This PsN version has been tested on the following systems: Windows 10 64-bit with Strawberry Perl 5.22.3 , gfortran 4.9.2 and NONMEM 7.4.3 Windows 7 64-bit with Strawberry Perl 5.22.3, gfortran 4.9.2 and NONMEM 7.4.3 Ubuntu Linux 18.10 with Perl 5.26.2, gfortran 8.3.0 and NONMEM 7.4.3 CentOS 7 with Perl 5.16.3, gfortran 5.1.0 and NONMEM 7.4.3 ************************ Installation ************************ Follow the installation instructions on https://uupharmacometrics.github.io/PsN/install.html ************************ Documentation ************************ All documentation is found in the doc subdirectory of the PsN installation directory. During installation it is also possible to have all documentation copied to a user-specified directory. All documentation can also be downloaded from the PsN website https://uupharmacometrics.github.io/PsN/docs.html ************************ Dependencies ************************ - The rplots functionality now depends on the R package PsNR available from github at UUPharmacometrics/PsNR ************************ Known issues ************************ - Windows users need to be careful to choose a Perl version where the extra modules needed for PsN are available. For new Perl installations the PsN team recommends Strawberry Perl See the instructions on https://uupharmacometrics.github.io/PsN/install.html - Installation problem on some Windows systems where perl 'system' command does not work. Make sure perl module File::Copy::Recursive is installed *before* (re)running the installation script setup.pl ********************************************* Changes and bug fixes from PsN 4.8.0 to 4.9.0 ********************************************* ___General___ - Dots in datasets will always be seen by PsN as zero, which is the same way NM-TRAN handles dots. This will change the behaviour of transitions in randtest. - Empty items between commas in data set will be interpreted as zero (this is default NM-TRAN interpretation) - Code for rplots is behing moved to the new R-package PsNR ___common_options___ - New clean level 5 to remove entire rundirectory - New option -debug_rmd to retain the tex file after rendering rmarkdown with -rplots ___crossval___ - Add -stratify_on option ___sumo___ - New option -parameters to only show parameter estimates - Fix bug causing RSEs not to be shown if no THETAs were estimated - Fix bug causing a display of ERROR when the covariance step was OMITTED ___mcmp___ - Fix bug causing columns with names ending with DATE to become removed ___bootstrap___ - Phi files from $ETAS will be used for dOFV calculation runs ___vpc/npc___ - Fix bug causing simulation tables after a tte run being copied to the wrong directory when using the -model_subdir option - Fix bug causing lst-file for original model to not be copied to the m1 directory (but instead into the root of the run directory) - Fix bug causing NOPREDICTION to be removed from an original $SIMULATION ___frem___ - Give useful error message if a covariate has zero variance at baseline. - Add OFV for M1-M4 in frem_results ___proseval___ - Added a NUMOBS counter that can be used in the model code ___scm___ - linearized scm will now initialize etas with phi file of base model for each iteration. - The ext file of the final model is also copied to final_models directory to retain the full precision of estimates ___linearize___ - Many bugfixes ___sse___ - New option -special_table to let the user handle the table generation in the simulation model ___simeval___ - New option -separate to be able to use simeval for models with NOPREDICTION ___sir___ - Force input cov matrix to be positive definite after giving a warning. - Force matrix used for sampling to be positive definite. - Phi files from $ETAS will be used for dOFV calculation runs ___cdd___ - New option 'ignore' that would let cdd use IGNORE statements instead of generating new datasets. This will save alot of disk space. ___rplots___ - Most rplots code moved into the separate PsNR package. ___transform___ - New transform derivatives