyLKTKFIC		activity, induced; molecular association, regulation; ubiquitination; intracellular localization	cell cycle regulation; apoptosis, inhibited; transcription, induced; transcription, altered; cell growth, altered	PDGFRA(INDUCES)	DNA(INDUCES)	5410118; 1929900; 5954; 1965400; 1828; 13789006; 6280; 6912; 6911; 2721; 5704; 6271030	251	36	3028		
BCAP	Adaptor/scaffold	Q9DDT2	374268	PIK3AP1		chicken	Y463	PHOSPHORYLATION	449909	PGAPEDLyVEMLQSK		molecular association, regulation		PIK3R1(INDUCES)		1374	2	0	0		
MCL1	Apoptosis; Channel, misc.; Inhibitor protein; Membrane protein, integral; Mitochondrial	Q07820	4170	MCL1	1q21	human	T92	PHOSPHORYLATION	4825134	EVPDVTAtPARLLFF		protein degradation; protein stabilization; molecular association, regulation	apoptosis, altered; cell growth, altered	Pin1(INDUCES)		14780524; 4646402	3	1	2		
NHE1	Membrane protein, integral; Membrane protein, multi-pass; Motility/polarity/chemotaxis; Transporter	P19634	6548	SLC9A1	1p36.1-p35	human	S648	PHOSPHORYLATION	3880766	KTRQRLRsYNRHTLV	Toprim_3	molecular association, regulation; activity, inhibited		calmodulin(DISRUPTS)		4049507	3	1	6		
Kv4.2	Channel, potassium; Membrane protein, integral; Membrane protein, multi-pass	Q63881		Kcnd2		rat	S459	PHOSPHORYLATION	2906104	LLSNQLQsSEDEPAF	DUF3399	protein stabilization				8602	1	0	0		
ZBTB1	C2H2-type zinc finger protein	Q9Y2K1	22890	ZBTB1	14q23.3	human	K265	SUMOYLATION	2894413	DGKDSNIkAEFGEKD		activity, inhibited	transcription, altered			15510800	1	1	0	reduces transcriptional repressive activity	
LRRC7	Cell adhesion	P70587	117284	Lrrc7		rat	S1392	PHOSPHORYLATION	481330	IQTKGQRsMDGYPEQ		molecular association, regulation		CAMK2A(DISRUPTS)		2852653	1	9	0		
SRC-3	ACETYLTRANSFERASE; Acetyltransferase; EC 2.3.1.48; Motility/polarity/chemotaxis; Nuclear receptor co-regulator; Transcription, coactivator/corepressor	Q9Y6Q9	8202	NCOA3	20q12	human	T1059	PHOSPHORYLATION	4252801	ALLDQLHtLLSNTDA	Nuc_rec_co-act	protein stabilization; molecular association, regulation		PSMA3(DISRUPTS)		4248206	1	0	0	some subset of these 8 residues	
MAX	DNA binding protein; Transcription factor	P52164	60661	Max		rat	S2	PHOSPHORYLATION	449307	______MsDNDDIEV	Filament; ATG16; Myosin_tail_1	molecular association, regulation			DNA(NOT_REPORTED)	2175	4	12	0	increases both the on- and off-rates for DNA binding	
PAG	Adaptor/scaffold; Membrane protein, integral	Q3U1F9	94212	Pag1		mouse	Y314	PHOSPHORYLATION	450659	EEEISAMySSVNKPG		molecular association, regulation		CSK(INDUCES)		9298	8	17	623		
CARM1	EC 2.1.1.-; EC 2.1.1.125; METHYLTRANSFERASE; Methyltransferase; Methyltransferase, protein arginine; Nuclear receptor co-regulator	Q9WVG6	59035	Carm1		mouse	S217	PHOSPHORYLATION	11311202	KIYAVEAsTMAQHAE	PRMT5	intracellular localization; enzymatic activity, inhibited				11189916	1	1	0	reduces cofactor AdoMet binding	
SMRT	Nuclear receptor co-regulator; Transcription, coactivator/corepressor	Q9Y618	9612	NCOR2	12q24	human	S2437	PHOSPHORYLATION	6422852	ASGDRPPsVSSVHSE		protein degradation; ubiquitination; intracellular localization	transcription, induced; signaling pathway regulation			25712628	1	0	0	activates Notch1 signaling in intact cells	
DARPP-32	Motility/polarity/chemotaxis; Protein phosphatase, regulatory subunit	Q6J4I0	360616	Ppp1r1b		rat	T75	PHOSPHORYLATION	448048	RPNPCAYtPPSLKAV	DARPP-32; Drc1-Sld2; SPX; PPP4R2; Nucleoplasmin; Nop14		transcription, altered			4017	26	4	16	Cocaine sensitized rats showed increased phosphorylation at T75 and decreased at T34, as well as increased Cdk5 expression. 	
MDM4	EC 6.3.2.-; Ligase; UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase	O15151	4194	MDM4	1q32	human	S289	PHOSPHORYLATION	456471	DDLEDSKsLSDDTDV	Cript	molecular association, regulation				6701	2	0	0		
axin 1	Adaptor/scaffold	O70239	79257	Axin1		rat	S485	PHOSPHORYLATION	451092	MRTPGCQsPGPGHRS	Axin_b-cat_bind		cytoskeletal reorganization			25797201	2	4	5	Phosphorylation regulates responsive to Sema3A induced growth cone collapse.	
CUL5	Ubiquitin conjugating system	Q93034	8065	CUL5	11q22.3	human	S730	PHOSPHORYLATION	963800	MKMRKKIsNAQLQTE	Cullin_Nedd8	intracellular localization; activity, inhibited; neddylation	cell growth, altered			11419344; 8880	5	0	0	regulates CUL5 neddylation	
FGFR1	EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Protein kinase, TK; Protein kinase, tyrosine (receptor)	P11362	2260	FGFR1	8p12	human	S779	PHOSPHORYLATION	27930809	PLDQYSPsFPDTRSS			cell differentiation, induced; apoptosis, inhibited			27902333	1	0	0	neurite extension	
SQSTM1	Autophagy; Nuclear receptor co-regulator; Ubiquitin conjugating system	Q13501	8878	SQSTM1	5q35	human	S403	PHOSPHORYLATION	22264800	ESLSQMLsMGFSDEG			autophagy, induced			25712652	2	1	0		
TVB5		P04213		TVB5		mouse	S78	PHOSPHORYLATION	25573800	GYKASRPsQENFSLI	V-set	activity, induced				8839	1	0	0	IL-2 secretion in response superantigen staphylococcal enterotoxin B (SEB) binding	
PAK1	EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, STE; Protein kinase, Ser/Thr (non-receptor)	Q13153	5058	PAK1	11q13-q14	human	S199	PHOSPHORYLATION	448172	PRPEHTKsVYTRSVI		intracellular localization; protein conformation; enzymatic activity, induced	cell motility, altered; cell adhesion, altered			9987305	12	0	0	recruitment to the plasma membrane	
GluR6	Channel, calcium; Channel, ligand-gated; Membrane protein, integral; Membrane protein, multi-pass	P39087	14806	Grik2		mouse	S868	PHOSPHORYLATION	478417	MVEELRMsLKCQRRL		intracellular localization				11419353	5	0	0		
emerin	Cytoskeletal protein; Membrane protein, integral	P50402	2010	EMD	Xq28	human	Y4	PHOSPHORYLATION	3071455	____MDNyADLSDTE	LEM	molecular association, regulation		BAF(DISRUPTS)		10425105	1	2	1		
BAD	Apoptosis	Q61337	12015	Bad		mouse	S155	PHOSPHORYLATION	447863	GRELRRMsDEFEGSF	Bcl-2_BAD; Bclx_interact	molecular association, regulation	apoptosis, altered; apoptosis, inhibited	14-3-3 gamma(INDUCES); Bcl-xL(DISRUPTS)		6595; 2347; 3340213; 5325; 6594; 5376; 25255521; 467; 6596; 13320402; 2659; 4478; 2348	43	28	136		
NMDAR2A	Channel, ligand-gated; Membrane protein, integral; Membrane protein, multi-pass	Q12879	2903	GRIN2A	16p13.2	human	Y1325	PHOSPHORYLATION	458211	RLLEGNFyGSLFSVP	NMDAR2_C	activity, induced				11262505	2	0	86		
ezrin	Cytoskeletal protein; Motility/polarity/chemotaxis	P26040	22350	Ezr		mouse	Y146	PHOSPHORYLATION	448758	KEMHKSGyLSSERLI	FERM_M	phosphorylation	cell cycle regulation; apoptosis, inhibited; cell growth, altered			3548304	9	1	0	ERK phosphorylation	
PKG2	EC 2.7.11.12; KINASE; Kinase, protein; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor)	Q61410	19092	Prkg2		mouse	S126	PHOSPHORYLATION	450477	RGAKAGVsAEPTTRT		enzymatic activity, induced				3017	2	1	0		
HSL	EC 3.1.1.79; Lipase	P15304	25330	Lipe		rat	S865	PHOSPHORYLATION	448804	ESMRRSVsEAALAQP		enzymatic activity, induced				2860	17	12	1		
YY1	C2H2-type zinc finger protein; Cell development/differentiation; Transcription factor	P25490	7528	YY1	14q	human	S118	PHOSPHORYLATION	460025	EVVGGDDsDGLRAED		protein stabilization				22723915	1	15	0	prevention of phosphorylation at this site enhances YY1 cleavage by caspase 7 during apoptosis	
WWOX	Apoptosis; EC 1.1.1.-; Oxidoreductase	Q9NZC7	51741	WWOX	16q23.3-q24.1	human	Y287	PHOSPHORYLATION	457684	LSPTKNDyWAMLAYN		protein degradation				7284	1	1	0		
EGR1	C2H2-type zinc finger protein; DNA binding protein; Transcription factor	P18146	1958	EGR1	5q31.1	human	S104	PHOSPHORYLATION	11423700	YEHLTAEsFPDISLN			transcription, altered		DNA(DISRUPTS)	10274604	1	0	0		
Kv3.3	Membrane protein, integral; Membrane protein, multi-pass	Q63959	16504	Kcnc3		mouse	S9	PHOSPHORYLATION	2840510	LSSVCVWsFRGRQGT	Potassium_chann	activity, inhibited				2831761	1	0	0		
Chk1	EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, CAMK; Protein kinase, Ser/Thr (non-receptor)	O14757	1111	CHEK1	11q24.2	human	S296	PHOSPHORYLATION	447832	GFSKHIQsNLDFSPV		molecular association, regulation; intracellular localization; enzymatic activity, induced	cell cycle regulation; cell growth, altered	14-3-3 gamma(INDUCES); Cdc25A(INDUCES); claspin(INDUCES)		15331012; 1172819; 4600	10	7	4	growth of T47D cells is inhibited in the presence of THIF; Phosphorylated S296 is distributed thoroughout the nucleoplasm and is essential for DNA damage checkpoint. 	
TNNT2	Motility/polarity/chemotaxis; Motor protein	P50752	21956	Tnnt2		mouse	S288	PHOSPHORYLATION	457603	INDNQKVsKTRGKAK	Troponin	phosphorylation	cytoskeletal reorganization			7134	2	0	0	ROCK II induced desensitization to Ca++ and depression in maximal tension.	
ATF-4	DNA binding protein; Transcription factor	P18848	468	ATF4	22q13.1	human	S224	PHOSPHORYLATION	1734100	NDSGICMsPESYLGS		molecular association, regulation		FBW1B(INDUCES)		1713108	1	0	0		
Pin1	EC 5.2.1.8; Isomerase; Nuclear receptor co-regulator	Q9QUR7	23988	Pin1		mouse	S16	PHOSPHORYLATION	447772	PGWEKRMsRSSGRVY	MBD; WW	enzymatic activity, inhibited	translation, altered			14151803	8	1	0		
CSRP1	Cytoskeletal protein; Motility/polarity/chemotaxis	P21291	1465	CSRP1	1q32	human	Y62	PHOSPHORYLATION	2091905	EIYCKSCyGKKYGPK	PHF5; LIM; zf-C3HC4_2	intracellular localization				2249	1	0	0		
Alix	Adaptor/scaffold; Apoptosis	Q8WUM4	10015	PDCD6IP	3p22.3	human	Y319	PHOSPHORYLATION	457636	KKDNDFIyHDRVPDL	BRO1	molecular association, regulation	cell adhesion, altered	Pyk2(INDUCES); Src(INDUCES); FAK(INDUCES)		4304; 2938	2	0	60		
MUC1	Actin binding protein; Cell adhesion; Membrane protein, integral; Motility/polarity/chemotaxis; Nuclear receptor co-regulator	P15941	4582	MUC1	1q21	human	Y1229	PHOSPHORYLATION	448462	SSTDRSPyEKVSAGN		molecular association, regulation		GSK3B(DISRUPTS); CTNNB1(INDUCES)		1350	5	4	427		
PDE6G	EC 3.1.4.17; EC 3.1.4.35; Nucleotide Metabolism - purine; Phosphodiesterase	P04972	281977	PDE6G		cow	T35	PHOSPHORYLATION	450149	PKFKQRQtRQFKSKP	PDE6_gamma	phosphorylation				11270018	5	0	0	phosphorylation of T22 is attenuated in PDE6G T35A mutant	
Bim iso2	Apoptosis	O43521-2	10018	BCL2L11	2q13	human	T56	PHOSPHORYLATION	449071	SCDKSTQtPSPPCQA		activity, induced; molecular association, regulation	apoptosis, induced	LC8(DISRUPTS)		2108	8	0	0		
PLD1	EC 3.1.4.4; Lipid Metabolism - ether lipid; Lipid Metabolism - glycerophospholipid; Motility/polarity/chemotaxis; Phospholipase	Q13393	5337	PLD1	3q26	human	S505	PHOSPHORYLATION	11091057	GSVKRVTsGPSLGSL		enzymatic activity, induced				13354722	1	0	1	in response to glucose deprivation	
CEACAM3	Cell adhesion; Immunoglobulin superfamily; Membrane protein, integral	P40198	1084	CEACAM3	19q13.2	human	Y230	PHOSPHORYLATION	478344	PRTAASIyEELLKHD		molecular association, regulation		PIK3C2A(INDUCES); VAV1(INDUCES)		18021016; 9572	2	0	1	important for bacterial uptake (N. gonorrhoeae) and killing of internalized pathogens;  Vav1 required for CEACAM3-mediated phagocytosis of bacterial pathogens; specific interaction between SH2 domain of VAV1 and ITAM-like sequence of CEACAM3	
ARHGAP5	GTPase activating protein, Rac/Rho; Motility/polarity/chemotaxis	Q13017	394	ARHGAP5	14q12	human	Y306	PHOSPHORYLATION	449920	NHPDYEEyINLEGTR		intracellular localization	cell differentiation, altered			2470	1	0	0		
PSD-95	Adaptor/scaffold	P31016	29495	Dlg4		rat	S295	PHOSPHORYLATION	456936	PTSPRRYsPVAKDLL	PDZ_assoc	activity, induced; intracellular localization				1172826	3	4	0	enhances GluR surface expression and current potentiation	
NFAT1	DNA binding protein; Transcription factor	Q60591	18019	Nfatc2		mouse	S276	PHOSPHORYLATION	447850	ASPQRSRsPSPQPSP			transcription, inhibited			1188	0	1	0		
ITGB2	Cell adhesion; Cell surface; Membrane protein, integral; Motility/polarity/chemotaxis; Receptor, misc.	P11835	16414	Itgb2		mouse	T761	PHOSPHORYLATION	448535	PLFKSATtTVMNPKF			cell motility, induced; cell adhesion, induced			28722117	2	0	0	T-cell homing to lymphocytes	
FOXM1	DNA binding protein; Transcription factor	Q08050	2305	FOXM1	12p13	human	S672	PHOSPHORYLATION	467914	QSAPPLEsPQRLLSS		protein stabilization	transcription, induced			22495316	1	4	0		
HSP27	Chaperone; Motility/polarity/chemotaxis	P04792	3315	HSPB1	7q11.23	human	S78	PHOSPHORYLATION	448402	PAYSRALsRQLSSGV		protein degradation; molecular association, regulation; phosphorylation; activity, induced; sumoylation; ubiquitination; intracellular localization; protein conformation	cell cycle regulation; apoptosis, altered; apoptosis, inhibited; cytoskeletal reorganization; transcription, altered; cell growth, altered	TRAF6(DISRUPTS); TPM1(INDUCES); hnRNP D0(DISRUPTS); HSF1(DISRUPTS)		7229; 21261102; 6804602; 1122; 4280504; 7325707; 8471500; 3886803; 1959; 5892	21	6	31	inhibits cell proliferaction ; Raf/MEK/ERK and p38/MKP-1 phosphorylation; triple mutant (S15A/S78A/S82A)	
Akt1	EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor)	P31750	11651	Akt1		mouse	Y326	PHOSPHORYLATION	447858	EVLEDNDyGRAVDWW	Pkinase	enzymatic activity, induced	apoptosis, altered			449; 15331019	3	2	25		
HTRA2	EC 3.4.21.108; Membrane protein, integral; Mitochondrial; Protease	O43464	27429	HTRA2	2p12	human	S212	PHOSPHORYLATION	477180	RVRVRLLsGDTYEAV	Trypsin_2	intracellular localization; enzymatic activity, inhibited	apoptosis, induced			9376	1	0	2		
NDEL1	Microtubule binding protein; Protease	Q9GZM8	81565	NDEL1	17p13.1	human	T245	PHOSPHORYLATION	3211851	GFGTSPLtPSARISA	NUDE_C	molecular association, regulation; intracellular localization		PAFAH1B1(INDUCES)		9081	2	3	3		
Abi-1	Adaptor/scaffold; Motility/polarity/chemotaxis	Q8CBW3	11308	Abi1		mouse	S88	PHOSPHORYLATION	27115701	SQLRRMEsSINHISQ			cytoskeletal reorganization			27108305	1	1	0	Rac activation and spine maturation	
SLP76	Adaptor/scaffold	Q13094	3937	LCP2	5q35.1	human	K30	UBIQUITINATION	25786202	YFKKLNYkDCEKAVK	SAM_2	ubiquitination				25712655	1	1	0		
CTNNB1	Actin binding protein; Cell adhesion; Motility/polarity/chemotaxis; Nuclear receptor co-regulator; Transcription factor	Q9WU82	84353	Ctnnb1		rat	S37	PHOSPHORYLATION	447582	YLDSGIHsGATTTAP		protein degradation				3803	53	3	2		
PDK1	EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor)	O15530	5170	PDPK1	16p13.3	human	Y9	PHOSPHORYLATION	447696	ARTTSQLyDAVPIQS		protein degradation; molecular association, regulation; phosphorylation; enzymatic activity, induced	transcription, altered	HSP90A(INDUCES); Src(INDUCES)		3400801; 2199	5	1	6	phosphorylation of PDK1 Y373/376; inhibits p53 promoter transcription	
Pin1	EC 5.2.1.8; Isomerase; Nuclear receptor co-regulator	Q13526	5300	PIN1	19p13	human	S65	PHOSPHORYLATION	456481	SHLLVKHsQSRRPSS	Rotamase	protein stabilization				6696	1	0	0		
LIMK1	EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, Ser/Thr (non-receptor); Protein kinase, TKL	P53667	3984	LIMK1	7q11.23	human	S323	PHOSPHORYLATION	459630	KDLGRSEsLRVVCRP		enzymatic activity, induced	cell motility, altered			7665	1	0	0	important for VEGF-induced stress fiber formation	
separase	EC 3.4.22.49; Protease	Q14674	9700	ESPL1	12q	human	S1399	PHOSPHORYLATION	1211206	KVNFSDDsDLEDPVS		enzymatic activity, inhibited		CDK1(INDUCES)		1172817	1	8	0	phosphorylation of S1399 is a key residue in CDK1-dependent inhibition of separase 	
NKCC2	Membrane protein, integral; Membrane protein, multi-pass; Transporter	P55014	20495	Slc12a1		mouse	T96	PHOSPHORYLATION	458227	TNTYYLQtFGHNTMD	AA_permease_N	activity, induced				7338	8	2	0		
VAV1	Guanine nucleotide exchange factor, Rac/Rho; Motility/polarity/chemotaxis	P27870	22324	Vav1		mouse	Y142	PHOSPHORYLATION	448809	ALNDEDIySGLSDQI		molecular association, regulation; protein conformation; activity, inhibited; phosphorylation	cytoskeletal reorganization; transcription, altered; cell growth, altered	VAV1(INDUCES)		13354739; 1976	3	0	0		
NOX4	Cell cycle regulation; EC 1.6.3.-; Membrane protein, integral; Membrane protein, multi-pass; Oxidoreductase	Q9NPH5	50507	NOX4	11q14.2-q21	human	Y491	PHOSPHORYLATION	27930805	WQENRPDyVNIQLYL		molecular association, regulation	cell growth, induced	SHPS1(INDUCES); Grb2(INDUCES)		27902352	1	0	0	mediated by Grb2; Grb2 recruitment to SHPS1	
MEF2D	DNA binding protein; Transcription factor	Q63943	17261	Mef2d		mouse	S437	PHOSPHORYLATION	449407	SIKSEPVsPSRERSP			apoptosis, induced			2865406	3	4	16		
cofilin 1	Cytoskeletal protein; Motility/polarity/chemotaxis	P23528	1072	CFL1	11q13	human	S24	PHOSPHORYLATION	9218418	DMKVRKSsTPEEVKK	Cofilin_ADF	molecular association, regulation	cytoskeletal reorganization	14-3-3 zeta(INDUCES)		25712654	1	4	10	inhibition of depolymerization of actin, cessation of degranulation 	
CD3E	Membrane protein, integral; Receptor, misc.	P07766	916	CD3E	11q23	human	Y188	PHOSPHORYLATION	448918	PPVPNPDyEPIRKGQ	ITAM	molecular association, regulation; phosphorylation		Nck1(DISRUPTS); Nck2(DISRUPTS); EPS8(DISRUPTS)		12063; 2807230	4	11	394		
Cdc25A	EC 3.1.3.48; Motility/polarity/chemotaxis; PHOSPHATASE; Protein phosphatase, dual-specificity	P30304	993	CDC25A	3p21	human	S88	PHOSPHORYLATION	458298	DSGFCLDsPGPLDSK	M-inducer_phosp	protein degradation; ubiquitination	cell cycle regulation	BTRC(INDUCES); FBW1B(INDUCES)		7346; 10353922	3	0	0		
vinculin	Cell adhesion; Cytoskeletal protein; Motility/polarity/chemotaxis	Q64727	22330	Vcl		mouse	Y1065	PHOSPHORYLATION	454003	WVRKTPWyQ______	Vinculin		cell motility, altered			12028119	6	1	20		
Pin1	EC 5.2.1.8; Isomerase; Nuclear receptor co-regulator	Q13526	5300	PIN1	19p13	human	Y23	PHOSPHORYLATION	473849	SRSSGRVyYFNHITN	MBD; WW	molecular association, regulation	cell cycle regulation	KIF20B(INDUCES)		12482265; 626	1	1	3	regulates association to phosphopeptides; in vitro and in vivo	
DVL2	Adaptor/scaffold; Motility/polarity/chemotaxis	O14641	1856	DVL2	17p13.1	human	S597	PHOSPHORYLATION	22682200	RSSGSTRsDGGAGRT	Dsh_C		cytoskeletal reorganization; transcription, inhibited			27619331	1	0	0	neurite outgrowth	
RACK1	Adaptor/scaffold; G protein; G protein, heterotrimeric; G protein, heterotrimeric beta WD; Motility/polarity/chemotaxis; Nuclear receptor co-regulator	P63244	10399	GNB2L1	5q35.3	human	Y52	PHOSPHORYLATION	464119	LTRDETNyGIPQRAL	DUF1416	molecular association, regulation; protein conformation	cell motility, altered; cell adhesion, altered; cell growth, altered	FAK(INDUCES)		7889906	2	0	227		
PVR	Immunoglobulin superfamily; Membrane protein, integral; Motility/polarity/chemotaxis; Receptor, misc.	P15151	5817	PVR	19q13.2	human	Y398	PHOSPHORYLATION	450742	SANGHVSySAVSREN	DUF2371	molecular association, regulation				4076	1	4	17		
4E-BP1	Translation; Translation initiation	Q62622	116636	Eif4ebp1		rat	T45	PHOSPHORYLATION	447496	GGTLFSTtPGGTRII	eIF_4EBP	molecular association, regulation; phosphorylation	translation, altered	eIF4E(DISRUPTS)		15658714; 6650; 842	90	20	90		
survivin	Apoptosis	O15392	332	BIRC5	17q25	human	S20	PHOSPHORYLATION	485776	FLKDHRIsTFKNWPF	BIR	molecular association, regulation; intracellular localization; phosphorylation	cell cycle regulation; apoptosis, induced	XIAP(DISRUPTS)		17675026; 12060; 14058620	4	0	0	 stimulates Aurora B activation and increases phosphorylation of CENPA S7; critical for accurate chromosome segregation	
neurogenin 2	Transcription factor	P70447	11924	Neurog2		mouse	S231	PHOSPHORYLATION	2255101	SPYSCTLsPASPGSD		molecular association, regulation	cell growth, altered	LDB1(INDUCES)		2704319	2	0	0	important for spinal motor neuron differentiation	
AML2	DNA binding protein; Transcription factor	Q13761	864	RUNX3	1p36	human	S149	PHOSPHORYLATION	6097701	GRSGRGKsFTLTITV	Runt	protein stabilization; intracellular localization	cell cycle regulation; transcription, altered			6095014	1	1	1		
Grb10	Adaptor/scaffold	Q13322	2887	GRB10	7p12.2	human	S150	PHOSPHORYLATION	454185	PELCGPGsPPVLTPG		protein stabilization; activity, inhibited				19044700; 6334	2	3	0		
ADRB2	GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR	P07550	154	ADRB2	5q31-q32	human	S355	PHOSPHORYLATION	458916	KAYGNGYsSNGNTGE		protein degradation; molecular association, regulation; receptor desensitization, altered; receptor internalization, altered		ARRB2(INDUCES)		9394; 8115; 5354441; 7454; 14551416; 14148600	15	0	0		
IL2RB	Membrane protein, integral; Receptor, cytokine	P14784	3560	IL2RB	22q13.1	human	Y536	PHOSPHORYLATION	450934	LPLNTDAyLSLQELQ		molecular association, regulation	apoptosis, inhibited; cell growth, altered	STAT5A(INDUCES); Shb(INDUCES); STAT5B(INDUCES)		8569; 8607	2	2	2		
p90RSK	EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor); Translation	P18653	20111	Rps6ka1		mouse	S369	PHOSPHORYLATION	447990	HQLFRGFsFVATGLM	Pkinase_C	enzymatic activity, induced				6759	45	26	62		
diaphanous 2 iso4	Cytoskeletal protein; Motility/polarity/chemotaxis	Q17R91	1730	DIAPH2	Xq21.33	human	T66	PHOSPHORYLATION	11147321	ITSFRKStVKKEKPL			cell cycle regulation; chromatin organization, altered; cytoskeletal reorganization			18668219	1	0	0	mutation of this site disrupts metaphase chromosome alignment	
MEF2D	DNA binding protein; Transcription factor	Q63943	17261	Mef2d		mouse	S180	PHOSPHORYLATION	449933	LTDPRLLsPQQPALQ		activity, induced				2504	1	16	11		
FANCD2	DNA repair	Q9BXW9	2177	FANCD2	3p26	human	S331	PHOSPHORYLATION	11315004	KSKGRASsSGNQESS		molecular association, regulation; ubiquitination		BRCA2(INDUCES)		11262504	1	1	0	confers resistance to mitomycin C	
BAD	Apoptosis	Q61337	12015	Bad		mouse	T201	PHOSPHORYLATION	450485	NLGKGGStPSQ____	Bcl-2_BAD	activity, induced; molecular association, regulation	apoptosis, inhibited	Bcl-xL(DISRUPTS)		4264908; 3112	3	0	0		
YAP1	Transcription, coactivator/corepressor	P46938	22601	Yap1		mouse	S112	PHOSPHORYLATION	448847	PQHVRAHsSPASLQL		molecular association, regulation; intracellular localization; activity, inhibited	transcription, altered; transcription, inhibited	14-3-3 epsilon(INDUCES); CTNNA1(INDUCES)		7550823; 6581; 20834110	25	14	164	cytoplasmic localization 	
CK2-B	KINASE; Protein kinase, regulatory subunit	Q5SRQ6	1460	CSNK2B	6p21.3	human	S23	PHOSPHORYLATION	455683	ADVKMSSsEEVSWIS		protein stabilization				5825	1	6	0		
C3aR	GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR	Q16581	719	C3AR1	12p13.31	human	T463	PHOSPHORYLATION	17552878	AAFSEELtRSTHCPS		receptor internalization, induced; molecular association, regulation	transcription, inhibited	ARRB1(INDUCES)		27132477	1	1	0		
NFM	Cytoskeletal protein	P08553	18040	Nefm		mouse	S645	PHOSPHORYLATION	451040	KKEVTKEsPKEEKVE			cytoskeletal reorganization			7072905	1	4	0	slightly altered axoplasmic organization in 7S/A mice mutant	
TGFBR2	EC 2.7.11.30; KINASE; Kinase, protein; Membrane protein, integral; Protein kinase, Ser/Thr (receptor); Protein kinase, TKL	P37173	7048	TGFBR2	3p22	human	Y424	PHOSPHORYLATION	2869602	GQVGTARyMAPEVLE	Pkinase	enzymatic activity, induced	transcription, altered			2852639	2	0	0		
P130Cas	Adaptor/scaffold; Motility/polarity/chemotaxis	Q61140	12927	Bcar1		mouse	Y414	PHOSPHORYLATION	448720	SVVDDGVyAVPPPAE			cell motility, altered			15331022	10	15	94	SH3 and CCH domains are required for P130Cas tyrosine phosphorylation and promoting cell migration.   	
XIAP	Apoptosis; EC 6.3.2.-; Ligase; UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase	P98170	331	XIAP	Xq25	human	S87	PHOSPHORYLATION	450336	VGRHRKVsPNCRFIN	BIR	protein stabilization	apoptosis, altered; apoptosis, inhibited			3097; 1173019	3	0	0		
PITPNA	Lipid binding protein	P53810	18738	Pitpna		mouse	S166	PHOSPHORYLATION	450933	EDPAKFKsVKTGRGP	IP_trans	intracellular localization				3188	2	0	0	Stimulation of NIH3T3 fibroblasts by PMA or PDGF induced the rapid relocalization of PI-TPalpha to perinuclear Golgi structures. 	
Lyn	EC 2.7.10.2; KINASE; Kinase, protein; Protein kinase, TK; Protein kinase, tyrosine (non-receptor)	P25911	17096	Lyn		mouse	Y508	PHOSPHORYLATION	447624	YTATEGQyQQQP___		enzymatic activity, inhibited				707; 8287	11	25	1558		
PKG1 iso2	EC 2.7.11.12; KINASE; Kinase, protein; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor)	Q13976-2	5592	PRKG1	10q11.2	human	S80	PHOSPHORYLATION	452147	RTKRQAIsAEPTAFD	Med4; Casc1	enzymatic activity, induced				8746	4	0	0		
SSTR3	GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR	P30936	171044	Sstr3		rat	S351	PHOSPHORYLATION	456710	VRSQEPGsGPPEKTE		receptor desensitization, altered; receptor internalization, altered				4062	1	0	0		
ICK	EC 2.7.11.22; KINASE; Kinase, protein; Protein kinase, CMGC; Protein kinase, Ser/Thr (non-receptor)	Q9JKV2	56542	Ick		mouse	T157	PHOSPHORYLATION	456051	IRSRPPYtDYVSTRW	Pkinase	enzymatic activity, induced				6637	2	12	86		
GTF2A1	Transcription, coactivator/corepressor	P52655	2957	GTF2A1	14q31.1	human	S321	PHOSPHORYLATION	448630	LNSEDDVsDEEGQEL	TFIIA; Syndecan		transcription, induced			1829	1	1	2		
SIAH2	EC 6.3.2.-; EC 6.3.2.19; Ligase; Transcription, coactivator/corepressor; UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase	O43255	6478	SIAH2	3q25	human	T26	PHOSPHORYLATION	5393503	PPPQPQHtPSPAAPP		protein degradation; molecular association, regulation; intracellular localization; enzymatic activity, induced	cytoskeletal reorganization	HIPK2(DISRUPTS)		5354423; 26341714	4	1	0		
MDC1	Cell cycle regulation	Q14676	9656	MDC1	6p21.3	human	S299	PHOSPHORYLATION	477757	SQPPGEDsDTDVDDD		molecular association, regulation	cell cycle regulation	NBS1(INDUCES)		4042508	1	12	18	MDC1-NBS1 interaction regulates intra-S-phase checkpoint activation	
eEF1A1	Translation; Translation elongation	P68104	1915	EEF1A1	6q14.1	human	S300	PHOSPHORYLATION	15629200	EMHHEALsEALPGDN	GTP_EFTU_D2	molecular association, regulation	cell cycle regulation; translation, altered; carcinogenesis, altered; cell growth, altered		RNA(NOT_REPORTED)	15562529	1	0	0	inhibits aa-tRNA binding by eEF1A-1 	
CREB	DNA binding protein; Transcription factor	Q01147	12912	Creb1		mouse	S121	PHOSPHORYLATION	451811	SVDSVTDsQKRREIL	pKID	intracellular localization				9265	10	0	0	Preferentially localized to the soluble nucleoplasmic fraction.	
SLP76	Adaptor/scaffold	Q13094	3937	LCP2	5q35.1	human	Y145	PHOSPHORYLATION	448220	PVEDDADyEPPPSND		molecular association, regulation; phosphorylation	cytoskeletal reorganization; transcription, induced	Nck1(INDUCES); VAV1(INDUCES)		5955628; 25725911; 2630609; 2943	14	0	0		
SP7	C2H2-type zinc finger protein; DNA binding protein; Transcription factor	Q8VI67	170574	Sp7		mouse	S77	PHOSPHORYLATION	15334101	GLLSPAGsPPAPASG		activity, induced; molecular association, regulation	transcription, altered	SMARCA4(INDUCES); p300(INDUCES)		15235204	1	0	0		
NOXA	Apoptosis; Mitochondrial	Q13794	5366	PMAIP1	18q21.32	human	S13	PHOSPHORYLATION	17790900	ARKNAQPsPARAPAE			apoptosis, altered; carcinogenesis, altered; cell growth, altered			17675018	1	2	0	regulated by glucose	
GSK3B	EC 2.7.11.1; EC 2.7.11.26; KINASE; Kinase, protein; Protein kinase, CMGC; Protein kinase, Ser/Thr (non-receptor)	P49841	2932	GSK3B	3q13.3	human	S9	PHOSPHORYLATION	449111	SGRPRTTsFAESCKP		protein degradation; intracellular localization; enzymatic activity, inhibited; activity, inhibited; phosphorylation	apoptosis, altered; cell differentiation, induced; cell motility, altered; apoptosis, inhibited; cytoskeletal reorganization; cell adhesion, altered; transcription, altered; cell growth, altered			7124717; 4914015; 6104; 5683; 7674; 15331014; 6115917; 3537; 6438; 6115915; 6671; 12525200; 6541; 6484; 6930; 5601; 6931; 7183; 25725907; 6504; 687; 6512; 7406	345	20	210		
eEF2K	EC 2.7.11.20; KINASE; Kinase, protein; Protein kinase, ATYPICAL; Protein kinase, Ser/Thr (non-receptor); Translation	O00418	29904	EEF2K	16p12.2	human	S359	PHOSPHORYLATION	447826	GTEEKCGsPQVRTLS		enzymatic activity, inhibited				4207607; 1059	5	1	6		
NUSAP1	Cell cycle regulation	Q9BXS6	51203	NUSAP1	15q15.1	human	T300	PHOSPHORYLATION	7989914	HKRSLTKtPARKSAH		molecular association, regulation; intracellular localization	cytoskeletal reorganization			22723906	1	2	2	inhibits NUSAP binding to microtubules in mitosis	
ataxin-3 iso2	DNA repair; EC 3.4.19.12; EC 3.4.22.-; Protease; Transcription regulation; Ubiquitin-specific protease	P54252-2	4287	ATXN3	14q21	human	S236	PHOSPHORYLATION	9441003	LQRALALsRQEIDME	OmpH; Dicty_REP; UIM	activity, induced; intracellular localization	transcription, altered			9201021	1	0	0		
ZAP70	EC 2.7.10.2; KINASE; Kinase, protein; Protein kinase, TK; Protein kinase, tyrosine (non-receptor)	P43404	22637	Zap70		mouse	Y314	PHOSPHORYLATION	448867	MPMDTSVyESPYSDP		molecular association, regulation; phosphorylation		CD3Z(INDUCES)		2762	6	4	285	leads to TCR-zeta and ERK phosphorylation	
p70S6K	EC 2.7.11.-; EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor); Translation	P67999	83840	Rps6kb1		rat	S434	PHOSPHORYLATION	448356	SFEPKIRsPRRFIGS		phosphorylation; enzymatic activity, induced				2670105	25	1	0	required for p70S6K T412 phosphorylation which leads to enzymatic activation	
RANBP3	Adaptor/scaffold	Q9H6Z4	8498	RANBP3	19p13.3	human	S126	PHOSPHORYLATION	460735	VKRERTSsLTQFPPS		molecular association, regulation; intracellular localization; activity, inhibited		RAN(INDUCES)		4248205	3	24	128	inhibits RCC1 activity	
p53	Activator protein; DNA binding protein; Motility/polarity/chemotaxis; Nuclear receptor co-regulator; Transcription factor; Tumor suppressor	P02340	22059	Tp53		mouse	S309	PHOSPHORYLATION	447530	LPTCTSAsPPQKKKP		acetylation	carcinogenesis, altered; transcription, altered			18378507; 8707	37	16	7	S312AA knock-in mice are more suseptible to tumorigenesis. ; substitution of either alanine or aspartic acid at this site induces acetylation at K370 (K373 in human)	
PKD1	Autophagy; EC 2.7.11.13; KINASE; Kinase, protein; Motility/polarity/chemotaxis; Protein kinase, CAMK; Protein kinase, Ser/Thr (non-receptor)	Q62101	18760	Prkd1		mouse	S916	PHOSPHORYLATION	447632	KALSERVsIL_____		molecular association, regulation; protein conformation; enzymatic activity, induced	cell motility, altered; cytoskeletal reorganization	ITGB1(INDUCES)		1173026; 830; 2449	33	6	0		
XRCC1	DNA repair	P18887	7515	XRCC1	19q13.2	human	S485	PHOSPHORYLATION	451510	QDNGAEDsGDTEDEL		molecular association, regulation; intracellular localization		Pnk1(INDUCES)		3651	2	7	0	regulates rapid repair of cellular DNA single-strand breaks	
SgK307	Cancer Testis Antigen (CTA); KINASE; Kinase, protein; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor)	Q8IWB6	56155	TEX14	17q22	human	T618	PHOSPHORYLATION	25158902	EEASSPStGQPSLCS		molecular association, regulation; intracellular localization		PLK1(INDUCES)		25082834	1	0	0		
GLI3	C2H2-type zinc finger protein; Transcription factor	P10071	2737	GLI3	7p13	human	S907	PHOSPHORYLATION	15501388	TDASRRSsEASQSDG		protein processing	transcription, inhibited			25779400	1	0	0		
IRS1	Adaptor/scaffold; Motility/polarity/chemotaxis	P35569	16367	Irs1		mouse	S1097	PHOSPHORYLATION	453434	GCRRRHSsETFSAPT		activity, inhibited				4146	7	19	98		
Ikaros	C2H2-type zinc finger protein; DNA binding protein; Transcription factor	Q03267	22778	Ikzf1		mouse	S195	PHOSPHORYLATION	451356	TGHLRTHsVGKPHKC	zf-H2C2_2	intracellular localization				3560	1	0	0		
NCAM-L1	Cell adhesion; Membrane protein, integral	Q90933	396059			chicken	Y1199	PHOSPHORYLATION	456529	KDETFGEyRSLESEA	Bravo_FIGEY	intracellular localization				6718	10	1	10	Alanine mutation directs protein to apical part of MDCK cells;  phosphorylation functions in the sort of protein to basolateral surface.	
CaMK4	EC 2.7.11.17; KINASE; Kinase, protein; Protein kinase, CAMK; Protein kinase, Ser/Thr (non-receptor)	P08414	12326	Camk4		mouse	T196	PHOSPHORYLATION	448164	EHQVLMKtVCGTPGY	Pkinase	activity, induced	transcription, altered; signaling pathway regulation			18378501	10	6	7	CAMK/CREB signaling pathway regulates transcription, activity of sympathetic neurons, and bone mass accrual.	
MSK2	EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor)	O75676	8986	RPS6KA4	11q11-q13	human	S347	PHOSPHORYLATION	447952	PVYSPPGsPPPGDPR	Pkinase_C	enzymatic activity, induced				1264	1	17	4		
PAK3	EC 2.7.1.; EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, STE; Protein kinase, Ser/Thr (non-receptor)	O75914	5063	PAK3	Xq23	human	S154	PHOSPHORYLATION	448123	VNNQKYMsFTSGDKS	Ribosomal_60s		cytoskeletal reorganization			9007	3	3	0	Mutation of any of the 4 serines/threonines to alanine reduced the AILIM/ICOS-induced elongation ratio in activated T cells.  Three sites are believed to be autophosphorylation sites, and one is believed to be an Akt1 site.  Treatment with Akt inhibitor shows a reduction in this elongation ratio.	
PDGFRB	EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Protein kinase, TK; Protein kinase, tyrosine (receptor)	P09619	5159	PDGFRB	5q33.1	human	Y579	PHOSPHORYLATION	447521	VSSDGHEyIYVDPMQ		molecular association, regulation; phosphorylation; enzymatic activity, induced	cell growth, altered	Shc1(INDUCES); RASA1(INDUCES); PLCG1(INDUCES); PIK3R1(INDUCES)		2280; 2852641; 1225; 8841; 5011222	11	1	0		
WAVE1	Cytoskeletal protein; Motility/polarity/chemotaxis	Q5BJU7		Wasf1		rat	S441	PHOSPHORYLATION	7979602	PPGIRPSsPVTVAAL		intracellular localization	cytoskeletal reorganization			7910501	3	0	0		
Bim	Apoptosis	O88498	64547	Bcl2l11		rat	S65	PHOSPHORYLATION	449330	GPLAPPAsPGPFATR		activity, induced; protein degradation; molecular association, regulation	apoptosis, induced	Pin1(INDUCES)		4645; 3341; 2429801; 2865410; 4588	18	0	1		
RABEP1	Vesicle protein	Q15276	9135	RABEP1	17p13.2	human	S407	PHOSPHORYLATION	468548	DGLRRAQsTDSLGTS		receptor recycling, induced	cell motility, induced	Rab4(INDUCES)		26341740	1	28	568	 invasion into Matrigel;  persistent directional migration; EGFR and integrin recycling	
RPL13A	Ribosomal protein; Translation	P40429	23521	RPL13A	19q13.3	human	S77	PHOSPHORYLATION	5594501	PYHFRAPsRIFWRTV	Ribosomal_L13	activity, induced; protein degradation; molecular association, regulation; ubiquitination	translation, altered; translation, inhibited	GAPDH(INDUCES)		5354436; 25712608	3	2	1	essential for GAIT-mediated translational silencing of inflammatory genes; Phosphorylation is required for RPLl3A release from ribosome. GAPDH binds to phosphorylated S77 and prevents degradation. 	
CACNA1B	Channel, calcium; Membrane protein, integral; Membrane protein, multi-pass	Q02294	257648	Cacna1b		rat	S2132	PHOSPHORYLATION	465550	YSCDRFGsREPPQPK		activity, induced				6337819; 7994	2	0	0		
TWIST1	Cell development/differentiation; DNA binding protein; Inhibitor protein; Transcription regulation	Q15672	7291	TWIST1	7p21.2	human	S68	PHOSPHORYLATION	18905000	GGGDEPGsPAQGKRG		protein stabilization	carcinogenesis, altered			18837503	1	2	0	 ; promotes TGFbeta-induced cell invasion	
FOXO4	DNA binding protein; Transcription factor	Q9WVH3	54601	Foxo4		mouse	T32	PHOSPHORYLATION	455572	QSRPRSCtWPLPRPD		molecular association, regulation	transcription, altered	14-3-3 zeta(INDUCES)		5458	5	6	31		
FGFR1	EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Protein kinase, TK; Protein kinase, tyrosine (receptor)	P11362	2260	FGFR1	8p12	human	Y766	PHOSPHORYLATION	447922	ALTSNQEyLDLSMPL		molecular association, regulation		PLCG1(INDUCES)		1091	8	0	0		
SRC-3	ACETYLTRANSFERASE; Acetyltransferase; EC 2.3.1.48; Motility/polarity/chemotaxis; Nuclear receptor co-regulator; Transcription, coactivator/corepressor	Q9Y6Q9	8202	NCOA3	20q12	human	Y1357	PHOSPHORYLATION	4668109	HPQAASIyQSSEMKG		molecular association, regulation	transcription, altered; cell growth, altered	CARM1(INDUCES); p300(INDUCES); ER-alpha(INDUCES)		4641412	1	1	0		
FAK	EC 2.7.1.112; EC 2.7.10.2; KINASE; Kinase, protein; Protein kinase, TK; Protein kinase, tyrosine (non-receptor)	Q00944	396416	PTK2		chicken	Y397	PHOSPHORYLATION	447887	SVSETDDyAEIIDEE		molecular association, regulation		Src(INDUCES)		4894709; 1083	234	21	470		
SLC6A4	Membrane protein, integral; Membrane protein, multi-pass; Transporter	P31645	6532	SLC6A4	17q11.2	human	S611	PHOSPHORYLATION	7576400	FKERIIKsITPETPT		activity, induced; molecular association, regulation		vimentin(DISRUPTS)		7543512	1	0	1		
Rap1GAP	GTPase activating protein, Ras; Motility/polarity/chemotaxis	XP_233609	313644	Rap1gap		rat	S472	PHOSPHORYLATION	1210678	VIRSRSQsMDAMGLS			cytoskeletal reorganization			6804215	1	7	72	controls dendritic spine morphology	
HMGN2	DNA binding protein	P05204	3151	HMGN2	1p36.1	human	S25	PHOSPHORYLATION	3146800	KDEPQRRsARLSAKP	HMG14_17	intracellular localization				8551	1	7	5	Phosphorylation facilitates localization to non-nuclear pools.	
caveolin-1	Adaptor/scaffold; Motility/polarity/chemotaxis; Nuclear receptor co-regulator	P33724	403980	CAV1		dog	S80	PHOSPHORYLATION	448421	AEPEGTHsFDGIWKA	Caveolin	intracellular localization				1005	2	0	0	phosphorylation of this site regulates secretion of caveolin-1 in the pancreatic acinar cells AR42J	
TRPV1	Channel, cation; Membrane protein, integral; Membrane protein, multi-pass; Receptor, misc.	O35433	83810	Trpv1		rat	T406	PHOSPHORYLATION	473576	IAYSSSEtPNRHDML		phosphorylation				9193	2	0	0	Cdk5 phosphorylation of VR1 T406 in DRG may alter pain sensation in Cdk5 CoKo mice. 	
JAM-A	Cell adhesion; Membrane protein, integral	Q9Y624	50848	F11R	1q21.2-q21.3	human	S284	PHOSPHORYLATION	467829	KVIYSQPsARSEGEF		intracellular localization				8590	2	27	19		
HCN4	Channel, cation; Membrane protein, integral; Membrane protein, multi-pass	O70507	330953	Hcn4		mouse	T1138	PHOSPHORYLATION	15103405	HVTLPRKtSSGSLPP		activity, induced				15022705	1	0	0	required for PKA to shift the voltage dependence of HCN4	
ITGB1	Cell adhesion; Cell surface; Membrane protein, integral; Motility/polarity/chemotaxis; Receptor, misc.	P09055	16412	Itgb1		mouse	S785	PHOSPHORYLATION	452040	GENPIYKsAVTTVVN	Integrin_b_cyt		cell adhesion, altered			10425104	5	4	16		
SLC4A3	Membrane protein, integral; Membrane protein, multi-pass; Transporter	P23348	24781	Slc4a3		rat	S67	PHOSPHORYLATION	10212000	EKPSRSYsERDFEFH	TFIIA	activity, induced				10144206	1	1	0		
syndecan-2	Cell adhesion; Cell surface; Membrane protein, integral; Motility/polarity/chemotaxis	P34900	25615	Sdc2		rat	Y179	PHOSPHORYLATION	448375	RKKDEGSyDLGERKP	Glycophorin_A; Herpes_gE; Syndecan	molecular association, regulation	cytoskeletal reorganization	EphB2(INDUCES)		1468	2	1	6		
TRAF2	Autophagy; EC 6.3.2.-; Ligase; UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase	Q12933	7186	TRAF2	9q34	human	S11	PHOSPHORYLATION	5397201	ASVTPPGsLELLQPG		molecular association, regulation	apoptosis, inhibited			5354435	2	4	0	;  required for TRAF2 association with a cytoplasmic complex containing RIP1 and IKK; important for TNF alpha-induced IKK activation	
InsR	EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Protein kinase, TK; Protein kinase, tyrosine (receptor)	P06213	3643	INSR	19p13.3-p13.2	human	S1033	PHOSPHORYLATION	454090	LRELGQGsFGMVYEG	Pkinase_Tyr	phosphorylation				8570	5	0	0	alanine mutations of S1033, S1062, and S1064 increases tyrosine autophosphorylation of InsR	
DAP3	Apoptosis; Mitochondrial; Nuclear receptor co-regulator	P51398	7818	DAP3	1q22	human	S215	PHOSPHORYLATION	2226204	YVWNKREsTEKGSPL	DAP3		apoptosis, induced			2195711	1	1	0		
CD22 iso4	Cell surface; Membrane protein, integral	Q3U0M3	12483	Cd22		mouse	Y828	PHOSPHORYLATION	450943	QKRPMGDyENVNPSC		molecular association, regulation		Grb2(INDUCES)		7708800	4	0	1		
MSK1	EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor)	O75582	9252	RPS6KA5	14q31-q32.1	human	S360	PHOSPHORYLATION	448215	TEMDPTYsPAALPQS	Pkinase_C	protein conformation; enzymatic activity, induced				11751	5	1	15		
SYT2	Calcium-binding protein; Lipid binding protein; Membrane protein, integral; Vesicle protein	P46097	20980	Syt2		mouse	T202	PHOSPHORYLATION	454031	ETKVHRKtLNPAFNE	C2	molecular association, regulation				4179	1	0	0	phosphorylation of this site modulates synaptotagmin II binding to phospholipid vesicles (via its C2 domain) 	
MafA	DNA binding protein; Transcription factor	Q8CF90	378435	Mafa		mouse	S61	PHOSPHORYLATION	1320401	PLSTPCSsVPSSPSF		molecular association, regulation		MafA(INDUCES)	DNA(NOT_REPORTED)	13326312	3	0	0		
TEC	EC 2.7.10.2; KINASE; Kinase, protein; Protein kinase, TK; Protein kinase, tyrosine (non-receptor)	P42680	7006	TEC	4p12	human	Y519	PHOSPHORYLATION	447891	RYVLDDQyTSSSGAK	Pkinase_Tyr	phosphorylation				2955	1	12	325	Y518F mutant could not phosphorylate BDP1.	
KSR2 iso2	KINASE; Kinase, protein; Protein kinase, Ser/Thr (non-receptor); Protein kinase, TKL	ABF74604	333050	Ksr2		mouse	S471	PHOSPHORYLATION	4721669	ARLVRTEsVPCDINN		molecular association, regulation; intracellular localization		14-3-3 beta(INDUCES)		7890600	1	6	2		
ER-alpha	DNA binding protein; Nuclear receptor	P03372	2099	ESR1	6q25.1	human	K266	ACETYLATION	461005	RRGGRMLkHKRQRDD		activity, induced; molecular association, regulation	transcription, altered		DNA(INDUCES)	11006907; 7811	2	2	0	K266/268Q or K266/268R mutations confer resistance to repression by BRCA1	
PTP1B	EC 3.1.3.48; Motility/polarity/chemotaxis; PHOSPHATASE; Phosphatase; Protein phosphatase, tyrosine (non-receptor)	P18031	5770	PTPN1	20q13.1-q13.2	human	Y153	PHOSPHORYLATION	449314	SEDIKSYyTVRQLEL	Y_phosphatase	molecular association, regulation		InsR(INDUCES)		2178	2	0	0		
p27Kip1	Cell cycle regulation; Inhibitor protein; Protein kinase, regulatory subunit	P46527	1027	CDKN1B	12p13.1-p12	human	T198	PHOSPHORYLATION	448781	PGLRRRQt_______		protein degradation; protein stabilization; molecular association, regulation; intracellular localization	cell cycle regulation; cell growth, altered	14-3-3 sigma(INDUCES); 14-3-3 theta(INDUCES); 14-3-3 epsilon(INDUCES); CDK2(DISRUPTS); CDK4(INDUCES); 14-3-3 eta(INDUCES)		4324809; 11999201; 2582608; 7251; 4971001; 1940; 2982; 2996900; 2665603	19	0	6		
MCPIP1	EC 3.1.-.-; Hydrolase	Q5D1E7	230738	Zc3h12a		mouse	S439	PHOSPHORYLATION	22730006	CLDSGIGsLESQMSE		protein degradation; molecular association, regulation; ubiquitination	RNA stability, induced	BTRC(INDUCES)		22723924	1	0	0	phosphorylation followed by degradation of ZC3H12A (aka regnase-1) augments IL-6 mRNA stability	
Chk2	EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, CAMK; Protein kinase, Ser/Thr (non-receptor)	O96017	11200	CHEK2	22q12.1	human	S456	PHOSPHORYLATION	981404	PEVWAEVsEKALDLV	Pkinase	protein degradation; ubiquitination	apoptosis, induced			970008	1	1	0	reduction in apoptotic response to DNA damage	
IHPK2	EC 2.7.4.21; Kinase, other; Motility/polarity/chemotaxis	Q9UHH9	51447	IP6K2	3p21.31	human	S347	PHOSPHORYLATION	478422	RPEVVLDsDAEDLED	IPK	protein degradation; ubiquitination	apoptosis, induced; cell growth, altered	TRAF2(INDUCES)	DNA(INDUCES)	18021026; 9585	2	1	0	induces NFkB-DNA binding	
BLM	DNA repair; DNA replication; EC 3.6.1.-; EC 3.6.4.12; Helicase	P54132	641	BLM	15q26.1	human	S144	PHOSPHORYLATION	467079	KKLEFSSsPDSLSTI			cell cycle regulation			8135	1	4	2	prevents early mitotic exit, necessary for mitotic arrest	
DYRK1A	EC 2.7.12.1; EC 2.7.12.2; KINASE; Kinase, protein; Protein kinase, CMGC; Protein kinase, dual-specificity	Q13627	1859	DYRK1A	21q22.13	human	S529	PHOSPHORYLATION	475065	SNSGRARsDPTHQHR		molecular association, regulation; enzymatic activity, induced		14-3-3 beta(INDUCES)		9245	2	3	0	14-3-3 binding increases catalytic activity of DYRK1A.  	
KIF23 iso2	Microtubule binding protein; Motility/polarity/chemotaxis; Motor protein	Q02241-2	9493	KIF23	15q23	human	S708	PHOSPHORYLATION	2902205	IRLRHRRsRSAGDRW		intracellular localization	cell cycle regulation			14551400	3	1	0		
IkB-beta	Inhibitor protein	Q15653	4793	NFKBIB	19q13.1	human	S19	PHOSPHORYLATION	447917	DADEWCDsGLGSLGP		protein degradation				1125	5	0	0		
EphA3	EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Protein kinase, TK; Protein kinase, tyrosine (receptor)	P29319	13837	Epha3		mouse	Y602	PHOSPHORYLATION	449913	TYVDPHTyEDPTQAV			carcinogenesis, altered; cell motility, altered			15278817	3	6	44		
ETV1	DNA binding protein; Transcription factor	P50549	2115	ETV1	7p21.3	human	S191	PHOSPHORYLATION	3059602	HRFRRQLsEPCNSFP	ETS_PEA3_N	activity, induced	transcription, induced			8495	3	1	3		
FANCG	DNA repair	O15287	2189	FANCG	9p13	human	S387	PHOSPHORYLATION	454240	PRFSPPPsPPGPCMP	TPR_16	activity, induced				4241	2	0	0		
IL10RA	Membrane protein, integral; Receptor, cytokine	Q13651	3587	IL10RA	11q23	human	Y446	PHOSPHORYLATION	449607	AAVAFQGyLRQTRCA		molecular association, regulation		CSRP1(INDUCES)		2249	1	0	0		
PKD1	Autophagy; EC 2.7.11.13; KINASE; Kinase, protein; Motility/polarity/chemotaxis; Protein kinase, CAMK; Protein kinase, Ser/Thr (non-receptor)	Q9WTQ1	85421	Prkd1		rat	S744	PHOSPHORYLATION	448589	ARIIGEKsFRRSVVG	Pkinase	enzymatic activity, induced				2439	48	7	14		
HER3	EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Protein kinase, TK; Protein kinase, tyrosine (receptor)	Q62799	29496	Erbb3		rat	Y1219	PHOSPHORYLATION	448639	GSLEELGyEYMDVGS		molecular association, regulation; phosphorylation		PIK3CB(INDUCES); PIK3R1(INDUCES)		1836	2	0	1	induces phosphorylation of Akt1.	
Ret	EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Protein kinase, TK; Protein kinase, tyrosine (receptor)	P07949	5979	RET	10q11.2	human	Y687	PHOSPHORYLATION	449892	AQAFPVSySSSGARR		molecular association, regulation	cell growth, altered	SHP-2(INDUCES)		15235208	3	2	29		
PPP1R16B	Motility/polarity/chemotaxis; Protein phosphatase, regulatory subunit	Q95N27	282091	PPP1R16B		cow	S337	PHOSPHORYLATION	486245	SSLSRRTsSAGSRGK			cytoskeletal reorganization			12058	1	0	0		
PKCD	EC 2.7.10.2; EC 2.7.11.13; KINASE; Kinase, protein; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor)	P09215	170538	Prkcd		rat	Y332	PHOSPHORYLATION	450077	IPDNNGTyGKIWEGS		molecular association, regulation; enzymatic activity, induced	apoptosis, induced	Shc1(INDUCES)		4313625; 970055; 5982; 3077	12	13	543		
MYPT1	Motility/polarity/chemotaxis; Protein phosphatase, regulatory subunit	Q10728	116670	Ppp1r12a		rat	T855	PHOSPHORYLATION	452075	PREKRRStGVSFWTQ		intracellular localization; activity, inhibited				5930036	28	0	17		
AR	DNA binding protein; Nuclear receptor; Transcription factor	P10275	367	AR	Xq12	human	S256	PHOSPHORYLATION	449806	VEALEHLsPGEQLRG	Androgen_recep		transcription, altered			8049	3	1	1		
HER3	EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Protein kinase, TK; Protein kinase, tyrosine (receptor)	Q62799	29496	Erbb3		rat	Y1273	PHOSPHORYLATION	449857	AGGAGGDyAAMGACP		molecular association, regulation; phosphorylation		PIK3CB(INDUCES); PIK3R1(INDUCES)		1836	2	4	52	induces phosphorylation of Akt1.	
p53	Activator protein; DNA binding protein; Motility/polarity/chemotaxis; Nuclear receptor co-regulator; Transcription factor; Tumor suppressor	P04637	7157	TP53	17p13.1	human	S149	O-GlcNAc	5148303	PVQLWVDsTPPPGTR	P53	protein stabilization; ubiquitination; phosphorylation				8918	1	1	0	decreases p53 T155 phosphorylation;  decreases p53 ubiquitination 	
vimentin	Cytoskeletal protein; Motility/polarity/chemotaxis	P08670	7431	VIM	10p13	human	S10	PHOSPHORYLATION	455451	TRSVSSSsYRRMFGG	Filament_head		cell motility, altered			7549203	3	4	1		
Tel	DNA binding protein; Motility/polarity/chemotaxis; Transcription factor	P41212	2120	ETV6	12p13	human	K99	SUMOYLATION	2884400	KALLLLTkEDFRYRS	SAM_PNT	intracellular localization	transcription, induced			2415909	2	0	0		
ERK5	EC 2.7.11.24; KINASE; Kinase, protein; Protein kinase, CMGC; Protein kinase, Ser/Thr (non-receptor)	Q13164	5598	MAPK7	17p11.2	human	S720	PHOSPHORYLATION	3195185	VTQQLSKsQVEDPLP		intracellular localization; enzymatic activity, inhibited	transcription, altered			19084403	1	3	0		
Gab1	Adaptor/scaffold; Motility/polarity/chemotaxis	Q13480	2549	GAB1	4q31.21	human	Y447	PHOSPHORYLATION	449791	SEELDENyVPMNPNS		molecular association, regulation		SHP-2(INDUCES); PIK3R1(INDUCES)		685; 2532	5	2	12		
caveolin-2	Adaptor/scaffold; Motility/polarity/chemotaxis	P51636	858	CAV2	7q31.1	human	Y27	PHOSPHORYLATION	454430	SHHSGLEyADPEKFA	Caveolin	intracellular localization				4314	5	8	28		
IkB-alpha	DNA binding protein; Inhibitor protein	Q63746	25493	Nfkbia		rat	S32	PHOSPHORYLATION	448203	LVDDRHDsGLDSMKD		activity, induced; intracellular localization	apoptosis, altered; transcription, altered			1962901; 6247; 1919610	118	1	7	A S32A,S36A double mutant of IkBA inhibits the NFkB/p65-induced increase in dor (delta opiod receptor) promoter transcription; Cells expressing IKBa S32A S36A are more susceptible to apoptosis while in suspension  than cells expressing wt IKBa.	
STAT4	DNA binding protein; Transcription factor	P42228	20849	Stat4		mouse	S722	PHOSPHORYLATION	447789	PSDLLPMsPSAYAVL		activity, induced	cell differentiation, altered; transcription, altered			1284; 8832	4	1	0		
Gab1	Adaptor/scaffold; Motility/polarity/chemotaxis	Q13480	2549	GAB1	4q31.21	human	Y472	PHOSPHORYLATION	447947	EPIQEANyVPMTPGT		molecular association, regulation		SHP-2(INDUCES); PIK3R1(INDUCES)		685; 2532	6	0	2		
NR1H4 iso2	DNA binding protein; Nuclear receptor	Q96RI1-2	9971	NR1H4	12q23.1	human	T442	PHOSPHORYLATION	3333402	GRLTELRtFNHHHAE	Hormone_recep	activity, induced; intracellular localization				3309508	1	0	0		
FOXP3	C2H2-type zinc finger protein; Cell cycle regulation; DNA binding protein; Transcription factor	Q99JB6	20371	Foxp3		mouse	T175	PHOSPHORYLATION	29672100	CTFPRSGtPRKDSNL		protein degradation	cell growth, induced; transcription, altered			28722401	1	1	0	Alanine mutants inhibited (lL2) or induced (CD25) transcription of FOXP3 responsive genes, suppressed T cell proliferation, and showed an anti-inflamatory effect of  a murine colitis model.	
p53	Activator protein; DNA binding protein; Motility/polarity/chemotaxis; Nuclear receptor co-regulator; Transcription factor; Tumor suppressor	P10361	24842	Tp53		rat	S15	PHOSPHORYLATION	447490	MSIELPLsQETFSCL	P53_TAD	protein stabilization	apoptosis, induced			5659	347	2	0		
CDK4	EC 2.7.11.22; KINASE; Kinase, protein; Protein kinase, CMGC; Protein kinase, Ser/Thr (non-receptor)	P30285	12567	Cdk4		mouse	T172	PHOSPHORYLATION	448476	YSYQMALtPVVVTLW	Pkinase	enzymatic activity, induced				1007	6	2	2		
p53	Activator protein; DNA binding protein; Motility/polarity/chemotaxis; Nuclear receptor co-regulator; Transcription factor; Tumor suppressor	P02340	22059	Tp53		mouse	T18	PHOSPHORYLATION	447541	ELPLSQEtFSGLWKL	P53_TAD	activity, induced; molecular association, regulation; protein stabilization; intracellular localization	cell cycle regulation; apoptosis, altered; transcription, altered	MDM2(DISRUPTS); p300(INDUCES)		17613009; 5010603; 8057	27	0	0		
MCL1	Apoptosis; Channel, misc.; Inhibitor protein; Membrane protein, integral; Mitochondrial	P97287	17210	Mcl1		mouse	S102	PHOSPHORYLATION	1172400	SAAAAIVsPEEELDG		protein degradation; molecular association, regulation		Pin1(DISRUPTS)		1163003	4	1	0		
STI1	Chaperone	Q60864	20867	Stip1		mouse	S189	PHOSPHORYLATION	465575	LLGVDLGsMDEEEEA		intracellular localization				8653	2	0	0		
Shc1 iso2	Adaptor/scaffold; Apoptosis; Mitochondrial; Motility/polarity/chemotaxis	P98083-2	20416	Shc1		mouse	Y240	PHOSPHORYLATION	448510	EPPDHQYyNDFPGKE		activity, induced; molecular association, regulation; phosphorylation	cell motility, induced; cell motility, altered	Grb2(INDUCES)		27519622; 2195488	24	14	919	angiogenesis;  required for ErbB2- and TGFB mediated tumor metastasis to the lungs.; metastatic spread of tumors; required for migration and invasion of ERB2-expressing cells	
VEGFR2	EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Protein kinase, TK; Protein kinase, tyrosine (receptor)	P35968	3791	KDR	4q11-q12	human	Y996	PHOSPHORYLATION	447904	EEAPEDLyKDFLTLE	Pkinase_Tyr	molecular association, regulation; receptor internalization, altered; enzymatic activity, induced		PLCG1(INDUCES)		2325	5	0	0		
LPP	Adaptor/scaffold; Cytoskeletal protein; Motility/polarity/chemotaxis	Q8BFW7	210126	Lpp		mouse	Y403	PHOSPHORYLATION	3414611	HLTKKMLyDMENPPA			cell cycle regulation; cell motility, altered			2790302	0	2	10		
TACE	EC 3.4.24.86; Membrane protein, integral; Motility/polarity/chemotaxis; Protease	Q9Z0F8	11491	Adam17		mouse	T735	PHOSPHORYLATION	449804	KPFPAPQtPGRLQAL		intracellular localization				7132	11	4	2	T735A mutation induced altered localization of TACE. Wild-type TACE colocalized with calregulin an ER marker. T735E colocalizes with components of the protein secretory pathway. 	
caveolin-2	Adaptor/scaffold; Motility/polarity/chemotaxis	P51636	858	CAV2	7q31.1	human	Y19	PHOSPHORYLATION	450198	LFMDDDSySHHSGLE	Caveolin	molecular association, regulation; intracellular localization		RASA1(INDUCES); caveolin-1(INDUCES)		4314; 2882	8	7	23		
p53	Activator protein; DNA binding protein; Motility/polarity/chemotaxis; Nuclear receptor co-regulator; Transcription factor; Tumor suppressor	P04637	7157	TP53	17p13.1	human	S6	PHOSPHORYLATION	447537	__MEEPQsDPSVEPP	P53_TAD	activity, induced; acetylation; phosphorylation	apoptosis, altered; apoptosis, induced; transcription, altered			5197; 6115915; 5010605; 5004513; 5967	30	1	1		
MKK6	EC 2.7.12.2; KINASE; Kinase, protein; Protein kinase, STE; Protein kinase, dual-specificity	P52564	5608	MAP2K6	17q24.3	human	S207	ACETYLATION	4325701	ISGYLVDsVAKTIDA	Pkinase	enzymatic activity, inhibited; phosphorylation				4324302	1	0	0	yopJ inhibits MKK6 phosphorylation and its enzymatic activation in vitro	
FADD	Adaptor/scaffold; Apoptosis	Q13158	8772	FADD	11q13.3	human	S203	PHOSPHORYLATION	22496704	MSWNSDAsTSEAS__			apoptosis, induced			22463906	1	0	0	apoptosis and necrosis	
GUCY1B3	EC 4.6.1.2; Guanylyl cyclase; Lyase; Nucleotide Metabolism - purine; Receptor, misc.	Q02153	2983	GUCY1B3	4q31.3-q33	human	Y192	PHOSPHORYLATION	469612	ESKEEDFyEDLDRFE		molecular association, regulation		Src(INDUCES); Fyn(INDUCES)		8801	3	0	0		
SH3BP2	Adaptor/scaffold	Q06649	24055	Sh3bp2		mouse	Y446	PHOSPHORYLATION	449093	EEDSDEDyEKVPLPN		molecular association, regulation		Lyn(NOT_REPORTED)		2123	4	0	0		
FAK	EC 2.7.1.112; EC 2.7.10.2; KINASE; Kinase, protein; Protein kinase, TK; Protein kinase, tyrosine (non-receptor)	O35346	25614	Ptk2		rat	S722	PHOSPHORYLATION	447962	PSRPGYPsPRSSEGF		molecular association, regulation; intracellular localization				2255; 7379	7	11	0		
CTPS	EC 6.3.4.2; Ligase; Motility/polarity/chemotaxis; Nucleotide Metabolism - pyrimidine	P17812	1503	CTPS1	1p34.1	human	S462	PHOSPHORYLATION	479852	TLFQTKNsVMRKLYG	GATase	enzymatic activity, induced	cell growth, altered			11469	1	0	0		
NFAT3	DNA binding protein; Transcription factor	Q8K120	73181	Nfatc4		mouse	S676	PHOSPHORYLATION	455348	SNGRRKRsPTQSFKF	TIG	activity, induced; intracellular localization	transcription, altered			1713140	2	0	0		
EphA2	EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Protein kinase, TK; Protein kinase, tyrosine (receptor)	P29317	1969	EPHA2	1p36	human	Y588	PHOSPHORYLATION	450859	QLKPLKTyVDPHTYE		molecular association, regulation; enzymatic activity, induced	cell differentiation, altered; cell motility, altered; cell adhesion, altered	VAV2(INDUCES); VAV3(INDUCES); Nck1(INDUCES)		4254811; 7613710	3	21	628		
p21Cip1	Cell cycle regulation; Inhibitor protein	P38936	1026	CDKN1A	6p21.2	human	K163	UBIQUITINATION	9897004	RLIFSKRkP______		protein degradation; ubiquitination				5669	2	0	0	UV-induced 	
TRPC6	Channel, cation; Membrane protein, integral; Membrane protein, multi-pass	Q9Y210	7225	TRPC6	11q22.1	human	S322	PHOSPHORYLATION	3363401	KNDYKKLsMQCKDFV		activity, inhibited				12028111	4	0	0	suppresses TRPC6 channel current, G-alpha agonist-induced NFAT activation and myocyte hypertrophic responses	
PXN	Adaptor/scaffold; Cell adhesion; Cytoskeletal protein; Motility/polarity/chemotaxis	P49024	395832	PXN		chicken	S188	PHOSPHORYLATION	471382	HYVIPESsSSAGGKA	Paxillin	protein stabilization	cell motility, altered			9110	2	1	0	promotes cell spreading by increasing the dynamics of membrane protrusions	
RASA1	GTPase activating protein, Ras; Motility/polarity/chemotaxis	P09851	282032	RASA1		cow	Y457	PHOSPHORYLATION	449959	AVDGKEIyNTIRRKT		molecular association, regulation		Dok1(INDUCES)		3792	3	1	30		
NKCC2	Membrane protein, integral; Membrane protein, multi-pass; Transporter	P55015	100328575	SLC12A1		rabbit	T117	PHOSPHORYLATION	459122	KIEYYRNtGSVSGPK	AA_permease_N	activity, induced				6707	3	2	0		
ERK2	EC 2.7.11.24; KINASE; Kinase, protein; Protein kinase, CMGC; Protein kinase, Ser/Thr (non-receptor)	P63086	116590	Mapk1		rat	Y185	PHOSPHORYLATION	447594	HTGFLTEyVATRWYR	Pkinase; YukC	activity, induced; molecular association, regulation; intracellular localization; enzymatic activity, induced	cell growth, altered	MEK1(INDUCES)		6295; 4862613; 1165; 7472; 19016901; 7848; 13788306; 7910522; 5718	974	85	3953	regulate cell proliferation in dentate gyrus following ischemia; colocalized in glucose induced filipodia extensions, leading to insulin secretion	
KCC3	Membrane protein, integral; Membrane protein, multi-pass; Transporter	Q9UHW9	9990	SLC12A6	15q13	human	T1048	PHOSPHORYLATION	4770548	YQEKVHMtWTKDKYM		activity, inhibited				9985929	2	7	0		
EAR-2	DNA binding protein; Nuclear receptor	P10588	2063	NR2F6	19p13.1	human	S83	PHOSPHORYLATION	25802106	CKSFFKRsIRRNLSY	zf-C4		transcription, induced		DNA(DISRUPTS)	25785420	1	0	0		
NUMB	Cell development/differentiation; Tumor suppressor	Q2LC84	29419	Numb		rat	S294	PHOSPHORYLATION	470030	SPFKRQLsLRINELP	NumbF	molecular association, regulation		AP2A1(DISRUPTS); AP2B1(DISRUPTS); 14-3-3 eta(INDUCES)		8928	4	2	17		
amphiphysin	Vesicle protein	P49418	273	AMPH	7p14-p13	human	T387	PHOSPHORYLATION	469997	LPWDLWTtSTDLVQP		molecular association, regulation		CLTC(DISRUPTS)		8948	1	0	0		
LTB4R	GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR	Q15722	1241	LTB4R	14q11.2-q12	human	T308	PHOSPHORYLATION	455505	VAKLLEGtGSEASST		receptor desensitization, altered				5352	2	1	0		
eIF3S3	Translation; Translation initiation	O15372	8667	EIF3H	8q24.11	human	S183	PHOSPHORYLATION	471116	VCKEKDFsPEALKKA		activity, induced	cell growth, altered			4313615	1	11	2		
FOXO1A	DNA binding protein; Nuclear receptor co-regulator; Transcription factor	Q9R1E0	56458	Foxo1		mouse	S316	PHOSPHORYLATION	449113	TFRPRTSsNASTISG		intracellular localization	transcription, inhibited			4904511	20	3	18		
TBL1XR1	Nuclear receptor co-regulator; Transcription, coactivator/corepressor	Q9BZK7	79718	TBL1XR1	3q26.32	human	S204	PHOSPHORYLATION	2509600	NLSENSTsGSTQLVL			transcription, induced			2425230	1	0	0		
CDK2	EC 2.7.11.22; KINASE; Kinase, protein; Protein kinase, CMGC; Protein kinase, Ser/Thr (non-receptor)	P24941	1017	CDK2	12q13	human	Y15	PHOSPHORYLATION	447740	EKIGEGTyGVVYKAR	Pkinase	protein stabilization; enzymatic activity, inhibited; protein conformation	cell cycle regulation			2610806; 5397; 5669; 6328008; 5488; 633; 30281304; 1619; 7102	27	72	3817	required for recovery from replication stress;  loss of inhibitory phosphorylation causes DNA damage	
IRS1	Adaptor/scaffold; Motility/polarity/chemotaxis	P35568	3667	IRS1	2q36	human	S323	PHOSPHORYLATION	451399	MVGGKPGsFRVRASS		phosphorylation				1987901	11	8	0	S323A has increased DOG-uptake and increased IRS-1 pTyr in +insulin.	
desmin	Cytoskeletal protein; Motility/polarity/chemotaxis	P31001	13346	Des		mouse	S6	PHOSPHORYLATION	478272	__MSQAYsSSQRVSS			transcription, altered; cell growth, altered			9579	1	0	1	important for cardiomyogenesis	
SREBP-1 iso3	DNA binding protein; Membrane protein, integral; Membrane protein, multi-pass; Transcription factor	P36956-3	6720	SREBF1	17p11.2	human	S410	PHOSPHORYLATION	6729302	PPPSDAGsPFQSSPL		protein degradation; activity, inhibited				6331305	1	0	0		
HSPB8		Q9UJY1	26353	HSPB8	12q24.23	human	S27	PHOSPHORYLATION	7994902	PFRDSPLsSRLLDDG		protein conformation				18898712	2	0	0	decrease chaperone activity	
KCNJ12	Membrane protein, integral; Membrane protein, multi-pass	Q14500	3768	KCNJ12	17p11.2	human	T354	PHOSPHORYLATION	3053611	KTYEVPStPRCSAKD	IRK	activity, inhibited				8595	1	0	4		
Src iso2	EC 2.7.10.2; KINASE; Kinase, protein; Protein kinase, TK; Protein kinase, tyrosine (non-receptor)	NP_001020566	20779	Src		mouse	Y133	PHOSPHORYLATION	2261000	LSTGQTGyIPSNYVA	SH3_1		cell cycle regulation; cell growth, altered			2708	1	0	0		
ERK2	EC 2.7.11.24; KINASE; Kinase, protein; Protein kinase, CMGC; Protein kinase, Ser/Thr (non-receptor)	P28482	5594	MAPK1	22q11.21	human	S246	PHOSPHORYLATION	6845001	HILGILGsPSQEDLN	Pkinase	molecular association, regulation; intracellular localization		IPO7(INDUCES); NUP153(DISRUPTS)		6841100	2	0	0		
MOR-1	GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR	P42866	18390	Oprm1		mouse	S375	PHOSPHORYLATION	447784	QNTREHPsTANTVDR		receptor internalization, induced	endocytosis, induced			20726800	16	2	0	endocytosis of MOR-1	
ADRA1B	GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR	P18841		ADRA1B		hamster	S400	PHOSPHORYLATION	451003	GSLERSQsRKDSLDD		receptor desensitization, altered				3257	1	0	1		
ADCY6	Adenylyl cyclase; EC 4.6.1.1; Lyase; Membrane protein, integral; Membrane protein, multi-pass; Nucleotide Metabolism - purine	AAA40678	25289	Adcy6		rat	S750	PHOSPHORYLATION	467274	LSRSIVRsRVHSTAV		enzymatic activity, induced				8212; 8211	2	0	0		
VASP	Cytoskeletal protein; Motility/polarity/chemotaxis	P70460	22323	Vasp		mouse	S235	PHOSPHORYLATION	448380	GAKLRKVsKQEEASG		molecular association, regulation		Abl iso2(INDUCES)		5392	41	13	3		
TrkA iso2	EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Protein kinase, TK; Protein kinase, tyrosine (receptor)	P04629-2	4914	NTRK1	1q21-q22	human	Y675	PHOSPHORYLATION	447764	DIYSTDYyRVGGRTM	Pkinase_Tyr	enzymatic activity, induced				1305	9	1	8		
TNNT2	Motility/polarity/chemotaxis; Motor protein	P50752	21956	Tnnt2		mouse	T216	PHOSPHORYLATION	451556	RKSGKRQtEREKKKK	Troponin	activity, inhibited				8407	5	0	0		
CACNA1C	Channel, calcium; Membrane protein, integral; Membrane protein, multi-pass	Q13936	775	CACNA1C	12p13.3	human	S1981	PHOSPHORYLATION	455278	ASLGRRAsFHLECLK		activity, induced				22495308	21	1	0		
P130Cas	Adaptor/scaffold; Motility/polarity/chemotaxis	P56945	9564	BCAR1	16q23.1	human	Y128	PHOSPHORYLATION	448778	SKAQQGLyQVPGPSP			carcinogenesis, induced; cell motility, induced; cell growth, induced; cell adhesion, altered			25573551	3	18	775		
ADRA1B	GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR	P18841		ADRA1B		hamster	S394	PHOSPHORYLATION	451002	RPWTRGGsLERSQSR		receptor desensitization, altered				3257	1	0	0		
ER-alpha	DNA binding protein; Nuclear receptor	P03372	2099	ESR1	6q25.1	human	T311	PHOSPHORYLATION	449929	NSLALSLtADQMVSA		activity, induced; molecular association, regulation; intracellular localization	transcription, altered	NCoA2(NOT_REPORTED); SRC-1(NOT_REPORTED)		2497	6	0	0		
STAT5A	DNA binding protein; Motility/polarity/chemotaxis; Transcription factor	P42229	6776	STAT5A	17q11.2	human	S780	PHOSPHORYLATION	448750	DSLDSRLsPPAGLFT		molecular association, regulation		ERK1(DISRUPTS)		7072	9	9	0		
PKN2	EC 2.7.11.13; KINASE; Kinase, protein; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor)	Q16513	5586	PKN2	1p22.2	human	T814	PHOSPHORYLATION	3253564	GMGYGDRtSTFCGTP	Pkinase	enzymatic activity, induced				10353916	1	5	71		
KCNJ8	Channel, potassium; Membrane protein, integral; Membrane protein, multi-pass	Q63664	25472	Kcnj8		rat	S385	PHOSPHORYLATION	483976	NSLRKRNsMRRNNSM		activity, induced; activity, inhibited				8597; 1172871	3	0	0		
IRF8	DNA binding protein; Transcription factor	P23611	15900	Irf8		mouse	Y107	PHOSPHORYLATION	2299204	QLDISEPyKVYRIVP	IRF	molecular association, regulation	transcription, induced	IRF8(INDUCES); PU.1(INDUCES); IRF2(INDUCES)		9577	2	0	0		
mAChR M2	GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR	P08172	1129	CHRM2	7q31-q35	human	T310	PHOSPHORYLATION	459108	QDENTVStSLGHSKD	7tm_1	receptor desensitization, altered; receptor internalization, altered				7628	3	0	0	Mutation of 4 S/T to A eliminates receptor desensitization in response to carbachol treatment (as measured by isoproterenol-stimulated cAMP production after pretreatment with carbachol).; Mutation of S286 T287 S288 S290 to A caused a faster rate and a greater extent of receptor internalization after agonist stimulation (transients only, not observed in stables).  Mutation of all 8 sites prevented internalization (in both transients and stables).	
p63	DNA binding protein; Transcription factor	Q9H3D4	8626	TP63	3q28	human	S477	PHOSPHORYLATION	7643500	NSMNKLPsVSQLINP		protein degradation				7543532	1	0	0	DLX3-mediated degradation	
STAT5B	DNA binding protein; Transcription factor	P52632	25126	Stat5b		rat	Y679	PHOSPHORYLATION	449034	DRPKDEVySKYYTPV		intracellular localization	transcription, altered			2065	1	0	0		
ERK1	EC 2.7.1.123; EC 2.7.11.24; KINASE; Kinase, protein; Protein kinase, CMGC; Protein kinase, Ser/Thr (non-receptor)	P27361	5595	MAPK3	16p11.2	human	T202	PHOSPHORYLATION	447542	HDHTGFLtEYVATRW	Pkinase; YukC	activity, induced; protein degradation; molecular association, regulation; intracellular localization; protein conformation; phosphorylation; enzymatic activity, induced	cell motility, induced; cell differentiation, induced; cell motility, altered; cytoskeletal reorganization; transcription, inhibited; cell growth, altered	TACE(INDUCES); KSR(INDUCES)		30280005; 7397603; 5487; 902; 7119508; 4313628; 7674; 6121900; 3406; 7483320; 5884; 899; 11975; 13354722; 6011114; 7839; 13872500; 5708; 3394329; 6926; 25725907; 7550825; 668; 4914001; 3342623; 3394311; 5930044; 1172804	994	51	1957	 increase of RhoA and Cdc42 activity, motility, migration, and invasion	
Kit	EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Protein kinase, TK; Protein kinase, tyrosine (receptor)	P10721	3815	KIT	4q11-q12	human	S741	PHOSPHORYLATION	450035	TKADKRRsVRIGSYI	Pkinase_Tyr	enzymatic activity, inhibited; phosphorylation				2598	1	0	0		
SNAP-25	Vesicle protein	P60879	20614	Snap25		mouse	S187	PHOSPHORYLATION	448668	RIMEKADsNKTRIDE	Exonuc_VII_L; SNARE	activity, inhibited	exocytosis, altered			8820; 1968316	12	0	0		
AFAP1L2	Activator protein; Cell cycle regulation	Q8N4X5	84632	AFAP1L2	10q25.3	human	Y54	PHOSPHORYLATION	462131	SSSSDEEyIYMNKVT		molecular association, regulation		PIK3R1(INDUCES)		5930017	1	3	175		
Myb	DNA binding protein; Transcription factor	P06876	17863	Myb		mouse	T572	PHOSPHORYLATION	1308922	LTSSVLMtPVSEDED		protein degradation; ubiquitination				1172847; 17431534; 7890603	3	0	0		
DARPP-32	Motility/polarity/chemotaxis; Protein phosphatase, regulatory subunit	Q60829	19049	Ppp1r1b		mouse	T75	PHOSPHORYLATION	448048	RPNPCAYtPPSLKAV	DARPP-32; PPP4R2; Nop14	activity, induced; enzymatic activity, induced				6780; 2706604; 6256	26	4	16	Phosphorylation of S566 is necessary for PP2A enzymatic activation and dephosphorylation of DARPP.; Mutation of T75 impaired a specific behavioral response (locomotor sensitization) to repeated cocaine administration.	
CACNB2	Channel, calcium	Q8VGC3	116600	Cacnb2		rat	S530	PHOSPHORYLATION	451474	KSQHRSSsATHQNHR		activity, induced				10274622	4	0	0		
CD19	Cell surface; Membrane protein, integral	P15391	930	CD19	16p11.2	human	Y348	PHOSPHORYLATION	454081	GSGPQNQyGNVLSLP		activity, induced; molecular association, regulation		SOS1(INDUCES); Grb2(INDUCES)		8326	1	1	17		
PIK3R1	Enzyme, regulatory subunit; KINASE; Kinase, lipid; Motility/polarity/chemotaxis	P23727	282307	PIK3R1		cow	Y688	PHOSPHORYLATION	448137	FAEPYNLySSLKELV	SH2	molecular association, regulation		PIK3R1(INDUCES)		1234	3	0	0	phosphorylation of this site increases activity of PI3K lipid kinase and modulates transcription through NFkB	
JAK2	EC 2.7.10.2; KINASE; Kinase, protein; Protein kinase, TK; Protein kinase, tyrosine (non-receptor)	O60674	3717	JAK2	9p24	human	Y813	PHOSPHORYLATION	451492	NSLFTPDyELLTEND		molecular association, regulation; phosphorylation		SH2-B-beta(INDUCES); APS(INDUCES)		6114; 3361007; 2531308	7	2	2	JAK2 Y1007/8 phosphorylation	
Mnk1 iso2	EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, CAMK; Protein kinase, Ser/Thr (non-receptor); Translation	Q9BUB5-2	8569	MKNK1	1p33	human	T209	PHOSPHORYLATION	447621	NSCTPITtPELTTPC	Pkinase	intracellular localization; enzymatic activity, induced				762706	11	0	1	Leaves nucleus to cytoplasm upon phosphorylation.	
GATA1	DNA binding protein; Transcription factor	P15976	2623	GATA1	Xp11.23	human	S26	PHOSPHORYLATION	451232	VDPALVSsTPESGVF		activity, induced	transcription, induced			14058626	5	0	0	enhances survivin expression	
MAPKAPK5	EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, CAMK; Protein kinase, Ser/Thr (non-receptor)	Q8IW41	8550	MAPKAPK5	12q24.13	human	T182	PHOSPHORYLATION	450093	IDQGDLMtPQFTPYY	Pkinase	enzymatic activity, induced	cell growth, altered			2665608; 18668008	6	3	69		
BARD1	EC 6.3.2.-; EC 6.3.2.19; Ligase; Tumor suppressor; UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase	Q99728	580	BARD1	2q34-q35	human	S184	PHOSPHORYLATION	455771	QDSYEFVsPSPPADV			cell cycle regulation			5849	1	1	0	resistance to genotoxic stress (mitomycin C)	
Nlp	Cell cycle regulation; Microtubule binding protein	Q9Y2I6	22981	NINL	20p11.22-p11.1	human	S185	PHOSPHORYLATION	15668109	WDSEDFGsPQKSCSP		protein degradation; molecular association, regulation; protein stabilization; ubiquitination; intracellular localization	cell cycle regulation	PLK1(INDUCES)		17482929; 15562527	2	0	0		
calmodulin	Calcium-binding protein	P62161	24242	Calm1		rat	S82	PHOSPHORYLATION	448705	RKMKDTDsEEEIREA	DUF2267; DUF1103; LNS2; TerB; Tenui_NCP	activity, inhibited; phosphorylation				1876; 3087	5	6	0		
EHHADH	Amino Acid Metabolism - lysine degradation; Amino Acid Metabolism - tryptophan; Amino Acid Metabolism - valine, leucine and isoleucine degradation; Carbohydrate Metabolism - butanoate; Carbohydrate Metabolism - propanoate; EC 1.1.1.35; EC 4.2.1.17; EC 5.3.3.8; Isomerase; Lipid Metabolism - fatty acid; Lyase; Mitochondrial; Other Amino Acids Metabolism - beta-alanine; Oxidoreductase; Secondary Metabolites Metabolism - limonene and pinene degradation	Q08426	1962	EHHADH	3q26.3-q28	human	K346	ACETYLATION	461836	MITSVLEkEASKMQQ	3HCDH_N	enzymatic activity, induced				12513600	0	3	3		
SYN1	Vesicle protein	P17599	281510	SYN1		cow	Y301	PHOSPHORYLATION	478277	VVALTKTyATTEPFI	Synapsin_C	molecular association, regulation		SYN1(INDUCES)		14784600	2	0	2	increases SYN1 oligomerization 	
eEF2K	EC 2.7.11.20; KINASE; Kinase, protein; Protein kinase, ATYPICAL; Protein kinase, Ser/Thr (non-receptor); Translation	O00418	29904	EEF2K	16p12.2	human	S445	PHOSPHORYLATION	483529	SGDSGYPsEKRGELD		protein degradation; molecular association, regulation; ubiquitination		BRD8(INDUCES)		25573527	3	10	7		
CACNA1C	Channel, calcium; Membrane protein, integral; Membrane protein, multi-pass	P22002	24239	Cacna1c		rat	S1927	PHOSPHORYLATION	455278	ASLGRRAsFHLECLK		activity, induced; molecular association, regulation; activity, inhibited		PPP2CA(INDUCES); ITGB1(INDUCES)		17675039; 7729; 7779; 12229; 9721224	21	1	0		
CBP	ACETYLTRANSFERASE; Acetyltransferase; DNA binding protein; EC 2.3.1.48; Motility/polarity/chemotaxis; Nuclear receptor co-regulator; Transcription, coactivator/corepressor	P45481	12914	Crebbp		mouse	S2015	PHOSPHORYLATION	455574	QVSGPVMsSMPPGQW			transcription, induced			4471	1	0	0		
IKKB	EC 2.7.11.10; KINASE; Kinase, protein; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor)	O88351	16150	Ikbkb		mouse	S682	PHOSPHORYLATION	17934901	SMNVSRLsHPGQLMS		molecular association, regulation; phosphorylation		PPP2R3C(INDUCES)		17675011	1	0	0	interaction with PPP2R3C (aka G4-1) downregulates IKK-beta activity;  S181 phosphorylation increased in S679/682/689/692/697/701/705A mutant	
IKKB	EC 2.7.11.10; KINASE; Kinase, protein; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor)	O14920	3551	IKBKB	8p11.2	human	S750	PHOSPHORYLATION	5014910	QTEEEEHsCLEQAS_		molecular association, regulation		IKK-gamma(DISRUPTS)		5007912	2	0	0		
p53	Activator protein; DNA binding protein; Motility/polarity/chemotaxis; Nuclear receptor co-regulator; Transcription factor; Tumor suppressor	P04637	7157	TP53	17p13.1	human	K370	ACETYLATION	458981	RAHSSHLkSKKGQST			apoptosis, induced; transcription, altered			2790309; 7647800	15	3	0	 ; ZNF420 (Apak) represses p53 activity by attenuating its acetylation ;  p53 8KR mutant can be still degraded by Mdm2; p53 8KR mutation (K120/164/370/372/373/381/382/386R) impairs p53-dependent transcription	
PKCA	EC 2.7.11.13; KINASE; Kinase, protein; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor)	P04409	282001	PRKCA		cow	T497	PHOSPHORYLATION	448598	MDGVTTRtFCGTPDY	Pkinase	enzymatic activity, induced				1238; 1884	6	25	42		
caldesmon	Actin binding protein	Q05682	800	CALD1	7q33	human	S714	PHOSPHORYLATION	456706	EGVRNIKsMWEKGNV	Caldesmon		cell motility, altered; cytoskeletal reorganization			12778807; 8076	5	0	0		
PLD2	EC 3.1.4.4; Lipid Metabolism - ether lipid; Lipid Metabolism - glycerophospholipid; Motility/polarity/chemotaxis; Phospholipase	P97813	18806	Pld2		mouse	Y11	PHOSPHORYLATION	450938	TQKNLFPyGDYLNSS		molecular association, regulation; intracellular localization; phosphorylation; enzymatic activity, induced		EGFR(NOT_REPORTED)		4130; 3169	2	0	1		
GR	DNA binding protein; Mitochondrial; Nuclear receptor; Transcription factor	P04150	2908	NR3C1	5q31.3	human	S404	PHOSPHORYLATION	5044100	SMRPDVSsPPSSSST		protein degradation; molecular association, regulation; intracellular localization; protein conformation; activity, inhibited	apoptosis, inhibited; transcription, induced	NFkB-p65(DISRUPTS); p300(INDUCES)		5007905	1	2	1	404A mutant repressed many genes induced by WT, but overall induced more genes than WT.	
TH iso2	Amino Acid Metabolism - tyrosine; EC 1.14.16.2; Endoplasmic reticulum; Mitochondrial; Oxidoreductase; Vesicle protein	P07101-2	7054	TH	11p15.5	human	S67	PHOSPHORYLATION	448545	RFIGRRQsLIEDARK	TOH_N	enzymatic activity, induced				7484	46	6	11		
Srcasm	Adaptor/scaffold	O75674	10040	TOM1L1	17q23.2	human	Y460	PHOSPHORYLATION	451210	AVTTEAIyEEIDAHQ		molecular association, regulation; intracellular localization	endocytosis, altered	EGFR(INDUCES); Grb2(INDUCES)		10353937	2	1	33	regulates EGF-stimulated endocytosis of EGFR	
H3	DNA binding protein	P68433	360198	Hist1h3a		mouse	S29	PHOSPHORYLATION	455677	ATKAARKsAPATGGV		molecular association, regulation	chromatin organization, altered; transcription, induced; transcription, altered; cell growth, altered	14-3-3 zeta(INDUCES); 14-3-3 epsilon(INDUCES)	DNA(INDUCES)	4260501; 21328604; 15031328	38	6	0	S29 phosphorylation increases  occupancy of Brf1 and TBP promoters.	
BRAF	EC 2.7.1.37; EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, Ser/Thr (non-receptor); Protein kinase, TKL	P15056	673	BRAF	7q34	human	S429	PHOSPHORYLATION	447803	PQRERKSsSSSEDRN		enzymatic activity, inhibited	transcription, altered; cell growth, altered			4264910; 1748; 6588	6	0	32		
Borealin	Cell cycle regulation	Q53HL2	55143	CDCA8	1p34.3	human	T88	PHOSPHORYLATION	4203203	QALEEAAtADLDITE			cell cycle regulation; cytoskeletal reorganization			4201803	2	0	0	chromosome alignment in mitosis	
gephyrin	Adaptor/scaffold; EC 2.10.1.1; EC 2.7.7.75	Q8BUV3	268566	Gphn		mouse	S200	PHOSPHORYLATION	478374	LSPPPTTsPHKQTED		molecular association, regulation		Pin1(INDUCES)		9631	2	6	0		
caldesmon	Actin binding protein	P12957	373965	CALD1		chicken	T627	PHOSPHORYLATION	15668101	GMKPAHTtAVVSKID	Caldesmon	molecular association, regulation		caldesmon(DISRUPTS)		15571612	0	1	0	enhances effect of S672 and S702  phosphorylation to weaken interaction	
ROCK2	EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor)	Q28021	282041	ROCK2		cow	T967	PHOSPHORYLATION	1732201	ELTEKDAtIASLEET		enzymatic activity, induced	cell cycle regulation			12177	1	0	0	alanine mutation of all 4 sites	
CDH5	Cell adhesion; Membrane protein, integral; Motility/polarity/chemotaxis	P33151	1003	CDH5	16q22.1	human	Y658	PHOSPHORYLATION	456048	GEMDTTSyDVSVLNS	Cadherin_C	molecular association, regulation	cell motility, altered; cell adhesion, altered; signaling pathway regulation	CTNND1(DISRUPTS)		18378506; 6644	5	0	0	 regulates Rac1 activity; regulation at cell-cell junctions	
IKK-gamma	Adaptor/scaffold; Protein kinase, regulatory subunit	O88522	16151	Ikbkg		mouse	S85	PHOSPHORYLATION	458399	ELLHFQVsQREEKEF	NEMO; Filament	activity, induced				19075406	4	0	0	TAK1 activation	
TAO1	EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, STE; Protein kinase, Ser/Thr (non-receptor)	Q7L7X3	57551	TAOK1	17q11.2	human	T502	PHOSPHORYLATION	3627514	RLDKDLEtQRNNFAA		activity, induced	cell cycle regulation			12287	1	0	0		
LRRK2	EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, Ser/Thr (non-receptor); Protein kinase, TKL	Q5S007	120892	LRRK2	12q12	human	T2035	PHOSPHORYLATION	477192	GIKTSEGtPGFRAPE	Pkinase	enzymatic activity, induced				15022711	4	1	0		
CLK2	EC 2.7.12.1; KINASE; Kinase, protein; Protein kinase, CMGC; Protein kinase, dual-specificity	O35491	12748	Clk2		mouse	Y99	PHOSPHORYLATION	26375902	DTDFRQSyEYHRENS		protein degradation				25779410	1	0	0		
TAK1	EC 2.7.11.25; KINASE; Kinase, protein; Protein kinase, Ser/Thr (non-receptor); Protein kinase, TKL	Q62073	26409	Map3k7		mouse	S412	PHOSPHORYLATION	455196	NGQPRRRsIQDLTVT		phosphorylation	cell differentiation, altered; transcription, altered			4396	2	37	61		
ADRB2	GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR	P04274	101836719	Adrb2		hamster	Y364	PHOSPHORYLATION	449810	NSNGKTDyMGEASGC		activity, induced				3455	5	0	0		
AYTL1	ACETYLTRANSFERASE; Acetyltransferase; EC 2.3.1.-; EC 2.3.1.23; EC 2.3.1.67; Membrane protein, integral	Q8BYI6	270084	Lpcat2		mouse	S34	PHOSPHORYLATION	15146101	PMVPRQAsFFPPPVP		enzymatic activity, induced				15022730	1	1	0		
SCN2A	Channel, sodium; Membrane protein, integral; Membrane protein, multi-pass	P04775	24766	Scn2a		rat	S687	PHOSPHORYLATION	451194	EIRKRRSsSYHVSMD	DUF3451	activity, induced				8665	3	2	0		
TOP2A	EC 5.99.1.3; Isomerase	P11388	7153	TOP2A	17q21-q22	human	S1337	PHOSPHORYLATION	477804	LDSDEDFsDFDEKTD		intracellular localization; enzymatic activity, induced	cell cycle regulation; apoptosis, induced			2425238	1	21	16	required for normal sister chromatid segregationi late mitosis	
ERK5	EC 2.7.11.24; KINASE; Kinase, protein; Protein kinase, CMGC; Protein kinase, Ser/Thr (non-receptor)	Q9WVS8	23939	Mapk7		mouse	S766	PHOSPHORYLATION	14561005	DSASLSAsLLADWLE			transcription, altered			14551427	1	1	0		
vimentin	Cytoskeletal protein; Motility/polarity/chemotaxis	P08670	7431	VIM	10p13	human	S39	PHOSPHORYLATION	451766	TTSTRTYsLGSALRP	Filament_head; DUF2464	protein stabilization; molecular association, regulation; phosphorylation	carcinogenesis, altered; cell motility, altered; cytoskeletal reorganization	vimentin(DISRUPTS)		18021031; 7549203; 7571; 2214	16	24	28		
eNOS	Amino Acid Metabolism - arginine and proline; EC 1.14.13.39; Oxidoreductase	P29473	287024	NOS3		cow	S635	PHOSPHORYLATION	448637	WRRKRKEsSNTDSAG	Flavodoxin_1	acetylation; phosphorylation; enzymatic activity, induced				14825601; 3256102; 5695; 1834	22	5	1		
IRAK1BP1	Transcription regulation	Q9ESJ7	65099	Irak1bp1		mouse	S241	PHOSPHORYLATION	12524609	SATIHAAsKVFITFE	SIMPL	intracellular localization	transcription, altered			12482402	1	0	0	nuclear localization	
FAM125A	Adaptor/scaffold	Q96EY5	93343	FAM125A	19p13.11	human	S170	PHOSPHORYLATION	3208938	SRDMQGLsLDAASQP	DUF2464	protein processing				12660601	1	16	0	inhibition of HIV-1 release and infectivity	
PXR	DNA binding protein; Nuclear receptor	O75469	8856	NR1I2	3q12-q13.3	human	S305	PHOSPHORYLATION	9730702	TWECGRLsYCLEDTA	Hormone_recep	molecular association, regulation	transcription, altered	N-CoR1(INDUCES); Fgr(DISRUPTS); RXRA(DISRUPTS)		9689411	2	0	0	inhibits transcription	
AS160	GTPase activating protein, Rab	O60343	9882	TBC1D4	13q22.2	human	T568	PHOSPHORYLATION	486326	NKAKRSLtSSLENIF		molecular association, regulation		14-3-3 epsilon(INDUCES)		14058615	2	6	14	multiple sites (6P) mutant	
moesin	Cytoskeletal protein; Motility/polarity/chemotaxis	P26038	4478	MSN	Xq11.1	human	T558	PHOSPHORYLATION	447706	LGRDKYKtLRQIRQG	ERM		cell motility, altered; cytoskeletal reorganization			7318602; 7313800	27	3	27		
P2X7	Channel, ligand-gated; Membrane protein, integral; Membrane protein, multi-pass; Receptor, misc.	Q64663	29665	P2rx7		rat	Y343	PHOSPHORYLATION	450310	YIGSTLSyFGLATVC	P2X_receptor; TM	activity, induced	cytoskeletal reorganization			2925	1	0	0		
GNB1	G protein; G protein, heterotrimeric; G protein, heterotrimeric beta WD	P62873	2782	GNB1	1p36.33	human	H266	PHOSPHORYLATION	9643001	QELMTYShDNIICGI	WD40	activity, induced				8049901	3	0	0		
KCC2	Membrane protein, integral; Membrane protein, multi-pass; Transporter	Q63633	171373	Slc12a5		rat	Y926	PHOSPHORYLATION	14932400	SDISAYTyEKTLVME		protein degradation				14790321	1	0	0	decreases the cell surface stability of SLC12A5 (aka KCC2)	
PLK4	EC 2.7.11.21; KINASE; Kinase, protein; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor)	Q64702	20873	Plk4		mouse	S301	PHOSPHORYLATION	12654009	ITASSGTsLSGSLLD		protein degradation; ubiquitination				12525201	1	1	0		
Cdc25A	EC 3.1.3.48; Motility/polarity/chemotaxis; PHOSPHATASE; Protein phosphatase, dual-specificity	P30304	993	CDC25A	3p21	human	T80	PHOSPHORYLATION	4209300	RMGSSEStDSGFCLD		protein degradation; molecular association, regulation; ubiquitination; phosphorylation		GSK3B(INDUCES)		4207603	2	0	0		
PKCE	EC 2.7.11.13; KINASE; Kinase, protein; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor)	P16054	18754	Prkce		mouse	S729	PHOSPHORYLATION	448789	QEEFKGFsYFGEDLM	Pkinase_C	intracellular localization; enzymatic activity, induced				2654; 14664303; 2207	15	9	5	PLKCE phosphorylated at S729, has Golgi-perinuclear localization and is increased in differetiated C2C12 cells.   	
p90RSK	EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor); Translation	Q63531	81771	Rps6ka1		rat	T573	PHOSPHORYLATION	447993	AENGLLMtPCYTANF	Pkinase	activity, induced				849	13	7	169		
DGKD	EC 2.7.1.107; Kinase, lipid; Lipid Metabolism - glycerolipid; Lipid Metabolism - glycerophospholipid; Motility/polarity/chemotaxis	Q16760	8527	DGKD	2q37.1	human	S70	PHOSPHORYLATION	452138	QNNSFQRsKRRYFKL	PH	intracellular localization				4064	1	0	0	Phosphorylation appears to disrupt translocation of DAGK to the plasma membrane.	
CLCN1	Channel, chloride; Membrane protein, integral; Membrane protein, multi-pass	P35523	1180	CLCN1	7q35	human	S892	PHOSPHORYLATION	14645302	ASFRNTTsTRKSTGA		activity, induced				14551407	1	0	1		
CDH2	Cell adhesion; Membrane protein, integral; Motility/polarity/chemotaxis	P19022	1000	CDH2	18q11.2	human	Y860	PHOSPHORYLATION	458305	DSLLVFDyEGSGSTA	Cadherin_C	molecular association, regulation		CTNNB1(DISRUPTS)		7396	1	0	0		
STAT5A	DNA binding protein; Motility/polarity/chemotaxis; Transcription factor	P42231	443419	STAT5A		sheep	Y694	PHOSPHORYLATION	447767	LAKAVDGyVKPQIKQ		activity, induced	transcription, altered			796	88	24	2145		
RelB	Transcription factor	Q04863	19698	Relb		mouse	S552	PHOSPHORYLATION	450233	AFGGGLLsPGPEAT_		protein degradation				1822	2	7	1		
HIPK2	EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, CMGC; Protein kinase, Ser/Thr (non-receptor)	Q9H2X6	28996	HIPK2	7q32-q34	human	K565	UBIQUITINATION	3059906	YDTVNQSkTPFITHV		protein degradation				2831762	1	0	0		
geminin	Cell cycle regulation; Motility/polarity/chemotaxis	O75496	51053	GMNN	6p22.3	human	S201	PHOSPHORYLATION	475943	CAEGTVSsSTDAKPC	Fmp27_WPPW		apoptosis, altered			9237	1	0	0	regulates geminin cleavage by caspase-3	
SPAG5	Cell cycle regulation	Q7TME2	54141	Spag5		mouse	S447	PHOSPHORYLATION	11270700	SSTQTDSsPCGVTKT			cell cycle regulation			11270013	1	0	0	T24/66/447A mutant impairs meiosis progression	
RIPK2	EC 2.7.10.2; EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, Ser/Thr (non-receptor); Protein kinase, TKL	O43353	8767	RIPK2	8q21	human	Y474	PHOSPHORYLATION	4270705	DLIMKEDyELVSTKP	CARD	protein degradation; molecular association, regulation; ubiquitination; enzymatic activity, induced		NOD2(INDUCES)		17675054	1	1	0		
TIF1B	EC 6.3.2.-; KINASE; Kinase, protein; Ligase; Nuclear receptor co-regulator; Protein kinase, ATYPICAL; Protein kinase, atypical; Transcription, coactivator/corepressor; UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase	Q13263	10155	TRIM28	19q13.4	human	S824	PHOSPHORYLATION	460839	LPGAGLSsQELSGGP		sumoylation	DNA repair, induced; chromatin organization, altered; transcription, induced			25227625; 14058627; 27959900; 8142	18	6	6	involved in DNA damage response	
Ret	EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Protein kinase, TK; Protein kinase, tyrosine (receptor)	P07949	5979	RET	10q11.2	human	Y905	PHOSPHORYLATION	447627	DVYEEDSyVKRSQGR	Pkinase_Tyr	enzymatic activity, induced; phosphorylation	cell growth, altered			12482277; 3433; 778; 8770; 1261; 3073; 8773	11	3	20	Transgenic mice expressing Ret Y905A, Y1005A or Y1062A had tumor formation rates significantlly lower than WT Ret/PTC1mice.	
DAT	Membrane protein, integral; Membrane protein, multi-pass; Transporter	Q01959	6531	SLC6A3	5p15.3	human	S7	PHOSPHORYLATION	451136	_MSKSKCsVGLMSSV		activity, induced				3338; 8183	4	1	1	stimulates DAT-mediated efflux of dopamine	
Bim	Apoptosis	O54918	12125	Bcl2l11		mouse	S100	PHOSPHORYLATION	449602	FSFDTDRsPAPMSCD		molecular association, regulation	apoptosis, altered	Bax(DISRUPTS)		4230	8	1	0		
Casp2	Apoptosis; EC 3.4.22.-; EC 3.4.22.55; Protease	P42575	835	CASP2	7q34-q35	human	S139	PHOSPHORYLATION	6835500	LSCDYDLsLPFPVCE		protein processing; enzymatic activity, induced	cell cycle regulation			6829204	1	1	0		
Huntingtin	Cytoskeletal protein	P42859	15194	Htt		mouse	S1159	PHOSPHORYLATION	465621	LTNPPSLsPIRRKGK			apoptosis, inhibited			12086	2	4	12		
AML3	DNA binding protein; Transcription factor	Q13950	860	RUNX2	6p21	human	S340	PHOSPHORYLATION	4169883	TDVPRRIsDDDTATS			transcription, altered			7324302	2	4	0		
MARK2	EC 2.7.11.1; EC 2.7.11.26; KINASE; Kinase, protein; Protein kinase, CAMK; Protein kinase, Ser/Thr (non-receptor)	CAB06295	60328	Mark2		rat	S212	PHOSPHORYLATION	450068	KLDTFCGsPPYAAPE	Pkinase	enzymatic activity, inhibited; enzymatic activity, induced				1871103; 2550; 6889	5	6	10		
hnRNP I	RNA binding protein; RNA splicing	P26599	5725	PTBP1	19p13.3	human	S16	PHOSPHORYLATION	450288	AVGTKRGsDELFSTC		intracellular localization				2930	1	5	0		
G-alpha(13)	G protein; G protein, heterotrimeric; G protein, heterotrimeric alpha G(12)	Q14344	10672	GNA13	17q24.3	human	T203	PHOSPHORYLATION	448723	ILLARRPtKGIHEYD	G-alpha	molecular association, regulation		TXA2-R iso2(INDUCES)		5838	1	0	1		
IRS1	Adaptor/scaffold; Motility/polarity/chemotaxis	P35570	25467	Irs1		rat	Y1172	PHOSPHORYLATION	451288	GLEKSLNyIDLDLVK		molecular association, regulation		SHP-2(INDUCES); Grb2(INDUCES)		7397638; 3512	3	5	20		
PELI1	Adaptor/scaffold; EC 6.3.2.-; EC 6.3.2.19; Ligase; UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase	Q96FA3	57162	PELI1	2p13.3	human	S293	PHOSPHORYLATION	7388014	FNTLAFPsMKRKDVV	Pellino; zf-RING_2	ubiquitination; enzymatic activity, induced				7228504	2	0	4		
MYPT1	Motility/polarity/chemotaxis; Protein phosphatase, regulatory subunit	O14974	4659	PPP1R12A	12q15-q21	human	S445	PHOSPHORYLATION	452077	LGLRKTGsYGALAEI		molecular association, regulation	cell adhesion, altered	14-3-3 beta(INDUCES)		14148621	2	31	62		
ARFIP1	G protein regulator, misc.	P53367	27236	ARFIP1	4q31.3	human	S132	PHOSPHORYLATION	3191827	LELVRKWsLNTYKCT	Arfaptin	molecular association, regulation; intracellular localization		ARF1(DISRUPTS)		26341746	2	13	35	regulates insulin secretion	
PDX1	DNA binding protein; Transcription factor	P52945	3651	PDX1	13q12.1	human	S61	PHOSPHORYLATION	458401	LGALEQGsPPDISPY			transcription, induced			8116	3	0	0		
P70S6KB	EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor); Translation	Q9Z1M4	58988	Rps6kb2		mouse	S417	PHOSPHORYLATION	455990	SPRRLNSsPRTPISP		phosphorylation				1172822	2	3	11		
RFA2	DNA replication	P15927	6118	RPA2	1p35	human	T21	PHOSPHORYLATION	448340	YGGAGGYtQSPGGFG		intracellular localization; phosphorylation	cell cycle regulation; apoptosis, altered; cell growth, altered			9980423; 11270029; 9042	12	0	0		
GYS1	Carbohydrate Metabolism - starch and sucrose; EC 2.4.1.11; Transferase	P13807	2997	GYS1	19q13.3	human	S11	PHOSPHORYLATION	451605	NRTLSMSsLPGLEDW		enzymatic activity, inhibited				7543506	9	1	1		
PKD1	Autophagy; EC 2.7.11.13; KINASE; Kinase, protein; Motility/polarity/chemotaxis; Protein kinase, CAMK; Protein kinase, Ser/Thr (non-receptor)	Q62101	18760	Prkd1		mouse	S203	PHOSPHORYLATION	449896	GVRRRRLsNVSLTGL		enzymatic activity, induced				2387	5	20	58		
PHLPP	EC 3.1.3.16; PHOSPHATASE; Protein phosphatase, Ser/Thr (non-receptor)	O60346	23239	PHLPP1	18q21.33	human	S1359	PHOSPHORYLATION	22769300	VPRPHVQsVLLTPQD	PP2C	protein degradation				22767400	1	1	0	PHLPP phosphorylation induces degradation and Akt1 activation negatively regulates degradation. 	
tau iso8	Cytoskeletal protein	P10636-8	4137	MAPT	17q21.1	human	T212	PHOSPHORYLATION	447934	TPGSRSRtPSLPTPP		O-GlcNAc glycosylation; molecular association, regulation; intracellular localization; protein processing; protein conformation	apoptosis, altered; cytoskeletal reorganization	WWOX(INDUCES); TUBA1A(INDUCES); Pin1(INDUCES)		4578; 5955610; 6708; 2587205; 8165400; 5955609; 6115906; 17630402; 15331007	31	11	5	hyperphosphorylation of this site decreases O-GlcNAcylation of tau ; decreases rate of microtubule assembly; Phosphotylated sites found in the somato-dendritic campartment but not in the axon, where tau was not phosphorylated (T205 and T217),  or not simultaneously phosphorylated (T231 and 235). ; induced tau aggregation on microtubule networks; Pseudophosphorylation mutants S199E, T212E, S214E, double mutant T212E/S214E, and triple mutant S199E/202E/T205E showed increased filament mass at equilibrium in vitro, as compared to WT tau. S212E mutant showed longer filament lengths compared to WT in vitro.; induced  tau-tau association and formed aggregates in cell nucleus	
Fe65	Adaptor/scaffold; Apoptosis; Transcription regulation	O00213	322	APBB1	11p15	human	Y547	PHOSPHORYLATION	451143	VQKFQVYyLGNVPVA	PID	molecular association, regulation	transcription, induced	RASD1(DISRUPTS)		5007906	2	1	0	part of a tripartite complex with APP	
H2AX	DNA binding protein; Helicase	P16104	3014	H2AFX	11q23.3	human	S140	PHOSPHORYLATION	448841	GKKATQAsQEY____		molecular association, regulation; intracellular localization	cell cycle regulation; apoptosis, altered; DNA repair, altered; cytoskeletal reorganization	MDC1(INDUCES); NBS1(INDUCES); H1B(DISRUPTS); PARP1(INDUCES); Rad50(INDUCES); 53BP1(INDUCES)		6011122; 2778; 6702307; 22495302; 14148619; 15331031; 4317106; 17613003; 1903003; 18378512; 2009	149	14	17		
IKKB	EC 2.7.11.10; KINASE; Kinase, protein; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor)	O88351	16150	Ikbkb		mouse	Y199	PHOSPHORYLATION	449633	ELLEQQKyTVTVDYW	Pkinase	enzymatic activity, induced	cell differentiation, induced			22881913	4	0	0	osteoclast differentiation	
caldesmon	Actin binding protein	P12957	373965	CALD1		chicken	S642	PHOSPHORYLATION	15668102	SRLEQYTsAVVGNKA	Caldesmon	molecular association, regulation		caldesmon(DISRUPTS)		15571612	0	1	1	enhances effect of S672 and S702  phosphorylation to weaken interaction	
PGAM1	Carbohydrate Metabolism - glycolysis and gluconeogenesis; EC 3.1.3.13; EC 5.4.2.1; EC 5.4.2.4; Isomerase; Phosphatase (non-protein)	P18669	5223	PGAM1	10q25.3	human	S118	PHOSPHORYLATION	455497	QVKIWRRsYDVPPPP	His_Phos_1	enzymatic activity, inhibited				5340	1	21	3		
hnRNP C1/C2	RNA binding protein; RNA splicing; Spliceosome	P07910	3183	HNRNPC	14q11.2	human	S299	PHOSPHORYLATION	448834	EGEDDRDsANGEDDS	RP-C_C	molecular association, regulation			RNA(NOT_REPORTED)	4574	3	33	87		
CEACAM1	Cell adhesion; Immunoglobulin superfamily; Membrane protein, integral; Motility/polarity/chemotaxis	P31809	26365	Ceacam1		mouse	Y515	PHOSPHORYLATION	451429	PRATETVySEVKKK_		intracellular localization				3630	2	0	37		
Huntingtin	Cytoskeletal protein	P51111	29424	Htt		rat	S1150	PHOSPHORYLATION	465621	LTNPPSLsPIRRKGK			apoptosis, inhibited			12086	2	4	12	regulates neuronal death through a p53-dependent pathway	
TAO1	EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, STE; Protein kinase, Ser/Thr (non-receptor)	Q7L7X3	57551	TAOK1	17q11.2	human	T785	PHOSPHORYLATION	3627516	SINEMLStQALRLDE		activity, induced	cell cycle regulation			12287	1	0	0		
Kv7.3 iso2	Channel, potassium; Membrane protein, integral; Membrane protein, multi-pass	O88944-2	29682	Kcnq3		rat	Y349	PHOSPHORYLATION	453409	IQAAWRYyATNPNRL		activity, inhibited				4129	1	0	0	inhibition of  K(+) current via reducing open probability.	
AP2M1	Adaptor/scaffold; Vesicle protein	P53679	116563	Ap2m1		rat	T156	PHOSPHORYLATION	448782	SQITSQVtGQIGWRR		molecular association, regulation; intracellular localization; protein conformation		TGOLN2(INDUCES)		1941; 6199	4	14	25	T156A mutants are defective in the endocytosis of labelled transferrin.  Although the paper demonstrates a functional correlation between T156 and endocytosis, it does not directly prove that this effect is due to phosphorylation.; increased binding to Yxx(hydrophobic) peptides such as TGOLN2 sorting signal (DYQRLN) and to phospholipids (PtdIns4,5P2-containing liposomes)	
RAPGEF2	Guanine nucleotide exchange factor, Ras; Motility/polarity/chemotaxis	Q9Y4G8	9693	RAPGEF2	4q32.1	human	S960	PHOSPHORYLATION	1245534	KKRVRRSsFLNAKKL		activity, induced	cell adhesion, altered			4641424	1	12	120	Rap1 activation	
TFEB	DNA binding protein	Q9R210	21425	Tfeb		mouse	S468	PHOSPHORYLATION	4785147	SSRRSSFsMEEGDVL		protein stabilization	transcription, induced			27928005	1	3	0		
SLBP	RNA binding protein	Q14493	7884	SLBP	4p16.3	human	T61	PHOSPHORYLATION	466351	ERRPESFtTPEGPKP		protein degradation				8129; 2807217	2	1	9		
DUSP3	EC 3.1.3.16; EC 3.1.3.48; Motility/polarity/chemotaxis; Protein phosphatase, dual-specificity	P51452	1845	DUSP3	17q21	human	Y138	PHOSPHORYLATION	448718	SPTLVIAyLMMRQKM	DSPc	enzymatic activity, induced				1882	1	1	0	When ZAP-70 was reintroduced into the ZAP-70(-) JURKAT cells, DUSP3 regained its ability to inhibit MAPK responses.	
Casp2	Apoptosis; EC 3.4.22.-; EC 3.4.22.55; Protease	P42575	835	CASP2	7q34-q35	human	S157	PHOSPHORYLATION	456810	LYKKLRLsTDTVEHS		protein conformation; activity, inhibited				6869	1	0	0	lack of phosphorylation of this residue leads to Casp's dimerization and activation 	
PAR3-beta	Adaptor/scaffold; Motility/polarity/chemotaxis	Q8TEW8	117583	PARD3B	2q33.3	human	S746	PHOSPHORYLATION	455652	LGLKKSSsLESLQTA		molecular association, regulation		14-3-3 zeta(INDUCES)		5512	1	13	0		
CARD9	Adaptor/scaffold	Q9H257	64170	CARD9	9q34.3	human	T533	PHOSPHORYLATION	1206000	TGSDNTDtEGS____		activity, inhibited				1172811	1	1	0	impairs ability of CARD9 to activate NF-kB 	
CACNG2	Channel, calcium; Membrane protein, integral; Membrane protein, multi-pass	O88602	12300	Cacng2		mouse	S253	PHOSPHORYLATION	455307	PSHSRDAsPVGVKGF	Tetraspannin	activity, induced; intracellular localization				22913905; 4485	1	6	0	AMPAR immobilization in synaptic membrane; enhances AMPA receptor responses and is required for long-term potentiation	
KCNJ13	Channel, potassium; Membrane protein, integral; Membrane protein, multi-pass	O60928	3769	KCNJ13	2q37	human	S287	PHOSPHORYLATION	6039503	EICQRRTsYLPSEIM	IRK	activity, induced				5930008	1	0	0		
BubR1	EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor)	Q9Z1S0	12236	Bub1b		mouse	K243	ACETYLATION	7761217	SRVGGALkAPGQSRG		molecular association, regulation	carcinogenesis, inhibited; cytoskeletal reorganization			28722156	3	0	0	acetylation site necessary for embryonic development, spontaneous tumorigenesis in K243R/+ mutant mice, mutant shows: aneuploidy and premature sister chromatid separations, weakened spindle assembly checkpoint, defects in kinetochore-microtubule attachments acetylation of at BubR1 is required for recruiting PP2A-B56-alpha phosphatase to kinetochore	
merlin	Cytoskeletal protein; Motility/polarity/chemotaxis	P46662	18016	Nf2		mouse	S518	PHOSPHORYLATION	448282	DTDMKRLsMEIEKEK	ERM		cytoskeletal reorganization; cell growth, altered			15331006	21	17	1	neurite outgrowth	
PDX1	DNA binding protein; Transcription factor	P52946	18609	Pdx1		mouse	T152	PHOSPHORYLATION	470134	EENKRTRtAYTRAQL	Homeobox	intracellular localization				9035	1	0	0		
E2F4	DNA binding protein	E1BUH4		E2F4		chicken	T261	PHOSPHORYLATION	25571901	PSSTQPStPTPSSTQ			cell cycle regulation; apoptosis, induced			25561501	1	0	0		
SNCAIP	Vesicle protein	Q9Y6H5	9627	SNCAIP	5q23.2	human	S556	PHOSPHORYLATION	469990	AQKSEGKsLPSSPSS		protein stabilization; molecular association, regulation; protein processing		14-3-3 beta(INDUCES)		8838	1	0	3	14-3-3 enhances phosphorylation of SNCIAP by GSK3B. Inhibition of GSK3B  increases formation of SNCIAP cytoplasmic inclusion bodies.	
FAK	EC 2.7.1.112; EC 2.7.10.2; KINASE; Kinase, protein; Protein kinase, TK; Protein kinase, tyrosine (non-receptor)	Q00944	396416	PTK2		chicken	Y577	PHOSPHORYLATION	447890	YMEDSTYyKASKGKL	Pkinase_Tyr	activity, induced; phosphorylation; enzymatic activity, induced				2577; 1087	64	29	1766		
GTF2I iso2	DNA binding protein; Transcription, coactivator/corepressor	P78347-2	2969	GTF2I	7q11.23	human	Y462	PHOSPHORYLATION	448252	EAHPNDLyVEGLPEN	GTF2I		transcription, altered			1722	1	2	2		
TIE2	EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Protein kinase, TK; Protein kinase, tyrosine (receptor)	Q02858	21687	Tek		mouse	Y1100	PHOSPHORYLATION	450256	MLEERKTyVNTTLYE		molecular association, regulation	transcription, altered	GRB7(INDUCES); SHP-2(INDUCES); GRB14(INDUCES); PIK3R1(INDUCES); Grb2(INDUCES)		3501; 3996	5	0	0		
EGLN2	EC 1.14.11.-; EC 1.14.11.29; Oxidoreductase	Q96KS0	112398	EGLN2	19q13.2	human	S234	PHOSPHORYLATION	4213802	QRAIPPRsIRGDQIA		enzymatic activity, inhibited				4049505	1	0	0		
CLEC1B	Membrane protein, integral; Receptor, misc.	Q9P126	51266	CLEC1B	12p13.2	human	Y7	PHOSPHORYLATION	13244602	_MQDEDGyITLNIKT		molecular association, regulation; activity, inhibited		Syk(INDUCES)		12778811	1	0	0	Clec1b Y7F mutant has an inhibitory effect on signaling by wt Clec1b	
PREX1	Guanine nucleotide exchange factor, Rac/Rho	Q8TCU6	57580	PREX1	20q13.13	human	S605	PHOSPHORYLATION	18704702	DEEMEGTsSKNKQLR		activity, induced				18668001	1	0	0		
HABP4	Transcription regulation	Q5JVS0	22927	HABP4	9q22.3-q31	human	T375	PHOSPHORYLATION	11380903	GRGARGGtRGGRGRI		molecular association, regulation; intracellular localization		RACK1(DISRUPTS)		10296911	1	0	0	HABP4 associates with RACK1 in the nucleus but exits after activation with PMA	
ADRB3 iso2	GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR	P25962-2	11556	Adrb3		mouse	S389	PHOSPHORYLATION	456902	QSPPLNSsLLREPRH		activity, induced				6837	1	0	0	mutation of serines 388 and 389 to alanine abrogated cAMP accumulation in response to CL316243.	
GluR1	Channel, calcium; Channel, ligand-gated; Membrane protein, integral; Membrane protein, multi-pass	P19490	50592	Gria1		rat	S836	PHOSPHORYLATION	467226	CYKSRSEsKRMKGFC		activity, induced; intracellular localization				8154	7	0	0	promotes receptor incorporation into the synapse	
SOS1	Adaptor/scaffold; Guanine nucleotide exchange factor, Ras; Motility/polarity/chemotaxis	Q07889	6654	SOS1	2p21	human	S1132	PHOSPHORYLATION	451313	TLPHGPRsASVSSIS		molecular association, regulation		Grb2(DISRUPTS)		3524	1	0	0		
CENPT	DNA replication	F1NPG5		CENPT		chicken	T72	PHOSPHORYLATION	3903606	FSELDNAtPRVMLRK		molecular association, regulation		SPC25(INDUCES); SPBC24(INDUCES)		27519647	0	2	7		
IL7R	Membrane protein, integral; Receptor, cytokine	P16872	16197	Il7r		mouse	Y449	PHOSPHORYLATION	451291	VLNQEEAyVTMSSFY		activity, induced; activity, inhibited	translation, altered; apoptosis, inhibited; transcription, altered			7249; 12014	3	0	0	Proteomics analysis of WT and Y449F IL7R shows that various proteins are effected (both upregulated and downregulated differences).  Not specified whether they are transcriptional or translational effects.  For example, GIMAP4, Annexin A6, STAT1, CDC42 were downregulated. BIT1 and FKBP51 were upregulated in the mutant.	
Casp9	Apoptosis; EC 3.4.22.62; Protease	P55211	842	CASP9	1p36.21	human	S183	PHOSPHORYLATION	448528	GLRTRTGsNIDCEKL	Peptidase_C14	molecular association, regulation; enzymatic activity, inhibited		APAF(DISRUPTS)		4597	1	0	0	inhibits the assembly of the apoptosome in response to cytochrome c	
TNNI3	Actin binding protein; Motility/polarity/chemotaxis; Motor protein	P19429	7137	TNNI3	19q13.4	human	T51	PHOSPHORYLATION	6796402	SRKLQLKtLLLQIAK	Troponin	molecular association, regulation; protein conformation		C16orf82(INDUCES); TNC(INDUCES)		6702300	1	1	0		
Cdc25B iso2	EC 3.1.3.48; Motility/polarity/chemotaxis; Nuclear receptor co-regulator; PHOSPHATASE; Protein phosphatase, dual-specificity	P30305-2	994	CDC25B	20p13	human	S309	PHOSPHORYLATION	448409	QRLFRSPsMPCSVIR	M-inducer_phosp	phosphorylation		P38A(INDUCES)		1268100	11	3	23	phospho-p38  are Cdc25B S309-p are colocalized during prophase.
 	
PPP1R12B	Activator protein; Motility/polarity/chemotaxis; Protein phosphatase, regulatory subunit	O60237	4660	PPP1R12B	1q32.1	human	T646	PHOSPHORYLATION	478177	ARQTRRStQGVTLTD		activity, inhibited				2865433	2	4	73	inhibits phosphatase activity of PP1c-delta	
IFNAR1	Membrane protein, integral; Receptor, cytokine	P17181	3454	IFNAR1	21q22.11	human	S532	PHOSPHORYLATION	11927800	KKYSSQTsQDSGNYS		protein degradation; ubiquitination; phosphorylation				11387210	4	0	0	stimulates phosphorylation of S535	
SLC6A4	Membrane protein, integral; Membrane protein, multi-pass; Transporter	P31645	6532	SLC6A4	17q11.2	human	T81	PHOSPHORYLATION	12610000	LHQGEREtWGKKVDF	SNF	protein conformation				12525220	1	0	0		
TERT	DNA binding protein; EC 2.7.7.49; Transferase	O14746	7015	TERT	5p15.33	human	S227	PHOSPHORYLATION	11418800	GARRRGGsASRSLPL		enzymatic activity, induced				10274618	2	0	0		
FAM125A	Adaptor/scaffold	Q96EY5	93343	FAM125A	19p13.11	human	T130	PHOSPHORYLATION	13211302	RLSGKTKtVPGYLRI	DUF2464	protein processing				12660601	1	1	0	inhibition of HIV-1 release and infectivity	
ERK3	EC 2.7.11.24; KINASE; Kinase, protein; Protein kinase, CMGC; Protein kinase, Ser/Thr (non-receptor)	Q16659	5597	MAPK6	15q21	human	S705	PHOSPHORYLATION	13830501	TPSAMKSsPQIPHQT		protein stabilization				13326314	1	1	0		
PBK	Cancer Testis Antigen (CTA); EC 2.7.12.2; KINASE; Kinase, protein; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor)	Q96KB5	55872	PBK	8p21.2	human	T9	PHOSPHORYLATION	451735	EGISNFKtPSKLSEK		molecular association, regulation; enzymatic activity, induced	cytoskeletal reorganization	CCNB1(INDUCES); TUBA4A(INDUCES); CDK1(INDUCES)		4689; 7708	4	2	2		
Chk2	EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, CAMK; Protein kinase, Ser/Thr (non-receptor)	O96017	11200	CHEK2	22q12.1	human	T387	PHOSPHORYLATION	447552	LMRTLCGtPTYLAPE	Pkinase	intracellular localization; protein conformation; enzymatic activity, induced	cell cycle regulation			2452301; 7255; 15658725; 2236; 1025	15	2	0		
Chk2	EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, CAMK; Protein kinase, Ser/Thr (non-receptor)	O96017	11200	CHEK2	22q12.1	human	S379	PHOSPHORYLATION	981401	SKILGETsLMRTLCG	Pkinase	ubiquitination; intracellular localization; enzymatic activity, induced	apoptosis, induced			15658725; 2903904	4	6	1		
CFTR	Channel, chloride; EC 3.6.3.49; Hydrolase; Membrane protein, integral; Membrane protein, multi-pass; Transporter	P13569	1080	CFTR	7q31.2	human	S700	PHOSPHORYLATION	449978	FGEKRKNsILNPINS	CFTR_R	molecular association, regulation; enzymatic activity, inhibited		CFTR(INDUCES)		4474	6	4	0		
CXCR4	GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR	P61073	7852	CXCR4	2q21	human	S339	PHOSPHORYLATION	458320	GKRGGHSsVSTESES		intracellular localization				9985925	4	2	6		
TrkC	EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Protein kinase, TK; Protein kinase, tyrosine (receptor)	Q03351	29613	Ntrk3		rat	Y516	PHOSPHORYLATION	450003	PVIENPQyFRQGHNC		molecular association, regulation		Shc1(INDUCES); PLCG1(INDUCES)		3827	2	4	66		
SLC25A4	Membrane protein, integral; Membrane protein, multi-pass; Mitochondrial; Transporter	P12235	291	SLC25A4	4q35	human	Y191	PHOSPHORYLATION	462625	IIIYRAAyFGVYDTA	Mito_carr; TM		cell growth, altered			12021334	1	10	341	required for an efficient oxidative growth in yeast 	
PIN4	EC 5.2.1.8; Isomerase; Mitochondrial	Q9Y237	5303	PIN4	Xq13	human	S19	PHOSPHORYLATION	3188102	AGKGGAAsGSDSADK		molecular association, regulation; intracellular localization			DNA(DISRUPTS)	8719	1	0	0		
APC	Motility/polarity/chemotaxis; Tumor suppressor	P25054	324	APC	5q21-q22	human	S2793	PHOSPHORYLATION	10211300	YNPSPRKsSADSTSA	EB1_binding	molecular association, regulation		EB1(DISRUPTS)		9985931	0	0	0		
Snail2	Apoptosis; C2H2-type zinc finger protein; Motility/polarity/chemotaxis; Transcription factor	O43623	6591	SNAI2	8q11	human	S92	PHOSPHORYLATION	25603910	RVSPPPPsDTSSKDH		protein degradation; intracellular localization	transcription, induced			25582516	1	0	0	 WT localizes in cytosol and nucleus; transcriptional activity of E-cadherin;  mutants enhance epithelial-mesenchymal transition (EMT)	
SLAP-130	Adaptor/scaffold	O15117	2533	FYB	5p13.1	human	Y755	PHOSPHORYLATION	464285	CRNEEGKyGYVLRSY			cell motility, altered; cell adhesion, altered			15020906	1	2	204	promotes adhesion to ICAM-1; promotes cell migration	
Src	EC 2.7.10.2; KINASE; Kinase, protein; Protein kinase, TK; Protein kinase, tyrosine (non-receptor)	P00523	396442	SRC		chicken	Y416	PHOSPHORYLATION	448234	RLIEDNEyTARQGAK	Pkinase_Tyr	phosphorylation; enzymatic activity, induced	cell motility, altered; cell adhesion, altered; cell growth, altered			5870; 2558; 2307; 5721; 1277; 791; 5309422	267	61	3059		
ARRB2	Adaptor/scaffold	Q91YI4	216869	Arrb2		mouse	S361	PHOSPHORYLATION	3176604	ITLPRPQsAPRETDV		molecular association, regulation; receptor internalization, altered		CLTC(DISRUPTS)		8346	1	0	0	decreases beta2-adrenergic receptor internalization	
PERK	EC 2.7.11.1; KINASE; Kinase, protein; Membrane protein, integral; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor); Translation	Q9Z2B5	13666	Eif2ak3		mouse	T799	PHOSPHORYLATION	11073906	YTRSREGtSSSIVFE		enzymatic activity, inhibited	apoptosis, induced			22689019	1	0	1	Phosphorylation inactivates PERK, promoting proapoptotic effects of Akt.	
APC	Motility/polarity/chemotaxis; Tumor suppressor	P25054	324	APC	5q21-q22	human	S1392	PHOSPHORYLATION	450135	SRCTSVSsLDSFESR	APC_crr		transcription, altered			2751	1	1	0		
ROMK	Channel, potassium; Membrane protein, integral; Membrane protein, multi-pass	P35560	24521	Kcnj1		rat	S313	PHOSPHORYLATION	2461200	ATCQVRTsYVPEEVL	IRK	activity, induced; protein conformation				2451817	5	0	0		
Gab2	Adaptor/scaffold	Q9UQC2	9846	GAB2	11q14.1	human	Y266	PHOSPHORYLATION	448878	TEFRDSTyDLPRSLA		molecular association, regulation		CrkL(INDUCES)		6227	1	9	224		
MYH14	Motility/polarity/chemotaxis; Motor protein	Q6URW6	71960	Myh14		mouse	T1957	PHOSPHORYLATION	27623908	RRGPLTFtTRTVRQV			cytoskeletal reorganization			27619342	0	0	0	Phosphorylation of either residue abolishes filament assembly of MYH14 Rod1296-1854.	
Rb	Nuclear receptor co-regulator; Transcription, coactivator/corepressor; Tumor suppressor	P06400	5925	RB1	13q14.2	human	S807	PHOSPHORYLATION	447980	PGGNIYIsPLKSPYK	Rb_C	molecular association, regulation	cell cycle regulation; transcription, altered; cell growth, altered	E2F1(DISRUPTS); Abl iso2(DISRUPTS)		776; 6906; 4759; 5309405; 777; 6276	48	22	110		
GRK2	EC 2.7.11.15; KINASE; Kinase, protein; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor)	P21146	282682	ADRBK1		cow	Y86	PHOSPHORYLATION	447727	AKPLVEFyEEIKKYE	RGS	enzymatic activity, induced				2831776	5	0	0		
desmin	Cytoskeletal protein; Motility/polarity/chemotaxis	P17661	1674	DES	2q35	human	S12	PHOSPHORYLATION	449612	YSSSQRVsSYRRTFG	Filament_head	intracellular localization	cytoskeletal reorganization			2253	1	0	0	Mutated desmin sites showed failure of desmin filaments to segregate into daughter cells. ; Phosphorylated at the clevage furrow during cytokinesis. 	
Chk1	EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, CAMK; Protein kinase, Ser/Thr (non-receptor)	Q8AYC9	374260	STT3A		chicken	S301	PHOSPHORYLATION	465528	IRSDTDFsPVKSALG	Paramyxo_PNT	enzymatic activity, induced	cell cycle regulation			20722939	5	9	1		
cPLA2	EC 3.1.1.4; EC 3.1.1.5; Lipid Metabolism - alpha-linolenic acid; Lipid Metabolism - arachidonic acid; Lipid Metabolism - ether lipid; Lipid Metabolism - glycerophospholipid; Lipid Metabolism - linoleic acid; Phospholipase	P47713	18783	Pla2g4a		mouse	S505	PHOSPHORYLATION	447597	LNTSYPLsPLRDFSS	PLA2_B	enzymatic activity, induced				650; 1041	22	6	8		
E2A	DNA binding protein; Transcription factor	P15923	6929	TCF3	19p13.3	human	S352	PHOSPHORYLATION	465681	SSNNFSSsPSTPVGS		activity, inhibited	transcription, inhibited			10353939	2	0	3		
SgK269	EC 2.7.10.2; KINASE; Kinase, protein; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor)	Q9H792	79834	PEAK1	15q24.3	human	Y665	PHOSPHORYLATION	450418	TSVISHTyEEIETES		intracellular localization	cell motility, induced; cell adhesion, induced			27132462	1	3	23	Src activity is required for SgK269 localization to focal adhesions and SgK269 adhesion effects.	
INCENP	Cell cycle regulation; EC 2.7.11.1	Q9NQS7	3619	INCENP	11q12.3	human	S893	PHOSPHORYLATION	450467	PRYHKRTsSAVWNSP		activity, induced				3012	3	13	15		
PDCD4	Apoptosis	Q53EL6	27250	PDCD4	10q24	human	S71	PHOSPHORYLATION	1211014	RKNSSRDsGRGDSVS		protein degradation; molecular association, regulation	cell cycle regulation; translation, altered; cell growth, altered	BTRC(INDUCES)		2587201	1	5	17		
TOB1	Adaptor/scaffold; Cell cycle regulation	P50616	10140	TOB1	17q21	human	S164	PHOSPHORYLATION	455537	FGHSAAVsPTFMPRS		activity, inhibited	cell cycle regulation; cell growth, altered			5435; 5416	3	0	0	the antiproliferative activity of TOB1 is inhibited by phosphorylation.; the antiproliferative function of TOB1 is inhibited by phosphorylation.	
MyoD	DNA binding protein; RNA splicing; Transcription factor	P10085	17927	Myod1		mouse	Y30	PHOSPHORYLATION	449872	FETADDFyDDPCFDS	Basic	activity, inhibited				2416	2	0	0		
PDE4A iso2	EC 3.1.4.17; Nucleotide Metabolism - purine; Phosphodiesterase	P27815-2	5141	PDE4A	19p13.2	human	S119	PHOSPHORYLATION	458389	ATSQRREsFLYRSDS		enzymatic activity, induced				8721	4	7	0		
Rb-like 2	Transcription, coactivator/corepressor	Q08999	5934	RBL2	16q12.2	human	S1112	PHOSPHORYLATION	449743	LLEDGSEsPAKRICP		molecular association, regulation	cell cycle regulation	E2F4(DISRUPTS)		1200; 5981	3	4	1		
NDR1	EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor)	Q15208	11329	STK38	6p21	human	S281	PHOSPHORYLATION	448828	NRRQLAFsTVGTPDY	Pkinase	intracellular localization; phosphorylation; enzymatic activity, induced	cytoskeletal reorganization	MOBP(INDUCES)		25082851; 7121; 1998	5	1	11	reduction in dendritic branching and length ; Myristoylated palmitylated NDR1 is membrane targeted and constitutively active (mp-HA-NDR1). When hMOB1A was coexpressed T444, and S281 phosphorylation were greatly increased in wild-type. Association with hMOB1A induces autophosphorylation of NDR1 on S281. A chimera of PKB and and the C1 domain of PKCa fused to hMOB1A recruited this chimera protein to the membrane after TPA treatment. TPA induction  further induced the phosphorylation of NDR1 S281 and T444. A NDR1 mutant  deficient in hMOB1A  binding did not show an increase in phosphorylation.	
CITED1	Nuclear receptor co-regulator	P97769	12705	Cited1		mouse	S63	PHOSPHORYLATION	27937114	KANGVPTsSSGSTSP	CITED	intracellular localization	cell differentiation, induced			27780046	1	0	0	S63/64/65/67/69/73/79/80/84A mutation in CITED1 inhibits its translocation into the nucleus and osteoblasts differentiation	
Rin1	Guanine nucleotide exchange factor, Rab	Q13671	9610	RIN1	11q13.2	human	S292	PHOSPHORYLATION	4949757	QLLRRESsVGYRVPA			cell motility, altered			19016929	1	3	5		
VAV3	Actin binding protein; Adaptor/scaffold; Guanine nucleotide exchange factor, Rac/Rho; Motility/polarity/chemotaxis; Nuclear receptor co-regulator	Q9R0C8	57257	Vav3		mouse	Y141	PHOSPHORYLATION	4834228	SINDEDIyKGLPDLI			cell cycle regulation; cell motility, altered			2790302	0	2	4		
TGM2	EC 2.3.2.13; KINASE; Transferase	P21980	7052	TGM2	20q12	human	S215	PHOSPHORYLATION	467222	GRDCSRRsSPVYVGR		molecular association, regulation		14-3-3 epsilon(INDUCES)		8148	1	0	0		
BAF	DNA binding protein	O75531	8815	BANF1	11q13.1	human	T2	PHOSPHORYLATION	7105310	______MtTSQKHRD	BAF	molecular association, regulation; intracellular localization			DNA(DISRUPTS)	12619500	1	0	0		
TTK	Cancer Testis Antigen (CTA); EC 2.7.12.1; KINASE; Kinase, protein; Protein kinase, Other; Protein kinase, dual-specificity	P33981	7272	TTK	6q13-q21	human	S582	PHOSPHORYLATION	4145513	LNKLQQHsDKIIRLY	Tubulin; Pkinase	enzymatic activity, induced				4042509	1	0	0	in vitro	
TDP1	DNA repair; EC 3.1.4.-; Phosphodiesterase	Q9NUW8	55775	TDP1	14q32.11	human	S81	PHOSPHORYLATION	11279401	PKRQKSGsQEDLGWC		protein stabilization; molecular association, regulation; intracellular localization		XRCC1(INDUCES)		11189918	3	1	0	; accumulates at DNA damage sites;  TDP1 S81A mutant is defective in DNA repair and survival	
RAF1	EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, Ser/Thr (non-receptor); Protein kinase, TKL	P04049	5894	RAF1	3p25	human	S296	PHOSPHORYLATION	455218	SPSALSSsPNNLSPT		molecular association, regulation; intracellular localization; enzymatic activity, inhibited; enzymatic activity, induced		HRas(DISRUPTS)		4444; 4487; 1962902	4	15	44	phosphorylation of S289, S296, and S301 sustains and increases kinase activity	
KCNK18	Channel, ligand-gated; Channel, potassium; Membrane protein, integral; Membrane protein, multi-pass	Q6VV64	332396	Kcnk18		mouse	S276	PHOSPHORYLATION	12525800	VLGRLSCsILSNLDE		activity, induced; activity, inhibited				13354719; 12482287	3	0	0		
CDH5	Cell adhesion; Membrane protein, integral; Motility/polarity/chemotaxis	P55284	12562	Cdh5		mouse	Y685	PHOSPHORYLATION	455658	MDARPAVyTQVQKPP	Cadherin_C	molecular association, regulation; phosphorylation	cell growth, altered	CSK(INDUCES)		5570	4	2	155		
Mos	EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor)	P12965	397924	mos		frog	S105	PHOSPHORYLATION	466947	NSLASRQsFWAELNA	Pkinase	enzymatic activity, inhibited				8141	1	1	0	dephosphorylation of S105 is necessary for the mitotic activation of Mos	
MOR-1	GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR	P42866	18390	Oprm1		mouse	T379	PHOSPHORYLATION	20727900	EHPSTANtVDRTNHQ		receptor internalization, induced	endocytosis, induced			20726800	3	1	0	endocytosis of MOR-1	
NFAT4	DNA binding protein; Transcription factor	Q12968	4775	NFATC3	16q22.2	human	T210	PHOSPHORYLATION	11507603	FTLGSPLtSPGGSPG		intracellular localization				10274612	1	0	0	cytoplasmic localization (inhibition of nuclear localization)	
ANKRD28	Protein phosphatase, regulatory subunit	O15084	23243	ANKRD28	3p25.1	human	S1007	PHOSPHORYLATION	459224	INRYTNTsKTVSFEA		intracellular localization	transcription, inhibited	PPP1CA(DISRUPTS)		9590; 7642	2	1	0		
PRC1	Cell cycle regulation; Cytoskeletal protein; Microtubule binding protein; Motility/polarity/chemotaxis	O43663	9055	PRC1	15q26.1	human	T578	PHOSPHORYLATION	26331400	SINSVAStYSEFAKD	MAP65_ASE1	phosphorylation				25785411	1	0	0	Docking site phosphorylation at T616 is regulated  T578  phosphorylation.	
TRHR	GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR	Q01717	25570	Trhr		rat	T365	PHOSPHORYLATION	465592	KESDRFStELDDITV		intracellular localization; receptor internalization, altered				1172827; 14551416; 8037; 9381	5	0	0		
14-3-3 beta	Adaptor/scaffold	P31946	7529	YWHAB	20q13.1	human	S186	PHOSPHORYLATION	449845	FYYEILNsPEKACSL	14-3-3	molecular association, regulation		Abl iso2(DISRUPTS)		5307	3	5	0		
MDM2	EC 6.3.2.-; EC 6.3.2.19; Inhibitor protein; Ligase; UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase	Q00987	4193	MDM2	12q14.3-q15	human	S121	PHOSPHORYLATION	15714602	ESSDSGTsVSENRCH		protein degradation; molecular association, regulation; ubiquitination		FBW1B(INDUCES)		15675518	1	1	0		
PKCD	EC 2.7.10.2; EC 2.7.11.13; KINASE; Kinase, protein; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor)	Q05655	5580	PRKCD	3p21.31	human	Y187	PHOSPHORYLATION	447579	WGLNKQGyKCRQCNA	DUF4206; C1_1; Prok-RING_1; PHD	activity, inhibited; phosphorylation	apoptosis, altered; apoptosis, induced			3522; 4264901	6	0	0	ERK phosphorylation/activation	
C/EBP-beta	DNA binding protein; Motility/polarity/chemotaxis; Transcription factor	P21272	24253	Cebpb		rat	R114	MONO-METHYLATION	13373505	YGYVSLGrAGAKAAP		molecular association, regulation	cell growth, induced; transcription, induced		DNA(INDUCES)	13354731	0	1	0		
GUK1	EC 2.7.4.8; KINASE; Kinase, other; Nucleotide Metabolism - purine	Q64520	14923	Guk1		mouse	S37	PHOSPHORYLATION	7493500	SIFGFSVsHTTRNPR	Guanylate_kin	enzymatic activity, induced	cell growth, altered			7483308	1	0	0	Mutants display a drug resistance phenotype to 6-GT and decreased enzymatic activity. 	
Mer	EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Protein kinase, TK; Protein kinase, tyrosine (receptor)	Q12866	10461	MERTK	2q14.1	human	Y753	PHOSPHORYLATION	449989	KKIYSGDyYRQGRIA	Pkinase_Tyr	enzymatic activity, induced				2539	1	11	403		
SPHK1	EC 2.7.1.-; EC 2.7.1.91; KINASE; Kinase, lipid; Lipid Metabolism - sphingolipid	Q8CI15	20698	Sphk1		mouse	S225	PHOSPHORYLATION	460682	VASKRPAsTLVQKGP		intracellular localization				10430803	10	6	0		
ABCC9	Channel, potassium; Membrane protein, integral; Membrane protein, multi-pass; Transporter	P70170	20928	Abcc9		mouse	S1465	PHOSPHORYLATION	483975	RAFVRKSsILIMDEA	ABC_tran	activity, induced				8597	2	0	0		
FOXO3A	Autophagy; DNA binding protein; Transcription factor	O43524	2309	FOXO3	6q21	human	S253	PHOSPHORYLATION	449108	APRRRAVsMDNSNKY	Fork_head	molecular association, regulation; intracellular localization; activity, inhibited; phosphorylation	cell cycle regulation; apoptosis, altered; apoptosis, inhibited; transcription, altered; transcription, inhibited	14-3-3 beta(INDUCES); 14-3-3 zeta(INDUCES)		6115915; 22433508; 2148; 679; 2996900; 9093; 13320405	19	6	61		
PSRC1	Tumor suppressor	Q6PGN9	84722	PSRC1	1p13.3	human	S70	PHOSPHORYLATION	472052	RLSLGPLsPEKLEEI			cytoskeletal reorganization			18898704	1	10	9		
MYH9	Actin binding protein; Motility/polarity/chemotaxis; Motor protein	P35579	4627	MYH9	22q13.1	human	T1800	PHOSPHORYLATION	2482302	KLQEMEGtVKSKYKA	Myosin_tail_1; AAA_13	intracellular localization	cytoskeletal reorganization			2451809	1	1	1		
PAR-4	Apoptosis	Q62627	64513	Pawr		rat	S249	PHOSPHORYLATION	456965	SRHNRDTsAPANFAS	ATG16; DUF724; IncA; DUF4164	intracellular localization	apoptosis, inhibited			6953	1	0	0	phosphorylation by Akt prevents apoptosis	
DAPK3	EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, CAMK; Protein kinase, Ser/Thr (non-receptor)	O43293	1613	DAPK3	19p13.3	human	T299	PHOSPHORYLATION	454893	PERRRLKtTRLKEYT	SPX	intracellular localization				4344; 15571613	3	0	0		
SRPK2	EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, CMGC; Protein kinase, Ser/Thr (non-receptor)	P78362	6733	SRPK2	7q22-q31.1	human	T492	PHOSPHORYLATION	483237	PSHDRSRtVSASSTG		molecular association, regulation; intracellular localization; enzymatic activity, induced	cell cycle regulation; transcription, altered	14-3-3 beta(INDUCES); 14-3-3 epsilon(INDUCES)		9980417	1	3	0	nuclear translocation of SRPK2 is blocked by 14-3-3	
PLCB3	Carbohydrate Metabolism - inositol phosphate; EC 3.1.4.11; Phospholipase	Q01970	5331	PLCB3	11q13	human	S1105	PHOSPHORYLATION	448448	LDRKRHNsISEAKMR	PLC-beta_C	enzymatic activity, inhibited				758	4	10	213		
CDH1	Cell adhesion; Membrane protein, integral; Motility/polarity/chemotaxis; UBIQUITIN LIGASE; Ubiquitin ligase	P09803	12550	Cdh1		mouse	S848	PHOSPHORYLATION	15754601	GSEAASLsSLNSSES	Cadherin_C	molecular association, regulation		CTNNB1(INDUCES)		15754200	1	1	0		
Ig-alpha	Immunoglobulin superfamily; Membrane protein, integral	P11911	12518	Cd79a		mouse	Y193	PHOSPHORYLATION	473329	NLDDCSMyEDISRGL	ITAM	activity, induced; molecular association, regulation; phosphorylation	cell differentiation, altered	Syk(INDUCES)		9303; 1692; 3517	3	1	26	Ca(2+) signaling	
TEBP	Chaperone; EC 5.3.99.3; Isomerase; Transferase	Q15185	10728	PTGES3	12q13.3|12	human	S113	PHOSPHORYLATION	451129	WKDWEDDsDEDMSNF	Pkinase_C	molecular association, regulation; enzymatic activity, induced		HSP90A(INDUCES); CK2A1(INDUCES)		3331	3	70	368		
LKB1	Autophagy; EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, CAMK; Protein kinase, Ser/Thr (non-receptor)	Q15831	6794	STK11	19p13.3	human	S307	PHOSPHORYLATION	7710000	IRQIRQHsWFRKKHP	Pkinase	molecular association, regulation; intracellular localization	apoptosis, altered; cell growth, altered	STRAD(INDUCES); AMPKA1(INDUCES); exportin 1(INDUCES)		7709700	2	0	0	in the presence of ONOO(-);  supresses angiogenesis	
CaR	GPCR, family 3; Membrane protein, integral; Membrane protein, multi-pass; Motility/polarity/chemotaxis; Receptor, GPCR	P41180	846	CASR	3q13	human	S915	PHOSPHORYLATION	11488700	STPSSSIsSKSNSED		activity, induced				11484401	1	0	0		
VANGL2	Adaptor/scaffold; Membrane protein, integral; Membrane protein, multi-pass	Q91ZD4	93840	Vangl2		mouse	S5	PHOSPHORYLATION	18460402	___MDTEsQYSGYSY		activity, induced; protein stabilization				18410837	1	0	0		
SKAP55	Adaptor/scaffold; Motility/polarity/chemotaxis	Q86WV1	8631	SKAP1	17q21.32	human	Y219	PHOSPHORYLATION	451307	LSSLTIPyEEDEEEE		molecular association, regulation		CD45(INDUCES)		3533	1	0	0		
MARK2	EC 2.7.11.1; EC 2.7.11.26; KINASE; Kinase, protein; Protein kinase, CAMK; Protein kinase, Ser/Thr (non-receptor)	Q7KZI7	2011	MARK2	11q13.1	human	S212	PHOSPHORYLATION	450068	KLDTFCGsPPYAAPE	Pkinase	enzymatic activity, inhibited	cell differentiation, altered; cytoskeletal reorganization			2704327	5	6	10	GSK3B coexpression inhibits MARK2 enzymatic activity.	
NPM-ALK	Kinase, protein; Protein kinase, TK; Protein kinase, tyrosine (receptor)	AAA58698		NPM/ALK		human	S164	PHOSPHORYLATION	27275103	CFAGKTSsISDLKEV		phosphorylation	carcinogenesis, altered; cell growth, altered			17482910	1	1	0		
NFkB-p105	DNA binding protein; Transcription factor	P19838	4790	NFKB1	4q24	human	S932	PHOSPHORYLATION	447771	CDSGVETsFRKLSFT		protein degradation				1189; 2611	4	0	0		
KLF5	C2H2-type zinc finger protein; DNA binding protein; Transcription factor	Q13887	688	KLF5	13q22.1	human	S303	PHOSPHORYLATION	14652801	QATYFPPsPPSSEPG		protein degradation; molecular association, regulation; ubiquitination	carcinogenesis, altered	FBXW7(INDUCES)		14551404	1	0	0	FBXW7-mediated KLF5 ubiquitination and degradation	
ADAM22	Cell adhesion; Membrane protein, integral; Motility/polarity/chemotaxis	Q9P0K1	53616	ADAM22	7q21	human	S834	PHOSPHORYLATION	469108	NGRPRSNsWQGNLGG		protein stabilization; molecular association, regulation; intracellular localization		14-3-3 beta(INDUCES); 14-3-3 theta(INDUCES); 14-3-3 zeta(INDUCES); 14-3-3 epsilon(INDUCES); 14-3-3 gamma(INDUCES); 14-3-3 eta(INDUCES)		8234	1	13	96		
MKK4	EC 2.7.12.2; KINASE; Kinase, protein; Protein kinase, STE; Protein kinase, dual-specificity	P45985	6416	MAP2K4	17p12	human	T261	PHOSPHORYLATION	447656	LVDSIAKtRDAGCRP	Pkinase	enzymatic activity, induced	transcription, induced			5410107; 4654; 2852638	23	3	0	Il-6 induced 	
p47phox	EC 1.-.-.-; Oxidoreductase	P14598	653361	NCF1	7q11.23	human	S359	PHOSPHORYLATION	451729	EERQTQRsKPQPAVP	p47_phox_C	activity, induced; molecular association, regulation; intracellular localization; phosphorylation; enzymatic activity, induced		CYBA(INDUCES)		3990; 8704	7	0	0	promotes the phosphorylation of other p47phox PKC sites	
UBF	DNA binding protein; Transcription factor	P25976	21429	Ubtf		mouse	S389	PHOSPHORYLATION	450170	INKKQTTsPASKKPS			transcription, altered			2791	3	2	1		
GLI3	C2H2-type zinc finger protein; Transcription factor	P10071	2737	GLI3	7p13	human	S877	PHOSPHORYLATION	15501382	CFSSRRSsEASQAEG		protein processing	transcription, inhibited			25779400	1	0	0		
KIF23	Microtubule binding protein; Motility/polarity/chemotaxis; Motor protein	Q02241	9493	KIF23	15q23	human	S911	PHOSPHORYLATION	459840	NGSRKRRsSTVAPAQ		intracellular localization				7650	4	8	261	
relocation of KIF23 and AurB to the central spindle requires MKlp2; phosphorylated during anaphase and cytokinesis	
APP iso2	Apoptosis; Cell surface; Membrane protein, integral; Receptor, misc.; Transcription factor	P12023-2	11820	App		mouse	T668	PHOSPHORYLATION	448523	VEVDAAVtPEERHLS	APP_amyloid	molecular association, regulation; intracellular localization		Fe65(DISRUPTS); 14-3-3 gamma(DISRUPTS)		7391; 8101	30	2	3	Phosphorylation  of APP liberates FE65 from the membrane and then both are independently translocated into the nucleus. 	
Sam68	RNA binding protein	Q60749	20218	Khdrbs1		mouse	S58	PHOSPHORYLATION	449876	PRGGARAsPATQPPP		activity, induced	translation, altered			2423	1	8	0	regulates splicing	
SLC23A2	Membrane protein, integral; Membrane protein, multi-pass; Transporter	Q9EPR4	54338	Slc23a2		mouse	S403	PHOSPHORYLATION	483979	YYACARLsCAPPPPI	Xan_ur_permease	intracellular localization	cell differentiation, altered			11985	1	0	0	Phosphorylation is required for SLC3A2 localization in plasma membrane, and ascorbic acid uptake.	
DYN1	EC 3.6.5.5; Hydrolase; Microtubule binding protein; Motility/polarity/chemotaxis; Motor protein; Vesicle protein	P21575	140694	Dnm1		rat	S778	PHOSPHORYLATION	450206	GRRSPTSsPTPQRRA		molecular association, regulation	endocytosis, altered	endophilin 1(INDUCES); PACSIN1(INDUCES); PACSIN1(DISRUPTS)		11471; 7850	9	15	5	regulates synaptic vesicle endocytosis; interaction essential for  synaptic vesicle endocytosis	
MYBPC3	Myosin binding protein	O70468	17868	Mybpc3		mouse	S273	PHOSPHORYLATION	471079	RSAFRRTsLAGAGRR		molecular association, regulation	apoptosis, altered; cytoskeletal reorganization	MYBPC1(DISRUPTS)		9008	13	4	14	The triple aspartic acid mutation shows greater distance between the two thick myosin filaments (affects the steric arrangement of the filament distances) in heart tissue.  Mutation is cardioprotective during stress (ischemia-reprofusion injury) against apoptosis similar to isoproterenol treatment.	
Kv4.2	Channel, potassium; Membrane protein, integral; Membrane protein, multi-pass	Q63881		Kcnd2		rat	S438	PHOSPHORYLATION	2906103	ARIRAAKsGSANAYM		protein stabilization				8602	1	0	1		
PIGR	Immunoglobulin superfamily; Membrane protein, integral; Receptor, misc.	P01832	100328593	PIGR		rabbit	S744	PHOSPHORYLATION	451444	PKKAKRSsKEEADLA		intracellular localization				3635	1	4	0	Mutation of S744 drastically reduces transcytosys of dIgA.	
Shc3 iso2	Adaptor/scaffold; Motility/polarity/chemotaxis	Q92529-2	53358	SHC3	9q22.1	human	Y219	PHOSPHORYLATION	451258	DGSDHPYyNSIPSKM		molecular association, regulation		Crk(INDUCES); RapGEF1(INDUCES)		3475	3	2	8		
Akt1	EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor)	P47196	24185	Akt1		rat	T34	PHOSPHORYLATION	455493	FLLKNDGtFIGYKER	PH	enzymatic activity, inhibited				5311	1	0	0		
P2Y2	GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR; Receptor, misc.	P41231	5029	P2RY2	11q13.5-q14.1	human	S356	PHOSPHORYLATION	2909202	IEDVLGSsEDSRRTE		receptor desensitization, altered; intracellular localization				8702	1	0	0		
TRAF2	Autophagy; EC 6.3.2.-; Ligase; UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase	Q12933	7186	TRAF2	9q34	human	S55	PHOSPHORYLATION	7378202	QCGHRYCsFCLASIL	zf-C3HC4		apoptosis, inhibited			7313815	1	0	0	protects cells from stress-induced apoptosis	
Rad9	Apoptosis; Cell cycle regulation; DNA replication; Deoxyribonuclease; EC 3.1.11.2	Q99638	5883	RAD9A	11q13.1-q13.2	human	S272	PHOSPHORYLATION	447824	LSDTDSHsQDLGSPE		activity, induced	cell cycle regulation			1750	5	3	4		
neurofascin	Membrane protein, integral; Motility/polarity/chemotaxis	P97685	116690	Nfasc		rat	Y1212	PHOSPHORYLATION	452190	DGSFIGQyTVRKDKE	Bravo_FIGEY	molecular association, regulation		ANK1(DISRUPTS)		4103	1	0	0		
GR	DNA binding protein; Mitochondrial; Nuclear receptor; Transcription factor	P06536	24413	Nr3c1		rat	S232	PHOSPHORYLATION	447968	PSKDTNEsPWRSDLL	GCR	activity, induced	transcription, altered			1968367	27	1	0	induces hormone-dependent recruitment of GR to promoters (of tat, sult and gliz genes)	
TH iso3	Amino Acid Metabolism - tyrosine; EC 1.14.16.2; Endoplasmic reticulum; Mitochondrial; Oxidoreductase; Vesicle protein	P07101-3	7054	TH	11p15.5	human	S40	PHOSPHORYLATION	448545	RFIGRRQsLIEDARK	TOH_N	enzymatic activity, induced				7324135; 7484; 10167105	46	6	11		
NDEL1	Microtubule binding protein; Protease	Q9ERR1	83431	Ndel1		mouse	T245	PHOSPHORYLATION	3211851	GFGTSPLtPSARISA	NUDE_C	activity, induced; intracellular localization	cell motility, altered			2425202	2	3	3	Cdc42 activation	
ETV1	DNA binding protein; Transcription factor	P50549	2115	ETV1	7p21.3	human	T139	PHOSPHORYLATION	3059605	MRPSNPPtPSSTPVS	ETS_PEA3_N	activity, induced	transcription, induced			8495	2	0	0		
NPHS1	Cell adhesion; Immunoglobulin superfamily; Membrane protein, integral	O60500	4868	NPHS1	19q13.1	human	T1120	PHOSPHORYLATION	18507016	EYEESQWtGERDTQS		molecular association, regulation		ARRB2(INDUCES)		18410831	1	0	0	PICK1 and PKCa are also in this complex	
MDM2	EC 6.3.2.-; EC 6.3.2.19; Inhibitor protein; Ligase; UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase	Q00987	4193	MDM2	12q14.3-q15	human	S240	PHOSPHORYLATION	454919	GDWLDQDsVSDQFSV		activity, induced				4379	3	1	0	promotes p53 degradation	
PDGFRB	EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Protein kinase, TK; Protein kinase, tyrosine (receptor)	P09619	5159	PDGFRB	5q33.1	human	Y716	PHOSPHORYLATION	447524	RPPSAELySNALPVG	Pkinase_Tyr	activity, induced; molecular association, regulation		GRB7(INDUCES); Grb2(INDUCES)		1230; 2523	5	1	2		
KNG1	Cell adhesion; Contractile protein; Inhibitor protein; Motility/polarity/chemotaxis; Secreted; Secreted, signal peptide	P01042	3827	KNG1	3q27	human	S390	PHOSPHORYLATION	5024714	PGFSPFRsSRIGEIK	Bradykinin	protein processing				5014007	1	0	0	inhibits cleavage by kallikrein in vitro	
SIRT2	DEACETYLASE; Deacetylase; EC 3.5.1.-	Q8IXJ6	22933	SIRT2	19q13	human	S368	PHOSPHORYLATION	482809	PNPSTSAsPKKSPPP		enzymatic activity, inhibited	cell motility, altered; cell adhesion, altered; cell growth, altered			2451822; 11815	4	12	0	hyperphosphorylated during mitotic arrest;  ;  delay in cell growth of S368E mutant was observed; cell cycle-regulated phosphorylation	
ATP4A	EC 3.6.3.10; Energy Metabolism - oxidative phosphorylation; Hydrolase; Membrane protein, integral; Membrane protein, multi-pass	P20648	495	ATP4A	19q13.1	human	Y10	PHOSPHORYLATION	484290	KAENYELySVELGPG	H-K_ATPase_N	protein conformation				8543	2	0	15	Structure indicates tyrosine sequential phosphorylation at Y10 and subsequent Y7 which may induce activation of ATP4A.  	
DAPP1	Adaptor/scaffold	Q9UN19	27071	DAPP1	4q25-q27	human	Y139	PHOSPHORYLATION	448325	KVEEPSIyESVRVHT		activity, induced; molecular association, regulation; intracellular localization; phosphorylation	cytoskeletal reorganization	SH2D1B(NOT_REPORTED); PLCG2(INDUCES)		1377; 4524; 1378; 27932900	6	11	332	Rac1 activation, JNK phosphorylation	
Rb	Nuclear receptor co-regulator; Transcription, coactivator/corepressor; Tumor suppressor	P13405	19645	Rb1		mouse	T364	PHOSPHORYLATION	450023	DEEANVVtPHTPVRT		molecular association, regulation		E2F1(DISRUPTS)		1258	1	4	0		
SF1	RNA binding protein; RNA splicing; Spliceosome; Transcription, coactivator/corepressor	Q15637-2	7536	SF1	11q13	human	S82	PHOSPHORYLATION	452435	NPEDRSPsPEPIYNS		molecular association, regulation	RNA splicing, altered	U2AF2(INDUCES)		8058	1	45	12	facilitates formation of the SF1-U2AF-RNA complex	
claudin 16	Cell adhesion; Membrane protein, integral; Membrane protein, multi-pass	Q91Y55	155268	Cldn16		rat	T225	PHOSPHORYLATION	11555105	YKAPRTEtAKMYAVD		intracellular localization				11424228	1	0	0		
gephyrin	Adaptor/scaffold; EC 2.10.1.1; EC 2.7.7.75	Q8BUV3	268566	Gphn		mouse	S270	PHOSPHORYLATION	2020113	LSTTPSEsPRAQATS		protein degradation; intracellular localization				17675044	3	11	2	dephosphorylation of gephyrin facilitates postsynaptic cluster formation	
ezrin	Cytoskeletal protein; Motility/polarity/chemotaxis	P31977	54319	Ezr		rat	T567	PHOSPHORYLATION	448104	QGRDKYKtLRQIRQG	ERM		cytoskeletal reorganization			2506307	37	3	15		
JunB	Motility/polarity/chemotaxis; Transcription factor	P24898	24517	Junb		rat	T150	PHOSPHORYLATION	1814004	LHKMNHVtPPNVSLG	Jun	protein degradation	cell cycle regulation; transcription, altered			1813900	1	0	0	Phosphorylation promoted degradation during the G2-M transition.  JunB inhibition of cyclin D1 transcription is relieved by JunB protein degradation.	
Mnk2	EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, CAMK; Protein kinase, Ser/Thr (non-receptor); Translation	Q8CDB0	17347	Mknk2		mouse	T244	PHOSPHORYLATION	447640	GDCSPIStPELLTPC	Pkinase	enzymatic activity, induced				6207	1	1	0		
Cx43	Channel, misc.; Membrane protein, integral; Membrane protein, multi-pass; Motility/polarity/chemotaxis	Q6TYA7		GJA1		rabbit	S369	PHOSPHORYLATION	459208	RPSSRASsRASSRPR		intracellular localization				2831778	12	7	2	ischemia induces changes in the pattern of the Cx43 membrane distribution 	
CUL5	Ubiquitin conjugating system	Q9JJ31	64624	Cul5		rat	S730	PHOSPHORYLATION	963800	MKMRKKIsNAQLQTE	Cullin_Nedd8		cytoskeletal reorganization; cell growth, altered			762742	5	0	0	S730 phosphorylation may regulate angiogenisis.	
IRS1	Adaptor/scaffold; Motility/polarity/chemotaxis	P35570	25467	Irs1		rat	Y939	PHOSPHORYLATION	448700	EETGSEEyMNMDLGP		molecular association, regulation		PIK3R1(INDUCES)		3512	2	3	46		
Sam68	RNA binding protein	Q60749	20218	Khdrbs1		mouse	T84	PHOSPHORYLATION	449878	TVVGSAPtPLLPPSA		activity, induced	translation, altered			2423	1	1	1	regulates splicing	
TIE2	EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Protein kinase, TK; Protein kinase, tyrosine (receptor)	Q02763	7010	TEK	9p21	human	S1119	PHOSPHORYLATION	453441	TYAGIDCsAEEAA__		enzymatic activity, induced				7803	0	1	0	personal communication from Dr Chris Kontos , Duke University	
NFAT1	DNA binding protein; Transcription factor	Q60591	18019	Nfatc2		mouse	S365	PHOSPHORYLATION	449627	EQEERRNsAPESILL			transcription, inhibited			1188	0	6	6		
p53	Activator protein; DNA binding protein; Motility/polarity/chemotaxis; Nuclear receptor co-regulator; Transcription factor; Tumor suppressor	P04637	7157	TP53	17p13.1	human	S315	PHOSPHORYLATION	447530	LPNNTSSsPQPKKKP		activity, induced; protein degradation; molecular association, regulation; intracellular localization; protein conformation; activity, inhibited	cell cycle regulation; apoptosis, altered; apoptosis, inhibited; transcription, induced; transcription, altered; cell growth, altered	Pin1(INDUCES)	DNA(INDUCES)	7301; 18378520; 6046; 729; 7225; 7991115; 15658724; 5297; 6045; 7187; 4798; 6454	37	16	7		
GABBR2	GPCR, family 3; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR	O88871	83633	Gabbr2		rat	S892	PHOSPHORYLATION	450809	EHIQRRLsLQLPILH		activity, induced; protein stabilization				3067; 3066	2	2	0	Phosphorylation leads to the desensitization of rectifying K(+) channels (Kir3.1 + 3.2).	
ER-alpha	DNA binding protein; Nuclear receptor	P19785	13982	Esr1		mouse	S122	PHOSPHORYLATION	448101	LHPPPQLsPFLHPHG	Oest_recep		transcription, altered			3712	73	2	0	A reduction of basal transcriptional activity was observed when S122 was mutated. The effect of the replacement was increased by the introduction of mutations into AF-2 in the hormone binding domain. Optimum phosphorylation of S122 is dependent on the phosphorylation of S298.	
PDCD5	Apoptosis	O14737	9141	PDCD5	19q13.11	human	S119	PHOSPHORYLATION	452536	NRRKVMDsDEDDDY_	Terminase_4		apoptosis, induced; cell adhesion, altered			9721207	1	38	257		
C/EBP-beta	DNA binding protein; Motility/polarity/chemotaxis; Transcription factor	P21272	24253	Cebpb		rat	S185	PHOSPHORYLATION	455886	LSTSSSSsPPGTPSP			transcription, altered		DNA(INDUCES)	8352	8	6	0		
IGFBP1	Secreted; Secreted, signal peptide	P08833	3484	IGFBP1	7p13-p12	human	S194	PHOSPHORYLATION	451660	LAKAQETsGEEISKF	Thyroglobulin_1	activity, induced; molecular association, regulation		IGF1(INDUCES)		4641413; 14081202	5	5	0		
Cx43	Channel, misc.; Membrane protein, integral; Membrane protein, multi-pass; Motility/polarity/chemotaxis	P08050	24392	Gja1		rat	S262	PHOSPHORYLATION	450694	SPSKDCGsPKYAYFN			cell growth, altered			3063	14	6	4	Phosphorylation inhibits DNA synthesis irrespectively of cell-cell contact or coupling.	
LIP8	Cell cycle regulation	Q8N137	116840	CNTROB	17p13.1	human	S45	PHOSPHORYLATION	27565614	LYASLRLsRQAEATA			cell motility, inhibited			27565307	1	0	0		
IKKB	EC 2.7.11.10; KINASE; Kinase, protein; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor)	O14920	3551	IKBKB	8p11.2	human	S733	PHOSPHORYLATION	5014908	TVREQDQsFTALDWS	IKKbetaNEMObind	molecular association, regulation		IKK-gamma(DISRUPTS)		5007912	1	0	0		
NDEL1	Microtubule binding protein; Protease	Q9GZM8	81565	NDEL1	17p13.1	human	S198	PHOSPHORYLATION	474508	TRKSAPSsPTLDCEK	NUDE_C	molecular association, regulation; intracellular localization		PAFAH1B1(INDUCES)		9081	3	11	0		
vimentin	Cytoskeletal protein; Motility/polarity/chemotaxis	P08670	7431	VIM	10p13	human	S56	PHOSPHORYLATION	451514	SRSLYASsPGGVYAT	Filament_head; DUF2464	molecular association, regulation; intracellular localization; phosphorylation	cytoskeletal reorganization	SLC6A4(INDUCES); Cas-L(DISRUPTS); vimentin(DISRUPTS)		2531314; 7543512; 2576200	19	42	220	promotes PAK1 T423 phosphorylation	
STAT1	DNA binding protein; Transcription factor	P42225	20846	Stat1		mouse	S727	PHOSPHORYLATION	447753	TDNLLPMsPEEFDEM	STAT1_TAZ2bind	activity, induced; protein degradation; molecular association, regulation	cell cycle regulation; transcription, induced; transcription, altered; cell growth, altered	BTRC(INDUCES)		6271032; 4843010; 2670112; 4248210; 5713; 1281; 5309429; 2745108	79	9	82		
CDK5R2	Protein kinase, regulatory subunit	Q13319	8941	CDK5R2	2q35	human	T84	PHOSPHORYLATION	4697544	KKGSKKVtPKPASTG	CDK5_activator	intracellular localization				25083305	1	5	0	CDK5R2 S8 in its unphosphorylated form accumulates at the perinuclear region and T84 plays a role in the nuclear localization of CDK5R2.	
Notch 2	Membrane protein, integral; Motility/polarity/chemotaxis; Receptor, misc.	Q9QW30	29492	Notch2		rat	S2078	PHOSPHORYLATION	450165	PPGTVLTsALSPVLC		activity, induced	cell differentiation, altered			2783	1	0	0		
Rap1GAP	GTPase activating protein, Ras; Motility/polarity/chemotaxis	XP_233609	313644	Rap1gap		rat	S530	PHOSPHORYLATION	3190708	PFGSRRSsAIGIENI			cytoskeletal reorganization			6804215	1	11	24	controls dendritic spine morphology	
PML	Transcription factor; Tumor suppressor; Ubiquitin conjugating system	P29590	5371	PML	15q22	human	S561	PHOSPHORYLATION	6835503	ERVVVISsSEDSDAE	DUF3583	molecular association, regulation		SUMO1(INDUCES)		6829202	2	3	0		
GCH1	Cofactor and Vitamin Metabolism - folate biosynthesis; EC 3.5.4.16; Hydrolase	P22288	29244	Gch1		rat	T103	PHOSPHORYLATION	10428810	FTKGYQEtISDVLND	MAPKK1_Int	enzymatic activity, induced				10353908	1	0	0		
KCNMA1 iso4	Channel, potassium; Endoplasmic reticulum; Membrane protein, integral; Membrane protein, multi-pass	Q08460-4	16531	Kcnma1		mouse	S722	PHOSPHORYLATION	18264900	GRSERDCsCMSGRVR		activity, induced				18021004	1	0	0	abolishes inhibition resulting from AMPK phosphorylation (of another site, presumably)	
HER3	EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Protein kinase, TK; Protein kinase, tyrosine (receptor)	Q62799	29496	Erbb3		rat	Y1286	PHOSPHORYLATION	449858	CPAAEQGyEEMRAFQ		molecular association, regulation; phosphorylation		PIK3CB(INDUCES); PIK3R1(INDUCES)		1836	13	4	116	induces phosphorylation of Akt1.	
ADD1	Cytoskeletal protein; Motility/polarity/chemotaxis	Q63028	24170	Add1		rat	S714	PHOSPHORYLATION	449828	GSPGKSPsKKKKKFR		intracellular localization	cytoskeletal reorganization			2346	4	0	0		
CUTL1	DNA binding protein; Membrane protein, integral; Transcription factor	P39880	1523	CUX1	7q22.1	human	S1270	PHOSPHORYLATION	460701	YQQKPYPsPKTIEDL	Homeobox		transcription, inhibited			7781	1	8	0		
p27Kip1	Cell cycle regulation; Inhibitor protein; Protein kinase, regulatory subunit	P46414	12576	Cdkn1b		mouse	T170	PHOSPHORYLATION	6058800	QNKRANRtEENVSDG		intracellular localization				6011127	2	0	0	Cytoplasmic p27 is unable to inhibit Cdk2 kinase activity.	
claspin	Actin binding protein; Cell cycle regulation	Q9HAW4	63967	CLSPN	1p34.2	human	S945	PHOSPHORYLATION	455335	EELLNLCsGKFTSQD		molecular association, regulation		Chk1(INDUCES)		4600	1	0	0		
BAD	Apoptosis	Q61337	12015	Bad		mouse	S170	PHOSPHORYLATION	447864	KGLPRPKsAGTATQM	Bcl-2_BAD		cell cycle regulation; cell growth, inhibited; apoptosis, inhibited			2348; 25255521	6	8	3		
BRAF	EC 2.7.1.37; EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, Ser/Thr (non-receptor); Protein kinase, TKL	P15056	673	BRAF	7q34	human	T401	PHOSPHORYLATION	452246	STTGLSAtPPASLPG		molecular association, regulation; enzymatic activity, inhibited	cell growth, altered	RAF1(DISRUPTS)		17675002; 12025500	2	9	10		
TRIP6	Adaptor/scaffold; Motility/polarity/chemotaxis; Nuclear receptor co-regulator	Q9Z1Y4	22051	Trip6		mouse	Y55	PHOSPHORYLATION	456050	PLPPEHCyQPPGVPE		molecular association, regulation; intracellular localization	cytoskeletal reorganization	Crk(INDUCES); P130Cas(INDUCES)		6638; 14780526	5	3	40		
SREBP-1	DNA binding protein; Membrane protein, integral; Membrane protein, multi-pass; Transcription factor	P36956	6720	SREBF1	17p11.2	human	S434	PHOSPHORYLATION	6729302	PPPSDAGsPFQSSPL		protein degradation; molecular association, regulation; activity, inhibited; phosphorylation		FBXW7(INDUCES)		6331305	1	0	0		
JunB	Motility/polarity/chemotaxis; Transcription factor	P17275	3726	JUNB	19p13.2	human	T102	PHOSPHORYLATION	1814001	SNGVITTtPTPPGQY	Jun	activity, induced; molecular association, regulation	transcription, altered		DNA(INDUCES)	1813901	1	2	0	Phosphorylation of JunB increases cooperative binding with c-Maf to DNA.	
EpoR	EC 2.7.10.2; Membrane protein, integral; Receptor, cytokine	P19235	2057	EPOR	19p13.3-p13.2	human	Y426	PHOSPHORYLATION	449884	ASAASFEyTILDPSS		molecular association, regulation; activity, inhibited; phosphorylation	cell cycle regulation; apoptosis, induced; apoptosis, inhibited; cell growth, altered	STAT5A(INDUCES); SHIP(INDUCES); SOCS3(INDUCES); CISH(INDUCES)		8833; 5412; 8494; 6399; 8492; 2427	8	0	0		
ITPKA	Carbohydrate Metabolism - inositol phosphate; EC 2.7.1.127; Kinase, lipid; Motility/polarity/chemotaxis	P23677	3706	ITPKA	15q15.1	human	T311	PHOSPHORYLATION	451074	EHAQRAVtKPRYMQW	IPK	enzymatic activity, induced				3295	1	0	0		
NUT	Unknown function	Q86Y26	256646	NUT	15q14	human	S1031	PHOSPHORYLATION	13165100	LASKLSLsPREHPLS		intracellular localization				12482422	1	0	0	nuclear-cytoplasmic shuttling	
Bax	Apoptosis; Membrane protein, integral; Mitochondrial	Q07813	12028	Bax		mouse	S184	PHOSPHORYLATION	451017	VAGVLTAsLTIWKKM	TM	molecular association, regulation; intracellular localization	apoptosis, inhibited	MCL1(INDUCES); Bcl-xL(INDUCES)		3270	5	0	0		
MAPKAPK5	EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, CAMK; Protein kinase, Ser/Thr (non-receptor)	Q8IW41	8550	MAPKAPK5	12q24.13	human	S115	PHOSPHORYLATION	18704700	GELFHRIsQHRHFTE	Pkinase	intracellular localization	cytoskeletal reorganization			18668008	1	0	0	;  S115D mutant causes F-actin rearrangments; S115A mutant reduced the ability of MAPKAPK5 to activate p53-mediated transcription	
Src	EC 2.7.10.2; KINASE; Kinase, protein; Protein kinase, TK; Protein kinase, tyrosine (non-receptor)	P12931	6714	SRC	20q12-q13	human	S97	PHOSPHORYLATION	448232	VALYDYEsRTETDLS	SH3_1	enzymatic activity, inhibited				1279	1	0	0		
PRC1	Cell cycle regulation; Cytoskeletal protein; Microtubule binding protein; Motility/polarity/chemotaxis	O43663	9055	PRC1	15q26.1	human	T470	PHOSPHORYLATION	471795	LYGSAPRtPSKRRGL	MAP65_ASE1	intracellular localization	cell cycle regulation; cytoskeletal reorganization	PRC1(INDUCES)		1968301; 12083; 2858603	4	1	51		
merlin	Cytoskeletal protein; Motility/polarity/chemotaxis	Q63648	25744	Nf2		rat	S514	PHOSPHORYLATION	448282	DTDMKRLsMEIEKEK	ERM		cell growth, altered			2512004	21	17	1		
ADRA2A	GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR	P08913	150	ADRA2A	10q25.2	human	S296	PHOSPHORYLATION	456349	DALDLEEsSSSDHAE	7tm_1	activity, inhibited				6726	1	2	0		
NEDD4L	EC 6.3.2.-; EC 6.3.2.19; Ligase; UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase	Q96PU5	23327	NEDD4L	18q21	human	S342	PHOSPHORYLATION	453438	SSRLRSCsVTDAVAE		molecular association, regulation; activity, inhibited; phosphorylation		Smad3(DISRUPTS); ENaC-beta(DISRUPTS); ENaC-alpha(INDUCES)		4138; 12343103; 12284; 4207	8	7	59		
YAP1	Transcription, coactivator/corepressor	P46938	22601	Yap1		mouse	S79	PHOSPHORYLATION	3253276	RLRKLPDsFFKPPEP		molecular association, regulation	transcription, induced	TEAD1(INDUCES)		20834110	2	0	3		
SH2-B-beta	Adaptor/scaffold	Q62985-2	89817	Sh2b1		rat	S161	PHOSPHORYLATION	21336502	SLRSVGRsVRGSVRG		intracellular localization	cell motility, induced			27619352	2	0	2	disrupt localization at the plasma membrane.; macrophage migration	
ROMK	Channel, potassium; Membrane protein, integral; Membrane protein, multi-pass	P48048	3758	KCNJ1	11q24	human	S313	PHOSPHORYLATION	2461200	ATCQVRTsYVPEEVL	IRK	activity, induced; protein conformation; activity, inhibited				3309521; 2807231; 2807222	5	0	0		
PELI1	Adaptor/scaffold; EC 6.3.2.-; EC 6.3.2.19; Ligase; UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase	Q96FA3	57162	PELI1	2p13.3	human	T80	PHOSPHORYLATION	7388010	DQHSISYtLSRAQTV	Pellino	ubiquitination; enzymatic activity, induced				7228504	2	0	0		
HSP27	Chaperone; Motility/polarity/chemotaxis	Q00649		HSPB1		chicken	S77	PHOSPHORYLATION	448402	SPYGRALsELSSGIS	Cupredoxin_1	protein conformation				8559	21	6	31	Mutations mimicking phosphorylation of sites single (S15D) and in combination  form high and low molecular oligomers and affect chaperone activity in vitro. 	
MafA	DNA binding protein; Transcription factor	O57342		MAFA		quail	T57	PHOSPHORYLATION	456028	LSSTPLStPCSSVPS			cell differentiation, altered; transcription, altered			6333	6	1	0		
TH iso4	Amino Acid Metabolism - tyrosine; EC 1.14.16.2; Endoplasmic reticulum; Mitochondrial; Oxidoreductase; Vesicle protein	P07101-4	7054	TH	11p15.5	human	S29	PHOSPHORYLATION	448544	SYTPTPRsPRFIGRR	TOH_N	enzymatic activity, induced				7484	32	5	0		
ERG	DNA binding protein; Transcription factor	P11308-3	2078	ERG	21q22.3	human	S88	PHOSPHORYLATION	4712347	QVNGSRNsPDECSVA			transcription, induced			28761500	0	4	0		
NUP153	Nuclear export; Nucleoporin	P49790	9972	NUP153	6p22.3	human	T388	PHOSPHORYLATION	3191107	VYFKPSLtPSGEFRK	Nup153	molecular association, regulation		KPNB1(DISRUPTS)		9980430	2	4	4		
PKD1	Autophagy; EC 2.7.11.13; KINASE; Kinase, protein; Motility/polarity/chemotaxis; Protein kinase, CAMK; Protein kinase, Ser/Thr (non-receptor)	Q62101	18760	Prkd1		mouse	S744	PHOSPHORYLATION	448589	ARIIGEKsFRRSVVG	Pkinase	enzymatic activity, induced				3602; 2387; 830; 4684; 5506; 2440; 2449	48	7	14		
SLAP-130	Adaptor/scaffold	O15117	2533	FYB	5p13.1	human	Y651	PHOSPHORYLATION	452095	LDMGDEVyDDVDTSD	Ycf1	molecular association, regulation	cell motility, altered; cell adhesion, altered	SLP76(INDUCES)		15020906; 4036	3	3	22	promotes adhesion to ICAM-1; promotes cell migration	
POLM	DNA repair; EC 2.7.7.7; Transferase	Q9NP87	27434	POLM	7p13	human	T21	PHOSPHORYLATION	469478	SGDAASStPPSTRFP		molecular association, regulation; enzymatic activity, inhibited			DNA(DISRUPTS)	28723104	1	0	3		
GLT1	Membrane protein, integral; Membrane protein, multi-pass; Transporter	P31596	29482	Slc1a2		rat	S486	PHOSPHORYLATION	3053600	SVNVVGDsFGAGIVY	SDF	intracellular localization				8530	1	0	0		
ADORA3	GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR	P28647	25370	Adora3		rat	T318	PHOSPHORYLATION	450329	LDSNLEQtTE_____		receptor desensitization, altered				3050	1	0	0		
TNNI3	Actin binding protein; Motility/polarity/chemotaxis; Motor protein	P19429	7137	TNNI3	19q13.4	human	T129	PHOSPHORYLATION	6796400	ITEIADLtQKIFDLR	Troponin; DUF919	molecular association, regulation; protein conformation		C16orf82(INDUCES); TNC(INDUCES)		6702300	1	0	0		
GLI3	C2H2-type zinc finger protein; Transcription factor	P10071	2737	GLI3	7p13	human	S980	PHOSPHORYLATION	25780315	VHAPRRCsDGGAHGY		protein processing	transcription, inhibited			25779400	1	0	1		
HAND1	Cell development/differentiation; DNA binding protein; Transcription factor	Q64279	15110	Hand1		mouse	T107	PHOSPHORYLATION	12518701	PKKERRRtESINSAF	HLH	intracellular localization; protein conformation	cell differentiation, altered			12482412	1	0	0	release from nucleolus, dimerization	
RAF1	EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, Ser/Thr (non-receptor); Protein kinase, TKL	P04049	5894	RAF1	3p25	human	S301	PHOSPHORYLATION	455219	SSSPNNLsPTGWSQP		molecular association, regulation; intracellular localization; enzymatic activity, inhibited; enzymatic activity, induced		HRas(DISRUPTS)		4444; 4487; 1962902	4	13	62	phosphorylation of S289, S296, and S301 sustains and increases kinase activity	
ATF-2	C2H2-type zinc finger protein; Transcription factor	P15336	1386	ATF2	2q32	human	T69	PHOSPHORYLATION	448224	SVIVADQtPTPTRFL		activity, induced; protein stabilization	transcription, induced; transcription, altered			2333; 457; 4647100; 2332; 6403; 20655006; 2696	30	29	50		
SMRT	Nuclear receptor co-regulator; Transcription, coactivator/corepressor	Q9Y618	9612	NCOR2	12q24	human	S2522	PHOSPHORYLATION	465590	CSQYETLsDSE____		molecular association, regulation		TR-alpha(INDUCES)		8036	1	5	1	phosphorylation stabilizes SMRT interaction with TR-alpha in vitro	
catalase	Amino Acid Metabolism - tryptophan; Apoptosis; EC 1.11.1.6; Endoplasmic reticulum; Energy Metabolism - methane; Hydrolase; Mitochondrial; Oxidoreductase	P04040	847	CAT	11p13	human	Y231	PHOSPHORYLATION	450444	NANGEAVyCKFHYKT	Catalase	enzymatic activity, induced				2998	2	6	315		
PPAR-gamma	DNA binding protein; Nuclear receptor	P37238	19016	Pparg		mouse	K268	ACETYLATION	25780500	ARAILTGkTTDKSPF		molecular association, regulation		N-CoR1(INDUCES)		25712640	1	1	0	deacetylation mediates TZD-induced browning of white adipocytes enhancing expression of BAT genes 	
DISC1	Cell development/differentiation; Motility/polarity/chemotaxis	Q9NRI5	27185	DISC1	1q42.1	human	S58	PHOSPHORYLATION	18942701	GPGIGFLsPAVGTLF		molecular association, regulation; intracellular localization	transcription, induced	ATF-4(DISRUPTS)		27902337	2	0	0	S58-p is localized in the cytoplasm, dephosphorylated is nuclear localized. ATF-4 DISC1 binding region acts as a transcriptional repressor to the PDE4D9 promoter.; S58-p is localized in the cytoplasm, dephosphorylated is nuclear localized. ATF-4 DISC1 binding region acts as a transcriptional repressor to the PDE4D9 promoter.
	
IkB-alpha	DNA binding protein; Inhibitor protein	Q9Z1E3	18035	Nfkbia		mouse	S32	PHOSPHORYLATION	448203	LVDDRHDsGLDSMKD		protein degradation				5520; 5905	118	1	7		
PXN	Adaptor/scaffold; Cell adhesion; Cytoskeletal protein; Motility/polarity/chemotaxis	P49024	395832	PXN		chicken	Y118	PHOSPHORYLATION	448604	ASEEEHVySFPNKQK	Paxillin	molecular association, regulation	cytoskeletal reorganization	CDK6(INDUCES)		5011229	55	48	2522		
ERK1	EC 2.7.1.123; EC 2.7.11.24; KINASE; Kinase, protein; Protein kinase, CMGC; Protein kinase, Ser/Thr (non-receptor)	P21708	50689	Mapk3		rat	Y205	PHOSPHORYLATION	447543	HTGFLTEyVATRWYR	Pkinase; YukC	activity, induced; intracellular localization; enzymatic activity, induced	translation, altered; cell growth, altered			6295; 4862613; 3764; 5955619; 7472; 19016901; 7848; 13788306; 7910522; 5718	1014	73	3510	regulate cell proliferation in dentate gyrus following ischemia;  phenylphrine induces protein synthesis; colocalized in glucose induced filipodia extensions, leading to insulin secretion	
TAB2	Adaptor/scaffold	Q9NYJ8	23118	TAB2	6q25.1	human	S423	PHOSPHORYLATION	456007	SAASRNMsGQVSMGP		intracellular localization				6569	1	0	0		
MLK3	EC 2.7.11.25; KINASE; Kinase, protein; Protein kinase, Ser/Thr (non-receptor); Protein kinase, TKL	Q16584	4296	MAP3K11	11q13.1-q13.3	human	S674	PHOSPHORYLATION	448790	PGRERGEsPTTPPTP			apoptosis, inhibited			1954	2	0	0		
BKR2	GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR	P30411	624	BDKRB2	14q32.1-q32.2	human	Y347	PHOSPHORYLATION	452100	RKKSWEVyQGVCQKG		activity, induced; phosphorylation				6971	3	2	0	 this increases ERK activation when stimulated with EGF+isoproterenol+bradykinin as compared to the WT BKR2.; Mutation of both tyrosines to phenylalanines prevents Gi protein-mediated cAMP accumulation induced by bradykinin	
C5aR	GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR	P21730	728	C5AR1	19q13.3-q13.4	human	S314	PHOSPHORYLATION	450055	FQGRLRKsLPSLLRN		molecular association, regulation		ARRB1(INDUCES); ARRB2(INDUCES)		1994	2	0	0		
Bim	Apoptosis	O54918	12125	Bcl2l11		mouse	S55	PHOSPHORYLATION	454235	GDRCPHGsPQGPLAP		protein degradation; molecular association, regulation	apoptosis, altered; apoptosis, inhibited	Bax(DISRUPTS)		2915501; 4230; 9090	5	0	0		
ADCY6	Adenylyl cyclase; EC 4.6.1.1; Lyase; Membrane protein, integral; Membrane protein, multi-pass; Nucleotide Metabolism - purine	AAA40678	25289	Adcy6		rat	T931	PHOSPHORYLATION	455530	HAQQVEStARLDFLW		enzymatic activity, inhibited				3690	1	0	0		
CTNNB1	Actin binding protein; Cell adhesion; Motility/polarity/chemotaxis; Nuclear receptor co-regulator; Transcription factor	P35222	1499	CTNNB1	3p21	human	T120	PHOSPHORYLATION	6406005	QFDAAHPtNVQRLAE	HEAT_2; RIX1	intracellular localization	cell growth, inhibited; transcription, induced; cell motility, inhibited; transcription, inhibited			25227645; 6366210	2	0	0		
SGK1	EC 2.7.11.1; KINASE; Kinase, protein; Motility/polarity/chemotaxis; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor)	Q06226	29517	Sgk1		rat	T256	PHOSPHORYLATION	448431	EHNGTTStFCGTPEY	Pkinase	enzymatic activity, induced				1268	12	0	0		
Cx43	Channel, misc.; Membrane protein, integral; Membrane protein, multi-pass; Motility/polarity/chemotaxis	P17302	2697	GJA1	6q22.31	human	S255	PHOSPHORYLATION	448852	HATSGALsPAKDCGS		intracellular localization				4346	13	13	1		
Cdc25C	EC 3.1.3.48; Motility/polarity/chemotaxis; PHOSPHATASE; Protein phosphatase, dual-specificity	P30309	398119	cdc25c-b		frog	T48	PHOSPHORYLATION	448419	FSPEQPLtPVTDLAV		molecular association, regulation	cell cycle regulation	CKS1(INDUCES); Pin1(INDUCES)		7397602	3	2	10	Pin1 and CKS1 compete for binding to phosphorylated T48 Cdc25C.	
Oct4	DNA binding protein; Transcription factor	Q01860	5460	POU5F1	6p21.31	human	S12	PHOSPHORYLATION	18496900	LASDFAFsPPPGGGG		protein stabilization; molecular association, regulation	transcription, altered	Pin1(INDUCES)		18410819	1	0	0		
HIF2A	DNA binding protein; Transcription factor	Q99814	2034	EPAS1	2p21-p16	human	T324	PHOSPHORYLATION	471073	VWLETQGtVIYNPRN	PAS_3	molecular association, regulation	apoptosis, induced; transcription, altered	SP1(DISRUPTS)		9037	1	0	0		
MRCKA	EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor)	Q5VT25	8476	CDC42BPA	1q42.11	human	T403	PHOSPHORYLATION	12612503	HLPFVGFtYTSSCVL	Pkinase_C	enzymatic activity, induced	cytoskeletal reorganization			12482237	1	0	0		
SLC24A2	Membrane protein, integral; Membrane protein, multi-pass; Transporter	O54701	84550	Slc24a2		rat	S504	PHOSPHORYLATION	471068	PDVRKPAsKKFFPIT		activity, induced				9038	1	0	0	Mutation to alanine of T476 and either T166 or S504 (or possibly both) eliminates PDBu-induced enhancement (PIE) on the Na(+)/Ca(2+)+K(+) exchanger.	
MyoD	DNA binding protein; RNA splicing; Transcription factor	P10085	17927	Myod1		mouse	S5	PHOSPHORYLATION	470072	___MELLsPPLRDID	Basic	protein degradation; molecular association, regulation; intracellular localization	cell cycle regulation; transcription, altered	HDAC1(INDUCES); PCAF(DISRUPTS)	DNA(DISRUPTS)	8938; 8661	2	0	0		
ALK	EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Protein kinase, TK; Protein kinase, tyrosine (receptor)	Q9UM73	238	ALK	2p23	human	Y1604	PHOSPHORYLATION	447828	TAPGAGHyEDTILKS		molecular association, regulation	cell cycle regulation	PLCG1(INDUCES)		826	3	3	50	The complex formation leads to the tyrosine phosphorylation and activation of PLC-gamma.	
ER-beta	DNA binding protein; Nuclear receptor	O08537	13983	Esr2		mouse	Y488	PHOSPHORYLATION	450057	CKNVVPVyDLLLEML	Hormone_recep		transcription, induced			1074	1	0	0		
AQP0	Channel, misc.; Membrane protein, integral; Membrane protein, multi-pass	P09011	25480	Mip		rat	S233	PHOSPHORYLATION	450116	KSVSERLsILKGARP		intracellular localization				2807218	4	8	0		
ATF-2	C2H2-type zinc finger protein; Transcription factor	P15336	1386	ATF2	2q32	human	T71	PHOSPHORYLATION	448225	IVADQTPtPTRFLKN		activity, induced; protein stabilization	cell cycle regulation; transcription, induced; transcription, altered; cell growth, altered			4647100; 5410116; 6403; 20655006; 2333; 457; 2332; 2696	49	28	36		
RasGRF1	Guanine nucleotide exchange factor, Ras	Q13972	5923	RASGRF1	15q24.2	human	S929	PHOSPHORYLATION	448487	KEKYRRMsLASAGFP	RasGEF_N	activity, induced				686	3	0	0	necessary but not sufficient for RasGRF1 activation	
FGF2	Activator protein; Motility/polarity/chemotaxis	P15655	14173	Fgf2		mouse	Y81	PHOSPHORYLATION	13823202	KGVCANRyLAMKEDG	FGF	intracellular localization				13359105	1	1	0	essential for FGF2 secretion 	
myocardin	Cell development/differentiation; Transcription factor	Q8VIM5	214384	Myocd		mouse	S458	PHOSPHORYLATION	3627512	HFGSTSSsPPISPAS			transcription, inhibited			6856	1	0	0		
MST1	Autophagy; EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, STE; Protein kinase, Ser/Thr (non-receptor)	Q13043	6789	STK4	20q11.2-q13.2	human	T183	PHOSPHORYLATION	447925	DTMAKRNtVIGTPFW	Pkinase	intracellular localization; enzymatic activity, induced				1321	9	0	5		
Kv1.2	Channel, potassium; Membrane protein, integral; Membrane protein, multi-pass	P16389	3737	KCNA2	1p13	human	Y132	PHOSPHORYLATION	452037	MFREDEGyIKEEERP		activity, inhibited				4173	3	0	0	this site is required for channel suppression and channel endocytosis	
restin	Cytoskeletal protein	Q9JK25	65201	Rsn		rat	S309	PHOSPHORYLATION	4769827	TPASLKRsPSASSLS		molecular association, regulation; protein conformation		TUBA1C(DISRUPTS)		15031338	1	4	1		
NHERF	Adaptor/scaffold; Motility/polarity/chemotaxis	O14745	9368	SLC9A3R1	17q25.1	human	S340	PHOSPHORYLATION	455753	RAHQKRSsKRAPQMD	EBP50_C-term	molecular association, regulation		CFTR(INDUCES)		12061	3	1	12		
K8	Cytoskeletal protein	P05787	3856	KRT8	12q13	human	S291	PHOSPHORYLATION	3081700	IKYEELQsLAGKHGD	Filament; Fib_alpha; E2R135; Spc7; Myosin_tail_1	protein conformation				8377	1	1	2	Conformational change in K8 gene intermediate filaments. 	
HS1	Adaptor/scaffold; Motility/polarity/chemotaxis	P49710	15163	Hcls1		mouse	Y405	PHOSPHORYLATION	451636	DEDAEGDyEDVLEPE		molecular association, regulation; intracellular localization		ITK(INDUCES)		12023001; 3743	8	1	8		
claudin 1	Cytoskeletal protein; Membrane protein, integral; Membrane protein, multi-pass	Q5ZMG2	424910	CLDN1		chicken	T206	PHOSPHORYLATION	460032	YPKNAPStGKDYV__		activity, induced				7691	1	1	1	critical for proper heart asymmetric positioning in the chicken embryo	
EGFR	EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Protein kinase, TK; Protein kinase, tyrosine (receptor)	P00533	1956	EGFR	7p12	human	S1070	PHOSPHORYLATION	448051	DSFLQRYsSDPTGAL		receptor desensitization, altered; receptor internalization, altered				1060; 3881	10	2	6		
LATS2	EC 2.7.11.1; KINASE; Kinase, protein; Nuclear receptor co-regulator; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor)	Q7TSJ6	50523	Lats2		mouse	S830	PHOSPHORYLATION	10945601	HQRCLAHsLVGTPNY	Pkinase	enzymatic activity, induced	cell growth, altered			10296906	1	0	4		
LAT	Adaptor/scaffold; Membrane protein, integral	O54957	16797	Lat		mouse	Y136	PHOSPHORYLATION	447760	EDDYPNGyLVVLPDS		activity, induced; intracellular localization; phosphorylation	apoptosis, altered; cell differentiation, altered; apoptosis, induced; cell adhesion, altered; cell growth, altered	Fyn(INDUCES)		2665600; 1713; 4228; 14654307; 970001; 1712	13	0	1		
PDGFRA	EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Protein kinase, TK; Protein kinase, tyrosine (receptor)	P16234	5156	PDGFRA	4q12	human	Y754	PHOSPHORYLATION	448439	ERKEVSKySDIQRSL	Pkinase_Tyr	molecular association, regulation		SHP-2(INDUCES)		6024; 1226	3	3	34		
CFTR	Channel, chloride; EC 3.6.3.49; Hydrolase; Membrane protein, integral; Membrane protein, multi-pass; Transporter	P26361	12638	Cftr		mouse	S422	PHOSPHORYLATION	3333404	SNGDRKHsSDENNVS		protein conformation				11424200	2	1	0	in vitro	
SRF	Motility/polarity/chemotaxis; Transcription factor	P11831	6722	SRF	6p21.1	human	S162	PHOSPHORYLATION	460665	LRRYTTFsKRKTGIM	SRF-TF		transcription, inhibited			10430801; 7772	2	0	0		
GLUT2	Membrane protein, integral; Membrane protein, multi-pass; Transporter	P12336	25351	Slc2a2		rat	S503	PHOSPHORYLATION	451346	EFRKKSGsAPPRKAT		activity, inhibited				3556	1	0	0	Phosphorylation reduces the initial rate of 3-O-methyl glucose uptake.	
MEK1	EC 2.7.12.2; KINASE; Kinase, protein; Protein kinase, STE; Protein kinase, dual-specificity	Q01986	170851	Map2k1		rat	S218	PHOSPHORYLATION	448514	VSGQLIDsMANSFVG	Pkinase	enzymatic activity, induced				710; 1810	90	5	54		
KOR-1	GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR	P33534	18387	Oprk1		mouse	S369	PHOSPHORYLATION	449609	NTVQDPAsMRDVGGM		receptor desensitization, altered; phosphorylation				3054; 10353930	7	0	0	stimulates phosphorylation of GIRK1 Y12 in cells treated with U50,488	
Met	EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Protein kinase, TK; Protein kinase, tyrosine (receptor)	P16056	17295	Met		mouse	Y1311	PHOSPHORYLATION	450189	EYCPDALyEVMLKCW	Pkinase_Tyr	molecular association, regulation	cell motility, altered; cytoskeletal reorganization	Shc1(INDUCES); PIK3C2A(INDUCES); Gab1(INDUCES); Grb2(INDUCES)		2849; 2850	5	1	4		
Bcl-2	Apoptosis; Autophagy; Membrane protein, integral	P10415	596	BCL2	18q21.3	human	T74	PHOSPHORYLATION	448632	ARTSPLQtPAAPGAA		protein stabilization; ubiquitination	apoptosis, altered; apoptosis, induced; apoptosis, inhibited			4647112; 1830; 4647110	4	0	0		
RAF1	EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, Ser/Thr (non-receptor); Protein kinase, TKL	P04049	5894	RAF1	3p25	human	S497	PHOSPHORYLATION	3082308	ATVKSRWsGSQQVEQ	Pkinase_Tyr	enzymatic activity, induced				8397; 7324122	2	1	0		
ezrin	Cytoskeletal protein; Motility/polarity/chemotaxis	P15311	7430	EZR	6q25.3	human	T567	PHOSPHORYLATION	448104	QGRDKYKtLRQIRQG	ERM	activity, induced; molecular association, regulation; intracellular localization; protein conformation; phosphorylation	cell differentiation, altered; cell motility, altered; cytoskeletal reorganization; cell adhesion, altered	moesin(DISRUPTS); ezrin(DISRUPTS); ACTA1(INDUCES)		6096; 6927; 2461602; 3361000; 7318600; 4566; 4648; 4894705; 671; 6011115	37	3	15		
AML3	DNA binding protein; Transcription factor	Q13950	860	RUNX2	6p21	human	S312	PHOSPHORYLATION	10892802	SYLSQMTsPSIHSTT			transcription, induced			10353940	6	1	0		
PXN iso2	Adaptor/scaffold; Cell adhesion; Cytoskeletal protein; Motility/polarity/chemotaxis	P49023-2	5829	PXN	12q24.31	human	S126	PHOSPHORYLATION	450227	SFPNKQKsAEPSPTV	Paxillin		cell cycle regulation; carcinogenesis, altered; transcription, altered			15022718	6	14	4	regulates Erk1/2-induced cell proliferation and transcription	
CAMKK2	Autophagy; EC 2.7.11.17; KINASE; Kinase, protein; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor)	Q96RR4	10645	CAMKK2	12q24.2	human	S511	PHOSPHORYLATION	2861414	RREERSLsAPGNLLT		phosphorylation				2852666	1	11	15	increases autophosphorylation	
FcGR2B	Cell surface; Membrane protein, integral	P08101	14130	Fcgr2		mouse	Y309	PHOSPHORYLATION	448507	EAENTITySLLKHPE		activity, induced; phosphorylation				8503	3	2	1	regulates Ca(2+) influx, ERK activation, SHIP phosphorylation	
CDK9	EC 2.7.11.22; EC 2.7.11.23; KINASE; Kinase, protein; Nuclear receptor co-regulator; Protein kinase, CMGC; Protein kinase, Ser/Thr (non-receptor)	P50750	1025	CDK9	9q34.1	human	T186	PHOSPHORYLATION	450950	NSQPNRYtNRVVTLW	Pkinase	protein stabilization; molecular association, regulation; enzymatic activity, induced	transcription, altered	TEAD1(INDUCES); EDG-1(INDUCES)	RNA(INDUCES)	27127700; 20655014; 6373; 3221; 18837502	11	13	9	7SK RNA; T186 phosporylation is important for CDK9-7SK interaction in vitro and in vivo.  ; Phosphorylation of T186 of Cdk9 is required for P-TEFb kinase activity and formation of 7SK-HEXIM1-P-TEFB complex. ; decrease in phosphorylation precedes Cdk9 degradation 	
NRF2	DNA binding protein; Transcription factor	Q60795	18024	Nfe2l2		mouse	S335	PHOSPHORYLATION	18258505	MEFNDSDsGISLNTS		protein degradation; molecular association, regulation		BTRC(INDUCES)		18021029	3	0	0		
p21Cip1	Cell cycle regulation; Inhibitor protein	P38936	1026	CDKN1A	6p21.2	human	S146	PHOSPHORYLATION	447836	GRKRRQTsMTDFYHS		protein stabilization; molecular association, regulation; intracellular localization	cell growth, altered			5956; 1201; 3361011	7	0	0		
P2X7	Channel, ligand-gated; Membrane protein, integral; Membrane protein, multi-pass; Receptor, misc.	Q64663	29665	P2rx7		rat	Y550	PHOSPHORYLATION	2179300	SKLRHCAyRSYATWR			cytoskeletal reorganization			2925	1	0	0		
PDE3B	EC 3.1.4.17; Membrane protein, integral; Membrane protein, multi-pass; Nucleotide Metabolism - purine; Phosphodiesterase	Q63085	29516	Pde3b		rat	S302	PHOSPHORYLATION	449873	GKMFRRPsLPCISRE		molecular association, regulation; enzymatic activity, induced		14-3-3 beta(INDUCES)		2418; 2691	5	7	19		
Abi-1	Adaptor/scaffold; Motility/polarity/chemotaxis	Q8CBW3	11308	Abi1		mouse	Y213	PHOSPHORYLATION	449523	PPTVPNDyMTSPARL		molecular association, regulation	cell adhesion, altered	Abl(INDUCES)		18415118	3	25	709	;  enhances cell adhesion in Bcr-Abl expressing cells; induces the catalytic activity of c-Abl in vitro	
IRAK4	EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, Ser/Thr (non-receptor); Protein kinase, TKL	Q9NWZ3	51135	IRAK4	12q12	human	T345	PHOSPHORYLATION	2045325	KFAQTVMtSRIVGTT	Pkinase	protein conformation; enzymatic activity, induced				25785408; 25785409; 2852672	1	3	0		
SCN2A	Channel, sodium; Membrane protein, integral; Membrane protein, multi-pass	P04775	24766	Scn2a		rat	Y1497	PHOSPHORYLATION	1046202	MTEEQKKyYNAMKKL		activity, inhibited				970058	1	0	0		
MTMR2	Carbohydrate Metabolism - fructose and mannose; Cofactor and Vitamin Metabolism - riboflavin; Cofactor and Vitamin Metabolism - thiamine; EC 3.1.3.-; Motility/polarity/chemotaxis; Phosphatase (non-protein); Protein phosphatase, tyrosine (non-receptor)	Q13614	8898	MTMR2	11q22	human	S58	PHOSPHORYLATION	3195800	STSADNFsPDLRVLR		intracellular localization	signaling pathway regulation			18668207	2	9	0	 enhances EGF signaling; localization of S58A mutant to early endosomal structures results in dephosphorylation of PI(3)	
GNA15	G protein; G protein, heterotrimeric; G protein, heterotrimeric alpha G(q)	P30678	14676	Gna15		mouse	S334	PHOSPHORYLATION	11380904	QDGGRKGsRARRFFA	G-alpha	activity, induced				10303913	1	0	0	GNA15 receptor mediated PLC-B  activation 	
EphB2	EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Protein kinase, TK; Protein kinase, tyrosine (receptor)	P54763	13844	Ephb2		mouse	Y610	PHOSPHORYLATION	448327	IYIDPFTyEDPNEAV		molecular association, regulation; enzymatic activity, induced	cell adhesion, altered; cytoskeletal reorganization	NMDAR1(INDUCES); RASA1(INDUCES); Src(INDUCES)		4888107; 5264; 1052900; 8957	7	16	120		
PDK1	EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor)	Q9Z2A0	18607	Pdpk1		mouse	S532	PHOSPHORYLATION	5938009	TYYLMDPsGNAHKWC		enzymatic activity, inhibited				5930009	1	0	0		
C/EBP-alpha	DNA binding protein; Transcription factor	P05554	24252	Cebpa		rat	T226	PHOSPHORYLATION	449825	GHPTPPPtPVPSPHP		activity, inhibited	transcription, altered			7862	6	0	0	In 3T3L1 preadipocytes, mutation of T222/T226 to alanines increased transcription at CBE-containing promoter (as compared to WT C/EBP-alpha).  S230A had a similar effect as the double T->A mutation.  The triple alanine mutation had the highest transcription of the reporter gene.  S230A did not reduce T222/226 phosphorylation (although CHIR99021 inhibitor did).	
Cdc25A	EC 3.1.3.48; Motility/polarity/chemotaxis; PHOSPHATASE; Protein phosphatase, dual-specificity	P30304	993	CDC25A	3p21	human	S76	PHOSPHORYLATION	449340	SNLQRMGsSESTDSG		protein degradation; molecular association, regulation; ubiquitination; phosphorylation	cell cycle regulation	BTRC(INDUCES)		2952; 2527; 14146303; 3594; 2201; 4207603; 10353922	10	0	1		
GRF-1	GTPase activating protein, Rac/Rho; Motility/polarity/chemotaxis; Transcription factor	Q9NRY4	2909	ARHGAP35	19q13.3	human	S1236	PHOSPHORYLATION	7159801	PKPKPRPsITKATWE		activity, inhibited				6804206	2	1	0		
HSL	EC 3.1.1.79; Lipase	P15304	25330	Lipe		rat	S900	PHOSPHORYLATION	450193	GNSEPSDsPEMSQSM		enzymatic activity, induced				2431	1	0	0		
BLNK	Adaptor/scaffold	Q8WV28	29760	BLNK	10q23.2-q23.33	human	Y96	PHOSPHORYLATION	447719	EENADDSyEPPPVEQ		molecular association, regulation	transcription, altered	Nck2(INDUCES); PLCG2(INDUCES); PLCG1(INDUCES); Btk(INDUCES); VAV1(INDUCES)		827; 7669	4	1	0	Sites mutated alone and in combination (Y189,Y178and Y96) prevented binding of PLCG1 and mobization of Ca2+. For NF-AT transcriptional activity Y103,Y194 and Y205 residues were necessary.Tyrosine phosphoryation of BLNK induces MAPK activation. 



	
CAMK2B	EC 2.7.1.123; EC 2.7.11.17; KINASE; Kinase, protein; Protein kinase, CAMK; Protein kinase, Ser/Thr (non-receptor)	P08413	24245	Camk2b		rat	T287	PHOSPHORYLATION	450048	SMMHRQEtVECLKKF		molecular association, regulation; intracellular localization; phosphorylation; enzymatic activity, induced		RPT6(INDUCES); CAMK2A(INDUCES); SYN1(INDUCES); MARCKS(INDUCES); CAMK2B(INDUCES)		2669500; 14148606; 3999	13	10	106		
CBP	ACETYLTRANSFERASE; Acetyltransferase; DNA binding protein; EC 2.3.1.48; Motility/polarity/chemotaxis; Nuclear receptor co-regulator; Transcription, coactivator/corepressor	Q6JHU9	54244	Crebbp		rat	S301	PHOSPHORYLATION	448068	PQLASKQsMVNSLPA			transcription, induced			1333	1	0	0		
C/EBP-beta	DNA binding protein; Motility/polarity/chemotaxis; Transcription factor	P28033	12608	Cebpb		mouse	S64	PHOSPHORYLATION	456166	HERAIDFsPYLEPLA			transcription, inhibited			6605	7	0	1		
SLC6A1	Membrane protein, integral; Membrane protein, multi-pass; Transporter	P30531	6529	SLC6A1	3p25.3	human	Y107	PHOSPHORYLATION	11382801	LECSLGQyTSIGGLG	SNF	activity, induced; receptor internalization, altered; intracellular localization				10292914	1	0	0		
nNOS	Amino Acid Metabolism - arginine and proline; EC 1.14.13.39; Oxidoreductase	P29476	24598	Nos1		rat	S847	PHOSPHORYLATION	447886	SYKVRFNsVSSYSDS	Flavodoxin_1	enzymatic activity, inhibited				2531311; 1199	11	1	3		
Jun	Transcription factor	P05627	16476	Jun		mouse	K229	SUMOYLATION	2793916	HPRLQALkEEPQTVP	Jun; DUF3450		transcription, inhibited			2429105	5	0	0		
VEGFR2	EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Protein kinase, TK; Protein kinase, tyrosine (receptor)	P35918	16542	Kdr		mouse	Y1173	PHOSPHORYLATION	447901	AQQDGKDyIVLPMSE		receptor internalization, induced; molecular association, regulation; intracellular localization				21402201; 14821623	24	0	0	Syx, Rab13, and GRrb2 colocalize with phosphorylated 1173 VEGR2 at the leading edge in VEGF stimulated ECs.	
K19	Cytoskeletal protein	P08727	3880	KRT19	17q21.2	human	S35	PHOSPHORYLATION	449970	GVAFRAPsIHGGSGG			cytoskeletal reorganization			2530	2	6	102		
CTNND2	Actin binding protein; Motility/polarity/chemotaxis	O35927	18163	Ctnnd2		mouse	S357	PHOSPHORYLATION	4697626	IGTYATLsPTKRLVH		molecular association, regulation; intracellular localization	cytoskeletal reorganization	PSD-95(DISRUPTS); GRIP1(DISRUPTS)		14780512	1	2	0		
OBFC2B	Cell cycle regulation; DNA repair	Q9BQ15	79035	NABP2	12q13.3	human	T117	PHOSPHORYLATION	12526701	EPNPEYStQQAPNKA		protein stabilization			DNA(INDUCES)	27519605	2	0	0	single stranded DNA	
ATM	EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, ATYPICAL; Protein kinase, Ser/Thr (non-receptor)	Q62388	11920	Atm		mouse	S1899	PHOSPHORYLATION	467199	PANSDSEsENFLRCC			chromatin organization, altered			5930010	3	2	0		
LAT iso2	Adaptor/scaffold; Membrane protein, integral	O43561-2	27040	LAT	16p11.2	human	T155	PHOSPHORYLATION	451994	PSAPALStPGIRDSA	LAT	activity, inhibited				3907	1	0	11		
MOR-1	GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR	P35372	4988	OPRM1	6q24-q25	human	S377	PHOSPHORYLATION	447784	QNTRDHPsTANTVDR		receptor internalization, altered	signaling pathway regulation			18410825; 2831776	16	2	0	inhibitor of PKCE activation	
CK2-B	KINASE; Protein kinase, regulatory subunit	Q5SRQ6	1460	CSNK2B	6p21.3	human	S22	PHOSPHORYLATION	447647	SADVKMSsSEEVSWI		protein stabilization				5825	2	8	0		
IP3R1	Channel, calcium; Channel, ligand-gated; Membrane protein, integral; Membrane protein, multi-pass; Receptor, misc.	P11881	16438	Itpr1		mouse	S1588	PHOSPHORYLATION	450681	RNAARRDsVLAASRD		activity, induced				9274	8	26	2	Ca(2+) mobilization	
TLR3	Membrane protein, integral; Receptor, cytokine	O15455	7098	TLR3	4q35	human	Y759	PHOSPHORYLATION	450187	EQFEYAAyIIHAYKD	TIR	phosphorylation	transcription, altered			2103; 2653902	3	0	0	increases phosphorylation of some NFKB sites	
GRK2	EC 2.7.11.15; KINASE; Kinase, protein; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor)	Q99MK8	110355	Adrbk1		mouse	Y13	PHOSPHORYLATION	456872	AVLADVSyLMAMEKS			cell motility, altered			2425208	5	0	0		
ARHGAP12	GTPase activating protein, Rac/Rho	Q8C0D4	75415	Arhgap12		mouse	S238	PHOSPHORYLATION	451931	PNQGRPDsPVYANLQ			cell cycle regulation; cell motility, altered			2790302	0	33	727		
mAChR M2	GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR	P08172	1129	CHRM2	7q31-q35	human	T287	PHOSPHORYLATION	459103	KESSNDStSVSAVAS	7tm_1	receptor internalization, altered				7628	3	0	0	Mutation of S286 T287 S288 S290 to A caused a faster rate and a greater extent of receptor internalization after agonist stimulation (transients only, not observed in stables).  Mutation of all 8 sites prevented internalization (in both transients and stables).	
NPM1	RNA binding protein; Translation	P06748	4869	NPM1	5q35.1	human	K229	ACETYLATION	461146	SKGQESFkKQEKTPK	Nop14; TFIIF_alpha	molecular association, regulation; intracellular localization	transcription, altered	H3(INDUCES)		8156707	1	1	104	K212/215/229/230/257/267/292R  mutant	
TSC2 iso2	Cell cycle regulation; GTPase activating protein, misc.; Nuclear receptor co-regulator; Tumor suppressor	P49816-2	24855	Tsc2		rat	S1346	PHOSPHORYLATION	450212	QPLSKSSsSPELQTL		phosphorylation	apoptosis, altered; cell growth, altered			2659809; 2902	7	7	6		
B-Myb	DNA binding protein; Motility/polarity/chemotaxis; Transcription factor	P48972	17865	Mybl2		mouse	T447	PHOSPHORYLATION	452026	NSLTPKStPVKTLPF		activity, induced				3936	3	0	0		
PTPN3	EC 3.1.3.48; Motility/polarity/chemotaxis; Protein phosphatase, tyrosine (non-receptor)	P26045	5774	PTPN3	9q31	human	S359	PHOSPHORYLATION	451191	PAMRRSLsVEHLETK		molecular association, regulation		14-3-3 beta(INDUCES)		3393	1	5	1		
PLK4	EC 2.7.11.21; KINASE; Kinase, protein; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor)	O00444	10733	PLK4	4q28	human	S305	PHOSPHORYLATION	12122401	SSTSISGsLFDKRRL		intracellular localization	cell cycle regulation			12021320	2	1	0	enhances centriole amplification	
LPP	Adaptor/scaffold; Cytoskeletal protein; Motility/polarity/chemotaxis	Q8BFW7	210126	Lpp		mouse	Y297	PHOSPHORYLATION	463380	YTSNQGRyYEPYYAA			cell cycle regulation; cell motility, altered			2790302	0	2	27		
RNF12	EC 6.3.2.-; Ligase; Transcription, coactivator/corepressor; UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase	Q9NVW2	51132	RLIM	Xq13-q21	human	S215	PHOSPHORYLATION	18014966	QRRARSRsPDHRRTR		intracellular localization	cell motility, induced; apoptosis, inhibited			28722419	1	0	0	phosphorylated S214 (human) or S215 (murine) RNF12 is localized in nucleus;  shuttling of RNF12 is important for promoting cell motility and alveolar cell survival	
DVL2	Adaptor/scaffold; Motility/polarity/chemotaxis	O14641	1856	DVL2	17p13.1	human	T206	PHOSPHORYLATION	17301000	MTSELEStSLGDSDE	Dishevelled		cell cycle regulation			15754910	1	0	0		
TRPV1	Channel, cation; Membrane protein, integral; Membrane protein, multi-pass; Receptor, misc.	Q704Y3	193034	Trpv1		mouse	T371	PHOSPHORYLATION	455383	RHLSRKFtEWAYGPV		receptor desensitization, altered				8949	4	0	0		
TRPV5	Channel, cation; Membrane protein, integral; Membrane protein, multi-pass; Motility/polarity/chemotaxis	Q9XSM3		Trpv5		rabbit	S654	PHOSPHORYLATION	470109	YVEAFKCsDKEDGQE		activity, induced; intracellular localization				6337831; 2195472	3	0	0	CaR-dependent channel activation; inhibits caveolar endocytosis of TRPV5	
GATA1	DNA binding protein; Transcription factor	P17679	14460	Gata1		mouse	S178	PHOSPHORYLATION	451236	PFFSPTGsPLSSAAY		molecular association, regulation		LMO2(INDUCES)		8522	3	0	0		
PML	Transcription factor; Tumor suppressor; Ubiquitin conjugating system	P29590	5371	PML	15q22	human	S36	PHOSPHORYLATION	451469	PSEGRQPsPSPSPTE		sumoylation	apoptosis, altered			5354446	2	7	0	induces sumoylation	
MSK1	EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor)	O75582	9252	RPS6KA5	14q31-q32.1	human	S376	PHOSPHORYLATION	448216	EKLFQGYsFVAPSIL	Pkinase_C	enzymatic activity, induced				6119	20	12	35		
NPAT	Cell cycle regulation; Transcription regulation	Q14207	4863	NPAT	11q22-q23	human	S1100	PHOSPHORYLATION	2286403	VSFPNLDsPNVSSTL			transcription, induced			2285900	1	0	0	multiple sites deletion mutant	
PIAS1	EC 6.3.2.-; Nuclear receptor co-regulator; SUMO LIGASE; SUMO conjugating system; Transcription, coactivator/corepressor	O75925	8554	PIAS1	15q	human	S466	PHOSPHORYLATION	4700782	VIDLTIDsSSDEEEE		molecular association, regulation	transcription, inhibited	SUMO2(INDUCES); SUMO1(INDUCES)		6829202	2	5	0		
CEACAM1	Cell adhesion; Immunoglobulin superfamily; Membrane protein, integral; Motility/polarity/chemotaxis	P13688	634	CEACAM1	19q13.2	human	T457	PHOSPHORYLATION	3439801	CFLHFGKtGRASDQR	DUF2668; Form-deh_trans	activity, inhibited	apoptosis, altered			6277002	4	0	0	blocks formation of lumen	
MEN1 iso2	Transcription, coactivator/corepressor	O00255-2	4221	MEN1	11q13	human	S394	PHOSPHORYLATION	477697	EERPGEQsQGTQSQG	Menin	phosphorylation				18021024	1	2	6	important for dephosphorylation of S487	
Kv7.1	Channel, potassium; Membrane protein, integral; Membrane protein, multi-pass	P51787	3784	KCNQ1	11p15.5	human	T513	PHOSPHORYLATION	456164	LREHHRAtIKVIRRM	KCNQ_channel	activity, induced				6659	1	0	0		
TXA2-R iso2	GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR	P21731-2	6915	TBXA2R	19p13.3	human	S330	PHOSPHORYLATION	18790001	LSTRPRRsLTLWPSL		receptor desensitization, altered				8851; 5336	2	0	0		
HDAC7	EC 3.5.1.98; Hydrolase	Q8C2B3	56233	Hdac7		mouse	S344	PHOSPHORYLATION	455621	RPLNRTRsEPLPPSA		molecular association, regulation		14-3-3 epsilon(DISRUPTS)		4281702	5	5	18		
PELI1	Adaptor/scaffold; EC 6.3.2.-; EC 6.3.2.19; Ligase; UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase	Q96FA3	57162	PELI1	2p13.3	human	T288	PHOSPHORYLATION	7388016	QCPVGFNtLAFPSMK	Pellino; zf-RING_2	ubiquitination; enzymatic activity, induced				7228504	2	0	0		
Rb-like 2	Transcription, coactivator/corepressor	Q08999	5934	RBL2	16q12.2	human	S688	PHOSPHORYLATION	449729	RLFVENDsPSDGGTP		molecular association, regulation	cell cycle regulation	E2F4(DISRUPTS)		1200	3	2	0		
GLP1R	GPCR, family 2; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR	P32301	25051	Glp1r		rat	S451	PHOSPHORYLATION	451369	SSGATVGsSVYAATC		receptor desensitization, altered				3574	1	0	0		
53BP1	Transcription, coactivator/corepressor	Q12888	7158	TP53BP1	15q15-q21	human	S1778	PHOSPHORYLATION	458312	FNKQYTEsQLRAGAG			apoptosis, altered			14989305	2	0	1		
Gab2	Adaptor/scaffold	Q9UQC2	9846	GAB2	11q14.1	human	Y452	PHOSPHORYLATION	448384	STNSEDNyVPMNPGS		molecular association, regulation		PIK3R1(INDUCES)		6227	4	0	27		
FOXM1	DNA binding protein; Transcription factor	Q08050	2305	FOXM1	12p13	human	T611	PHOSPHORYLATION	451437	ETLPISStPSKSVLP		protein stabilization	transcription, induced			22495316	4	3	3		
HOXB7	DNA binding protein; Motility/polarity/chemotaxis; Transcription factor	P09629	3217	HOXB7	17q21.3	human	T204	PHOSPHORYLATION	465572	KTAGPGTtGQDRAEA			cell differentiation, altered			8028	1	0	0		
NFAT3	DNA binding protein; Transcription factor	Q14934	4776	NFATC4	14q11.2	human	S281	PHOSPHORYLATION	13419502	SGTPSSAsPALSRRG			transcription, altered			12482414	1	1	0		
PDHK1	EC 2.7.11.2; KINASE; Kinase, protein; Mitochondrial; Protein kinase, ATYPICAL; Protein kinase, atypical	Q8BFP9	228026	Pdk1		mouse	Y242	PHOSPHORYLATION	465268	RRLCDLYyVNSPELE			cell growth, induced			25220606	1	1	1	Y to F mutants show decreased proliferation under hypoxia and increased oxidative phosphorylation. 	
NPHP1	Cell adhesion	O15259	4867	NPHP1	2q13	human	S126	PHOSPHORYLATION	26395105	EESESEDsEDSGGEE		molecular association, regulation; intracellular localization		PACS-1(INDUCES)		25785405	1	0	0		
SRR	Amino Acid Metabolism - glycine, serine and threonine; EC 4.3.1.17; EC 4.3.1.18; EC 5.1.1.18; Isomerase	Q9QZX7	27364	Srr		mouse	T71	PHOSPHORYLATION	14701400	IRGLIPDtPEEKPKA	PALP	enzymatic activity, induced				14699301	1	4	0		
NFAT1	DNA binding protein; Transcription factor	Q60591	18019	Nfatc2		mouse	S238	PHOSPHORYLATION	449626	DSCLGRHsPVPRPAS			transcription, inhibited			1188	0	5	5		
PU.1	DNA binding protein; Transcription factor	P17433	20375	Spi1		mouse	S41	PHOSPHORYLATION	13421401	DYYSFVGsDGESHSD			RNA splicing, altered; transcription, altered			13354736	1	0	0		
FOXO3A	Autophagy; DNA binding protein; Transcription factor	Q9WVH4	56484	Foxo3		mouse	S320	PHOSPHORYLATION	453424	NSNASTVsGRLSPIL		intracellular localization				12482251	6	0	0	nuclear export in FOXO6/FOXO3A chimera	
G-gamma(12)	G protein; G protein, heterotrimeric; G protein, heterotrimeric gamma	Q28024	286850	GNG12		cow	S3	PHOSPHORYLATION	447877	_____MSsKTASTNN	G-gamma		cell adhesion, altered			2635	1	0	0		
MCL1	Apoptosis; Channel, misc.; Inhibitor protein; Membrane protein, integral; Mitochondrial	Q07820	4170	MCL1	1q21	human	S159	PHOSPHORYLATION	460683	NNTSTDGsLPSTPPP		protein degradation	apoptosis, altered			7727	3	3	0		
Smad2	DNA binding protein; Transcription factor	Q15796	4087	SMAD2	18q21.1	human	S255	PHOSPHORYLATION	448796	ELSPTTLsPVNHSLD		activity, induced; protein stabilization; molecular association, regulation; intracellular localization; protein conformation	cell motility, altered; transcription, induced	Smad4(INDUCES)		6277008; 3386; 1956	4	0	0	induce vascular invasion	
CFTR	Channel, chloride; EC 3.6.3.49; Hydrolase; Membrane protein, integral; Membrane protein, multi-pass; Transporter	P13569	1080	CFTR	7q31.2	human	S737	PHOSPHORYLATION	449981	EPLERRLsLVPDSEQ	CFTR_R	activity, induced; molecular association, regulation; enzymatic activity, inhibited; activity, inhibited; protein conformation		CFTR(INDUCES)		7324312; 4474; 5930037; 8370; 2537	11	2	1		
Bim	Apoptosis	O54918	12125	Bcl2l11		mouse	S73	PHOSPHORYLATION	3306339	PGPFATRsPLFIFVR		protein degradation	apoptosis, inhibited			2915501	2	7	3		
hnRNP K	RNA binding protein; RNA splicing; Spliceosome	P61978	3190	HNRNPK	9q21.32-q21.33	human	Y230	PHOSPHORYLATION	456001	QPYDPNFyDETYDYG	Phi-29_GP3		translation, altered			6566	1	1	2	based on Y72/225/230/234/236/380A mutant	
APP	Apoptosis; Cell surface; Membrane protein, integral; Receptor, misc.; Transcription factor	P12023	11820	App		mouse	Y757	PHOSPHORYLATION	448202	SKMQQNGyENPTYKF	APP_amyloid	molecular association, regulation		Shc1(INDUCES)		3494	9	8	836		
ITGB4	Cell adhesion; Membrane protein, integral; Motility/polarity/chemotaxis; Receptor, misc.	P16144	3691	ITGB4	17q25	human	S1356	PHOSPHORYLATION	451653	YSDDVLRsPSGSQRP		molecular association, regulation	cell motility, altered; cytoskeletal reorganization	plectin 1(DISRUPTS)		12087; 15562502	5	1	2		
NuaK1	EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, CAMK; Protein kinase, Ser/Thr (non-receptor)	O60285	9891	NUAK1	12q23.3	human	S600	PHOSPHORYLATION	448726	PARQRIRsCVSAENF		activity, induced	cell motility, altered			1889; 3360	4	0	0		
SRC-3	ACETYLTRANSFERASE; Acetyltransferase; EC 2.3.1.48; Motility/polarity/chemotaxis; Nuclear receptor co-regulator; Transcription, coactivator/corepressor	Q9Y6Q9	8202	NCOA3	20q12	human	S1042	PHOSPHORYLATION	4252806	DDLVGPPsNLEGQSD		protein stabilization; molecular association, regulation		PSMA3(DISRUPTS)		4248206	1	0	0	some subset of these 8 residues	
P70S6KB	EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor); Translation	Q9UBS0	6199	RPS6KB2	11q13.2	human	S410	PHOSPHORYLATION	455989	SFQPKLRsPRRLNSS		enzymatic activity, induced				6518	2	0	3		
IL10RA	Membrane protein, integral; Receptor, cytokine	Q13651	3587	IL10RA	11q23	human	Y496	PHOSPHORYLATION	449608	PPALAKGyLKQDPLE		molecular association, regulation		CSRP1(INDUCES)		2249	1	0	1		
PIK3R1	Enzyme, regulatory subunit; KINASE; Kinase, lipid; Motility/polarity/chemotaxis	P26450	18708	Pik3r1		mouse	S652	PHOSPHORYLATION	20831301	TFLVRESsKQGCYAC	SH2	molecular association, regulation	signaling pathway regulation			20830900	1	1	0	;  impairs PI3K pathway activation; inhibits binding to to phospho-Tyr peptides	
FHOD1	Actin binding protein	Q9Y613	29109	FHOD1	16q22	human	S1131	PHOSPHORYLATION	451843	AARERKRsRGNRKSL		activity, induced	cytoskeletal reorganization; cell growth, altered	FHOD1(DISRUPTS)		17431547; 1968357	3	0	4	autoinhibitory interaction between C- and N-terminal part of FHOD1 is attenuated in S1130D/S1136D/T1140D triple mutant	
CSF2RB	Membrane protein, integral; Receptor, cytokine	P32927	1439	CSF2RB	22q13.1	human	Y711	PHOSPHORYLATION	450123	DPGVASGyVSSADLV		activity, induced; molecular association, regulation; phosphorylation	apoptosis, altered; cell motility, altered; transcription, altered; cell growth, altered	Shc1(INDUCES); SHP-2(INDUCES); Grb2(INDUCES)		3329; 2722; 8533	3	0	0		
PGC-1 alpha	Nuclear receptor co-regulator; Transcription, coactivator/corepressor	O70343	19017	Ppargc1a		mouse	S538	PHOSPHORYLATION	486320	SLFDVSPsCSSFNSP			transcription, altered			12059	1	1	0		
RSK4	EC 2.7.1.37; EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor)	Q9UK32	27330	RPS6KA6	Xq21	human	T581	PHOSPHORYLATION	4045800	GENGLLLtPCYTANF	Pkinase	phosphorylation; enzymatic activity, induced				7130	1	0	0	phosphorylation S389	
PML iso4	Transcription factor; Tumor suppressor; Ubiquitin conjugating system	P29590-4	5371	PML	15q22	human	T28	PHOSPHORYLATION	451468	PTMPPPEtPSEGRQP		protein stabilization	apoptosis, altered			3657	1	0	0	Phosphorylation of PML is associated with enhanced sumoylation and apoptosis induced by As2O3. 	
CACNA1H	Cell development/differentiation; Channel, calcium; Membrane protein, integral; Membrane protein, multi-pass	O95180	8912	CACNA1H	16p13.3	human	S1107	PHOSPHORYLATION	6729300	LPDSRRGsSSSGDPP		activity, inhibited				6331308	1	0	0		
CFTR	Channel, chloride; EC 3.6.3.49; Hydrolase; Membrane protein, integral; Membrane protein, multi-pass; Transporter	P13569	1080	CFTR	7q31.2	human	S712	PHOSPHORYLATION	455297	INSIRKFsIVQKTPL	CFTR_R	molecular association, regulation; enzymatic activity, inhibited		CFTR(INDUCES)		4474	4	2	0		
PKN2	EC 2.7.11.13; KINASE; Kinase, protein; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor)	Q16513	5586	PKN2	1p22.2	human	T958	PHOSPHORYLATION	2509079	TSEAPILtPPREPRI	Pkinase_C	molecular association, regulation; enzymatic activity, inhibited; protein conformation; enzymatic activity, induced		PDK1(DISRUPTS)		10353916; 11751	2	24	15		
FOXO3A	Autophagy; DNA binding protein; Transcription factor	O43524	2309	FOXO3	6q21	human	S626	PHOSPHORYLATION	20799905	SLECDMEsIIRSELM		molecular association, regulation	transcription, induced	CBP(INDUCES)		25227622	3	0	0		
RAF1	EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, Ser/Thr (non-receptor); Protein kinase, TKL	Q99N57	110157	Raf1		mouse	S233	PHOSPHORYLATION	448651	ASSQHRYsTPHAFTF		enzymatic activity, inhibited	cell growth, altered			1846	2	2	2		
mGluR3	GPCR, family 3; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR	P31422	24416	Grm3		rat	S845	PHOSPHORYLATION	450252	RLHLNRFsVSGTATT		molecular association, regulation		PPPM1A(DISRUPTS)		2959	1	0	0		
PGRMC1	Membrane protein, integral; Receptor, misc.	O00264	10857	PGRMC1	Xq22-q24	human	S181	PHOSPHORYLATION	452525	GEEPTVYsDEEEPKD			cell cycle regulation; apoptosis, altered; apoptosis, induced			5007909; 7543513	2	61	145		
DMBT1	Membrane protein, integral; Secreted; Secreted, signal peptide	Q60997	12945	Dmbt1		mouse	S2082	PHOSPHORYLATION	13201903	IDRGQPPsTKL____		molecular association, regulation	exocytosis, altered; cytoskeletal reorganization	NHERF(INDUCES); ACTB(INDUCES)		12668816	1	0	0	Phosphomimetic peptides associate with the cytoskeleton, though not binding directly to actin.	
MRLC1	Contractile protein; Motility/polarity/chemotaxis	Q64122	296313	Myl9		rat	S20	PHOSPHORYLATION	1863500	KRPQSATsNVFAMFD			cytoskeletal reorganization			22518523	30	27	281	 T19, S20 di-phosphorylation is recquired for dendritic spine maturation;  mono phosphorylation inhibits spine maturation.	
LRRK2	EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, Ser/Thr (non-receptor); Protein kinase, TKL	Q5S006	66725	Lrrk2		mouse	S935	PHOSPHORYLATION	4725898	NAQRHSNsLGPVFDH		molecular association, regulation		14-3-3 beta(INDUCES); 14-3-3 theta(INDUCES); 14-3-3 zeta(INDUCES); 14-3-3 epsilon(INDUCES); 14-3-3 gamma(INDUCES); 14-3-3 eta(INDUCES)		18668215; 15022721; 15022728	12	9	2	reduced in LRRK2 mutants R1441G or Y1699C	
tau iso3	Cytoskeletal protein	P10636-3	4137	MAPT	17q21.1	human	T137	PHOSPHORYLATION	449079	KKVAVVRtPPKSPSS		molecular association, regulation	cytoskeletal reorganization			5955602	74	20	10	regulates association with membrane	
Syk	EC 2.7.10.2; KINASE; Kinase, protein; Protein kinase, TK; Protein kinase, tyrosine (non-receptor)	P43405	6850	SYK	9q22	human	Y323	PHOSPHORYLATION	447658	STVSFNPyEPELAPW		molecular association, regulation; enzymatic activity, induced		Cbl(INDUCES); Fyn(INDUCES)		7324133	14	18	1010		
RKHD3	RNA binding protein; Ubiquitin conjugating system	Q6ZN04	84206	MEX3B	15q25.2	human	S462	PHOSPHORYLATION	4668104	HLARRVRsDPGGGGL		protein stabilization; molecular association, regulation; intracellular localization		14-3-3 eta(INDUCES)		4641415	1	0	0		
CKAP2	Cell cycle regulation	Q8WWK9	26586	CKAP2	13q14	human	S628	PHOSPHORYLATION	7603500	FLTPVRRsRRLQEKT		intracellular localization				14551421	2	0	1		
LIG1	DNA repair; EC 6.5.1.1; Ligase	P18858	3978	LIG1	19q13.2-q13.3	human	S51	PHOSPHORYLATION	468123	GVVSESDsPVKRPGR		molecular association, regulation; intracellular localization	cell cycle regulation; cytoskeletal reorganization; DNA repair, inhibited; cell growth, altered	RFC1(INDUCES); Rad17(DISRUPTS); RFC1(DISRUPTS)		26341727; 7072901; 8424	3	30	7	S51D mutant induces cellular senescence ; regulates DNA replication and repair	
calponin 1	Actin binding protein; Contractile protein; Motility/polarity/chemotaxis; Myosin binding protein	Q08092	396911	CNN1		pig	S175	PHOSPHORYLATION	450890	MGTNKFAsQQGMTAY	Calponin	activity, induced				3172	2	1	0	Phosphorylation of calponin at S175 may play a role in vasoconstriction.	
K8	Cytoskeletal protein	P11679	16691	Krt8		mouse	S438	PHOSPHORYLATION	448540	SSYGGLTsPGFSYGM		molecular association, regulation; intracellular localization	cytoskeletal reorganization			1030; 7768	20	2	20		
GYS2	Carbohydrate Metabolism - starch and sucrose; Cytoskeletal protein; EC 2.4.1.11; Transferase	P17625	25623	Gys2		rat	S641	PHOSPHORYLATION	7390700	FKYPRPSsVPPSPSG	Glycogen_syn	phosphorylation				7124716	1	0	0	S641A mutant caused decrease in S645 phosphorylation	
TRPV6	Channel, calcium; Membrane protein, integral; Membrane protein, multi-pass	Q9H1D0	55503	TRPV6	7q34	human	S144	PHOSPHORYLATION	12173901	LARRASVsARATGTA	Ank_2	activity, inhibited				12021338	1	0	0	involved in regulation of calcium influx by ATP 	
diaphanous 1	Actin binding protein; Adaptor/scaffold; Motility/polarity/chemotaxis	O60610	1729	DIAPH1	5q31	human	T768	PHOSPHORYLATION	3946102	PVLPFGLtPKKLYKP	FH2	protein degradation; molecular association, regulation		KIF1A(INDUCES); ACTB(INDUCES)		27519644	2	1	0	induces sumoylation;  modulates mitochondrial movement	
DDX5	EC 3.6.1.-; EC 3.6.4.13; Helicase; Nuclear receptor co-regulator; RNA binding protein; RNA splicing; Spliceosome	P17844	1655	DDX5	17q21	human	T446	PHOSPHORYLATION	15409321	GTAYTFFtPNNIKQV			apoptosis, induced			27132487	1	0	4		
Akt1	EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor)	P47196	24185	Akt1		rat	S473	O-GlcNAc	4261200	RPHFPQFsYSASGTA	Pkinase_C	phosphorylation				4261000	2	0	0	O-GlcNAc modification at Akt S473 competes with phosphorylation at Akt S473	
P130Cas	Adaptor/scaffold; Motility/polarity/chemotaxis	P56945	9564	BCAR1	16q23.1	human	S139	PHOSPHORYLATION	483627	GPSPQFQsPPAKQTS		intracellular localization	cell motility, altered			7964804	1	9	8		
CITED1	Nuclear receptor co-regulator	P97769	12705	Cited1		mouse	S73	PHOSPHORYLATION	27937112	GSTSPIGsPTATPSS	CITED	intracellular localization	cell differentiation, induced			27780046	1	0	0	S63/64/65/67/69/73/79/80/84A mutation in CITED1 inhibits its translocation into the nucleus and osteoblasts differentiation	
STAT1	DNA binding protein; Transcription factor	P42225	20846	Stat1		mouse	S708	PHOSPHORYLATION	7723201	YIKTELIsVSEVHPS			transcription, altered			7663500	1	1	0		
APC	Motility/polarity/chemotaxis; Tumor suppressor	P25054	324	APC	5q21-q22	human	S1279	PHOSPHORYLATION	450136	SRCSSLSsLSSAEDE	APC_crr	molecular association, regulation	transcription, altered	CTNNB1(INDUCES)		2751	1	0	0		
CrkL	Adaptor/scaffold; Motility/polarity/chemotaxis	P46109	1399	CRKL	22q11.21	human	Y207	PHOSPHORYLATION	447954	IPEPAHAyAQPQTTT		molecular association, regulation; activity, inhibited		PXN(DISRUPTS)		4055	9	15	1183	Y207 is a negative regulatory phosphorylation site in CrkL	
PPAR-gamma	DNA binding protein; Nuclear receptor	P37238	19016	Pparg		mouse	S273	PHOSPHORYLATION	15175800	TGKTTDKsPFVIYDM			transcription, altered			15022727	4	1	0		
CENTB1	GTPase activating protein, ARF; Motility/polarity/chemotaxis	Q15027	9744	ACAP1	17p13.1	human	S554	PHOSPHORYLATION	458238	SIRPRPGsLRSKPEP		molecular association, regulation	cell motility, altered	ITGB1(INDUCES)		7329	1	1	1		
CCKBR	GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR	P32239	887	CCKBR	11p15.4	human	S442	PHOSPHORYLATION	17825903	RLSYTTIsTLGPG__		molecular association, regulation		ARRB1(INDUCES)		17675032	1	0	0		
E2F1	DNA binding protein; Transcription factor	Q01094	1869	E2F1	20q11.2	human	S375	PHOSPHORYLATION	3193946	PVDEDRLsPLVAADS			transcription, inhibited			26341724	2	4	0		
BRCA1	EC 6.3.2.-; Nuclear receptor co-regulator; Transcription, coactivator/corepressor; Tumor suppressor; UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase	P48754	12189	Brca1		mouse	S1152	PHOSPHORYLATION	450007	LRRESSRsPSPVTHA			apoptosis, altered			12028113	4	5	6	 confers resistance to gamma-radiation by preventing radiation-induced apoptosis; required for proper skin structure and hair regeneration;  required for tumor prevention	
STXBP3	Vesicle protein	Q60770	20912	Stxbp3		mouse	Y521	PHOSPHORYLATION	459181	RQKPRTNyLELDRKN	Sec1	molecular association, regulation		STX4(DISRUPTS)		970030; 28722429	4	6	56	 PDGF induced Glut4 translocation; 2-deoxy-glucose uptake in adipocytes	
SMPD3	EC 3.1.4.12; Lipid Metabolism - sphingolipid; Membrane protein, integral; Phospholipase	Q9JJY3	58994	Smpd3		mouse	S208	PHOSPHORYLATION	17547980	GSIKRTAsVEYKGDG		protein stabilization				22463914	1	4	0		
Ikaros	C2H2-type zinc finger protein; DNA binding protein; Transcription factor	Q03267	22778	Ikzf1		mouse	T140	PHOSPHORYLATION	451354	MVHKRSHtERPFQCN	zf-H2C2_2		transcription, altered			3560	1	0	0		
TRPC3 iso3	Channel, cation; Membrane protein, integral; Membrane protein, multi-pass	Q13507-3	7222	TRPC3	4q27	human	T11	PHOSPHORYLATION	458335	SPSLRRMtVMREKGR		activity, inhibited				7387; 8870	2	0	0	inhibits store-operated calcium influx	
GABRG2	Channel, chloride; Channel, ligand-gated; Membrane protein, integral; Membrane protein, multi-pass	P22723	14406	Gabrg2		mouse	Y413	PHOSPHORYLATION	455818	ERDEEYGyECLDGKD	Neur_chan_memb	activity, induced; receptor internalization, altered				11999215	7	0	0	spatial object recognition in mice	
p63	DNA binding protein; Transcription factor	Q9H3D4	8626	TP63	3q28	human	Y290	PHOSPHORYLATION	10359106	RQSVLVPyEPPQVGT	P53	protein stabilization				10353933	1	0	0		
raptor	Adaptor/scaffold	Q8N122	57521	RPTOR	17q25.3	human	S696	PHOSPHORYLATION	11315003	EKNYALPsPATTEGG		phosphorylation				18415121	7	4	1	mutation of S696A interferes with the insulin-stimulated phosphorylation of p70S6K	
HuR	RNA binding protein	Q15717	1994	ELAVL1	19p13.2	human	T118	PHOSPHORYLATION	474554	SGLPRTMtQKDVEDM	RRM_1	molecular association, regulation; intracellular localization	RNA stability, altered	p21Cip1(INDUCES)	RNA(INDUCES)	9316; 9980412	4	0	3	Phosphorylation by Chk2 regulates binding of ELAV1 to mRNAs affecting mRNA stabliity.	
PXN	Adaptor/scaffold; Cell adhesion; Cytoskeletal protein; Motility/polarity/chemotaxis	Q66H76	360820	Pxn		rat	Y31	PHOSPHORYLATION	448785	FLSEEPPySYPTGNH		activity, induced; molecular association, regulation	cell motility, altered	DOCK1(INDUCES); Crk(INDUCES)		4744	35	6	64	activation of Rac1	
Met	EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Protein kinase, TK; Protein kinase, tyrosine (receptor)	P16056	17295	Met		mouse	Y1354	PHOSPHORYLATION	448473	YVHVNATyVNVKCVA		molecular association, regulation	cell motility, altered; cytoskeletal reorganization	Shc1(INDUCES); PIK3C2A(INDUCES); Gab1(INDUCES); Grb2(INDUCES)		2849; 2850	20	4	89		
PRPF19	EC 6.3.2.-; EC 6.3.2.19; Ligase; RNA splicing; Spliceosome; UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase	Q9UMS4	27339	PRPF19	11q12.2	human	T193	PHOSPHORYLATION	17331800	ERKKRGKtVPEELVK		molecular association, regulation; intracellular localization		14-3-3 beta(INDUCES); CDC5L(INDUCES)		15785002	1	0	0	involved in neuronal differentiation	
SLC9A5	Membrane protein, integral; Membrane protein, multi-pass; Transporter	Q14940	6553	SLC9A5	16q22.1	human	S702	PHOSPHORYLATION	20832300	AVILTVEsEEEEEES		molecular association, regulation; activity, inhibited	endocytosis, induced	ARRB1(INDUCES)		20655009	1	0	0	In intact cells ARRB1 ST/AA mutant retained ability to form a complex. 	
Kv2.1	Channel, cation; Channel, ligand-gated; Channel, potassium; Membrane protein, integral; Membrane protein, multi-pass	P15387	25736	Kcnb1		rat	S567	PHOSPHORYLATION	473554	LEMSSMPsPVAPLPA	Kv2channel	activity, inhibited				9216	4	6	0		
ADAM22	Cell adhesion; Membrane protein, integral; Motility/polarity/chemotaxis	Q9P0K1	53616	ADAM22	7q21	human	S857	PHOSPHORYLATION	469109	RFRPRSNsTETLSPA		protein stabilization; molecular association, regulation; intracellular localization		14-3-3 beta(INDUCES); 14-3-3 theta(INDUCES); 14-3-3 zeta(INDUCES); 14-3-3 epsilon(INDUCES); 14-3-3 gamma(INDUCES); 14-3-3 eta(INDUCES)		8234	1	9	62		
NFAT1	DNA binding protein; Transcription factor	Q60591	18019	Nfatc2		mouse	S174	PHOSPHORYLATION	447841	LCLSPASsGSSASFI			transcription, inhibited			1188	0	1	0		
AML1	DNA binding protein; Transcription factor	Q01196	861	RUNX1	21q22.3	human	S266	PHOSPHORYLATION	454400	QYLGSIAsPSVHPAT		activity, induced; molecular association, regulation; phosphorylation	transcription, altered; cell growth, altered	CBFB(INDUCES)		8075512; 4042514	7	1	25		
TBCB	Chaperone; Cytoskeletal protein; Motility/polarity/chemotaxis	Q99426	1155	TBCB	19q13.11-q13.12	human	S65	PHOSPHORYLATION	455784	GVDDKFYsKLDQEDA			cytoskeletal reorganization			5800; 1172870	2	0	0		
CSF2RB	Membrane protein, integral; Receptor, cytokine	P32927	1439	CSF2RB	22q13.1	human	Y628	PHOSPHORYLATION	450121	PPPGSLEyLCLPAGG		activity, induced; molecular association, regulation; phosphorylation	apoptosis, altered; cell motility, altered; transcription, altered; cell growth, altered	Shc1(INDUCES); SHP-2(INDUCES); Grb2(INDUCES)		3329; 2722; 8533; 3210; 8395	6	0	0		
TNNI3	Actin binding protein; Motility/polarity/chemotaxis; Motor protein	P19429	7137	TNNI3	19q13.4	human	S23	PHOSPHORYLATION	448423	PAPIRRRsSNYRAYA	Troponin-I_N	molecular association, regulation	cytoskeletal reorganization	TNNC1(DISRUPTS)		7362300; 2391	37	4	11	muscle contraction	
CTNND1	Actin binding protein; Adaptor/scaffold; Cell adhesion; G protein regulator, misc.; Motility/polarity/chemotaxis	P30999	12388	Ctnnd1		mouse	Y228	PHOSPHORYLATION	449648	YPGGSDNyGSLSRVT		molecular association, regulation		RhoA(INDUCES); CDH1(INDUCES)		9157	4	26	1067		
Nlp	Cell cycle regulation; Microtubule binding protein	Q9Y2I6	22981	NINL	20p11.22-p11.1	human	S448	PHOSPHORYLATION	15668107	QGYRERLsLLRSEVE		intracellular localization	cell cycle regulation			15562527	1	1	0		
SPT5	Transcription, coactivator/corepressor	O00267	6829	SUPT5H	19q13	human	T775	PHOSPHORYLATION	458815	TPMYGSQtPMYGSGS	CTD		transcription, altered			7460	2	1	37	required for c-fos induction and activation in vivo	
EPB41 iso4	Cytoskeletal protein	P11171-4	2035	EPB41	1p33-p32	human	Y13	PHOSPHORYLATION	463285	SLLDDTVyECVVEKH	FERM_N		cytoskeletal reorganization			13359104	1	4	47		
ODF2 iso3	Cancer Testis Antigen (CTA); Cytoskeletal protein	Q5BJF6-3	4957	ODF2	9q34.11	human	S796	PHOSPHORYLATION	449230	YSTFLTSsPIRSRSP		molecular association, regulation	cytoskeletal reorganization	PLK1(INDUCES)		7543530	1	5	0		
Lmr1	EC 2.7.11.1; KINASE; Kinase, protein; Membrane protein, integral; Protein kinase, TK; Protein kinase, tyrosine (receptor)	Q80YE4	11302	Aatk		mouse	S606	PHOSPHORYLATION	456514	HSHRRQGsPCPSRSP			apoptosis, induced			6694	1	0	0		
caldesmon	Actin binding protein	P12957	373965	CALD1		chicken	S615	PHOSPHORYLATION	2873302	RAEFLNKsAQKSGMK	Caldesmon	molecular association, regulation		ACTB(NOT_REPORTED)		2852623	1	4	0		
PTPRH	EC 3.1.3.48; Membrane protein, integral; Motility/polarity/chemotaxis	NP_997153	545902	Ptprh		mouse	Y953	PHOSPHORYLATION	10804386	ENVASLVyENASAIM		molecular association, regulation	cytoskeletal reorganization	Fyn(INDUCES); Grb2(INDUCES)		14081207	1	0	1		
NCAM-L1	Cell adhesion; Membrane protein, integral	Q05695	50687	L1cam		rat	Y1178	PHOSPHORYLATION	456529	KDETFGEyRSLESDN	Bravo_FIGEY	molecular association, regulation; intracellular localization		ezrin(DISRUPTS); SNAP-91(DISRUPTS); AP2M1(DISRUPTS)		4651304; 8606	10	1	10		
PKR	EC 2.7.10.2; EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor); Translation	P19525	5610	EIF2AK2	2p22-p21	human	Y293	PHOSPHORYLATION	458273	HRIDGKTyVIKRVKY	Pkinase	enzymatic activity, induced	translation, altered; cell growth, altered			7342	1	0	0		
Shc1	Adaptor/scaffold; Apoptosis; Mitochondrial; Motility/polarity/chemotaxis	P29353	6464	SHC1	1q21	human	Y350	PHOSPHORYLATION	448510	EPPDHQYyNDFPGKE		molecular association, regulation	apoptosis, altered; apoptosis, inhibited	Grb2(INDUCES)		1274; 7309803; 6149	24	14	919		
SCN2A	Channel, sodium; Membrane protein, integral; Membrane protein, multi-pass	P04775	24766	Scn2a		rat	S554	PHOSPHORYLATION	452015	TYEKRFSsPHQSLLS	DUF3451	activity, inhibited				8665	2	7	2		
PXN iso2	Adaptor/scaffold; Cell adhesion; Cytoskeletal protein; Motility/polarity/chemotaxis	P49023-2	5829	PXN	12q24.31	human	S272	PHOSPHORYLATION	465466	ELDELMAsLSDFKFM		molecular association, regulation; intracellular localization	cell motility, altered; cytoskeletal reorganization; cell adhesion, altered	GIT1(INDUCES); GIT1(DISRUPTS); ARHGEF6(INDUCES)		7990; 14058630; 4042531; 3309511; 6804214	7	6	0	critical for OxPAPC-induced pulmonary endothelial barrier protection; mediates focal-adhesion disassembly	
CCDC50 iso2	Inhibitor protein	Q8IVM0	152137	CCDC50	3q28	human	Y279	PHOSPHORYLATION	462101	TDGEDADyTHFTNQQ		phosphorylation	apoptosis, inhibited; cell growth, altered			6376200	1	8	79	 ;  inhibits NF-kB activity; inhibits phosphorylation of IKKbeta through TNFalpha	
DAB2IP	GTPase activating protein, Ras	Q5VWQ8	153090	DAB2IP	9q33.1-q33.3	human	S728	PHOSPHORYLATION	478274	PSPARSSsYSEANEP	DUF3498	molecular association, regulation	apoptosis, induced; transcription, altered	14-3-3 beta(INDUCES); RIPK1(INDUCES); ASK1(INDUCES); TRAF2(INDUCES)		9600	1	0	1		
FAK	EC 2.7.1.112; EC 2.7.10.2; KINASE; Kinase, protein; Protein kinase, TK; Protein kinase, tyrosine (non-receptor)	Q05397	5747	PTK2	8q24.3	human	Y577	PHOSPHORYLATION	447890	YMEDSTYyKASKGKL	Pkinase_Tyr	enzymatic activity, induced; phosphorylation	cell differentiation, altered; cell motility, induced; cytoskeletal reorganization; cell adhesion, altered; transcription, altered			27856300; 4894707; 2621609; 2865401	64	29	1766		
GluR5 iso2	Channel, ligand-gated; Membrane protein, integral; Membrane protein, multi-pass	P39086-2	2897	GRIK1	21q22.11	human	S885	PHOSPHORYLATION	457627	KSRTKGKsSFTSILT		receptor desensitization, altered; receptor internalization, altered				762736	2	0	0	induced by phorbol ester	
PKD1	Autophagy; EC 2.7.11.13; KINASE; Kinase, protein; Motility/polarity/chemotaxis; Protein kinase, CAMK; Protein kinase, Ser/Thr (non-receptor)	Q62101	18760	Prkd1		mouse	S407	PHOSPHORYLATION	3196826	RTISPSTsNNIPLMR		enzymatic activity, inhibited				7303911	1	9	2	in vitro	
B-Myb	DNA binding protein; Motility/polarity/chemotaxis; Transcription factor	P48972	17865	Mybl2		mouse	S581	PHOSPHORYLATION	450115	RKPGLRRsPIKKVRK	Cmyb_C	activity, induced	transcription, induced			2713; 3936	4	0	0		
TORC2	Transcription, coactivator/corepressor	Q8BH09	74343	Crtc2		mouse	S70	O-GlcNAc	10902812	RSSHYGGsLPNVNQI	TORC_N	activity, induced; molecular association, regulation; intracellular localization; phosphorylation		14-3-3 beta(DISRUPTS)		6337804	1	1	0	inhibits phosphorylation of its own site	
NCAM-L1	Cell adhesion; Membrane protein, integral	P32004	3897	L1CAM	Xq28	human	S1204	PHOSPHORYLATION	472276	GDIKPLGsDDSLADY	Bravo_FIGEY		cytoskeletal reorganization			9177	2	0	0		
Tel	DNA binding protein; Motility/polarity/chemotaxis; Transcription factor	P41212	2120	ETV6	12p13	human	Y314	PHOSPHORYLATION	454814	SHREDLAyMNHIMVS		activity, induced; molecular association, regulation		Grb2(INDUCES)		5348	1	0	1	RAS activation	
PKD1	Autophagy; EC 2.7.11.13; KINASE; Kinase, protein; Motility/polarity/chemotaxis; Protein kinase, CAMK; Protein kinase, Ser/Thr (non-receptor)	Q9WTQ1	85421	Prkd1		rat	S748	PHOSPHORYLATION	448590	GEKSFRRsVVGTPAY	Pkinase	enzymatic activity, induced				2439	47	27	23		
ER-beta	DNA binding protein; Nuclear receptor	Q92731	2100	ESR2	14q23.2	human	S87	PHOSPHORYLATION	447915	WPTPGHLsPLVVHRQ	ERbeta_N; Oest_recep	activity, induced				7179	3	0	0		
FOXA2	DNA binding protein; Transcription factor	P32182		Foxa2		rat	S283	PHOSPHORYLATION	8046508	TAPGTQAsQVQLGEA			transcription, altered			7889924	1	0	0		
PRC1	Cell cycle regulation; Cytoskeletal protein; Microtubule binding protein; Motility/polarity/chemotaxis	O43663	9055	PRC1	15q26.1	human	S615	PHOSPHORYLATION	4274308	ATSGILNsTNIQS__	MAP65_ASE1	molecular association, regulation		PLK1(INDUCES)		25785411	2	0	0	phosphorylation and docking site of PLK1	
hnRNP K	RNA binding protein; RNA splicing; Spliceosome	P61978	3190	HNRNPK	9q21.32-q21.33	human	Y236	PHOSPHORYLATION	456003	FYDETYDyGGFTMMF	Phi-29_GP3		translation, altered			6566	1	1	0	based on Y72/225/230/234/236/380A mutant	
Srcasm	Adaptor/scaffold	Q923U0	71943	Tom1l1		mouse	Y441	PHOSPHORYLATION	451209	DLQPPNYyEVMEFDP		molecular association, regulation		PIK3R1(INDUCES)		3437	1	0	5		
TRPV4	Channel, cation; Membrane protein, integral; Membrane protein, multi-pass	Q9HBA0	59341	TRPV4	12q24.1	human	S189	PHOSPHORYLATION	10272404	DEEFREPsTGKTCLP		activity, induced				9980421	1	0	0		
myocardin	Cell development/differentiation; Transcription factor	Q8VIM5	214384	Myocd		mouse	S462	PHOSPHORYLATION	3627507	TSSSPPIsPASSDLS			transcription, inhibited			6856	1	0	0		
FGFR3	EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Protein kinase, TK; Protein kinase, tyrosine (receptor)	P22607	2261	FGFR3	4p16.3	human	Y770	PHOSPHORYLATION	2036700	LSAPFEQySPGGQDT			cell growth, altered			2465	1	0	0	Y770F  mutation increases the transforming activity of FGFR3	
CCR2	GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR	P41597	729230	CCR2	3p21.31	human	Y139	PHOSPHORYLATION	448635	ILLTIDRyLAIVHAV	7tm_1	molecular association, regulation		JAK2(INDUCES); G-alpha2(i)(INDUCES); STAT3(INDUCES)		1832	1	0	0		
vimentin	Cytoskeletal protein; Motility/polarity/chemotaxis	P08670	7431	VIM	10p13	human	S55	PHOSPHORYLATION	476052	TSRSLYAsSPGGVYA	Filament_head; DUF2464	molecular association, regulation	cytoskeletal reorganization	IDE(INDUCES)		12068404	4	8	28	intermediate filament disassembly	
Cx43	Channel, misc.; Membrane protein, integral; Membrane protein, multi-pass; Motility/polarity/chemotaxis	P23242	14609	Gja1		mouse	S325	PHOSPHORYLATION	449992	NRMGQAGsTISNSHA		intracellular localization				8241	7	9	0	ischemia induces connexin43 dephosphorylation and its relocalization in the cell and as a result downregulates intracellular communication	
TWIST1	Cell development/differentiation; DNA binding protein; Inhibitor protein; Transcription regulation	Q15672	7291	TWIST1	7p21.2	human	S20	PHOSPHORYLATION	18899300	ADDSLSNsEEEPDRQ		protein stabilization	carcinogenesis, altered; cell motility, altered			18837506	1	0	0		
DYN1	EC 3.6.5.5; Hydrolase; Microtubule binding protein; Motility/polarity/chemotaxis; Motor protein; Vesicle protein	P21575	140694	Dnm1		rat	S774	PHOSPHORYLATION	450205	SVPAGRRsPTSSPTP		molecular association, regulation	endocytosis, altered	endophilin 1(INDUCES); PACSIN1(INDUCES); PACSIN1(DISRUPTS)		11471; 14780527; 7850	7	16	19	regulates synaptic vesicle endocytosis; required for activity-dependent bulk endocytosis (ADBE), but not clathrin-mediated endocytosis (CME) ; interaction essential for  synaptic vesicle endocytosis	
RAF1	EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, Ser/Thr (non-receptor); Protein kinase, TKL	P04049	5894	RAF1	3p25	human	S471	PHOSPHORYLATION	456813	IIHRDMKsNNIFLHE	Pkinase_Tyr	molecular association, regulation; enzymatic activity, induced		MEK1(INDUCES)		6115934; 6878	2	2	0		
mGluR5 iso2	GPCR, family 3; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR	P31424-2	24418	Grm5		rat	S901	PHOSPHORYLATION	4213805	QHLWQRLsVHINKKE		protein degradation; molecular association, regulation; intracellular localization		calmodulin(DISRUPTS)		27257030; 4042518	2	0	1		
LAB	Adaptor/scaffold; Membrane protein, integral	Q9GZY6	7462	LAT2	7q11.23	human	Y193	PHOSPHORYLATION	450645	EDEESEDyQNSASIH		molecular association, regulation	cell differentiation, altered	PLCG1(INDUCES); Grb2(INDUCES)		3080; 1172831	3	5	151		
hnRNP K	RNA binding protein; RNA splicing; Spliceosome	P61978	3190	HNRNPK	9q21.32-q21.33	human	S284	PHOSPHORYLATION	448185	RRDYDDMsPRRGPPP		intracellular localization	translation, altered; transcription, inhibited	PPP1CA(INDUCES)		7642; 1119	5	56	161		
PEA-15	Apoptosis; Motility/polarity/chemotaxis	Q9Z297	100736554	Pea15		hamster	S116	PHOSPHORYLATION	450281	KDIIRQPsEEEIIKL		molecular association, regulation		FADD(INDUCES)		5792	8	46	1052		
APC	Motility/polarity/chemotaxis; Tumor suppressor	P25054	324	APC	5q21-q22	human	S2789	PHOSPHORYLATION	2897402	TPFNYNPsPRKSSAD	EB1_binding	molecular association, regulation		EB1(DISRUPTS)		9985931; 8432	0	3	1		
PDHK1	EC 2.7.11.2; KINASE; Kinase, protein; Mitochondrial; Protein kinase, ATYPICAL; Protein kinase, atypical	Q8BFP9	228026	Pdk1		mouse	Y136	PHOSPHORYLATION	11057941	AEDAKTIyEFTDTVI	BCDHK_Adom3; Bacillus_HBL	molecular association, regulation	cell growth, induced	DLAT(INDUCES)		25220606	1	0	3	Y to F mutants show decreased proliferation under hypoxia and increased oxidative phosphorylation. 	
FAK	EC 2.7.1.112; EC 2.7.10.2; KINASE; Kinase, protein; Protein kinase, TK; Protein kinase, tyrosine (non-receptor)	Q05397	5747	PTK2	8q24.3	human	S843	PHOSPHORYLATION	447963	DVRLSRGsIDREDGS			cytoskeletal reorganization			9389	7	8	7	represses phosphorylation of Y397 in integrin-stimulated cells	
PDE11A	EC 3.1.4.17; EC 3.1.4.35; Mitochondrial; Nucleotide Metabolism - purine; Phosphodiesterase	Q9HCR9	50940	PDE11A	2q31.2	human	S117	PHOSPHORYLATION	2243101	GNLQRRAsQKELRKS		enzymatic activity, induced				2195466	1	0	0		
Dok1	Adaptor/scaffold; Motility/polarity/chemotaxis	Q99704	1796	DOK1	2p13	human	Y362	PHOSPHORYLATION	448367	DPKEDPIyDEPEGLA		molecular association, regulation; phosphorylation		RASA1(INDUCES); Nck1(INDUCES)		1354	7	22	510		
ezrin	Cytoskeletal protein; Motility/polarity/chemotaxis	P26040	22350	Ezr		mouse	T567	PHOSPHORYLATION	448104	QGRDKYKtLRQIRQG	ERM	activity, induced; molecular association, regulation; intracellular localization; phosphorylation	cell growth, inhibited; apoptosis, inhibited; cell motility, altered; cell motility, inhibited; cytoskeletal reorganization; cell adhesion, inhibited	ezrin(INDUCES); MCF2(INDUCES)		12066002; 2165; 2385; 25185209; 7257; 4894706; 4772	37	3	15	T567A mutants suppressed tumor metastasis, increased apoptosis, reduced lactate metabolism and oxygen consumption.  ; iincreased filopodia with phosphorylated ERM proteins	
Src	EC 2.7.10.2; KINASE; Kinase, protein; Protein kinase, TK; Protein kinase, tyrosine (non-receptor)	P00523	396442	SRC		chicken	S48	PHOSPHORYLATION	2420700	PDTHRTPsRSFGTVA		phosphorylation	cell growth, altered			1277	1	2	0	Mutation of S16 increases phosphorylation at S12	
TIEG2	C2H2-type zinc finger protein; DNA binding protein; Transcription factor	O14901	8462	KLF11	2p25	human	T73	PHOSPHORYLATION	456008	LLRIRPLtPVSDSGD		molecular association, regulation		SIN3A(DISRUPTS)		6578	1	0	1		
IRF8	DNA binding protein; Transcription factor	P23611	15900	Irf8		mouse	Y211	PHOSPHORYLATION	486243	QMVISFYyGGKLVGQ	IRF-3	molecular association, regulation	transcription, induced	PU.1(INDUCES); STAT1(INDUCES)		12079	1	0	0	; as a part of IRF8-PU.1-STAT1 complex binding to LILRE (LPS and IL1 responsive element) regulates IL1B gene expression;  Y211F mutant is  a dominant-negative inhibitor of LPS-induced IL1B reporter gene	
NUP98 iso2	Motility/polarity/chemotaxis; Nucleoporin	P52948-2	4928	NUP98	11p15.5	human	S499	PHOSPHORYLATION	18330801	TYSPFGDsPLFRNPM		intracellular localization				18331300	1	1	1	as multiple sites (13PM) mutant 	
SP1	C2H2-type zinc finger protein; DNA binding protein; Transcription factor	Q01714	24790	Sp1		rat	T454	PHOSPHORYLATION	448226	SGPIIIRtPTVGPNG			transcription, induced			20655012	6	0	0	induced by carbon monoxide	
villin	Actin binding protein; Motility/polarity/chemotaxis	P09327	7429	VIL1	2q35	human	Y256	PHOSPHORYLATION	454007	LKAALKLyHVSDSEG		molecular association, regulation; intracellular localization	cytoskeletal reorganization	ACTB(INDUCES)		4155; 8883	2	0	0		
4E-T	Karyopherin; Nuclear import; Translation	Q9NRA8	56478	EIF4ENIF1	22q11.2	human	S752	PHOSPHORYLATION	26392102	PSADRDSsPTTNSKL		molecular association, regulation		4E-T(INDUCES)		26341738	1	2	0	required for processing bodies (PBs or P bodies) assembly	
TFCP2	DNA binding protein; Transcription factor	Q12800	7024	TFCP2	12q13	human	S309	PHOSPHORYLATION	7965105	SLGEGNGsPNHQPEP		activity, inhibited	cell cycle regulation; transcription, inhibited			15235207; 7889913	2	0	0		
YY1	C2H2-type zinc finger protein; Cell development/differentiation; Transcription factor	P25490	7528	YY1	14q	human	T378	PHOSPHORYLATION	1218234	RTHVRIHtGDRPYVC	Raffinose_syn; zf-H2C2_2	molecular association, regulation; intracellular localization			DNA(DISRUPTS)	10353936	1	6	34	in mitotic cells	
IFNGR1	Membrane protein, integral; Receptor, cytokine	P15261	15979	Ifngr1		mouse	Y467	PHOSPHORYLATION	454436	GKESLMGyRLTGEAQ		molecular association, regulation		SOCS1(INDUCES)		4305	1	0	1		
ARHGAP24	GTPase activating protein, Rac/Rho; Motility/polarity/chemotaxis	Q8N264	83478	ARHGAP24	4q22.1	human	S437	PHOSPHORYLATION	12518706	SGIVTNGsFSSSNAE		activity, induced	cytoskeletal reorganization			12482285	1	1	0	membrane blebbing	
SLC1A1	Membrane protein, integral; Membrane protein, multi-pass; Transporter	P51907	25550	Slc1a1		rat	T5	PHOSPHORYLATION	13204400	___MGKPtSSGCDWR		activity, inhibited				13164213	1	0	0		
Cx43	Channel, misc.; Membrane protein, integral; Membrane protein, multi-pass; Motility/polarity/chemotaxis	P08050	24392	Gja1		rat	S306	PHOSPHORYLATION	465459	RNYNKQAsEQNWANY	Connexin43	activity, induced				11270001	2	14	3	mutation of this site decreases single channel conductance and gating	
GSK3B	EC 2.7.11.1; EC 2.7.11.26; KINASE; Kinase, protein; Protein kinase, CMGC; Protein kinase, Ser/Thr (non-receptor)	P49841	2932	GSK3B	3q13.3	human	Y216	PHOSPHORYLATION	448569	RGEPNVSyICSRYYR	Pkinase	protein stabilization; molecular association, regulation; intracellular localization; protein conformation; enzymatic activity, induced	apoptosis, altered; apoptosis, induced; transcription, induced; transcription, altered; cell growth, altered	TCF4(INDUCES); axin 1(DISRUPTS)		2701903; 5640; 3638; 5683; 5601; 1111; 19016931; 2621612; 6011119	59	70	4190		
hnRNP L	RNA binding protein; RNA splicing	P14866	3191	HNRNPL	19q13.2	human	Y359	PHOSPHORYLATION	473633	HRRGPSRyGPQYGHP		protein stabilization; intracellular localization	translation, induced	hnRNP A2/B1(INDUCES)		28722436	1	2	9	suppresses nuclear translocation and cytoplasmic degradation, required for the heterotrimeric HILDA complex in operating the VGFA RNA  conformational switch	
CTCF	C2H2-type zinc finger protein; Transcription factor	Q08705	396274	CTCF		chicken	S612	PHOSPHORYLATION	448305	KKEDSSDsEENAEPD		activity, inhibited	transcription, induced; transcription, altered; cell growth, altered			1410; 7105	2	5	0	Phosphorylation mutant S612A inhibited transcriptional repression of transcription (CAT activity than wild-type CTCF. 

Phosphorylation mutant S612A showed transcriptional repression (CAT activity) not significantly different from wild-type after co-transfection with CK2. 

S612A  also did not significanty alter growth suppression of COS7 cells in comparison with wild-type.	
NEK9	Autophagy; EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor)	Q8TD19	91754	NEK9	14q24.3	human	S944	PHOSPHORYLATION	4272073	GQQVGMHsKGTQTAK		molecular association, regulation; enzymatic activity, induced	signaling pathway regulation	LC8(DISRUPTS); NEK6(INDUCES)		18668239	2	6	0		
PTEN	Carbohydrate Metabolism - inositol phosphate; EC 3.1.3.16; EC 3.1.3.48; EC 3.1.3.67; Motility/polarity/chemotaxis; Nuclear receptor co-regulator; PHOSPHATASE; Phosphatase, lipid; Tumor suppressor	P60484	5728	PTEN	10q23.3	human	T401	PHOSPHORYLATION	4695763	EDQHTQItKV_____		molecular association, regulation		MAST2(DISRUPTS); DLG1(DISRUPTS)		12482260	0	1	0		
BRAF	EC 2.7.1.37; EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, Ser/Thr (non-receptor); Protein kinase, TKL	P15056	673	BRAF	7q34	human	T753	PHOSPHORYLATION	460657	YACASPKtPIQAGGY		molecular association, regulation	cell growth, altered	RAF1(DISRUPTS)		7764; 12025500	3	2	0		
rabphilin 3A	Vesicle protein	P47708	19894	Rph3a		mouse	S271	PHOSPHORYLATION	455801	AGLRRANsVQAARPA		intracellular localization				6424	2	5	0		
ZAP70	EC 2.7.10.2; KINASE; Kinase, protein; Protein kinase, TK; Protein kinase, tyrosine (non-receptor)	P43403	7535	ZAP70	2q12	human	Y319	PHOSPHORYLATION	447587	TSVYESPySDPEELK		activity, induced; molecular association, regulation; phosphorylation	transcription, induced; transcription, altered	PLCG1(INDUCES); Lck(INDUCES)		5955628; 5700; 807; 806	26	5	280	Ca(2+) mobilization; Does not regulate integrin mediated adhesion.	
DOR-1	GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR	P32300	18386	Oprd1		mouse	T352	PHOSPHORYLATION	18321900	LRRPRQAtTRERVTA		intracellular localization				18119118	1	0	0		
SAV1	Adaptor/scaffold	Q9H4B6	60485	SAV1	14q13-q23	human	S269	PHOSPHORYLATION	21507301	YRHPCAPsVPRYDQP		protein conformation	apoptosis, induced			21386602	1	1	0	 self-dimerization; increase in protein level	
ChREBP	Transcription factor	Q8VIP2	171078	Mlxipl		rat	S568	PHOSPHORYLATION	451262	TLLRPPEsPDAVPEI		activity, inhibited	transcription, inhibited		DNA(DISRUPTS)	3480	1	2	0		
COPS6	Cell cycle regulation	Q7L5N1	10980	COPS6	7q22.1	human	S60	PHOSPHORYLATION	27166600	DHWIRMRsQEGRPVQ	Mov34	protein stabilization; ubiquitination	cell growth, induced			27623409; 27132406	2	0	0	involved in p57 degradation; Akt phosphorylation of S60 reduced ubiquitination of COPS6. S60D mutant induces p53 degradation and enhances transformation.  	
USP10	EC 3.1.2.15; EC 3.4.19.12; Protease; Ubiquitin conjugating system; Ubiquitin-specific protease	Q14694	9100	USP10	16q24.1	human	T42	PHOSPHORYLATION	12483201	SGTVLCGtQAVDKLP		protein stabilization; ubiquitination; intracellular localization	carcinogenesis, inhibited; cell growth, altered			13354740	1	0	0	regulates p53 homeostasis	
L-plastin	Actin binding protein; Motility/polarity/chemotaxis	P13796	3936	LCP1	13q14.3	human	S5	PHOSPHORYLATION	450852	___MARGsVSDEEMM		molecular association, regulation; intracellular localization	cytoskeletal reorganization; cell adhesion, altered	ITGB2(NOT_REPORTED); ACTA1(INDUCES)		9597; 7987; 12778817; 3138	8	24	5		
EGFR	EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Protein kinase, TK; Protein kinase, tyrosine (receptor)	P00533	1956	EGFR	7p12	human	Y1092	PHOSPHORYLATION	448057	TFLPVPEyINQSVPK		protein degradation; molecular association, regulation; phosphorylation; enzymatic activity, induced; activity, induced; ubiquitination; receptor internalization, altered; intracellular localization; protein conformation	apoptosis, inhibited; cell adhesion, altered; transcription, altered; cell growth, altered	Cbl(INDUCES); SOS1(INDUCES); RASA1(INDUCES); EGFR(INDUCES); STAT3(INDUCES); SHP-1(INDUCES); Grb2(INDUCES)	DNA(INDUCES)	2651; 660; 7071; 6783; 5181; 2310; 5489; 2852610; 4799; 4843014; 1064; 2309; 5886; 2641; 2311; 2981; 6086; 2852619; 9214500	84	16	326	EGFR  autophosphorylation sites modulate STAT activation. 	
TGFBR2	EC 2.7.11.30; KINASE; Kinase, protein; Membrane protein, integral; Protein kinase, Ser/Thr (receptor); Protein kinase, TKL	P37173	7048	TGFBR2	3p22	human	Y259	PHOSPHORYLATION	2869604	KGRFAEVyKAKLKQN	Pkinase	enzymatic activity, induced	transcription, altered			2852639	2	0	0		
Chk2	EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, CAMK; Protein kinase, Ser/Thr (non-receptor)	O96017	11200	CHEK2	22q12.1	human	Y390	PHOSPHORYLATION	17534901	TLCGTPTyLAPEVLV	Pkinase	intracellular localization; enzymatic activity, induced				15658725	1	1	0	chromatin targeting of S372, S379, T389, singly and T383/389, T378/S379	
STAT6	DNA binding protein; Transcription factor	P52633	20852	Stat6		mouse	Y641	PHOSPHORYLATION	447757	MGKDGRGyVSTTIKM		protein degradation; intracellular localization				6003	15	4	66		
MCPIP1	EC 3.1.-.-; Hydrolase	Q5D1E7	230738	Zc3h12a		mouse	S435	PHOSPHORYLATION	22730005	TSQECLDsGIGSLES		protein degradation; molecular association, regulation; ubiquitination	RNA stability, induced	BTRC(INDUCES)		22723924	1	0	0	phosphorylation followed by degradation of ZC3H12A (aka regnase-1) augments IL-6 mRNA stability	
Artemis	DNA repair; Deoxyribonuclease; EC 3.1.-.-	Q96SD1	64421	DCLRE1C	10p13	human	S645	PHOSPHORYLATION	457531	NLSTNADsQSSSDFE		molecular association, regulation; ubiquitination; intracellular localization	cell cycle regulation	FBXW7(INDUCES)		7730; 7889903; 9254	5	1	0	; facilitates recovery from the replication checkpoint in response to DNA damage; Artermis regulates Cdk1-cyclin B during IR-induced G2/M arrest and Cdk1-cyclin B nuclear import.;  interaction with FBXW7 stimulates ubiquitination and degradation of cyclin E	
DEF6	Guanine nucleotide exchange factor, Rac/Rho	Q8C2K1	23853	Def6		mouse	Y133	PHOSPHORYLATION	6094305	NFLSEDKyPLIMVPD		activity, induced; intracellular localization	cell differentiation, altered; transcription, altered			5960907	1	0	0		
HER2	EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Protein kinase, TK; Protein kinase, tyrosine (receptor)	P06494	24337	Erbb2		rat	Y879	PHOSPHORYLATION	448694	LDIDETEyHADGGKV	Pkinase_Tyr	molecular association, regulation; phosphorylation	cell growth, altered	EGFR(INDUCES)		4723; 2852642	17	8	90		
LIFR	Membrane protein, integral; Receptor, cytokine	P42702	3977	LIFR	5p13-p12	human	S1044	PHOSPHORYLATION	450385	WNLVSPDsPRSIDSN		protein degradation; intracellular localization; activity, inhibited				3091; 3309509; 8614	4	2	0		
ENaC-beta	Channel, sodium; Membrane protein, integral; Membrane protein, multi-pass	Q9WU38	20277	Scnn1b		mouse	T613	PHOSPHORYLATION	451219	QTLPIPGtPPPNYDS		activity, inhibited				762712	4	0	0	T613A mutation causes a reduced inhibitory response of EGF on reduction of short circuit current.  Most likely a change in open probability.	
FLOT2	Cell adhesion	Q14254	2319	FLOT2	17q11-q12	human	Y163	PHOSPHORYLATION	475941	DVYDKVDyLSSLGKT	Band_7		endocytosis, altered			7324301	3	1	18	regulates FLOT2 internalization	
RFA2	DNA replication	P15927	6118	RPA2	1p35	human	S4	PHOSPHORYLATION	470082	____MWNsGFESYGS		intracellular localization	cell cycle regulation; apoptosis, induced; cell growth, altered			21690611; 9042; 3335906; 2451816	15	1	0	 inhibits homologous recombination; delays mitotic entry	
MCM4	DNA replication; EC 3.6.4.12	P33991	4173	MCM4	8q11.2	human	T7	PHOSPHORYLATION	450000	_MSSPAStPSRRGSR		activity, inhibited				2551	2	0	0		
calsenilin	Calcium-binding protein; Transcription factor	Q9Y2W7	30818	KCNIP3	2q21.1	human	S95	PHOSPHORYLATION	471337	FTKKELQsLYRGFKN		intracellular localization				9105	1	0	0	inhibits trafficking of Kv4.2 potassium channels to the plasma membrane	
LPIN1	EC 3.1.3.4; Phosphatase, lipid	Q91ZP3	14245	Lpin1		mouse	S106	PHOSPHORYLATION	471342	IPMYLATsPILSEGA	Lipin_N	intracellular localization				9092	2	2	0		
JNK1	EC 2.7.11.24; KINASE; Kinase, protein; Protein kinase, CMGC; Protein kinase, Ser/Thr (non-receptor)	P45983	5599	MAPK8	10q11.22	human	Y185	PHOSPHORYLATION	447645	TSFMMTPyVVTRYYR	Pkinase	enzymatic activity, induced	apoptosis, altered; apoptosis, induced; cell adhesion, altered; transcription, altered			12482411; 7324138; 7036; 3278; 5121519	199	27	1233		
HMGN2	DNA binding protein	P05204	3151	HMGN2	1p36.1	human	S29	PHOSPHORYLATION	2574920	QRRSARLsAKPAPPK	HMG14_17	intracellular localization				8551	3	11	0	Phosphorylation facilitates localization to non-nuclear pools.	
RIP140	Nuclear receptor co-regulator; Transcription, coactivator/corepressor	Q8CBD1	268903	Nrip1		mouse	S102	PHOSPHORYLATION	3345202	AAKRKRLsDSIVNLN	Hexokinase_1	molecular association, regulation; methylation; intracellular localization	transcription, altered	14-3-3 beta(INDUCES); PRMT1(INDUCES)		3301209	1	1	0	regulates fat accumulation	
osteopontin	Secreted; Secreted, signal peptide	P10451	6696	SPP1	4q22.1	human	S129	PHOSPHORYLATION	455740	ESHHSDEsDELVTDF	Osteopontin	molecular association, regulation; activity, inhibited			Other(INDUCES)	10425106	1	4	0	peptide with phosphorylated S117, S120, S123, S126 and S129 has increased binding to hydroxyapatite, and inhibits bone mineralization in vivo and in vitro 	
PXN	Adaptor/scaffold; Cell adhesion; Cytoskeletal protein; Motility/polarity/chemotaxis	P49023	5829	PXN	12q24.31	human	S130	PHOSPHORYLATION	450228	KQKSAEPsPTVMSTS	Paxillin		cell motility, induced; cytoskeletal reorganization			27902332	5	14	4	HGF mediated  disassembly of focal adhesions and cell migration 	
Kidins220	Membrane protein, integral; Membrane protein, multi-pass; Protein kinase, regulatory subunit	Q9EQG6	116478	Kidins220		rat	Y1095	PHOSPHORYLATION	458291	PPRPPSGySQPASVC		molecular association, regulation		CrkL(INDUCES)		7312	1	0	0		
Mpl	Membrane protein, integral; Receptor, cytokine	Q08351	17480	Mpl		mouse	Y582	PHOSPHORYLATION	454722	PSQPQMDyRGLQPCL		activity, inhibited	cell growth, altered			12021327	1	2	15		
CCKAR	GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR	P30551	24889	Cckar		rat	S260	PHOSPHORYLATION	451123	QGIKFDAsQKKSAKE	7tm_1	receptor desensitization, altered				7712	2	0	0		
MST3	EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, STE; Protein kinase, Ser/Thr (non-receptor)	Q9Y6E0	8428	STK24	13q31.2-q32.3	human	T18	PHOSPHORYLATION	452058	ALNKRRAtLPHPGGS		activity, induced				4003	1	0	1		
ATP1A1	EC 3.6.3.9; Hydrolase; Membrane protein, integral; Membrane protein, multi-pass	P06685	24211	Atp1a1		rat	Y10	PHOSPHORYLATION	452054	KGVGRDKyEPAAVSE		activity, induced				3998	1	5	180		
PDGFRB	EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Protein kinase, TK; Protein kinase, tyrosine (receptor)	P09619	5159	PDGFRB	5q33.1	human	Y581	PHOSPHORYLATION	447519	SDGHEYIyVDPMQLP		molecular association, regulation; phosphorylation; enzymatic activity, induced	cell growth, altered	RASA1(INDUCES); PLCG1(INDUCES); PIK3R1(INDUCES)		2852641; 1225; 8841; 5011222	6	1	0		
Gab1	Adaptor/scaffold; Motility/polarity/chemotaxis	Q9QYY0	14388	Gab1		mouse	Y373	PHOSPHORYLATION	447945	ASDTDSSyCIPPPAG		molecular association, regulation	cell differentiation, altered; cell growth, altered	PLCG1(INDUCES)		1102	4	8	275		
NPM1	RNA binding protein; Translation	P06748	4869	NPM1	5q35.1	human	T234	PHOSPHORYLATION	449024	SFKKQEKtPKTPKGP	Nop14; TFIIF_alpha	molecular association, regulation; intracellular localization	cell cycle regulation		RNA(DISRUPTS)	2056; 836; 5607	4	9	14		
Ig-alpha	Immunoglobulin superfamily; Membrane protein, integral	P11911	12518	Cd79a		mouse	S197	PHOSPHORYLATION	21127303	CSMYEDIsRGLQGTY	ITAM	activity, inhibited				15755105	3	0	0	negatively regulates B-cell antigen receptor signaling	
IKKB	EC 2.7.11.10; KINASE; Kinase, protein; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor)	Q9QY78	84351	Ikbkb		rat	S181	PHOSPHORYLATION	447489	DQGSLCTsFVGTLQY	Pkinase	enzymatic activity, induced	cell growth, altered			6801	50	0	0		
ITK	EC 2.7.10.2; KINASE; Kinase, protein; Protein kinase, TK; Protein kinase, tyrosine (non-receptor)	Q03526	16428	Itk		mouse	Y517	PHOSPHORYLATION	447997	RFVLDDQyTSSTGTK	Pkinase_Tyr	phosphorylation; enzymatic activity, induced				2933	2	6	263	stimulates phosphorylation of ITK Y186 	
CYP2B6	Cofactor and Vitamin Metabolism - retinol; EC 1.14.14.1; Lipid Metabolism - arachidonic acid; Oxidoreductase; Xenobiotic Metabolism - drug metabolism - cytochrome P450; Xenobiotic Metabolism - metabolism by cytochrome P450	P00176	29295	Cyp2b1		rat	S128	PHOSPHORYLATION	448738	WKALRRFsLATMRDF	p450	intracellular localization; enzymatic activity, inhibited; protein conformation				13245303; 1898; 6296; 2032	2	1	0		
calpain 2	EC 3.4.22.53; Motility/polarity/chemotaxis; Protease	P17655	824	CAPN2	1q41-q42	human	S369	PHOSPHORYLATION	451303	DGNWRRGsTAGGCRN	Calpain_III	activity, inhibited	cell motility, altered			3527	1	0	2		
GABRB3	Channel, chloride; Channel, ligand-gated; Membrane protein, integral; Membrane protein, multi-pass	P15433	14402	Gabrb3		mouse	S432	PHOSPHORYLATION	450245	KTHLRRRsSQLKIKI	Neur_chan_memb	molecular association, regulation		AP-2 alpha(DISRUPTS)		1968324	8	0	0		
FOXO1A	DNA binding protein; Nuclear receptor co-regulator; Transcription factor	Q12778	2308	FOXO1	13q14.1	human	S298	PHOSPHORYLATION	471972	QFSKWPAsPGSHSND		intracellular localization	transcription, altered			12525214	5	5	26	multiple site mutant (8A)	
PGC-1 alpha	Nuclear receptor co-regulator; Transcription, coactivator/corepressor	O70343	19017	Ppargc1a		mouse	S194	PHOSPHORYLATION	13861601	SWSNKAKsICQQQKP		intracellular localization	transcription, induced			13354730	1	0	0		
p90RSK	EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor); Translation	Q63531	81771	Rps6ka1		rat	S221	PHOSPHORYLATION	447988	DHEKKAYsFCGTVEY	Pkinase	molecular association, regulation; enzymatic activity, inhibited	apoptosis, inhibited	PKAR1A(INDUCES)		13270515	9	21	84		
vimentin	Cytoskeletal protein; Motility/polarity/chemotaxis	P08670	7431	VIM	10p13	human	S83	PHOSPHORYLATION	451816	GVRLLQDsVDFSLAD	Filament_head; DUF2464; DUF3584; TPR_MLP1_2		cell motility, altered			3475712	12	14	0	cell invasiveness	
CACNA1B iso2	Channel, calcium; Membrane protein, integral; Membrane protein, multi-pass	Q6XS92	257648	Cacna1b		rat	Y52	PHOSPHORYLATION	14080100	RIHYKDMySLLRCIA		activity, inhibited				14080200	1	0	0	voltage-dependent inhibition of channel currents	
S6	Translation	P62754	20104	Rps6		mouse	S244	PHOSPHORYLATION	448095	LRASTSKsESSQK__			carcinogenesis, induced			27519661	52	16	558	Increased Kras induced pancreatic lesions, metaplastic foci, p53 expression	
DGKK	EC 2.7.1.107; Kinase, lipid	Q5KSL6	139189	DGKK	Xp11.22	human	Y78	PHOSPHORYLATION	457633	SESATELyTEPTPEP		enzymatic activity, inhibited				6979	1	0	0		
BRAF	EC 2.7.1.37; EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, Ser/Thr (non-receptor); Protein kinase, TKL	Q04982	396239	BRAF		chicken	S769	PHOSPHORYLATION	450242	PKIHRSAsEPSLNRA		molecular association, regulation; enzymatic activity, induced		14-3-3 beta(INDUCES)		7878	4	26	25	effect on kinase activity measured in vitro	
MAVS	Adaptor/scaffold; Membrane protein, integral	Q7Z434	57506	MAVS	20p13	human	T234	PHOSPHORYLATION	3204129	FQPLARStPRASRLP		molecular association, regulation		PLK1(INDUCES)		9158111	1	1	1		
p300	ACETYLTRANSFERASE; Acetyltransferase; EC 2.3.1.48; Motility/polarity/chemotaxis; Nuclear receptor co-regulator; Transcription, coactivator/corepressor	Q09472	2033	EP300	22q13.2	human	S1834	PHOSPHORYLATION	447591	MLRRRMAsMQRTGVV		molecular association, regulation	transcription, induced	CAF-1A(INDUCES)		6898	5	0	0		
RFC1	DNA replication	D3ZFT1	89809	Rfc1		rat	S71	PHOSPHORYLATION	452681	RIIYDSDsESEETVQ		intracellular localization	transcription, inhibited			8890	1	33	4		
TWIST1	Cell development/differentiation; DNA binding protein; Inhibitor protein; Transcription regulation	P26687	22160	Twist1		mouse	S42	PHOSPHORYLATION	14821304	GARKRRSsRRSAGGS			carcinogenesis, induced			14780534	1	1	0		
SLC9A5	Membrane protein, integral; Membrane protein, multi-pass; Transporter	Q14940	6553	SLC9A5	16q22.1	human	S709	PHOSPHORYLATION	20832304	SEEEEEEsDSSETEK		molecular association, regulation; activity, inhibited	endocytosis, induced	ARRB1(INDUCES)		20655009	1	0	0	In intact cells ARRB1 ST/AA mutant retained ability to form a complex. 	
PXN iso2	Adaptor/scaffold; Cell adhesion; Cytoskeletal protein; Motility/polarity/chemotaxis	P49023-2	5829	PXN	12q24.31	human	Y118	PHOSPHORYLATION	448604	VGEEEHVySFPNKQK	Paxillin	activity, induced; protein degradation; molecular association, regulation; phosphorylation	cell cycle regulation; apoptosis, altered; cell motility, altered; cytoskeletal reorganization; transcription, altered	Src(INDUCES); CrkL(INDUCES)		15022718; 3394329; 2466211; 6675; 11807; 9180; 2051; 6115915	55	48	2522	essential for EGFR-mediated Erk1/2 activation and cell proliferation	
PDX1	DNA binding protein; Transcription factor	P52946	18609	Pdx1		mouse	T231	PHOSPHORYLATION	13421407	PEQDCAVtSGEELLA			transcription, inhibited			13359110	1	0	0		
p53	Activator protein; DNA binding protein; Motility/polarity/chemotaxis; Nuclear receptor co-regulator; Transcription factor; Tumor suppressor	P02340	22059	Tp53		mouse	K375	UBIQUITINATION	464657	GQSTSRHkKTMVKKV			transcription, altered			3141407	11	0	0	p53K6R (K378/383/369/379/367/370/R) mutant is still ubiquitinated and shows normal stability of p53 before and after DNA damage	
MEF2A	DNA binding protein; Motility/polarity/chemotaxis; Transcription factor	Q02078	4205	MEF2A	15q26	human	S355	PHOSPHORYLATION	449934	SALQGFNsPGMLSLG		activity, induced				2504	1	0	0		
ENPP1	Carbohydrate Metabolism - starch and sucrose; Cofactor and Vitamin Metabolism - nicotinate and nicotinamide; Cofactor and Vitamin Metabolism - pantothenate and CoA biosynthesis; Cofactor and Vitamin Metabolism - riboflavin; EC 3.1.4.1; EC 3.6.1.9; KINASE; Membrane protein, integral; Motility/polarity/chemotaxis; Nucleotide Metabolism - purine; Phosphatase (non-protein); Phosphodiesterase	Q924C3	85496	Enpp1		rat	T238	PHOSPHORYLATION	451402	RPVYPTKtFPNHYSI	Phosphodiest	enzymatic activity, inhibited				3552	1	4	1		
HDAC2	DEACETYLASE; Deacetylase; EC 3.5.1.98; Nuclear receptor co-regulator; Transcription, coactivator/corepressor	Q92769	3066	HDAC2	6q21	human	S394	PHOSPHORYLATION	449930	EDAVHEDsGDEDGED		acetylation; molecular association, regulation; enzymatic activity, inhibited; enzymatic activity, induced		p53(INDUCES); HDAC1(INDUCES); SIN3A(INDUCES); CHD-3 iso3(INDUCES)		13354700; 2499	3	43	49		
MEF2C iso3	DNA binding protein; Transcription factor	Q06413-3	4208	MEF2C	5q14.3	human	T300	PHOSPHORYLATION	448001	TPVVSVAtPTLPGQG		activity, induced	transcription, altered			2273	1	0	0		
IRE1	Apoptosis; Chaperone; EC 2.7.11.1; EC 3.1.26.-; Endoplasmic reticulum; KINASE; Kinase, protein; Membrane protein, integral; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor); Ribonuclease	O75460	2081	ERN1	17q24.2	human	S724	PHOSPHORYLATION	7161100	KLAVGRHsFSRRSGV	Pkinase	enzymatic activity, induced	transcription, altered			7160600	4	0	0	Sustained activation of IRE (25 days) decreases insulin expression.	
FADD	Adaptor/scaffold; Apoptosis	Q61160	14082	Fadd		mouse	S191	PHOSPHORYLATION	447653	VSKSENMsPVLRDST		intracellular localization	cell cycle regulation; apoptosis, induced; cell growth, altered			2209; 1163203; 6736	12	16	0		
IkB-beta	Inhibitor protein	Q60778	18036	Nfkbib		mouse	S19	PHOSPHORYLATION	447917	DADEWCDsGLGSLGP		protein degradation				5520; 3970006	5	0	0		
RAF1	EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, Ser/Thr (non-receptor); Protein kinase, TKL	P04049	5894	RAF1	3p25	human	S259	PHOSPHORYLATION	447741	SQRQRSTsTPNVHMV		molecular association, regulation; intracellular localization; enzymatic activity, inhibited; phosphorylation	cell growth, altered	14-3-3 beta(INDUCES); 14-3-3 theta(INDUCES); 14-3-3 zeta(INDUCES); HRas(DISRUPTS); PPP2CB(DISRUPTS)		5708; 18378516; 5121521; 6647; 5121526; 6879; 5978; 2513; 6878; 14654306; 5955; 14151807	44	13	128		
MAD2L1	Cell cycle regulation	Q13257	4085	MAD2L1	4q27	human	S178	PHOSPHORYLATION	11280300	GPQFITNsEEVRLRS	HORMA; ATG13	molecular association, regulation	cell cycle regulation	Mad1(DISRUPTS)		10294003	2	0	0		
H2A.1	DNA binding protein	P0C0S8	8329	HIST1H2AI	6p22.1	human	S2	PHOSPHORYLATION	451190	______MsGRGKQGG		activity, inhibited	transcription, inhibited			3359	2	2	0		
p40phox	Oxidoreductase	P97369	17972	Ncf4		mouse	T154	PHOSPHORYLATION	448266	LRRLRPRtRKIKGVS		intracellular localization				17613007	3	0	0	 translocation to S aureus phagosomes; essential for NADPH oxidase activity	
MDH2	Carbohydrate Metabolism - citrate (TCA) cycle; Carbohydrate Metabolism - glyoxylate and dicarboxylate; Carbohydrate Metabolism - pyruvate; EC 1.1.1.37; Mitochondrial; Oxidoreductase	P40926	4191	MDH2	7cen-q22	human	K314	ACETYLATION	466434	KVSSFEEkMISDAIP	Ldh_1_C	enzymatic activity, induced				12513600	0	5	8		
Kir6.2	Channel, potassium; Membrane protein, integral; Membrane protein, multi-pass	P70673		Kcnj11		rat	S385	PHOSPHORYLATION	2103601	AKPKFSIsPDSLS__			exocytosis, altered			7549207	2	1	0	regulates insulin secretion	
Cbl	Adaptor/scaffold; EC 6.3.2.-; EC 6.3.2.19; Ligase; Motility/polarity/chemotaxis; UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase	P22681	867	CBL	11q23.3	human	Y371	PHOSPHORYLATION	449753	TQEQYELyCEMGSTF		protein degradation; molecular association, regulation	cell cycle regulation; apoptosis, altered; cell growth, altered	Crk(INDUCES)		6422; 659; 18792800; 2012	5	5	72		
GFAT	Amino Acid Metabolism - alanine, aspartate and glutamate; Carbohydrate Metabolism - amino sugar and nucleotide sugar; EC 2.6.1.16; Transferase	Q06210	2673	GFPT1	2p13	human	S261	PHOSPHORYLATION	467935	CNLSRVDsTTCLFPV		enzymatic activity, induced				970050	2	39	492		
SREBP-1	DNA binding protein; Membrane protein, integral; Membrane protein, multi-pass; Transcription factor	P36956	6720	SREBF1	17p11.2	human	S439	PHOSPHORYLATION	469115	AGSPFQSsPLSLGSR		protein stabilization	cell cycle regulation; transcription, induced			8242	1	0	0	specific for mitotic cells regulates G1/S cell cycle 	
SRF	Motility/polarity/chemotaxis; Transcription factor	P11831	6722	SRF	6p21.1	human	S83	PHOSPHORYLATION	451800	YSGSEGDsESGEEEE		molecular association, regulation			DNA(INDUCES)	1646	3	5	0		
PPP2CA	EC 3.1.3.16; Motility/polarity/chemotaxis; PHOSPHATASE; Protein phosphatase, Ser/Thr (non-receptor)	P67775	5515	PPP2CA	5q31.1	human	Y307	PHOSPHORYLATION	448571	VTRRTPDyFL_____		molecular association, regulation; methylation; intracellular localization; enzymatic activity, inhibited	apoptosis, altered; cytoskeletal reorganization; cell growth, altered	LCMT1(INDUCES); JAK2(DISRUPTS); PPP2R3A(DISRUPTS); PPP2R5D(NOT_REPORTED); PPP2R2A(DISRUPTS); PPP2R5A(NOT_REPORTED)		18410800; 15754000; 2662; 9407; 15026104; 11803; 3029; 7543529; 14790315	40	0	0		
GLI3	C2H2-type zinc finger protein; Transcription factor	P10071	2737	GLI3	7p13	human	S865	PHOSPHORYLATION	15501379	YLSSRRSsGISPCFS		protein processing	transcription, inhibited			25779400	1	0	4		
PLK2	EC 2.7.11.21; KINASE; Kinase, protein; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor)	Q9R012	83722	Plk2		rat	T236	PHOSPHORYLATION	25790901	PLEHRRRtICGTPNY	Pkinase	enzymatic activity, induced				25785426	2	0	0		
EFNB2	Ligand, receptor tyrosine kinase; Membrane protein, integral	P52799	1948	EFNB2	13q33	human	Y316	PHOSPHORYLATION	447830	GDYGHPVyIVQEMPP	Shisa	protein stabilization; protein conformation				2363	2	7	107		
PPP2R5D	Motility/polarity/chemotaxis; Protein phosphatase, regulatory subunit	Q7TNL5	21770	Ppp2r5d		mouse	S81	PHOSPHORYLATION	468499	VKKERRQsSFPFNLN		enzymatic activity, induced				12778805	3	13	102		
GOLGA3	Vesicle protein	P55937	269682	Golga3		mouse	S174	PHOSPHORYLATION	487482	VKRHRERsSQPATKM			apoptosis, altered			12260	1	0	0	protected against Brefeldin-A-induced apoptosis, but not Fas-mediated apoptosis.	
IREM-1	Immunoglobulin superfamily; Membrane protein, integral; Receptor, misc.	Q8TDQ1	146722	CD300LF	17q25.1	human	Y205	PHOSPHORYLATION	474545	PLEGDLCyADLTLQL		activity, induced; molecular association, regulation		SHP-1(INDUCES)		9313; 9304	2	0	0		
SKAP55	Adaptor/scaffold; Motility/polarity/chemotaxis	Q86WV1	8631	SKAP1	17q21.32	human	Y295	PHOSPHORYLATION	460296	TRRKGVDyASYYQGL		molecular association, regulation	cell adhesion, altered; transcription, altered	SLP76(DISRUPTS)		7701	1	0	0	mutation of this site downregulates activity of IL-2 promoter and cytokine production	
SP7	C2H2-type zinc finger protein; DNA binding protein; Transcription factor	Q8VI67	170574	Sp7		mouse	S73	PHOSPHORYLATION	15334100	SSTNGLLsPAGSPPA		activity, induced; molecular association, regulation	transcription, altered	SMARCA4(INDUCES); p300(INDUCES)		15235204	1	0	0		
BubR1	EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor)	O60566	701	BUB1B	15q15	human	S670	PHOSPHORYLATION	3207630	TLSIKKLsPIIEDSR		molecular association, regulation	cell cycle regulation; cytoskeletal reorganization	PPP2R5A(INDUCES); PPP2CA(INDUCES)		27519650; 27132456; 13159707; 5358603	4	18	0	;  T680 is independent of attachment status and may correlate with lack of interkinetochore tension.;  pS670 Ab delayed anaphase onset in vivo and in vitro; phosphorylated at kinetochores at the onset of mitosis; regulates chromosome congression; chromosome segregation during mitosis and mitotic progression; kinetochore-microtubule attachment	
Bcl-xL	Apoptosis; Autophagy; Membrane protein, integral; Mitochondrial	P53563	24888	Bcl2l1		rat	S62	PHOSPHORYLATION	449099	PSWHLADsPAVNGAT			apoptosis, altered			5014014	10	1	0		
GRF-1	GTPase activating protein, Rac/Rho; Motility/polarity/chemotaxis; Transcription factor	Q91YM2	232906	Grlf1		mouse	Y1105	PHOSPHORYLATION	448941	RNEEENIySVPHDST		molecular association, regulation		RASA1(INDUCES)		7324134	2	47	3246		
CREB	DNA binding protein; Transcription factor	P16220	1385	CREB1	2q34	human	S129	PHOSPHORYLATION	450092	QKRREILsRRPSYRK	pKID	molecular association, regulation	cell growth, induced; transcription, induced	MEIS1(INDUCES)		15031316	10	0	2		
Kv4.2	Channel, potassium; Membrane protein, integral; Membrane protein, multi-pass	Q9Z0V2	16508	Kcnd2		mouse	T607	PHOSPHORYLATION	457612	IPTPPVTtPEGDDRP		activity, induced				6999	4	0	0	the T607D mutant effects required KChIP3 coexpression. Mutation with 3 residues mutated to D decreased the transient outward K+ current and showed higher activation voltage. 	
CLOCK	ACETYLTRANSFERASE; Acetyltransferase; DNA binding protein; EC 2.3.1.48; Transcription factor	O15516	9575	CLOCK	4q12	human	S437	PHOSPHORYLATION	11087839	PSASSRSsRKSSHTA		protein degradation				12021324	1	0	1		
Mnk1	EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, CAMK; Protein kinase, Ser/Thr (non-receptor); Translation	O08605	17346	Mknk1		mouse	T344	PHOSPHORYLATION	447623	APERGLPtPQVLQRN		enzymatic activity, induced	translation, altered; cell growth, altered			3394317	3	1	10		
PhLP	G protein regulator, misc.	Q63737	64013	Pdcl		rat	S18	PHOSPHORYLATION	448823	EKLQYYYsTSEDEDS		activity, inhibited				1996	3	4	2		
FOXO1A	DNA binding protein; Nuclear receptor co-regulator; Transcription factor	Q12778	2308	FOXO1	13q14.1	human	K262	ACETYLATION	4253200	ASMDNNSkFAKSRSR	Fork_head	intracellular localization; phosphorylation				15022750	2	0	0		
Snail2	Apoptosis; C2H2-type zinc finger protein; Motility/polarity/chemotaxis; Transcription factor	P97469	20583	Snai2		mouse	S4	PHOSPHORYLATION	25525401	____MPRsFLVKKHF	CTNNB1_binding		transcription, inhibited			25347023	1	0	0	regulates epithelial to mesenchymal  transition (EMT)	
H3	DNA binding protein	P68431	8350	HIST1H3A	6p22.1	human	S29	PHOSPHORYLATION	455677	ATKAARKsAPATGGV			transcription, induced			20655004	38	6	0		
Fos	DNA binding protein; Motility/polarity/chemotaxis; Transcription factor	P12841	314322	Fos		rat	S374	PHOSPHORYLATION	448482	PSSDSLSsPTLLAL_		protein stabilization; protein conformation; phosphorylation	cell cycle regulation; transcription, altered			1023; 2626208; 1021; 8510	8	1	0		
SLC12A3	Membrane protein, integral; Membrane protein, multi-pass; Transporter	P59158	20497	Slc12a3		mouse	T48	PHOSPHORYLATION	4709842	SHLTHGStLYMRTFG	AA_permease_N	activity, induced; phosphorylation				23265309	2	2	0	increases NCCT protein abundance and its phosphorylation by activated OSR1  	
PAK3	EC 2.7.1.; EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, STE; Protein kinase, Ser/Thr (non-receptor)	O75914	5063	PAK3	Xq23	human	T436	PHOSPHORYLATION	448126	PEQSKRStMVGTPYW	Pkinase		cytoskeletal reorganization			9007	3	2	9	Mutation of any of the 4 serines/threonines to alanine reduced the AILIM/ICOS-induced elongation ratio in activated T cells.  Three sites are believed to be autophosphorylation sites, and one is believed to be an Akt1 site.  Treatment with Akt inhibitor shows a reduction in this elongation ratio.	
Dok1	Adaptor/scaffold; Motility/polarity/chemotaxis	Q99704	1796	DOK1	2p13	human	S450	PHOSPHORYLATION	454885	SHNSALYsQVQKSGA		phosphorylation	cell motility, altered; cell growth, altered			4367	1	0	1		
ARHGAP42	GTPase activating protein, Rac/Rho	B2RQE8	71544	Arhgap42		mouse	Y342	PHOSPHORYLATION	450878	MDGKEPIyTLPAIIS			cell cycle regulation; cell motility, altered			2790302	0	8	251		
KCNJ12	Membrane protein, integral; Membrane protein, multi-pass	Q14500	3768	KCNJ12	17p11.2	human	T38	PHOSPHORYLATION	3053610	FGNGKVHtRRRCRNR	IRK_N	activity, inhibited				8595	1	0	0		
CFTR	Channel, chloride; EC 3.6.3.49; Hydrolase; Membrane protein, integral; Membrane protein, multi-pass; Transporter	P13569	1080	CFTR	7q31.2	human	S768	PHOSPHORYLATION	455300	LQARRRQsVLNLMTH	CFTR_R	activity, induced; molecular association, regulation; enzymatic activity, inhibited; activity, inhibited		CFTR(INDUCES)		7324312; 17431519; 4474; 7910511; 5930037; 4394	10	2	0	enhances the F3+ binding affinity	
IGF1R	EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Protein kinase, TK; Protein kinase, tyrosine (receptor)	Q60751	16001	Igf1r		mouse	Y1167	PHOSPHORYLATION	448387	RDIYETDyYRKGGKG	Pkinase_Tyr	enzymatic activity, induced	cell cycle regulation; cell motility, altered			2500; 2790302	11	28	697		
SGK1	EC 2.7.11.1; KINASE; Kinase, protein; Motility/polarity/chemotaxis; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor)	O00141	6446	SGK1	6q23	human	S78	PHOSPHORYLATION	448430	ANPSPPPsPSQQINL	Mito_fiss_reg		cell cycle regulation			1270	2	2	0		
tau	Cytoskeletal protein	P19332	29477	Mapt		rat	S546	PHOSPHORYLATION	449080	VVRTPPKsPSASKSR			cytoskeletal reorganization			4214826	31	19	22		
PGC-1 alpha	Nuclear receptor co-regulator; Transcription, coactivator/corepressor	O70343	19017	Ppargc1a		mouse	T177	PHOSPHORYLATION	486319	NHTHRIRtNPAIVKT			transcription, altered			12059	1	1	0		
IL9R	Membrane protein, integral; Receptor, cytokine	Q01113	3581	IL9R	Xq28 and Yq12	human	S518	PHOSPHORYLATION	450656	SVLSKARsWTF____		molecular association, regulation		14-3-3 zeta(INDUCES)		3123	0	0	0		
PhLP	G protein regulator, misc.	Q63737	64013	Pdcl		rat	T19	PHOSPHORYLATION	448824	KLQYYYStSEDEDSD		activity, inhibited				1996	3	3	3		
Kv7.2	Channel, potassium; Membrane protein, integral; Membrane protein, multi-pass	O88943	170848	Kcnq2		rat	T217	PHOSPHORYLATION	457689	RMDRRGGtWKLLGSV	Ion_trans; TM	activity, induced				10296903	2	1	0	Mutants showed reduced currents induced by acetylcholine.	
RIL	Cytoskeletal protein	P70271	30794	Pdlim4		mouse	S119	PHOSPHORYLATION	468635	PATSRRSsVSGISLE			cell growth, inhibited			20540234	2	18	10		
SH2-B-beta	Adaptor/scaffold	Q62985-2	89817	Sh2b1		rat	Y439	PHOSPHORYLATION	448753	DRLSQGAyGGLSDRP			cell motility, induced; cytoskeletal reorganization			1921; 27619352	2	0	1	membrane ruffling; macrophage migration	
PKCD	EC 2.7.10.2; EC 2.7.11.13; KINASE; Kinase, protein; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor)	P28867	18753	Prkcd		mouse	S662	PHOSPHORYLATION	447580	QEAFHGFsFVNPKFE	Pkinase_C	intracellular localization				5201	7	31	58		
CK1A	EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, CK1; Protein kinase, Ser/Thr (non-receptor)	P48729	1452	CSNK1A1	5q32	human	S242	PHOSPHORYLATION	11333101	KISEKKMsTPVEVLC	Pkinase	molecular association, regulation		14-3-3 eta(INDUCES)		11270022	1	0	0		
survivin	Apoptosis	O15392	332	BIRC5	17q25	human	K129	ACETYLATION	25558401	KEFEETAkKVRRAIE		molecular association, regulation; intracellular localization		STAT3(INDUCES); survivin(INDUCES); exportin 1(DISRUPTS)		25558100	1	1	0	observed in dbSNP K129G mutant protein	
AVPR2	GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR	P30518	554	AVPR2	Xq28	human	S364	PHOSPHORYLATION	451069	SCTTASSsLAKDTSS		intracellular localization				3288	1	0	0	After receptor activation, phosphorylation of serines  362, 363, and 364 inhibits overall dephosphorylation of the internalized receptor, thereby inhibiting recycling of the receptor to the cell surface.	
p90RSK	EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor); Translation	P18653	20111	Rps6ka1		mouse	T348	PHOSPHORYLATION	447992	DTEFTSRtPRDSPGI	Pkinase_C	enzymatic activity, induced				3231	35	11	2		
p70S6K iso2	EC 2.7.11.-; EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor); Translation	P67999-2	83840	Rps6kb1		rat	T421	PHOSPHORYLATION	448358	RFIGSPRtPVSPVKF		activity, induced	cell growth, altered			6939	94	16	84	PI3K, Akt and mTOR activation are required for 5-HT-induced proliferatioin. Wortmanin LY294002 and NL-71-101 dose-dependently inhibited 5HT induced proliferation. 	
RPS10	Ribosomal protein; Translation	P46783	6204	RPS10	6p21.31	human	R158	METHYLATION	13906404	QFRGGFGrGRGQPPQ		protein stabilization; molecular association, regulation; intracellular localization		NPM1(INDUCES)		13326311	1	0	0	 localization in the granular component (GC) region of the nucleolus; efficient assembly of RPS10 into ribosomes and protein synthesis	
PR	DNA binding protein; Nuclear receptor	P06401	5241	PGR	11q22-q23	human	S190	PHOSPHORYLATION	447986	KVLPRGLsPARQLLL	Prog_receptor		transcription, induced			7324125	6	1	0		
Kv1.3	Channel, potassium; Membrane protein, integral; Membrane protein, multi-pass	P22001	3738	KCNA3	1p13.3	human	Y499	PHOSPHORYLATION	451294	EGEEQSQyMHVGSCQ		activity, induced; activity, inhibited				3518; 6331318	2	0	0		
Myc	DNA binding protein; Transcription factor	P01108	17869	Myc		mouse	S62	PHOSPHORYLATION	448586	LLPTPPLsPSRRSGL	Myc_N	protein stabilization; molecular association, regulation; phosphorylation	transcription, altered	Pin1(INDUCES)		4677	33	12	28		
Cx50	Channel, misc.; Membrane protein, integral; Membrane protein, multi-pass	P36381	395846	GJA8		chicken	S364	PHOSPHORYLATION	465560	KAEEEVVsDEVEGPS		protein degradation; protein stabilization				8023; 3301213	2	1	0	phosphorylation of this site blocks Cx50 from the cleavage by caspase-3	
merlin	Cytoskeletal protein; Motility/polarity/chemotaxis	P35240	4771	NF2	22q12.2	human	S518	PHOSPHORYLATION	448282	DTDMKRLsMEIEKEK	ERM	molecular association, regulation; intracellular localization; protein conformation; activity, inhibited; phosphorylation	cell cycle regulation; cell motility, altered; cell adhesion, altered; cytoskeletal reorganization; transcription, altered; cell growth, altered	merlin(INDUCES); DDB1(DISRUPTS); CD44(DISRUPTS); SPTAN1(INDUCES); TUBA4A(DISRUPTS); ezrin(INDUCES); PIK3R2(DISRUPTS); Src(DISRUPTS); Hrs(DISRUPTS); VPRBP(DISRUPTS); merlin(DISRUPTS)		1700; 14148620; 1713127; 3342624; 7171; 4647; 9388; 1345; 4917213; 9981400; 4917214; 2590901; 4564	21	17	1		
TXA2-R	GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR	P21731	6915	TBXA2R	19p13.3	human	S329	PHOSPHORYLATION	450989	RLSTRPRsLSLQPQL		receptor desensitization, altered				3230	3	4	2	TXA2-R alpha is subject to cross-desensitization by the prostacyclin receptor which is mediated through direct PKA phosphorylation of S329.	
ATRIP	Cell cycle regulation; DNA binding protein; DNA repair	Q8WXE1	84126	ATRIP	3p21.31	human	S239	PHOSPHORYLATION	485777	VIKPEACsPQFGKTS			cell cycle regulation	BRCA1(INDUCES)		12088	1	5	13	required for checkpoint function	
STAT3	DNA binding protein; Motility/polarity/chemotaxis; Nuclear receptor co-regulator; Transcription factor	P40763	6774	STAT3	17q21.31	human	Y705	PHOSPHORYLATION	448192	DPGSAAPyLKTKFIC		activity, induced; protein degradation; molecular association, regulation; intracellular localization; phosphorylation	cell differentiation, altered; cell growth, induced; apoptosis, inhibited; cell motility, altered; transcription, induced; cell adhesion, altered; transcription, altered; cell growth, altered	PKCD(INDUCES); STAT1(INDUCES)	DNA(INDUCES)	5848; 2539700; 4313606; 2670114; 4313628; 2705902; 2703107; 5410109; 4214809; 8475007; 1827; 14654312; 6115905; 5410117; 25560100; 5704; 6426; 5581; 5699; 6409; 5582; 3346104; 5174; 6440; 2704330; 4789; 5918; 2365404; 6915; 6420301	251	36	3028	translocation to the nucleus; PKM2 R399E  mutant has higher activity, increasing STAT3 phosphorylation and inducing cell proliferation. Upregulates MEK5 transcription. ; FGFR2-STAT3 pathway activation-nuclear localization	
PXR	DNA binding protein; Nuclear receptor	O75469	8856	NR1I2	3q12-q13.3	human	T57	PHOSPHORYLATION	6370304	GYHFNVMtCEGCKGF	zf-C4	molecular association, regulation; intracellular localization; activity, inhibited	transcription, altered; transcription, inhibited		DNA(NOT_REPORTED); DNA(DISRUPTS)	9689411; 6331319	3	0	0	inhibits transcription; PXR T57D (but not T57A) mutant fails to bind to the CYP3A4 promoter 	
AATF	Transcription factor	Q9NY61	26574	AATF	17q12	human	S189	PHOSPHORYLATION	3753300	EGDDAEDsQGESEED		protein stabilization; molecular association, regulation	apoptosis, inhibited; transcription, altered	NFkB-p65(INDUCES)	DNA(INDUCES)	9225	1	0	0		
NMDAR2A	Channel, ligand-gated; Membrane protein, integral; Membrane protein, multi-pass	P35436	14811	Grin2a		mouse	S1462	PHOSPHORYLATION	3597310	KKMPSIEsDV_____	NMDAR2_C	molecular association, regulation		PSD-95(NOT_REPORTED)		9186	1	2	0	effects PKC potentiation of current	
Mpl	Membrane protein, integral; Receptor, cytokine	Q08351	17480	Mpl		mouse	S541	PHOSPHORYLATION	3091400	LRDTAALsPSKATVT		activity, induced; phosphorylation	cell growth, altered			8388	1	0	0	tyrosine phosphorylation of JAK2	
P2X3	Channel, ligand-gated; Membrane protein, integral; Membrane protein, multi-pass	P56373	5024	P2RX3	11q12	human	T196	PHOSPHORYLATION	458893	GNLLPNLtARDMKTC	P2X_receptor	receptor desensitization, altered				7456	1	0	1		
DAB1	Adaptor/scaffold	P97318	13131	Dab1		mouse	Y185	PHOSPHORYLATION	447959	KQCEQAVyQTILEED		intracellular localization	cell motility, altered; cytoskeletal reorganization			6498; 10425111	5	0	0		
PFKFB3	Carbohydrate Metabolism - fructose and mannose; EC 2.7.1.105; EC 3.1.3.46; Kinase, other; Motility/polarity/chemotaxis; Phosphatase (non-protein)	Q16875	5209	PFKFB3	10p15.1	human	S461	PHOSPHORYLATION	448801	NPLMRRNsVTPLASP		enzymatic activity, induced				7264	4	22	74		
SRPK1	EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, CMGC; Protein kinase, Ser/Thr (non-receptor)	Q96SB4	6732	SRPK1	6p21.31	human	S587	PHOSPHORYLATION	25724400	LIVAGKYsKEFFTKK	Pkinase	intracellular localization	RNA splicing, induced			25712626	1	1	0	translocation to the nucleus-regulation of E1A splicing	
NKCC2	Membrane protein, integral; Membrane protein, multi-pass; Transporter	P55014	20495	Slc12a1		mouse	S126	PHOSPHORYLATION	478420	GPKVNRPsLLEIHEQ	AA_permease_N	activity, induced				9588	4	1	0	upregulates salt re-absorption under isotonic conditions	
EphA3	EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Protein kinase, TK; Protein kinase, tyrosine (receptor)	P29319	13837	Epha3		mouse	Y596	PHOSPHORYLATION	449912	KLPGLRTyVDPHTYE		enzymatic activity, induced				15278817	3	6	39		
ITK	EC 2.7.10.2; KINASE; Kinase, protein; Protein kinase, TK; Protein kinase, tyrosine (non-receptor)	Q08881	3702	ITK	5q31-q32	human	Y512	PHOSPHORYLATION	447997	RFVLDDQyTSSTGTK	Pkinase_Tyr	activity, induced				1632	2	6	263		
Myf-6	DNA binding protein; Transcription factor	P15375	17878	Myf6		mouse	S42	PHOSPHORYLATION	2907503	PGSDGTLsPCQDQMP	Basic		cell differentiation, altered; transcription, inhibited			8651	1	0	0		
RCC1	Guanine nucleotide exchange factor, Ras	P18754	1104	RCC1	1p36.1	human	S26	PHOSPHORYLATION	2850002	KSKKVKVsHRSHSTE		molecular association, regulation		KPNA4(DISRUPTS)		2831773	1	0	0		
BRCA2	DNA repair; Nuclear receptor co-regulator	P51587	675	BRCA2	13q12.3	human	S3291	PHOSPHORYLATION	455462	SPICTFVsPAAQKAF		molecular association, regulation	cell cycle regulation; chromatin organization, altered	Rad51(DISRUPTS)		11983; 3301232; 5247	4	0	0		
EphA2	EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Protein kinase, TK; Protein kinase, tyrosine (receptor)	P29317	1969	EPHA2	1p36	human	S897	PHOSPHORYLATION	1244153	RVSIRLPsTSGSEGV		intracellular localization	carcinogenesis, induced; cell motility, altered			9987306	1	18	148	 high levels in grade IV astrocytomas (GBM samples);  required for leading edge localization and cell polarization; regulates cell migration and invasion	
AurC	EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor)	O88445	20871	Aurkc		mouse	T171	PHOSPHORYLATION	455456	TPSLRRKtMCGTLDY	Pkinase	enzymatic activity, inhibited				8291	2	5	64	complex effects on enzymatic activity: mutation of T171 or T175 to alanine increases kinase activity, while double mutant is inactive.	
KCNN4	Channel, potassium; Membrane protein, integral; Membrane protein, multi-pass	Q9QYW1	65206	Kcnn4		rat	S312	PHOSPHORYLATION	452143	YAKEMKEsAARLLQE	CaMBD	activity, inhibited				4074	1	0	0		
Daxx	Apoptosis; Nuclear receptor co-regulator; Transcription, coactivator/corepressor	O35613	13163	Daxx		mouse	S669	PHOSPHORYLATION	7249306	TSVQPMPsPPLASVA	Daxx	activity, induced				1826	1	1	1	Phosphorylation of S669 may downregulate Daxx-mediated transcriptional repression.	
ITGB4	Cell adhesion; Membrane protein, integral; Motility/polarity/chemotaxis; Receptor, misc.	P16144	3691	ITGB4	17q25	human	S1364	PHOSPHORYLATION	451655	PSGSQRPsVSDDTGC		molecular association, regulation	cell motility, altered; cytoskeletal reorganization	plectin 1(DISRUPTS)		12087; 15562502	4	1	2		
MDM2	EC 6.3.2.-; EC 6.3.2.19; Inhibitor protein; Ligase; UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase	Q00987	4193	MDM2	12q14.3-q15	human	S188	PHOSPHORYLATION	453413	RKRHKSDsISLSFDE		protein stabilization				4131	3	1	0		
IKKB	EC 2.7.11.10; KINASE; Kinase, protein; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor)	O88351	16150	Ikbkb		mouse	S689	PHOSPHORYLATION	3676802	SHPGQLMsQPSSACD		molecular association, regulation; phosphorylation		PPP2R3C(INDUCES)		17675011	1	0	1	interaction with PPP2R3C (aka G4-1) downregulates IKK-beta activity;  S181 phosphorylation increased in S679/682/689/692/697/701/705A mutant	
p53	Activator protein; DNA binding protein; Motility/polarity/chemotaxis; Nuclear receptor co-regulator; Transcription factor; Tumor suppressor	P04637	7157	TP53	17p13.1	human	K120	ACETYLATION	474514	FLHSGTAkSVTCTYS	DEC-1_N; P53		apoptosis, induced; transcription, altered			2790309; 7647800	18	1	0	 ; ZNF420 (Apak) represses p53 activity by attenuating its acetylation ;  p53 8KR mutant can be still degraded by Mdm2; p53 8KR mutation (K120/164/370/372/373/381/382/386R) impairs p53-dependent transcription	
TMOD1	Cell development/differentiation; Contractile protein; Cytoskeletal protein; Motility/polarity/chemotaxis	P28289	7111	TMOD1	9q22.3	human	T54	PHOSPHORYLATION	22561900	GLRQKDQtTKAPTGP	Tropomodulin		cytoskeletal reorganization			22561500	1	0	0	involved in TMOD1 function in actin capping	
SF3B1	RNA binding protein; RNA splicing; Spliceosome	O75533	23451	SF3B1	2q33.1	human	T313	PHOSPHORYLATION	449360	HGSGWAEtPRTDRGG	SF3b1	molecular association, regulation		NIPP-1(INDUCES)		5421	1	13	86		
axin 1	Adaptor/scaffold	O15169	8312	AXIN1	16p13.3	human	S75	PHOSPHORYLATION	4697306	LGYEPEGsASPTPPY			transcription, inhibited	GSK3B(INDUCES)		25785410	1	8	20		
PKCD	EC 2.7.10.2; EC 2.7.11.13; KINASE; Kinase, protein; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor)	Q05655	5580	PRKCD	3p21.31	human	S299	PHOSPHORYLATION	483986	NQVTQRAsRRSDSAS		intracellular localization				12017	1	6	23	localizes to the plasma and nuclear membrane	
ENaC-gamma	Channel, sodium; Membrane protein, integral; Membrane protein, multi-pass	P37091	24768	Scnn1g		rat	T623	PHOSPHORYLATION	451220	PGSTVPGtPPPRYNT		molecular association, regulation; activity, inhibited		NEDD4L(DISRUPTS)		7683; 3454	3	0	0		
VIPR1	GPCR, family 2; Membrane protein, integral; Membrane protein, multi-pass; Motility/polarity/chemotaxis; Receptor, GPCR	P32241	7433	VIPR1	3p22	human	S447	PHOSPHORYLATION	455662	VSPGARRsSSFQAEV		receptor desensitization, altered				5855	1	2	0		
FOXO1A	DNA binding protein; Nuclear receptor co-regulator; Transcription factor	Q12778	2308	FOXO1	13q14.1	human	S329	PHOSPHORYLATION	448076	STISGRLsPIMTEQD		intracellular localization	transcription, altered; transcription, inhibited			1094; 12525214; 3405	8	7	9	multiple site mutant (8A)	
CRY2	DNA binding protein; Lyase	Q9R194	12953	Cry2		mouse	S557	PHOSPHORYLATION	456803	ALSSGPAsPKRKLEA		protein degradation; intracellular localization; phosphorylation				6841; 13354714	3	7	1	stimulates phosphorylation of S553; required for the circadian time-keeping mechanism	
NFkB-p105	DNA binding protein; Transcription factor	P19838	4790	NFKB1	4q24	human	S907	PHOSPHORYLATION	451565	QAHSLPLsPASTRQQ		activity, induced; protein stabilization; protein processing				5662; 3704	2	9	119		
AMPKA2	Autophagy; EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, CAMK; Protein kinase, Ser/Thr (non-receptor)	NP_835279	108079	Prkaa2		mouse	T172	PHOSPHORYLATION	448026	SDGEFLRtSCGSPNY	Pkinase; YukC	intracellular localization; enzymatic activity, induced	transcription, altered			6877; 1173003	47	9	19		
eNOS	Amino Acid Metabolism - arginine and proline; EC 1.14.13.39; Oxidoreductase	P29474	4846	NOS3	7q36	human	S114	PHOSPHORYLATION	448638	RKLQGRPsPGPPAPE		intracellular localization; enzymatic activity, induced				14821614; 7309806	17	2	0		
C3aR	GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR	Q16581	719	C3AR1	12p13.31	human	S459	PHOSPHORYLATION	17548377	GILEAAFsEELTRST		receptor internalization, induced; receptor desensitization, induced; molecular association, regulation	transcription, inhibited	ARRB1(INDUCES)		27132477	1	1	0		
villin	Actin binding protein; Motility/polarity/chemotaxis	P09327	7429	VIL1	2q35	human	Y64	PHOSPHORYLATION	3176603	SLSYDIHyWIGQDSS	Gelsolin		cytoskeletal reorganization			8883	1	0	0		
eNOS	Amino Acid Metabolism - arginine and proline; EC 1.14.13.39; Oxidoreductase	P29474	4846	NOS3	7q36	human	Y657	PHOSPHORYLATION	2811400	FGLGSRAyPHFCAFA	Flavodoxin_1	enzymatic activity, inhibited				11424224; 2807228	2	1	0		
RBM8A	RNA binding protein; RNA splicing; Spliceosome; Translation	Q9Y5S9	9939	RBM8A	1q21.1	human	S166	PHOSPHORYLATION	456534	RRGGRRRsRSPDRRR		molecular association, regulation	RNA splicing, altered	NCBP1(DISRUPTS); UPF3B(DISRUPTS); THOC4(DISRUPTS); TAP(DISRUPTS); RPL22(DISRUPTS)		6721	1	4	3	Phosphorylation is required for release downstream factors.  Phosphorylation interferes with RBM8A's arginine methylation in vitro (by rat PRMT1) and in vivo.	
Rad17	Cell cycle regulation	O75943	5884	RAD17	5q13	human	S646	PHOSPHORYLATION	447755	ETWSLPLsQNSASEL		molecular association, regulation; phosphorylation	cell cycle regulation; cell growth, altered	RAD1(INDUCES); claspin(INDUCES)		6453; 818; 2480200	8	0	0	regulates genomic stability, phosphorylation of Chk1	
mAChR M2	GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR	P08172	1129	CHRM2	7q31-q35	human	S309	PHOSPHORYLATION	459107	TQDENTVsTSLGHSK	7tm_1	receptor desensitization, altered; receptor internalization, altered				7628	3	0	0	Mutation of 4 S/T to A eliminates receptor desensitization in response to carbachol treatment (as measured by isoproterenol-stimulated cAMP production after pretreatment with carbachol).; Mutation of S286 T287 S288 S290 to A caused a faster rate and a greater extent of receptor internalization after agonist stimulation (transients only, not observed in stables).  Mutation of all 8 sites prevented internalization (in both transients and stables).	
GCH1	Cofactor and Vitamin Metabolism - folate biosynthesis; EC 3.5.4.16; Hydrolase	P22288	29244	Gch1		rat	S130	PHOSPHORYLATION	10428814	VKDIDMFsMCEHHLV	MAPKK1_Int	enzymatic activity, induced				10353908	1	0	0		
Myf-5	DNA binding protein; Transcription factor	P13349	4617	MYF5	12q21	human	S49	PHOSPHORYLATION	457384	HKAELQGsDEDEHVR	Basic	activity, induced				7047	1	0	0		
PXN iso2	Adaptor/scaffold; Cell adhesion; Cytoskeletal protein; Motility/polarity/chemotaxis	P49023-2	5829	PXN	12q24.31	human	Y31	PHOSPHORYLATION	448785	FLSEETPySYPTGNH		activity, induced; protein degradation; molecular association, regulation; phosphorylation	cell cycle regulation; cell motility, altered; cytoskeletal reorganization; transcription, altered	Src(INDUCES); CrkL(INDUCES)		9180; 15022718; 3394329; 2051; 2466211; 6675; 11807	35	6	64	Paxillin phosphorylation induces ERK activation.; decreases RECK expression and increases GTP-Rac1 levels; essential for EGFR-mediated Erk1/2 activation and cell proliferation	
DNMT1	Amino Acid Metabolism - cysteine and methionine; Cell development/differentiation; EC 2.1.1.37; Methyltransferase; Methyltransferase, DNA; Transcription regulation	P26358	1786	DNMT1	19p13.2	human	S154	PHOSPHORYLATION	476108	AKPEPSPsPRITRKS		protein stabilization; enzymatic activity, induced				19046200	1	11	4	decreased stability in 154A mutant after treatment with 5'-Aza-2-Deoxycytidine	
TAL1	DNA binding protein; Transcription factor	P17542	6886	TAL1	1p32	human	T90	PHOSPHORYLATION	457536	EARHRVPtTELCRPP		protein degradation; molecular association, regulation; ubiquitination	translation, induced	CHIP(INDUCES)		7133; 7890604	2	0	10		
TPM1	Actin binding protein; Motility/polarity/chemotaxis; Motor protein	P09493	7168	TPM1	15q22.1	human	S283	PHOSPHORYLATION	451804	HALNDMTsI______	Tropomyosin; AAA_13; ERM; Reo_sigmaC; ATG16; SlyX		carcinogenesis, inhibited; cell motility, inhibited			27257034	8	10	83	decreases cancer cells migration through the endothelial barrier in response to H2O2	
P130Cas	Adaptor/scaffold; Motility/polarity/chemotaxis	Q63767	25414	Bcar1		rat	Y762	PHOSPHORYLATION	448399	EGGWMEDyDYVHLQG	DUF3513	molecular association, regulation; phosphorylation		Src(INDUCES); Lck(INDUCES); Fyn(INDUCES)		6973; 2636; 7708801	6	2	24		
NFAT1	DNA binding protein; Transcription factor	Q60591	18019	Nfatc2		mouse	S328	PHOSPHORYLATION	447853	PSKIWKTsPDPTPVS			transcription, inhibited			1188	0	9	0		
NFAT5	Transcription factor	O94916	10725	NFAT5	16q22.1	human	S158	PHOSPHORYLATION	2715403	LLDNSRMsCQDEGCG		intracellular localization				2704322	2	2	0		
MDM2	EC 6.3.2.-; EC 6.3.2.19; Inhibitor protein; Ligase; UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase	Q00987	4193	MDM2	12q14.3-q15	human	S269	PHOSPHORYLATION	455458	SEEGQELsDEDDEVY		molecular association, regulation	cell growth, altered	Rb(DISRUPTS)	RNA(DISRUPTS)	5206	3	1	0	decreases ability to bind poly-G RNA	
TBL1XR1	Nuclear receptor co-regulator; Transcription, coactivator/corepressor	Q9BZK7	79718	TBL1XR1	3q26.32	human	T203	PHOSPHORYLATION	2509602	WNLSENStSGSTQLV			transcription, induced			2425230	1	0	0		
AurA	EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor)	O14965	6790	AURKA	20q13	human	T288	PHOSPHORYLATION	448784	APSSRRTtLCGTLDY	Pkinase	enzymatic activity, induced	cell cycle regulation; cytoskeletal reorganization			6991; 15173401; 2365408; 11966; 4500; 28722427; 6839	26	4	7		
NFkB-p100	DNA binding protein; Transcription factor	Q00653	4791	NFKB2	10q24	human	S870	PHOSPHORYLATION	450167	KEDSAYGsQSVEQEA		molecular association, regulation; protein processing		IKKA(INDUCES)		4270; 2785	5	0	1		
KIF23	Microtubule binding protein; Motility/polarity/chemotaxis; Motor protein	E9Q5G3	71819	Kif23		mouse	S807	PHOSPHORYLATION	470674	VRHRRSRsAGSRWVD		intracellular localization	cell cycle regulation; cytoskeletal reorganization			8646	3	4	0	regulates cytokinesis	
ASBT	Membrane protein, integral; Membrane protein, multi-pass; Transporter	Q62633	29500	Slc10a2		rat	T339	PHOSPHORYLATION	453446	PMPSFQEtNKGFQPD		protein degradation				4152	1	0	0		
DAB1 iso2	Adaptor/scaffold	P97318-2	13131	Dab1		mouse	T484	PHOSPHORYLATION	479421	PSTNSPPtPAPRQSS		phosphorylation				11449	1	0	0	inhibits tyrosine phosphorylation	
Kv1.4	Channel, potassium; Membrane protein, integral; Membrane protein, multi-pass	P22459	3739	KCNA4	11p14	human	T601	PHOSPHORYLATION	456509	LKKFRSStSSSLGDK		protein degradation				6706	1	0	0	phosphorylation of site induces endocytosis of the Kv1.4 channel.	
ATP1A1	EC 3.6.3.9; Hydrolase; Membrane protein, integral; Membrane protein, multi-pass	P06685	24211	Atp1a1		rat	Y542	PHOSPHORYLATION	458467	KDAFQNAyLELGGLG	Hydrolase	enzymatic activity, induced	exocytosis, altered	AP-2 alpha(DISRUPTS)		8663	1	5	130		
HMGA1	DNA binding protein	P17096	3159	HMGA1	6p21	human	S36	PHOSPHORYLATION	455950	PRKQPPVsPGTALVG		molecular association, regulation			DNA(INDUCES)	970060	3	21	14	Cdc2 phosphorylated HMGA1 has lower binding affinity than  HIPK2 phosphorylated HMGA1. 	
MEK2	EC 2.7.12.2; KINASE; Kinase, protein; Protein kinase, STE; Protein kinase, dual-specificity	P36507	5605	MAP2K2	19p13.3	human	S222	PHOSPHORYLATION	448073	VSGQLIDsMANSFVG	Pkinase	enzymatic activity, induced				5930044	42	5	54		
ULK1	Autophagy; EC 2.7.1.37; EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor)	O70405	22241	Ulk1		mouse	S555	PHOSPHORYLATION	3176155	GLGCRLHsAPNLSDF			autophagy, altered			17740400	4	14	20		
OTUB1	EC 3.1.2.-; EC 3.4.-.-; EC 3.4.19.12; Protease; Ubiquitin conjugating system; Ubiquitin-specific protease	Q96FW1	55611	OTUB1	11q13.1	human	S18	PHOSPHORYLATION	3072783	QEPLGSDsEGVNCLA		molecular association, regulation		YpkA(INDUCES)		14790313	1	4	0	regulates bacterial uptake 	
USP8	EC 3.1.2.15; EC 3.4.19.12; Protease; Ubiquitin conjugating system; Ubiquitin-specific protease	Q80U87	84092	Usp8		mouse	T907	PHOSPHORYLATION	475072	TCRRRSRtFEAFMYL	UCH	enzymatic activity, induced	cell growth, altered			9282	1	0	0	increases de-ubiquitation activity towards E3-ligase Nrdp1 and the ErbB3 receptor	
ZFYVE28	Cytoskeletal protein; Lipid binding protein	Q9HCC9	57732	ZFYVE28	4p16.3	human	K87	UBIQUITINATION	7250588	APRDFCVkFPEEIRH		ubiquitination				12482419	1	3	124		
TNNI3	Actin binding protein; Motility/polarity/chemotaxis; Motor protein	P19429	7137	TNNI3	19q13.4	human	S150	PHOSPHORYLATION	451822	TLRRVRIsADAMMQA	Troponin		cytoskeletal reorganization; signaling pathway regulation			25227630	5	2	0	increases myofilament Ca2+-sensitive force development and blunts TNNI PKA dependent desensitization	
PIK3R1	Enzyme, regulatory subunit; KINASE; Kinase, lipid; Motility/polarity/chemotaxis	P27986	5295	PIK3R1	5q13.1	human	Y528	PHOSPHORYLATION	457097	IQRIMHNyDKLKSRI	IncA; DUF1338	molecular association, regulation; enzymatic activity, induced	cell motility, altered	SHP-2(INDUCES); IRS1(INDUCES)		7747	1	2	6		
PKCD	EC 2.7.10.2; EC 2.7.11.13; KINASE; Kinase, protein; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor)	P09215	170538	Prkcd		rat	T505	PHOSPHORYLATION	447511	FGENRAStFCGTPDY	Pkinase	enzymatic activity, induced				4313625; 7390	38	17	104		
TIEG2	C2H2-type zinc finger protein; DNA binding protein; Transcription factor	O14901	8462	KLF11	2p25	human	S166	PHOSPHORYLATION	456011	GLEPVPSsPCRAKGT		molecular association, regulation		SIN3A(DISRUPTS)		6578	1	0	0		
ELK1	DNA binding protein; Transcription factor	A4GTP4	314436	Elk1		rat	T160	PHOSPHORYLATION	2028401	MRSGLYStFTIQSLQ		activity, inhibited	transcription, inhibited	SRF(DISRUPTS)		1968312	1	0	0		
CAD	Amino Acid Metabolism - alanine, aspartate and glutamate; EC 2.1.3.2; EC 3.5.2.3; EC 6.3.5.5; Hydrolase; KINASE; Ligase; Nucleotide Metabolism - pyrimidine; Transferase	P27708	790	CAD	2p22-p21	human	S1406	PHOSPHORYLATION	451249	GAGGRRLsSFVTKGY	MGS	phosphorylation				9291	3	16	3	inhibits phosphorylation of T456	
EGR1	C2H2-type zinc finger protein; DNA binding protein; Transcription factor	P18146	1958	EGR1	5q31.1	human	S196	PHOSPHORYLATION	11423701	PLSCAVPsNDSSPIY	DUF3446		transcription, altered		DNA(DISRUPTS)	10274604	1	0	0		
desmin	Cytoskeletal protein; Motility/polarity/chemotaxis	P31001	13346	Des		mouse	S7	PHOSPHORYLATION	466342	_MSQAYSsSQRVSSY			transcription, altered; cell growth, altered			9579	2	0	0	important for cardiomyogenesis	
ROS	EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Protein kinase, TK; Protein kinase, tyrosine (receptor)	P08922	6098	ROS1	6q22	human	Y2274	PHOSPHORYLATION	454391	KNREGLNyMVLATEC		molecular association, regulation		SHP-1(INDUCES)		4262	1	2	10	Mutation of Y2274 abolished ligand-dependent association of ROS with SHP-1.	
CEACAM1	Cell adhesion; Immunoglobulin superfamily; Membrane protein, integral; Motility/polarity/chemotaxis	P13688	634	CEACAM1	19q13.2	human	T492	PHOSPHORYLATION	473038	PNKMNEVtYSTLNFE	DUF2668		apoptosis, altered; cytoskeletal reorganization			9160	1	0	0	plays a role in cell polarization and lumen formation	
FOXO4	DNA binding protein; Transcription factor	P98177	4303	FOXO4	Xq13.1	human	T451	PHOSPHORYLATION	448518	PIPKALGtPVLTPPT		intracellular localization	cell cycle regulation; transcription, induced			4299; 911	3	2	0		
FosB	DNA binding protein; Transcription factor	P53539	2354	FOSB	19q13.32	human	S27	PHOSPHORYLATION	465535	SAESQYLsSVDSFGS		activity, induced; protein stabilization	transcription, induced			7983; 9263	4	0	0		
ARHGAP12	GTPase activating protein, Rac/Rho	Q8C0D4	75415	Arhgap12		mouse	T228	PHOSPHORYLATION	2424903	STEQMRAtTPPNQGR			cell cycle regulation; cell motility, altered			2790302	0	13	21		
Kv4.2	Channel, potassium; Membrane protein, integral; Membrane protein, multi-pass	Q63881		Kcnd2		rat	S537	PHOSPHORYLATION	4668100	CSRRHKKsFRIPNAN	DUF3399	intracellular localization; phosphorylation				4641423	1	0	1	increases phosphorylation at T602 and T607 by ERK	
NGFR	Membrane protein, integral; Receptor, misc.	P08138	4804	NGFR	17q21-q22	human	S303	PHOSPHORYLATION	10432300	PEGEKLHsDSGISVD		intracellular localization	cytoskeletal reorganization; cell growth, altered			10144224	1	0	0	 inactivation of Rho ; translocation to lipid rafts	
BMAL1	DNA binding protein; Transcription factor	O00327	406	ARNTL	11p15	human	S17	PHOSPHORYLATION	12575203	STISDFMsPGPTDLL		protein degradation	transcription, altered			12525210	1	0	0	stabilization of BMAL1 protein leads to reduction in its transcription activation ability	
Ikaros	C2H2-type zinc finger protein; DNA binding protein; Transcription factor	Q03267	22778	Ikzf1		mouse	T393	PHOSPHORYLATION	451353	SNSCQDStDTESNAE		activity, inhibited	cell cycle regulation		DNA(DISRUPTS)	3559	1	0	8		
GR	DNA binding protein; Mitochondrial; Nuclear receptor; Transcription factor	P04150	2908	NR3C1	5q31.3	human	S226	PHOSPHORYLATION	451796	IDENCLLsPLAGEDD	GCR	molecular association, regulation; intracellular localization; activity, inhibited	transcription, induced; transcription, inhibited	GRIP1(INDUCES)		12080; 13159409; 8536	23	4	1		
EpoR	EC 2.7.10.2; Membrane protein, integral; Receptor, cytokine	P14753	13857	Epor		mouse	Y453	PHOSPHORYLATION	455531	PTPPHLKyLYLVVSD		molecular association, regulation; receptor internalization, altered		PIK3R2(INDUCES); PIK3R1(INDUCES)		7454300	5	0	0	required for optimal PIK3R1/2 binding 	
IRS2	Adaptor/scaffold; Motility/polarity/chemotaxis	P81122	384783	Irs2		mouse	Y624	PHOSPHORYLATION	3597307	PKVAYNPyPEDYGDI		molecular association, regulation		InsR(DISRUPTS)		9082	1	1	1		
EWS	RNA binding protein; Transcription, coactivator/corepressor	Q01844	2130	EWSR1	22q12.2	human	S266	PHOSPHORYLATION	448028	SSYGQQSsFRQDHPS		intracellular localization	transcription, induced			1671	2	0	0		
MEF2C	DNA binding protein; Transcription factor	Q8CFN5	17260	Mef2c		mouse	S110	PHOSPHORYLATION	4758829	ADDSVGHsPESEDKY	HJURP_C	molecular association, regulation		Pin1(INDUCES)		15235218	1	5	2	Pin1 binding decreases MEF2C stability and its transcriptional activity	
ASK1	EC 2.7.11.25; KINASE; Kinase, protein; Protein kinase, STE; Protein kinase, Ser/Thr (non-receptor)	Q99683	4217	MAP3K5	6q22.33	human	Y718	PHOSPHORYLATION	458209	IPERDSRySQPLHEE	Pkinase	protein degradation; molecular association, regulation		SOCS1(INDUCES)		7613734	1	0	0	SHP2 dephosphorylation of ASK1 Y798 disrupts binding of ASK1 to SOCS1 and induces apoptosis.	
CTNND1	Actin binding protein; Adaptor/scaffold; Cell adhesion; G protein regulator, misc.; Motility/polarity/chemotaxis	P30999	12388	Ctnnd1		mouse	K625	ACETYLATION	17391700	CFGAKKGkDEWFSRG			cytoskeletal reorganization			8130	0	1	0		
WEE1B	EC 2.7.10.2; KINASE; Kinase, protein; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor)	Q4U4S4	381759	Wee2		mouse	S15	PHOSPHORYLATION	456697	QGLNKKLsFSFCEED		enzymatic activity, induced	cell cycle regulation			27902357	3	0	0		
EGFR	EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Protein kinase, TK; Protein kinase, tyrosine (receptor)	P00533	1956	EGFR	7p12	human	Y1197	PHOSPHORYLATION	448060	STAENAEyLRVAPQS		activity, induced; protein degradation; molecular association, regulation; intracellular localization; receptor internalization, altered; phosphorylation; enzymatic activity, induced	cell growth, altered	Cbl(INDUCES); RASA1(INDUCES); EGFR(INDUCES); CIN85(INDUCES); SHP-1(INDUCES)		2641; 2651; 2311; 4843012; 5203; 6513; 2310; 2852610; 1064; 2309; 2506303	70	32	984	Stimulation with EGF or PDGF SH3SKP1 induced minimal increase in association. Association is constitutive in tumor cell lines.	
CREB	DNA binding protein; Transcription factor	P15337	81646	Creb1		rat	S121	PHOSPHORYLATION	451811	SVDSVTDsQKRREIL	pKID	protein degradation				8156	10	0	0	required for PDGF-induced protein ubiquitination	
EphB1	EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Protein kinase, TK; Protein kinase, tyrosine (receptor)	P09759	24338	Ephb1		rat	Y594	PHOSPHORYLATION	449995	GSPGMKIyIDPFTYE		molecular association, regulation		Nck1(INDUCES)		27257053	4	13	115		
SNCA	Adaptor/scaffold	P37840	6622	SNCA	4q21	human	S129	PHOSPHORYLATION	448278	NEAYEMPsEEGYQDY	Synuclein	activity, induced; molecular association, regulation; intracellular localization; protein conformation	apoptosis, altered; apoptosis, induced	SNCA(DISRUPTS); SNCAIP(INDUCES); PARK2(INDUCES); SNCA(INDUCES)		25255505; 4282203; 3548312; 3391005; 22518513; 6818; 4215310	31	4	0	promotes aggregates	
MgcRacGAP	GTPase activating protein, Rac/Rho	Q9H0H5	29127	RACGAP1	12q13.12	human	S157	PHOSPHORYLATION	3211992	GSILSDIsFDKTDES	CALCOCO1; Cep57_CLD	molecular association, regulation	cell cycle regulation	ECT2(INDUCES)		7543516	1	6	0		
G-alpha(q)	G protein; G protein, heterotrimeric; G protein, heterotrimeric alpha G(q)	P50148	2776	GNAQ	9q21	human	S53	PHOSPHORYLATION	482964	GTGESGKsTFIKQMR	G-alpha	enzymatic activity, inhibited				11772	1	1	0	inhibits G-alpha(q) signaling following infection of bacteria Yersinia pseudotuberculosis	
IKKE	EC 2.7.11.10; Inhibitor protein; KINASE; Kinase, protein; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor)	Q9R0T8	56489	Ikbke		mouse	S172	PHOSPHORYLATION	447631	DDDEKFVsVYGTEEY	Pkinase	enzymatic activity, induced				4046	3	1	0		
N-Myc	DNA binding protein; Transcription factor	P04198	4613	MYCN	2p24.3	human	S62	PHOSPHORYLATION	448222	LLPTPPLsPSRGFAE	Myc_N	molecular association, regulation; ubiquitination		AurA(INDUCES)		7550801	1	10	12		
Gab1	Adaptor/scaffold; Motility/polarity/chemotaxis	Q13480	2549	GAB1	4q31.21	human	Y259	PHOSPHORYLATION	448877	ASVDSSLyNLPRSYS		molecular association, regulation		CDK6(INDUCES)		11387287	1	19	462	promotes HGF-induced DNA synthesis	
PLCG1	Carbohydrate Metabolism - inositol phosphate; EC 3.1.4.11; Motility/polarity/chemotaxis; Phospholipase	Q62077	18803	Plcg1		mouse	Y783	PHOSPHORYLATION	447667	EGRNPGFyVEANPMP		molecular association, regulation	cell adhesion, altered	PLCG1(INDUCES)		12023001; 4606; 6283	59	25	542		
CRMP-2	Microtubule binding protein; Motility/polarity/chemotaxis	P47942	25416	Dpysl2		rat	T514	PHOSPHORYLATION	454386	SVTPKTVtPASSAKT		molecular association, regulation; activity, inhibited	cytoskeletal reorganization	TUBA1B(DISRUPTS)		4436	17	14	36		
IRF5	DNA binding protein; Transcription factor	Q13568	3663	IRF5	7q32	human	S158	PHOSPHORYLATION	27101102	QRMLPSLsLTEDVKW		intracellular localization	apoptosis, induced			25785429	1	1	0	nuclear localization- S158 requires an activator, while S435 and S446 do not. 	
myelin P0	Adaptor/scaffold; Membrane protein, integral	P06907	24564	Mpz		rat	S228	PHOSPHORYLATION	458932	AMLDHSRsTKAASEK	Protocadherin; IncA; Myelin-PO_C		cell adhesion, altered			11789	2	1	0		
MEKK3	EC 2.7.11.25; KINASE; Kinase, protein; Protein kinase, STE; Protein kinase, Ser/Thr (non-receptor)	Q61084	26406	Map3k3		mouse	S337	PHOSPHORYLATION	468184	DPRGRLRsADSENAL		enzymatic activity, inhibited				8638	1	13	45		
STAT5A	DNA binding protein; Motility/polarity/chemotaxis; Transcription factor	P42230	20850	Stat5a		mouse	S128	PHOSPHORYLATION	456899	REANNCSsPAGVLVD		phosphorylation	transcription, induced		DNA(INDUCES)	6895	1	1	0	Phosphorylation of S127 or S128 is required for transcription.  Phosphorylation of S127/S128 required for phosphorylation on Y694 and binding of DNA.	
NHE1	Membrane protein, integral; Membrane protein, multi-pass; Motility/polarity/chemotaxis; Transporter	P19634	6548	SLC9A1	1p36.1-p35	human	S770	PHOSPHORYLATION	475073	MMRSKETsSPGTDDV		activity, induced; protein stabilization; protein conformation				9266; 27935600	5	2	0	phosphomimetic mutant was strongly stabilized and resulted in a more compact region which affects NHE1 activity.	
ERM	DNA binding protein; Transcription factor	P41161	2119	ETV5	3q28	human	S367	PHOSPHORYLATION	451201	PPYQRRGsLQLWQFL	Ets	protein conformation	transcription, induced			3426	1	0	0		
EpoR	EC 2.7.10.2; Membrane protein, integral; Receptor, cytokine	P14753	13857	Epor		mouse	Y455	PHOSPHORYLATION	455532	PPHLKYLyLVVSDSG		molecular association, regulation; receptor internalization, altered		PIK3R2(INDUCES); PIK3R1(INDUCES)		7454300	6	0	0	required for optimal PIK3R1/2 binding 	
GABRB3	Channel, chloride; Channel, ligand-gated; Membrane protein, integral; Membrane protein, multi-pass	P15433	14402	Gabrb3		mouse	S433	PHOSPHORYLATION	450246	THLRRRSsQLKIKIP	Neur_chan_memb	molecular association, regulation; receptor desensitization, altered		AP-2 alpha(DISRUPTS)		1968324; 2951	9	0	3		
p53	Activator protein; DNA binding protein; Motility/polarity/chemotaxis; Nuclear receptor co-regulator; Transcription factor; Tumor suppressor	P04637	7157	TP53	17p13.1	human	K382	DI-METHYLATION	4219800	QSTSRHKkLMFKTEG		protein stabilization; molecular association, regulation		53BP1(INDUCES)		4219000	1	1	0	53BP1 recognition of dimethylated K382 plays a role in regulating p53 protein accumulation in response to DNA damage	
SHP-2	EC 3.1.3.48; Motility/polarity/chemotaxis; PHOSPHATASE; Protein phosphatase, tyrosine (non-receptor)	Q06124	5781	PTPN11	12q24	human	Y584	PHOSPHORYLATION	448493	REDSARVyENVGLMQ		molecular association, regulation; phosphorylation; enzymatic activity, induced	cell motility, altered	SHP-2(INDUCES); Fyn(INDUCES); Grb2(INDUCES)		6156; 17613013; 1361	13	38	1132	contributes to Y546 phosphorylation; Individual mutation of either site reduced SHP-2 activity. Mutation of Y546 and Y584 deceased tumor cell invasion.	
SLC5A5	Membrane protein, integral; Membrane protein, multi-pass; Transporter	Q63008	114613	Slc5a5		rat	T49	PHOSPHORYLATION	990310	RSADDFFtGGRQLAA	SSF	protein conformation				970026	1	1	0		
GluR1	Channel, calcium; Channel, ligand-gated; Membrane protein, integral; Membrane protein, multi-pass	P19490	50592	Gria1		rat	S863	PHOSPHORYLATION	448566	TSTLPRNsGAGASGG		activity, induced; receptor internalization, altered; intracellular localization		GluR2(INDUCES)		4904516; 1172201; 7307; 4402; 1988; 4910505; 1702	64	0	0		
KCNJ8	Channel, potassium; Membrane protein, integral; Membrane protein, multi-pass	Q63664	25472	Kcnj8		rat	S379	PHOSPHORYLATION	1458601	SELSHQNsLRKRNSM	IRK	activity, inhibited				1172871	1	2	0		
ANPB	EC 4.6.1.2; Guanylyl cyclase; KINASE; Kinase, protein; Lyase; Membrane protein, integral; Nucleotide Metabolism - purine; Protein kinase, RGC; Protein kinase, dual-specificity; Receptor, misc.	P16067	116564	Npr2		rat	T529	PHOSPHORYLATION	17557700	SSYGSLMtAHGKYQI	Pkinase_Tyr	enzymatic activity, induced				17482904	1	1	0		
p47phox	EC 1.-.-.-; Oxidoreductase	P14598	653361	NCF1	7q11.23	human	S379	PHOSPHORYLATION	451498	DLILNRCsESTKRKL	p47_phox_C	molecular association, regulation; intracellular localization		CYBA(INDUCES); p67phox(DISRUPTS); p40phox(DISRUPTS)		3677; 7292; 8704; 4407	6	0	0		
WNK1	EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor)	Q9JIH7	116477	Wnk1		rat	S378	PHOSPHORYLATION	456474	LATLKRAsFAKSVIG	Pkinase	enzymatic activity, induced				4211	2	4	0		
Kv7.2	Channel, potassium; Membrane protein, integral; Membrane protein, multi-pass	O88943	170848	Kcnq2		rat	S534	PHOSPHORYLATION	11082900	CVMRFLVsKRKFKES	KCNQ_channel	activity, induced				10296903	1	0	0	Mutants showed reduced currents induced by acetylcholine.	
CTNNB1	Actin binding protein; Cell adhesion; Motility/polarity/chemotaxis; Nuclear receptor co-regulator; Transcription factor	Q02248	12387	Ctnnb1		mouse	S33	PHOSPHORYLATION	447487	QQQSYLDsGIHSGAT		activity, induced; protein degradation; ubiquitination	transcription, altered			4969204; 5730	51	3	2		
HSF1	DNA binding protein; Transcription factor	P38532	15499	Hsf1		mouse	S415	PHOSPHORYLATION	455264	SALLDLFsPSVTMPD	Vert_HS_TF	intracellular localization				4405	2	1	0		
geminin	Cell cycle regulation; Motility/polarity/chemotaxis	O75496	51053	GMNN	6p22.3	human	S184	PHOSPHORYLATION	25535401	EEETVEDsLVEDSEI	Geminin; Fmp27_WPPW; APG6	molecular association, regulation		HOXC9(INDUCES)		25347043	1	1	0		
PGM1	Carbohydrate Metabolism - amino sugar and nucleotide sugar; Carbohydrate Metabolism - galactose; Carbohydrate Metabolism - glycolysis and gluconeogenesis; Carbohydrate Metabolism - pentose phosphate pathway; Carbohydrate Metabolism - starch and sucrose; EC 5.4.2.2; Isomerase	P36871	5236	PGM1	1p31	human	T467	PHOSPHORYLATION	454029	SANDKVYtVEKADNF	PGM_PMM_IV	enzymatic activity, induced				4177	1	0	0		
ANKRD3	EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, Ser/Thr (non-receptor); Protein kinase, TKL	Q9ERK0	72388	Ripk4		mouse	T184	PHOSPHORYLATION	2926100	SMDGLFGtIAYLPPE	Pkinase	enzymatic activity, induced	transcription, altered			8747	1	0	0	WT ANKRD3 and even mutant T184A can activate NFkB. 	
CACNA1E	Channel, calcium; Membrane protein, integral; Membrane protein, multi-pass	Q07652	54234	Cacna1e		rat	T365	PHOSPHORYLATION	455592	LEVLRRAtIKRSRTE		activity, induced				5534	1	0	9	potentiation of Ca(2+) currents	
p53	Activator protein; DNA binding protein; Motility/polarity/chemotaxis; Nuclear receptor co-regulator; Transcription factor; Tumor suppressor	P02340	22059	Tp53		mouse	S15	PHOSPHORYLATION	447490	ISLELPLsQETFSGL	P53_TAD	activity, induced; molecular association, regulation; protein stabilization; intracellular localization	cell cycle regulation; apoptosis, altered; carcinogenesis, inhibited; apoptosis, induced; apoptosis, inhibited; transcription, induced; transcription, altered; cell growth, altered	14-3-3 beta(INDUCES); STRAP(INDUCES); p21Cip1(INDUCES); NME1(INDUCES)		6877; 3475708; 5611; 25324600; 6425; 4313622; 5249; 5636; 1910502; 5011208; 5004502; 5623; 13789004; 4792; 5004503; 6115922; 5011205; 6947; 5639; 17630405; 7932	347	2	0	Overexpression of MELK induced increased expression of p53, p21, MDM2, and BAX. p53 nuclear translocation	
PHB	Apoptosis; Cell cycle regulation; Chaperone; Mitochondrial; Motility/polarity/chemotaxis; Transcription, coactivator/corepressor	P35232	5245	PHB	17q21	human	S121	O-GlcNAc	6374003	YDERVLPsITTEILK	Band_7	phosphorylation				6331325	1	0	0		
ROMK	Channel, potassium; Membrane protein, integral; Membrane protein, multi-pass	O88335	56379	Kcnj1		mouse	S25	PHOSPHORYLATION	449605	RQRARLVsKDGRCNI	IRK	activity, induced; intracellular localization				2247	8	0	0		
NBS1	Cell cycle regulation; DNA repair	O60934	4683	NBN	8q21	human	S343	PHOSPHORYLATION	448605	TTPGPSLsQGVSVDE		activity, induced; acetylation; phosphorylation	cell cycle regulation; apoptosis, induced; chromatin organization, altered; cell growth, altered			8674; 1163001; 3342625; 8673; 7120; 3886805; 3335906; 722	39	8	47	important for apoptosis induction; Increase XIAP expression, enhances cytoxicity	
PITPNM1	Cell surface	O00562	9600	PITPNM1	11q13	human	T794	PHOSPHORYLATION	451456	LEMLVPStPTSTSGA	DDHD	molecular association, regulation		PLK1(INDUCES)		3652	1	1	0		
CDH2	Cell adhesion; Membrane protein, integral; Motility/polarity/chemotaxis	P15116	12558	Cdh2		mouse	Y852	PHOSPHORYLATION	450692	NDPTAPPyDSLLVFD	Cadherin_C	molecular association, regulation		Shc1(INDUCES)		3133	2	0	0		
Fos	DNA binding protein; Motility/polarity/chemotaxis; Transcription factor	P12841	314322	Fos		rat	S362	PHOSPHORYLATION	448481	AAAHRKGsSSNEPSS		protein stabilization; protein conformation; phosphorylation	cell cycle regulation; transcription, altered			1023; 2626208; 1021; 8510	10	2	1		
PTEN	Carbohydrate Metabolism - inositol phosphate; EC 3.1.3.16; EC 3.1.3.48; EC 3.1.3.67; Motility/polarity/chemotaxis; Nuclear receptor co-regulator; PHOSPHATASE; Phosphatase, lipid; Tumor suppressor	O08586	19211	Pten		mouse	S380	PHOSPHORYLATION	448313	EPDHYRYsDTTDSDP		intracellular localization	cell cycle regulation			4248204	22	0	0		
NF1 iso2	GTPase activating protein, Ras; Motility/polarity/chemotaxis; Tumor suppressor	P21359-2	4763	NF1	17q11.2	human	S2813	PHOSPHORYLATION	456018	AGSFKRNsIKKIV__		molecular association, regulation; activity, inhibited		14-3-3 beta(INDUCES)		6580	1	1	12		
GR	DNA binding protein; Mitochondrial; Nuclear receptor; Transcription factor	P04150	2908	NR3C1	5q31.3	human	S203	PHOSPHORYLATION	447967	DLEFSSGsPGKETNE	GCR	molecular association, regulation; activity, inhibited	transcription, induced; transcription, inhibited	GRIP1(INDUCES)		12080; 13159409	13	2	0		
Arg	EC 2.7.10.2; KINASE; Kinase, protein; Protein kinase, TK; Protein kinase, tyrosine (non-receptor)	Q4JIM5	11352	Abl2		mouse	Y439	PHOSPHORYLATION	447923	RLMTGDTyTAHAGAK	Pkinase_Tyr	enzymatic activity, induced				12482266	3	24	1680		
ITGB4 iso2	Cell adhesion; Membrane protein, integral; Motility/polarity/chemotaxis; Receptor, misc.	P16144-2	3691	ITGB4	17q25	human	Y1526	PHOSPHORYLATION	450142	DLLPNHSyVFRVRAQ	fn3	molecular association, regulation	cell adhesion, altered	Shc1(INDUCES)		2765	1	1	5		
caldesmon	Actin binding protein	NP_776683	281660	CALD1		cow	S531	PHOSPHORYLATION	448466	QSVDKVTsPTKV___			cytoskeletal reorganization			4289	15	9	0		
Lmr1	EC 2.7.11.1; KINASE; Kinase, protein; Membrane protein, integral; Protein kinase, TK; Protein kinase, tyrosine (receptor)	Q80YE4	11302	Aatk		mouse	S528	PHOSPHORYLATION	456513	VPVLSAHsPSVGSEY			apoptosis, induced			6694	1	0	0		
SERCA2	Cell adhesion; EC 3.6.3.8; Endoplasmic reticulum; Hydrolase; Membrane protein, integral; Membrane protein, multi-pass; Transporter	P11507	29693	Atp2a2		rat	S38	PHOSPHORYLATION	448740	KLKERWGsNELPAEE	Cation_ATPase_N	activity, induced				2026	1	4	0	Phosphorylation by CaM kinase increased the Vmax for Ca++ transport.	
axin 1	Adaptor/scaffold	O15169	8312	AXIN1	16p13.3	human	S217	PHOSPHORYLATION	3174923	YTRTGSEsPKVCSDQ			transcription, inhibited	GSK3B(INDUCES)		25785410	1	3	0		
TSC2	Cell cycle regulation; GTPase activating protein, misc.; Nuclear receptor co-regulator; Tumor suppressor	P49816	24855	Tsc2		rat	S1377	PHOSPHORYLATION	469993	ARPTVDLsFQPSQPL		activity, inhibited; phosphorylation	translation, altered; apoptosis, inhibited			8973	1	0	8	inhibits mTOR signaling.  required for Wnt-3a to stimulation phosphorylation of S6K and 4EBP1 and increase protein levels of cyclin D1 and VEGF (cyclin D1 through translation not transcription).	
C/EBP-alpha	DNA binding protein; Transcription factor	P05554	24252	Cebpa		rat	T222	PHOSPHORYLATION	449824	HLQPGHPtPPPTPVP		activity, inhibited	transcription, altered			7862	6	0	0	In 3T3L1 preadipocytes, mutation of T222/T226 to alanines increased transcription at CBE-containing promoter (as compared to WT C/EBP-alpha).  S230A had a similar effect as the double T->A mutation.  The triple alanine mutation had the highest transcription of the reporter gene.  S230A did not reduce T222/226 phosphorylation (although CHIR99021 inhibitor did).	
ERK5	EC 2.7.11.24; KINASE; Kinase, protein; Protein kinase, CMGC; Protein kinase, Ser/Thr (non-receptor)	Q13164	5598	MAPK7	17p11.2	human	S731	PHOSPHORYLATION	455519	DPLPPVFsGTPKGSG		intracellular localization; enzymatic activity, inhibited	transcription, altered			19084403	3	5	0		
ECT2	Guanine nucleotide exchange factor, Rac/Rho; Motility/polarity/chemotaxis	Q9H8V3	1894	ECT2	3q26.1-q26.2	human	T373	PHOSPHORYLATION	456870	VSMLSLNtPNSNRKR		activity, induced; protein conformation				6844	3	8	4		
ARHGAP12	GTPase activating protein, Rac/Rho	Q8C0D4	75415	Arhgap12		mouse	Y241	PHOSPHORYLATION	451932	GRPDSPVyANLQELK			cell cycle regulation; cell motility, altered			2790302	0	18	717		
PCNT	Cell cycle regulation	O95613	5116	PCNT	21q22.3	human	S1241	PHOSPHORYLATION	25617501	ISSHMREsFLMSPES			cytoskeletal reorganization			25617200	1	0	0	important for spindle formation and centrosomal microtubule nucleation and the recruitment of the PCM proteins for centrosome maturation in mitosis	
F3	Cell surface; Membrane protein, integral	P13726	2152	F3	1p22-p21	human	S295	PHOSPHORYLATION	3540201	ENSPLNVs_______			cell motility, altered			4427	1	0	0		
Snail1	C2H2-type zinc finger protein; Transcription factor	O95863	6615	SNAI1	20q13.2	human	S104	PHOSPHORYLATION	455881	GKGSQPPsPPSPAPS	CAP_N	activity, induced; protein degradation; ubiquitination	transcription, altered			11419352; 6376; 15031342	4	0	0		
MED28	Transcription factor	Q9H204	80306	MED28	4p16	human	Y64	PHOSPHORYLATION	466940	ASLVSQDyVNGTDQE		molecular association, regulation		Grb2(INDUCES)		8180	1	0	0		
CRY2	DNA binding protein; Lyase	Q9R194	12953	Cry2		mouse	S553	PHOSPHORYLATION	456804	TGPRALSsGPASPKR		protein degradation				6841; 13354714	2	1	0	required for the circadian time-keeping mechanism	
WASP	Adaptor/scaffold; Motility/polarity/chemotaxis	P42768	7454	WAS	Xp11.4-p11.21	human	S483	PHOSPHORYLATION	449294	KRSRAIHsSDEGEDQ		molecular association, regulation	cytoskeletal reorganization	ARPC3(INDUCES)		2167	2	8	0	The double mutant (S483A/S484A) was used in this study.	
IRS1	Adaptor/scaffold; Motility/polarity/chemotaxis	P35570	25467	Irs1		rat	S632	PHOSPHORYLATION	447506	NGDYMPMsPKSVSAP		molecular association, regulation		PIK3R1(DISRUPTS)		1903000	32	12	1		
PHKB	KINASE; Protein kinase, regulatory subunit	P12798	100009137	PHKB		rabbit	S12	PHOSPHORYLATION	470137	TGLMAEVsWKVLERR		molecular association, regulation; enzymatic activity, inhibited		PHKG1(INDUCES)		9028	1	0	0		
IRS1	Adaptor/scaffold; Motility/polarity/chemotaxis	P35568	3667	IRS1	2q36	human	S794	PHOSPHORYLATION	447557	QHLRLSTsSGRLLYA		molecular association, regulation	apoptosis, induced; cell growth, altered	PIK3C2A(DISRUPTS)		1173012	8	0	0		
FOXC2	Apoptosis; Cell development/differentiation; DNA binding protein; Transcription factor	Q99958	2303	FOXC2	16q24.1	human	S367	PHOSPHORYLATION	28129600	DHPSGPTsPLSALNL		molecular association, regulation	transcription, altered		DNA(INDUCES)	28129300	1	1	0	implicated in vascular remodeling  in vivo	
lamin A/C	Cytoskeletal protein	P02545	4000	LMNA	1q22	human	S404	PHOSPHORYLATION	478681	RSRGRASsHSSQTQG	DUF3584	intracellular localization				7523	3	19	97	nuclear transport of lamin	
Rb-like 2	Transcription, coactivator/corepressor	Q08999	5934	RBL2	16q12.2	human	T1097	PHOSPHORYLATION	449742	SMIRTGEtPTKKRGI		molecular association, regulation; intracellular localization	cell cycle regulation	KPNA1(DISRUPTS); E2F4(DISRUPTS)		1200; 15571608	3	0	0		
epsin 1	Motility/polarity/chemotaxis; Vesicle protein	Q9Y6I3	29924	EPN1	19q13.42	human	S382	PHOSPHORYLATION	3178200	FSDPWGGsPAKPSTN		molecular association, regulation		AP2A1(DISRUPTS); REPS2(DISRUPTS)		8751	1	0	0	Phosphorylation inhibits binding  during mitosis. S357D mutation lost effect of insulin-dependent endocytosis.; Phosphorylation inhibits  during mitosis	
BRCA1	EC 6.3.2.-; Nuclear receptor co-regulator; Transcription, coactivator/corepressor; Tumor suppressor; UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase	P38398	672	BRCA1	17q21	human	T509	PHOSPHORYLATION	448039	LKRKRRPtSGLHPED		intracellular localization	transcription, altered			2708109	3	5	70		
SYN1	Vesicle protein	O88935	20964	Syn1		mouse	Y301	PHOSPHORYLATION	478277	VVALTKTyATAEPFI	Synapsin_C		exocytosis, altered			14784600	2	0	2		
girdin	Actin binding protein	Q3V6T2	55704	CCDC88A	2p16.1	human	S1417	PHOSPHORYLATION	456477	INRERQKsLTLTPTR		molecular association, regulation; intracellular localization	cell motility, altered; cytoskeletal reorganization	ACTB(INDUCES)		6743	2	4	1		
Rad51	DNA repair; Mitochondrial	Q06609	5888	RAD51	15q15.1	human	Y315	PHOSPHORYLATION	448324	ETRICKIyDSPCLPE	Rad51	molecular association, regulation	cell cycle regulation; apoptosis, altered	Rad51(DISRUPTS)		7153; 1360	3	0	0		
HSP27	Chaperone; Motility/polarity/chemotaxis	P14602	15507	Hspb1		mouse	S86	PHOSPHORYLATION	448403	RALNRQLsSGVSEIR		activity, induced; intracellular localization	apoptosis, inhibited			5201	44	56	263		
Shc1	Adaptor/scaffold; Apoptosis; Mitochondrial; Motility/polarity/chemotaxis	P29353	6464	SHC1	1q21	human	Y427	PHOSPHORYLATION	448511	ELFDDPSyVNVQNLD		molecular association, regulation	apoptosis, altered; cell motility, altered; cell growth, altered	Grb2(NOT_REPORTED); PPP2CA(DISRUPTS); Grb2(INDUCES)		10351400; 782; 7309804; 5970; 7309803; 6149	36	61	1965		
VAV1	Guanine nucleotide exchange factor, Rac/Rho; Motility/polarity/chemotaxis	P15498	7409	VAV1	19p13.2	human	Y836	PHOSPHORYLATION	14652800	VGWFPANyVEEDYSE			carcinogenesis, altered; cell growth, altered			14551403	1	0	0		
MEK1	EC 2.7.12.2; KINASE; Kinase, protein; Protein kinase, STE; Protein kinase, dual-specificity	Q01986	170851	Map2k1		rat	T292	PHOSPHORYLATION	448287	ETPPRPRtPGRPLSS	Pkinase	enzymatic activity, inhibited				1816	10	1	0		
HDAC4	DEACETYLASE; Deacetylase; EC 3.5.1.98; Hydrolase; Nuclear receptor co-regulator	P56524	9759	HDAC4	2q37.3	human	S246	PHOSPHORYLATION	448488	FPLRKTAsEPNLKLR		molecular association, regulation; intracellular localization	transcription, altered	14-3-3 beta(INDUCES); 14-3-3 epsilon(INDUCES)		2586; 1116; 9006	4	7	17		
MuSK	EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Protein kinase, TK; Protein kinase, tyrosine (receptor)	Q62838		Musk		rat	Y750	PHOSPHORYLATION	3146801	FGLSRNIySADYYKA	Pkinase_Tyr	phosphorylation; enzymatic activity, induced				2848000	1	2	0	 promotes MuSK phosphorylation; promotes AChRb clustering and phosphorylation	
FLI	Actin binding protein; Nuclear receptor co-regulator	Q13045	2314	FLII	17p11.2	human	S436	PHOSPHORYLATION	470489	RLRRRKDsAQDDQAK			transcription, induced			25785422	1	12	196	may induce transcription of the estrogen receptor	
Jun	Transcription factor	P05412	3725	JUN	1p32-p31	human	T8	PHOSPHORYLATION	17737604	MTAKMETtFYDDALN	Jun		carcinogenesis, altered; cell growth, altered			17675043	1	0	0		
EphA2	EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Protein kinase, TK; Protein kinase, tyrosine (receptor)	P29317	1969	EPHA2	1p36	human	Y930	PHOSPHORYLATION	457516	EHFMAAGyTAIEKVV	SAM_1	molecular association, regulation; enzymatic activity, induced	cell differentiation, altered	VAV3(INDUCES); PIK3R1(INDUCES)		4254811	1	3	12		
PDGFRA	EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Protein kinase, TK; Protein kinase, tyrosine (receptor)	P16234	5156	PDGFRA	4q12	human	Y988	PHOSPHORYLATION	450905	RVDSDNAyIGVTYKN		molecular association, regulation		PLCG1(INDUCES)		3744	3	3	17		
DAP3	Apoptosis; Mitochondrial; Nuclear receptor co-regulator	P51398	7818	DAP3	1q22	human	T237	PHOSPHORYLATION	2226209	ITRVRNAtDAVGIVL	DAP3		apoptosis, induced			2195711	1	0	0		
TAB1	Activator protein; Motility/polarity/chemotaxis	Q15750	10454	TAB1	22q13.1	human	S423	PHOSPHORYLATION	456222	QMVNGAHsASTLDEA		activity, inhibited; phosphorylation				7549215; 4328	7	0	0	inhibits phosphorylation of TAK1; inhibits TAK1 T187 phosphorylation	
PLM	Cell surface; Channel, misc.; Membrane protein, integral	O00168	5348	FXYD1	19q13.1	human	S83	PHOSPHORYLATION	451424	EEGTFRSsIRRLSTR	IncA	molecular association, regulation		ATP1A1(DISRUPTS); PLM(INDUCES)		18021013	18	13	60	enhances PLM oligomerization and modulates its interaction with Na/K-ATPase (NKA)	
GTF2I	DNA binding protein; Transcription, coactivator/corepressor	P78347	2969	GTF2I	7q11.23	human	Y249	PHOSPHORYLATION	459606	ESEDPDYyQYNIQAG		activity, induced; intracellular localization	transcription, induced; transcription, altered			14790320; 4667; 4416; 12482269	5	1	1		
CACNA1B	Channel, calcium; Membrane protein, integral; Membrane protein, multi-pass	Q02294	257648	Cacna1b		rat	S1757	PHOSPHORYLATION	465548	FEMLKHMsPPLGLGK		activity, induced				6337819; 7994	2	0	0		
GluR1	Channel, calcium; Channel, ligand-gated; Membrane protein, integral; Membrane protein, multi-pass	P23818	14799	Gria1		mouse	S836	PHOSPHORYLATION	467226	CYKSRSEsKRMKGFC		receptor desensitization, altered; intracellular localization; receptor recycling, altered				3394323; 7910520	7	0	0		
SCN5A	Channel, sodium; Membrane protein, integral; Membrane protein, multi-pass	Q14524	6331	SCN5A	3p21	human	S528	PHOSPHORYLATION	451569	KPRSSRGsIFTFRRR	DUF3451	activity, induced				8548	2	0	0		
NR1H4 iso2	DNA binding protein; Nuclear receptor	Q96RI1-2	9971	NR1H4	12q23.1	human	S135	PHOSPHORYLATION	4245801	VVCGDRAsGYHYNAL	zf-C4	activity, induced; molecular association, regulation	transcription, induced	PGC-1 alpha(INDUCES)		4042525	1	0	0		
DARPP-32	Motility/polarity/chemotaxis; Protein phosphatase, regulatory subunit	Q60829	19049	Ppp1r1b		mouse	T34	PHOSPHORYLATION	448047	MIRRRRPtPAMLFRV	DARPP-32; PPP4R2	activity, induced; phosphorylation; enzymatic activity, induced	transcription, altered			6780; 4264912; 4862618; 2706604; 3256101	53	4	43	sexual receptivity in mice ; histone H3 phosphorylation; Phosphorylation of S566 is necessary for PP2A enzymatic activation and dephosphorylation of DARPP.; required for proper phase-shifting response; Mutation of T34 impaired several behavioral responses to repeated cocaine administration, and abolished acute cocaine-regulated gene expression.	
Spinophilin	Adaptor/scaffold; Protein phosphatase, regulatory subunit	O35274	84686	Ppp1r9b		rat	S94	PHOSPHORYLATION	448728	SDRGVRLsLPRASSL		molecular association, regulation; intracellular localization		ADRA2A(DISRUPTS)		1890; 2425209	6	4	1		
N-WASP	Adaptor/scaffold; Motility/polarity/chemotaxis	O00401	8976	WASL	7q31.3	human	Y256	PHOSPHORYLATION	450253	RETSKVIyDFIEKTG	PBD	activity, induced	cytoskeletal reorganization; cell adhesion, altered			14146314; 19004000	7	36	1347		
eNOS	Amino Acid Metabolism - arginine and proline; EC 1.14.13.39; Oxidoreductase	P70313	18127	Nos3		mouse	S1176	PHOSPHORYLATION	447884	TSRIRTQsFSLQERQ		enzymatic activity, induced				6787	141	8	7		
DAB1 iso2	Adaptor/scaffold	P97318-2	13131	Dab1		mouse	S491	PHOSPHORYLATION	479422	TPAPRQSsPSKSSAS		molecular association, regulation; phosphorylation		CIN85(DISRUPTS)		1713130; 11449	7	0	0		
PPP2R5B	Motility/polarity/chemotaxis; Protein phosphatase, regulatory subunit	Q15173	5526	PPP2R5B	11q12	human	S368	PHOSPHORYLATION	2655004	QVARCVSsPHFQVAE	B56	phosphorylation				2653904	1	0	0	AKT phosphorylation	
GABRG2 iso2	Channel, chloride; Channel, ligand-gated; Membrane protein, integral; Membrane protein, multi-pass	P22723-2	14406	Gabrg2		mouse	Y403	PHOSPHORYLATION	455817	LQERDEEyGYECLDG	Neur_chan_memb	activity, induced				11468	7	0	0	potentiated GABA currents	
CCDC50 iso2	Inhibitor protein	Q8IVM0	152137	CCDC50	3q28	human	Y304	PHOSPHORYLATION	6377636	SSHKGFHyKH_____		phosphorylation	apoptosis, inhibited; cell growth, altered			6376200	1	0	0	 ;  inhibits NF-kB activity; inhibits phosphorylation of IKKbeta through TNFalpha	
IL13R	Membrane protein, integral; Receptor, cytokine	O09030	16164	Il13ra1		mouse	Y402	PHOSPHORYLATION	450931	HWKKYDIyEKQSKEE		molecular association, regulation		STAT3(INDUCES)		3142	1	0	6	Ligand-induced phosphorylation of IL13R slightly increases its association with STAT3;  results in tyrosine phosphorylation of STAT3.	
FBX43	Unknown function	Q4G163	286151	FBXO43	8q22.2	human	S76	PHOSPHORYLATION	12581000	STSSFQDsGYNELKS		protein degradation; ubiquitination				12482299	1	0	0		
ASIC1	Channel, cation; Membrane protein, integral; Membrane protein, multi-pass	P55926	79123	Accn2		rat	S477	PHOSPHORYLATION	449558	QKEAKRSsADKGVAL		activity, inhibited	apoptosis, altered			7326	2	0	0		
JDP2	Nuclear receptor co-regulator; Transcription, coactivator/corepressor	P97875	81703	Jdp2		mouse	T148	PHOSPHORYLATION	448312	VRTDSVRtPESEGNP	Macoilin	protein degradation				20540226	3	2	5		
Daxx	Apoptosis; Nuclear receptor co-regulator; Transcription, coactivator/corepressor	Q9UER7	1616	DAXX	6p21.3	human	S737	PHOSPHORYLATION	467726	PEEIIVLsDSD____	Daxx	sumoylation; molecular association, regulation	apoptosis, altered; transcription, altered	SUMO1(INDUCES); PML(INDUCES)		18837528	1	14	0		
Lmr2	EC 2.7.11.1; KINASE; Kinase, protein; Membrane protein, integral; Membrane protein, multi-pass; Protein kinase, TK; Protein kinase, tyrosine (receptor)	Q8IWU2	22853	LMTK2	7q21.3	human	S1450	PHOSPHORYLATION	4957483	LQTSKYFsPPPPARS		enzymatic activity, induced				22995804	1	6	9		
SERPINA1	Inhibitor protein; Secreted; Secreted, signal peptide	P01009	5265	SERPINA1	14q32.1	human	T416	PHOSPHORYLATION	469611	MGKVVNPtQK_____			cell growth, altered			8798	0	0	0	Phosphorylated C26 peptide did not induce cell increased proliferation and mitogenic action was increased 2 fold compared to unphosphorylated C26. 	
KLC2	Microtubule binding protein; Motor protein	NP_032477	16594	Klc2		mouse	S579	PHOSPHORYLATION	452949	SRMKRASsLNFLNKS		molecular association, regulation		14-3-3 eta(INDUCES)		8598	2	36	61		
PXN	Adaptor/scaffold; Cell adhesion; Cytoskeletal protein; Motility/polarity/chemotaxis	Q66H76	360820	Pxn		rat	S83	PHOSPHORYLATION	451113	YAHQQPPsPSPIYSS	Paxillin		cell adhesion, altered			3267	7	24	36		
ABCC9	Channel, potassium; Membrane protein, integral; Membrane protein, multi-pass; Transporter	P70170	20928	Abcc9		mouse	S1387	PHOSPHORYLATION	483973	HTLRSRLsIILQDPI	ABC_tran	activity, induced; protein conformation				11977; 1968330	2	0	0	Molecular modeling shows phosphorylated S1387 interacts with Y506 and R1462 leading to channel activation.  	
tau iso8	Cytoskeletal protein	P10636-8	4137	MAPT	17q21.1	human	S198	PHOSPHORYLATION	449551	SGDRSGYsSPGSPGT		molecular association, regulation		WWOX(INDUCES); tau(INDUCES)		5955609; 9223	15	11	9	enhances tau aggregation; binding increased by estradiol	
SPRED1	Inhibitor protein	Q924S8	114715	Spred1		mouse	Y377	PHOSPHORYLATION	18899303	LCAESMLyHCMSDSE	Sprouty		cell differentiation, altered; signaling pathway regulation			18837514	1	0	0	inhibits the Ras/ERK pathway	
Notch 1	Membrane protein, integral; Motility/polarity/chemotaxis; Receptor, misc.; Transcription factor	Q01705	18128	Notch1		mouse	T2487	PHOSPHORYLATION	483083	VPEHPFLtPSPESPD	DUF3454	protein degradation; molecular association, regulation; ubiquitination		FBXW7(INDUCES)		11951	1	0	0		
ATP7B	EC 3.6.3.4; Hydrolase; Membrane protein, integral; Membrane protein, multi-pass; Transporter; Vesicle protein	P35670	540	ATP7B	13q14.3	human	S340	PHOSPHORYLATION	25786200	GSGTDHRsSSSHSPG		intracellular localization; protein conformation				25712644	1	0	0	 mutant does not return to TGN in response to copper depletion;  S340/341A mutant shifts ATP7B from trans-Golgi Network (TGN) to vesicles	
HER4	EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Protein kinase, TK; Protein kinase, tyrosine (receptor)	Q15303	2066	ERBB4	2q33.3-q34	human	Y1035	PHOSPHORYLATION	4825102	FNIPPPIyTSRARID		molecular association, regulation		STAT1(INDUCES)		4651319	0	1	0		
IkB-alpha	DNA binding protein; Inhibitor protein	P25963	4792	NFKBIA	14q13	human	S36	PHOSPHORYLATION	448204	RHDSGLDsMKDEEYE		activity, induced; protein degradation; intracellular localization; phosphorylation	apoptosis, altered; apoptosis, induced; apoptosis, inhibited; transcription, induced; transcription, altered			6035; 2512006; 2097; 6802; 4914008; 4859900; 2181; 5638; 5900; 2153; 6934; 1125; 5743; 4914009; 5674; 4914007; 1737; 7178	80	1	5	stress-induced activation of NF-kB ; Phosphorylation  induces NKkB activation and IkB-alpha degradation. ; S32/36A mutant blocks paclitaxel induced downstream effects.	
Deptor	Apoptosis	Q8TB45	64798	DEPTOR	8q24.12	human	T295	PHOSPHORYLATION	4723863	GYFSSSPtLSSSPPV		protein degradation; molecular association, regulation		BTRC(INDUCES)		21699400	2	4	0		
CK1E	EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, CK1; Protein kinase, Ser/Thr (non-receptor)	P49674	1454	CSNK1E	22q13.1	human	T407	PHOSPHORYLATION	453420	SRIPASQtSVPFDHL		enzymatic activity, inhibited				8419; 2331	2	3	1	some subset of these 8 sites	
CSFR	EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Protein kinase, TK; Protein kinase, tyrosine (receptor)	P09581	12978	Csf1r		mouse	Y974	PHOSPHORYLATION	455527	PLLQPNNyQFC____		molecular association, regulation	cell differentiation, altered; cytoskeletal reorganization	Cbl(INDUCES)		4651302; 5410	2	0	0		
SHIP	EC 3.1.3.86; EC 3.1.3.n1; Motility/polarity/chemotaxis; Phosphatase, lipid	Q9ES52	16331	Inpp5d		mouse	S441	PHOSPHORYLATION	15621804	QGKTRDDsADYIPHD	Exo_endo_phos	enzymatic activity, induced				15562509	1	1	0		
PTEN	Carbohydrate Metabolism - inositol phosphate; EC 3.1.3.16; EC 3.1.3.48; EC 3.1.3.67; Motility/polarity/chemotaxis; Nuclear receptor co-regulator; PHOSPHATASE; Phosphatase, lipid; Tumor suppressor	P60484	5728	PTEN	10q23.3	human	T366	PHOSPHORYLATION	449634	ASSSTSVtPDVSDNE		activity, inhibited				6691	4	2	0		
PLCG2	Carbohydrate Metabolism - inositol phosphate; EC 3.1.4.11; Motility/polarity/chemotaxis; Phospholipase	P16885	5336	PLCG2	16q24.1	human	Y759	PHOSPHORYLATION	447941	LYDVSRMyVDPSEIN		molecular association, regulation; enzymatic activity, induced		Lyn(INDUCES)		4801; 5646	9	8	225		
p70S6K	EC 2.7.11.-; EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor); Translation	P23443	6198	RPS6KB1	17q23.1	human	S394	PHOSPHORYLATION	448806	TRQTPVDsPDDSTLS	Pkinase_C	activity, induced; protein conformation; enzymatic activity, induced				1972; 11751; 2702	10	1	9		
LRP2	Membrane protein, integral; Motility/polarity/chemotaxis; Receptor, misc.	P98164	4036	LRP2	2q31.1	human	S4587	PHOSPHORYLATION	767905	WNLFKRKsKQTTNFE		receptor internalization, altered; receptor recycling, altered				762703	1	0	0		
RSK2	EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor)	P51812	6197	RPS6KA3	Xp22.2-p22.1	human	Y529	PHOSPHORYLATION	464205	TITKTVEyLHAQGVV	Pkinase; tRNA-synt_1f	molecular association, regulation	apoptosis, altered	ERK2(INDUCES); ERK1(INDUCES); FGFR3(INDUCES)		3475709; 1173402	2	1	4	FGFR3 phosphorylates RSK2 at Y529 which facilitates inactive ERK binding to RSK2.	
PXN	Adaptor/scaffold; Cell adhesion; Cytoskeletal protein; Motility/polarity/chemotaxis	P49024	395832	PXN		chicken	Y31	PHOSPHORYLATION	448785	FLTEETPySYPTGNH		molecular association, regulation	cytoskeletal reorganization	Crk(INDUCES); CDK6(INDUCES)		5011229; 2049	35	6	64		
Mos	EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor)	P00536	17451	Mos		mouse	S50	PHOSPHORYLATION	448658	PSEGVMPsPLSLCRY		protein conformation; enzymatic activity, induced				2604	3	1	0	in vitro	
KIR3DL1	Membrane protein, integral; Receptor, misc.	P43629	3811	KIR3DL1	19q13.4	human	S415	PHOSPHORYLATION	990302	QRKITRPsQRPKTPP		activity, induced; receptor internalization, altered				970025	1	0	0		
geminin	Cell cycle regulation; Motility/polarity/chemotaxis	O75496	51053	GMNN	6p22.3	human	S200	PHOSPHORYLATION	475942	TCAEGTVsSSTDAKP	Fmp27_WPPW		apoptosis, altered			9237	1	0	0	regulates geminin cleavage by caspase-3	
STAT5A	DNA binding protein; Motility/polarity/chemotaxis; Transcription factor	P42231	443419	STAT5A		sheep	T757	PHOSPHORYLATION	447766	GEFDLDEtMDVARHV		intracellular localization	transcription, inhibited			1285	2	0	0		
MEK5	EC 2.7.12.2; KINASE; Kinase, protein; Protein kinase, STE; Protein kinase, dual-specificity	Q13163	5607	MAP2K5	15q23	human	S311	PHOSPHORYLATION	448621	VSTQLVNsIAKTYVG	Pkinase	molecular association, regulation; intracellular localization; enzymatic activity, induced		ERK5(DISRUPTS)		5457; 2642	2	2	0	MEK5-alpha isoform, not beta	
CAMK2A	EC 2.7.11.17; KINASE; Kinase, protein; Protein kinase, CAMK; Protein kinase, Ser/Thr (non-receptor)	P11275	25400	Camk2a		rat	T306	PHOSPHORYLATION	449596	LKGAILTtMLATRNF		molecular association, regulation; enzymatic activity, inhibited	cytoskeletal reorganization	calmodulin(DISRUPTS)		3796; 15331009; 2852600	13	6	1	regulate synaptic strength 	
ADD2	Cytoskeletal protein; Motility/polarity/chemotaxis	P35612	119	ADD2	2p13.3	human	S600	PHOSPHORYLATION	481589	PAKSAPAsPVQSPAK			cell growth, induced; cytoskeletal reorganization			23940900	2	17	1		
calsequestrin 1	Calcium-binding protein; Mitochondrial	P07221	100009095	CASQ1		rabbit	T381	PHOSPHORYLATION	451337	VLEGEINtEDDDDED	Calsequestrin	molecular association, regulation		ASPH(INDUCES)		2451815	3	0	0	increases Ca2+ binding capacity of calsequestrin 1	
ADRA1B	GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR	P18841		ADRA1B		hamster	S408	PHOSPHORYLATION	451005	RKDSLDDsGSCMSGS		receptor desensitization, altered				3257	1	2	2		
PELI1	Adaptor/scaffold; EC 6.3.2.-; EC 6.3.2.19; Ligase; UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase	Q96FA3	57162	PELI1	2p13.3	human	T86	PHOSPHORYLATION	7388011	YTLSRAQtVVVEYTH	Pellino	ubiquitination; enzymatic activity, induced				7228504	2	0	0		
NPY1R	GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR	P21555	29358	Npy1r		rat	T361	PHOSPHORYLATION	455139	MHTDVSKtSLKQASP		receptor desensitization, altered; receptor internalization, altered				4358	1	0	0	may be an artifact of the truncation mutants	
TRPM8	Channel, cation; Membrane protein, integral; Membrane protein, multi-pass	Q7Z2W7	79054	TRPM8	2q37.1	human	S9	PHOSPHORYLATION	12570903	SFRAARLsMRNRRND		activity, induced				12525219	1	0	0		
TGFBR2	EC 2.7.11.30; KINASE; Kinase, protein; Membrane protein, integral; Protein kinase, Ser/Thr (receptor); Protein kinase, TKL	P37173	7048	TGFBR2	3p22	human	S409	PHOSPHORYLATION	452048	LRLDPTLsVDDLANS	Pkinase	enzymatic activity, induced				3992	1	4	0		
NRF2	DNA binding protein; Transcription factor	Q60795	18024	Nfe2l2		mouse	Y568	PHOSPHORYLATION	460703	RDEDGKPySPSEYSL		protein degradation; molecular association, regulation; intracellular localization		exportin 1(INDUCES)		7749	4	0	1	required for nuclear export of Nrf2	
EphA3	EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Protein kinase, TK; Protein kinase, tyrosine (receptor)	P29320	2042	EPHA3	3p11.2	human	Y779	PHOSPHORYLATION	448910	EDDPEAAyTTRGGKI	Pkinase_Tyr	molecular association, regulation; enzymatic activity, induced	cytoskeletal reorganization; cell adhesion, altered	Crk(INDUCES)		2462	3	21	724		
TSC2	Cell cycle regulation; GTPase activating protein, misc.; Nuclear receptor co-regulator; Tumor suppressor	P49815	7249	TSC2	16p13.3	human	S939	PHOSPHORYLATION	448501	SFRARSTsLNERPKS		molecular association, regulation; intracellular localization; activity, inhibited; phosphorylation	apoptosis, inhibited; transcription, altered	14-3-3 zeta(INDUCES); 14-3-3 epsilon(INDUCES); 14-3-3 gamma(INDUCES)		4158; 7859; 5955618; 2362505	15	11	50		
NFkB-p65	DNA binding protein; Nuclear receptor co-regulator; Transcription factor	Q04206	5970	RELA	11q13	human	T505	PHOSPHORYLATION	455490	EAITRLVtGAQRPPD			cell growth, inhibited; apoptosis, inhibited; cytoskeletal reorganization; cell motility, inhibited; transcription, altered			22343615	3	0	0	induces NOXA gene expression	
EpoR	EC 2.7.10.2; Membrane protein, integral; Receptor, cytokine	P19235	2057	EPOR	19p13.3-p13.2	human	Y309	PHOSPHORYLATION	3133300	GNFQLWLyQNDGCLW		phosphorylation	cell growth, altered			8493	1	0	0		
Kit	EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Protein kinase, TK; Protein kinase, tyrosine (receptor)	P10721	3815	KIT	4q11-q12	human	Y570	PHOSPHORYLATION	448015	INGNNYVyIDPTQLP		activity, induced; molecular association, regulation; enzymatic activity, induced	cell growth, altered	CTK(INDUCES); SHP-1(INDUCES)		13852012; 1032; 22518522; 10274611	7	2	12		
InsR	EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Protein kinase, TK; Protein kinase, tyrosine (receptor)	P06213	3643	INSR	19p13.3-p13.2	human	S1221	PHOSPHORYLATION	3103703	TTSSDMWsFGVVLWE	Pkinase_Tyr	enzymatic activity, induced				8572	1	0	0		
p53	Activator protein; DNA binding protein; Motility/polarity/chemotaxis; Nuclear receptor co-regulator; Transcription factor; Tumor suppressor	P04637	7157	TP53	17p13.1	human	S371	PHOSPHORYLATION	447533	AHSSHLKsKKGQSTS		activity, induced; molecular association, regulation; activity, inhibited			DNA(INDUCES)	7991101; 1208	4	0	0		
AML3	DNA binding protein; Transcription factor	Q13950	860	RUNX2	6p21	human	S118	PHOSPHORYLATION	460037	AELVRTDsPNFLCSV	Suf; TFIIA; DUF2828; Med15; Runt	protein degradation; molecular association, regulation; activity, inhibited	transcription, altered	CBFB(DISRUPTS)		7652; 8789	3	0	0		
FAK iso3	EC 2.7.1.112; EC 2.7.10.2; KINASE; Kinase, protein; Protein kinase, TK; Protein kinase, tyrosine (non-receptor)	P34152-3	14083	Ptk2		mouse	S732	PHOSPHORYLATION	450196	SSEGFYPsPQHMVQT		intracellular localization	cytoskeletal reorganization			2870	5	1	0	Expression of GFP-FAK-S732A mutant results in altered neuronal positioning. abnormal nuclear morphology, and affects nuclear movement in cultured neurons.  	
FPR1	GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Motility/polarity/chemotaxis; Receptor, GPCR	P21462	2357	FPR1	19q13.4	human	T331	PHOSPHORYLATION	450666	LTEDSTQtSDTATNS		receptor desensitization, altered; receptor internalization, altered				3130	2	0	0		
PAK4	EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, STE; Protein kinase, Ser/Thr (non-receptor)	O96013	10298	PAK4	19q13.2	human	S474	PHOSPHORYLATION	448023	KEVPRRKsLVGTPYW	Pkinase	intracellular localization; enzymatic activity, induced	cell growth, altered			2852659; 18378511	4	36	91		
MAZ	C2H2-type zinc finger protein; Transcription factor	O97600	100008693	MAZ		rabbit	S187	PHOSPHORYLATION	449094	ALEKKRKsKGPYICA		protein conformation; activity, inhibited	transcription, inhibited		DNA(DISRUPTS)	2124	1	0	0		
CADPS	Vesicle protein	Q62717	26989	Cadps		rat	S7	PHOSPHORYLATION	7712501	_MLDPSSsEEESDEI		activity, induced	exocytosis, altered			7601405	1	1	0		
CHD-4	DNA binding protein; EC 3.6.1.-; EC 3.6.4.12; Helicase	Q14839	1108	CHD4	12p13	human	S1349	PHOSPHORYLATION	481897	QVNYNDGsQEDRDWQ	DUF1087	molecular association, regulation; intracellular localization			DNA(NOT_REPORTED)	18021502	1	5	2	required for efficient repair of double strand DNA breaks	
FLOT2	Cell adhesion	Q9Z2S9	83764	Flot2		rat	Y27	PHOSPHORYLATION	1270905	CGSDYKQyVFGGWAW	Band_7	intracellular localization	cell motility, altered; cytoskeletal reorganization			9297	1	0	0		
E2F1	DNA binding protein; Transcription factor	Q01094	1869	E2F1	20q11.2	human	S332	PHOSPHORYLATION	447868	TDSATIVsPPPSSPP		molecular association, regulation	cell cycle regulation	Rb(DISRUPTS); E4(INDUCES)		1337	2	0	0		
FGFR1	EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Protein kinase, TK; Protein kinase, tyrosine (receptor)	P11362	2260	FGFR1	8p12	human	Y154	PHOSPHORYLATION	448774	NRMPVAPyWTSPEKM		protein degradation; receptor desensitization, altered; receptor internalization, altered	cytoskeletal reorganization			1090; 2697	4	1	0		
MKP-3	EC 3.1.3.16; EC 3.1.3.48; Motility/polarity/chemotaxis; Protein phosphatase, dual-specificity	Q9DBB1	67603	Dusp6		mouse	S197	PHOSPHORYLATION	455266	SATDSDGsPLSNSQP		protein degradation	signaling pathway regulation			26349400	4	0	0	represses expression of gluconeogenic genes and glucose output	
CTNNB1	Actin binding protein; Cell adhesion; Motility/polarity/chemotaxis; Nuclear receptor co-regulator; Transcription factor	Q02248	12387	Ctnnb1		mouse	S37	PHOSPHORYLATION	447582	YLDSGIHsGATTTAP		protein degradation; ubiquitination				4787; 4969204	53	3	2		
TOB1	Adaptor/scaffold; Cell cycle regulation	P50616	10140	TOB1	17q21	human	S152	PHOSPHORYLATION	455535	PASSVSSsPSPPFGH		activity, inhibited	cell cycle regulation; cell growth, altered			5435; 5416	3	0	0	the antiproliferative activity of TOB1 is inhibited by phosphorylation.; the antiproliferative function of TOB1 is inhibited by phosphorylation.	
AhR	DNA binding protein; Nuclear receptor; Transcription factor	P30561	11622	Ahr		mouse	S67	PHOSPHORYLATION	451013	INKLDKLsVLRLSVS	HLH	intracellular localization				3263	1	0	0		
DNAPK	DNA repair; EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, ATYPICAL; Protein kinase, Ser/Thr (non-receptor)	P78527	5591	PRKDC	8q11	human	T2647	PHOSPHORYLATION	448713	QQHDFTLtQTADGRS			chromatin organization, altered; cell growth, altered			9570	8	7	8	increases survival in ionizing radiation and repairing double strand DNA breaks	
CDCA5	Cell cycle regulation	Q96FF9	113130	CDCA5	11q12.1	human	S209	PHOSPHORYLATION	3208965	DMTLPGIsPPPEKQK	Sororin		carcinogenesis, altered; cell growth, altered			14784604	2	6	0		
RasGRF1	Guanine nucleotide exchange factor, Ras	P27671	19417	Rasgrf1		mouse	S737	PHOSPHORYLATION	469604	PLAIGTSsPSRRRKL	RasGEF_N	protein degradation				8268	1	2	1	controls nuclear organization in cortical neurons	
Brk	EC 2.7.10.2; KINASE; Kinase, protein; Protein kinase, TK; Protein kinase, tyrosine (non-receptor)	Q13882	5753	PTK6	20q13.3	human	Y342	PHOSPHORYLATION	450274	RLIKEDVyLSHDHNI	Pkinase_Tyr	enzymatic activity, induced		Brk(INDUCES)		2985; 2983	2	2	45		
FZR1	Ubiquitin conjugating system	Q9UM11	51343	FZR1	19p13.3	human	S40	PHOSPHORYLATION	3215931	PASSPVSsPSKHGDR		activity, inhibited	apoptosis, induced			4641433	1	9	2	inhibits cyclin B1 degradation	
HOXB7	DNA binding protein; Motility/polarity/chemotaxis; Transcription factor	P09629	3217	HOXB7	17q21.3	human	T203	PHOSPHORYLATION	465571	NKTAGPGtTGQDRAE			cell differentiation, altered			8028	1	0	0		
SNAP-91	Vesicle protein	O60641	9892	SNAP91	6q14.2	human	S313	PHOSPHORYLATION	454326	SPATTVTsPNSTPAK		molecular association, regulation		PLD1(INDUCES)		18415111	2	7	5		
Bim	Apoptosis	O88498	64547	Bcl2l11		rat	T110	PHOSPHORYLATION	449070	PMSCDKStQTPSPPC			apoptosis, induced			2106	1	0	0		
PXN	Adaptor/scaffold; Cell adhesion; Cytoskeletal protein; Motility/polarity/chemotaxis	Q66H76	360820	Pxn		rat	S130	PHOSPHORYLATION	450228	KQKSAEPsPTVMSSS	Paxillin	intracellular localization				7852	5	14	4	necessary for formation of NGF-induced neurite extensions 	
SCN2A	Channel, sodium; Membrane protein, integral; Membrane protein, multi-pass	P04775	24766	Scn2a		rat	S1126	PHOSPHORYLATION	6003507	TEEFSSEsDMEESKE	Na_trans_assoc	intracellular localization				5930021	1	0	0	regulates SCN2A accumulation at the axonal initial segment (AIS) and interaction with ankyrin G	
MMP14	EC 3.4.24.80; Membrane protein, integral; Motility/polarity/chemotaxis; Protease	P50281	4323	MMP14	14q11.2	human	T567	PHOSPHORYLATION	7992400	FFFRRHGtPRRLLYC	DUF3377	molecular association, regulation; intracellular localization; phosphorylation	cell motility, altered; cell growth, altered	ITGA5(INDUCES)		7889918; 21683713	3	0	0	 increases cell migration and invasion ; required for MMP14 internalization and trafficking	
ERMN		Q5RJL0		Ermn		rat	S278	PHOSPHORYLATION	3215796	QRIDEFEsMMHL___	ERM	molecular association, regulation; intracellular localization; activity, inhibited	cytoskeletal reorganization	ACTB(DISRUPTS)		15022712	1	18	27		
MKK6 iso2	EC 2.7.12.2; KINASE; Kinase, protein; Protein kinase, STE; Protein kinase, dual-specificity	P52564-2	5608	MAP2K6	17q24.3	human	T155	PHOSPHORYLATION	448195	LVDSVAKtIDAGCKP	Pkinase	enzymatic activity, induced				716	2	2	1		
Jun	Transcription factor	P05412	3725	JUN	1p32-p31	human	T239	PHOSPHORYLATION	450450	VPEMPGEtPPLSPID	Jun; DUF3450	molecular association, regulation; ubiquitination		FBXW7(INDUCES); FBXW7(DISRUPTS)		22599404; 6610	5	8	11	Rack,1 FBXW7, and Jun form a heterodimer.Phosphorylated Jun is released and not ubiquitinated.   	
MDM2	EC 6.3.2.-; EC 6.3.2.19; Inhibitor protein; Ligase; UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase	Q00987	4193	MDM2	12q14.3-q15	human	S166	PHOSPHORYLATION	448130	SSRRRAIsETEENSD		activity, induced; molecular association, regulation; protein stabilization; ubiquitination; intracellular localization; enzymatic activity, induced	cell cycle regulation; apoptosis, altered; translation, altered	ARF1(INDUCES); p300(INDUCES)		6331301; 5219; 6268; 17613017; 2337; 8546; 4313601; 4131	30	6	5	increases HIF-1alpha expression	
BCAP	Adaptor/scaffold	Q9DDT2	374268	PIK3AP1		chicken	Y199	PHOSPHORYLATION	450043	CGVQTTVyIIMKCRL		molecular association, regulation		PIK3R1(INDUCES)		1374	1	0	0		
ADORA3	GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR	P28647	25370	Adora3		rat	T307	PHOSPHORYLATION	450328	RACRLCQtSDSLDSN		receptor desensitization, altered				3050	1	0	0		
H3	DNA binding protein	P68433	360198	Hist1h3a		mouse	K10	ACETYLATION	463820	RTKQTARkSTGGKAP		molecular association, regulation	transcription, altered		DNA(INDUCES)	7124718; 15031328	132	8	326	T gondii infection inhibited H3-mediated TNF transcription.	
GCP6	Cytoskeletal protein; Motility/polarity/chemotaxis	Q96RT7	85378	TUBGCP6	22q13.31-q13.33	human	S1397	PHOSPHORYLATION	472628	EDTAAQSsPGRGEEA	Spc97_Spc98		cytoskeletal reorganization			9167	1	1	0	role in the attachment of microtubule-organizing centers (MTOC) to IFs in epithelial cells 	
AML3	DNA binding protein; Transcription factor	Q13950	860	RUNX2	6p21	human	T200	PHOSPHORYLATION	27728400	RGKSFTLtITVFTNP	Runt	molecular association, regulation	transcription, induced		DNA(INDUCES)	27623402	1	0	0	induction of MMP3 and MMP9 transcription, invasion of breast cancer cells	
XRCC1	DNA repair	P18887	7515	XRCC1	19q13.2	human	S475	PHOSPHORYLATION	451509	IDIEGVQsEGQDNGA		molecular association, regulation; intracellular localization		Pnk1(INDUCES)		3651	2	3	0	regulates rapid repair of cellular DNA single-strand breaks	
TXA2-R iso2	GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR	P21731-2	6915	TBXA2R	19p13.3	human	S239	PHOSPHORYLATION	469628	AQQRPRDsEVEMMAQ	7tm_1	molecular association, regulation; receptor desensitization, altered; receptor internalization, altered		ARRB2(INDUCES)		8248	2	0	0		
BRCA1	EC 6.3.2.-; Nuclear receptor co-regulator; Transcription, coactivator/corepressor; Tumor suppressor; UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase	P38398	672	BRCA1	17q21	human	S632	PHOSPHORYLATION	478486	LVVSRNLsPPNCTEL			transcription, altered			9578	1	1	0	inhibits transcription by interfering with DNA-binding ability of BRCA1	
Src	EC 2.7.10.2; KINASE; Kinase, protein; Protein kinase, TK; Protein kinase, tyrosine (non-receptor)	P00523	396442	SRC		chicken	Y527	PHOSPHORYLATION	448235	FTSTEPQyQPGENL_		molecular association, regulation; enzymatic activity, inhibited; phosphorylation	cell motility, altered; cytoskeletal reorganization; cell adhesion, altered; cell growth, altered	CSK(INDUCES); CSK(DISRUPTS)		1277; 2566; 5870; 3391001; 2558; 5854; 791; 5309422; 4317115; 2557; 788	104	13	966		
LAT	Adaptor/scaffold; Membrane protein, integral	O54957	16797	Lat		mouse	Y235	PHOSPHORYLATION	448006	DGEEAPDyENLQELN		phosphorylation				4228	9	2	76	regulates exocytosis and cytokine secretion	
APBA2	Adaptor/scaffold	P98084	11784	Apba2		mouse	S239	PHOSPHORYLATION	7151800	AEIKMSLsMTSITSA		molecular association, regulation		APP(INDUCES)		6829235	1	0	0		
XRCC1	DNA repair	P18887	7515	XRCC1	19q13.2	human	S525	PHOSPHORYLATION	451451	STDENTDsEEHQEPP		molecular association, regulation; intracellular localization		Pnk1(INDUCES)		3651	1	2	3	regulates rapid repair of cellular DNA single-strand breaks	
DVL2	Adaptor/scaffold; Motility/polarity/chemotaxis	O14641	1856	DVL2	17p13.1	human	T224	PHOSPHORYLATION	25538000	MSRFSSStEQSSASR	Dishevelled	molecular association, regulation; intracellular localization	cytoskeletal reorganization	PLK1(INDUCES)		25347040	1	1	0	important for cilia resorption	
cofilin 1	Cytoskeletal protein; Motility/polarity/chemotaxis	P45592	29271	Cfl1		rat	S3	PHOSPHORYLATION	448444	_____MAsGVAVSDG		intracellular localization; activity, inhibited	cell motility, altered; cytoskeletal reorganization			6413; 646; 3548303; 645	52	32	2		
FLCN		Q76JQ2	303185	Flcn		rat	S62	PHOSPHORYLATION	3206874	SSRVRAHsPAEGAST		molecular association, regulation		AMPKA1(INDUCES)		12558749; 10433001	3	22	5		
BKR2	GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR	P25023	25245	Bdkrb2		rat	Y161	PHOSPHORYLATION	452084	MLVSIDRyLALVKTM	7tm_1	activity, induced; receptor desensitization, altered				7063	2	2	0		
IRF3	DNA binding protein; Transcription factor	Q14653	3661	IRF3	19q13.3-q13.4	human	S396	PHOSPHORYLATION	449028	NTVDLHIsNSHPLSL		activity, induced; protein degradation; molecular association, regulation; intracellular localization	transcription, altered	IRF3(INDUCES); CBP(INDUCES)		2061; 4260506; 3416; 14551405; 2062; 6337817; 2195490	20	2	0		
IREB1	Carbohydrate Metabolism - citrate (TCA) cycle; Carbohydrate Metabolism - glyoxylate and dicarboxylate; EC 4.2.1.3; Endoplasmic reticulum; Lyase; RNA binding protein; Translation	P21399	48	ACO1	9p21.1	human	S711	PHOSPHORYLATION	455225	REFNSYGsRRGNDAV	Aconitase_C	activity, inhibited				4401	3	0	0		
DOR-1	GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR	P32300	18386	Oprd1		mouse	T361	PHOSPHORYLATION	448551	RERVTACtPSDGPGG		intracellular localization				18119118	3	1	0		
AR	DNA binding protein; Nuclear receptor; Transcription factor	P10275	367	AR	Xq12	human	Y223	PHOSPHORYLATION	1243004	PTSSKDNyLGGTSTI	Androgen_recep		transcription, induced			28723103	1	1	0	PSA expression	
p70S6K	EC 2.7.11.-; EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor); Translation	P67999	83840	Rps6kb1		rat	T252	PHOSPHORYLATION	448606	HDGTVTHtFCGTIEY	Pkinase	enzymatic activity, induced				2717; 735	27	3	8		
EpoR	EC 2.7.10.2; Membrane protein, integral; Receptor, cytokine	P19235	2057	EPOR	19p13.3-p13.2	human	Y456	PHOSPHORYLATION	455532	PPHLKYLyLVVSDSG		molecular association, regulation	apoptosis, inhibited	SHIP(INDUCES); SOCS3(INDUCES)		8833; 5412; 8494	6	0	0		
SNAP-25	Vesicle protein	P60880	6616	SNAP25	20p12-p11.2	human	T138	PHOSPHORYLATION	449875	GGFIRRVtNDARENE	Exonuc_VII_L; SNAP-25	molecular association, regulation		STX1A(DISRUPTS); SYT1(DISRUPTS)		9596	4	3	3		
PDK1	EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor)	Q9Z2A0	18607	Pdpk1		mouse	T516	PHOSPHORYLATION	450132	PEAKNFKtFFVHTPN		enzymatic activity, induced				2738	5	3	0		
InsR	EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Protein kinase, TK; Protein kinase, tyrosine (receptor)	P06213	3643	INSR	19p13.3-p13.2	human	S1064	PHOSPHORYLATION	451563	KTVNESAsLRERIEF	Pkinase_Tyr	phosphorylation				8570	2	1	1	alanine mutations of S1033, S1062, and S1064 increases tyrosine autophosphorylation of InsR	
TGFBR2	EC 2.7.11.30; KINASE; Kinase, protein; Membrane protein, integral; Protein kinase, Ser/Thr (receptor); Protein kinase, TKL	P37173	7048	TGFBR2	3p22	human	Y336	PHOSPHORYLATION	2869603	AKGNLQEyLTRHVIS	Pkinase	enzymatic activity, induced	transcription, altered			2852639	2	0	0		
Bid	Apoptosis; Mitochondrial	P70444	12122	Bid		mouse	S61	PHOSPHORYLATION	448404	DELQTDGsQASRSFN	BID	protein stabilization	cell cycle regulation; apoptosis, inhibited			1368; 6761	3	0	0		
PAK1	EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, STE; Protein kinase, Ser/Thr (non-receptor)	Q13153	5058	PAK1	11q13-q14	human	S21	PHOSPHORYLATION	448174	APPMRNTsTMIGAGS		intracellular localization	cytoskeletal reorganization			1934800	3	0	10	No effect on VASP binding.  S21A Pak1 mutation effects localization of Pak1 and cell polarization.	
LIG1	DNA repair; EC 6.5.1.1; Ligase	P18858	3978	LIG1	19q13.2-q13.3	human	S91	PHOSPHORYLATION	2999200	ALDCSQVsPPRPATS		molecular association, regulation; intracellular localization; phosphorylation	cell growth, altered	RFC1(INDUCES); Rad17(DISRUPTS)		7072901; 8424	3	6	1	primes other LIG1 phosphorylations; regulates DNA replication and repair	
Kv11.1	Channel, potassium; Membrane protein, integral; Membrane protein, multi-pass; Motility/polarity/chemotaxis	Q12809	3757	KCNH2	7q36.1	human	S283	PHOSPHORYLATION	4696779	CASVRRAsSADDIEA		activity, induced; molecular association, regulation; activity, inhibited		14-3-3 eta(INDUCES)		10293701; 10292905	3	2	0	rapid reduction in channel current; 14-3-3 binding stabilizes phosphorylation of KV11.1, prolonging its activation	
Deptor	Apoptosis	Q8TB45	64798	DEPTOR	8q24.12	human	S287	PHOSPHORYLATION	4723848	SMSSCGSsGYFSSSP		protein degradation; molecular association, regulation; ubiquitination		BTRC(INDUCES); FBW1B(INDUCES)		21699401; 21683709	3	2	0		
YY1	C2H2-type zinc finger protein; Cell development/differentiation; Transcription factor	P25490	7528	YY1	14q	human	S184	PHOSPHORYLATION	476106	GKKSGKKsYLSGGAG		molecular association, regulation			DNA(INDUCES)	27257061	1	1	0		
HCN4	Channel, cation; Membrane protein, integral; Membrane protein, multi-pass	Q9Y3Q4	10021	HCN4	15q24.1	human	Y531	PHOSPHORYLATION	1240811	RRQYQEKyKQVEQYM		activity, induced				1172821	1	0	0		
DCP1A	EC 3.-.-.-; Hydrolase; RNA processing; Transcription, coactivator/corepressor	Q91YD3	75901	Dcp1a		mouse	S339	PHOSPHORYLATION	3213297	LPLSPVLsPTLPAEA		molecular association, regulation		DCP2(INDUCES)		27902366	2	14	6		
Smad2	DNA binding protein; Transcription factor	Q15796	4087	SMAD2	18q21.1	human	T8	PHOSPHORYLATION	448792	MSSILPFtPPVVKRL		activity, induced; protein stabilization; molecular association, regulation	transcription, induced	Smad4(INDUCES)		1956	3	10	0		
CCR7	GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Motility/polarity/chemotaxis; Receptor, GPCR	P32248	1236	CCR7	17q12-q21.2	human	T374	PHOSPHORYLATION	455289	SVEAETTtTFSP___		phosphorylation				4472	1	0	0	ERK1/2 phosphorylation	
WAVE1	Cytoskeletal protein; Motility/polarity/chemotaxis	Q5BJU7		Wasf1		rat	S310	PHOSPHORYLATION	4764996	LIENRPQsPAAGRTP		intracellular localization	cytoskeletal reorganization			7910501	3	6	0		
LKB1	Autophagy; EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, CAMK; Protein kinase, Ser/Thr (non-receptor)	Q15831	6794	STK11	19p13.3	human	S428	PHOSPHORYLATION	448147	SSKIRRLsACKQQ__		molecular association, regulation; intracellular localization; phosphorylation; enzymatic activity, induced	cell growth, altered	STRAD(INDUCES); exportin 1(INDUCES)		4215303; 3249403; 7709700	21	2	0	; in the presence of ONOO(-);  supresses angiogenesis	
SPHK2	EC 2.7.1.-; EC 2.7.1.91; Kinase, lipid; Lipid Metabolism - sphingolipid	Q9NRA0	56848	SPHK2	19q13.2	human	S387	PHOSPHORYLATION	477181	PATVEPAsPTPAHSL			cell motility, altered			9377	1	3	0		
HER3	EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Protein kinase, TK; Protein kinase, tyrosine (receptor)	Q62799	29496	Erbb3		rat	Y1051	PHOSPHORYLATION	449859	LLSPSSGyMPMNQSS		molecular association, regulation; phosphorylation		PIK3CB(INDUCES); PIK3R1(INDUCES)		1836	2	2	20	induces phosphorylation of Akt1.	
RSK4	EC 2.7.1.37; EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor)	Q9UK32	27330	RPS6KA6	Xq21	human	S389	PHOSPHORYLATION	457602	HQLFKGFsFVATSIA	Pkinase_C	enzymatic activity, induced				7130	1	4	5		
p70S6K	EC 2.7.11.-; EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor); Translation	Q8BSK8	72508	Rps6kb1		mouse	S447	PHOSPHORYLATION	448357	GSPRTPVsPVKFSPG		molecular association, regulation; enzymatic activity, induced	cell differentiation, altered	DEDD(INDUCES)		7119509; 5011211	90	23	211		
PLK1	EC 2.7.11.21; KINASE; Kinase, protein; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor)	P53350	5347	PLK1	16p12.2	human	T210	PHOSPHORYLATION	448139	YDGERKKtLCGTPNY	Pkinase	molecular association, regulation; enzymatic activity, induced	cell cycle regulation	PLK1(DISRUPTS)		5962; 5273; 1766; 1246; 4338207	15	14	35		
PDX1	DNA binding protein; Transcription factor	P52947	29535	Pdx1		rat	S66	PHOSPHORYLATION	458402	QGSPPDIsPYEVPPL		activity, induced; molecular association, regulation	transcription, induced	p300(INDUCES)		7481	3	0	0		
FOXC2	Apoptosis; Cell development/differentiation; DNA binding protein; Transcription factor	Q99958	2303	FOXC2	16q24.1	human	S288	PHOSPHORYLATION	3210591	SPPGGELsPGAGRAG		molecular association, regulation	transcription, altered		DNA(INDUCES)	28129300	1	4	0	implicated in vascular remodeling  in vivo	
HSF1	DNA binding protein; Transcription factor	Q00613	3297	HSF1	8q24.3	human	S307	PHOSPHORYLATION	449046	EPPSPPQsPRVEEAS	Vert_HS_TF	sumoylation; protein degradation; molecular association, regulation; intracellular localization; activity, inhibited	transcription, induced; transcription, inhibited	14-3-3 epsilon(INDUCES)		25785400; 7324127; 1987906; 3146312; 3027	11	24	3		
GluR KA2	Channel, ligand-gated; Membrane protein, integral; Membrane protein, multi-pass	Q63273	24407	Grik5		rat	S859	PHOSPHORYLATION	27535800	AVSCRKTsRSRRRRR		molecular association, regulation		PSD-95(DISRUPTS)		27519625	1	0	0	 necessary for KAR-LTD; increases expression of KARs at the plasma membrane;  reduced at dendritic spines;  increases lateral mobility of KARs	
calpain 2	EC 3.4.22.53; Motility/polarity/chemotaxis; Protease	P17655	824	CAPN2	1q41-q42	human	T370	PHOSPHORYLATION	451304	GNWRRGStAGGCRNY	Calpain_III	activity, inhibited	cell motility, altered			3527	2	0	0		
DNMT1	Amino Acid Metabolism - cysteine and methionine; Cell development/differentiation; EC 2.1.1.37; Methyltransferase; Methyltransferase, DNA; Transcription regulation	P26358	1786	DNMT1	19p13.2	human	K142	MONO-METHYLATION	17772901	PRTPRRSkSDGEAKP		protein degradation; ubiquitination; phosphorylation				17675034	1	0	0	inhibits S143 phosphorylation	
RelB	Transcription factor	Q04863	19698	Relb		mouse	T84	PHOSPHORYLATION	450232	AAPPPPAtPSWSCTL		protein degradation				1822	1	0	0		
MCM2	DNA binding protein; EC 3.6.4.12	P49736	4171	MCM2	3q21	human	S13	PHOSPHORYLATION	473057	ESFTMASsPAQRRRG		molecular association, regulation	chromatin organization, altered		DNA(INDUCES)	9204	2	13	5	MMCM2 phosphorylated forms are differentially bound to chromatin. 	
PLCG1	Carbohydrate Metabolism - inositol phosphate; EC 3.1.4.11; Motility/polarity/chemotaxis; Phospholipase	P10686	25738	Plcg1		rat	Y783	PHOSPHORYLATION	447667	EGRNPGFyVEANPMP		intracellular localization; enzymatic activity, induced				13796704; 2661901; 760; 6331322	59	25	542		
ataxin-10		Q9UBB4	25814	ATXN10	22q13.31	human	T82	PHOSPHORYLATION	21514208	ASSLQLItECFRCLR	WAPL; Atx10homo_assoc	protein degradation; ubiquitination	cell cycle regulation			21390205	1	1	0	required for cytokinesis	
STAT5A	DNA binding protein; Motility/polarity/chemotaxis; Transcription factor	P42230	20850	Stat5a		mouse	Y694	PHOSPHORYLATION	447767	LAKAVDGyVKPQIKQ		activity, induced	transcription, altered; cell growth, altered		DNA(INDUCES)	2019; 12525207; 5415; 6412; 1906	88	24	2145		
Cx43	Channel, misc.; Membrane protein, integral; Membrane protein, multi-pass; Motility/polarity/chemotaxis	P08050	24392	Gja1		rat	S368	PHOSPHORYLATION	447813	QRPSSRAsSRASSRP		activity, induced; activity, inhibited				8412; 648	17	7	1	gap junction/intercellular communication	
PDE4D iso4	EC 3.1.4.17; Nucleotide Metabolism - purine; Phosphodiesterase	Q08499-4	5144	PDE4D	5q12	human	S490	PHOSPHORYLATION	451090	YQSTIPQsPSPAPDD		enzymatic activity, induced				3199	4	2	0		
Grb10	Adaptor/scaffold	Q13322	2887	GRB10	7p12.2	human	S428	PHOSPHORYLATION	455333	STPVRSVsENSLVAM	BPS	protein stabilization				19044700	2	4	0		
AMPKA2	Autophagy; EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, CAMK; Protein kinase, Ser/Thr (non-receptor)	Q09137	78975	Prkaa2		rat	S491	PHOSPHORYLATION	450432	STPQRSCsAAGLHRP		enzymatic activity, inhibited				2701901	4	7	2		
SSTR2	GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR	P30680		Sstr2		rat	T356	PHOSPHORYLATION	12577701	RLNETTEtQRTLLNG		receptor internalization, altered				12558717	4	0	0		
KHSRP	RNA binding protein	Q92945	8570	KHSRP	19p13.3	human	S274	PHOSPHORYLATION	482097	MILIQDGsQNTNVDK	KH_1	activity, induced; molecular association, regulation				18410826	1	5	4	binds to and functions in pri-miRNA processing	
MYST2	ACETYLTRANSFERASE; Acetyltransferase; EC 2.3.1.48; Nuclear receptor co-regulator; Transcription, coactivator/corepressor	O95251	11143	KAT7	17q21.32	human	S57	PHOSPHORYLATION	460899	SQSSQDSsPVRNLQS			cell cycle regulation			1823400	2	27	52		
PECAM-1	Cell adhesion; Membrane protein, integral	Q08481	18613	Pecam1		mouse	Y679	PHOSPHORYLATION	448759	PQNMDVEyTEVEVSS		molecular association, regulation		SHP-2(INDUCES); SHP-1(INDUCES)		2036	8	0	44	Y679 A.K.A. Y663	
NDUFA1	EC 1.6.5.3; EC 1.6.99.3; Energy Metabolism - oxidative phosphorylation; Membrane protein, integral; Mitochondrial; Oxidoreductase	Q9WU08		NDUFA1		hamster	S55	PHOSPHORYLATION	486441	MERDRRVsGVNRYYV		enzymatic activity, induced				762740	1	1	0	S55 contributes to complex assembly and enzymatic activation.	
Abi-1	Adaptor/scaffold; Motility/polarity/chemotaxis	Q8IZP0	10006	ABI1	10p11.2	human	T394	PHOSPHORYLATION	12626406	ENIADSPtPPPPPPP		molecular association, regulation	cell motility, altered; cytoskeletal reorganization			18668222	1	1	0	regulates WRC (WAVE2 regulatory complex) interaction with Arp2/3 and lamellipodial protrusion	
NCAM1	Cell adhesion; Membrane protein, integral; Motility/polarity/chemotaxis	P13595	17967	Ncam1		mouse	Y734	PHOSPHORYLATION	454070	VVMDITCyFLNKCGL			cell growth, altered			15022713	2	0	0		
Cdc25A	EC 3.1.3.48; Motility/polarity/chemotaxis; PHOSPHATASE; Protein phosphatase, dual-specificity	P30304	993	CDC25A	3p21	human	S178	PHOSPHORYLATION	449126	LFTQRQNsAPARMLS	M-inducer_phosp	protein degradation; molecular association, regulation		14-3-3 beta(INDUCES)		3111; 2163	3	0	0		
NUP153	Nuclear export; Nucleoporin	P49790	9972	NUP153	6p22.3	human	S529	PHOSPHORYLATION	452707	SPMFKFSsPIVKSTE	Nup153	molecular association, regulation		KPNB1(DISRUPTS)		9980430	1	9	0		
POLM	DNA repair; EC 2.7.7.7; Transferase	Q9NP87	27434	POLM	7p13	human	S12	PHOSPHORYLATION	469477	RRRARVGsPSGDAAS		molecular association, regulation; enzymatic activity, inhibited			DNA(DISRUPTS)	28723104	1	7	5		
MC1R	GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR	Q01726	4157	MC1R	16q24.3	human	T157	PHOSPHORYLATION	8051400	LRYHSIVtLPRARRA	7tm_1		exocytosis, altered			7910516	1	0	1	rescues the retention phenotype of R160W and R162P	
KCNE1	Channel, potassium; Membrane protein, integral	P15383	25471	Kcne1		rat	S103	PHOSPHORYLATION	10349700	FQARVLEsFRACYVI	ISK_Channel	activity, inhibited				10144231	2	0	0		
OSR1	EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, STE; Protein kinase, Ser/Thr (non-receptor)	O95747	9943	OXSR1	3p22.2	human	T185	PHOSPHORYLATION	456503	TRNKVRKtFVGTPCW	Pkinase	enzymatic activity, induced				2195492; 2653903; 6710	6	4	36		
BRAF	EC 2.7.1.37; EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, Ser/Thr (non-receptor); Protein kinase, TKL	F1M9C3	114486	Braf		rat	S347	PHOSPHORYLATION	450243	GQRDRSSsAPNVHIN		molecular association, regulation; enzymatic activity, inhibited	cell growth, altered	14-3-3 beta(INDUCES)		9001	7	14	30	stimulates cell proliferation	
FRA1	DNA binding protein; Transcription factor	P15407	8061	FOSL1	11q13	human	S252	PHOSPHORYLATION	478351	ASAHRKSsSSSGDPS		protein stabilization				9581	3	0	3		
NPM1	RNA binding protein; Translation	P06748	4869	NPM1	5q35.1	human	S70	PHOSPHORYLATION	459898	EAMNYEGsPIKVTLA	Nucleoplasmin	molecular association, regulation; intracellular localization; phosphorylation	cell cycle regulation	Cdc25C(INDUCES)		11424230	4	44	27	mutation of S10/S70 to alanine increases CDK1 Y15 phosphorylation;  mutation of S10/70 to glutamate decreases Cdc25C S216 phosphorylation	
ANPA	EC 4.6.1.2; Guanylyl cyclase; KINASE; Kinase, protein; Lyase; Membrane protein, integral; Nucleotide Metabolism - purine; Protein kinase, RGC; Protein kinase, dual-specificity; Receptor, misc.	P16066	4881	NPR1	1q21-q22	human	S538	PHOSPHORYLATION	447515	LTLSGRGsNYGSLLT		activity, induced				896	2	2	0		
GABRB2	Channel, chloride; Channel, ligand-gated; Membrane protein, integral; Membrane protein, multi-pass	P47870	2561	GABRB2	5q34	human	T389	PHOSPHORYLATION	10769102	LSPTRRTtNYDFSLY	Neur_chan_memb	activity, inhibited				10353929	1	0	0	channel current run-down is reduced in T389A mutant receptor;  i.e., phosphorylation may contribute to channel inhibition	
Btk	EC 2.7.10.2; KINASE; Kinase, protein; Protein kinase, TK; Protein kinase, tyrosine (non-receptor)	P35991	12229	Btk		mouse	Y375	PHOSPHORYLATION	457681	GLISRLKyPVSKQNK		not reported				7291	1	2	20	mutation of site in transfection assays or knock-in mice had no significant effect on biological function.	
Kv2.1	Channel, cation; Channel, ligand-gated; Channel, potassium; Membrane protein, integral; Membrane protein, multi-pass	P15387	25736	Kcnb1		rat	S457	PHOSPHORYLATION	473558	MKDAFARsIEMMDIV		activity, inhibited				9216	2	5	0		
4E-BP1	Translation; Translation initiation	Q62622	116636	Eif4ebp1		rat	T36	PHOSPHORYLATION	447497	PPGDYSTtPGGTLFS	eIF_4EBP	molecular association, regulation; phosphorylation	translation, altered	eIF4E(DISRUPTS)		15658714; 6650; 842	89	24	87		
NPM1	RNA binding protein; Translation	P06748	4869	NPM1	5q35.1	human	K230	ACETYLATION	6216434	KGQESFKkQEKTPKT	Nop14; TFIIF_alpha	molecular association, regulation; intracellular localization	transcription, altered	H3(INDUCES)		8156707	1	1	4	K212/215/229/230/257/267/292R  mutant	
NFAT5	Transcription factor	O94916	10725	NFAT5	16q22.1	human	S155	PHOSPHORYLATION	2715402	PEDLLDNsRMSCQDE		intracellular localization				2704322; 18021001	3	3	2		
GTF2I iso2	DNA binding protein; Transcription, coactivator/corepressor	P78347-2	2969	GTF2I	7q11.23	human	S627	PHOSPHORYLATION	452349	INTKALQsPKRPRSP			transcription, altered			8845	1	7	5		
K17	Cytoskeletal protein	Q9QWL7	16667	Krt17		mouse	S44	PHOSPHORYLATION	464291	AGSCRLGsASGLGSA		molecular association, regulation	cell cycle regulation	14-3-3 sigma(NOT_REPORTED)		7892	2	0	0	Mutation of T8 and S43 (to alanine) causes reduced phosphorylation of Akt S473 and p70S6K T389.	
PGC-1 alpha	Nuclear receptor co-regulator; Transcription, coactivator/corepressor	Q9QYK2		Ppargc1a		rat	S569	PHOSPHORYLATION	2045307	RMRSRSRsFSRHRSC		acetylation; activity, inhibited	transcription, altered			11387282	3	0	0		
PAK1	EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, STE; Protein kinase, Ser/Thr (non-receptor)	Q13153	5058	PAK1	11q13-q14	human	T109	PHOSPHORYLATION	14150103	QWARLLQtSNITKSE	PBD	enzymatic activity, inhibited				14058612	1	1	0	in vitro	
NKG2A	Membrane protein, integral; Receptor, misc.	P26715	3821	KLRC1	12p13	human	Y40	PHOSPHORYLATION	455556	ATEQEITyAELNLQK		activity, induced; molecular association, regulation; intracellular localization		SHP-1(INDUCES)		5439	1	0	0		
Casp8	Apoptosis; EC 3.4.22.-; EC 3.4.22.61; Protease	Q14790	841	CASP8	2q33-q34	human	S387	PHOSPHORYLATION	16855100	YLEMDLSsPQTRYIP	Peptidase_C14	protein processing; intracellular localization; enzymatic activity, inhibited	apoptosis, altered; carcinogenesis, altered			15754903	2	0	0		
IGFBP3	Cell development/differentiation; Secreted; Secreted, signal peptide	P17936	3486	IGFBP3	7p13-p12	human	S140	PHOSPHORYLATION	451463	APGNASEsEEDRSAG			apoptosis, induced			8567	2	0	0		
RIMS1 iso7	Adaptor/scaffold; Vesicle protein	Q99NE5-7	116837	Rims1		mouse	S413	PHOSPHORYLATION	450481	ARHERRHsDVALPHT		molecular association, regulation		14-3-3 epsilon(INDUCES)		4641426	3	4	0		
HuR	RNA binding protein	Q15717	1994	ELAVL1	19p13.2	human	S318	PHOSPHORYLATION	2246702	GDKILQVsFKTNKSH		molecular association, regulation; intracellular localization	cell cycle regulation; carcinogenesis, altered; cell motility, altered	14-3-3 theta(INDUCES)	RNA(INDUCES); RNA(NOT_REPORTED)	28723110; 2195481; 12525216; 18415107	6	1	0	increases cell migration and proliferation	
MDC1	Cell cycle regulation	Q14676	9656	MDC1	6p21.3	human	T404	PHOSPHORYLATION	3196400	SMVINSDtDDEEEVS		molecular association, regulation	cell cycle regulation	NBS1(INDUCES)		4042508	1	11	7	MDC1-NBS1 interaction regulates intra-S-phase checkpoint activation	
SIT	Adaptor/scaffold; Membrane protein, integral	Q9Y3P8	27240	SIT1	9p13-p12	human	Y188	PHOSPHORYLATION	448962	ASFPDQAyANSQPAA		molecular association, regulation		Grb2(INDUCES)		12668809	1	5	202	Y90 is major binding site.	
RORA iso4	DNA binding protein; Nuclear receptor	P35398-4	6095	RORA	15q22.2	human	T128	PHOSPHORYLATION	482887	PGEAEPLtPTYNISA		activity, inhibited	transcription, inhibited		DNA(DISRUPTS)	11811	1	0	0		
ACP1	Cofactor and Vitamin Metabolism - riboflavin; EC 3.1.3.2; EC 3.1.3.48; Motility/polarity/chemotaxis; PHOSPHATASE; Phosphatase (non-protein); Protein phosphatase, tyrosine (non-receptor)	Q3SZ94	280977	ACP1		cow	Y133	PHOSPHORYLATION	457445	LIIEDPYyGNDADFE	LMWPc	molecular association, regulation		Grb2(INDUCES)		7083	5	6	87		
FAK iso3	EC 2.7.1.112; EC 2.7.10.2; KINASE; Kinase, protein; Protein kinase, TK; Protein kinase, tyrosine (non-receptor)	P34152-3	14083	Ptk2		mouse	S910	PHOSPHORYLATION	447964	KLQPQEIsPPPTANL		molecular association, regulation		PXN(DISRUPTS)		2085	16	26	0		
ZAK	EC 2.7.11.25; KINASE; Kinase, protein; Protein kinase, Ser/Thr (non-receptor); Protein kinase, TKL	Q9NYL2	51776	ZAK	2q24.2	human	S165	PHOSPHORYLATION	455379	HNHTTHMsLVGTFPW	Pkinase_Tyr	enzymatic activity, induced				4622	1	0	0		
MCL1	Apoptosis; Channel, misc.; Inhibitor protein; Membrane protein, integral; Mitochondrial	P97287	17210	Mcl1		mouse	T144	PHOSPHORYLATION	455375	ADGSLPStPPPPEEE		protein stabilization; molecular association, regulation		Pin1(INDUCES)		1163003	7	11	8		
FLT3	EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Protein kinase, TK; Protein kinase, tyrosine (receptor)	Q00342	14255	Flt3		mouse	Y922	PHOSPHORYLATION	456470	FYATEGIyFVMQSCW	Pkinase_Tyr	protein stabilization; enzymatic activity, induced				6717	1	0	0		
TORC2	Transcription, coactivator/corepressor	Q8BH09	74343	Crtc2		mouse	S171	PHOSPHORYLATION	454622	SALNRTSsDSALHTS	TORC_M	protein degradation; molecular association, regulation; enzymatic activity, inhibited; intracellular localization; activity, inhibited	signaling pathway regulation; transcription, altered	14-3-3 beta(INDUCES); COP1(NOT_REPORTED)		12482291; 7550813; 6337804; 3173900; 4316; 14784602; 12291	12	4	8		
RARA	DNA binding protein; Nuclear receptor; Transcription factor	P10276	5914	RARA	17q21	human	S219	PHOSPHORYLATION	13373501	NSSEQRVsLDIDLWD	Hormone_recep	molecular association, regulation; intracellular localization; activity, inhibited	transcription, inhibited	RXRA(DISRUPTS)		13359102	1	0	0		
BAD	Apoptosis	Q92934	572	BAD	11q13.1	human	T137	PHOSPHORYLATION	1904506	PRPKSAGtATQMRQS	Bcl-2_BAD	activity, induced				4646603	2	0	0		
Kv4.2	Channel, potassium; Membrane protein, integral; Membrane protein, multi-pass	Q63881		Kcnd2		rat	S552	PHOSPHORYLATION	450462	VSGSHRGsVQELSTI		intracellular localization				3309501; 12482255	5	7	0	important for Kv4.2 internalization in hippocampal neurons; S552 phosphorylation occurs in response to plasma membrane localization.	
SIRT2	DEACETYLASE; Deacetylase; EC 3.5.1.-	Q8IXJ6	22933	SIRT2	19q13	human	S372	PHOSPHORYLATION	482810	TSASPKKsPPPAKDE		enzymatic activity, induced				11816	1	10	1	enzymatic activity of mutant S368A/S372A (but not S386A) was reduced 44%	
Chk2	EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, CAMK; Protein kinase, Ser/Thr (non-receptor)	O96017	11200	CHEK2	22q12.1	human	S35	PHOSPHORYLATION	447550	SQGSSSQsQGISSSS	DUF966	molecular association, regulation; enzymatic activity, induced	cell cycle regulation	Chk2(INDUCES); PPP2CA(DISRUPTS)		13852010; 12176	9	1	0	S19A mutant shows impaired dimerization and does not promote Hdmx degradation	
VAV1	Guanine nucleotide exchange factor, Rac/Rho; Motility/polarity/chemotaxis	P15498	7409	VAV1	19p13.2	human	Y841	PHOSPHORYLATION	464357	ANYVEEDySEYC___		activity, induced; molecular association, regulation	carcinogenesis, altered; cell growth, altered	Src(INDUCES); SH2-B-beta(INDUCES); PLCG1(INDUCES); Brk(INDUCES)		14551403	1	0	58		
ETV1	DNA binding protein; Transcription factor	P50549	2115	ETV1	7p21.3	human	S146	PHOSPHORYLATION	3059603	TPSSTPVsPLHHASP	ETS_PEA3_N	activity, induced	transcription, induced			8495	2	0	0		
FLT3	EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Protein kinase, TK; Protein kinase, tyrosine (receptor)	P36888	2322	FLT3	13q12	human	Y842	PHOSPHORYLATION	454872	DIMSDSNyVVRGNAR	Pkinase_Tyr	protein conformation; phosphorylation	apoptosis, inhibited; cell growth, altered			4446	5	1	76	FLT3 Y842C -transfected cells show constitutive FLT3 tyrosine phosphorylation and activation 	
VEGFR3	EC 2.7.1.112; EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Protein kinase, TK; Protein kinase, tyrosine (receptor)	P35916	2324	FLT4	5q35.3	human	Y1231	PHOSPHORYLATION	4119681	HSLAARYyNWVSFPG		molecular association, regulation; enzymatic activity, induced	cell motility, induced; cell growth, induced	Grb2(INDUCES)		25699200	2	0	1		
eIF3-epsilon	EC 3.4.19.12; Translation; Translation initiation	O00303	8665	EIF3F	11p15.4	human	S46	PHOSPHORYLATION	448818	PAAAPASsSDPAAAA			transcription, altered			1993	2	1	0		
PPAR-alpha	DNA binding protein; Nuclear receptor	P37230	25747	Ppara		rat	S142	PHOSPHORYLATION	457550	AYDKCDRsCKIQKKN	zf-C4	activity, induced	transcription, altered			7128	1	0	0		
CD45	EC 3.1.3.48; Membrane protein, integral; Motility/polarity/chemotaxis; PHOSPHATASE; Receptor protein phosphatase, tyrosine	P06800	19264	Ptprc		mouse	S992	PHOSPHORYLATION	449974	EPESDESsDDDSDSE	Y_phosphatase	enzymatic activity, induced				2533	1	4	0		
syndecan-4	Cell adhesion; Membrane protein, integral; Motility/polarity/chemotaxis	P31431	6385	SDC4	20q12	human	S179	PHOSPHORYLATION	449863	MKKKDEGsYDLGKKP	Syndecan; Glycophorin_A; Herpes_gE	molecular association, regulation; protein processing; intracellular localization	cell cycle regulation; cytoskeletal reorganization; cell adhesion, altered	syndecan-4(DISRUPTS)	Other(DISRUPTS)	3926; 13359101; 2411	6	0	0	 binding to lipid increases PKCalpha activation; S179A mutant abrogates protein shedding ; other = PIP2 binding; decreases PtdIns(4,5)P2 lipid binding	
PPAR-gamma iso2	DNA binding protein; Nuclear receptor	P37238-2	19016	Pparg		mouse	S16	PHOSPHORYLATION	12170300	WPTNFGIsSVDLSVM	PPARgamma_N	intracellular localization	transcription, altered			12021331	1	0	0		
ataxin-1	RNA binding protein	P54253	6310	ATXN1	6p23	human	S775	PHOSPHORYLATION	449110	ATRKRRWsAPESRKL		protein degradation; protein stabilization; molecular association, regulation; intracellular localization	cytoskeletal reorganization	14-3-3 beta(INDUCES); 14-3-3 zeta(INDUCES); 14-3-3 epsilon(INDUCES)		2145; 2150; 11996	11	15	3	ataxin-1 S776A mutant reduces nuclear inclusion bodies of ataxin-1 in B05 tg/+ mice.	
XRCC1	DNA repair	P18887	7515	XRCC1	19q13.2	human	S518	PHOSPHORYLATION	451449	GEDPYAGsTDENTDS		molecular association, regulation; intracellular localization		APTX(INDUCES); Pnk1(INDUCES)		3651; 8895	2	3	6		
E2F5	DNA binding protein; Transcription factor	Q61502	13559	E2f5		mouse	T251	PHOSPHORYLATION	448010	SQSSTSVtPQKSTMA		molecular association, regulation	cell cycle regulation; transcription, induced	p300(INDUCES)		1688	1	1	1		
IL-8R B	GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR; Receptor, cytokine	P25025	3579	CXCR2	2q35	human	S352	PHOSPHORYLATION	451048	RPSFVGSsSGHTSTT		protein degradation; receptor desensitization, altered; receptor internalization, altered				3279	1	0	1		
CTNNB1	Actin binding protein; Cell adhesion; Motility/polarity/chemotaxis; Nuclear receptor co-regulator; Transcription factor	Q02248	12387	Ctnnb1		mouse	Y142	PHOSPHORYLATION	449044	AVVNLINyQDDAELA	HEAT_2; RIX1	molecular association, regulation	cell adhesion, altered	CTNNA1(DISRUPTS)		2078	8	1	0		
CACNA1D	Channel, calcium; Membrane protein, integral; Membrane protein, multi-pass	P27732	29716	Cacna1d		rat	S1534	PHOSPHORYLATION	465731	DEFKRIWsEYDPEAK		activity, induced				8072	1	0	0	required for IGF-1 induced channel potentiation 	
SLAM	Membrane protein, integral; Receptor, misc.	Q13291	6504	SLAMF1	1q23.3	human	Y327	PHOSPHORYLATION	447634	ETNSITVyASVTLPE		molecular association, regulation		SHP-2(INDUCES); SH2D1A(INDUCES); APCS(INDUCES)		4119; 1383	3	0	0		
NEDD1	Cell cycle regulation	Q8NHV4	121441	NEDD1	12q23.1	human	T382	PHOSPHORYLATION	9379001	PRSINTDtLSKETDS		molecular association, regulation	cell cycle regulation			9201031	1	1	0	important for binding of NEDD1 with gamma-tubulin	
INCA1		Q0VD86	388324	INCA1	17p13.2	human	S191	PHOSPHORYLATION	12524603	GRAQLLWsPWSPLDQ	ELM2	molecular association, regulation		CCNA1(INDUCES); CCNA2(INDUCES)		12482288	1	0	0	Cyclin A1-CDK2 or Cyclin  A2-CDK2 complex	
neurogenin 2	Transcription factor	P70447	11924	Neurog2		mouse	S234	PHOSPHORYLATION	2255100	SCTLSPAsPGSDVDY		molecular association, regulation	cell growth, altered	LDB1(INDUCES)		2704319	2	0	0	important for spinal motor neuron differentiation	
KARS	EC 6.1.1.6; Ligase; Mitochondrial; Translation	Q15046	3735	KARS	16q23.1	human	S207	PHOSPHORYLATION	9392600	PYEITLLsPCLHMLP		intracellular localization; enzymatic activity, induced				9160400	1	0	0		
BAD	Apoptosis	Q92934	572	BAD	11q13.1	human	S74	PHOSPHORYLATION	5209400	VEIRSRHsSYPAGTE	Bcl-2_BAD	molecular association, regulation; phosphorylation		Bcl-2(DISRUPTS)		22463919	1	5	65	mutation of this site to Ala reduces S75 phosphorylation	
MDC1	Cell cycle regulation	Q14676	9656	MDC1	6p21.3	human	S453	PHOSPHORYLATION	453670	QTTTERDsDTDVEEE		molecular association, regulation	cell cycle regulation	NBS1(INDUCES)		4042508	1	15	98	MDC1-NBS1 interaction regulates intra-S-phase checkpoint activation	
H3 iso3	DNA binding protein	P84244	15081	H3f3b		mouse	S11	PHOSPHORYLATION	455676	TKQTARKsTGGKAPR		activity, induced; molecular association, regulation	transcription, induced; transcription, altered; cell growth, altered	HP1 alpha(INDUCES)		6799; 4658; 5557; 5621	167	5	1		
IRSp53	Actin binding protein; Motility/polarity/chemotaxis	Q9UQB8	10458	BAIAP2	17q25	human	T360	PHOSPHORYLATION	4751846	YATTENKtLPRSSSM		molecular association, regulation	cytoskeletal reorganization	14-3-3 zeta(INDUCES)		11419368	1	5	13		
DDX58	EC 3.6.1.-; EC 3.6.4.13; Hydrolase	O95786	23586	DDX58	9p12	human	K172	UBIQUITINATION	486285	ENWPKTLkLALEKER		ubiquitination				27132411	5	0	0		
NCBP1	RNA processing; Spliceosome; Translation	Q09161	4686	NCBP1	9q34.1	human	S22	PHOSPHORYLATION	1219020	PHKRRKTsDANETED			RNA splicing, altered			12482263	1	19	25		
FLNA	Actin binding protein; Motility/polarity/chemotaxis; Nuclear receptor co-regulator	P21333	2316	FLNA	Xq28	human	S2152	PHOSPHORYLATION	451357	TRRRRAPsVANVGSH	Filamin	protein stabilization	cytoskeletal reorganization			4910500; 3564; 8202	10	40	934		
CNR2	GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR	P34972	1269	CNR2	1p36.11	human	S352	PHOSPHORYLATION	450818	KITPWPDsRDLDLSD		receptor desensitization, altered				3141	1	0	0		
Fer	EC 2.7.10.2; KINASE; Kinase, protein; Protein kinase, TK; Protein kinase, tyrosine (non-receptor)	P70451	14158	Fer		mouse	Y715	PHOSPHORYLATION	448461	RQEDGGVySSSGLKQ	Pkinase_Tyr		cell cycle regulation; cell motility, altered			2790302	2	23	639		
phosducin	G protein regulator, misc.	P20942	25343	Pdc		rat	S54	PHOSPHORYLATION	454888	KEILRQMsSPQSRDD	Phosducin; SPK	molecular association, regulation; protein conformation		GNB1(DISRUPTS); 14-3-3 zeta(INDUCES); G-gamma(2)(DISRUPTS)		10144212; 27258203	5	1	1	Phosphorylation at S54 and S73 induce a structural change in the whole phosducin molecule in complex formation with 14-3-3. 	
DNER	Membrane protein, integral; Receptor, misc.	Q8NFT8	92737	DNER	2q36.3	human	Y718	PHOSPHORYLATION	473324	YDVSPIAyEDYSPDD		intracellular localization				2831768	1	2	4		
TNNI3	Actin binding protein; Motility/polarity/chemotaxis; Motor protein	P48787	21954	Tnni3		mouse	S23	PHOSPHORYLATION	448423	PAPVRRRsSANYRAY	Troponin-I_N	activity, induced; protein conformation; activity, inhibited; phosphorylation	cytoskeletal reorganization			13320406; 7134; 3342610; 854; 4862629; 8954; 4423	37	4	11		
ephexin-5	Guanine nucleotide exchange factor, Rac/Rho	Q5FWH6	442801	Arhgef15		mouse	Y361	PHOSPHORYLATION	17790901	PLQDEPLyQTYRAAV		protein degradation; ubiquitination				17722105	1	0	0		
Abi-1	Adaptor/scaffold; Motility/polarity/chemotaxis	Q8IZP0	10006	ABI1	10p11.2	human	S392	PHOSPHORYLATION	12626405	VQENIADsPTPPPPP		molecular association, regulation	cell motility, altered; cytoskeletal reorganization			18668222	1	1	0	regulates WRC (WAVE2 regulatory complex) interaction with Arp2/3 and lamellipodial protrusion	
SCN2A	Channel, sodium; Membrane protein, integral; Membrane protein, multi-pass	P04775	24766	Scn2a		rat	S1112	PHOSPHORYLATION	6003508	VPIALGEsDFENLNT	Na_trans_assoc	intracellular localization				5930021	1	0	0	regulates SCN2A accumulation at the axonal initial segment (AIS) and interaction with ankyrin G	
VEGFR3	EC 2.7.1.112; EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Protein kinase, TK; Protein kinase, tyrosine (receptor)	P35916	2324	FLT4	5q35.3	human	Y1230	PHOSPHORYLATION	4119675	RHSLAARyYNWVSFP		molecular association, regulation; enzymatic activity, induced	cell motility, induced; cell growth, induced	Grb2(INDUCES)		25699200	2	0	1		
GRK2	EC 2.7.11.15; KINASE; Kinase, protein; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor)	P25098	156	ADRBK1	11q13.1	human	S685	PHOSPHORYLATION	447726	VPLVQRGsANGL___		molecular association, regulation		G-alpha(q)(INDUCES)		8243	2	4	1		
TREK-2	Channel, potassium; Membrane protein, integral; Membrane protein, multi-pass	Q9JIS4	65272	Kcnk10		rat	S359	PHOSPHORYLATION	465530	RETRRRLsVEIHDKL		activity, inhibited				7974; 11820	2	1	0	relative channel activity reduced in S326D and S359D mutants;  shift of gating modes; inhibition mediated by ACh	
CTNNB1	Actin binding protein; Cell adhesion; Motility/polarity/chemotaxis; Nuclear receptor co-regulator; Transcription factor	P35222	1499	CTNNB1	3p21	human	Y489	PHOSPHORYLATION	462002	QNAVRLHyGLPVVVK		molecular association, regulation; intracellular localization	transcription, induced	LEF-1(INDUCES); CDH2(DISRUPTS)		12064	1	7	80		
INCENP	Cell cycle regulation; EC 2.7.11.1	Q9NQS7	3619	INCENP	11q12.3	human	T892	PHOSPHORYLATION	450466	KPRYHKRtSSAVWNS		activity, induced				3012	1	5	3		
Mer	EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Protein kinase, TK; Protein kinase, tyrosine (receptor)	Q60805	17289	Mertk		mouse	Y867	PHOSPHORYLATION	1319200	QDKESIIyINTQLLE		phosphorylation	exocytosis, altered			1172858	1	0	0	regulates phagocytosis and Y861 phosphorylation  of FAK, and Akt activation	
NMDAR2B	Channel, calcium; Channel, ligand-gated; Membrane protein, integral; Membrane protein, multi-pass	Q00960	24410	Grin2b		rat	Y1472	PHOSPHORYLATION	448167	GSSNGHVyEKLSSIE	NMDAR2_C	molecular association, regulation		PSD-95(INDUCES)		2512008	20	0	102		
PTEN	Carbohydrate Metabolism - inositol phosphate; EC 3.1.3.16; EC 3.1.3.48; EC 3.1.3.67; Motility/polarity/chemotaxis; Nuclear receptor co-regulator; PHOSPHATASE; Phosphatase, lipid; Tumor suppressor	P60484	5728	PTEN	10q23.3	human	Y336	PHOSPHORYLATION	7596704	NKDKANRyFSPNFKV	PTEN_C2	protein stabilization; molecular association, regulation		NEDD4 iso4(DISRUPTS)		7543527	1	0	0		
NR1I3	DNA binding protein; Nuclear receptor	Q14994	9970	NR1I3	1q23.3	human	T38	PHOSPHORYLATION	11281700	CKGFFRRtVSKSIGP	Prok-RING_2; zf-C4; YdjO	molecular association, regulation; intracellular localization; protein conformation; activity, inhibited			DNA(DISRUPTS)	11189919	4	0	0		
Cx43	Channel, misc.; Membrane protein, integral; Membrane protein, multi-pass; Motility/polarity/chemotaxis	P17302	2697	GJA1	6q22.31	human	S279	PHOSPHORYLATION	448853	SSPTAPLsPMSPPGY		protein degradation; intracellular localization	cytoskeletal reorganization			7835; 1172869	17	1	0	UV-induced phosphorylation inhibits gap junctional intercellular communication	
BRAF	EC 2.7.1.37; EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, Ser/Thr (non-receptor); Protein kinase, TKL	P15056	673	BRAF	7q34	human	S750	PHOSPHORYLATION	2192591	FSLYACAsPKTPIQA		molecular association, regulation	cell growth, altered	RAF1(DISRUPTS)		12025500	1	6	1		
tau iso8	Cytoskeletal protein	P10636-8	4137	MAPT	17q21.1	human	T175	PHOSPHORYLATION	449077	ATRIPAKtPPAPKTP			apoptosis, induced; cytoskeletal reorganization	TUBB1(DISRUPTS)		7483315	5	5	0	T175 phosphorylation induced increased fibril formation and cell death.	
RGS7	GTPase activating protein, RGS	P49802	6000	RGS7	1q43|1q23.1	human	S434	PHOSPHORYLATION	455540	YKLMKSDsYPRFIRS	RGS	molecular association, regulation		14-3-3 beta(DISRUPTS)		5419	1	0	0		
TrkA	EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Protein kinase, TK; Protein kinase, tyrosine (receptor)	P35739	59109	Ntrk1		rat	Y684	PHOSPHORYLATION	447764	DIYSTDYyRVGGRTM	Pkinase_Tyr	molecular association, regulation; enzymatic activity, induced	cell cycle regulation; cytoskeletal reorganization; cell growth, altered	DNAJA3(INDUCES)		6193; 5205; 5955615	9	1	8	neurite outgrowth;  acidic substitution of Y683, Y684 is constitutively active.	
KCC2	Membrane protein, integral; Membrane protein, multi-pass; Transporter	Q9H2X9	57468	SLC12A5	20q13.12	human	T1030	PHOSPHORYLATION	10045602	DPEKVHLtWTKDKSV		activity, inhibited				9985929	1	4	1		
GLP1R	GPCR, family 2; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR	P32301	25051	Glp1r		rat	S445	PHOSPHORYLATION	451383	CPTSSVSsGATVGSS		receptor desensitization, altered				3574	1	0	0		
CACNA1B	Channel, calcium; Membrane protein, integral; Membrane protein, multi-pass	Q05152	100008979	CACNA1B		rabbit	S447	PHOSPHORYLATION	459048	TGLCAPGsPFARASL		activity, induced				7447	1	1	4		
syndecan-1	Extracellular matrix; Membrane protein, integral; Motility/polarity/chemotaxis	P18827	6382	SDC1	2p24.1	human	Y309	PHOSPHORYLATION	455075	PTKQEEFyA______		molecular association, regulation	cytoskeletal reorganization; cell adhesion, altered	syntenin(DISRUPTS)		7889914	1	6	152	required for LG4/5-induced microspikes	
PYGM	Carbohydrate Metabolism - starch and sucrose; EC 2.4.1.1; Endoplasmic reticulum; Phosphorylase; Transferase	P11217	5837	PYGM	11q12-q13.2	human	S15	PHOSPHORYLATION	449838	QEKRKQIsVRGLAGV		protein conformation; enzymatic activity, induced				12482230	4	4	0	14 residue phosphopeptide with phosphorylated S14, PYGM becomes activated in the absence of AMP and associates to a tetramer. 	
Wee1	EC 2.7.10.2; KINASE; Kinase, protein; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor)	P30291	7465	WEE1	11p15.3-p15.1	human	T239	PHOSPHORYLATION	11311200	QVNINPFtPDSLLLH			cell cycle regulation			11189920	1	0	0		
ATM	EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, ATYPICAL; Protein kinase, Ser/Thr (non-receptor)	Q13315	472	ATM	11q22-q23	human	S1981	PHOSPHORYLATION	448797	SLAFEEGsQSTTISS		activity, induced; protein stabilization; molecular association, regulation; intracellular localization; enzymatic activity, induced	cell cycle regulation; apoptosis, altered; chromatin organization, altered	ATM(INDUCES); MDC1(INDUCES); p53(INDUCES); NBS1(INDUCES); CDCA2(DISRUPTS)		3957; 1958; 22463922; 4526; 7890; 5470; 15023500; 4313623; 1970901; 4313607; 1173004; 6702307; 12482405; 15331031; 14148605; 12735100; 3577; 7214800	128	11	4	ATM induces P38 activation and p53 S46 phosphorylation dependent apoptosis.; ATM autophosphorylation  site	
GR	DNA binding protein; Mitochondrial; Nuclear receptor; Transcription factor	P06536	24413	Nr3c1		rat	T171	PHOSPHORYLATION	451795	TSATGCAtPTEKEFP	GCR		transcription, inhibited			7991139	6	5	0		
RhoGDI alpha	Apoptosis; Cell adhesion; Cell development/differentiation; G protein regulator, misc.; Motility/polarity/chemotaxis	P52565	396	ARHGDIA	17q25.3	human	Y156	PHOSPHORYLATION	469606	YGPRAEEyEFLTPVE	Rho_GDI	molecular association, regulation; intracellular localization		RAC1(DISRUPTS); RhoA(DISRUPTS); Cdc42 iso1(DISRUPTS)		8279; 12021318	2	1	19		
14-3-3 beta	Adaptor/scaffold	P35213	56011	Ywhab		rat	S60	PHOSPHORYLATION	450226	VVGARRSsWRVISSI	14-3-3; BLOC1_2; FliM; DUF4303	intracellular localization	transcription, altered			8213	5	0	10	Double mutant inhibited a MEF2 reporter and promotes nuclear localization  of HDAC4/GFP.	
vimentin	Cytoskeletal protein; Motility/polarity/chemotaxis	P20152	22352	Vim		mouse	S66	PHOSPHORYLATION	451765	GAYVTRSsAVRLRSS	Filament_head; DUF2464		cytoskeletal reorganization			2057	5	5	17		
Myc	DNA binding protein; Transcription factor	P01106	4609	MYC	8q24.21	human	S62	PHOSPHORYLATION	448586	LLPTPPLsPSRRSGL	Myc_N	activity, induced; O-GlcNAc glycosylation; protein degradation; protein stabilization; molecular association, regulation; phosphorylation	apoptosis, altered; apoptosis, induced; transcription, induced; transcription, altered; cell growth, altered	FBXW7(INDUCES); axin 1(INDUCES); PPP2R5A(NOT_REPORTED); Pin1(INDUCES)	DNA(INDUCES)	643; 1919603; 3689; 4625; 4749; 3398504; 27519641; 13788312; 1969114; 4966801; 6460; 7124707; 2540; 13796703; 4260502	33	12	28		
PAK1	EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, STE; Protein kinase, Ser/Thr (non-receptor)	P35465	29431	Pak1		rat	T211	PHOSPHORYLATION	448176	VIEPLPVtPTRDVAT		intracellular localization	cytoskeletal reorganization			5011219	9	15	17	during mitosis	
CEP55	Cancer Testis Antigen (CTA); Cell cycle regulation	Q53EZ4	55165	CEP55	10q23.33	human	S428	PHOSPHORYLATION	457629	KVAASPKsPTAALNE		activity, induced; molecular association, regulation	cell cycle regulation	PLK1(INDUCES)		7205	1	17	11		
p47phox	EC 1.-.-.-; Oxidoreductase	P14598	653361	NCF1	7q11.23	human	S328	PHOSPHORYLATION	449404	QDAYRRNsVRFLQQR		molecular association, regulation; enzymatic activity, induced		CYBA(INDUCES); ACTB(INDUCES)		2208; 7367; 8704	10	0	0		
Met	EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Protein kinase, TK; Protein kinase, tyrosine (receptor)	P08581	4233	MET	7q31	human	Y1234	PHOSPHORYLATION	448470	RDMYDKEyYSVHNKT	Pkinase_Tyr	activity, induced; protein conformation; phosphorylation; enzymatic activity, induced	cell motility, altered; cell growth, altered	PTP1B(INDUCES); PTPN2(INDUCES); Grb2(INDUCES)		2838; 1169; 21261103; 6115921; 2852648; 5544	35	21	702		
CAMK2A	EC 2.7.11.17; KINASE; Kinase, protein; Protein kinase, CAMK; Protein kinase, Ser/Thr (non-receptor)	Q9UQM7	815	CAMK2A	5q32	human	T305	PHOSPHORYLATION	448802	KLKGAILtTMLATRN		intracellular localization				3249408	18	3	0		
CD45	EC 3.1.3.48; Membrane protein, integral; Motility/polarity/chemotaxis; PHOSPHATASE; Receptor protein phosphatase, tyrosine	P06800	19264	Ptprc		mouse	S996	PHOSPHORYLATION	449975	DESSDDDsDSEETSK	Y_phosphatase	enzymatic activity, induced				2533	1	2	0		
CTNND2	Actin binding protein; Motility/polarity/chemotaxis	O35927	18163	Ctnnd2		mouse	Y1176	PHOSPHORYLATION	461085	QEPSRKDyETYQPFP			cell cycle regulation; cell motility, altered			2790302	0	1	5		
HMGN1	DNA binding protein	P05114	3150	HMGN1	21q22.2	human	S25	PHOSPHORYLATION	454112	KRRSARLsAKPPAKV	HMG14_17	molecular association, regulation; intracellular localization		14-3-3 zeta(INDUCES)		8551; 5441	5	5	0	Phosphorylation facilitates localization to non-nuclear pools.	
GPSM2	G protein regulator, misc.	P81274	29899	GPSM2	1p13.3	human	T457	PHOSPHORYLATION	18412000	LKGKKYKtNSSTKVL			cell cycle regulation; cell growth, altered			15785000	1	0	0	plays a critical role in cytokinesis	
LLGL1	Cell adhesion; Cytoskeletal protein; Motility/polarity/chemotaxis	NP_032528	16897	Llgl1		mouse	S654	PHOSPHORYLATION	449915	GPLSRVKsLKKSLRQ		intracellular localization				2469	1	0	4		
USP8	EC 3.1.2.15; EC 3.4.19.12; Protease; Ubiquitin conjugating system; Ubiquitin-specific protease	Q80U87	84092	Usp8		mouse	S680	PHOSPHORYLATION	454338	SKLKRSYsSPDITQA		molecular association, regulation		14-3-3 beta(INDUCES); 14-3-3 epsilon(INDUCES)		27565309; 8978	2	33	25		
ERK2	EC 2.7.11.24; KINASE; Kinase, protein; Protein kinase, CMGC; Protein kinase, Ser/Thr (non-receptor)	P28482	5594	MAPK1	22q11.21	human	Y187	PHOSPHORYLATION	447594	HTGFLTEyVATRWYR	Pkinase; YukC	activity, induced; protein degradation; molecular association, regulation; intracellular localization; protein conformation; phosphorylation; enzymatic activity, induced	cell motility, induced; cell differentiation, induced; cell motility, altered; cytoskeletal reorganization; transcription, inhibited; cell growth, altered	TACE(INDUCES); ERK2(INDUCES); GNB1(INDUCES); KSR(INDUCES)		30280005; 7397603; 902; 7119508; 4313628; 7674; 6121900; 3565; 3406; 7483320; 11975; 13354722; 6011114; 13872500; 5708; 3394329; 6842222; 4018; 6926; 25725907; 7550825; 4914001; 3342623; 3394311; 5930044; 1172804	974	85	3953	 increase of RhoA and Cdc42 activity, motility, migration, and invasion	
BRSK2	EC 2.7.11.1; EC 2.7.11.26; KINASE; Kinase, protein; Protein kinase, CAMK; Protein kinase, Ser/Thr (non-receptor)	Q69Z98	75770	Brsk2		mouse	T175	PHOSPHORYLATION	456031	VGDSLLEtSCGSPHY	Pkinase	enzymatic activity, induced	cytoskeletal reorganization	BRSK1(INDUCES); tau(INDUCES)		1193006	3	1	1	LKB1 phosphorylates Brsk1 and Brsk2.; Tau S262 is phosphoryated by LKB1 only in the presence of BRSK2. 	
Rb-like 2	Transcription, coactivator/corepressor	Q08999	5934	RBL2	16q12.2	human	S952	PHOSPHORYLATION	449732	DSRSHQNsPTELNKD	RB_B; BCS1_N	molecular association, regulation	cell cycle regulation	E2F4(DISRUPTS)		1200	2	8	1		
CYCS	Apoptosis; Mitochondrial; Oxidoreductase; Protein phosphatase, Ser/Thr (non-receptor)	P62894	510767	CYCS		cow	Y49	PHOSPHORYLATION	473243	GQAPGFSyTDANKNK	Cytochrom_C	activity, inhibited				14790302; 2725503	3	3	4	inhibits mitochondrial prespiration; Y48E mutation decreases CYCS redox potential	
PIK4CB iso2	Carbohydrate Metabolism - inositol phosphate; EC 2.7.1.67; Kinase, lipid; Motility/polarity/chemotaxis	Q9UBF8-2	5298	PI4KB	1q21	human	S496	PHOSPHORYLATION	457623	GDIRRRLsEQLAHTP		intracellular localization				7836	1	26	11	S496-phosphorylated PIK4CB localizes in the nucleus 	
CACNA1B	Channel, calcium; Membrane protein, integral; Membrane protein, multi-pass	Q02294	257648	Cacna1b		rat	S2016	PHOSPHORYLATION	25792205	TQPAPNAsPMKRSIS		protein conformation		RIMS1(INDUCES)		25712636	1	1	0	Calcium influx is increased due to open channel probability, facilitating neurotransmitter release by increasing number of docked vesicles at synaptic cleft.	
NKX3-1	DNA binding protein; Transcription factor	Q99801	4824	NKX3-1	8p21.2	human	S48	PHOSPHORYLATION	3078000	RQGGRTSsQRQRDPE	Trypan_PARP	molecular association, regulation			DNA(DISRUPTS)	8683	1	0	0		
MOR-1	GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR	P33535	25601	Oprm1		rat	S355	PHOSPHORYLATION	3063302	REFCIPTsSTIEQQN		receptor desensitization, altered; phosphorylation				8649	1	0	0		
MOR-1	GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR	P33535	25601	Oprm1		rat	S266	PHOSPHORYLATION	447782	LKSVRMLsGSKEKDR	7tm_1	receptor desensitization, altered				2603; 8656	3	0	1		
STMN1	Cytoskeletal protein	P54227	16765	Stmn1		mouse	S25	PHOSPHORYLATION	448555	QAFELILsPRSKESV	Stathmin		cytoskeletal reorganization			26349402	34	65	82		
KIF23	Microtubule binding protein; Motility/polarity/chemotaxis; Motor protein	E9Q5G3	71819	Kif23		mouse	S904	PHOSPHORYLATION	459840	TGSRKRRsSTLAPAQ		intracellular localization	cell cycle regulation; cytoskeletal reorganization			8646	4	8	261	regulates cytokinesis	
BACH1	DNA binding protein; Transcription factor	P97302	12013	Bach1		mouse	Y486	PHOSPHORYLATION	11498503	LEIGNYDyVSEPQQE		molecular association, regulation; intracellular localization	transcription, altered	exportin 1(INDUCES)		11419343	1	0	0		
SPRED2	Motility/polarity/chemotaxis; Vesicle protein	Q7Z698	200734	SPRED2	2p14	human	Y228	PHOSPHORYLATION	471403	EKIWMTGyEDYRHAP		protein degradation				9128	1	0	2	Pervanadate induced  Spred-2 degredation in ME4405 cells which is dependent on ubiquitination. 	
LAB	Adaptor/scaffold; Membrane protein, integral	Q9GZY6	7462	LAT2	7q11.23	human	Y136	PHOSPHORYLATION	450963	EDDDANSyENVLICK		molecular association, regulation	cell differentiation, altered	Grb2(INDUCES)		3080	3	6	169		
OSMR	Membrane protein, integral; Receptor, cytokine	Q99650	9180	OSMR	5p13.1	human	Y837	PHOSPHORYLATION	462479	TELTKPNyLYLLPTE		phosphorylation				2704330	2	1	15	important for  STAT5B activation	
WAVE2	Actin binding protein; Motility/polarity/chemotaxis	Q9Y6W5	10163	WASF2	1p36.11	human	S488	PHOSPHORYLATION	6377641	YSDSEDDsSEFDEDD		activity, inhibited	cytoskeletal reorganization			6337810	1	0	1		
PTPN22	EC 3.1.3.48; Motility/polarity/chemotaxis; PHOSPHATASE; Protein phosphatase, tyrosine (non-receptor)	Q9Y2R2	26191	PTPN22	1p13.2	human	S35	PHOSPHORYLATION	1725300	FLKLKRQsTKYKADK		enzymatic activity, inhibited; protein conformation				1713112	1	0	0	I-C11 compound inhibits phosphatase activity of PTPN22	
PDX1	DNA binding protein; Transcription factor	P52946	18609	Pdx1		mouse	S232	PHOSPHORYLATION	13421406	EQDCAVTsGEELLAV			transcription, inhibited			13359110	1	0	0		
PKCT	EC 2.7.11.13; KINASE; Kinase, protein; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor)	Q04759	5588	PRKCQ	10p15	human	S695	PHOSPHORYLATION	447906	QNMFRNFsFMNPGME	Pkinase_C	protein stabilization; molecular association, regulation; enzymatic activity, induced		PDK1(INDUCES)		6963; 4297; 1630	5	14	46	assayed in vitro	
C/EBP-beta	DNA binding protein; Motility/polarity/chemotaxis; Transcription factor	P28033	12608	Cebpb		mouse	T188	PHOSPHORYLATION	447878	SSSSPPGtPSPADAK		molecular association, regulation; protein conformation; phosphorylation	transcription, altered; cell growth, altered	MED1(INDUCES); C/EBP-beta(INDUCES)	DNA(INDUCES)	2425236; 4650403; 2653912; 6368; 1173006; 4641	28	5	0		
SPT5	Transcription, coactivator/corepressor	O00267	6829	SUPT5H	19q13	human	T791	PHOSPHORYLATION	458817	TPMYGSQtPLQDGSR	CTD		transcription, altered			7460	2	1	51	required for c-fos induction and activation in vivo	
PKAR2A	Protein kinase, regulatory subunit	P12368	29699	Prkar2a		rat	S97	PHOSPHORYLATION	458326	SKFTRRVsVCAETFN		molecular association, regulation; phosphorylation		PKACA(DISRUPTS)		4042503	7	35	162	regulates PKA-dependent substrate phosphorylation and calcium signaling in cardiac cells	
HBEGF	Cell surface; Membrane protein, integral	Q99075	1839	HBEGF	5q23	human	S207	PHOSPHORYLATION	2872001	VKLGMTNsH______			cell growth, altered			2865411	1	0	0		
14-3-3 gamma	Adaptor/scaffold	P61981	7532	YWHAG	7q11.23	human	S59	PHOSPHORYLATION	3892745	VVGARRSsWRVISSI	14-3-3	molecular association, regulation; intracellular localization		TNRC6A(INDUCES)		17431548	1	1	8	localizes to P-bodies	
SGK3	EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor)	Q9ERE3	170755	Sgk3		mouse	S486	PHOSPHORYLATION	448196	DDAFVGFsYAPPSED	Pkinase_C	enzymatic activity, induced	cell differentiation, altered; cell growth, altered			8802	4	0	0	S486 site is indispensible for kinase activation.	
MST1	Autophagy; EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, STE; Protein kinase, Ser/Thr (non-receptor)	Q9JI11	58231	Stk4		mouse	T387	PHOSPHORYLATION	450050	TMKRRDEtMQPAKPS		enzymatic activity, induced	cell adhesion, altered			2608	3	1	7		
ASL	Amino Acid Metabolism - alanine, aspartate and glutamate; Amino Acid Metabolism - arginine and proline; EC 4.3.2.1; Lyase	P04424	435	ASL	7q11.21	human	K288	ACETYLATION	27614500	SSLMPQKkNPDSLEL	Lyase_1	enzymatic activity, inhibited				12513600	0	1	0		
PUMA	Mitochondrial	Q9BXH1	27113	BBC3	19q13.3-q13.4	human	S10	PHOSPHORYLATION	18610000	RARQEGSsPEPVEGL		protein degradation	apoptosis, inhibited			21686204	2	3	0		
GLT1	Membrane protein, integral; Membrane protein, multi-pass; Transporter	P31596	29482	Slc1a2		rat	Y403	PHOSPHORYLATION	3064900	NMDGTALyEAVAAIF	SDF	activity, induced				8431	1	0	0	Y403H mutant sensitive to volatile anesthetics	
JNK1	EC 2.7.11.24; KINASE; Kinase, protein; Protein kinase, CMGC; Protein kinase, Ser/Thr (non-receptor)	Q91Y86	26419	Mapk8		mouse	Y185	PHOSPHORYLATION	447645	TSFMMTPyVVTRYYR	Pkinase	protein degradation; molecular association, regulation	transcription, altered	GSK3B(INDUCES); CTNNB1(INDUCES)		6804603	199	27	1233	degredation of beta-catenin.	
PTRH2	EC 3.1.1.29; Hydrolase; Mitochondrial	Q9Y3E5	51651	PTRH2	17q23.1	human	S87	PHOSPHORYLATION	4206800	GKVAAQCsHAAVSAY	PTH2		apoptosis, altered; cell adhesion, altered			4042515	1	0	0	associated with anoikis (cell death induced by detachment from the extracellular matrix)	
SSTR2	GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR	P30874	6752	SSTR2	17q24	human	S343	PHOSPHORYLATION	7652105	DDGERSDsKQDKSRL		receptor internalization, altered				18410845; 18415116	7	0	0		
MRCKA	EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor)	Q5VT25	8476	CDC42BPA	1q42.11	human	S234	PHOSPHORYLATION	12612500	MEDGTVQsSVAVGTP	Pkinase	enzymatic activity, induced	cytoskeletal reorganization			12482237	1	0	0		
JunB	Motility/polarity/chemotaxis; Transcription factor	P17275	3726	JUNB	19p13.2	human	T104	PHOSPHORYLATION	1814000	GVITTTPtPPGQYFY	Jun	activity, induced; molecular association, regulation	transcription, altered		DNA(INDUCES)	1813901	1	1	2	Phosphorylation of JunB increases cooperative binding with c-Maf to DNA.	
HSP90B	Chaperone	P08238	3326	HSP90AB1	6p12	human	S226	PHOSPHORYLATION	454114	KEREKEIsDDEAEEE	HSP90	activity, induced; molecular association, regulation	apoptosis, altered	APAF(DISRUPTS)		2831748	3	53	76		
tensin 3	Adaptor/scaffold; Motility/polarity/chemotaxis	Q68CZ2	64759	TNS3	7p12.3	human	Y1173	PHOSPHORYLATION	9824600	QDTSKFWyKADISRE	SH2	molecular association, regulation	cell motility, altered; cell growth, altered	P130Cas(INDUCES); Sam68(INDUCES); FAK(INDUCES)		9775901	1	0	0	contributes to tumorigenesis and metastasis	
Mos	EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor)	P12965	397924	mos		frog	S3	PHOSPHORYLATION	448658	_____MPsPIPVERF		protein stabilization; enzymatic activity, induced				8141; 8387	3	1	0	in Xenopus oocytes, not cell lines; necessary for oocyte maturation and the spindle assembly checkpoint	
SLC23A2	Membrane protein, integral; Membrane protein, multi-pass; Transporter	Q9EPR4	54338	Slc23a2		mouse	S640	PHOSPHORYLATION	483980	KSENSRSsDKDSQAT		intracellular localization	cell differentiation, altered			11985	1	0	0	Phosphorylation is required for SLC3A2 localization in plasma membrane, and ascorbic acid uptake.	
DDR1	EC 2.7.1.112; EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Protein kinase, TK; Protein kinase, tyrosine (receptor)	Q08345	780	DDR1	6p21.3	human	Y513	PHOSPHORYLATION	457956	LLLSNPAyRLLLATY		molecular association, regulation		Shc1(INDUCES)		7796	1	6	322		
NFAT4	DNA binding protein; Transcription factor	Q12968	4775	NFATC3	16q22.2	human	S207	PHOSPHORYLATION	11507602	AARFTLGsPLTSPGG		intracellular localization				10274612	1	0	1	cytoplasmic localization (inhibition of nuclear localization)	
GIT2	GTPase activating protein, ARF; Motility/polarity/chemotaxis	Q9Y621	374035	GIT2		chicken	Y592	PHOSPHORYLATION	450866	SSVPESDyDNTTASL		molecular association, regulation; intracellular localization	cell adhesion, altered	PXN(INDUCES)		6868	1	10	234		
BubR1	EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor)	O60566	701	BUB1B	15q15	human	T792	PHOSPHORYLATION	7652106	PRNSAELtVIKVSSQ		enzymatic activity, induced	cell cycle regulation			7654400	2	0	0	facilitates chromosome alignment during prometaphase	
PTRF	Transcription initiation complex	O54724	19285	Ptrf		mouse	T304	PHOSPHORYLATION	2566127	DKLRKSFtPDHVVYA	Peptidase_M3	phosphorylation				18119112	2	13	6	 regulates phosphorylation of HSL S557 (aka S563) and S651 (aka S660); regulates lipolysis in adipocytes	
LIP8	Cell cycle regulation	Q8N137	116840	CNTROB	17p13.1	human	S36	PHOSPHORYLATION	27565611	QVSSEVTsQLYASLR			cell motility, inhibited			27565307	1	0	0		
CACNA1D	Channel, calcium; Membrane protein, integral; Membrane protein, multi-pass	P27732	29716	Cacna1d		rat	S81	PHOSPHORYLATION	470135	PPPVGSLsQRKRQQY		activity, inhibited				9023	1	1	1		
Syk	EC 2.7.10.2; KINASE; Kinase, protein; Protein kinase, TK; Protein kinase, tyrosine (non-receptor)	P43405	6850	SYK	9q22	human	Y352	PHOSPHORYLATION	447660	TEVYESPyADPEEIR		molecular association, regulation; enzymatic activity, induced		CLTC(INDUCES); PLCG1(INDUCES); ITGAM(INDUCES)		6782010; 759; 7324306	21	14	249		
KCNMA1	Channel, potassium; Endoplasmic reticulum; Membrane protein, integral; Membrane protein, multi-pass	Q28265	403984	KCNMA1		dog	S1084	PHOSPHORYLATION	466425	QSSSKKSsSVHSIPS		activity, induced				3165	2	0	0	increases open probability of channel	
ER-alpha	DNA binding protein; Nuclear receptor	P03372	2099	ESR1	6q25.1	human	K268	ACETYLATION	461006	GGRMLKHkRQRDDGE		activity, induced; molecular association, regulation	transcription, altered		DNA(INDUCES)	11006907; 7811	2	1	0	K266/268Q or K266/268R mutations confer resistance to repression by BRCA1	
Myb	DNA binding protein; Transcription factor	P06876	17863	Myb		mouse	S528	PHOSPHORYLATION	453087	KIKQEVEsPTEKSGN	Cmyb_C	activity, induced; molecular association, regulation; activity, inhibited	transcription, inhibited	Pin1(INDUCES)		2151814; 4111	5	3	2	S528 phosphorylation negatively regulates transcription transactivating activity of Myb.	
RFC1	DNA replication	D3ZFT1	89809	Rfc1		rat	T110	PHOSPHORYLATION	468618	PVTYISEtDEDDDFL		intracellular localization	transcription, inhibited			8890	1	15	25		
MDC1	Cell cycle regulation	Q14676	9656	MDC1	6p21.3	human	T301	PHOSPHORYLATION	477987	PPGEDSDtDVDDDSR		molecular association, regulation	cell cycle regulation	NBS1(INDUCES)		4042508	1	12	22	MDC1-NBS1 interaction regulates intra-S-phase checkpoint activation	
POLR2A	EC 2.7.7.48; EC 2.7.7.6; Nucleotide Metabolism - purine; Nucleotide Metabolism - pyrimidine; Transcription initiation complex; Transferase	P24928	5430	POLR2A	17p13.1	human	S1619	PHOSPHORYLATION	447616	SPSYSPTsPSYSPTS	RNA_pol_Rpb1_R	molecular association, regulation; intracellular localization; enzymatic activity, induced	transcription, induced; transcription, altered; transcription, inhibited	CTDSP1(INDUCES); CABIN1(INDUCES); HIRA(INDUCES); UBN1(INDUCES)	DNA(INDUCES)	5121516; 11999208; 2672603; 2672602; 2610202; 15031314; 20655017; 17613008; 25220607; 3433204; 3433207	58	0	0	dephosphorylation of S1619 promotes termination	
JAK2	EC 2.7.10.2; KINASE; Kinase, protein; Protein kinase, TK; Protein kinase, tyrosine (non-receptor)	Q62689	24514	Jak2		rat	Y1007	PHOSPHORYLATION	448407	VLPQDKEyYKVKEPG	Pkinase_Tyr	enzymatic activity, induced				3645	46	3	15		
ARC	Apoptosis	Q62881	85383	Nol3		rat	T149	PHOSPHORYLATION	448618	SEAVQPRtPEEPELE	Trypan_PARP	molecular association, regulation; intracellular localization	apoptosis, inhibited	Casp2(INDUCES)		5358607; 1769; 7865	4	1	0	protects cells against oxidative stress; T149 phosphorylation promotes ARC localization to mitochondria, allowing ARC binding to Caspase-8.; T149D mutant inhibits apoptosis induced by isoproterenol or aldosterone	
PLK1	EC 2.7.11.21; KINASE; Kinase, protein; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor)	P53350	5347	PLK1	16p12.2	human	S597	PHOSPHORYLATION	23203000	LLSSRSAsNRLKAS_		molecular association, regulation	cell cycle regulation	14-3-3 zeta(INDUCES)		22999500; 27157300	2	0	0		
FGF10	Cell development/differentiation; Cytokine; Motility/polarity/chemotaxis; Secreted; Secreted, signal peptide	O15520	2255	FGF10	5p13-p12	human	T114	PHOSPHORYLATION	12063900	PYSILEItSVEIGVV	FGF	activity, induced; molecular association, regulation	cell growth, altered	FGFR2(NOT_REPORTED)		12028126	1	0	0		
CD1D	Apoptosis; Cell surface; Lipid binding protein; Membrane protein, integral	P15813	912	CD1D	1q22-q23	human	T322	PHOSPHORYLATION	14364502	FLLIVGFtSRFKRQT	TM	intracellular localization				14058607	2	0	1	regulates CD1D targeting to lysosomes	
CD44	Cell adhesion; Membrane protein, integral; Motility/polarity/chemotaxis; Receptor, misc.	P16070	960	CD44	11p13	human	S672	PHOSPHORYLATION	455524	AVCIAVNsRRRCGQK	Bravo_FIGEY	molecular association, regulation	cytoskeletal reorganization	ezrin(INDUCES)		5382	2	0	0		
CaR	GPCR, family 3; Membrane protein, integral; Membrane protein, multi-pass; Motility/polarity/chemotaxis; Receptor, GPCR	P41180	846	CASR	3q13	human	S895	PHOSPHORYLATION	11488701	TLRRSNVsRKRSSSL		activity, induced				11484401	1	0	0		
NFkB-p100	DNA binding protein; Transcription factor	Q00653	4791	NFKB2	10q24	human	S707	PHOSPHORYLATION	20804978	EPLCPLPsPPTSDSD		protein degradation; ubiquitination		FBXW7(INDUCES)		27105701	2	1	0		
DVL2	Adaptor/scaffold; Motility/polarity/chemotaxis	O14641	1856	DVL2	17p13.1	human	Y27	PHOSPHORYLATION	12170304	LDEEETPyLVKIPVP	DIX		transcription, induced			12021336	1	1	1	regulates Wnt3a/beta-catenin signaling 	
Pyk2	EC 2.7.10.2; KINASE; Kinase, protein; Nuclear receptor co-regulator; Protein kinase, TK; Protein kinase, tyrosine (non-receptor)	P70600	50646	Ptk2b		rat	Y402	PHOSPHORYLATION	447955	CSIESDIyAEIPDET		molecular association, regulation; protein conformation; phosphorylation	apoptosis, altered; cytoskeletal reorganization; cell adhesion, altered	FAK(INDUCES)		13270520; 4803; 4721	61	2	21		
InsR	EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Protein kinase, TK; Protein kinase, tyrosine (receptor)	P06213	3643	INSR	19p13.3-p13.2	human	Y1011	PHOSPHORYLATION	449048	DVFPCSVyVPDEWEV		enzymatic activity, inhibited				2086	5	0	2		
hnRNP P2	DNA binding protein; Nuclear receptor co-regulator; RNA binding protein; RNA splicing	P35637	2521	FUS	16p11.2	human	S257	PHOSPHORYLATION	450486	GRGGMGGsDRGGFNK		protein stabilization				3115	1	0	0	Phosphorylation-induced protein stabilization is observed only in those cells which overexpress BCR-ABL.
Ectopic expression of phosphomimetic S256D FUS mutant induces apoptosis and inhibits the differentiation of the cells escaping cell death. 	
SHARP	Nuclear receptor co-regulator; Spliceosome; Transcription factor	Q96T58	23013	SPEN	1p36	human	S3486	PHOSPHORYLATION	455623	QPAPKQDsSPHLTSQ			transcription, altered			5508	1	0	0		
ZIC2	C2H2-type zinc finger protein; DNA binding protein	Q62520	22772	Zic2		mouse	S200	PHOSPHORYLATION	1783002	EQYRQVAsPRTDPYS		activity, induced; molecular association, regulation	transcription, altered	DDX9(INDUCES)		1713121	1	1	0		
cortactin	Actin binding protein; Cytoskeletal protein; Motility/polarity/chemotaxis	Q14247	2017	CTTN	11q13	human	S418	PHOSPHORYLATION	447701	TEERLPSsPVYEDAA		molecular association, regulation; protein conformation	carcinogenesis, altered; endocytosis, altered; cell motility, altered; cytoskeletal reorganization; cell adhesion, altered	N-WASP(INDUCES)		14318400; 17431527	11	51	179		
MRLC2	Contractile protein	Q3THE2	67938	Myl12b		mouse	S3	PHOSPHORYLATION	448594	_____MSsKKAKTKT			cytoskeletal reorganization; cell adhesion, altered			970037	1	0	0	induced disassembly of stress fibers and decreased large focal adhesions	
PPP1R14B	Inhibitor protein; Protein phosphatase, regulatory subunit	Q96C90	26472	PPP1R14B	11q13	human	T57	PHOSPHORYLATION	1904503	VRRQGKVtVKYDRKE	PP1_inhibitor	activity, induced; activity, inhibited	cell motility, altered			12668810; 3049	4	1	0	inhibition of MLCP activity, activates contractile response in arterial smooth muscle; required for full inhibition of PP1CA in vitro. 	
ANXA2	Calcium-binding protein; Lipid binding protein; Motility/polarity/chemotaxis	P07355	302	ANXA2	15q22.2	human	T19	PHOSPHORYLATION	469172	SLEGDHStPPSAYGS		intracellular localization				15026105	1	10	24		
PTHR	GPCR, family 2; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR	P25961	56813	Pth1r		rat	S495	PHOSPHORYLATION	2853103	RSGSSSYsYGPMVSH		receptor internalization, altered				8759	2	0	0		
Kit	EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Protein kinase, TK; Protein kinase, tyrosine (receptor)	P05532	16590	Kit		mouse	Y732	PHOSPHORYLATION	454941	DMKPGVSyVVPTKTD	Pkinase_Tyr	activity, induced; phosphorylation	cell cycle regulation; cell growth, altered			4843008	1	3	29	promotes PLCg1 phosphorylation and Ca(2+) mobilization	
PDCD4	Apoptosis	Q53EL6	27250	PDCD4	10q24	human	S76	PHOSPHORYLATION	2588300	RDSGRGDsVSDSGSD		protein degradation; molecular association, regulation		BTRC(INDUCES)		2587201	1	16	72		
ERK7	EC 2.7.11.24; KINASE; Kinase, protein; Protein kinase, CMGC; Protein kinase, Ser/Thr (non-receptor)	Q8TD08	225689	MAPK15	8q24.3	human	T175	PHOSPHORYLATION	459216	GPEDQAVtEYVATRW	Pkinase	enzymatic activity, induced				7695; 7693	2	3	0	activated by c-Ret	
FOXP3	C2H2-type zinc finger protein; Cell cycle regulation; DNA binding protein; Transcription factor	Q99JB6	20371	Foxp3		mouse	S19	PHOSPHORYLATION	12201088	PSLALGPsPGVLPSW		protein degradation	cell growth, induced; transcription, altered			28722401	1	1	1	Alanine mutants inhibited (lL2) or induced (CD25) transcription of FOXP3 responsive genes, suppressed T cell proliferation, and showed an anti-inflamatory effect of  a murine colitis model.	
polycystin 2	Channel, cation; Membrane protein, integral; Membrane protein, multi-pass	Q13563	5311	PKD2	4q22.1	human	S76	PHOSPHORYLATION	460685	AGAAASPsPPLSSCS		intracellular localization				7740	1	2	0		
ARHGEF7	Guanine nucleotide exchange factor, Rac/Rho; Motility/polarity/chemotaxis	Q9ES28	54126	Arhgef7		mouse	S682	PHOSPHORYLATION	455681	EEFAVRKsTAALEED		intracellular localization				5687	3	12	2		
Ron	EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Protein kinase, TK; Protein kinase, tyrosine (receptor)	Q62190	19882	Mst1r		mouse	Y1175	PHOSPHORYLATION	456482	QVACGMEyLAEQKFV	Pkinase_Tyr	enzymatic activity, induced		Src(NOT_REPORTED)		6720	1	0	0	this site is responsible for constitutive activation of the MAP kinase pathway	
DAPK3	EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, CAMK; Protein kinase, Ser/Thr (non-receptor)	O43293	1613	DAPK3	19p13.3	human	T265	PHOSPHORYLATION	454892	KDPKRRMtIAQSLEH	Pkinase	enzymatic activity, induced	cytoskeletal reorganization			4344; 9197	3	1	0		
Chk1	EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, CAMK; Protein kinase, Ser/Thr (non-receptor)	O35280	12649	Chek1		mouse	S345	PHOSPHORYLATION	447834	LVQGISFsQPTCPEH		intracellular localization	cell cycle regulation; apoptosis, altered			1173031	99	0	11		
SCN2A	Channel, sodium; Membrane protein, integral; Membrane protein, multi-pass	P04775	24766	Scn2a		rat	S1506	PHOSPHORYLATION	2999207	NAMKKLGsKKPQKPI		activity, inhibited				8665	1	0	0		
DNMT1	Amino Acid Metabolism - cysteine and methionine; Cell development/differentiation; EC 2.1.1.37; Methyltransferase; Methyltransferase, DNA; Transcription regulation	P13864	13433	Dnmt1		mouse	S515	PHOSPHORYLATION	458936	MQEKIYIsKIVVEFL	DNMT1-RFD	protein conformation; enzymatic activity, induced				2195718	2	2	0	important for an interaction between the N-terminal and the catalytic domain of DNMT1	
CACNG2	Channel, calcium; Membrane protein, integral; Membrane protein, multi-pass	O88602	12300	Cacng2		mouse	S240	PHOSPHORYLATION	455316	YQRRSRSsSRSTEPS	Tetraspannin	activity, induced; intracellular localization				22913905; 4485	1	0	0	AMPAR immobilization in synaptic membrane; enhances AMPA receptor responses and is required for long-term potentiation	
ID1	DNA binding protein; Transcription, coactivator/corepressor	P20067	15901	Id1		mouse	S5	PHOSPHORYLATION	479430	___MKVAsGSAAAAA		intracellular localization				11470	1	0	0	forskolin-induced nuclear localization	
pleckstrin	Lipid binding protein	P08567	5341	PLEK	2p13.3	human	S113	PHOSPHORYLATION	451305	GQKFARKsTRRSIRL		activity, induced				11484402	2	0	150		
POLH	DNA repair; EC 2.7.7.7; Transferase	Q9Y253	5429	POLH	6p21.1	human	S601	PHOSPHORYLATION	18330800	EMDLAHNsQSMHASS	PRP21_like_P		cell cycle regulation			18119103	1	0	1	influences cell survival	
CAMKK1	EC 2.7.11.17; KINASE; Kinase, protein; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor)	P97756	60341	Camkk1		rat	T108	PHOSPHORYLATION	452083	PRAWRRPtIESHHVA		enzymatic activity, inhibited				12482208	6	0	0		
DBF4	Cell cycle regulation; Protein kinase, regulatory subunit	Q9UBU7	10926	DBF4	7q21.3	human	S539	PHOSPHORYLATION	482262	GLITINSsQEHLTVQ			cell cycle regulation			22965803	1	1	0	DBF4 phosphorylaion is important for supressing DNA replication.	
GluR4	Channel, ligand-gated; Membrane protein, integral; Membrane protein, multi-pass	P48058	2893	GRIA4	11q22	human	S862	PHOSPHORYLATION	448810	IRNKARLsITGSVGE		molecular association, regulation		ACTN1(DISRUPTS)		8531	5	5	1	Phosphorylation alters GluR4 binding to alpha-actinin in vitro and in vivo, but has no affect on IQGAP1 binding.	
axin 1	Adaptor/scaffold	O35625	12005	Axin1		mouse	T480	PHOSPHORYLATION	451091	HVQRVMRtPGCQSPG	Axin_b-cat_bind	activity, induced; molecular association, regulation; intracellular localization	cell differentiation, induced; cytoskeletal reorganization	GSK3B(INDUCES)		3178; 28722176; 22726508	4	2	0	axon formation; Phosphorylation plays a role in the activation of axin to modulate Lef/Tcf signaling.  Phosphorylation by GSK3beta also leads to increased direct binding of beta-catenin in vitro.; nuclear localization	
PKCA	EC 2.7.11.13; KINASE; Kinase, protein; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor)	P04409	282001	PRKCA		cow	T638	PHOSPHORYLATION	448685	TRGQPVLtPPDQLVI	Pkinase_C	phosphorylation; enzymatic activity, induced				1239	17	6	1	prolongs activation kinetics (not activity itself) and protection from phosphatases	
CACNA1C	Channel, calcium; Membrane protein, integral; Membrane protein, multi-pass	Q01815	12288	Cacna1c		mouse	S1545	PHOSPHORYLATION	467228	VACKRLVsMNMPLNS		activity, induced				14551419	2	0	0	mediates Ca2+ current facilitation 	
BARD1	EC 6.3.2.-; EC 6.3.2.19; Ligase; Tumor suppressor; UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase	Q99728	580	BARD1	2q34-q35	human	S186	PHOSPHORYLATION	455772	SYEFVSPsPPADVSE			cell cycle regulation			5849	1	3	0	resistance to genotoxic stress (mitomycin C)	
PEA-15	Apoptosis; Motility/polarity/chemotaxis	Q62048	18611	Pea15		mouse	S104	PHOSPHORYLATION	455750	TKLTRIPsAKKYKDI		molecular association, regulation	cell cycle regulation	ERK1(DISRUPTS); ERK2(DISRUPTS)		5780	7	9	308		
Btk	EC 2.7.10.2; KINASE; Kinase, protein; Protein kinase, TK; Protein kinase, tyrosine (non-receptor)	Q06187	695	BTK	Xq21.33-q22	human	Y551	PHOSPHORYLATION	447486	RYVLDDEyTSSVGSK	Pkinase_Tyr	activity, induced; molecular association, regulation; intracellular localization; enzymatic activity, induced		BLNK(INDUCES)		4533; 2653911; 1747; 6412; 1760	22	9	135		
SQSTM1	Autophagy; Nuclear receptor co-regulator; Ubiquitin conjugating system	Q64337	18412	Sqstm1		mouse	T269	PHOSPHORYLATION	457004	GGKRSRLtPTTPESS			cell cycle regulation; carcinogenesis, altered			17431509	2	33	104	in Ras-transformed embryonic fibroblasts	
SLC12A3	Membrane protein, integral; Membrane protein, multi-pass; Transporter	P55017	6559	SLC12A3	16q13	human	T55	PHOSPHORYLATION	469616	SSTFCMRtFGYNTID	AA_permease_N	molecular association, regulation		ADD3(DISRUPTS)		17714504	14	3	0	ADD3 stimulates SLC12A3 activity	
LDH-A	Amino Acid Metabolism - cysteine and methionine; Apoptosis; Carbohydrate Metabolism - glycolysis and gluconeogenesis; Carbohydrate Metabolism - propanoate; Carbohydrate Metabolism - pyruvate; EC 1.1.1.27; Oxidoreductase	P00338	3939	LDHA	11p15.4	human	Y10	PHOSPHORYLATION	454712	TLKDQLIyNLLKEEQ		molecular association, regulation; enzymatic activity, induced	carcinogenesis, induced; cell growth, induced	LDH-A(INDUCES)		21683725	1	11	323		
ICAM3	Cell adhesion; Immunoglobulin superfamily; Membrane protein, integral	P32942	3385	ICAM3	19p13.3-p13.2	human	S518	PHOSPHORYLATION	451020	REHQRSGsYHVREES		activity, induced; intracellular localization				3443; 3272	2	0	2		
EphA3	EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Protein kinase, TK; Protein kinase, tyrosine (receptor)	P29319	13837	Epha3		mouse	Y779	PHOSPHORYLATION	448910	EDDPEAAyTTRGGKI	Pkinase_Tyr		cell cycle regulation; carcinogenesis, altered; cell motility, altered			15278817; 2790302	3	21	724		
KCC1	Membrane protein, integral; Membrane protein, multi-pass; Transporter	Q9UP95	6560	SLC12A4	16q22.1	human	Y1056	PHOSPHORYLATION	3087800	NSEGDENyMEFLEVL		activity, inhibited				8592	1	0	0		
TXK	EC 2.7.1.112; EC 2.7.10.2; KINASE; Kinase, protein; Protein kinase, TK; Protein kinase, tyrosine (non-receptor)	P42681	7294	TXK	4p12	human	Y91	PHOSPHORYLATION	2861416	KIQVKALyDFLPREP	SH3_1		transcription, altered			2852663	2	2	0		
H2B	DNA binding protein	P33778	3018	HIST1H2BB	6p21.3	human	S33	PHOSPHORYLATION	447801	DGKKRKRsRKESYSI	Histone		cell growth, induced; translation, induced			21655804	7	0	0	transformation 	
PPP1R3B	Protein phosphatase, regulatory subunit	Q86XI6	79660	PPP1R3B	8p23.1	human	Y285	PHOSPHORYLATION	1065300	YEKLGPYy_______		molecular association, regulation		PYGM(INDUCES)		970013	0	0	0		
restin	Cytoskeletal protein	Q9JK25	65201	Rsn		rat	S311	PHOSPHORYLATION	4769833	ASLKRSPsASSLSSM		molecular association, regulation; protein conformation		TUBA1C(DISRUPTS)		15031338	2	5	1		
mTOR	Autophagy; EC 2.7.11.1; KINASE; Kinase, protein; Motility/polarity/chemotaxis; Protein kinase, ATYPICAL; Protein kinase, Ser/Thr (non-receptor)	P42346	56718	Mtor		rat	S2448	PHOSPHORYLATION	447578	RSRTRTDsYSAGQSV			translation, altered			5968	90	6	84		
NDFIP2	Adaptor/scaffold; Membrane protein, integral; Membrane protein, multi-pass	Q9NV92	54602	NDFIP2	13q31.1	human	Y177	PHOSPHORYLATION	15229527	FYPVPPPySVATSLP	DUF2370	phosphorylation				25779412	1	0	1	Y167, Y177 and Y186 phosphorylation are dependent on Y171 phosphorylation.	
caveolin-1	Adaptor/scaffold; Motility/polarity/chemotaxis; Nuclear receptor co-regulator	P49817	12389	Cav1		mouse	Y14	PHOSPHORYLATION	448422	VDSEGHLyTVPIREQ		intracellular localization	cell adhesion, altered			6766; 2483408	35	28	794	regulates lipid order (lipid rafts) around focal adhesions	
KCNMB4	Channel, potassium; Membrane protein, integral; Membrane protein, multi-pass	Q86W47	27345	KCNMB4	12q	human	S17	PHOSPHORYLATION	451269	YTEAEDKsIRLGLFL	CaKB	activity, inhibited				3490	1	0	0	regulates slowpoke K(+) channel kinetics	
LIMK1	EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, Ser/Thr (non-receptor); Protein kinase, TKL	P53667	3984	LIMK1	7q11.23	human	T508	PHOSPHORYLATION	447808	PDRKKRYtVVGNPYW	Pkinase_Tyr	activity, induced; molecular association, regulation; enzymatic activity, induced		NISCH(INDUCES)		4215302; 1154; 6329; 4404	16	0	0		
Cbl	Adaptor/scaffold; EC 6.3.2.-; EC 6.3.2.19; Ligase; Motility/polarity/chemotaxis; UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase	P22681	867	CBL	11q23.3	human	Y731	PHOSPHORYLATION	448530	QQIDSCTyEAMYNIQ		activity, induced; protein degradation; molecular association, regulation; phosphorylation	cell motility, altered; cell growth, altered	Src(INDUCES); PIK3R1(INDUCES)		5724; 6767; 4181; 623; 5178; 2039601	12	0	34		
WAVE2	Actin binding protein; Motility/polarity/chemotaxis	Q9Y6W5	10163	WASF2	1p36.11	human	Y150	PHOSPHORYLATION	455197	GKEALKFyTDPSYFF		molecular association, regulation; intracellular localization	cytoskeletal reorganization	Abi-1(INDUCES)		4442	3	0	0		
MafA	DNA binding protein; Transcription factor	O57342		MAFA		quail	S272	PHOSPHORYLATION	456030	RGFPRETsPPAAPKT			cell differentiation, altered; transcription, altered			6333	3	3	0		
IRS2	Adaptor/scaffold; Motility/polarity/chemotaxis	NP_001162104	29376	Irs2		rat	S574	PHOSPHORYLATION	483923	GLRKRTYsLTTPARQ		molecular association, regulation; phosphorylation		14-3-3 beta(INDUCES)		25712647	1	17	9	negatively regulates IGF-1/insulin signaling 	
ADD2	Cytoskeletal protein; Motility/polarity/chemotaxis	Q05764	24171	Add2		rat	S692	PHOSPHORYLATION	454590	SVTSGPLsPEGSPSK			cytoskeletal reorganization			23940900	1	9	0		
Kv2.1	Channel, cation; Channel, ligand-gated; Channel, potassium; Membrane protein, integral; Membrane protein, multi-pass	P15387	25736	Kcnb1		rat	S541	PHOSPHORYLATION	473556	SKMAKTQsQPILNTK	Kv2channel	activity, inhibited				9216	3	6	0		
AML2	DNA binding protein; Transcription factor	Q13761	864	RUNX3	1p36	human	T153	PHOSPHORYLATION	6097700	RGKSFTLtITVFTNP	Runt	protein stabilization; intracellular localization	cell cycle regulation; transcription, altered			6095014	1	1	0		
ARHGEF7	Guanine nucleotide exchange factor, Rac/Rho; Motility/polarity/chemotaxis	Q9ES28	54126	Arhgef7		mouse	T683	PHOSPHORYLATION	455216	EFAVRKStAALEEDA		intracellular localization				5687	6	4	1		
Src	EC 2.7.10.2; KINASE; Kinase, protein; Protein kinase, TK; Protein kinase, tyrosine (non-receptor)	P12931	6714	SRC	20q12-q13	human	Y419	PHOSPHORYLATION	448234	RLIEDNEyTARQGAK	Pkinase_Tyr	molecular association, regulation; enzymatic activity, induced	cell cycle regulation; carcinogenesis, altered; cell motility, induced; cell motility, altered; cell adhesion, altered; cytoskeletal reorganization; signaling pathway regulation; cell growth, altered	Cbl-c(INDUCES); SHPS1(INDUCES)		14821622; 14148616; 30280005; 4678; 13359103; 3989; 6447; 5690; 6566; 4675; 4313605; 27902352; 5309419; 6018	267	61	3059	 increase of RhoA and Cdc42 activity, motility, migration, and invasion; regulates FAK activity ; invasion; Srx regulates PTB1B and Src kinase activity 	
Smad3	DNA binding protein; Nuclear receptor co-regulator; Transcription factor	P84022	4088	SMAD3	15q22.33	human	T8	PHOSPHORYLATION	452179	MSSILPFtPPIVKRL			cell cycle regulation; transcription, inhibited; transcription, altered			15658700; 4092	5	1	0		
HIF1A	Autophagy; DNA binding protein; Transcription factor	Q16665	3091	HIF1A	14q23.2	human	S641	PHOSPHORYLATION	470105	DIKILIAsPSPTHIH		activity, induced; intracellular localization	transcription, induced; transcription, altered	exportin 1(DISRUPTS)		8935; 6011123	2	0	0		
CAMK2G	EC 2.7.11.17; KINASE; Kinase, protein; Protein kinase, CAMK; Protein kinase, Ser/Thr (non-receptor)	Q13555	818	CAMK2G	10q22	human	S26	PHOSPHORYLATION	455247	ELGKGAFsVVRRCVK	Pkinase	enzymatic activity, inhibited; phosphorylation				27519627	1	3	0	 phosphorylation works as an internal break, switching off the constitutively active oligomeric CaMKII.; decreases T287 autophosphorylation	
NF1 iso2	GTPase activating protein, Ras; Motility/polarity/chemotaxis; Tumor suppressor	P21359-2	4763	NF1	17q11.2	human	T2554	PHOSPHORYLATION	456019	KMRRVAEtDYEMETQ		molecular association, regulation; activity, inhibited		14-3-3 beta(INDUCES)		6580	1	0	0		
Myc	DNA binding protein; Transcription factor	P01108	17869	Myc		mouse	T58	PHOSPHORYLATION	448496	KKFELLPtPPLSPSR	Myc_N	protein degradation; molecular association, regulation	cell differentiation, altered	Pin1(INDUCES)		4677; 25227611; 9401440	42	16	22		
PKD1	Autophagy; EC 2.7.11.13; KINASE; Kinase, protein; Motility/polarity/chemotaxis; Protein kinase, CAMK; Protein kinase, Ser/Thr (non-receptor)	Q62101	18760	Prkd1		mouse	Y469	PHOSPHORYLATION	448648	NDTGSRYyKEIPLSE	PH	enzymatic activity, induced				3602	7	0	0		
SOX9	DNA binding protein; Transcription factor	Q04887	20682	Sox9		mouse	S211	PHOSPHORYLATION	450957	FKALQADsPHSSSGM		activity, induced	transcription, altered			9201006	1	0	0	promotes expression of osteochondrogenic markers 	
myocardin	Cell development/differentiation; Transcription factor	Q8VIM5	214384	Myocd		mouse	S866	PHOSPHORYLATION	10791201	SPMHAQLsPPSVDSS		molecular association, regulation	transcription, inhibited	CBP(DISRUPTS)		10353931	1	0	0		
PAM	EC 1.14.17.3; EC 4.3.2.5; Lyase; Membrane protein, integral; Oxidoreductase; Vesicle protein	P14925	25508	Pam		rat	S949	PHOSPHORYLATION	453092	DRVSTEGsDQEKDED		intracellular localization; enzymatic activity, induced				14081217; 6322	3	6	1		
EphA8	EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Protein kinase, TK; Protein kinase, tyrosine (receptor)	O09127	13842	Epha8		mouse	Y615	PHOSPHORYLATION	448558	FSAEPHTyEEPGRAG		molecular association, regulation	cell adhesion, altered	Fyn(INDUCES)		1651	1	0	0		
NEUROD1	DNA binding protein; Transcription factor	Q64289	29458	Neurod1		rat	S336	PHOSPHORYLATION	451110	IPIDNIMsFDSHSHH			cell growth, altered			3307	2	0	0		
Lasp-1	Actin binding protein; Motility/polarity/chemotaxis	Q14847	3927	LASP1	17q11-q21.3	human	Y171	PHOSPHORYLATION	451675	IPTSAPVyQQPQQQP		intracellular localization	apoptosis, induced; cell motility, altered			10430800; 3780	2	6	419	important for cell spreading	
NMDAR2B	Channel, calcium; Channel, ligand-gated; Membrane protein, integral; Membrane protein, multi-pass	Q01097	14812	Grin2b		mouse	S1303	PHOSPHORYLATION	450171	NKLRRQHsYDTFVDL	NMDAR2_C	activity, induced				12558704	20	9	12	increases the channel conductance	
Huntingtin	Cytoskeletal protein	P51111	29424	Htt		rat	S1170	PHOSPHORYLATION	465620	EQTSTPMsPKKGGEA			apoptosis, inhibited			12086	2	9	2	regulates neuronal death through a p53-dependent pathway	
SPAG5	Cell cycle regulation	Q7TME2	54141	Spag5		mouse	T24	PHOSPHORYLATION	11270701	KGKPAMStPLRELKL			cell cycle regulation			11270013	1	1	0	T24/66/447A mutant impairs meiosis progression	
CK1E	EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, CK1; Protein kinase, Ser/Thr (non-receptor)	P49674	1454	CSNK1E	22q13.1	human	T334	PHOSPHORYLATION	453418	ALPPGPPtGATANRL		enzymatic activity, inhibited				8419; 2331	2	0	0	some subset of these 8 sites	
HABP4	Transcription regulation	Q5JVS0	22927	HABP4	9q22.3-q31	human	T354	PHOSPHORYLATION	11380902	RKPANDItSQLEINF		molecular association, regulation; intracellular localization		RACK1(DISRUPTS)		10296911	1	0	0	HABP4 associates with RACK1 in the nucleus but exits after activation with PMA	
Tiam2	Apoptosis; Guanine nucleotide exchange factor, Rac/Rho	Q6ZPF3	24001	Tiam2		mouse	T1662	PHOSPHORYLATION	478913	STKRGRGtLLKAQTR		molecular association, regulation	cell growth, altered	MAP1B(DISRUPTS); MAP1A(DISRUPTS); 14-3-3 epsilon(DISRUPTS)		11482	1	0	0	 inhibits neurite growth; suppresses Rac1 activation in vivo	
ITGB3	Cell adhesion; Membrane protein, integral; Motility/polarity/chemotaxis	O54890	16416	Itgb3		mouse	Y772	PHOSPHORYLATION	448012	DTANNPLyKEATSTF	Integrin_b_cyt	molecular association, regulation; protein processing; activity, inhibited		Shc1(INDUCES)		2512002; 8535	17	7	100	inhibits m-calpain cleavage	
tau	Cytoskeletal protein	P10637	17762	Mapt		mouse	S554	PHOSPHORYLATION	447930	NVRSKIGsTENLKHQ	Tubulin-binding	protein degradation				25785413	68	8	2	LKB1-MARK signaling causes proteasome-mediated degradation of Tau. 	
Smad3	DNA binding protein; Nuclear receptor co-regulator; Transcription factor	P84022	4088	SMAD3	15q22.33	human	S422	PHOSPHORYLATION	449603	GSPSIRCsSVS____			transcription, altered			1275	1	0	0	The triple mutants(S422/423/425A and S422/423/425D) were used in these experiments 	
PIP5K1B	Carbohydrate Metabolism - inositol phosphate; EC 2.7.1.68; Kinase, lipid	P70181	18719	Pip5k1b		mouse	S214	PHOSPHORYLATION	455789	STYKRRAsRKEREKP	PIP5K	activity, inhibited				5941	1	0	0		
PFKFB2	Carbohydrate Metabolism - fructose and mannose; EC 2.7.1.105; EC 3.1.3.46; Kinase, other; Motility/polarity/chemotaxis; Phosphatase (non-protein)	P26285	287019	PFKFB2		cow	T476	PHOSPHORYLATION	465673	TPLSSSNtIRRPRNY		enzymatic activity, induced				1066009	2	1	7		
CYBA	EC 1.-.-.-; Membrane protein, integral; Oxidoreductase	P13498	1535	CYBA	16q24	human	T147	PHOSPHORYLATION	7103047	ERPQIGGtIKQPPSN	Cytochrom_B558a	molecular association, regulation; enzymatic activity, induced		p47phox(INDUCES)		11419370	1	6	4		
InsR	EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Protein kinase, TK; Protein kinase, tyrosine (receptor)	P06213	3643	INSR	19p13.3-p13.2	human	Y1185	PHOSPHORYLATION	447680	FGMTRDIyETDYYRK	Pkinase_Tyr	molecular association, regulation; receptor internalization, altered; enzymatic activity, induced		IRS2(INDUCES); APS(INDUCES); PTP1B(INDUCES)		4642412; 2852622; 9082; 3694; 2178; 8589	33	19	453		
HDAC5	EC 3.5.1.98; Hydrolase	Q9UQL6	10014	HDAC5	17q21	human	S279	PHOSPHORYLATION	4788487	KVAERRSsPLLRRKD		molecular association, regulation; intracellular localization; protein conformation; enzymatic activity, induced	transcription, inhibited	SMRT(INDUCES); N-CoR1(DISRUPTS); GPS2(INDUCES); HDAC3(INDUCES); TBL1X(INDUCES); TBL1XR1(INDUCES); 14-3-3 beta(DISRUPTS)		17431525; 15235228	5	8	1		
ADD3	Cytoskeletal protein; Motility/polarity/chemotaxis	Q62847	25230	Add3		rat	S692	PHOSPHORYLATION	452158	KKKFRTPsFLKKNKK		intracellular localization				4014	2	27	159		
NFAT3	DNA binding protein; Transcription factor	Q8K120	73181	Nfatc4		mouse	S168	PHOSPHORYLATION	448859	QGGGAFFsPSPGSSS		activity, inhibited	transcription, altered			4215307; 4049508	5	0	1		
SSB	Transcription initiation complex	P32067	20823	Ssb		mouse	T301	PHOSPHORYLATION	452110	LLRNKKVtWKVLEGH	RRM_3	activity, induced; intracellular localization				6420300	1	1	0	nuclear export	
NFAT1	DNA binding protein; Transcription factor	Q60591	18019	Nfatc2		mouse	S219	PHOSPHORYLATION	447846	AHYSPRTsPIMSPRT			transcription, inhibited			1188	2	7	3		
ITGAM	Cell adhesion; Membrane protein, integral; Motility/polarity/chemotaxis	P11215	3684	ITGAM	16p11.2	human	S1142	PHOSPHORYLATION	467233	RQYKDMMsEGGPPGA	Integrin_alpha	activity, induced; molecular association, regulation	cell motility, altered; cell adhesion, altered	ICAM1(INDUCES); ICAM2(INDUCES)		8146	1	0	0	important for emigration of leukocytes from bloodstream to tissues in vivo	
TGM2	EC 2.3.2.13; KINASE; Transferase	P21980	7052	TGM2	20q12	human	S216	PHOSPHORYLATION	467223	RDCSRRSsPVYVGRV		molecular association, regulation		14-3-3 epsilon(INDUCES)		8148	3	2	2		
CENPA	DNA binding protein	P49450	1058	CENPA	2p23.3	human	S7	PHOSPHORYLATION	448601	_MGPRRRsRKPEAPR		molecular association, regulation; intracellular localization	cell cycle regulation; chromatin organization, altered	AurA(INDUCES)		1114; 2957	12	0	0	Aurora B, INCEP  and PP1gamma are mislocalized during anaphase in mitosis in mutants. ; S7A mutation causes defective kinetochore function and mislocalization of Aurora B. 	
SREBP-1 iso3	DNA binding protein; Membrane protein, integral; Membrane protein, multi-pass; Transcription factor	P36956-3	6720	SREBF1	17p11.2	human	S314	PHOSPHORYLATION	458357	IEKRYRSsINDKIIE	HLH	molecular association, regulation	transcription, inhibited	SREBP-1 iso3(DISRUPTS)		7368	2	0	0	inhibits lipogenesis	
NCAM1	Cell adhesion; Membrane protein, integral; Motility/polarity/chemotaxis	P13596	24586	Ncam1		rat	Y744	PHOSPHORYLATION	454070	VVMDITCyFLNKCGL	Shisa		cell growth, altered			15022713	2	0	0		
CTNNB1	Actin binding protein; Cell adhesion; Motility/polarity/chemotaxis; Nuclear receptor co-regulator; Transcription factor	Q9WU82	84353	Ctnnb1		rat	T41	PHOSPHORYLATION	447583	GIHSGATtTAPSLSG		protein degradation				3803	44	3	0		
NEK6	EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor)	Q9HC98	10783	NEK6	9q33.3-q34.11	human	Y108	PHOSPHORYLATION	12475501	NHPNIIKyLDSFIED	Pkinase	enzymatic activity, inhibited				12343102	1	0	0		
CNR1	GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR	P47746	12801	Cnr1		mouse	S463	PHOSPHORYLATION	22342305	KIAKVTMsVSTDTSA		receptor desensitization, induced				21686207	1	0	0		
P70S6KB	EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor); Translation	Q9UBS0	6199	RPS6KB2	11q13.2	human	S417	PHOSPHORYLATION	455990	SPRRLNSsPRAPVSP		enzymatic activity, induced				6518	2	3	11		
OSBP	Lipid binding protein	P22059	5007	OSBP	11q12-q13	human	S240	PHOSPHORYLATION	484804	TALQRSLsELESLKL		activity, inhibited				18410803	2	24	14		
IRF7	DNA binding protein; Transcription factor	P70434	54123	Irf7		mouse	S429	PHOSPHORYLATION	1276104	EGVSSLDsSSLGLCL			transcription, induced		DNA(INDUCES)	12173	1	0	0		
Cx43	Channel, misc.; Membrane protein, integral; Membrane protein, multi-pass; Motility/polarity/chemotaxis	P08050	24392	Gja1		rat	Y247	PHOSPHORYLATION	447814	VKGRSDPyHATTGPL		activity, inhibited	carcinogenesis, altered; cell growth, altered			8178; 8413; 15235238	7	8	249	 allows anchorage-independent growth; inhibits exchange of ions and metabolites between cells via gap junctions ; inhibits Src activity; disrupts gap junction communication	
p27Kip1	Cell cycle regulation; Inhibitor protein; Protein kinase, regulatory subunit	P46414	12576	Cdkn1b		mouse	T187	PHOSPHORYLATION	447875	NAGTVEQtPKKPGLR		ubiquitination	cell cycle regulation; cell differentiation, altered; apoptosis, altered; cell growth, altered			11999217; 6255; 17613006	38	0	0	neurite outgrowth	
Syk	EC 2.7.10.2; KINASE; Kinase, protein; Protein kinase, TK; Protein kinase, tyrosine (non-receptor)	P48025	20963	Syk		mouse	Y346	PHOSPHORYLATION	447660	TEVYESPyADPEEIR		molecular association, regulation; phosphorylation; enzymatic activity, induced	endocytosis, altered; cell motility, altered; cell adhesion, altered; signaling pathway regulation	Fgr(INDUCES)		7991125; 1973; 4300; 4357	21	14	249		
Hck	EC 2.7.10.2; KINASE; Kinase, protein; Protein kinase, TK; Protein kinase, tyrosine (non-receptor)	P08631	3055	HCK	20q11-q12	human	Y522	PHOSPHORYLATION	448322	YTATESQyQQQP___		activity, inhibited	cell growth, altered			1652	3	6	332		
AQP2	Channel, misc.; Membrane protein, integral; Membrane protein, multi-pass	P34080	25386	Aqp2		rat	S256	PHOSPHORYLATION	449854	REVRRRQsVELHSPQ		molecular association, regulation; intracellular localization	endocytosis, inhibited	GDI2(DISRUPTS); HSP70(DISRUPTS); RAN(DISRUPTS); HSC70(DISRUPTS); ANXA2(DISRUPTS); GRP78(INDUCES); PPP1CA(DISRUPTS)		27981100; 8339; 2704332; 3401; 6829231; 2396; 5292; 25608318	48	7	0		
PDK1	EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor)	O15530	5170	PDPK1	16p13.3	human	S394	PHOSPHORYLATION	12729600	QVSSSSSsHSLSASD			apoptosis, altered; cell growth, altered			11999212	2	0	0		
TOP2A	EC 5.99.1.3; Isomerase	P11388	7153	TOP2A	17q21-q22	human	S1365	PHOSPHORYLATION	18016961	TKTSPKLsNKELKPQ		protein degradation; molecular association, regulation; ubiquitination; phosphorylation		FBXW7(INDUCES)		18119105	1	1	0		
TDP43	RNA binding protein	Q921F2	230908	Tardbp		mouse	S410	PHOSPHORYLATION	3084601	SSMDSKSsGWGM___		ubiquitination				28722194	18	0	0	Phosphorylated, ubiqitinated protein forms insoluble aggregates.	
NUMBL	Cell development/differentiation	BAE45129	292732	Numbl		rat	S304	PHOSPHORYLATION	456489	EQLVRQGsFRGFPAL	NumbF	molecular association, regulation		14-3-3 eta(INDUCES)		6681	1	1	7		
Bcl-10	Apoptosis; Transcription, coactivator/corepressor	Q9Z0H7	12042	Bcl10		mouse	S134	PHOSPHORYLATION	467254	AGATNNLsRCNSDES		activity, induced; protein degradation				11753	3	4	3		
NR0B2	Nuclear receptor co-regulator; Transcription, coactivator/corepressor	Q62227	23957	Nr0b2		mouse	S26	PHOSPHORYLATION	7596703	TILYALLsPSPRTRP		protein stabilization				7543519	1	1	0		
NRF2	DNA binding protein; Transcription factor	Q16236	4780	NFE2L2	2q31	human	T559	PHOSPHORYLATION	10292701	LLKKQLStLYLEVFS		intracellular localization	transcription, induced			9983602	1	1	0	moderate effects observed only in NFE2L2-5A mutant	
MRE11A	Cell cycle regulation; DNA binding protein; DNA repair; Deoxyribonuclease	P49959	4361	MRE11A	11q21	human	T329	PHOSPHORYLATION	11506402	NPDNPKVtQAIQSFC	Mre11_DNA_bind	molecular association, regulation			DNA(DISRUPTS)	11484420	1	0	0		
WNK4	EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor)	Q80UE6	69847	Wnk4		mouse	S1169	PHOSPHORYLATION	477191	SCRQRRLsKGSFPTS		activity, inhibited				9360	5	1	0	WNK4 phosphorylation abrogates its basal inhibition of ENaC and ROMK channels	
PAR1	Cell development/differentiation; GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR	P25116	2149	F2R	5q13	human	S399	PHOSPHORYLATION	3627502	SDPSSYNsSGQLMAS		receptor desensitization, altered				4656	1	0	1	receptor shutoff (not internalization)	
EPRS	Cofactor and Vitamin Metabolism - porphyrin and chlorophyll; EC 6.1.1.15; EC 6.1.1.17; Ligase; Translation	P07814	2058	EPRS	1q41	human	S999	PHOSPHORYLATION	9720900	NQGGGLSsSGAGEGQ		molecular association, regulation	translation, altered	GAPDH(INDUCES); RPL13A(INDUCES)		9689600	3	2	0		
CRYAB	Chaperone	P23928	25420	Cryab		rat	S59	PHOSPHORYLATION	448783	PSFLRAPsWIDTGLS	Crystallin	intracellular localization; activity, inhibited	apoptosis, altered			5553; 1172833	32	14	0		
WAVE2	Actin binding protein; Motility/polarity/chemotaxis	Q8BH43	242687	Wasf2		mouse	Y150	PHOSPHORYLATION	455197	GKEALKFyTNPSYFF			cytoskeletal reorganization			2519605	3	0	0		
PLD2	EC 3.1.4.4; Lipid Metabolism - ether lipid; Lipid Metabolism - glycerophospholipid; Motility/polarity/chemotaxis; Phospholipase	O14939	5338	PLD2	17p13.1	human	Y179	PHOSPHORYLATION	458807	RLLTMSFyRNYHAMT	PX	molecular association, regulation; enzymatic activity, induced	cell motility, altered; cell growth, altered	CD45(DISRUPTS); Grb2(INDUCES)		7467; 15022725; 9985922	4	0	0		
5-HT(2C)	GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR	P08909	25187	Htr2c		rat	S459	PHOSPHORYLATION	449971	VVSERISsV______		receptor desensitization, altered				2122	2	0	0		
Bcl-6	C2H2-type zinc finger protein; Transcription factor	P41182	604	BCL6	3q27	human	S343	PHOSPHORYLATION	471422	KSDCQPNsPTESCSS		protein degradation				9139	1	2	19		
FRS2	Adaptor/scaffold	Q8C180	327826	Frs2		mouse	Y306	PHOSPHORYLATION	449783	PPVNKLVyENINGLS		molecular association, regulation		Grb2(INDUCES)		1356	2	9	169		
CAMK2D	EC 2.7.11.17; KINASE; Kinase, protein; Protein kinase, CAMK; Protein kinase, Ser/Thr (non-receptor)	P15791	24246	Camk2d		rat	T287	PHOSPHORYLATION	450982	SMMHRQEtVDCLKKF		enzymatic activity, induced	cell motility, altered			3246	7	17	131		
ROCK2	EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor)	Q28021	282041	ROCK2		cow	S1374	PHOSPHORYLATION	468651	MKIQQNQsIRRPSRQ		enzymatic activity, induced	cell cycle regulation			12177	2	8	1	alanine mutation of all 4 sites	
Ikaros	C2H2-type zinc finger protein; DNA binding protein; Transcription factor	Q03267	22778	Ikzf1		mouse	S13	PHOSPHORYLATION	4828300	GQDMSQVsGKESPPV		molecular association, regulation; intracellular localization			DNA(DISRUPTS)	4615812	1	0	0		
IP3R1	Channel, calcium; Channel, ligand-gated; Membrane protein, integral; Membrane protein, multi-pass; Receptor, misc.	P29994	25262	Itpr1		rat	S2682	PHOSPHORYLATION	458310	FPRMRAMsLVSSDSE		activity, inhibited				7375	1	1	1	staurosporin-induced caspase-3 activation was enhanced in cells expressing S2682A mutant IP3R1.	
Rb	Nuclear receptor co-regulator; Transcription, coactivator/corepressor; Tumor suppressor	P13405	19645	Rb1		mouse	T246	PHOSPHORYLATION	449821	PINGSPRtPRRGQNR		molecular association, regulation		E2F1(DISRUPTS)		1258	13	12	53		
PTEN	Carbohydrate Metabolism - inositol phosphate; EC 3.1.3.16; EC 3.1.3.48; EC 3.1.3.67; Motility/polarity/chemotaxis; Nuclear receptor co-regulator; PHOSPHATASE; Phosphatase, lipid; Tumor suppressor	P60484	5728	PTEN	10q23.3	human	T232	PHOSPHORYLATION	456214	YSSNSGPtRREDKFM	PTEN_C2		cell motility, altered			6062	1	1	1		
CTLA-4	Immunoglobulin superfamily; Membrane protein, integral	P09793	12477	Ctla4		mouse	Y218	PHOSPHORYLATION	450898	CEKQFQPyFIPIN__		molecular association, regulation		SHP-2(INDUCES)		3183	3	0	0		
MDM2	EC 6.3.2.-; EC 6.3.2.19; Inhibitor protein; Ligase; UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase	Q00987	4193	MDM2	12q14.3-q15	human	S429	PHOSPHORYLATION	11956707	KEESVESsLPLNAIE		molecular association, regulation; ubiquitination		MDM2(DISRUPTS)		11387267	2	1	0	phospho-mimic mutant is defective for p53 poly-ubiquitination	
MST1	Autophagy; EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, STE; Protein kinase, Ser/Thr (non-receptor)	Q9JI11	58231	Stk4		mouse	T183	PHOSPHORYLATION	447925	DTMAKRNtVIGTPFW	Pkinase	enzymatic activity, induced	cell adhesion, altered			2608	9	0	5		
HDAC5	EC 3.5.1.98; Hydrolase	Q9UQL6	10014	HDAC5	17q21	human	S278	PHOSPHORYLATION	4788482	QKVAERRsSPLLRRK		molecular association, regulation; enzymatic activity, induced		SMRT(INDUCES); N-CoR1(DISRUPTS); GPS2(INDUCES); HDAC3(INDUCES); TBL1X(INDUCES); TBL1XR1(INDUCES); 14-3-3 epsilon(DISRUPTS)		17431525; 25797200	2	8	0	S278/279A mutant shows a slight decrease in the deacetylation activity; reduced NCoR complex ( NCOR1, TBL1X, TBL1XR1) binding in mitotic cells allows for increased phosphorylation of this site by AurB	
SRC-3	ACETYLTRANSFERASE; Acetyltransferase; EC 2.3.1.48; Motility/polarity/chemotaxis; Nuclear receptor co-regulator; Transcription, coactivator/corepressor	Q9Y6Q9	8202	NCOA3	20q12	human	S505	PHOSPHORYLATION	454109	SPVAGVHsPMASSGN		molecular association, regulation		ER-alpha(DISRUPTS)		4214	5	0	0	Mutations to alanine inhibited protein-protein interactions. 	
TIE2	EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Protein kinase, TK; Protein kinase, tyrosine (receptor)	Q02858	21687	Tek		mouse	Y1111	PHOSPHORYLATION	450257	TLYEKFTyAGIDCSA		enzymatic activity, inhibited; protein conformation; phosphorylation				12021315	3	0	0	Y1113F mutation increases TIE2 phosphorylation and enhances downstream signaling	
HEMH	Cofactor and Vitamin Metabolism - porphyrin and chlorophyll; EC 4.99.1.1; Lyase; Mitochondrial	P22315	14151	Fech		mouse	S127	PHOSPHORYLATION	2048057	ERRIGGGsPIKMWTS	Ferrochelatase	enzymatic activity, induced				9985923	1	2	0		
MEF2A	DNA binding protein; Motility/polarity/chemotaxis; Transcription factor	Q02078	4205	MEF2A	15q26	human	S255	PHOSPHORYLATION	456757	GKVMPTKsPPPPGGG		protein degradation				6880	1	9	0		
DRD1	GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR	P18901	24316	Drd1		rat	S431	PHOSPHORYLATION	458340	LDYDTDVsLEKIQPV		receptor desensitization, altered; intracellular localization				7381	1	0	0		
Ron	EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Protein kinase, TK; Protein kinase, tyrosine (receptor)	Q62190	19882	Mst1r		mouse	Y1337	PHOSPHORYLATION	456488	YVQLTAAyVNVGPRA		enzymatic activity, induced	apoptosis, induced; cell growth, altered	Shc1(INDUCES); PLCG1(INDUCES); PIK3CA(INDUCES); Grb2(INDUCES)		6746; 6720	3	0	0		
Shc1	Adaptor/scaffold; Apoptosis; Mitochondrial; Motility/polarity/chemotaxis	P98083	20416	Shc1		mouse	Y350	PHOSPHORYLATION	448510	EPPDHQYyNDFPGKE		activity, induced; molecular association, regulation; phosphorylation	cell differentiation, altered	Grb2(INDUCES)		6563; 6347; 3053; 6039	24	14	919		
SOS1	Adaptor/scaffold; Guanine nucleotide exchange factor, Ras; Motility/polarity/chemotaxis	Q07889	6654	SOS1	2p21	human	S1167	PHOSPHORYLATION	451314	ESAPAESsPSKIMSK		molecular association, regulation		Grb2(DISRUPTS)		3524	1	1	1		
PLK4	EC 2.7.11.21; KINASE; Kinase, protein; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor)	Q64702	20873	Plk4		mouse	T292	PHOSPHORYLATION	12654007	SGHATLStTITASSG		protein degradation; ubiquitination				12525201	1	1	0		
ELK3	DNA binding protein; Transcription factor	P41971	13713	Elk3		mouse	S365	PHOSPHORYLATION	450032	LSPVAPLsPARLQGP		activity, induced; intracellular localization	transcription, altered; cell growth, altered			4317100; 1187	2	0	0	pro-B cell expansion	
FCP1	EC 3.1.3.16; Motility/polarity/chemotaxis; PHOSPHATASE; Protein phosphatase, Ser/Thr (non-receptor); Transcription initiation complex	Q9Y5B0	9150	CTDP1	18q23	human	S740	PHOSPHORYLATION	453872	TKAQRENsPAAFPDR	FCP1_C	molecular association, regulation; enzymatic activity, induced	transcription, induced	GTF2F2(INDUCES)		10296902	1	19	1		
CD3Z	Membrane protein, integral; Receptor, misc.	P20963	919	CD247	1q24.2	human	Y111	PHOSPHORYLATION	448933	KNPQEGLyNELQKDK	ITAM	intracellular localization				6115909	2	14	404		
SLAM	Membrane protein, integral; Receptor, misc.	Q9QUM4	27218	Slamf1		mouse	Y335	PHOSPHORYLATION	447634	EPNPTTVyASVTLPE	Sarcoglycan_2	molecular association, regulation		Fyn(INDUCES)		1376	3	0	0		
PPAR-alpha	DNA binding protein; Nuclear receptor	P37230	25747	Ppara		rat	S179	PHOSPHORYLATION	457549	RFGRMPRsEKAKLKA		activity, induced; molecular association, regulation	transcription, altered	RXRA(INDUCES)		7128	2	0	0		
Akt1	EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor)	P31749	207	AKT1	14q32.32	human	T308	PHOSPHORYLATION	447856	KDGATMKtFCGTPEY	Pkinase	activity, induced; molecular association, regulation; intracellular localization; protein conformation; phosphorylation; enzymatic activity, induced	cell cycle regulation; apoptosis, altered; carcinogenesis, induced; transcription, altered; apoptosis, inhibited; cell motility, altered; cytoskeletal reorganization; cell growth, altered	PPP2CA(INDUCES); PDK1(INDUCES); PAK1(INDUCES)		8639; 4534; 4861514; 6537; 4646606; 15658705; 4768; 5010612; 5424; 7228; 13788302; 847; 6541; 4646607; 5708; 5880; 25091300; 12735103; 3391008; 14148607; 6271026; 848; 6575; 5253; 7309805; 6782007; 12728100; 3394311; 5285; 462; 6752; 8911; 4461	462	2	12		
ACLY	Carbohydrate Metabolism - citrate (TCA) cycle; EC 2.3.3.8; Lyase; Transferase	Q91V92	104112	Acly		mouse	H750	PHOSPHORYLATION	9643000	SSEVQFGhAGACANQ	Ligase_CoA	enzymatic activity, induced				8068302	3	0	0	important for cell viability	
HCRTR1	GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR	O43613	3061	HCRTR1	1p33	human	Y83	PHOSPHORYLATION	10206803	HMRTVTNyFIVNLSL	Form_Nir_trans; 7tm_1; TM	molecular association, regulation	apoptosis, altered	SHP-2(INDUCES)		9980418	1	0	0		
ITGB4	Cell adhesion; Membrane protein, integral; Motility/polarity/chemotaxis; Receptor, misc.	P16144	3691	ITGB4	17q25	human	S1494	PHOSPHORYLATION	465821	TLTRDYNsLTRSEHS		intracellular localization				5354431	3	3	19	inhibits incorporation of ITGB4 into hemidesmosomes and promotes its disassembly	
Snail1	C2H2-type zinc finger protein; Transcription factor	O95863	6615	SNAI1	20q13.2	human	S111	PHOSPHORYLATION	6097705	SPPSPAPsSFSSTSV	CAP_N	intracellular localization	cell motility, altered; transcription, altered			6066701; 6098000	2	0	0	Localization mediated by S107, S111, S115 and S119. 	
Ets-2	DNA binding protein; Transcription factor	P15036	2114	ETS2	21q22.2	human	T72	PHOSPHORYLATION	447688	NCELPLLtPCSKAVM		activity, induced	transcription, induced; transcription, altered			2072; 20834151; 1696; 4894704	9	0	0	GSK3B transactivation 	
GluR2	Channel, calcium; Channel, ligand-gated; Membrane protein, integral; Membrane protein, multi-pass	P42262	2891	GRIA2	4q32.1	human	S880	PHOSPHORYLATION	448351	YNVYGIEsVKI____		activity, induced				7215	20	1	0	criticcal for induction of cerebellar long-term depression	
Src	EC 2.7.10.2; KINASE; Kinase, protein; Protein kinase, TK; Protein kinase, tyrosine (non-receptor)	P00523	396442	SRC		chicken	Y519	PHOSPHORYLATION	7445100	LQAFLEDyFTSTEPQ			cell growth, altered			791	5	0	0		
