mpath.owl
type: Ontology
version IRI: mpath.owl
namespace-id-rule: * MPATH:$sequence(3,0,999)$
auto-generated-by: OBO-Edit 2.3-beta5
default-namespace: mouse_pathology.ontology
has_obo_format_version: 1.2
saved-by: ORCID: 0000-0002-5111-7263
comment: The Pathbase mouse pathology ontology provides a description of experimental mouse pathology phenotypes and incorporates 889 concepts including anatomical pathological entities and pathological processes. These are organised in an almost entirely is_a hierarchy of pathological processes or anatomical entities. Questions, comments and suggestions for amendment should be sent to the Co-ordinator, Dr. Paul Schofield, Dept. of Physiology Development and Neuroscience, University of Cambridge (PNS12@cam.ac.uk).The ontology was developed by the Pathbase consortium (http://www.pathbase.net) funded under the European Commission's Fifth Framework programme, Contract number QLRI-CT-1999-00320.

definition
type: AnnotationProperty

namespace-id-rule
type: AnnotationProperty

has_alternative_id
type: AnnotationProperty

has_broad_synonym
type: AnnotationProperty

database_cross_reference
type: AnnotationProperty

has_exact_synonym
type: AnnotationProperty

has_obo_format_version
type: AnnotationProperty

has_obo_namespace
type: AnnotationProperty

has_related_synonym
type: AnnotationProperty

is a
type: ObjectProperty
has_obo_namespace: mouse_pathology.ontology
id: is_a

part of
type: ObjectProperty
type: TransitiveProperty
has_obo_namespace: mouse_pathology.ontology
id: part_of

pathological entity
type: Class
subclass of: pathological phenotype observation
definition: Pathological structure or process
has_obo_namespace: mouse_pathology.ontology
id: MPATH:0

Axiom
annotated source: pathological entity
annotated property: definition
annotated target: Pathological structure or process
database_cross_reference: Pathbase: Curation

cell and tissue damage
type: Class
subclass of: pathological anatomical entity
definition: The sum of morphological and functional disturbances induced by cell and tissue damage, either from intrinsic gene dysfunction or as a result of external factors.
has_obo_namespace: mouse_pathology.ontology
id: MPATH:1

Axiom
annotated source: cell and tissue damage
annotated property: definition
annotated target: The sum of morphological and functional disturbances induced by cell and tissue damage, either from intrinsic gene dysfunction or as a result of external factors.
database_cross_reference: Pathbase: Pathology Committee

gangrene
type: Class
subclass of: necrosis
definition: Extensive necrosis from whatever cause, often following chronic ischemia.
has_obo_namespace: mouse_pathology.ontology
has_related_synonym: Mortification
id: MPATH:10

Axiom
annotated source: gangrene
annotated property: definition
annotated target: Extensive necrosis from whatever cause, often following chronic ischemia.
database_cross_reference: ISBN:0781727286

Axiom
annotated source: gangrene
annotated property: has_related_synonym
annotated target: Mortification
database_cross_reference: Pathbase: Curation

placental abnormality
type: Class
subclass of: organ specific developmental defect
definition: Defect in placental growth, differentiation of circulation; maternal or embryonic component.
has_obo_namespace: mouse_pathology.ontology
id: MPATH:100

Axiom
annotated source: placental abnormality
annotated property: definition
annotated target: Defect in placental growth, differentiation of circulation; maternal or embryonic component.
database_cross_reference: Pathbase: Pathology Committee

pathological phenotype observation
type: Class
definition: Phenotypic observation of the presence or absence of a pathological entity.
created by: Luke Slater
has_obo_namespace: mouse_pathology.ontology
id: MPATH:1000

Axiom
annotated source: pathological phenotype observation
annotated property: definition
annotated target: Phenotypic observation of the presence or absence of a pathological entity.
database_cross_reference: UOB:LTS

glycogen cell defect
type: Class
subclass of: placental abnormality
definition: Lack of, displacement of, or abnormality in function or growth of the glycogen cells.
has_obo_namespace: mouse_pathology.ontology
id: MPATH:101

Axiom
annotated source: glycogen cell defect
annotated property: definition
annotated target: Lack of, displacement of, or abnormality in function or growth of the glycogen cells.
database_cross_reference: Pathbase: Curation

labyrinth zone defect
type: Class
subclass of: placental abnormality
definition: Defect in size, cellular composition, function or organisation of the labyrinthine zone of the placenta.
has_obo_namespace: mouse_pathology.ontology
id: MPATH:102

Axiom
annotated source: labyrinth zone defect
annotated property: definition
annotated target: Defect in size, cellular composition, function or organisation of the labyrinthine zone of the placenta.
database_cross_reference: Pathbase: Pathology Committee

placental vascular defect
type: Class
subclass of: placental abnormality
definition: Any defect in the maternal or embryonic placental circulation.
has_obo_namespace: mouse_pathology.ontology
id: MPATH:103

Axiom
annotated source: placental vascular defect
annotated property: definition
annotated target: Any defect in the maternal or embryonic placental circulation.
database_cross_reference: Pathbase: Curation

spongiotrophoblast defect
type: Class
subclass of: placental abnormality
definition: Defect in size, cellular composition, function or organisation of the spongiotrophoblast zone of the placenta.
has_obo_namespace: mouse_pathology.ontology
id: MPATH:104

Axiom
annotated source: spongiotrophoblast defect
annotated property: definition
annotated target: Defect in size, cellular composition, function or organisation of the spongiotrophoblast zone of the placenta.
database_cross_reference: Pathbase: Curation

circulatory disorder
type: Class
subclass of: pathological anatomical entity
definition: Lesions leading to or consequent on failure of, or atypical movement of, blood throughout the body.
has_obo_namespace: mouse_pathology.ontology
id: MPATH:105

Axiom
annotated source: circulatory disorder
annotated property: definition
annotated target: Lesions leading to or consequent on failure of, or atypical movement of, blood throughout the body.
database_cross_reference: Pathbase: Pathology Committee

fluid accumulation
type: Class
subclass of: circulatory disorder
definition: Abnormal accumulation of fluid; blood or lymph.
has_obo_namespace: mouse_pathology.ontology
id: MPATH:106

Axiom
annotated source: fluid accumulation
annotated property: definition
annotated target: Abnormal accumulation of fluid; blood or lymph.
database_cross_reference: Pathbase: Curation

congestion
type: Class
subclass of: fluid accumulation
definition: Presence of an abnormal amount of fluid (but especially of blood) in the vessels or passages of a part or organ.
has_obo_namespace: mouse_pathology.ontology
id: MPATH:107

Axiom
annotated source: congestion
annotated property: definition
annotated target: Presence of an abnormal amount of fluid (but especially of blood) in the vessels or passages of a part or organ.
database_cross_reference: Pathbase: Pathology Committee

disseminated intravascular coagulation
type: Class
subclass of: circulatory disorder
definition: A syndrome consequent to uncontrolled activation of blood clotting factors leading to disseminated platelet lysis, and fibrin deposition, ultimately leading to bleeding and necrosis as a consequence of inhibition of fibrin polymerisation by degradation products.
has_obo_namespace: mouse_pathology.ontology
has_related_synonym: DIC
id: MPATH:108
comment: Diagnosed by microthrombi in many organs.

Axiom
annotated source: disseminated intravascular coagulation
annotated property: definition
annotated target: A syndrome consequent to uncontrolled activation of blood clotting factors leading to disseminated platelet lysis, and fibrin deposition, ultimately leading to bleeding and necrosis as a consequence of inhibition of fibrin polymerisation by degradation products.
database_cross_reference: ISBN:0781727286

Axiom
annotated source: disseminated intravascular coagulation
annotated property: has_related_synonym
annotated target: DIC
database_cross_reference: Pathbase: Curation

edema
type: Class
subclass of: fluid accumulation
definition: An accumulation of an excessive amount of watery fluid in cells or intercellular tissues.
has_exact_synonym: oedema
has_obo_namespace: mouse_pathology.ontology
id: MPATH:109

Axiom
annotated source: edema
annotated property: definition
annotated target: An accumulation of an excessive amount of watery fluid in cells or intercellular tissues.
database_cross_reference: Pathbase: Curation

hemorrhagic necrosis
type: Class
subclass of: necrosis
definition: Necrosis associated with local hemorrhage.
has_obo_namespace: mouse_pathology.ontology
id: MPATH:11

Axiom
annotated source: hemorrhagic necrosis
annotated property: definition
annotated target: Necrosis associated with local hemorrhage.
database_cross_reference: ISBN:0781727286

embolus
type: Class
subclass of: circulatory disorder
definition: A plug formed from a variety of materials occluding a vessel or tube.
has_obo_namespace: mouse_pathology.ontology
id: MPATH:110

Axiom
annotated source: embolus
annotated property: definition
annotated target: A plug formed from a variety of materials occluding a vessel or tube.
database_cross_reference: Pathbase: Pathology Committee

air embolism
type: Class
subclass of: embolus
definition: An bubble of air occluding flow through a blood or lymphatic vessel.
has_obo_namespace: mouse_pathology.ontology
id: MPATH:111

Axiom
annotated source: air embolism
annotated property: definition
annotated target: An bubble of air occluding flow through a blood or lymphatic vessel.
database_cross_reference: Pathbase: Curation

amniotic fluid embolism
type: Class
subclass of: embolus
definition: Occlusion of vessels caused by entry of amniotic fluid, cell and debris into the maternal circulation.
has_obo_namespace: mouse_pathology.ontology
id: MPATH:112

Axiom
annotated source: amniotic fluid embolism
annotated property: definition
annotated target: Occlusion of vessels caused by entry of amniotic fluid, cell and debris into the maternal circulation.
database_cross_reference: Pathbase: Curation

atrial embolism
type: Class
subclass of: embolus
definition: Occlusion of the outflow tract of the right atrium by a thrombus.
has_obo_namespace: mouse_pathology.ontology
id: MPATH:113

Axiom
annotated source: atrial embolism
annotated property: definition
annotated target: Occlusion of the outflow tract of the right atrium by a thrombus.
database_cross_reference: Pathbase: Curation

bone marrow embolism
type: Class
subclass of: embolus
definition: Occlusion of vessels caused by entry of bone marrow, often fatty debris into the circulation. Usually following trauma.
has_obo_namespace: mouse_pathology.ontology
id: MPATH:114

Axiom
annotated source: bone marrow embolism
annotated property: definition
annotated target: Occlusion of vessels caused by entry of bone marrow, often fatty debris into the circulation. Usually following trauma.
database_cross_reference: Pathbase: Pathology Committee

fat embolism
type: Class
subclass of: embolus
definition: Occlusion of vessels caused by entry of lipid or fatty cells into the circulation. Usually following trauma.
has_obo_namespace: mouse_pathology.ontology
id: MPATH:115

Axiom
annotated source: fat embolism
annotated property: definition
annotated target: Occlusion of vessels caused by entry of lipid or fatty cells into the circulation. Usually following trauma.
database_cross_reference: Pathbase: Curation

pulmonary embolism
type: Class
subclass of: embolus
definition: Occlusion of pulmonary vessels by an embolus.
has_obo_namespace: mouse_pathology.ontology
id: MPATH:116

Axiom
annotated source: pulmonary embolism
annotated property: definition
annotated target: Occlusion of pulmonary vessels by an embolus.
database_cross_reference: Pathbase: Curation

skin embolism
type: Class
subclass of: embolus
definition: Occlusion of vessels, usually small arterioles in the dermis by various emboli.
has_obo_namespace: mouse_pathology.ontology
id: MPATH:117

Axiom
annotated source: skin embolism
annotated property: definition
annotated target: Occlusion of vessels, usually small arterioles in the dermis by various emboli.
database_cross_reference: Pathbase: Curation

systemic embolism
type: Class
subclass of: embolus
definition: Production of systemic vessel occlusion by emboli released from the left side of the heart, or the aorta.
has_obo_namespace: mouse_pathology.ontology
id: MPATH:118

Axiom
annotated source: systemic embolism
annotated property: definition
annotated target: Production of systemic vessel occlusion by emboli released from the left side of the heart, or the aorta.
database_cross_reference: Pathbase: Pathology Committee

hemorrhage and non-specified extravasation
type: Class
subclass of: circulatory disorder
definition: Abnormal release of whole blood or the cellular component from the circulation.
has_obo_namespace: mouse_pathology.ontology
id: MPATH:119

Axiom
annotated source: hemorrhage and non-specified extravasation
annotated property: definition
annotated target: Abnormal release of whole blood or the cellular component from the circulation.
database_cross_reference: Pathbase: Curation

liquefactive necrosis
type: Class
subclass of: necrosis
definition: Soft or fluid tissue remains of a circumscribed area of necrosis digested by proteolytic enzymes.
has_obo_namespace: mouse_pathology.ontology
id: MPATH:12

Axiom
annotated source: liquefactive necrosis
annotated property: definition
annotated target: Soft or fluid tissue remains of a circumscribed area of necrosis digested by proteolytic enzymes.
database_cross_reference: ISBN:0781727286

ecchymosis
type: Class
subclass of: hemorrhage and non-specified extravasation
definition: A red/purple patch caused by extravasation of blood into the skin. Larger than petechiae.
has_obo_namespace: mouse_pathology.ontology
id: MPATH:120
comment: May also be used for any organ, although more generally used with respect to the skin.

Axiom
annotated source: ecchymosis
annotated property: definition
annotated target: A red/purple patch caused by extravasation of blood into the skin. Larger than petechiae.
database_cross_reference: ISBN:0781727286

hematoma
type: Class
subclass of: hemorrhage and non-specified extravasation
definition: A localised deposition of clotted or partially clotted extravasated blood.
has_obo_namespace: mouse_pathology.ontology
has_related_synonym: Bruise
id: MPATH:121

Axiom
annotated source: hematoma
annotated property: definition
annotated target: A localised deposition of clotted or partially clotted extravasated blood.
database_cross_reference: ISBN:0781727286

Axiom
annotated source: hematoma
annotated property: has_related_synonym
annotated target: Bruise
database_cross_reference: Pathbase: Curation

petechia
type: Class
subclass of: hemorrhage and non-specified extravasation
definition: Small hemorrhagic spots in the skin caused by blood vessel breakdown.
has_obo_namespace: mouse_pathology.ontology
id: MPATH:122
comment: Usually used with reference to the skin but can be used in the context of other organs.

Axiom
annotated source: petechia
annotated property: definition
annotated target: Small hemorrhagic spots in the skin caused by blood vessel breakdown.
database_cross_reference: ISBN:0781727286

purpura
type: Class
subclass of: hemorrhage and non-specified extravasation
definition: Purple and variously colored lesions caused by extensive haemorrhage into the skin through ecchymoses/petechia.
has_obo_namespace: mouse_pathology.ontology
id: MPATH:123

Axiom
annotated source: purpura
annotated property: definition
annotated target: Purple and variously colored lesions caused by extensive haemorrhage into the skin through ecchymoses/petechia.
database_cross_reference: ISBN:0781727286

infarct
type: Class
subclass of: circulatory disorder
definition: An area of necrosis resulting from a sudden cessation of arterial or venous blood supply.
has_obo_namespace: mouse_pathology.ontology
id: MPATH:124

Axiom
annotated source: infarct
annotated property: definition
annotated target: An area of necrosis resulting from a sudden cessation of arterial or venous blood supply.
database_cross_reference: Pathbase: Pathology Committee

thrombosis
type: Class
subclass of: circulatory disorder
definition: Presence of an occluding or mural thrombus in a blood vessel.
has_obo_namespace: mouse_pathology.ontology
id: MPATH:125

Axiom
annotated source: thrombosis
annotated property: definition
annotated target: Presence of an occluding or mural thrombus in a blood vessel.
database_cross_reference: Pathbase: Curation

growth and differentiation defect
type: Class
subclass of: pathological anatomical entity
definition: Defects in growth (changes in proliferation or mass) and differentiation of cells tissues or organs.
has_obo_namespace: mouse_pathology.ontology
id: MPATH:126

Axiom
annotated source: growth and differentiation defect
annotated property: definition
annotated target: Defects in growth (changes in proliferation or mass) and differentiation of cells tissues or organs.
database_cross_reference: Pathbase: Pathology Committee

atrophy
type: Class
subclass of: defective growth and differentiation process
definition: A reduction in size of organs or tissues as a result of cell death, loss of cellularity of whatever cause, reduced cellular proliferation or decreased cellular volume.
has_obo_namespace: mouse_pathology.ontology
id: MPATH:127

Axiom
annotated source: atrophy
annotated property: definition
annotated target: A reduction in size of organs or tissues as a result of cell death, loss of cellularity of whatever cause, reduced cellular proliferation or decreased cellular volume.
database_cross_reference: Pathbase: Pathology Committee

intra-epithelial neoplasia
type: Class
subclass of: potentially cancerous lesions
definition: Non-invasive changes characterized by alteration in the size, shape and organization of the cellular components of an epithelial tissue. Do not confuse with developmental dysplasia MPATH:64.
has_obo_namespace: mouse_pathology.ontology
has_related_synonym: intra-epithelial lesion
id: MPATH:128
comment: This term has been previously used as a synonym for pre-malignant dysplasia or carcinoma in situ and is now to be preferred.

Axiom
annotated source: intra-epithelial neoplasia
annotated property: definition
annotated target: Non-invasive changes characterized by alteration in the size, shape and organization of the cellular components of an epithelial tissue. Do not confuse with developmental dysplasia MPATH:64.
database_cross_reference: Journal: Ward; J.M. ( 2002) J Toxicol. Pathol. 15; 123-128

Axiom
annotated source: intra-epithelial neoplasia
annotated property: has_related_synonym
annotated target: intra-epithelial lesion
database_cross_reference: Pathbase: Curation

epithelial dysplasia
type: Class
definition: epithelial dysplasia
has_obo_namespace: mouse_pathology.ontology
id: MPATH:129
comment: obsolete due to renaming of preneoplastic dysplasias and Intraepithelial neoplasias Use MPATH:128.
deprecated: true

Axiom
annotated source: epithelial dysplasia
annotated property: definition
annotated target: epithelial dysplasia
database_cross_reference: Pathbase: Pathology Committee

piecemeal necrosis
type: Class
subclass of: necrosis
definition: Sensu; hepaticobiliary system. Loss and degeneration of hepatocytes at the portal-lobular interface producing a moth-eaten irregular appearance. Piecemeal necrosis is associated with a lymphocytic infiltrate.
has_obo_namespace: mouse_pathology.ontology
id: MPATH:13

Axiom
annotated source: piecemeal necrosis
annotated property: definition
annotated target: Sensu; hepaticobiliary system. Loss and degeneration of hepatocytes at the portal-lobular interface producing a moth-eaten irregular appearance. Piecemeal necrosis is associated with a lymphocytic infiltrate.
database_cross_reference: ISBN:0781727286

mild intra-epithelial neoplasia
type: Class
subclass of: intra-epithelial neoplasia
definition: Mild non-invasive changes in cell morphology and tissue architecture confined to the epithelium alone.
created by: George Gkoutos
has_obo_namespace: mouse_pathology.ontology
has_related_synonym: IENI
has_related_synonym: low grade intraepithelial lesion
has_related_synonym: mild epithelial dysplasia.
id: MPATH:130

Axiom
annotated source: mild intra-epithelial neoplasia
annotated property: definition
annotated target: Mild non-invasive changes in cell morphology and tissue architecture confined to the epithelium alone.
database_cross_reference: Journal: Ward; J.M. ( 2002) J Toxicol. Pathol. 15; 123-128

Axiom
annotated source: mild intra-epithelial neoplasia
annotated property: has_related_synonym
annotated target: IENI
database_cross_reference: Pathbase: Curation

Axiom
annotated source: mild intra-epithelial neoplasia
annotated property: has_related_synonym
annotated target: low grade intraepithelial lesion
database_cross_reference: Pathbase: Curation

Axiom
annotated source: mild intra-epithelial neoplasia
annotated property: has_related_synonym
annotated target: mild epithelial dysplasia.
database_cross_reference: Pathbase: Curation

moderate intra-epithelial epithelial neoplasia
type: Class
subclass of: intra-epithelial neoplasia
definition: Moderate non-invasive changes in cell morphology and tissue architecture confined to the epithelium alone.
created by: George Gkoutos
has_obo_namespace: mouse_pathology.ontology
has_related_synonym: IENII
has_related_synonym: high grade intraepithelial lesion
has_related_synonym: moderate epithelial dysplasia
id: MPATH:131

Axiom
annotated source: moderate intra-epithelial epithelial neoplasia
annotated property: definition
annotated target: Moderate non-invasive changes in cell morphology and tissue architecture confined to the epithelium alone.
database_cross_reference: Journal: Ward; J.M. ( 2002) J Toxicol. Pathol. 15; 123-128

Axiom
annotated source: moderate intra-epithelial epithelial neoplasia
annotated property: has_related_synonym
annotated target: IENII
database_cross_reference: Pathbase: Curation

Axiom
annotated source: moderate intra-epithelial epithelial neoplasia
annotated property: has_related_synonym
annotated target: high grade intraepithelial lesion
database_cross_reference: Pathbase: Curation

Axiom
annotated source: moderate intra-epithelial epithelial neoplasia
annotated property: has_related_synonym
annotated target: moderate epithelial dysplasia
database_cross_reference: Pathbase: Curation

severe intra-epithelial neoplasia
type: Class
subclass of: intra-epithelial neoplasia
definition: Severe non-invasive malignancy associated changes in cell morphology and tissue architecture confined to the epithelium alone.
created by: George Gkoutos
has_obo_namespace: mouse_pathology.ontology
has_related_synonym: IENIII
has_related_synonym: carcinoma in situ
has_related_synonym: high grade intra-epithelial lesion
has_related_synonym: severe epithelial dysplasia
id: MPATH:132
comment: Carcinoma in situ may be used in some systems as a synonym.

Axiom
annotated source: severe intra-epithelial neoplasia
annotated property: definition
annotated target: Severe non-invasive malignancy associated changes in cell morphology and tissue architecture confined to the epithelium alone.
database_cross_reference: Journal: Ward; J.M. ( 2002) J Toxicol. Pathol. 15; 123-128

Axiom
annotated source: severe intra-epithelial neoplasia
annotated property: has_related_synonym
annotated target: IENIII
database_cross_reference: Pathbase: Curation

Axiom
annotated source: severe intra-epithelial neoplasia
annotated property: has_related_synonym
annotated target: carcinoma in situ
database_cross_reference: Pathbase: Curation

Axiom
annotated source: severe intra-epithelial neoplasia
annotated property: has_related_synonym
annotated target: high grade intra-epithelial lesion
database_cross_reference: Pathbase: Curation

Axiom
annotated source: severe intra-epithelial neoplasia
annotated property: has_related_synonym
annotated target: severe epithelial dysplasia
database_cross_reference: Pathbase: Curation

hypoplasia
type: Class
subclass of: defective growth and differentiation process
definition: Small organ or structure; failure to develop to normal size.
created by: George Gkoutos
has_obo_namespace: mouse_pathology.ontology
has_related_synonym: Developmental hypoplasia
id: MPATH:133

Axiom
annotated source: hypoplasia
annotated property: definition
annotated target: Small organ or structure; failure to develop to normal size.
database_cross_reference: Pathbase: Pathology Committee

Axiom
annotated source: hypoplasia
annotated property: has_related_synonym
annotated target: Developmental hypoplasia
database_cross_reference: Pathbase: Curation

hyperplasia
type: Class
subclass of: defective growth and differentiation process
definition: An increase in cell numbers in comparison to normal as a consequence of increased cell proliferation. Non -neoplastic process.
created by: George Gkoutos
has_obo_namespace: mouse_pathology.ontology
id: MPATH:134

Axiom
annotated source: hyperplasia
annotated property: definition
annotated target: An increase in cell numbers in comparison to normal as a consequence of increased cell proliferation. Non -neoplastic process.
database_cross_reference: Pathbase: Pathology Committee

epithelial and stromal hyperplasia
type: Class
subclass of: hyperplastic tissue
definition: Abnormal proliferation of epithelial and stromal cells.
created by: George Gkoutos
has_obo_namespace: mouse_pathology.ontology
id: MPATH:135

Axiom
annotated source: epithelial and stromal hyperplasia
annotated property: definition
annotated target: Abnormal proliferation of epithelial and stromal cells.
database_cross_reference: Pathbase: Pathology Committee

fibroepithelial polyp
type: Class
subclass of: epithelial hyperplasia
definition: A polypoid outgrowth of both epidermis and dermal fibrovascular tissue.
created by: George Gkoutos
has_obo_namespace: mouse_pathology.ontology
has_related_synonym: skin tag
id: MPATH:136

Axiom
annotated source: fibroepithelial polyp
annotated property: definition
annotated target: A polypoid outgrowth of both epidermis and dermal fibrovascular tissue.
database_cross_reference: ISBN:0781727286

Axiom
annotated source: fibroepithelial polyp
annotated property: has_related_synonym
annotated target: skin tag
database_cross_reference: Pathbase: Curation

fibroglandular hyperplasia
type: Class
subclass of: epithelial and stromal hyperplasia
definition: Benign proliferation of glandular epithelium accompanied by proliferation of fibroblastic stroma.
created by: George Gkoutos
has_obo_namespace: mouse_pathology.ontology
id: MPATH:137

Axiom
annotated source: fibroglandular hyperplasia
annotated property: definition
annotated target: Benign proliferation of glandular epithelium accompanied by proliferation of fibroblastic stroma.
database_cross_reference: Pathbase: Curation

epithelial hyperplasia
type: Class
subclass of: hyperplastic tissue
definition: Abnormal proliferation of epithelial cells and epithelial components.
created by: George Gkoutos
has_obo_namespace: mouse_pathology.ontology
id: MPATH:138

Axiom
annotated source: epithelial hyperplasia
annotated property: definition
annotated target: Abnormal proliferation of epithelial cells and epithelial components.
database_cross_reference: Pathbase: Pathology Committee

goblet cell hyperplasia
type: Class
subclass of: epithelial hyperplasia
definition: Benign proliferation of goblet cells.
created by: George Gkoutos
has_obo_namespace: mouse_pathology.ontology
id: MPATH:139

Axiom
annotated source: goblet cell hyperplasia
annotated property: definition
annotated target: Benign proliferation of goblet cells.
database_cross_reference: Pathbase: Curation

process of degenerative change
type: Class
subclass of: cell and tissue damage process
definition: A pathological process of loss or degradation of function, or structural integrity, of a tissue, organ or cell.
created by: George Gkoutos
has_obo_namespace: mouse_pathology.ontology
id: MPATH:14

Axiom
annotated source: process of degenerative change
annotated property: definition
annotated target: A pathological process of loss or degradation of function, or structural integrity, of a tissue, organ or cell.
database_cross_reference: Pathbase: Pathology Committee

hyperplastic polyp
type: Class
subclass of: polyp
definition: A benign polyp, usually in the colon, showing hyperplasia.
created by: George Gkoutos
has_obo_namespace: mouse_pathology.ontology
id: MPATH:140

Axiom
annotated source: hyperplastic polyp
annotated property: definition
annotated target: A benign polyp, usually in the colon, showing hyperplasia.
database_cross_reference: ISBN:0781727286

inflammatory polyp
type: Class
subclass of: polyp
definition: A projecting mass of granulation tissue which may become covered by regenerating epithelium.
created by: George Gkoutos
has_obo_namespace: mouse_pathology.ontology
has_related_synonym: pseudopolyp
id: MPATH:141

Axiom
annotated source: inflammatory polyp
annotated property: definition
annotated target: A projecting mass of granulation tissue which may become covered by regenerating epithelium.
database_cross_reference: ISBN:0781727286

Axiom
annotated source: inflammatory polyp
annotated property: has_related_synonym
annotated target: pseudopolyp
database_cross_reference: Pathbase: Curation

intraductal hyperplasia
type: Class
subclass of: epithelial hyperplasia
definition: Benign hyperplasia of the ducts of the mammary gland. Ducts exhibit more than the usual two layer epithelium (inner cuboidal to columnar cells; outer layer of myoepithelium) without cytological atypia.
created by: George Gkoutos
has_obo_namespace: mouse_pathology.ontology
id: MPATH:142

Axiom
annotated source: intraductal hyperplasia
annotated property: definition
annotated target: Benign hyperplasia of the ducts of the mammary gland. Ducts exhibit more than the usual two layer epithelium (inner cuboidal to columnar cells; outer layer of myoepithelium) without cytological atypia.
database_cross_reference: PMID:10713680

microglandular hyperplasia
type: Class
subclass of: epithelial hyperplasia
definition: Benign proliferation of glandular epithelia, eg. Endocervical glands. Consists of tightly packed glandular or tubular units, which vary in size, lined by a flattened-to-cuboidal epithelium.
created by: George Gkoutos
has_obo_namespace: mouse_pathology.ontology
has_related_synonym: microglandular adenosis
id: MPATH:143

Axiom
annotated source: microglandular hyperplasia
annotated property: definition
annotated target: Benign proliferation of glandular epithelia, eg. Endocervical glands. Consists of tightly packed glandular or tubular units, which vary in size, lined by a flattened-to-cuboidal epithelium.
database_cross_reference: ISBN:0781727286

Axiom
annotated source: microglandular hyperplasia
annotated property: has_related_synonym
annotated target: microglandular adenosis
database_cross_reference: Pathbase: Curation

myoepithelial hyperplasia
type: Class
subclass of: epithelial hyperplasia
definition: Benign proliferation of glandular myoepithelial cells.
created by: George Gkoutos
has_obo_namespace: mouse_pathology.ontology
id: MPATH:144

Axiom
annotated source: myoepithelial hyperplasia
annotated property: definition
annotated target: Benign proliferation of glandular myoepithelial cells.
database_cross_reference: Pathbase: Curation

fat cell hyperplasia
type: Class
subclass of: hyperplastic tissue
definition: Benign proliferation of adipose tissue.
created by: George Gkoutos
has_obo_namespace: mouse_pathology.ontology
id: MPATH:145

Axiom
annotated source: fat cell hyperplasia
annotated property: definition
annotated target: Benign proliferation of adipose tissue.
database_cross_reference: Pathbase: Pathology Committee

MPATH 146
type: Class
IAO_0000231: IAO_0000227
IAO_0100001: histiocytosis
deprecated: true

lymphoid hyperplasia
type: Class
subclass of: hyperplastic tissue
definition: Benign enlargement of lymphoid tissues.
created by: George Gkoutos
has_obo_namespace: mouse_pathology.ontology
has_related_synonym: lymphoid hypertrophy
id: MPATH:147

Axiom
annotated source: lymphoid hyperplasia
annotated property: definition
annotated target: Benign enlargement of lymphoid tissues.
database_cross_reference: Pathbase: Pathology Committee

Axiom
annotated source: lymphoid hyperplasia
annotated property: has_related_synonym
annotated target: lymphoid hypertrophy
database_cross_reference: Pathbase: Curation

mesothelial hyperplasia
type: Class
subclass of: hyperplastic tissue
definition: Benign proliferation of mesothelial cells lining body cavities presenting as small solid cell clusters or multiple layers with columnar morphology and delicate eosinophilic cytoplasm.
created by: George Gkoutos
has_obo_namespace: mouse_pathology.ontology
has_related_synonym: mesothelioma
id: MPATH:148

Axiom
annotated source: mesothelial hyperplasia
annotated property: definition
annotated target: Benign proliferation of mesothelial cells lining body cavities presenting as small solid cell clusters or multiple layers with columnar morphology and delicate eosinophilic cytoplasm.
database_cross_reference: Pathbase: Mohr

Axiom
annotated source: mesothelial hyperplasia
annotated property: has_related_synonym
annotated target: mesothelioma
database_cross_reference: Pathbase: Curation

squamous hyperplasia
type: Class
subclass of: hyperplastic tissue
definition: Benign proliferation of epidermal cells with hyperkeratosis. Variable growth pattern, regular to papillary (exophytic squamous cell hyperplasia).
created by: George Gkoutos
has_obo_namespace: mouse_pathology.ontology
has_related_synonym: epidermal hyperplasia.
has_related_synonym: squamous cell hyperplasia
id: MPATH:149

Axiom
annotated source: squamous hyperplasia
annotated property: definition
annotated target: Benign proliferation of epidermal cells with hyperkeratosis. Variable growth pattern, regular to papillary (exophytic squamous cell hyperplasia).
database_cross_reference: Pathbase: Pathology Committee

Axiom
annotated source: squamous hyperplasia
annotated property: has_related_synonym
annotated target: epidermal hyperplasia.
database_cross_reference: Pathbase: Curation

Axiom
annotated source: squamous hyperplasia
annotated property: has_related_synonym
annotated target: squamous cell hyperplasia
database_cross_reference: Pathbase: Curation

general degenerative process
type: Class
subclass of: process of degenerative change
definition: Change of tissue to a lower state of integrity or less functional form, as in heart failure.
created by: George Gkoutos
has_obo_namespace: mouse_pathology.ontology
id: MPATH:15

Axiom
annotated source: general degenerative process
annotated property: definition
annotated target: Change of tissue to a lower state of integrity or less functional form, as in heart failure.
database_cross_reference: Pathbase: Pathology Committee

acanthosis
type: Class
subclass of: squamous hyperplasia
definition: Hyperplasia of the Malpighian layer (prickle cell) of the epidermis.
created by: George Gkoutos
has_obo_namespace: mouse_pathology.ontology
id: MPATH:150

Axiom
annotated source: acanthosis
annotated property: definition
annotated target: Hyperplasia of the Malpighian layer (prickle cell) of the epidermis.
database_cross_reference: ISBN:0781727286

actinic keratosis
type: Class
subclass of: squamous hyperplasia
subclass of: potentially cancerous lesions
definition: Discrete, flat or elevated, verrucous, keratotic lesions. Epidermal changes are characterized by acanthosis, parakeratosis, and dyskeratoses. Dysplastic change is present and the keratinocytes vary in size and shape. Associated with UV exposure in humans. Not defined in mice to date.
created by: George Gkoutos
has_obo_namespace: mouse_pathology.ontology
id: MPATH:151

Axiom
annotated source: actinic keratosis
annotated property: definition
annotated target: Discrete, flat or elevated, verrucous, keratotic lesions. Epidermal changes are characterized by acanthosis, parakeratosis, and dyskeratoses. Dysplastic change is present and the keratinocytes vary in size and shape. Associated with UV exposure in humans. Not defined in mice to date.
database_cross_reference: Pathbase: Pathology Committee

basal cell hyperplasia
type: Class
subclass of: squamous hyperplasia
definition: Benign proliferation of the basal layer cells of the skin.
created by: George Gkoutos
has_obo_namespace: mouse_pathology.ontology
id: MPATH:152

Axiom
annotated source: basal cell hyperplasia
annotated property: definition
annotated target: Benign proliferation of the basal layer cells of the skin.
database_cross_reference: Pathbase: Curation

hypergranulosis
type: Class
subclass of: squamous hyperplasia
definition: Increased thickness of the granular layer of a stratified squamous epithelium, associated with hyperorthokeratosis.
created by: George Gkoutos
has_obo_namespace: mouse_pathology.ontology
id: MPATH:153

Axiom
annotated source: hypergranulosis
annotated property: definition
annotated target: Increased thickness of the granular layer of a stratified squamous epithelium, associated with hyperorthokeratosis.
database_cross_reference: Pathbase: Pathology Committee

hyperkeratosis
type: Class
subclass of: squamous hyperplasia
definition: Thickening of the surface layers (stratum corneum) in the skin or other stratified squamous epithelium. Cf. ortho- and para-keratosis.
created by: George Gkoutos
has_obo_namespace: mouse_pathology.ontology
has_related_synonym: cornification
has_related_synonym: hyperorthokeratosis
has_related_synonym: hyperparakeratosis
id: MPATH:154

Axiom
annotated source: hyperkeratosis
annotated property: definition
annotated target: Thickening of the surface layers (stratum corneum) in the skin or other stratified squamous epithelium. Cf. ortho- and para-keratosis.
database_cross_reference: Pathbase: Pathology Committee

Axiom
annotated source: hyperkeratosis
annotated property: has_related_synonym
annotated target: cornification
database_cross_reference: Pathbase: Curation

Axiom
annotated source: hyperkeratosis
annotated property: has_related_synonym
annotated target: hyperorthokeratosis
database_cross_reference: Pathbase: Curation

Axiom
annotated source: hyperkeratosis
annotated property: has_related_synonym
annotated target: hyperparakeratosis
database_cross_reference: Pathbase: Curation

orthokeratosis
type: Class
subclass of: hyperkeratosis
definition: Thickening of the anuclear cell layer limited to the stratum corneum, as in a stratified squamous epithelium.
created by: George Gkoutos
has_obo_namespace: mouse_pathology.ontology
id: MPATH:155

Axiom
annotated source: orthokeratosis
annotated property: definition
annotated target: Thickening of the anuclear cell layer limited to the stratum corneum, as in a stratified squamous epithelium.
database_cross_reference: Pathbase: Pathology Committee

parakeratosis
type: Class
subclass of: hyperkeratosis
definition: Thickening of the surface cell layer of a stratified squamous epithelium with retention of nuclei in the cells of the stratum corneum.
created by: George Gkoutos
has_obo_namespace: mouse_pathology.ontology
id: MPATH:156

Axiom
annotated source: parakeratosis
annotated property: definition
annotated target: Thickening of the surface cell layer of a stratified squamous epithelium with retention of nuclei in the cells of the stratum corneum.
database_cross_reference: Pathbase: Pathology Committee

pseudoepithelioma/pseudocarcinoma
type: Class
subclass of: squamous hyperplasia
definition: Benign hyperplasia and down-growth of epidermal cells. Microscopically resembling well-differentiated squamous cell carcinoma.
created by: George Gkoutos
has_obo_namespace: mouse_pathology.ontology
has_related_synonym: pseudocarcinoma
has_related_synonym: pseudocarcinomatous hyperplasia
has_related_synonym: pseudoepitheliomatous hyperplasia
id: MPATH:157

Axiom
annotated source: pseudoepithelioma/pseudocarcinoma
annotated property: definition
annotated target: Benign hyperplasia and down-growth of epidermal cells. Microscopically resembling well-differentiated squamous cell carcinoma.
database_cross_reference: ISBN:0781727286

Axiom
annotated source: pseudoepithelioma/pseudocarcinoma
annotated property: has_related_synonym
annotated target: pseudocarcinoma
database_cross_reference: Pathbase: Curation

Axiom
annotated source: pseudoepithelioma/pseudocarcinoma
annotated property: has_related_synonym
annotated target: pseudocarcinomatous hyperplasia
database_cross_reference: Pathbase: Curation

Axiom
annotated source: pseudoepithelioma/pseudocarcinoma
annotated property: has_related_synonym
annotated target: pseudoepitheliomatous hyperplasia
database_cross_reference: Pathbase: Curation

seborrheic keratosis
type: Class
subclass of: squamous hyperplasia
definition: Superficial, benign, verrucous, often pigmented, greasy lesions consisting of proliferating epidermal cells, resembling basal cells, enclosing cornifying cysts.
created by: George Gkoutos
has_obo_namespace: mouse_pathology.ontology
has_related_synonym: Basal cell papilloma
has_related_synonym: seborrheic verruca
id: MPATH:158

Axiom
annotated source: seborrheic keratosis
annotated property: definition
annotated target: Superficial, benign, verrucous, often pigmented, greasy lesions consisting of proliferating epidermal cells, resembling basal cells, enclosing cornifying cysts.
database_cross_reference: ISBN:0781727286

Axiom
annotated source: seborrheic keratosis
annotated property: has_related_synonym
annotated target: Basal cell papilloma
database_cross_reference: Pathbase: Curation

Axiom
annotated source: seborrheic keratosis
annotated property: has_related_synonym
annotated target: seborrheic verruca
database_cross_reference: Pathbase: Curation

hypertrophy
type: Class
subclass of: defective growth and differentiation process
definition: Increase in size or mass of a cell, tissue or organ without increase in cell proliferation. Cf. Hyperplasia MPATH: 133.
created by: George Gkoutos
has_obo_namespace: mouse_pathology.ontology
id: MPATH:159

Axiom
annotated source: hypertrophy
annotated property: definition
annotated target: Increase in size or mass of a cell, tissue or organ without increase in cell proliferation. Cf. Hyperplasia MPATH: 133.
database_cross_reference: Pathbase: Pathology Committee

myxoid/myxomatous degeneration
type: Class
subclass of: general degenerative process
definition: A conversion of the connective tissues into a gelatinous or mucous substance.
created by: George Gkoutos
has_obo_namespace: mouse_pathology.ontology
has_related_synonym: Mucoid degeneration
has_related_synonym: myxomatosis
id: MPATH:16

Axiom
annotated source: myxoid/myxomatous degeneration
annotated property: has_related_synonym
annotated target: Mucoid degeneration
database_cross_reference: Pathbase: Curation

Axiom
annotated source: myxoid/myxomatous degeneration
annotated property: has_related_synonym
annotated target: myxomatosis
database_cross_reference: Pathbase: Curation

Axiom
annotated source: myxoid/myxomatous degeneration
annotated property: definition
annotated target: A conversion of the connective tissues into a gelatinous or mucous substance.
database_cross_reference: ISBN:0781727286

metaplasia
type: Class
subclass of: defective growth and differentiation process
definition: Abnormal transformation of an fully differentiated adult cell or tissue of one kind into a differentiated tissue of another kind. An adult instance of developmental transdifferentiation MPATH:85 Traditionally defined as a form of abnormal regeneration in which a type of cell different from that found normally in a given location is produced.
created by: George Gkoutos
has_obo_namespace: mouse_pathology.ontology
id: MPATH:160

Axiom
annotated source: metaplasia
annotated property: definition
annotated target: Abnormal transformation of an fully differentiated adult cell or tissue of one kind into a differentiated tissue of another kind. An adult instance of developmental transdifferentiation MPATH:85 Traditionally defined as a form of abnormal regeneration in which a type of cell different from that found normally in a given location is produced.
database_cross_reference: Pathbase: Pathology Committee

cartilaginous metaplasia
type: Class
subclass of: metaplastic tissue
definition: Metaplasia resulting in heterotopic formation of cartilage.
created by: George Gkoutos
has_obo_namespace: mouse_pathology.ontology
id: MPATH:161

Axiom
annotated source: cartilaginous metaplasia
annotated property: definition
annotated target: Metaplasia resulting in heterotopic formation of cartilage.
database_cross_reference: ISBN:0781727286

epithelial metaplasia
type: Class
subclass of: metaplastic tissue
definition: Metaplasia occurring within epithelia.
created by: George Gkoutos
has_obo_namespace: mouse_pathology.ontology
id: MPATH:162

Axiom
annotated source: epithelial metaplasia
annotated property: definition
annotated target: Metaplasia occurring within epithelia.
database_cross_reference: ISBN:0781727286

apocrine metaplasia
type: Class
subclass of: epithelial metaplasia
definition: Alteration of acinar epithelium of, for example, mammary tissue to resemble apocrine glands.
created by: George Gkoutos
has_obo_namespace: mouse_pathology.ontology
id: MPATH:163

Axiom
annotated source: apocrine metaplasia
annotated property: definition
annotated target: Alteration of acinar epithelium of, for example, mammary tissue to resemble apocrine glands.
database_cross_reference: ISBN:0781727286

gastric metaplasia
type: Class
subclass of: epithelial metaplasia
definition: Appearance of heterotopic gastric epithelium.
created by: George Gkoutos
has_obo_namespace: mouse_pathology.ontology
id: MPATH:164

Axiom
annotated source: gastric metaplasia
annotated property: definition
annotated target: Appearance of heterotopic gastric epithelium.
database_cross_reference: ISBN:0781727286

glandular metaplasia
type: Class
subclass of: epithelial metaplasia
definition: Development of heterotopic glandular epithelia.
created by: George Gkoutos
has_obo_namespace: mouse_pathology.ontology
id: MPATH:165

Axiom
annotated source: glandular metaplasia
annotated property: definition
annotated target: Development of heterotopic glandular epithelia.
database_cross_reference: ISBN:0781727286

goblet cell metaplasia
type: Class
subclass of: epithelial metaplasia
definition: Metaplasia resulting in formation of mucus secreting goblet cells.
created by: George Gkoutos
has_obo_namespace: mouse_pathology.ontology
id: MPATH:166

Axiom
annotated source: goblet cell metaplasia
annotated property: definition
annotated target: Metaplasia resulting in formation of mucus secreting goblet cells.
database_cross_reference: ISBN:0781727286

intestinal metaplasia
type: Class
subclass of: epithelial metaplasia
definition: Appearance of heterotopic intestinal epithelium.
created by: George Gkoutos
has_obo_namespace: mouse_pathology.ontology
id: MPATH:167

Axiom
annotated source: intestinal metaplasia
annotated property: definition
annotated target: Appearance of heterotopic intestinal epithelium.
database_cross_reference: ISBN:0781727286

lipomatous metaplasia
type: Class
subclass of: metaplastic tissue
definition: Metaplasia resulting in formation of fat cells.
created by: George Gkoutos
has_obo_namespace: mouse_pathology.ontology
id: MPATH:168

Axiom
annotated source: lipomatous metaplasia
annotated property: definition
annotated target: Metaplasia resulting in formation of fat cells.
database_cross_reference: ISBN:0781727286

nephrogenic metaplasia
type: Class
subclass of: epithelial metaplasia
definition: .A rare benign neoplasm of the mucosa of the urinary bladder or the urethra, consisting of tubular structures resembling those of the nephron.
created by: George Gkoutos
has_obo_namespace: mouse_pathology.ontology
has_related_synonym: nephrogenic adenoma
id: MPATH:169

Axiom
annotated source: nephrogenic metaplasia
annotated property: definition
annotated target: .A rare benign neoplasm of the mucosa of the urinary bladder or the urethra, consisting of tubular structures resembling those of the nephron.
database_cross_reference: ISBN:0781727286

Axiom
annotated source: nephrogenic metaplasia
annotated property: has_related_synonym
annotated target: nephrogenic adenoma
database_cross_reference: Pathbase: Curation

subcellular defect
type: Class
subclass of: cell and tissue damage
definition: Defect of a subcellular structure or organelle.
created by: George Gkoutos
has_obo_namespace: mouse_pathology.ontology
id: MPATH:17

Axiom
annotated source: subcellular defect
annotated property: definition
annotated target: Defect of a subcellular structure or organelle.
database_cross_reference: Pathbase: Pathology Committee

oncocytic metaplasia
type: Class
subclass of: epithelial metaplasia
definition: Appearance of oncocytic cells in for example an epithelium or tumor.
created by: George Gkoutos
has_obo_namespace: mouse_pathology.ontology
id: MPATH:170
comment: An oncocyte is an acidophilic cell containing numerous mitochondria - an oxophil cell.

Axiom
annotated source: oncocytic metaplasia
annotated property: definition
annotated target: Appearance of oncocytic cells in for example an epithelium or tumor.
database_cross_reference: ISBN:0781727286

squamous metaplasia
type: Class
subclass of: epithelial metaplasia
definition: Change of a glandular or mucosal epithelium into squamous epithelium.
created by: George Gkoutos
has_obo_namespace: mouse_pathology.ontology
id: MPATH:171

Axiom
annotated source: squamous metaplasia
annotated property: definition
annotated target: Change of a glandular or mucosal epithelium into squamous epithelium.
database_cross_reference: ISBN:0781727286

transitional cell metaplasia
type: Class
subclass of: epithelial metaplasia
definition: Metaplastic response of the transitional epithelium, for example in the bladder to give squamous metaplasia and glandular metaplasia for example.
created by: George Gkoutos
has_obo_namespace: mouse_pathology.ontology
id: MPATH:172

Axiom
annotated source: transitional cell metaplasia
annotated property: definition
annotated target: Metaplastic response of the transitional epithelium, for example in the bladder to give squamous metaplasia and glandular metaplasia for example.
database_cross_reference: ISBN:0781727286

myeloid metaplasia
type: Class
subclass of: myeloproliferative disease
definition: A progressive disease of the bone marrow where neoplastic bone marrow stem cells lodge and grow at sites outside the bone marrow.
created by: George Gkoutos
has_obo_namespace: mouse_pathology.ontology
id: MPATH:173

Axiom
annotated source: myeloid metaplasia
annotated property: definition
annotated target: A progressive disease of the bone marrow where neoplastic bone marrow stem cells lodge and grow at sites outside the bone marrow.
database_cross_reference: ISBN:0781727286

osseous metaplasia
type: Class
subclass of: metaplastic tissue
definition: Metaplasia resulting in formation of bone.
created by: George Gkoutos
has_broad_synonym: ectopic bone
has_obo_namespace: mouse_pathology.ontology
id: MPATH:174

Axiom
annotated source: osseous metaplasia
annotated property: definition
annotated target: Metaplasia resulting in formation of bone.
database_cross_reference: ISBN:0781727286

healing and repair process
type: Class
subclass of: pathological process
definition: The process, normal or abnormal, of damage repair or wound closure.
created by: George Gkoutos
has_obo_namespace: mouse_pathology.ontology
id: MPATH:175

Axiom
annotated source: healing and repair process
annotated property: definition
annotated target: The process, normal or abnormal, of damage repair or wound closure.
database_cross_reference: Pathbase: Pathology Committee

connective tissue replacement
type: Class
subclass of: healing and repair process
definition: Replacement of connective tissue by fibro-fatty deposits and scar tissue.
created by: George Gkoutos
has_obo_namespace: mouse_pathology.ontology
id: MPATH:176

Axiom
annotated source: connective tissue replacement
annotated property: definition
annotated target: Replacement of connective tissue by fibro-fatty deposits and scar tissue.
database_cross_reference: Pathbase: Curation

angiogenesis
type: Class
subclass of: connective tissue replacement
definition: Aberrant process of blood vessel formation and the subsequent remodeling process; does not refer to the initial establishment of the vascular network by vasculogenesis.
created by: George Gkoutos
has_obo_namespace: mouse_pathology.ontology
has_related_synonym: neovascularisation
id: MPATH:177

Axiom
annotated source: angiogenesis
annotated property: definition
annotated target: Aberrant process of blood vessel formation and the subsequent remodeling process; does not refer to the initial establishment of the vascular network by vasculogenesis.
database_cross_reference: Pathbase: Curation

extracellular matrix deposition
type: Class
subclass of: connective tissue replacement
definition: Abnormal deposition of extracellular matrix proteins or other components.
created by: George Gkoutos
has_obo_namespace: mouse_pathology.ontology
id: MPATH:178

Axiom
annotated source: extracellular matrix deposition
annotated property: definition
annotated target: Abnormal deposition of extracellular matrix proteins or other components.
database_cross_reference: Pathbase: Curation

fibrin deposition
type: Class
subclass of: connective tissue replacement
definition: Deposition of fibrin.
created by: George Gkoutos
has_obo_namespace: mouse_pathology.ontology
id: MPATH:179

Axiom
annotated source: fibrin deposition
annotated property: definition
annotated target: Deposition of fibrin.
database_cross_reference: Pathbase: Curation

cytoskeletal defect
type: Class
subclass of: subcellular defect
definition: Defect in the structure or function of the cytoskeleton.
created by: George Gkoutos
has_obo_namespace: mouse_pathology.ontology
id: MPATH:18

Axiom
annotated source: cytoskeletal defect
annotated property: definition
annotated target: Defect in the structure or function of the cytoskeleton.
database_cross_reference: Pathbase: Pathology Committee

fibroblast proliferation
type: Class
subclass of: connective tissue replacement
definition: Abnormal or reactive proliferation of fibroblasts.
created by: George Gkoutos
has_obo_namespace: mouse_pathology.ontology
id: MPATH:180

Axiom
annotated source: fibroblast proliferation
annotated property: definition
annotated target: Abnormal or reactive proliferation of fibroblasts.
database_cross_reference: Pathbase: Curation

fibrosis
type: Class
subclass of: connective tissue replacement
definition: Reactive formation of fibrous tissue.
created by: George Gkoutos
has_obo_namespace: mouse_pathology.ontology
id: MPATH:181

Axiom
annotated source: fibrosis
annotated property: definition
annotated target: Reactive formation of fibrous tissue.
database_cross_reference: Pathbase: Curation

gliosis
type: Class
subclass of: connective tissue replacement
definition: Proliferation of astrocytes in an area of damage in the brain or spinal cord.
created by: George Gkoutos
has_obo_namespace: mouse_pathology.ontology
id: MPATH:182

Axiom
annotated source: gliosis
annotated property: definition
annotated target: Proliferation of astrocytes in an area of damage in the brain or spinal cord.
database_cross_reference: Pathbase: Curation

granulation tissue
type: Class
subclass of: healing and repair structure
definition: Newly formed connective (vascular or fibrous)tissue caused by inflammation or healing (repair) processes. Microscopically consists of capillaries fibroblastic cells and inflammatory cells.
created by: George Gkoutos
has_obo_namespace: mouse_pathology.ontology
id: MPATH:183

Axiom
annotated source: granulation tissue
annotated property: definition
annotated target: Newly formed connective (vascular or fibrous)tissue caused by inflammation or healing (repair) processes. Microscopically consists of capillaries fibroblastic cells and inflammatory cells.
database_cross_reference: Pathbase: Pathology Committee

sclerosis
type: Class
subclass of: connective tissue replacement
definition: Any pathological thickening or hardening of a tissue.
created by: George Gkoutos
has_obo_namespace: mouse_pathology.ontology
has_related_synonym: Induration
id: MPATH:184

Axiom
annotated source: sclerosis
annotated property: definition
annotated target: Any pathological thickening or hardening of a tissue.
database_cross_reference: Pathbase: Curation

Axiom
annotated source: sclerosis
annotated property: has_related_synonym
annotated target: Induration
database_cross_reference: Pathbase: Curation

parenchymal regeneration
type: Class
subclass of: healing and repair process
definition: Post-injury regeneration of the functional tissue parenchyma. Eg. Liver.
created by: George Gkoutos
has_obo_namespace: mouse_pathology.ontology
id: MPATH:185

Axiom
annotated source: parenchymal regeneration
annotated property: definition
annotated target: Post-injury regeneration of the functional tissue parenchyma. Eg. Liver.
database_cross_reference: Pathbase: Curation

complete parenchymal regeneration
type: Class
subclass of: parenchymal regeneration
definition: Complete healing through parenchymal regeneration - no fibrosis.
created by: George Gkoutos
has_obo_namespace: mouse_pathology.ontology
id: MPATH:186

Axiom
annotated source: complete parenchymal regeneration
annotated property: definition
annotated target: Complete healing through parenchymal regeneration - no fibrosis.
database_cross_reference: Pathbase: Curation

incomplete parenchymal regeneration
type: Class
subclass of: parenchymal regeneration
definition: Incomplete healing usually accompanied by fibrosis.
created by: George Gkoutos
has_obo_namespace: mouse_pathology.ontology
id: MPATH:187

Axiom
annotated source: incomplete parenchymal regeneration
annotated property: definition
annotated target: Incomplete healing usually accompanied by fibrosis.
database_cross_reference: Pathbase: Pathology Committee

immunopathological process
type: Class
subclass of: pathological process
definition: Inappropriate or aberrant activation or suppression of the immune or inflammatory response.
created by: George Gkoutos
has_obo_namespace: mouse_pathology.ontology
id: MPATH:188

Axiom
annotated source: immunopathological process
annotated property: definition
annotated target: Inappropriate or aberrant activation or suppression of the immune or inflammatory response.
database_cross_reference: Pathbase: Pathology Committee

hypersensitivity disease
type: Class
subclass of: immunopathological process
definition: Immune response resulting in tissue injury.
created by: George Gkoutos
has_obo_namespace: mouse_pathology.ontology
id: MPATH:189

Axiom
annotated source: hypersensitivity disease
annotated property: definition
annotated target: Immune response resulting in tissue injury.
database_cross_reference: Pathbase: Curation

endoplasmic reticulum defect
type: Class
subclass of: subcellular defect
definition: Defect in the structure or function of the endoplasmic reticulum.
created by: George Gkoutos
has_obo_namespace: mouse_pathology.ontology
id: MPATH:19

Axiom
annotated source: endoplasmic reticulum defect
annotated property: definition
annotated target: Defect in the structure or function of the endoplasmic reticulum.
database_cross_reference: Pathbase: Pathology Committee

type I hypersensitivity
type: Class
subclass of: hypersensitivity disease
definition: This is manifested by localized or generalized reaction that occurs immediately (minutes) after exposure to an antigen to which the person/animal was previously sensitized. It is IgE-mediated, and mast cell activation and degranulation are hallmarks.
created by: George Gkoutos
has_obo_namespace: mouse_pathology.ontology
id: MPATH:190

Axiom
annotated source: type I hypersensitivity
annotated property: definition
annotated target: This is manifested by localized or generalized reaction that occurs immediately (minutes) after exposure to an antigen to which the person/animal was previously sensitized. It is IgE-mediated, and mast cell activation and degranulation are hallmarks.
database_cross_reference: ISBN:0781727286

type II hypersensitivity
type: Class
subclass of: hypersensitivity disease
definition: Caused by an antibody/antigen reaction: antibodies are directly or indirectly cytotoxic to antigens on cell surfaces or in connective tissues.
created by: George Gkoutos
has_obo_namespace: mouse_pathology.ontology
id: MPATH:191
comment: Most often involves IgG and IgM. Complement activation is usually involved.

Axiom
annotated source: type II hypersensitivity
annotated property: definition
annotated target: Caused by an antibody/antigen reaction: antibodies are directly or indirectly cytotoxic to antigens on cell surfaces or in connective tissues.
database_cross_reference: ISBN:0781727286

type III hypersensitivity
type: Class
subclass of: hypersensitivity disease
definition: Tissue injury mediated by immune complexes. Generally involves immune complexes formed in the blood via antibodies encountering circulating antigens. Immune complexes then deposit in tissues (especially blood vessels and glomeruli), induce complement activation, and result in tissue injury.
created by: George Gkoutos
has_obo_namespace: mouse_pathology.ontology
id: MPATH:192

Axiom
annotated source: type III hypersensitivity
annotated property: definition
annotated target: Tissue injury mediated by immune complexes. Generally involves immune complexes formed in the blood via antibodies encountering circulating antigens. Immune complexes then deposit in tissues (especially blood vessels and glomeruli), induce complement activation, and result in tissue injury.
database_cross_reference: ISBN:0781727286

type IV hypersensitivity
type: Class
subclass of: hypersensitivity disease
definition: An antigen-elicited cellular immune reaction that results in tissue damage, but does not require Ab participation. The response is seen at the area of contact.
created by: George Gkoutos
has_obo_namespace: mouse_pathology.ontology
id: MPATH:193

Axiom
annotated source: type IV hypersensitivity
annotated property: definition
annotated target: An antigen-elicited cellular immune reaction that results in tissue damage, but does not require Ab participation. The response is seen at the area of contact.
database_cross_reference: ISBN:0781727286

immune mediated disease
type: Class
subclass of: immunopathological process
definition: Tissue response to inappropriate immune/inflammatory process.
created by: George Gkoutos
has_obo_namespace: mouse_pathology.ontology
id: MPATH:194

Axiom
annotated source: immune mediated disease
annotated property: definition
annotated target: Tissue response to inappropriate immune/inflammatory process.
database_cross_reference: Pathbase: Curation

arthritis
type: Class
subclass of: inflammation
definition: Inflammation of a joint.
created by: George Gkoutos
has_obo_namespace: mouse_pathology.ontology
id: MPATH:195

Axiom
annotated source: arthritis
annotated property: definition
annotated target: Inflammation of a joint.
database_cross_reference: Pathbase: Curation

dermatitis
type: Class
subclass of: inflammation
definition: Inflammation of the skin.
created by: George Gkoutos
has_obo_namespace: mouse_pathology.ontology
id: MPATH:196

Axiom
annotated source: dermatitis
annotated property: definition
annotated target: Inflammation of the skin.
database_cross_reference: Pathbase: Curation

glomerulonephritis
type: Class
subclass of: inflammation
definition: Renal disease characterised by diffuse inflammatory changes in glomeruli not in response to an infectious agent or treatment.
created by: George Gkoutos
has_obo_namespace: mouse_pathology.ontology
id: MPATH:197

Axiom
annotated source: glomerulonephritis
annotated property: definition
annotated target: Renal disease characterised by diffuse inflammatory changes in glomeruli not in response to an infectious agent or treatment.
database_cross_reference: Pathbase: Curation

immune mediated hemolytic anaemia
type: Class
subclass of: inflammation
definition: An anemic/erythrocytopenic condition resulting from an increased rate of immune mediated erythrocyte destruction.
created by: George Gkoutos
has_obo_namespace: mouse_pathology.ontology
id: MPATH:198

Axiom
annotated source: immune mediated hemolytic anaemia
annotated property: definition
annotated target: An anemic/erythrocytopenic condition resulting from an increased rate of immune mediated erythrocyte destruction.
database_cross_reference: ISBN:0781727286

immune mediated thrombocytopenia
type: Class
subclass of: inflammation
definition: A condition resulting from an increased rate of immune mediated platelet destruction.
created by: George Gkoutos
has_obo_namespace: mouse_pathology.ontology
id: MPATH:199

Axiom
annotated source: immune mediated thrombocytopenia
annotated property: definition
annotated target: A condition resulting from an increased rate of immune mediated platelet destruction.
database_cross_reference: ISBN:0781727286

cell death
type: Class
subclass of: cell and tissue damage process
definition: Complete and irreversible cessation of metabolic activity.
created by: George Gkoutos
has_obo_namespace: mouse_pathology.ontology
id: MPATH:2

Axiom
annotated source: cell death
annotated property: definition
annotated target: Complete and irreversible cessation of metabolic activity.
database_cross_reference: Pathbase: Pathology Committee

golgi defect
type: Class
subclass of: subcellular defect
definition: Defect in the structure or function of the golgi apparatus.
created by: George Gkoutos
has_obo_namespace: mouse_pathology.ontology
id: MPATH:20

Axiom
annotated source: golgi defect
annotated property: definition
annotated target: Defect in the structure or function of the golgi apparatus.
database_cross_reference: Pathbase: Pathology Committee

myositis
type: Class
subclass of: inflammation
definition: Inflammation of a muscle.
created by: George Gkoutos
has_obo_namespace: mouse_pathology.ontology
has_related_synonym: Initis
id: MPATH:200

Axiom
annotated source: myositis
annotated property: definition
annotated target: Inflammation of a muscle.
database_cross_reference: Pathbase: Curation

Axiom
annotated source: myositis
annotated property: has_related_synonym
annotated target: Initis
database_cross_reference: Pathbase: Curation

vasculitis
type: Class
subclass of: inflammation
definition: Inflammation of a blood vessel.
created by: George Gkoutos
has_obo_namespace: mouse_pathology.ontology
has_related_synonym: angiitis
has_related_synonym: arteritis
has_related_synonym: lymphangiitis
has_related_synonym: phlebitis
id: MPATH:201

Axiom
annotated source: vasculitis
annotated property: definition
annotated target: Inflammation of a blood vessel.
database_cross_reference: Pathbase: Pathology Committee

Axiom
annotated source: vasculitis
annotated property: has_related_synonym
annotated target: angiitis
database_cross_reference: Pathbase: Curation

Axiom
annotated source: vasculitis
annotated property: has_related_synonym
annotated target: arteritis
database_cross_reference: Pathbase: Curation

Axiom
annotated source: vasculitis
annotated property: has_related_synonym
annotated target: lymphangiitis
database_cross_reference: Pathbase: Curation

Axiom
annotated source: vasculitis
annotated property: has_related_synonym
annotated target: phlebitis
database_cross_reference: Pathbase: Curation

immunodeficiency disease
type: Class
subclass of: immunopathological process
definition: Defective immune response; can be primary due to defect in immune system or secondary/acquired due to disease.
created by: George Gkoutos
has_obo_namespace: mouse_pathology.ontology
id: MPATH:202

Axiom
annotated source: immunodeficiency disease
annotated property: definition
annotated target: Defective immune response; can be primary due to defect in immune system or secondary/acquired due to disease.
database_cross_reference: Pathbase: Curation

general immunodeficiency disease
type: Class
definition: general immunodeficiency disease
has_obo_namespace: mouse_pathology.ontology
id: MPATH:203
comment: obsolete. Subsumed into MPATH:202
deprecated: true

Axiom
annotated source: general immunodeficiency disease
annotated property: definition
annotated target: general immunodeficiency disease
database_cross_reference: Pathbase: Curation

chronic/recurrent inflammatory disease
type: Class
definition: chronic/recurrent inflammatory disease
has_obo_namespace: mouse_pathology.ontology
id: MPATH:204
comment: obsolete. Subsumed into MPATH: 214.
deprecated: true

Axiom
annotated source: chronic/recurrent inflammatory disease
annotated property: definition
annotated target: chronic/recurrent inflammatory disease
database_cross_reference: Pathbase: Curation

immunodeficiency associated infection
type: Class
definition: Infection with bacteria, viruses or fungi subsequent to immunodeficiency.
has_obo_namespace: mouse_pathology.ontology
id: MPATH:205
deprecated: true

Axiom
annotated source: immunodeficiency associated infection
annotated property: definition
annotated target: Infection with bacteria, viruses or fungi subsequent to immunodeficiency.
database_cross_reference: Pathbase: Pathology Committee

primary immunodeficiency disease
type: Class
subclass of: immunodeficiency disease
definition: Disease due to primary molecular or cellular defect in the immune system or its development.
created by: George Gkoutos
has_obo_namespace: mouse_pathology.ontology
id: MPATH:206

Axiom
annotated source: primary immunodeficiency disease
annotated property: definition
annotated target: Disease due to primary molecular or cellular defect in the immune system or its development.
database_cross_reference: Pathbase: Curation

immunodeficiency - lymphoid defect
type: Class
subclass of: primary immunodeficiency disease
definition: Primary defect in the lymphoid arm of the immune system.
created by: George Gkoutos
has_obo_namespace: mouse_pathology.ontology
id: MPATH:207

Axiom
annotated source: immunodeficiency - lymphoid defect
annotated property: definition
annotated target: Primary defect in the lymphoid arm of the immune system.
database_cross_reference: Pathbase: Curation

immunodeficiency - myeloid/phagocytic defect
type: Class
subclass of: primary immunodeficiency disease
definition: Primary defect in the myeloid arm of the immune system.
created by: George Gkoutos
has_obo_namespace: mouse_pathology.ontology
id: MPATH:208

Axiom
annotated source: immunodeficiency - myeloid/phagocytic defect
annotated property: definition
annotated target: Primary defect in the myeloid arm of the immune system.
database_cross_reference: Pathbase: Curation

secondary immunodeficiency disease
type: Class
subclass of: immunodeficiency disease
definition: Defect in the immune system subsequent to external injury, infection, ablation or deficiency.
created by: George Gkoutos
has_obo_namespace: mouse_pathology.ontology
id: MPATH:209

Axiom
annotated source: secondary immunodeficiency disease
annotated property: definition
annotated target: Defect in the immune system subsequent to external injury, infection, ablation or deficiency.
database_cross_reference: Pathbase: Curation

lysosomal defect
type: Class
subclass of: subcellular defect
definition: Defect in the structure or function of the lysosomes.
created by: George Gkoutos
has_obo_namespace: mouse_pathology.ontology
id: MPATH:21

Axiom
annotated source: lysosomal defect
annotated property: definition
annotated target: Defect in the structure or function of the lysosomes.
database_cross_reference: Pathbase: Curation

acquired immunodeficiency
type: Class
subclass of: secondary immunodeficiency disease
definition: Defect in the immune system subsequent to external injury, infection or ablation.
created by: George Gkoutos
has_obo_namespace: mouse_pathology.ontology
id: MPATH:210

Axiom
annotated source: acquired immunodeficiency
annotated property: definition
annotated target: Defect in the immune system subsequent to external injury, infection or ablation.
database_cross_reference: Pathbase: Curation

failed transfer of maternal immunoglobulin
type: Class
subclass of: secondary immunodeficiency disease
definition: Defect in the immune system subsequent to failure to attain passive immunity from maternal transfer of immunoglobulins.
created by: George Gkoutos
has_obo_namespace: mouse_pathology.ontology
id: MPATH:211

Axiom
annotated source: failed transfer of maternal immunoglobulin
annotated property: definition
annotated target: Defect in the immune system subsequent to failure to attain passive immunity from maternal transfer of immunoglobulins.
database_cross_reference: Pathbase: Pathology Committee

inflammation
type: Class
subclass of: immune mediated disease
definition: A tissue reaction to an internal or external injury.
created by: George Gkoutos
has_obo_namespace: mouse_pathology.ontology
id: MPATH:212

Axiom
annotated source: inflammation
annotated property: definition
annotated target: A tissue reaction to an internal or external injury.
database_cross_reference: Pathbase: Pathology Committee

acute inflammation
type: Class
subclass of: inflammation
definition: Inflammation with a recent onset, characterised histologically by primarily granulocyte infiltration, edema and hyperemia.
created by: George Gkoutos
has_obo_namespace: mouse_pathology.ontology
id: MPATH:213
comment: The five classical signs of inflammation: Rubor, tumor, calor, dolor, functio laesa (Galen 300BC).

Axiom
annotated source: acute inflammation
annotated property: definition
annotated target: Inflammation with a recent onset, characterised histologically by primarily granulocyte infiltration, edema and hyperemia.
database_cross_reference: Pathbase: Pathology Committee

chronic inflammation
type: Class
subclass of: inflammation
definition: Chronic inflammatory condition characterised by infiltration of primarily lymphocytes.
created by: George Gkoutos
has_obo_namespace: mouse_pathology.ontology
id: MPATH:214

Axiom
annotated source: chronic inflammation
annotated property: definition
annotated target: Chronic inflammatory condition characterised by infiltration of primarily lymphocytes.
database_cross_reference: Pathbase: Pathology Committee

granulomatous inflammation
type: Class
subclass of: inflammation
definition: Nodular inflammatory reaction, containing compactly grouped epithelioid cells, giant cells, and other macrophages. The basic inflammatory unit is termed a granuloma.
created by: George Gkoutos
has_obo_namespace: mouse_pathology.ontology
id: MPATH:215

Axiom
annotated source: granulomatous inflammation
annotated property: definition
annotated target: Nodular inflammatory reaction, containing compactly grouped epithelioid cells, giant cells, and other macrophages. The basic inflammatory unit is termed a granuloma.
database_cross_reference: ISBN:0781727286

necrotic inflammation
type: Class
subclass of: inflammation
definition: Acute inflammatory reaction in which the predominant histological change is rapid diffuse necrosis throughout the affected tissue.
created by: George Gkoutos
has_obo_namespace: mouse_pathology.ontology
id: MPATH:216

Axiom
annotated source: necrotic inflammation
annotated property: definition
annotated target: Acute inflammatory reaction in which the predominant histological change is rapid diffuse necrosis throughout the affected tissue.
database_cross_reference: ISBN:0781727286

ulcerative inflammation
type: Class
definition: Combination of inflammation, often suppurative or granulomatous, with ulceration.
has_obo_namespace: mouse_pathology.ontology
id: MPATH:217
comment: Ulcers may be a component or inflammation. Use MPATH: Ulcer
deprecated: true

Axiom
annotated source: ulcerative inflammation
annotated property: definition
annotated target: Combination of inflammation, often suppurative or granulomatous, with ulceration.
database_cross_reference: ISBN:0781727286

neoplasm
type: Class
subclass of: pathological anatomical entity
definition: A tumor resulting from abnormal and uncontrolled autonomous new cell growth (proliferation)that may be benign or malignant.
created by: George Gkoutos
has_obo_namespace: mouse_pathology.ontology
id: MPATH:218

Axiom
annotated source: neoplasm
annotated property: definition
annotated target: A tumor resulting from abnormal and uncontrolled autonomous new cell growth (proliferation)that may be benign or malignant.
database_cross_reference: Pathbase: Pathology Committee

adnexal and skin appendage tumor
type: Class
subclass of: neoplasm
definition: Tumors of the skin, its constituent structures and glands including the mammary gland, apocrine and eccrine glands, hair follicles and associated structures.
created by: George Gkoutos
has_obo_namespace: mouse_pathology.ontology
id: MPATH:219

Axiom
annotated source: adnexal and skin appendage tumor
annotated property: definition
annotated target: Tumors of the skin, its constituent structures and glands including the mammary gland, apocrine and eccrine glands, hair follicles and associated structures.
database_cross_reference: Pathbase: Curation

mitochondrial defect
type: Class
subclass of: subcellular defect
definition: Defect in the structure or function of the mitochondria.
created by: George Gkoutos
has_obo_namespace: mouse_pathology.ontology
id: MPATH:22

Axiom
annotated source: mitochondrial defect
annotated property: definition
annotated target: Defect in the structure or function of the mitochondria.
database_cross_reference: Pathbase: Curation

apocrine adenocarcinoma
type: Class
subclass of: adnexal and skin appendage tumor
subclass of: adenocarcinoma
definition: Carcinoma of the glandular epithelium of apocrine glands (M-8401/3).
created by: George Gkoutos
has_obo_namespace: mouse_pathology.ontology
id: MPATH:220

Axiom
annotated source: apocrine adenocarcinoma
annotated property: definition
annotated target: Carcinoma of the glandular epithelium of apocrine glands (M-8401/3).
database_cross_reference: Pathbase: Pathology Committee

apocrine adenoma
type: Class
subclass of: adnexal and skin appendage tumor
subclass of: adenoma
definition: Benign neoplasm of the epithelium of apocrine glands (M-8401/0).
created by: George Gkoutos
has_obo_namespace: mouse_pathology.ontology
id: MPATH:221

Axiom
annotated source: apocrine adenoma
annotated property: definition
annotated target: Benign neoplasm of the epithelium of apocrine glands (M-8401/0).
database_cross_reference: Pathbase: Curation

ceruminous adenocarcinoma
type: Class
subclass of: adnexal and skin appendage tumor
subclass of: adenocarcinoma
definition: Malignant carcinoma of the ceruminous gland (M-8420/3).
created by: George Gkoutos
has_obo_namespace: mouse_pathology.ontology
id: MPATH:222

Axiom
annotated source: ceruminous adenocarcinoma
annotated property: definition
annotated target: Malignant carcinoma of the ceruminous gland (M-8420/3).
database_cross_reference: Pathbase: Curation

ceruminous adenoma
type: Class
subclass of: adnexal and skin appendage tumor
subclass of: adenoma
definition: Benign adenomatous neoplasia of the ceruminous glands of the external auditory meatus (M-8420/0).
has_obo_namespace: mouse_pathology.ontology
id: MPATH:223

Axiom
annotated source: ceruminous adenoma
annotated property: definition
annotated target: Benign adenomatous neoplasia of the ceruminous glands of the external auditory meatus (M-8420/0).
database_cross_reference: Pathbase: Curation

clear cell hidradenoma
type: Class
subclass of: adnexal and skin appendage tumor
subclass of: adenoma
definition: Tumor derived from eccrine sweat glands composed of clear glycogen rich cells. ( M-84020 ).
has_obo_namespace: mouse_pathology.ontology
has_related_synonym: Eccrine acrospiroma
has_related_synonym: nodular hidradenoma
id: MPATH:224

Axiom
annotated source: clear cell hidradenoma
annotated property: definition
annotated target: Tumor derived from eccrine sweat glands composed of clear glycogen rich cells. ( M-84020 ).
database_cross_reference: Pathbase: Curation

Axiom
annotated source: clear cell hidradenoma
annotated property: has_related_synonym
annotated target: Eccrine acrospiroma
database_cross_reference: Pathbase: Curation

Axiom
annotated source: clear cell hidradenoma
annotated property: has_related_synonym
annotated target: nodular hidradenoma
database_cross_reference: Pathbase: Curation

eccrine gland adenocarcinoma
type: Class
subclass of: adnexal and skin appendage tumor
subclass of: adenocarcinoma
definition: Malignant neoplasm of the eccrine gland (M-8413/3).
has_obo_namespace: mouse_pathology.ontology
id: MPATH:225

Axiom
annotated source: eccrine gland adenocarcinoma
annotated property: definition
annotated target: Malignant neoplasm of the eccrine gland (M-8413/3).
database_cross_reference: Pathbase: Curation

eccrine gland adenoma
type: Class
subclass of: adnexal and skin appendage tumor
subclass of: adenoma
definition: Benign neoplasm of the eccrine gland (M-8408/0).
has_obo_namespace: mouse_pathology.ontology
id: MPATH:226

Axiom
annotated source: eccrine gland adenoma
annotated property: definition
annotated target: Benign neoplasm of the eccrine gland (M-8408/0).
database_cross_reference: :Papillary adenoma

eccrine papillary adenoma
type: Class
subclass of: adnexal and skin appendage tumor
subclass of: adenoma
definition: Papillary form of eccrine sweat gland adenoma. (M -8408/0).
has_obo_namespace: mouse_pathology.ontology
has_related_synonym: Papillary adenoma
has_related_synonym: benign neoplasm of the eccrine gland, papillary form
id: MPATH:227

Axiom
annotated source: eccrine papillary adenoma
annotated property: definition
annotated target: Papillary form of eccrine sweat gland adenoma. (M -8408/0).
database_cross_reference: Pathbase: Pathology Committee

Axiom
annotated source: eccrine papillary adenoma
annotated property: has_related_synonym
annotated target: Papillary adenoma
database_cross_reference: Pathbase: Curation

Axiom
annotated source: eccrine papillary adenoma
annotated property: has_related_synonym
annotated target: benign neoplasm of the eccrine gland, papillary form
database_cross_reference: Pathbase: Curation

papillary hidradenoma
type: Class
subclass of: adnexal and skin appendage tumor
subclass of: adenoma
definition: Benign apocrine sweat gland tumor (8405/0).
has_obo_namespace: mouse_pathology.ontology
has_related_synonym: Hidradenoma papilliferum
id: MPATH:228

Axiom
annotated source: papillary hidradenoma
annotated property: definition
annotated target: Benign apocrine sweat gland tumor (8405/0).
database_cross_reference: Pathbase: Curation

Axiom
annotated source: papillary hidradenoma
annotated property: has_related_synonym
annotated target: Hidradenoma papilliferum
database_cross_reference: Pathbase: Curation

sebaceous adenocarcinoma
type: Class
subclass of: adnexal and skin appendage tumor
subclass of: adenocarcinoma
definition: Malignant neoplasm of the sebaceous cells - rare areas of differentiation, severe nuclear atypia (M-8410/3).
has_obo_namespace: mouse_pathology.ontology
has_related_synonym: sebaceous carcinoma
id: MPATH:229

Axiom
annotated source: sebaceous adenocarcinoma
annotated property: definition
annotated target: Malignant neoplasm of the sebaceous cells - rare areas of differentiation, severe nuclear atypia (M-8410/3).
database_cross_reference: Pathbase: Curation

Axiom
annotated source: sebaceous adenocarcinoma
annotated property: has_related_synonym
annotated target: sebaceous carcinoma
database_cross_reference: Pathbase: Curation

peroxysomal defect
type: Class
subclass of: subcellular defect
definition: Defect in the structure or function of the peroxysomes.
has_obo_namespace: mouse_pathology.ontology
id: MPATH:23

Axiom
annotated source: peroxysomal defect
annotated property: definition
annotated target: Defect in the structure or function of the peroxysomes.
database_cross_reference: Pathbase: Curation

sebaceous adenoma
type: Class
subclass of: adnexal and skin appendage tumor
subclass of: adenoma
definition: Adenoma of sebaceous cells; regular architecture of gland not mantained. Large numbers of immature germinative cells present. Mitoses. (M-8410/0).
has_obo_namespace: mouse_pathology.ontology
has_related_synonym: Epithelioma
id: MPATH:230

Axiom
annotated source: sebaceous adenoma
annotated property: definition
annotated target: Adenoma of sebaceous cells; regular architecture of gland not mantained. Large numbers of immature germinative cells present. Mitoses. (M-8410/0).
database_cross_reference: Pathbase: Curation

Axiom
annotated source: sebaceous adenoma
annotated property: has_related_synonym
annotated target: Epithelioma
database_cross_reference: Pathbase: Curation

syringoma
type: Class
subclass of: adnexal and skin appendage tumor
definition: A benign, often multiple, sometimes eruptive neoplasm of the sweat gland ducts composed of very small round cysts. (M-8407/0).
has_obo_namespace: mouse_pathology.ontology
id: MPATH:231

Axiom
annotated source: syringoma
annotated property: definition
annotated target: A benign, often multiple, sometimes eruptive neoplasm of the sweat gland ducts composed of very small round cysts. (M-8407/0).
database_cross_reference: Pathbase: Curation

trichoepithelioma
type: Class
subclass of: basaloid follicular neoplasms
definition: Multiple small benign nodules derived from basal cells of hair follicles enclosing small cornified cell containing cysts. (M-8100/0).
has_obo_namespace: mouse_pathology.ontology
has_related_synonym: Epithelioma adenoides cysticum
has_related_synonym: benign
has_related_synonym: hair follicle tumor
id: MPATH:232

Axiom
annotated source: trichoepithelioma
annotated property: definition
annotated target: Multiple small benign nodules derived from basal cells of hair follicles enclosing small cornified cell containing cysts. (M-8100/0).
database_cross_reference: URL:http://emice.nci.nih.gov/emice/mouse_models/organ_models/skin_models

Axiom
annotated source: trichoepithelioma
annotated property: has_related_synonym
annotated target: Epithelioma adenoides cysticum
database_cross_reference: Pathbase: Curation

Axiom
annotated source: trichoepithelioma
annotated property: has_related_synonym
annotated target: benign
database_cross_reference: Pathbase: Curation

Axiom
annotated source: trichoepithelioma
annotated property: has_related_synonym
annotated target: hair follicle tumor
database_cross_reference: Pathbase: Curation

basal cell tumor
type: Class
subclass of: adnexal and skin appendage tumor
subclass of: adenoma
definition: Well circumscribed tumor of the basal cells of the epidermis. Rare mitotic figures, benign. (M8147/0).
has_obo_namespace: mouse_pathology.ontology
has_related_synonym: Benign basal cell tumor
has_related_synonym: basal cell adenoma
id: MPATH:233

Axiom
annotated source: basal cell tumor
annotated property: definition
annotated target: Well circumscribed tumor of the basal cells of the epidermis. Rare mitotic figures, benign. (M8147/0).
database_cross_reference: Pathbase: Pathology Committee

Axiom
annotated source: basal cell tumor
annotated property: has_related_synonym
annotated target: Benign basal cell tumor
database_cross_reference: Pathbase: Curation

Axiom
annotated source: basal cell tumor
annotated property: has_related_synonym
annotated target: basal cell adenoma
database_cross_reference: Pathbase: Curation

basal cell carcinoma
type: Class
subclass of: carcinoma
subclass of: basaloid follicular neoplasms
definition: Malignant neoplasm of the basal cells of the epidermis with local invasion. (M-8090/3).
has_obo_namespace: mouse_pathology.ontology
id: MPATH:234

Axiom
annotated source: basal cell carcinoma
annotated property: definition
annotated target: Malignant neoplasm of the basal cells of the epidermis with local invasion. (M-8090/3).
database_cross_reference: URL:http://emice.nci.nih.gov/emice/mouse_models/organ_models/skin_models

blood vessel tumor
type: Class
subclass of: neoplasm
definition: Tumor of venous or arterial vessels or capillaries.
has_obo_namespace: mouse_pathology.ontology
id: MPATH:235

Axiom
annotated source: blood vessel tumor
annotated property: definition
annotated target: Tumor of venous or arterial vessels or capillaries.
database_cross_reference: Pathbase: Pathology Committee

angiofibroma
type: Class
subclass of: blood vessel tumor
definition: .A benign neoplasm of fibrous tissue in which there are multiple large and small dilated vascular channels ( M9160/0).
has_obo_namespace: mouse_pathology.ontology
has_related_synonym: Telangiectatic fibroma
id: MPATH:236

Axiom
annotated source: angiofibroma
annotated property: definition
annotated target: .A benign neoplasm of fibrous tissue in which there are multiple large and small dilated vascular channels ( M9160/0).
database_cross_reference: Pathbase: Curation

Axiom
annotated source: angiofibroma
annotated property: has_related_synonym
annotated target: Telangiectatic fibroma
database_cross_reference: Pathbase: Curation

angiokeratoma
type: Class
subclass of: blood vessel tumor
definition: An intradermal capillary telangiectasis with hyperkeratosis and acanthosis (M-9141/0).
has_obo_namespace: mouse_pathology.ontology
has_related_synonym: keratoangioma
has_related_synonym: telangiectasia verrucosa
has_related_synonym: telangiectatic wart
id: MPATH:237

Axiom
annotated source: angiokeratoma
annotated property: definition
annotated target: An intradermal capillary telangiectasis with hyperkeratosis and acanthosis (M-9141/0).
database_cross_reference: Pathbase: Curation

Axiom
annotated source: angiokeratoma
annotated property: has_related_synonym
annotated target: keratoangioma
database_cross_reference: Pathbase: Curation

Axiom
annotated source: angiokeratoma
annotated property: has_related_synonym
annotated target: telangiectasia verrucosa
database_cross_reference: Pathbase: Curation

Axiom
annotated source: angiokeratoma
annotated property: has_related_synonym
annotated target: telangiectatic wart
database_cross_reference: Pathbase: Curation

hemangioblastoma
type: Class
subclass of: blood vessel tumor
definition: A benign neoplasm frequently arising in the cerebellum composed of capillary vessel forming endothelial cells and stromal cells. (M-9161/1).
has_obo_namespace: mouse_pathology.ontology
has_related_synonym: Angioblastoma
id: MPATH:238

Axiom
annotated source: hemangioblastoma
annotated property: definition
annotated target: A benign neoplasm frequently arising in the cerebellum composed of capillary vessel forming endothelial cells and stromal cells. (M-9161/1).
database_cross_reference: Pathbase: Pathology Committee

Axiom
annotated source: hemangioblastoma
annotated property: has_related_synonym
annotated target: Angioblastoma
database_cross_reference: Pathbase: Curation

hemangioendothelioma
type: Class
definition: hemangioendothelioma
has_obo_namespace: mouse_pathology.ontology
id: MPATH:239
comment: obsolete Use Hemangioma MPATH: 240
deprecated: true

Axiom
annotated source: hemangioendothelioma
annotated property: definition
annotated target: hemangioendothelioma
database_cross_reference: Pathbase: Curation

plasma membrane defect
type: Class
subclass of: subcellular defect
definition: Defect in the structure or function of the plasma membrane.
has_obo_namespace: mouse_pathology.ontology
id: MPATH:24

Axiom
annotated source: plasma membrane defect
annotated property: definition
annotated target: Defect in the structure or function of the plasma membrane.
database_cross_reference: Pathbase: Curation

hemangioma
type: Class
subclass of: blood vessel tumor
definition: Neoplasm derived from endothelial cells. May be of capillary or cavernous type with large vascular channels. (M-9130/0 + M-9120/0 respectively).
has_obo_namespace: mouse_pathology.ontology
has_related_synonym: Angioendothelioma.
has_related_synonym: Hemangioendothelioma, benign
id: MPATH:240

Axiom
annotated source: hemangioma
annotated property: definition
annotated target: Neoplasm derived from endothelial cells. May be of capillary or cavernous type with large vascular channels. (M-9130/0 + M-9120/0 respectively).
database_cross_reference: PMID:8569146

Axiom
annotated source: hemangioma
annotated property: has_related_synonym
annotated target: Angioendothelioma.
database_cross_reference: Pathbase: Curation

Axiom
annotated source: hemangioma
annotated property: has_related_synonym
annotated target: Hemangioendothelioma, benign
database_cross_reference: Pathbase: Curation

hemangiopericytoma
type: Class
subclass of: blood vessel tumor
definition: A vascular, usually benign, neoplasm composed of round and spindle cells derived from the pericytes and surround endothelium-lined vessels. (M-9150/0/1/3).
has_obo_namespace: mouse_pathology.ontology
has_related_synonym: Pericytoma
id: MPATH:241

Axiom
annotated source: hemangiopericytoma
annotated property: definition
annotated target: A vascular, usually benign, neoplasm composed of round and spindle cells derived from the pericytes and surround endothelium-lined vessels. (M-9150/0/1/3).
database_cross_reference: Pathbase: Pathology Committee

Axiom
annotated source: hemangiopericytoma
annotated property: has_related_synonym
annotated target: Pericytoma
database_cross_reference: Pathbase: Curation

hemangiosarcoma
type: Class
subclass of: blood vessel tumor
subclass of: sarcoma
definition: Malignant neoplasm derived from pluripotential mesenchymal stem cells or endothelial cells of blood vessels. (M-9120/3).
has_obo_namespace: mouse_pathology.ontology
has_related_synonym: Hemangioma malignant
has_related_synonym: hemangioendothelioma malignant, angiosarcoma
has_related_synonym: hemangioendothelioma malignant.
id: MPATH:242

Axiom
annotated source: hemangiosarcoma
annotated property: definition
annotated target: Malignant neoplasm derived from pluripotential mesenchymal stem cells or endothelial cells of blood vessels. (M-9120/3).
database_cross_reference: PMID:8569146

Axiom
annotated source: hemangiosarcoma
annotated property: has_related_synonym
annotated target: Hemangioma malignant
database_cross_reference: Pathbase: Curation

Axiom
annotated source: hemangiosarcoma
annotated property: has_related_synonym
annotated target: hemangioendothelioma malignant, angiosarcoma
database_cross_reference: Pathbase: Curation

Axiom
annotated source: hemangiosarcoma
annotated property: has_related_synonym
annotated target: hemangioendothelioma malignant.
database_cross_reference: Pathbase: Curation

central nervous system tumor
type: Class
subclass of: neoplasm
definition: Neoplasm of the neurones, glia or meninges of the CNS.
has_obo_namespace: mouse_pathology.ontology
id: MPATH:243

Axiom
annotated source: central nervous system tumor
annotated property: definition
annotated target: Neoplasm of the neurones, glia or meninges of the CNS.
database_cross_reference: Pathbase: Curation

astrocytoma
type: Class
subclass of: glioma
definition: Glioma derived from astrocytes, both benign and malignant forms (M-9400/3).
has_obo_namespace: mouse_pathology.ontology
has_related_synonym: Astrocytic glioma
has_related_synonym: astroglioma
id: MPATH:244
comment: Also see comments in Weiss, W.W, Israel, M. Cobbs, C., et al. (2002) Oncogene 21, 7453-7463.

Axiom
annotated source: astrocytoma
annotated property: definition
annotated target: Glioma derived from astrocytes, both benign and malignant forms (M-9400/3).
database_cross_reference: ISBN-13:9783794515530

Axiom
annotated source: astrocytoma
annotated property: has_related_synonym
annotated target: Astrocytic glioma
database_cross_reference: Pathbase: Curation

Axiom
annotated source: astrocytoma
annotated property: has_related_synonym
annotated target: astroglioma
database_cross_reference: Pathbase: Curation

choroid plexus carcinoma
type: Class
subclass of: carcinoma
subclass of: tumors of neurepithelial tissue
definition: Malignant neoplasm derived from the epithelial cells of the choroid plexus. (M-9390/3).
has_obo_namespace: mouse_pathology.ontology
id: MPATH:245

Axiom
annotated source: choroid plexus carcinoma
annotated property: definition
annotated target: Malignant neoplasm derived from the epithelial cells of the choroid plexus. (M-9390/3).
database_cross_reference: ISBN-13:9783794515530

choroid plexus papilloma
type: Class
subclass of: fibroepithelial tumor
subclass of: tumors of neurepithelial tissue
definition: Benign neoplasm derived from the epithelial cells of the choroid plexus. (M-9390/0).
has_obo_namespace: mouse_pathology.ontology
id: MPATH:246

Axiom
annotated source: choroid plexus papilloma
annotated property: definition
annotated target: Benign neoplasm derived from the epithelial cells of the choroid plexus. (M-9390/0).
database_cross_reference: ISBN-13:9783794515530

ependymoma
type: Class
subclass of: glioma
definition: Neoplasm derived from the ependymal cells lining the ventricles and aqueduct of the brain and the central canal of the spinal cord. Malignant or benign. (M-9391/3).
has_obo_namespace: mouse_pathology.ontology
id: MPATH:247
comment: Also see general scheme in Weiss, W.W, Israel, M. Cobbs, C., et al. (2002) Oncogene 21, 7453-7463.

Axiom
annotated source: ependymoma
annotated property: definition
annotated target: Neoplasm derived from the ependymal cells lining the ventricles and aqueduct of the brain and the central canal of the spinal cord. Malignant or benign. (M-9391/3).
database_cross_reference: ISBN-13:9783794515530

ependymoma malignant
type: Class
definition: ependymoma malignant
has_obo_namespace: mouse_pathology.ontology
id: MPATH:248
comment: obsolete -subsumed into MPATH:247
deprecated: true

Axiom
annotated source: ependymoma malignant
annotated property: definition
annotated target: ependymoma malignant
database_cross_reference: Pathbase: Curation

glioma
type: Class
subclass of: tumors of neurepithelial tissue
definition: Neoplasm derived from astrocytes and oligodendrocytes. (M-9380/3, M-9440/3).
has_obo_namespace: mouse_pathology.ontology
id: MPATH:249
comment: Also see comments in: Weiss, W.W, Israel, M. Cobbs, C., et al. (2002) Oncogene 21, 7453-7463.

Axiom
annotated source: glioma
annotated property: definition
annotated target: Neoplasm derived from astrocytes and oligodendrocytes. (M-9380/3, M-9440/3).
database_cross_reference: ISBN-13:9783794515530

tissue specific degenerative process
type: Class
subclass of: process of degenerative change
definition: Degenerative process characteristic of a particular tissue.
has_obo_namespace: mouse_pathology.ontology
id: MPATH:25

Axiom
annotated source: tissue specific degenerative process
annotated property: definition
annotated target: Degenerative process characteristic of a particular tissue.
database_cross_reference: Pathbase: Curation

medulloblastoma
type: Class
subclass of: CNS progenitor tumor
definition: Neoplasm derived from the primitive neurectodermal cells of the cerebellum. (M-9470/3). May be considered by some authorities a synonym of PNET in the CNS.
has_obo_namespace: mouse_pathology.ontology
id: MPATH:250
comment: Also see Weiss, W.W, Israel, M. Cobbs, C., et al. (2002) Oncogene 21, 7453-7463.

Axiom
annotated source: medulloblastoma
annotated property: definition
annotated target: Neoplasm derived from the primitive neurectodermal cells of the cerebellum. (M-9470/3). May be considered by some authorities a synonym of PNET in the CNS.
database_cross_reference: ISBN-13:9783794515530

meningioma
type: Class
subclass of: tumors of the meninges
definition: meningioma
has_obo_namespace: mouse_pathology.ontology
has_related_synonym: Sarcoma, meningeal ( sensu malignant tumor)
id: MPATH:251
comment: Benign or malignant neoplasm derived from the meninges. (M-9530/0).

Axiom
annotated source: meningioma
annotated property: definition
annotated target: meningioma
database_cross_reference: ISBN-13:9783794515530

Axiom
annotated source: meningioma
annotated property: has_related_synonym
annotated target: Sarcoma, meningeal ( sensu malignant tumor)
database_cross_reference: Pathbase: Curation

oligodendroglioma
type: Class
subclass of: glioma
definition: Benign or malignant neoplasm derived form oligodendrocytes (M-9450/3).
has_obo_namespace: mouse_pathology.ontology
has_related_synonym: Glioma, oligodendritic, benign
has_related_synonym: glioma oligodendritic, malignant
id: MPATH:252
comment: Also see Weiss, W.W, Israel, M. Cobbs, C., et al. (2002) Oncogene 21, 7453-7463.

Axiom
annotated source: oligodendroglioma
annotated property: definition
annotated target: Benign or malignant neoplasm derived form oligodendrocytes (M-9450/3).
database_cross_reference: ISBN-13:9783794515530

Axiom
annotated source: oligodendroglioma
annotated property: has_related_synonym
annotated target: Glioma, oligodendritic, benign
database_cross_reference: Pathbase: Curation

Axiom
annotated source: oligodendroglioma
annotated property: has_related_synonym
annotated target: glioma oligodendritic, malignant
database_cross_reference: Pathbase: Curation

sub-ependymoma
type: Class
subclass of: glioma
definition: Neoplasm derived from sub-ependymal astrocytes (M-9383/1).
has_obo_namespace: mouse_pathology.ontology
id: MPATH:253
comment: Also see general scheme in Weiss, W.W, Israel, M. Cobbs, C., et al. (2002) Oncogene 21, 7453-7463.

Axiom
annotated source: sub-ependymoma
annotated property: definition
annotated target: Neoplasm derived from sub-ependymal astrocytes (M-9383/1).
database_cross_reference: ISBN-13:9783794515530

complex tumor
type: Class
subclass of: neoplasm
definition: Tumors showing multiple histological componants/differentiation.
has_obo_namespace: mouse_pathology.ontology
id: MPATH:254

Axiom
annotated source: complex tumor
annotated property: definition
annotated target: Tumors showing multiple histological componants/differentiation.
database_cross_reference: Pathbase: Pathology Committee

adenoacanthoma
type: Class
subclass of: complex tumor
definition: Mixed tumor of glandular epithelia with squamous and glandular diffferentiation. (M-8570/3).
has_obo_namespace: mouse_pathology.ontology
has_related_synonym: adenoid squamous cell carcinoma
id: MPATH:255

Axiom
annotated source: adenoacanthoma
annotated property: definition
annotated target: Mixed tumor of glandular epithelia with squamous and glandular diffferentiation. (M-8570/3).
database_cross_reference: Pathbase: Curation

Axiom
annotated source: adenoacanthoma
annotated property: has_related_synonym
annotated target: adenoid squamous cell carcinoma
database_cross_reference: Pathbase: Curation

carcinosarcoma
type: Class
subclass of: complex tumor
subclass of: carcinoma
subclass of: sarcoma
definition: Possible origin from smooth muscle cells or pluripotential embryonic mesenchymal cells. May show up to three cellular componants including carcinoma and sarcoma type appearances. (M-8980/3).
has_obo_namespace: mouse_pathology.ontology
id: MPATH:256

Axiom
annotated source: carcinosarcoma
annotated property: definition
annotated target: Possible origin from smooth muscle cells or pluripotential embryonic mesenchymal cells. May show up to three cellular componants including carcinoma and sarcoma type appearances. (M-8980/3).
database_cross_reference: Pathbase: Curation

craniopharyngioma
type: Class
subclass of: complex tumor
definition: A benign or malignant neoplasm, which may be cystic, developing from the epithelium of Rathke`s pouch and occuring with or close to the pituitary gland. (M-9350/1).
has_obo_namespace: mouse_pathology.ontology
has_related_synonym: Erdheim tumor
has_related_synonym: Pituitary adamantinoma
has_related_synonym: Rathke pouch tumor
has_related_synonym: pituitary ameloblastoma
has_related_synonym: suprasellar cyst
id: MPATH:257

Axiom
annotated source: craniopharyngioma
annotated property: definition
annotated target: A benign or malignant neoplasm, which may be cystic, developing from the epithelium of Rathke`s pouch and occuring with or close to the pituitary gland. (M-9350/1).
database_cross_reference: Pathbase: Pathology Committee

Axiom
annotated source: craniopharyngioma
annotated property: has_related_synonym
annotated target: Erdheim tumor
database_cross_reference: Pathbase: Curation

Axiom
annotated source: craniopharyngioma
annotated property: has_related_synonym
annotated target: Pituitary adamantinoma
database_cross_reference: Pathbase: Curation

Axiom
annotated source: craniopharyngioma
annotated property: has_related_synonym
annotated target: Rathke pouch tumor
database_cross_reference: Pathbase: Curation

Axiom
annotated source: craniopharyngioma
annotated property: has_related_synonym
annotated target: pituitary ameloblastoma
database_cross_reference: Pathbase: Curation

Axiom
annotated source: craniopharyngioma
annotated property: has_related_synonym
annotated target: suprasellar cyst
database_cross_reference: Pathbase: Curation

mesodermal mixed tumor
type: Class
subclass of: complex tumor
definition: Neoplasm showing multiple phases, derived from mesoderm (M-8951/3).
has_obo_namespace: mouse_pathology.ontology
id: MPATH:258

Axiom
annotated source: mesodermal mixed tumor
annotated property: definition
annotated target: Neoplasm showing multiple phases, derived from mesoderm (M-8951/3).
database_cross_reference: Pathbase: Curation

mucoepidermoid carcinoma
type: Class
subclass of: complex tumor
definition: Most commonly a salivary gland carcinoma of low grade malignancy composed of mucous, epidermoid, and intermediate cells. (M-8430/3).
has_obo_namespace: mouse_pathology.ontology
id: MPATH:259

Axiom
annotated source: mucoepidermoid carcinoma
annotated property: definition
annotated target: Most commonly a salivary gland carcinoma of low grade malignancy composed of mucous, epidermoid, and intermediate cells. (M-8430/3).
database_cross_reference: Pathbase: Curation

alopecia
type: Class
subclass of: tissue specific degenerative process
definition: Absence of hair or loss of hair.
has_obo_namespace: mouse_pathology.ontology
id: MPATH:26

Axiom
annotated source: alopecia
annotated property: definition
annotated target: Absence of hair or loss of hair.
database_cross_reference: ISBN:0781727286

mullerian mixed tumor
type: Class
subclass of: complex tumor
definition: Neoplasm usually of the uterus or adnexae containing carcinomatous and sarcomatous elements, sometimes with third or fourth components. (M-8950/3).
has_obo_namespace: mouse_pathology.ontology
id: MPATH:260

Axiom
annotated source: mullerian mixed tumor
annotated property: definition
annotated target: Neoplasm usually of the uterus or adnexae containing carcinomatous and sarcomatous elements, sometimes with third or fourth components. (M-8950/3).
database_cross_reference: Pathbase: Pathology Committee

nephroblastoma
type: Class
subclass of: complex tumor
definition: Embryonal tumor thought to be derived from metanephric blastema. Mono, bi or triphasic, sometimes with heterotypic differentiation. (M-8960/3).
has_obo_namespace: mouse_pathology.ontology
has_related_synonym: nephroma
id: MPATH:261

Axiom
annotated source: nephroblastoma
annotated property: definition
annotated target: Embryonal tumor thought to be derived from metanephric blastema. Mono, bi or triphasic, sometimes with heterotypic differentiation. (M-8960/3).
database_cross_reference: Pathbase: Pathology Committee

Axiom
annotated source: nephroblastoma
annotated property: has_related_synonym
annotated target: nephroma
database_cross_reference: Pathbase: Curation

pulmonary blastoma
type: Class
subclass of: complex tumor
definition: A biphasic tumor containing a primitive epithelial component, that may resemble well-differentiated fetal adenocarcinoma and a primitive mesenchymal stroma, which occasionally has foci of osteosarcoma, chondrosarcoma or rhadomyosarcoma. (M-8972/3).
has_obo_namespace: mouse_pathology.ontology
id: MPATH:262

Axiom
annotated source: pulmonary blastoma
annotated property: definition
annotated target: A biphasic tumor containing a primitive epithelial component, that may resemble well-differentiated fetal adenocarcinoma and a primitive mesenchymal stroma, which occasionally has foci of osteosarcoma, chondrosarcoma or rhadomyosarcoma. (M-8972/3).
database_cross_reference: Pathbase: Pathology Committee

rhabdoid sarcoma
type: Class
subclass of: complex tumor
subclass of: sarcoma
definition: Sarcomatous tumors, presenting a wide histological, ultrastructural, and immunocytochemical spectrum. M-8963/3.
has_obo_namespace: mouse_pathology.ontology
has_related_synonym: Malignant rhabdoid tumor
id: MPATH:263

Axiom
annotated source: rhabdoid sarcoma
annotated property: definition
annotated target: Sarcomatous tumors, presenting a wide histological, ultrastructural, and immunocytochemical spectrum. M-8963/3.
database_cross_reference: Pathbase: Curation

Axiom
annotated source: rhabdoid sarcoma
annotated property: has_related_synonym
annotated target: Malignant rhabdoid tumor
database_cross_reference: Pathbase: Curation

fibroepithelial tumor
type: Class
subclass of: neoplasm
definition: Tumors with epithelial invaginations/linings and a fibrillary and fibrocytic stroma. (M-9000 - M-9030).
has_obo_namespace: mouse_pathology.ontology
id: MPATH:264

Axiom
annotated source: fibroepithelial tumor
annotated property: definition
annotated target: Tumors with epithelial invaginations/linings and a fibrillary and fibrocytic stroma. (M-9000 - M-9030).
database_cross_reference: Pathbase: Curation

adenofibroma
type: Class
subclass of: fibroepithelial tumor
definition: A benign neoplasm composed of glandular and fibrous tissues, predominantly glandular. (M-9013/0).
has_obo_namespace: mouse_pathology.ontology
has_related_synonym: Cystadenofibroma
has_related_synonym: papillary adenofibroma
id: MPATH:265

Axiom
annotated source: adenofibroma
annotated property: definition
annotated target: A benign neoplasm composed of glandular and fibrous tissues, predominantly glandular. (M-9013/0).
database_cross_reference: Pathbase: Curation

Axiom
annotated source: adenofibroma
annotated property: has_related_synonym
annotated target: Cystadenofibroma
database_cross_reference: Pathbase: Curation

Axiom
annotated source: adenofibroma
annotated property: has_related_synonym
annotated target: papillary adenofibroma
database_cross_reference: Pathbase: Curation

fibroadenoma
type: Class
subclass of: fibroepithelial tumor
definition: A benign neoplasm derived from glandular epithelium, in which there is a abundant stroma of proliferating fibroblasts and connective tissue. (M-9010/0).
has_obo_namespace: mouse_pathology.ontology
id: MPATH:266

Axiom
annotated source: fibroadenoma
annotated property: definition
annotated target: A benign neoplasm derived from glandular epithelium, in which there is a abundant stroma of proliferating fibroblasts and connective tissue. (M-9010/0).
database_cross_reference: Pathbase: Curation

glandular tumor
type: Class
subclass of: neoplasm
definition: Neoplasms derived from glandular epithelial cells.
has_obo_namespace: mouse_pathology.ontology
id: MPATH:267

Axiom
annotated source: glandular tumor
annotated property: definition
annotated target: Neoplasms derived from glandular epithelial cells.
database_cross_reference: Pathbase: Curation

adenocarcinoma
type: Class
subclass of: glandular tumor
subclass of: carcinoma
definition: Malignant neoplasm of epithelial cells in glandular or glandlike pattern. (M-8140/3).
has_obo_namespace: mouse_pathology.ontology
id: MPATH:268

Axiom
annotated source: adenocarcinoma
annotated property: definition
annotated target: Malignant neoplasm of epithelial cells in glandular or glandlike pattern. (M-8140/3).
database_cross_reference: Pathbase: Curation

adenocarcinoma in situ
type: Class
subclass of: adenocarcinoma
subclass of: potentially cancerous lesions
definition: A noninvasive abnormal proliferation of glands believed to precede the appearance of invasive adenocarcinoma. (M-8140/2).
has_obo_namespace: mouse_pathology.ontology
id: MPATH:269

Axiom
annotated source: adenocarcinoma in situ
annotated property: definition
annotated target: A noninvasive abnormal proliferation of glands believed to precede the appearance of invasive adenocarcinoma. (M-8140/2).
database_cross_reference: Pathbase: Pathology Committee

arthrosis
type: Class
subclass of: tissue specific degenerative process
definition: Changes characterized by erosion of articular cartilage, either primary or secondary to trauma or other conditions. Not primarily an inflammatory process.
has_obo_namespace: mouse_pathology.ontology
has_related_synonym: Degenerative joint disease
has_related_synonym: osteoarthrosis
id: MPATH:27

Axiom
annotated source: arthrosis
annotated property: definition
annotated target: Changes characterized by erosion of articular cartilage, either primary or secondary to trauma or other conditions. Not primarily an inflammatory process.
database_cross_reference: ISBN:0781727286

Axiom
annotated source: arthrosis
annotated property: has_related_synonym
annotated target: Degenerative joint disease
database_cross_reference: Pathbase: Curation

Axiom
annotated source: arthrosis
annotated property: has_related_synonym
annotated target: osteoarthrosis
database_cross_reference: Pathbase: Curation

adenoma
type: Class
subclass of: glandular tumor
subclass of: potentially cancerous lesions
definition: A benign epithelial neoplasm in which the tumor cells may form glands or glandlike structures. In different instances this may remain a benign tumor or progress to malignancy.
has_obo_namespace: mouse_pathology.ontology
id: MPATH:270

Axiom
annotated source: adenoma
annotated property: definition
annotated target: A benign epithelial neoplasm in which the tumor cells may form glands or glandlike structures. In different instances this may remain a benign tumor or progress to malignancy.
database_cross_reference: Pathbase: Pathology Committee

adenomatous polyposis coli
type: Class
subclass of: glandular tumor
subclass of: potentially cancerous lesions
definition: Spontaneous intestinal adenoma formation. Polyps increase in number, causing symptoms of chronic colitis and potentially transform into adenocarcinoma. (M-8220/0).
has_obo_namespace: mouse_pathology.ontology
id: MPATH:271

Axiom
annotated source: adenomatous polyposis coli
annotated property: definition
annotated target: Spontaneous intestinal adenoma formation. Polyps increase in number, causing symptoms of chronic colitis and potentially transform into adenocarcinoma. (M-8220/0).
database_cross_reference: Pathbase: Curation

bronchioloalveolar adenoma
type: Class
subclass of: adenoma
definition: Benign epithelial neoplasm of the lung. (M-8140/1) 1.2.1.2 in MMHCC classification.
database_cross_reference: URL: http://emice.nci.nih.gov/mouse_models/organ_models/lung_models/murinecancer/tumorclass
has_obo_namespace: mouse_pathology.ontology
has_related_synonym: Bronchial adenoma
has_related_synonym: Bronchial adenoma, BA adenoma
id: MPATH:272

Axiom
annotated source: bronchioloalveolar adenoma
annotated property: definition
annotated target: Benign epithelial neoplasm of the lung. (M-8140/1) 1.2.1.2 in MMHCC classification.
database_cross_reference: PMID:15059877

Axiom
annotated source: bronchioloalveolar adenoma
annotated property: has_related_synonym
annotated target: Bronchial adenoma
database_cross_reference: Pathbase: Curation

Axiom
annotated source: bronchioloalveolar adenoma
annotated property: has_related_synonym
annotated target: Bronchial adenoma, BA adenoma
database_cross_reference: Pathbase: Curation

bronchioloalveolar carcinoma
type: Class
subclass of: adenocarcinoma
subclass of: carcinoma
definition: Malignant epithelial neoplasm of the lung. (M-8250/3) 1.2.3.2, 1.2.3.5 of MMHCC classification.
database_cross_reference: URL: http://emice.nci.nih.gov/mouse_models/organ_models/lung_models/murinecancer/tumorclass
has_obo_namespace: mouse_pathology.ontology
has_related_synonym: Bronchioloalveolar adenocarcinoma
has_related_synonym: Bronchioloalveolar adenocarcinoma, bronchioalveolar carcinoma
id: MPATH:273

Axiom
annotated source: bronchioloalveolar carcinoma
annotated property: definition
annotated target: Malignant epithelial neoplasm of the lung. (M-8250/3) 1.2.3.2, 1.2.3.5 of MMHCC classification.
database_cross_reference: PMID:15059877

Axiom
annotated source: bronchioloalveolar carcinoma
annotated property: has_related_synonym
annotated target: Bronchioloalveolar adenocarcinoma
database_cross_reference: Pathbase: Curation

Axiom
annotated source: bronchioloalveolar carcinoma
annotated property: has_related_synonym
annotated target: Bronchioloalveolar adenocarcinoma, bronchioalveolar carcinoma
database_cross_reference: Pathbase: Curation

clear cell adenocarcinoma
type: Class
subclass of: adenocarcinoma
definition: An adenocarcinoma characterised by the presence of varying combinations of clear and hobnail-shaped tumor cells. (M-8310/3).
has_obo_namespace: mouse_pathology.ontology
id: MPATH:274

Axiom
annotated source: clear cell adenocarcinoma
annotated property: definition
annotated target: An adenocarcinoma characterised by the presence of varying combinations of clear and hobnail-shaped tumor cells. (M-8310/3).
database_cross_reference: Pathbase: Curation

comedocarcinoma
type: Class
subclass of: glandular tumor
subclass of: carcinoma
definition: Form of carcinoma of the breast or other organ in which plugs of necrotic malignant cells are present in the ducts. (M -8501/3).
has_obo_namespace: mouse_pathology.ontology
id: MPATH:275

Axiom
annotated source: comedocarcinoma
annotated property: definition
annotated target: Form of carcinoma of the breast or other organ in which plugs of necrotic malignant cells are present in the ducts. (M -8501/3).
database_cross_reference: Pathbase: Pathology Committee

cystadenocarcinoma
type: Class
subclass of: adenocarcinoma
definition: Malignant neoplasm derived from glandular epithelium, in which cystic accumulations of retained secretions are formed. (M-8440/3).
has_obo_namespace: mouse_pathology.ontology
id: MPATH:276

Axiom
annotated source: cystadenocarcinoma
annotated property: definition
annotated target: Malignant neoplasm derived from glandular epithelium, in which cystic accumulations of retained secretions are formed. (M-8440/3).
database_cross_reference: Pathbase: Curation

cystadenoma
type: Class
subclass of: adenoma
definition: A benign neoplasm derived from glandular epithelium, in which cystic accumulations of retained secretions are formed. (M-8440/0).
has_obo_namespace: mouse_pathology.ontology
id: MPATH:277

Axiom
annotated source: cystadenoma
annotated property: definition
annotated target: A benign neoplasm derived from glandular epithelium, in which cystic accumulations of retained secretions are formed. (M-8440/0).
database_cross_reference: Pathbase: Pathology Committee

follicular adenocarcinoma
type: Class
subclass of: adenocarcinoma
definition: Originates in the follicular cells of thyroid follicles. Papillary, solid and follicular forms. (M- 8330/3).
has_obo_namespace: mouse_pathology.ontology
has_related_synonym: Follicular carcinoma
id: MPATH:278

Axiom
annotated source: follicular adenocarcinoma
annotated property: definition
annotated target: Originates in the follicular cells of thyroid follicles. Papillary, solid and follicular forms. (M- 8330/3).
database_cross_reference: Pathbase: Curation

Axiom
annotated source: follicular adenocarcinoma
annotated property: has_related_synonym
annotated target: Follicular carcinoma
database_cross_reference: Pathbase: Curation

follicular adenoma
type: Class
subclass of: adenoma
definition: Adenoma derived from the follicular cells of the thyroid follicles. Follicular, paipillary and solid forms. M- 8330/0.
has_obo_namespace: mouse_pathology.ontology
id: MPATH:279

Axiom
annotated source: follicular adenoma
annotated property: definition
annotated target: Adenoma derived from the follicular cells of the thyroid follicles. Follicular, paipillary and solid forms. M- 8330/0.
database_cross_reference: Pathbase: Curation

atherosclerosis
type: Class
subclass of: tissue specific degenerative process
definition: Characterised by irregular lipid deposits in the wall of arteries, causing narrowing of their lumens and proceeding eventually to fibrosis and calcification.
has_obo_namespace: mouse_pathology.ontology
id: MPATH:28
comment: Note that in mouse and rats the initial lesions are mostly in the medial layer while in human they occur in the intima.

Axiom
annotated source: atherosclerosis
annotated property: definition
annotated target: Characterised by irregular lipid deposits in the wall of arteries, causing narrowing of their lumens and proceeding eventually to fibrosis and calcification.
database_cross_reference: Pathbase: Pathology Committee

Harderian gland adenoma
type: Class
subclass of: adenoma
definition: Adenoma derived from acinar epithelium of the harderian gland. Papillary, cystic, cystic-papillary and acinar forms.
has_obo_namespace: mouse_pathology.ontology
id: MPATH:280

Axiom
annotated source: Harderian gland adenoma
annotated property: definition
annotated target: Adenoma derived from acinar epithelium of the harderian gland. Papillary, cystic, cystic-papillary and acinar forms.
database_cross_reference: Pathbase: Pathology Committee

Harderian gland carcinoma
type: Class
subclass of: glandular tumor
subclass of: carcinoma
definition: Malignant tumor derived form acinar epithelium of the Harderian gland.
has_obo_namespace: mouse_pathology.ontology
id: MPATH:281

Axiom
annotated source: Harderian gland carcinoma
annotated property: definition
annotated target: Malignant tumor derived form acinar epithelium of the Harderian gland.
database_cross_reference: Pathbase: Pathology Committee

infiltrating duct carcinoma
type: Class
subclass of: adenocarcinoma
subclass of: carcinoma
definition: Derived from the mammary ductal epithelium and penetrating the stroma (M-8500/3).
has_obo_namespace: mouse_pathology.ontology
has_related_synonym: Infiltrating ductal adenocarcinoma
has_related_synonym: duct adenocarcinoma
has_related_synonym: ductal carcinoma
id: MPATH:282

Axiom
annotated source: infiltrating duct carcinoma
annotated property: definition
annotated target: Derived from the mammary ductal epithelium and penetrating the stroma (M-8500/3).
database_cross_reference: Pathbase: Pathology Committee

Axiom
annotated source: infiltrating duct carcinoma
annotated property: has_related_synonym
annotated target: Infiltrating ductal adenocarcinoma
database_cross_reference: Pathbase: Curation

Axiom
annotated source: infiltrating duct carcinoma
annotated property: has_related_synonym
annotated target: duct adenocarcinoma
database_cross_reference: Pathbase: Curation

Axiom
annotated source: infiltrating duct carcinoma
annotated property: has_related_synonym
annotated target: ductal carcinoma
database_cross_reference: Pathbase: Curation

intraductal carcinoma
type: Class
definition: In situ carcinoma of the mammary ductal epithelium. (M- 8500/2).
has_obo_namespace: mouse_pathology.ontology
has_related_synonym: Ductal carcinoma in situ
has_related_synonym: intraductal adenocarcinoma, non-infiltrating
id: MPATH:283
comment: Made obsolete by inclusion in MPATH: 486 Ductal intra-epithelial neoplasia
deprecated: true

Axiom
annotated source: intraductal carcinoma
annotated property: definition
annotated target: In situ carcinoma of the mammary ductal epithelium. (M- 8500/2).
database_cross_reference: Pathbase: Curation

Axiom
annotated source: intraductal carcinoma
annotated property: has_related_synonym
annotated target: Ductal carcinoma in situ
database_cross_reference: Pathbase: Curation

Axiom
annotated source: intraductal carcinoma
annotated property: has_related_synonym
annotated target: intraductal adenocarcinoma, non-infiltrating
database_cross_reference: Pathbase: Curation

intraductal papillary carcinoma
type: Class
subclass of: glandular tumor
subclass of: carcinoma
definition: Infiltrating tumor with papillary morphology derived from the breast epithelium (M-8503/3).
has_obo_namespace: mouse_pathology.ontology
has_related_synonym: Intraductal papillary adenocarcinoma
id: MPATH:284

Axiom
annotated source: intraductal papillary carcinoma
annotated property: definition
annotated target: Infiltrating tumor with papillary morphology derived from the breast epithelium (M-8503/3).
database_cross_reference: Pathbase: Curation

Axiom
annotated source: intraductal papillary carcinoma
annotated property: has_related_synonym
annotated target: Intraductal papillary adenocarcinoma
database_cross_reference: Pathbase: Curation

intraductal papilloma
type: Class
subclass of: glandular tumor
subclass of: papilloma
subclass of: Restriction
  on property: part of
  some values from: intraductal papillomatosis
definition: Benign papilloma arising from ductal epithelium (M- 8503/0 ).
has_obo_namespace: mouse_pathology.ontology
has_related_synonym: Duct adenoma
has_related_synonym: ductal papilloma
id: MPATH:285

Axiom
annotated source: intraductal papilloma
annotated property: definition
annotated target: Benign papilloma arising from ductal epithelium (M- 8503/0 ).
database_cross_reference: Pathbase: Curation

Axiom
annotated source: intraductal papilloma
annotated property: has_related_synonym
annotated target: Duct adenoma
database_cross_reference: Pathbase: Curation

Axiom
annotated source: intraductal papilloma
annotated property: has_related_synonym
annotated target: ductal papilloma
database_cross_reference: Pathbase: Curation

intraductal papillomatosis
type: Class
subclass of: glandular tumor
definition: Diffuse multiple adenomatous papillomas derived from the ductal epithelium of the breast. (M- 8505/0).
has_obo_namespace: mouse_pathology.ontology
has_related_synonym: Diffuse intraductal papillomatosis
id: MPATH:286

Axiom
annotated source: intraductal papillomatosis
annotated property: definition
annotated target: Diffuse multiple adenomatous papillomas derived from the ductal epithelium of the breast. (M- 8505/0).
database_cross_reference: Pathbase: Curation

Axiom
annotated source: intraductal papillomatosis
annotated property: has_related_synonym
annotated target: Diffuse intraductal papillomatosis
database_cross_reference: Pathbase: Curation

islet cell adenoma
type: Class
subclass of: adenoma
definition: Usually pancreatic B cell derived tumors mostly producing insulin. (M- 8150/0).
has_obo_namespace: mouse_pathology.ontology
has_related_synonym: Adenoma, endocrine pancreas
has_related_synonym: adenomatosis
has_related_synonym: islet (pancreatic) cell tumor benign
id: MPATH:287

Axiom
annotated source: islet cell adenoma
annotated property: definition
annotated target: Usually pancreatic B cell derived tumors mostly producing insulin. (M- 8150/0).
database_cross_reference: Pathbase: Curation

Axiom
annotated source: islet cell adenoma
annotated property: has_related_synonym
annotated target: Adenoma, endocrine pancreas
database_cross_reference: Pathbase: Curation

Axiom
annotated source: islet cell adenoma
annotated property: has_related_synonym
annotated target: adenomatosis
database_cross_reference: Pathbase: Curation

Axiom
annotated source: islet cell adenoma
annotated property: has_related_synonym
annotated target: islet (pancreatic) cell tumor benign
database_cross_reference: Pathbase: Curation

islet cell carcinoma
type: Class
subclass of: glandular tumor
subclass of: carcinoma
definition: Rare tumor of the islets of Langerhans, most of which produce insulin. (M- 8150/3).
has_obo_namespace: mouse_pathology.ontology
has_related_synonym: Adenocarcinoma, endocrine pancreas
has_related_synonym: islet cell tumor, malignant
id: MPATH:288

Axiom
annotated source: islet cell carcinoma
annotated property: definition
annotated target: Rare tumor of the islets of Langerhans, most of which produce insulin. (M- 8150/3).
database_cross_reference: Pathbase: Pathology Committee

Axiom
annotated source: islet cell carcinoma
annotated property: has_related_synonym
annotated target: Adenocarcinoma, endocrine pancreas
database_cross_reference: Pathbase: Curation

Axiom
annotated source: islet cell carcinoma
annotated property: has_related_synonym
annotated target: islet cell tumor, malignant
database_cross_reference: Pathbase: Curation

lobular carcinoma
type: Class
subclass of: glandular tumor
subclass of: carcinoma
definition: A form of breast adenocarcinoma derived from lobular cells. (M-8520/3).
has_obo_namespace: mouse_pathology.ontology
has_related_synonym: Lobular adenocarcinoma
has_related_synonym: lobular infiltrating carcinoma
id: MPATH:289

Axiom
annotated source: lobular carcinoma
annotated property: definition
annotated target: A form of breast adenocarcinoma derived from lobular cells. (M-8520/3).
database_cross_reference: Pathbase: Curation

Axiom
annotated source: lobular carcinoma
annotated property: has_related_synonym
annotated target: Lobular adenocarcinoma
database_cross_reference: Pathbase: Curation

Axiom
annotated source: lobular carcinoma
annotated property: has_related_synonym
annotated target: lobular infiltrating carcinoma
database_cross_reference: Pathbase: Curation

cataract
type: Class
subclass of: cell and tissue damage
definition: Opacity of the lens.
has_obo_namespace: mouse_pathology.ontology
id: MPATH:29

Axiom
annotated source: cataract
annotated property: definition
annotated target: Opacity of the lens.
database_cross_reference: PMID:9309781

lobular carcinoma in situ
type: Class
subclass of: glandular tumor
subclass of: potentially cancerous lesions
definition: Non-infiltrating form of lobular adenocarcinoma derived from the ductal epithelium. (M-8520/2).
has_obo_namespace: mouse_pathology.ontology
has_related_synonym: mammary intra-epithelial neoplasia
id: MPATH:290

Axiom
annotated source: lobular carcinoma in situ
annotated property: definition
annotated target: Non-infiltrating form of lobular adenocarcinoma derived from the ductal epithelium. (M-8520/2).
database_cross_reference: ISBN:0781727286

Axiom
annotated source: lobular carcinoma in situ
annotated property: has_related_synonym
annotated target: mammary intra-epithelial neoplasia
database_cross_reference: Pathbase: Curation

medullary carcinoma
type: Class
subclass of: glandular tumor
subclass of: carcinoma
definition: Derived from calcitonin-producing cells (thyroid). In humans a type of carcinoma composed of epithelial elements with considerable lymphoid stroma (breast). Not yet reported in mice. (M-8510/3).
has_obo_namespace: mouse_pathology.ontology
has_related_synonym: Medullary adenocarcinoma
id: MPATH:291

Axiom
annotated source: medullary carcinoma
annotated property: definition
annotated target: Derived from calcitonin-producing cells (thyroid). In humans a type of carcinoma composed of epithelial elements with considerable lymphoid stroma (breast). Not yet reported in mice. (M-8510/3).
database_cross_reference: Pathbase: Pathology Committee

Axiom
annotated source: medullary carcinoma
annotated property: has_related_synonym
annotated target: Medullary adenocarcinoma
database_cross_reference: Pathbase: Curation

mucinous cystadenocarcinoma
type: Class
subclass of: cystadenocarcinoma
definition: Malignant neoplasm derived from a glandular epithelium, eg. Ovary. Consisting of a solid to cystic mass lined with cuboidal pleomorphic epithelial cells producing a mucinous material. (M- 8470/3).
has_obo_namespace: mouse_pathology.ontology
id: MPATH:292

Axiom
annotated source: mucinous cystadenocarcinoma
annotated property: definition
annotated target: Malignant neoplasm derived from a glandular epithelium, eg. Ovary. Consisting of a solid to cystic mass lined with cuboidal pleomorphic epithelial cells producing a mucinous material. (M- 8470/3).
database_cross_reference: Pathbase: Pathology Committee

mucinous cystadenoma
type: Class
subclass of: adenoma
definition: A benign neoplasm derived from glandular epithelium, in which cystic accumulations of mucinous retained secretions are formed. (M-8470/0).
has_obo_namespace: mouse_pathology.ontology
id: MPATH:293

Axiom
annotated source: mucinous cystadenoma
annotated property: definition
annotated target: A benign neoplasm derived from glandular epithelium, in which cystic accumulations of mucinous retained secretions are formed. (M-8470/0).
database_cross_reference: Pathbase: Pathology Committee

myoepithelioma
type: Class
subclass of: adnexal and skin appendage tumor
subclass of: adenoma
definition: Tumor originating in myoepithelial cells of exocrine glandular structures; for example mammary gland, salivary gland and preputial/clitoral glands. (M-8982/0).
has_obo_namespace: mouse_pathology.ontology
has_related_synonym: myoepithelial adenoma
id: MPATH:294

Axiom
annotated source: myoepithelioma
annotated property: definition
annotated target: Tumor originating in myoepithelial cells of exocrine glandular structures; for example mammary gland, salivary gland and preputial/clitoral glands. (M-8982/0).
database_cross_reference: Pathbase: Pathology Committee

Axiom
annotated source: myoepithelioma
annotated property: has_related_synonym
annotated target: myoepithelial adenoma
database_cross_reference: Pathbase: Curation

papillary adenocarcinoma
type: Class
subclass of: adenocarcinoma
definition: A malignant neoplasm derived from a glandular epithelium, in which solid tumors show papillary structures projecting onto fibrovascular stroma. (M-8260/3).
has_obo_namespace: mouse_pathology.ontology
id: MPATH:295

Axiom
annotated source: papillary adenocarcinoma
annotated property: definition
annotated target: A malignant neoplasm derived from a glandular epithelium, in which solid tumors show papillary structures projecting onto fibrovascular stroma. (M-8260/3).
database_cross_reference: Pathbase: Pathology Committee

papillary adenoma
type: Class
subclass of: adenoma
definition: A benign neoplasm derived from a glandular epithelium, in which solid tumors show papillary structures projecting onto fibrovascular stroma. (M-8260/0).
has_obo_namespace: mouse_pathology.ontology
id: MPATH:296

Axiom
annotated source: papillary adenoma
annotated property: definition
annotated target: A benign neoplasm derived from a glandular epithelium, in which solid tumors show papillary structures projecting onto fibrovascular stroma. (M-8260/0).
database_cross_reference: Pathbase: Pathology Committee

papillary cystadenocarcinoma
type: Class
subclass of: cystadenocarcinoma
definition: A malignant neoplasm derived from glandular epithelium, in which cysts contain folds or papillary projections into the lumen. (M-8450/3).
has_obo_namespace: mouse_pathology.ontology
id: MPATH:297

Axiom
annotated source: papillary cystadenocarcinoma
annotated property: definition
annotated target: A malignant neoplasm derived from glandular epithelium, in which cysts contain folds or papillary projections into the lumen. (M-8450/3).
database_cross_reference: Pathbase: Pathology Committee

papillary cystadenoma
type: Class
subclass of: adenoma
definition: A benign neoplasm derived from glandular epithelium, in which cysts contain folds or papillary projections into the lumen. (M-8450/0).
has_obo_namespace: mouse_pathology.ontology
id: MPATH:298

Axiom
annotated source: papillary cystadenoma
annotated property: definition
annotated target: A benign neoplasm derived from glandular epithelium, in which cysts contain folds or papillary projections into the lumen. (M-8450/0).
database_cross_reference: Pathbase: Pathology Committee

pinealoma
type: Class
subclass of: glandular tumor
definition: Originating from differentiated cells of the pineal parenchyma. Not to be confused with human pinealoma (syn: germinoma) non-gonadal germ cell tumors found in the pineal believed to be atypical teratomas. May be benign or malignant. If ectopic teratomas/teratocarcinomas use MP322 or MP321. (M-9360/1).
has_obo_namespace: mouse_pathology.ontology
id: MPATH:299

Axiom
annotated source: pinealoma
annotated property: definition
annotated target: Originating from differentiated cells of the pineal parenchyma. Not to be confused with human pinealoma (syn: germinoma) non-gonadal germ cell tumors found in the pineal believed to be atypical teratomas. May be benign or malignant. If ectopic teratomas/teratocarcinomas use MP322 or MP321. (M-9360/1).
database_cross_reference: Pathbase: Pathology Committee

apoptosis
type: Class
subclass of: cell death
definition: Energy dependent cell death induced by intrinsic genetic or developmental programme, or external stimuli such as addition or withdrawal of cytokines or trophic factors, radiation, chemotherapeutic agents etc. Characterised by cell shrinkage, increases in membrane permeability, endonucleolyis and nuclear fragmentation resulting in the formation of rapidly endocytosed apoptotic bodies.
has_obo_namespace: mouse_pathology.ontology
has_related_synonym: programmed cell death
id: MPATH:3

Axiom
annotated source: apoptosis
annotated property: definition
annotated target: Energy dependent cell death induced by intrinsic genetic or developmental programme, or external stimuli such as addition or withdrawal of cytokines or trophic factors, radiation, chemotherapeutic agents etc. Characterised by cell shrinkage, increases in membrane permeability, endonucleolyis and nuclear fragmentation resulting in the formation of rapidly endocytosed apoptotic bodies.
database_cross_reference: Pathbase: Pathology Committee

Axiom
annotated source: apoptosis
annotated property: has_related_synonym
annotated target: programmed cell death
database_cross_reference: Pathbase: Curation

cystic medial necrosis
type: Class
subclass of: necrosis
definition: Loss of muscle fibers and elastin in the media of the aorta, with accumulation of mucopolysaccharide.
has_obo_namespace: mouse_pathology.ontology
has_related_synonym: Erdheim disease
has_related_synonym: Mucoid medial degeneration
has_related_synonym: media necrosis aortae idiopathica cystica
has_related_synonym: media necrosis of the aorta
id: MPATH:30

Axiom
annotated source: cystic medial necrosis
annotated property: definition
annotated target: Loss of muscle fibers and elastin in the media of the aorta, with accumulation of mucopolysaccharide.
database_cross_reference: ISBN:0781727286

Axiom
annotated source: cystic medial necrosis
annotated property: has_related_synonym
annotated target: Erdheim disease
database_cross_reference: Pathbase: Curation

Axiom
annotated source: cystic medial necrosis
annotated property: has_related_synonym
annotated target: Mucoid medial degeneration
database_cross_reference: Pathbase: Curation

Axiom
annotated source: cystic medial necrosis
annotated property: has_related_synonym
annotated target: media necrosis aortae idiopathica cystica
database_cross_reference: Pathbase: Curation

Axiom
annotated source: cystic medial necrosis
annotated property: has_related_synonym
annotated target: media necrosis of the aorta
database_cross_reference: Pathbase: Curation

pineoblastoma
type: Class
subclass of: glandular tumor
definition: Malignant neoplasms which arise from pineoblasts, the primitive pineal stem cells. (M-9362/3).
has_obo_namespace: mouse_pathology.ontology
has_related_synonym: Mixed pineal tumor
has_related_synonym: pineal parenchymal tumor of intermediate differentiation
has_related_synonym: transitional pineal tumor
id: MPATH:300

Axiom
annotated source: pineoblastoma
annotated property: definition
annotated target: Malignant neoplasms which arise from pineoblasts, the primitive pineal stem cells. (M-9362/3).
database_cross_reference: Pathbase: Pathology Committee

Axiom
annotated source: pineoblastoma
annotated property: has_related_synonym
annotated target: Mixed pineal tumor
database_cross_reference: Pathbase: Curation

Axiom
annotated source: pineoblastoma
annotated property: has_related_synonym
annotated target: pineal parenchymal tumor of intermediate differentiation
database_cross_reference: Pathbase: Curation

Axiom
annotated source: pineoblastoma
annotated property: has_related_synonym
annotated target: transitional pineal tumor
database_cross_reference: Pathbase: Curation

pineocytoma
type: Class
subclass of: glandular tumor
definition: A tumor arising in the pineal gland that resembles normal pineal parenchyma. (M-9361/1).
has_obo_namespace: mouse_pathology.ontology
id: MPATH:301

Axiom
annotated source: pineocytoma
annotated property: definition
annotated target: A tumor arising in the pineal gland that resembles normal pineal parenchyma. (M-9361/1).
database_cross_reference: Pathbase: Curation

pituicytoma
type: Class
subclass of: adenoma
definition: Benign tumor derived from the pituicytes ( glial cells of neurohypophysis) (M-8272/0).
has_obo_namespace: mouse_pathology.ontology
has_related_synonym: pituitary adenoma
id: MPATH:302

Axiom
annotated source: pituicytoma
annotated property: definition
annotated target: Benign tumor derived from the pituicytes ( glial cells of neurohypophysis) (M-8272/0).
database_cross_reference: Pathbase: Curation

Axiom
annotated source: pituicytoma
annotated property: has_related_synonym
annotated target: pituitary adenoma
database_cross_reference: Pathbase: Curation

pseudomyxoma peritonei
type: Class
subclass of: glandular tumor
definition: Tumor characterized by extensive spread of a mucin-secreting neoplasm along the peritoneal surfaces (M-8480/6).
has_obo_namespace: mouse_pathology.ontology
id: MPATH:303

Axiom
annotated source: pseudomyxoma peritonei
annotated property: definition
annotated target: Tumor characterized by extensive spread of a mucin-secreting neoplasm along the peritoneal surfaces (M-8480/6).
database_cross_reference: Pathbase: Curation

serous adenocarcinoma
type: Class
subclass of: adenocarcinoma
definition: Adenocarcinoma from a serous gland producing and containing serous proteinaceous secretions (M-8441/3).
has_obo_namespace: mouse_pathology.ontology
id: MPATH:304

Axiom
annotated source: serous adenocarcinoma
annotated property: definition
annotated target: Adenocarcinoma from a serous gland producing and containing serous proteinaceous secretions (M-8441/3).
database_cross_reference: Pathbase: Pathology Committee

serous cystadenoma
type: Class
subclass of: adenoma
definition: Ovarian cystadenoma composed of cells similar to tubal epithelium (M-8441/0).
has_obo_namespace: mouse_pathology.ontology
id: MPATH:305

Axiom
annotated source: serous cystadenoma
annotated property: definition
annotated target: Ovarian cystadenoma composed of cells similar to tubal epithelium (M-8441/0).
database_cross_reference: Pathbase: Curation

signet ring cell carcinoma
type: Class
subclass of: adenocarcinoma
definition: Adenocarcinoma of signet ring type arising from exocrine cells of the gastric mucosa or enterocytes of intestinal mucosa. (M-8490/3).
has_obo_namespace: mouse_pathology.ontology
has_related_synonym: Signet ring cell adenocarcinoma
has_related_synonym: signet ring cell carcinoma
id: MPATH:306

Axiom
annotated source: signet ring cell carcinoma
annotated property: definition
annotated target: Adenocarcinoma of signet ring type arising from exocrine cells of the gastric mucosa or enterocytes of intestinal mucosa. (M-8490/3).
database_cross_reference: PMID:12612914

Axiom
annotated source: signet ring cell carcinoma
annotated property: has_related_synonym
annotated target: Signet ring cell adenocarcinoma
database_cross_reference: Pathbase: Curation

Axiom
annotated source: signet ring cell carcinoma
annotated property: has_related_synonym
annotated target: signet ring cell carcinoma
database_cross_reference: Pathbase: Curation

thyroid C-cell adenoma
type: Class
subclass of: adenoma
definition: Benign neoplasm derived from the calcitonin producing C-cells of the thyroid gland.
has_obo_namespace: mouse_pathology.ontology
has_related_synonym: Adenoma, parafollicular cell
has_related_synonym: tumor c-cell benign
id: MPATH:307

Axiom
annotated source: thyroid C-cell adenoma
annotated property: definition
annotated target: Benign neoplasm derived from the calcitonin producing C-cells of the thyroid gland.
database_cross_reference: Pathbase: Curation

Axiom
annotated source: thyroid C-cell adenoma
annotated property: has_related_synonym
annotated target: Adenoma, parafollicular cell
database_cross_reference: Pathbase: Curation

Axiom
annotated source: thyroid C-cell adenoma
annotated property: has_related_synonym
annotated target: tumor c-cell benign
database_cross_reference: Pathbase: Curation

thyroid C-cell carcinoma
type: Class
subclass of: glandular tumor
subclass of: carcinoma
definition: Malignant neoplasm derived from the calcitonin producing C-cells of the thyroid gland. (M-8510/3, M-8345/3).
has_obo_namespace: mouse_pathology.ontology
has_related_synonym: Medullary carcinoma, parafollicular cell
has_related_synonym: tumor c-cell malignant
id: MPATH:308

Axiom
annotated source: thyroid C-cell carcinoma
annotated property: definition
annotated target: Malignant neoplasm derived from the calcitonin producing C-cells of the thyroid gland. (M-8510/3, M-8345/3).
database_cross_reference: Pathbase: Curation

Axiom
annotated source: thyroid C-cell carcinoma
annotated property: has_related_synonym
annotated target: Medullary carcinoma, parafollicular cell
database_cross_reference: Pathbase: Curation

Axiom
annotated source: thyroid C-cell carcinoma
annotated property: has_related_synonym
annotated target: tumor c-cell malignant
database_cross_reference: Pathbase: Curation

gonadal tumor
type: Class
subclass of: neoplasm
definition: Germ cell and non-germ cell tumors of the testis and ovary.
has_obo_namespace: mouse_pathology.ontology
id: MPATH:309

Axiom
annotated source: gonadal tumor
annotated property: definition
annotated target: Germ cell and non-germ cell tumors of the testis and ovary.
database_cross_reference: Pathbase: Pathology Committee

emphysema
type: Class
subclass of: tissue specific degenerative process
definition: Abnormal accumulation of air in the interstitial connective tissue of a structure. Sensu Lung: Pulmonary emphysema; characterised by abnormal increase in the size of air (alveolar) spaces distal to the terminal bronchiole with degenerative changes in their walls and reduction in their number.
has_obo_namespace: mouse_pathology.ontology
id: MPATH:31

Axiom
annotated source: emphysema
annotated property: definition
annotated target: Abnormal accumulation of air in the interstitial connective tissue of a structure. Sensu Lung: Pulmonary emphysema; characterised by abnormal increase in the size of air (alveolar) spaces distal to the terminal bronchiole with degenerative changes in their walls and reduction in their number.
database_cross_reference: ISBN:0781727286

germ cell tumor
type: Class
subclass of: gonadal tumor
definition: Neoplasms derived from germ cells. May be gonadal or extragonadal and are derived from primordial germ cells.
has_obo_namespace: mouse_pathology.ontology
id: MPATH:310

Axiom
annotated source: germ cell tumor
annotated property: definition
annotated target: Neoplasms derived from germ cells. May be gonadal or extragonadal and are derived from primordial germ cells.
database_cross_reference: Pathbase: Pathology Committee

dermoid cyst
type: Class
subclass of: complex tumor
subclass of: germ cell tumor
subclass of: carcinoma
definition: Cystic ovarian teratomas with different mature cell types (M-9084/3).
has_obo_namespace: mouse_pathology.ontology
id: MPATH:311

Axiom
annotated source: dermoid cyst
annotated property: definition
annotated target: Cystic ovarian teratomas with different mature cell types (M-9084/3).
database_cross_reference: Pathbase: Curation

dysgerminoma
type: Class
subclass of: germ cell tumor
definition: Undifferentiated germ cell tumor of the ovary composed of solid sheets of large polygonal cells with rim of clear cytoplasm (M-9060/3).
has_obo_namespace: mouse_pathology.ontology
has_related_synonym: Seminoma (sensu male)
id: MPATH:312

Axiom
annotated source: dysgerminoma
annotated property: definition
annotated target: Undifferentiated germ cell tumor of the ovary composed of solid sheets of large polygonal cells with rim of clear cytoplasm (M-9060/3).
database_cross_reference: Pathbase: Curation

Axiom
annotated source: dysgerminoma
annotated property: has_related_synonym
annotated target: Seminoma (sensu male)
database_cross_reference: Pathbase: Curation

embryonal carcinoma
type: Class
subclass of: germ cell tumor
subclass of: carcinoma
definition: Germ cell derived malignant neoplasm of the testis or ovary, composed of anaplastic cells with indistinct cellular borders and large ovoid, round, or bean-shaped nuclei that may have large nucleoli. (M-9070/3 ).
has_obo_namespace: mouse_pathology.ontology
id: MPATH:313

Axiom
annotated source: embryonal carcinoma
annotated property: definition
annotated target: Germ cell derived malignant neoplasm of the testis or ovary, composed of anaplastic cells with indistinct cellular borders and large ovoid, round, or bean-shaped nuclei that may have large nucleoli. (M-9070/3 ).
database_cross_reference: Pathbase: Curation

endodermal sinus tumor
type: Class
subclass of: germ cell tumor
subclass of: carcinoma
definition: Germ cell derived tumors resembling parietal or visceral yolk sac endoderm derivatives. Abundant eosinophilic matrix surrounding nests and cords of neoplastic cells. (M-9071-3).
has_obo_namespace: mouse_pathology.ontology
has_related_synonym: Yolk sac carcinoma
id: MPATH:314

Axiom
annotated source: endodermal sinus tumor
annotated property: definition
annotated target: Germ cell derived tumors resembling parietal or visceral yolk sac endoderm derivatives. Abundant eosinophilic matrix surrounding nests and cords of neoplastic cells. (M-9071-3).
database_cross_reference: Pathbase: Pathology Committee

Axiom
annotated source: endodermal sinus tumor
annotated property: has_related_synonym
annotated target: Yolk sac carcinoma
database_cross_reference: Pathbase: Curation

gonadoblastoma
type: Class
subclass of: germ cell tumor
definition: Gonadal neoplasms that consist of aggregates of germ cells and sex cord elements (M-9073/1).
has_obo_namespace: mouse_pathology.ontology
has_related_synonym: Gonocytoma
id: MPATH:315

Axiom
annotated source: gonadoblastoma
annotated property: definition
annotated target: Gonadal neoplasms that consist of aggregates of germ cells and sex cord elements (M-9073/1).
database_cross_reference: Pathbase: Curation

Axiom
annotated source: gonadoblastoma
annotated property: has_related_synonym
annotated target: Gonocytoma
database_cross_reference: Pathbase: Curation

mixed germ cell tumor
type: Class
subclass of: complex tumor
subclass of: germ cell tumor
definition: Malignant neoplasm of the testis/ovary including various elements of germ cell tumors (M-9085/3).
has_obo_namespace: mouse_pathology.ontology
has_related_synonym: Mixed teratoma and seminoma
id: MPATH:316

Axiom
annotated source: mixed germ cell tumor
annotated property: definition
annotated target: Malignant neoplasm of the testis/ovary including various elements of germ cell tumors (M-9085/3).
database_cross_reference: Pathbase: Curation

Axiom
annotated source: mixed germ cell tumor
annotated property: has_related_synonym
annotated target: Mixed teratoma and seminoma
database_cross_reference: Pathbase: Curation

seminoma
type: Class
subclass of: germ cell tumor
definition: Tumor derived from spermatogenic cells resembling spermatogenia or spermatocytes. NOS ( M9061/3).
has_obo_namespace: mouse_pathology.ontology
has_related_synonym: Germinoma, malignant
has_related_synonym: dysgerminoma
has_related_synonym: spermatoblastoma
has_related_synonym: spermatocytoma, malignant.
id: MPATH:317

Axiom
annotated source: seminoma
annotated property: definition
annotated target: Tumor derived from spermatogenic cells resembling spermatogenia or spermatocytes. NOS ( M9061/3).
database_cross_reference: Pathbase: Curation

Axiom
annotated source: seminoma
annotated property: has_related_synonym
annotated target: Germinoma, malignant
database_cross_reference: Pathbase: Curation

Axiom
annotated source: seminoma
annotated property: has_related_synonym
annotated target: dysgerminoma
database_cross_reference: Pathbase: Curation

Axiom
annotated source: seminoma
annotated property: has_related_synonym
annotated target: spermatoblastoma
database_cross_reference: Pathbase: Curation

Axiom
annotated source: seminoma
annotated property: has_related_synonym
annotated target: spermatocytoma, malignant.
database_cross_reference: Pathbase: Curation

classical seminoma
type: Class
subclass of: seminoma
definition: As MPATH:317, but not spermatocytic (M-9061/3).
has_obo_namespace: mouse_pathology.ontology
id: MPATH:318

Axiom
annotated source: classical seminoma
annotated property: definition
annotated target: As MPATH:317, but not spermatocytic (M-9061/3).
database_cross_reference: Pathbase: Curation

spermatocytic seminoma
type: Class
subclass of: seminoma
definition: Neoplasm of the testis usually found within the tubule. Some debate as to whether it is of germ cell origin in contrast to classical seminoma. Three types of cells are identified in spermatocytic seminomas: those with small, intermediate, and large nuclei in humans. (M-9063/3).
has_obo_namespace: mouse_pathology.ontology
has_related_synonym: Spermatoma
id: MPATH:319

Axiom
annotated source: spermatocytic seminoma
annotated property: definition
annotated target: Neoplasm of the testis usually found within the tubule. Some debate as to whether it is of germ cell origin in contrast to classical seminoma. Three types of cells are identified in spermatocytic seminomas: those with small, intermediate, and large nuclei in humans. (M-9063/3).
database_cross_reference: :Walt; H.; Oosterhuis; J.W. and Stevens; L.C. (1993) Int J Androl; 16; 267-271

Axiom
annotated source: spermatocytic seminoma
annotated property: has_related_synonym
annotated target: Spermatoma
database_cross_reference: Pathbase: Curation

glaucoma
type: Class
subclass of: tissue specific degenerative process
definition: Increase in the intraocular pressure.
has_obo_namespace: mouse_pathology.ontology
id: MPATH:32

Axiom
annotated source: glaucoma
annotated property: definition
annotated target: Increase in the intraocular pressure.
database_cross_reference: Pathbase: Curation

struma ovarii
type: Class
subclass of: germ cell tumor
subclass of: carcinoma
definition: Rare ovarian tumor, regarded as monodermal teratoma, in which thyroid tissue has surpassed the other elements; occasionally associated with hyperthyroidism (M-9090/0).
has_obo_namespace: mouse_pathology.ontology
id: MPATH:320

Axiom
annotated source: struma ovarii
annotated property: definition
annotated target: Rare ovarian tumor, regarded as monodermal teratoma, in which thyroid tissue has surpassed the other elements; occasionally associated with hyperthyroidism (M-9090/0).
database_cross_reference: Pathbase: Curation

teratocarcinoma
type: Class
subclass of: complex tumor
subclass of: germ cell tumor
subclass of: carcinoma
definition: Mixed germ cell neoplasm contaning elements of embryonal carcinoma and teratoma (M-9081/3).
has_obo_namespace: mouse_pathology.ontology
id: MPATH:321

Axiom
annotated source: teratocarcinoma
annotated property: definition
annotated target: Mixed germ cell neoplasm contaning elements of embryonal carcinoma and teratoma (M-9081/3).
database_cross_reference: Pathbase: Curation

teratoma
type: Class
subclass of: complex tumor
subclass of: germ cell tumor
definition: Generally benign germ cell derived tumors of male or female containing derivatives from all three germ layers with differentiation in the malignant form being poor. Malignant tumors are highly metatstatic. (M-9080/1).
has_obo_namespace: mouse_pathology.ontology
id: MPATH:322

Axiom
annotated source: teratoma
annotated property: definition
annotated target: Generally benign germ cell derived tumors of male or female containing derivatives from all three germ layers with differentiation in the malignant form being poor. Malignant tumors are highly metatstatic. (M-9080/1).
database_cross_reference: Pathbase: Pathology Committee

gonadal somatic cell tumor
type: Class
subclass of: gonadal tumor
definition: Neoplasms derived from the non-germ cell derived tissues of the testis and ovary.
has_obo_namespace: mouse_pathology.ontology
id: MPATH:323

Axiom
annotated source: gonadal somatic cell tumor
annotated property: definition
annotated target: Neoplasms derived from the non-germ cell derived tissues of the testis and ovary.
database_cross_reference: Pathbase: Curation

androblastoma
type: Class
definition: obsolete use Sertoli cell tumor MPATH: 331.
has_obo_namespace: mouse_pathology.ontology
id: MPATH:324
deprecated: true

Axiom
annotated source: androblastoma
annotated property: definition
annotated target: obsolete use Sertoli cell tumor MPATH: 331.
database_cross_reference: Pathbase: Curation

fibrothecoma
type: Class
definition: obsolete use thecoma MPATH:334.
has_obo_namespace: mouse_pathology.ontology
id: MPATH:325
deprecated: true

Axiom
annotated source: fibrothecoma
annotated property: definition
annotated target: obsolete use thecoma MPATH:334.
database_cross_reference: Pathbase: Curation

granulosa cell tumor
type: Class
subclass of: gonadal somatic cell tumor
definition: . Derived from sex cord stromal cells. In male thought to be Sertoli cells. (M- 8620/1).
has_obo_namespace: mouse_pathology.ontology
has_related_synonym: Tumor, sex cord stromal, benign, granulosa cell type
has_related_synonym: gynoblastoma (sensu malignant form in ovary)
id: MPATH:326

Axiom
annotated source: granulosa cell tumor
annotated property: definition
annotated target: . Derived from sex cord stromal cells. In male thought to be Sertoli cells. (M- 8620/1).
database_cross_reference: PMID:9789961

Axiom
annotated source: granulosa cell tumor
annotated property: has_related_synonym
annotated target: Tumor, sex cord stromal, benign, granulosa cell type
database_cross_reference: Pathbase: Curation

Axiom
annotated source: granulosa cell tumor
annotated property: has_related_synonym
annotated target: gynoblastoma (sensu malignant form in ovary)
database_cross_reference: Pathbase: Curation

gynandroblastoma
type: Class
definition: gynandroblastoma
has_obo_namespace: mouse_pathology.ontology
id: MPATH:327
comment: obsolete Use sertoli-leydig cell tumor MPATH 332
deprecated: true

Axiom
annotated source: gynandroblastoma
annotated property: definition
annotated target: gynandroblastoma
database_cross_reference: Pathbase: Curation

leydig cell tumor
type: Class
subclass of: gonadal somatic cell tumor
definition: Tumor derived from Leydig cells (M-8650/1).
has_obo_namespace: mouse_pathology.ontology
has_related_synonym: Interstitial cell tumor, benign
has_related_synonym: Leydig cell adenoma
id: MPATH:328

Axiom
annotated source: leydig cell tumor
annotated property: definition
annotated target: Tumor derived from Leydig cells (M-8650/1).
database_cross_reference: Mahler M; Sundberg JP ( 1997) Spontaneous Leydig cell tumors in inbred laboratory mice Lab Animal Science 47:148-52

Axiom
annotated source: leydig cell tumor
annotated property: has_related_synonym
annotated target: Interstitial cell tumor, benign
database_cross_reference: Pathbase: Curation

Axiom
annotated source: leydig cell tumor
annotated property: has_related_synonym
annotated target: Leydig cell adenoma
database_cross_reference: Pathbase: Curation

luteal cell tumor
type: Class
subclass of: gonadal somatic cell tumor
definition: Tumor derived from sex cords composed of highly luteinised cells with extensive pale granular cytoplasm. (M- 8610/0).
has_obo_namespace: mouse_pathology.ontology
has_related_synonym: Luteoma
has_related_synonym: luteinised granulosa cell tumor, benign. Gonadal sex cord stromal tumor, benign, luteoma type
id: MPATH:329

Axiom
annotated source: luteal cell tumor
annotated property: definition
annotated target: Tumor derived from sex cords composed of highly luteinised cells with extensive pale granular cytoplasm. (M- 8610/0).
database_cross_reference: Pathbase: Curation

Axiom
annotated source: luteal cell tumor
annotated property: has_related_synonym
annotated target: Luteoma
database_cross_reference: Pathbase: Curation

Axiom
annotated source: luteal cell tumor
annotated property: has_related_synonym
annotated target: luteinised granulosa cell tumor, benign. Gonadal sex cord stromal tumor, benign, luteoma type
database_cross_reference: Pathbase: Curation

intracellular and extracellular accumulation
type: Class
subclass of: cell and tissue damage
definition: Accumulation of substances within, on the surface of or between cells.
has_obo_namespace: mouse_pathology.ontology
id: MPATH:33

Axiom
annotated source: intracellular and extracellular accumulation
annotated property: definition
annotated target: Accumulation of substances within, on the surface of or between cells.
database_cross_reference: Pathbase: Pathology Committee

ovarian stromal tumor
type: Class
subclass of: complex tumor
subclass of: gonadal somatic cell tumor
definition: Tumor consists of a mixture of granulosa, luteal thecal, Sertoli and stromal cells. (M-8590/1).
has_obo_namespace: mouse_pathology.ontology
id: MPATH:330

Axiom
annotated source: ovarian stromal tumor
annotated property: definition
annotated target: Tumor consists of a mixture of granulosa, luteal thecal, Sertoli and stromal cells. (M-8590/1).
database_cross_reference: Pathbase: Curation

sertoli cell tumor
type: Class
subclass of: gonadal somatic cell tumor
definition: Tumor derived from sex cord/stromal cells; Sertoli cells and can occur in both testis and ovary. (M-8640/1).
has_obo_namespace: mouse_pathology.ontology
has_related_synonym: Androblastoma
has_related_synonym: arrhenoblastoma
has_related_synonym: gonadal stromal tumor
has_related_synonym: sex cord stromal tumor
has_related_synonym: sustentacluar tumor
id: MPATH:331

Axiom
annotated source: sertoli cell tumor
annotated property: definition
annotated target: Tumor derived from sex cord/stromal cells; Sertoli cells and can occur in both testis and ovary. (M-8640/1).
database_cross_reference: Pathbase: Pathology Committee

Axiom
annotated source: sertoli cell tumor
annotated property: has_related_synonym
annotated target: Androblastoma
database_cross_reference: Pathbase: Curation

Axiom
annotated source: sertoli cell tumor
annotated property: has_related_synonym
annotated target: arrhenoblastoma
database_cross_reference: Pathbase: Curation

Axiom
annotated source: sertoli cell tumor
annotated property: has_related_synonym
annotated target: gonadal stromal tumor
database_cross_reference: Pathbase: Curation

Axiom
annotated source: sertoli cell tumor
annotated property: has_related_synonym
annotated target: sex cord stromal tumor
database_cross_reference: Pathbase: Curation

Axiom
annotated source: sertoli cell tumor
annotated property: has_related_synonym
annotated target: sustentacluar tumor
database_cross_reference: Pathbase: Curation

sertoli-leydig cell tumor
type: Class
subclass of: gonadal somatic cell tumor
definition: Tumor of the ovary or testis containing granulosa or theca cell elements with a tubular componant of Sertoli cell type and producing simultaneous androgenic and estrogenic effects. (M-8631/0).
has_obo_namespace: mouse_pathology.ontology
has_related_synonym: Gynandroblastoma
id: MPATH:332

Axiom
annotated source: sertoli-leydig cell tumor
annotated property: definition
annotated target: Tumor of the ovary or testis containing granulosa or theca cell elements with a tubular componant of Sertoli cell type and producing simultaneous androgenic and estrogenic effects. (M-8631/0).
database_cross_reference: Pathbase: Pathology Committee

Axiom
annotated source: sertoli-leydig cell tumor
annotated property: has_related_synonym
annotated target: Gynandroblastoma
database_cross_reference: Pathbase: Curation

sex cord tumor
type: Class
definition: sex cord tumor
has_obo_namespace: mouse_pathology.ontology
id: MPATH:333
comment: obsolete: Use more specific terms: MPATH: 334, 331, 329, 326
deprecated: true

Axiom
annotated source: sex cord tumor
annotated property: definition
annotated target: sex cord tumor
database_cross_reference: Pathbase: Curation

thecoma
type: Class
subclass of: gonadal somatic cell tumor
definition: Derived from sex cord stromal cells, spindle shaped cells arranged in whorls or interlacing bundles. (M- 8600/0).
has_obo_namespace: mouse_pathology.ontology
has_related_synonym: Fibrothecoma
has_related_synonym: theca cell tumor
id: MPATH:334

Axiom
annotated source: thecoma
annotated property: definition
annotated target: Derived from sex cord stromal cells, spindle shaped cells arranged in whorls or interlacing bundles. (M- 8600/0).
database_cross_reference: Pathbase: Curation

Axiom
annotated source: thecoma
annotated property: has_related_synonym
annotated target: Fibrothecoma
database_cross_reference: Pathbase: Curation

Axiom
annotated source: thecoma
annotated property: has_related_synonym
annotated target: theca cell tumor
database_cross_reference: Pathbase: Curation

hematopoietic/lymphoid malignancies/disorder
type: Class
subclass of: neoplasm
definition: Proliferative disorders and malignancies of the lymphoid and non lymphoid haematopoietic lineages.
has_obo_namespace: mouse_pathology.ontology
id: MPATH:335

Axiom
annotated source: hematopoietic/lymphoid malignancies/disorder
annotated property: definition
annotated target: Proliferative disorders and malignancies of the lymphoid and non lymphoid haematopoietic lineages.
database_cross_reference: URL:http://www.bloodjournal.org/cgi/content/full/100/1/238/DC1/2

leukaemia
type: Class
definition: leukaemia
has_obo_namespace: mouse_pathology.ontology
id: MPATH:336
comment: obsolete folowing reclassification.
deprecated: true

Axiom
annotated source: leukaemia
annotated property: definition
annotated target: leukaemia
database_cross_reference: Pathbase: Curation

erythroid leukaemia
type: Class
subclass of: Non-Lymphoid leukaemias
definition: Leukaemia with at least 50% of nucleated erythroid cells infiltrating haematopoietic tissue.
database_cross_reference: URL:http://www.bloodjournal.org/cgi/content/full/100/1/238/DC1/2
has_obo_namespace: mouse_pathology.ontology
id: MPATH:337

Axiom
annotated source: erythroid leukaemia
annotated property: definition
annotated target: Leukaemia with at least 50% of nucleated erythroid cells infiltrating haematopoietic tissue.
database_cross_reference: PMID:12070033

granulocytic leukaemia
type: Class
definition: granulocytic leukaemia
has_obo_namespace: mouse_pathology.ontology
id: MPATH:338
comment: obsolete following reclassification see: MPATH505
deprecated: true

Axiom
annotated source: granulocytic leukaemia
annotated property: definition
annotated target: granulocytic leukaemia
database_cross_reference: Pathbase: Curation

lymphatic leukaemia
type: Class
definition: lymphatic leukaemia
has_obo_namespace: mouse_pathology.ontology
id: MPATH:339
deprecated: true

Axiom
annotated source: lymphatic leukaemia
annotated property: definition
annotated target: lymphatic leukaemia
database_cross_reference: Pathbase: Curation

amyloid deposition
type: Class
subclass of: intracellular and extracellular accumulation
definition: Extracellular deposition of amyloid protein.
has_obo_namespace: mouse_pathology.ontology
has_related_synonym: Amyloidosis
id: MPATH:34
comment: Any group of chemically diverse proteins that appears microscopically homogeneous, but is composed of linear non-branching aggregated fibrils aranged in sheets when see under the electron microscope.

Axiom
annotated source: amyloid deposition
annotated property: definition
annotated target: Extracellular deposition of amyloid protein.
database_cross_reference: ISBN:0781727286

Axiom
annotated source: amyloid deposition
annotated property: has_related_synonym
annotated target: Amyloidosis
database_cross_reference: Pathbase: Curation

megakaryocytic leukaemia
type: Class
subclass of: Non-Lymphoid leukaemias
definition: Leukaemia with at least 50% of megakaryocytic cells infiltrating haematopoietic tissue.
database_cross_reference: URL:http://www.bloodjournal.org/cgi/content/full/100/1/238/DC1/2
has_obo_namespace: mouse_pathology.ontology
id: MPATH:340

Axiom
annotated source: megakaryocytic leukaemia
annotated property: definition
annotated target: Leukaemia with at least 50% of megakaryocytic cells infiltrating haematopoietic tissue.
database_cross_reference: PMID:12070033

myelodysplastic disorder
type: Class
subclass of: myeloid dysplasias
definition: Haematopoietic proliferation with evidence of trilineage dysplasia. Less than 20% should be blasts.
database_cross_reference: URL:http://www.bloodjournal.org/cgi/content/full/100/1/238/DC1/2
has_obo_namespace: mouse_pathology.ontology
id: MPATH:341

Axiom
annotated source: myelodysplastic disorder
annotated property: definition
annotated target: Haematopoietic proliferation with evidence of trilineage dysplasia. Less than 20% should be blasts.
database_cross_reference: PMID:12070033

myeloid leukaemia
type: Class
subclass of: Non-Lymphoid leukaemias
definition: Leukaemias of the myeloid lineage.
database_cross_reference: URL:http://www.bloodjournal.org/cgi/content/full/100/1/238/DC1/2
has_obo_namespace: mouse_pathology.ontology
has_related_synonym: granulocytic leukaemia
id: MPATH:342

Axiom
annotated source: myeloid leukaemia
annotated property: definition
annotated target: Leukaemias of the myeloid lineage.
database_cross_reference: PMID:12070033

Axiom
annotated source: myeloid leukaemia
annotated property: has_related_synonym
annotated target: granulocytic leukaemia
database_cross_reference: Pathbase: Curation

lymphoma
type: Class
definition: lymphoma
has_obo_namespace: mouse_pathology.ontology
id: MPATH:343
comment: obsolete; divided between subtypes of MPATH516, MPATH535
deprecated: true

Axiom
annotated source: lymphoma
annotated property: definition
annotated target: lymphoma
database_cross_reference: Pathbase: Curation

follicle center cell lymphoma
type: Class
definition: follicle center cell lymphoma
has_obo_namespace: mouse_pathology.ontology
id: MPATH:344
comment: obsolete; see MPATH 522
deprecated: true

Axiom
annotated source: follicle center cell lymphoma
annotated property: definition
annotated target: follicle center cell lymphoma
database_cross_reference: Pathbase: Curation

immunoblastic lymphoma
type: Class
definition: immunoblastic lymphoma
has_obo_namespace: mouse_pathology.ontology
id: MPATH:345
comment: obsolete; see MPATH525
deprecated: true

Axiom
annotated source: immunoblastic lymphoma
annotated property: definition
annotated target: immunoblastic lymphoma
database_cross_reference: Pathbase: Curation

autoimmune mediated disease
type: Class
subclass of: immune mediated disease
created by: George Gkoutos
creation date: 2011-03-22T01:12:01Z
has_obo_namespace: mouse_pathology.ontology
id: MPATH:346

small lymphocytic lymphoma
type: Class
definition: small lymphocytic lymphoma
has_obo_namespace: mouse_pathology.ontology
id: MPATH:347
comment: obsolete; see MPATH520
deprecated: true

Axiom
annotated source: small lymphocytic lymphoma
annotated property: definition
annotated target: small lymphocytic lymphoma
database_cross_reference: Pathbase: Curation

thymic lymphoma
type: Class
definition: thymic lymphoma
has_obo_namespace: mouse_pathology.ontology
id: MPATH:348
comment: obsolete
deprecated: true

Axiom
annotated source: thymic lymphoma
annotated property: definition
annotated target: thymic lymphoma
database_cross_reference: Pathbase: Curation

mast cell tumor
type: Class
definition: mast cell tumor
has_obo_namespace: mouse_pathology.ontology
id: MPATH:349
comment: obsolete; see MPATH507
deprecated: true

Axiom
annotated source: mast cell tumor
annotated property: definition
annotated target: mast cell tumor
database_cross_reference: Pathbase: Curation

bile deposition
type: Class
subclass of: pigmentation
definition: Intra- or extracellular deposition of bile pigments and their metabolites.
has_obo_namespace: mouse_pathology.ontology
id: MPATH:35

Axiom
annotated source: bile deposition
annotated property: definition
annotated target: Intra- or extracellular deposition of bile pigments and their metabolites.
database_cross_reference: Pathbase: Pathology Committee

mastocytoma
type: Class
definition: mastocytoma
has_obo_namespace: mouse_pathology.ontology
id: MPATH:350
comment: obsolete. See MPATH507
deprecated: true

Axiom
annotated source: mastocytoma
annotated property: definition
annotated target: mastocytoma
database_cross_reference: Pathbase: Curation

thymoma
type: Class
subclass of: potentially cancerous lesions
definition: A neoplasm in the anterior mediastinum, originating from thymic tissue, usually benign, and frequently encapsulated; occasionally invasive, but metastases are rare; histologically, consists of any type of thymic epithelial cell as well as lymphocytes that are usually abundant. (M-8580/1).
has_obo_namespace: mouse_pathology.ontology
id: MPATH:351

Axiom
annotated source: thymoma
annotated property: definition
annotated target: A neoplasm in the anterior mediastinum, originating from thymic tissue, usually benign, and frequently encapsulated; occasionally invasive, but metastases are rare; histologically, consists of any type of thymic epithelial cell as well as lymphocytes that are usually abundant. (M-8580/1).
database_cross_reference: ISBN:0781727286

hepatic tumor
type: Class
subclass of: neoplasm
definition: Tumors of the liver and biliary apparatus.
has_obo_namespace: mouse_pathology.ontology
id: MPATH:352

Axiom
annotated source: hepatic tumor
annotated property: definition
annotated target: Tumors of the liver and biliary apparatus.
database_cross_reference: Pathbase: Curation

hepatocellular adenoma
type: Class
subclass of: adenoma
subclass of: hepatic tumor
definition: Benign neoplasm derived from hepatocytes. (M- 8170/0).
has_obo_namespace: mouse_pathology.ontology
has_related_synonym: hepatic adenoma, benign, liver cell tumor, benign
has_related_synonym: hepatoma, benign
has_related_synonym: nodule type A
id: MPATH:353

Axiom
annotated source: hepatocellular adenoma
annotated property: definition
annotated target: Benign neoplasm derived from hepatocytes. (M- 8170/0).
database_cross_reference: Pathbase: Curation

Axiom
annotated source: hepatocellular adenoma
annotated property: has_related_synonym
annotated target: hepatic adenoma, benign, liver cell tumor, benign
database_cross_reference: Pathbase: Curation

Axiom
annotated source: hepatocellular adenoma
annotated property: has_related_synonym
annotated target: hepatoma, benign
database_cross_reference: Pathbase: Curation

Axiom
annotated source: hepatocellular adenoma
annotated property: has_related_synonym
annotated target: nodule type A
database_cross_reference: Pathbase: Curation

cholangiocarcinoma
type: Class
subclass of: hepatic tumor
subclass of: carcinoma
definition: Malignant tumor derived from the bile duct epithelium. (M8160/3).
has_obo_namespace: mouse_pathology.ontology
id: MPATH:354

Axiom
annotated source: cholangiocarcinoma
annotated property: definition
annotated target: Malignant tumor derived from the bile duct epithelium. (M8160/3).
database_cross_reference: Pathbase: Pathology Committee

cholangiofibroma
type: Class
subclass of: hepatic tumor
definition: Develops from cholangiofibrosis, fibrosis of the biliary ducts and is only potentially malignant.
has_obo_namespace: mouse_pathology.ontology
id: MPATH:355

Axiom
annotated source: cholangiofibroma
annotated property: definition
annotated target: Develops from cholangiofibrosis, fibrosis of the biliary ducts and is only potentially malignant.
database_cross_reference: Pathbase: Curation

hepatoblastoma
type: Class
subclass of: hepatic tumor
definition: Malignant neoplasm of the liver of unknown origin . Liver blastemal cells, neoplastic hepatocytes, oval cells and biliary epithelial cells have been proposed. (M- 8970/3).
has_obo_namespace: mouse_pathology.ontology
has_related_synonym: embryonal hepatoma
has_related_synonym: tumor, mixed, poorly differentiated
id: MPATH:356

Axiom
annotated source: hepatoblastoma
annotated property: definition
annotated target: Malignant neoplasm of the liver of unknown origin . Liver blastemal cells, neoplastic hepatocytes, oval cells and biliary epithelial cells have been proposed. (M- 8970/3).
database_cross_reference: Pathbase: Curation

Axiom
annotated source: hepatoblastoma
annotated property: has_related_synonym
annotated target: embryonal hepatoma
database_cross_reference: Pathbase: Curation

Axiom
annotated source: hepatoblastoma
annotated property: has_related_synonym
annotated target: tumor, mixed, poorly differentiated
database_cross_reference: Pathbase: Curation

hepatocellular carcinoma
type: Class
subclass of: hepatic tumor
subclass of: carcinoma
definition: Malignant tumor derived from hepatocytes. (M- 8170/3).
has_obo_namespace: mouse_pathology.ontology
has_related_synonym: carcinoma, trabecular
has_related_synonym: carcinoma, trabecular (liver)
has_related_synonym: hepatoma, malignant
has_related_synonym: nodule type B
id: MPATH:357

Axiom
annotated source: hepatocellular carcinoma
annotated property: definition
annotated target: Malignant tumor derived from hepatocytes. (M- 8170/3).
database_cross_reference: Book: Bannasche; P and Zerban; H. Preneoplastic and neoplastic lesions of the rat iver. In; Pathology of neoplasia and preneoplasia in rodents; P. Bannasch and W. Goessner; Editors. 1997. Schattauer; Stuttgart. p. 18-63

Axiom
annotated source: hepatocellular carcinoma
annotated property: has_related_synonym
annotated target: carcinoma, trabecular
database_cross_reference: Pathbase: Curation

Axiom
annotated source: hepatocellular carcinoma
annotated property: has_related_synonym
annotated target: carcinoma, trabecular (liver)
database_cross_reference: Pathbase: Curation

Axiom
annotated source: hepatocellular carcinoma
annotated property: has_related_synonym
annotated target: hepatoma, malignant
database_cross_reference: Pathbase: Curation

Axiom
annotated source: hepatocellular carcinoma
annotated property: has_related_synonym
annotated target: nodule type B
database_cross_reference: Pathbase: Curation

melanocytic tumor
type: Class
subclass of: adnexal and skin appendage tumor
definition: Tumors derived from melanocytes.
has_obo_namespace: mouse_pathology.ontology
id: MPATH:358

Axiom
annotated source: melanocytic tumor
annotated property: definition
annotated target: Tumors derived from melanocytes.
database_cross_reference: Pathbase: Pathology Committee

melanoma
type: Class
subclass of: melanocytic tumor
definition: Tumor of neurectodermal origin, usually melanocytes, showing dense deposition of melanin granules, although amelanotic melanomas have been reported. (M-8720/3).
database_cross_reference: URL: http://emice.nci.nih.gov/emice/mouse_models/organ_models/skin_models/malignant_melanoma#melanoma_table
has_obo_namespace: mouse_pathology.ontology
has_related_synonym: melanosarcoma
has_related_synonym: melanosarcoma, malignant melanoma
id: MPATH:359

Axiom
annotated source: melanoma
annotated property: definition
annotated target: Tumor of neurectodermal origin, usually melanocytes, showing dense deposition of melanin granules, although amelanotic melanomas have been reported. (M-8720/3).
database_cross_reference: Book: Klein-Szanto; A.J.; Neoplastic and preneoplastic lesions of the mouse skin; in Pathology of neoplasia and preneoplasia in rodents; P. Bannasch and W. Goessner; Editors. 1997. Schattauer; Stuttgart. p. 1-18

Axiom
annotated source: melanoma
annotated property: has_related_synonym
annotated target: melanosarcoma
database_cross_reference: Pathbase: Curation

Axiom
annotated source: melanoma
annotated property: has_related_synonym
annotated target: melanosarcoma, malignant melanoma
database_cross_reference: Pathbase: Curation

calcium deposition
type: Class
subclass of: mineralisation
definition: Intra or extracellular deposition of calcium usually as calcium phosphate.
has_obo_namespace: mouse_pathology.ontology
id: MPATH:36

Axiom
annotated source: calcium deposition
annotated property: definition
annotated target: Intra or extracellular deposition of calcium usually as calcium phosphate.
database_cross_reference: Pathbase: Curation

melanoma in situ
type: Class
subclass of: melanocytic tumor
subclass of: potentially cancerous lesions
definition: A potentially malignant lesion, melanoma in situ is the first phase of growth of melanoma, in which it is still confined to the epithelial domain (epidermis and adnexa) and has not passed through the basement membrane. (M-8720/2).
has_obo_namespace: mouse_pathology.ontology
has_related_synonym: level I melanoma
id: MPATH:360

Axiom
annotated source: melanoma in situ
annotated property: definition
annotated target: A potentially malignant lesion, melanoma in situ is the first phase of growth of melanoma, in which it is still confined to the epithelial domain (epidermis and adnexa) and has not passed through the basement membrane. (M-8720/2).
database_cross_reference: Pathbase: Pathology Committee

Axiom
annotated source: melanoma in situ
annotated property: has_related_synonym
annotated target: level I melanoma
database_cross_reference: Pathbase: Curation

naevus
type: Class
subclass of: melanocytic tumor
definition: Local lesion of the skin, often colored by hyperpigmentation or increased vascularity. May be predominantly epidermal, adnexal, melanocytic, vascular, or mesodermal, or a compound overgrowth of these tissues. Not necessarily pre-malignant. (M-8720/0).
has_obo_namespace: mouse_pathology.ontology
has_related_synonym: mole (sensu melanocytic nevus)
id: MPATH:361

Axiom
annotated source: naevus
annotated property: definition
annotated target: Local lesion of the skin, often colored by hyperpigmentation or increased vascularity. May be predominantly epidermal, adnexal, melanocytic, vascular, or mesodermal, or a compound overgrowth of these tissues. Not necessarily pre-malignant. (M-8720/0).
database_cross_reference: Pathbase: Pathology Committee

Axiom
annotated source: naevus
annotated property: has_related_synonym
annotated target: mole (sensu melanocytic nevus)
database_cross_reference: Pathbase: Curation

mesonephroma
type: Class
subclass of: adenocarcinoma
definition: Benign or malignant neoplasm of the ovary and corpus uteri, thought to originate in mesonephric structures. (M-9110/3).
has_obo_namespace: mouse_pathology.ontology
has_related_synonym: mesonephric adenocarcinoma, wolffian duct carcinoma, mesonephroid tumor
id: MPATH:362

Axiom
annotated source: mesonephroma
annotated property: definition
annotated target: Benign or malignant neoplasm of the ovary and corpus uteri, thought to originate in mesonephric structures. (M-9110/3).
database_cross_reference: Pathbase: Pathology Committee

Axiom
annotated source: mesonephroma
annotated property: has_related_synonym
annotated target: mesonephric adenocarcinoma, wolffian duct carcinoma, mesonephroid tumor
database_cross_reference: Pathbase: Curation

mesonephric tumor
type: Class
subclass of: mesonephroma
definition: Tumor beleived to be derived from mesonephric remnants. (M-8310/3).
has_obo_namespace: mouse_pathology.ontology
has_related_synonym: mesonephroid clear cell adenocarcinoma
id: MPATH:363

Axiom
annotated source: mesonephric tumor
annotated property: definition
annotated target: Tumor beleived to be derived from mesonephric remnants. (M-8310/3).
database_cross_reference: Pathbase: Curation

Axiom
annotated source: mesonephric tumor
annotated property: has_related_synonym
annotated target: mesonephroid clear cell adenocarcinoma
database_cross_reference: Pathbase: Curation

mesothelial tumor
type: Class
definition: mesothelial tumor
has_obo_namespace: mouse_pathology.ontology
id: MPATH:364
comment: obsolete; subsumed into MPATH365
deprecated: true

Axiom
annotated source: mesothelial tumor
annotated property: definition
annotated target: mesothelial tumor
database_cross_reference: Pathbase: Curation

mesothelioma
type: Class
subclass of: neoplasm
definition: Benign or malignant neoplasm derived from the lining cells of the pleura and peritoneum, composed of spindle cells or fibrous tissue which may enclose glandlike spaces lined by cuboidal cells. Epithelioid, fibrous, cystis, papillary, and sarcomatoid variants. (M- 9050/3).
has_obo_namespace: mouse_pathology.ontology
id: MPATH:365

Axiom
annotated source: mesothelioma
annotated property: definition
annotated target: Benign or malignant neoplasm derived from the lining cells of the pleura and peritoneum, composed of spindle cells or fibrous tissue which may enclose glandlike spaces lined by cuboidal cells. Epithelioid, fibrous, cystis, papillary, and sarcomatoid variants. (M- 9050/3).
database_cross_reference: Pathbase: Curation

neuroendocrine tumor
type: Class
subclass of: neoplasm
definition: Neoplasms derived from the neuroendocrine system.
has_obo_namespace: mouse_pathology.ontology
id: MPATH:366

Axiom
annotated source: neuroendocrine tumor
annotated property: definition
annotated target: Neoplasms derived from the neuroendocrine system.
database_cross_reference: Pathbase: Curation

carcinoid tumor
type: Class
subclass of: neuroendocrine tumor
definition: Carcinoid tumors are of neuroendocrine origin and derived from primitive stem cells. Found predominantly in the lung and gut they are capable of secreting a large range of substances and have a number of histological subtypes. May resemble but are distinct from small cell lung carcinoma in the lung. (M-8240/3).
has_obo_namespace: mouse_pathology.ontology
id: MPATH:367

Axiom
annotated source: carcinoid tumor
annotated property: definition
annotated target: Carcinoid tumors are of neuroendocrine origin and derived from primitive stem cells. Found predominantly in the lung and gut they are capable of secreting a large range of substances and have a number of histological subtypes. May resemble but are distinct from small cell lung carcinoma in the lung. (M-8240/3).
database_cross_reference: Pathbase: Pathology Committee

endocrine adenocarcinoma
type: Class
definition: obsolete.
has_obo_namespace: mouse_pathology.ontology
id: MPATH:368
deprecated: true

Axiom
annotated source: endocrine adenocarcinoma
annotated property: definition
annotated target: obsolete.
database_cross_reference: Pathbase: Curation

endocrine adenoma
type: Class
definition: endocrine adenoma
has_obo_namespace: mouse_pathology.ontology
id: MPATH:369
deprecated: true

Axiom
annotated source: endocrine adenoma
annotated property: definition
annotated target: endocrine adenoma
database_cross_reference: Pathbase: Curation

ceroid deposition
type: Class
subclass of: pigmentation
definition: Intracellular deposition of golden or yellow-brown pigment, acid fast and insoluble in lipid solvents. Believed to be a type of lipofuscin.
has_obo_namespace: mouse_pathology.ontology
id: MPATH:37

Axiom
annotated source: ceroid deposition
annotated property: definition
annotated target: Intracellular deposition of golden or yellow-brown pigment, acid fast and insoluble in lipid solvents. Believed to be a type of lipofuscin.
database_cross_reference: Pathbase: Pathology Committee

primitive neurectodermal tumor
type: Class
subclass of: CNS progenitor tumor
subclass of: peripheral nervous system tumors
definition: Primitive neuroectodermal tumors (PNET) are neoplasms derived from primitive neural stem cells either in the CNS or the periphery . These are small-cell, malignant embryonal tumors showing divergent differentiation of variable degree along neuronal, glial, or rarely mesenchymal lines. (M-9473/3, M-9364/3).
has_obo_namespace: mouse_pathology.ontology
has_related_synonym: PNET
id: MPATH:370

Axiom
annotated source: primitive neurectodermal tumor
annotated property: definition
annotated target: Primitive neuroectodermal tumors (PNET) are neoplasms derived from primitive neural stem cells either in the CNS or the periphery . These are small-cell, malignant embryonal tumors showing divergent differentiation of variable degree along neuronal, glial, or rarely mesenchymal lines. (M-9473/3, M-9364/3).
database_cross_reference: ISBN-13:9783794515530

Axiom
annotated source: primitive neurectodermal tumor
annotated property: has_related_synonym
annotated target: PNET
database_cross_reference: Pathbase: Curation

small cell carcinoma
type: Class
subclass of: neuroendocrine tumor
subclass of: carcinoma
definition: Neuroendocrine cell derived anaplastic carcinoma composed of small cells, usually of the lung producing a variety of peptide hormones. (M-8041/3). 1.2.3.4 of MMHCC classification.
database_cross_reference: URL: http://emice.nci.nih.gov/mouse_models/organ_models/lung_models/murinecancer/tumorclass
has_obo_namespace: mouse_pathology.ontology
has_related_synonym: oat cell carcinoma
id: MPATH:371
comment: see: Meuwissen, R., Linn, S.C., Linnoila, R.I. et al. (2003) Induction of small cell lung cancer by somatic inactivation of both Trp53 and Rb1 in a conditional mouse model. Cancer cell, 4: 181-189. AND Calbo, J., Meuwissen, R., van Montfort, E. et al. (2005) Genotype-phenotype relationships in a mouse model for human small-cell lung cancer. Cold Spring Harbor symposia on quantitative biology, 70: 225-232. AND Meuwissen, R. and Berns, A. (2005) Mouse models for human lung cancer. Genes & development, 19: 643-664.

Axiom
annotated source: small cell carcinoma
annotated property: definition
annotated target: Neuroendocrine cell derived anaplastic carcinoma composed of small cells, usually of the lung producing a variety of peptide hormones. (M-8041/3). 1.2.3.4 of MMHCC classification.
database_cross_reference: PMID:15059877

Axiom
annotated source: small cell carcinoma
annotated property: has_related_synonym
annotated target: oat cell carcinoma
database_cross_reference: Pathbase: Curation

tumorlet
type: Class
subclass of: neuroendocrine tumor
definition: Small disseminated foci of atypical bronchiolar epithelial hyperplasia. Benign. (M- 8040/1).
has_obo_namespace: mouse_pathology.ontology
id: MPATH:372

Axiom
annotated source: tumorlet
annotated property: definition
annotated target: Small disseminated foci of atypical bronchiolar epithelial hyperplasia. Benign. (M- 8040/1).
database_cross_reference: Pathbase: Pathology Committee

CNS progenitor tumor
type: Class
subclass of: tumors of neurepithelial tissue
definition: Neoplasms derived from neuroepithelial precursors.
has_obo_namespace: mouse_pathology.ontology
id: MPATH:373
comment: Renamed from neuroepitheliomatous tumor, to reflect primitive origins of this class of tumor.

Axiom
annotated source: CNS progenitor tumor
annotated property: definition
annotated target: Neoplasms derived from neuroepithelial precursors.
database_cross_reference: Pathbase: Pathology Committee

esthesioneuroblastoma
type: Class
subclass of: CNS progenitor tumor
definition: A neoplasm of immature, poorly differentiated neuronal cells believed to arise from neuroepithelial precursors in the olfactory epithelium. (M- 9522/3).
has_obo_namespace: mouse_pathology.ontology
has_related_synonym: neuroblastoma, olfactory
has_related_synonym: neuroepithelial carcinoma
has_related_synonym: neuroepithelioma, olfactory
id: MPATH:374

Axiom
annotated source: esthesioneuroblastoma
annotated property: definition
annotated target: A neoplasm of immature, poorly differentiated neuronal cells believed to arise from neuroepithelial precursors in the olfactory epithelium. (M- 9522/3).
database_cross_reference: Pathbase: Curation

Axiom
annotated source: esthesioneuroblastoma
annotated property: has_related_synonym
annotated target: neuroblastoma, olfactory
database_cross_reference: Pathbase: Curation

Axiom
annotated source: esthesioneuroblastoma
annotated property: has_related_synonym
annotated target: neuroepithelial carcinoma
database_cross_reference: Pathbase: Curation

Axiom
annotated source: esthesioneuroblastoma
annotated property: has_related_synonym
annotated target: neuroepithelioma, olfactory
database_cross_reference: Pathbase: Curation

ganglioneuroma
type: Class
subclass of: peripheral nervous system tumors
definition: A benign neoplasm composed of mature ganglionic neurons scattered singly or in clumps within a relatively abundant and dense stroma of neurofibrils and collagenous fibers. (M-9490/0).
has_obo_namespace: mouse_pathology.ontology
id: MPATH:375

Axiom
annotated source: ganglioneuroma
annotated property: definition
annotated target: A benign neoplasm composed of mature ganglionic neurons scattered singly or in clumps within a relatively abundant and dense stroma of neurofibrils and collagenous fibers. (M-9490/0).
database_cross_reference: Pathbase: Pathology Committee

neuroblastoma
type: Class
subclass of: CNS progenitor tumor
definition: A malignant neoplasm characterized by immature, poorly differentiated nerve cells of embryonic type. (M-9500/3).
has_obo_namespace: mouse_pathology.ontology
id: MPATH:376

Axiom
annotated source: neuroblastoma
annotated property: definition
annotated target: A malignant neoplasm characterized by immature, poorly differentiated nerve cells of embryonic type. (M-9500/3).
database_cross_reference: ISBN-13:9783794515530

pheochromocytoma
type: Class
subclass of: neuroendocrine tumor
definition: A catecholamine-secreting tumor arising from the chromaffin cells of the sympathetic nervous system or adrenal medulla. May be benign or malignant. [See MPATH 398]. (M- 8510/3).
has_obo_namespace: mouse_pathology.ontology
id: MPATH:377

Axiom
annotated source: pheochromocytoma
annotated property: definition
annotated target: A catecholamine-secreting tumor arising from the chromaffin cells of the sympathetic nervous system or adrenal medulla. May be benign or malignant. [See MPATH 398]. (M- 8510/3).
database_cross_reference: Pathbase: Pathology Committee

retinoblastoma
type: Class
subclass of: CNS progenitor tumor
definition: Malignant juvenile neoplasm of the eye derived from primitive retinal precursor cells. (M- 9510/3).
has_obo_namespace: mouse_pathology.ontology
id: MPATH:378

Axiom
annotated source: retinoblastoma
annotated property: definition
annotated target: Malignant juvenile neoplasm of the eye derived from primitive retinal precursor cells. (M- 9510/3).
database_cross_reference: Pathbase: Curation

odontogenic tumor
type: Class
subclass of: neoplasm
definition: Neoplasm arising from the tissues of the odontogenic apparatus. These tumors are derived from ectodermal tissue (epithelial tumors) or from mesodermal tissue (connective tissue tumors) or are composed of both components (mixed or composite odontogenic tumors) .
has_obo_namespace: mouse_pathology.ontology
id: MPATH:379

Axiom
annotated source: odontogenic tumor
annotated property: definition
annotated target: Neoplasm arising from the tissues of the odontogenic apparatus. These tumors are derived from ectodermal tissue (epithelial tumors) or from mesodermal tissue (connective tissue tumors) or are composed of both components (mixed or composite odontogenic tumors) .
database_cross_reference: Pathbase: Pathology Committee

copper deposition
type: Class
subclass of: protein deposition
subclass of: mineralisation
definition: Intra and extracellular deposition of copper and copper containing proteins.
has_obo_namespace: mouse_pathology.ontology
id: MPATH:38

Axiom
annotated source: copper deposition
annotated property: definition
annotated target: Intra and extracellular deposition of copper and copper containing proteins.
database_cross_reference: Pathbase: Curation

ameloblastic fibroma
type: Class
subclass of: odontogenic tumor
definition: A tumor consisting of proliferating strands and clumps of odontogenic epithelium in a highly cellular fibroblastic stroma resembling the dental papilla of developing teeth. The epithelial component are composed of peripheral cuboidal or cylindrical cells enclosing scant stellate cells. (M-9330/0).
has_obo_namespace: mouse_pathology.ontology
id: MPATH:380

Axiom
annotated source: ameloblastic fibroma
annotated property: definition
annotated target: A tumor consisting of proliferating strands and clumps of odontogenic epithelium in a highly cellular fibroblastic stroma resembling the dental papilla of developing teeth. The epithelial component are composed of peripheral cuboidal or cylindrical cells enclosing scant stellate cells. (M-9330/0).
database_cross_reference: Pathbase: Pathology Committee

ameloblastoma
type: Class
subclass of: odontogenic tumor
definition: Benign odontogenic epithelial neoplasm that histologically mimics the embryonic enamel organ but does not differentiate to the point of forming dental hard tissue. Histologically dominated by epithelial cells in a scant fibroblastic stroma. (M-9310/0).
has_obo_namespace: mouse_pathology.ontology
id: MPATH:381

Axiom
annotated source: ameloblastoma
annotated property: definition
annotated target: Benign odontogenic epithelial neoplasm that histologically mimics the embryonic enamel organ but does not differentiate to the point of forming dental hard tissue. Histologically dominated by epithelial cells in a scant fibroblastic stroma. (M-9310/0).
database_cross_reference: Pathbase: Pathology Committee

cementifying fibroma
type: Class
subclass of: odontogenic tumor
definition: Benign neoplasm derived from pluripotential mesenchymal cells or cementoblasts. Well demarcated tumor occurring exclusively in the jaw containing spindle cells which undergo transformation to cuboidal cementoblasts forming multiple cementicle like bodies. ( M-9274/0).
has_obo_namespace: mouse_pathology.ontology
has_related_synonym: ossifying fibroma, cemento-ossifying fibroma
id: MPATH:382

Axiom
annotated source: cementifying fibroma
annotated property: definition
annotated target: Benign neoplasm derived from pluripotential mesenchymal cells or cementoblasts. Well demarcated tumor occurring exclusively in the jaw containing spindle cells which undergo transformation to cuboidal cementoblasts forming multiple cementicle like bodies. ( M-9274/0).
database_cross_reference: Pathbase: Curation

Axiom
annotated source: cementifying fibroma
annotated property: has_related_synonym
annotated target: ossifying fibroma, cemento-ossifying fibroma
database_cross_reference: Pathbase: Curation

cementoblastoma
type: Class
subclass of: odontogenic tumor
definition: A neoplasm arising from the periodontal ligament (M-9273/0).
has_obo_namespace: mouse_pathology.ontology
has_related_synonym: True cementoma
id: MPATH:383

Axiom
annotated source: cementoblastoma
annotated property: definition
annotated target: A neoplasm arising from the periodontal ligament (M-9273/0).
database_cross_reference: Pathbase: Curation

Axiom
annotated source: cementoblastoma
annotated property: has_related_synonym
annotated target: True cementoma
database_cross_reference: Pathbase: Curation

cementoma
type: Class
subclass of: odontogenic tumor
definition: Reactive fibro-osseous lesion derived from odotongenic cells in the periodontal ligament (M-9272/0).
has_obo_namespace: mouse_pathology.ontology
id: MPATH:384

Axiom
annotated source: cementoma
annotated property: definition
annotated target: Reactive fibro-osseous lesion derived from odotongenic cells in the periodontal ligament (M-9272/0).
database_cross_reference: Pathbase: Curation

dentinoma
type: Class
subclass of: odontogenic tumor
definition: Similar lesion to ameloblastic fibroma (MPATH380) , but also showing inductive changes that lead to the formation of dentine (M-9271/0).
has_obo_namespace: mouse_pathology.ontology
has_related_synonym: ameloblastic fibrodentinoma
id: MPATH:385

Axiom
annotated source: dentinoma
annotated property: definition
annotated target: Similar lesion to ameloblastic fibroma (MPATH380) , but also showing inductive changes that lead to the formation of dentine (M-9271/0).
database_cross_reference: Pathbase: Curation

Axiom
annotated source: dentinoma
annotated property: has_related_synonym
annotated target: ameloblastic fibrodentinoma
database_cross_reference: Pathbase: Curation

odontogenic tumor
type: Class
definition: odontogenic tumor
has_obo_namespace: mouse_pathology.ontology
id: MPATH:386
comment: redundant
deprecated: true

Axiom
annotated source: odontogenic tumor
annotated property: definition
annotated target: odontogenic tumor
database_cross_reference: Pathbase: Curation

odontoma
type: Class
subclass of: complex tumor
subclass of: odontogenic tumor
subclass of: hamartoma
definition: Hamartomatous malformation of odontogenic tissue. It may vary from nondescript masses of dental tissue (complex odontoma) to multiple well-formed teeth (compound odontoma). Cf ameloblastic fibro-odontoma. (M-9280/0).
has_obo_namespace: mouse_pathology.ontology
id: MPATH:387

Axiom
annotated source: odontoma
annotated property: definition
annotated target: Hamartomatous malformation of odontogenic tissue. It may vary from nondescript masses of dental tissue (complex odontoma) to multiple well-formed teeth (compound odontoma). Cf ameloblastic fibro-odontoma. (M-9280/0).
database_cross_reference: ISBN:0781727286

osseous and chondromatous tumor
type: Class
subclass of: neoplasm
definition: Neoplasms of bone and cartilage.
has_obo_namespace: mouse_pathology.ontology
id: MPATH:388

Axiom
annotated source: osseous and chondromatous tumor
annotated property: definition
annotated target: Neoplasms of bone and cartilage.
database_cross_reference: Pathbase: Curation

chondroblastoma
type: Class
subclass of: osseous and chondromatous tumor
definition: A benign or malignant neoplasm occuring in the epiphyses of long bones, consisting of highly cellular tissue resembling embryonic cartilage. (M-9230/0, /3).
has_obo_namespace: mouse_pathology.ontology
id: MPATH:389

Axiom
annotated source: chondroblastoma
annotated property: definition
annotated target: A benign or malignant neoplasm occuring in the epiphyses of long bones, consisting of highly cellular tissue resembling embryonic cartilage. (M-9230/0, /3).
database_cross_reference: Pathbase: Pathology Committee

glycogen deposition
type: Class
subclass of: intracellular and extracellular accumulation
definition: Intracellular deposition of glycogen.
has_obo_namespace: mouse_pathology.ontology
id: MPATH:39

Axiom
annotated source: glycogen deposition
annotated property: definition
annotated target: Intracellular deposition of glycogen.
database_cross_reference: Pathbase: Curation

chondroblastoma, malignant
type: Class
definition: chondroblastoma, malignant
has_obo_namespace: mouse_pathology.ontology
id: MPATH:390
comment: Subsumed into MPATH:389
deprecated: true

Axiom
annotated source: chondroblastoma, malignant
annotated property: definition
annotated target: chondroblastoma, malignant
database_cross_reference: Pathbase: Curation

chondroma
type: Class
subclass of: osseous and chondromatous tumor
definition: A benign neoplasm derived from mesodermal cells that form cartilage composed of well differentiated hyaline cartilage (M-9220/0).
has_obo_namespace: mouse_pathology.ontology
id: MPATH:391

Axiom
annotated source: chondroma
annotated property: definition
annotated target: A benign neoplasm derived from mesodermal cells that form cartilage composed of well differentiated hyaline cartilage (M-9220/0).
database_cross_reference: Pathbase: Curation

chondrosarcoma
type: Class
subclass of: osseous and chondromatous tumor
definition: Malignant neoplasm derived form pluripotential mesenchymal cells, chondrocytes or chondroblasts. No production of osteoid. (M-9220/3).
has_obo_namespace: mouse_pathology.ontology
id: MPATH:392

Axiom
annotated source: chondrosarcoma
annotated property: definition
annotated target: Malignant neoplasm derived form pluripotential mesenchymal cells, chondrocytes or chondroblasts. No production of osteoid. (M-9220/3).
database_cross_reference: Pathbase: Pathology Committee

osteoblastoma
type: Class
subclass of: osseous and chondromatous tumor
definition: Generally benign osteogenic neoplasm of unknown aetiology. Aggressive form may be confused with osteosarcoma. NOT a syn for osteofibroma. (M-9200/0).
has_obo_namespace: mouse_pathology.ontology
has_related_synonym: giant osteoid osteoma, benign osteoblastoma
id: MPATH:393

Axiom
annotated source: osteoblastoma
annotated property: definition
annotated target: Generally benign osteogenic neoplasm of unknown aetiology. Aggressive form may be confused with osteosarcoma. NOT a syn for osteofibroma. (M-9200/0).
database_cross_reference: Pathbase: Pathology Committee

Axiom
annotated source: osteoblastoma
annotated property: has_related_synonym
annotated target: giant osteoid osteoma, benign osteoblastoma
database_cross_reference: Pathbase: Curation

osteochondroma
type: Class
subclass of: osseous and chondromatous tumor
definition: Benign bone tumor characterized by hyaline cartilage capped bony growths that project from the surface of the affected bone. (M-9210/0).
has_obo_namespace: mouse_pathology.ontology
has_related_synonym: cartilaginous exostosis
id: MPATH:394

Axiom
annotated source: osteochondroma
annotated property: definition
annotated target: Benign bone tumor characterized by hyaline cartilage capped bony growths that project from the surface of the affected bone. (M-9210/0).
database_cross_reference: Pathbase: Pathology Committee

Axiom
annotated source: osteochondroma
annotated property: has_related_synonym
annotated target: cartilaginous exostosis
database_cross_reference: Pathbase: Curation

osteofibroma
type: Class
subclass of: osseous and chondromatous tumor
definition: Benign neoplasm derived from pluripotential mesenchymal stem cells or osteoblasts composed of mature nbone trabelculae seperated by a stroma of spindle cells. (M- 9262/0).
has_obo_namespace: mouse_pathology.ontology
id: MPATH:395

Axiom
annotated source: osteofibroma
annotated property: definition
annotated target: Benign neoplasm derived from pluripotential mesenchymal stem cells or osteoblasts composed of mature nbone trabelculae seperated by a stroma of spindle cells. (M- 9262/0).
database_cross_reference: Pathbase: Curation

osteoma
type: Class
subclass of: osseous and chondromatous tumor
definition: Benign neoplasm derived from osteoblasts or osteocytes composed of very dense bone with predominantly woven structure. ( M-9180/0).
has_obo_namespace: mouse_pathology.ontology
has_related_synonym: cancellous osteoma
has_related_synonym: compact osteoma
has_related_synonym: juxtacortical osteoma
has_related_synonym: medullary osteoma
has_related_synonym: osteoid osteoma
has_related_synonym: spongious osteoma
has_related_synonym: trabecular osteoma
id: MPATH:396

Axiom
annotated source: osteoma
annotated property: definition
annotated target: Benign neoplasm derived from osteoblasts or osteocytes composed of very dense bone with predominantly woven structure. ( M-9180/0).
database_cross_reference: Book: Luz; A and Gessner; W. ; Neoplastic bone lesions of the mouse; in Pathology of neoplasia and preneoplasia in rodents; P. Bannasch and W. Goessner; Editors. 1997. Schattauer; Stuttgart. p. 142-154

Axiom
annotated source: osteoma
annotated property: has_related_synonym
annotated target: cancellous osteoma
database_cross_reference: Pathbase: Curation

Axiom
annotated source: osteoma
annotated property: has_related_synonym
annotated target: compact osteoma
database_cross_reference: Pathbase: Curation

Axiom
annotated source: osteoma
annotated property: has_related_synonym
annotated target: juxtacortical osteoma
database_cross_reference: Pathbase: Curation

Axiom
annotated source: osteoma
annotated property: has_related_synonym
annotated target: medullary osteoma
database_cross_reference: Pathbase: Curation

Axiom
annotated source: osteoma
annotated property: has_related_synonym
annotated target: osteoid osteoma
database_cross_reference: Pathbase: Curation

Axiom
annotated source: osteoma
annotated property: has_related_synonym
annotated target: spongious osteoma
database_cross_reference: Pathbase: Curation

Axiom
annotated source: osteoma
annotated property: has_related_synonym
annotated target: trabecular osteoma
database_cross_reference: Pathbase: Curation

osteosarcoma
type: Class
subclass of: osseous and chondromatous tumor
definition: Malignant neoplasm derived form mesenchymal stem cells, osteoblasts or osteocytes. Highly invasive and destructive tumor rising in the skeleton with osteoid and immature woven bone. (M-9180/3).
has_obo_namespace: mouse_pathology.ontology
has_related_synonym: osteogenic sarcoma
id: MPATH:397

Axiom
annotated source: osteosarcoma
annotated property: definition
annotated target: Malignant neoplasm derived form mesenchymal stem cells, osteoblasts or osteocytes. Highly invasive and destructive tumor rising in the skeleton with osteoid and immature woven bone. (M-9180/3).
database_cross_reference: Pathbase: Curation

Axiom
annotated source: osteosarcoma
annotated property: has_related_synonym
annotated target: osteogenic sarcoma
database_cross_reference: Pathbase: Curation

paragangliomas and glomus tumor
type: Class
subclass of: neuroendocrine tumor
definition: Generally benign neoplasms of CHIEF cells arising from neuroectodermal tissues, found in various parts of the body. Note that until recently, glomus tumors were believed to be derived from specialised vascular cells, which is incorrect. Paraganglioma is the preferred term.The nomenclature for pheochromocytoma and paraganglioma is inconsistent. The term paraganglioma is used to refer to any extra-adrenal tumor of the paraganglion system or nonfunctional tumor of the paraganglion system. Functional tumors are referred extra-adrenal pheochromocytoma.
has_obo_namespace: mouse_pathology.ontology
id: MPATH:398

Axiom
annotated source: paragangliomas and glomus tumor
annotated property: definition
annotated target: Generally benign neoplasms of CHIEF cells arising from neuroectodermal tissues, found in various parts of the body. Note that until recently, glomus tumors were believed to be derived from specialised vascular cells, which is incorrect. Paraganglioma is the preferred term.The nomenclature for pheochromocytoma and paraganglioma is inconsistent. The term paraganglioma is used to refer to any extra-adrenal tumor of the paraganglion system or nonfunctional tumor of the paraganglion system. Functional tumors are referred extra-adrenal pheochromocytoma.
database_cross_reference: Pathbase: Curation

aortic body tumor
type: Class
subclass of: paragangliomas and glomus tumor
definition: Paraganglioma arising in the CHIEF cells of the aortic body (M-8691/1).
has_obo_namespace: mouse_pathology.ontology
has_related_synonym: aortic body paraganglioma
id: MPATH:399

Axiom
annotated source: aortic body tumor
annotated property: definition
annotated target: Paraganglioma arising in the CHIEF cells of the aortic body (M-8691/1).
database_cross_reference: Pathbase: Curation

Axiom
annotated source: aortic body tumor
annotated property: has_related_synonym
annotated target: aortic body paraganglioma
database_cross_reference: Pathbase: Curation

necrosis
type: Class
subclass of: cell death
definition: Morpholological changes after intravital (Pathologic) death of one or more cells, or of a portion of tissue or organ, resulting from irreversible damage;characterised by mitochondrial swelling, nuclear pyknosis, karyolysis, swollen and abnormally pale basophilic staining; or karyorrhexis, rupture and fragmentation of the nucleus. Energy independent cf. Apoptosis MPATH 3.
has_obo_namespace: mouse_pathology.ontology
id: MPATH:4

Axiom
annotated source: necrosis
annotated property: definition
annotated target: Morpholological changes after intravital (Pathologic) death of one or more cells, or of a portion of tissue or organ, resulting from irreversible damage;characterised by mitochondrial swelling, nuclear pyknosis, karyolysis, swollen and abnormally pale basophilic staining; or karyorrhexis, rupture and fragmentation of the nucleus. Energy independent cf. Apoptosis MPATH 3.
database_cross_reference: ISBN:0781727286

hyalinosis
type: Class
subclass of: intracellular and extracellular accumulation
definition: Intracellular deposition of eosinophilic material.
has_obo_namespace: mouse_pathology.ontology
has_related_synonym: Hyaline degeneration, Eosinophilic cytoplasmic change
id: MPATH:40

Axiom
annotated source: hyalinosis
annotated property: definition
annotated target: Intracellular deposition of eosinophilic material.
database_cross_reference: PMID: 11794381

Axiom
annotated source: hyalinosis
annotated property: has_related_synonym
annotated target: Hyaline degeneration, Eosinophilic cytoplasmic change
database_cross_reference: Pathbase: Curation

carotid body tumor
type: Class
subclass of: paragangliomas and glomus tumor
definition: Paraganglioma arising in the CHIEF cells of the carotid body (M-8692/1).
has_obo_namespace: mouse_pathology.ontology
has_related_synonym: carotid body paraganglioma
id: MPATH:400

Axiom
annotated source: carotid body tumor
annotated property: definition
annotated target: Paraganglioma arising in the CHIEF cells of the carotid body (M-8692/1).
database_cross_reference: Pathbase: Pathology Committee

Axiom
annotated source: carotid body tumor
annotated property: has_related_synonym
annotated target: carotid body paraganglioma
database_cross_reference: Pathbase: Curation

glomus jugulare tumor
type: Class
subclass of: paragangliomas and glomus tumor
definition: A glomus tumor arising from the chief cells of the paraganglia ( neurectodermal derivatives) , or glomus bodies, located within the wall (adventitia) of the jugular bulb. (8690/1).
has_obo_namespace: mouse_pathology.ontology
id: MPATH:401

Axiom
annotated source: glomus jugulare tumor
annotated property: definition
annotated target: A glomus tumor arising from the chief cells of the paraganglia ( neurectodermal derivatives) , or glomus bodies, located within the wall (adventitia) of the jugular bulb. (8690/1).
database_cross_reference: Pathbase: Curation

glomus tumor
type: Class
definition: glomus tumor
has_obo_namespace: mouse_pathology.ontology
id: MPATH:402
comment: obsolete; use paraganglioma M-8711/0) or specific example terms, MPATH399-401.
deprecated: true

Axiom
annotated source: glomus tumor
annotated property: definition
annotated target: glomus tumor
database_cross_reference: Pathbase: Curation

paraganglioma
type: Class
subclass of: paragangliomas and glomus tumor
definition: A neoplasm composed of derivatives of CHIEF cells usually in single encapsulated nodular masses surrounded with sustentacular cells. ( M- 8711/0).
has_obo_namespace: mouse_pathology.ontology
has_related_synonym: chemodectomas
has_related_synonym: glomus tumor
has_related_synonym: non-chromaffin paragangliomas
id: MPATH:403

Axiom
annotated source: paraganglioma
annotated property: definition
annotated target: A neoplasm composed of derivatives of CHIEF cells usually in single encapsulated nodular masses surrounded with sustentacular cells. ( M- 8711/0).
database_cross_reference: Pathbase: Curation

Axiom
annotated source: paraganglioma
annotated property: has_related_synonym
annotated target: chemodectomas
database_cross_reference: Pathbase: Curation

Axiom
annotated source: paraganglioma
annotated property: has_related_synonym
annotated target: glomus tumor
database_cross_reference: Pathbase: Curation

Axiom
annotated source: paraganglioma
annotated property: has_related_synonym
annotated target: non-chromaffin paragangliomas
database_cross_reference: Pathbase: Curation

soft tissue tumor
type: Class
subclass of: neoplasm
definition: Neoplasms of the soft and connective tissues.
has_obo_namespace: mouse_pathology.ontology
id: MPATH:404

Axiom
annotated source: soft tissue tumor
annotated property: definition
annotated target: Neoplasms of the soft and connective tissues.
database_cross_reference: Pathbase: Curation

chordoma
type: Class
subclass of: soft tissue tumor
definition: Believed to arise from primitive notochord remnants . Usually occurs along the axial skeleton and is characterised by the presence of bubble cells containing large unstained cytoplasmic vacuoles with central or eccentricc nuclei. Benign but locally invasive. (M-9370/3).
has_obo_namespace: mouse_pathology.ontology
id: MPATH:405

Axiom
annotated source: chordoma
annotated property: definition
annotated target: Believed to arise from primitive notochord remnants . Usually occurs along the axial skeleton and is characterised by the presence of bubble cells containing large unstained cytoplasmic vacuoles with central or eccentricc nuclei. Benign but locally invasive. (M-9370/3).
database_cross_reference: Pathbase: Curation

dermatofibrosarcoma
type: Class
subclass of: soft tissue tumor
subclass of: sarcoma
definition: Highly recurrent, infiltrative skin tumors of intermediate malignancy derived from fibroblasts/fibrocytes. Human condition dermatofibrosarcoma protruberans (M-8832/3).
has_obo_namespace: mouse_pathology.ontology
id: MPATH:406

Axiom
annotated source: dermatofibrosarcoma
annotated property: definition
annotated target: Highly recurrent, infiltrative skin tumors of intermediate malignancy derived from fibroblasts/fibrocytes. Human condition dermatofibrosarcoma protruberans (M-8832/3).
database_cross_reference: Pathbase: Curation

fibroma
type: Class
subclass of: soft tissue tumor
subclass of: sarcoma
definition: Benign neoplasm of fibroblasts/fibrocytes with poor/moderate cellularity. (M-8810/0).
has_obo_namespace: mouse_pathology.ontology
id: MPATH:407
comment: "Soft tissue" qualifier removed by Pathology Panel to increase scope of term.

Axiom
annotated source: fibroma
annotated property: definition
annotated target: Benign neoplasm of fibroblasts/fibrocytes with poor/moderate cellularity. (M-8810/0).
database_cross_reference: Pathbase: Pathology Committee

soft tissue fibrosarcoma
type: Class
subclass of: soft tissue tumor
subclass of: sarcoma
definition: Malignant tumor derived from pluripotential mesenchymal stem cells; fibroblasts, fibrocytes (M-8810/3).
has_exact_synonym: fibrosarcoma
has_obo_namespace: mouse_pathology.ontology
id: MPATH:408

Axiom
annotated source: soft tissue fibrosarcoma
annotated property: definition
annotated target: Malignant tumor derived from pluripotential mesenchymal stem cells; fibroblasts, fibrocytes (M-8810/3).
database_cross_reference: Pathbase: Pathology Committee

fibrous histiocytoma
type: Class
subclass of: soft tissue tumor
definition: Benign or maligant tumor derived from pluripotential mesenchymal stem cells showing fibrous and histiocytic differentiation (M-8830/0).
has_obo_namespace: mouse_pathology.ontology
id: MPATH:409

Axiom
annotated source: fibrous histiocytoma
annotated property: definition
annotated target: Benign or maligant tumor derived from pluripotential mesenchymal stem cells showing fibrous and histiocytic differentiation (M-8830/0).
database_cross_reference: Pathbase: Curation

iron deposition
type: Class
subclass of: protein deposition
subclass of: mineralisation
definition: Extra- or intra-cellular deposition of iron, iron containing proteins or hemosiderin.
has_obo_namespace: mouse_pathology.ontology
id: MPATH:41

Axiom
annotated source: iron deposition
annotated property: definition
annotated target: Extra- or intra-cellular deposition of iron, iron containing proteins or hemosiderin.
database_cross_reference: Pathbase: Curation

giant cell tumor of soft tissue
type: Class
subclass of: soft tissue tumor
definition: Malignant or benign tumor of pluripotential mesenchymal stem cells giving rise to large multinucleated cells (M- 9251/1).
has_obo_namespace: mouse_pathology.ontology
has_related_synonym: giant cell fibrous histiocytoma
id: MPATH:410

Axiom
annotated source: giant cell tumor of soft tissue
annotated property: definition
annotated target: Malignant or benign tumor of pluripotential mesenchymal stem cells giving rise to large multinucleated cells (M- 9251/1).
database_cross_reference: Pathbase: Pathology Committee

Axiom
annotated source: giant cell tumor of soft tissue
annotated property: has_related_synonym
annotated target: giant cell fibrous histiocytoma
database_cross_reference: Pathbase: Curation

granular cell tumor/alveolar sarcoma
type: Class
definition: granular cell tumor/alveolar sarcoma
has_obo_namespace: mouse_pathology.ontology
id: MPATH:411
comment: obsolete. Use specific terms MPATH: 412 or MPATH: 413
deprecated: true

Axiom
annotated source: granular cell tumor/alveolar sarcoma
annotated property: definition
annotated target: granular cell tumor/alveolar sarcoma
database_cross_reference: Pathbase: Curation

alveolar soft part sarcoma
type: Class
subclass of: soft tissue tumor
subclass of: sarcoma
definition: Malignant tumor of unknown origin though probably myogenic due to expression of MyoD and other myogenic lineage markers. Consists of grouped polygonal tumor cells with granular eosinophilic cytoplasm arranged in an organ-like configuration separated by thin fibrovascular septa. Central areas within these nests of cells become necrotic, and the loss of architecture produces an alveolar appearance. (M-9581/3).
has_obo_namespace: mouse_pathology.ontology
id: MPATH:412

Axiom
annotated source: alveolar soft part sarcoma
annotated property: definition
annotated target: Malignant tumor of unknown origin though probably myogenic due to expression of MyoD and other myogenic lineage markers. Consists of grouped polygonal tumor cells with granular eosinophilic cytoplasm arranged in an organ-like configuration separated by thin fibrovascular septa. Central areas within these nests of cells become necrotic, and the loss of architecture produces an alveolar appearance. (M-9581/3).
database_cross_reference: Pathbase: Pathology Committee

granular cell tumor
type: Class
subclass of: myomatous tumor
definition: Large polygonal or round cell tumors with abundant acidophilic cytoplasm containing PAS positive granules. Found especially in the uterine cervix. Aetiology unknown. (M-9580/0).
has_obo_namespace: mouse_pathology.ontology
has_related_synonym: myoblastoma
id: MPATH:413

Axiom
annotated source: granular cell tumor
annotated property: definition
annotated target: Large polygonal or round cell tumors with abundant acidophilic cytoplasm containing PAS positive granules. Found especially in the uterine cervix. Aetiology unknown. (M-9580/0).
database_cross_reference: Pathbase: Pathology Committee

Axiom
annotated source: granular cell tumor
annotated property: has_related_synonym
annotated target: myoblastoma
database_cross_reference: Pathbase: Curation

histiocytic sarcoma
type: Class
definition: histiocytic sarcoma
has_obo_namespace: mouse_pathology.ontology
id: MPATH:414
comment: redundant use MPATH506
deprecated: true

Axiom
annotated source: histiocytic sarcoma
annotated property: definition
annotated target: histiocytic sarcoma
database_cross_reference: Pathbase: Curation

lipomatous tumor
type: Class
subclass of: soft tissue tumor
definition: Tumors derived from the lipogenic lineage or showing predominantly lipomatous differentiation.
has_obo_namespace: mouse_pathology.ontology
id: MPATH:415

Axiom
annotated source: lipomatous tumor
annotated property: definition
annotated target: Tumors derived from the lipogenic lineage or showing predominantly lipomatous differentiation.
database_cross_reference: Pathbase: Curation

angiomyolipoma
type: Class
subclass of: complex tumor
subclass of: lipomatous tumor
definition: Benign renal neoplasm composed of fat, vascular, and smooth muscle elements. Associated with tuberous sclerosis in humans. Aetiology unknown, but the combination of elements may reflect a lesion specific pattern of metaplasia. (M-8860/0).
has_obo_namespace: mouse_pathology.ontology
id: MPATH:416

Axiom
annotated source: angiomyolipoma
annotated property: definition
annotated target: Benign renal neoplasm composed of fat, vascular, and smooth muscle elements. Associated with tuberous sclerosis in humans. Aetiology unknown, but the combination of elements may reflect a lesion specific pattern of metaplasia. (M-8860/0).
database_cross_reference: Pathbase: Pathology Committee

lipoma
type: Class
subclass of: lipomatous tumor
definition: Benign neoplasia derived from lipoblasts or lipocytes of white or brown fat. May be angiomatous or hibernomatous. (M- 8850/0).
has_obo_namespace: mouse_pathology.ontology
id: MPATH:417

Axiom
annotated source: lipoma
annotated property: definition
annotated target: Benign neoplasia derived from lipoblasts or lipocytes of white or brown fat. May be angiomatous or hibernomatous. (M- 8850/0).
database_cross_reference: Pathbase: Pathology Committee

liposarcoma
type: Class
subclass of: lipomatous tumor
subclass of: sarcoma
definition: Malignant neoplasms which probably originate in primitive mesenchymal stem cell populations differentiating down a lipomatous pathway. (M-8850/3).
has_obo_namespace: mouse_pathology.ontology
id: MPATH:418

Axiom
annotated source: liposarcoma
annotated property: definition
annotated target: Malignant neoplasms which probably originate in primitive mesenchymal stem cell populations differentiating down a lipomatous pathway. (M-8850/3).
database_cross_reference: Pathbase: Pathology Committee

lymphatic vessel tumor
type: Class
subclass of: soft tissue tumor
definition: Neoplasms of the lymphatic vessels.
has_obo_namespace: mouse_pathology.ontology
id: MPATH:419

Axiom
annotated source: lymphatic vessel tumor
annotated property: definition
annotated target: Neoplasms of the lymphatic vessels.
database_cross_reference: Pathbase: Curation

lipid deposition
type: Class
subclass of: intracellular and extracellular accumulation
definition: Extra or intracellular deposition of lipid.
has_obo_namespace: mouse_pathology.ontology
id: MPATH:42

Axiom
annotated source: lipid deposition
annotated property: definition
annotated target: Extra or intracellular deposition of lipid.
database_cross_reference: Pathbase: Curation

lymphangioma
type: Class
subclass of: lymphatic vessel tumor
subclass of: hamartoma
definition: Benign hamartomatous malformation of the lymphatic ducts. Usually found in the skin and may be superficial or deep. (M-9170/0).
has_broad_synonym: Hygroma
has_obo_namespace: mouse_pathology.ontology
id: MPATH:420

Axiom
annotated source: lymphangioma
annotated property: definition
annotated target: Benign hamartomatous malformation of the lymphatic ducts. Usually found in the skin and may be superficial or deep. (M-9170/0).
database_cross_reference: ISBN:0781727286

Axiom
annotated source: lymphangioma
annotated property: has_broad_synonym
annotated target: Hygroma
database_cross_reference: ISBN:0-19-261976-4

lymphangiomyomatosis
type: Class
subclass of: lymphatic vessel tumor
definition: Characterized by benign peribronchial, perivascular, and perilymphatic proliferation of atypical smooth muscle resulting in vascular and airway obstruction, cyst formation, and a progressive decline in lung function. (M- 9174/1).
has_obo_namespace: mouse_pathology.ontology
has_related_synonym: Lymphangioleiomyomatosis.
id: MPATH:421

Axiom
annotated source: lymphangiomyomatosis
annotated property: definition
annotated target: Characterized by benign peribronchial, perivascular, and perilymphatic proliferation of atypical smooth muscle resulting in vascular and airway obstruction, cyst formation, and a progressive decline in lung function. (M- 9174/1).
database_cross_reference: Pathbase: Curation

Axiom
annotated source: lymphangiomyomatosis
annotated property: has_related_synonym
annotated target: Lymphangioleiomyomatosis.
database_cross_reference: Pathbase: Curation

lymphangiosarcoma
type: Class
subclass of: lymphatic vessel tumor
subclass of: sarcoma
definition: A malignant neoplasm derived from vascular tissue in which the neoplastic cells originate from the endothelial cells of lymphatic vessels. (M-9170/3).
has_obo_namespace: mouse_pathology.ontology
id: MPATH:422

Axiom
annotated source: lymphangiosarcoma
annotated property: definition
annotated target: A malignant neoplasm derived from vascular tissue in which the neoplastic cells originate from the endothelial cells of lymphatic vessels. (M-9170/3).
database_cross_reference: Pathbase: Curation

myomatous tumor
type: Class
subclass of: soft tissue tumor
definition: Neoplasms derived from myogenic lineages or predominantly composed of cells showing myomatous differentiation.
has_obo_namespace: mouse_pathology.ontology
id: MPATH:423

Axiom
annotated source: myomatous tumor
annotated property: definition
annotated target: Neoplasms derived from myogenic lineages or predominantly composed of cells showing myomatous differentiation.
database_cross_reference: Pathbase: Curation

intravascular leiomyomatosis
type: Class
subclass of: myomatous tumor
definition: Benign leiomyoma that invades vascular spaces. (M-8890/1).
has_obo_namespace: mouse_pathology.ontology
id: MPATH:424

Axiom
annotated source: intravascular leiomyomatosis
annotated property: definition
annotated target: Benign leiomyoma that invades vascular spaces. (M-8890/1).
database_cross_reference: Pathbase: Curation

leiomyoma
type: Class
subclass of: myomatous tumor
definition: Benign neoplasm derived from smooth muscle cells. (M-8890/0).
has_obo_namespace: mouse_pathology.ontology
id: MPATH:425

Axiom
annotated source: leiomyoma
annotated property: definition
annotated target: Benign neoplasm derived from smooth muscle cells. (M-8890/0).
database_cross_reference: Pathbase: Curation

leiomyosarcoma
type: Class
subclass of: myomatous tumor
subclass of: sarcoma
definition: Malignant tumor derived form pluripotential mesenchymal stem cells or smooth muscle cells. (M- 8890/3).
has_obo_namespace: mouse_pathology.ontology
id: MPATH:426

Axiom
annotated source: leiomyosarcoma
annotated property: definition
annotated target: Malignant tumor derived form pluripotential mesenchymal stem cells or smooth muscle cells. (M- 8890/3).
database_cross_reference: Pathbase: Curation

myoblastoma
type: Class
definition: myoblastoma
has_obo_namespace: mouse_pathology.ontology
id: MPATH:427
comment: obsolete. Syn of granular cell tumor. MPATH 413
deprecated: true

Axiom
annotated source: myoblastoma
annotated property: definition
annotated target: myoblastoma
database_cross_reference: Pathbase: Curation

rhabdomyosarcoma
type: Class
subclass of: myomatous tumor
subclass of: sarcoma
definition: Malignant tumor of striated muscle or pluripotential mesenchymal stem cells. (M-8900/3).
has_obo_namespace: mouse_pathology.ontology
id: MPATH:428

Axiom
annotated source: rhabdomyosarcoma
annotated property: definition
annotated target: Malignant tumor of striated muscle or pluripotential mesenchymal stem cells. (M-8900/3).
database_cross_reference: Pathbase: Curation

myxomatous tumor
type: Class
subclass of: soft tissue tumor
definition: Neoplasms resembling primitive mesenchymal tissue with a soft mucous matrix.
has_obo_namespace: mouse_pathology.ontology
id: MPATH:429

Axiom
annotated source: myxomatous tumor
annotated property: definition
annotated target: Neoplasms resembling primitive mesenchymal tissue with a soft mucous matrix.
database_cross_reference: Pathbase: Curation

lipofuscin deposition
type: Class
subclass of: pigmentation
definition: Intracellular deposition of brown pigment granules probably representing lipid-containing residues of lysosomal digestion. Often age related.
has_obo_namespace: mouse_pathology.ontology
id: MPATH:43

Axiom
annotated source: lipofuscin deposition
annotated property: definition
annotated target: Intracellular deposition of brown pigment granules probably representing lipid-containing residues of lysosomal digestion. Often age related.
database_cross_reference: Pathbase: Pathology Committee

angiomyxoma
type: Class
subclass of: myxomatous tumor
definition: Angiomyxoma is a poorly circumscribed, slowly growing lesion composed of spindle-shaped and stellate cells evenly distributed in an abundant myxoid matrix. The lesion contains numerous vessels, often showing some hyalinization of their walls, and occasionally surrounded by a few smooth muscle cells. Immunohistochemically, tumor cells may express desmin and/ or smooth muscle actin (M-8841/1).
has_obo_namespace: mouse_pathology.ontology
id: MPATH:430

Axiom
annotated source: angiomyxoma
annotated property: definition
annotated target: Angiomyxoma is a poorly circumscribed, slowly growing lesion composed of spindle-shaped and stellate cells evenly distributed in an abundant myxoid matrix. The lesion contains numerous vessels, often showing some hyalinization of their walls, and occasionally surrounded by a few smooth muscle cells. Immunohistochemically, tumor cells may express desmin and/ or smooth muscle actin (M-8841/1).
database_cross_reference: Pathbase: Curation

myxoma
type: Class
subclass of: myxomatous tumor
definition: A benign neoplasm derived from pluripotential mesenchymal stem cells of connective tissue, consisting chiefly of polyhedral and stellate cells that are loosely embedded in a soft mucoid matrix. May show multiple differentiated components. (M-8840/0).
has_obo_namespace: mouse_pathology.ontology
id: MPATH:431

Axiom
annotated source: myxoma
annotated property: definition
annotated target: A benign neoplasm derived from pluripotential mesenchymal stem cells of connective tissue, consisting chiefly of polyhedral and stellate cells that are loosely embedded in a soft mucoid matrix. May show multiple differentiated components. (M-8840/0).
database_cross_reference: Pathbase: Pathology Committee

myxosarcoma
type: Class
subclass of: myxomatous tumor
subclass of: sarcoma
definition: A malignant neoplasm derived from pluripotential mesenchymal stem cells of connective tissue, consisting chiefly of polyhedral and stellate cells that are loosely embedded in a soft mucoid matrix. (M-8840/3).
has_obo_namespace: mouse_pathology.ontology
id: MPATH:432

Axiom
annotated source: myxosarcoma
annotated property: definition
annotated target: A malignant neoplasm derived from pluripotential mesenchymal stem cells of connective tissue, consisting chiefly of polyhedral and stellate cells that are loosely embedded in a soft mucoid matrix. (M-8840/3).
database_cross_reference: Pathbase: Curation

nerve sheath tumor
type: Class
subclass of: soft tissue tumor
subclass of: peripheral nervous system tumors
definition: Neoplasms of the nerve sheath.
has_obo_namespace: mouse_pathology.ontology
id: MPATH:433

Axiom
annotated source: nerve sheath tumor
annotated property: definition
annotated target: Neoplasms of the nerve sheath.
database_cross_reference: Pathbase: Pathology Committee

neurilemmoma
type: Class
definition: neurilemmoma
has_obo_namespace: mouse_pathology.ontology
id: MPATH:434
comment: obsolete. Use schwannoma MPATH438
deprecated: true

Axiom
annotated source: neurilemmoma
annotated property: definition
annotated target: neurilemmoma
database_cross_reference: Pathbase: Curation

neurofibroma
type: Class
subclass of: nerve sheath tumor
definition: Peripheral nerve tumor consisting of chaotic arrays of wavy schwann cell bundles and fibroblasts interspersed within a matrix rich in collagen and mucopolysaccharide. (M9540/0).
has_obo_namespace: mouse_pathology.ontology
id: MPATH:435

Axiom
annotated source: neurofibroma
annotated property: definition
annotated target: Peripheral nerve tumor consisting of chaotic arrays of wavy schwann cell bundles and fibroblasts interspersed within a matrix rich in collagen and mucopolysaccharide. (M9540/0).
database_cross_reference: ISBN-13:9783794515530

neurofibromatosis
type: Class
subclass of: nerve sheath tumor
definition: Systemic manifestation of MPATH:435 ( M-9540/1).
has_obo_namespace: mouse_pathology.ontology
id: MPATH:436

Axiom
annotated source: neurofibromatosis
annotated property: definition
annotated target: Systemic manifestation of MPATH:435 ( M-9540/1).
database_cross_reference: Pathbase: Curation

neurofibrosarcoma
type: Class
subclass of: nerve sheath tumor
subclass of: sarcoma
definition: Malignant neoplasm derived from Schwann cells. (M-9540/3).
has_obo_namespace: mouse_pathology.ontology
has_related_synonym: malignant peripheral nerve sheath tumor
id: MPATH:437

Axiom
annotated source: neurofibrosarcoma
annotated property: definition
annotated target: Malignant neoplasm derived from Schwann cells. (M-9540/3).
database_cross_reference: ISBN-13:9783794515530

Axiom
annotated source: neurofibrosarcoma
annotated property: has_related_synonym
annotated target: malignant peripheral nerve sheath tumor
database_cross_reference: Pathbase: Curation

schwannoma
type: Class
subclass of: nerve sheath tumor
definition: May be malignant or benign, Schwann cell derived tumor considered to be neurectodermal with some acquired mesenchymal features. (M-9560/0).
has_obo_namespace: mouse_pathology.ontology
has_related_synonym: neurilemoma
has_related_synonym: neurinoma, benign
id: MPATH:438

Axiom
annotated source: schwannoma
annotated property: definition
annotated target: May be malignant or benign, Schwann cell derived tumor considered to be neurectodermal with some acquired mesenchymal features. (M-9560/0).
database_cross_reference: ISBN-13:9783794515530

Axiom
annotated source: schwannoma
annotated property: has_related_synonym
annotated target: neurilemoma
database_cross_reference: Pathbase: Curation

Axiom
annotated source: schwannoma
annotated property: has_related_synonym
annotated target: neurinoma, benign
database_cross_reference: Pathbase: Curation

synovial-like tumor
type: Class
subclass of: soft tissue tumor
definition: Neoplasms of synovial origin.
has_obo_namespace: mouse_pathology.ontology
id: MPATH:439

Axiom
annotated source: synovial-like tumor
annotated property: definition
annotated target: Neoplasms of synovial origin.
database_cross_reference: Pathbase: Curation

melanin deposition
type: Class
subclass of: pigmentation
definition: Intra or extracellular deposition of melanin.
has_obo_namespace: mouse_pathology.ontology
id: MPATH:44

Axiom
annotated source: melanin deposition
annotated property: definition
annotated target: Intra or extracellular deposition of melanin.
database_cross_reference: Pathbase: Pathology Committee

synovial sarcoma
type: Class
subclass of: synovial-like tumor
subclass of: sarcoma
definition: Malignant neoplasm occurring in close association with tendon sheaths and joint capsules. Biphasic in humans , showing a mixed spindle cell and epithelioid like morphology; this is not seen in rodents to date. (M-9040/3).
has_obo_namespace: mouse_pathology.ontology
has_related_synonym: Synovial cell sarcoma
id: MPATH:440

Axiom
annotated source: synovial sarcoma
annotated property: definition
annotated target: Malignant neoplasm occurring in close association with tendon sheaths and joint capsules. Biphasic in humans , showing a mixed spindle cell and epithelioid like morphology; this is not seen in rodents to date. (M-9040/3).
database_cross_reference: Pathbase: Pathology Committee

Axiom
annotated source: synovial sarcoma
annotated property: has_related_synonym
annotated target: Synovial cell sarcoma
database_cross_reference: Pathbase: Curation

synovioma
type: Class
definition: synovioma
has_obo_namespace: mouse_pathology.ontology
id: MPATH:441
comment: Obsolete. Use MPATH:440
deprecated: true

Axiom
annotated source: synovioma
annotated property: definition
annotated target: synovioma
database_cross_reference: Pathbase: Curation

squamous cell tumor
type: Class
subclass of: neoplasm
definition: Neoplasms of stratified squamous epithelial cells.
has_obo_namespace: mouse_pathology.ontology
id: MPATH:442

Axiom
annotated source: squamous cell tumor
annotated property: definition
annotated target: Neoplasms of stratified squamous epithelial cells.
database_cross_reference: Pathbase: Pathology Committee

inverted squamous papilloma
type: Class
subclass of: adnexal and skin appendage tumor
subclass of: squamous cell tumor
subclass of: papilloma
definition: A benign tumor consisting of villous or arborescent outgrowths of fibrovascular stroma covered by neoplastic epithelial cells in which proliferating epithelium is invaginated beneath the surface and is more smoothly rounded. (M-8053/0).
has_obo_namespace: mouse_pathology.ontology
has_related_synonym: endophytic papilloma
has_related_synonym: invaginated papilloma
id: MPATH:443

Axiom
annotated source: inverted squamous papilloma
annotated property: definition
annotated target: A benign tumor consisting of villous or arborescent outgrowths of fibrovascular stroma covered by neoplastic epithelial cells in which proliferating epithelium is invaginated beneath the surface and is more smoothly rounded. (M-8053/0).
database_cross_reference: Pathbase: Pathology Committee

Axiom
annotated source: inverted squamous papilloma
annotated property: has_related_synonym
annotated target: endophytic papilloma
database_cross_reference: Pathbase: Curation

Axiom
annotated source: inverted squamous papilloma
annotated property: has_related_synonym
annotated target: invaginated papilloma
database_cross_reference: Pathbase: Curation

keratoacanthoma
type: Class
subclass of: adnexal and skin appendage tumor
subclass of: squamous cell tumor
definition: Skin type is thought to arise from follicular epithelium of hair follicles; found in other epithelia. Composed of multiple cup shaped cavities filled with lamellated concentrically arranged or homogeneous cornified masses.
has_obo_namespace: mouse_pathology.ontology
has_related_synonym: epithelioma, intracutaneous, cornifying
id: MPATH:444

Axiom
annotated source: keratoacanthoma
annotated property: definition
annotated target: Skin type is thought to arise from follicular epithelium of hair follicles; found in other epithelia. Composed of multiple cup shaped cavities filled with lamellated concentrically arranged or homogeneous cornified masses.
database_cross_reference: Pathbase: Pathology Committee

Axiom
annotated source: keratoacanthoma
annotated property: has_related_synonym
annotated target: epithelioma, intracutaneous, cornifying
database_cross_reference: Pathbase: Curation

papilloma
type: Class
subclass of: fibroepithelial tumor
subclass of: potentially cancerous lesions
definition: A benign tumor consisting of villous or arborescent outgrowths of fibrovascular stroma covered by neoplastic epithelial cells (M-8050/0).
has_obo_namespace: mouse_pathology.ontology
id: MPATH:445

Axiom
annotated source: papilloma
annotated property: definition
annotated target: A benign tumor consisting of villous or arborescent outgrowths of fibrovascular stroma covered by neoplastic epithelial cells (M-8050/0).
database_cross_reference: Pathbase: Pathology Committee

squamous cell carcinoma
type: Class
subclass of: adnexal and skin appendage tumor
subclass of: squamous cell tumor
subclass of: carcinoma
definition: Malignant tumor derived from stratified squamous cells. (M-8070/3).
has_obo_namespace: mouse_pathology.ontology
has_related_synonym: carcinoma, epidermoid ( sensu epidermal derived tumors)
id: MPATH:446

Axiom
annotated source: squamous cell carcinoma
annotated property: definition
annotated target: Malignant tumor derived from stratified squamous cells. (M-8070/3).
database_cross_reference: Pathbase: Pathology Committee

Axiom
annotated source: squamous cell carcinoma
annotated property: has_related_synonym
annotated target: carcinoma, epidermoid ( sensu epidermal derived tumors)
database_cross_reference: Pathbase: Curation

squamous cell carcinoma in situ
type: Class
subclass of: adnexal and skin appendage tumor
subclass of: squamous cell tumor
subclass of: potentially cancerous lesions
definition: Pre-neoplastic intraepithelial lesion of squamous cells (M-8070/2).
has_obo_namespace: mouse_pathology.ontology
has_related_synonym: IENIII
has_related_synonym: severe intra-epithelial neoplasia
id: MPATH:447

Axiom
annotated source: squamous cell carcinoma in situ
annotated property: definition
annotated target: Pre-neoplastic intraepithelial lesion of squamous cells (M-8070/2).
database_cross_reference: Pathbase: Pathology Committee

Axiom
annotated source: squamous cell carcinoma in situ
annotated property: has_related_synonym
annotated target: IENIII
database_cross_reference: Pathbase: Curation

Axiom
annotated source: squamous cell carcinoma in situ
annotated property: has_related_synonym
annotated target: severe intra-epithelial neoplasia
database_cross_reference: Pathbase: Curation

squamous cell papilloma
type: Class
subclass of: adnexal and skin appendage tumor
subclass of: squamous cell tumor
subclass of: papilloma
definition: A benign tumor consisting of villous or arborescent outgrowths of fibrovascular stroma covered by neoplastic squamous epithelial cells.
has_obo_namespace: mouse_pathology.ontology
has_related_synonym: Exophytic papilloma
id: MPATH:448

Axiom
annotated source: squamous cell papilloma
annotated property: definition
annotated target: A benign tumor consisting of villous or arborescent outgrowths of fibrovascular stroma covered by neoplastic squamous epithelial cells.
database_cross_reference: Pathbase: Pathology Committee

Axiom
annotated source: squamous cell papilloma
annotated property: has_related_synonym
annotated target: Exophytic papilloma
database_cross_reference: Pathbase: Curation

verrucous carcinoma
type: Class
subclass of: squamous cell tumor
subclass of: carcinoma
definition: A well-differentiated papillary squamous cell carcinoma. (M-8051/3).
has_obo_namespace: mouse_pathology.ontology
id: MPATH:449

Axiom
annotated source: verrucous carcinoma
annotated property: definition
annotated target: A well-differentiated papillary squamous cell carcinoma. (M-8051/3).
database_cross_reference: Pathbase: Curation

protein deposition
type: Class
subclass of: intracellular and extracellular accumulation
definition: Non-specified intra or extracellular deposition of protein.
has_obo_namespace: mouse_pathology.ontology
id: MPATH:45

Axiom
annotated source: protein deposition
annotated property: definition
annotated target: Non-specified intra or extracellular deposition of protein.
database_cross_reference: Pathbase: Curation

transitional cell tumor
type: Class
subclass of: neoplasm
definition: Neoplasms of transitional epithelia, eg kidney, ureter , bladder , cervix.
has_obo_namespace: mouse_pathology.ontology
id: MPATH:450

Axiom
annotated source: transitional cell tumor
annotated property: definition
annotated target: Neoplasms of transitional epithelia, eg kidney, ureter , bladder , cervix.
database_cross_reference: Pathbase: Pathology Committee

transitional cell carcinoma
type: Class
subclass of: transitional cell tumor
subclass of: carcinoma
definition: Malignant neoplasm of transitional cells (M-8120/3).
has_obo_namespace: mouse_pathology.ontology
id: MPATH:451

Axiom
annotated source: transitional cell carcinoma
annotated property: definition
annotated target: Malignant neoplasm of transitional cells (M-8120/3).
database_cross_reference: Pathbase: Curation

transitional cell carcinoma in situ
type: Class
subclass of: transitional cell tumor
subclass of: potentially cancerous lesions
definition: Pre-malignant intra-epithelial neoplasm of transitional cells (M-8120/2).
has_obo_namespace: mouse_pathology.ontology
has_related_synonym: severe intra-epithelial neoplasia
id: MPATH:452

Axiom
annotated source: transitional cell carcinoma in situ
annotated property: definition
annotated target: Pre-malignant intra-epithelial neoplasm of transitional cells (M-8120/2).
database_cross_reference: Pathbase: Pathology Committee

Axiom
annotated source: transitional cell carcinoma in situ
annotated property: has_related_synonym
annotated target: severe intra-epithelial neoplasia
database_cross_reference: Pathbase: Curation

transitional cell papilloma
type: Class
subclass of: transitional cell tumor
definition: Pre-malignant lesion of transitional cells, papillomatous form ( M- 8120/1).
has_obo_namespace: mouse_pathology.ontology
id: MPATH:453

Axiom
annotated source: transitional cell papilloma
annotated property: definition
annotated target: Pre-malignant lesion of transitional cells, papillomatous form ( M- 8120/1).
database_cross_reference: Pathbase: Pathology Committee

trophoblastic tumor
type: Class
subclass of: neoplasm
definition: Tumors derived directly from trophoblastic tissue or differentiated from germ cell tumor origins.
has_obo_namespace: mouse_pathology.ontology
id: MPATH:454

Axiom
annotated source: trophoblastic tumor
annotated property: definition
annotated target: Tumors derived directly from trophoblastic tissue or differentiated from germ cell tumor origins.
database_cross_reference: Pathbase: Curation

choriocarcinoma
type: Class
subclass of: germ cell tumor
subclass of: trophoblastic tumor
definition: Tumor derived from malignant trophoblastic cells. May be found in the uterus, ovary and testis. May also be derived from teratomas and teratocarcinomas in males. (M-9100/3).
has_obo_namespace: mouse_pathology.ontology
has_related_synonym: Chorioepithelioma, malignant.
id: MPATH:455

Axiom
annotated source: choriocarcinoma
annotated property: definition
annotated target: Tumor derived from malignant trophoblastic cells. May be found in the uterus, ovary and testis. May also be derived from teratomas and teratocarcinomas in males. (M-9100/3).
database_cross_reference: Pathbase: Pathology Committee

Axiom
annotated source: choriocarcinoma
annotated property: has_related_synonym
annotated target: Chorioepithelioma, malignant.
database_cross_reference: Pathbase: Curation

hydatidiform mole
type: Class
subclass of: trophoblastic tumor
definition: Vesicular or cystic tumor with hydropic villi resulting from the proliferation of trophoblast in the absence ( complete) or the presence ( partial) of an embryo. Most complete moles are homozygous androgenetic XX 46.(M-9100/0).
has_obo_namespace: mouse_pathology.ontology
has_related_synonym: cystic mole
has_related_synonym: gestational trophoblastic disease
id: MPATH:456

Axiom
annotated source: hydatidiform mole
annotated property: definition
annotated target: Vesicular or cystic tumor with hydropic villi resulting from the proliferation of trophoblast in the absence ( complete) or the presence ( partial) of an embryo. Most complete moles are homozygous androgenetic XX 46.(M-9100/0).
database_cross_reference: Pathbase: Curation

Axiom
annotated source: hydatidiform mole
annotated property: has_related_synonym
annotated target: cystic mole
database_cross_reference: Pathbase: Curation

Axiom
annotated source: hydatidiform mole
annotated property: has_related_synonym
annotated target: gestational trophoblastic disease
database_cross_reference: Pathbase: Curation

placental site trophoblastic tumor
type: Class
subclass of: trophoblastic tumor
definition: Neoplastic proliferation of intermediate trophoblasts that invades the myometrium at the placental site after a pregnancy. (M-9104/1).
has_obo_namespace: mouse_pathology.ontology
id: MPATH:457

Axiom
annotated source: placental site trophoblastic tumor
annotated property: definition
annotated target: Neoplastic proliferation of intermediate trophoblasts that invades the myometrium at the placental site after a pregnancy. (M-9104/1).
database_cross_reference: Pathbase: Pathology Committee

normal
type: Class
subclass of: pathological phenotype observation
definition: No pathological entity observable.
has_obo_namespace: mouse_pathology.ontology
id: MPATH:458

Axiom
annotated source: normal
annotated property: definition
annotated target: No pathological entity observable.
database_cross_reference: Pathbase: Pathology Committee

obsolete
type: Class
definition: obsolete
has_obo_namespace: mouse_pathology.ontology
id: MPATH:459
deprecated: true

Axiom
annotated source: obsolete
annotated property: definition
annotated target: obsolete
database_cross_reference: Pathbase: Pathology Committee

uric acid deposition
type: Class
subclass of: intracellular and extracellular accumulation
definition: Extracellular deposition of uric acid crystals.
has_obo_namespace: mouse_pathology.ontology
id: MPATH:46

Axiom
annotated source: uric acid deposition
annotated property: definition
annotated target: Extracellular deposition of uric acid crystals.
database_cross_reference: Pathbase: Curation

nuclear defect
type: Class
subclass of: subcellular defect
definition: Defect in the structure or function of the nuclear membrane or matrix or other component.
has_obo_namespace: mouse_pathology.ontology
id: MPATH:460

Axiom
annotated source: nuclear defect
annotated property: definition
annotated target: Defect in the structure or function of the nuclear membrane or matrix or other component.
database_cross_reference: Pathbase: Curation

cataract; capsular-epithelial
type: Class
subclass of: cataract
definition: Proliferation of lens epithelium and capsule leading to fibrous metaplasia and anterior subcapsular cataract ( ASC) . Possible developmental origin.
has_obo_namespace: mouse_pathology.ontology
id: MPATH:461

Axiom
annotated source: cataract; capsular-epithelial
annotated property: definition
annotated target: Proliferation of lens epithelium and capsule leading to fibrous metaplasia and anterior subcapsular cataract ( ASC) . Possible developmental origin.
database_cross_reference: ISBN:08493086 4X

cataract; nuclear and cortical
type: Class
subclass of: cataract
definition: Nuclear cataract of developmental origin with tendency to progress with age and involve the cortex and capsule.
has_obo_namespace: mouse_pathology.ontology
id: MPATH:462

Axiom
annotated source: cataract; nuclear and cortical
annotated property: definition
annotated target: Nuclear cataract of developmental origin with tendency to progress with age and involve the cortex and capsule.
database_cross_reference: ISBN:08493086 4X

cataract; cortical liquefactive
type: Class
subclass of: cataract
definition: Of developmental origins; nucleus and cortex become completely liquefied in post-natal life.
has_obo_namespace: mouse_pathology.ontology
id: MPATH:463

Axiom
annotated source: cataract; cortical liquefactive
annotated property: definition
annotated target: Of developmental origins; nucleus and cortex become completely liquefied in post-natal life.
database_cross_reference: ISBN:08493086 4X

cataract; lens extrusion
type: Class
subclass of: cataract
definition: Involves capsular rupture usually of the posterior lens capsule, close to birth or in the first few weeks postpartum. Cortical material spills into the vitreous humor and may be disseminated through the eye.
has_obo_namespace: mouse_pathology.ontology
id: MPATH:464

Axiom
annotated source: cataract; lens extrusion
annotated property: definition
annotated target: Involves capsular rupture usually of the posterior lens capsule, close to birth or in the first few weeks postpartum. Cortical material spills into the vitreous humor and may be disseminated through the eye.
database_cross_reference: ISBN:08493086 4X

glaucoma developmental
type: Class
subclass of: glaucoma
definition: Consequent on developmental abnormalities in the trabecular network and Schlemm`s canal in the angle.
has_obo_namespace: mouse_pathology.ontology
id: MPATH:465

Axiom
annotated source: glaucoma developmental
annotated property: definition
annotated target: Consequent on developmental abnormalities in the trabecular network and Schlemm`s canal in the angle.
database_cross_reference: ISBN:08493086 4X

glaucoma; open angle
type: Class
subclass of: glaucoma
definition: Failure of drainage of the eye for unknown reasons.
has_obo_namespace: mouse_pathology.ontology
id: MPATH:466

Axiom
annotated source: glaucoma; open angle
annotated property: definition
annotated target: Failure of drainage of the eye for unknown reasons.
database_cross_reference: ISBN:08493086 4X

glaucoma; angle closure
type: Class
subclass of: glaucoma
definition: Develops when the angle caused by the iris and cornea closes. May occur because of anatomically narrow angles or adhesions.
has_obo_namespace: mouse_pathology.ontology
id: MPATH:467

Axiom
annotated source: glaucoma; angle closure
annotated property: definition
annotated target: Develops when the angle caused by the iris and cornea closes. May occur because of anatomically narrow angles or adhesions.
database_cross_reference: ISBN:08493086 4X

pseudocyst
type: Class
subclass of: cell and tissue damage
definition: Formation of extracellular (sensu pancreas) non-epithelial bounded spaces containing accumulated products or substances.
has_obo_namespace: mouse_pathology.ontology
id: MPATH:468

Axiom
annotated source: pseudocyst
annotated property: definition
annotated target: Formation of extracellular (sensu pancreas) non-epithelial bounded spaces containing accumulated products or substances.
database_cross_reference: Pathbase: Pathology Committee

symmetry defect
type: Class
subclass of: developmental or adult structural defect
definition: Any aberration of the normal symmetrical organisation of the body pattern.
has_obo_namespace: mouse_pathology.ontology
id: MPATH:469

Axiom
annotated source: symmetry defect
annotated property: definition
annotated target: Any aberration of the normal symmetrical organisation of the body pattern.
database_cross_reference: Pathbase: Curation

intracellular and extracellular depletion
type: Class
subclass of: cell and tissue damage
definition: Loss or dispersion of specific intra- and extracellular substances.
has_obo_namespace: mouse_pathology.ontology
id: MPATH:47

Axiom
annotated source: intracellular and extracellular depletion
annotated property: definition
annotated target: Loss or dispersion of specific intra- and extracellular substances.
database_cross_reference: Pathbase: Pathology Committee

left/right axis defect
type: Class
subclass of: symmetry defect
definition: Left/Right (mediolateral) axis aberration of the normal symmetrical organisation of the body pattern.
has_obo_namespace: mouse_pathology.ontology
id: MPATH:470
comment: For example as seen in the mutation <situs inversus>.

Axiom
annotated source: left/right axis defect
annotated property: definition
annotated target: Left/Right (mediolateral) axis aberration of the normal symmetrical organisation of the body pattern.
database_cross_reference: Pathbase: Pathology Committee

anterior/posterior axis defect
type: Class
subclass of: symmetry defect
definition: Anteroposterior aberration of the normal symmetrical organisation of the body pattern.
has_obo_namespace: mouse_pathology.ontology
id: MPATH:471

Axiom
annotated source: anterior/posterior axis defect
annotated property: definition
annotated target: Anteroposterior aberration of the normal symmetrical organisation of the body pattern.
database_cross_reference: Pathbase: Curation

dorsal/ventral axis defect
type: Class
subclass of: symmetry defect
definition: Dorsoventral aberration of the normal symmetrical organisation of the body pattern.
has_obo_namespace: mouse_pathology.ontology
id: MPATH:472

Axiom
annotated source: dorsal/ventral axis defect
annotated property: definition
annotated target: Dorsoventral aberration of the normal symmetrical organisation of the body pattern.
database_cross_reference: Pathbase: Curation

developmental cystic dysplasia
type: Class
subclass of: developmental dysplasia
definition: Developmental dysplasia showing epithelial cell bounded cavities.
has_obo_namespace: mouse_pathology.ontology
id: MPATH:473

Axiom
annotated source: developmental cystic dysplasia
annotated property: definition
annotated target: Developmental dysplasia showing epithelial cell bounded cavities.
database_cross_reference: Pathbase: Pathology Committee

ectasia
type: Class
subclass of: dilatation
definition: Dilation of a tubular structure.
has_obo_namespace: mouse_pathology.ontology
id: MPATH:474
comment: Often associated with an obstruction.

Axiom
annotated source: ectasia
annotated property: definition
annotated target: Dilation of a tubular structure.
database_cross_reference: Pathbase: Pathology Committee

ductal ectasia
type: Class
subclass of: ectasia
definition: Dilation of a ductal structure.
has_obo_namespace: mouse_pathology.ontology
id: MPATH:475

Axiom
annotated source: ductal ectasia
annotated property: definition
annotated target: Dilation of a ductal structure.
database_cross_reference: Pathbase: Curation

telangiectasia
type: Class
subclass of: ectasia
definition: A lesion formed by a dilated capillary or terminal artery.
has_obo_namespace: mouse_pathology.ontology
id: MPATH:476

Axiom
annotated source: telangiectasia
annotated property: definition
annotated target: A lesion formed by a dilated capillary or terminal artery.
database_cross_reference: Pathbase: Curation

choristoma
type: Class
subclass of: developmental or adult structural defect
definition: Similar to hamartoma, including the mass lesion requirement, but unlike hamartoma, includes heterotopic tissue of an adult or embryonic nature ( topographical and developmental anomaly).
has_obo_namespace: mouse_pathology.ontology
has_related_synonym: Choristoblastoma
id: MPATH:477

Axiom
annotated source: choristoma
annotated property: definition
annotated target: Similar to hamartoma, including the mass lesion requirement, but unlike hamartoma, includes heterotopic tissue of an adult or embryonic nature ( topographical and developmental anomaly).
database_cross_reference: ISBN:0781727286

Axiom
annotated source: choristoma
annotated property: has_related_synonym
annotated target: Choristoblastoma
database_cross_reference: Pathbase: Curation

angiogenesis defect
type: Class
subclass of: developmental process abnormalities
definition: Abnormality in developmental angiogenesis.
has_obo_namespace: mouse_pathology.ontology
id: MPATH:478

Axiom
annotated source: angiogenesis defect
annotated property: definition
annotated target: Abnormality in developmental angiogenesis.
database_cross_reference: Pathbase: Pathology Committee

vasculogenesis defect
type: Class
subclass of: developmental process abnormalities
definition: Defect in formation of blood vessels by vasculogenesis, proliferation or recruitment of endothelial cells.
has_obo_namespace: mouse_pathology.ontology
id: MPATH:479

Axiom
annotated source: vasculogenesis defect
annotated property: definition
annotated target: Defect in formation of blood vessels by vasculogenesis, proliferation or recruitment of endothelial cells.
database_cross_reference: Pathbase: Pathology Committee

decalcification
type: Class
subclass of: intracellular and extracellular depletion
definition: Process of loss of calcium from normally calcified tissue, usually bone.
has_obo_namespace: mouse_pathology.ontology
id: MPATH:48

Axiom
annotated source: decalcification
annotated property: definition
annotated target: Process of loss of calcium from normally calcified tissue, usually bone.
database_cross_reference: Pathbase: Curation

decidual defect
type: Class
subclass of: placental abnormality
definition: Any defect in the formation, architecture, cellular composition or function of the maternal decidua.
has_obo_namespace: mouse_pathology.ontology
id: MPATH:480

Axiom
annotated source: decidual defect
annotated property: definition
annotated target: Any defect in the formation, architecture, cellular composition or function of the maternal decidua.
database_cross_reference: Pathbase: Curation

pre-neoplastic lesions
type: Class
definition: Lesions likely to result in progression to frank tumors, which may be classified as pre-neoplastic or pre-cancerous.
has_obo_namespace: mouse_pathology.ontology
id: MPATH:481
comment: Obsolete; replaced by potentially pre-cancerous lesions (MPATH 556) as many are actually neoplastic but do not progress to cancer.
deprecated: true

Axiom
annotated source: pre-neoplastic lesions
annotated property: definition
annotated target: Lesions likely to result in progression to frank tumors, which may be classified as pre-neoplastic or pre-cancerous.
database_cross_reference: Journal: Ward; J.M. ( 2002) J Toxicol. Pathol. 15; 123-128

focal hyperplasia
type: Class
subclass of: hyperplastic tissue
definition: Localised hyperplastic lesion. Polyclonal lesions are probably benign but clonal lesions may progress to malignancy.
has_obo_namespace: mouse_pathology.ontology
id: MPATH:482

Axiom
annotated source: focal hyperplasia
annotated property: definition
annotated target: Localised hyperplastic lesion. Polyclonal lesions are probably benign but clonal lesions may progress to malignancy.
database_cross_reference: Pathbase: Pathology Committee

atypical hyperplasia
type: Class
definition: Presence of localised areas within for example adenomas showing characteristics of neoplastic (tumor) progression, eg focal carcinoma.
has_obo_namespace: mouse_pathology.ontology
id: MPATH:483
comment: Considered to be too vague to be useful.
deprecated: true

Axiom
annotated source: atypical hyperplasia
annotated property: definition
annotated target: Presence of localised areas within for example adenomas showing characteristics of neoplastic (tumor) progression, eg focal carcinoma.
database_cross_reference: Pathbase: Pathology Committee

hyperplastic nodule
type: Class
subclass of: hyperplastic tissue
definition: Expansion of small hyperplastic lesions to become macroscopically nodules, compressing adjacent cells.
has_obo_namespace: mouse_pathology.ontology
has_related_synonym: hyperplastic nodules
has_related_synonym: nodular hyperplasia
id: MPATH:484

Axiom
annotated source: hyperplastic nodule
annotated property: definition
annotated target: Expansion of small hyperplastic lesions to become macroscopically nodules, compressing adjacent cells.
database_cross_reference: Pathbase: Pathology Committee

Axiom
annotated source: hyperplastic nodule
annotated property: has_related_synonym
annotated target: hyperplastic nodules
database_cross_reference: Pathbase: Curation

carcinoma in situ
type: Class
definition: May be used in some systems in preference to its synonyms to indicate lesion specific aprearances. A lesion characterised by changes of the type associated with invasive carcinoma, but physically bounded by the lining epithelium and without local invasion.
has_obo_namespace: mouse_pathology.ontology
has_related_synonym: severe epithelial dysplasia
has_related_synonym: severe intraepithelial neoplasia
id: MPATH:485
comment: Subsumed into MPATH: 132
deprecated: true

Axiom
annotated source: carcinoma in situ
annotated property: definition
annotated target: May be used in some systems in preference to its synonyms to indicate lesion specific aprearances. A lesion characterised by changes of the type associated with invasive carcinoma, but physically bounded by the lining epithelium and without local invasion.
database_cross_reference: Pathbase: Pathology Committee

Axiom
annotated source: carcinoma in situ
annotated property: has_related_synonym
annotated target: severe epithelial dysplasia
database_cross_reference: Pathbase: Curation

Axiom
annotated source: carcinoma in situ
annotated property: has_related_synonym
annotated target: severe intraepithelial neoplasia
database_cross_reference: Pathbase: Curation

ductal intra-epithelial neoplasia
type: Class
subclass of: glandular tumor
subclass of: potentially cancerous lesions
definition: Pre-malignant hyperplastic and/or dysplastic change in the mammary gland epithelium with the potential to give rise to malignant tumors.
has_obo_namespace: mouse_pathology.ontology
has_related_synonym: DIN
has_related_synonym: Ductal carcinoma in situ
has_related_synonym: MIN
has_related_synonym: intraductal adenocarcinoma, non-infiltrating
has_related_synonym: mammary intra-epithelial neoplasia
id: MPATH:486
comment: This term covers the range of DIN (MIN) including severe intra-epithelial neoplasia (IENIII), alternatively termed in situ carcinoma of the mammary ductal epithelium. (M- 8500/2). See Tavassoli FA. (1998) Mod Pathol. 11:140-54. Ductal carcinoma in situ: introduction of the concept of ductal intraepithelial neoplasia for further definition.

Axiom
annotated source: ductal intra-epithelial neoplasia
annotated property: definition
annotated target: Pre-malignant hyperplastic and/or dysplastic change in the mammary gland epithelium with the potential to give rise to malignant tumors.
database_cross_reference: PMID:10713680

Axiom
annotated source: ductal intra-epithelial neoplasia
annotated property: has_related_synonym
annotated target: DIN
database_cross_reference: Pathbase: Curation

Axiom
annotated source: ductal intra-epithelial neoplasia
annotated property: has_related_synonym
annotated target: Ductal carcinoma in situ
database_cross_reference: Pathbase: Curation

Axiom
annotated source: ductal intra-epithelial neoplasia
annotated property: has_related_synonym
annotated target: MIN
database_cross_reference: Pathbase: Curation

Axiom
annotated source: ductal intra-epithelial neoplasia
annotated property: has_related_synonym
annotated target: intraductal adenocarcinoma, non-infiltrating
database_cross_reference: Pathbase: Curation

Axiom
annotated source: ductal intra-epithelial neoplasia
annotated property: has_related_synonym
annotated target: mammary intra-epithelial neoplasia
database_cross_reference: Pathbase: Curation

intestinal intra-epithelial neoplasia
type: Class
subclass of: intra-epithelial neoplasia
definition: Histologically apparent areas of dysplasia that are not grossly visible (smaller than 0.5-1 mm). Lesions may involve single or multiple glands.
has_obo_namespace: mouse_pathology.ontology
has_related_synonym: GIN
has_related_synonym: IIN
has_related_synonym: microadenoma
id: MPATH:487

Axiom
annotated source: intestinal intra-epithelial neoplasia
annotated property: definition
annotated target: Histologically apparent areas of dysplasia that are not grossly visible (smaller than 0.5-1 mm). Lesions may involve single or multiple glands.
database_cross_reference: PMID:12612914

Axiom
annotated source: intestinal intra-epithelial neoplasia
annotated property: has_related_synonym
annotated target: GIN
database_cross_reference: Pathbase: Curation

Axiom
annotated source: intestinal intra-epithelial neoplasia
annotated property: has_related_synonym
annotated target: IIN
database_cross_reference: Pathbase: Curation

Axiom
annotated source: intestinal intra-epithelial neoplasia
annotated property: has_related_synonym
annotated target: microadenoma
database_cross_reference: Pathbase: Curation

prostate intra-epithelial neoplasia
type: Class
subclass of: intra-epithelial neoplasia
definition: See reference for definition.
database_cross_reference: URL: http://emice.nci.nih.gov/emice/mouse_models/organ_models/prostate_models/path_class_mouse
has_obo_namespace: mouse_pathology.ontology
has_related_synonym: PIN
id: MPATH:488

Axiom
annotated source: prostate intra-epithelial neoplasia
annotated property: definition
annotated target: See reference for definition.
database_cross_reference: ISBN:0-19-512338-7

Axiom
annotated source: prostate intra-epithelial neoplasia
annotated property: has_related_synonym
annotated target: PIN
database_cross_reference: Pathbase: Curation

stomach, oesophagus and pancreatic intra-epithelial neoplasia
type: Class
subclass of: intra-epithelial neoplasia
definition: stomach, oesophagus and pancreatic intra-epithelial neoplasia
has_obo_namespace: mouse_pathology.ontology
has_related_synonym: PANIN
id: MPATH:489

Axiom
annotated source: stomach, oesophagus and pancreatic intra-epithelial neoplasia
annotated property: definition
annotated target: stomach, oesophagus and pancreatic intra-epithelial neoplasia
database_cross_reference: ISBN:0-19-512338-7

Axiom
annotated source: stomach, oesophagus and pancreatic intra-epithelial neoplasia
annotated property: has_related_synonym
annotated target: PANIN
database_cross_reference: Pathbase: Curation

demyelination
type: Class
subclass of: intracellular and extracellular depletion
definition: Reduction of myelin content in neuronal sheath.
has_obo_namespace: mouse_pathology.ontology
id: MPATH:49

Axiom
annotated source: demyelination
annotated property: definition
annotated target: Reduction of myelin content in neuronal sheath.
database_cross_reference: Pathbase: Curation

adenomatous polyp
type: Class
subclass of: adenoma
subclass of: Restriction
  on property: part of
  some values from: adenomatous polyposis coli
definition: Benign neoplastic growth containing areas of adenomatous structure (progression).
has_obo_namespace: mouse_pathology.ontology
has_related_synonym: polypoid adenoma, cellular polyp.
id: MPATH:490

Axiom
annotated source: adenomatous polyp
annotated property: definition
annotated target: Benign neoplastic growth containing areas of adenomatous structure (progression).
database_cross_reference: Pathbase: Curation

Axiom
annotated source: adenomatous polyp
annotated property: has_related_synonym
annotated target: polypoid adenoma, cellular polyp.
database_cross_reference: Pathbase: Curation

polyp
type: Class
subclass of: epithelial hyperplasia
definition: A mass of tissue which projects outward or upward from the normal surface level being macroscopically visible as a hemispheroidal, spheroidal, or irregular moundlike structure growing from a relatively broad base or a slender stalk.
has_obo_namespace: mouse_pathology.ontology
id: MPATH:491

Axiom
annotated source: polyp
annotated property: definition
annotated target: A mass of tissue which projects outward or upward from the normal surface level being macroscopically visible as a hemispheroidal, spheroidal, or irregular moundlike structure growing from a relatively broad base or a slender stalk.
database_cross_reference: ISBN:0781727286

membraneous glomerulonephritis
type: Class
subclass of: glomerulonephritis
definition: Glomerulonephritis characterized by diffuse thickening of glomerular capillary basement membranes, due in part to subepithelial deposits of immunoglobulins separated by spikes of basement membrane material,.
has_obo_namespace: mouse_pathology.ontology
id: MPATH:492

Axiom
annotated source: membraneous glomerulonephritis
annotated property: definition
annotated target: Glomerulonephritis characterized by diffuse thickening of glomerular capillary basement membranes, due in part to subepithelial deposits of immunoglobulins separated by spikes of basement membrane material,.
database_cross_reference: ISBN:0781727286

membraneoproliferative glomerulonephritis
type: Class
subclass of: glomerulonephritis
definition: A chronic glomerulonephritis characterized by mesangial cell proliferation, increased lobular separation of glomeruli, thickening of glomerular capillary walls and increased mesangial matrix,.
has_obo_namespace: mouse_pathology.ontology
id: MPATH:493

Axiom
annotated source: membraneoproliferative glomerulonephritis
annotated property: definition
annotated target: A chronic glomerulonephritis characterized by mesangial cell proliferation, increased lobular separation of glomeruli, thickening of glomerular capillary walls and increased mesangial matrix,.
database_cross_reference: ISBN:0781727286

autoimmune glomerulonephritis
type: Class
subclass of: glomerulonephritis
definition: Glomerulonephritis caused by autoimmune attack on the glomerulus.
has_obo_namespace: mouse_pathology.ontology
id: MPATH:494
comment: Needs multiple parentage with autoimmune mediated disease

Axiom
annotated source: autoimmune glomerulonephritis
annotated property: definition
annotated target: Glomerulonephritis caused by autoimmune attack on the glomerulus.
database_cross_reference: ISBN:0781727286

glomangioma
type: Class
subclass of: blood vessel tumor
definition: Tumor derived from the capillary glomus with arteriovenous capillary anastomoses. Often characterized by multiple tumors resembling cavernous hemangioma (M-8712/0).
has_obo_namespace: mouse_pathology.ontology
id: MPATH:495

Axiom
annotated source: glomangioma
annotated property: definition
annotated target: Tumor derived from the capillary glomus with arteriovenous capillary anastomoses. Often characterized by multiple tumors resembling cavernous hemangioma (M-8712/0).
database_cross_reference: Pathbase: Curation

Non-Lymphoid leukaemias
type: Class
subclass of: non-Lymphoid neoplasias
definition: Neoplasms of non-lymphoid haematopoietic lineage. Must have at least 20% blast cells to meet this definition.
database_cross_reference: URL:http://www.bloodjournal.org/cgi/content/full/100/1/238/DC1/2
has_obo_namespace: mouse_pathology.ontology
id: MPATH:496

Axiom
annotated source: Non-Lymphoid leukaemias
annotated property: definition
annotated target: Neoplasms of non-lymphoid haematopoietic lineage. Must have at least 20% blast cells to meet this definition.
database_cross_reference: PMID:12070033

myeloid leukaemia without maturation
type: Class
subclass of: myeloid leukaemia
definition: Leukaemia in which neoplastic cells are poorly differentiated and not monocytic. At least 90% of the cells have to be blasts.
database_cross_reference: URL:http://www.bloodjournal.org/cgi/content/full/100/1/238/DC1/2
has_obo_namespace: mouse_pathology.ontology
has_related_synonym: myeloblastic leukaemia without maturation
has_related_synonym: myeloid leukaemia (myeloblastic type)
has_related_synonym: poorly differentiated myeloid leukaemia
id: MPATH:497

Axiom
annotated source: myeloid leukaemia without maturation
annotated property: definition
annotated target: Leukaemia in which neoplastic cells are poorly differentiated and not monocytic. At least 90% of the cells have to be blasts.
database_cross_reference: PMID:12070033

Axiom
annotated source: myeloid leukaemia without maturation
annotated property: has_related_synonym
annotated target: myeloblastic leukaemia without maturation
database_cross_reference: Pathbase: Curation

Axiom
annotated source: myeloid leukaemia without maturation
annotated property: has_related_synonym
annotated target: myeloid leukaemia (myeloblastic type)
database_cross_reference: Pathbase: Curation

Axiom
annotated source: myeloid leukaemia without maturation
annotated property: has_related_synonym
annotated target: poorly differentiated myeloid leukaemia
database_cross_reference: Pathbase: Curation

myeloid leukaemia with maturation
type: Class
subclass of: myeloid leukaemia
definition: Leukaemia in which neoplastic cells are moderately differentiated with a neutrophilic but not monocytic component. At least 20% of the cells have to be blasts.
database_cross_reference: URL:http://www.bloodjournal.org/cgi/content/full/100/1/238/DC1/2
has_obo_namespace: mouse_pathology.ontology
has_related_synonym: myeloblastic laeukaemia with maturation
has_related_synonym: poorly differentiated myeloid leukaemia
id: MPATH:498

Axiom
annotated source: myeloid leukaemia with maturation
annotated property: definition
annotated target: Leukaemia in which neoplastic cells are moderately differentiated with a neutrophilic but not monocytic component. At least 20% of the cells have to be blasts.
database_cross_reference: PMID:12070033

Axiom
annotated source: myeloid leukaemia with maturation
annotated property: has_related_synonym
annotated target: myeloblastic laeukaemia with maturation
database_cross_reference: Pathbase: Curation

Axiom
annotated source: myeloid leukaemia with maturation
annotated property: has_related_synonym
annotated target: poorly differentiated myeloid leukaemia
database_cross_reference: Pathbase: Curation

nesidioblastosis
type: Class
subclass of: developmental dysplasia
definition: Abnormal proliferation of beta cells of developing islets often leading to marked diffuse or focal beta-cell hyperplasia. Considered to generate a potentially cancerous lesion.
has_obo_namespace: mouse_pathology.ontology
has_related_synonym: Beta-cell nesidioblastosis
has_related_synonym: congenital insulinomas
has_related_synonym: diffused or generalised islet cell hyperplasia
has_related_synonym: endocrine dysplasia
has_related_synonym: focal adenomatosis
has_related_synonym: microadenomatosis
has_related_synonym: multifocal and focal ductulo-insular proliferation (nesidioblastosis)
has_related_synonym: nesidioblastoma
has_related_synonym: nesidiodysplasia
id: MPATH:499

Axiom
annotated source: nesidioblastosis
annotated property: definition
annotated target: Abnormal proliferation of beta cells of developing islets often leading to marked diffuse or focal beta-cell hyperplasia. Considered to generate a potentially cancerous lesion.
database_cross_reference: PMCID: 1964945

Axiom
annotated source: nesidioblastosis
annotated property: has_related_synonym
annotated target: Beta-cell nesidioblastosis
database_cross_reference: Pathbase: Curation

Axiom
annotated source: nesidioblastosis
annotated property: has_related_synonym
annotated target: congenital insulinomas
database_cross_reference: Pathbase: Curation

Axiom
annotated source: nesidioblastosis
annotated property: has_related_synonym
annotated target: diffused or generalised islet cell hyperplasia
database_cross_reference: Pathbase: Curation

Axiom
annotated source: nesidioblastosis
annotated property: has_related_synonym
annotated target: endocrine dysplasia
database_cross_reference: Pathbase: Curation

Axiom
annotated source: nesidioblastosis
annotated property: has_related_synonym
annotated target: focal adenomatosis
database_cross_reference: Pathbase: Curation

Axiom
annotated source: nesidioblastosis
annotated property: has_related_synonym
annotated target: microadenomatosis
database_cross_reference: Pathbase: Curation

Axiom
annotated source: nesidioblastosis
annotated property: has_related_synonym
annotated target: multifocal and focal ductulo-insular proliferation (nesidioblastosis)
database_cross_reference: Pathbase: Curation

Axiom
annotated source: nesidioblastosis
annotated property: has_related_synonym
annotated target: nesidioblastoma
database_cross_reference: Pathbase: Curation

Axiom
annotated source: nesidioblastosis
annotated property: has_related_synonym
annotated target: nesidiodysplasia
database_cross_reference: Pathbase: Curation

bridging necrosis
type: Class
subclass of: necrosis
definition: Area of liver necrosis that bridges adjacent portal areas and central veins.
has_obo_namespace: mouse_pathology.ontology
id: MPATH:5

Axiom
annotated source: bridging necrosis
annotated property: definition
annotated target: Area of liver necrosis that bridges adjacent portal areas and central veins.
database_cross_reference: ISBN:0781727286

glycogen depletion
type: Class
subclass of: intracellular and extracellular depletion
definition: Reduction in intracellular glycogen content.
has_obo_namespace: mouse_pathology.ontology
id: MPATH:50

Axiom
annotated source: glycogen depletion
annotated property: definition
annotated target: Reduction in intracellular glycogen content.
database_cross_reference: Pathbase: Curation

myeloproliferative disease-like myeloid leukaemia
type: Class
subclass of: myeloid leukaemia
definition: Leukaemia in which neoplastic cells are well differentiated and in which there are fewer than 20% blasts.
database_cross_reference: URL:http://www.bloodjournal.org/cgi/content/full/100/1/238/DC1/2
has_obo_namespace: mouse_pathology.ontology
has_related_synonym: myeloid leukaemia, chonic type
has_related_synonym: well differentiated myeloid leukaemia
id: MPATH:500

Axiom
annotated source: myeloproliferative disease-like myeloid leukaemia
annotated property: definition
annotated target: Leukaemia in which neoplastic cells are well differentiated and in which there are fewer than 20% blasts.
database_cross_reference: PMID:12070033

Axiom
annotated source: myeloproliferative disease-like myeloid leukaemia
annotated property: has_related_synonym
annotated target: myeloid leukaemia, chonic type
database_cross_reference: Pathbase: Curation

Axiom
annotated source: myeloproliferative disease-like myeloid leukaemia
annotated property: has_related_synonym
annotated target: well differentiated myeloid leukaemia
database_cross_reference: Pathbase: Curation

myelomonocytic leukaemia
type: Class
subclass of: myeloid leukaemia
definition: Leukaemia in which neoplastic cells are moderately differentiated with a neutrophilic and a monocytic component. At least 20% of the cells have to be blasts.
database_cross_reference: URL:http://www.bloodjournal.org/cgi/content/full/100/1/238/DC1/2
has_obo_namespace: mouse_pathology.ontology
has_related_synonym: myeloid leukaemia, myelomonocytic type
id: MPATH:501

Axiom
annotated source: myelomonocytic leukaemia
annotated property: definition
annotated target: Leukaemia in which neoplastic cells are moderately differentiated with a neutrophilic and a monocytic component. At least 20% of the cells have to be blasts.
database_cross_reference: PMID:12070033

Axiom
annotated source: myelomonocytic leukaemia
annotated property: has_related_synonym
annotated target: myeloid leukaemia, myelomonocytic type
database_cross_reference: Pathbase: Curation

monocytic leukaemia
type: Class
subclass of: myeloid leukaemia
definition: Leukaemia in which neoplastic cells are poorly or moderately differentiated with a monocytic but no neutrophilic component. At least 20% of the cells must be blasts.
database_cross_reference: URL:http://www.bloodjournal.org/cgi/content/full/100/1/238/DC1/2
has_obo_namespace: mouse_pathology.ontology
id: MPATH:502

Axiom
annotated source: monocytic leukaemia
annotated property: definition
annotated target: Leukaemia in which neoplastic cells are poorly or moderately differentiated with a monocytic but no neutrophilic component. At least 20% of the cells must be blasts.
database_cross_reference: PMID:12070033

biphenotypic leukaemia
type: Class
subclass of: Non-Lymphoid leukaemias
definition: A leukaemia with at least 90% blasts and differentiation markers of the myeloid and lymphoid lineage.
database_cross_reference: URL:http://www.bloodjournal.org/cgi/content/full/100/1/238/DC1/2
has_obo_namespace: mouse_pathology.ontology
id: MPATH:503

Axiom
annotated source: biphenotypic leukaemia
annotated property: definition
annotated target: A leukaemia with at least 90% blasts and differentiation markers of the myeloid and lymphoid lineage.
database_cross_reference: PMID:12070033

non-lymphoid hematopoietic sarcomas
type: Class
subclass of: hematopoietic/lymphoid malignancies/disorder
subclass of: sarcoma
definition: Solid tumor mass composed of non-lymphoid haematopoietic cells.
database_cross_reference: URL:http://www.bloodjournal.org/cgi/content/full/100/1/238/DC1/2
has_obo_namespace: mouse_pathology.ontology
id: MPATH:504

Axiom
annotated source: non-lymphoid hematopoietic sarcomas
annotated property: definition
annotated target: Solid tumor mass composed of non-lymphoid haematopoietic cells.
database_cross_reference: PMID:12070033

granulocytic sarcoma
type: Class
subclass of: non-lymphoid hematopoietic sarcomas
definition: Solid tumor mass composed predominantly of granulocytic or relatively undifferentiated non-lymphoid haematopoietic cells.
database_cross_reference: URL:http://www.bloodjournal.org/cgi/content/full/100/1/238/DC1/2
has_obo_namespace: mouse_pathology.ontology
id: MPATH:505

Axiom
annotated source: granulocytic sarcoma
annotated property: definition
annotated target: Solid tumor mass composed predominantly of granulocytic or relatively undifferentiated non-lymphoid haematopoietic cells.
database_cross_reference: PMID:12070033

histiocytic sarcoma
type: Class
subclass of: non-lymphoid hematopoietic sarcomas
definition: Solid tumor mass composed predominantly of histiocytic cells (M-9775/3).
database_cross_reference: URL:http://www.bloodjournal.org/cgi/content/full/100/1/238/DC1/2
has_obo_namespace: mouse_pathology.ontology
has_related_synonym: Kupffer cell sarcoma (sensu liver)
has_related_synonym: histiocytic lymphoma
has_related_synonym: malignant lymphoma, histiocytic type
has_related_synonym: reticulum cell sarcoma, type A
has_related_synonym: reticulum cell sarcoma, type A, reticulosarcoma
id: MPATH:506

Axiom
annotated source: histiocytic sarcoma
annotated property: definition
annotated target: Solid tumor mass composed predominantly of histiocytic cells (M-9775/3).
database_cross_reference: PMID:12070033

Axiom
annotated source: histiocytic sarcoma
annotated property: has_related_synonym
annotated target: Kupffer cell sarcoma (sensu liver)
database_cross_reference: Pathbase: Curation

Axiom
annotated source: histiocytic sarcoma
annotated property: has_related_synonym
annotated target: histiocytic lymphoma
database_cross_reference: Pathbase: Curation

Axiom
annotated source: histiocytic sarcoma
annotated property: has_related_synonym
annotated target: malignant lymphoma, histiocytic type
database_cross_reference: Pathbase: Curation

Axiom
annotated source: histiocytic sarcoma
annotated property: has_related_synonym
annotated target: reticulum cell sarcoma, type A
database_cross_reference: Pathbase: Curation

Axiom
annotated source: histiocytic sarcoma
annotated property: has_related_synonym
annotated target: reticulum cell sarcoma, type A, reticulosarcoma
database_cross_reference: Pathbase: Curation

mast cell sarcoma
type: Class
subclass of: non-lymphoid hematopoietic sarcomas
definition: Solid tumor mass composed of mast cells.
database_cross_reference: URL:http://www.bloodjournal.org/cgi/content/full/100/1/238/DC1/2
has_obo_namespace: mouse_pathology.ontology
has_related_synonym: malignant mastocytoma
has_related_synonym: mast cell tumor
has_related_synonym: mastocytosis
id: MPATH:507

Axiom
annotated source: mast cell sarcoma
annotated property: definition
annotated target: Solid tumor mass composed of mast cells.
database_cross_reference: PMID:12070033

Axiom
annotated source: mast cell sarcoma
annotated property: has_related_synonym
annotated target: malignant mastocytoma
database_cross_reference: Pathbase: Curation

Axiom
annotated source: mast cell sarcoma
annotated property: has_related_synonym
annotated target: mast cell tumor
database_cross_reference: Pathbase: Curation

Axiom
annotated source: mast cell sarcoma
annotated property: has_related_synonym
annotated target: mastocytosis
database_cross_reference: Pathbase: Curation

myeloid dysplasias
type: Class
subclass of: non-Lymphoid neoplasias
definition: Haematopoietic proliferation with evidence of trilineage dysplasia.
database_cross_reference: URL:http://www.bloodjournal.org/cgi/content/full/100/1/238/DC1/2
has_obo_namespace: mouse_pathology.ontology
id: MPATH:508

Axiom
annotated source: myeloid dysplasias
annotated property: definition
annotated target: Haematopoietic proliferation with evidence of trilineage dysplasia.
database_cross_reference: PMID:12070033

cytopenia with increased blasts
type: Class
subclass of: myeloid dysplasias
definition: Haematopoietic proliferation with evidence of trilineage dysplasia. More than 20% should be blasts.
database_cross_reference: URL:http://www.bloodjournal.org/cgi/content/full/100/1/238/DC1/2
has_obo_namespace: mouse_pathology.ontology
id: MPATH:509

Axiom
annotated source: cytopenia with increased blasts
annotated property: definition
annotated target: Haematopoietic proliferation with evidence of trilineage dysplasia. More than 20% should be blasts.
database_cross_reference: PMID:12070033

hypocalcification
type: Class
subclass of: intracellular and extracellular depletion
definition: Intrinsic abnormally low level of calcification in a tissue cf. MPATH: 48.
has_obo_namespace: mouse_pathology.ontology
id: MPATH:51

Axiom
annotated source: hypocalcification
annotated property: definition
annotated target: Intrinsic abnormally low level of calcification in a tissue cf. MPATH: 48.
database_cross_reference: Pathbase: Curation

myeloid proliferations (non-reactive)
type: Class
subclass of: non-Lymphoid neoplasias
definition: Non-reactive persistent accumulation of non-lymphoid haematopoietic cells. Genetically determined.
database_cross_reference: URL:http://www.bloodjournal.org/cgi/content/full/100/1/238/DC1/2
has_obo_namespace: mouse_pathology.ontology
id: MPATH:510

Axiom
annotated source: myeloid proliferations (non-reactive)
annotated property: definition
annotated target: Non-reactive persistent accumulation of non-lymphoid haematopoietic cells. Genetically determined.
database_cross_reference: PMID:12070033

myeloproliferation (genetic)
type: Class
subclass of: myeloid proliferations (non-reactive)
definition: Non-reactive persistent accumulation of non-lymphoid haematopoietic cells in the blood which do not infiltrate the spleen and the bone marrow. Genetically determined.
database_cross_reference: URL:http://www.bloodjournal.org/cgi/content/full/100/1/238/DC1/2
has_obo_namespace: mouse_pathology.ontology
id: MPATH:511

Axiom
annotated source: myeloproliferation (genetic)
annotated property: definition
annotated target: Non-reactive persistent accumulation of non-lymphoid haematopoietic cells in the blood which do not infiltrate the spleen and the bone marrow. Genetically determined.
database_cross_reference: PMID:12070033

myeloproliferative disease
type: Class
subclass of: myeloid proliferations (non-reactive)
definition: Non-reactive persistent accumulation of non-lymphoid haematopoietic cells in the blood which infiltrate the spleen and the bone marrow.
database_cross_reference: URL:http://www.bloodjournal.org/cgi/content/full/100/1/238/DC1/2
has_obo_namespace: mouse_pathology.ontology
id: MPATH:512

Axiom
annotated source: myeloproliferative disease
annotated property: definition
annotated target: Non-reactive persistent accumulation of non-lymphoid haematopoietic cells in the blood which infiltrate the spleen and the bone marrow.
database_cross_reference: PMID:12070033

lymphoid neoplasms
type: Class
subclass of: hematopoietic/lymphoid malignancies/disorder
definition: Neoplasms of the B or T cell lineage.
has_obo_namespace: mouse_pathology.ontology
id: MPATH:513

Axiom
annotated source: lymphoid neoplasms
annotated property: definition
annotated target: Neoplasms of the B or T cell lineage.
database_cross_reference: PMID:12070034

B cell neoplasms
type: Class
definition: B cell neoplasms
has_obo_namespace: mouse_pathology.ontology
id: MPATH:514
deprecated: true

Axiom
annotated source: B cell neoplasms
annotated property: definition
annotated target: B cell neoplasms
database_cross_reference: Pathbase: Pathology Committee

non-Lymphoid neoplasias
type: Class
subclass of: hematopoietic/lymphoid malignancies/disorder
definition: Hematological neoplasias of non-lymphoid origin.
database_cross_reference: URL:http://www.bloodjournal.org/cgi/content/full/100/1/238/DC1/2
has_obo_namespace: mouse_pathology.ontology
id: MPATH:515

Axiom
annotated source: non-Lymphoid neoplasias
annotated property: definition
annotated target: Hematological neoplasias of non-lymphoid origin.
database_cross_reference: PMID:12070033

B-cell neoplasms
type: Class
subclass of: lymphoid neoplasms
definition: Neoplasm of the B cell lymphoid lineage.
has_obo_namespace: mouse_pathology.ontology
id: MPATH:516

Axiom
annotated source: B-cell neoplasms
annotated property: definition
annotated target: Neoplasm of the B cell lymphoid lineage.
database_cross_reference: Pathbase: Curation

precursor B cell neoplasms
type: Class
subclass of: B-cell neoplasms
definition: Lymphoma originating from precursor B-cells.
has_obo_namespace: mouse_pathology.ontology
id: MPATH:517

Axiom
annotated source: precursor B cell neoplasms
annotated property: definition
annotated target: Lymphoma originating from precursor B-cells.
database_cross_reference: PMID:12070034

precursor B -cell lymphoblastic lymphoma/leukaemia
type: Class
subclass of: precursor B cell neoplasms
definition: Lymphoma originating in a precursor B-cell.
has_obo_namespace: mouse_pathology.ontology
has_related_synonym: lymphoblastic leukaemia
has_related_synonym: lymphoblastic lymphoma
id: MPATH:518

Axiom
annotated source: precursor B -cell lymphoblastic lymphoma/leukaemia
annotated property: definition
annotated target: Lymphoma originating in a precursor B-cell.
database_cross_reference: PMID:12070034

Axiom
annotated source: precursor B -cell lymphoblastic lymphoma/leukaemia
annotated property: has_related_synonym
annotated target: lymphoblastic leukaemia
database_cross_reference: Pathbase: Curation

Axiom
annotated source: precursor B -cell lymphoblastic lymphoma/leukaemia
annotated property: has_related_synonym
annotated target: lymphoblastic lymphoma
database_cross_reference: Pathbase: Curation

mature B-cell neoplasms
type: Class
subclass of: B-cell neoplasms
definition: Lymphomas originating in peripheral B cells.
has_obo_namespace: mouse_pathology.ontology
id: MPATH:519

Axiom
annotated source: mature B-cell neoplasms
annotated property: definition
annotated target: Lymphomas originating in peripheral B cells.
database_cross_reference: PMID:12070034

lipid depletion
type: Class
subclass of: intracellular and extracellular depletion
definition: Reduction in cellular or plasma lipid content.
has_obo_namespace: mouse_pathology.ontology
id: MPATH:52

Axiom
annotated source: lipid depletion
annotated property: definition
annotated target: Reduction in cellular or plasma lipid content.
database_cross_reference: Pathbase: Curation

small B-cell lymphoma
type: Class
subclass of: mature B-cell neoplasms
definition: Diffuse accumulation of small mature B-cells.
has_obo_namespace: mouse_pathology.ontology
has_related_synonym: small lymphocytic lymphoma
has_related_synonym: well differentiated lymphocytic lymphoma
id: MPATH:520

Axiom
annotated source: small B-cell lymphoma
annotated property: definition
annotated target: Diffuse accumulation of small mature B-cells.
database_cross_reference: Book: Morse; et al. (2002) Blood 100; 246-258

Axiom
annotated source: small B-cell lymphoma
annotated property: has_related_synonym
annotated target: small lymphocytic lymphoma
database_cross_reference: Pathbase: Curation

Axiom
annotated source: small B-cell lymphoma
annotated property: has_related_synonym
annotated target: well differentiated lymphocytic lymphoma
database_cross_reference: Pathbase: Curation

splenic marginal zone lymphoma
type: Class
subclass of: mature B-cell neoplasms
definition: A lymphoid proliferation of cells of the marginal zone of the white pulp of the spleen.
has_obo_namespace: mouse_pathology.ontology
has_related_synonym: SMZL
id: MPATH:521

Axiom
annotated source: splenic marginal zone lymphoma
annotated property: definition
annotated target: A lymphoid proliferation of cells of the marginal zone of the white pulp of the spleen.
database_cross_reference: PMID:12070034

Axiom
annotated source: splenic marginal zone lymphoma
annotated property: has_related_synonym
annotated target: SMZL
database_cross_reference: Pathbase: Curation

follicular B cell lymphoma
type: Class
subclass of: mature B-cell neoplasms
definition: A lymphoid proliferation composed of a mixture of centroblasts and centrocytes that may or may not have a nodular(follicular)pattern. The follicular dendritic cell network is not present, unlike in the human. The equivalent typical translocation (Chr. 14:18 )seen in humans has not been reported in the mouse.
has_obo_namespace: mouse_pathology.ontology
has_related_synonym: centroblastic/centrocytic lymphoma
has_related_synonym: follicular center cell lymphoma, small cell or mixed
has_related_synonym: follicular lymphoma
id: MPATH:522

Axiom
annotated source: follicular B cell lymphoma
annotated property: definition
annotated target: A lymphoid proliferation composed of a mixture of centroblasts and centrocytes that may or may not have a nodular(follicular)pattern. The follicular dendritic cell network is not present, unlike in the human. The equivalent typical translocation (Chr. 14:18 )seen in humans has not been reported in the mouse.
database_cross_reference: PMID:12070034

Axiom
annotated source: follicular B cell lymphoma
annotated property: has_related_synonym
annotated target: centroblastic/centrocytic lymphoma
database_cross_reference: Pathbase: Curation

Axiom
annotated source: follicular B cell lymphoma
annotated property: has_related_synonym
annotated target: follicular center cell lymphoma, small cell or mixed
database_cross_reference: Pathbase: Curation

Axiom
annotated source: follicular B cell lymphoma
annotated property: has_related_synonym
annotated target: follicular lymphoma
database_cross_reference: Pathbase: Curation

diffuse large B-cell lymphoma
type: Class
subclass of: mature B-cell neoplasms
definition: Diffuse proliferation of large B lymphoid cells.
has_obo_namespace: mouse_pathology.ontology
has_related_synonym: DLBCL
id: MPATH:523

Axiom
annotated source: diffuse large B-cell lymphoma
annotated property: definition
annotated target: Diffuse proliferation of large B lymphoid cells.
database_cross_reference: PMID:12070034

Axiom
annotated source: diffuse large B-cell lymphoma
annotated property: has_related_synonym
annotated target: DLBCL
database_cross_reference: Pathbase: Curation

diffuse large B-cell lymphoma, centroblastic type
type: Class
subclass of: diffuse large B-cell lymphoma
definition: Diffuse follicular centre cell lymphoma mainly composed of centroblasts.
has_obo_namespace: mouse_pathology.ontology
has_related_synonym: centroblastic lymphoma
id: MPATH:524

Axiom
annotated source: diffuse large B-cell lymphoma, centroblastic type
annotated property: definition
annotated target: Diffuse follicular centre cell lymphoma mainly composed of centroblasts.
database_cross_reference: PMID:12070034

Axiom
annotated source: diffuse large B-cell lymphoma, centroblastic type
annotated property: has_related_synonym
annotated target: centroblastic lymphoma
database_cross_reference: Pathbase: Curation

diffuse large B-cell lymphoma, immunoblastic type
type: Class
subclass of: diffuse large B-cell lymphoma
definition: Diffuse large B cell lymphoma with increased number of immunoblasts.
has_obo_namespace: mouse_pathology.ontology
has_related_synonym: Immunoblastic lymphoma
id: MPATH:525

Axiom
annotated source: diffuse large B-cell lymphoma, immunoblastic type
annotated property: definition
annotated target: Diffuse large B cell lymphoma with increased number of immunoblasts.
database_cross_reference: PMID:12070034

Axiom
annotated source: diffuse large B-cell lymphoma, immunoblastic type
annotated property: has_related_synonym
annotated target: Immunoblastic lymphoma
database_cross_reference: Pathbase: Curation

diffuse large B-cell lymphoma, histiocyte associated
type: Class
subclass of: diffuse large B-cell lymphoma
definition: Diffuse large B-cell lymphoma with more than 50% histiocytes.
has_obo_namespace: mouse_pathology.ontology
has_related_synonym: DLCL (HS)
id: MPATH:526

Axiom
annotated source: diffuse large B-cell lymphoma, histiocyte associated
annotated property: definition
annotated target: Diffuse large B-cell lymphoma with more than 50% histiocytes.
database_cross_reference: PMID:12070034

Axiom
annotated source: diffuse large B-cell lymphoma, histiocyte associated
annotated property: has_related_synonym
annotated target: DLCL (HS)
database_cross_reference: Pathbase: Curation

primary mediastinal (thymic) diffuse large B cell lymphoma
type: Class
subclass of: diffuse large B-cell lymphoma
definition: Primary B-cell lymphoma of the thymus. Reported in C57BL/6 mice infected with replication defective MuLV. Not clear that this is the equivalent of the human disease.
has_obo_namespace: mouse_pathology.ontology
id: MPATH:527

Axiom
annotated source: primary mediastinal (thymic) diffuse large B cell lymphoma
annotated property: definition
annotated target: Primary B-cell lymphoma of the thymus. Reported in C57BL/6 mice infected with replication defective MuLV. Not clear that this is the equivalent of the human disease.
database_cross_reference: PMID:12070034

classic Burkitt lymphoma
type: Class
subclass of: mature B-cell neoplasms
definition: Highly proliferative B-cell lymphoma characteristically seen in c-Myc transgenic mice, derived from mature B cells.
has_obo_namespace: mouse_pathology.ontology
id: MPATH:528

Axiom
annotated source: classic Burkitt lymphoma
annotated property: definition
annotated target: Highly proliferative B-cell lymphoma characteristically seen in c-Myc transgenic mice, derived from mature B cells.
database_cross_reference: PMID:12070034

Burkitt-like lymphoma
type: Class
subclass of: mature B-cell neoplasms
definition: Highly proliferative mature B-cell lymphoma, poorly defined.
has_obo_namespace: mouse_pathology.ontology
id: MPATH:529

Axiom
annotated source: Burkitt-like lymphoma
annotated property: definition
annotated target: Highly proliferative mature B-cell lymphoma, poorly defined.
database_cross_reference: PMID:12070034

osteopenia
type: Class
subclass of: intracellular and extracellular depletion
definition: Reduced bone mass due to inadequate synthesis of osteoid, resulting in decreased calcification.
has_obo_namespace: mouse_pathology.ontology
id: MPATH:53

Axiom
annotated source: osteopenia
annotated property: definition
annotated target: Reduced bone mass due to inadequate synthesis of osteoid, resulting in decreased calcification.
database_cross_reference: ISBN:0781727286

plasma cell neoplasms
type: Class
subclass of: B-cell neoplasms
definition: Diffuse proliferation of mature plasma cells. Clonal by definition. Includes the equivalent of human myeloma (ICD-O 9732/3).
database_cross_reference: URL: http://emice.nci.nih.gov/emice/mouse_models/organ_models/hema_models/hema_mouse_class
has_obo_namespace: mouse_pathology.ontology
has_related_synonym: Myeloma ( human )
id: MPATH:530

Axiom
annotated source: plasma cell neoplasms
annotated property: definition
annotated target: Diffuse proliferation of mature plasma cells. Clonal by definition. Includes the equivalent of human myeloma (ICD-O 9732/3).
database_cross_reference: PMID:12070034

Axiom
annotated source: plasma cell neoplasms
annotated property: has_related_synonym
annotated target: Myeloma ( human )
database_cross_reference: Pathbase: Curation

B-natural killer cell lymphoma
type: Class
subclass of: B-cell neoplasms
definition: Unusual lymphoma type described in thymectomised (SL/Kh x AKR/Ms) F1 mice. No equivalent found in human to date. See reference for detailed phenotype.
has_obo_namespace: mouse_pathology.ontology
id: MPATH:531

Axiom
annotated source: B-natural killer cell lymphoma
annotated property: definition
annotated target: Unusual lymphoma type described in thymectomised (SL/Kh x AKR/Ms) F1 mice. No equivalent found in human to date. See reference for detailed phenotype.
database_cross_reference: Lu; L-M.; et al (1999) Jpn J. Cancer Res. 90: 1218-1223

plasmacytoma
type: Class
subclass of: plasma cell neoplasms
definition: Diffuse proliferation of mature plasma cells. Clonal by definition.
database_cross_reference: URL: http://emice.nci.nih.gov/emice/mouse_models/organ_models/hema_models/hema_mouse_class
has_obo_namespace: mouse_pathology.ontology
id: MPATH:532
comment: Tissue, usually lymph nodes, that contain unusually large numbers of normal appearing plasma cells. While these may be plasmacytomas, additional work is needed to confirm this latter diagnosis.

Axiom
annotated source: plasmacytoma
annotated property: definition
annotated target: Diffuse proliferation of mature plasma cells. Clonal by definition.
database_cross_reference: PMID:12070034

extraosseous plasmacytoma
type: Class
subclass of: plasmacytoma
definition: Diffuse proliferation of mature plasma cells. Clonal by definition. Frequently found in IL6 transgenic mice. Characteristically involves spleen and nodes rather than peritoneum.
has_obo_namespace: mouse_pathology.ontology
id: MPATH:533

Axiom
annotated source: extraosseous plasmacytoma
annotated property: definition
annotated target: Diffuse proliferation of mature plasma cells. Clonal by definition. Frequently found in IL6 transgenic mice. Characteristically involves spleen and nodes rather than peritoneum.
database_cross_reference: PMID:12070034

anaplastic plasmacytoma
type: Class
subclass of: plasmacytoma
definition: Diffuse proliferation of immature plasma cells or plasma blasts.
has_obo_namespace: mouse_pathology.ontology
id: MPATH:534

Axiom
annotated source: anaplastic plasmacytoma
annotated property: definition
annotated target: Diffuse proliferation of immature plasma cells or plasma blasts.
database_cross_reference: PMID:12070034

T-cell neoplasms
type: Class
subclass of: lymphoid neoplasms
definition: Neoplasms derived from cells of the T lymphocyte lineage.
has_obo_namespace: mouse_pathology.ontology
id: MPATH:535

Axiom
annotated source: T-cell neoplasms
annotated property: definition
annotated target: Neoplasms derived from cells of the T lymphocyte lineage.
database_cross_reference: PMID:12070034

precursor T-cell neoplasms
type: Class
subclass of: T-cell neoplasms
definition: Neoplasms of precursor T cells.
has_obo_namespace: mouse_pathology.ontology
id: MPATH:536

Axiom
annotated source: precursor T-cell neoplasms
annotated property: definition
annotated target: Neoplasms of precursor T cells.
database_cross_reference: PMID:12070034

precursor T-cell lymphoblastic lymphoma/leukaemia
type: Class
subclass of: precursor T-cell neoplasms
definition: Precursor T cell derived neoplasia. Most commonly found in the thymus.
has_obo_namespace: mouse_pathology.ontology
has_related_synonym: thymic lymphoma
id: MPATH:537

Axiom
annotated source: precursor T-cell lymphoblastic lymphoma/leukaemia
annotated property: definition
annotated target: Precursor T cell derived neoplasia. Most commonly found in the thymus.
database_cross_reference: PMID:12070034

Axiom
annotated source: precursor T-cell lymphoblastic lymphoma/leukaemia
annotated property: has_related_synonym
annotated target: thymic lymphoma
database_cross_reference: Pathbase: Curation

mature T-cell neoplasms
type: Class
subclass of: T-cell neoplasms
definition: Non-thymic neoplasms of mature T cell origin.
has_obo_namespace: mouse_pathology.ontology
id: MPATH:538

Axiom
annotated source: mature T-cell neoplasms
annotated property: definition
annotated target: Non-thymic neoplasms of mature T cell origin.
database_cross_reference: PMID:12070034

small T-cell lymphoma
type: Class
subclass of: mature T-cell neoplasms
definition: Accumulation of small mature T cells. No human counterpart known to date.
has_obo_namespace: mouse_pathology.ontology
id: MPATH:539

Axiom
annotated source: small T-cell lymphoma
annotated property: definition
annotated target: Accumulation of small mature T cells. No human counterpart known to date.
database_cross_reference: PMID:12070034

osteoporosis
type: Class
subclass of: intracellular and extracellular depletion
definition: Reduction in the quantity of bone or atrophy of skeletal tissue. More severe than MPATH: 53 with gross changes to bone matrix.
has_obo_namespace: mouse_pathology.ontology
id: MPATH:54

Axiom
annotated source: osteoporosis
annotated property: definition
annotated target: Reduction in the quantity of bone or atrophy of skeletal tissue. More severe than MPATH: 53 with gross changes to bone matrix.
database_cross_reference: ISBN:0781727286

T cell neoplasms character undetermined
type: Class
subclass of: T-cell neoplasms
definition: T cell neoplasms which cannot currently be classified into known subtypes.
has_obo_namespace: mouse_pathology.ontology
id: MPATH:540

Axiom
annotated source: T cell neoplasms character undetermined
annotated property: definition
annotated target: T cell neoplasms which cannot currently be classified into known subtypes.
database_cross_reference: PMID:12070034

T large cell anaplastic lymphoma
type: Class
subclass of: T cell neoplasms character undetermined
definition: Diffuse large pleiomorphic T cell lymphoma. This entity does not correspond to human anaplastic large cell lymphoma.
has_obo_namespace: mouse_pathology.ontology
id: MPATH:541

Axiom
annotated source: T large cell anaplastic lymphoma
annotated property: definition
annotated target: Diffuse large pleiomorphic T cell lymphoma. This entity does not correspond to human anaplastic large cell lymphoma.
database_cross_reference: PMID:12070034

T natural killer cell lymphoma
type: Class
subclass of: T-cell neoplasms
definition: Neoplasm of large granular T cells of CD8 phenotype.
has_obo_namespace: mouse_pathology.ontology
id: MPATH:542

Axiom
annotated source: T natural killer cell lymphoma
annotated property: definition
annotated target: Neoplasm of large granular T cells of CD8 phenotype.
database_cross_reference: PMID:12070034

cholangioma
type: Class
subclass of: hepatic tumor
definition: Benign neoplasm of the biliary duct. Occurs in solid and cystic forms. (M-8160/0).
has_obo_namespace: mouse_pathology.ontology
id: MPATH:543

Axiom
annotated source: cholangioma
annotated property: definition
annotated target: Benign neoplasm of the biliary duct. Occurs in solid and cystic forms. (M-8160/0).
database_cross_reference: Pathbase: Pathology Committee

hepatocholangiocellular adenoma
type: Class
subclass of: complex tumor
subclass of: adenoma
subclass of: hepatic tumor
definition: Benign tumor of unknown origin showing features of hepatocelluar adenoma and cholangioma.
has_obo_namespace: mouse_pathology.ontology
id: MPATH:544

Axiom
annotated source: hepatocholangiocellular adenoma
annotated property: definition
annotated target: Benign tumor of unknown origin showing features of hepatocelluar adenoma and cholangioma.
database_cross_reference: Pathbase: Pathology Committee

hepatocholangiocellular carcinoma
type: Class
subclass of: complex tumor
subclass of: hepatic tumor
subclass of: carcinoma
definition: Malignant tumor of unknown origin showing features of hepatocelluar carcinoma and cholangiocarcinoma. (M-8180/3).
has_obo_namespace: mouse_pathology.ontology
id: MPATH:545

Axiom
annotated source: hepatocholangiocellular carcinoma
annotated property: definition
annotated target: Malignant tumor of unknown origin showing features of hepatocelluar carcinoma and cholangiocarcinoma. (M-8180/3).
database_cross_reference: Pathbase: Pathology Committee

blepharitis
type: Class
subclass of: inflammation
created by: George Gkoutos
creation date: 2011-03-22T03:07:49Z
has_obo_namespace: mouse_pathology.ontology
id: MPATH:546

mucous secretions
type: Class
subclass of: intracellular and extracellular accumulation
definition: Extracellular accumulation of mucous secretions.
has_obo_namespace: mouse_pathology.ontology
id: MPATH:547
comment: Mucus is the clear viscous secretion of the mucous membranes. Consisting of mucin, epithelial cells, leukocytes and various inorganic salts dissolved in water.

Axiom
annotated source: mucous secretions
annotated property: definition
annotated target: Extracellular accumulation of mucous secretions.
database_cross_reference: Pathbase: Pathology Committee

papillary transitional cell carcinoma
type: Class
subclass of: fibroepithelial tumor
subclass of: transitional cell tumor
definition: A generally malignant neoplasm consisting of villous or arborescent outgrowths of fibrovascular stroma covered by atypical neoplastic epithelial or urothelial cells cells.
has_obo_namespace: mouse_pathology.ontology
id: MPATH:548

Axiom
annotated source: papillary transitional cell carcinoma
annotated property: definition
annotated target: A generally malignant neoplasm consisting of villous or arborescent outgrowths of fibrovascular stroma covered by atypical neoplastic epithelial or urothelial cells cells.
database_cross_reference: Book: Kunze; E. (1994) Preneoplastic and neoplastic lesions of the Rat urinary bladder. In; Pathology of Neoplasia and Preneoplasia in Rodents. Eds. Bannach; P.; and Goessner; W.; Vol 1 p 114. Schattauer; Stuttgart New York

carcinoma
type: Class
subclass of: neoplasm
definition: Any of various types of malignant neoplasm derived from epithelial cells, chiefly glandular (adenocarcinoma) or squamous (squamous cell carcinoma).
has_obo_namespace: mouse_pathology.ontology
id: MPATH:549

Axiom
annotated source: carcinoma
annotated property: definition
annotated target: Any of various types of malignant neoplasm derived from epithelial cells, chiefly glandular (adenocarcinoma) or squamous (squamous cell carcinoma).
database_cross_reference: Pathbase: Curation

developmental and structural abnormality
type: Class
subclass of: pathological anatomical entity
definition: Developmental and structural abnormalities occurring during embryonic development or during adult life.
has_obo_namespace: mouse_pathology.ontology
id: MPATH:55

Axiom
annotated source: developmental and structural abnormality
annotated property: definition
annotated target: Developmental and structural abnormalities occurring during embryonic development or during adult life.
database_cross_reference: Pathbase: Pathology Committee

sarcoma
type: Class
definition: A connective tissue neoplasm, usually highly malignant, formed by proliferation of mesodermal cells.
has_obo_namespace: mouse_pathology.ontology
id: MPATH:550
deprecated: true

Axiom
annotated source: sarcoma
annotated property: definition
annotated target: A connective tissue neoplasm, usually highly malignant, formed by proliferation of mesodermal cells.
database_cross_reference: Pathbase: Pathology Committee

sarcoma
type: Class
subclass of: neoplasm
definition: A connective tissue neoplasm, usually highly malignant, formed by proliferation of mesodermal cells.
has_obo_namespace: mouse_pathology.ontology
id: MPATH:551

Axiom
annotated source: sarcoma
annotated property: definition
annotated target: A connective tissue neoplasm, usually highly malignant, formed by proliferation of mesodermal cells.
database_cross_reference: Pathbase: Curation

Clara cell adenoma
type: Class
definition: Benign tumor of the Clara cells of the bronchioalveolar epithelium.
database_cross_reference: URL: http://emice.nci.nih.gov/mouse_models/organ_models/lung_models/murinecancer/tumorclass
has_obo_namespace: mouse_pathology.ontology
id: MPATH:552
comment: Merged with MPATH:272 following recommendations of MMHC 2003.
deprecated: true

Axiom
annotated source: Clara cell adenoma
annotated property: definition
annotated target: Benign tumor of the Clara cells of the bronchioalveolar epithelium.
database_cross_reference: Book: Hahn; F.F. and Boorman; GA. neoplasia and pre-neoplasia in the lung. In Pathology of Neoplasia and Preneoplasia in Rodents. Vol.2. p 39. (1997) Schattauer ( Stuttgart and New York)

neuritis
type: Class
subclass of: inflammation
definition: Inflammation of a nerve.
has_obo_namespace: mouse_pathology.ontology
id: MPATH:553

Axiom
annotated source: neuritis
annotated property: definition
annotated target: Inflammation of a nerve.
database_cross_reference: ISBN:0781727286

dystrophy
type: Class
subclass of: process of degenerative change
definition: Regressive changes which may increase in severity, and which may result from defective nutrition or support of a tissue or organ.
has_obo_namespace: mouse_pathology.ontology
id: MPATH:554
comment: Most often used for diseases in which a structure does not develop properly (not necessarily in an embryonic context) and undergoes degradation.

Axiom
annotated source: dystrophy
annotated property: definition
annotated target: Regressive changes which may increase in severity, and which may result from defective nutrition or support of a tissue or organ.
database_cross_reference: Pathbase: Pathology Committee

mineralisation
type: Class
subclass of: intracellular and extracellular accumulation
definition: Deposition of any homogeneous inorganic material.
has_obo_namespace: mouse_pathology.ontology
id: MPATH:555

Axiom
annotated source: mineralisation
annotated property: definition
annotated target: Deposition of any homogeneous inorganic material.
database_cross_reference: ISBN:0781727286

potentially cancerous lesions
type: Class
subclass of: neoplasm
definition: Lesions which in some cases have the potential to become progressively growing malignant tumors.
has_obo_namespace: mouse_pathology.ontology
id: MPATH:556

Axiom
annotated source: potentially cancerous lesions
annotated property: definition
annotated target: Lesions which in some cases have the potential to become progressively growing malignant tumors.
database_cross_reference: Pathbase: Pathology Committee

aberrant crypt foci
type: Class
definition: Sensu gastrointsestinal tract. visible microscopically in whole mount colonic tissue. One or more crypts larger than most, have a thickened layer of epithelial cells that stain more intensely with methylene blue. Some have a slit shaped luminal opening, and increased pericryptal space and are elevated from the focal plane of the microscope. ACF is not a histologic diagnosis.
has_obo_namespace: mouse_pathology.ontology
has_related_synonym: ACF
id: MPATH:557
comment: Use IEN1 MPATH:130 instead. Suppressed as not strictly a histological diagnosis.
deprecated: true

Axiom
annotated source: aberrant crypt foci
annotated property: definition
annotated target: Sensu gastrointsestinal tract. visible microscopically in whole mount colonic tissue. One or more crypts larger than most, have a thickened layer of epithelial cells that stain more intensely with methylene blue. Some have a slit shaped luminal opening, and increased pericryptal space and are elevated from the focal plane of the microscope. ACF is not a histologic diagnosis.
database_cross_reference: PMID:12612914

Axiom
annotated source: aberrant crypt foci
annotated property: has_related_synonym
annotated target: ACF
database_cross_reference: Pathbase: Curation

adenomyoepithelioma
type: Class
subclass of: complex tumor
definition: Adenocarcinoma type tumor with both glandular and squamous differentiation. (M-8983/0).
has_obo_namespace: mouse_pathology.ontology
id: MPATH:558

Axiom
annotated source: adenomyoepithelioma
annotated property: definition
annotated target: Adenocarcinoma type tumor with both glandular and squamous differentiation. (M-8983/0).
database_cross_reference: PMID:10713680

acinar adenocarcinoma
type: Class
subclass of: adenocarcinoma
definition: Tumor composed of small glandular clusters with small lumens.
has_obo_namespace: mouse_pathology.ontology
id: MPATH:559

Axiom
annotated source: acinar adenocarcinoma
annotated property: definition
annotated target: Tumor composed of small glandular clusters with small lumens.
database_cross_reference: PMID:10713680

developmental or adult structural defect
type: Class
subclass of: developmental and structural abnormality
definition: Structural, physical or other general defect of prenatal development of the embryo and the placenta, or such as are acquired in the adult.
has_obo_namespace: mouse_pathology.ontology
id: MPATH:56

Axiom
annotated source: developmental or adult structural defect
annotated property: definition
annotated target: Structural, physical or other general defect of prenatal development of the embryo and the placenta, or such as are acquired in the adult.
database_cross_reference: Pathbase: Pathology Committee

cribriform adenocarcinoma
type: Class
subclass of: adenocarcinoma
definition: Tumor composed of sheets or nests of cells forming lumens with round, punched out spaces.
has_obo_namespace: mouse_pathology.ontology
id: MPATH:560

Axiom
annotated source: cribriform adenocarcinoma
annotated property: definition
annotated target: Tumor composed of sheets or nests of cells forming lumens with round, punched out spaces.
database_cross_reference: PMID:10713680

adenosquamous carcinoma
type: Class
subclass of: adenocarcinoma
subclass of: squamous cell tumor
definition: Mixed adeno- and squamous cell carcinoma. Not yet reported in mice. M-8560/3.
has_obo_namespace: mouse_pathology.ontology
id: MPATH:561

Axiom
annotated source: adenosquamous carcinoma
annotated property: definition
annotated target: Mixed adeno- and squamous cell carcinoma. Not yet reported in mice. M-8560/3.
database_cross_reference: PMID:12612914

torsion
type: Class
subclass of: developmental or adult structural defect
definition: The twisting of a bodily organ or part on its own axis.
has_obo_namespace: mouse_pathology.ontology
id: MPATH:562

Axiom
annotated source: torsion
annotated property: definition
annotated target: The twisting of a bodily organ or part on its own axis.
database_cross_reference: Pathbase: Pathology Committee

mucinous carcinoma
type: Class
subclass of: adenocarcinoma
definition: carcinoma derived from gastrointestinal epithelium with a high mucinous content. (M-8480/3).
has_obo_namespace: mouse_pathology.ontology
has_related_synonym: mucinous adenocarcinoma
id: MPATH:563

Axiom
annotated source: mucinous carcinoma
annotated property: definition
annotated target: carcinoma derived from gastrointestinal epithelium with a high mucinous content. (M-8480/3).
database_cross_reference: PMID:12612914

Axiom
annotated source: mucinous carcinoma
annotated property: has_related_synonym
annotated target: mucinous adenocarcinoma
database_cross_reference: Pathbase: Curation

glioblastoma
type: Class
subclass of: glioma
definition: Develop primarily through increasing anaplasia of well differentiated gliomas, mainly astrocytomas or oligodendrogliomas. Typically large and contain cells of different sizes with irrregular nuclei and atypical mitotic figures. (M-9440/3).
has_obo_namespace: mouse_pathology.ontology
has_related_synonym: glioblastoma multiforme
has_related_synonym: monstrocytoma
id: MPATH:564
comment: Also see Weiss, W.W, Israel, M. Cobbs, C., et al. (2002) Oncogene 21, 7453-7463.

Axiom
annotated source: glioblastoma
annotated property: definition
annotated target: Develop primarily through increasing anaplasia of well differentiated gliomas, mainly astrocytomas or oligodendrogliomas. Typically large and contain cells of different sizes with irrregular nuclei and atypical mitotic figures. (M-9440/3).
database_cross_reference: ISBN-13:9783794515530

Axiom
annotated source: glioblastoma
annotated property: has_related_synonym
annotated target: glioblastoma multiforme
database_cross_reference: Pathbase: Curation

Axiom
annotated source: glioblastoma
annotated property: has_related_synonym
annotated target: monstrocytoma
database_cross_reference: Pathbase: Curation

tumors of neurepithelial tissue
type: Class
subclass of: central nervous system tumor
definition: Tumors of neuronal and non-neuronal cells derived from embryonic neurepithelium.
has_obo_namespace: mouse_pathology.ontology
id: MPATH:565

Axiom
annotated source: tumors of neurepithelial tissue
annotated property: definition
annotated target: Tumors of neuronal and non-neuronal cells derived from embryonic neurepithelium.
database_cross_reference: Pathbase: Pathology Committee

tumors of the meninges
type: Class
subclass of: central nervous system tumor
definition: tumors of the meninges
has_obo_namespace: mouse_pathology.ontology
id: MPATH:566

Axiom
annotated source: tumors of the meninges
annotated property: definition
annotated target: tumors of the meninges
database_cross_reference: Pathbase: Curation

pilocytic astrocytoma
type: Class
subclass of: astrocytoma
definition: Glial cell derived tumor composed of bipolar cells with long `hairlike` GFAP-positive processes. (M9421/1).
has_obo_namespace: mouse_pathology.ontology
has_related_synonym: cystic cerebellar astrocytoma
id: MPATH:567
comment: Often cystic in children and generally considered benign.

Axiom
annotated source: pilocytic astrocytoma
annotated property: definition
annotated target: Glial cell derived tumor composed of bipolar cells with long `hairlike` GFAP-positive processes. (M9421/1).
database_cross_reference: Nervous System. Radovsky A and Mahler; J.S. In: Maronpot; R. Pathology of the Mouse. (1999) Cache River Press. Vienna IL

Axiom
annotated source: pilocytic astrocytoma
annotated property: has_related_synonym
annotated target: cystic cerebellar astrocytoma
database_cross_reference: Pathbase: Curation

mixed glioma
type: Class
subclass of: glioma
subclass of: complex tumor
definition: Mixed tumor containing astrocytes within an oligodendroglioma or vice versa. In some cases both components may be neoplastic. (M-9382/3).
has_obo_namespace: mouse_pathology.ontology
id: MPATH:568
comment: Also see Weiss, W.W, Israel, M. Cobbs, C., et al. (2002) Oncogene 21, 7453-7463.

Axiom
annotated source: mixed glioma
annotated property: definition
annotated target: Mixed tumor containing astrocytes within an oligodendroglioma or vice versa. In some cases both components may be neoplastic. (M-9382/3).
database_cross_reference: ISBN-13:9783794515530

granular cell tumor
type: Class
definition: granular cell tumor
has_obo_namespace: mouse_pathology.ontology
id: MPATH:569
comment: Subsumed into MP:413 as incidence in meninges, whilst a characteristic lesion, is the same type of tumor as that originally classified under myomatous tumors. Describe meningeal granular cell tumor using MP:413 and the anatomical descriptor.
deprecated: true

Axiom
annotated source: granular cell tumor
annotated property: definition
annotated target: granular cell tumor
database_cross_reference: ISBN-13:9783794515530

agenesis
type: Class
subclass of: developmental process abnormalities
definition: Failure of a tissue or organ to develop.
has_obo_namespace: mouse_pathology.ontology
has_related_synonym: Agenesia
id: MPATH:57

Axiom
annotated source: agenesis
annotated property: definition
annotated target: Failure of a tissue or organ to develop.
database_cross_reference: Pathbase: Pathology Committee

Axiom
annotated source: agenesis
annotated property: has_related_synonym
annotated target: Agenesia
database_cross_reference: Pathbase: Curation

peripheral nervous system tumors
type: Class
subclass of: neoplasm
definition: Tumors of the peripheral nervous system.
has_obo_namespace: mouse_pathology.ontology
id: MPATH:570

Axiom
annotated source: peripheral nervous system tumors
annotated property: definition
annotated target: Tumors of the peripheral nervous system.
database_cross_reference: Pathbase: Pathology Committee

pilomatricoma
type: Class
subclass of: basaloid follicular neoplasms
definition: Tumor composed of the epithelial components of the most proximal (trichogenic) portion of the hair follicle associated with an aberrent hair cortex type of cornification (ghost cells or shadow cells). The most primitive cellular component consists of basophilic cells having scanty cytoplasm and nuclei that occasionally overlap to some extent. In humans mineralisation is common.
has_obo_namespace: mouse_pathology.ontology
id: MPATH:571

Axiom
annotated source: pilomatricoma
annotated property: definition
annotated target: Tumor composed of the epithelial components of the most proximal (trichogenic) portion of the hair follicle associated with an aberrent hair cortex type of cornification (ghost cells or shadow cells). The most primitive cellular component consists of basophilic cells having scanty cytoplasm and nuclei that occasionally overlap to some extent. In humans mineralisation is common.
database_cross_reference: See: Gat; U.; DasGupta; R.; Degenstein; L. and Fuchs; E. (1998) De Novo hair follicle morphogenesis and hair tumors in mice expressing a truncated beta-catenin in skin Cell; 95; 605-614.

ossifying fibroma
type: Class
subclass of: osseous and chondromatous tumor
definition: Ossifying fibromas are benign tumors derived from pluripotential mesenchymal stem cells or osteoblasts. Occur spontaneously or in response to radiation. Preferentially located in mandible, maxilla and caudal spine. Composed of a characteristically regular trabecular bone pattern embedded in a fibrous stroma. Proliferating component consists of spindle cells which give rise to cuboidal osteoblasts to form rounded bodies or trabeculae. Bone trabeculae resemble the alphabet soup shapes characteristic of fibrous dysplasia in humans. In contrast to fibrous dysplasia the bone trabeculae of ossifying fibroma are mostly lamellar and ringed by active osteoblasts.
has_obo_namespace: mouse_pathology.ontology
id: MPATH:572

Axiom
annotated source: ossifying fibroma
annotated property: definition
annotated target: Ossifying fibromas are benign tumors derived from pluripotential mesenchymal stem cells or osteoblasts. Occur spontaneously or in response to radiation. Preferentially located in mandible, maxilla and caudal spine. Composed of a characteristically regular trabecular bone pattern embedded in a fibrous stroma. Proliferating component consists of spindle cells which give rise to cuboidal osteoblasts to form rounded bodies or trabeculae. Bone trabeculae resemble the alphabet soup shapes characteristic of fibrous dysplasia in humans. In contrast to fibrous dysplasia the bone trabeculae of ossifying fibroma are mostly lamellar and ringed by active osteoblasts.
database_cross_reference: Book: Luz A; Goessner; W.;and Murray AB.(1991) Ossifying fibroma; mouse. In; Jones TC; Mohr U; Hunt RD (eds) Monographs on pathology of laboratory animals. Cardiovascular and musculoskeletal systems. Springer; Berlin Heidelberg New York Tokyo; pp 228-232

inverted transitional cell papilloma
type: Class
subclass of: transitional cell papilloma
definition: Pre-malignant lesion of transitional cells, papillomatous form, in which proliferating epithelium is invaginated beneath the surface.
has_obo_namespace: mouse_pathology.ontology
id: MPATH:573

Axiom
annotated source: inverted transitional cell papilloma
annotated property: definition
annotated target: Pre-malignant lesion of transitional cells, papillomatous form, in which proliferating epithelium is invaginated beneath the surface.
database_cross_reference: Pathbase: Curation

nephroblastomatosis
type: Class
subclass of: developmental dysplasia
definition: Persistence of metanephrogenic blastema or its presence in the wrong place or at the wrong time. Associated with hyperplastic nephrogenic rests.
has_obo_namespace: mouse_pathology.ontology
id: MPATH:574

Axiom
annotated source: nephroblastomatosis
annotated property: definition
annotated target: Persistence of metanephrogenic blastema or its presence in the wrong place or at the wrong time. Associated with hyperplastic nephrogenic rests.
database_cross_reference: PMID:8383276

basaloid follicular neoplasms
type: Class
subclass of: adnexal and skin appendage tumor
definition: This is a new diagnostic term that the MMHC pathology panel felt best described a diagnostically challenging set of tumors that share the feature of being compose of basaloid cells showing follicular differentiation to some extent. These tumors are common in GEM involving the hedgehog signaling pathway and frequently have more than one of the histologic patterns listed below. The designation of benign and malignant has been excluded from the primary diagnosis purposely, as this is frequently difficult to determine in these characteristically well circumscribed tumors. The presence of a disorganized (non-palisaded) sheet-like growth pattern, tumor necrosis, or numerous mitoses are felt to represent malignant transformation.
has_obo_namespace: mouse_pathology.ontology
id: MPATH:575

Axiom
annotated source: basaloid follicular neoplasms
annotated property: definition
annotated target: This is a new diagnostic term that the MMHC pathology panel felt best described a diagnostically challenging set of tumors that share the feature of being compose of basaloid cells showing follicular differentiation to some extent. These tumors are common in GEM involving the hedgehog signaling pathway and frequently have more than one of the histologic patterns listed below. The designation of benign and malignant has been excluded from the primary diagnosis purposely, as this is frequently difficult to determine in these characteristically well circumscribed tumors. The presence of a disorganized (non-palisaded) sheet-like growth pattern, tumor necrosis, or numerous mitoses are felt to represent malignant transformation.
database_cross_reference: URL:http://emice.nci.nih.gov/emice/mouse_models/organ_models/skin_models

trichofolliculoma
type: Class
subclass of: basaloid follicular neoplasms
subclass of: Restriction
  on property: part of
  some values from: basaloid follicular neoplasms
definition: Basaloid neoplasm with numerous mature hair follicles and hair formation.
has_obo_namespace: mouse_pathology.ontology
id: MPATH:576

Axiom
annotated source: trichofolliculoma
annotated property: definition
annotated target: Basaloid neoplasm with numerous mature hair follicles and hair formation.
database_cross_reference: URL:http://emice.nci.nih.gov/emice/mouse_models/organ_models/skin_models

spiradenoma
type: Class
subclass of: basaloid follicular neoplasms
definition: Cellular neoplasm with well formed palisades of basaloid cells adjacent to less basophilic smaller cells with occasional central deposition of amorphous eosinophilic material. These tumors share some features with cylindroma type tumors but have a less well developed jigsaw puzzle-like architecture and tend to be more cellular.
has_obo_namespace: mouse_pathology.ontology
id: MPATH:577

Axiom
annotated source: spiradenoma
annotated property: definition
annotated target: Cellular neoplasm with well formed palisades of basaloid cells adjacent to less basophilic smaller cells with occasional central deposition of amorphous eosinophilic material. These tumors share some features with cylindroma type tumors but have a less well developed jigsaw puzzle-like architecture and tend to be more cellular.
database_cross_reference: URL:http://emice.nci.nih.gov/emice/mouse_models/organ_models/skin_models/hierarchical_classification

trichoblastoma
type: Class
subclass of: basaloid follicular neoplasms
definition: Basaloid neoplasm with frequent primitive hair follicles.
has_obo_namespace: mouse_pathology.ontology
id: MPATH:578

Axiom
annotated source: trichoblastoma
annotated property: definition
annotated target: Basaloid neoplasm with frequent primitive hair follicles.
database_cross_reference: URL:http://emice.nci.nih.gov/emice/mouse_models/organ_models/skin_models/hierarchical_classification

ulcer
type: Class
subclass of: cell and tissue damage
definition: Loss of epithelium and the basement membrane (full thickness). Cf Erosion.
has_obo_namespace: mouse_pathology.ontology
id: MPATH:579

Axiom
annotated source: ulcer
annotated property: definition
annotated target: Loss of epithelium and the basement membrane (full thickness). Cf Erosion.
database_cross_reference: Pathbase: Pathology Committee

aplasia
type: Class
subclass of: developmental process abnormalities
definition: Absence of an organ or tissue coupled with persistence of the organ/tissue primordium, which fails to develop completely.
has_obo_namespace: mouse_pathology.ontology
id: MPATH:58

Axiom
annotated source: aplasia
annotated property: definition
annotated target: Absence of an organ or tissue coupled with persistence of the organ/tissue primordium, which fails to develop completely.
database_cross_reference: ISBN:0781727286

erosion
type: Class
subclass of: general degenerative process
definition: Partial epithelial denudation not penetrating to the basement membrane.
has_obo_namespace: mouse_pathology.ontology
id: MPATH:580

Axiom
annotated source: erosion
annotated property: definition
annotated target: Partial epithelial denudation not penetrating to the basement membrane.
database_cross_reference: Pathbase: Pathology Committee

desmoplasia
type: Class
subclass of: defective growth and differentiation process
definition: Connective tissue proliferative reaction induced by a neoplastic process.
has_obo_namespace: mouse_pathology.ontology
has_related_synonym: scirrhous
has_related_synonym: sclerosis
id: MPATH:581

Axiom
annotated source: desmoplasia
annotated property: definition
annotated target: Connective tissue proliferative reaction induced by a neoplastic process.
database_cross_reference: Pathbase: Pathology Committee

Axiom
annotated source: desmoplasia
annotated property: has_related_synonym
annotated target: scirrhous
database_cross_reference: Pathbase: Curation

Axiom
annotated source: desmoplasia
annotated property: has_related_synonym
annotated target: sclerosis
database_cross_reference: Pathbase: Curation

cicatricial alopecia
type: Class
subclass of: alopecia
definition: Scarring of the hair follicle without affecting the adjacent dermis. Pigment may be associated with fibrous tract in pigmented individuals.
has_obo_namespace: mouse_pathology.ontology
id: MPATH:582

Axiom
annotated source: cicatricial alopecia
annotated property: definition
annotated target: Scarring of the hair follicle without affecting the adjacent dermis. Pigment may be associated with fibrous tract in pigmented individuals.
database_cross_reference: Pathbase: Curation

scarring alopecia
type: Class
subclass of: alopecia
definition: Loss of hair follicles in a diffuse dermal scar.
has_obo_namespace: mouse_pathology.ontology
id: MPATH:583

Axiom
annotated source: scarring alopecia
annotated property: definition
annotated target: Loss of hair follicles in a diffuse dermal scar.
database_cross_reference: Pathbase: Pathology Committee

myelofibrosis
type: Class
subclass of: tissue specific degenerative process
definition: In mice the term refers to accumulation of fibrous connective tissue in the medullary cavity of bones; usually in old mice. In humans the term is synonymous with myeloid metaplasia.
has_obo_namespace: mouse_pathology.ontology
id: MPATH:584

Axiom
annotated source: myelofibrosis
annotated property: definition
annotated target: In mice the term refers to accumulation of fibrous connective tissue in the medullary cavity of bones; usually in old mice. In humans the term is synonymous with myeloid metaplasia.
database_cross_reference: Pathbase: Pathology Committee

acidophilic macrophage pneumonia
type: Class
subclass of: pneumonia
definition: A mixed inflammatory infiltrate in the pulmonary airways with predominant intra-alveolar macrophage component with intra- and extracellular, elongated, bright eosinophilic/acidophilic crystals.
has_obo_namespace: mouse_pathology.ontology
id: MPATH:585
comment: Crystals and acidophilic material have been reported as various materials including Ym1 and Ym2 proteins and blood pigment derivatives and Eotaxin.

Axiom
annotated source: acidophilic macrophage pneumonia
annotated property: definition
annotated target: A mixed inflammatory infiltrate in the pulmonary airways with predominant intra-alveolar macrophage component with intra- and extracellular, elongated, bright eosinophilic/acidophilic crystals.
database_cross_reference: :Murray AB; Luz A ( 1990 ) Acidophilic macrophage pneumonia in laboratory mice. Vet Pathol. 27; 274-81

polycystic disease
type: Class
subclass of: tissue specific degenerative process
definition: A group of degenerative disorders resulting in multiple cysts in tissues.
has_obo_namespace: mouse_pathology.ontology
has_related_synonym: polycystic kidney disease
has_related_synonym: polycystic liver disease
has_related_synonym: polycystic ovary
id: MPATH:586

Axiom
annotated source: polycystic disease
annotated property: definition
annotated target: A group of degenerative disorders resulting in multiple cysts in tissues.
database_cross_reference: Pathbase: Pathology Committee

Axiom
annotated source: polycystic disease
annotated property: has_related_synonym
annotated target: polycystic kidney disease
database_cross_reference: Pathbase: Curation

Axiom
annotated source: polycystic disease
annotated property: has_related_synonym
annotated target: polycystic liver disease
database_cross_reference: Pathbase: Curation

Axiom
annotated source: polycystic disease
annotated property: has_related_synonym
annotated target: polycystic ovary
database_cross_reference: Pathbase: Curation

Cribriform epididymal hyperplasia
type: Class
subclass of: hyperplastic tissue
definition: The lesion is characterized microscopically by epithelial cells with atypical hyperchromatic nuclei, vacuolization, intratubular lumina formation, infrequent apoptosis, and rare mitotic figures. In contrast to germ cells, the cells of CEH do not express alpha-fetoprotein, carcinoembryonic antigen, or S-100. Ultrastructurally, the cells are pleomorphic with stereocilia at their apical borders and within intratubular lumina, and are supported by a basement membrane. CEH does not appear to be a preneoplastic change.
has_obo_namespace: mouse_pathology.ontology
id: MPATH:587
comment: Cribriform epididymal hyperplasia was initially described as an incidental finding in human orchidectomy specimens. Recently, this condition was also described in mice, homozygous for a targeted mutation in p53.

Axiom
annotated source: Cribriform epididymal hyperplasia
annotated property: definition
annotated target: The lesion is characterized microscopically by epithelial cells with atypical hyperchromatic nuclei, vacuolization, intratubular lumina formation, infrequent apoptosis, and rare mitotic figures. In contrast to germ cells, the cells of CEH do not express alpha-fetoprotein, carcinoembryonic antigen, or S-100. Ultrastructurally, the cells are pleomorphic with stereocilia at their apical borders and within intratubular lumina, and are supported by a basement membrane. CEH does not appear to be a preneoplastic change.
database_cross_reference: Journal: La Perle KM; Blomme EA; Sagartz JE; Capen CC (2002) Epididymal cribriform hyperplasia with nuclear atypia in p53 homozygous knockout. Comp Med. 2002 52:568-71.

dysplasia
type: Class
definition: Dysplasia
has_obo_namespace: mouse_pathology.ontology
id: MPATH:588
deprecated: true

Axiom
annotated source: dysplasia
annotated property: definition
annotated target: Dysplasia
database_cross_reference: Pathbase: Pathology Committee

dysplasia
type: Class
subclass of: defective growth and differentiation process
definition: Distortion or deficiency of the tissue or cellular architecture.
has_obo_namespace: mouse_pathology.ontology
id: MPATH:589
comment: Note that with respect to developmental processes the term dysplasia is often used with greater specificity to describe aberrant developmental processes of proliferation and differentation, in which case MPATH: 64 Developmental dysplasia should be used.

Axiom
annotated source: dysplasia
annotated property: definition
annotated target: Distortion or deficiency of the tissue or cellular architecture.
database_cross_reference: Pathbase: Pathology Committee

defective branching morphogenesis
type: Class
subclass of: developmental process abnormalities
definition: Defect in the process determining number, angle, pattern or rate of branching of tubular branched structures eg. Glandular ducts.
has_obo_namespace: mouse_pathology.ontology
id: MPATH:59

Axiom
annotated source: defective branching morphogenesis
annotated property: definition
annotated target: Defect in the process determining number, angle, pattern or rate of branching of tubular branched structures eg. Glandular ducts.
database_cross_reference: Pathbase: Pathology Committee

fibro-osseous lesion
type: Class
subclass of: dysplasia
definition: Lesion of bone showing accelerated osteoclastic bone resorption coupled with fibroplasia. Later stages show proliferation of osteoblasts.
has_obo_namespace: mouse_pathology.ontology
has_related_synonym: fibrous dysplasia
has_related_synonym: fibrous osteodystrophy
has_related_synonym: osteodysplasia
has_related_synonym: osteodystrophy
has_related_synonym: osteofibrosis
id: MPATH:590
comment: The benign fibro-osseous lesions (BFOL) represent a clinically diverse group of disorders of bone that share similar histopathologic features. As a group, they are relatively common in the craniofacial complex, especially the jaws. Common in some inbred strains notably B6C3F1 females. Note that many of the synonyms have been used historically and may not be accurate. See: Albassam MA, Courtney CL (1996) Nonneoplastic and neoplastic lesions of the bone. In: Mohr U, Dungworth DL, Capen CC, Carlton WW, Sundberg JP, Ward JM (eds) Pathobiology of the aging mouse. Vol 2. Musculoskeletal system. ILSI Press, Washington D.C., pp 425-437. AND Albassam MA, Wojcinski ZW, Barsoum NJ, Smith, GS (1991) Spontaneous fibro-osseous proliferative lesions in the sternums and femurs of B6C3F1 mice. Vet Path 28: 381-388.

Axiom
annotated source: fibro-osseous lesion
annotated property: definition
annotated target: Lesion of bone showing accelerated osteoclastic bone resorption coupled with fibroplasia. Later stages show proliferation of osteoblasts.
database_cross_reference: Book: Albassam MA; Courtney CL (1996) Nonneoplastic and neoplastic lesions of the bone. In; Mohr U; Dungworth DL; Capen CC; Carlton WW; Sundberg JP; Ward JM (eds) Pathobiology of the aging mouse. Vol 2. Musculoskeletal system. ILSI Press; Washington D.C.; pp 425-437

Axiom
annotated source: fibro-osseous lesion
annotated property: has_related_synonym
annotated target: fibrous dysplasia
database_cross_reference: Pathbase: Curation

Axiom
annotated source: fibro-osseous lesion
annotated property: has_related_synonym
annotated target: fibrous osteodystrophy
database_cross_reference: Pathbase: Curation

Axiom
annotated source: fibro-osseous lesion
annotated property: has_related_synonym
annotated target: osteodysplasia
database_cross_reference: Pathbase: Curation

Axiom
annotated source: fibro-osseous lesion
annotated property: has_related_synonym
annotated target: osteodystrophy
database_cross_reference: Pathbase: Curation

Axiom
annotated source: fibro-osseous lesion
annotated property: has_related_synonym
annotated target: osteofibrosis
database_cross_reference: Pathbase: Curation

fatty infiltration
type: Class
subclass of: healing and repair structure
definition: Accumulation of mature adipose tissue in a healing wound site or otherwise in response to tissue damage.
has_obo_namespace: mouse_pathology.ontology
id: MPATH:591

Axiom
annotated source: fatty infiltration
annotated property: definition
annotated target: Accumulation of mature adipose tissue in a healing wound site or otherwise in response to tissue damage.
database_cross_reference: Pathbase: Pathology Committee

osteopetrosis
type: Class
subclass of: dysplasia
definition: Excessive formation of dense trabecular bone and mineralized cartilage, especially in long bones, leading to obliteration of marrow spaces and to anemia with myeloid metaplasia and hepatosplenomegaly beginning in infancy, to bone fragility, and to progressive deafness and blindness.
has_obo_namespace: mouse_pathology.ontology
has_related_synonym: Albers-Schoenberg disease
has_related_synonym: marble bone disease
has_related_synonym: marble bones
id: MPATH:592

Axiom
annotated source: osteopetrosis
annotated property: definition
annotated target: Excessive formation of dense trabecular bone and mineralized cartilage, especially in long bones, leading to obliteration of marrow spaces and to anemia with myeloid metaplasia and hepatosplenomegaly beginning in infancy, to bone fragility, and to progressive deafness and blindness.
database_cross_reference: PMID:15625335

Axiom
annotated source: osteopetrosis
annotated property: has_related_synonym
annotated target: Albers-Schoenberg disease
database_cross_reference: Pathbase: Curation

Axiom
annotated source: osteopetrosis
annotated property: has_related_synonym
annotated target: marble bone disease
database_cross_reference: Pathbase: Curation

Axiom
annotated source: osteopetrosis
annotated property: has_related_synonym
annotated target: marble bones
database_cross_reference: Pathbase: Curation

myeloma
type: Class
definition: Plasma cell myeloma - (ICD-O 9732/3).
has_obo_namespace: mouse_pathology.ontology
id: MPATH:593
deprecated: true

Axiom
annotated source: myeloma
annotated property: definition
annotated target: Plasma cell myeloma - (ICD-O 9732/3).
database_cross_reference: Pathbase: Pathology Committee

cystic hyperplasia
type: Class
subclass of: epithelial and stromal hyperplasia
definition: Formation of multiple retention cysts from obstruction of ducts or glands by hyperplasia of the lining epithelium.
has_obo_namespace: mouse_pathology.ontology
id: MPATH:594

Axiom
annotated source: cystic hyperplasia
annotated property: definition
annotated target: Formation of multiple retention cysts from obstruction of ducts or glands by hyperplasia of the lining epithelium.
database_cross_reference: Pathbase: Pathology Committee

extramedullary hemopoiesis
type: Class
subclass of: non-Lymphoid neoplasias
definition: The formation of and development of blood cells outside the red pulp of the spleen. Composed of varying numbers of megakaryocytes as well as myeloid and erythroid precursors.
has_obo_namespace: mouse_pathology.ontology
id: MPATH:595
comment: Production of blood cells in tissues other than the bone marrow. In the mouse, this is usually the liver.

Axiom
annotated source: extramedullary hemopoiesis
annotated property: definition
annotated target: The formation of and development of blood cells outside the red pulp of the spleen. Composed of varying numbers of megakaryocytes as well as myeloid and erythroid precursors.
database_cross_reference: :Ward; J.M.; Mann; P.C.; Mrishima; H.; and Frith; C.H. Thymus; Spleen and Lymph nodes. Ch 13. p342. In Maronpot; R. Pathology of the Mouse. (1999) Cache River Press. Vienna IL

pathological process
type: Class
subclass of: pathological entity
definition: The organic response of tissues to external insult, injury or underlying genetic or epigenetic lesion.
has_obo_namespace: mouse_pathology.ontology
id: MPATH:596

Axiom
annotated source: pathological process
annotated property: definition
annotated target: The organic response of tissues to external insult, injury or underlying genetic or epigenetic lesion.
database_cross_reference: Pathbase: Pathology Committee

cell and tissue damage process
type: Class
subclass of: pathological process
definition: Processes occurring during cell and tissue damage of either intrinsic or extrinsic etiology.
has_obo_namespace: mouse_pathology.ontology
id: MPATH:597

Axiom
annotated source: cell and tissue damage process
annotated property: definition
annotated target: Processes occurring during cell and tissue damage of either intrinsic or extrinsic etiology.
database_cross_reference: Pathbase: Pathology Committee

degenerative entity
type: Class
definition: degenerative entity
has_obo_namespace: mouse_pathology.ontology
id: MPATH:598
deprecated: true

Axiom
annotated source: degenerative entity
annotated property: definition
annotated target: degenerative entity
database_cross_reference: Pathbase: Pathology Committee

developmental process abnormalities
type: Class
subclass of: pathological process
definition: developmental process abnormalities
has_obo_namespace: mouse_pathology.ontology
id: MPATH:599

Axiom
annotated source: developmental process abnormalities
annotated property: definition
annotated target: developmental process abnormalities
database_cross_reference: Pathbase: Pathology Committee

caseous necrosis
type: Class
subclass of: necrosis
definition: Necrosis characteristic of some inflammatory conditions which represents necrosis with loss of structure of the various cellular and tissue elements; affected tissue manifests a friable, crumbly consistency.
has_obo_namespace: mouse_pathology.ontology
id: MPATH:6

Axiom
annotated source: caseous necrosis
annotated property: definition
annotated target: Necrosis characteristic of some inflammatory conditions which represents necrosis with loss of structure of the various cellular and tissue elements; affected tissue manifests a friable, crumbly consistency.
database_cross_reference: ISBN:0781727286

communication defect
type: Class
subclass of: developmental or adult structural defect
definition: Failure of two cavities, voids or lumens to connect.
has_obo_namespace: mouse_pathology.ontology
id: MPATH:60

Axiom
annotated source: communication defect
annotated property: definition
annotated target: Failure of two cavities, voids or lumens to connect.
database_cross_reference: Pathbase: Curation

branching defect
type: Class
subclass of: developmental or adult structural defect
definition: Aberrant branch or branching pattern of a branched structure such as the bronchus.
has_obo_namespace: mouse_pathology.ontology
id: MPATH:600

Axiom
annotated source: branching defect
annotated property: definition
annotated target: Aberrant branch or branching pattern of a branched structure such as the bronchus.
database_cross_reference: Pathbase: Curation

developmental hypertrophy
type: Class
subclass of: developmental process abnormalities
definition: Increase of the size or cellularity of an organ or tissue as a consequence of loss of normal regulation of cell proliferation.
has_obo_namespace: mouse_pathology.ontology
id: MPATH:601

Axiom
annotated source: developmental hypertrophy
annotated property: definition
annotated target: Increase of the size or cellularity of an organ or tissue as a consequence of loss of normal regulation of cell proliferation.
database_cross_reference: Pathbase: Pathology Committee

hyperplastic tissue
type: Class
subclass of: growth and differentiation defect
definition: An organ or a tissue with an abnormal increase in the number of cells as a consequence of cell proliferation.
has_obo_namespace: mouse_pathology.ontology
id: MPATH:602

Axiom
annotated source: hyperplastic tissue
annotated property: definition
annotated target: An organ or a tissue with an abnormal increase in the number of cells as a consequence of cell proliferation.
database_cross_reference: Pathbase: Pathology Committee

pathological anatomical entity
type: Class
subclass of: pathological entity
definition: Anatomically located instance of pathological response or entity.
has_obo_namespace: mouse_pathology.ontology
id: MPATH:603

Axiom
annotated source: pathological anatomical entity
annotated property: definition
annotated target: Anatomically located instance of pathological response or entity.
database_cross_reference: Pathbase: Pathology Committee

defective growth and differentiation process
type: Class
subclass of: pathological process
definition: Abnormal increase or decrease in the rate of cell growth or cell division including associated changes in the differentiation state of adult cells.
has_obo_namespace: mouse_pathology.ontology
id: MPATH:604
comment: Excludes abnormalities of developmental proliferation and differentiation.

Axiom
annotated source: defective growth and differentiation process
annotated property: definition
annotated target: Abnormal increase or decrease in the rate of cell growth or cell division including associated changes in the differentiation state of adult cells.
database_cross_reference: Pathbase: Pathology Committee

metaplastic tissue
type: Class
subclass of: growth and differentiation defect
definition: A tissue or group of cells in which there has been abnormal transformation of an fully differentiated adult cell or tissue of one kind into a differentiated tissue of another kind.
has_obo_namespace: mouse_pathology.ontology
id: MPATH:605
comment: Nearly exclusively used in an adult context.

Axiom
annotated source: metaplastic tissue
annotated property: definition
annotated target: A tissue or group of cells in which there has been abnormal transformation of an fully differentiated adult cell or tissue of one kind into a differentiated tissue of another kind.
database_cross_reference: Pathbase: Pathology Committee

neoplasia
type: Class
subclass of: pathological process
definition: The pathological process that results in the formation and growth of a neoplasm.
has_obo_namespace: mouse_pathology.ontology
has_related_synonym: neoplastic process
id: MPATH:606
comment: Literally: new growth of cells. Neoplasia refers to the unscheduled or abnormal growth of cells, potentially resulting in a benign or malignant tumour. Neoplasms include potentially cancerous lesions as well as full malignancies but not all neoplasms are potentially cancerous.

Axiom
annotated source: neoplasia
annotated property: definition
annotated target: The pathological process that results in the formation and growth of a neoplasm.
database_cross_reference: Pathbase: Pathology Committee

Axiom
annotated source: neoplasia
annotated property: has_related_synonym
annotated target: neoplastic process
database_cross_reference: Pathbase: Curation

healing and repair structure
type: Class
subclass of: pathological anatomical entity
definition: Physical entity or structure associated with normal or abnormal tissue healing or repair following extrinsic or intrinsic damage.
has_obo_namespace: mouse_pathology.ontology
id: MPATH:607

Axiom
annotated source: healing and repair structure
annotated property: definition
annotated target: Physical entity or structure associated with normal or abnormal tissue healing or repair following extrinsic or intrinsic damage.
database_cross_reference: Pathbase: Pathology Committee

abscess
type: Class
subclass of: healing and repair structure
definition: A circumscribed collection of purulent exudate frequently associated with swelling and other signs of inflammation.
has_obo_namespace: mouse_pathology.ontology
id: MPATH:608
comment: Generally occur following damage or infection with subsequent inflammatory response. Result of the body`s defensive reaction to foreign material.

Axiom
annotated source: abscess
annotated property: definition
annotated target: A circumscribed collection of purulent exudate frequently associated with swelling and other signs of inflammation.
database_cross_reference: ISBN:0781727286

empyema
type: Class
subclass of: healing and repair structure
definition: Pus in a body cavity; when used without qualification, refers specifically to pyothorax.
has_obo_namespace: mouse_pathology.ontology
id: MPATH:609

Axiom
annotated source: empyema
annotated property: definition
annotated target: Pus in a body cavity; when used without qualification, refers specifically to pyothorax.
database_cross_reference: ISBN:0781727286

curvature defect
type: Class
subclass of: developmental or adult structural defect
definition: Inappropriate curvature of a structure.
has_obo_namespace: mouse_pathology.ontology
id: MPATH:61

Axiom
annotated source: curvature defect
annotated property: definition
annotated target: Inappropriate curvature of a structure.
database_cross_reference: Pathbase: Curation

angiectasia
type: Class
subclass of: ectasia
definition: Dilatation of a blood vessel or valve.
has_obo_namespace: mouse_pathology.ontology
id: MPATH:610

Axiom
annotated source: angiectasia
annotated property: definition
annotated target: Dilatation of a blood vessel or valve.
database_cross_reference: ISBN:0781727286

glossitis
type: Class
subclass of: inflammation
definition: Acute or chronic inflammation of the tongue.
has_obo_namespace: mouse_pathology.ontology
id: MPATH:611

Axiom
annotated source: glossitis
annotated property: definition
annotated target: Acute or chronic inflammation of the tongue.
database_cross_reference: Pathbase: Pathology Committee

Abscess
type: Class
definition: A circumscribed collection of purulent exudate frequently associated with swelling and other signs of inflammation.
has_obo_namespace: mouse_pathology.ontology
id: MPATH:612
comment: Alternately a cavity formed by liquefactive necrosis within solid tissue. Obsoleted by MPATH 608
deprecated: true

Axiom
annotated source: Abscess
annotated property: definition
annotated target: A circumscribed collection of purulent exudate frequently associated with swelling and other signs of inflammation.
database_cross_reference: ISBN:0781727286

pigmentation
type: Class
subclass of: intracellular and extracellular accumulation
definition: Coloration, either normal or pathologic, of the skin or tissues resulting from a deposit of pigment.
has_obo_namespace: mouse_pathology.ontology
id: MPATH:613

Axiom
annotated source: pigmentation
annotated property: definition
annotated target: Coloration, either normal or pathologic, of the skin or tissues resulting from a deposit of pigment.
database_cross_reference: ISBN:0781727286

concretion
type: Class
subclass of: intracellular and extracellular accumulation
definition: Solid material formed by aggregation of discrete units or particles.
has_obo_namespace: mouse_pathology.ontology
id: MPATH:614

Axiom
annotated source: concretion
annotated property: definition
annotated target: Solid material formed by aggregation of discrete units or particles.
database_cross_reference: ISBN:0781727286

cardiomyopathy
type: Class
subclass of: tissue specific degenerative process
definition: A disease of the heart muscle or myocardium proper.
has_obo_namespace: mouse_pathology.ontology
id: MPATH:615
comment: Cardiomyopathies may be classified as either primary or secondary, on the basis of etiology, or on the pathophysiology of the lesion: hypertrophic, dilated, or restrictive.

Axiom
annotated source: cardiomyopathy
annotated property: definition
annotated target: A disease of the heart muscle or myocardium proper.
database_cross_reference: :NCI Thesaurus / A7567983

hyperostosis
type: Class
subclass of: hypertrophy
definition: Hypertrophy of bone characterised by an abnormal increase in non-neoplastic skeletal bone mass. These may be proliferative or non-proliferative lesions.
has_obo_namespace: mouse_pathology.ontology
has_related_synonym: osteosclerosis
id: MPATH:616

Axiom
annotated source: hyperostosis
annotated property: definition
annotated target: Hypertrophy of bone characterised by an abnormal increase in non-neoplastic skeletal bone mass. These may be proliferative or non-proliferative lesions.
database_cross_reference: Long; P.H.; and Leininger; J.R ( 1999) Bones Joints and synovia; p663. in: Pathology of the Mouse. Ed Maronpot; R. Cache River Press

Axiom
annotated source: hyperostosis
annotated property: has_related_synonym
annotated target: osteosclerosis
database_cross_reference: Pathbase: Curation

focus of cellular alteration
type: Class
subclass of: potentially cancerous lesions
definition: Focal lesions of hepatocytes characterised primarily by altered cytoplasmic tinctorial properties. Classified as basophilic, eosinophilic, clear cell or mixed type.
has_obo_namespace: mouse_pathology.ontology
has_related_synonym: Areas of cellular alteration
has_related_synonym: Enzyme altered focus
has_related_synonym: Focus of altered hepatocytes (fah)
has_related_synonym: Hyperplastic focus
has_related_synonym: Phenotypically altered focus
has_related_synonym: Preneoplastic focus
id: MPATH:617
comment: More recently amphophilic cell foci, diffusely basophilic cell foci and vacuolated cell foci have been described.

Axiom
annotated source: focus of cellular alteration
annotated property: definition
annotated target: Focal lesions of hepatocytes characterised primarily by altered cytoplasmic tinctorial properties. Classified as basophilic, eosinophilic, clear cell or mixed type.
database_cross_reference: Pathbase: Mohr

Axiom
annotated source: focus of cellular alteration
annotated property: has_related_synonym
annotated target: Areas of cellular alteration
database_cross_reference: Pathbase: Curation

Axiom
annotated source: focus of cellular alteration
annotated property: has_related_synonym
annotated target: Enzyme altered focus
database_cross_reference: Pathbase: Curation

Axiom
annotated source: focus of cellular alteration
annotated property: has_related_synonym
annotated target: Focus of altered hepatocytes (fah)
database_cross_reference: Pathbase: Curation

Axiom
annotated source: focus of cellular alteration
annotated property: has_related_synonym
annotated target: Hyperplastic focus
database_cross_reference: Pathbase: Curation

Axiom
annotated source: focus of cellular alteration
annotated property: has_related_synonym
annotated target: Phenotypically altered focus
database_cross_reference: Pathbase: Curation

Axiom
annotated source: focus of cellular alteration
annotated property: has_related_synonym
annotated target: Preneoplastic focus
database_cross_reference: Pathbase: Curation

myeloid hyperplasia
type: Class
subclass of: non-Lymphoid neoplasias
definition: Hyperplasia of myeloid lineage, usually in the spleen.
has_obo_namespace: mouse_pathology.ontology
id: MPATH:618
comment: Myeloid hyperplasia ia a common diagnosis in mouse spleen. In the normal mouse spleen, a low degree of production of myeloid cells occurs (neutrophils, erythroid cells and megakaryocytes). Commonly in aging mice, due to tumors and inflammatory lesions, the mouse myeloid system in bone marrow and spleen react and become hyperplastic. In the spleen it is diagnosed as "myeloid hyperplasia" (MH), in the past it was often extramedullary hematopoiesis, which is still used by some but it is normal to a low degree in normal mouse spleen.

Axiom
annotated source: myeloid hyperplasia
annotated property: definition
annotated target: Hyperplasia of myeloid lineage, usually in the spleen.
database_cross_reference: Pathbase: Pathology Committee

truncoconal septal defect
type: Class
subclass of: cardiac septation defect
definition: Septal defect lying between the aorta and pulmonary trunks caused by failure of the spiral septum to separate the truncus arteriosus.
has_obo_namespace: mouse_pathology.ontology
id: MPATH:619

Axiom
annotated source: truncoconal septal defect
annotated property: definition
annotated target: Septal defect lying between the aorta and pulmonary trunks caused by failure of the spiral septum to separate the truncus arteriosus.
database_cross_reference: Pathbase: Pathology Committee

cyst
type: Class
subclass of: developmental or adult structural defect
definition: Formation of an epithelium bounded cavity not associated with neoplasia.
has_obo_namespace: mouse_pathology.ontology
id: MPATH:62

Axiom
annotated source: cyst
annotated property: definition
annotated target: Formation of an epithelium bounded cavity not associated with neoplasia.
database_cross_reference: Pathbase: Pathology Committee

inter-atrial septal defect
type: Class
subclass of: cardiac septation defect
definition: Incomplete closure of the inter-atrial septum due to failure of the primary or secondary septum.
has_obo_namespace: mouse_pathology.ontology
id: MPATH:620

Axiom
annotated source: inter-atrial septal defect
annotated property: definition
annotated target: Incomplete closure of the inter-atrial septum due to failure of the primary or secondary septum.
database_cross_reference: Pathbase: Curation

inter-ventricular septal defect
type: Class
subclass of: cardiac septation defect
definition: Failure of the inter-ventricular septum to completely close between the left and right ventricles.
has_obo_namespace: mouse_pathology.ontology
id: MPATH:621

Axiom
annotated source: inter-ventricular septal defect
annotated property: definition
annotated target: Failure of the inter-ventricular septum to completely close between the left and right ventricles.
database_cross_reference: Pathbase: Curation

steatosis
type: Class
subclass of: intracellular and extracellular accumulation
definition: Abnormal retention of lipids within a cell. Physically apparent as lipid within liposomes of parenchymal cells.
has_exact_synonym: lipidosis
has_obo_namespace: mouse_pathology.ontology
has_related_synonym: adipose degeneration
has_related_synonym: fatty change
has_related_synonym: fatty degeneration
id: MPATH:622
comment: Most commonly associated with degenerative change in the liver.

Axiom
annotated source: steatosis
annotated property: definition
annotated target: Abnormal retention of lipids within a cell. Physically apparent as lipid within liposomes of parenchymal cells.
database_cross_reference: Pathbase: Curation

Axiom
annotated source: steatosis
annotated property: has_related_synonym
annotated target: adipose degeneration
database_cross_reference: Pathbase: Curation

Axiom
annotated source: steatosis
annotated property: has_related_synonym
annotated target: fatty change
database_cross_reference: Pathbase: Curation

Axiom
annotated source: steatosis
annotated property: has_related_synonym
annotated target: fatty degeneration
database_cross_reference: Pathbase: Curation

synechia
type: Class
subclass of: developmental or adult structural defect
definition: An adhesion, usually between the iris and the cornea or the lens capsule.
has_obo_namespace: mouse_pathology.ontology
id: MPATH:623
comment: May also be seen in the uterus ( in humans Asherman`s syndrome).

Axiom
annotated source: synechia
annotated property: definition
annotated target: An adhesion, usually between the iris and the cornea or the lens capsule.
database_cross_reference: Millodot; Michel and Daniel Laby. Dictionary of Ophthalmology. London: Butterworth Heinemann; 2002

involution
type: Class
subclass of: developmental or adult structural defect
definition: Turning in of the edges of a structure.
has_obo_namespace: mouse_pathology.ontology
id: MPATH:624
comment: Not return of an enlarged organ to its normal size.

Axiom
annotated source: involution
annotated property: definition
annotated target: Turning in of the edges of a structure.
database_cross_reference: ISBN:0781727286

avulsion
type: Class
subclass of: developmental or adult structural defect
definition: Tearing away or separation of two structures or parts.
has_obo_namespace: mouse_pathology.ontology
id: MPATH:625

Axiom
annotated source: avulsion
annotated property: definition
annotated target: Tearing away or separation of two structures or parts.
database_cross_reference: ISBN:0781727286

prolapse
type: Class
subclass of: developmental or adult structural defect
definition: To sink down, said of an organ or other part. A sinking of an organ or other part, especially its appearance at a natural or artificial orifice.
has_obo_namespace: mouse_pathology.ontology
id: MPATH:626

Axiom
annotated source: prolapse
annotated property: definition
annotated target: To sink down, said of an organ or other part. A sinking of an organ or other part, especially its appearance at a natural or artificial orifice.
database_cross_reference: ISBN:0781727286

pyogranulomatous inflammation
type: Class
subclass of: granulomatous inflammation
definition: An inflammatory process in which there is infiltration of polymorphonuclear cells into a more chronic area of inflammation characterized by mononuclear cells, macrophages, lymphocytes and possibly plasma cells.
has_obo_namespace: mouse_pathology.ontology
id: MPATH:627

Axiom
annotated source: pyogranulomatous inflammation
annotated property: definition
annotated target: An inflammatory process in which there is infiltration of polymorphonuclear cells into a more chronic area of inflammation characterized by mononuclear cells, macrophages, lymphocytes and possibly plasma cells.
database_cross_reference: Pathbase: Pathology Committee

pyogenic granuloma
type: Class
subclass of: hemangioma
definition: A small rounded mass of inflamed, highly vascular granulation tissue on the skin, frequently having an ulcerated surface. More likely a true neoplasm rather than a reactive lesion.
has_obo_namespace: mouse_pathology.ontology
has_related_synonym: lobular capillary hemangioma
id: MPATH:628

Axiom
annotated source: pyogenic granuloma
annotated property: definition
annotated target: A small rounded mass of inflamed, highly vascular granulation tissue on the skin, frequently having an ulcerated surface. More likely a true neoplasm rather than a reactive lesion.
database_cross_reference: Mills; S.E.; Cooper; P.H. & Fechner; R.E. (1980). Lobular capillary hemangioma: the underlying lesion of pyogenic granuloma. A study of 73 cases from the oral and nasal mucous membranes. Am J Surg Pathol; 4; 470-9.

Axiom
annotated source: pyogenic granuloma
annotated property: has_related_synonym
annotated target: lobular capillary hemangioma
database_cross_reference: Pathbase: Curation

cavernous hemangioma
type: Class
subclass of: hemangioma
definition: Deep cutaneous hemangioma with large dilated vascular spaces that manifests spontaneous involution.
has_obo_namespace: mouse_pathology.ontology
id: MPATH:629

Axiom
annotated source: cavernous hemangioma
annotated property: definition
annotated target: Deep cutaneous hemangioma with large dilated vascular spaces that manifests spontaneous involution.
database_cross_reference: ISBN:0781727286

depletion
type: Class
subclass of: developmental process abnormalities
definition: The removal of accumulated fluids or solids.
has_obo_namespace: mouse_pathology.ontology
id: MPATH:63

Axiom
annotated source: depletion
annotated property: definition
annotated target: The removal of accumulated fluids or solids.
database_cross_reference: Pathbase: Pathology Committee

karyomegaly
type: Class
subclass of: nuclear defect
definition: Abnormally increased nuclear size.
has_obo_namespace: mouse_pathology.ontology
id: MPATH:630

Axiom
annotated source: karyomegaly
annotated property: definition
annotated target: Abnormally increased nuclear size.
database_cross_reference: Pathbase: Pathology Committee

hypertrophic tissue
type: Class
subclass of: growth and differentiation defect
definition: Tissue or cells undergoing hypertrophy, MPATH: 159.
has_obo_namespace: mouse_pathology.ontology
id: MPATH:631

Axiom
annotated source: hypertrophic tissue
annotated property: definition
annotated target: Tissue or cells undergoing hypertrophy, MPATH: 159.
database_cross_reference: Pathbase: Pathology Committee

hepatocytomegaly
type: Class
subclass of: hypertrophic tissue
definition: Increase in size of hepatocytes characterised by organelle hyperplasia and enlarged cellular volume.
database_cross_reference: PMID:7943185
has_exact_synonym: Hepatocellular hypertrophy.
has_obo_namespace: mouse_pathology.ontology
id: MPATH:632
comment: Hepatocytomegaly is an enlargement of the hepatocytes and is generally classified into three types: hepatocellular hypertrophy, megalocytosis, and hepatocellular vacuolation. Hepatocellular hypertrophy is an enlargement of cellular diameter without accompanying nuclear changes, leading to a net gain in the dry mass of the liver. Megalocytosis is characterized by enlargement of both the cell and the nucleus, and hepatocellular vacuolation is characterized by vacuolation, or formation of pockets of fluid within the hepatocytes.

Axiom
annotated source: hepatocytomegaly
annotated property: definition
annotated target: Increase in size of hepatocytes characterised by organelle hyperplasia and enlarged cellular volume.
database_cross_reference: Journal: Ward; J.M.; Anver; M.R.; Haines; D.C. & Benveniste; R.E. (1994). Chronic active hepatitis in mice caused by Helicobacter hepaticus. Am J Pathol; 145; 959-68.

cholelithiasis
type: Class
subclass of: concretion
definition: Presence of concretions in the gallbladder or bile ducts.
has_obo_namespace: mouse_pathology.ontology
id: MPATH:633

Axiom
annotated source: cholelithiasis
annotated property: definition
annotated target: Presence of concretions in the gallbladder or bile ducts.
database_cross_reference: ISBN:0781727286

furunculosis
type: Class
subclass of: inflammation
definition: Focal suppurative inflammation of the skin and subcutaneous tissues, enclosing a central slough or `core`.
has_obo_namespace: mouse_pathology.ontology
has_related_synonym: Boil
id: MPATH:634

Axiom
annotated source: furunculosis
annotated property: definition
annotated target: Focal suppurative inflammation of the skin and subcutaneous tissues, enclosing a central slough or `core`.
database_cross_reference: ISBN:9780702027888

Axiom
annotated source: furunculosis
annotated property: has_related_synonym
annotated target: Boil
database_cross_reference: Pathbase: Curation

hydronephrosis
type: Class
subclass of: pyelectasia
definition: Swelling of the kidneys when urine flow is obstructed in any of part of the urinary tract. Severe form of pyelectasia.
has_obo_namespace: mouse_pathology.ontology
id: MPATH:635

Axiom
annotated source: hydronephrosis
annotated property: definition
annotated target: Swelling of the kidneys when urine flow is obstructed in any of part of the urinary tract. Severe form of pyelectasia.
database_cross_reference: ISBN:9780702027888

steatitis
type: Class
subclass of: inflammation
definition: Inflammation of fatty tissue.
has_obo_namespace: mouse_pathology.ontology
id: MPATH:636

Axiom
annotated source: steatitis
annotated property: definition
annotated target: Inflammation of fatty tissue.
database_cross_reference: Pathbase: Pathology Committee

bursal cyst
type: Class
subclass of: cyst
definition: A retention cyst, resulting from an obstruction to the duct of a gland, within a bursa.
has_obo_namespace: mouse_pathology.ontology
id: MPATH:637

Axiom
annotated source: bursal cyst
annotated property: definition
annotated target: A retention cyst, resulting from an obstruction to the duct of a gland, within a bursa.
database_cross_reference: Pathbase: Pathology Committee

cellulitis
type: Class
subclass of: inflammation
definition: An acute, diffuse, spreading, edematous, suppurative inflammation of the deep subcutaneous tissues and sometimes muscle, which may be associated with abscess formation.
has_obo_namespace: mouse_pathology.ontology
id: MPATH:638
comment: It is usually caused by infection of an operative or traumatic wound, burn or other cutaneous lesion by various bacteria, but group A streptococci and Staphylococcus aureus are the most common aetiological agents.

Axiom
annotated source: cellulitis
annotated property: definition
annotated target: An acute, diffuse, spreading, edematous, suppurative inflammation of the deep subcutaneous tissues and sometimes muscle, which may be associated with abscess formation.
database_cross_reference: URL:http://cancerweb.ncl.ac.uk/cgi-bin/omd?action=Search+OMD&query=cellulitis

hydrocephalus
type: Class
subclass of: intracellular and extracellular accumulation
definition: Accumulation of water in the ventricles of the brain.
has_obo_namespace: mouse_pathology.ontology
id: MPATH:639

Axiom
annotated source: hydrocephalus
annotated property: definition
annotated target: Accumulation of water in the ventricles of the brain.
database_cross_reference: Pathbase: Pathology Committee

developmental dysplasia
type: Class
subclass of: developmental process abnormalities
definition: Abnormal development (of organs or tissues) or an abnormal structure resulting from such growth.
has_obo_namespace: mouse_pathology.ontology
id: MPATH:64
comment: The word dysplasia as commonly used refers to a precursor state to neoplasia. This is not the context used for this MPATH term.

Axiom
annotated source: developmental dysplasia
annotated property: definition
annotated target: Abnormal development (of organs or tissues) or an abnormal structure resulting from such growth.
database_cross_reference: Pathbase: Pathology Committee

osteoid deposition
type: Class
subclass of: extracellular matrix deposition
definition: Deposition of organic bone matrix.
has_obo_namespace: mouse_pathology.ontology
id: MPATH:640

Axiom
annotated source: osteoid deposition
annotated property: definition
annotated target: Deposition of organic bone matrix.
database_cross_reference: Pathbase: Pathology Committee

epidermal inclusion cyst
type: Class
subclass of: cyst
definition: Intradermal or subcutaneous cyst, the wall of which is stratified epithelium containing keratohyalin granules, surrounding a core of debris.
has_obo_namespace: mouse_pathology.ontology
id: MPATH:641

Axiom
annotated source: epidermal inclusion cyst
annotated property: definition
annotated target: Intradermal or subcutaneous cyst, the wall of which is stratified epithelium containing keratohyalin granules, surrounding a core of debris.
database_cross_reference: Pathbase: Curation

cholesterol deposition
type: Class
subclass of: intracellular and extracellular accumulation
definition: Intra or extracellular deposition of cholesterol.
has_obo_namespace: mouse_pathology.ontology
id: MPATH:642
comment: Often diagnosed morphologically by the presence of cholesterol clefts - bare regions of a section where accumulated cholesterol has been removed by histological processing.

Axiom
annotated source: cholesterol deposition
annotated property: definition
annotated target: Intra or extracellular deposition of cholesterol.
database_cross_reference: Pathbase: Curation

serous exudate
type: Class
subclass of: fluid accumulation
definition: Non-cellular fluid that filters from the circulatory system and accumulates in lesions or areas of inflammation.
has_obo_namespace: mouse_pathology.ontology
id: MPATH:643

Axiom
annotated source: serous exudate
annotated property: definition
annotated target: Non-cellular fluid that filters from the circulatory system and accumulates in lesions or areas of inflammation.
database_cross_reference: Pathbase: Pathology Committee

crystalloid formation
type: Class
subclass of: intracellular and extracellular accumulation
definition: Accumulation of chitinase-like protein.
has_obo_namespace: mouse_pathology.ontology
id: MPATH:644

Axiom
annotated source: crystalloid formation
annotated property: definition
annotated target: Accumulation of chitinase-like protein.
database_cross_reference: Pathbase: Curation

epicarditis
type: Class
subclass of: inflammation
created by: George Gkoutos
creation date: 2011-03-22T03:09:08Z
has_obo_namespace: mouse_pathology.ontology
id: MPATH:645

chondroarthritis
type: Class
subclass of: inflammation
created by: George Gkoutos
creation date: 2011-03-22T03:12:07Z
has_obo_namespace: mouse_pathology.ontology
id: MPATH:646

interstitial nephritis
type: Class
subclass of: inflammation
subclass of: nephritis
created by: George Gkoutos
creation date: 2011-03-22T03:14:35Z
has_obo_namespace: mouse_pathology.ontology
id: MPATH:647

interstitial pancreatitis
type: Class
subclass of: inflammation
created by: George Gkoutos
creation date: 2011-03-22T03:16:02Z
has_obo_namespace: mouse_pathology.ontology
id: MPATH:648

otitis media
type: Class
subclass of: inflammation
created by: George Gkoutos
creation date: 2011-03-22T03:16:36Z
has_obo_namespace: mouse_pathology.ontology
id: MPATH:649

developmental hypoplasia
type: Class
definition: Underdevelopment of an organ due to a decrease in the number of cells through failure to proliferate leading to lack of development.
has_obo_namespace: mouse_pathology.ontology
id: MPATH:65
deprecated: true

Axiom
annotated source: developmental hypoplasia
annotated property: definition
annotated target: Underdevelopment of an organ due to a decrease in the number of cells through failure to proliferate leading to lack of development.
database_cross_reference: Pathbase: Pathology Committee

proliferative dermatitis
type: Class
subclass of: inflammation
created by: George Gkoutos
creation date: 2011-03-22T03:17:25Z
has_obo_namespace: mouse_pathology.ontology
id: MPATH:650

ventral glossitis
type: Class
subclass of: glossitis
created by: George Gkoutos
creation date: 2011-03-22T03:18:00Z
has_obo_namespace: mouse_pathology.ontology
id: MPATH:651

histiocytosis
type: Class
subclass of: immune mediated disease
subclass of: hyperplastic tissue
definition: Benign proliferation of histiocytes.
created by: George Gkoutos
creation date: 2011-03-22T03:19:47Z
has_alternative_id: MPATH:146
has_obo_namespace: mouse_pathology.ontology
id: MPATH:652

Axiom
annotated source: histiocytosis
annotated property: definition
annotated target: Benign proliferation of histiocytes.
database_cross_reference: MPATH:curation

langerhans cell histiocytosis
type: Class
subclass of: histiocytosis
created by: George Gkoutos
creation date: 2011-03-22T03:20:12Z
has_exact_synonym: histiocytosis X
has_obo_namespace: mouse_pathology.ontology
id: MPATH:653

non-Langerhans cell histiocytosis
type: Class
subclass of: histiocytosis
created by: George Gkoutos
creation date: 2011-03-22T03:20:52Z
has_exact_synonym: hemophagocytic syndrome
has_obo_namespace: mouse_pathology.ontology
id: MPATH:654

lingual adenitis
type: Class
subclass of: inflammation
created by: George Gkoutos
creation date: 2011-03-22T03:36:05Z
has_obo_namespace: mouse_pathology.ontology
id: MPATH:655

hemolysis
type: Class
subclass of: tissue specific degenerative process
definition: Rupture or disruption of erythrocytes with release of contents.
created by: Paul
creation date: 2011-04-01T12:08:29Z
has_obo_namespace: mouse_pathology.ontology
id: MPATH:656
comment: May be immune-mediated, induced by infectious organisms, or intrinsic disturbance of cell physiology or membrane/cytoskeletal integrity.

Axiom
annotated source: hemolysis
annotated property: definition
annotated target: Rupture or disruption of erythrocytes with release of contents.
database_cross_reference: MPATH:Curation

rhinitis
type: Class
subclass of: inflammation
created by: George Gkoutos
creation date: 2011-03-22T03:45:17Z
has_obo_namespace: mouse_pathology.ontology
id: MPATH:657

foreign body rhinitis
type: Class
subclass of: rhinitis
created by: George Gkoutos
creation date: 2011-03-22T03:45:36Z
has_obo_namespace: mouse_pathology.ontology
id: MPATH:658

foreign body dermatitis
type: Class
subclass of: dermatitis
created by: George Gkoutos
creation date: 2011-03-22T03:46:02Z
has_obo_namespace: mouse_pathology.ontology
id: MPATH:659

dilatation
type: Class
subclass of: developmental or adult structural defect
definition: Increase in the diameter of an orifice or tubular structure beyond its normal dimensions.
has_obo_namespace: mouse_pathology.ontology
id: MPATH:66

Axiom
annotated source: dilatation
annotated property: definition
annotated target: Increase in the diameter of an orifice or tubular structure beyond its normal dimensions.
database_cross_reference: Pathbase: Pathology Committee

gastritis
type: Class
subclass of: inflammation
created by: George Gkoutos
creation date: 2011-03-22T03:46:42Z
has_obo_namespace: mouse_pathology.ontology
id: MPATH:660

foreign body gastritis
type: Class
subclass of: gastritis
created by: George Gkoutos
creation date: 2011-03-22T03:47:05Z
has_obo_namespace: mouse_pathology.ontology
id: MPATH:661

foreign body glossitis
type: Class
subclass of: glossitis
created by: George Gkoutos
creation date: 2011-03-22T03:47:40Z
has_obo_namespace: mouse_pathology.ontology
id: MPATH:662

peritonitis
type: Class
subclass of: inflammation
created by: George Gkoutos
creation date: 2011-03-22T03:48:33Z
has_obo_namespace: mouse_pathology.ontology
id: MPATH:663

granulomatous peritonitis
type: Class
subclass of: granulomatous inflammation
subclass of: peritonitis
created by: George Gkoutos
creation date: 2011-03-22T03:48:51Z
has_obo_namespace: mouse_pathology.ontology
id: MPATH:664

foreign body granulomatous peritonitis
type: Class
subclass of: granulomatous inflammation
subclass of: peritonitis
created by: George Gkoutos
creation date: 2011-03-22T03:49:26Z
has_obo_namespace: mouse_pathology.ontology
id: MPATH:665

periodontitis
type: Class
subclass of: inflammation
created by: George Gkoutos
creation date: 2011-03-22T03:50:05Z
has_obo_namespace: mouse_pathology.ontology
id: MPATH:666

foreign body periodontitis
type: Class
subclass of: periodontitis
created by: George Gkoutos
creation date: 2011-03-22T03:50:24Z
has_obo_namespace: mouse_pathology.ontology
id: MPATH:667

tracheitis
type: Class
subclass of: inflammation
created by: George Gkoutos
creation date: 2011-03-22T03:51:20Z
has_obo_namespace: mouse_pathology.ontology
id: MPATH:668

foreign body tracheitis
type: Class
subclass of: tracheitis
created by: George Gkoutos
creation date: 2011-03-22T03:52:00Z
has_obo_namespace: mouse_pathology.ontology
id: MPATH:669

displacement and deformity
type: Class
subclass of: developmental or adult structural defect
definition: Abnormal location, orientation, number, loss or non-specified deformity of a structure or tissue.
has_obo_namespace: mouse_pathology.ontology
id: MPATH:67

Axiom
annotated source: displacement and deformity
annotated property: definition
annotated target: Abnormal location, orientation, number, loss or non-specified deformity of a structure or tissue.
database_cross_reference: Pathbase: Pathology Committee

granulomatous epicarditis
type: Class
subclass of: granulomatous inflammation
subclass of: epicarditis
definition: A mixed inflammatory cell infiltrate, primarily macrophages and some syncitial cells, around the heart attached to the epicardium.
created by: George Gkoutos
creation date: 2011-03-22T03:52:48Z
has_obo_namespace: mouse_pathology.ontology
id: MPATH:670

Axiom
annotated source: granulomatous epicarditis
annotated property: definition
annotated target: A mixed inflammatory cell infiltrate, primarily macrophages and some syncitial cells, around the heart attached to the epicardium.
database_cross_reference: MPATH:Sundberg

mastitis
type: Class
subclass of: inflammation
created by: George Gkoutos
creation date: 2011-02-19T04:01:58Z
has_obo_namespace: mouse_pathology.ontology
id: MPATH:671

mastocytosis
type: Class
subclass of: inflammation
created by: George Gkoutos
creation date: 2011-02-19T04:05:08Z
has_exact_synonym: Urticaria pigmentosa
has_obo_namespace: mouse_pathology.ontology
id: MPATH:672

metritis
type: Class
subclass of: inflammation
created by: George Gkoutos
creation date: 2011-02-19T04:06:30Z
has_obo_namespace: mouse_pathology.ontology
id: MPATH:673

osteomyelitis
type: Class
subclass of: inflammation
created by: George Gkoutos
creation date: 2011-02-19T04:08:00Z
has_obo_namespace: mouse_pathology.ontology
id: MPATH:674

psoriasiform dermatitis
type: Class
subclass of: dermatitis
created by: George Gkoutos
creation date: 2011-02-19T04:09:12Z
has_obo_namespace: mouse_pathology.ontology
id: MPATH:675

nephritis
type: Class
subclass of: inflammation
created by: George Gkoutos
creation date: 2011-02-19T04:10:14Z
has_obo_namespace: mouse_pathology.ontology
id: MPATH:676

pyelonephritis
type: Class
subclass of: nephritis
created by: George Gkoutos
creation date: 2011-02-19T04:10:51Z
has_obo_namespace: mouse_pathology.ontology
id: MPATH:677

septic nephritis
type: Class
subclass of: nephritis
created by: George Gkoutos
creation date: 2011-02-19T04:12:09Z
has_obo_namespace: mouse_pathology.ontology
id: MPATH:678

urocystitis
type: Class
subclass of: inflammation
created by: George Gkoutos
creation date: 2011-02-19T04:12:43Z
has_obo_namespace: mouse_pathology.ontology
id: MPATH:679

diverticulum
type: Class
subclass of: developmental or adult structural defect
definition: A blind ended outpouching through the wall of a tubular organ or bounded cavity.
has_obo_namespace: mouse_pathology.ontology
id: MPATH:68

Axiom
annotated source: diverticulum
annotated property: definition
annotated target: A blind ended outpouching through the wall of a tubular organ or bounded cavity.
database_cross_reference: Pathbase: Curation

septic urocystitis
type: Class
subclass of: urocystitis
created by: George Gkoutos
creation date: 2011-02-19T04:13:07Z
has_obo_namespace: mouse_pathology.ontology
id: MPATH:680

septicemia
type: Class
subclass of: inflammation
created by: George Gkoutos
creation date: 2011-02-19T04:13:38Z
has_obo_namespace: mouse_pathology.ontology
id: MPATH:681

arteritis
type: Class
subclass of: vasculitis
created by: George Gkoutos
creation date: 2011-02-19T04:15:16Z
has_obo_namespace: mouse_pathology.ontology
id: MPATH:682

degenerative arthritis
type: Class
subclass of: arthritis
subclass of: tissue specific degenerative process
subclass of: arthropathy
created by: George Gkoutos
creation date: 2011-02-19T04:16:05Z
has_obo_namespace: mouse_pathology.ontology
id: MPATH:683

arthropathy
type: Class
subclass of: tissue specific degenerative process
subclass of: lingual adenitis
created by: George Gkoutos
creation date: 2011-02-19T04:17:26Z
has_obo_namespace: mouse_pathology.ontology
id: MPATH:684

accessory organ
type: Class
subclass of: supernumerary structure
created by: George Gkoutos
creation date: 2011-02-19T04:26:34Z
has_obo_namespace: mouse_pathology.ontology
id: MPATH:685

amputation
type: Class
subclass of: displacement and deformity
created by: George Gkoutos
creation date: 2011-02-19T04:30:20Z
has_obo_namespace: mouse_pathology.ontology
id: MPATH:686

autoamputation
type: Class
subclass of: amputation
created by: George Gkoutos
creation date: 2011-02-19T04:30:41Z
has_obo_namespace: mouse_pathology.ontology
id: MPATH:687

aortitis
type: Class
subclass of: vasculitis
created by: George Gkoutos
creation date: 2011-02-19T04:34:31Z
has_obo_namespace: mouse_pathology.ontology
id: MPATH:688

lymphangitis
type: Class
subclass of: vasculitis
created by: George Gkoutos
creation date: 2011-02-19T04:35:13Z
has_obo_namespace: mouse_pathology.ontology
id: MPATH:689

ectopia
type: Class
definition: ectopia
has_obo_namespace: mouse_pathology.ontology
id: MPATH:69
comment: obsolete - Subsumed into heterotopia MPATH:76
deprecated: true

Axiom
annotated source: ectopia
annotated property: definition
annotated target: ectopia
database_cross_reference: Pathbase: Curation

phlebitis
type: Class
subclass of: vasculitis
created by: George Gkoutos
creation date: 2011-02-19T04:36:16Z
has_obo_namespace: mouse_pathology.ontology
id: MPATH:690

pustule
type: Class
subclass of: abscess
created by: George Gkoutos
creation date: 2011-02-19T04:45:08Z
has_exact_synonym: cutaneous abscess
has_obo_namespace: mouse_pathology.ontology
id: MPATH:691

ulcerative blepharitis
type: Class
subclass of: blepharitis
created by: George Gkoutos
creation date: 2011-02-19T04:56:39Z
has_obo_namespace: mouse_pathology.ontology
id: MPATH:692

pyometra
type: Class
subclass of: metritis
created by: George Gkoutos
creation date: 2011-02-19T05:02:23Z
has_obo_namespace: mouse_pathology.ontology
id: MPATH:693

acidophilic anterior pituitary gland adenoma
type: Class
subclass of: adenoma
created by: George Gkoutos
creation date: 2011-02-19T05:05:05Z
has_obo_namespace: mouse_pathology.ontology
id: MPATH:694

spindle cell sarcoma
type: Class
subclass of: sarcoma
created by: George Gkoutos
creation date: 2011-02-19T05:12:17Z
has_obo_namespace: mouse_pathology.ontology
id: MPATH:695

spindle cell hyperplasia
type: Class
subclass of: hyperplastic tissue
created by: George Gkoutos
creation date: 2011-02-19T05:13:13Z
has_obo_namespace: mouse_pathology.ontology
id: MPATH:696

alopecia areata
type: Class
subclass of: alopecia
created by: George Gkoutos
creation date: 2011-02-19T05:17:30Z
has_obo_namespace: mouse_pathology.ontology
id: MPATH:697

exostosis
type: Class
subclass of: growth and differentiation defect
created by: George Gkoutos
creation date: 2011-02-19T05:23:34Z
has_obo_namespace: mouse_pathology.ontology
has_related_synonym: osteophytes
id: MPATH:698

ankylosing exostosis
type: Class
subclass of: exostosis
created by: George Gkoutos
creation date: 2011-02-19T05:24:05Z
has_obo_namespace: mouse_pathology.ontology
id: MPATH:699

coagulation necrosis
type: Class
subclass of: necrosis
definition: A type of necrosis in which the affected cells or tissue are reduced to homogeneous eosinophilic mass without nuclear staining, as a result of the protein coagulation, eg. Infarct. Tissue architecture persists.
has_obo_namespace: mouse_pathology.ontology
id: MPATH:7

Axiom
annotated source: coagulation necrosis
annotated property: definition
annotated target: A type of necrosis in which the affected cells or tissue are reduced to homogeneous eosinophilic mass without nuclear staining, as a result of the protein coagulation, eg. Infarct. Tissue architecture persists.
database_cross_reference: ISBN:0781727286

fistula
type: Class
subclass of: developmental or adult structural defect
definition: An abnormal passage between two internal organs or leading from a cavity to the body surface.
has_obo_namespace: mouse_pathology.ontology
id: MPATH:70

Axiom
annotated source: fistula
annotated property: definition
annotated target: An abnormal passage between two internal organs or leading from a cavity to the body surface.
database_cross_reference: Pathbase: Curation

ascites
type: Class
subclass of: intracellular and extracellular accumulation
created by: George Gkoutos
creation date: 2011-02-19T05:24:55Z
has_obo_namespace: mouse_pathology.ontology
id: MPATH:700

developmental aspermia
type: Class
subclass of: developmental process abnormalities
subclass of: aspermia
created by: George Gkoutos
creation date: 2011-02-19T05:29:50Z
has_obo_namespace: mouse_pathology.ontology
id: MPATH:701

acquired aspermia
type: Class
subclass of: aspermia
created by: George Gkoutos
creation date: 2011-02-19T05:30:40Z
has_obo_namespace: mouse_pathology.ontology
id: MPATH:702

developmental hypoplasia
type: Class
subclass of: developmental process abnormalities
created by: George Gkoutos
creation date: 2011-02-19T05:31:21Z
has_obo_namespace: mouse_pathology.ontology
id: MPATH:703

thyroiditis
type: Class
subclass of: inflammation
created by: George Gkoutos
creation date: 2011-02-19T08:28:41Z
has_obo_namespace: mouse_pathology.ontology
id: MPATH:704

acinar atrophy
type: Class
subclass of: atrophy
created by: George Gkoutos
creation date: 2011-02-19T10:33:51Z
has_obo_namespace: mouse_pathology.ontology
id: MPATH:705

cryptorchidism
type: Class
subclass of: organ specific developmental defect
created by: George Gkoutos
creation date: 2011-02-19T10:37:34Z
has_obo_namespace: mouse_pathology.ontology
id: MPATH:706

angiolipoma
type: Class
subclass of: lipomatous tumor
created by: George Gkoutos
creation date: 2011-02-20T08:44:41Z
has_obo_namespace: mouse_pathology.ontology
id: MPATH:707

pyelectasia
type: Class
subclass of: intracellular and extracellular accumulation
definition: Distension of the renal pelvis by accumulated fluid or urine.
created by: Paul
creation date: 2011-06-06T03:01:54Z
has_obo_namespace: mouse_pathology.ontology
id: MPATH:708
comment: May be fetal or adult.

Axiom
annotated source: pyelectasia
annotated property: definition
annotated target: Distension of the renal pelvis by accumulated fluid or urine.
database_cross_reference: :

alveolar rhabdomyosarcoma
type: Class
subclass of: rhabdomyosarcoma
definition: Malignant tumor of striated muscle or pluripotential mesenchymal stem cells composed mainly of small round cells, with some partial skeletal muscle differentiation.
created by: Paul
creation date: 2011-06-06T03:24:13Z
has_obo_namespace: mouse_pathology.ontology
id: MPATH:709

Axiom
annotated source: alveolar rhabdomyosarcoma
annotated property: definition
annotated target: Malignant tumor of striated muscle or pluripotential mesenchymal stem cells composed mainly of small round cells, with some partial skeletal muscle differentiation.
database_cross_reference: ICD-O:8920/3

fusion process defect
type: Class
subclass of: developmental process abnormalities
definition: Failure of two or more structures ( not voids or lumens) to join together.
has_obo_namespace: mouse_pathology.ontology
id: MPATH:71

Axiom
annotated source: fusion process defect
annotated property: definition
annotated target: Failure of two or more structures ( not voids or lumens) to join together.
database_cross_reference: ISBN:0781727286

embryonal rhabdomyosarcoma
type: Class
subclass of: rhabdomyosarcoma
definition: Malignant mesenchymal tumor that morphologically and phenotypically resembles embryonal skeletal muscle.
created by: Paul
creation date: 2011-06-06T03:31:11Z
has_exact_synonym: Myosarcoma
has_obo_namespace: mouse_pathology.ontology
has_related_synonym: Rhabdopoietic Sarcoma
has_related_synonym: Sarcoma Botryoides [Soft Tissues]
has_related_synonym: Embryonal Sarcoma
has_related_synonym: Malignant Rhabdomyoma
id: MPATH:710
comment: Includes spindle cell, botryoid, anaplastic.

Axiom
annotated source: embryonal rhabdomyosarcoma
annotated property: definition
annotated target: Malignant mesenchymal tumor that morphologically and phenotypically resembles embryonal skeletal muscle.
database_cross_reference: ICD-O:8910/3
database_cross_reference: ICDO-:8912/3

situs ambiguus
type: Class
subclass of: left/right axis defect
created by: George Gkoutos
creation date: 2011-02-20T12:06:02Z
has_obo_namespace: mouse_pathology.ontology
id: MPATH:711

heterotaxy
type: Class
subclass of: left/right axis defect
created by: George Gkoutos
creation date: 2011-02-20T12:06:38Z
has_obo_namespace: mouse_pathology.ontology
id: MPATH:712

situs ambiguus totalis
type: Class
subclass of: situs inversus
created by: George Gkoutos
creation date: 2011-02-20T12:07:15Z
database_cross_reference: XX:<new dbxref>
has_obo_namespace: mouse_pathology.ontology
has_related_synonym: situs inversus with dextrocardia
id: MPATH:713

situs inversus with levocardia
type: Class
subclass of: situs inversus
created by: George Gkoutos
creation date: 2011-02-20T12:08:14Z
has_obo_namespace: mouse_pathology.ontology
id: MPATH:714

sinusitis
type: Class
subclass of: inflammation
created by: George Gkoutos
creation date: 2011-02-20T12:10:00Z
has_obo_namespace: mouse_pathology.ontology
id: MPATH:715

ciliary motility defect
type: Class
subclass of: subcellular defect
created by: George Gkoutos
creation date: 2011-02-20T12:14:20Z
has_obo_namespace: mouse_pathology.ontology
has_related_synonym: primary ciliary dyskinesis
id: MPATH:716

sequestrum
type: Class
subclass of: cell and tissue damage
created by: George Gkoutos
creation date: 2011-02-20T02:28:51Z
has_obo_namespace: mouse_pathology.ontology
id: MPATH:717
comment: Most often used in the context of bone.

pre-sacral teratoma
type: Class
subclass of: teratoma
definition: Generally benign germ cell derived tumors of male or female containing derivatives from all three germ layers with differentiation in the malignant form being poor. Pre-sacral tumors located in the retrorectal space between the rectum and the sacrococcygeal part of the spine.
created by: Paul
creation date: 2011-06-06T03:39:01Z
has_obo_namespace: mouse_pathology.ontology
id: MPATH:718

Axiom
annotated source: pre-sacral teratoma
annotated property: definition
annotated target: Generally benign germ cell derived tumors of male or female containing derivatives from all three germ layers with differentiation in the malignant form being poor. Pre-sacral tumors located in the retrorectal space between the rectum and the sacrococcygeal part of the spine.
database_cross_reference: :

bronchiectasia
type: Class
subclass of: ectasia
created by: George Gkoutos
creation date: 2011-02-20T12:04:36Z
has_obo_namespace: mouse_pathology.ontology
id: MPATH:719

growth acceleration
type: Class
subclass of: developmental process abnormalities
definition: Increase in the rate of growth of an organism, organ or tissue as a consequence of increased proliferation, reduced cell death, or a combination. Not due to an increase in cell size; see Hypertrophy MPATH: 159.
has_obo_namespace: mouse_pathology.ontology
id: MPATH:72

Axiom
annotated source: growth acceleration
annotated property: definition
annotated target: Increase in the rate of growth of an organism, organ or tissue as a consequence of increased proliferation, reduced cell death, or a combination. Not due to an increase in cell size; see Hypertrophy MPATH: 159.
database_cross_reference: Pathbase: Pathology Committee

situs inversus
type: Class
subclass of: left/right axis defect
created by: George Gkoutos
creation date: 2011-02-20T12:05:38Z
has_obo_namespace: mouse_pathology.ontology
id: MPATH:720

sacrococcygeal teratoma
type: Class
subclass of: teratoma
definition: Generally benign germ cell derived tumors of male or female containing derivatives from all three germ layers with differentiation in the malignant form being poor. Sacrococcygeal tumors are located at the base of the coccyx.
created by: Paul
creation date: 2011-06-06T03:51:12Z
has_obo_namespace: mouse_pathology.ontology
id: MPATH:721

Axiom
annotated source: sacrococcygeal teratoma
annotated property: definition
annotated target: Generally benign germ cell derived tumors of male or female containing derivatives from all three germ layers with differentiation in the malignant form being poor. Sacrococcygeal tumors are located at the base of the coccyx.
database_cross_reference: :

rhabdomyoma
type: Class
subclass of: myomatous tumor
definition: Benign stromal tumors of the soft tissue with skeletal muscle differentiation.
created by: Paul
creation date: 2011-06-06T03:59:49Z
has_obo_namespace: mouse_pathology.ontology
id: MPATH:722
comment: Adult and fetal types.

Axiom
annotated source: rhabdomyoma
annotated property: definition
annotated target: Benign stromal tumors of the soft tissue with skeletal muscle differentiation.
database_cross_reference: ICD-O:M-8900/0
database_cross_reference: PMID:3525381

fibromatosis
type: Class
subclass of: fibroma
definition: Systemic manifestation of MPATH: 407.
created by: Paul
creation date: 2011-06-06T04:11:04Z
has_exact_synonym: Desmoid Tumor
has_obo_namespace: mouse_pathology.ontology
has_related_synonym: Musculoaponeurotic Fibromatosis
has_related_synonym: Aggressive Fibromatosis
has_related_synonym: Plantar Fibromatosis (Ledderhose Disease)
id: MPATH:723

Axiom
annotated source: fibromatosis
annotated property: definition
annotated target: Systemic manifestation of MPATH: 407.
database_cross_reference: ICDO:M-8822/1

xanthoma
type: Class
subclass of: lipid deposition
definition: Dermal, subcutaneous, or tendinous lesions characterized by accumulations of lipid-laden macrophages often rich in cholesterol.
created by: Paul
creation date: 2011-06-08T03:43:07Z
has_obo_namespace: mouse_pathology.ontology
id: MPATH:724

Axiom
annotated source: xanthoma
annotated property: definition
annotated target: Dermal, subcutaneous, or tendinous lesions characterized by accumulations of lipid-laden macrophages often rich in cholesterol.
database_cross_reference: MPATH:Pathology Committee

chronic interstitial nephritis
type: Class
subclass of: interstitial nephritis
created by: Paul
creation date: 2011-10-26T02:02:02Z
has_obo_namespace: mouse_pathology.ontology
id: MPATH:725

hemosiderosis
type: Class
subclass of: iron deposition
created by: Paul
creation date: 2011-10-26T02:05:04Z
has_obo_namespace: mouse_pathology.ontology
id: MPATH:726

hepatic hemosiderosis
type: Class
subclass of: hemosiderosis
created by: Paul
creation date: 2011-10-26T02:05:29Z
has_obo_namespace: mouse_pathology.ontology
id: MPATH:727

pulmonary hemosiderosis
type: Class
subclass of: hemosiderosis
created by: Paul
creation date: 2011-10-26T02:06:12Z
has_obo_namespace: mouse_pathology.ontology
id: MPATH:728

splenic melanosis
type: Class
subclass of: melanin deposition
created by: Paul
creation date: 2011-10-26T02:06:46Z
has_obo_namespace: mouse_pathology.ontology
id: MPATH:729

growth arrest
type: Class
subclass of: developmental process abnormalities
definition: The cessation of fetal or embryonic growth beyond a particular stage.
has_obo_namespace: mouse_pathology.ontology
id: MPATH:73

Axiom
annotated source: growth arrest
annotated property: definition
annotated target: The cessation of fetal or embryonic growth beyond a particular stage.
database_cross_reference: Pathbase: Pathology Committee

renal tubular concretion
type: Class
subclass of: concretion
created by: Paul
creation date: 2011-10-26T02:13:35Z
has_obo_namespace: mouse_pathology.ontology
id: MPATH:730

Leydig cell hyperplasia
type: Class
subclass of: hyperplastic tissue
created by: Paul
creation date: 2011-10-26T02:17:02Z
has_obo_namespace: mouse_pathology.ontology
id: MPATH:731

tracheal gland ectasia
type: Class
subclass of: ectasia
created by: Paul
creation date: 2011-10-26T02:19:12Z
has_obo_namespace: mouse_pathology.ontology
id: MPATH:732

mucometra
type: Class
subclass of: mucous secretions
definition: A uterus distended with a fluid containing large quantities of mucin.
created by: Paul
creation date: 2011-10-26T02:22:56Z
has_obo_namespace: mouse_pathology.ontology
id: MPATH:733

Axiom
annotated source: mucometra
annotated property: definition
annotated target: A uterus distended with a fluid containing large quantities of mucin.
database_cross_reference: MPATH:Sundberg

acute blepharitis
type: Class
subclass of: blepharitis
created by: Paul
creation date: 2011-10-26T02:23:54Z
has_obo_namespace: mouse_pathology.ontology
id: MPATH:734

molar hypercementosis
type: Class
subclass of: intracellular and extracellular accumulation
definition: Thickening of the cementum layer of the molars.
created by: Paul
creation date: 2011-10-26T02:25:55Z
has_obo_namespace: mouse_pathology.ontology
id: MPATH:735
comment: This is usually a normal adaptive response, serving to improve the functional properties of teeth during aging.

Axiom
annotated source: molar hypercementosis
annotated property: definition
annotated target: Thickening of the cementum layer of the molars.
database_cross_reference: MPATH:Sundberg

ovarian follicular cyst
type: Class
subclass of: cyst
created by: Paul
creation date: 2011-10-26T02:29:29Z
has_obo_namespace: mouse_pathology.ontology
id: MPATH:736
comment: A variety of cysts develop in the ovary. They are subdivided based on where they develop anatomically. Ovarian follicles in this case become large and fluid filled.

retinal degeneration
type: Class
subclass of: tissue specific degenerative process
created by: Paul
creation date: 2011-10-26T02:33:06Z
has_obo_namespace: mouse_pathology.ontology
id: MPATH:737
comment: Usually rd6-outer retinal photoreceptor degeneration

uterine cystic endometrial hyperplasia
type: Class
subclass of: hyperplasia
created by: Paul
creation date: 2011-10-26T02:34:35Z
has_obo_namespace: mouse_pathology.ontology
id: MPATH:738
comment: The uterus of older female mice often becomes distended with numerous fluid filled cysts that extend from the endometrium.

sub-retinal hemorrhage
type: Class
subclass of: hemorrhage and non-specified extravasation
definition: Extravascular blood between retina and choroid
created by: Paul
creation date: 2011-10-26T02:36:03Z
has_obo_namespace: mouse_pathology.ontology
id: MPATH:739

Axiom
annotated source: sub-retinal hemorrhage
annotated property: definition
annotated target: Extravascular blood between retina and choroid
database_cross_reference: MPATH:Sundberg

hamartoma
type: Class
subclass of: developmental or adult structural defect
definition: A focal malformation resembling a neoplasm which results from faulty development of an organ; composed of an abnormal mixture of tissue elements, or an abnormal proportion of a single element. Growth and location are usually normal for that tissue cf. Heterotopia/Choristoma MPATH:76/MPATH:477.
has_obo_namespace: mouse_pathology.ontology
id: MPATH:74

Axiom
annotated source: hamartoma
annotated property: definition
annotated target: A focal malformation resembling a neoplasm which results from faulty development of an organ; composed of an abnormal mixture of tissue elements, or an abnormal proportion of a single element. Growth and location are usually normal for that tissue cf. Heterotopia/Choristoma MPATH:76/MPATH:477.
database_cross_reference: ISBN:0781727286

drusen
type: Class
subclass of: protein deposition
definition: Tiny yellow or white deposits of lamellar or amorphous extracellular material that build up between retina and retinal pigment epithelium.
created by: Paul
creation date: 2011-10-26T02:38:14Z
has_obo_namespace: mouse_pathology.ontology
id: MPATH:740

Axiom
annotated source: drusen
annotated property: definition
annotated target: Tiny yellow or white deposits of lamellar or amorphous extracellular material that build up between retina and retinal pigment epithelium.
database_cross_reference: MPATH:Sundberg

splenomegaly
type: Class
subclass of: developmental or adult structural defect
definition: An increase in size of the spleen.
created by: Paul
creation date: 2011-10-26T02:56:13Z
has_obo_namespace: mouse_pathology.ontology
id: MPATH:741

Axiom
annotated source: splenomegaly
annotated property: definition
annotated target: An increase in size of the spleen.
database_cross_reference: MPATH:Sundberg

intervertebral disk prolapse
type: Class
subclass of: prolapse
definition: Rupture of the intervertebral disc, usually dorsally to compress the spinal cord, secondary to trauma.
created by: Paul
creation date: 2011-10-26T02:59:08Z
has_obo_namespace: mouse_pathology.ontology
id: MPATH:742
comment: These become more common with age.

Axiom
annotated source: intervertebral disk prolapse
annotated property: definition
annotated target: Rupture of the intervertebral disc, usually dorsally to compress the spinal cord, secondary to trauma.
database_cross_reference: MPATH:Sundberg

hepatic centrolobular fatty metamorphosis
type: Class
subclass of: steatosis
definition: Accumulation of clear large vacuoles in hepatocytes (most likely lipid pending frozen sections and oil red O or other lipid stains) around central veins.
created by: Paul
creation date: 2011-10-26T03:04:08Z
has_obo_namespace: mouse_pathology.ontology
id: MPATH:743

Axiom
annotated source: hepatic centrolobular fatty metamorphosis
annotated property: definition
annotated target: Accumulation of clear large vacuoles in hepatocytes (most likely lipid pending frozen sections and oil red O or other lipid stains) around central veins.
database_cross_reference: MPATH:Sundberg

pigmentary incontinence
type: Class
subclass of: intracellular and extracellular depletion
definition: Release of melanin pigment in the dermis.
created by: Paul
creation date: 2011-10-26T03:06:29Z
has_obo_namespace: mouse_pathology.ontology
id: MPATH:744
comment: Observed as melanin pigment within macrophages in the dermis. Inflammation in the epidermis stimulates melanocytes to increase the synthesis of melanin and subsequently to transfer the pigment to surrounding keratinocytes. If the basal layer is injured (e.g. lichen planus), melanin pigment is released and subsequently trapped by macrophages in the papillary dermis.

Axiom
annotated source: pigmentary incontinence
annotated property: definition
annotated target: Release of melanin pigment in the dermis.
database_cross_reference: MPATH:Sundberg

zenker's necrosis
type: Class
subclass of: necrosis
definition: Degenerative changes in skeletal muscle including hyalinization, swelling, fragmentation, vacuolation eventually resulting in death of muscle fibers.
created by: Paul
creation date: 2011-10-26T03:15:56Z
has_obo_namespace: mouse_pathology.ontology
id: MPATH:745

Axiom
annotated source: zenker's necrosis
annotated property: definition
annotated target: Degenerative changes in skeletal muscle including hyalinization, swelling, fragmentation, vacuolation eventually resulting in death of muscle fibers.
database_cross_reference: MPATH:Sundberg

cartilagenous erosion
type: Class
subclass of: tissue specific degenerative process
definition: Fragmentation and erosion of articular cartilage.
created by: Paul
creation date: 2011-10-26T03:18:38Z
has_obo_namespace: mouse_pathology.ontology
id: MPATH:746

Axiom
annotated source: cartilagenous erosion
annotated property: definition
annotated target: Fragmentation and erosion of articular cartilage.
database_cross_reference: MPATH::Sundberg

renal tubular amyloidosis
type: Class
subclass of: amyloid deposition
definition: Pink amorphous material (amyloid) deposited within the renal tubules.
created by: Paul
creation date: 2011-10-26T03:34:30Z
has_obo_namespace: mouse_pathology.ontology
id: MPATH:747

Axiom
annotated source: renal tubular amyloidosis
annotated property: definition
annotated target: Pink amorphous material (amyloid) deposited within the renal tubules.
database_cross_reference: MPATH:Sundberg

recanalised thrombus
type: Class
subclass of: thrombosis
definition: An old organized thrombus that has been recanalized to permit blood flow.
created by: Paul
creation date: 2011-10-26T03:36:06Z
has_obo_namespace: mouse_pathology.ontology
id: MPATH:748

Axiom
annotated source: recanalised thrombus
annotated property: definition
annotated target: An old organized thrombus that has been recanalized to permit blood flow.
database_cross_reference: MPATH:Sundberg

focal pulmonary fibrosis
type: Class
subclass of: fibrosis
definition: Various degrees of pulmonary interstitial fibrosis.
created by: Paul
creation date: 2011-10-26T03:37:48Z
has_obo_namespace: mouse_pathology.ontology
id: MPATH:749

Axiom
annotated source: focal pulmonary fibrosis
annotated property: definition
annotated target: Various degrees of pulmonary interstitial fibrosis.
database_cross_reference: MPATH:Sundberg

hernia
type: Class
subclass of: developmental or adult structural defect
definition: Protrusion of a loop or wall of an organ through an abnormal opening.
has_obo_namespace: mouse_pathology.ontology
id: MPATH:75

Axiom
annotated source: hernia
annotated property: definition
annotated target: Protrusion of a loop or wall of an organ through an abnormal opening.
database_cross_reference: Pathbase: Curation

pulmonary adenomatosis
type: Class
subclass of: adenoma
definition: Neoplastic proliferation of cuboidal cells lining alveoli most likely type II pneumocytes.
created by: Paul
creation date: 2011-10-26T03:40:09Z
has_obo_namespace: mouse_pathology.ontology
id: MPATH:750

Axiom
annotated source: pulmonary adenomatosis
annotated property: definition
annotated target: Neoplastic proliferation of cuboidal cells lining alveoli most likely type II pneumocytes.
database_cross_reference: MPATH:Sundberg

pigment dispersion
type: Class
subclass of: intracellular and extracellular depletion
definition: Free pigment in anterior chamber/elsewhere in eye.
created by: Paul
creation date: 2011-10-26T03:41:56Z
has_obo_namespace: mouse_pathology.ontology
id: MPATH:751

Axiom
annotated source: pigment dispersion
annotated property: definition
annotated target: Free pigment in anterior chamber/elsewhere in eye.
database_cross_reference: MPATH:Sundberg

barbered
type: Class
subclass of: developmental or adult structural defect
definition: loss of hair resulting from a behavioral abnormality in which the mouse, or more often other mice mice in the same box, remove hairs, initially vibrissae, from each other.
created by: Paul
creation date: 2011-10-26T03:44:05Z
has_obo_namespace: mouse_pathology.ontology
id: MPATH:752
comment: This is a form of trichotillomania.

Axiom
annotated source: barbered
annotated property: definition
annotated target: loss of hair resulting from a behavioral abnormality in which the mouse, or more often other mice mice in the same box, remove hairs, initially vibrissae, from each other.
database_cross_reference: MPATH:Sundberg

gastric forestomach papillomatous hyperplasia
type: Class
subclass of: epithelial hyperplasia
definition: The forestomach of the mouse is lined by stratified squamous epithelia. At the limiting ridge there is hyperplasia to various degrees in which this epithelium proliferates to form raised areas on thin fibrovascular stalks.
created by: Paul
creation date: 2011-10-26T03:47:01Z
has_obo_namespace: mouse_pathology.ontology
id: MPATH:753

Axiom
annotated source: gastric forestomach papillomatous hyperplasia
annotated property: definition
annotated target: The forestomach of the mouse is lined by stratified squamous epithelia. At the limiting ridge there is hyperplasia to various degrees in which this epithelium proliferates to form raised areas on thin fibrovascular stalks.
database_cross_reference: MPATH:Sundberg

splenic hemosiderosis
type: Class
subclass of: hemosiderosis
definition: Spleen contains foci of macrophages containing yellow brown pigment that is positive for iron using Prussian blue.
created by: Paul
creation date: 2011-11-02T03:30:56Z
has_obo_namespace: mouse_pathology.ontology
id: MPATH:754

Axiom
annotated source: splenic hemosiderosis
annotated property: definition
annotated target: Spleen contains foci of macrophages containing yellow brown pigment that is positive for iron using Prussian blue.
database_cross_reference: MPATH:Sundberg

pulmonary interstitial mineralisation
type: Class
subclass of: mineralisation
subclass of: interstitial mineralization
definition: Small foci of mineralization within the interstitium between alveoli.
created by: Paul
creation date: 2011-11-02T03:33:11Z
has_obo_namespace: mouse_pathology.ontology
id: MPATH:755

Axiom
annotated source: pulmonary interstitial mineralisation
annotated property: definition
annotated target: Small foci of mineralization within the interstitium between alveoli.
database_cross_reference: MPATH:Sundberg

polyarteritis nodosa
type: Class
subclass of: arteritis
definition: Chronic inflammation in and around small and medium sized arteries, often in more than one location.
created by: Paul
creation date: 2011-11-02T03:41:52Z
has_obo_namespace: mouse_pathology.ontology
has_related_synonym: Kussmaul disease
has_related_synonym: Kussmaul-Maier disease
id: MPATH:756

Axiom
annotated source: polyarteritis nodosa
annotated property: definition
annotated target: Chronic inflammation in and around small and medium sized arteries, often in more than one location.
database_cross_reference: MPATH:Sundberg

interstitial mineralization
type: Class
subclass of: mineralisation
definition: Foci of mineralization within the interstitium of a tissue.
created by: Paul
creation date: 2011-11-02T03:54:07Z
has_obo_namespace: mouse_pathology.ontology
id: MPATH:757

Axiom
annotated source: interstitial mineralization
annotated property: definition
annotated target: Foci of mineralization within the interstitium of a tissue.
database_cross_reference: MPATH:Sundberg

renal interstitial mineralisation
type: Class
subclass of: interstitial mineralization
definition: Small foci of mineralization within the interstitium between tubules.
created by: Paul
creation date: 2011-11-02T03:57:16Z
has_obo_namespace: mouse_pathology.ontology
id: MPATH:758

Axiom
annotated source: renal interstitial mineralisation
annotated property: definition
annotated target: Small foci of mineralization within the interstitium between tubules.
database_cross_reference: MPATH:Sundberg

pseudocyesis
type: Class
subclass of: ectasia
definition: Appearance of clinical and/or subclinical signs and symptoms associated with pregnancy when the animal is not pregnant
created by: Paul
creation date: 2011-11-02T04:02:14Z
database_cross_reference: XX:<new xref>
has_exact_synonym: false pregnancy
has_obo_namespace: mouse_pathology.ontology
id: MPATH:759
comment: Virgin females have mammary acini and ducts dilated to various degrees filled with proteinaceous materials suggestive of lactation or involution.

Axiom
annotated source: pseudocyesis
annotated property: definition
annotated target: Appearance of clinical and/or subclinical signs and symptoms associated with pregnancy when the animal is not pregnant
database_cross_reference: MPATH:Sundberg

heterotopia
type: Class
subclass of: displacement and deformity
definition: Congenital appearance of a body part or tissue or cell type in a region where it is not normally found ( topographical anomaly).
has_obo_namespace: mouse_pathology.ontology
has_related_synonym: Ectopia
id: MPATH:76

Axiom
annotated source: heterotopia
annotated property: definition
annotated target: Congenital appearance of a body part or tissue or cell type in a region where it is not normally found ( topographical anomaly).
database_cross_reference: Pathbase: Pathology Committee

Axiom
annotated source: heterotopia
annotated property: has_related_synonym
annotated target: Ectopia
database_cross_reference: Pathbase: Curation

ovarian bursal cyst
type: Class
subclass of: bursal cyst
definition: Marked dilatation of the ovarian bursa.
created by: Paul
creation date: 2011-11-02T04:07:28Z
has_obo_namespace: mouse_pathology.ontology
id: MPATH:760
comment: May compress the ovary

Axiom
annotated source: ovarian bursal cyst
annotated property: definition
annotated target: Marked dilatation of the ovarian bursa.
database_cross_reference: MPATH:Sundberg

muscle regeneration
type: Class
subclass of: healing and repair structure
definition: Linear palisaiding of nuclei within thin pale muscle fibers suggestive of repair.
created by: Paul
creation date: 2011-11-02T04:14:39Z
has_obo_namespace: mouse_pathology.ontology
id: MPATH:761

Axiom
annotated source: muscle regeneration
annotated property: definition
annotated target: Linear palisaiding of nuclei within thin pale muscle fibers suggestive of repair.
database_cross_reference: MPATH:Sundberg

thyroid follicle pleomorphism
type: Class
subclass of: intracellular and extracellular accumulation
definition: Thyroid gland follicles are filled with colloid but vary greatly in size.
created by: Paul
creation date: 2011-11-02T04:18:38Z
has_obo_namespace: mouse_pathology.ontology
id: MPATH:762
comment: Suggestive of goiter or other functional abnormality.

Axiom
annotated source: thyroid follicle pleomorphism
annotated property: definition
annotated target: Thyroid gland follicles are filled with colloid but vary greatly in size.
database_cross_reference: MPATH:Sundberg

sialocele
type: Class
subclass of: cyst
definition: Salivary gland duct occlusion resulting in massive enlargement forming a large cyst-like structure.
created by: Paul
creation date: 2011-11-02T04:23:20Z
has_obo_namespace: mouse_pathology.ontology
id: MPATH:763

Axiom
annotated source: sialocele
annotated property: definition
annotated target: Salivary gland duct occlusion resulting in massive enlargement forming a large cyst-like structure.
database_cross_reference: MPATH:Sundberg

fracture
type: Class
subclass of: developmental or adult structural defect
definition: A fracture is the (local) separation of a bone into two, or more, pieces under the action of stress.
created by: Paul
creation date: 2011-11-02T04:29:57Z
has_obo_namespace: mouse_pathology.ontology
id: MPATH:764

Axiom
annotated source: fracture
annotated property: definition
annotated target: A fracture is the (local) separation of a bone into two, or more, pieces under the action of stress.
database_cross_reference: MPATH:PNS

fracture and healing
type: Class
subclass of: fracture
definition: Break in bone associated with exostoses.
created by: Paul
creation date: 2011-11-02T04:34:27Z
has_obo_namespace: mouse_pathology.ontology
id: MPATH:765

Axiom
annotated source: fracture and healing
annotated property: definition
annotated target: Break in bone associated with exostoses.
database_cross_reference: MPATH:Sundberg

intestinal amyloidosis
type: Class
subclass of: amyloid deposition
definition: The lamina propria is distended with amorphous hyalinized material interpreted to be amyloid protein.
created by: Paul
creation date: 2011-11-02T06:59:37Z
has_obo_namespace: mouse_pathology.ontology
id: MPATH:766

Axiom
annotated source: intestinal amyloidosis
annotated property: definition
annotated target: The lamina propria is distended with amorphous hyalinized material interpreted to be amyloid protein.
database_cross_reference: MPATH:Sundberg

Meckel's diverticulum
type: Class
subclass of: diverticulum
definition: A Meckel's diverticulum is a pouch on the wall of the lower part of the intestine that is present at birth.
created by: Paul
creation date: 2011-11-02T07:05:54Z
has_obo_namespace: mouse_pathology.ontology
id: MPATH:767

Axiom
annotated source: Meckel's diverticulum
annotated property: definition
annotated target: A Meckel's diverticulum is a pouch on the wall of the lower part of the intestine that is present at birth.
database_cross_reference: PMH:0001281

septic necrosis
type: Class
subclass of: necrosis
definition: Necrosis associated with or caused by local bacterial infection.
created by: Paul
creation date: 2011-11-02T07:11:40Z
has_obo_namespace: mouse_pathology.ontology
id: MPATH:768

Axiom
annotated source: septic necrosis
annotated property: definition
annotated target: Necrosis associated with or caused by local bacterial infection.
database_cross_reference: MPATH:Sundberg

uterine septic necrosis
type: Class
subclass of: septic necrosis
definition: Necrosis of the uterine wall with large bacterial colonies on its surface.
created by: Paul
creation date: 2011-11-02T07:15:32Z
has_obo_namespace: mouse_pathology.ontology
id: MPATH:769

Axiom
annotated source: uterine septic necrosis
annotated property: definition
annotated target: Necrosis of the uterine wall with large bacterial colonies on its surface.
database_cross_reference: MPATH:Sundberg

homoeotic change
type: Class
subclass of: developmental process abnormalities
definition: Stricto sensu: replacement of one body part or tissue by an homologous structure or tissue, but commonly used incorrectly to describe non-homologous transformations better described as heterotopias or ectopias.
has_obo_namespace: mouse_pathology.ontology
id: MPATH:77

Axiom
annotated source: homoeotic change
annotated property: definition
annotated target: Stricto sensu: replacement of one body part or tissue by an homologous structure or tissue, but commonly used incorrectly to describe non-homologous transformations better described as heterotopias or ectopias.
database_cross_reference: Pathbase: Pathology Committee

abnormal organ size
type: Class
subclass of: organ specific developmental defect
definition: Abnormal organ dimensions or weight
created by: Paul
creation date: 2011-11-02T07:19:32Z
has_obo_namespace: mouse_pathology.ontology
id: MPATH:770

Axiom
annotated source: abnormal organ size
annotated property: definition
annotated target: Abnormal organ dimensions or weight
database_cross_reference: MPATH:<new dbxref>
database_cross_reference: MPATH:PNS

abnormal organ length
type: Class
subclass of: abnormal organ size
definition: Abnormality of extent of the normal long axis
created by: Paul
creation date: 2011-11-02T07:21:06Z
has_obo_namespace: mouse_pathology.ontology
id: MPATH:771

Axiom
annotated source: abnormal organ length
annotated property: definition
annotated target: Abnormality of extent of the normal long axis
database_cross_reference: MPATH:<new dbxref>
database_cross_reference: MPATH:PNS

abnormal organ mass
type: Class
subclass of: abnormal organ size
definition: Abnormal mass of organ
created by: Paul
creation date: 2011-11-02T07:22:00Z
has_obo_namespace: mouse_pathology.ontology
id: MPATH:772

Axiom
annotated source: abnormal organ mass
annotated property: definition
annotated target: Abnormal mass of organ
database_cross_reference: MPATH:<new dbxref>
database_cross_reference: MPATH:PNS

abnormal intestine length
type: Class
subclass of: abnormal organ length
definition: Abnormal length of the intestine.
created by: Paul
creation date: 2011-11-02T07:22:44Z
has_obo_namespace: mouse_pathology.ontology
id: MPATH:773

Axiom
annotated source: abnormal intestine length
annotated property: definition
annotated target: Abnormal length of the intestine.
database_cross_reference: MPATH:PNS

focal hepatic coagulative necrosis
type: Class
subclass of: coagulation necrosis
definition: Focal necrosis in the liver often but not always associated with thrombosis.
created by: Paul
creation date: 2011-11-02T07:24:44Z
has_obo_namespace: mouse_pathology.ontology
id: MPATH:774

Axiom
annotated source: focal hepatic coagulative necrosis
annotated property: definition
annotated target: Focal necrosis in the liver often but not always associated with thrombosis.
database_cross_reference: MPATH:Sundberg

compression
type: Class
subclass of: general degenerative process
definition: Exertion of abnormal force on a structure or structures usually resulting in deformation and damage.
created by: Paul
creation date: 2011-11-02T07:27:38Z
has_obo_namespace: mouse_pathology.ontology
id: MPATH:775

Axiom
annotated source: compression
annotated property: definition
annotated target: Exertion of abnormal force on a structure or structures usually resulting in deformation and damage.
database_cross_reference: MPATH:PNS
database_cross_reference: mpath:<new dbxref>

spermatocoele
type: Class
subclass of: cyst
definition: A spermatocoele is a cyst that contains spermatozoa. .
created by: Paul
creation date: 2011-11-02T07:30:33Z
has_obo_namespace: mouse_pathology.ontology
id: MPATH:776
comment: They occur in the head of the epididymis or less commonly, in the spermatic cord.

Axiom
annotated source: spermatocoele
annotated property: definition
annotated target: A spermatocoele is a cyst that contains spermatozoa. .
database_cross_reference: MPATH:PNS

urelithiasis
type: Class
subclass of: concretion
definition: Formation of urinary concretions in any part of the kidney.
created by: Paul
creation date: 2011-11-02T07:32:55Z
has_obo_namespace: mouse_pathology.ontology
id: MPATH:777

Axiom
annotated source: urelithiasis
annotated property: definition
annotated target: Formation of urinary concretions in any part of the kidney.
database_cross_reference: MPATH:PNS

corpora amylacea
type: Class
subclass of: concretion
definition: https://doi.org/10.1038/srep41807
created by: Paul
creation date: 2011-11-02T07:34:59Z
has_obo_namespace: mouse_pathology.ontology
id: MPATH:778

Axiom
annotated source: corpora amylacea
annotated property: definition
annotated target: https://doi.org/10.1038/srep41807
database_cross_reference: MPATH:PNS

uretolithiasis
type: Class
subclass of: urelithiasis
definition: Formation or urinary concretions in the ureter.
created by: Paul
creation date: 2011-11-02T07:36:04Z
has_obo_namespace: mouse_pathology.ontology
id: MPATH:779

Axiom
annotated source: uretolithiasis
annotated property: definition
annotated target: Formation or urinary concretions in the ureter.
database_cross_reference: MPATH:PNS

incomplete closure
type: Class
subclass of: developmental process abnormalities
definition: Incomplete closure of a void or lumen due to failure of growth or fusion of bounding walls.
has_obo_namespace: mouse_pathology.ontology
id: MPATH:78

Axiom
annotated source: incomplete closure
annotated property: definition
annotated target: Incomplete closure of a void or lumen due to failure of growth or fusion of bounding walls.
database_cross_reference: Pathbase: Pathology Committee

pseudoxanthoma elasticum
type: Class
subclass of: calcium deposition
definition: Pseudoxanthoma elasticum is a progressive disorder characterized by accumulated deposits of calcium and other minerals in elastic fibers.
created by: Paul
creation date: 2011-11-02T07:38:35Z
has_obo_namespace: mouse_pathology.ontology
id: MPATH:780

Axiom
annotated source: pseudoxanthoma elasticum
annotated property: definition
annotated target: Pseudoxanthoma elasticum is a progressive disorder characterized by accumulated deposits of calcium and other minerals in elastic fibers.
database_cross_reference: MPATH:PNS

encephalomalacia
type: Class
subclass of: tissue specific degenerative process
definition: Softening of brain tissue, usually caused by vascular insufficiency or degenerative changes.
created by: Paul
creation date: 2011-11-02T07:43:13Z
has_exact_synonym: cerebromalacia
has_obo_namespace: mouse_pathology.ontology
id: MPATH:781
comment: Areas in the brain where the parenchyma is blanched. Cells in this area are pycnotic. This may be the sequela of an infarction.

Axiom
annotated source: encephalomalacia
annotated property: definition
annotated target: Softening of brain tissue, usually caused by vascular insufficiency or degenerative changes.
database_cross_reference: MPATH:PNS

phthisis bulbi
type: Class
subclass of: tissue specific degenerative process
definition: Collapse of the eye globe associated with degenerative changes.
created by: Paul
creation date: 2011-11-02T07:51:11Z
has_obo_namespace: mouse_pathology.ontology
id: MPATH:782

Axiom
annotated source: phthisis bulbi
annotated property: definition
annotated target: Collapse of the eye globe associated with degenerative changes.
database_cross_reference: MPATH:Sundberg

B6 dermatitis
type: Class
subclass of: dermatitis
definition: Follicular dystrophy, rupture, foreign body reaction, ulceration, scarring, pseudoepitheliomatous hyperplasia are part of a syndrome commonly called B6 dermatitis in black strains of mice.
created by: Paul
creation date: 2011-11-02T07:55:07Z
has_obo_namespace: mouse_pathology.ontology
id: MPATH:783

Axiom
annotated source: B6 dermatitis
annotated property: definition
annotated target: Follicular dystrophy, rupture, foreign body reaction, ulceration, scarring, pseudoepitheliomatous hyperplasia are part of a syndrome commonly called B6 dermatitis in black strains of mice.
database_cross_reference: MPATH:Sundberg

follicular atresia
type: Class
subclass of: tissue specific degenerative process
definition: Degeneration and resorption of an ovarian follicle before it reaches maturity and ruptures.
created by: Paul
creation date: 2011-11-02T07:59:53Z
has_obo_namespace: mouse_pathology.ontology
id: MPATH:784
comment: Included here to permit annotation of unusual patterns or atresia; abnormal numbers of atretic follicles or abnoral size or distribution.

Axiom
annotated source: follicular atresia
annotated property: definition
annotated target: Degeneration and resorption of an ovarian follicle before it reaches maturity and ruptures.
database_cross_reference: MPATH:PNS

bone marrow granulopoiesis
type: Class
subclass of: immunopathological process
definition: Marked production of granulocytes, primarily neutrophils, usually in response to a major acute inflammatory response.
created by: Paul
creation date: 2011-11-02T08:06:16Z
has_obo_namespace: mouse_pathology.ontology
id: MPATH:785

Axiom
annotated source: bone marrow granulopoiesis
annotated property: definition
annotated target: Marked production of granulocytes, primarily neutrophils, usually in response to a major acute inflammatory response.
database_cross_reference: MPATH:Sundberg

inspissation
type: Class
subclass of: general degenerative process
definition: The drying, thickening and coagulation of extracellular secretions or fluids.
created by: Paul
creation date: 2011-11-02T08:09:33Z
has_obo_namespace: mouse_pathology.ontology
id: MPATH:786

Axiom
annotated source: inspissation
annotated property: definition
annotated target: The drying, thickening and coagulation of extracellular secretions or fluids.
database_cross_reference: MPATH:PNS

intervertebral disk prolapse ventral
type: Class
subclass of: intervertebral disk prolapse
definition: Ventral prolapse of the intervertebral disk.
created by: Paul
creation date: 2011-11-02T08:37:59Z
has_obo_namespace: mouse_pathology.ontology
id: MPATH:787
comment: Ventral prolapse is quite rare but found in ageing mice.

Axiom
annotated source: intervertebral disk prolapse ventral
annotated property: definition
annotated target: Ventral prolapse of the intervertebral disk.
database_cross_reference: MPATH:Sundberg

testicular torsion
type: Class
subclass of: torsion
definition: The testicle twisted around the vascular tract to constrict flow resulting in liquifactive necrosis of the affected testicle.
created by: Paul
creation date: 2011-11-02T08:43:39Z
has_obo_namespace: mouse_pathology.ontology
id: MPATH:788

Axiom
annotated source: testicular torsion
annotated property: definition
annotated target: The testicle twisted around the vascular tract to constrict flow resulting in liquifactive necrosis of the affected testicle.
database_cross_reference: MPATH:Sundberg

trichogranuloma
type: Class
subclass of: granuloma
definition: Dermal granuloma surrounding hair fibers.
created by: Paul
creation date: 2011-11-02T08:52:38Z
has_obo_namespace: mouse_pathology.ontology
id: MPATH:789

Axiom
annotated source: trichogranuloma
annotated property: definition
annotated target: Dermal granuloma surrounding hair fibers.
database_cross_reference: MPATH:Sundberg

malposition
type: Class
subclass of: heterotopia
definition: Abnormal position or orientation of a structure insufficient to be called a heterotopia.
has_obo_namespace: mouse_pathology.ontology
has_related_synonym: Misplacement
id: MPATH:79

Axiom
annotated source: malposition
annotated property: definition
annotated target: Abnormal position or orientation of a structure insufficient to be called a heterotopia.
database_cross_reference: Pathbase: Curation

Axiom
annotated source: malposition
annotated property: has_related_synonym
annotated target: Misplacement
database_cross_reference: Pathbase: Curation

bilateral retinal degeneration
type: Class
subclass of: retinal degeneration
definition: Retinal degeneration of both eyes.
created by: Paul
creation date: 2011-11-02T08:56:45Z
has_obo_namespace: mouse_pathology.ontology
id: MPATH:790

Axiom
annotated source: bilateral retinal degeneration
annotated property: definition
annotated target: Retinal degeneration of both eyes.
database_cross_reference: MPATH:Sundberg

cartilagenous embolism
type: Class
subclass of: embolus
definition: Occlusion of a vessel by a piece of dissected cartilage.
created by: Paul
creation date: 2011-11-02T09:27:08Z
has_obo_namespace: mouse_pathology.ontology
id: MPATH:791

Axiom
annotated source: cartilagenous embolism
annotated property: definition
annotated target: Occlusion of a vessel by a piece of dissected cartilage.
database_cross_reference: MPATH:Sundberg

lymph node reticuloendothelial cell hyperplasia
type: Class
subclass of: hyperplastic tissue
definition: Proliferation of the reticuloendothelial cells in the medulla of the lymph node.
created by: Paul
creation date: 2011-11-02T09:32:12Z
has_obo_namespace: mouse_pathology.ontology
id: MPATH:792

Axiom
annotated source: lymph node reticuloendothelial cell hyperplasia
annotated property: definition
annotated target: Proliferation of the reticuloendothelial cells in the medulla of the lymph node.
database_cross_reference: MPATH:Sundberg

reactive splenomegaly
type: Class
subclass of: immunopathological process
definition: An increase in the size of the spleen due to ongoing acute or chronic infection.
created by: Paul
creation date: 2011-11-02T09:42:26Z
has_obo_namespace: mouse_pathology.ontology
id: MPATH:793

Axiom
annotated source: reactive splenomegaly
annotated property: definition
annotated target: An increase in the size of the spleen due to ongoing acute or chronic infection.
database_cross_reference: MPATH:Sundberg

melena
type: Class
subclass of: hemorrhage and non-specified extravasation
definition: Digested blood in the lumen of the stomach or small intestine, indicative of hemorrhage.
created by: Paul
creation date: 2011-11-02T09:57:01Z
has_obo_namespace: mouse_pathology.ontology
id: MPATH:794

Axiom
annotated source: melena
annotated property: definition
annotated target: Digested blood in the lumen of the stomach or small intestine, indicative of hemorrhage.
database_cross_reference: MPATH:Sundberg

psammoma body
type: Class
subclass of: calcium deposition
definition: Round , often laminar, non-proteinaceous eosinophilic bodies representing calcium deposition.
created by: Paul
creation date: 2011-11-02T10:01:09Z
has_obo_namespace: mouse_pathology.ontology
id: MPATH:795
comment: Psammoma bodies are associated with the papillary (nipple-like) histomorphology and are thought to arise from (1) the infarction and calcification of papillae tips and (2) calcification of intralymphatic tumor thrombi.

Axiom
annotated source: psammoma body
annotated property: definition
annotated target: Round , often laminar, non-proteinaceous eosinophilic bodies representing calcium deposition.
database_cross_reference: MPATH:Sundberg

aspermia
type: Class
subclass of: spermatogenesis defect
definition: Lack of sperm.
created by: Paul
creation date: 2011-11-02T10:10:45Z
has_obo_namespace: mouse_pathology.ontology
id: MPATH:796
comment: May be through failure of spermatogenesis, or increased death.

Axiom
annotated source: aspermia
annotated property: definition
annotated target: Lack of sperm.
database_cross_reference: MPATH:Sundberg

spermatogenesis defect
type: Class
subclass of: defective growth and differentiation process
definition: Compromise or abnormality of the process of spermatogenesis
created by: Paul
creation date: 2011-11-02T10:17:11Z
has_obo_namespace: mouse_pathology.ontology
id: MPATH:797

Axiom
annotated source: spermatogenesis defect
annotated property: definition
annotated target: Compromise or abnormality of the process of spermatogenesis
database_cross_reference: MPATH:PNS

hypospermia
type: Class
subclass of: spermatogenesis defect
definition: Reduced numbers of sperm.
created by: Paul
creation date: 2011-11-02T10:18:26Z
has_obo_namespace: mouse_pathology.ontology
id: MPATH:798

Axiom
annotated source: hypospermia
annotated property: definition
annotated target: Reduced numbers of sperm.
database_cross_reference: MPATH:PNS

scoliosis
type: Class
subclass of: spinal structural defects
definition: scoliosis is an abnormal curvature of the spine. The spine curves away from the middle or sideways.
created by: Paul
creation date: 2011-11-02T10:20:56Z
has_obo_namespace: mouse_pathology.ontology
id: MPATH:799

Axiom
annotated source: scoliosis
annotated property: definition
annotated target: scoliosis is an abnormal curvature of the spine. The spine curves away from the middle or sideways.
database_cross_reference: MPATH:Sundberg

fat necrosis
type: Class
subclass of: necrosis
definition: Dead and dying adipose tissue, characterized by the formation of small gray or white foci of soapy (saponified) cellular debris.
has_obo_namespace: mouse_pathology.ontology
id: MPATH:8

Axiom
annotated source: fat necrosis
annotated property: definition
annotated target: Dead and dying adipose tissue, characterized by the formation of small gray or white foci of soapy (saponified) cellular debris.
database_cross_reference: ISBN:0781727286

obstruction and stenosis
type: Class
subclass of: developmental or adult structural defect
definition: Occlusion ( partial or complete) of a lumen or space, internally by a space occupying mass or, in the case of stenosis, by local reduction in the diameter of a vessel, duct or the intestine.
has_obo_namespace: mouse_pathology.ontology
id: MPATH:80

Axiom
annotated source: obstruction and stenosis
annotated property: definition
annotated target: Occlusion ( partial or complete) of a lumen or space, internally by a space occupying mass or, in the case of stenosis, by local reduction in the diameter of a vessel, duct or the intestine.
database_cross_reference: Pathbase: Pathology Committee

intervertebral disk prolapse dorsal
type: Class
subclass of: intervertebral disk prolapse
definition: Dorsal prolapse of the intervertebral disk.
created by: Paul
creation date: 2011-11-03T07:08:38Z
has_obo_namespace: mouse_pathology.ontology
id: MPATH:800

Axiom
annotated source: intervertebral disk prolapse dorsal
annotated property: definition
annotated target: Dorsal prolapse of the intervertebral disk.
database_cross_reference: MPATH:Sundberg

intervertebral disks prolapsed dorsally and ventrally
type: Class
subclass of: intervertebral disk prolapse
definition: Presence of dorsal and ventrally prolapsed disks in the same vertebral column.
created by: Paul
creation date: 2011-11-03T07:09:46Z
has_obo_namespace: mouse_pathology.ontology
id: MPATH:801

Axiom
annotated source: intervertebral disks prolapsed dorsally and ventrally
annotated property: definition
annotated target: Presence of dorsal and ventrally prolapsed disks in the same vertebral column.
database_cross_reference: MPATH:Sundberg

rectal prolapse
type: Class
subclass of: prolapse
definition: Eversion through the anus.
created by: Paul
creation date: 2011-11-03T07:11:38Z
has_obo_namespace: mouse_pathology.ontology
id: MPATH:802

Axiom
annotated source: rectal prolapse
annotated property: definition
annotated target: Eversion through the anus.
database_cross_reference: MPATH:Sundberg

trabecular bone thickening
type: Class
subclass of: growth and differentiation defect
definition: Thickening of trabecular bone.
created by: Paul
creation date: 2011-11-03T07:41:18Z
has_obo_namespace: mouse_pathology.ontology
id: MPATH:803
comment: Not osteopetrosis.

Axiom
annotated source: trabecular bone thickening
annotated property: definition
annotated target: Thickening of trabecular bone.
database_cross_reference: MPATH:Sundberg

cavernous lymphangioma
type: Class
subclass of: lymphangioma
definition: Large numbers of thin-walled dilated lymphatic channels situated in the dermis, subcutis or skeletal muscle.
created by: Paul
creation date: 2011-11-25T03:58:53Z
has_obo_namespace: mouse_pathology.ontology
id: MPATH:804
comment: This is a developmental malformation

Axiom
annotated source: cavernous lymphangioma
annotated property: definition
annotated target: Large numbers of thin-walled dilated lymphatic channels situated in the dermis, subcutis or skeletal muscle.
database_cross_reference: ISBN:0-19-261976-4

cystic hygroma
type: Class
subclass of: lymphangioma
definition: Variant of cavernous lymphangioma (MPATH:804) showing gross dilatation of lymphatic channels.
created by: Paul
creation date: 2011-11-25T04:01:26Z
has_obo_namespace: mouse_pathology.ontology
has_related_synonym: Cystic lymphangioma.
id: MPATH:805

Axiom
annotated source: cystic hygroma
annotated property: definition
annotated target: Variant of cavernous lymphangioma (MPATH:804) showing gross dilatation of lymphatic channels.
database_cross_reference: ISBN:0-19-261976-4

lymphangioma circumscriptum
type: Class
subclass of: lymphangioma
definition: Cutaneous grouped collection of thin-walled translucent vessels, which appear at birth or in early infancy and are commonest around the limb girdles.
created by: Paul
creation date: 2011-11-25T04:03:31Z
has_obo_namespace: mouse_pathology.ontology
id: MPATH:806
comment: Generally believed to represent a developmental defect but may be associated with surgery.

Axiom
annotated source: lymphangioma circumscriptum
annotated property: definition
annotated target: Cutaneous grouped collection of thin-walled translucent vessels, which appear at birth or in early infancy and are commonest around the limb girdles.
database_cross_reference: ISBN:0-19-261976-4

hygroma
type: Class
subclass of: cyst
definition: Large cystic subcutaneous spaces usually found in the flexures, especially around the neck.
created by: Paul
creation date: 2011-11-25T04:11:06Z
has_obo_namespace: mouse_pathology.ontology
has_related_synonym: Cystic hygroma
id: MPATH:807
comment: Obstruction of the developing lymphatics may contribute to their genesis.

Axiom
annotated source: hygroma
annotated property: definition
annotated target: Large cystic subcutaneous spaces usually found in the flexures, especially around the neck.
database_cross_reference: ISBN:0-19-261976-4

lymphedema
type: Class
subclass of: edema
definition: Accumulation of interstitial fluid caused by blockage or failure of the lymphatic system.
created by: Paul
creation date: 2011-11-25T04:15:32Z
has_exact_synonym: Lymphoedema
has_obo_namespace: mouse_pathology.ontology
id: MPATH:808
comment: Not be confused with edema arising from venous insufficiency, which is not lymphedema.

Axiom
annotated source: lymphedema
annotated property: definition
annotated target: Accumulation of interstitial fluid caused by blockage or failure of the lymphatic system.
database_cross_reference: ISBN:0-19-261976-4

nuchal edema
type: Class
subclass of: edema
definition: Edema of the posterior aspect of the fetal neck caused by an accumulation of fluid, usually lymph.
created by: Paul
creation date: 2011-11-25T04:33:15Z
has_obo_namespace: mouse_pathology.ontology
id: MPATH:809

Axiom
annotated source: nuchal edema
annotated property: definition
annotated target: Edema of the posterior aspect of the fetal neck caused by an accumulation of fluid, usually lymph.
database_cross_reference: MPATH:Pathology committee

perforation
type: Class
subclass of: developmental or adult structural defect
definition: Presence of a hole/channel through a normally imperforate structure often a membrane or septum.
has_obo_namespace: mouse_pathology.ontology
id: MPATH:81

Axiom
annotated source: perforation
annotated property: definition
annotated target: Presence of a hole/channel through a normally imperforate structure often a membrane or septum.
database_cross_reference: Pathbase: Pathology Committee

follicular dystrophy
type: Class
subclass of: dystrophy
definition: Degenerative changes in hair follicles resulting in a deformed hair fiber, sometimes root sheath hyperplasia and follicular rupture.
created by: Paul
creation date: 2011-11-25T05:04:59Z
has_obo_namespace: mouse_pathology.ontology
id: MPATH:810

Axiom
annotated source: follicular dystrophy
annotated property: definition
annotated target: Degenerative changes in hair follicles resulting in a deformed hair fiber, sometimes root sheath hyperplasia and follicular rupture.
database_cross_reference: MPATH:Sundberg

epicardial mineralization
type: Class
subclass of: mineralisation
definition: Deposition of minerals in the epicardium.
created by: Paul
creation date: 2012-03-19T03:53:35Z
has_obo_namespace: mouse_pathology.ontology
id: MPATH:811

Axiom
annotated source: epicardial mineralization
annotated property: definition
annotated target: Deposition of minerals in the epicardium.
database_cross_reference: MPATH:curation

blister
type: Class
subclass of: cell and tissue damage
definition: A collection of fluid underneath the top layer of skin (epidermis).
created by: Paul
creation date: 2012-03-19T03:59:12Z
has_obo_namespace: mouse_pathology.ontology
id: MPATH:812
comment: Most blisters are filled with a clear fluid called serum or plasma. However, blisters can be filled with blood (known as blood blisters) or with pus (if they become infected).

Axiom
annotated source: blister
annotated property: definition
annotated target: A collection of fluid underneath the top layer of skin (epidermis).
database_cross_reference: MPATH:curation

epidermolysis bullosa lesions
type: Class
subclass of: blister
definition: Lesions of a connective tissue disease causing blisters in the skin and mucosal membranes.
created by: Paul
creation date: 2012-03-19T04:02:20Z
has_obo_namespace: mouse_pathology.ontology
id: MPATH:813

Axiom
annotated source: epidermolysis bullosa lesions
annotated property: definition
annotated target: Lesions of a connective tissue disease causing blisters in the skin and mucosal membranes.
database_cross_reference: MPATH:curation

focal hepatic lipidosis
type: Class
subclass of: steatosis
definition: Locally circumscribed regions of fatty change.
created by: Paul
creation date: 2012-03-19T04:10:23Z
has_exact_synonym: focal fatty change
has_obo_namespace: mouse_pathology.ontology
id: MPATH:814

Axiom
annotated source: focal hepatic lipidosis
annotated property: definition
annotated target: Locally circumscribed regions of fatty change.
database_cross_reference: MPATH:curation

macrovesicular lipidosis
type: Class
subclass of: steatosis
definition: subtype of steatosis with Hepatocytes containing a large well-defined single rounded vacuole within each cell, nucleus and cytoplasm displaced to the periphery,
created by: Paul
creation date: 2012-03-19T04:13:31Z
has_exact_synonym: macrovesicular steatosis
has_obo_namespace: mouse_pathology.ontology
id: MPATH:815

Axiom
annotated source: macrovesicular lipidosis
annotated property: definition
annotated target: subtype of steatosis with Hepatocytes containing a large well-defined single rounded vacuole within each cell, nucleus and cytoplasm displaced to the periphery,
database_cross_reference: PMID: 21191096

microvesicular lipidosis
type: Class
subclass of: steatosis
definition: Variant form of hepatic steatosis. Hepatocytes partially or completely filled with numerous small lipid vacuoles. Affected hepatocytes may have a foamy appearance.Small vacuoles do not normally displace the nucleus to the periphery in contrast to macrovesicular lipidosis.
created by: Paul
creation date: 2012-03-19T04:18:42Z
has_exact_synonym: microvesicular fatty change
has_exact_synonym: microvesicular steatosis
has_obo_namespace: mouse_pathology.ontology
id: MPATH:816

Axiom
annotated source: microvesicular lipidosis
annotated property: definition
annotated target: Variant form of hepatic steatosis. Hepatocytes partially or completely filled with numerous small lipid vacuoles. Affected hepatocytes may have a foamy appearance.Small vacuoles do not normally displace the nucleus to the periphery in contrast to macrovesicular lipidosis.
database_cross_reference: PMID:21191096

hydropic degeneration
type: Class
subclass of: general degenerative process
definition: Form of degenerative process in which there is Intracytoplasmic fluid accumulation secondary to disturbance of cell membrane integrity.
created by: Paul
creation date: 2012-03-19T04:26:38Z
has_exact_synonym: cloudy swelling
has_exact_synonym: hydropic change
has_obo_namespace: mouse_pathology.ontology
has_related_synonym: <new synonym>
id: MPATH:817
comment: Cytoplasmic vacuolation and ballooning with a centrally located nucleus.

Axiom
annotated source: hydropic degeneration
annotated property: definition
annotated target: Form of degenerative process in which there is Intracytoplasmic fluid accumulation secondary to disturbance of cell membrane integrity.
database_cross_reference: MPATH:curation

focal pulmonary histiocytosis
type: Class
subclass of: histiocytosis
created by: Paul
creation date: 2012-03-19T04:37:02Z
has_obo_namespace: mouse_pathology.ontology
id: MPATH:818

focal renal pelvic mineralisation.
type: Class
subclass of: mineralisation
created by: Paul
creation date: 2012-03-19T04:39:04Z
has_obo_namespace: mouse_pathology.ontology
id: MPATH:819

persistent embryonic structure
type: Class
subclass of: developmental or adult structural defect
definition: Persistence of an embryonic structure or tissue into the post-natal period in its normal location; (Chronological/temporal anomaly).
has_obo_namespace: mouse_pathology.ontology
has_related_synonym: Embryonic rest.
id: MPATH:82

Axiom
annotated source: persistent embryonic structure
annotated property: definition
annotated target: Persistence of an embryonic structure or tissue into the post-natal period in its normal location; (Chronological/temporal anomaly).
database_cross_reference: Pathbase: Pathology Committee

Axiom
annotated source: persistent embryonic structure
annotated property: has_related_synonym
annotated target: Embryonic rest.
database_cross_reference: Pathbase: Curation

goitre
type: Class
subclass of: hyperplastic tissue
definition: Increase in size of the thyroid gland caused initially by uniform follicular epithelial hyperplasia generally in response to iodine deficiency.
created by: Paul
creation date: 2012-03-19T05:09:58Z
has_exact_synonym: goiter
has_obo_namespace: mouse_pathology.ontology
has_related_synonym: hyperplastic goitre
id: MPATH:820

Axiom
annotated source: goitre
annotated property: definition
annotated target: Increase in size of the thyroid gland caused initially by uniform follicular epithelial hyperplasia generally in response to iodine deficiency.
database_cross_reference: MPATH:curation

hypoplastic tissue
type: Class
subclass of: growth and differentiation defect
definition: Tissue showing smaller mass as a consequence of deficient proliferation or premature differentiation.
created by: Paul
creation date: 2012-03-19T05:20:21Z
has_obo_namespace: mouse_pathology.ontology
id: MPATH:821

Axiom
annotated source: hypoplastic tissue
annotated property: definition
annotated target: Tissue showing smaller mass as a consequence of deficient proliferation or premature differentiation.
database_cross_reference: MPATH:curation

hypoplastic gut associated lymphoid tissue
type: Class
subclass of: hypoplastic tissue
definition: Reduced mass of GALT resulting form fewer cells.
created by: Paul
creation date: 2012-03-19T05:21:50Z
has_obo_namespace: mouse_pathology.ontology
id: MPATH:822

Axiom
annotated source: hypoplastic gut associated lymphoid tissue
annotated property: definition
annotated target: Reduced mass of GALT resulting form fewer cells.
database_cross_reference: MPATH:curation

myxofibroma
type: Class
subclass of: fibroma
definition: A benign neoplasm characterized by mucous and fibroblastic tissues.
created by: Paul
creation date: 2012-03-20T11:45:41Z
has_exact_synonym: Fibromyxoma
has_obo_namespace: mouse_pathology.ontology
has_related_synonym: fibroma myxomatodes.
id: MPATH:823

Axiom
annotated source: myxofibroma
annotated property: definition
annotated target: A benign neoplasm characterized by mucous and fibroblastic tissues.
database_cross_reference: MPATH:curation

myofibroma
type: Class
subclass of: fibroma
definition: A benign localized neoplasm arising from the subcutaneous tissues and skeletal muscle. It is characterized by the presence of myofibroblastic hyperchromatic spindle cells, hylanized stroma formation, calcification, necrosis, and a multinodular growth pattern.
created by: Paul
creation date: 2012-03-20T11:51:59Z
has_obo_namespace: mouse_pathology.ontology
has_related_synonym: Solitary Myofibromatosis
id: MPATH:824

Axiom
annotated source: myofibroma
annotated property: definition
annotated target: A benign localized neoplasm arising from the subcutaneous tissues and skeletal muscle. It is characterized by the presence of myofibroblastic hyperchromatic spindle cells, hylanized stroma formation, calcification, necrosis, and a multinodular growth pattern.
database_cross_reference: CUI:C1266121

vacuolation
type: Class
subclass of: general degenerative process
definition: Generation of intracytoplasmic vacuoles otherwise unspecified.
created by: Paul
creation date: 2012-03-22T08:19:10Z
has_obo_namespace: mouse_pathology.ontology
id: MPATH:825

Axiom
annotated source: vacuolation
annotated property: definition
annotated target: Generation of intracytoplasmic vacuoles otherwise unspecified.
database_cross_reference: MPATH:curation

granulomatous dermatitis
type: Class
subclass of: granulomatous inflammation
definition: granulomatous inflammation of the skin
created by: Paul
creation date: 2012-03-22T08:22:17Z
has_obo_namespace: mouse_pathology.ontology
id: MPATH:826

Axiom
annotated source: granulomatous dermatitis
annotated property: definition
annotated target: granulomatous inflammation of the skin
database_cross_reference: MPATH:curation

chronic dermatitis
type: Class
subclass of: chronic inflammation
definition: chronic inflammation of the skin
created by: Paul
creation date: 2012-03-22T08:24:43Z
has_obo_namespace: mouse_pathology.ontology
id: MPATH:827

Axiom
annotated source: chronic dermatitis
annotated property: definition
annotated target: chronic inflammation of the skin
database_cross_reference: MPATH:curation

focal dermatitis
type: Class
subclass of: dermatitis
definition: locally demarcated region of inflammation in the skin
created by: Paul
creation date: 2012-03-22T08:33:42Z
has_obo_namespace: mouse_pathology.ontology
id: MPATH:828

Axiom
annotated source: focal dermatitis
annotated property: definition
annotated target: locally demarcated region of inflammation in the skin
database_cross_reference: MPATH:curation

true hermaphrodite
type: Class
subclass of: organ specific developmental defect
definition: possession of both ovary and testis due to primary sex determination defect
created by: Paul
creation date: 2012-03-22T08:42:35Z
has_obo_namespace: mouse_pathology.ontology
id: MPATH:829

Axiom
annotated source: true hermaphrodite
annotated property: definition
annotated target: possession of both ovary and testis due to primary sex determination defect
database_cross_reference: MPATH:curation

septation defect
type: Class
subclass of: developmental or adult structural defect
definition: Any defect in the formation of septae not describable as perforation.
has_obo_namespace: mouse_pathology.ontology
id: MPATH:83

Axiom
annotated source: septation defect
annotated property: definition
annotated target: Any defect in the formation of septae not describable as perforation.
database_cross_reference: Pathbase: Curation

regeneration
type: Class
subclass of: defective growth and differentiation process
definition: repair, reproduction, or replacement of lost or injured cells, tissues, or organs.
created by: Paul
creation date: 2012-03-22T08:45:44Z
has_obo_namespace: mouse_pathology.ontology
id: MPATH:830

Axiom
annotated source: regeneration
annotated property: definition
annotated target: repair, reproduction, or replacement of lost or injured cells, tissues, or organs.
database_cross_reference: MPATH:curation

multifocal muscle regeneration
type: Class
subclass of: regeneration
definition: multilocular sites of muscle regeneration with centrally located nuclei.
created by: Paul
creation date: 2012-03-22T08:48:14Z
has_obo_namespace: mouse_pathology.ontology
id: MPATH:831

Axiom
annotated source: multifocal muscle regeneration
annotated property: definition
annotated target: multilocular sites of muscle regeneration with centrally located nuclei.
database_cross_reference: MPATH:curation

paraphimosis
type: Class
subclass of: developmental or adult structural defect
definition: persistent retraction of the prepuce behind the glans penis
created by: Paul
creation date: 2012-03-22T08:52:08Z
has_obo_namespace: mouse_pathology.ontology
id: MPATH:832
comment: generally due to inflammation, but can cause further inflammation which exacerbates the condition

Axiom
annotated source: paraphimosis
annotated property: definition
annotated target: persistent retraction of the prepuce behind the glans penis
database_cross_reference: MPATH:curation

subacute inflammation
type: Class
subclass of: inflammation
definition: transition between acute and chronic inflammation.
created by: Paul
creation date: 2012-03-22T08:55:14Z
has_obo_namespace: mouse_pathology.ontology
id: MPATH:833
comment: time varies form a few days to a week or so. Cells mainly lymphocytes and plasma cells, few macrophages or neutrophils. Less hemorrhage, edema and hyperemia.

Axiom
annotated source: subacute inflammation
annotated property: definition
annotated target: transition between acute and chronic inflammation.
database_cross_reference: mpath:curation

ovarian tubulostromal tumor
type: Class
subclass of: potentially cancerous lesions
definition: non-malignant neoplasia of the ovary.
created by: Paul
creation date: 2012-03-22T09:04:54Z
has_obo_namespace: mouse_pathology.ontology
has_related_synonym: tubular adenoma
id: MPATH:834

Axiom
annotated source: ovarian tubulostromal tumor
annotated property: definition
annotated target: non-malignant neoplasia of the ovary.
database_cross_reference: ISBN:0-944398-45-6
database_cross_reference: MPATH:curation

acute septic inflammation
type: Class
subclass of: acute inflammation
definition: acute inflammation due to infection.
created by: Paul
creation date: 2012-03-22T03:38:07Z
has_obo_namespace: mouse_pathology.ontology
id: MPATH:835

Axiom
annotated source: acute septic inflammation
annotated property: definition
annotated target: acute inflammation due to infection.
database_cross_reference: MPATH:curation

dermal fibrosis
type: Class
subclass of: fibrosis
definition: fibrosis in the skin
created by: Paul
creation date: 2012-03-22T05:06:25Z
has_obo_namespace: mouse_pathology.ontology
id: MPATH:836

Axiom
annotated source: dermal fibrosis
annotated property: definition
annotated target: fibrosis in the skin
database_cross_reference: MPATH:curation

hepatic mid-zonal fatty metamorphosis
type: Class
subclass of: steatosis
definition: Fatty change in the mid-zonal region of the liver.
created by: Paul
creation date: 2012-03-22T05:23:46Z
has_obo_namespace: mouse_pathology.ontology
id: MPATH:837

Axiom
annotated source: hepatic mid-zonal fatty metamorphosis
annotated property: definition
annotated target: Fatty change in the mid-zonal region of the liver.
database_cross_reference: MPATH:curation

anaplastic carcinoma
type: Class
subclass of: carcinoma
definition: carcinoma with an absence of epithelial structural differentiation.
created by: Paul
creation date: 2012-03-22T05:26:31Z
has_obo_namespace: mouse_pathology.ontology
id: MPATH:838

Axiom
annotated source: anaplastic carcinoma
annotated property: definition
annotated target: carcinoma with an absence of epithelial structural differentiation.
database_cross_reference: MPATH:curation

anaplastic hepatocellular carcinoma
type: Class
subclass of: hepatocellular carcinoma
subclass of: anaplastic carcinoma
definition: anaplastic carcinoma of the liver.
created by: Paul
creation date: 2012-03-22T05:28:22Z
has_obo_namespace: mouse_pathology.ontology
id: MPATH:839

Axiom
annotated source: anaplastic hepatocellular carcinoma
annotated property: definition
annotated target: anaplastic carcinoma of the liver.
database_cross_reference: MPATH:curation

supernumerary structure
type: Class
subclass of: displacement and deformity
definition: Additional structure whether normally located or not.
has_obo_namespace: mouse_pathology.ontology
id: MPATH:84

Axiom
annotated source: supernumerary structure
annotated property: definition
annotated target: Additional structure whether normally located or not.
database_cross_reference: Pathbase: Curation

granulomatous arthritis
type: Class
subclass of: arthritis
subclass of: granulomatous inflammation
definition: arthitis involving extensive macrophage infiltration into the joint.
created by: Paul
creation date: 2012-03-22T05:37:23Z
has_obo_namespace: mouse_pathology.ontology
id: MPATH:840

Axiom
annotated source: granulomatous arthritis
annotated property: definition
annotated target: arthitis involving extensive macrophage infiltration into the joint.
database_cross_reference: MPATH:curation

anopthalmia
type: Class
subclass of: organ specific developmental defect
definition: Absence of eye.
created by: Paul
creation date: 2012-03-22T05:40:44Z
has_obo_namespace: mouse_pathology.ontology
id: MPATH:841
comment: may be uni or bilateral

Axiom
annotated source: anopthalmia
annotated property: definition
annotated target: Absence of eye.
database_cross_reference: MPATH:curation

coccygeal hemivertebrae
type: Class
subclass of: displacement and deformity
definition: abnormally shaped vertebral body often triangular as opposed to rectangular.
created by: Paul
creation date: 2012-03-22T05:55:21Z
has_obo_namespace: mouse_pathology.ontology
id: MPATH:842
comment: spontaneous or induced developmental lesion

Axiom
annotated source: coccygeal hemivertebrae
annotated property: definition
annotated target: abnormally shaped vertebral body often triangular as opposed to rectangular.
database_cross_reference: PMID:1666161

stasis
type: Class
subclass of: obstruction and stenosis
definition: Cessation of movement of a body fluid or liquid.
created by: Paul
creation date: 2012-03-22T06:05:28Z
has_obo_namespace: mouse_pathology.ontology
id: MPATH:843

Axiom
annotated source: stasis
annotated property: definition
annotated target: Cessation of movement of a body fluid or liquid.
database_cross_reference: MPATH:curation

biliary stasis
type: Class
subclass of: stasis
definition: Cessation of the flow of bile due to bile duct blockage or overproduction.
created by: Paul
creation date: 2012-03-22T06:06:41Z
has_obo_namespace: mouse_pathology.ontology
id: MPATH:844

Axiom
annotated source: biliary stasis
annotated property: definition
annotated target: Cessation of the flow of bile due to bile duct blockage or overproduction.
database_cross_reference: MPATH:curation

partial abortion
type: Class
subclass of: placental abnormality
definition: Evidence of residual placenta in utero without embryo.
created by: Paul
creation date: 2012-03-24T03:03:26Z
has_obo_namespace: mouse_pathology.ontology
id: MPATH:845

Axiom
annotated source: partial abortion
annotated property: definition
annotated target: Evidence of residual placenta in utero without embryo.
database_cross_reference: MPATH:curation

foreign body acute pododermatitis
type: Class
subclass of: foreign body dermatitis
definition: acute inflammation of the footpad caused by foreign body.
created by: Paul
creation date: 2012-03-24T03:05:46Z
has_obo_namespace: mouse_pathology.ontology
id: MPATH:846

Axiom
annotated source: foreign body acute pododermatitis
annotated property: definition
annotated target: acute inflammation of the footpad caused by foreign body.
database_cross_reference: MPATH:curation

granuloma
type: Class
subclass of: granulomatous inflammation
definition: Collection of epithelioid macrophages into a nodule
created by: Paul
creation date: 2012-03-24T03:19:38Z
has_obo_namespace: mouse_pathology.ontology
id: MPATH:847

Axiom
annotated source: granuloma
annotated property: definition
annotated target: Collection of epithelioid macrophages into a nodule
database_cross_reference: MPATH:curation

effacing granuloma
type: Class
subclass of: granuloma
definition: Replacement of normal tissue by granuloma.
created by: Paul
creation date: 2012-03-24T03:22:52Z
has_obo_namespace: mouse_pathology.ontology
id: MPATH:848

Axiom
annotated source: effacing granuloma
annotated property: definition
annotated target: Replacement of normal tissue by granuloma.
database_cross_reference: MPATH:curation

anaplastic mammary adenocarcinoma
type: Class
subclass of: adenocarcinoma
definition: poorly differentiated adenocarcinoma of the mammary gland
created by: Paul
creation date: 2012-03-24T03:26:01Z
has_obo_namespace: mouse_pathology.ontology
id: MPATH:849

Axiom
annotated source: anaplastic mammary adenocarcinoma
annotated property: definition
annotated target: poorly differentiated adenocarcinoma of the mammary gland
database_cross_reference: MPATH:curation

transdifferentiation
type: Class
subclass of: developmental process abnormalities
definition: Alteration in the differentiation of a cell or tissue already showing a different, recognisable, differentiated state.
has_obo_namespace: mouse_pathology.ontology
id: MPATH:85
comment: This term is generally used in the context of embryonic cells or stem cells.

Axiom
annotated source: transdifferentiation
annotated property: definition
annotated target: Alteration in the differentiation of a cell or tissue already showing a different, recognisable, differentiated state.
database_cross_reference: Pathbase: Pathology Committee

post-traumatic structural abnormality
type: Class
subclass of: developmental or adult structural defect
definition: Morphological abnormality following trauma or related insult such as infection.
created by: Paul
creation date: 2012-03-24T03:28:03Z
has_obo_namespace: mouse_pathology.ontology
id: MPATH:850

Axiom
annotated source: post-traumatic structural abnormality
annotated property: definition
annotated target: Morphological abnormality following trauma or related insult such as infection.
database_cross_reference: MPATH:curation

auricular deformation
type: Class
subclass of: post-traumatic structural abnormality
definition: acquired dysmorphology of the external pinna following trauma or infection.
created by: Paul
creation date: 2012-03-24T03:29:48Z
has_obo_namespace: mouse_pathology.ontology
id: MPATH:851

Axiom
annotated source: auricular deformation
annotated property: definition
annotated target: acquired dysmorphology of the external pinna following trauma or infection.
database_cross_reference: MPATH:curation

plasmacytosis
type: Class
subclass of: immune mediated disease
definition: A condition in which there is an unusually large proportion of plasma cells in tissues, exudates, or blood.
created by: Paul
creation date: 2012-03-24T03:32:23Z
has_obo_namespace: mouse_pathology.ontology
id: MPATH:852

Axiom
annotated source: plasmacytosis
annotated property: definition
annotated target: A condition in which there is an unusually large proportion of plasma cells in tissues, exudates, or blood.
database_cross_reference: MPAHTH:curation

systemic plasmacytosis
type: Class
subclass of: plasmacytosis
definition: Abnormality of circulating plasma cells
created by: Paul
creation date: 2012-03-24T03:33:57Z
has_obo_namespace: mouse_pathology.ontology
id: MPATH:853

Axiom
annotated source: systemic plasmacytosis
annotated property: definition
annotated target: Abnormality of circulating plasma cells
database_cross_reference: MPATH:curation

cutaneous plasmacytosis
type: Class
subclass of: plasmacytosis
definition: Plasmacytosis in the skin.
created by: Paul
creation date: 2012-03-24T03:35:42Z
has_obo_namespace: mouse_pathology.ontology
id: MPATH:854

Axiom
annotated source: cutaneous plasmacytosis
annotated property: definition
annotated target: Plasmacytosis in the skin.
database_cross_reference: MPATH:curation

Splendore-Hoeppli phenomenon
type: Class
subclass of: immune mediated disease
definition: In vivo formation of intensely eosinophilic material (radiate, star-like, asteroid or club-shaped configurations) around microorganisms (fungi, bacteria and parasites) or biologically inert substances.
created by: Paul
creation date: 2012-03-24T03:38:37Z
has_obo_namespace: mouse_pathology.ontology
id: MPATH:855

Axiom
annotated source: Splendore-Hoeppli phenomenon
annotated property: definition
annotated target: In vivo formation of intensely eosinophilic material (radiate, star-like, asteroid or club-shaped configurations) around microorganisms (fungi, bacteria and parasites) or biologically inert substances.
database_cross_reference: PMID:18976399

bullous emphysema
type: Class
subclass of: emphysema
definition: Rupture of alveolar walls result in large rounded open air spaces in the lung
created by: Paul
creation date: 2012-03-24T03:43:52Z
has_obo_namespace: mouse_pathology.ontology
id: MPATH:856

Axiom
annotated source: bullous emphysema
annotated property: definition
annotated target: Rupture of alveolar walls result in large rounded open air spaces in the lung
database_cross_reference: MPATH:curation

multifocal bullous emphysema
type: Class
subclass of: bullous emphysema
definition: mutilocular bullous emphysema
created by: Paul
creation date: 2012-03-24T03:45:01Z
has_obo_namespace: mouse_pathology.ontology
id: MPATH:857

Axiom
annotated source: multifocal bullous emphysema
annotated property: definition
annotated target: mutilocular bullous emphysema
database_cross_reference: MPATH:curation

capillary hemangioma
type: Class
subclass of: hemangioma
definition: Benign proliferation of capillaries made up of closely packed aggregations of capillaries, usually of normal caliber, separated by scant connective stroma.
created by: Paul
creation date: 2012-03-24T03:46:38Z
has_obo_namespace: mouse_pathology.ontology
id: MPATH:858
comment: Most common kind of hemangioma thought to be derived from primitive mesenchymal stem cells.

Axiom
annotated source: capillary hemangioma
annotated property: definition
annotated target: Benign proliferation of capillaries made up of closely packed aggregations of capillaries, usually of normal caliber, separated by scant connective stroma.
database_cross_reference: MPATH:curation

botryomycosis
type: Class
subclass of: pyogranulomatous inflammation
definition: Chronic granulomatous bacterial infection that affects the skin, and sometimes the viscera. Usually caused by S. aureus.
created by: Paul
creation date: 2012-03-24T03:52:35Z
has_obo_namespace: mouse_pathology.ontology
id: MPATH:859

Axiom
annotated source: botryomycosis
annotated property: definition
annotated target: Chronic granulomatous bacterial infection that affects the skin, and sometimes the viscera. Usually caused by S. aureus.
database_cross_reference: ISBN: 0-7216-2921-0.

organ specific developmental defect
type: Class
subclass of: developmental and structural abnormality
definition: Developmental defect characteristic of a particular organ or organ system which may be a recognised syndrome or a complex defect showing multiple manifestations.
has_obo_namespace: mouse_pathology.ontology
id: MPATH:86

Axiom
annotated source: organ specific developmental defect
annotated property: definition
annotated target: Developmental defect characteristic of a particular organ or organ system which may be a recognised syndrome or a complex defect showing multiple manifestations.
database_cross_reference: Pathbase: Curation

cholecystitis
type: Class
subclass of: inflammation
definition: inflammation of the gall bladder
created by: Paul
creation date: 2012-03-24T04:11:00Z
has_obo_namespace: mouse_pathology.ontology
id: MPATH:860

Axiom
annotated source: cholecystitis
annotated property: definition
annotated target: inflammation of the gall bladder
database_cross_reference: MPATH:curation

edematous cholecystitis
type: Class
subclass of: cholecystitis
definition: cholecystitis associated with edema
created by: Paul
creation date: 2012-03-24T04:11:43Z
has_obo_namespace: mouse_pathology.ontology
id: MPATH:861

Axiom
annotated source: edematous cholecystitis
annotated property: definition
annotated target: cholecystitis associated with edema
database_cross_reference: MPATH:curation

flatus
type: Class
subclass of: intracellular and extracellular accumulation
definition: Accumulation or trapping of air
created by: Paul
creation date: 2012-03-24T04:17:10Z
has_obo_namespace: mouse_pathology.ontology
id: MPATH:862

Axiom
annotated source: flatus
annotated property: definition
annotated target: Accumulation or trapping of air
database_cross_reference: MPATH:curation

focal ulcerative dermatitis
type: Class
subclass of: dermatitis
definition: circumscribed ulceration of the skin penetrating the basement membrane as part of inflammation process.
created by: Paul
creation date: 2012-03-24T04:18:54Z
has_obo_namespace: mouse_pathology.ontology
id: MPATH:863

Axiom
annotated source: focal ulcerative dermatitis
annotated property: definition
annotated target: circumscribed ulceration of the skin penetrating the basement membrane as part of inflammation process.
database_cross_reference: MPATH:curation

otitis externa
type: Class
subclass of: inflammation
definition: Inflammation of the outer ear.
created by: Paul
creation date: 2012-03-25T10:00:59Z
has_obo_namespace: mouse_pathology.ontology
id: MPATH:864

Axiom
annotated source: otitis externa
annotated property: definition
annotated target: Inflammation of the outer ear.
database_cross_reference: MPATH:curation

foreign body acute papillomatous glossitis
type: Class
subclass of: foreign body glossitis
definition: Papillomatous inflammation of the tongue caused by a foreign body.
created by: Paul
creation date: 2012-03-25T10:49:17Z
has_obo_namespace: mouse_pathology.ontology
id: MPATH:865

Axiom
annotated source: foreign body acute papillomatous glossitis
annotated property: definition
annotated target: Papillomatous inflammation of the tongue caused by a foreign body.
database_cross_reference: MPATH:curationf>

gastric adenomatous hyperplasia
type: Class
subclass of: epithelial hyperplasia
definition: Thickening of the glandular epithelium
created by: Paul
creation date: 2012-03-25T10:59:20Z
has_obo_namespace: mouse_pathology.ontology
id: MPATH:866
comment: Often with crystalloid formation

Axiom
annotated source: gastric adenomatous hyperplasia
annotated property: definition
annotated target: Thickening of the glandular epithelium
database_cross_reference: MPATH:curation

hepatic central vein perivascular fibrosis
type: Class
subclass of: fibrosis
definition: Major hepatic vein surrounded by fibrous connective tissue.
created by: Paul
creation date: 2012-03-25T11:02:20Z
has_obo_namespace: mouse_pathology.ontology
id: MPATH:867

Axiom
annotated source: hepatic central vein perivascular fibrosis
annotated property: definition
annotated target: Major hepatic vein surrounded by fibrous connective tissue.
database_cross_reference: MPATH:curation

uterine ectasia
type: Class
subclass of: ectasia
definition: Dilation of the uterus
created by: Paul
creation date: 2012-03-25T11:58:56Z
has_obo_namespace: mouse_pathology.ontology
has_related_synonym: hydrometra
id: MPATH:868
comment: Usually assciated iwth hydrpometra

Axiom
annotated source: uterine ectasia
annotated property: definition
annotated target: Dilation of the uterus
database_cross_reference: MPATH:curation

intussception
type: Class
subclass of: developmental or adult structural defect
definition: Condition in which a part of the intestine has invaginated into another section of intestine,
created by: Paul
creation date: 2012-03-25T12:04:33Z
has_obo_namespace: mouse_pathology.ontology
id: MPATH:869

Axiom
annotated source: intussception
annotated property: definition
annotated target: Condition in which a part of the intestine has invaginated into another section of intestine,
database_cross_reference: MPATH:curation

germ cell defect
type: Class
subclass of: organ specific developmental defect
definition: Abnormal morphology, differentiation or location of primordial germ cells or their descendents. Not neoplastic.
has_obo_namespace: mouse_pathology.ontology
id: MPATH:87

Axiom
annotated source: germ cell defect
annotated property: definition
annotated target: Abnormal morphology, differentiation or location of primordial germ cells or their descendents. Not neoplastic.
database_cross_reference: Pathbase: Curation

junctional epidermolysis bullosa
type: Class
subclass of: epidermolysis bullosa lesions
definition: severe type of the disorder generally apparent at birth.Junctional epidermolysis bullosa involves defects in hemidesmosomes. t
created by: Paul
creation date: 2012-03-25T12:10:57Z
has_obo_namespace: mouse_pathology.ontology
id: MPATH:870

Axiom
annotated source: junctional epidermolysis bullosa
annotated property: definition
annotated target: severe type of the disorder generally apparent at birth.Junctional epidermolysis bullosa involves defects in hemidesmosomes. t
database_cross_reference: MPATH:curation

spinal structural defects
type: Class
subclass of: organ specific developmental defect
definition: Structural defects of the bony and muscular components of the vertebrae.
created by: Paul
creation date: 2012-03-25T12:15:53Z
has_obo_namespace: mouse_pathology.ontology
id: MPATH:871

Axiom
annotated source: spinal structural defects
annotated property: definition
annotated target: Structural defects of the bony and muscular components of the vertebrae.
database_cross_reference: MPATH:curation

kyphosis
type: Class
subclass of: spinal structural defects
definition: Abnormality of the kyphotic curvature of the spine.
created by: Paul
creation date: 2012-03-25T12:17:10Z
has_obo_namespace: mouse_pathology.ontology
id: MPATH:872

Axiom
annotated source: kyphosis
annotated property: definition
annotated target: Abnormality of the kyphotic curvature of the spine.
database_cross_reference: MPATH:curation

micropthalmia
type: Class
subclass of: abnormal organ size
definition: Reduced size of the eye globe.
created by: Paul
creation date: 2012-03-25T12:21:30Z
has_obo_namespace: mouse_pathology.ontology
id: MPATH:873

Axiom
annotated source: micropthalmia
annotated property: definition
annotated target: Reduced size of the eye globe.
database_cross_reference: MPATH:curation

plasmacytosis
type: Class
subclass of: hyperplastic tissue
definition: Plasmacytosis is a hyperplastic condition in which there is an unusually large proportion of mature plasma cells in tissues, exudates, or blood.
created by: Paul
creation date: 2012-09-03T04:32:06Z
has_obo_namespace: mouse_pathology.ontology
id: MPATH:874

Axiom
annotated source: plasmacytosis
annotated property: definition
annotated target: Plasmacytosis is a hyperplastic condition in which there is an unusually large proportion of mature plasma cells in tissues, exudates, or blood.
database_cross_reference: MPATH:Pathology Committee

cutaneous plasmacytosis
type: Class
subclass of: plasmacytosis
definition: cutaneous manifestation of plasmacytosis
created by: Paul
creation date: 2012-09-03T04:36:31Z
has_obo_namespace: mouse_pathology.ontology
id: MPATH:875

Axiom
annotated source: cutaneous plasmacytosis
annotated property: definition
annotated target: cutaneous manifestation of plasmacytosis
database_cross_reference: MPATH:Pathology Committee

systemic plasmacytosis
type: Class
subclass of: plasmacytosis
definition: systemic manifestation of plasmacytosis. Disseminated in the circulation.
created by: Paul
creation date: 2012-09-03T04:37:32Z
has_obo_namespace: mouse_pathology.ontology
id: MPATH:876

Axiom
annotated source: systemic plasmacytosis
annotated property: definition
annotated target: systemic manifestation of plasmacytosis. Disseminated in the circulation.
database_cross_reference: MPATH:Pathology Committee

pneumonia
type: Class
subclass of: inflammation
definition: An inflammatory condition of the lung, especially affecting the alveoli, associated with fever, chest symptoms, and congestion.
created by: Paul
creation date: 2012-09-03T05:30:23Z
has_obo_namespace: mouse_pathology.ontology
id: MPATH:877
comment: Typically caused by an infection but there are a number of other causes. Infectious agents include: bacteria, viruses, fungi, and parasites.

Axiom
annotated source: pneumonia
annotated property: definition
annotated target: An inflammatory condition of the lung, especially affecting the alveoli, associated with fever, chest symptoms, and congestion.
database_cross_reference: http://en.wikipedia.org/wiki/Pneumonia

foreign body aspiration pneumonia
type: Class
subclass of: pneumonia
definition: Pneumonia caused by aspiration of a foreign body.
created by: Paul
creation date: 2012-09-03T05:34:45Z
has_obo_namespace: mouse_pathology.ontology
id: MPATH:878

Axiom
annotated source: foreign body aspiration pneumonia
annotated property: definition
annotated target: Pneumonia caused by aspiration of a foreign body.
database_cross_reference: MPATH:Pathology Committee

gingivitis
type: Class
subclass of: inflammation
definition: Inflammation of the tooth gum
created by: Paul
creation date: 2012-09-03T05:37:29Z
has_obo_namespace: mouse_pathology.ontology
id: MPATH:879

Axiom
annotated source: gingivitis
annotated property: definition
annotated target: Inflammation of the tooth gum
database_cross_reference: MPATH:Pathology Committee

nephroblastomatosis
type: Class
definition: nephroblastomatosis
has_obo_namespace: mouse_pathology.ontology
id: MPATH:88
comment: Obsolete - subsumed into MPATH:82
deprecated: true

Axiom
annotated source: nephroblastomatosis
annotated property: definition
annotated target: nephroblastomatosis
database_cross_reference: Pathbase: Curation

foreign body gingivitis
type: Class
subclass of: gingivitis
definition: inflammation of the tooth gum caused by a foreign body.
created by: Paul
creation date: 2012-09-03T05:38:14Z
has_obo_namespace: mouse_pathology.ontology
id: MPATH:880
comment: Generally caused by hair or food debris

Axiom
annotated source: foreign body gingivitis
annotated property: definition
annotated target: inflammation of the tooth gum caused by a foreign body.
database_cross_reference: MAPTH:<new dbxref>
database_cross_reference: MPATH:Pathology Committee

reactive fibrosis
type: Class
subclass of: fibrosis
definition: Fibrotic reaction to presence of a foreign body.
created by: Paul
creation date: 2012-09-03T05:44:35Z
has_obo_namespace: mouse_pathology.ontology
id: MPATH:881

Axiom
annotated source: reactive fibrosis
annotated property: definition
annotated target: Fibrotic reaction to presence of a foreign body.
database_cross_reference: MPATH:Pathology Committee

hepatic peri-ductal inflammation
type: Class
subclass of: inflammation
definition: Inflammatory cell infiltrate around bile ducts within the liver.
created by: Paul
creation date: 2012-09-04T11:07:32Z
has_obo_namespace: mouse_pathology.ontology
id: MPATH:882

Axiom
annotated source: hepatic peri-ductal inflammation
annotated property: definition
annotated target: Inflammatory cell infiltrate around bile ducts within the liver.
database_cross_reference: MPATH:JPS

pneumonitis
type: Class
subclass of: inflammation
definition: An interstitial, granulomatous, fibrosing inflammation of the lung, especially of the bronchioles and alveoli.
created by: Paul
creation date: 2012-09-04T11:18:21Z
has_obo_namespace: mouse_pathology.ontology
id: MPATH:883

Axiom
annotated source: pneumonitis
annotated property: definition
annotated target: An interstitial, granulomatous, fibrosing inflammation of the lung, especially of the bronchioles and alveoli.
database_cross_reference: MPATH:JPS

histiocytic pneumonitis
type: Class
subclass of: pneumonitis
definition: Pneumonitis involving subpleural histiocytosis.
created by: Paul
creation date: 2012-09-04T11:19:22Z
has_obo_namespace: mouse_pathology.ontology
id: MPATH:884

Axiom
annotated source: histiocytic pneumonitis
annotated property: definition
annotated target: Pneumonitis involving subpleural histiocytosis.
database_cross_reference: MPATH:JPS

metastatic tumor
type: Class
subclass of: neoplasm
definition: metastatic tumour of unspecified origin
created by: Paul
creation date: 2012-09-04T11:28:57Z
has_obo_namespace: mouse_pathology.ontology
id: MPATH:885

Axiom
annotated source: metastatic tumor
annotated property: definition
annotated target: metastatic tumour of unspecified origin
database_cross_reference: MPATH:Pathology Committee

pulmonary metastasis
type: Class
subclass of: metastatic tumor
definition: Metastatic tumour of unspecified origin in the lung.
created by: Paul
creation date: 2012-09-04T11:30:02Z
has_obo_namespace: mouse_pathology.ontology
id: MPATH:886

Axiom
annotated source: pulmonary metastasis
annotated property: definition
annotated target: Metastatic tumour of unspecified origin in the lung.
database_cross_reference: MPATH:Pathology Committee

lymphatic metastasis
type: Class
subclass of: metastatic tumor
definition: Metastatic tumor in the lymphatic vessels or lymph nodes of unspecified origin.
created by: Paul
creation date: 2012-09-04T11:32:15Z
has_obo_namespace: mouse_pathology.ontology
id: MPATH:887

Axiom
annotated source: lymphatic metastasis
annotated property: definition
annotated target: Metastatic tumor in the lymphatic vessels or lymph nodes of unspecified origin.
database_cross_reference: MPATH:Pathology Committee

onychogryphosis
type: Class
subclass of: hypertrophic tissue
definition: Hypertrophy of the nail bed resulting in abnormally long, curved and thickened nails.
created by: Paul
creation date: 2012-09-04T12:10:49Z
has_obo_namespace: mouse_pathology.ontology
id: MPATH:888

Axiom
annotated source: onychogryphosis
annotated property: definition
annotated target: Hypertrophy of the nail bed resulting in abnormally long, curved and thickened nails.
database_cross_reference: MPATH:JPS

Hirano body
type: Class
subclass of: protein deposition
definition: intracellular aggregates of actin and actin-associated proteins first observed in neurons (nerve cells) by Asao Hirano. PMID: 21978358
created by: Paul
creation date: 2020-05-19T02:38:14Z
has_obo_namespace: mouse_pathology.ontology
id: MPATH:889

Axiom
annotated source: Hirano body
annotated property: definition
annotated target: intracellular aggregates of actin and actin-associated proteins first observed in neurons (nerve cells) by Asao Hirano. PMID: 21978358
database_cross_reference: MPATH:PNS

cardiovascular developmental defect
type: Class
subclass of: organ specific developmental defect
definition: Abnormal development of the heart or vascular tissue resulting in morphological abnormality.
has_obo_namespace: mouse_pathology.ontology
id: MPATH:89

Axiom
annotated source: cardiovascular developmental defect
annotated property: definition
annotated target: Abnormal development of the heart or vascular tissue resulting in morphological abnormality.
database_cross_reference: Pathbase: Curation

fibrinoid necrosis
type: Class
subclass of: necrosis
definition: Necrosis in which the necrotic tissue shows deeply eosinophilic staining similar to that of fibrin.
has_obo_namespace: mouse_pathology.ontology
id: MPATH:9
comment: Frequently occurs in the walls of blood vessels and in connective tissue in diseases such as disseminated Lupus erythrematosis and polyarteritis nodosa, scleroderma, dermatomyositis and rheumatic fever.

Axiom
annotated source: fibrinoid necrosis
annotated property: definition
annotated target: Necrosis in which the necrotic tissue shows deeply eosinophilic staining similar to that of fibrin.
database_cross_reference: ISBN:0781727286

aneurysm
type: Class
subclass of: developmental or adult structural defect
definition: Localised dilation of an artery or heart chamber usually due to an acquired or congenital weakness of the wall of the artery or chamber.
has_obo_namespace: mouse_pathology.ontology
id: MPATH:90

Axiom
annotated source: aneurysm
annotated property: definition
annotated target: Localised dilation of an artery or heart chamber usually due to an acquired or congenital weakness of the wall of the artery or chamber.
database_cross_reference: Pathbase: Pathology Committee

arteriovenous anastomosis
type: Class
subclass of: cardiovascular developmental defect
definition: Formation of vessels between arterioles and venules bypassing capillary circulation.
has_obo_namespace: mouse_pathology.ontology
has_related_synonym: Anastomosis arteriolovenularis
has_related_synonym: anastomosis arteriovenosa
has_related_synonym: arteriolovenular anastomosis
id: MPATH:91

Axiom
annotated source: arteriovenous anastomosis
annotated property: definition
annotated target: Formation of vessels between arterioles and venules bypassing capillary circulation.
database_cross_reference: Pathbase: Curation

Axiom
annotated source: arteriovenous anastomosis
annotated property: has_related_synonym
annotated target: Anastomosis arteriolovenularis
database_cross_reference: Pathbase: Curation

Axiom
annotated source: arteriovenous anastomosis
annotated property: has_related_synonym
annotated target: anastomosis arteriovenosa
database_cross_reference: Pathbase: Curation

Axiom
annotated source: arteriovenous anastomosis
annotated property: has_related_synonym
annotated target: arteriolovenular anastomosis
database_cross_reference: Pathbase: Curation

cardiac defect
type: Class
subclass of: cardiovascular developmental defect
definition: Structural, organisational or growth related defects in cardiac development.
has_obo_namespace: mouse_pathology.ontology
has_related_synonym: heart abnormalities
id: MPATH:92

Axiom
annotated source: cardiac defect
annotated property: definition
annotated target: Structural, organisational or growth related defects in cardiac development.
database_cross_reference: Pathbase: Curation

Axiom
annotated source: cardiac defect
annotated property: has_related_synonym
annotated target: heart abnormalities
database_cross_reference: Pathbase: Curation

cardiac septation defect
type: Class
subclass of: cardiac defect
definition: Abnormality in the wall between the atria or ventricles, or defects in the truncoconal septum, of the heart; usually incomplete closure.
has_obo_namespace: mouse_pathology.ontology
id: MPATH:93

Axiom
annotated source: cardiac septation defect
annotated property: definition
annotated target: Abnormality in the wall between the atria or ventricles, or defects in the truncoconal septum, of the heart; usually incomplete closure.
database_cross_reference: Pathbase: Curation

valve defect
type: Class
subclass of: cardiac defect
definition: Malformation of the membranous folds of the heart that prevent reflux of fluid.
has_obo_namespace: mouse_pathology.ontology
id: MPATH:94

Axiom
annotated source: valve defect
annotated property: definition
annotated target: Malformation of the membranous folds of the heart that prevent reflux of fluid.
database_cross_reference: Pathbase: Curation

hypertrophic ventricle
type: Class
subclass of: cardiac defect
definition: Thickening of the wall of one or both of the heart ventricles.
has_obo_namespace: mouse_pathology.ontology
id: MPATH:95

Axiom
annotated source: hypertrophic ventricle
annotated property: definition
annotated target: Thickening of the wall of one or both of the heart ventricles.
database_cross_reference: Pathbase: Pathology Committee

hypoplastic ventricle
type: Class
subclass of: cardiac defect
definition: Reduction in cell number of one or both of the two lower chambers of the heart.
has_obo_namespace: mouse_pathology.ontology
id: MPATH:96

Axiom
annotated source: hypoplastic ventricle
annotated property: definition
annotated target: Reduction in cell number of one or both of the two lower chambers of the heart.
database_cross_reference: Pathbase: Pathology Committee

dissecting aneurysm
type: Class
subclass of: aneurysm
definition: Follows the presence of a hematoma in the wall of an artery Splitting of the media occurs, blood enters the split through a tear in the intima.
has_obo_namespace: mouse_pathology.ontology
id: MPATH:97

Axiom
annotated source: dissecting aneurysm
annotated property: definition
annotated target: Follows the presence of a hematoma in the wall of an artery Splitting of the media occurs, blood enters the split through a tear in the intima.
database_cross_reference: ISBN:0781727286

lymphangiectasis
type: Class
subclass of: ectasia
subclass of: cardiovascular developmental defect
definition: A stretching and widening of the lymphatic vessels.
has_obo_namespace: mouse_pathology.ontology
has_related_synonym: Lymphectasia
has_related_synonym: telangiectasia lymphatica
id: MPATH:98

Axiom
annotated source: lymphangiectasis
annotated property: definition
annotated target: A stretching and widening of the lymphatic vessels.
database_cross_reference: Pathbase: Pathology Committee

Axiom
annotated source: lymphangiectasis
annotated property: has_related_synonym
annotated target: Lymphectasia
database_cross_reference: Pathbase: Curation

Axiom
annotated source: lymphangiectasis
annotated property: has_related_synonym
annotated target: telangiectasia lymphatica
database_cross_reference: Pathbase: Curation

varices
type: Class
subclass of: developmental or adult structural defect
definition: An enlarged and often tortuous vein.
has_obo_namespace: mouse_pathology.ontology
id: MPATH:99

Axiom
annotated source: varices
annotated property: definition
annotated target: An enlarged and often tortuous vein.
database_cross_reference: Pathbase: Pathology Committee