{
  "meta": {
    "file_name": "RosettaQ__RUN__EXP-0007-017__20260725T1546Z__nulo-espacial-contiguo--instrumento-de-medicion.json",
    "file_id": "EXP-0007-017",
    "type": "RUN",
    "is_demo": false,
    "scope_note": "Contribucion metodologica central del track. Aplicado a los 7 metodos sobre las 3 dianas con ground truth: ninguno alcanza significancia. El resultado va en contra de nuestra propia metrica y se publica igual.",
    "schema": "rosettaq-archive/v2",
    "sealed_at": "2026-07-26T12:57:00.567444+00:00",
    "sealed_by": {
      "lib": "rosettaq_seal.py",
      "lib_version": "2.0.0",
      "lib_sha256": "sha256:0965542a9532451b6ddea7f5b7bb1724dfd2499a84ecf72ace8031a0cb682008",
      "harness": "paired_null.py",
      "harness_version": "1.0.0",
      "harness_sha256": "sha256:6f53f3a617c6a6223aa080e645f2e9ecd88093c6e16bf572e94a1a1bbbfdc88f",
      "convention": "v2: sha256(json.dumps({meta sin content_hash/schema, cuerpo sin storage}, sort_keys=True, ensure_ascii=False))"
    },
    "content_hash": "sha256:ff29769b177ed8c5a7f5cb653e64308b350e304cc086e6eaaf147d62417a43df"
  },
  "w6": {
    "que": {
      "recipe_id": "RQ-0007",
      "recipe_name": "Nulo espacial de bolsillo contiguo — instrumento de medicion",
      "problem_class": "Metodologia estadistica para prediccion de sitios alostericos",
      "instance": "KRAS G12C, BCR-ABL1 y miosina cardiaca",
      "quantum_side": {
        "nota": "el instrumento se aplica a TODOS los metodos por igual, empezando por el nuestro"
      },
      "classical_side": {
        "nota": "idem"
      },
      "ground_truth": "los mismos sitios geometricos de EXP-0007-013/014/015",
      "outcome": "NADA es significativo, para ningun metodo, en ninguna diana: todos los p entre 0.15 y 0.85",
      "metric": "p-valor por permutacion contra bolsillos distales contiguos del mismo tamano",
      "hallazgo_central": "El percentil medio de un sitio alosterico no se puede comparar contra 50 suponiendo residuos independientes: los residuos verdaderos forman UN bolsillo contiguo, estan correlacionados espacialmente y el n efectivo es mucho menor que el numero de residuos. Toda prueba que suponga independencia infla la significancia. Al reemplazar ese supuesto por el nulo correcto, los z ingenuos de hasta |4.64| colapsan a |z| < 1.2.",
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      "prueba_pareada": {
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            ],
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            "pct_ctqw": 57.13,
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            "p_cuantico_peor": 0.307
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          {
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            "k_site": 20,
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            "pct_ctqw": 60.42,
            "pct_diffusion": 60.42,
            "delta_obs": 0.0,
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          },
          {
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            "pct_ctqw": 62.77,
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            "p_cuantico_mejor": 0.3558,
            "p_cuantico_peor": 0.6442
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          {
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            "pct_ctqw": 60.26,
            "pct_diffusion": 59.69,
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          },
          {
            "cutoff": 9.0,
            "window": [
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            "k_site": 20,
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          },
          {
            "cutoff": 9.5,
            "window": [
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            "k_site": 20,
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            "pct_diffusion": 58.38,
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            "p_cuantico_mejor": 0.5638,
            "p_cuantico_peor": 0.4362
          },
          {
            "cutoff": 9.5,
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            "k_site": 20,
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            "pct_ctqw": 50.32,
            "pct_diffusion": 58.32,
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          },
          {
            "cutoff": 9.5,
            "window": [
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            "k_site": 20,
            "n_distal": 391,
            "pct_ctqw": 54.74,
            "pct_diffusion": 57.05,
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            "p_cuantico_peor": 0.5224
          },
          {
            "cutoff": 10.0,
            "window": [
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            "k_site": 20,
            "n_distal": 391,
            "pct_ctqw": 58.85,
            "pct_diffusion": 58.17,
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            "p_cuantico_mejor": 0.4568,
            "p_cuantico_peor": 0.5432
          },
          {
            "cutoff": 10.0,
            "window": [
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            "k_site": 20,
            "n_distal": 391,
            "pct_ctqw": 57.63,
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            "p_cuantico_mejor": 0.4546,
            "p_cuantico_peor": 0.5454
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          {
            "cutoff": 10.0,
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            "k_site": 20,
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            "pct_diffusion": 55.96,
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            "p_cuantico_mejor": 0.4506,
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        ],
        "CARDIAC_MYOSIN": [
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              4.0
            ],
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            "n_distal": 935,
            "pct_ctqw": 60.28,
            "pct_diffusion": 58.49,
            "delta_obs": 1.78,
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            "z": 0.25,
            "p_cuantico_mejor": 0.391,
            "p_cuantico_peor": 0.609
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          {
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          },
          {
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            "pct_diffusion": 57.68,
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            "p_cuantico_peor": 0.7882
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          {
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            "pct_diffusion": 57.37,
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          {
            "cutoff": 9.5,
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              8.0
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            "pct_diffusion": 58.09,
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            "p_cuantico_mejor": 0.4042,
            "p_cuantico_peor": 0.5958
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          {
            "cutoff": 9.5,
            "window": [
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          {
            "cutoff": 10.0,
            "window": [
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            "n_distal": 935,
            "pct_ctqw": 67.98,
            "pct_diffusion": 57.13,
            "delta_obs": 10.85,
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            "null_sd": 10.84,
            "z": 0.98,
            "p_cuantico_mejor": 0.1678,
            "p_cuantico_peor": 0.8322
          },
          {
            "cutoff": 10.0,
            "window": [
              0.5,
              8.0
            ],
            "k_site": 15,
            "n_distal": 935,
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            "pct_diffusion": 57.75,
            "delta_obs": 8.94,
            "null_media": 0.35,
            "null_sd": 10.39,
            "z": 0.83,
            "p_cuantico_mejor": 0.1772,
            "p_cuantico_peor": 0.8228
          },
          {
            "cutoff": 10.0,
            "window": [
              0.5,
              14.0
            ],
            "k_site": 15,
            "n_distal": 935,
            "pct_ctqw": 67.2,
            "pct_diffusion": 58.49,
            "delta_obs": 8.71,
            "null_media": 0.51,
            "null_sd": 9.06,
            "z": 0.91,
            "p_cuantico_mejor": 0.1818,
            "p_cuantico_peor": 0.8182
          }
        ]
      },
      "potencia": {
        "nota": "el tamano de efecto de miosina (d=+0.589) implica cuantas dianas harian falta para zanjar el unico indicio favorable al cuantico",
        "dianas_para_p_005": 8,
        "dianas_para_p_001": 16,
        "combinado_tres_dianas_d": -0.196,
        "combinado_stouffer_z": -0.34,
        "lectura": "no hay evidencia en ninguna direccion con tres dianas; el conjunto de validacion del propio reto es demasiado chico para detectar el efecto que parece existir"
      }
    },
    "como": {
      "protocol": "nulo por permutacion espacial: se sortea un residuo distal semilla y se toman sus k-1 vecinos distales mas cercanos (k = tamano del sitio verdadero). Preserva contiguidad, tamano y la restriccion distal. La prueba pareada evalua la DIFERENCIA cuantico-menos-clasico contra el mismo nulo, que tiene mucha menos varianza porque ambos propagadores comparten grafo, fuente y ventana.",
      "instance_params": {
        "nulo_espacial": {
          "nperm": 2000,
          "seed": 20260717,
          "cutoff_A": 8.5,
          "window": [
            0.5,
            8.0
          ]
        },
        "prueba_pareada": {
          "nperm": 5000,
          "seed": 20260717,
          "configuraciones_por_diana": 18
        }
      },
      "sweep_note": "la prueba pareada corre sobre la rejilla completa congelada, no sobre una configuracion elegida; se reporta cada celda",
      "lib_versions": {
        "prody": "2.6.1",
        "numpy": "2.4.4",
        "scipy": "1.16.3",
        "python": "3.11.15"
      },
      "compute": "contenedor cloud Cowork (CPU, Linux)",
      "harness": "paired_null.py",
      "raw_data_url": "https://raw.githubusercontent.com/RosettaQuantum/evidence/main/data/2026/07/spatial_null.json ; https://raw.githubusercontent.com/RosettaQuantum/evidence/main/data/2026/07/paired_null.json",
      "procedencia": [
        {
          "archivo": "spatial_null.json",
          "sha256": "sha256:3914def63a518be2b012b4ec290a8f375865f78860539c7ff19bd91b61c08f61"
        },
        {
          "archivo": "paired_null.json",
          "sha256": "sha256:43015a13119fdee4a9e4399bfc35f97f6ace9ae6fe76d55d6b34877c479664b3"
        }
      ],
      "scripts": [
        {
          "archivo": "spatial_null.py",
          "sha256": "sha256:61194e2eb956df3741f6ad0b5b5b5c1f0534f0e4a42cbcca4a03e22d16d173c5"
        },
        {
          "archivo": "paired_null.py",
          "sha256": "sha256:6f53f3a617c6a6223aa080e645f2e9ecd88093c6e16bf572e94a1a1bbbfdc88f"
        },
        {
          "archivo": "power.py",
          "sha256": "sha256:06dd8df00affb4d47fa6f58baf94ff587de8c25ddaf8bc8ad845ada33d09ca81"
        }
      ]
    },
    "donde": {
      "quantum_backend": "CTQW por eigendescomposicion",
      "classical_backend": "difusion, GNM, ANM, betweenness, closeness, nulo aleatorio",
      "protein_source": "RCSB PDB via ProDy",
      "region": "cloud sandbox Anthropic"
    },
    "porque": {
      "hypothesis": "la significancia reportada en este campo esta inflada por un supuesto de independencia que los sitios alostericos violan por construccion",
      "question": "Con el nulo espacial correcto, algun metodo separa el bolsillo verdadero del azar?",
      "ledger_goal": "entregar el INSTRUMENTO DE MEDICION, no otra metrica: un nulo reutilizable con el que evaluar la metrica de cualquiera, aplicado primero a la nuestra y con el resultado en contra"
    },
    "cuando": {
      "started_at": "2026-07-25T15:46:34.786148+00:00",
      "archived_at": "2026-07-25T15:46:34.786148+00:00",
      "timezone_note": "UTC; equipo en America/Punta_Arenas"
    },
    "quien": {
      "operator": "Nicholas",
      "agents": [
        "Claude (Cowork cloud)",
        "paired_null.py"
      ],
      "judge_protocol_version": "juez-v1",
      "org": "Rosetta Quantum",
      "team": "Rosetta Quantum"
    }
  },
  "storage": {
    "policy": "triple-copia identica; verificar con content_hash",
    "locations": [
      {
        "n": 1,
        "kind": "github",
        "role": "primary",
        "url": "https://github.com/RosettaQuantum/evidence/blob/main/runs/2026/07/RosettaQ__RUN__EXP-0007-017__20260725T1546Z__nulo-espacial-contiguo--instrumento-de-medicion.json",
        "raw_url": "https://raw.githubusercontent.com/RosettaQuantum/evidence/main/runs/2026/07/RosettaQ__RUN__EXP-0007-017__20260725T1546Z__nulo-espacial-contiguo--instrumento-de-medicion.json"
      },
      {
        "n": 2,
        "kind": "codeberg",
        "role": "mirror",
        "url": "https://codeberg.org/RosettaQuantum/evidence/src/branch/main/runs/2026/07/RosettaQ__RUN__EXP-0007-017__20260725T1546Z__nulo-espacial-contiguo--instrumento-de-medicion.json"
      },
      {
        "n": 3,
        "kind": "cloudflare-d1",
        "role": "mirror",
        "uri": "d1://rosettaq-ledger/run_archives/EXP-0007-017"
      }
    ]
  }
}