********************************************* Changes and bug fixes from PsN 4.9.0 to 5.0.0 ********************************************* ___General___ - The PsN documentation no longer comes bundled with the PsN installation package ___common_options___ - New option -slurm_cluster to select a cluster when more than one is available - New option -html that will render rmarkdown to html instead of pdf - Remove unused common option -debug ___Cluster/Grid___ - All NONMEM jobs will automatically be cancelled when the PsN process is interrupted ___runrecord___ - Support zero-padded run numbers, like run001.mod ___sumo___ - New option -covariance to present off-diagonal omegas and sigmas as covariances - Removed -debug option. Didn't do anything ___vpc/npc___ - Constrain default automatic binning to have between 2 and 10 bins ___frem___ - Automatic reordering of OMEGAs and ETAs when needed. - Remove -fork_runs option - Postfrem replaced with postprocessing in Pharmpy - New method for parameter uncertainty: BIPP ___scm___ - Support for covariates not in the dataset, but derived in the model code - Fallback to regular mean and median calculations if the new weighted mean/median of a time-varying covariate is outside of the original range of the covariate. ___sse___ - New option -initial_etas to use etas from simulation models ___transform___ - Fix bug causing full block initial estimates to be off and sometimes non-positive-definite. ___qa___ - Extensive updates