addicto.owl
type: Ontology
version IRI: http://addictovocab.org/addicto.owl/2025-09-24
comment: The Addiction Ontology (AddictO) is an ontology being developed all aspects of addiction research.

BFO OWL specification label
type: AnnotationProperty
editor preferred label: BFO OWL specification label
definition: Relates an entity in the ontology to the name of the variable that is used to represent it in the code that generates the BFO OWL file from the lispy specification.
curator note: Really of interest to developers only

BFO CLIF specification label
type: AnnotationProperty
editor preferred label: BFO CLIF specification label
definition: Relates an entity in the ontology to the term that is used to represent it in the the CLIF specification of BFO2
definition source: Person:Alan Ruttenberg
curator note: Really of interest to developers only

editor preferred label
type: AnnotationProperty
editor preferred label: editor preferred label
editor preferred label: editor preferred term
editor preferred label: editor preferred term~editor preferred label
has curation status: IAO_0000122
definition: The concise, meaningful, and human-friendly name for a class or property preferred by the ontology developers. (US-English)
definition editor: PERSON:Daniel Schober
definition source: GROUP:OBI:<http://purl.obolibrary.org/obo/obi>
label: editor preferred term
label: editor preferred term~editor preferred label

example of usage
type: AnnotationProperty
editor preferred label: example
editor preferred label: example of usage
has curation status: IAO_0000122
definition: A phrase describing how a class name should be used. May also include other kinds of examples that facilitate immediate understanding of a class semantics, such as widely known prototypical subclasses or instances of the class. Although essential for high level terms, examples for low level terms (e.g., Affymetrix HU133 array) are not
definition: A phrase describing how a term should be used and/or a citation to a work which uses it. May also include other kinds of examples that facilitate immediate understanding, such as widely know prototypes or instances of a class, or cases where a relation is said to hold.
definition editor: PERSON:Daniel Schober
definition source: GROUP:OBI:<http://purl.obolibrary.org/obo/obi>
database_cross_reference: IAO:0000112
has_obo_namespace: uberon
id: example_of_usage
is metadata tag: true
shorthand: example_of_usage

has curation status
type: AnnotationProperty
editor preferred label: has curation status
definition editor: PERSON:Alan Ruttenberg
definition editor: PERSON:Bill Bug
definition editor: PERSON:Melanie Courtot
definition source: OBI_0000281

definition
type: AnnotationProperty
editor preferred label: definition
editor preferred label: textual definition
has curation status: IAO_0000122
definition: English language definitions of what NCI means by the concept. These are limited to 1024 characters. They may also include information about the definition's source and attribution in a form that can easily be interpreted by software.
definition: The official OBI definition, explaining the meaning of a class or property. Shall be Aristotelian, formalized and normalized. Can be augmented with colloquial definitions.
definition: The official definition, explaining the meaning of a class or property. Shall be Aristotelian, formalized and normalized. Can be augmented with colloquial definitions.
definition: The official definition.
editor note: 2012-04-05: Barry Smith The official OBI definition, explaining the meaning of a class or property: 'Shall be Aristotelian, formalized and normalized. Can be augmented with colloquial definitions' is terrible. Can you fix to something like: A statement of necessary and sufficient conditions explaining the meaning of an expression referring to a class or property. Alan Ruttenberg Your proposed definition is a reasonable candidate, except that it is very common that necessary and sufficient conditions are not given. Mostly they are necessary, occasionally they are necessary and sufficient or just sufficient. Often they use terms that are not themselves defined and so they effectively can't be evaluated by those criteria. On the specifics of the proposed definition: We don't have definitions of 'meaning' or 'expression' or 'property'. For 'reference' in the intended sense I think we use the term 'denotation'. For 'expression', I think we you mean symbol, or identifier. For 'meaning' it differs for class and property. For class we want documentation that let's the intended reader determine whether an entity is instance of the class, or not. For property we want documentation that let's the intended reader determine, given a pair of potential relata, whether the assertion that the relation holds is true. The 'intended reader' part suggests that we also specify who, we expect, would be able to understand the definition, and also generalizes over human and computer reader to include textual and logical definition. Personally, I am more comfortable weakening definition to documentation, with instructions as to what is desirable. We also have the outstanding issue of how to aim different definitions to different audiences. A clinical audience reading chebi wants a different sort of definition documentation/definition from a chemistry trained audience, and similarly there is a need for a definition that is adequate for an ontologist to work with.
definition editor: PERSON:Daniel Schober
definition source: GROUP:OBI:<http://purl.obolibrary.org/obo/obi>
has exact synonym: DEFINITION
label: textual definition

Axiom
annotated source: definition
annotated property: definition
annotated target: The official definition, explaining the meaning of a class or property. Shall be Aristotelian, formalized and normalized. Can be augmented with colloquial definitions.
database_cross_reference: url:http://purl.obolibrary.org/obo/iao.owl

Axiom
annotated source: definition
annotated property: definition
annotated target: The official definition.
database_cross_reference: url:http://purl.obolibrary.org/obo/iao.owl

editor note
type: AnnotationProperty
editor preferred label: editor note
has curation status: IAO_0000122
definition: An administrative note intended for its editor. It may not be included in the publication version of the ontology, so it should contain nothing necessary for end users to understand the ontology.
definition editor: PERSON:Daniel Schober
definition source: GROUP:OBI:<http://purl.obfoundry.org/obo/obi>
definition source: GROUP:OBI:<http://purl.obofoundry.org/obo/obi>
database_cross_reference: IAO:0000116
has_obo_namespace: uberon
id: editor_note
is metadata tag: true
is metadata tag: 1
shorthand: editor_note

definition editor
type: AnnotationProperty
editor preferred label: definition editor
editor preferred label: term editor
has curation status: IAO_0000122
definition: Name of editor entering the definition in the file. The definition editor is a point of contact for information regarding the term. The definition editor may be, but is not always, the author of the definition, which may have been worked upon by several people
definition: Name of editor entering the term in the file. The term editor is a point of contact for information regarding the term. The term editor may be, but is not always, the author of the definition, which may have been worked upon by several people
editor note: 20110707, MC: label update to term editor and definition modified accordingly. See http://code.google.com/p/information-artifact-ontology/issues/detail?id=115.
editor note: 20110707, MC: label update to term editor and definition modified accordingly. See https://github.com/information-artifact-ontology/IAO/issues/115.
definition editor: PERSON:Daniel Schober
definition source: GROUP:OBI:<http://purl.obolibrary.org/obo/obi>
label: term editor

alternative term
type: AnnotationProperty
editor preferred label: alternative label
editor preferred label: alternative term
has curation status: IAO_0000125
definition: A label for a class or property that can be used to refer to the class or property instead of the preferred rdfs:label. Alternative labels should be used to indicate community- or context-specific labels, abbreviations, shorthand forms and the like.
definition: An alternative name for a class or property which means the same thing as the preferred name (semantically equivalent)
definition editor: OBO Operations committee
definition editor: PERSON:Daniel Schober
definition source: GROUP:OBI:<http://purl.obolibrary.org/obo/obi>
comment: Consider re-defing to: An alternative name for a class or property which can mean the same thing as the preferred name (semantically equivalent, narrow, broad or related).
label: alternative label

definition source
type: AnnotationProperty
editor preferred label: definition source
has curation status: IAO_0000122
definition: Formal citation, e.g. identifier in external database to indicate / attribute source(s) for the definition. Free text indicate / attribute source(s) for the definition. EXAMPLE: Author Name, URI, MeSH Term C04, PUBMED ID, Wiki uri on 31.01.2007
definition: formal citation, e.g. identifier in external database to indicate / attribute source(s) for the definition. Free text indicate / attribute source(s) for the definition. EXAMPLE: Author Name, URI, MeSH Term C04, PUBMED ID, Wiki uri on 31.01.2007
definition editor: PERSON:Daniel Schober
definition source: Discussion on obo-discuss mailing-list, see http://bit.ly/hgm99w
definition source: GROUP:OBI:<http://purl.obolibrary.org/obo/obi>

curator note
type: AnnotationProperty
editor preferred label: curator note
has curation status: IAO_0000122
definition: An administrative note of use for a curator but of no use for a user
definition editor: PERSON:Alan Ruttenberg
database_cross_reference: IAO:0000232
has_obo_namespace: uberon
id: curator_notes
is metadata tag: true
is metadata tag: 1
shorthand: curator_notes
label: curator notes

term tracker item
type: AnnotationProperty
editor preferred label: term tracker item
example of usage: the URI for an OBI Terms ticket at sourceforge, such as https://sourceforge.net/p/obi/obi-terms/772/
has curation status: IAO_0000125
definition: An IRI or similar locator for a request or discussion of an ontology term.
definition editor: Person: Jie Zheng, Chris Stoeckert, Alan Ruttenberg
definition source: Person: Jie Zheng, Chris Stoeckert, Alan Ruttenberg
database_cross_reference: IAO:0000233
has_obo_namespace: external
has_obo_namespace: uberon
id: term_tracker_item
is class level: true
is metadata tag: true
shorthand: term_tracker_item
comment: The 'tracker item' can associate a tracker with a specific ontology term.

imported from
type: AnnotationProperty
editor preferred label: imported from
has curation status: IAO_0000125
definition: For external terms/classes, the ontology from which the term was imported
definition editor: PERSON:Alan Ruttenberg
definition editor: PERSON:Melanie Courtot
definition source: GROUP:OBI:<http://purl.obolibrary.org/obo/obi>

OBO foundry unique label
type: AnnotationProperty
editor preferred label: OBO foundry unique label
has curation status: IAO_0000125
definition: An alternative name for a class or property which is unique across the OBO Foundry.
editor note: The intended usage of that property is as follow: OBO foundry unique labels are automatically generated based on regular expressions provided by each ontology, so that SO could specify unique label = 'sequence ' + [label], etc. , MA could specify 'mouse + [label]' etc. Upon importing terms, ontology developers can choose to use the 'OBO foundry unique label' for an imported term or not. The same applies to tools .
definition editor: PERSON:Alan Ruttenberg
definition editor: PERSON:Bjoern Peters
definition editor: PERSON:Chris Mungall
definition editor: PERSON:Melanie Courtot
definition source: GROUP:OBO Foundry <http://obofoundry.org/>

elucidation
type: AnnotationProperty
editor preferred label: elucidation
definition editor: person:Alan Ruttenberg
definition source: Person:Barry Smith
elucidation: Primitive terms in a highest-level ontology such as BFO are terms which are so basic to our understanding of reality that there is no way of defining them in a non-circular fashion. For these, therefore, we can provide only elucidations, supplemented by examples and by axioms

has associated axiom(nl)
type: AnnotationProperty
editor preferred label: has associated axiom(nl)
definition editor: Person:Alan Ruttenberg
definition source: Person:Alan Ruttenberg
elucidation: An axiom associated with a term expressed using natural language

has associated axiom(fol)
type: AnnotationProperty
editor preferred label: has associated axiom(fol)
definition editor: Person:Alan Ruttenberg
definition source: Person:Alan Ruttenberg
elucidation: An axiom expressed in first order logic using CLIF syntax

synonym
type: AnnotationProperty

tag display synonym
type: AnnotationProperty

ISA alternative term
type: AnnotationProperty
editor preferred label: ISA alternative term
has curation status: IAO_0000122
definition: An alternative term used by the ISA tools project (http://isa-tools.org).
editor note: Requested by Alejandra Gonzalez-Beltran https://sourceforge.net/tracker/?func=detail&aid=3603413&group_id=177891&atid=886178
definition editor: Person: Alejandra Gonzalez-Beltran
definition editor: Person: Philippe Rocca-Serra
definition source: ISA tools project (http://isa-tools.org)

IEDB alternative term
type: AnnotationProperty
definition: An alternative term used by the IEDB.

Axiom
annotated source: IEDB alternative term
annotated property: definition
annotated target: An alternative term used by the IEDB.
database_cross_reference: url:https://www.iedb.org

never in taxon
type: AnnotationProperty
example of usage: tooth SubClassOf 'never in taxon' value 'Aves'
definition: x never in taxon T if and only if T is a class, and x does not instantiate the class expression "in taxon some T". Note that this is a shortcut relation, and should be used as a hasValue restriction in OWL.
OMO_0002000: PREFIX rdfs: <http://www.w3.org/2000/01/rdf-schema#> PREFIX owl: <http://www.w3.org/2002/07/owl#> PREFIX in_taxon: <http://purl.obolibrary.org/obo/RO_0002162> PREFIX never_in_taxon: <http://purl.obolibrary.org/obo/RO_0002161> CONSTRUCT { in_taxon: a owl:ObjectProperty . ?x owl:disjointWith [ a owl:Restriction ; owl:onProperty in_taxon: ; owl:someValuesFrom ?taxon ] . ?x rdfs:subClassOf [ a owl:Restriction ; owl:onProperty in_taxon: ; owl:someValuesFrom [ a owl:Class ; owl:complementOf ?taxon ] ] . } WHERE { ?x never_in_taxon: ?taxon . }
database_cross_reference: RO:0002161
id: never_in_taxon
is class level: true
is metadata tag: true
shorthand: never_in_taxon

present in taxon
type: AnnotationProperty
definition: S present_in_taxon T if some instance of T has some S. This does not means that all instances of T have an S - it may only be certain life stages or sexes that have S
OMO_0002000: PREFIX rdfs: <http://www.w3.org/2000/01/rdf-schema#> PREFIX owl: <http://www.w3.org/2002/07/owl#> PREFIX in_taxon: <http://purl.obolibrary.org/obo/RO_0002162> PREFIX present_in_taxon: <http://purl.obolibrary.org/obo/RO_0002175> CONSTRUCT { in_taxon: a owl:ObjectProperty . ?witness rdfs:label ?label . ?witness rdfs:subClassOf ?x . ?witness rdfs:subClassOf [ a owl:Restriction ; owl:onProperty in_taxon: ; owl:someValuesFrom ?taxon ] . } WHERE { ?x present_in_taxon: ?taxon . BIND(IRI(CONCAT( "http://purl.obolibrary.org/obo/RO_0002175#", MD5(STR(?x)), "-", MD5(STR(?taxon)) )) as ?witness) BIND(CONCAT(STR(?x), " in taxon ", STR(?taxon)) AS ?label) }
database_cross_reference: RO:0002175
id: present_in_taxon
is class level: true
is metadata tag: true
shorthand: present_in_taxon
comment: The SPARQL expansion for this relation introduces new named classes into the ontology. For this reason it is likely that the expansion should only be performed during a QC pipeline; the expanded output should usually not be included in a published version of the ontology.

SEPIO_editor_note
type: AnnotationProperty
comment: Used to capture development notes and design decisions or questions. All annotations using this property should be removed before publishing / releasing the ontology to the public (but ideally retained in some place as valuable documentation).

external_definition
type: AnnotationProperty
definition: An alternate textual definition for a class taken unmodified from an external source. This definition may have been used to derive a generalized definition for the new class.
database_cross_reference: UBPROP:0000001
id: external_definition
is metadata tag: true
shorthand: external_definition
comment: This annotation property may be replaced with an annotation property from an external ontology such as IAO

Axiom
annotated source: external_definition
annotated property: definition
annotated target: An alternate textual definition for a class taken unmodified from an external source. This definition may have been used to derive a generalized definition for the new class.
database_cross_reference: https://orcid.org/0000-0002-6601-2165

homology_notes
type: AnnotationProperty
definition: Notes on the homology status of this class.
database_cross_reference: UBPROP:0000003
id: homology_notes
is metadata tag: true
shorthand: homology_notes
comment: This annotation property may be replaced with an annotation property from an external ontology such as IAO

Axiom
annotated source: homology_notes
annotated property: definition
annotated target: Notes on the homology status of this class.
database_cross_reference: https://orcid.org/0000-0002-6601-2165

has_relational_adjective
type: AnnotationProperty
curator note: Used to connect a class to an adjectival form of its label. For example, a class with label 'intestine' may have a relational adjective 'intestinal'.
database_cross_reference: UBPROP:0000007
id: has_relational_adjective
is metadata tag: true
shorthand: has_relational_adjective

external_ontology_notes
type: AnnotationProperty
definition: Notes on how similar or equivalent classes are represented in other ontologies.
editor note: This annotation property may be replaced with an annotation property from an external ontology such as IAO
database_cross_reference: UBPROP:0000012
id: external_ontology_notes
is metadata tag: true
shorthand: external_ontology_notes

Axiom
annotated source: external_ontology_notes
annotated property: definition
annotated target: Notes on how similar or equivalent classes are represented in other ontologies.
database_cross_reference: https://orcid.org/0000-0002-6601-2165

contributor
type: AnnotationProperty
id: dc-contributor
is metadata tag: true
shorthand: dc-contributor

UNEP ignore
type: AnnotationProperty

created by
type: AnnotationProperty
definition: Author of the class.
label: created_by

Axiom
annotated source: created by
annotated property: definition
annotated target: Author of the class.
database_cross_reference: url:http://www.geneontology.org/formats/oboInOwl#created_by

creation date
type: AnnotationProperty
definition: Date class was created.
label: creation_date

Axiom
annotated source: creation date
annotated property: definition
annotated target: Date class was created.
database_cross_reference: url:http://www.geneontology.org/formats/oboInOwl#creation_date

has_alternative_id
type: AnnotationProperty
definition: ID of merged class.

Axiom
annotated source: has_alternative_id
annotated property: definition
annotated target: ID of merged class.
database_cross_reference: url:http://www.geneontology.org/formats/oboInOwl#hasAlternativeId

has_broad_synonym
type: AnnotationProperty
definition: An alternative label for a class or property which has a more general meaning than the preferred name/primary label.
term tracker item: https://github.com/information-artifact-ontology/ontology-metadata/issues/18
label: has broad synonym

database_cross_reference
type: AnnotationProperty
example of usage: disease characteristic (MONDO:0021125) has cross-reference (http://www.geneontology.org/formats/oboInOwl#hasDbXref) "NCIT:C41009"^^xsd:string
definition: An annotation property that links an ontology entity or a statement to a prefixed identifier or URI.
term tracker item: https://github.com/information-artifact-ontology/ontology-metadata/issues/123
contributor: https://orcid.org/0000-0002-7356-1779
label: has cross-reference

has exact synonym
type: AnnotationProperty
definition: An alternative label for a class or property which has the exact same meaning than the preferred name/primary label.
definition: Exact synonym.
definition: Fully qualified synonym, contains the string, term type, source, and an optional source code if appropriate. Each subfield is deliniated to facilitate interpretation by software.
definition: Synonym of the term.
definition editor: http://orcid.org/0000-0001-5208-3432
term tracker item: https://github.com/information-artifact-ontology/ontology-metadata/issues/20
has exact synonym: FULL_SYN
has exact synonym: Synonym with Source Data
label: has_exact_synonym

Axiom
annotated source: has exact synonym
annotated property: definition
annotated target: Exact synonym.
database_cross_reference: url:http://www.geneontology.org/formats/oboInOwl#hasExactSynonym

Axiom
annotated source: has exact synonym
annotated property: definition
annotated target: Synonym of the term.
comment: url:http://www.geneontology.org/formats/oboInOwl#hasExactSynonym

has_narrow_synonym
type: AnnotationProperty
definition: An alternative label for a class or property which has a more specific meaning than the preferred name/primary label.
definition editor: http://orcid.org/0000-0001-5208-3432
term tracker item: https://github.com/information-artifact-ontology/ontology-metadata/issues/19
label: has narrow synonym

has_obo_namespace
type: AnnotationProperty
definition: Name space of the ontology.
comment: disease_ontology

Axiom
annotated source: has_obo_namespace
annotated property: definition
annotated target: Name space of the ontology.
database_cross_reference: url:http://www.geneontology.org/formats/oboInOwl#hasOBONamespace

has_related_synonym
type: AnnotationProperty
definition: An alternative label for a class or property that has been used synonymously with the primary term name, but the usage is not strictly correct.
definition: Has related synonym.
term tracker item: https://github.com/information-artifact-ontology/ontology-metadata/issues/21
label: has related synonym

Axiom
annotated source: has_related_synonym
annotated property: definition
annotated target: Has related synonym.
database_cross_reference: url:http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym

id
type: AnnotationProperty
definition: An identifier for an individual entity.
definition: An identifier is an information content entity that is the outcome of a dubbing process and is used to refer to one instance of entity shared by a group of people to refer to that individual entity.

Axiom
annotated source: id
annotated property: definition
annotated target: An identifier for an individual entity.
database_cross_reference: url:http://purl.obolibrary.org/obo/IAO_0020000

Axiom
annotated source: id
annotated property: definition
annotated target: An identifier is an information content entity that is the outcome of a dubbing process and is used to refer to one instance of entity shared by a group of people to refer to that individual entity.
database_cross_reference: url:http://purl.obolibrary.org/obo/IAO_0020000

in_subset
type: AnnotationProperty
definition: In subset.

Axiom
annotated source: in_subset
annotated property: definition
annotated target: In subset.
database_cross_reference: url:http://www.geneontology.org/formats/oboInOwl#inSubset

shorthand
type: AnnotationProperty

comment
definition: Comment.

Axiom
annotated source: comment
annotated property: definition
annotated target: Comment.
database_cross_reference: url:http://www.w3.org/2000/01/rdf-schema#comment

isDefinedBy
OBO foundry unique label: is defined by

Axiom
annotated source: isDefinedBy
annotated property: OBO foundry unique label
annotated target: is defined by
comment: This is an experimental annotation

label
editor preferred label: label
definition: A human readable name for this class.
comment: A human-readable name for the subject.

Axiom
annotated source: label
annotated property: definition
annotated target: A human readable name for this class.
database_cross_reference: url:http://www.w3.org/2000/01/rdf-schema#label
database_cross_reference: url:https://www.w3.org/TR/owl-guide/

Axiom
annotated source: label
annotated property: definition
annotated target: A human readable name for this class.
database_cross_reference: url:http://www.w3.org/2000/01/rdf-schema#label

see also
has_obo_namespace: spatial
has_obo_namespace: uberon
id: seeAlso
is metadata tag: true
shorthand: seeAlso

has close match
type: AnnotationProperty
definition: A skos concept mapping used to link two concepts that are sufficiently similar that they can be used interchangeably.

Axiom
annotated source: has close match
annotated property: definition
annotated target: A skos concept mapping used to link two concepts that are sufficiently similar that they can be used interchangeably.
database_cross_reference: url:https://www.w3.org/2009/08/skos-reference/skos.html#closeMatch

has exact match
type: AnnotationProperty
definition: A skos concept mapping used to link two concepts, indicating a high degree of confidence that the concepts can be used interchangeably.

Axiom
annotated source: has exact match
annotated property: definition
annotated target: A skos concept mapping used to link two concepts, indicating a high degree of confidence that the concepts can be used interchangeably.
database_cross_reference: url:https://www.w3.org/2009/08/skos-reference/skos.html#exactMatch

depiction
type: AnnotationProperty
id: depiction
is metadata tag: true
shorthand: depiction

alternate name
type: AnnotationProperty

derived from
type: AnnotationProperty
python name: derived_from

has personal stake in organisation
type: ObjectProperty
sub property of: has attribute
domain: human being
range: organisation
definition: Relates a person to an organisation in the case where the person stands to gain or lose something of value resulting from the activities of the organisation or what happens to it.

has provided paid advice to organisation
type: ObjectProperty
sub property of: has attribute
domain: human being
range: organisation
definition: Relates a person to an organisation in the case where they have provided expert advice to the organisation for which they or an organisation with which they are affiliated have been paid or received benefit of monetary value.

in recent employment by organisation
type: ObjectProperty
sub property of: has attribute
domain: human being
range: organisation
definition: Relates a legal person to an organisation in the case where the legal person has, or has recently had, a role in the organisation as an employee.

has provided unpaid advice to organisation
type: ObjectProperty
sub property of: has attribute
domain: human being
range: organisation
definition: Relates a person to an organisation in the case where the person has provided expert advice to the organisation without payment or benefit to themselves or an organisation with which they are affiliated.

has received benefit from organisation
type: ObjectProperty
sub property of: has attribute
domain: human being
range: organisation
definition: Relates a person to an organisation in the case where the person or an organisation with which they are affiliated has received something of value from the organisation.

has received financial benefit from organisation
type: ObjectProperty
sub property of: has received benefit from organisation
domain: human being
range: organisation
definition: Relates a person to an organisation in the case where the person, or an organisation with which they are affiliated, has received money or something that can be exchanged for money from the organisation.

has received personal financial benefit from organisation
type: ObjectProperty
sub property of: has received financial benefit from organisation
domain: human being
range: organisation
definition: Relates a person to an organisation in the case where the person, or an organisation with which they are affiliated, has received money or something that can be exchanged for money from the organisation.

has received non-financial benefit from organisation
type: ObjectProperty
sub property of: has received benefit from organisation
domain: human being
range: organisation
definition: Relates a person to an organisation in the case where the person or an organisation with which they are affiliated has received something from the organisation that cannot be exchanged for money.

has received research support from organisation
type: ObjectProperty
sub property of: has received benefit from organisation
domain: human being
range: organisation
definition: Relates a person to an organisation in the case where the person or an organisation with which they are affiliated has received goods or services from the organisation to enable or facilitate the conduct of research in which they are involved.

is unpaid director of organisation
type: ObjectProperty
sub property of: is director of organisation
domain: human being
range: organisation
definition: is director of organisation without receiving payment.

is director of organisation
type: ObjectProperty
sub property of: has personal stake in organisation
domain: human being
range: organisation
definition: has personal stake in organisation that involves being in a director role.

through
type: ObjectProperty
domain: behaviour change intervention mechanism of action
range: entity
definition: A relation that holds between an interventions mechanism of action and an entity x, in which the entity x participates in or is part of the mechanism of action process and is influenced by a BCI or its context such that there is some change in entity x.

uses
type: ObjectProperty
sub property of: has participant
domain: individual human behaviour
range: material entity
definition: Has participant that relates a behaviour to a material entity that the person enacting the behaviour intends to enable or facilitate the behaviour.

part of
type: ObjectProperty
sub property of: topObjectProperty
editor preferred label: is part of
example of usage: my brain is part of my body (continuant parthood, two material entities)
example of usage: my stomach cavity is part of my stomach (continuant parthood, immaterial entity is part of material entity)
example of usage: this day is part of this year (occurrent parthood)
definition: a core relation that holds between a part and its whole
editor note: Everything is part of itself. Any part of any part of a thing is itself part of that thing. Two distinct things cannot be part of each other.
editor note: Occurrents are not subject to change and so parthood between occurrents holds for all the times that the part exists. Many continuants are subject to change, so parthood between continuants will only hold at certain times, but this is difficult to specify in OWL. See http://purl.obolibrary.org/obo/ro/docs/temporal-semantics/
editor note: Parthood requires the part and the whole to have compatible classes: only an occurrent can be part of an occurrent; only a process can be part of a process; only a continuant can be part of a continuant; only an independent continuant can be part of an independent continuant; only an immaterial entity can be part of an immaterial entity; only a specifically dependent continuant can be part of a specifically dependent continuant; only a generically dependent continuant can be part of a generically dependent continuant. (This list is not exhaustive.) A continuant cannot be part of an occurrent: use 'participates in'. An occurrent cannot be part of a continuant: use 'has participant'. A material entity cannot be part of an immaterial entity: use 'has location'. A specifically dependent continuant cannot be part of an independent continuant: use 'inheres in'. An independent continuant cannot be part of a specifically dependent continuant: use 'bearer of'.
alternative term: part_of
RO_0001900: RO_0001901

has part
type: ObjectProperty
sub property of: topObjectProperty
editor preferred label: has part
example of usage: my body has part my brain (continuant parthood, two material entities)
example of usage: my stomach has part my stomach cavity (continuant parthood, material entity has part immaterial entity)
example of usage: this year has part this day (occurrent parthood)
definition: A core relation that holds between a whole and its part
definition: a core relation that holds between a whole and its part
editor note: Everything has itself as a part. Any part of any part of a thing is itself part of that thing. Two distinct things cannot have each other as a part.
editor note: Occurrents are not subject to change and so parthood between occurrents holds for all the times that the part exists. Many continuants are subject to change, so parthood between continuants will only hold at certain times, but this is difficult to specify in OWL. See http://purl.obolibrary.org/obo/ro/docs/temporal-semantics/
editor note: Parthood requires the part and the whole to have compatible classes: only an occurrent have an occurrent as part; only a process can have a process as part; only a continuant can have a continuant as part; only an independent continuant can have an independent continuant as part; only a specifically dependent continuant can have a specifically dependent continuant as part; only a generically dependent continuant can have a generically dependent continuant as part. (This list is not exhaustive.) A continuant cannot have an occurrent as part: use 'participates in'. An occurrent cannot have a continuant as part: use 'has participant'. An immaterial entity cannot have a material entity as part: use 'location of'. An independent continuant cannot have a specifically dependent continuant as part: use 'bearer of'. A specifically dependent continuant cannot have an independent continuant as part: use 'inheres in'.
alternative term: has_part
RO_0001900: RO_0001901

realised in
type: ObjectProperty
sub property of: topObjectProperty
editor preferred label: realized in
example of usage: this disease is realized in this disease course
example of usage: this fragility is realized in this shattering
example of usage: this investigator role is realized in this investigation
definition: Inverse of realizes relation.
alternative term: is realized by
alternative term: realized_in
elucidation: [copied from inverse property 'realizes'] to say that b realizes c at t is to assert that there is some material entity d & b is a process which has participant d at t & c is a disposition or role of which d is bearer_of at t& the type instantiated by b is correlated with the type instantiated by c. (axiom label in BFO2 Reference: [059-003])
comment: Paraphrase of elucidation: a relation between a realizable entity and a process, where there is some material entity that is bearer of the realizable entity and participates in the process, and the realizable entity comes to be realized in the course of the process
label: realized in

realises
type: ObjectProperty
sub property of: topObjectProperty
editor preferred label: realizes
example of usage: this disease course realizes this disease
example of usage: this investigation realizes this investigator role
example of usage: this shattering realizes this fragility
definition: Paraphrase of elucidation: a relation between a process and a realizable entity, where there is some material entity that is bearer of the realizable entity and participates in the process, and the realizable entity comes to be realized in the course of the process
definition: To say that b realizes c at t is to assert that there is some material entity d and b is a process which has participant d at t and c is a disposition or role of which d is bearer_of at tand the type instantiated by b is correlated with the type instantiated by c.
elucidation: to say that b realizes c at t is to assert that there is some material entity d & b is a process which has participant d at t & c is a disposition or role of which d is bearer_of at t& the type instantiated by b is correlated with the type instantiated by c. (axiom label in BFO2 Reference: [059-003])
comment: Paraphrase of elucidation: a relation between a process and a realizable entity, where there is some material entity that is bearer of the realizable entity and participates in the process, and the realizable entity comes to be realized in the course of the process
label: realizes

occurs in
type: ObjectProperty
domain: occurrent
range: independent continuant
definition: b occurs_in c =def b is a process and c is a material entity or immaterial entityand there exists a spatiotemporal region r and b occupies_spatiotemporal_region r.and forall(t) if b exists_at t then c exists_at t and there exist spatial regions s and s’ where and b spatially_projects_onto s at tand c is occupies_spatial_region s’ at tand s is a proper_continuant_part_of s’ at t

has process part
type: ObjectProperty
sub property of: topObjectProperty
BFO OWL specification label: o-has-part
BFO CLIF specification label: hasOccurrentPart
example of usage: [copied from inverse property 'part of occurrent'] Mary’s 5th birthday occurrent_part_of Mary’s life
example of usage: [copied from inverse property 'part of occurrent'] The process of a footballer’s heart beating once is an occurrent part but not a temporal_part of a game of football.
example of usage: [copied from inverse property 'part of occurrent'] the first set of the tennis match occurrent_part_of the tennis match.
definition: Inverse of occurrent_part_of which is defined as: b occurrent_part_of c =Def. b is a part of c and b and c are occurrents.
definition: b has_occurrent_part c = Def. c occurrent_part_of b. (axiom label in BFO2 Reference: [007-001])
editor note: [copied from inverse property 'part of occurrent'] BFO 2 Reference: a (continuant or occurrent) part of itself. We appreciate that this is counterintuitive for some users, since it implies for example that President Obama is a part of himself. However it brings benefits in simplifying the logical formalism, and it captures an important feature of identity, namely that it is the limit case of mereological inclusion.
editor note: [copied from inverse property 'part of occurrent'] BFO2 Reference: occurrent
elucidation: [copied from inverse property 'part of occurrent'] b occurrent_part_of c =Def. b is a part of c & b and c are occurrents. (axiom label in BFO2 Reference: [003-002])
has associated axiom(fol): (iff (hasOccurrentPart a b) (occurrentPartOf b a)) // axiom label in BFO2 CLIF: [007-001]
label: has occurrent part

Axiom
annotated source: has process part
annotated property: definition
annotated target: b has_occurrent_part c = Def. c occurrent_part_of b. (axiom label in BFO2 Reference: [007-001])
IAO_0010000: http://purl.obolibrary.org/obo/bfo/axiom/007-001

Axiom
annotated source: has process part
annotated property: has associated axiom(fol)
annotated target: (iff (hasOccurrentPart a b) (occurrentPartOf b a)) // axiom label in BFO2 CLIF: [007-001]
IAO_0010000: http://purl.obolibrary.org/obo/bfo/axiom/007-001

has process attribute
type: ObjectProperty
sub property of: topObjectProperty
BFO OWL specification label: has-profile
definition: Inverse of process_profile_of
label: has profile

is process attribute of
type: ObjectProperty
definition: inverse of has_process_profile

is about
type: ObjectProperty
sub property of: topObjectProperty
example of usage: This document is about information artifacts and their representations
has curation status: IAO_0000125
definition: A (currently) primitive relation that relates an information artifact to an entity.
definition: Is about is a (currently) primitive relation that relates an information artifact to an entity.
editor note: 7/6/2009 Alan Ruttenberg. Following discussion with Jonathan Rees, and introduction of "mentions" relation. Weaken the is_about relationship to be primitive. We will try to build it back up by elaborating the various subproperties that are more precisely defined. Some currently missing phenomena that should be considered "about" are predications - "The only person who knows the answer is sitting beside me" , Allegory, Satire, and other literary forms that can be topical without explicitly mentioning the topic.
definition editor: person:Alan Ruttenberg
definition source: Smith, Ceusters, Ruttenberg, 2000 years of philosophy

is attribute of
type: ObjectProperty
sub property of: topObjectProperty
editor preferred label: inheres in
example of usage: this fragility is a characteristic of this vase
example of usage: this red color is a characteristic of this apple
definition: A relation between a specifically dependent continuant (the characteristic) and any other entity (the bearer), in which the characteristic depends on the bearer for its existence.
definition: a relation between a specifically dependent continuant (the characteristic) and any other entity (the bearer), in which the characteristic depends on the bearer for its existence.
alternative term: inheres_in
RO_0001900: RO_0001901
comment: Note that this relation was previously called "inheres in", but was changed to be called "characteristic of" because BFO2 uses "inheres in" in a more restricted fashion. This relation differs from BFO2:inheres_in in two respects: (1) it does not impose a range constraint, and thus it allows qualities of processes, as well as of information entities, whereas BFO2 restricts inheres_in to only apply to independent continuants (2) it is declared functional, i.e. something can only be a characteristic of one thing.
label: characteristic of

has attribute
type: ObjectProperty
sub property of: topObjectProperty
editor preferred label: bearer of
example of usage: this apple is bearer of this red color
example of usage: this vase is bearer of this fragility
definition: A relation between an independent continuant (the bearer) and a specifically dependent continuant (the dependent), in which the dependent specifically depends on the bearer for its existence
definition: Inverse of characteristic_of
editor note: A bearer can have many dependents, and its dependents can exist for different periods of time, but none of its dependents can exist when the bearer does not exist.
alternative term: bearer_of
alternative term: is bearer of
RO_0001900: RO_0001901
label: has characteristic

participates in
type: ObjectProperty
sub property of: topObjectProperty
editor preferred label: participates in
example of usage: this blood clot participates in this blood coagulation
example of usage: this input material (or this output material) participates in this process
example of usage: this investigator participates in this investigation
definition: A relation between a continuant and a process, in which the continuant is somehow involved in the process
definition: a relation between a continuant and a process, in which the continuant is somehow involved in the process
alternative term: participates_in

has participant
type: ObjectProperty
sub property of: topObjectProperty
editor preferred label: has participant
example of usage: this blood coagulation has participant this blood clot
example of usage: this investigation has participant this investigator
example of usage: this process has participant this input material (or this output material)
definition: a relation between a process and a continuant, in which the continuant is somehow involved in the process
editor note: Has_participant is a primitive instance-level relation between a process, a continuant, and a time at which the continuant participates in some way in the process. The relation obtains, for example, when this particular process of oxygen exchange across this particular alveolar membrane has_participant this particular sample of hemoglobin at this particular time.
alternative term: has_participant
source: http://www.obofoundry.org/ro/#OBO_REL:has_participant

has quality
type: ObjectProperty
sub property of: has attribute
example of usage: this apple has quality this red color
definition: a relation between an independent continuant (the bearer) and a quality, in which the quality specifically depends on the bearer for its existence
editor note: A bearer can have many qualities, and its qualities can exist for different periods of time, but none of its qualities can exist when the bearer does not exist.
alternative term: has_quality

has role
type: ObjectProperty
sub property of: has attribute
example of usage: this person has role this investigator role (more colloquially: this person has this role of investigator)
definition: a relation between an independent continuant (the bearer) and a role, in which the role specifically depends on the bearer for its existence
editor note: A bearer can have many roles, and its roles can exist for different periods of time, but none of its roles can exist when the bearer does not exist. A role need not be realized at all the times that the role exists.
alternative term: has_role

has disposition
type: ObjectProperty
sub property of: has attribute
definition: A relation between an independent continuant (the bearer) and a disposition, in which the disposition specifically depends on the bearer for its existence
definition: a relation between an independent continuant (the bearer) and a disposition, in which the disposition specifically depends on the bearer for its existence

derives from
type: ObjectProperty
sub property of: topObjectProperty
example of usage: this cell derives from this parent cell (cell division)
example of usage: this nucleus derives from this parent nucleus (nuclear division)
has curation status: IAO_0000125
definition: a relation between two distinct material entities, the new entity and the old entity, in which the new entity begins to exist when the old entity ceases to exist, and the new entity inherits the significant portion of the matter of the old entity
editor note: This is a very general relation. More specific relations are preferred when applicable, such as 'directly develops from'.
alternative term: derives_from

obsolete contains
type: ObjectProperty
sub property of: topObjectProperty
editor preferred label: contains
deprecated: true

located in
type: ObjectProperty
sub property of: topObjectProperty
editor preferred label: located in
example of usage: my brain is located in my head
example of usage: this rat is located in this cage
definition: A relation between two independent continuants, the target and the location, in which the target is entirely within the location
definition: a relation between two independent continuants, the target and the location, in which the target is entirely within the location
editor note: Location as a relation between instances: The primitive instance-level relation c located_in r at t reflects the fact that each continuant is at any given time associated with exactly one spatial region, namely its exact location. Following we can use this relation to define a further instance-level location relation - not between a continuant and the region which it exactly occupies, but rather between one continuant and another. c is located in c1, in this sense, whenever the spatial region occupied by c is part_of the spatial region occupied by c1. Note that this relation comprehends both the relation of exact location between one continuant and another which obtains when r and r1 are identical (for example, when a portion of fluid exactly fills a cavity), as well as those sorts of inexact location relations which obtain, for example, between brain and head or between ovum and uterus
editor note: Most location relations will only hold at certain times, but this is difficult to specify in OWL. See http://purl.obolibrary.org/obo/ro/docs/temporal-semantics/
alternative term: located_in
RO_0001900: RO_0001901
source: http://www.obofoundry.org/ro/#OBO_REL:located_in

happens during
type: ObjectProperty
domain: occurrent
range: occurrent
definition: X happens_during Y iff: (start(Y) before_or_simultaneous_with start(X)) AND (end(X) before_or_simultaneous_with end(Y))

temporally related to
type: ObjectProperty
sub property of: topObjectProperty
has curation status: IAO_0000125
definition editor: https://orcid.org/0000-0002-6601-2165
definition source: Allen's interval algebra
curator note: Do not use this relation directly. It is ended as a grouping for relations between occurrents involving the relative timing of their starts and ends.
source: https://docs.google.com/document/d/1kBv1ep_9g3sTR-SD3jqzFqhuwo9TPNF-l-9fUDbO6rM/edit
in_subset: ro-eco
comment: A relation that holds between two occurrents. This is a grouping relation that collects together all the Allen relations.

starts
type: ObjectProperty
sub property of: temporally related to
domain: occurrent
range: occurrent
definition: inverse of starts with

ends
type: ObjectProperty
sub property of: temporally related to
domain: occurrent
range: occurrent
definition: inverse of ends with

has output
type: ObjectProperty
sub property of: has participant
has curation status: IAO_0000125
definition: P has output c iff c is a participant in p, c is present at the end of p, and c is not present at the beginning of p.
definition: p has output c iff c is a participant in p, c is present at the end of p, and c is not present in the same state at the beginning of p.
definition editor: https://orcid.org/0000-0002-6601-2165
alternative term: produces
in_subset: valid for go annotation extension
in_subset: valid for go ontology
in_subset: valid for gocam
in_subset: ro-eco

functionally related to
type: ObjectProperty
sub property of: topObjectProperty
definition: A grouping relationship for any relationship directly involving a function, or that holds because of a function of one of the related entities.
definition editor: https://orcid.org/0000-0002-6601-2165
curator note: This is a grouping relation that collects relations used for the purpose of connecting structure and function

output of
type: ObjectProperty
sub property of: participates in
sub property of: functionally related to
definition: Inverse of has output relation
definition: inverse of has output
definition editor: https://orcid.org/0000-0002-6601-2165
in_subset: RO_0002259
in_subset: ro-eco

causally related to
type: ObjectProperty
sub property of: topObjectProperty
definition: relation that links two events, processes, states, or objects such that one event, process, state, or object (a cause) contributes to the production of another event, process, state, or object (an effect) where the cause is partly or wholly responsible for the effect, and the effect is partly or wholly dependent on the cause.
editor note: This branch of the ontology deals with causal relations between entities. It is divided into two branches: causal relations between occurrents/processes, and causal relations between material entities. We take an 'activity flow-centric approach', with the former as primary, and define causal relations between material entities in terms of causal relations between occurrents. To define causal relations in an activity-flow type network, we make use of 3 primitives: * Temporal: how do the intervals of the two occurrents relate? * Is the causal relation regulatory? * Is the influence positive or negative? The first of these can be formalized in terms of the Allen Interval Algebra. Informally, the 3 bins we care about are 'direct', 'indirect' or overlapping. Note that all causal relations should be classified under a RO temporal relation (see the branch under 'temporally related to'). Note that all causal relations are temporal, but not all temporal relations are causal. Two occurrents can be related in time without being causally connected. We take causal influence to be primitive, elucidated as being such that has the upstream changed, some qualities of the donwstream would necessarily be modified. For the second, we consider a relationship to be regulatory if the system in which the activities occur is capable of altering the relationship to achieve some objective. This could include changing the rate of production of a molecule. For the third, we consider the effect of the upstream process on the output(s) of the downstream process. If the level of output is increased, or the rate of production of the output is increased, then the direction is increased. Direction can be positive, negative or neutral or capable of either direction. Two positives in succession yield a positive, two negatives in succession yield a positive, otherwise the default assumption is that the net effect is canceled and the influence is neutral. Each of these 3 primitives can be composed to yie…
definition editor: https://orcid.org/0000-0002-6601-2165
curator note: Do not use this relation directly. It is intended as a grouping for a diverse set of relations, all involving cause and effect.

Axiom
annotated source: causally related to
annotated property: definition
annotated target: relation that links two events, processes, states, or objects such that one event, process, state, or object (a cause) contributes to the production of another event, process, state, or object (an effect) where the cause is partly or wholly responsible for the effect, and the effect is partly or wholly dependent on the cause.
database_cross_reference: https://en.wikipedia.org/wiki/Causality

causal relation between entities
type: ObjectProperty
sub property of: causally related to
domain: entity
range: entity
editor note: The intent is that the process branch of the causal property hierarchy is primary (causal relations hold between occurrents/processes), and that the material branch is defined in terms of the process branch
definition editor: https://orcid.org/0000-0002-6601-2165
definition source: causal-relations
curator note: Do not use this relation directly. It is intended as a grouping for a diverse set of relations, all involving cause and effect.

causally influenced by
type: ObjectProperty
sub property of: causal relation between entities
domain: process
range: disposition
definition editor: https://orcid.org/0000-0002-6601-2165
definition source: causal-relations
OBO foundry unique label: causally influenced by (entity-centric)

7-day point prevalence tobacco smoking abstinence
type: Class
subclass of: point prevalence tobacco smoking abstinence
has curation status: Proposed
definition: Point prevalence tobacco smoking abstinence that lasts for 7 days prior to a time point.

tobacco use abstinence
type: Class
subclass of: abstinence from a behaviour
has curation status: Proposed
definition: Abstinence from a behaviour where the behaviour is tobacco use.

percent abstinent
type: Class
subclass of: data item
has curation status: Proposed
definition: A data item that is about a population attribute of the percentage of the population that are abstinent from a behaviour over a period of time.

ad lib substance use
type: Class
subclass of: substance use behaviour pattern
has curation status: Proposed
definition: A substance use behaviour pattern in which each episode is determined by factors operating at the time rather than according to a planned schedule.

addictiveness of a behaviour
type: Class
subclass of: behavioural attribute
has curation status: Discussed
definition: A behavioural attribute that is the extent to which it results in addiction in people who engage in it.
alternative term: addictiveness
curator note: The parent term 'behavioural attribute' in the Behaviour Change Intervention Ontology.
comment: We often refer to 'addictiveness' of drugs, but this is imprecise and inaccurate because it is the behaviour of ingesting a particular drug formulation in a particular way to which people become addicted. For example, people talk about nicotine having high addictiveness, but it is particular behaviours that involve ingesting nicotine (e.g. cigarette smoking) that are addictive while others (e.g. putting on a nicotine transdermal patch) are not.

adolescent alcohol consumption
type: Class
equivalent class: Class
  intersection of: alcohol consumption
  intersection of: Restriction
    on property: has participant
    some values from: adolescent
subclass of: adolescent substance use
subclass of: alcohol consumption
has curation status: Proposed
definition: Alcohol consumption by an adolescent.
alternative term: Adolescent drinking
curator note: Fully defined class because it is made up of the intersection of two classes.

adolescent substance use
type: Class
equivalent class: Class
  intersection of: substance use behaviour
  intersection of: Restriction
    on property: has participant
    some values from: adolescent
subclass of: substance use behaviour
has curation status: Discussed
definition: A substance use behaviour by an adolescent.

alcohol abstinence
type: Class
subclass of: abstinence from a behaviour
has curation status: Proposed
definition: Abstinence from a behaviour where the behaviour is consumption of an alcohol-containing drink.

alcohol and substance use pattern
type: Class
subclass of: consumption behaviour pattern
has curation status: Proposed
definition: A consumption behaviour pattern involving use of a substance containing alcohol concurrently with use of a psychoactive substance that has not been legally sanctioned in the jurisdiction in which the user resides.

alcohol consumption change
type: Class
subclass of: consumption behaviour
has curation status: Proposed
definition: A change quantity or pattern of alcohol consumption.

alcohol consumption reduction
type: Class
subclass of: consumption behaviour
has curation status: Proposed
definition: A reduction in alcohol consumption.

alcohol consumption trend
type: Class
subclass of: consumption behaviour
has curation status: Proposed
definition: A population level pattern of alcohol consumption.

alcohol initiation
type: Class
subclass of: consumption behaviour
has curation status: Proposed
definition: The first instance of alcohol consumption.

alcohol misuse
type: Class
subclass of: consumption behaviour
has curation status: Proposed
definition: Consumption of alcohol in a manner that is deemed unacceptable in the jurisdiction in which the user resides.

alcohol problem
type: Class
subclass of: behaviour attribute
has curation status: Proposed
definition: Consumption of alcohol in a manner that is deemed to cause harm to the individual, others or society.

behaviour pattern
type: Class
subclass of: process
has curation status: Proposed
definition: A process that involves repeated occurrences of a behaviour.

behavioural lapse
type: Class
subclass of: process profile
has curation status: Proposed
definition: A process profile that involves starting then stopping a behaviour following abstinence.

behavioural relapse
type: Class
subclass of: process boundary
has curation status: Proposed
definition: A process boundary that involves restarting a behaviour pattern after a period of abstinence from that behaviour pattern.

codeine use
type: Class
subclass of: drug use behaviour
has curation status: Proposed
definition: A drug use behaviour in which the drug is codeine.

gateway effect
type: Class
subclass of: process
has curation status: Discussed
definition: A process in which use of a product delivering a psychoactive substance increases the likelihood of use of another product delivering a psychoactive substance.

habitual behaviour pattern
type: Class
subclass of: behaviour pattern
has curation status: Proposed
definition: A behaviour pattern that continues over an extended period of time.

population gateway effect
type: Class
subclass of: process
has curation status: Discussed
definition: A process in which an increase in prevalence of use of a product delivering a psychoactive substance leads to an increase in the prevalence of use of another product delivering a psychoactive substance.

product-use behaviour
type: Class
subclass of: object-using behaviour
has curation status: Proposed
definition: Object-using behaviour that involves use of a product.
alternative term: Product-using behaviour
curator note: Product use behaviour is included to provide a link between product and a class of behaviour for which the relation always holds.

tobacco cessation
type: Class
subclass of: process boundary
has curation status: Proposed
definition: A process boundary that involves the end of a period of tobacco use.

tobacco smoking abstinence
type: Class
subclass of: tobacco use abstinence
has curation status: Proposed
definition: Tobacco use abstinence where the behaviour is tobacco smoking.
alternative term: tobacco abstinence.

tobacco smoking relapse
type: Class
subclass of: behavioural relapse
has curation status: Proposed
definition: Behavioural relapse that involves tobacco smoking.

12-month follow-up
type: Class
subclass of: follow-up
has curation status: Discussed
definition: Follow-up that occurs at the 12-month follow-up point.

24-month follow-up
type: Class
subclass of: follow-up
has curation status: Discussed
definition: Follow-up that occurs at the 24-month follow-up point.

28-item General Health Questionnaire
type: Class
subclass of: questionnaire
has curation status: Discussed
definition: A self-report questionnaire for identifying minor psychiatric disorders in the general population and within community or non-psychiatric clinical settings such as primary care or general medical out-patients.
alternative term: 28-item GHQ
definition source: https://www.cambridge.org/core/journals/psychological-medicine/article/scaled-version-of-the-general-health-questionnaire/855845C6B366DB4AEDD66C350320D2A9
curator note: The cross reference is a useful source of information about the questionnaire.

6-month follow-up
type: Class
subclass of: follow-up
has curation status: Discussed
definition: Follow-up that occurs at the 6-month follow-up point.

academic literature
type: Class
subclass of: literature
has curation status: Discussed
definition: Literature that is an output of academic activity.
comment: This covers the output of any academic activity, not just research.

confidence interval
type: Class
subclass of: quantitative confidence value
has curation status: Proposed
definition: A quantitative confidence value that refers to an interval give values within which there is a high probability (95 percent by convention) that the true population value can be found. The calculation of a confidence interval considers the standard deviation of the data and the number of observations. Thus, a confidence interval narrows as the number of observations increases, or its variance (dispersion) decreases.
alternative term: CI
definition source: http://purl.obolibrary.org/obo/OBCS_0000070

follow-up
type: Class
subclass of: research activity
has curation status: Discussed
definition: A research activity that involves taking a measurement after the start of an intervention or research activity.
curator note: This attempts to capture the most common usage and so distinguishes between end-of-treatment assessment and follow up.
comment: Used in longitudinal studies and intervention evaluations to capture measures taken after the start of an intervention or a baseline measure.

questionnaire
type: Class
subclass of: document
has curation status: Discussed
definition: A document that contains a set of questions.
curator note: The most iwdely used definition in OntoBee is from OBI but it is too specific.

questionnaire administration
type: Class
subclass of: process
has curation status: Discussed
definition: A process in which answers to questions in a questionnaire are obtained.

research measure
type: Class
subclass of: information content entity
has curation status: Proposed
definition: An information content entity that is used in a research study to specify how a measurement should be undertaken.
curator note: This and the one below need VERY clear labels to disambiguate

research study measurement
type: Class
subclass of: planned process
has curation status: Proposed
definition: A planned process that has as its output a data item corresponding to a quantitative or qualitative description of the attributes of an entity.
definition source: Measurement is not itself defined, except tautologically as "the data item that is the output of a measuremnet"
curator note: Why not just 'measurement'?

research study measurement datum
type: Class
subclass of: measurement datum
has curation status: Proposed
definition: A measurment datum that is produced as part of a research study.

self-report questionnaire
type: Class
subclass of: questionnaire administration
has curation status: Discussed
definition: A questionnaire administration in which the person completing the questionnaire is answering questions about themselves.

start of follow-up period
type: Class
subclass of: temporal start
has curation status: Discussed
definition: The process boundary at the beginning of a follow-up period.

temporal start
type: Class
subclass of: process boundary
has curation status: Discussed
definition: The process boundary when a process or temporal region starts.
definition source: AFP:0003328
curator note: Definition from AFP modified to include temporal region.

3-way statistical interaction
type: Class
subclass of: statistical interaction
has curation status: Discussed
definition: A statistical interaction between three variables.

scientific model
type: Class
subclass of: generically dependent continuant
has curation status: Proposed
definition: A generically dependent continuant that is a representation or abstraction of a portion of reality, is created by a cognitive agent or group of agents through a process of scientific enquiry, and serves to explain, predict or describe phenomena within a specified domain.

addiction relapse case
type: Class
subclass of: data item
has curation status: Proposed
definition: A data item that represents a human being who has received an intervention intended to result in cessation of an addictive behaviour and who, after a period of abstinence, has resumed the behaviour.

addiction research
type: Class
subclass of: research activity
has curation status: Proposed
definition: Research activity about addiction.
definition source: NCIT defines research as "Systematic investigation into a subject in order to discover facts, establish or revise a theory, or develop a plan of action based on the facts discovered."

analytic toxicologist
type: Class
subclass of: human being
has curation status: Proposed
definition: A person who has analytic toxicologist role.

biological sample
type: Class
subclass of: role
has curation status: Proposed
definition: A sample is a substance role played by a biological substance as an input substance to a protocol.
curator note: The definition and link to role is coherent with BFO but the ontology itself is probably not suitable to be imported.

experimental manipulation
type: Class
subclass of: research activity
has curation status: Proposed
definition: A research activity that forms part of a research study that aims to influence an outcome.
curator note: BCIO?

follow-up period
type: Class
subclass of: temporal region
example of usage: The follow up period was for 12 months from the offer of a prescription for varenicline.
has curation status: Discussed
definition: A temporal region between a research activity and a follow-up.
comment: The temporal period is often counted from the start of an intervention even though the definition of follow up states that it takes place after the end of an intervention.

grey literature
type: Class
subclass of: research literature
has curation status: Discussed
definition: Research literature whose constituent documents have not been published in a peer-reviewed journal.

literature
type: Class
subclass of: information content entity
has curation status: Discussed
definition: An information content entity that is an aggregate of documents.

simulated population
type: Class
subclass of: information content entity
has curation status: Proposed
definition: An information content entity that represents attributes of a population for the purposes of modelling processes or outcomes in that population.

validated measure
type: Class
subclass of: research measure
has curation status: Proposed
definition: A research measure that has been subjected to evaluation for one or more forms of validity and which it is claimed has reached or exceeded an appropriate threshold on that criterion.

work absence register
type: Class
subclass of: data item
has curation status: Proposed
definition: A database documenting absence from work
alternative term: Absence register

year of publication
type: Class
subclass of: data item
has curation status: Discussed
definition: A data item that is the year in which a document was published.

personal financial stake
type: Class
subclass of: personal stake
has curation status: Proposed
definition: A personal stake in which the value to the person involves money or something of monetary value.

disclosure of potential competing interest
type: Class
subclass of: report
has curation status: Proposed
definition: A report that provides information about a person's potential competing interest.
comment: Good practice involves being as inclusive as possible to ensure full transparency and include both financial and non-financial attributes that might conceivably influence the conduct, reporting or evaluation of research whether or not it actually does so.

personal stake
type: Class
subclass of: personal attribute
example of usage: Dr Smith has a personal stake in the outcome of the clinical trial of the drug, varenicline, because he has shares in the company that produces the drug.
has curation status: Proposed
definition: A personal attribute in relation to an activity such that an outcome of the activity has value for the person.
comment: This is a relational attribute that links a person to an activity (not necessarily one that they are engaged in). Value here can be positive or negative. The value need not be recognised by the person involved.

tobacco industry funding
type: Class
subclass of: generically dependent continuant
has curation status: Proposed
definition: Funding that originates from one or more tobacco companies.

population-level harm from product use
type: Class
subclass of: data item
has curation status: Discussed
definition: A process aggregate of harm processes affecting some members of a population caused by product use by some members of the population.

individual-level relative harmfulness to health of a product
type: Class
subclass of: data item
has curation status: Discussed
definition: A data item that is about the amount of harm to health caused by an individual using a product relative to other products.

abuse potential of a substance
type: Class
subclass of: product harm potential
has curation status: Discussed
definition: A psychoactive substance disposition that is its propensity to lead people who use the substance to develop a harmful pattern of consumption.
alternative term: abuse liability of a substance

adjustable power e-cigarette atomiser
type: Class
subclass of: e-cigarette atomiser
has curation status: Discussed
definition: An e-cigarette atomiser which the user can adjust to different levels of power.
alternative term: adjustable power atomiser

anticonvulsant drug
type: Class
subclass of: central nervous system depressant
has curation status: Discussed
definition: A central nervous system depressant that is used to prevent seizures or reduce their severity.
definition source: CHEBI:35623
curator note: Taken from ChEBI but slight edited for consistency.

brand
type: Class
subclass of: information content entity
has curation status: Discussed
definition: An information content entity that is used by a person or organisation to denote and promote a product.
alternative term: Brand name

cannabis extract
type: Class
subclass of: plant extract
subclass of: Restriction
  on property: has role
  some values from: psychoactive substance
has curation status: Published
definition: A plant extract from the cannabis plant.
alternative term: cannabis

cannabis concentrate
type: Class
subclass of: cannabis extract
has curation status: Discussed
definition: A cannabis extract that has been processed to contain a high concentration of cannabinoids.
alternative term: concentrates
comment: It is important to clarify what cannabinoids are included.

cannabis potency
type: Class
subclass of: data item
has curation status: Discussed
definition: A data item that is the concentration of cannabinoids in a cannabis product.

chewing tobacco product
type: Class
subclass of: oral tobacco-containing product
has curation status: Published
definition: An oral tobacco-containing product that is manufactured to be chewed.
definition source: https://www.cancer.gov/publications/dictionaries/cancer-terms/def/chewing-tobacco
comment: Consists of loose tobacco leaves, pellets or “bits” (leaf tobacco rolled into small pellets), plugs (leaf tobacco pressed and held together with a sweetener), or twists (leaf tobacco rolled into rope-like strands and twisted).

cigar
type: Class
subclass of: combustible tobacco-containing product
has curation status: Published
definition: A combustible tobacco-containing product that is a cylinder formed of chopped tobacco encased in tobacco leaf.
comment: The user sets one end alight and ingests smoke by sucking on the other end. The cylinder becomes shorter as the tobacco burns to smoke and ash until either the user extinguishes the burning tobacco or all the tobacco is burnt. This definition includes large panatelas and small cigars. Cigars typically produce smoke with a high concentration of nicotine so that a significant amount of nicotine can be absorbed through the lining of the mouth without the smoke having to be inhaled into the lungs.

cigarette
type: Class
subclass of: combustible tobacco-containing product
has curation status: Published
definition: A combustible tobacco-containing product that is a thin cylinder of finely cut tobacco encased in a thin paper.
comment: The user sets one end alight and ingests smoke by sucking on the other end. The cylinder becomes shorter as the tobacco burns to smoke and ash until either the user extinguishes the burning tobacco or all the tobacco is burnt. This definition includes hand-rolled cigarettes and manufactured cigarettes but not cigarillos, bidis or small cigars. Cigarettes are typically made for the smoke to be inhaled into the lungs.

cigarette brand
type: Class
subclass of: brand
has curation status: Discussed
definition: A brand that is applied to a manufactured cigarette.
alternative term: tobacco brand

cigarette smoke
type: Class
subclass of: tobacco smoke
has curation status: Published
definition: Smoke that is produced through the use of a cigarette.
alternative term: smoke

cigarette smoke ingredient
type: Class
subclass of: chemical substance
has curation status: Discussed
definition: A chemical substance that is part of cigarette smoke.

codeine pharmaceutical
type: Class
subclass of: pharmaceutical
has curation status: Discussed
definition: A pharmaceutical that contains codeine.

combustible tobacco-containing product
type: Class
subclass of: tobacco-containing product
has curation status: Published
definition: A tobacco-containing product in which the tobacco is processed to make it suitable for burning for the user to take the smoke into the body.
alternative term: combustible tobacco

drug metabolite
type: Class
subclass of: chemical substance
has curation status: Published
definition: A chemical substance that is metabolite of a drug.

e-cigarette atomiser
type: Class
subclass of: product
has curation status: Published
definition: A product that is manufactured to be part of an e-cigarette and to heat e-liquid during e-cigarette use to produce a vapour.

e-cigarette battery
type: Class
subclass of: electrical battery
subclass of: Restriction
  on property: has disposition
  some values from: e-cigarette battery power
has curation status: Published
definition: An electrical battery that is designed to be part of an e-cigarette and provide electrical energy for an e-cigarette atomiser.

e-cigarette brand
type: Class
subclass of: brand
has curation status: Discussed
definition: A brand of e-cigarette.
alternative term: vape brand

e-cigarette cartridge
type: Class
subclass of: product
has curation status: Published
definition: A product that is a part of an e-cigarette and consists of an e-cigarette atomiser surrounded by a liquid-soaked poly-foam that acts as an e-liquid holder.

e-cigarette fire
type: Class
subclass of: fire
has curation status: Discussed
definition: A fire that is caused by malfunction of an e-cigarette or a part of an e-cigarette.

e-liquid container
type: Class
subclass of: product
has curation status: Published
definition: A product that is manufactured to be part of an e-cigarette and contain e-liquid.

e-liquid flavouring
type: Class
subclass of: chemical substance
subclass of: Restriction
  on property: part of
  some values from: e-liquid
has curation status: Published
definition: A chemical substance that is designed to be part of an e-liquid to impart a flavour to the vapour produced when the e-liquid is used in an e-cigarette.

e-cigarette microprocessor
type: Class
subclass of: product
has curation status: Discussed
definition: A product that is a microchip that is a part of an e-cigarettes and is designed to record its use.

e-cigarette mouthpiece
type: Class
subclass of: product
has curation status: Discussed
definition: A product that is an e-cigarette part and is designed to be placed to the mouth of the user through which to inhale the vapour.

e-cigarette replaceable coil
type: Class
subclass of: e-cigarette atomiser
has curation status: Discussed
definition: An e-cigarette atomiser that is designed to be replaceable.
alternative term: atomiser

e-cigarette starter kit
type: Class
subclass of: product
has curation status: Discussed
definition: A product that is an e-cigarette together with packing, instructions and spare parts required to use the e-cigarette for an initial period.
alternative term: vaping starter pack

e-cigarette tank
type: Class
subclass of: product
has curation status: Discussed
definition: A product that is designed to be an e-cigarette part that is a container to hold e-liquid.
alternative term: e-liquid tank

e-cigarette vapour
type: Class
subclass of: aerosol
has curation status: Discussed
definition: An aerosol produced by heating an e-liquid designed for use in an e-cigarette.
alternative term: aerosol

e-cigarette vapour component
type: Class
subclass of: chemical substance
has curation status: Discussed
definition: A chemical substance that is part of e-cigarette vapour.

electronic heated vaping device
type: Class
subclass of: vaping device
has curation status: Published
definition: A vaping device that produces vapour by electrically heating a substance that is an e-liquid or a solid.
alternative term: vaping device
comment: This does not include electronic vaping devices that do not heat a liquid to produce the vapour.

e-liquid
type: Class
subclass of: liquid commodity
has curation status: Published
definition: A liquid commodity that is used in e-cigarettes for the purpose of aerosolization and inhalation by a person.
comment: Typically consists of propylene glycol or glycerol together with nicotine and flavourants.

e-liquid ingredient
type: Class
subclass of: chemical substance
has curation status: Published
definition: A chemical substance that is manufactured for use as part of an e-liquid.

e-liquid nicotine concentration
type: Class
subclass of: concentration
has curation status: Published
definition: The concentration of nicotine in a portion of e-liquid.
alternative term: e-liquid strength

e-liquid refill
type: Class
subclass of: e-liquid
has curation status: Discussed
definition: An e-liquid that is designed to be used with an electronic vaping device to replace the liquid in the tank of that device that has been used.

environmental tobacco smoke
type: Class
subclass of: smoke
has curation status: Discussed
definition: Smoke that is produced through the burning of a combustible tobacco-containing product and released into the environment.

fixed power e-cigarette atomiser
type: Class
subclass of: e-cigarette atomiser
has curation status: Discussed
definition: An e-cigarette atomiser which has only one power level.
alternative term: fixed-power atomiser

flavoured e-liquid
type: Class
subclass of: e-liquid
subclass of: Restriction
  on property: has part
  some values from: e-liquid flavouring
has curation status: Published
definition: An e-liquid that has e-liquid flavouring.
alternative term: flavoured liquid

fruit flavoured e-liquid
type: Class
subclass of: flavoured e-liquid
has curation status: Published
definition: A flavoured e-liquid in which the e-liquid flavouring is designed to have a fruit flavour.
alternative term: fruit flavoured liquid

population-level relative harm from product use
type: Class
subclass of: data item
has curation status: Discussed
definition: A data item that is about the population-level harm from product use of one product compared with another.

individual health risk
type: Class
subclass of: bodily disposition
has curation status: Published
definition: A bodily disposition that is a person's likelihood of an adverse health outcome.
comment: Every person has this disposition to a greater or lesser extent at any given time in any given context. The term is only meaningful when operationalised to specify the nature of the risk and the timescale.

heated tobacco product
type: Class
subclass of: tobacco-containing product
has curation status: Published
definition: A tobacco-containing product that contains a tobacco stick that it heats to cause minimal or no combustion to produce smoke or a vapour for inhalation by a person.
comment: This product is described as not involving combustion of tobacco and thereby avoiding production of harmful chemicals caused by combustion such as carbon monoxide. However for at least some products there is some evidence of a degree of combustion.

heated tobacco stick
type: Class
subclass of: product
has curation status: Published
definition: A product that is formed of tobacco processed in such a way as to make it suitable to be used in a heated tobacco-containing product.
alternative term: heet stick

high nicotine concentration e-liquid
type: Class
subclass of: nicotine-containing e-liquid
has curation status: Published
definition: A nicotine-containing e-liquid in which the e-liquid nicotine concentration is high.

iQOS
type: Class
subclass of: heated tobacco product
has curation status: Published
definition: A heated tobacco-containing product that involves heating a heated tobacco stick to up to 350 degrees centigrade using power from a battery. It is marketed by Philip Morris under the brand name iQOS.
curator note: iQOS is marketed as a product that has substantially lower harmfulness than cigarettes. This is a matter for empirical evidence and therefore not included in the definition, which aims solely to unambiguously identify the entity.

licensed nicotine-containing product
type: Class
equivalent class: Class
  intersection of: nicotine-containing product
  intersection of: licensed drug
subclass of: nicotine-containing product
subclass of: licensed drug
has curation status: Published
definition: A nicotine-containing product that is a licensed drug
alternative term: LNP

mainstream smoke
type: Class
subclass of: environmental tobacco smoke
has curation status: Proposed
definition: An environmental tobacco smoke that is produced by a person from the lighting of a combustible tobacco product, it is inhaled by the person and exhaled into the environment.

manufactured cigarette
type: Class
subclass of: cigarette
subclass of: Restriction
  on property: has disposition
  some values from: manufactured cigarette disposition
has curation status: Published
definition: A cigarette that is manufactured in a factory.
alternative term: factory-made cigarette

marlboro Red
type: Class
subclass of: cigarette brand
has curation status: Proposed
definition: A cigarette brand colour that is closely associated with Marlboro cigarettes.

nicotine-containing product
type: Class
subclass of: product
subclass of: Restriction
  on property: has part
  some values from: nicotine
has curation status: Published
definition: A product that includes or contains nicotine.
alternative term: nicotine product
curator note: The relation with 'nicotine' is 'has part' and not 'contains' because contains is reserved for spatially enclosing a separate entity.
comment: This class overlaps with tobacco-containing product but is distinct from it as tobacco-containing products can have the nicotine removed and nicotine-containing products may not have any other tobacco constituents in them (e.g. nicotine gum).

nicotine inhalator
type: Class
subclass of: nicotine replacement therapy product
has curation status: Proposed
definition: A nicotine replacement therapy product that consists of a plastic tube which holds a replaceable nicotine cartridge which delivers nicotine orally to a person through a mouthpiece.
alternative term: Inhaler
comment: Product concentration needs to be specified

nicotine lozenge
type: Class
subclass of: nicotine replacement therapy product
has curation status: Proposed
definition: A nicotine replacement therapy product that delivers nicotine orally by a tablet which slowly dissolves in the mouth.
comment: Product concentration needs to be specified

nicotine nasal spray
type: Class
subclass of: nicotine replacement therapy product
has curation status: Proposed
definition: A nicotine replacement therapy product that delivers nicotine by a spray in to nose.
comment: Product concentration needs to be specified

nicotine polacrilex
type: Class
subclass of: nicotine replacement therapy product
has curation status: Proposed
definition: A nicotine replacement therapy product that delivers nicotine orally by a chewing gum.
alternative term: Nicotine gum
comment: Product concentration needs to be specified

nicotine replacement therapy
type: Class
subclass of: treatment
has curation status: Proposed
definition: Nicotine replacement therapy are nicotine delivery products that are licensed for use as smoking cessation or harm reduction aids used by people for quitting or reducing use of tobacco containing products.
alternative term: NRT products

nicotine transdermal patch
type: Class
subclass of: nicotine replacement therapy product
has curation status: Proposed
definition: A nicotine replacement therapy product that delivers nicotine through the skin by use of an adhesive patch.
alternative term: nicotine patch
comment: Product concentration needs to be specified

unflavoured e-liquid
type: Class
subclass of: e-liquid
has curation status: Published
definition: An e-liquid that does not contain any e-liquid flavouring.

oil based cannabis liquid
type: Class
subclass of: cannabis-containing e-liquid
has curation status: Proposed
definition: An liquid that is oil based and contains cannabinoids.
comment: Clarify what cannabis the oil consists of i.e. CBD or THC and where possible what %

over the counter nicotine replacement therapy
type: Class
subclass of: nicotine replacement therapy
has curation status: Proposed
definition: A nicotine replacement therapy product that can be sold to a person without the need for a prescription.

packet of cigarettes
type: Class
subclass of: combustible tobacco-containing product
subclass of: Restriction
  on property: has part
  some values from: cigarette
has curation status: Published
definition: A combustible tobacco-containing product that is manufactured as two or more cigarettes in a single container.
alternative term: packet of fags
curator note: It is important to state that it is manufactured as containing two or more cigarettes because the number actually in the pack depends on how many have been used. It is also important to be clear that it includes the cigarettes and not just the pack. A different term (cigarette pack) has to be used for the container. For AddictO the parent of interest relates to tobacco rather than more general types of pack.
comment: The entity in this case is the pack plus cigarettes manufactured within it. Cigarettes are 'part of' the pack rather than contained within it because the pack is both the packaging and the cigarettes.

cigarette pack size
type: Class
subclass of: data item
has curation status: Discussed
definition: A data item that is the number of cigarettes that are sold in a packet of cigarettes.
alternative term: pack size

pharmaceutical formulation
type: Class
subclass of: data item
has curation status: Discussed
definition: A data item that describes the composition of a pharmaceutical.
definition source: https://www.ebi.ac.uk/ols/ontologies/ncit/terms
curator note: Much of the NCIT definition as been used but not all because it does not quite capture what is needed.

PM2.5 particulate matter
type: Class
subclass of: airborne particulate matter
has curation status: Discussed
definition: Airborne particulate matter in which the particles are less than or equal to 2.5 microns in size.

prescription-only medicine
type: Class
subclass of: medicine
has curation status: Proposed
definition: A medicine that is licensed in a jurisdiction only to be provided under authorisation of a prescription from a medical practitioner.

prescription nicotine replacement therapy
type: Class
subclass of: nicotine replacement therapy
has curation status: Proposed
definition: A nicotine replacement therapy that is prescribed to a person by a medical practitioner.
alternative term: Prescription NRT

producer of product
type: Class
subclass of: role
has curation status: Proposed
definition: A role performed by an organisation or individual who participates in processes that bring the product into existence or purpose it as a product.

product
type: Class
subclass of: artifact
subclass of: Restriction
  on property: has role
  some values from: product role
has curation status: Published
definition: An artifact that has a product role.
definition source: DOI: 10.3233/AO-190210
curator note: This entity is the one specified in the Product Life Cycle Ontologies. It could not be imported because those ontologies do not conform to the OBO Foundry standard.
comment: This entity only includes objects. Commodities and intangible entities such as software are classified separately.

rebuildable e-cigarette atomiser
type: Class
subclass of: e-cigarette atomiser
has curation status: Proposed
definition: An e-cigarette atomiser which is built by the end user.
alternative term: RDA

roll-your-own tobacco
type: Class
subclass of: combustible tobacco-containing product
has curation status: Proposed
definition: A tobacco-containing product that consists of chopped tobacco processed in a way to make it suitable for including in a hand-rolled cigarette.
alternative term: roll your own
comment: Roll your own tobacco also known as loose tobacco and used within pipes.

sidestream smoke
type: Class
subclass of: environmental tobacco smoke
has curation status: Proposed
definition: An environmental tobacco smoke that is produced upon the lighting of a combustible tobacco-containing product and is released into the environment.
comment: Sidestream smoke is contrasted with mainstream smoke.

sinsemilla
type: Class
subclass of: cannabis
has curation status: Proposed
definition: highly potent marijuana from female plants that are specially tended and kept seedless by preventing pollination to induce a high resin content
alternative term: skunk
definition source: https://www.merriam-webster.com/dictionary/sinsemilla

smokeless tobacco-containing product
type: Class
subclass of: tobacco-containing product
has curation status: Published
definition: A tobacco-containing product in which the tobacco is processed to enable absorption of a some tobacco constituent through an epithelial membrane.
alternative term: smokeless tobacco
comment: This class does not include products whose only tobacco-related constituent is nicotine. Those are in the class of nicotine-containing products. It includes chewing tobacco and snus. Epithelial membranes are typically the oral and nasal mucosae.

smoking cessation aid
type: Class
subclass of: role
has curation status: Proposed
definition: A product that is used by a person for the purpose of quitting smoking.
alternative term: NRT product

nasal snuff
type: Class
subclass of: smokeless tobacco-containing product
has curation status: Published
definition: A smokeless tobacco-containing product that is formed of dry finely-ground tobacco and is placed by a person in the nasal cavity.

oral snuff
type: Class
subclass of: oral tobacco-containing product
has curation status: Published
definition: An oral tobacco-containing product that is composed mainly or exclusively of moist, ground or powdered tobacco that is processed to make it suitable for use by a person placing it in the mouth between the gum and the cheek.
alternative term: moist snuff
curator note: People often confuse oral snuff with snus and it is important to recognise that snus is a subclass of oral snuff and not the same as it.
comment: This class includes snus as well as other oral ground or powdered tobacco products that are not chewed.

squonker
type: Class
subclass of: product
has curation status: Discussed
definition: A product that is designed for use as part of an e-cigarette, having an inbuilt reservoir for e-liquid, that is fed to a dripper by either squeezing or pumping the reservoir.

sustained release drug
type: Class
subclass of: product attribute
has curation status: Proposed
definition: A drug attribute which describes the process by which a drug is released into the blood stream at a predetermined rate to maintain a specific drug concentration over a period of time.
alternative term: slow release

cannabis cart vaping device
type: Class
subclass of: cannabis vaping device
has curation status: Discussed
definition: A cannabis vaping device part that is formed of disposable non-refillable cartridge which is attached to a device for the purpose of consuming cannabis.
alternative term: vape pen, weed vape, oil vape
comment: It is important to clarify what type of cannabis product is being vaped.

cannabis containing liquid
type: Class
subclass of: liquid commodity
has curation status: Discussed
definition: A liquid that contains cannabis.

cannabis vaping device
type: Class
subclass of: vaping device
has curation status: Discussed
definition: A vaping device that is designed to be used for vaping cannabis.
alternative term: weed vape, cannabis vape

tobacco
type: Class
subclass of: commodity
subclass of: Restriction
  on property: derives from
  some values from: tobacco plant
has curation status: Published
definition: A commodity that is formed from parts of the tobacco plant.
comment: The parent class is 'commodity' to highlight the most common usage of the term in tobacco research which focuses on tobacco products that are manufactured and sold.

processed tobacco
type: Class
subclass of: tobacco
has curation status: Published
definition: Tobacco that has been processed for use in a tobacco-containing product.

tobacco plant
type: Class
subclass of: whole plant
has curation status: Published
definition: A plant of the species that belongs to the Nicotiana genus of herbaceous plants.
alternative term: Nicotiana
curator note: Although there are definitions of tobacco plant in other ontologies, these were not quite suitable for the purposes of AddictO.
comment: Nicotiana species include many varieties. These are commonly referred to as tobacco plants, and are cultivated as ornamental garden plants. N. tabacum is grown worldwide for production tobacco-containing products.

FDA-defined tobacco product
type: Class
subclass of: product
has curation status: Published
definition: A product that is classified by the US Food and Drug Administration as a tobacco product.
alternative term: tobacco product
curator note: This class is required because it is used by US the Food and Drug Administration's Center for Tobacco Products to classify products over which it has jurisdiction.
comment: An FDA defined tobacco product is any product that meets the definition of a tobacco product set out in the United States Food, Drug and Cosmetic Act and as interpreted by the courts. It is any product made or derived from tobacco that is intended for human consumption, including any component, part, or accessory of a tobacco product (except for raw materials other than tobacco used in manufacturing a component, part, or accessory of a tobacco product). It does not include an article that is a drug. This class is not coherent and is best avoided in scientific discourse because, despite the label, it includes products that have no tobacco constituents in them (e.g. e-cigarettes whose e-liquid does not contain nicotine) and excludes products that do have the tobacco constituent nicotine (e.g. nicotine gum).

cigarette pack
type: Class
subclass of: packaging
has curation status: Discussed
definition: Packaging that is designed to hold manufactured cigarettes.
alternative term: cigarette packaging

tobacco product price
type: Class
subclass of: generically dependent continuant
has curation status: Proposed
definition: The designated price of a unit of a tobacco product.

tobacco-containing product
type: Class
subclass of: product
subclass of: Restriction
  on property: has part
  some values from: tobacco
has curation status: Published
definition: A product that is made of tobacco or has tobacco as a part and is used by people to take some tobacco constituent into the body.
alternative term: tobacco product
comment: This class includes products that contain or consist of parts of the tobacco plant that have been subject to some form of processing. This class does not contain products that only contain nicotine. These are dealt with separately as 'nicotine-containing products'.

tobacco-flavoured e-liquid
type: Class
subclass of: flavoured e-liquid
has curation status: Published
definition: A flavoured e-liquid in which the e-liquid flavouring is designed to have a tobacco flavour.

tobacco-specific nitrosamine
type: Class
subclass of: nitrosamine
subclass of: Restriction
  on property: has role
  some values from: carcinogenic agent
has curation status: Proposed
definition: A nitrosamine which derives from tobacco products and tobacco smoke.
alternative term: TSNA

tobacco smoke
type: Class
subclass of: smoke
subclass of: Restriction
  on property: has part
  some values from: tobacco-specific nitrosamine
has curation status: Published
definition: Smoke that is produced through the burning of tobacco.

vaping device
type: Class
subclass of: product
has curation status: Published
definition: A product that produces a vapour for inhalation by a person.
alternative term: vaporizer
definition source: https://en.wikipedia.org/wiki/Vaporizer_(inhalation_device)
comment: This class includes any device that produces vapour or aerosol for inhalation for any purpose. There are many different ways in which the vapour is created and many different substances that are inhaled. It is essential when using this term make clear what type of vaporiser is being referred to and what substance or substances are being inhaled.

alcohol-related mortality
type: Class
subclass of: mortality
has curation status: Proposed
definition: Mortality in a population in which the deaths in question are at least partly caused by the consumption of alcohol by people in that population.
comment: Expressed in terms of number or proportion of deaths or population attributable fraction.

HIV epidemic
type: Class
subclass of: epidemic
has curation status: Proposed
definition: Epidemic of HIV infection.
curator note: No definition found in Ontobee

mortality
type: Class
subclass of: population attribute
has curation status: Proposed
definition: A population attribute that reflects the number of deaths within a population within a time frame.

population health
type: Class
subclass of: population attribute
has curation status: Proposed
definition: The health of a population

quality-adjusted life year
type: Class
subclass of: data item
has curation status: Proposed
definition: A data item that is the estimated number of years that a person can expect to live, adjusted downwards according to how far the assessed quality of life of that person is less than what is judged to be optimal.
alternative term: QALY
curator note: No appropriate ontological definition found. Definition based on https://en.wikipedia.org/wiki/Quality_of_life
comment: The issue of who does the judging would need to be specified and the basis for the judgement.

supply-induced treatment demand
type: Class
subclass of: treatment demand
has curation status: Proposed
definition: Treatment demand that is influenced by the availability of the treatment to to population.

treatment demand
type: Class
subclass of: population attribute
has curation status: Proposed
definition: A quality of a population that involves the number of people in the population who seek a treatment.

12-month diagnosis of alcohol use disorder
type: Class
subclass of: data item
has curation status: Discussed
definition: A data item that is about a person and signifies that the person has been diagnosed with alcohol use disorder within the past 12 months.

abstainer
type: Class
subclass of: human being
has curation status: Proposed
definition: A person who is not engaging in a behaviour pattern that they previously enacted.

access to a service
type: Class
subclass of: personal attribute
has curation status: Proposed
definition: A personal attribute that is the how readily a person can access a service.

acute effect of ingesting a substance on a person
type: Class
subclass of: acute effect of using a product on a person
has curation status: Proposed
definition: Acute effect of using a product on a person in which use of the product involves ingestion of a psychoactive substance.

acute effect of ingesting alcohol on a person
type: Class
subclass of: acute effect of ingesting a substance on a person
has curation status: Proposed
definition: Acute effect of ingesting a substance on a person in which the substance is alcohol.

acute effect of using a product on a person
type: Class
subclass of: process
has curation status: Proposed
definition: A process involving a person that results directly from,and within a short time period of, use by the person of a product.

addiction
type: Class
subclass of: mental disposition
has curation status: Published
definition: A mental disposition towards repeated episodes of abnormally high levels of motivation to engage in a behaviour, acquired as a result of engaging in the behaviour, where the behaviour results in risk or occurrence of serious net harm.
alternative term: Dependence
curator note: The aim is to include dispositions about which there is a consensus that they constitute addiction while avoiding making a disputed statement about whether addiction necessarily involves disordered brain mechanisms (e.g. cases where a person's addiction may be considered an adaptive response to very chellenging life circumstances but may nevertheless benefit from treatment).
comment: This entity focuses on abnormal motivation to engage in a behaviour and includes serious net harm as a feature. The reason is to limit the class to things that merit a treatment and public health response. It is a quantitative entity and a fuzzy set because there can be varying thresholds set for degree of harm and strength of motivation. As a result, it is essential to operationalise the term for it to be meaningful.

adult
type: Class
subclass of: human being
has curation status: Discussed
definition: A person who has reached maturity.
comment: For use in research contexts the minimum age needs to be specified.

alcohol-related death
type: Class
subclass of: death
has curation status: Proposed
definition: Death that is causally influenced by the consumption of alcohol by a person.
curator note: No appropriate definition found. Definition based on usage. a causally influenced b iff a is a process
comment: The consumption of alcohol can be either by the decedent or another person. Includes death from disease and death from injury.

alcohol-related injury
type: Class
subclass of: injury
has curation status: Proposed
definition: Injury that is caused at least in part by the consumption of alcohol by a person.

alcohol-related outcome
type: Class
subclass of: process
has curation status: Proposed
definition: A process that is causally influenced by consumption of alcohol by a person.
curator note: Logically defined class: its members will be inferred by the OWL reasoner - it does not have to be a parent of another class

alcohol-related traffic crash
type: Class
subclass of: traffic accident
has curation status: Proposed
definition: A traffic crash that is at least partially caused by intoxication resulting from consumption of alcohol.

aspect
type: Class
subclass of: occurrent
has curation status: Discussed
definition: A fiat part of a complex phenomenon that has salience in a particular context.

bodily harm
type: Class
subclass of: harm
has curation status: Proposed
definition: Harm that inheres in a person.

cannabis dependence
type: Class
subclass of: substance addiction
has curation status: Proposed
definition: Addiction to use of cannabis or cannabis products.
alternative term: Cannabis addiction
definition source: https://www.ebi.ac.uk/ols/ontologies/ncit/terms

cannabis user
type: Class
subclass of: substance user
has curation status: Proposed
definition: A substance user who uses cannabis.

cardiopulminary absolute risk
type: Class
subclass of: disease absolute risk
has curation status: Proposed
definition: A disposition of a person involving the probability of experiencing cardiovascular disease or pulmonary disease over a defined time period.

subjective cigarette craving
type: Class
subclass of: subjective craving
has curation status: Discussed
definition: Subjective craving in which the target of the craving is cigarette smoking.

codeine poisoning
type: Class
subclass of: poisoning
has curation status: Proposed
definition: Poison that result from ingestion of codeine.

concurrent non-daily dual user
type: Class
subclass of: e-cigarette and cigarette dual user
has curation status: Proposed
definition: A dual product user who is also an e-cigarette user participating in use that is less than daily frequency.
alternative term: Dual user

core identity
type: Class
subclass of: strong identity
has curation status: Published
definition: A strong identity in which what is represented is appraised as enduring.
comment: The parent class is 'strong identity' which captures the idea that the identity is appraised as important. Core identity adds the characteristic 'enduring'. Therefore core identities are appraised as both important and enduring.

daily cigarette smoker
type: Class
subclass of: daily tobacco smoker
has curation status: Discussed
definition: A daily tobacco smoker whose who engages in cigarette smoking every day.
alternative term: Daily smoker

daily tobacco smoker
type: Class
subclass of: tobacco smoker
has curation status: Discussed
definition: A daily tobacco user who engages in tobacco smoking every day.
alternative term: daily cigarette smoker
comment: This class is for tobacco smokers who smoke every day, no matter how many episodes of smoking they have each day. Smokers who smoke on average one or more cigarettes each day but do not smoke every day come under the class non-daily tobacco smoker. Daily tobacco smokers people who may very occasionally miss a day of smoking.

drive state
type: Class
subclass of: subjective affective feeling
has curation status: Proposed
definition: A subjective emotional feeling that generates a need state and arises from deviation of a physiological state from a target state established as a result of innate or learned processes.

dual daily user
type: Class
subclass of: e-cigarette and cigarette dual user
has curation status: Proposed
definition: A dual product user who particpates in use of both e-cigarettes and tobacco cigarettes every day.
alternative term: Dual user

e-cigarette and cigarette dual user
type: Class
subclass of: human being
has curation status: Discussed
definition: A person who engages in e-cigarette use and cigarette smoking.
alternative term: occassional e-cigarette user
comment: This class includes people who currently use both e-cigarettes and cigarettes rather than people who have once used one product and then used another. This creates ambiguity and to what counts as currently and when operationalised it may be helpful to specify the time period over which episodes of use of both products occurred.

e-cigarette user
type: Class
subclass of: human being
has curation status: Discussed
definition: A person who engages in e-cigarette use.

feeling of need satisfaction
type: Class
subclass of: subjective affective feeling
has curation status: Proposed
definition: A subjective emotional feeling involving positive affect associated with reduction in a feeling of need.

wanting to stop cigarette smoking
type: Class
subclass of: subjective want
has curation status: Discussed
definition: A subjective want where the imagined scenario is stopping cigarette smoking indefinitely.

identity
type: Class
subclass of: cognitive representation
has curation status: Published
definition: A cognitive representation of themselves by a person or a group about themselves.
comment: This entity is more than self-identity of an individual as it includes group identity.

injury
type: Class
subclass of: disorder
has curation status: Discussed
definition: A disorder that involves some structural damage that is immediately caused by a destructive external force.
definition source: OGMS:0000102
curator note: Replaced 'catastrophic' with 'destructive'.

nicotine drive state
type: Class
subclass of: drive state
has curation status: Proposed
definition: A drive state that results from nicotine concentrations in the brain that are below that to which the brain has become accustomed.

non-daily tobacco smoker
type: Class
subclass of: tobacco smoker
has curation status: Proposed
definition: A tobacco smoker who participates in tobacco smoking but not every day.
alternative term: Occasional smoker

past 30-day tobacco smoker
type: Class
subclass of: ever tobacco smoker
has curation status: Discussed
definition: An ever-tobacco smoker who has participated in tobacco smoking within the past 30 days.
alternative term: past-20 day smoker
comment: This includes any participation, including one puff on a single cigarette. It is in references to a current time frame that needs to be specified unless it is obvious from the context.

pathological gambling
type: Class
subclass of: addiction
has curation status: Proposed
definition: Addiction to the behaviour of gambling.
alternative term: Gambling use Disorder
definition source: http://purl.obolibrary.org/obo/NCIT_C94335
curator note: Pathological gambling = DSM-IV

person at risk of opioid use disorder
type: Class
subclass of: human being
has curation status: Proposed
definition: A person who does not suffer from opioid use disorder but who, by virtue of his or her personal qualities or environment, has an elevated probability of developing opioid use disorder in the future.

policy maker
type: Class
subclass of: human being
has curation status: Discussed
definition: A person who participates in policy making.

positive tobacco smoker identity
type: Class
equivalent class: Class
  intersection of: tobacco smoker identity
  intersection of: positive self-appraisal
subclass of: tobacco smoker identity
subclass of: positive self-appraisal
has curation status: Published
definition: A tobacco smoker identity that is a positive identity.
alternative term: positive smoker identity

poverty
type: Class
subclass of: personal attribute
has curation status: Proposed
definition: A personal attribute of not having enough material possessions or income to meet basic human needs.
definition source: https://en.wikipedia.org/wiki/Poverty
curator note: Definition changed to one that is ontologically OK.

predominant smoker
type: Class
subclass of: e-cigarette and cigarette dual user
has curation status: Proposed
definition: A dual product user who reports predominanly smoking.
alternative term: Dual user
curator note: A class of 'dual-user'

predominant vaper
type: Class
subclass of: e-cigarette and cigarette dual user
has curation status: Proposed
definition: A dual product user who reports predominanly using an e-cigarette.
alternative term: Dual user

premature death
type: Class
subclass of: death
has curation status: Proposed
definition: Death that occurs as a result of an avoidable set of circumstances.

quality of life
type: Class
subclass of: personal attribute
has curation status: Proposed
definition: A personal attribute that is a person's ability to carry out activities needed to thrive and their mental well-being.
alternative term: QoL
curator note: No appropriate ontological definition found. Definition based on https://en.wikipedia.org/wiki/Quality_of_life
comment: Multiple formulations exist focusing on different aspects. Domains covered include: mental mood, pain, and physical functioning.

self-appraisal
type: Class
subclass of: affective appraisal
has curation status: Published
definition: An appraisal by a person about themselves

self-identity
type: Class
subclass of: identity
has curation status: Published
definition: An identity that a person has about themselves.
curator note: The term 'self' sounds tautologous but is required to reflect the fact that this is not identity in terms of who you are but how you represent yourself to yourself.
comment: The cognitive representation includes multiple aspects and some of these are social. For example, group memberships, cultural norms. Collective identity as a shared attribute of group is related to this but is separate.

subjective sensation
type: Class
subclass of: subjective affective feeling
has curation status: Proposed
definition: A subjective emotional feeling involving experience directly resulting from sensory processes. It includes touch, brightness, loudness.

targeted emotion
type: Class
subclass of: emotion process
has curation status: Proposed
definition: An emotion directly attributing an affective response to an object, event or experience. It includes liking and disliking.

tobacco-caused disease
type: Class
subclass of: disease
example of usage: Use of combustible tobacco is a leading cause of tobacco-related disease.
has curation status: Discussed
definition: A disease in which tobacco use has played a causal role.

tobacco-related disease
type: Class
subclass of: disease
example of usage: Use of combustible tobacco increases the users risk of developing tobacco-related disease.
has curation status: Discussed
definition: A disease in which tobacco use is a significant risk factor.

tobacco smoker
type: Class
subclass of: tobacco user
has curation status: Discussed
definition: A tobacco user who engages in tobacco smoking.
alternative term: current tobacco smoker
curator note: 'tobacco user' and 'participates in' some 'tobacco smoking'
comment: This applies to the current time period and the behaviour pattern of tobacco smoking. The time period and the amount of smoking needs to be operationalised.

tobacco smoker identity
type: Class
subclass of: self-identity
has curation status: Published
definition: A self-identity in which a person represents themselves as a tobacco smoker.

urge
type: Class
subclass of: mental process
has curation status: Proposed
definition: A mental process that involves a feeling of strong impulse to engage in a behaviour.

urge to smoke
type: Class
subclass of: urge
has curation status: Proposed
definition: An urge in which the behaviour that is the target of the feeling is smoking.

vaper identity
type: Class
subclass of: self-identity
has curation status: Published
definition: An identity in which a person represents themselves as a vaper.

young person
type: Class
subclass of: human being
has curation status: Discussed
definition: A person whose age is less than that of an adult.
comment: This class is different from 'youth' and is intended to cover any person from birth up to adulthood. It includes, infant, child, and adolescent.

alcohol industry
type: Class
subclass of: industry
has curation status: Discussed
definition: An industry that is realised in the manufacture and sale of alcoholic beverages.

cannabis industry
type: Class
subclass of: industry
has curation status: Proposed
definition: An industry that is realised in the manufacture and sale of cannabis.

vaping device company
type: Class
subclass of: commercial organisation
has curation status: Proposed
definition: A commercial organisation that is engaged in the manufacture, preparation for sale, shipment, advertisement, or distribution of a vaping device or part of such a product, or is at least partly owned by such an organisation.

e-cigarette industry
type: Class
subclass of: industry
has curation status: Discussed
definition: An industry that is realised in the manufacture and sale of e-cigarettes, e-cigarette components and e-liquid.
alternative term: E-Cig industry
curator note: I have added here promotion of - this sets industry apart from manufactureres of but also includes these types of company.

gambling industry
type: Class
subclass of: industry
has curation status: Proposed
definition: An industry that is realised in the processes of facilitating and managing the wagering of money or valuables.

industry
type: Class
subclass of: realizable
has curation status: Discussed
definition: A realizable entity that inheres in a collection of organisations, people, equipment and resources and is realised in processes of production, distribution or service provision, and is characterised by a common purpose or set of related economic activities.
definition source: claude.ai

marketing
type: Class
subclass of: process
has curation status: Discussed
definition: A process undertaken by an organisation with the aim of increasing use of a product or service.

retailer
type: Class
subclass of: organisation
has curation status: Proposed
definition: An organisation that sells some product directly to users of that product.

tobacco industry
type: Class
subclass of: industry
has curation status: Proposed
definition: An industry that is realised in the manufacture or sale of tobacco and tobacco-containing products.

vape shop
type: Class
subclass of: shop
has curation status: Discussed
definition: A shop that primarily sells products related to vaping devices.

academic emergency department facility
type: Class
subclass of: emergency department facility
has curation status: Discussed
definition: An emergency department facility that is part of a university hospital.

accessibility of a product
type: Class
subclass of: environmental disposition
has curation status: Discussed
definition: An environmental disposition that is the extent to which an environment enables people in that environment to acquire a product.

accessibility of a service
type: Class
subclass of: environmental disposition
has curation status: Discussed
definition: An environmental disposition that is the extent to which an environment enables people in that environment to receive a service.

accessibility of heroin
type: Class
subclass of: accessibility of a product
has curation status: Discussed
definition: Accessibility of a product where the product is heroin.

accessibility of opioid agonist therapy
type: Class
subclass of: accessibility of addiction treatment
has curation status: Discussed
definition: Accessibility of a service where the service is opioid agonist therapy

acute medical unit
type: Class
subclass of: health care facility
has curation status: Discussed
definition: A health care facility within a hospital that provides acute medical care for patients that have presented as medical emergencies to a hospital or who have developed an acute medical illness while in hospital.
alternative term: acute medical ward
definition source: https://www.rcpmedicalcare.org.uk/designing-services/specialties/acute-internal-medicine/services-delivered/acute-medical-unit/

accessibility of alcohol
type: Class
subclass of: accessibility of a product
has curation status: Discussed
definition: Accessibility of a product where the product is an alcoholic beverage
alternative term: alcohol availability

level of economic development
type: Class
subclass of: data item
has curation status: Discussed
definition: A data item that is about the amount and quality of human and physical resources available to the inhabitants of a geospatial region.
definition source: https://en.wikipedia.org/wiki/Economic_development

nicotine dose
type: Class
subclass of: dose
has curation status: Proposed
definition: Dose in which the thing administered is nicotine.

policy
type: Class
subclass of: action specification
has curation status: To Be Discussed
definition: An action specification of a person or organisation that is realised as a set of rules and activities affecting people or organisations under its jurisdiction.

prior product authorisation law
type: Class
subclass of: law
has curation status: Proposed
definition: A law that creates a requirement on product manufacturers to pre-notify a relevant authority of the product characteristics and receive approval before marketing a product.

naloxone pharmacy access law
type: Class
subclass of: pharmacy access law
has curation status: Proposed
definition: A pharmacy access law in which the product being distributed is naloxone.

pharmacy access law
type: Class
subclass of: law
has curation status: Proposed
definition: A law that aims to facilitate distribution of a product through retail pharmacy channels.

tobacco control policy
type: Class
subclass of: government policy
has curation status: Discussed
definition: A government policy aimed at reducing harm from tobacco use.

addiction treatment
type: Class
subclass of: treatment
has curation status: Proposed
definition: Treatment in which the disorder that is being treated is addiction.

alcohol control policy
type: Class
subclass of: government policy
has curation status: Proposed
definition: A government policy aimed at reducing consumption of alcohol or harm from consumption of alcohol in a population under its jurisdiction.
curator note: No appropriate definition found. Definition based on usage. A disjunctive class.

alcohol harm reduction policy
type: Class
subclass of: alcohol control policy
has curation status: Proposed
definition: An alcohol control policy aimed at reducing the harm from consumption of alcohol in a population under its jurisdication without promoting complete abstinence from alcohol.
curator note: No appropriate definition found. Definition based on usage.

alcohol reduction policy
type: Class
subclass of: alcohol control policy
has curation status: Proposed
definition: An alcohol control policy aimed at reducing the consumption of alcohol in a population under its jurisdiction.
curator note: No appropriate definition found. Definition based on usage.

codeine scheduling
type: Class
subclass of: drug scheduling
has curation status: Proposed
definition: Drug scheduling in which the drug concerned is codeine.

compulsory addiction treatment
type: Class
subclass of: addiction treatment
has curation status: Proposed
definition: Treatment of addiction that either a drug user or a person with a drug problem is compelled to undergo by a legal authority in the jurisdiction in which they reside.

cost per quality-adjusted life-year gained
type: Class
subclass of: data item
has curation status: Proposed
definition: A data item that is about an intervention and is the estimated financial cost of delivering that intervention to a population in a setting in order to gain one QALY in the population.
curator note: No ontological definition found. Definition based on definition of ICER https://en.wikipedia.org/wiki/Incremental_cost-effectiveness_ratio

drink driving legislation
type: Class
subclass of: public policy
has curation status: Proposed
definition: A public policy that involves legislation to reduce the incidence of vehicle driving with alcohol in the body.

drug scheduling
type: Class
subclass of: national drug policy
has curation status: Proposed
definition: A national drug policy that classifies drugs into classes, called 'schedules' according to their (1) potential for abuse, (2) safety, (3) addictive potential and (4) whether or not they have legitimate medical applications. Each schedule has rules regarding restrictions on use and penalties for misuse.
definition source: https://www.healthychildren.org/English/ages-stages/teen/substance-abuse/Pages/Controlled-Substances-Not-Just-Street-Drugs.aspx

e-cigarette policy
type: Class
subclass of: public policy
has curation status: Discussed
definition: A public policy that regulates e-cigarettes, their marketing or their use.
comment: Includes public policies concerning the manufacture, marketing, and sales of e-cigarettes.

intervention scale-up strategy
type: Class
subclass of: plan specification
has curation status: Proposed
definition: A plan specification for delivering an intervention that has been developed on a part of a population to the full population.

legislation
type: Class
subclass of: directive information entity
has curation status: Proposed
definition: A directive information entity that is produced by government and enables, prohibits or bans activities, or establishes rights or responsibilities.

national drug policy
type: Class
subclass of: government policy
has curation status: Proposed
definition: A national policy that concerns the manufacture, marketing, distribution, use and harms from psychoactive drugs.

opioid agonist treatment
type: Class
subclass of: treatment
has curation status: Proposed
definition: A treatment that involves providing a safer opioid agonist to a person with opioid addiction in order to reduce their psychological need for the opioid to which they are addicted.
alternative term: Opioid agonist therapy
curator note: No ontological definition found.

opioid agonist treatment scale-up strategy
type: Class
subclass of: intervention scale-up strategy
has curation status: Proposed
definition: An intervention scale-up strategy for delivering a opioid agonist treatment programme to a population.

government policy
type: Class
subclass of: policy
has curation status: Proposed
definition: An action specification that a government produces that includes rules and regulations concerning activities of agents under the government's jurisdiction.
alternative term: Public policy

subjective craving
type: Class
subclass of: subjective affective feeling
has curation status: Discussed
definition: A subjective affective feeling that is a strong feeling of desire or a strong feeling of urge.

disease absolute risk
type: Class
subclass of: disposition
has curation status: Proposed
definition: A disposition of a person involving the probability of experiencing a given disease over a defined time period.

poisoning
type: Class
subclass of: disorder
has curation status: Proposed
definition: Injury to the body or interference of normal body functions by a substance that is ingested.

substance addiction
type: Class
subclass of: addiction
has curation status: Discussed
definition: An addiction that is to a substance that is ingested.

traffic accident
type: Class
subclass of: process
has curation status: Proposed
definition: A process in which a vehicle collides with an object, person or vehicle, causing damage.

adolescent
type: Class
subclass of: human being
has curation status: Proposed
definition: A person who is undergoing the developmental stage of transition from childhood to adulthood.

law
type: Class
subclass of: rule
has curation status: Proposed
definition: A rule that is enacted by the legal system of a country or geographic region.

addictiveness
type: Class
subclass of: disposition
has curation status: Published
definition: A disposition of a material entity or a process to cause addiction to it.
comment: This is a quantitative entity that is only meaningful when operationalised in terms of the proportion of people who are exposed who become addicted, the mode of use, the severity of addiction and any other contextual factors that may be in play. Addictiveness can be a disposition of material entity such as a chemical substance or a process such as gambling behaviour.

antidepressant drug
type: Class
subclass of: psychoactive substance
has curation status: Discussed
definition: A psychoactive substance that is used to reduce depression.
curator note: Parent in CheBI is psychotropic drug

antimanic drug
type: Class
subclass of: psychoactive substance
has curation status: Discussed
definition: A psychoactive substance that is used to treat mania.

anxiolytic drug
type: Class
subclass of: psychoactive substance
has curation status: Discussed
definition: A psychoactive substance that is used to reduce anxiety.
comment: Note - these drugs are used to reduce anxiety even when there is no anxiety disorder, e.g. associated with worrying events

drug concentration
type: Class
subclass of: concentration
has curation status: Published
definition: The concentration of a drug in a portion of matter.

drug potency
type: Class
subclass of: drug quality
has curation status: Published
definition: A quality of a drug that is the amount of a desired effect of the drug for a given dose and a given mode of administration.
comment: Drugs may have different potencies for different drug effects. Effect of the drug on side-effects is not covered by this definition. If a drug has more than one effect that may be desired, it is necessary to specify what effect or effects are included in a given usage of the term.

drug unit dose
type: Class
subclass of: information content entity
has curation status: Published
definition: An information content entity that specifies the amount of a drug in a single item of a drug preparation.
comment: This is not the same as dose received or dose that is potentially delivered by the preparation into the body. Drug unit dose as an attribute of a defined drug preparation (e.g. as in 4mg nicotine gum, 500mg paracetamol capsule)

liquid commodity
type: Class
subclass of: commodity
has curation status: Published
definition: A commodity that is liquid

mint flavoured e-liquid
type: Class
subclass of: flavoured e-liquid
has curation status: Published
definition: A flavoured e-liquid in which the e-liquid flavouring is designed to have a mint flavour.

menthol flavoured e-liquid
type: Class
subclass of: flavoured e-liquid
has curation status: Published
definition: A flavoured e-liquid in which the e-liquid flavouring is designed to have a menthol flavour.

sweet flavoured e-liquid
type: Class
subclass of: flavoured e-liquid
example of usage: 13% of e-cigarette users report having tried a sweet flavoured e-liquid, e.g., candy floss.
has curation status: Published
definition: A flavoured e-liquid in which the e-liquid flavouring is designed to have a sweet flavour.
comment: Sweet flavours include a broad range of flavour choices but they are distinct from fruit flavours and therefore need to described.

absolute smoking reduction
type: Class
subclass of: data item
has curation status: Proposed
definition: A data item which indicates the absolute reduction number of cigarettes smoked over a period of time.
alternative term: Cigarette reduction
curator note: ADDICTO:0000103

reduction in cigarettes per day
type: Class
subclass of: data item
has curation status: Proposed
definition: A data item which indicates the number of number of cigarettes less per day a person has smoked since the last time data was collected.
alternative term: Cigarettes per day

cigarette demand
type: Class
subclass of: product demand
has curation status: Proposed
definition: A product demand in which the product is cigarettes.
alternative term: Purchase demand

product demand
type: Class
subclass of: population attribute
has curation status: Proposed
definition: A population attribute that involves the amount of a product that a population uses.
comment: It would normally be necessary to specify the population, the product and the conditions that create the demand.

ever use
type: Class
subclass of: behaviour pattern
has curation status: Proposed
definition: A behaviour pattern that includes use of a product at least once.

puff on a cigarette
type: Class
subclass of: cigarette smoking behaviour
has curation status: Proposed
definition: A cigarette smoking behaviour that involves sucking smoke through the cylinder of a cigarette into the mouth via the other end.

number of cigarettes since target quit data
type: Class
subclass of: data item
has curation status: Proposed
definition: A data item which indicates the number of cigarettes smoked by a person since their target quit date.

daily cannabis use
type: Class
subclass of: cannabis use behaviour pattern
has curation status: Proposed
definition: A cannabis use behaviour pattern that involves ingesting cannabis at least once per day.

daily heroin injecting
type: Class
subclass of: heroin use behaviour pattern
has curation status: Proposed
definition: A heroin use behaviour pattern that involves injecting heroin into the body at least once per day.

daily number of puffs on a cigarette
type: Class
subclass of: data item
has curation status: Proposed
definition: A data item which indicates the number of puffs taken per day by a person on a cigarette.
alternative term: Puffs per day

prescription opioid use behaviour pattern
type: Class
subclass of: opioid use behaviour pattern
has curation status: Proposed
definition: An opioid use behaviour pattern that involves using prescription opioids.

dual substance use behaviour
type: Class
subclass of: substance use behaviour pattern
has curation status: Proposed
definition: A substance use behaviour pattern of behaviour that involves the use by a person of two or more psychoactive substances.

dual e-cigarette use duration
type: Class
subclass of: behaviour attribute
has curation status: Proposed
definition: A temporal region during which a person concurrently used both e-cigarettes and cigarettes.
alternative term: Dual use

dual use of e-cigarettes and cigarettes
type: Class
subclass of: consumption behaviour pattern
has curation status: Proposed
definition: A consumption behaviour pattern that involves concurrent use by a person of e-cigarettes and cigarettes.
alternative term: Dual use

duration of behaviour
type: Class
subclass of: temporal region
has curation status: Proposed
definition: The temporal extent that a behavioural process projects into.

e-cigarette demand
type: Class
subclass of: product demand
has curation status: Proposed
definition: A product demand in which the product is e-cigarettes.
alternative term: Purchase demand

heated tobacco containing product demand
type: Class
subclass of: product demand
has curation status: Proposed
definition: A product demand in which the product is heated tobacco containing products.
alternative term: Purchase demand
comment: The type of heated tobacco containing product should also be defined.

number of cigarettes smoked per day
type: Class
subclass of: data item
has curation status: Discussed
definition: A data item which is about the amount of cigarette smoking a person does and is the average number of cigarettes smoked per day by a person over a period.
alternative term: Cigarettes/day

number of drinks consumed
type: Class
subclass of: data item
has curation status: Proposed
definition: A data item which indicates the number of alcoholic drinks consumed within a defined period.

number of drinks per drinking day
type: Class
subclass of: data item
has curation status: Proposed
definition: A data item which indicates the number of alcoholic drinks consumed per day.

number of e-cigarette puffs per day
type: Class
subclass of: data item
has curation status: Proposed
definition: A data item which indicates the number of puffs taken per day by a person on a e-cigarette.

number of years of cigarette smoking
type: Class
subclass of: data item
has curation status: Proposed
definition: A data item which indicates the number of years a person has been smoking cigarettes.
alternative term: Years of smoking
comment: Number of years smoking does not provide any indication of amount or frequency of smoking.

pack years
type: Class
subclass of: data item
has curation status: Proposed
definition: A number denoting a quantity of cigarette smoking made up of the number of years of smoking multiplied by the number packs of 20 cigarettes smoked on average per day over that period.

packs of cigarettes smoked per day
type: Class
subclass of: data item
has curation status: Proposed
definition: A data item which is about the amount of cigarette smoking that a person does and is the number of packs of cigarettes smoked by a person per day.

point prevalence tobacco smoking abstinence
type: Class
subclass of: tobacco smoking abstinence
has curation status: Proposed
definition: Tobacco smoking abstinence for a short period of time leading up to a point of assessment.
comment: The period of time over which the person is abstinent needs to be specified. Is is usually 7 days.

smokeless tobacco use
type: Class
subclass of: tobacco use behaviour
has curation status: Discussed
definition: Tobacco use behaviour that involves the use of a smokeless tobacco-containing product.
alternative term: non-combustible tobacco use

smokeless tobacco demand
type: Class
subclass of: product demand
has curation status: Proposed
definition: A product demand in which the product is smokeless tobacco.
alternative term: Purchase demand
comment: The type of smokeless tobacco product should also be defined.

former tobacco smoker
type: Class
subclass of: human being
has curation status: Discussed
definition: A person who was a tobacco smoker in the past but who is not currently a tobacco smoker.
alternative term: ex-smoker, ex-tobacco smoker
definition source: CN
comment: This class aims to capture as objectively as possible the history of a person's behaviour. It does not make reference to whether the person considers themselves be an ex-smoker because this is captured by the 'ex-tobacco smoker identity' class.

ex-tobacco smoker identity
type: Class
subclass of: self-identity
has curation status: Published
definition: A self-identity in which a person represents themselves as having previously been a tobacco smoker but currently not being a tobacco smoker.
definition source: CN

group identity
type: Class
subclass of: identity
has curation status: Published
definition: An identity that a group holds about itself.
curator note: can a socially shared representtaion be said to be purely cognitive? I.e query parent entity?

lost self-identity
type: Class
subclass of: self-identity
has curation status: Published
definition: A self-identity in which a person represents themselves as no longer having some positively appraised characteristic.

non tobacco smoker identity
type: Class
subclass of: self-identity
has curation status: Published
definition: A self-identity in which a person represents themselves as a not being a tobacco smoker.

spoiled self-identity
type: Class
subclass of: self-identity
has curation status: Published
definition: A self-identity representing something as having been positively appraised in the past but as currently negatively appraised.

behaviour attribute
type: Class
subclass of: process
has curation status: Proposed
definition: An element of a behaviour process which can be used to characterise the behaviour
curator note: Should this be defined in the Human Behaviour Ontology?

age of nicotine product first use
type: Class
subclass of: data item
has curation status: Proposed
definition: A data item that is about the age at which a nicotine product was first used.

number of days abstinent
type: Class
subclass of: data item
has curation status: Proposed
definition: A data item which indicates the number of days a person has remained abstinent from a particular substance or behaviour.

number of days per week of excessive drinking
type: Class
subclass of: data item
has curation status: Proposed
definition: A data item which indicates the number of days per week a person has drunk alcohol to levels which are considered to be excessive.
comment: The writer must state by which organisations value or measure the person is considered to be drinking excessively.

number of days required to achieve abstinence
type: Class
subclass of: data item
has curation status: Proposed
definition: A data item which indicates the number of days required to achieve abstinence from alcohol.

number of drinking days per week
type: Class
subclass of: data item
has curation status: Proposed
definition: A data item which indicates the number of alcoholic drinks consumed per week.

solitary drinking
type: Class
subclass of: alcohol consumption
example of usage: "Solitary drinking was defined as drinking while physically alone ". Skrzynski CJ, Creswell KG. A systematic review and meta-analysis on solitary drinking in adults.
has curation status: Proposed
definition: Alcohol consumption in which the person consuming an alcohol-containing product does so with no-one else present in the same location.
curator note: This definition has been chosen because it is the most commonly encountered term in the research literature.
comment: The definition would not count as solitary drinking alcohol consutmpsion in which there was someone present but not consuming alcohol

pharmaceutical disposition to adverse reaction
type: Class
subclass of: pharmaceutical disposition
has curation status: Discussed
definition: A disposition of a pharmaceutical to cause some clinical symptom or medical condition when taken into the body.

alcohol beverage retailer
type: Class
subclass of: retailer
has curation status: Discussed
definition: A retailer that sells alcohol beverages.

beverage
type: Class
subclass of: liquid commodity
has curation status: Discussed
definition: A liquid commodity that is designed to be consumed by people.

blunt
type: Class
subclass of: combustible tobacco-containing product
subclass of: Restriction
  on property: has part
  some values from: cannabis
has curation status: Published
definition: A combustible tobacco-containing product that is a cylinder of tobacco leaf containing cannabis.
definition source: https://en.wikipedia.org/wiki/Blunt_(cannabis)
comment: In some cases a cigar is hollowed out and filled with cannabis. Blunts can also be manufactured.

brand diversity
type: Class
subclass of: information content entity
has curation status: Discussed
definition: An information content entity that is about the use of multiple brands for the same product in order to increase the market for that product.

buprenorphine-naloxone
type: Class
subclass of: pharmaceutical
subclass of: Restriction
  on property: has role
  some values from: opioid analgesic
has curation status: Discussed
definition: A pharmaceutical that contains buprenorphine mixture and naloxone.
alternative term: (BP-NLX)

cannabinoid pharmaceutical
type: Class
subclass of: pharmaceutical
subclass of: Restriction
  on property: has part
  some values from: cannabinoid
has curation status: Discussed
definition: A pharmaceutical that contains some cannabinoid.

cigarillo
type: Class
subclass of: cigar
has curation status: Published
definition: A cigar that is short and thin with wrapping that is tobacco or tobacco-based paper.
definition source: https://en.wikipedia.org/wiki/Cigarillo
comment: Cigarillos are widely used in the same way as cigarettes, with the smoke being inhaled into the lungs. For public health purposes they should be classed with cigarettes.

coffee
type: Class
subclass of: commodity
has curation status: Discussed
definition: A commodity that is ground, roasted coffee beans.
comment: This entity is the ground coffee. For the coffee drink see 'coffee beverage'.

weekly cost of e-cigarette use
type: Class
subclass of: data item
subclass of: Restriction
  on property: is about
  some values from: e-cigarette use
has curation status: Discussed
definition: A data item which is about the amount of money spent per week on e-cigarettes.
comment: Cost relates to currency and period of time, both must be defined.

fentanyl-adulterated drug preparation
type: Class
subclass of: pharmaceutical
has curation status: Discussed
definition: A pharmaceutical that has fentanyl in it without that being notified to the user.

financial cost of a product or service
type: Class
subclass of: data item
has curation status: Discussed
definition: A data item that is about the amount of money that has to be paid to purchase a product or service
alternative term: cost
comment: Indicate currency and period of time, both must be defined.

weekly financial cost of cigarette smoking
type: Class
subclass of: data item
has curation status: Discussed
definition: A data item that is about the amount of money a person who smokes cigarettes spends on cigarettes.
comment: This includes own-roll cigarettes but not cigars.

medicine
type: Class
subclass of: product
has curation status: Proposed
definition: A product that has a marketing license from the medicines regulatory authority of a jurisdiction to prevent, manage or treat a condition.

menthol cigarette
type: Class
subclass of: cigarette
has curation status: Proposed
definition: A cigaratte that is flavoured with the compound menthol.

narcotic
type: Class
subclass of: psychoactive substance
has curation status: Proposed
definition: A psychoactive substance which is consumed for non-medical purposes and usually sold illegally.

novel psychoactive substance
type: Class
subclass of: psychoactive substance
has curation status: Proposed
definition: A psychoactive substance that is newly recognised as a drug of abuse.
alternative term: emerging drug

new synthetic cannabinoid receptor agonist
type: Class
subclass of: synthetic cannabinoid receptor agonist
has curation status: Proposed
definition: A synthetic cannabinoid receptor agonist that is novel and new in its usage.
alternative term: SCRA

opiate
type: Class
subclass of: opioid analgesic
has curation status: Proposed
definition: An opioid that is a naturally occuring psychoactive substance derived from the plant papaver somniferum

oral naltrexone
type: Class
subclass of: naltrexone
has curation status: Proposed
definition: Naltrexone that is consumed via the mouth.

orally administered
type: Class
subclass of: role
has curation status: Proposed
definition: A role preformed by an individual who participates in administering a substance orally.

psychostimulant
type: Class
subclass of: psychoactive substance
has curation status: Proposed
definition: A psychoactive substance that stimulates the central nervous system.
alternative term: stimulants

sedative drug
type: Class
subclass of: central nervous system depressant
has curation status: Proposed
definition: A central nervous system depressant that has the application of sedative effects.

synthetic cannabinoid receptor agonist
type: Class
subclass of: cannabinoid receptor agonist
has curation status: Proposed
definition: A cannabinoid receptor agonist which consists of synthetic analogs of the naturally occurring cannabinoids.

systemic bioavailability
type: Class
subclass of: data item
has curation status: Proposed
definition: The extent and rate at which a substance is absorbed in order to have a physiological affect on the whole body.

person with alcohol use disorder
type: Class
subclass of: alcohol user
has curation status: Proposed
definition: An alcohol user who presents with alcohol use disorder.
alternative term: harmful drinker
comment: We strongly advise against using synonyms and especially alcoholic, this term given its lack of clinical definition and stigmatising connotations.

alcohol user
type: Class
subclass of: substance user
has curation status: Discussed
definition: A psychoactive substance user who consumes alcohol.
alternative term: alcohol consumer

chain smoker
type: Class
subclass of: daily cigarette smoker
has curation status: To Be Discussed
definition: A daily cigarette smoker who, when circumstances allow, smokes continually with little or no tempora gap between cigarettes for much of their waking hours.
alternative term: Heavy smoker

ever tobacco smoker
type: Class
subclass of: tobacco smoker
has curation status: Proposed
definition: A tobacco smoker who has ever participated in smoking.
alternative term: Ever smoker
comment: Ever should be further defined and frequency of past use should be indicated where possible.

tobacco smoker and ex-e-cigarette user
type: Class
subclass of: tobacco smoker
has curation status: Discussed
definition: A tobacco smoker who is an ex-e-cigarette user
alternative term: ex-vaper
comment: This class requires specification of the time period since e-cigarette use stopped. E-cigarette use may have been with or without tobacco smoking.

ex-smoking e-cigarette user
type: Class
subclass of: e-cigarette user
has curation status: Discussed
definition: An e-cigarette user who is a former tobacco smoker.

former regular tobacco smoker
type: Class
subclass of: former tobacco smoker
has curation status: Discussed
definition: A person who was a regular tobacco smoker in the past but is not currently a tobacco smoker.
comment: The use of 'regular tobacco user' in this case does not mean daily or weekly but rather that the person has used tobacco for at least a year.

former substance user
type: Class
subclass of: human being
has curation status: Discussed
definition: A person who was a substance in the past but is not currently a substance user.
alternative term: ex-substance user
comment: Substance use includes caffeine, nicotine, alcohol as well as ones that are generally referred to in the literature such as cannabis.

former cigarette smoker
type: Class
subclass of: human being
has curation status: Discussed
definition: A person who was a cigarette smoker in the past but is not currently a cigarette smoker.
alternative term: ex-smoker, ex-cigarette smoker
curator note: Note that the parent cannot be former tobacco smoker because a former cigarette smoker may still be using another form of tobacco

person who injects drugs
type: Class
subclass of: substance user
has curation status: Discussed
definition: A substance user whose use involves injection of some psychoactive substance.
alternative term: Injecting drug user

never tobacco smoker
type: Class
subclass of: human being
has curation status: Proposed
definition: A person who has never smoked tobacco.
comment: Never smoker is often defined as a person who has smoked fewer than 20 cigarettes (including roll ups and cannabis joints) in their lifetime.

not a current smoker
type: Class
subclass of: human being
has curation status: Proposed
definition: A person who does not currently report smoking tobacco.
alternative term: non-smoker
comment: The term nono-smoker is included as a synonym but is discouraged from use. Not currently smoking also needs to be further defined by providign details of time since last smoking and frequency of smoking.

non-substance user
type: Class
subclass of: human being
has curation status: Discussed
definition: A person who is not a substance user.
alternative term: non-psychoactive substance user

past-year tobacco smoker
type: Class
subclass of: ever tobacco smoker
example of usage: An example using this definition: https://onlinelibrary.wiley.com/doi/full/10.1111/add.15295
has curation status: Discussed
definition: An ever-tobacco smoker who has participated in tobacco smoking within the past year.
alternative term: past-year smoker
comment: This definition is commonly used in outputs from the Smoking Toolkit Study. It refers to those who affirm smoking any tobacco products within the past 12 months. For more info see: www.smokinginengland.info

person with opioid use disorder
type: Class
subclass of: opioid user
has curation status: Proposed
definition: An opioid user who presents with a clinical diagnosis of opioid use disorder.
alternative term: drug user substance user

pregnant smoker
type: Class
subclass of: tobacco smoker
has curation status: Proposed
definition: A tobacco smoker that is pregnant.

recent former regular tobacco smoker
type: Class
subclass of: former regular tobacco smoker
has curation status: Discussed
definition: A former regular tobacco smoker who has smoked within the past 12 months.
alternative term: past regular smoker

recent smoker
type: Class
subclass of: tobacco smoker
has curation status: Proposed
definition: A tobacco smoker who reports recently smoking.
alternative term: recent smoker
comment: The time period that is meant by recent must be defined.

group 1 carcinogen
type: Class
subclass of: carcinogen
has curation status: Discussed
definition: A carcinogen where there is sufficent evidence, with an established casual relationship, to suggest it is carcinogenic to humans.
definition source: IARC

group 2 carcinogen
type: Class
subclass of: carcinogen
has curation status: Discussed
definition: A carcinogen where there is limited evidence in humans, but sufficient evidence in animals to suggest it is probably carcinogenic to humans.
definition source: IARC

crack cocaine
type: Class
subclass of: cocaine
has curation status: Discussed
definition: Cocaine that has been heated, purified, concentrated, and compressed into smokeable, pebble-sized crystals.
definition source: UMLS Metathesaurus Browser (nih.gov)

toxin
type: Class
subclass of: substance
has curation status: Proposed
definition: A substance that is produced by a living organsism and is toxic, noxious or poisonous
definition source: UMLS Metathesaurus Browser (nih.gov)

carcinogen
type: Class
subclass of: chemical substance
subclass of: Restriction
  on property: has role
  some values from: carcinogenic agent
has curation status: Published
definition: A chemical substance that has the carcinogenic agent role.
comment: This is distinguished from carcinogenic agent in order to separate a chemical from its role. Carcinogenic agent role is defined in CHEBI as 'A role played by a chemical compound which is known to induce a process of carcinogenesis by corrupting normal cellular pathways, leading to the acquisition of tumoral capabilities.'

risk of relapse to tobacco use
type: Class
subclass of: bodily disposition
has curation status: Discussed
definition: A bodily disposition which is the degree to which the person is at risk of relapse to tobacco use.

age of smoking cessation
type: Class
subclass of: human age
has curation status: Proposed
definition: The age at which a person reports quitting smoking tobacco.
alternative term: Age quit smoking

cannabis smoker
type: Class
subclass of: cannabis user
has curation status: Proposed
definition: A cannabis user who smokes cannabis.
comment: This defintion deliberately seperates cannabis smoking from the use of cannabis by edibles.

cannabis vaper
type: Class
subclass of: cannabis user
has curation status: Proposed
definition: A cannabis user who vapes cannabis.
comment: This defintion deliberately seperates cannabis smoking from vaping.

daily cannabis smoker
type: Class
subclass of: cannabis user
has curation status: Proposed
definition: A daily cannabis user who smokers cannabis daily.

daily cannabis user
type: Class
subclass of: cannabis user
has curation status: Proposed
definition: A cannabis user who uses cannabis products daily.

daily e-cigarette user
type: Class
subclass of: e-cigarette user
has curation status: Discussed
definition: An e-cigarette user who engages in e-cigarette use every day.
alternative term: daily vaper
comment: if not daily e-cigarette user.
comment: If other products are used alongside the e-cigarette this should be noted

daily non-treatment-seeking cigarette smoker
type: Class
subclass of: daily cigarette smoker
has curation status: Proposed
definition: A daily cigarette smoker who is not seeking smoking cessation treatment.
alternative term: daily tobacco user

dependent cigarette smoker
type: Class
subclass of: tobacco smoker
has curation status: Proposed
definition: A cigarette smoker who is tobacco dependent according to a defined and validated measure.
alternative term: nicotine dependent
comment: The measure and data must be presented.

e-cigarette first user
type: Class
subclass of: e-cigarette user
has curation status: Proposed
definition: An e-cigarette user who self-reports first time ever use of an e-cigarette.
alternative term: New e-cigarette user
comment: The purpose of this defintion is only to highlight first use. In addition to this it is important to state whether the person using the e-cigarette is a current smoker, ex-smoker or never.

exclusive cannabis smoker
type: Class
subclass of: cannabis smoker
has curation status: Proposed
definition: A cannabis smoker who only smokes their cannabis.
alternative term: cannabis smoker
comment: Intended defintion for those who smoke their cannabis only and do not use cannabis in any other form.

exclusive cannabis vaper
type: Class
subclass of: cannabis vaper
has curation status: Proposed
definition: A cannabis vaper who only vapes their cannabis.
alternative term: cannabis vaper
comment: This defintion is for those who chose to vape their cannabis and are not using their cannabis in any form which involves combustion.

non-tobacco using e-cigarette user
type: Class
subclass of: e-cigarette user
has curation status: Discussed
definition: An e-cigarette user who is not a tobacco user.
alternative term: daily e-cigarette user
comment: Exclusive user refers to the complete absence of a tobacco containing product. They could be using another kind of nicotine product such as nicotine transdermal patch.

long-term ex-smoker
type: Class
subclass of: former tobacco smoker
has curation status: Proposed
definition: An ex-smoker who has not smoked for approximately one-year or more.
alternative term: ex-smoker
comment: This is fuzzy set because the time frame is approximate and needs to be defined in published work.

non-daily e-cigarette user
type: Class
subclass of: e-cigarette user
has curation status: Proposed
definition: An e-cigarette user who does not use their e-cigarette on a daily basis.
alternative term: non daily vaper
comment: The frequency of use should still be quatified if possible and other products e.g., cigarettes, if used alongside should be recorded.

non-treatment seeking substance user
type: Class
subclass of: substance user
has curation status: Discussed
definition: A substance user who is not seeking treatment for their substance use at the current time of recording data.

user of edible cannabis products
type: Class
subclass of: cannabis user
has curation status: Proposed
definition: A cannabis user who ingests cannabis through edible products.
comment: This defintion deliberately seperates cannabis smoking from the use of cannabis by edibles.

cannabis vape pen
type: Class
subclass of: cannabis vaping device
has curation status: Discussed
definition: A cannabis vaping device that is shaped like a pen and consists of a battery, a container for cannabis or a cannabis extract, an atomiser to create cannabis vapour, and a mouthpiece.
alternative term: dab pen (US)

developmental toxicant
type: Class
subclass of: toxicant
has curation status: Discussed
definition: A toxicant that has impairs the developmental process of an organism.

alcohol toxicity
type: Class
subclass of: toxicity of a substance
has curation status: Discussed
definition: Toxicity of a substance in which the substance is ethanol.

dry herb vaporiser pen
type: Class
subclass of: dry herb vaporiser
has curation status: Discussed
definition: A dry herb vaporiser that is shaped like a pen and is portable.
alternative term: dry herb pen, dry herb tank, dry herb (or weed) atomizer
comment: Clarify what type of cannabis is being vaped in the device i.e. CBD and/or THC and where possible what %

energy drink
type: Class
subclass of: liquid commodity
subclass of: Restriction
  on property: has role
  some values from: psychostimulant
has curation status: Discussed
definition: A liquid commodity that contains a high concentration of sugar, caffeine or another stimulant and is promoted as capable of increasing alertness and reducing fatigue.

grams of alcohol
type: Class
subclass of: data item
has curation status: Discussed
definition: A data item referring to an amount of alcohol expressed in gram units.
comment: Indicate amount in grams

metal
type: Class
subclass of: substance
has curation status: Proposed
definition: Any class of substances characterised by high electrical and thermal conductivity as well as by malleability, ductility and high reflectivity of light.

reproductive toxicant
type: Class
subclass of: toxicant
has curation status: Proposed
definition: A toxicant that has an effect on the reproductive systsem.

respiratory toxicant
type: Class
subclass of: toxicant
has curation status: Proposed
definition: A toxicant that has an effect on the respiratory system.

toxic effect
type: Class
subclass of: quality
has curation status: Proposed
definition: The effect produced by a substance which contains toxins.

toxicant
type: Class
subclass of: substance
has curation status: Discussed
definition: A substance that has a disposition to cause harm to an organism that is in contact with it.

long-term e-cigarette user
type: Class
subclass of: e-cigarette user
has curation status: Proposed
definition: An e-cigarette user who has been using e-cigarettes for one year or more.
alternative term: experienced e-cigarette user

nicotine-containing e-liquid
type: Class
equivalent class: Class
  intersection of: e-liquid
  intersection of: Restriction
    on property: has part
    some values from: nicotine
subclass of: e-liquid
subclass of: Restriction
  on property: has part
  some values from: nicotine
has curation status: Published
definition: An e-liquid that includes nicotine.
alternative term: nicotine e-liquid
comment: The concentration of nicotine in the e-liquid will usually need to be defined for use of this term to be meaningful.

recent ex-smoker
type: Class
subclass of: former tobacco smoker
has curation status: Proposed
definition: An ex-smoker who quit less than a year ago.
alternative term: former smoker
comment: This is a fuzzy because the time frame is not universally agreed and if this term is used, what is meant by recent must be defined.

product attribute
type: Class
subclass of: specifically dependent continuant
has curation status: Proposed
definition: A quality or disposition of a product.
alternative term: product characteristic
curator note: This class is intended to allow reference to anything that is either a quality or disposition of a product.

product harm potential
type: Class
subclass of: product disposition
has curation status: Published
definition: A product disposition that is realised as harm processes resulting from its use.
comment: This entity is only meaningful when operationalised in terms of whether the harm is per individual user, per person or thing being harmed, or whether it is in a population, and the harm itself is defined and operationalised. If the harm being referred to is harm to health, this must be specified.

HIV status
type: Class
subclass of: health status
has curation status: Discussed
definition: A health status which indicates whether or not a person is living with HIV.

adult TB patient
type: Class
subclass of: TB patient
has curation status: Proposed
definition: A TB patient that is of adult age and is currently receiving medical care.
comment: Adult age needs to be defined.

chronic obstructive pulmonary disease
type: Class
subclass of: disease of the respiratory system
has curation status: Proposed
definition: A disease of the respiratory system that causes lung conditions these include emphysema and chronic bronchitis.
alternative term: COPD
definition source: https://www.nhs.uk/conditions/chronic-obstructive-pulmonary-disease-copd/

dual smokeless-containing product user and tobacco smoker
type: Class
subclass of: tobacco-containing product user
has curation status: Proposed
definition: A person that uses both smokeless tobacco-containing products and concurrently smokers tobacco.
alternative term: user of tobacco
comment: The type of smokeless product that is being used should be defined. Also, the frequency of dual use should be reported.

e-cigarette user with COPD
type: Class
subclass of: person with COPD
has curation status: Proposed
definition: A person with COPD that reports current use of an e-cigarette.
alternative term: Vaper with COPD

heated-tobacco containing product user
type: Class
subclass of: smokeless tobacco-containing product user
has curation status: Proposed
definition: A smokeless tobacco-containing product user that uses heated tobacco products.
alternative term: smokeless tobacco user

person living with HIV who smokes
type: Class
subclass of: person living with HIV
has curation status: Proposed
definition: A person who is living with HIV and also reports being a current smoker.
alternative term: HIV positive smoker

person with COPD
type: Class
subclass of: human being
has curation status: Proposed
definition: A person with a clinical status that indicates the person is living with COPD.

person with COPD who currently smokes
type: Class
subclass of: person with COPD
has curation status: Proposed
definition: A person with COPD that reports being a current smoker.
alternative term: current smoking patient with COPD

smokeless tobacco-containing product user
type: Class
subclass of: tobacco-containing product user
has curation status: Proposed
definition: A tobacco-containing product user that uses smokeless tobacco.
alternative term: Smokeless user
comment: There is a wide range of smokeless tobacco-containing products so it is important to state which product/s the user is consuming.

snuff user
type: Class
subclass of: smokeless tobacco-containing product user
has curation status: Proposed
definition: A smokeless tobacco-containing product user that reports using snuff.
alternative term: tobacco user

snus user
type: Class
subclass of: human being
has curation status: Proposed
definition: A person that reports using snus.

TB patient
type: Class
subclass of: human being
has curation status: Proposed
definition: A person living with tuberculosis.

TB patient who smokes
type: Class
subclass of: TB patient
has curation status: Proposed
definition: A TB patient who smokes tobacco.

tobacco-containing product user
type: Class
subclass of: human being
has curation status: Proposed
definition: A person who uses tobacco-containing products.
comment: The type of product that is being used must be defined.

waterpipe smoker
type: Class
subclass of: tobacco-containing product user
has curation status: Proposed
definition: A tobacco-containing product user who reports using a waterpipe.
alternative term: waterpipe user

kretek
type: Class
subclass of: cigarette
has curation status: Discussed
definition: A cigarette made of tobacco and cloves.

cannabis oil
type: Class
subclass of: liquid commodity
has curation status: Discussed
definition: A liquid commodity that is a cannabis extract combined with oil designed to be used in a cannabis vaping device.
alternative term: CO2 oil
comment: It is important to clarify what cannabinoids are present in the oil in what concentrations.

clinical toxicity of a substance
type: Class
subclass of: toxicity of a substance
has curation status: Discussed
definition: Toxicity of a substance that is at or above a level that causes disease.

dry herb tabletop vaporiser
type: Class
subclass of: tabletop vaporiser
has curation status: Discussed
definition: A tabletop vaporiser that is designed to vape cannabis flower or herbs

e-cigarette vapour carbonyl concentration
type: Class
subclass of: concentration
has curation status: Discussed
definition: The concentration of carbonyls in an e-cigarette vapour.

fully branded cigarette pack
type: Class
subclass of: cigarette pack
example of usage: https://bmjopen.bmj.com/content/3/12/e003732
has curation status: Discussed
definition: A cigarette pack that contains the full product brand name and brand imagery printed on it.

nicotine toxicity
type: Class
subclass of: toxicity of a substance
has curation status: Discussed
definition: Toxicity of a substance in which the substance is nicotine.

portable cannabis vaporiser
type: Class
subclass of: cannabis vaping device
has curation status: Discussed
definition: A cannabis vaping device that is portable.
alternative term: handheld dry herb vape
comment: Clarify what cannabis is being vaped i.e. CBD or THC and where possible what %

tabletop vaporiser
type: Class
subclass of: cannabis vaping device
has curation status: Discussed
definition: A cannabis vaping device which is large, usually mains powered and intended for use in one location.
alternative term: desktop vaporiser

toxicity of a substance
type: Class
subclass of: disposition
has curation status: Discussed
definition: A disposition of a substance to cause harm to an organism that is exposed to it.
comment: The substance can be a chemical such as nicotine or ethanol, or a product such as tobacco.

research grant awarding body
type: Class
subclass of: organisation
has curation status: Proposed
definition: An organization that provides funding for research.
alternative term: funder

feasibility study
type: Class
subclass of: research study
has curation status: To Be Discussed
definition: A research study that aims to determine the value of carrying out a full-scale study or intervention and how that study or intervention should be implemented.
definition source: https://pilotandfeasibilitystudies.qmul.ac.uk/introduction/#:~:text=A feasibility study asks whether, conducted on a smaller scale
curator note: There are other definitions available but they do not capture what is needed, including the feasibility and value of a study and finding out how best to carry out the study. This one follows the guidance of Eldridge and colleague (see Source).
comment: Feasibility studies can include assessment of study methods as well as whatever is being studied. This definition does not include full-scale studies that assess the feasibility of an intervention.

feasibility trial
type: Class
subclass of: feasibility study
has curation status: To Be Discussed
definition: A feasibility study that evaluates an intervention.
comment: This is a broader class than pilot trial because a a feasibility trial may involve an evaluation that is not a smaller scale version of a full-scale RCT, for example, trying out a range of different interventions or ways of conducting the trial.

pilot controlled trial
type: Class
subclass of: pilot trial
has curation status: Discussed
definition: A pilot trial in which a controlled trial is being piloted.
curator note: The semantics of this definition are carried by the use of the parent class and the fact that a pilot study is a smaller version of a full-scale study and the full-scale study is a controlled trial.
comment: This entity is intended to provide users with an opportunity to be specific about the nature of the study in that it follows the procedures of a controlled trial where pilot trials include, for example, single arm trials.

pilot randomised controlled trial
type: Class
subclass of: pilot controlled trial
has curation status: Discussed
definition: A pilot controlled trial in which what is piloted is a randomised controlled trial.

pilot study
type: Class
subclass of: feasibility study
has curation status: Discussed
definition: A feasibility study that involves a smaller-scale version or part of the intervention or study whose feasibility is being assessed.
definition source: https://pilotandfeasibilitystudies.qmul.ac.uk/introduction/#:~:text=A feasibility study asks whether,conducted on a smaller scale
curator note: The aim of this definition is to make a useful and clear distinction from feasibility studies. It uses the definition set out by Eldridge and colleagues (see Source).

pilot trial
type: Class
subclass of: pilot study
has curation status: Discussed
definition: A pilot study in which what is being piloted is a trial that evaluates an intervention.
curator note: The aim is to make a clear distinction from both pilot study and feasibility trial. This includes pilot controlled trial as a subclass.
comment: Pilot trials need not be controlled trials. They include single arm trials. Although its parent is 'pilot study' it is also an interventional study.

research literature
type: Class
subclass of: literature
has curation status: Discussed
definition: Literature that is an output of research activity.
alternative term: scientific literature

alcohol sales revenue
type: Class
subclass of: revenue
has curation status: Discussed
definition: The revenue received from the sale of alcohol.

alpha 4 beta 2 nicotinic acetylcholine receptor selective partial agonist
type: Class
subclass of: nicotinic acetylcholine receptor partial agonist
has curation status: Discussed
definition: A nicotinic acetylcholine receptor partial agonist acting selectively on the alpha 4 beta 2 nicotinic acetylcholine receptor

behaviourally-relevant dose of a substance
type: Class
subclass of: data item
has curation status: Discussed
definition: A data item that is the amount of a substance that needs to be taken into the body to provide an observable behavioural effect.

bidi
type: Class
subclass of: combustible tobacco-containing product
has curation status: Published
definition: A combustible tobacco-containing product that is a thin small cylinder of dried leaf containing finely chopped tobacco.
alternative term: beedee
comment: These are usually hand-rolled and include flavouring. They are popular in India. The smoke is usually inhaled into the lungs and so for public health purposes they should be classified with cigarettes.

dry herb atomiser
type: Class
subclass of: product
has curation status: Discussed
definition: A product that is design to be part of a vaping device to heat a cannabis product to produce a vapour for inhalation.
curator note: https://vaping360.com/best-vape-tanks/dry-herb-atomizers/

hand-rolled cigarette
type: Class
subclass of: cigarette
has curation status: Published
definition: A cigarette whose parts have been purchased separately and assembled by hand or using a device for single assembly.
alternative term: RYO

lead (metal)
type: Class
subclass of: chemical entity
has curation status: Proposed
definition: An element with atomic symbol Pb, atomic number 82, and atomic weight 207.2.
definition source: UMLS CUI: C0023175

revenue
type: Class
subclass of: money
has curation status: Discussed
definition: Money that has a revenue role.

revenue role
type: Class
subclass of: role
has curation status: Discussed
definition: A role that inheres in money by virtue of it being acquired by an economic agent for providing a good or service or as a levy.

hookah
type: Class
subclass of: smoking product
has curation status: Published
definition: A smoking product that consists of an open chamber designed to contain organic matter for burning, an enclosed bowl containing water, a flexible hose connected to the bowl and a mouthpiece on the other end, which is used for smoking organic matter.
alternative term: narghile
definition source: https://www.theshishashop.com/blog/2014/03/whats-difference-shisha-hookah/
comment: This is mainly used for smoking tobacco but any kind of organic matter can be smoked using it.

snus
type: Class
subclass of: oral snuff
has curation status: Published
definition: Oral snuff in which tobacco, moisturizers, sodium carbonate, salt (sodium chloride), sweeteners and flavourings are mixed to form a moist product, resulting in very low concentrations of tobacco-specific nitrosamines.
comment: Snus is usually flavoured, but not always. Use usually results in blood nicotine concentrations at least as high as smoking tobacco. They often come in permeable pouches. It is commercially prepared and is consumed by holding in the mouth for 30 minutes or more and does not require chewing, sucking or spitting.

mulled cigarette smoker
type: Class
subclass of: cannabis user
has curation status: Proposed
definition: A cannabis smoker who smokes mulled cigarettes.

cannabis
type: Class
subclass of: commodity
has curation status: Published
definition: A commodity that is formed from parts of the cannabis plant.
alternative term: marijuana

cannabis plant
type: Class
subclass of: whole plant
has curation status: Published
definition: A whole plant that belongs to a species of the genus Cannabaceae.
alternative term: Hemp
comment: May contain a group of compounds known as cannabinoids that are psychoactive.

tobacco leaf product
type: Class
subclass of: tobacco-containing product
has curation status: Proposed
definition: A tobacco-containing product that consists of chopped unprocessed tobacco leaves.

e-cigarette pod
type: Class
subclass of: product
has curation status: Published
definition: A product that is manufactured to be part of an e-cigarette as a combination of a container for e-liquid, an atomiser and systems for controlling the atomiser connected together into a single component.

age of substance use initiation
type: Class
subclass of: human age
has curation status: Proposed
definition: The age at which a person initiated substance use.
alternative term: Age of first cannabis use

cocaine user
type: Class
subclass of: substance user
has curation status: Discussed
definition: A substance user who uses cocaine.

high-risk substance user
type: Class
subclass of: substance user
has curation status: Discussed
definition: A substance user who has a high-risk of adverse outcomes as a result of their substance use.

medicinal cannabis user
type: Class
subclass of: cannabis user
has curation status: Proposed
definition: A cannabis user who users medicinal cannabis.

never opioid user
type: Class
subclass of: human being
has curation status: Proposed
definition: A person who has never used an opioid drug.

opioid user
type: Class
subclass of: substance user
has curation status: Discussed
definition: A substance user who uses an opioid drug.

treatment-seeking alcohol user
type: Class
subclass of: alcohol user
has curation status: Proposed
definition: An alcohol user who is seeking treatment for their alcohol use.

treatment-seeking substance user
type: Class
subclass of: substance user
has curation status: Discussed
definition: A substance user who is in contact with a service to receive treatment for a substance use disorder.

woman who uses psychoactive drugs
type: Class
subclass of: woman
has curation status: Proposed
definition: A woman who self identifies as using psychoactive substances.

woman with MDUI convictions
type: Class
subclass of: woman
has curation status: Proposed
definition: A woman who has convictions for driving under the influence.

young adult
type: Class
subclass of: human being
has curation status: Proposed
definition: A person who is in their late teenage years, or early twenties.
alternative term: young person
comment: Age range should be specified.

young adult alcohol user
type: Class
equivalent class: Class
  intersection of: alcohol user
  intersection of: young adult
subclass of: alcohol user
subclass of: young adult
has curation status: Proposed
definition: A young adult who uses alcohol.
comment: Age (or range) should be specified

young adult binge drinker
type: Class
subclass of: young adult
has curation status: Proposed
definition: A young adult who self-reports as a binge drinker.
curator note: 'young adult' and 'binge drinker'

dry herb vaporiser
type: Class
subclass of: vaping device
has curation status: Published
definition: A vaping device that heats dry herbs in order to create a vapour to be taken into the lungs by the user.

nunu
type: Class
subclass of: smokeless tobacco-containing product
example of usage: https://katukina.com/products/rape/matses-nunu
has curation status: Discussed
definition: A smokeless tobacco-containing product that is designed for nasal use, in which dark coloured Mapacho tobacco, inner bark of Mocambo tree and cacahuilo tree are mixed to form an extremely fine dust.
comment: It is prepared in cottage industries and is blown or snorted high into the nostrils.

gundi
type: Class
subclass of: smokeless tobacco-containing product
example of usage: https://books.google.co.uk/books?id=-Zqo67BjH7UCandpg=PA38andlpg=PA38anddq=how is gundi or kadapan usedandsource=blandots=xLk4geh0hRandsig=ACfU3U1IVfUPFwmdKtSqeE1JNE6Gcc3KYgandhl=enandsa=Xandved=2ahUKEwjB2bep1OnvAhVAgP0HHfw8BDsQ6AEwAnoECAMQAw#v=onepageandq=how is gundi or kadapan usedandf=false https://cancercontrol.cancer.gov/sites/default/files/2020-06/smokelesstobaccoandpublichealth.pdf
has curation status: Discussed
definition: A smokeless tobacco-containing product that is designed for oral use, in which cured tobacco, coriander seeds, and other spices are fried separately and ground, then mixed with aromatic resinous oils to form a coarse powder.
alternative term: Kadapan
comment: Gundi is premade in cottage industry, and it may be chewed as it is or added as ingredient in betel quid.

gutka
type: Class
subclass of: smokeless tobacco-containing product
example of usage: https://untobaccocontrol.org/kh/smokeless-tobacco/paan-betel-quid-tobacco/#ghutka https://cancercontrol.cancer.gov/sites/default/files/2020-06/smokelesstobaccoandpublichealth.pdf
has curation status: Discussed
definition: A smokeless tobacco-containing product that is designed for oral use, in which sun-dried, roasted, and finely chopped tobacco is mixed with areca nut, slaked lime (calcium hydroxide), catechu, and other condiments, sweeteners, and flavourings to create dry granular product.
alternative term: pan/paan masala with tobacco
comment: Gutka is premade commercially or in cottage industry, and it may be held in the mouth and chewed or sucked.

betel quid with tobacco
type: Class
subclass of: smokeless tobacco-containing product
example of usage: https://untobaccocontrol.org/kh/smokeless-tobacco/paan-betel-quid-tobacco https://cancercontrol.cancer.gov/sites/default/files/2020-06/smokelesstobaccoandpublichealth.pdf
has curation status: Discussed
definition: A smokeless tobacco-containing product that is designed for oral use in which tobacco is wrapped in a betel leaf.
alternative term: kun Yar (Myanmar)
comment: The product is custom-made by vendor/individual, and placed in the mouth by users for chewing or holding.It usually includes other ingredients (usually areca nuts, slaked lime, and catechu).

hogesoppu
type: Class
subclass of: smokeless tobacco-containing product
example of usage: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6996481/ https://cancercontrol.cancer.gov/sites/default/files/2020-06/smokelesstobaccoandpublichealth.pdf
has curation status: Proposed
definition: A smokeless tobacco-containing product that is designed for oral use, in which unprocessed and crushed tobacco leaves are bundled in strands.
comment: Hogesoppu is premade in cottage industry, and it may be chewed as it is or added as an ingredient in betel quid.

smoking product
type: Class
subclass of: product
has curation status: Published
definition: A product that is manufactured for a user to taken into the body the products of combustion.
comment: This is a class that covers products that are defined by the fact that their use involves ingesting smoke rather than what is ingested or smoked.

chimó
type: Class
subclass of: smokeless tobacco-containing product
example of usage: https://untobaccocontrol.org/kh/smokeless-tobacco/paan-betel-quid-tobacco https://cancercontrol.cancer.gov/sites/default/files/2020-06/smokelesstobaccoandpublichealth.pdf
has curation status: Discussed
definition: A smokeless tobacco-containing product that is designed for oral use, in which tobacco leaves are crushed and boiled into a sticky, heavy black liquid, which is allowed to mature and seasoned with different ingredients (that vary according to region) to create a tobacco-based paste.
comment: Chimó is produced by small family-operated factories or industrially manufactured, and used by placing a small amount between the lip or cheek and the gum and left there for some time (usually 30 minutes), after which it is spit out.

iq'mik
type: Class
subclass of: smokeless tobacco-containing product
example of usage: https://untobaccocontrol.org/kh/smokeless-tobacco/paan-betel-quid-tobacco/#iqmik https://cancercontrol.cancer.gov/sites/default/files/2020-06/smokelesstobaccoandpublichealth.pdf
has curation status: Proposed
definition: A smokeless tobacco-containing product that is designed for oral use, in which fire- or air-cured tobacco leaves are mixed with tree fungus ash or other ash derived from burning driftwood, alder bush or willow bush to form a thick chewable product.
alternative term: dediguss
comment: it is chewed and users may pre-chew the iq’mik and place it in a small box for later use.
comment: Iq’mik is prepared by the individual user or a family or community member to share

dohra
type: Class
subclass of: smokeless tobacco-containing product
example of usage: https://untobaccocontrol.org/kh/smokeless-tobacco/paan-betel-quid-tobacco/#dohra https://cancercontrol.cancer.gov/sites/default/files/2020-06/smokelesstobaccoandpublichealth.pdf
has curation status: Discussed
definition: A smokeless tobacco-containing product that is designed for oral use, in which different types of tobacco (often zarda or surti) are combined with a mix of areca nut, catechu, slaked lime (calcium hydroxide) and flavorings such as peppermint, cardamom to form a wet mixture.
alternative term: Dhora
comment: Dohra is custom-made by the vendor/individual, and a small amount of it is placed in the mouth and chewed or sucked on.

kaddipudi
type: Class
subclass of: smokeless tobacco-containing product
example of usage: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6996481/ https://cancercontrol.cancer.gov/sites/default/files/2020-06/smokelesstobaccoandpublichealth.pdf
has curation status: Proposed
definition: A smokeless tobacco-containing product that is designed for oral use, in which dried raw tobacco stalks and petioles (sometimes mixed with molasses and water) form loose dry sticks.
comment: kaddipudi is premade in cottage industry, and it is either chewed or added as ingredient in betel quid.

creamy snuff
type: Class
subclass of: smokeless tobacco-containing product
example of usage: https://untobaccocontrol.org/kh/smokeless-tobacco/paan-betel-quid-tobacco https://cancercontrol.cancer.gov/sites/default/files/2020-06/smokelesstobaccoandpublichealth.pdf
has curation status: Discussed
definition: A smokeless tobacco-containing product that is designed for oral use, in which finely ground tobacco is mixed with aromatic substances, salts, water, and other hydrating agents to form a tobacco-based paste that is sold in toothpaste-like tubes.
alternative term: tobacco toothpaste
comment: Creamy snuff is commercially manufactured, and it is applied to teeth and used to clean teeth like regular toothpaste.

khaini
type: Class
subclass of: smokeless tobacco-containing product
example of usage: https://untobaccocontrol.org/kh/smokeless-tobacco/paan-betel-quid-tobacco/#khaini https://cancercontrol.cancer.gov/sites/default/files/2020-06/smokelesstobaccoandpublichealth.pdf
has curation status: Proposed
definition: A smokeless tobacco-containing product that is designed for oral use, in which sun-dried or fermented coarsely cut tobacco leaves are mixed with slaked lime and sometimes areca nut to create a flaky form.
alternative term: surti
comment: Khaini is usually custom-made by individual, but also commercially/cottage industry manufactured, and it is placed in the mouth between the gums and cheeks and sucked slowly for 10 – 15 minutes, or sometimes left overnight in the mouth.

liquid
type: Class
subclass of: quality
has curation status: Discussed
definition: A quality of a substance having no fixed shape but a fixed volume.

dry snuff
type: Class
subclass of: smokeless tobacco-containing product
example of usage: https://cancercontrol.cancer.gov/sites/default/files/2020-06/smokelesstobaccoandpublichealth.pdf
has curation status: Discussed
definition: A smokeless tobacco-containing product that is designed for nasal use, in which tobacco is processed into dry fine powder.
alternative term: snuff
comment: Dry snuff is often flavoured.

kharra
type: Class
subclass of: smokeless tobacco-containing product
example of usage: https://untobaccocontrol.org/kh/smokeless-tobacco/paan-betel-quid-tobacco/#kharra https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6077969/
has curation status: Proposed
definition: A smokeless tobacco-containing product that is designed for oral use, in which tobacco is mixed with areca nut, lime, catechu and additional ingredients to form a coarse powder.
comment: Kharra may be custom-made by vendor/individual or premade in cottage industry, and it is held in the mouth and sucked or chewed.

oil based tabletop vaporiser
type: Class
subclass of: tabletop vaporiser
has curation status: Discussed
definition: A tabletop vaporiser that is designed to vape oil based cannabis products.
comment: Clarify what cannabis is being vaped i.e. CBD or THC and where possible what %

energy-enhanced snuff
type: Class
subclass of: smokeless tobacco-containing product
example of usage: https://cancercontrol.cancer.gov/sites/default/files/2020-06/smokelesstobaccoandpublichealth.pdf
has curation status: Discussed
definition: A smokeless tobacco-containing product that is designed for oral use, in which the tobacco leaf, stems, and seeds are fermented, air- and/or fire-cured, mixed with different flavourings, augmented with stimulants (caffeine, ginseng), taurine, and vitamins B and C, and processed into moist fine particles (fine cut) or strips (long cut).
comment: Energy-enhanced snuff is premade manufactured, and it is placed between the lip or cheek and the gum for holding and sucking.

kiwam
type: Class
subclass of: smokeless tobacco-containing product
example of usage: https://untobaccocontrol.org/kh/smokeless-tobacco/paan-betel-quid-tobacco/#kiwam https://cancercontrol.cancer.gov/sites/default/files/2020-06/smokelesstobaccoandpublichealth.pdf
has curation status: Proposed
definition: A smokeless tobacco-containing product that is designed for oral use, in which boiled tobacco leaves (minus stalks, stems and veins) are soaked in water, then flavoured with powdered spices (e.g., saffron, cardamom, aniseed) and additives such as musk and then prepared into a thick paste that may also be formed into granules or pellets.
alternative term: kimam
comment: Kiwam is commercially manufactured, and it may be chewed alone or inserted into a betel quid.

price per cigarette
type: Class
subclass of: tobacco product price
has curation status: Proposed
definition: The price a person pays or is charged by a company or person for one cigarette.

gudakhu
type: Class
subclass of: smokeless tobacco-containing product
example of usage: https://untobaccocontrol.org/kh/smokeless-tobacco/paan-betel-quid-tobacco/#gudakhu https://cancercontrol.cancer.gov/sites/default/files/2020-06/smokelesstobaccoandpublichealth.pdf
has curation status: Discussed
definition: A smokeless tobacco-containing product that is designed for oral use, in which fine leaf tobacco dust is mixed with molasses, red soil, lime, and water to form a tobacco-based paste.
alternative term: Gudahka
comment: udakhu is premade manufactured, but can also be made by individuals for personal use, and it is used by rubbing on the teeth and gums with a fingertip for cleaning teeth or leaving in the mouth.

loose leaf
type: Class
subclass of: smokeless tobacco-containing product
example of usage: https://cancercontrol.cancer.gov/sites/default/files/2020-06/smokelesstobaccoandpublichealth.pdf
has curation status: Proposed
definition: A smokeless tobacco-containing product that is designed for oral use, in which leaf tobacco is air-cured, stemmed, sweetened and flavoured with sugar and liquorice, and cut or granulated into small strips of shredded tobacco
alternative term: loose leaf chewing tobacco
comment: Loose leaf is commercially manufactured and usually sold in pouches, and a piece of the product is either chewed or held in the mouth and sucked.

gul
type: Class
subclass of: smokeless tobacco-containing product
example of usage: https://untobaccocontrol.org/kh/smokeless-tobacco/paan-betel-quid-tobacco/#gul https://cancercontrol.cancer.gov/sites/default/files/2020-06/smokelesstobaccoandpublichealth.pdf
has curation status: Discussed
definition: A smokeless tobacco-containing product that is designed for oral use, in which pyrolysed (burned and decomposed) tobacco leaves are mixed with ash of tendu leaves to form a fine powder.
comment: it is applied to teeth and gums, usually for cleaning teeth.
comment: Gul is commercially manufactured and sold in small tin cans

mainpuri
type: Class
subclass of: smokeless tobacco-containing product
example of usage: https://untobaccocontrol.org/kh/smokeless-tobacco/paan-betel-quid-tobacco/#mainpuri https://cancercontrol.cancer.gov/sites/default/files/2020-06/smokelesstobaccoandpublichealth.pdf
has curation status: Proposed
definition: A smokeless tobacco-containing product that is designed for oral use, which is composed of small pieces of tobacco leaves treated in slaked lime, finely cut betel nut, flavouring agents and sandalwood powder to form a coarse granular mixture.
alternative term: kapoori
comment: The product is made in cottage industry and is chewed, held or sucked in the mouth.

maras
type: Class
subclass of: smokeless tobacco-containing product
example of usage: https://cancercontrol.cancer.gov/sites/default/files/2020-06/smokelesstobaccoandpublichealth.pdf
has curation status: Proposed
definition: A smokeless tobacco-containing product that is designed for oral use, in which sun-dried tobacco is mixed with ashes from oak, walnut and grapewine and then sprinkled with water to form a moist powder
comment: The product is custom-made by vendor/individual and is applied between the lower lip and gums for 4-5 minutes.

mawa
type: Class
subclass of: smokeless tobacco-containing product
example of usage: https://cancercontrol.cancer.gov/sites/default/files/2020-06/smokelesstobaccoandpublichealth.pdf
has curation status: Proposed
definition: A smokeless tobacco-containing product that is designed for oral use, composed of sun-cured tobacco flakes, thin shavings of areca nut and slaked lime.
comment: Mawa is custom made by vendor/individual and is consumed by placing in the mouth and chewing for 10 to 20 minutes.

mishri
type: Class
subclass of: smokeless tobacco-containing product
example of usage: https://cancercontrol.cancer.gov/sites/default/files/2020-06/smokelesstobaccoandpublichealth.pdf
has curation status: Proposed
definition: A smokeless tobacco-containing product that is designed for oral use, composed of toasted tobacco in a powdered form.
alternative term: masheri
comment: The product is custom made and is applied to the teeth and gums, sucked or used as a dentifrice for cleaning.

moist snuff
type: Class
subclass of: smokeless tobacco-containing product
example of usage: https://cancercontrol.cancer.gov/sites/default/files/2020-06/smokelesstobaccoandpublichealth.pdf
has curation status: Proposed
definition: A smokeless tobacco-containing product that is designed for oral use, which is composed of fermented, air- or fire-cured tobacco mixed with flavourings (spices, essential oils, extracts), sweeteners, inorganic salts, humectants and preservatives and processed into moist fine particles (fine cut) or strips (long cut).
alternative term: moist snuff spit tobacco
comment: The product is prepared commercially and is consumed by placing a pinch or dip between the lip or cheek and gum and holding in the mouth or sucking for 30 minutes.

nass
type: Class
subclass of: smokeless tobacco-containing product
example of usage: https://cancercontrol.cancer.gov/sites/default/files/2020-06/smokelesstobaccoandpublichealth.pdf
has curation status: Discussed
definition: A smokeless tobacco-containing product that is designed for oral use, composed of dried tobacco leaves, ash, cottonseed or sesame oil, water and sometimes gum which are rolled into balls.
alternative term: niswar
comment: The product is custom made and is chewed, held in the mouth and sucked for 10-15 minutes.

nasway
type: Class
subclass of: smokeless tobacco-containing product
example of usage: https://untobaccocontrol.org/kh/smokeless-tobacco/paan-betel-quid-tobacco/#naswar https://cancercontrol.cancer.gov/sites/default/files/2020-06/smokelesstobaccoandpublichealth.pdf
has curation status: Discussed
definition: A smokeless tobacco containing product that is designed for oral use, which is composed of sun or heat dried tobacco leaves mixed with slaked lime, water, ash from tree bark, oil or butter flavourings and colouring agents that are rolled into a ball.
alternative term: nisvai
comment: The product is custom made or prepared in cottage industry and is consumed by placing under the tongue or cheek and holding or sucking for 10 to 15 minutes.

neffa
type: Class
subclass of: smokeless tobacco-containing product
has curation status: Proposed
definition: A smokeless tobacco containing product that is designed for nasal use, that is composed of dried tobacco and made into a fine powder.
alternative term: tenfeha
comment: The product can be premade in cottage industry or custom made and is used nasally to induce sneezing or lighten the head.

orbs
type: Class
subclass of: smokeless tobacco-containing product
example of usage: nytimes.com/2010/04/19/business/19smoke.html
has curation status: Proposed
definition: A smokeless tobacco containing product that is designed for oral use, in which finely ground tobacco, mint or cinnamon flavouring are mixed to form pellets.
comment: The product is commercially prepared and is used by placing in the mouth, holding, sucking or dissolving like breath mints.

pandharpuri
type: Class
subclass of: smokeless tobacco-containing product
example of usage: anilbeediworks.com/tobacco/
has curation status: Proposed
definition: A smokeless tobacco containing product that is designed for oral use, which is composed of dried tobacco flakes.
comment: It is prepared commercially and at the time of use, is mixed with the required proportions of lime to form a moist product that is chewed.

pattiwala
type: Class
subclass of: smokeless tobacco-containing product
example of usage: https://onlinelibrary.wiley.com/doi/pdf/10.1046/j.1440-1843.2003.00507.x
has curation status: Proposed
definition: A smokeless tobacco containing product that is designed for oral use, which is composed of sun-dried flaked tobacco mixed with or without lime.
comment: It is prepared commercially and is consumed by chewing

pituri
type: Class
subclass of: smokeless tobacco-containing product
example of usage: ethnobiomed.biomedcentral.com/articles/10.1186/1746-4269-6-26
has curation status: Proposed
definition: A smokeless tobacco containing product that is designed for oral use, in which sun/fire dried tobacco leaves are mixed with ash to form a quid.
alternative term: mingkupla
comment: The product is custom prepared and is consumed by chewing or holding in the lower lip or cheek for extended periods of time.

plug
type: Class
subclass of: smokeless tobacco-containing product
example of usage: https://untobaccocontrol.org/kh/smokeless-tobacco/paan-betel-quid-tobacco/#plug
has curation status: Proposed
definition: A smokeless tobacco containing product that is designed for oral use, in which Burley and bright tobacco or cigar tobacco leaves, liquorice, and sugar are mixed to form a moist product.
alternative term: pressed leaf
comment: It is commercially packaged and consumed by chewing, sucking or holding between the cheek and gum.

portion snus
type: Class
subclass of: smokeless tobacco-containing product
example of usage: https://academic.oup.com/ntr/article/11/10/1175/1011617
has curation status: Proposed
definition: A smokeless tobacco containing product that is designed for oral use, which is composed of moist finely ground tobacco that is packaged into small teabag like sachets.
comment: It is commercially prepared and is consumed by holding in the mouth between the upperlip and gums.

rapè
type: Class
subclass of: smokeless tobacco-containing product
example of usage: https://untobaccocontrol.org/kh/smokeless-tobacco/paan-betel-quid-tobacco/#rape
has curation status: Proposed
definition: A smokeless tobacco containing product that is designed for nasal use, in which dried tobacco leaf, flavourings such as tonka bean, clove, cinnamon powder, camphor, and in some cases, ashes from select trees are mixed to form a fine powder.
comment: The product is manufactured in cottage industries and consumed by blowing or snorting high into each of the nostrils through a ceremonial pipe made of bone or bamboo.

red toothpowder
type: Class
subclass of: smokeless tobacco-containing product
example of usage: https://untobaccocontrol.org/kh/smokeless-tobacco/paan-betel-quid-tobacco/#lal https://cancercontrol.cancer.gov/sites/default/files/2020-06/smokelesstobaccoandpublichealth.pdf
has curation status: Proposed
definition: A smokeless tobacco containing product that is designed for oral use, in which tobacco, herbs and flavourings are mixed to form a fine red powder.
comment: The product is commercially prepared and applied on teeth and gums and used as a dentifrice to clean teeth.

black shammah
type: Class
subclass of: smokeless tobacco-containing product
example of usage: https://cancercontrol.cancer.gov/sites/default/files/2020-06/smokelesstobaccoandpublichealth.pdf
has curation status: Discussed
definition: A smokeless tobacco containing product that is designed for oral use, in which tobacco, slaked lime, ash, black pepper, oil, flavourings, bombosa (sodium carbonate) are mixed to form a wet product.
alternative term: yemeni snuff
comment: It is custom made by vendor or individual and is consumed by sucking or holding between the gum and lower lip or cheek. In Algeria, users may wrap shammah in paper before putting it in the mouth. Orally chewed or held in the mouth

snuff
type: Class
subclass of: smokeless tobacco-containing product
example of usage: https://untobaccocontrol.org/kh/smokeless-tobacco/paan-betel-quid-tobacco/#snuif
has curation status: Proposed
definition: A smokeless tobacco-containing product in which the tobacco is finely ground to make it suitable for oral or nasal consumption.
alternative term: traditional South African snuff
comment: It is custom made and is used by holding in the mouth or sniffing through the nose.

soft pellete
type: Class
subclass of: smokeless tobacco-containing product
has curation status: Proposed
definition: A smokeless tobacco containing product that is designed for oral use, in which ground tobacco, humectants, preservatives and flavours are compressed into soft pellets.
alternative term: pellet
comment: It is commercially prepared and is consumed by sucking, holding or dissolving in the mouth.

sticks
type: Class
subclass of: smokeless tobacco-containing product
example of usage: https://untobaccocontrol.org/kh/smokeless-tobacco/paan-betel-quid-tobacco/#dissovable
has curation status: Proposed
definition: A smokeless tobacco containing product that is designed for oral use, in which ground tobacco, humectants, preservatives and flavours are compressed to form sticks.
comment: It is commercially prepared and is consumed by sucking, holding or dissolving in the mouth.

strips
type: Class
subclass of: smokeless tobacco-containing product
example of usage: https://untobaccocontrol.org/kh/smokeless-tobacco/paan-betel-quid-tobacco/#dissovable
has curation status: Proposed
definition: A smokeless tobacco containing product that is designed for oral use, in which ground tobacco, humectants, preservatives and flavours are compressed into strips.
comment: It is commercially prepared and is consumed by sucking, holding or dissolving in the mouth.

taaba
type: Class
subclass of: smokeless tobacco-containing product
example of usage: https://untobaccocontrol.org/kh/smokeless-tobacco/paan-betel-quid-tobacco/#ghana
has curation status: Proposed
definition: A smokeless tobacco containing product that is designed for either oral or nasal use, in which dry fermented tobacco is mixed with natron (a mixture of sodium bicarbonate and sodium chloride) and ground into a fine powder. It can be consumed both nasally or orally.
alternative term: Nigerian traditional snuff
comment: The product is custom made or packaged in cottage industries and is used by holding in the mouth or sniffing nasally.

taboka
type: Class
subclass of: smokeless tobacco-containing product
example of usage: ncbi.nlm.nih.gov/pmc/articles/PMC2746834/
has curation status: Proposed
definition: A smokeless tobacco containing product that is designed for oral use, which is composed of tobacco which is sometimes flavoured with menthol and sold as small teabag like pouches.
comment: The product is commercially prepared and consumed by placing the single-serve pouch between the cheek and gums, and disposing of when finished.

tawa
type: Class
subclass of: smokeless tobacco-containing product
example of usage: https://untobaccocontrol.org/kh/smokeless-tobacco/paan-betel-quid-tobacco/#ghana
has curation status: Proposed
definition: A smokeless tobacco containing product that is designed for either oral or nasal use, which is composed of dried tobacco leaf with, saltpeter (potassium nitrate) and ashes which are ground into a fine powder.
alternative term: Ghana traditional snuff
comment: It is premade in cottage industry or custom made by vendor/individuals and is consumed by holding in the mouth or sniffing nasally.

tobacco chewing gum
type: Class
subclass of: smokeless tobacco-containing product
example of usage: https://publications.iarc.fr/Book-And-Report-Series/Iarc-Monographs-On-The-Identification-Of-Carcinogenic-Hazards-To-Humans/Smokeless-Tobacco-And-Some-Tobacco-specific-Em-N-Em--Nitrosamines-2007
has curation status: Proposed
definition: A smokeless tobacco-containing product that is designed for oral use, which is composed of finely ground tobacco , chewing gum base and xylitol.
comment: It is commercially manufactured and used as a chewing gum.

tobacco coated toothpick
type: Class
subclass of: smokeless tobacco-containing product
has curation status: Proposed
definition: A smokeless tobacco-containing product that is designed for oral use, which is composed of nicotine with flavours like strawberry, peppermint, spearmint, coffee, cinnamon etc and is placed in the mouth like a toothpick.
comment: It is commercially prepared and is sucked or sometimes chewed to increase the speed of nicotine release.

tobacco lozenges
type: Class
subclass of: smokeless tobacco-containing product
example of usage: verywellmind.com/the-pros-and-cons-of-nicotine-lozenges-2825034
has curation status: Proposed
definition: A smokeless tobacco containing product that is designed for oral use, that in which ground tobacco is mixed with various flavouring agents like cinnamon, fruit and mint to form a sugar-free tablet.
comment: It is commercially packaged and is consumed by placing in the mouth and allowing to dissolve over the course of 20 to 30 mins.

tobacco tablets
type: Class
subclass of: smokeless tobacco-containing product
example of usage: https://untobaccocontrol.org/kh/smokeless-tobacco/paan-betel-quid-tobacco/#dissovable
has curation status: Proposed
definition: A smokeless tobacco containing product that is designed for oral use, in which ground tobacco, humectants, preservatives and flavours are compressed to form tablets.
alternative term: ariva
comment: It is commercially prepared and is consumed by sucking, holding or dissolving in the mouth.

toombak
type: Class
subclass of: smokeless tobacco-containing product
example of usage: https://cancercontrol.cancer.gov/sites/default/files/2020-06/smokelesstobaccoandpublichealth.pdf
has curation status: Proposed
definition: A smokeless tobacco-containing product, in which sun-dried, fermented, then ground and aged tobacco leaves are mixed with a solution of baking soda and water to create a moist form that can be rolled into a ball (called a saffa).
alternative term: saffa
curator note: query over whether the same product is used nasally - nasal use is not described
comment: Toombak may be premade in cottage industry or custom-made by vendor/individual, and used by holding a small portion (saffa) is the mouth and sucking slowly for 10 to 15 minutes.

tuibur
type: Class
subclass of: smokeless tobacco-containing product
example of usage: https://cancercontrol.cancer.gov/sites/default/files/2020-06/smokelesstobaccoandpublichealth.pdf
has curation status: Proposed
definition: A smokeless tobacco-containing product that is designed for oral use, in which tobacco smoke is passed through water and the resulting tobacco water is sold in glass bottles.
alternative term: hidakphu
comment: Tuibur is premade in cottage industry, and the product is either sipped from a bottle or through cotton soaked with tobacco water. It is retained in the mouth or gargled for 5 to 10 minutes before it is spit out.

twist
type: Class
subclass of: smokeless tobacco-containing product
example of usage: https://cancercontrol.cancer.gov/sites/default/files/2020-06/smokelesstobaccoandpublichealth.pdf
has curation status: Proposed
definition: A smokeless tobacco-containing product that is designed for oral use, in which air- or fire-cured burley tobacco leaf is treated with a tar-like tobacco leaf extract and sometimes sweeteners and other flavourings, then twisted into rope-like strands that are dried and braided.
alternative term: roll
comment: Twist is handmade by commercial manufacturers, and users typically cut off a piece, place it in the mouth, and chew.

zarda
type: Class
subclass of: smokeless tobacco-containing product
example of usage: https://untobaccocontrol.org/kh/smokeless-tobacco/paan-betel-quid-tobacco/#zarda https://cancercontrol.cancer.gov/sites/default/files/2020-06/smokelesstobaccoandpublichealth.pdf
has curation status: Discussed
definition: A smokeless tobacco-containing product that is designed for oral use, in which boiled and dried tobacco leaves are mixed with lime, spices and vegetable dyes (sometimes areca nut and/or silver flecks) to make a flaky product.
alternative term: vizapatta
comment: An oral smokeless tobacco-containing poduct, in which boiled and dried tobacco leaves are mixed with lime, spices and vegetable dyes (sometimes areca nut and/or silver flecks) to make a flaky product. Zarda is commercially manufactured, and it may be chewed by itself, or with chopped areca nuts and spices, or added as an ingredient in betel quid.

afzal
type: Class
subclass of: smokeless tobacco-containing product
example of usage: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4117660/#:~:text=Afzal is used by applying,subsequently spit out the rest.
has curation status: Discussed
definition: A smokeless tobacco-containing product that is designed for oral use in which dried tobacco is mixed with varied additives to create a moist, ground form.
alternative term: Sweekah
comment: In Afzal, some premade ingredients are mixed to create a custom-made product, which is used by placing a pinch of it between the lips and the gums. Users then suck the juice from Afzal for varying periods of time, often up to 30 min, and spit out the rest.

artifact
type: Class
subclass of: object
has curation status: Published
definition: An object that is designed by humans to fulfil some function.
definition source: DOI:10.3233/AO-190210
curator note: This entity is specified in the Product Life Cycle Ontologies reference in the source field. It is not directly imported yet because it is not yet in a form that permits this.

commodity
type: Class
subclass of: material entity
subclass of: Restriction
  on property: has role
  some values from: commodity role
has curation status: Published
definition: A material entity that bears a commodity role.
definition source: DOI: 10.3233/AO-190210
curator note: This is taken from the Product Life Cycle Ontologies specified in the source field. It cannot yet be important because that ontology is not yet set up to allow this.

psychoactive substance
type: Class
subclass of: chemical substance
has curation status: Published
definition: A chemical substance that has a disposition to alter the mental functioning of a person.

white shammah
type: Class
subclass of: smokeless tobacco-containing product
example of usage: https://cancercontrol.cancer.gov/sites/default/files/2020-06/smokelesstobaccoandpublichealth.pdf
has curation status: Proposed
definition: A smokeless tobacco containing product that is designed for oral use, in which tobacco, slaked lime, ash, black pepper, oil, flavourings, bombosa (sodium carbonate) are mixed to form a dry product.
alternative term: yemeni snuff
comment: It is custom made by vendor or individual and is consumed by sucking or holding between the gum and lower lip or cheek. In Algeria, users may wrap shammah in paper before putting it in the mouth. Orally chewed or held in the mouth

oral smokeless tobacco leaf
type: Class
subclass of: smokeless tobacco-containing product
example of usage: https://untobaccocontrol.org/kh/smokeless-tobacco/paan-betel-quid-tobacco/#loose https://cancercontrol.cancer.gov/sites/default/files/2020-06/smokelesstobaccoandpublichealth.pdf
has curation status: Proposed
definition: A smokeless tobacco-containing product, in which raw tobacco leaf is powdered, flaked or sold in bundles of several long strands.
comment: Leaf tobacco is custom-made by vendor/individual, and it may be chewed alone or in a betel quid or other custom-made product. A regular user consumes one 15cm piece of the strand per day.

bajjar
type: Class
subclass of: smokeless tobacco-containing product
example of usage: https://untobaccocontrol.org/kh/smokeless-tobacco/paan-betel-quid-tobacco/#tapkeer https://cancercontrol.cancer.gov/sites/default/files/2020-06/smokelesstobaccoandpublichealth.pdf
has curation status: Discussed
definition: A smokeless tobacco-containing product that is designed for both oral or nasal use, in which fermented, roasted tobacco (sometimes with flavourings) is made into a dry, fine powder.
alternative term: tapkir
comment: Bajjar is frequently prepared by individual users at home (custom-made), and it is typically rubbed on the teeth and gums to clean teeth, but sometimes used nasally.

licensed drug
type: Class
subclass of: drug
has curation status: Published
definition: A drug that has a marketing authorisation from a medicines regulatory agency.

vaping pattern
type: Class
subclass of: behaviour pattern
has curation status: Proposed
definition: A behaviour pattern involving a vaping product.

cannabis-containing e-liquid
type: Class
subclass of: e-liquid
has curation status: Published
definition: E-liquid that includes cannabis or some cannabis extract.

FEV1
type: Class
subclass of: data item
has curation status: Proposed
definition: A data item that is a measure of lung function, and is about the maximal amount of air a person can forcefully exhale in one second.
alternative term: Forced Expiratory Volume

adverse life event
type: Class
subclass of: personal experience
has curation status: Proposed
definition: A personal experience that causes significant lasting harm to the person experiencing it.

biological fluid
type: Class
subclass of: bodily fluid
has curation status: Proposed
definition: A fluid of a biological orgin.

cancer risk
type: Class
subclass of: disease absolute risk
has curation status: Proposed
definition: A disposition of a person involving the probability that exposure to some agent or substance will adversely transform cells to replicate and form a malignant tumor over a defined time period.

GABBR1
type: Class
subclass of: human being
has curation status: Proposed
definition: A protein coding gene in humans.

cardiovascular disease
type: Class
equivalent class: Class
  intersection of: disease
  intersection of: Restriction
    on property: is attribute of
    some values from: cardiovascular system
subclass of: disease
has curation status: Proposed
definition: A disease involving the cardiovascular system.

clinical adverse reaction to treatment
type: Class
subclass of: clinical adverse event following treatment
has curation status: Proposed
definition: A clinical adverse event following treatment that is at least partly caused by the treatment.
alternative term: adverse reaction
definition source: NCIT:C41332

blood pressure
type: Class
subclass of: bodily disposition
has curation status: Proposed
definition: A bodily disposition that is the pressure of circulating blood.
alternative term: BP

cardiovascular disease risk
type: Class
subclass of: disease absolute risk
has curation status: Proposed
definition: A disposition of a person involving the probability of experiencing cardiovascular disease over a defined time period.

third trimester
type: Class
subclass of: trimester
has curation status: Proposed
definition: the last trimester of gestation.
definition: The trimester that ranges from the 28th week of pregnancy until delivery

adult not in treatment for substance use disorder
type: Class
subclass of: adult
has curation status: Discussed
definition: An adult who is currently not receiving any form of intervention for psychoactive substance use disorder.

coronary heart disease
type: Class
subclass of: cardiovascular disease
has curation status: Proposed
definition: A cardiovascular disease in which plaque, a waxy substance, builds up inside the coronary arteries. These arteries supply oxygen-rich blood to the heart muscle.
alternative term: Coronary artery disease
comment: Adapted from OAE:0002134

teenager
type: Class
subclass of: human being
has curation status: Proposed
definition: A person who is between the ages of 13 and 19.

trimester
type: Class
subclass of: temporal region
has curation status: Proposed
definition: especially one of the three months of gestation into which a human pregnancy is divided.
definition: A period of three months

adult patient aged 18 or older with a diagnosis of opioid use disorder
type: Class
subclass of: adult with opioid use disorder
has curation status: Proposed
definition: An adult with a diagnosis of an opioid use disorder that is currently a patient.

cigarette first user
type: Class
subclass of: tobacco user
has curation status: Proposed
definition: A tobacco user who has either only ever smoked cigarettes or who smoked a cigarette as his or her earliest form of tobacco user.

disease of the digestive system
type: Class
equivalent class: Class
  intersection of: disease
  intersection of: Restriction
    on property: is attribute of
    some values from: digestive system
subclass of: disease
has curation status: Proposed
definition: A disease which affects any, or all parts of the digestive system.

adult with opioid use disorder
type: Class
subclass of: adult
has curation status: Proposed
definition: An adult who has received and diagnosis of opioid use disorder

cocaine addiction
type: Class
subclass of: addiction
has curation status: Proposed
definition: An addiction that is to a substance containing cocaine.
alternative term: Cocaine dependence

disease of the respiratory system
type: Class
equivalent class: Class
  intersection of: disease
  intersection of: Restriction
    on property: is attribute of
    some values from: respiratory system
subclass of: disease
has curation status: Proposed
definition: A disease which affects any, or all parts of the respiratory system.

former tobacco smoker with COPD
type: Class
subclass of: former tobacco smoker
has curation status: Discussed
definition: A former tobacco smoker who has been diagnosed as suffering from chronic obstructive pulmonary disease.

musculoskeletal disorder
type: Class
subclass of: disorder
has curation status: Proposed
definition: A disorder which affects the musculoskeletal system, which provides form, support, stability and movement to the body.

myocardial infarction
type: Class
subclass of: coronary heart disease
has curation status: Proposed
definition: A coronary artery disease characterised by myocardial cell death (gross myocardial necrosis), caused by interruption of the blood supply to the heart.

incarcerated persons with opioid use disorder
type: Class
subclass of: person with opioid use disorder
has curation status: Proposed
definition: A person who has an opioid use disorder who is in prison.

never psychoactive substance user
type: Class
subclass of: human being
has curation status: Proposed
definition: A person who has never used a psychoactive drug.

older adult with opioid use disorder
type: Class
subclass of: adult with opioid use disorder
has curation status: Proposed
definition: An older person who has a diagnosis of an opioid use disorder.
curator note: 'older person' and 'opioid use disorder'

nicotine addiction
type: Class
subclass of: addiction
has curation status: Discussed
definition: Addiction to use of a nicotine-containing product.

pregnant woman with opioid use disorder
type: Class
subclass of: opioid user
has curation status: Proposed
definition: A woman who is currently pregnant and also has a diagnosis of opioid use disorder.
curator note: 'pregnant woman' and 'bearer of' some 'opioid use disorder'

HIV transmission
type: Class
subclass of: process attribute
has curation status: Proposed
definition: The process of passing on the human immunodeficiency virus (HIV) infections disease from one carrier to another.

smoker with affective disorder
type: Class
subclass of: tobacco smoker
has curation status: Proposed
definition: A tobacco smoker that also has a diagnosis of affective disorder.
curator note: 'tobacco smoker' and 'bearer of' some 'affective disorder'

cannabis abstainer
type: Class
subclass of: abstainer
has curation status: Proposed
definition: An abstainer from cannabis use.

person living with HIV
type: Class
subclass of: human being
has curation status: Proposed
definition: A person living with HIV.
alternative term: person with HIV

smoker with bipolar disorder
type: Class
equivalent class: Class
  intersection of: tobacco smoker
  intersection of: bipolar disorder
subclass of: tobacco smoker
subclass of: bipolar disorder
has curation status: Proposed
definition: A tobacco smoker that also has a diagnosis of bipolar disorder.

person with substance use disorder
type: Class
subclass of: substance user
has curation status: Discussed
definition: A substance user who has a diagnosis of substance use disorder.

abstainer from tobacco use
type: Class
subclass of: abstainer
has curation status: Proposed
definition: An abstainer from using a tobacco-containing product.

treatment-seeking opioid user
type: Class
subclass of: opioid user
has curation status: Proposed
definition: An opioid user who is seeking treatment for opioid use disorder

prisoner
type: Class
subclass of: human being
has curation status: Proposed
definition: A person who is incarcerated in a prison.

sex worker
type: Class
subclass of: human being
has curation status: Proposed
definition: A person who receives money or goods in exchange for sexual services.
alternative term: sex industry worker
comment: A sex worker may directly or indirectly receive income or goods for their services, this may not be their main occupation, the role may or may not be consensual.

social identity
type: Class
subclass of: self-identity
has curation status: Published
definition: A self-identity that represents a relation between oneself and another person or group.
comment: This can be either a self-identity or a group identity. Possible relations may include membership (of a group), affiliation or antagonism. The group may be a formal group, informal group or collection of people.

urge to vape
type: Class
subclass of: urge
has curation status: Proposed
definition: An urge in which the behaviour that is the target of the feeling is vaping.

vulnerable adult
type: Class
subclass of: adult
has curation status: Proposed
definition: An adult who is unable to look after themselves and or who is unable to protect themselves against significant harm or exploitation.
alternative term: At risk adult

young adult opioid user
type: Class
equivalent class: Class
  intersection of: opioid user
  intersection of: young adult
subclass of: opioid user
subclass of: young adult
has curation status: Proposed
definition: A young adult who uses opioids.
comment: Age should be specified

stimulant drug user
type: Class
subclass of: substance user
has curation status: Discussed
definition: A substance user who uses some stimulant drug.

years of education
type: Class
subclass of: data item
has curation status: Proposed
definition: A data item that indicates the number of years an individual was or has been in education.

amygdala
type: Class
subclass of: anatomical structure
has curation status: Proposed
definition: An almond-shaped cluster of nuclei located within the medial temporal lobe of the brain, which makes up part of the limbic system, that serves a role in memory, emotional reactions and decision-making.

charity
type: Class
subclass of: organisation
has curation status: Proposed
definition: An organisation that raises and distributes funds for charitable purposes.

regulatory agency
type: Class
subclass of: organisation
has curation status: Proposed
definition: An organization that has responsibility over or for the legislation (acts and regulations) for a given sector of the government.
definition source: http://purl.obolibrary.org/obo/OBI_0000450

drug quality
type: Class
subclass of: quality
has curation status: Published
definition: A quality whose bearer is a drug.

plant extract
type: Class
subclass of: extract
subclass of: Restriction
  on property: derives from
  some values from: cannabis plant
has curation status: Published
definition: An extract from a plant.

harm reduction policy
type: Class
subclass of: social policy
has curation status: Published
definition: A social policy whose aim is to reduce the harm to a population from continued use of a psychoactive substance by members of that population.
alternative term: harm minimisation policy
comment: it can include whole commodities such as tobacco.
comment: This entity is defined in terms of the aims of a policy rather than its effect. It is distinguished from harm reduction behaviour. It includes attempting to get people to reduce their use of the substance, change their pattern of use, change the type or formulation of the substance they consume. Note that the substance does not just include the psychoactive drug

harm reduction behaviour
type: Class
subclass of: substance use behaviour pattern
has curation status: Published
definition: A substance use behaviour pattern that involves continuing to use a substance while changing the type of substance, formulation of the substance or the amount or manner of use of the substance with the aim of reducing the harm caused.
alternative term: harm minimisation behaviour

public policy
type: Class
subclass of: policy
has curation status: To Be Discussed
definition: A policy that is applied by a public body.

cocaine use behaviour
type: Class
subclass of: substance use behaviour pattern
has curation status: Proposed
definition: A substance use behaviour in which the substance used is cocaine.

product role
type: Class
subclass of: economic good role
has curation status: Published
definition: An economic good role that inheres in some artifact and is realized in some act of appraisal.
definition source: Product Life Cycle Ontology https://www.researchgate.net/publication/332535504_An_ontological_approach_to_representing_the_product_life_cycle

economic good role
type: Class
subclass of: role
has curation status: Published
definition: A role that inheres in some material entity and is realized in some act of appraisal.

commodity role
type: Class
subclass of: economic good role
has curation status: Published
definition: An economic good role that inheres in some material entity that is not an object and is realized in some act of appraisal.

substance
type: Class
equivalent class: Class
  intersection of: material entity
  intersection of: Class
    complement of: object
subclass of: material entity
has curation status: Discussed
definition: A material entity that is not an object.

cigarette filter
type: Class
subclass of: product
subclass of: Restriction
  on property: part of
  some values from: cigarette
has curation status: Published
definition: A product that is manufactured to be part of a cigarette, located at the end that the user puts to the lips, which blocks some smoke particles from entering the mouth during use.

economic good
type: Class
subclass of: material entity
subclass of: Restriction
  on property: has role
  some values from: economic good role
has curation status: Published
definition: A material entity that has an economic good role.
comment: This includes commodities and products.

product individual-level harm potential
type: Class
subclass of: product harm potential
has curation status: Published
definition: Product harm potential from an individual using the product.
comment: This entity relates to the harmfulness for a given individual. It is distinct from population-level harmfulness which refers to harmfulness to a population. Thus a product may have high individual-level harmfulness but low population-level harmfulness if there are very few users in the population. The individual may be a user of the product (e.g. a smoker) or another person (e.g. a family member of a smoker).

product component
type: Class
subclass of: product
has curation status: Proposed
definition: A product that is designed to be a proper part of another product.

product population-level harm potential
type: Class
subclass of: product harm potential
has curation status: Published
definition: Product harm potential from a population using a product.
comment: This entity refers to the harmfulness for a specified population. It is distinct from individual-level harmfulness which refers to harmfulness for an individual. The harm may be to users or non-users.

product disposition
type: Class
subclass of: disposition
has curation status: Published
definition: A disposition of a product.

average time to relapse
type: Class
subclass of: data item
has curation status: Proposed
definition: A data item which indicates the average time to relapse.
alternative term: time to relapse

change in expenditure on cigarettes
type: Class
subclass of: data item
example of usage: https://www.betterhealth.vic.gov.au/health/HealthyLiving/smoking-the-financial-cost
has curation status: Proposed
definition: A data item which indicates changes in expenditure on cigarettes between defined time points.
alternative term: changes in money spent on cigarettes.

e-cigarette use behaviour pattern
type: Class
subclass of: inhaling consumption behaviour pattern
has curation status: Discussed
definition: An inhaling consumption behaviour pattern that involves use of an e-cigarette.
alternative term: vaping

desire
type: Class
subclass of: subjective affective feeling
has curation status: Proposed
definition: A subjective emotional feeling which consists of a strong wanting or wishing to have something or for something to happen.

aversion
type: Class
subclass of: mental disposition
has curation status: Proposed
definition: A mental disposition that consists of a strong dislike or disinclination towards an object, situation or behaviour

aversion to smoking
type: Class
subclass of: aversion
has curation status: Proposed
definition: An aversion towards cigarette smoking

alcohol consumption pattern
type: Class
subclass of: substance use behaviour pattern
has curation status: Discussed
definition: A substance use behaviour pattern in which the substance used is alcohol.

cannabis use behaviour pattern
type: Class
subclass of: substance use behaviour pattern
has curation status: Proposed
definition: A substance use behaviour pattern that involves use of cannabis.

heroin use behaviour pattern
type: Class
subclass of: opioid use behaviour pattern
has curation status: Proposed
definition: An opioid use behaviour pattern that involves use of heroin.

opioid use behaviour pattern
type: Class
subclass of: substance use behaviour pattern
has curation status: Proposed
definition: A substance use behaviour pattern in which the substance used is an opioid.

nicotine replacement therapy product
type: Class
subclass of: nicotine-containing product
has curation status: To Be Discussed
definition: A nicotine-containing product that some country has granted marketing authorisation as a medicine to replace nicotine from tobacco in an attempt to reduce or stop smoking.
alternative term: NRT
comment: This class is problematic because as products have evolved distinctions between those receiving a license to be marketed as medicines and those that have not have become blurred. It is better to use the parent class 'nicotine-containing product' or the more accurate 'licensed nicotine-containing product'.

addiction strength
type: Class
subclass of: personal attribute
has curation status: Discussed
definition: A personal attribute that is the strength of motivation experienced to engage in the behaviour to which the person is addicted.

e-cigarette user identity
type: Class
subclass of: self-identity
has curation status: Published
definition: A self-identity in which a person represents themselves as an e-cigarette user.
alternative term: vaper identity

social policy
type: Class
subclass of: policy
has curation status: To Be Discussed
definition: A plan detailing guidelines, principles, legislation and activities that affect the living conditions conducive to human welfare, such as a person's quality of life.
definition source: https://www.ebi.ac.uk/ols/ontologies/gsso/terms
curator note: This is drawn from the GSSO but with wording and parentage corrected.

competing interest
type: Class
subclass of: mental disposition
has curation status: Discussed
definition: A mental disposition to experience motives in the performance of an activity that are not aligned with the purported goals of that activity.
curator note: Curator note: The definition was adapted from the PLOS definition. https://journals.plos.org/plosbiology/s/competing-interests

potential competing interest
type: Class
subclass of: personal attribute
has curation status: Discussed
definition: A personal attribute that is objectively identifiable and could lead to a competing interest.
comment: Potential competing interests are distinguished from competing interests. They should always be disclosed so that stakeholders can assess the risk of bias.

research bias
type: Class
subclass of: research activity attribute
has curation status: Discussed
definition: A research activity attribute that is the extent to which the output of research or its communication systematically deviates from a balanced and objective perception of the topic of the research.
comment: This class refers to actual bias that results in a given research process. This process may be a whole study or some part of a study such as a measurement.

harm reduction facility
type: Class
subclass of: health care facility
has curation status: Discussed
definition: A health care facility that provides harm reduction services to substance users.

addiction clinic
type: Class
subclass of: health care facility
has curation status: Discussed
definition: A health care facility that treats and manages addictive disorders.

alcohol outlet
type: Class
subclass of: facility
has curation status: Discussed
definition: A facility where some alcoholic beverage can be purchased.

alcohol outlet density
type: Class
subclass of: data item
has curation status: Discussed
definition: A data item that is about the number of alcohol outlets per unit area within a geographical location.

antenatal clinic
type: Class
subclass of: health care facility
has curation status: Discussed
definition: A health care facility that provides services to people who are pregnant and their partners.

health and social care facility
type: Class
subclass of: facility
has curation status: Discussed
definition: A facility that provides housing, health care and social care.

accessibility of addiction treatment
type: Class
subclass of: accessibility of a service
has curation status: Discussed
definition: Accessibility of a service in which the service is addiction treatment.

English-speaking country
type: Class
subclass of: country
has curation status: Discussed
definition: A country in which English is an official language.

country
type: Class
subclass of: spatial region
has curation status: Discussed
definition: A spatial region that has a government and is recognised as a country in international law.
definition source: http://www.ontologyrepository.com/CommonCoreOntologies/Country
curator note: Definition taken from the VIDO ontology but this does not have appropriate codes so we have created a separate entity.

mental health disorder
type: Class
subclass of: disorder
has curation status: To Be Discussed
definition: A disorder that involves mental processes.
definition source: MF defines mental disease as a disposition to pathological *mental* processes which is not quite right. Needs work
curator note: Should be primarily defined in MF

positive self-appraisal
type: Class
subclass of: self-appraisal
has curation status: Published
definition: A self-appraisal in which what is represented is appraised as good or desirable.

negative self-appraisal
type: Class
subclass of: self-appraisal
has curation status: Published
definition: A self-appraisal in which what is represented is appraised as bad or undesirable.

addict identity
type: Class
subclass of: self-identity
has curation status: Published
definition: A self-identity in which a person represents themselves as being addicted to something.

ex-addict identity
type: Class
subclass of: self-identity
has curation status: Published
definition: A self-identity in which a person represents themselves as having been addicted to something but no longer addicted to that thing.

recovering addict identity
type: Class
subclass of: self-identity
has curation status: Published
definition: A self-identity in which a person represents themselves as being in recovery from addiction and vulnerable to relapse to that addiction.

social smoker identity
type: Class
subclass of: self-identity
has curation status: Published
definition: A self-identity in which the person considers themselves to smoke predominantly or exclusively in social situations.
comment: This is not a subclass of tobacco smoker identity because not all social smokers may consider themselves to be smokers as they do not smoke sufficiently often. This class is intended for tobacco smokers.

lost tobacco smoker identity
type: Class
subclass of: lost self-identity
has curation status: Published
definition: A lost self-identity in which the positively appraised past characteristic is that of being a tobacco smoker

positive core non tobacco smoker identity
type: Class
equivalent class: Class
  intersection of: core identity
  intersection of: non tobacco smoker identity
  intersection of: positive self-appraisal
subclass of: core identity
subclass of: non tobacco smoker identity
subclass of: positive self-appraisal
has curation status: Published
definition: A non tobacco smoker identity that is a core identity and a positive identity.

spoiled tobacco smoker identity
type: Class
equivalent class: Class
  intersection of: tobacco smoker identity
  intersection of: spoiled self-identity
subclass of: tobacco smoker identity
subclass of: spoiled self-identity
has curation status: Published
definition: A tobacco smoker that is also a spoiled identity.

gender inequality
type: Class
subclass of: inequality
has curation status: To Be Discussed
definition: Inequality between different gender groups.

health inequality
type: Class
subclass of: inequality
has curation status: To Be Discussed
definition: Inequality in health and access to healthcare.
comment: Health inequality can be operationalised in many ways and these need to be specified when the class is used.

inequality
type: Class
subclass of: quality
has curation status: To Be Discussed
definition: A quality of a population that is the degree of variation among members of the population on some valued attribute.
curator note: The GSSO definition http://purl.obolibrary.org/obo/GSSO_002956 is not well-formed and so one had to be constructed.

man
type: Class
subclass of: human being
has curation status: Proposed
definition: A person whose identity is male, based on societal and cultural conceptualizations of being male, usually (but not always) reflected by specific anatomical variations, chromosome combinations, and/or sex hormones.
alternative term: boy
definition source: http://purl.obolibrary.org/obo/GSSO_000370

man who has sex with men
type: Class
subclass of: man
has curation status: Proposed
definition: Male persons who engage in sexual activity with members of the same sex, regardless of how they identify themselves.
definition source: http://purl.obolibrary.org/obo/GSSO_000376

man who has sex with women
type: Class
subclass of: man
has curation status: Proposed
definition: Male persons who engage in sexual activity with women, regardless of how they identify themselves.
definition source: http://purl.obolibrary.org/obo/GSSO_001596

man who has sex with women and men.
type: Class
subclass of: man
has curation status: Proposed
definition: Male persons who engage in sexual activity with men and women, regardless of how they identify themselves.
definition source: http://purl.obolibrary.org/obo/GSSO_001802

non binary person
type: Class
subclass of: human being
has curation status: Proposed
definition: a person having a gender identity which is outside of the gender binary (i.e. male and female).
definition: A person whose gender identity is not exclusively male or female
definition source: http://purl.obolibrary.org/obo/GSSO_000395

racial inequality
type: Class
subclass of: inequality
has curation status: To Be Discussed
definition: Inequality between different racial or ethnic groups.

social inequality
type: Class
subclass of: inequality
has curation status: To Be Discussed
definition: Inequality in access to social or material resources.

transgender person
type: Class
subclass of: human being
has curation status: Proposed
definition: A person whose gender identity does not match their gender assigned at birth or a person who otherwise identifies as transgender
alternative term: trans
definition source: http://purl.obolibrary.org/obo/GSSO_000130

woman
type: Class
subclass of: human being
has curation status: Proposed
definition: A person whose identity is female, based on societal and cultural conceptualizations of being female, usually (but not always) reflected by specific anatomical variations, chromosome combinations, and/or sex hormones.
alternative term: women
definition source: http://purl.obolibrary.org/obo/GSSO_000369

woman who has sex with men
type: Class
subclass of: woman
has curation status: Proposed
definition: Women who engage in sexual activity with men, regardless of how they identify themselves.
definition source: http://purl.obolibrary.org/obo/GSSO_001595

woman who has sex with men and women
type: Class
subclass of: woman
has curation status: Proposed
definition: Female persons who engage in sexual activity with men and women, regardless of how they identify themselves.
definition source: http://purl.obolibrary.org/obo/GSSO_004516

woman who has sex with women
type: Class
subclass of: woman
has curation status: Proposed
definition: Women who engage in sexual activities with other women, whether or not they identify themselves as lesbian, bisexual, heterosexual, or dispense with sexual identification altogether.
definition source: http://purl.obolibrary.org/obo/GSSO_000379

daily nicotine replacement therapy user
type: Class
subclass of: nicotine replacement therapy user
has curation status: Discussed
definition: A nicotine replacement therapy user who engages in nicotine replacement therapy use every day.
alternative term: NRT user
comment: The type of nicotine replacement therapy (NRT) used should be specified. It may also be useful in the reporting of studies to quantify the amount of NRT used and the strength.

nicotine replacement therapy user
type: Class
subclass of: human being
example of usage: This is definition used across studies and also within the reporting of NRT use in the Smoking Toolkit Study: www.smokinginengland.info
has curation status: Proposed
definition: A person who participates in nicotine replacement therapy use.
alternative term: NRT user
comment: The type of nicotine replacement therapy (NRT) used should be specified. It may also be useful in the reporting of studies to quantify the amount of NRT used and the strength.

non-daily nicotine replacement therapy user
type: Class
subclass of: nicotine replacement therapy user
has curation status: Proposed
definition: An NRT user who does not use their product on a daily basis.
alternative term: NRT user
comment: The product or products used should be specified.

exclusive nicotine replacement therapy user
type: Class
subclass of: nicotine replacement therapy user
has curation status: Discussed
definition: A nicotine replacement therapy user who is not a tobacco user or an e-cigarette user.
alternative term: exclusive NRT user
comment: Exclusive user referes to the complete absense of tobacco containing products.

long-term nicotine replacement therapy user
type: Class
subclass of: nicotine replacement therapy user
has curation status: Proposed
definition: A nicotine replacement therapy user who has been using NRT products for one year or more.
alternative term: long term NRT use
comment: The NRT product or products used should be specified.

tobacco user
type: Class
subclass of: substance user
has curation status: Discussed
definition: A substance user who engages in tobacco use.

e-cigarette atomiser resistance
type: Class
subclass of: e-cigarette atomiser quality
has curation status: Published
definition: An e-cigarette atomiser quality that is the opposition of its circuit to the flow of current in that circuit.

e-cigarette atomiser quality
type: Class
subclass of: quality
has curation status: Discussed
definition: A quality inhering in an e-cigarette atomiser.

e-cigarette battery power
type: Class
subclass of: e-cigarette battery disposition
has curation status: Published
definition: An e-cigarette battery disposition to transfer electrical energy in a circuit containing an atomiser.

manufactured cigarette disposition
type: Class
subclass of: disposition
has curation status: Discussed
definition: A disposition inhering in a manufactured cigarette

manufactured cigarette machine-smoked carbon monoxide yield
type: Class
subclass of: manufactured cigarette disposition
has curation status: Published
definition: A disposition of a manufactured cigarette to produce a quantity of carbon monoxide in the smoke produced when tested in a smoking machine that is programmed to take puffs in a standard way.

manufactured cigarette machine-smoked nicotine yield
type: Class
subclass of: manufactured cigarette disposition
has curation status: Published
definition: A disposition of a manufactured cigarette to produce a quantity of nicotine in the smoke produced when tested in a smoking machine that is programmed to take puffs in a standard way.

oral tobacco-containing product
type: Class
subclass of: smokeless tobacco-containing product
has curation status: Published
definition: A smokeless tobacco-containing product that is manufactured to be held in the mouth.
comment: This includes chewing tobacco products.

inhaled nicotine-containing product
type: Class
subclass of: nicotine-containing product
has curation status: Published
definition: A nicotine-containing product that is manufactured to enable users to draw a nicotine-containing vapour into the respiratory tract so that nicotine can be absorbed through the lining of this tract.

nasal nicotine-containing product
type: Class
subclass of: nicotine-containing product
has curation status: Published
definition: A nicotine-containing product that is manufactured to enable users to absorb nicotine through the nasal mucosa.

transdermal nicotine-containing product
type: Class
subclass of: nicotine-containing product
has curation status: Published
definition: A nicotine-containing product that is manufactured to be attached to the skin so that nicotine can be absorbed through the skin.

electrical battery
type: Class
subclass of: product
has curation status: Discussed
definition: A product that stores chemical energy and converts it to electrical energy.

manufactured cigarette machine-smoked tar yield
type: Class
subclass of: manufactured cigarette disposition
has curation status: Published
definition: A disposition of a manufactured cigarette to produce a quantity of tobacco particles in the smoke produced when tested in a smoking machine that is programmed to take puffs in a standard way.

e-cigarette battery disposition
type: Class
subclass of: disposition
has curation status: Discussed
definition: A disposition inhering in an e-cigarette battery.

filter cigarette
type: Class
subclass of: cigarette
subclass of: Restriction
  on property: has part
  some values from: cigarette filter
has curation status: Published
definition: A cigarette that has a cigarette filter as a part.

oral nicotine-containing product
type: Class
subclass of: nicotine-containing product
has curation status: Published
definition: A nicotine-containing product that is designed to be held in the mouth or chewed so that nicotine is absorbed through the buccal mucosa.

substance dependence
type: Class
subclass of: bodily disposition
has curation status: Published
definition: A bodily disposition which is realised as impaired functioning following reduction or termination of use of a psychoactive substance as a result of long-term physiological adaptation to that substance.
comment: This is distinguished from addiction. The two are often correlated but distinct. Dependence is a disposition to experience impaired functioning, which includes withdrawal symptoms, while addiction is a disposition to experience powerful motivation. The motivation can, but need not be caused by impaired functioning.

nicotine dependence
type: Class
subclass of: substance dependence
has curation status: Discussed
definition: Substance dependence in which the dependence is on nicotine.

cigarette addiction
type: Class
subclass of: tobacco addiction
has curation status: Discussed
definition: Tobacco addiction where there tobacco-containing product is cigarettes.

tobacco addiction
type: Class
subclass of: addiction
has curation status: Discussed
definition: Addiction to a tobacco-containing product.

subjective opioid craving
type: Class
subclass of: subjective craving
has curation status: Discussed
definition: Subjective craving in which the target of the craving is use of an opioid drug.

situational subjective craving
type: Class
subclass of: subjective craving
has curation status: Discussed
definition: Subjective craving that is wholly or mostly triggered by the immediate environment or part of it.

background subjective craving
type: Class
subclass of: subjective craving
has curation status: Discussed
definition: Subjective craving that is mostly or completely independent of the immediate environment.
comment: This aims to capture craving that is caused by endogenous drive processes or withdrawal symptoms.

subjective alcohol craving
type: Class
subclass of: subjective craving
has curation status: Discussed
definition: Subjective craving whose target is consumption of an alcoholic beverage.

age of tobacco use initiation
type: Class
subclass of: age of substance use initiation
has curation status: Proposed
definition: An age of substance use initiation in which the substance is tobacco.

cigarette dependence
type: Class
subclass of: substance dependence
has curation status: Proposed
definition: A substance dependence in which the dependence is on use of cigarettes.

composite self-identity
type: Class
subclass of: self-identity
has curation status: Published
definition: An identity that includes all of a person’s self-identities

positive core tobacco smoker identity
type: Class
equivalent class: Class
  intersection of: core identity
  intersection of: tobacco smoker identity
  intersection of: positive self-appraisal
subclass of: core identity
subclass of: positive tobacco smoker identity
has curation status: Published
definition: A tobacco smoker identity that is a core identity and a positive identity.

strong identity
type: Class
subclass of: self-identity
has curation status: Published
definition: A self-identity in which what is represented is appraised as important.
comment: If the characteristic represented is appraised as both important and enduring the appropriate class is 'core identity'.

behavioural attribute
type: Class
subclass of: process attribute
has curation status: Discussed
definition: A process attribute in which the process is an individual human behaviour.
curator note: This entity has been taken from the Behaviour Change Intervention Ontology.

packaging
type: Class
subclass of: product
has curation status: Discussed
definition: A product that is designed to contain a product or commodity when sold.

individual-level relative harmfulness of a product
type: Class
subclass of: data item
has curation status: Discussed
definition: A data item that is about the amount of harm caused by an individual using a product relative to using another product.

airborne particulate matter
type: Class
subclass of: object aggregate
has curation status: Discussed
definition: An object aggregate that consists of particles of solids and liquids suspended in air.

harm process
type: Class
subclass of: process
has curation status: Discussed
definition: A process in which there is damage to or destruction of something that is valued.
comment: This entity involves harm as a process rather than as a negatively valued state of affairs more generally because that is the usage that appears to be most common in the fields of addiction, behavioural, clinical and public health sciences. The definition includes a subjective component regarding the value of the entity being damaged or destroyed. This is required because not all damage or destruction would be considered harm. It also allows the possibility that harm may occur to achieve a greater benefit as in the case of surgery.

nicotinic acetylcholine receptor partial agonist
type: Class
subclass of: receptor partial agonist
has curation status: Discussed
definition: A receptor partial agonist acting on the nicotine acetylcholine receptor.

receptor partial agonist
type: Class
subclass of: pharmacological role
has curation status: Discussed
definition: A pharmacological role of a substance that binds to cell receptors normally responding to naturally occurring substances and which produces a response of its own but only up to a certain concentration.

substance dependence potential
type: Class
subclass of: disposition
has curation status: Discussed
definition: A disposition of a psychoactive substance to result in substance dependence in people who use it.

preferred drug dispositon
type: Class
subclass of: mental disposition
has curation status: Discussed
definition: A mental disposition to prefer a psychoactive substance to other psychoactive substances.

pharmaceutical disposition
type: Class
subclass of: disposition
has curation status: Discussed
definition: A disposition inhering in a pharmaceutical.

pharmaceutical effectiveness
type: Class
subclass of: pharmaceutical disposition
has curation status: Proposed
definition: A pharmaceutical disposition to ameliorate or cure some symptom or medical condition when the pharmaceutical is used under typical conditions.

pharmaceutical efficacy
type: Class
subclass of: pharmaceutical disposition
has curation status: Proposed
definition: A pharmaceutical disposition to ameliorate or cure some symptom or medical condition when the pharmaceutical is used as specified.

cross-over study design
type: Class
subclass of: mixed study design
has curation status: Discussed
definition: A mixed study design in which two or more groups experience the same study processes but in a different order.
comment: Note that the term 'study processes' is used here rather than interventions because there may be no intervention involved (e.g. when different forms of measurement are being compared in different orders)

follow-up rate
type: Class
subclass of: data item
has curation status: Discussed
definition: A data item that describes the percentage of study participants for whom a measurement is taken at a follow-up point.

case-control study design
type: Class
subclass of: non-interventional study design
has curation status: Discussed
definition: A non-interventional study design in which study participants who have been identified as having (case) or not having (control) some characteristic of interest are compared on other characteristics to establish whether these are associated with being a case or control.

non-interventional study design
type: Class
subclass of: study design
has curation status: Discussed
definition: A study design in which study participants are not planned to experience an intervention as a part of the study process.
alternative term: observational study design

study participation allocation process
type: Class
subclass of: planned process
has curation status: Discussed
definition: A planned process to choose which of two or more study processes will be applied to a study participant.

study randomisation processes
type: Class
subclass of: study participation allocation process
has curation status: Discussed
definition: A study participation allocation process in which allocation of study participants to study processes is undertaken using a random process.
alternative term: Randomised Controlled Trial
comment: Random processes include pseudo-random processes: for example, random number generation by a computer.

physical personal attribute
type: Class
subclass of: personal attribute
has curation status: Discussed
definition: A personal attribute that inheres in a person by virtue of their bodily makeup.
comment: Includes dispositions such as strength and well as metrics such as height.

repeated measures study design
type: Class
subclass of: study design
has curation status: Discussed
definition: A study design in which measurements taken on the same study participants at two or more different times in different circumstances are compared.
comment: Distinguished in common usage from longitudinal study design that usually involves repeated measurements over an extended period with no stipulation about the conditions preceding or surrounding the measurement.

randomised controlled trial design
type: Class
subclass of: interventional study design
has curation status: Discussed
definition: An interventional study design in which participants are randomly allocated to receive one of two or more interventions or no intervention using a study randomisation process.
alternative term: parallel group RCT 'parallel group RCT'

non-response to follow up rate
type: Class
subclass of: data item
has curation status: Discussed
definition: A data item that is the percentage of study participants who were eligible for follow-up but could not be contacted at a follow-up point.
comment: This class is used for study participants who were eligible for follow-up but could not be contacted.

mixed study design
type: Class
subclass of: study design
has curation status: Discussed
definition: A study design in which measurements taken on two or more groups of study participants at two or more times are compared allowing differences to be assessed between groups and over time.

loss to follow-up rate
type: Class
subclass of: data item
has curation status: Discussed
definition: A data item that is the percentage of study participants for whom measurements are not taken at a follow-up.
comment: This class includes participants who may be been contacted but whom for whatever reason did not provide data at the follow-up.

interventional study design
type: Class
subclass of: study design
has curation status: Discussed
definition: A study design that includes specification of some intervention as part of the study process.
alternative term: experimental study design
comment: This class is for any study in which an activity is undertaken for the purposes of the study, usually for the purpose of evaluating its effect.

follow-up visit
type: Class
subclass of: research activity
has curation status: Discussed
definition: A research activity in which a participant visits a research facility or is visited by a researcher for the purpose of taking some measurement.

follow-up point
type: Class
subclass of: temporal region
has curation status: Discussed
definition: A temporal region during which a follow-up occurs.
comment: This is often specified as a time point but in practice is always a period of time to allow for participants to be contacted and measurements taken.

two-arm parallel group randomised controlled trial design
type: Class
subclass of: randomised controlled trial design
has curation status: Discussed
definition: A randomised controlled trial design with two study arms to which participants can be allocated.

sequential multiple randomised controlled trial design
type: Class
subclass of: randomised controlled trial design
has curation status: Discussed
definition: A randomised controlled trial design in which participants are randomised to study on more than one occasion during the study.

difference-in-differences study design
type: Class
subclass of: mixed study design
has curation status: Discussed
definition: A mixed study design in which measures are taken in two or more groups of participants before one or more of them receives an intervention and then measurements are repeated so that changes in the measures can be compared.
comment: The purpose of the study is to compare changes in some variable as a function of one or more interventions. The interventions could be naturally occurring as in a quasi-experimental study or delivered as part of the research process as in an interventional study. If it is an interventional study and participants are randomised to study groups/arms this would be a form of randomised controlled trial.

public health promotion policy
type: Class
subclass of: public policy
has curation status: Discussed
definition: A public policy that aims to improve the health of a population.

harmful product-use behaviour
type: Class
subclass of: product-use behaviour
has curation status: Discussed
definition: Product use behaviour that is harmful.

excessive product-use behaviour
type: Class
subclass of: harmful product-use behaviour
has curation status: Discussed
definition: Harmful product-use behaviour where the harm arises from a high level of use.

cocaine binge session
type: Class
subclass of: binge behaviour session
has curation status: Discussed
definition: A binge behaviour session in which the behaviour is cocaine use.

cluster randomised controlled trial design
type: Class
subclass of: randomised controlled trial design
has curation status: Discussed
definition: A randomised controlled trial design in which pre-existing groups of participants are randomly allocated to intervention arms.
comment: Distinguished from individually randomised controlled trial design.

single-arm interventional study design
type: Class
subclass of: interventional study design
has curation status: Discussed
definition: An interventional study design in which all the participants receive the same type of intervention.
alternative term: single arm study design

important other
type: Class
subclass of: human being
has curation status: Discussed
definition: A person with whom someone has a sufficiently close relationship that they are willing to discuss important matters.

important other who smokes
type: Class
subclass of: important other
has curation status: Discussed
definition: An important other who smokes tobacco.

important other who vapes nicotine
type: Class
subclass of: important other
has curation status: Discussed
definition: An important other who vapes nicotine.

number of important others in a person's social environment
type: Class
subclass of: data item
has curation status: Discussed
definition: A data item that is the number of important others in a person's environmental system.

number of important others who smoke tobacco in a person's social environment.
type: Class
subclass of: data item
has curation status: Discussed
definition: A data item that is the number of important others who smoke tobacco in a person's social environment.

number of important others who vape nicotine in a person's social environment.
type: Class
subclass of: data item
has curation status: Discussed
definition: A data item that is the number of important others who vape nicotine in a person's social environment.

past-30 day binge drinking frequency
type: Class
subclass of: data item
has curation status: Discussed
definition: A data item describing how often a person has engaged in a binge drinking session within the past 30 days.
comment: This class is expressed as a number. If just whether or not there has been binge drinking is required use 'past 30-day binge drinking occurrence'

study design
type: Class
subclass of: plan specification
has curation status: Discussed
definition: A plan specification that describes the way a research study should be conducted in terms of what kind of data are collected, how the data are collected and the circumstances in which they are collected.
comment: The design is the specification that may be realised as a research study.

4-week follow-up
type: Class
subclass of: follow-up
has curation status: Discussed
definition: Follow-up that occurs at the 4-week follow-up point.

research activity attribute
type: Class
subclass of: process attribute
has curation status: Discussed
definition: A process attribute of a research activity.
alternative term: study attribute

statistical interaction
type: Class
subclass of: statistical parameter
has curation status: Discussed
definition: A statistical parameter that describes the extent and manner in which two or more variables combine to influence or predict an outcome variable.

statistical parameter
type: Class
subclass of: data item
has curation status: Discussed
definition: A data item that is output from a statistical analysis describing a feature of a data set.

n-of-1 study design
type: Class
subclass of: repeated measures study design
has curation status: Discussed
definition: A repeated measures study design involving multiple repeated measurements taken in each of two or more conditions facilitating inferential statistical analyses to be undertaken to output statistical parameters from data sets for each individual participant.
comment: This class of design may involve multiple participants, each with a set of parameter estimates which have the potential to be aggregated in further statistical analyses.

double-blind study design
type: Class
subclass of: interventional study design
has curation status: Discussed
definition: An interventional study design in which neither the investigators carrying out the study nor the participants are informed about which of two or more interventions the participants are to experience until the data set has been locked in preparation for the statistical analysis to be carried out.
comment: Note that the participants might end up knowing what intervention they have experienced. The design merely states that they should not be informed about this. The definition makes clear that this only applies to study designs with two or more interventions. Participants may or may not be informed about what interventions they could be allocated to. This study design may or may not involve randomisation. It can be combined with other classes of study design to more fully describe study designs, e.g., double-blind individually randomised controlled trial.

unblinded study design
type: Class
subclass of: interventional study design
has curation status: Discussed
definition: An interventional study design in which study participants are informed which of two or more interventions that they are to experience.
comment: Unblinded studies can be single-arm trials as well as multi-arm trials.

triple-blind study design
type: Class
subclass of: interventional study design
has curation status: Discussed
definition: An interventional design in which those carrying out the study, the participants and those specifying the statistical analyses are not informed of what intervention each participant will experience until after the data set is locked in preparation for the statistical analysis to be carried out.

statistical analysis
type: Class
subclass of: research activity
has curation status: Discussed
definition: A research activity in which parameters estimates describing features of a data set are output.

cross-over research study
type: Class
subclass of: research study
has curation status: Discussed
definition: A research study that implements a cross-over study design.

single-blind study design
type: Class
subclass of: interventional study design
has curation status: Discussed
definition: An interventional study design in which the participants are not informed about which of two or more interventions they are to experience until after an endpoint has been reached.
comment: Participants may be unblinded before the end of the study so it is necessary to state at what endpoint they are unblinded. The blinding process needs to be specified so that its likely success can be evaluated.

study blinding procedure
type: Class
subclass of: research activity
has curation status: Discussed
definition: A research activity that aims to ensure that study participants in an interventional research study have as little information as possible about which of two or more interventions they are to experience.

conversational analysis protocol
type: Class
subclass of: protocol
has curation status: Discussed
definition: A protocol for the analysis of conversations.

Jefferson Transcription System
type: Class
subclass of: conversational analysis protocol
has curation status: Discussed
definition: A conversational analysis protocol that represents parts and features of conversations, including pauses and non-verbal utterances using a controlled vocabulary of symbols
alternative term: Jeffersonian transcribing

beneficial process
type: Class
subclass of: process
has curation status: Discussed
definition: A process that produces a good or helpful outcome.
alternative term: benefit

individually randomised controlled trial design
type: Class
subclass of: randomised controlled trial design
has curation status: Discussed
definition: A randomised controlled trial design in which individuals are randomly allocated to intervention arms.

pragmatic randomised trial design
type: Class
subclass of: randomised controlled trial design
has curation status: Discussed
definition: A randomised controlled trial design that aims to evaluate the effectiveness of an intervention under conditions similar to those that would obtain were the intervention to be delivered in routine practice.

in remission
type: Class
subclass of: personal attribute
has curation status: Discussed
definition: A personal attribute in which the person presents fewer or lower intensity of symptoms compared to their previous symptom presentation, and the current symptoms minimally interfere with their life.

relapsed to a disorder
type: Class
subclass of: personal attribute
has curation status: Proposed
definition: A personal attribute in which the symptoms of a person suffering from a disorder have reverted from a desired level to an undesired level.

recovered
type: Class
subclass of: personal attribute
has curation status: Discussed
definition: A personal attribute in which a person who was suffering from a disorder no longer suffers from that disorder.
alternative term: cured

suffering from an addictive disorder
type: Class
subclass of: health status
has curation status: Discussed
definition: A health status in which a person is suffering from an addictive disorder.

positive self-identity
type: Class
subclass of: self-identity
has curation status: Published
definition: A self-identity that includes a positive self-appraisal

relapsed to a behaviour pattern
type: Class
subclass of: personal attribute
has curation status: Discussed
definition: A personal attribute in which the person has resumed a behaviour pattern having previously abstained from that behaviour pattern.
comment: Operationalisation should specify a threshold above which the number and timing of occurrences of tobacco use render it resumption. The operationalization also needs to specify the period over which the behaviour is being observed.

relapsed to tobacco use
type: Class
subclass of: relapsed to a behaviour pattern
has curation status: Discussed
definition: Relapsed to a behaviour pattern in which the behaviour pattern is tobacco use.
comment: This class represents relapse from any form of tobacco use to any form of tobacco use. For example, cigarette smoking to smokeless tobacco use.

lapsed to a behaviour pattern
type: Class
subclass of: personal attribute
has curation status: Discussed
definition: A personal attribute in which the person has engaged in a behaviour pattern, having previously been abstinent but then resumed abstinence.
comment: The threshold for the number and timing of occurrences of a behaviour pattern that distinguished lapse from relapse needs to be specified along with the duration of abstinence that includes the lapse.

health status
type: Class
subclass of: personal attribute
has curation status: Discussed
definition: A personal attribute that is the person's current or past state of physical or mental wellness.

mental health status
type: Class
subclass of: health status
has curation status: Discussed
definition: A health status where the medical condition is a mental health condition.

abstinence violation effect
type: Class
subclass of: bodily process
has curation status: Discussed
definition: A bodily process in which a behavioural lapse results in relapse through negative emotions attributed by the person to the lapse.

addiction development
type: Class
subclass of: bodily process
has curation status: Discussed
definition: A bodily process in which addiction strength is increased.

self-identity development
type: Class
subclass of: mental process
has curation status: Published
definition: A mental process that involves the development of some self-identity.

self-appraisal in relation to a social group
type: Class
subclass of: self-appraisal
has curation status: Discussed
definition: A self-appraisal based on values held by a social group of which the person is a member.

drug use behaviour
type: Class
subclass of: consumption behaviour
has curation status: Discussed
definition: A consumption behaviour that involves ingestion of a drug.
alternative term: drug use
comment: it is a chemical with a drug role and drug role, also defined in AddictO. So this involves any drug ingested in any manner.
comment: refer to the definition of drug in AddictO

nicotine dose obtained
type: Class
subclass of: data item
has curation status: Discussed
definition: A data item that is about the amount of nicotine that is absorbed into the body from use of a nicotine-containing product.

social grade
type: Class
subclass of: personal attribute
has curation status: Proposed
definition: unemployed and lowest grade occupations.
definition: A personal attribute that is a marker of the socio-economic position of someone aged 16 or over based on their occupation. AB: Higher and intermediate managerial, administrative and professional occupations. C1: Supervisory, clerical, and junior managerial, administrative and professional occupations C2: Skilled manual occupations. DE: Semi-skilled and unskilled manual occupations
definition source: https://www.ons.gov.uk/census/aboutcensus/censusproducts/approximatedsocialgradedata
comment: The original definition limits social grade to people aged 16 to 64 but the class defined here includes all ages 16 and above.

Government Office Region
type: Class
subclass of: within-country location
has curation status: Discussed
definition: A within country location that is one of nine geographical regions that cover the country of England: North East, North West, Yorkshire, East Midlands, West Midlands, London, South East, East of England and South West.
definition source: https://www.ons.gov.uk/methodology/geography/ukgeographies/administrativegeography/england#regions

pleasure associated with cigarette smoking
type: Class
subclass of: pleasure associated with behaviour
has curation status: Proposed
definition: Pleasure associated with a behaviour where the behaviour is cigarette smoking.
alternative term: enjoyment of smoking

disposition to enjoy cigarette smoking
type: Class
subclass of: mental disposition
has curation status: Discussed
definition: A mental disposition to experience pleasure associated with cigarette smoking.

disposition to want to stop cigarette smoking
type: Class
subclass of: mental disposition
has curation status: Discussed
definition: A mental disposition to experience a subjective want to stop smoking cigarettes.

intention to stop cigarette smoking
type: Class
subclass of: behavioural intention
has curation status: Discussed
definition: A behavioural intention to stop smoking indefinitely.

extent of interaction with cigarette smokers
type: Class
subclass of: personal attribute
has curation status: Discussed
definition: A personal attribute that is how much the person interacts with cigarette smokers.
comment: This class can be operationalised in many ways but in social network analysis often involves a sum of the number of smokers in the person's social network weighted by the importance of the relationship.

history of diagnosis of a psychiatric disorder
type: Class
subclass of: history of diagnosis of a disorder
has curation status: Discussed
definition: A history of diagnosis of a disorder in which the disorder is a psychiatric disorder.

history of diagnosis of a disorder
type: Class
subclass of: personal attribute
has curation status: Discussed
definition: A personal attribute in which the person has received a diagnosis of a disorder.

number of tobacco smoking cessation attempts in the past year
type: Class
subclass of: data item
has curation status: Discussed
definition: A data item that is about how many times the person has attempted to stop tobacco smoking in the past year.

attempting individual behaviour pattern cessation
type: Class
subclass of: personal attribute
has curation status: Discussed
definition: A personal attribute that in which the person is putting into effect an intention to achieve cessation of a behaviour pattern.
comment: This class has to be a behavioural attribute rather than, say, a process, because it involves a combination of a disposition (intention) and processes (behaviour change) that characterises a person at a given time.

attempting to stop cigarette smoking
type: Class
subclass of: personal attribute
has curation status: Discussed
definition: Attempting individual behaviour pattern cessation where the behaviour pattern is cigarette smoking.

cigarette consumption
type: Class
subclass of: data item
has curation status: Discussed
definition: A data item that is about the number of cigarettes smoked per unit of time.

alcohol consumption amount
type: Class
subclass of: personal attribute
has curation status: Discussed
definition: A personal attribute that is how much alcohol a person consumes.
alternative term: alcohol consumption
comment: This class is distinct from 'alcohol consumption' which refers only to the consumption of alcohol, not the amount of alcohol consumed.

licensed nicotine product-use
type: Class
subclass of: nicotine consumption behaviour pattern
has curation status: Discussed
definition: A nicotine consumption behaviour pattern that involves use of a licensed nicotine containing product.
alternative term: NRT use
comment: This class covers use of nicotine transdermal patches, nicotine gum, nicotine nasal spray, nicotine mouth spray, nicotine lozenge and other products that have received marketing approval by a medicines regulatory agency. Strictly, it could at some point include e-cigarettes if they were to get a licence.

strength of addiction to cigarette smoking
type: Class
subclass of: addiction strength
has curation status: Discussed
definition: Addiction strength for cigarette smoking

past-year varenicline use in a cigarette smoking cessation attempt
type: Class
subclass of: having enacted a behaviour
has curation status: Discussed
definition: Having enacted a behaviour that involves having used varenicline to aid a quit attempt in the past year.

past-year use of behavioural support in a cigarette smoking cessation attempt
type: Class
subclass of: having enacted a behaviour
has curation status: Discussed
definition: Having enacted a behaviour that that involves having used behavioural support to aid a quit attempt in the past year.

intention to stop cigarette smoking soon
type: Class
subclass of: intention to stop cigarette smoking
has curation status: Discussed
definition: Intention to stop cigarette smoking in the near future.
comment: This class cover the dimension of intention from no intention to a strong intention.

weekly spend on tobacco in UK pounds
type: Class
subclass of: data item
has curation status: Discussed
definition: A data item that is about how much money the person spends on average each week buying tobacco in UK pounds.

cigarette smoker
type: Class
subclass of: tobacco smoker
has curation status: Discussed
definition: A tobacco smoker who smokes cigarettes.

money
type: Class
subclass of: generically dependent continuant
has curation status: Discussed
definition: A generically dependent continuant that is socially constructed to functions as a medium of exchange, a unit of account and a store of value.

agitation
type: Class
subclass of: bodily process
has curation status: Discussed
definition: A bodily process that involves anxiety, irritability and a heightened level of physiological arousal.
definition source: NCIT:C79530

binge behaviour pattern
type: Class
subclass of: consumption behaviour pattern
has curation status: Discussed
definition: A consumption behaviour pattern involving repeated occurrences of binge behaviour sessions.
comment: This class is the one to use for tendencies to binge on something.

binge behaviour session
type: Class
subclass of: consumption behaviour pattern
has curation status: Discussed
definition: A consumption behaviour pattern in which the behaviour is repeated in a session to an extent that is excessive.
comment: This is a very loosely defined class that is based on judgements about what constitutes 'excessive' and a 'session' and therefore must be operationalised and defined for a given behaviour and usage. The parent is a behaviour pattern because the entity involves more than one occurrence of the behaviour. This class is restricted to consumption behaviours such as eating, smoking, drinking and taking drugs.

binge drinking behaviour pattern
type: Class
subclass of: binge behaviour pattern
has curation status: Discussed
definition: A binge behaviour pattern in which the behaviour is consumption of an alcohol beverage

binge drinking reduction
type: Class
subclass of: data item
has curation status: Discussed
definition: A data item describing whether or how far a person's binge drinking behaviour pattern has reduced in frequency.
comment: As a data item this class needs to be further specified to be able to interpret the numerical value.

binge drinking session
type: Class
subclass of: binge behaviour session
has curation status: Discussed
definition: A binge behaviour session in which the behaviour is consumption of an alcoholic beverage.

past 30-day binge drinking occurrence
type: Class
subclass of: data item
has curation status: Discussed
definition: A data item indicating whether or not a person has engaged in a binge drinking session in the past 30 days.
comment: To provide the number of binge drinking sessions use 'past 30-day binge drinking frequency'

population attribute
type: Class
subclass of: specifically dependent continuant
has curation status: Proposed
definition: An attribute that inheres in a population.

2-way statistical interaction
type: Class
subclass of: statistical interaction
has curation status: Discussed
definition: A statistical interaction between two variables.

time series analysis
type: Class
subclass of: statistical analysis
has curation status: Discussed
definition: A statistical analysis involving multiple data points arising from measures taken at repeated intervals that outputs parameter estimates describing changes over time in the data.
comment: This class includes analyses that describe changes over time in a time series and analyses that estimate associations between changes over time in one or more data sequence and others.

substance user
type: Class
subclass of: human being
has curation status: Discussed
definition: A person who engages in psychoactive substance use.
alternative term: psychoactive substance user
comment: This class includes people who use any psychoactive substance. Use is defined as a behaviour pattern and not a single episode of behaviour.

healthcare organisation
type: Class
subclass of: organisation
has curation status: Proposed
definition: An organisation that provides healthcare.

measurement
type: Class
subclass of: research activity
has curation status: Proposed
definition: A research activity whose purpose is to assign a number to an attribute of an object or event or to classify the object or event according to that attribute.

adverse treatment outcome
type: Class
subclass of: bodily harm
has curation status: Proposed
definition: Harm that results from some medical treatment.

harm
type: Class
subclass of: quality
has curation status: Proposed
definition: A quality that inheres in some independent continuant and involves a detrimental change in the bearer's condition compared with a normative or previously existing condition.

health risk
type: Class
subclass of: disease absolute risk
has curation status: Proposed
definition: A disposition of a person involving the probability of experiencing adverse health outcomes over a defined time period.

culture
type: Class
subclass of: population attribute
has curation status: Proposed
definition: A population attribute that consists of shared patterns of beliefs, evaluations, feelings, rules and behaviours that are maintained and spread among members of the population through social learning processes.
comment: Population refers to any collection of two or more people, whether in organised social groups such as teams or families or not.

personal experience
type: Class
subclass of: process
has curation status: Proposed
definition: A process that involves a person and of which the person has some subjective experience of what is occurring, either at the time or later.
comment: This class is intended to capture everything that happens to a person of which they have some awareness. It forms the parent class of adverse life event.

clinical adverse event following treatment
type: Class
subclass of: bodily process
has curation status: Proposed
definition: A bodily process involving clinical signs or symptoms, or onset, prolongation or worsening of a clinical disorder or disease.
alternative term: averse event
comment: This is not the same as an adverse reaction because there may or may not be a causal association between the treatment and the event.

intention to quit substance use
type: Class
subclass of: behavioural intention
has curation status: Proposed
definition: A behavioural intention to stop using a psychoactive substance indefinitely.

extent of social smoking
type: Class
subclass of: personal attribute
has curation status: Proposed
definition: A personal attribute of a tobacco smoker that is how much of the person's tobacco smoking takes places in the presence of other people who are smoking.

human age in years
type: Class
subclass of: data item
has curation status: Proposed
definition: A data item that is about human age and is expressed in years rounded down.
alternative term: age

guardian who smokes tobacco
type: Class
subclass of: personal attribute
has curation status: Proposed
definition: A personal attribute that is having or having had one or more guardians when young who smoke or smoked tobacco regularly.
curator note: This is set as a personal attribute because it is most practicable to construe it that way rather than the much more complex way of referring to a person's history or a personal relationship with a smoker.

laboratory facility
type: Class
subclass of: research facility
has curation status: Proposed
definition: A research facility in which systems of manufactured products control internal conditions and in which scientific or technological research, experiments, and measurement may be performed.
curator note: A new class has been defined because the ENOVO class has incompatible parentage.

research facility
type: Class
subclass of: facility
has curation status: Proposed
definition: A facility where scientific research or measurements can be undertaken.
curator note: This class refers to research facilities that are architectural structures and not ones that are mobile. This is because it comes under OMRSE's class 'facility'. ENVO has a broader class.

building
type: Class
subclass of: architectural structure
has curation status: Proposed
definition: An architectural structure with walls and a roof.

commercial building
type: Class
subclass of: building
has curation status: Proposed
definition: A building which is primarily used to facilitate the buying or selling of goods or services.

shop
type: Class
subclass of: commercial building
has curation status: Proposed
definition: A commercial building in which a business presents a selection of goods and offers to trade or sell them to customers for money or other goods.

negative self-identity
type: Class
subclass of: self-identity
has curation status: Discussed
definition: A self identity that includes a negative self-appraisal.

drug withdrawal syndrome
type: Class
subclass of: bodily disposition
has curation status: Proposed
definition: A bodily disposition to undergo pathological processes characterized by physiological or psychological dysfunction that exists in an organism because of homeostatic disruption resulting from the cessation or reduction of repeated drug exposure.
comment: This class refers to 'syndrome' as a disposition and is technically a 'disease' as defined by OGMS rather than a collection of signs and symptoms. 'Disease' is not mentioned in the definition because the term carries other meanings for people than the one strictly applied from OGMS.

nicotine withdrawal syndrome
type: Class
subclass of: drug withdrawal syndrome
has curation status: Proposed
definition: A drug withdrawal syndrome that results from cessation or reduction of nicotine consumption.
alternative term: Cigarette withdrawal
comment: Typical features of the nicotine withdrawal syndrome are increased appetite, irritability, depressed mood, increased anxiety, restlessness and difficult concentrating and craving for the habitual nicotine delivery system. These typically last for up to 4 weeks but increased appetite lasts longer. Craving is sometimes considered as separate.

epidemic
type: Class
subclass of: process
has curation status: Proposed
definition: A process involving widespread occurrence of a disease or disorder in a population.
comment: This class is intended to be used broadly. Classes whose definitions are used by WHO or other legal entities would be subclasses.

opioid use disorder epidemic
type: Class
subclass of: epidemic
has curation status: Proposed
definition: Epidemic of opioid use disorder

alcohol withdrawal syndrome
type: Class
subclass of: drug withdrawal syndrome
has curation status: Proposed
definition: A drug withdrawal syndrome that results from cessation or reduction of alcohol consumption.

cannabis withdrawal syndrome
type: Class
subclass of: drug withdrawal syndrome
has curation status: Proposed
definition: A drug withdrawal syndrome that results from cessation or reduction of cannabis consumption.

opioid withdrawal symptom
type: Class
subclass of: drug withdrawal syndrome
has curation status: Proposed
definition: A drug withdrawal syndrome that results from cessation or reduction of consumption of an opioid drug.

personal disposition
type: Class
subclass of: disposition
has curation status: Proposed
definition: A disposition that inheres in a person.

personal life attribute
type: Class
subclass of: process attribute
has curation status: Proposed
definition: A process attribute that is an attribute of a life process.

personal quality
type: Class
subclass of: quality
has curation status: Proposed
definition: A quality that inheres in a person

social grade AB
type: Class
subclass of: social grade
has curation status: Proposed
definition: A social grade where the person's occupation is higher and intermediate professional or managerial.

social grade C1
type: Class
subclass of: social grade
has curation status: Proposed
definition: A social grade where the person's occupation is supervisory, clerical, or junior managerial or administrative or professional.

social grade C2
type: Class
subclass of: social grade
has curation status: Proposed
definition: A social grade where the person's occupation is as a skilled manual worker.

social grade D
type: Class
subclass of: social grade
has curation status: Proposed
definition: A social grade where the person's occupation is as a semi-skilled or unskilled manual worker.

social grade E
type: Class
subclass of: social grade
has curation status: Proposed
definition: A social grade where the person's primary income is from state benefit or they are unemployed or in unstable, low paid, unskilled employment.

past or current diagnosis of mental health disorder
type: Class
subclass of: mental health status
has curation status: Proposed
definition: A mental health status in which the person has ever been diagnosed as suffering from a mental health disorder.

AUDIT-C score
type: Class
subclass of: data item
has curation status: Proposed
definition: A data item that is about the quantity and frequency of alcohol consumption of a person.
comment: Involves three question scored from 0 to 4 resulting in a score from 0 to 12, with a score of 5 to 7 meaning 'increasing risk', 8 to 10 meaning 'higher risk' and '11 to 12' meaning possible dependence.

nicotine consumption behaviour pattern
type: Class
subclass of: substance use behaviour pattern
has curation status: Discussed
definition: A substance use behaviour pattern in which the psychoactive substance is nicotine.

inhaling consumption behaviour pattern
type: Class
subclass of: consumption behaviour pattern
has curation status: Discussed
definition: A consumption behaviour pattern that involves breathing in a material through the nose or mouth.

social housing tenure
type: Class
subclass of: rental housing tenure
has curation status: Proposed
definition: A rental housing tenure in which the person's main residence is a property rented from a housing association or a local authority.

high proportion of smoking enacted with other smokers
type: Class
subclass of: extent of social smoking
has curation status: Proposed
definition: Extent of social smoking in which all or almost all smoking is enacted with other smokers.
curator note: Although this refers to a behaviour, it is in the 'human being' subontology because it characterises a person with reference to their behaviour.

low proportion of smoking enacted with other smokers
type: Class
subclass of: extent of social smoking
has curation status: Proposed
definition: Extent of social smoking in which not very much of it or none of it is enacted with other smokers.
comment: Because the proportion that qualifies as 'low' needs to be operationalised.

moderate proportion of smoking enacted with other smokers
type: Class
subclass of: extent of social smoking
has curation status: Proposed
definition: Extent of social smoking in which most, or some of it, but not all or almost all of it, is enacted with other smokers.
comment: Because the proportion that qualifies as 'moderate' needs to be operationalised.

housing tenure
type: Class
subclass of: personal attribute
has curation status: Proposed
definition: A personal attribute that is the person's ownership or rental status of the property in which they mainly reside.

free housing tenure
type: Class
subclass of: housing tenure
has curation status: Proposed
definition: A housing tenure in which the person's main residence is provided to them, their intimate partner or a close family member free of charge by the owner.
comment: This includes people who receive accommodation through their work. It also includes 'squatting' on a long-term basis without the owner's permission.

owner-occupier housing tenure
type: Class
subclass of: housing tenure
has curation status: Proposed
definition: A housing tenure in which the person's main residence is a property that they, their intimate partner or close family member at least partially own.
comment: This class includes properties with and without mortgages and ones in which they own part of the property. This includes leaseholders. It includes parents who are living with children who own the property and children living with parents who own the property.

rental housing tenure
type: Class
subclass of: housing tenure
has curation status: Proposed
definition: A housing tenure in which the person's main residence is rented by them or an intimate partner or a close family member from another person or organisation.
comment: This class includes all cases where the person is paying rent and has no ownership of the property. This includes people who are renting a room in an apartment or house, whoever owns the apartment or house. It includes people who are living in residential institutions for which they are paying.

no-main-residence housing tenure
type: Class
subclass of: housing tenure
has curation status: Proposed
definition: A housing tenure in which the person does not have a fixed main residence.
comment: This class includes people who are designated as 'homeless' or who are between main residences.

owned outright housing tenure
type: Class
subclass of: owner-occupier housing tenure
has curation status: Proposed
definition: An owner-occupier housing tenure in which the property is fully owned by the person or a member of their immediate family.

owned with mortgage housing tenure
type: Class
subclass of: owner-occupier housing tenure
has curation status: Proposed
definition: An owner-occupier housing tenure in which the property is subject to a bank loan or mortgage.

private rental housing tenure
type: Class
subclass of: rental housing tenure
has curation status: Proposed
definition: A rental housing tenure in which the owner of the property is a person, group of people or an organisation that is neither governmental nor acting on behalf of a governmental organisation.

disposition not to enjoy cigarette smoking at all
type: Class
subclass of: disposition to enjoy cigarette smoking
has curation status: Proposed
definition: A disposition not to experience any enjoyment from cigarette smoking or to dislike it.

disposition to enjoy cigarette smoking a little
type: Class
subclass of: disposition to enjoy cigarette smoking
has curation status: Proposed
definition: A disposition to enjoy cigarette smoking to a small degree.

disposition to enjoy cigarette smoking somewhat
type: Class
subclass of: disposition to enjoy cigarette smoking
has curation status: Proposed
definition: A disposition to enjoy cigarette smoking to a moderate degree.

disposition to enjoy cigarette smoking very much
type: Class
subclass of: disposition to enjoy cigarette smoking
has curation status: Proposed
definition: A disposition to enjoy cigarette smoking to a high degree.

intention to stop cigarette smoking soon to some degree
type: Class
subclass of: intention to stop cigarette smoking soon
has curation status: Proposed
definition: Intention to stop cigarette smoking soon that involves at least some positive intention.
comment: This class involves at least some positive intention.

disposition to want to stop cigarette smoking to some degree
type: Class
subclass of: disposition to want to stop cigarette smoking
has curation status: Proposed
definition: A disposition to want to stop smoking that involves wanting to stop smoking at least sometimes.

financial potential competing interest
type: Class
subclass of: potential competing interest
has curation status: Proposed
definition: A potential competing interest involving a potential financial gain or loss to the person or an organisation or person with which they have a relationship.
comment: This includes: 1) ownership of stocks or shares, 2) employment in an organisation, 3) providing paid consultancy to an organisation, 4) being a director of a company, 5) receiving any kind of funding or tangible benefit (e.g. research grant, travel funding, hospitality, gift) from an organisation, 6) ownership of, or pending application for, a patent, and 7) seeking funding from an organisation, that may be affected by the enactment of the professional role. It also includes all of the above that relate to an intimate partner. Organisation includes commercial organisation, government agency, and charity.

non-financial potential competing interest
type: Class
subclass of: potential competing interest
has curation status: Proposed
definition: A potential competing interest involving gain or loss to the person or an organisation or person with which they have a relationship in terms of reputation, advancement, or support for personal values.

commercial organisation
type: Class
subclass of: organisation
has curation status: Proposed
definition: An organisation whose main goal is making money by selling products or services.

Nicotine-product company
type: Class
subclass of: commercial organisation
has curation status: Proposed
definition: A commercial organisation that is engaged in the manufacture, preparation for sale, shipment, advertisement, or distribution of a nicotine-containing product or part of such a product, or is at least partly owned by such an organisation.

pharmaceutical company
type: Class
subclass of: commercial organisation
has curation status: Proposed
definition: A commercial organisation that is engaged in the manufacture, preparation for sale, shipment, advertisement, or distribution of a pharmaceutical product or part of such a product, or is at least partly owned by such an organisation.

e-cigarette company
type: Class
subclass of: commercial organisation
has curation status: Proposed
definition: A commercial organisation that is engaged in the manufacture, preparation for sale, shipment, advertisement, or distribution of an e-cigarette or part of such a product, or is at least partly owned by such an organisation.

health-improvement organisation
type: Class
subclass of: organisation
has curation status: Proposed
definition: An organisation that has as a function the production, distribution, or provision of goods or services intended to improve health or reduce ill-health.

recreational organisation
type: Class
subclass of: organisation
has curation status: Proposed
definition: An organisation that has as a function the production, distribution, or provision of goods or services intended for recreational use by consumers.

behaviour change intervention scenario
type: Class
subclass of: planned process
has curation status: Published
definition: A planned process in which a BCI is applied in a given context, including BCI engagement and outcome behaviour.
alternative term: BCI scenario

behaviour change intervention context
type: Class
subclass of: object aggregate
example of usage: Includes as part BCI population and BCI setting. Use of the word ‘may’ conveys a non-zero probability given available information.
has curation status: Published
definition: An aggregate of entities that are not dependent on the intervention but may influence the effect of a BCI on its outcome behaviour.
alternative term: BCI context

behaviour change intervention mechanism of action
type: Class
subclass of: process
has curation status: Published
definition: A process that is causally active in the relationship between a BCI scenario and its outcome behaviour.
alternative term: BCI MOA

behavioural intention
type: Class
subclass of: mental disposition
example of usage: "Behavioural Intention" in the Technology Acceptance Model
example of usage: "Behavioural intention" in the Ecological Model for Preventing Type 2 Diabetes
example of usage: "Behavioural intention" in the Six-staged model of communication effects
example of usage: "Commitment to a plan of action" in the Health Promotion Model
example of usage: "Commitment" in the Goal Setting Theory
example of usage: "Decisions tier" in the Theory of Triadic Influence
example of usage: "Enactment" in the AIDS Risk Reduction Model"
example of usage: "General behavioural intentions" in the Theory of Interpersonal Behavior
example of usage: "Goal intention" in the Action Theory Model of Consumption
example of usage: "Health intention" in the Systems Model of Behaviour Change
example of usage: "Intending" in the Reflective Impulsive Model
example of usage: "Intention to change" in the Social Ecological Model of Behaviour Change
example of usage: "Intention" in the Health Action Process Approach
example of usage: "Intention" in the Integrative Model of Behavioural Prediction
example of usage: "Intention" in the Needs-Opportunity-Abilities Model
example of usage: "Intention" in the Theory of Planned Behaviour
example of usage: "Intentions" in the Temporal Self-Regulation Theory
example of usage: "Intentions" in the Transcontextual Model of Motivation
example of usage: "Motivation / intention state" in the I-Change Model
example of usage: "Motivational phase" in the Health Action Process Approach
example of usage: "Plans" in the PRIME Theory
example of usage: "Preparation" in the Six-Staged Model of Communication Effects
example of usage: "Specific behavioural intentions" in the Theory of Interpersonal Behaviour
example of usage: "Validation" in the Six-Staged Model of Communication Effects
example of usage: "We-Intentions" in the Social Influence Model
example of usage: "Implementation intentions" in the Action Theory Model of Consumption
has curation status: External
has curation status: Published
definition: A <mental disposition> to commit to enact or not enact a behaviour
definition: A <mental disposition> to commit to enact or not enact a behaviour.
comment: The term ‘plan’ can sometimes be used to refer to intention and sometimes for instructional plans.

personal role
type: Class
subclass of: role
subclass of: chemical realizable
has curation status: External
has curation status: Published
definition: A <role> that inheres in a human being by virtue of their social and institutional circumstances.
definition: A role that inheres in a human being by virtue of their social and institutional circumstances.
definition: A role that inheres in a person
comment: A role can be assigned without being realised. A person realises a role by doing something.

pleasure associated with behaviour
type: Class
subclass of: pleasure (emotion)
has curation status: External
has curation status: Published
definition: <Pleasure emotion> that is experienced as a result of engaging in a behaviour.
definition: <Pleasure> that is experienced as a result of engaging in a behaviour.
alternative term: Enjoyment of behaviour

behaviour change intervention delivery
type: Class
subclass of: intervention delivery
has curation status: Published
definition: An intervention delivery in which the intervention is a behaviour change intervention.
alternative term: BCI delivery

behaviour change intervention source
type: Class
subclass of: chemical realizable
example of usage: This includes individual people, groups of people, and organisations.
has curation status: Published
definition: A role played by a person, population or organisation that provides a BCI.
alternative term: BCI source

human age
type: Class
subclass of: personal attribute
has curation status: External
has curation status: Published
definition: A personal attribute that is a time quality inhering in a person by virtue of how long since the person was born.

sexual orientation
type: Class
subclass of: personal attribute
has curation status: Published
definition: A personal attribute that is the pattern of a person's emotional, romantic and/or sexual attractions.

bisexual
type: Class
subclass of: sexual orientation
has curation status: Published
definition: A sexual orientation of an individual who experiences sexual attraction to members of more than one sex.

homeless person
type: Class
subclass of: human being
has curation status: Published
definition: A person who does not own a residential facility and does not have an agreement with a residential facility owner that would enable them to live in a residential facility.
alternative term: person experiencing homelessness

inpatient role
type: Class
subclass of: patient role
has curation status: Published
definition: A patient role which inheres in a person and is realized by being under the care of a physician or health care provider and being admitted to a hospital or equivalent facility.

outpatient role
type: Class
subclass of: patient role
has curation status: Published
definition: A patient role which inheres in a person and is realized by coming to a healthcare facility for diagnosis or treatment but not being admitted for an overnight stay.

biological mother population statistic
type: Class
subclass of: biological parent population statistic
has curation status: Published
definition: A population statistic about biological mother.

biological parent population statistic
type: Class
subclass of: parent population statistic
has curation status: Published
definition: A population statistic about biological parent.

family member population statistic
type: Class
subclass of: population statistic
has curation status: Published
definition: A population statistic about family member.

parent population statistic
type: Class
subclass of: family member population statistic
has curation status: Published
definition: A population statistic about parent.

within-country location
type: Class
subclass of: geographic location
example of usage: City
example of usage: New York
example of usage: Rotterdam
example of usage: State
example of usage: Town
example of usage: Region
has curation status: External
has curation status: Published
definition: A geographical location within a country where the intervention takes place.
definition: A geographical location within a country.

hospital outpatient clinic facility
type: Class
subclass of: hospital facility
has curation status: External
has curation status: Published
definition: A hospital facility to treat patients without them staying overnight, often after a hospital visit.
alternative term: outpatient clinic

behaviour change intervention study investigator
type: Class
subclass of: chemical realizable
example of usage: What counts as substantively is subject to judgement. The level and nature of the contribution can be defined using the CReDiT taxonomy (https://casrai.org/credit/).
has curation status: Published
definition: A role played by a person that contributes substantively to production or reporting of a BCI evaluation study.
alternative term: BCI study investigator

population behaviour
type: Class
subclass of: process aggregate
subclass of: process
has curation status: External
has curation status: Published
definition: An aggregate of individual human behaviours of members of a population.
alternative term: human behaviour

individual human behaviour
type: Class
subclass of: individual human activity
subclass of: bodily process
example of usage: Also referred to in definitions as human behaviour or just behaviour.
example of usage: walks for 15 mins/day, never eats meat, attends school daily
has curation status: External
has curation status: Published
definition: A <bodily process> of a human that involves co-ordinated contraction of striated muscles controlled by the brain.
definition: A bodily process of a human that involves co-ordinated contraction of striated muscles controlled by the brain.
definition: Individual human activity that involves co-ordinated contraction of striated muscles controlled by the brain.
alternative term: human behaviour
comment: it is concerned with moving skeletal parts to which it is usually attached.' (https://www.collinsdictionary.com/dictionary/english/striped-muscle)
comment: Striated muscles referred to in the definition do not ordinarily involve cardiac muscles. Behaviours are usually in response to an internal or external stimuli. Every behaviour is associated with mental processes, but not every mental process is associated with behaviour. For instance, a verbal communication behaviour will involve mental processes to produce speech. However, mental processes associated with listening can occur without a person performing a behaviour. 'behaviours' can involve a series of activities (e.g., more granular behaviours). 'A 'striated muscle' can defined as 'a type of contractile tissue that is marked by transverse striations

object-using behaviour
type: Class
subclass of: material entity-related behaviour
example of usage: Shooting, Writing, Using a weapon, Using public transport, Taking a bus, Sailing, Typing, Collecting, Drying, Ironing, Painting, Drawing
has curation status: External
has curation status: Published
definition: A material entity-related behaviour that uses a non-living object.
definition: A material-entity related behaviour that uses a non-living object.
comment: Non-living objects can include engineered artifacts, grain of sand and/or molecules.

consumption behaviour
type: Class
subclass of: material entity-related behaviour
has curation status: External
has curation status: Published
definition: A material entity-related behaviour that involves ingesting material into the body.

individual human behaviour pattern
type: Class
subclass of: uniform process aggregate
has curation status: External
has curation status: Published
definition: A uniform process aggregate whose member parts are behaviours of the same type and in the same person.
alternative term: behaviour pattern
curator note: - For any x and y in P where x does not equal y, if x occupies_spatiotemporal_region s, then y occupies_spatiotemporal_region t and s does not equal t
curator note: - s is instance_of human being
curator note: - For any pi in P, pi is instance_of X
curator note: - For any pi in P, s is participant_in pi
curator note: - X is subtype_of behaviour
curator note: - P is the set {p1, ... pn} of process aggregate member parts of b
curator note: b is a behaviour pattern means: - b is instance_of uniform process aggregate
comment: The term 'pattern' is used to refer to several processes (individual human behaviours) of the same type being repeated overtime. This class is intended to include behaviours that can usefully be characterised in terms of frequency and pattern of enactment with a temporal start and end of the series. This means that the series can be terminated (e.g. stopping smoking), interrupted (e.g. abstaining from alcohol consumption for a month), and changed in frequency (e.g. cutting down on snacks).

tobacco use behaviour pattern
type: Class
subclass of: substance use behaviour pattern
has curation status: External
has curation status: Published
definition: A substance use behaviour pattern that involves tobacco use.
alternative term: tobacco use

tobacco smoking behaviour
type: Class
subclass of: tobacco use behaviour
has curation status: External
has curation status: Published
definition: A tobacco use behaviour that involves setting light to a combustible tobacco product and ingesting the tobacco smoke that is produced.
alternative term: combustible tobacco use
alternative term: smoking

tobacco smoking behaviour pattern
type: Class
subclass of: tobacco use behaviour pattern
has curation status: External
has curation status: Published
definition: A tobacco use behaviour pattern that involves tobacco smoking behaviour.

cigarette smoking behaviour
type: Class
subclass of: tobacco smoking behaviour
has curation status: External
has curation status: Published
definition: A tobacco smoking behaviour that involves setting light to one end of a cigarette, putting the other end to the lips and sucking in order to ingest cigarette smoke.
alternative term: tobacco smoking

cigarette smoking behaviour pattern
type: Class
subclass of: tobacco smoking behaviour pattern
has curation status: External
has curation status: Published
definition: A tobacco smoking behaviour pattern that indicates current use of cigarettes.
definition: A tobacco smoking behaviour pattern that involves cigarette smoking behaviour.
alternative term: cigarette smoking

process aggregate
type: Class
subclass of: occurrent
has curation status: Published
definition: An occurrent consisting exactly of a plurality of processes that are process_aggregate_member_parts_of that occurrent for all times at which it exists.
curator note: Process aggregate extends BFO in the same way that object aggregate extends its coverage of material entities. It is required to be able to classify occurrents such as behaviour patterns that are repeated occurrences of classes of process that have properties such as average frequency of occurrence (not to be confused with frequency as a process profile) and temporal patterning of occurrences.

substance use behaviour
type: Class
subclass of: consumption behaviour
has curation status: External
has curation status: Published
definition: A consumption behaviour that involves ingesting a psychoactive substance into the body.
alternative term: psychoactive substance use
alternative term: substance use
comment: Substance use behaviour is not equated with substance abuse.

tobacco use behaviour
type: Class
subclass of: substance use behaviour
has curation status: External
has curation status: Published
definition: A substance use behaviour that involves ingesting constituents of a tobacco-containing product.
alternative term: tobacco consumption
alternative term: tobacco use

intervention
type: Class
subclass of: planned process
example of usage: Examples of interventions are putting health warnings on cigarette packets, providing free stop smoking services and banning smoking in public places.
has curation status: External
has curation status: Published
definition: A planned process that has the aim of influencing an outcome.
definition: A process that is intended to change something in a population
definition source: Defined in the 'eagle-I resource ontology' as "A planned process used to influence one or more factors in a research study, and the independent variable in an interventional study wherein the influence is measured or evaluated.". Defined in the NCIT as "An activity that produces an effect, or that is intended to alter the course of a disease in a patient or population. This is a general term that encompasses the medical, social, behavioral, and environmental acts that can have preventive, therapeutic, or palliative effects." See also PICO
curator note: each Behaviour change intervention can be divided up into two complementary aspects, namely Behaviour change intervention content and Behaviour change intervention delivery. "
curator note: See behaviour change intervention in BCIO, this should be a proper generalisation of that. Last seen definition as "A process involving provision of products, services, activities, or fiscal or environmental measures that are intended to affect behaviour

individual human activity
type: Class
subclass of: process
has curation status: External
has curation status: Published
definition: A process that is produced by a person.

human population
type: Class
subclass of: object aggregate
has curation status: External
has curation status: Published
definition: An aggregate of human beings.
definition: An object aggregate that consists of two or more people.
definition source: Population in OBI is defined as "A population is a collection of individuals from the same taxonomic class living, counted or sampled at a particular site or in a particular area". See also PICO ontology
curator note: By the proposed definition we should update the name to 'human population'. Note that the BCIO 'population' ontology only defines population attributes rather than populations themselves. BCI population defined as "That part of a Behaviour change intervention context that consists of the aggregate of people whose behaviour an intervention is intended to change. "

human behaviour
type: Class
subclass of: process
has curation status: External
has curation status: Published
definition: A process that is an individual human behaviour or a population behaviour.
definition: Individual human behaviour or population behaviour.

process attribute
type: Class
subclass of: process profile
example of usage: This is intended to provide a user-friendly way of representing the way in which processes are manifest. This is somewhat similar to, but not the same as, the class 'specifically dependent continuant' in Basic Formal Ontology which provides a way of representing features of material entities such as age and size. It is formally equivalent to process profile in Basic Formal Ontology.
has curation status: External
has curation status: Published
definition: A process profile that is an attribute of a process.

intervention delivery
type: Class
subclass of: planned process
has curation status: Published
definition: A planned process by which intervention content is delivered.

consumption behaviour pattern
type: Class
subclass of: individual human behaviour pattern
has curation status: External
has curation status: Published
definition: An individual human behaviour pattern that involves consumption behaviour.

substance use behaviour pattern
type: Class
subclass of: consumption behaviour pattern
has curation status: External
has curation status: Published
definition: A consumption behaviour pattern that involves substance use behaviour.
alternative term: substance use

uniform process aggregate
type: Class
subclass of: process aggregate
has curation status: Published
definition: A process aggregate whose member parts are of the same type.
curator note: u is a uniform process aggregate means: • u instance_of process aggregate • P is the set {p1,…pn} of process aggregate member parts of u • X is some descendant of process • Each of {p1,…pn} in P is instance_of X

personal attribute
type: Class
subclass of: specifically dependent continuant
has curation status: External
has curation status: Published
definition: A specifically dependent continuant that inheres in a person.
curator note: The BCIO population ontology individuals branch defines many personal attributes
comment: Attributes included under this header are age, immigration, social and economic conditions.
comment: Includes everything that can be said about a person: the most general class under which all other qualities, dispositions, roles etc belong.

subjective want
type: Class
subclass of: subjective affective feeling
example of usage: "Value from worth" in the Regulatory Fit Theory
has curation status: External
has curation status: Published
definition: A <subjective affective feeling> that is an attraction to an imagined scenario involving anticipated pleasure or satisfaction.

prescribing behaviour
type: Class
subclass of: providing healthcare
has curation status: External
has curation status: Published
definition: Providing healthcare that involves advising and authorising the use of a treatment to improve or maintain another person's health or wellbeing.

alcohol consumption
type: Class
subclass of: substance use behaviour
has curation status: External
has curation status: Published
definition: A substance use behaviour that involves drinking an alcohol-containing product.
alternative term: alcohol use

e-cigarette use
type: Class
subclass of: electronic vaping device use
has curation status: External
has curation status: Published
definition: Inhaling consumption that involves using an e-cigarette.
alternative term: vaping
comment: E-cigarettes do not necessarily have to include nicotine but can involve inhaling flavourings or other chemicals.

electronic vaping device use
type: Class
subclass of: vaping device use
has curation status: Published
definition: Inhaling consumption that involves the use of an electronic vaping device.

vaping device use
type: Class
subclass of: inhaling consumption
has curation status: Published
definition: Inhaling consumption that involves using a device to consume an aerosol.

inhaling consumption
type: Class
subclass of: consumption behaviour
has curation status: Published
definition: A consumption behaviour that involves breathing in a material through the nose or mouth.

providing healthcare
type: Class
subclass of: health-related behaviour
has curation status: Published
definition: A health-related behaviour that involves assessing, monitoring, improving or maintaining an aspect of another person’s health.

health-related behaviour
type: Class
subclass of: individual human behaviour
has curation status: Published
definition: An individual human behaviour that relates to health of oneself or others.

material entity-related behaviour
type: Class
subclass of: individual human behaviour
has curation status: Published
definition: An individual human behaviour that relates to a material entity.

abstinence duration
type: Class
subclass of: one-dimensional temporal region
has curation status: Published
definition: A temporal interval during which a person is abstinent from a behaviour.

abstinence from a behaviour
type: Class
subclass of: personal attribute
has curation status: External
has curation status: Published
definition: A personal attribute in which a person does not engage in a behaviour during a time period.

having enacted a behaviour
type: Class
subclass of: personal history part
has curation status: Discussed
has curation status: Published
definition: A personal history part that includes previously performing a behaviour.

personal history part
type: Class
subclass of: process
has curation status: External
has curation status: Published
definition: A process that is part of a personal history.

research study sample
type: Class
subclass of: human population
has curation status: Published
definition: A population whose behaviour is studied in a research study.

population statistic
type: Class
subclass of: data item
example of usage: Percentage of highly educated individuals in a population. Mean age in a population.
has curation status: Proposed
definition: A data item that is about the number or extent of something in a population.

entity
type: Class
BFO OWL specification label: entity
BFO CLIF specification label: Entity
editor preferred label: entity
example of usage: Julius Caesar
example of usage: Verdi’s Requiem
example of usage: the Second World War
example of usage: your body mass index
definition: An entity is anything that exists or has existed or will exist.
editor note: BFO 2 Reference: In all areas of empirical inquiry we encounter general terms of two sorts. First are general terms which refer to universals or types:animaltuberculosissurgical procedurediseaseSecond, are general terms used to refer to groups of entities which instantiate a given universal but do not correspond to the extension of any subuniversal of that universal because there is nothing intrinsic to the entities in question by virtue of which they – and only they – are counted as belonging to the given group. Examples are: animal purchased by the Emperortuberculosis diagnosed on a Wednesdaysurgical procedure performed on a patient from Stockholmperson identified as candidate for clinical trial #2056-555person who is signatory of Form 656-PPVpainting by Leonardo da VinciSuch terms, which represent what are called ‘specializations’ in [81
editor note: Entity doesn't have a closure axiom because the subclasses don't necessarily exhaust all possibilites. For example Werner Ceusters 'portions of reality' include 4 sorts, entities (as BFO construes them), universals, configurations, and relations. It is an open question as to whether entities as construed in BFO will at some point also include these other portions of reality. See, for example, 'How to track absolutely everything' at http://www.referent-tracking.com/_RTU/papers/CeustersICbookRevised.pdf
imported from: bfo.owl
imported from: dron.owl
imported from: envo.owl
imported from: iao.owl
imported from: ico.owl
imported from: mondo.owl
imported from: oae.owl
imported from: obi.owl
imported from: obib.owl
imported from: ogms.owl
imported from: omrse.owl
elucidation: An entity is anything that exists or has existed or will exist. (axiom label in BFO2 Reference: [001-001])
database_cross_reference: https://www.wikidata.org/wiki/Q35120
alternate name: entities
derived from: entitātem @la

Axiom
annotated source: entity
annotated property: editor note
annotated target: Entity doesn't have a closure axiom because the subclasses don't necessarily exhaust all possibilites. For example Werner Ceusters 'portions of reality' include 4 sorts, entities (as BFO construes them), universals, configurations, and relations. It is an open question as to whether entities as construed in BFO will at some point also include these other portions of reality. See, for example, 'How to track absolutely everything' at http://www.referent-tracking.com/_RTU/papers/CeustersICbookRevised.pdf
IAO_0010000: http://purl.obolibrary.org/obo/bfo/axiom/0000004
comment: per discussion with Barry Smith

Axiom
annotated source: entity
annotated property: elucidation
annotated target: An entity is anything that exists or has existed or will exist. (axiom label in BFO2 Reference: [001-001])
IAO_0010000: http://purl.obolibrary.org/obo/bfo/axiom/001-001

continuant
type: Class
subclass of: entity
BFO OWL specification label: continuant
BFO CLIF specification label: Continuant
editor preferred label: continuant
definition: An entity that exists in full at any time in which it exists at all, persists through time while maintaining its identity and has no temporal parts.
editor note: BFO 2 Reference: Continuant entities are entities which can be sliced to yield parts only along the spatial dimension, yielding for example the parts of your table which we call its legs, its top, its nails. ‘My desk stretches from the window to the door. It has spatial parts, and can be sliced (in space) in two. With respect to time, however, a thing is a continuant.’ [60, p. 240
editor note: Continuant doesn't have a closure axiom because the subclasses don't necessarily exhaust all possibilites. For example, in an expansion involving bringing in some of Ceuster's other portions of reality, questions are raised as to whether universals are continuants
imported from: bfo.owl
imported from: dron.owl
imported from: envo.owl
imported from: iao.owl
imported from: oae.owl
imported from: obi.owl
imported from: obib.owl
imported from: ogms.owl
imported from: omrse.owl
imported from: pato.owl
imported from: ro.owl
elucidation: A continuant is an entity that persists, endures, or continues to exist through time while maintaining its identity. (axiom label in BFO2 Reference: [008-002])
has associated axiom(nl): if b is a continuant and if, for some t, c has_continuant_part b at t, then c is a continuant. (axiom label in BFO2 Reference: [126-001])
has associated axiom(nl): if b is a continuant and if, for some t, cis continuant_part of b at t, then c is a continuant. (axiom label in BFO2 Reference: [009-002])
has associated axiom(nl): if b is a material entity, then there is some temporal interval (referred to below as a one-dimensional temporal region) during which b exists. (axiom label in BFO2 Reference: [011-002])
has associated axiom(fol): (forall (x y) (if (and (Continuant x) (exists (t) (continuantPartOfAt y x t))) (Continuant y))) // axiom label in BFO2 CLIF: [009-002]
has associated axiom(fol): (forall (x y) (if (and (Continuant x) (exists (t) (hasContinuantPartOfAt y x t))) (Continuant y))) // axiom label in BFO2 CLIF: [126-001]
has associated axiom(fol): (forall (x) (if (Continuant x) (Entity x))) // axiom label in BFO2 CLIF: [008-002]
has associated axiom(fol): (forall (x) (if (Material Entity x) (exists (t) (and (TemporalRegion t) (existsAt x t))))) // axiom label in BFO2 CLIF: [011-002]
UNEP ignore: true

Axiom
annotated source: continuant
annotated property: editor note
annotated target: Continuant doesn't have a closure axiom because the subclasses don't necessarily exhaust all possibilites. For example, in an expansion involving bringing in some of Ceuster's other portions of reality, questions are raised as to whether universals are continuants
IAO_0010000: http://purl.obolibrary.org/obo/bfo/axiom/0000007

Axiom
annotated source: continuant
annotated property: elucidation
annotated target: A continuant is an entity that persists, endures, or continues to exist through time while maintaining its identity. (axiom label in BFO2 Reference: [008-002])
IAO_0010000: http://purl.obolibrary.org/obo/bfo/axiom/008-002

Axiom
annotated source: continuant
annotated property: has associated axiom(nl)
annotated target: if b is a continuant and if, for some t, c has_continuant_part b at t, then c is a continuant. (axiom label in BFO2 Reference: [126-001])
IAO_0010000: http://purl.obolibrary.org/obo/bfo/axiom/126-001

Axiom
annotated source: continuant
annotated property: has associated axiom(nl)
annotated target: if b is a continuant and if, for some t, cis continuant_part of b at t, then c is a continuant. (axiom label in BFO2 Reference: [009-002])
IAO_0010000: http://purl.obolibrary.org/obo/bfo/axiom/009-002

Axiom
annotated source: continuant
annotated property: has associated axiom(nl)
annotated target: if b is a material entity, then there is some temporal interval (referred to below as a one-dimensional temporal region) during which b exists. (axiom label in BFO2 Reference: [011-002])
IAO_0010000: http://purl.obolibrary.org/obo/bfo/axiom/011-002

Axiom
annotated source: continuant
annotated property: has associated axiom(fol)
annotated target: (forall (x y) (if (and (Continuant x) (exists (t) (continuantPartOfAt y x t))) (Continuant y))) // axiom label in BFO2 CLIF: [009-002]
IAO_0010000: http://purl.obolibrary.org/obo/bfo/axiom/009-002

Axiom
annotated source: continuant
annotated property: has associated axiom(fol)
annotated target: (forall (x y) (if (and (Continuant x) (exists (t) (hasContinuantPartOfAt y x t))) (Continuant y))) // axiom label in BFO2 CLIF: [126-001]
IAO_0010000: http://purl.obolibrary.org/obo/bfo/axiom/126-001

Axiom
annotated source: continuant
annotated property: has associated axiom(fol)
annotated target: (forall (x) (if (Continuant x) (Entity x))) // axiom label in BFO2 CLIF: [008-002]
IAO_0010000: http://purl.obolibrary.org/obo/bfo/axiom/008-002

Axiom
annotated source: continuant
annotated property: has associated axiom(fol)
annotated target: (forall (x) (if (Material Entity x) (exists (t) (and (TemporalRegion t) (existsAt x t))))) // axiom label in BFO2 CLIF: [011-002]
IAO_0010000: http://purl.obolibrary.org/obo/bfo/axiom/011-002

occurrent
type: Class
subclass of: entity
BFO OWL specification label: occurrent
BFO CLIF specification label: Occurrent
definition: An entity that has temporal parts and that happens, unfolds or develops through time.
editor note: BFO 2 Reference: every occurrent that is not a temporal or spatiotemporal region is s-dependent on some independent continuant that is not a spatial region
editor note: BFO 2 Reference: s-dependence obtains between every process and its participants in the sense that, as a matter of necessity, this process could not have existed unless these or those participants existed also. A process may have a succession of participants at different phases of its unfolding. Thus there may be different players on the field at different times during the course of a football game; but the process which is the entire game s-depends_on all of these players nonetheless. Some temporal parts of this process will s-depend_on on only some of the players.
editor note: Occurrent doesn't have a closure axiom because the subclasses don't necessarily exhaust all possibilites. An example would be the sum of a process and the process boundary of another process.
editor note: Simons uses different terminology for relations of occurrents to regions: Denote the spatio-temporal location of a given occurrent e by 'spn[e]' and call this region its span. We may say an occurrent is at its span, in any larger region, and covers any smaller region. Now suppose we have fixed a frame of reference so that we can speak not merely of spatio-temporal but also of spatial regions (places) and temporal regions (times). The spread of an occurrent, (relative to a frame of reference) is the space it exactly occupies, and its spell is likewise the time it exactly occupies. We write 'spr[e]' and `spl[e]' respectively for the spread and spell of e, omitting mention of the frame.
elucidation: An occurrent is an entity that unfolds itself in time or it is the instantaneous boundary of such an entity (for example a beginning or an ending) or it is a temporal or spatiotemporal region which such an entity occupies_temporal_region or occupies_spatiotemporal_region. (axiom label in BFO2 Reference: [077-002])
has associated axiom(nl): Every occurrent occupies_spatiotemporal_region some spatiotemporal region. (axiom label in BFO2 Reference: [108-001])
has associated axiom(nl): b is an occurrent entity iff b is an entity that has temporal parts. (axiom label in BFO2 Reference: [079-001])
has associated axiom(fol): (forall (x) (if (Occurrent x) (exists (r) (and (SpatioTemporalRegion r) (occupiesSpatioTemporalRegion x r))))) // axiom label in BFO2 CLIF: [108-001]
has associated axiom(fol): (forall (x) (iff (Occurrent x) (and (Entity x) (exists (y) (temporalPartOf y x))))) // axiom label in BFO2 CLIF: [079-001]
UNEP ignore: true

Axiom
annotated source: occurrent
annotated property: editor note
annotated target: Occurrent doesn't have a closure axiom because the subclasses don't necessarily exhaust all possibilites. An example would be the sum of a process and the process boundary of another process.
IAO_0010000: http://purl.obolibrary.org/obo/bfo/axiom/0000006
comment: per discussion with Barry Smith

Axiom
annotated source: occurrent
annotated property: editor note
annotated target: Simons uses different terminology for relations of occurrents to regions: Denote the spatio-temporal location of a given occurrent e by 'spn[e]' and call this region its span. We may say an occurrent is at its span, in any larger region, and covers any smaller region. Now suppose we have fixed a frame of reference so that we can speak not merely of spatio-temporal but also of spatial regions (places) and temporal regions (times). The spread of an occurrent, (relative to a frame of reference) is the space it exactly occupies, and its spell is likewise the time it exactly occupies. We write 'spr[e]' and `spl[e]' respectively for the spread and spell of e, omitting mention of the frame.
IAO_0010000: http://purl.obolibrary.org/obo/bfo/axiom/0000012

Axiom
annotated source: occurrent
annotated property: elucidation
annotated target: An occurrent is an entity that unfolds itself in time or it is the instantaneous boundary of such an entity (for example a beginning or an ending) or it is a temporal or spatiotemporal region which such an entity occupies_temporal_region or occupies_spatiotemporal_region. (axiom label in BFO2 Reference: [077-002])
IAO_0010000: http://purl.obolibrary.org/obo/bfo/axiom/077-002

Axiom
annotated source: occurrent
annotated property: has associated axiom(nl)
annotated target: Every occurrent occupies_spatiotemporal_region some spatiotemporal region. (axiom label in BFO2 Reference: [108-001])
IAO_0010000: http://purl.obolibrary.org/obo/bfo/axiom/108-001

Axiom
annotated source: occurrent
annotated property: has associated axiom(nl)
annotated target: b is an occurrent entity iff b is an entity that has temporal parts. (axiom label in BFO2 Reference: [079-001])
IAO_0010000: http://purl.obolibrary.org/obo/bfo/axiom/079-001

Axiom
annotated source: occurrent
annotated property: has associated axiom(fol)
annotated target: (forall (x) (if (Occurrent x) (exists (r) (and (SpatioTemporalRegion r) (occupiesSpatioTemporalRegion x r))))) // axiom label in BFO2 CLIF: [108-001]
IAO_0010000: http://purl.obolibrary.org/obo/bfo/axiom/108-001

Axiom
annotated source: occurrent
annotated property: has associated axiom(fol)
annotated target: (forall (x) (iff (Occurrent x) (and (Entity x) (exists (y) (temporalPartOf y x))))) // axiom label in BFO2 CLIF: [079-001]
IAO_0010000: http://purl.obolibrary.org/obo/bfo/axiom/079-001

independent continuant
type: Class
subclass of: continuant
BFO OWL specification label: ic
BFO CLIF specification label: IndependentContinuant
example of usage: a chair
example of usage: a heart
example of usage: a leg
example of usage: a molecule
example of usage: a spatial region
example of usage: an atom
example of usage: an orchestra.
example of usage: an organism
example of usage: the bottom right portion of a human torso
example of usage: the interior of your mouth
definition: A continuant that is a bearer of quality and realizable entity entities, in which other entities inhere and which itself cannot inhere in anything.
definition: b is an independent continuant = Def. b is a continuant which is such that there is no c and no t such that b s-depends_on c at t. (axiom label in BFO2 Reference: [017-002])
OBO foundry unique label: anatomical entity (BFO)
has associated axiom(nl): For any independent continuant b and any time t there is some spatial region r such that b is located_in r at t. (axiom label in BFO2 Reference: [134-001])
has associated axiom(nl): For every independent continuant b and time t during the region of time spanned by its life, there are entities which s-depends_on b during t. (axiom label in BFO2 Reference: [018-002])
has associated axiom(fol): (forall (x t) (if (IndependentContinuant x) (exists (r) (and (SpatialRegion r) (locatedInAt x r t))))) // axiom label in BFO2 CLIF: [134-001]
has associated axiom(fol): (forall (x t) (if (and (IndependentContinuant x) (existsAt x t)) (exists (y) (and (Entity y) (specificallyDependsOnAt y x t))))) // axiom label in BFO2 CLIF: [018-002]
has associated axiom(fol): (iff (IndependentContinuant a) (and (Continuant a) (not (exists (b t) (specificallyDependsOnAt a b t))))) // axiom label in BFO2 CLIF: [017-002]
UNEP ignore: true
comment: A continuant that is a bearer of quality and realizable entity entities, in which other entities inhere and which itself cannot inhere in anything.

Axiom
annotated source: independent continuant
annotated property: definition
annotated target: b is an independent continuant = Def. b is a continuant which is such that there is no c and no t such that b s-depends_on c at t. (axiom label in BFO2 Reference: [017-002])
IAO_0010000: http://purl.obolibrary.org/obo/bfo/axiom/017-002

Axiom
annotated source: independent continuant
annotated property: has associated axiom(nl)
annotated target: For any independent continuant b and any time t there is some spatial region r such that b is located_in r at t. (axiom label in BFO2 Reference: [134-001])
IAO_0010000: http://purl.obolibrary.org/obo/bfo/axiom/134-001

Axiom
annotated source: independent continuant
annotated property: has associated axiom(nl)
annotated target: For every independent continuant b and time t during the region of time spanned by its life, there are entities which s-depends_on b during t. (axiom label in BFO2 Reference: [018-002])
IAO_0010000: http://purl.obolibrary.org/obo/bfo/axiom/018-002

Axiom
annotated source: independent continuant
annotated property: has associated axiom(fol)
annotated target: (forall (x t) (if (IndependentContinuant x) (exists (r) (and (SpatialRegion r) (locatedInAt x r t))))) // axiom label in BFO2 CLIF: [134-001]
IAO_0010000: http://purl.obolibrary.org/obo/bfo/axiom/134-001

Axiom
annotated source: independent continuant
annotated property: has associated axiom(fol)
annotated target: (forall (x t) (if (and (IndependentContinuant x) (existsAt x t)) (exists (y) (and (Entity y) (specificallyDependsOnAt y x t))))) // axiom label in BFO2 CLIF: [018-002]
IAO_0010000: http://purl.obolibrary.org/obo/bfo/axiom/018-002

Axiom
annotated source: independent continuant
annotated property: has associated axiom(fol)
annotated target: (iff (IndependentContinuant a) (and (Continuant a) (not (exists (b t) (specificallyDependsOnAt a b t))))) // axiom label in BFO2 CLIF: [017-002]
IAO_0010000: http://purl.obolibrary.org/obo/bfo/axiom/017-002

spatial region
type: Class
subclass of: immaterial entity
BFO OWL specification label: s-region
BFO CLIF specification label: SpatialRegion
has curation status: External
definition: A continuant entity that is a continuant_part_of spaceR as defined relative to some frame R
editor note: BFO 2 Reference: Spatial regions do not participate in processes.
editor note: Spatial region doesn't have a closure axiom because the subclasses don't exhaust all possibilites. An example would be the union of a spatial point and a spatial line that doesn't overlap the point, or two spatial lines that intersect at a single point. In both cases the resultant spatial region is neither 0-dimensional, 1-dimensional, 2-dimensional, or 3-dimensional.
elucidation: A spatial region is a continuant entity that is a continuant_part_of spaceR as defined relative to some frame R. (axiom label in BFO2 Reference: [035-001])
has associated axiom(nl): All continuant parts of spatial regions are spatial regions. (axiom label in BFO2 Reference: [036-001])
has associated axiom(fol): (forall (x y t) (if (and (SpatialRegion x) (continuantPartOfAt y x t)) (SpatialRegion y))) // axiom label in BFO2 CLIF: [036-001]
has associated axiom(fol): (forall (x) (if (SpatialRegion x) (Continuant x))) // axiom label in BFO2 CLIF: [035-001]

Axiom
annotated source: spatial region
annotated property: editor note
annotated target: Spatial region doesn't have a closure axiom because the subclasses don't exhaust all possibilites. An example would be the union of a spatial point and a spatial line that doesn't overlap the point, or two spatial lines that intersect at a single point. In both cases the resultant spatial region is neither 0-dimensional, 1-dimensional, 2-dimensional, or 3-dimensional.
IAO_0010000: http://purl.obolibrary.org/obo/bfo/axiom/0000002
comment: per discussion with Barry Smith

Axiom
annotated source: spatial region
annotated property: elucidation
annotated target: A spatial region is a continuant entity that is a continuant_part_of spaceR as defined relative to some frame R. (axiom label in BFO2 Reference: [035-001])
IAO_0010000: http://purl.obolibrary.org/obo/bfo/axiom/035-001

Axiom
annotated source: spatial region
annotated property: has associated axiom(nl)
annotated target: All continuant parts of spatial regions are spatial regions. (axiom label in BFO2 Reference: [036-001])
IAO_0010000: http://purl.obolibrary.org/obo/bfo/axiom/036-001

Axiom
annotated source: spatial region
annotated property: has associated axiom(fol)
annotated target: (forall (x y t) (if (and (SpatialRegion x) (continuantPartOfAt y x t)) (SpatialRegion y))) // axiom label in BFO2 CLIF: [036-001]
IAO_0010000: http://purl.obolibrary.org/obo/bfo/axiom/036-001

Axiom
annotated source: spatial region
annotated property: has associated axiom(fol)
annotated target: (forall (x) (if (SpatialRegion x) (Continuant x))) // axiom label in BFO2 CLIF: [035-001]
IAO_0010000: http://purl.obolibrary.org/obo/bfo/axiom/035-001

temporal region
type: Class
subclass of: occurrent
BFO OWL specification label: t-region
BFO CLIF specification label: TemporalRegion
editor note: Temporal region doesn't have a closure axiom because the subclasses don't exhaust all possibilites. An example would be the mereological sum of a temporal instant and a temporal interval that doesn't overlap the instant. In this case the resultant temporal region is neither 0-dimensional nor 1-dimensional
elucidation: A temporal region is an occurrent entity that is part of time as defined relative to some reference frame. (axiom label in BFO2 Reference: [100-001])
has associated axiom(nl): All parts of temporal regions are temporal regions. (axiom label in BFO2 Reference: [101-001])
has associated axiom(nl): Every temporal region t is such that t occupies_temporal_region t. (axiom label in BFO2 Reference: [119-002])
has associated axiom(fol): (forall (r) (if (TemporalRegion r) (occupiesTemporalRegion r r))) // axiom label in BFO2 CLIF: [119-002]
has associated axiom(fol): (forall (x y) (if (and (TemporalRegion x) (occurrentPartOf y x)) (TemporalRegion y))) // axiom label in BFO2 CLIF: [101-001]
has associated axiom(fol): (forall (x) (if (TemporalRegion x) (Occurrent x))) // axiom label in BFO2 CLIF: [100-001]

Axiom
annotated source: temporal region
annotated property: editor note
annotated target: Temporal region doesn't have a closure axiom because the subclasses don't exhaust all possibilites. An example would be the mereological sum of a temporal instant and a temporal interval that doesn't overlap the instant. In this case the resultant temporal region is neither 0-dimensional nor 1-dimensional
IAO_0010000: http://purl.obolibrary.org/obo/bfo/axiom/0000003
comment: per discussion with Barry Smith

Axiom
annotated source: temporal region
annotated property: elucidation
annotated target: A temporal region is an occurrent entity that is part of time as defined relative to some reference frame. (axiom label in BFO2 Reference: [100-001])
IAO_0010000: http://purl.obolibrary.org/obo/bfo/axiom/100-001

Axiom
annotated source: temporal region
annotated property: has associated axiom(nl)
annotated target: All parts of temporal regions are temporal regions. (axiom label in BFO2 Reference: [101-001])
IAO_0010000: http://purl.obolibrary.org/obo/bfo/axiom/101-001

Axiom
annotated source: temporal region
annotated property: has associated axiom(nl)
annotated target: Every temporal region t is such that t occupies_temporal_region t. (axiom label in BFO2 Reference: [119-002])
IAO_0010000: http://purl.obolibrary.org/obo/bfo/axiom/119-002

Axiom
annotated source: temporal region
annotated property: has associated axiom(fol)
annotated target: (forall (r) (if (TemporalRegion r) (occupiesTemporalRegion r r))) // axiom label in BFO2 CLIF: [119-002]
IAO_0010000: http://purl.obolibrary.org/obo/bfo/axiom/119-002

Axiom
annotated source: temporal region
annotated property: has associated axiom(fol)
annotated target: (forall (x y) (if (and (TemporalRegion x) (occurrentPartOf y x)) (TemporalRegion y))) // axiom label in BFO2 CLIF: [101-001]
IAO_0010000: http://purl.obolibrary.org/obo/bfo/axiom/101-001

Axiom
annotated source: temporal region
annotated property: has associated axiom(fol)
annotated target: (forall (x) (if (TemporalRegion x) (Occurrent x))) // axiom label in BFO2 CLIF: [100-001]
IAO_0010000: http://purl.obolibrary.org/obo/bfo/axiom/100-001

process
type: Class
subclass of: occurrent
BFO OWL specification label: process
BFO CLIF specification label: Process
example of usage: a process of cell-division, \ a beating of the heart
example of usage: a process of meiosis
example of usage: a process of sleeping
example of usage: the course of a disease
example of usage: the flight of a bird
example of usage: the life of an organism
example of usage: your process of aging.
definition: An occurrent that has temporal proper parts and for some time t, p s-depends_on some material entity at t.
definition: p is a process = Def. p is an occurrent that has temporal proper parts and for some time t, p s-depends_on some material entity at t. (axiom label in BFO2 Reference: [083-003])
editor note: BFO 2 Reference: The realm of occurrents is less pervasively marked by the presence of natural units than is the case in the realm of independent continuants. Thus there is here no counterpart of ‘object’. In BFO 1.0 ‘process’ served as such a counterpart. In BFO 2.0 ‘process’ is, rather, the occurrent counterpart of ‘material entity’. Those natural – as contrasted with engineered, which here means: deliberately executed – units which do exist in the realm of occurrents are typically either parasitic on the existence of natural units on the continuant side, or they are fiat in nature. Thus we can count lives; we can count football games; we can count chemical reactions performed in experiments or in chemical manufacturing. We cannot count the processes taking place, for instance, in an episode of insect mating behavior.Even where natural units are identifiable, for example cycles in a cyclical process such as the beating of a heart or an organism’s sleep/wake cycle, the processes in question form a sequence with no discontinuities (temporal gaps) of the sort that we find for instance where billiard balls or zebrafish or planets are separated by clear spatial gaps. Lives of organisms are process units, but they too unfold in a continuous series from other, prior processes such as fertilization, and they unfold in turn in continuous series of post-life processes such as post-mortem decay. Clear examples of boundaries of processes are almost always of the fiat sort (midnight, a time of death as declared in an operating theater or on a death certificate, the initiation of a state of war)
has associated axiom(fol): (iff (Process a) (and (Occurrent a) (exists (b) (properTemporalPartOf b a)) (exists (c t) (and (MaterialEntity c) (specificallyDependsOnAt a c t))))) // axiom label in BFO2 CLIF: [083-003]
id: BFO:0000015
comment: An occurrent that has temporal proper parts and for some time t, p s-depends_on some material entity at t.

Axiom
annotated source: process
annotated property: definition
annotated target: p is a process = Def. p is an occurrent that has temporal proper parts and for some time t, p s-depends_on some material entity at t. (axiom label in BFO2 Reference: [083-003])
IAO_0010000: http://purl.obolibrary.org/obo/bfo/axiom/083-003

Axiom
annotated source: process
annotated property: has associated axiom(fol)
annotated target: (iff (Process a) (and (Occurrent a) (exists (b) (properTemporalPartOf b a)) (exists (c t) (and (MaterialEntity c) (specificallyDependsOnAt a c t))))) // axiom label in BFO2 CLIF: [083-003]
IAO_0010000: http://purl.obolibrary.org/obo/bfo/axiom/083-003

disposition
type: Class
subclass of: realizable
BFO OWL specification label: disposition
BFO CLIF specification label: Disposition
example of usage: an atom of element X has the disposition to decay to an atom of element Y
example of usage: certain people have a predisposition to colon cancer
example of usage: children are innately disposed to categorize objects in certain ways.
example of usage: the cell wall is disposed to filter chemicals in endocytosis and exocytosis
editor note: BFO 2 Reference: Dispositions exist along a strength continuum. Weaker forms of disposition are realized in only a fraction of triggering cases. These forms occur in a significant number of cases of a similar type.
elucidation: b is a disposition means: b is a realizable entity & b’s bearer is some material entity & b is such that if it ceases to exist, then its bearer is physically changed, & b’s realization occurs when and because this bearer is in some special physical circumstances, & this realization occurs in virtue of the bearer’s physical make-up. (axiom label in BFO2 Reference: [062-002])
has associated axiom(nl): If b is a realizable entity then for all t at which b exists, b s-depends_on some material entity at t. (axiom label in BFO2 Reference: [063-002])
has associated axiom(fol): (forall (x t) (if (and (RealizableEntity x) (existsAt x t)) (exists (y) (and (MaterialEntity y) (specificallyDepends x y t))))) // axiom label in BFO2 CLIF: [063-002]
has associated axiom(fol): (forall (x) (if (Disposition x) (and (RealizableEntity x) (exists (y) (and (MaterialEntity y) (bearerOfAt x y t)))))) // axiom label in BFO2 CLIF: [062-002]

Axiom
annotated source: disposition
annotated property: elucidation
annotated target: b is a disposition means: b is a realizable entity & b’s bearer is some material entity & b is such that if it ceases to exist, then its bearer is physically changed, & b’s realization occurs when and because this bearer is in some special physical circumstances, & this realization occurs in virtue of the bearer’s physical make-up. (axiom label in BFO2 Reference: [062-002])
IAO_0010000: http://purl.obolibrary.org/obo/bfo/axiom/062-002

Axiom
annotated source: disposition
annotated property: has associated axiom(nl)
annotated target: If b is a realizable entity then for all t at which b exists, b s-depends_on some material entity at t. (axiom label in BFO2 Reference: [063-002])
IAO_0010000: http://purl.obolibrary.org/obo/bfo/axiom/063-002

Axiom
annotated source: disposition
annotated property: has associated axiom(fol)
annotated target: (forall (x t) (if (and (RealizableEntity x) (existsAt x t)) (exists (y) (and (MaterialEntity y) (specificallyDepends x y t))))) // axiom label in BFO2 CLIF: [063-002]
IAO_0010000: http://purl.obolibrary.org/obo/bfo/axiom/063-002

Axiom
annotated source: disposition
annotated property: has associated axiom(fol)
annotated target: (forall (x) (if (Disposition x) (and (RealizableEntity x) (exists (y) (and (MaterialEntity y) (bearerOfAt x y t)))))) // axiom label in BFO2 CLIF: [062-002]
IAO_0010000: http://purl.obolibrary.org/obo/bfo/axiom/062-002

realizable
type: Class
subclass of: specifically dependent continuant
BFO OWL specification label: realizable
BFO CLIF specification label: RealizableEntity
example of usage: the disposition of this piece of metal to conduct electricity.
example of usage: the disposition of your blood to coagulate
example of usage: the function of your reproductive organs
example of usage: the role of being a doctor
example of usage: the role of this boundary to delineate where Utah and Colorado meet
definition: A specifically dependent continuant that inheres in continuant entities and are not exhibited in full at every time in which it inheres in an entity or group of entities. The exhibition or actualization of a realizable entity is a particular manifestation, functioning or process that occurs under certain circumstances.
imported from: dron.owl
imported from: envo.owl
imported from: obi.owl
imported from: obib.owl
imported from: ogms.owl
imported from: omrse.owl
elucidation: To say that b is a realizable entity is to say that b is a specifically dependent continuant that inheres in some independent continuant which is not a spatial region and is of a type instances of which are realized in processes of a correlated type. (axiom label in BFO2 Reference: [058-002])
has associated axiom(nl): All realizable dependent continuants have independent continuants that are not spatial regions as their bearers. (axiom label in BFO2 Reference: [060-002])
has associated axiom(fol): (forall (x t) (if (RealizableEntity x) (exists (y) (and (IndependentContinuant y) (not (SpatialRegion y)) (bearerOfAt y x t))))) // axiom label in BFO2 CLIF: [060-002]
has associated axiom(fol): (forall (x) (if (RealizableEntity x) (and (SpecificallyDependentContinuant x) (exists (y) (and (IndependentContinuant y) (not (SpatialRegion y)) (inheresIn x y)))))) // axiom label in BFO2 CLIF: [058-002]
label: realizable entity

Axiom
annotated source: realizable
annotated property: elucidation
annotated target: To say that b is a realizable entity is to say that b is a specifically dependent continuant that inheres in some independent continuant which is not a spatial region and is of a type instances of which are realized in processes of a correlated type. (axiom label in BFO2 Reference: [058-002])
IAO_0010000: http://purl.obolibrary.org/obo/bfo/axiom/058-002

Axiom
annotated source: realizable
annotated property: has associated axiom(nl)
annotated target: All realizable dependent continuants have independent continuants that are not spatial regions as their bearers. (axiom label in BFO2 Reference: [060-002])
IAO_0010000: http://purl.obolibrary.org/obo/bfo/axiom/060-002

Axiom
annotated source: realizable
annotated property: has associated axiom(fol)
annotated target: (forall (x t) (if (RealizableEntity x) (exists (y) (and (IndependentContinuant y) (not (SpatialRegion y)) (bearerOfAt y x t))))) // axiom label in BFO2 CLIF: [060-002]
IAO_0010000: http://purl.obolibrary.org/obo/bfo/axiom/060-002

Axiom
annotated source: realizable
annotated property: has associated axiom(fol)
annotated target: (forall (x) (if (RealizableEntity x) (and (SpecificallyDependentContinuant x) (exists (y) (and (IndependentContinuant y) (not (SpatialRegion y)) (inheresIn x y)))))) // axiom label in BFO2 CLIF: [058-002]
IAO_0010000: http://purl.obolibrary.org/obo/bfo/axiom/058-002

specifically dependent continuant
type: Class
subclass of: continuant
BFO OWL specification label: sdc
BFO CLIF specification label: SpecificallyDependentContinuant
editor preferred label: specifically dependent continuant
example of usage: Reciprocal specifically dependent continuants: the function of this key to open this lock and the mutually dependent disposition of this lock: to be opened by this key
example of usage: of one-sided specifically dependent continuants: the mass of this tomato
example of usage: of relational dependent continuants (multiple bearers): John’s love for Mary, the ownership relation between John and this statue, the relation of authority between John and his subordinates.
example of usage: the disposition of this fish to decay
example of usage: the function of this heart: to pump blood
example of usage: the mutual dependence of proton donors and acceptors in chemical reactions [79
example of usage: the mutual dependence of the role predator and the role prey as played by two organisms in a given interaction
example of usage: the pink color of a medium rare piece of grilled filet mignon at its center
example of usage: the role of being a doctor
example of usage: the shape of this hole.
example of usage: the smell of this portion of mozzarella
has curation status: External
definition: A continuant that inheres in or is borne by other entities. Every instance of A requires some specific instance of B which must always be the same.
definition: b is a relational specifically dependent continuant = Def. b is a specifically dependent continuant and there are n > 1 independent continuants c1, … cn which are not spatial regions are such that for all 1 i < j n, ci and cj share no common parts, are such that for each 1 i n, b s-depends_on ci at every time t during the course of b’s existence (axiom label in BFO2 Reference: [131-004])
definition: b is a specifically dependent continuant = Def. b is a continuant & there is some independent continuant c which is not a spatial region and which is such that b s-depends_on c at every time t during the course of b’s existence. (axiom label in BFO2 Reference: [050-003])
definition: b is a specifically dependent continuant = Def. b is a continuant and there is some independent continuant c which is not a spatial region and which is such that b s-depends_on c at every time t during the course of b’s existence. (axiom label in BFO2 Reference: [050-003])
editor note: Specifically dependent continuant doesn't have a closure axiom because the subclasses don't necessarily exhaust all possibilites. We're not sure what else will develop here, but for example there are questions such as what are promises, obligation, etc.
imported from: bfo.owl
imported from: dron.owl
imported from: envo.owl
imported from: iao.owl
imported from: oae.owl
imported from: obi.owl
imported from: obib.owl
imported from: ogms.owl
imported from: omrse.owl
imported from: pato.owl
imported from: ro.owl
has associated axiom(fol): (iff (RelationalSpecificallyDependentContinuant a) (and (SpecificallyDependentContinuant a) (forall (t) (exists (b c) (and (not (SpatialRegion b)) (not (SpatialRegion c)) (not (= b c)) (not (exists (d) (and (continuantPartOfAt d b t) (continuantPartOfAt d c t)))) (specificallyDependsOnAt a b t) (specificallyDependsOnAt a c t)))))) // axiom label in BFO2 CLIF: [131-004]
has associated axiom(fol): (iff (SpecificallyDependentContinuant a) (and (Continuant a) (forall (t) (if (existsAt a t) (exists (b) (and (IndependentContinuant b) (not (SpatialRegion b)) (specificallyDependsOnAt a b t))))))) // axiom label in BFO2 CLIF: [050-003]
UNEP ignore: true
comment: A continuant that inheres in or is borne by other entities. Every instance of A requires some specific instance of B which must always be the same.
label: characteristic

Axiom
annotated source: specifically dependent continuant
annotated property: definition
annotated target: b is a relational specifically dependent continuant = Def. b is a specifically dependent continuant and there are n > 1 independent continuants c1, … cn which are not spatial regions are such that for all 1 i < j n, ci and cj share no common parts, are such that for each 1 i n, b s-depends_on ci at every time t during the course of b’s existence (axiom label in BFO2 Reference: [131-004])
IAO_0010000: http://purl.obolibrary.org/obo/bfo/axiom/131-004

Axiom
annotated source: specifically dependent continuant
annotated property: definition
annotated target: b is a specifically dependent continuant = Def. b is a continuant & there is some independent continuant c which is not a spatial region and which is such that b s-depends_on c at every time t during the course of b’s existence. (axiom label in BFO2 Reference: [050-003])
IAO_0010000: http://purl.obolibrary.org/obo/bfo/axiom/050-003

Axiom
annotated source: specifically dependent continuant
annotated property: editor note
annotated target: Specifically dependent continuant doesn't have a closure axiom because the subclasses don't necessarily exhaust all possibilites. We're not sure what else will develop here, but for example there are questions such as what are promises, obligation, etc.
IAO_0010000: http://purl.obolibrary.org/obo/bfo/axiom/0000005
comment: per discussion with Barry Smith

Axiom
annotated source: specifically dependent continuant
annotated property: has associated axiom(fol)
annotated target: (iff (RelationalSpecificallyDependentContinuant a) (and (SpecificallyDependentContinuant a) (forall (t) (exists (b c) (and (not (SpatialRegion b)) (not (SpatialRegion c)) (not (= b c)) (not (exists (d) (and (continuantPartOfAt d b t) (continuantPartOfAt d c t)))) (specificallyDependsOnAt a b t) (specificallyDependsOnAt a c t)))))) // axiom label in BFO2 CLIF: [131-004]
IAO_0010000: http://purl.obolibrary.org/obo/bfo/axiom/131-004

Axiom
annotated source: specifically dependent continuant
annotated property: has associated axiom(fol)
annotated target: (iff (SpecificallyDependentContinuant a) (and (Continuant a) (forall (t) (if (existsAt a t) (exists (b) (and (IndependentContinuant b) (not (SpatialRegion b)) (specificallyDependsOnAt a b t))))))) // axiom label in BFO2 CLIF: [050-003]
IAO_0010000: http://purl.obolibrary.org/obo/bfo/axiom/050-003

role
type: Class
subclass of: realizable
BFO OWL specification label: role
BFO CLIF specification label: Role
example of usage: John’s role of husband to Mary is dependent on Mary’s role of wife to John, and both are dependent on the object aggregate comprising John and Mary as member parts joined together through the relational quality of being married.
example of usage: the priest role
example of usage: the role of a boundary to demarcate two neighboring administrative territories
example of usage: the role of a building in serving as a military target
example of usage: the role of a stone in marking a property boundary
example of usage: the role of subject in a clinical trial
example of usage: the student role
has curation status: External
definition: A realizable entity the manifestation of which brings about some result or end that is not essential to a continuant in virtue of the kind of thing that it is but that can be served or participated in by that kind of continuant in some kinds of natural, social or institutional contexts.
definition: b is a role means: b is a realizable entity and b exists because there is some single bearer that is in some special physical, social, or institutional set of circumstances in which this bearer does not have to beand b is not such that, if it ceases to exist, then the physical make-up of the bearer is thereby changed.
editor note: BFO 2 Reference: One major family of examples of non-rigid universals involves roles, and ontologies developed for corresponding administrative purposes may consist entirely of representatives of entities of this sort. Thus ‘professor’, defined as follows,b instance_of professor at t =Def. there is some c, c instance_of professor role & c inheres_in b at t.denotes a non-rigid universal and so also do ‘nurse’, ‘student’, ‘colonel’, ‘taxpayer’, and so forth. (These terms are all, in the jargon of philosophy, phase sortals.) By using role terms in definitions, we can create a BFO conformant treatment of such entities drawing on the fact that, while an instance of professor may be simultaneously an instance of trade union member, no instance of the type professor role is also (at any time) an instance of the type trade union member role (any more than any instance of the type color is at any time an instance of the type length).If an ontology of employment positions should be defined in terms of roles following the above pattern, this enables the ontology to do justice to the fact that individuals instantiate the corresponding universals – professor, sergeant, nurse – only during certain phases in their lives.
elucidation: b is a role means: b is a realizable entity & b exists because there is some single bearer that is in some special physical, social, or institutional set of circumstances in which this bearer does not have to be& b is not such that, if it ceases to exist, then the physical make-up of the bearer is thereby changed. (axiom label in BFO2 Reference: [061-001])
has associated axiom(fol): (forall (x) (if (Role x) (RealizableEntity x))) // axiom label in BFO2 CLIF: [061-001]

Axiom
annotated source: role
annotated property: elucidation
annotated target: b is a role means: b is a realizable entity & b exists because there is some single bearer that is in some special physical, social, or institutional set of circumstances in which this bearer does not have to be& b is not such that, if it ceases to exist, then the physical make-up of the bearer is thereby changed. (axiom label in BFO2 Reference: [061-001])
IAO_0010000: http://purl.obolibrary.org/obo/bfo/axiom/061-001

Axiom
annotated source: role
annotated property: has associated axiom(fol)
annotated target: (forall (x) (if (Role x) (RealizableEntity x))) // axiom label in BFO2 CLIF: [061-001]
IAO_0010000: http://purl.obolibrary.org/obo/bfo/axiom/061-001

fiat object part
type: Class
subclass of: material entity
BFO OWL specification label: fiat-object-part
BFO CLIF specification label: FiatObjectPart
example of usage: or with divisions drawn by cognitive subjects for practical reasons, such as the division of a cake (before slicing) into (what will become) slices (and thus member parts of an object aggregate). However, this does not mean that fiat object parts are dependent for their existence on divisions or delineations effected by cognitive subjects. If, for example, it is correct to conceive geological layers of the Earth as fiat object parts of the Earth, then even though these layers were first delineated in recent times, still existed long before such delineation and what holds of these layers (for example that the oldest layers are also the lowest layers) did not begin to hold because of our acts of delineation.Treatment of material entity in BFOExamples viewed by some as problematic cases for the trichotomy of fiat object part, object, and object aggregate include: a mussel on (and attached to) a rock, a slime mold, a pizza, a cloud, a galaxy, a railway train with engine and multiple carriages, a clonal stand of quaking aspen, a bacterial community (biofilm), a broken femur. Note that, as Aristotle already clearly recognized, such problematic cases – which lie at or near the penumbra of instances defined by the categories in question – need not invalidate these categories. The existence of grey objects does not prove that there are not objects which are black and objects which are white; the existence of mules does not prove that there are not objects which are donkeys and objects which are horses. It does, however, show that the examples in question need to be addressed carefully in order to show how they can be fitted into the proposed scheme, for example by recognizing additional subdivisions [29
example of usage: the FMA:regional parts of an intact human body.
example of usage: the Western hemisphere of the Earth
example of usage: the division of the brain into regions
example of usage: the division of the planet into hemispheres
example of usage: the dorsal and ventral surfaces of the body
example of usage: the upper and lower lobes of the left lung
has curation status: External
definition: A material entity that is considered to be an object.
editor note: BFO 2 Reference: Most examples of fiat object parts are associated with theoretically drawn divisions
elucidation: b is a fiat object part = Def. b is a material entity which is such that for all times t, if b exists at t then there is some object c such that b proper continuant_part of c at t and c is demarcated from the remainder of c by a two-dimensional continuant fiat boundary. (axiom label in BFO2 Reference: [027-004])
has associated axiom(fol): (forall (x) (if (FiatObjectPart x) (and (MaterialEntity x) (forall (t) (if (existsAt x t) (exists (y) (and (Object y) (properContinuantPartOfAt x y t)))))))) // axiom label in BFO2 CLIF: [027-004]

Axiom
annotated source: fiat object part
annotated property: elucidation
annotated target: b is a fiat object part = Def. b is a material entity which is such that for all times t, if b exists at t then there is some object c such that b proper continuant_part of c at t and c is demarcated from the remainder of c by a two-dimensional continuant fiat boundary. (axiom label in BFO2 Reference: [027-004])
IAO_0010000: http://purl.obolibrary.org/obo/bfo/axiom/027-004

Axiom
annotated source: fiat object part
annotated property: has associated axiom(fol)
annotated target: (forall (x) (if (FiatObjectPart x) (and (MaterialEntity x) (forall (t) (if (existsAt x t) (exists (y) (and (Object y) (properContinuantPartOfAt x y t)))))))) // axiom label in BFO2 CLIF: [027-004]
IAO_0010000: http://purl.obolibrary.org/obo/bfo/axiom/027-004

object aggregate
type: Class
subclass of: material entity
BFO OWL specification label: object-aggregate
BFO CLIF specification label: ObjectAggregate
example of usage: a collection of cells in a blood biobank.
example of usage: a swarm of bees is an aggregate of members who are linked together through natural bonds
example of usage: a symphony orchestra
example of usage: an organization is an aggregate whose member parts have roles of specific types (for example in a jazz band, a chess club, a football team)
example of usage: defined by fiat: the aggregate of members of an organization
example of usage: defined through physical attachment: the aggregate of atoms in a lump of granite
example of usage: defined through physical containment: the aggregate of molecules of carbon dioxide in a sealed container
example of usage: defined via attributive delimitations such as: the patients in this hospital
example of usage: the aggregate of bearings in a constant velocity axle joint
example of usage: the aggregate of blood cells in your body
example of usage: the nitrogen atoms in the atmosphere
example of usage: the restaurants in Palo Alto
example of usage: your collection of Meissen ceramic plates.
editor note: An entity a is an object aggregate if and only if there is a mutually exhaustive and pairwise disjoint partition of a into objects
editor note: BFO 2 Reference: object aggregates may gain and lose parts while remaining numerically identical (one and the same individual) over time. This holds both for aggregates whose membership is determined naturally (the aggregate of cells in your body) and aggregates determined by fiat (a baseball team, a congressional committee).
definition source: ISBN:978-3-938793-98-5pp124-158#Thomas Bittner and Barry Smith, 'A Theory of Granular Partitions', in K. Munn and B. Smith (eds.), Applied Ontology: An Introduction, Frankfurt/Lancaster: ontos, 2008, 125-158.
elucidation: b is an object aggregate means: b is a material entity consisting exactly of a plurality of objects as member_parts at all times at which b exists. (axiom label in BFO2 Reference: [025-004])
has associated axiom(fol): (forall (x) (if (ObjectAggregate x) (and (MaterialEntity x) (forall (t) (if (existsAt x t) (exists (y z) (and (Object y) (Object z) (memberPartOfAt y x t) (memberPartOfAt z x t) (not (= y z)))))) (not (exists (w t_1) (and (memberPartOfAt w x t_1) (not (Object w)))))))) // axiom label in BFO2 CLIF: [025-004]

Axiom
annotated source: object aggregate
annotated property: editor note
annotated target: An entity a is an object aggregate if and only if there is a mutually exhaustive and pairwise disjoint partition of a into objects
IAO_0010000: http://purl.obolibrary.org/obo/bfo/axiom/0000011

Axiom
annotated source: object aggregate
annotated property: editor note
annotated target: An entity a is an object aggregate if and only if there is a mutually exhaustive and pairwise disjoint partition of a into objects
IAO_0010000: http://purl.obolibrary.org/obo/bfo/axiom/0000301

Axiom
annotated source: object aggregate
annotated property: definition source
annotated target: ISBN:978-3-938793-98-5pp124-158#Thomas Bittner and Barry Smith, 'A Theory of Granular Partitions', in K. Munn and B. Smith (eds.), Applied Ontology: An Introduction, Frankfurt/Lancaster: ontos, 2008, 125-158.
IAO_0010000: http://purl.obolibrary.org/obo/bfo/axiom/0000300

Axiom
annotated source: object aggregate
annotated property: elucidation
annotated target: b is an object aggregate means: b is a material entity consisting exactly of a plurality of objects as member_parts at all times at which b exists. (axiom label in BFO2 Reference: [025-004])
IAO_0010000: http://purl.obolibrary.org/obo/bfo/axiom/025-004

Axiom
annotated source: object aggregate
annotated property: has associated axiom(fol)
annotated target: (forall (x) (if (ObjectAggregate x) (and (MaterialEntity x) (forall (t) (if (existsAt x t) (exists (y z) (and (Object y) (Object z) (memberPartOfAt y x t) (memberPartOfAt z x t) (not (= y z)))))) (not (exists (w t_1) (and (memberPartOfAt w x t_1) (not (Object w)))))))) // axiom label in BFO2 CLIF: [025-004]
IAO_0010000: http://purl.obolibrary.org/obo/bfo/axiom/025-004

site
type: Class
subclass of: immaterial entity
BFO OWL specification label: site
BFO CLIF specification label: Site
example of usage: Manhattan Canyon)
example of usage: a hole in the interior of a portion of cheese
example of usage: a rabbit hole
example of usage: an air traffic control region defined in the airspace above an airport
example of usage: the Grand Canyon
example of usage: the Piazza San Marco
example of usage: the cockpit of an aircraft
example of usage: the hold of a ship
example of usage: the interior of a kangaroo pouch
example of usage: the interior of the trunk of your car
example of usage: the interior of your bedroom
example of usage: the interior of your office
example of usage: the interior of your refrigerator
example of usage: the lumen of your gut
example of usage: your left nostril (a fiat part – the opening – of your left nasal cavity)
has curation status: External
definition: A three-dimensional immaterial entity that is (partially or wholly) bounded by a material entity or it is a three-dimensional immaterial part thereof.
elucidation: b is a site means: b is a three-dimensional immaterial entity that is (partially or wholly) bounded by a material entity or it is a three-dimensional immaterial part thereof. (axiom label in BFO2 Reference: [034-002])
has associated axiom(fol): (forall (x) (if (Site x) (ImmaterialEntity x))) // axiom label in BFO2 CLIF: [034-002]

Axiom
annotated source: site
annotated property: elucidation
annotated target: b is a site means: b is a three-dimensional immaterial entity that is (partially or wholly) bounded by a material entity or it is a three-dimensional immaterial part thereof. (axiom label in BFO2 Reference: [034-002])
IAO_0010000: http://purl.obolibrary.org/obo/bfo/axiom/034-002

Axiom
annotated source: site
annotated property: has associated axiom(fol)
annotated target: (forall (x) (if (Site x) (ImmaterialEntity x))) // axiom label in BFO2 CLIF: [034-002]
IAO_0010000: http://purl.obolibrary.org/obo/bfo/axiom/034-002

object
type: Class
subclass of: material entity
BFO OWL specification label: object
BFO CLIF specification label: Object
example of usage: atom
example of usage: cell
example of usage: cells and organisms
example of usage: engineered artifacts
example of usage: grain of sand
example of usage: molecule
example of usage: organelle
example of usage: organism
example of usage: planet
example of usage: solid portions of matter
example of usage: star
editor note: BFO 2 Reference: BFO rests on the presupposition that at multiple micro-, meso- and macroscopic scales reality exhibits certain stable, spatially separated or separable material units, combined or combinable into aggregates of various sorts (for example organisms into what are called ‘populations’). Such units play a central role in almost all domains of natural science from particle physics to cosmology. Many scientific laws govern the units in question, employing general terms (such as ‘molecule’ or ‘planet’) referring to the types and subtypes of units, and also to the types and subtypes of the processes through which such units develop and interact. The division of reality into such natural units is at the heart of biological science, as also is the fact that these units may form higher-level units (as cells form multicellular organisms) and that they may also form aggregates of units, for example as cells form portions of tissue and organs form families, herds, breeds, species, and so on. At the same time, the division of certain portions of reality into engineered units (manufactured artifacts) is the basis of modern industrial technology, which rests on the distributed mass production of engineered parts through division of labor and on their assembly into larger, compound units such as cars and laptops. The division of portions of reality into units is one starting point for the phenomenon of counting.
editor note: BFO 2 Reference: Each object is such that there are entities of which we can assert unproblematically that they lie in its interior, and other entities of which we can assert unproblematically that they lie in its exterior. This may not be so for entities lying at or near the boundary between the interior and exterior. This means that two objects – for example the two cells depicted in Figure 3 – may be such that there are material entities crossing their boundaries which belong determinately to neither cell. Something similar obtains in certain cases of conjoined twins (see below).
editor note: BFO 2 Reference: To say that b is causally unified means: b is a material entity which is such that its material parts are tied together in such a way that, in environments typical for entities of the type in question,if c, a continuant part of b that is in the interior of b at t, is larger than a certain threshold size (which will be determined differently from case to case, depending on factors such as porosity of external cover) and is moved in space to be at t at a location on the exterior of the spatial region that had been occupied by b at t, then either b’s other parts will be moved in coordinated fashion or b will be damaged (be affected, for example, by breakage or tearing) in the interval between t and t.causal changes in one part of b can have consequences for other parts of b without the mediation of any entity that lies on the exterior of b. Material entities with no proper material parts would satisfy these conditions trivially. Candidate examples of types of causal unity for material entities of more complex sorts are as follows (this is not intended to be an exhaustive list):CU1: Causal unity via physical coveringHere the parts in the interior of the unified entity are combined together causally through a common membrane or other physical covering\. The latter points outwards toward and may serve a protective function in relation to what lies on the exterior of the entity [13, 47
editor note: BFO 2 Reference: an object is a maximal causally unified material entity
editor note: BFO 2 Reference: ‘objects’ are sometimes referred to as ‘grains’ [74
elucidation: b is an object means: b is a material entity which manifests causal unity of one or other of the types CUn listed above & is of a type (a material universal) instances of which are maximal relative to this criterion of causal unity. (axiom label in BFO2 Reference: [024-001])

Axiom
annotated source: object
annotated property: elucidation
annotated target: b is an object means: b is a material entity which manifests causal unity of one or other of the types CUn listed above & is of a type (a material universal) instances of which are maximal relative to this criterion of causal unity. (axiom label in BFO2 Reference: [024-001])
IAO_0010000: http://purl.obolibrary.org/obo/bfo/axiom/024-001

generically dependent continuant
type: Class
subclass of: continuant
BFO OWL specification label: gdc
BFO CLIF specification label: GenericallyDependentContinuant
editor preferred label: generically dependent continuant
example of usage: The entries in your database are patterns instantiated as quality instances in your hard drive. The database itself is an aggregate of such patterns. When you create the database you create a particular instance of the generically dependent continuant type database. Each entry in the database is an instance of the generically dependent continuant type IAO: information content entity.
example of usage: the pdf file on your laptop, the pdf file that is a copy thereof on my laptop
example of usage: the sequence of this protein molecule; the sequence that is a copy thereof in that protein molecule.
definition: A continuant that is dependent on one or other independent continuant bearers. For every instance of A requires some instance of (an independent continuant type) B but which instance of B serves can change from time to time.
definition: b is a generically dependent continuant = Def. b is a continuant that g-depends_on one or more other entities. (axiom label in BFO2 Reference: [074-001])
has associated axiom(fol): (iff (GenericallyDependentContinuant a) (and (Continuant a) (exists (b t) (genericallyDependsOnAt a b t)))) // axiom label in BFO2 CLIF: [074-001]
comment: A continuant that is dependent on one or other independent continuant bearers. For every instance of A requires some instance of (an independent continuant type) B but which instance of B serves can change from time to time.

Axiom
annotated source: generically dependent continuant
annotated property: definition
annotated target: b is a generically dependent continuant = Def. b is a continuant that g-depends_on one or more other entities. (axiom label in BFO2 Reference: [074-001])
IAO_0010000: http://purl.obolibrary.org/obo/bfo/axiom/074-001

Axiom
annotated source: generically dependent continuant
annotated property: has associated axiom(fol)
annotated target: (iff (GenericallyDependentContinuant a) (and (Continuant a) (exists (b t) (genericallyDependsOnAt a b t)))) // axiom label in BFO2 CLIF: [074-001]
IAO_0010000: http://purl.obolibrary.org/obo/bfo/axiom/074-001

process boundary
type: Class
subclass of: occurrent
BFO OWL specification label: p-boundary
BFO CLIF specification label: ProcessBoundary
example of usage: the boundary between the 2nd and 3rd year of your life.
definition: p is a process boundary =Def. p is a temporal part of a process & p has no proper temporal parts. (axiom label in BFO2 Reference: [084-001])
has associated axiom(nl): Every process boundary occupies_temporal_region a zero-dimensional temporal region. (axiom label in BFO2 Reference: [085-002])
has associated axiom(fol): (forall (x) (if (ProcessBoundary x) (exists (y) (and (ZeroDimensionalTemporalRegion y) (occupiesTemporalRegion x y))))) // axiom label in BFO2 CLIF: [085-002]
has associated axiom(fol): (iff (ProcessBoundary a) (exists (p) (and (Process p) (temporalPartOf a p) (not (exists (b) (properTemporalPartOf b a)))))) // axiom label in BFO2 CLIF: [084-001]

Axiom
annotated source: process boundary
annotated property: definition
annotated target: p is a process boundary =Def. p is a temporal part of a process & p has no proper temporal parts. (axiom label in BFO2 Reference: [084-001])
IAO_0010000: http://purl.obolibrary.org/obo/bfo/axiom/084-001

Axiom
annotated source: process boundary
annotated property: has associated axiom(nl)
annotated target: Every process boundary occupies_temporal_region a zero-dimensional temporal region. (axiom label in BFO2 Reference: [085-002])
IAO_0010000: http://purl.obolibrary.org/obo/bfo/axiom/085-002

Axiom
annotated source: process boundary
annotated property: has associated axiom(fol)
annotated target: (forall (x) (if (ProcessBoundary x) (exists (y) (and (ZeroDimensionalTemporalRegion y) (occupiesTemporalRegion x y))))) // axiom label in BFO2 CLIF: [085-002]
IAO_0010000: http://purl.obolibrary.org/obo/bfo/axiom/085-002

Axiom
annotated source: process boundary
annotated property: has associated axiom(fol)
annotated target: (iff (ProcessBoundary a) (exists (p) (and (Process p) (temporalPartOf a p) (not (exists (b) (properTemporalPartOf b a)))))) // axiom label in BFO2 CLIF: [084-001]
IAO_0010000: http://purl.obolibrary.org/obo/bfo/axiom/084-001

one-dimensional temporal region
type: Class
subclass of: temporal region
BFO OWL specification label: 1d-t-region
BFO CLIF specification label: OneDimensionalTemporalRegion
example of usage: the temporal region during which a process occurs.
editor note: BFO 2 Reference: A temporal interval is a special kind of one-dimensional temporal region, namely one that is self-connected (is without gaps or breaks).
elucidation: A one-dimensional temporal region is a temporal region that is extended. (axiom label in BFO2 Reference: [103-001])
has associated axiom(fol): (forall (x) (if (OneDimensionalTemporalRegion x) (TemporalRegion x))) // axiom label in BFO2 CLIF: [103-001]

Axiom
annotated source: one-dimensional temporal region
annotated property: elucidation
annotated target: A one-dimensional temporal region is a temporal region that is extended. (axiom label in BFO2 Reference: [103-001])
IAO_0010000: http://purl.obolibrary.org/obo/bfo/axiom/103-001

Axiom
annotated source: one-dimensional temporal region
annotated property: has associated axiom(fol)
annotated target: (forall (x) (if (OneDimensionalTemporalRegion x) (TemporalRegion x))) // axiom label in BFO2 CLIF: [103-001]
IAO_0010000: http://purl.obolibrary.org/obo/bfo/axiom/103-001

material entity
type: Class
subclass of: independent continuant
BFO OWL specification label: material
BFO CLIF specification label: MaterialEntity
editor preferred label: material entity
example of usage: a flame
example of usage: a forest fire
example of usage: a human being
example of usage: a hurricane
example of usage: a photon
example of usage: a puff of smoke
example of usage: a sea wave
example of usage: a tornado
example of usage: an aggregate of human beings.
example of usage: an energy wave
example of usage: an epidemic
example of usage: the undetached arm of a human being
has curation status: External
definition: An <independent continuant> that is spatially extended whose identity is independent of that of other entities and can be maintained through time.
definition: An independent continuant that is spatially extended whose identity is independent of that of other entities and can be maintained through time.
editor note: BFO 2 Reference: Material entities (continuants) can preserve their identity even while gaining and losing material parts. Continuants are contrasted with occurrents, which unfold themselves in successive temporal parts or phases [60
editor note: BFO 2 Reference: Object, Fiat Object Part and Object Aggregate are not intended to be exhaustive of Material Entity. Users are invited to propose new subcategories of Material Entity.
editor note: BFO 2 Reference: ‘Matter’ is intended to encompass both mass and energy (we will address the ontological treatment of portions of energy in a later version of BFO). A portion of matter is anything that includes elementary particles among its proper or improper parts: quarks and leptons, including electrons, as the smallest particles thus far discovered; baryons (including protons and neutrons) at a higher level of granularity; atoms and molecules at still higher levels, forming the cells, organs, organisms and other material entities studied by biologists, the portions of rock studied by geologists, the fossils studied by paleontologists, and so on.Material entities are three-dimensional entities (entities extended in three spatial dimensions), as contrasted with the processes in which they participate, which are four-dimensional entities (entities extended also along the dimension of time).According to the FMA, material entities may have immaterial entities as parts – including the entities identified below as sites; for example the interior (or ‘lumen’) of your small intestine is a part of your body. BFO 2.0 embodies a decision to follow the FMA here.
editor note: Elucidation: An independent continuant that is spatially extended whose identity is independent of that of other entities and can be maintained through time.
imported from: cl.owl
imported from: ido.owl
imported from: uberon.owl
elucidation: A material entity is an independent continuant that has some portion of matter as proper or improper continuant part. (axiom label in BFO2 Reference: [019-002])
has associated axiom(nl): Every entity which has a material entity as continuant part is a material entity. (axiom label in BFO2 Reference: [020-002])
has associated axiom(nl): every entity of which a material entity is continuant part is also a material entity. (axiom label in BFO2 Reference: [021-002])
has associated axiom(fol): (forall (x) (if (MaterialEntity x) (IndependentContinuant x))) // axiom label in BFO2 CLIF: [019-002]
has associated axiom(fol): (forall (x) (if (and (Entity x) (exists (y t) (and (MaterialEntity y) (continuantPartOfAt x y t)))) (MaterialEntity x))) // axiom label in BFO2 CLIF: [021-002]
has associated axiom(fol): (forall (x) (if (and (Entity x) (exists (y t) (and (MaterialEntity y) (continuantPartOfAt y x t)))) (MaterialEntity x))) // axiom label in BFO2 CLIF: [020-002]
has_obo_namespace: bfo
id: BFO:0000040

Axiom
annotated source: material entity
annotated property: elucidation
annotated target: A material entity is an independent continuant that has some portion of matter as proper or improper continuant part. (axiom label in BFO2 Reference: [019-002])
IAO_0010000: http://purl.obolibrary.org/obo/bfo/axiom/019-002

Axiom
annotated source: material entity
annotated property: has associated axiom(nl)
annotated target: Every entity which has a material entity as continuant part is a material entity. (axiom label in BFO2 Reference: [020-002])
IAO_0010000: http://purl.obolibrary.org/obo/bfo/axiom/020-002

Axiom
annotated source: material entity
annotated property: has associated axiom(nl)
annotated target: every entity of which a material entity is continuant part is also a material entity. (axiom label in BFO2 Reference: [021-002])
IAO_0010000: http://purl.obolibrary.org/obo/bfo/axiom/021-002

Axiom
annotated source: material entity
annotated property: has associated axiom(fol)
annotated target: (forall (x) (if (MaterialEntity x) (IndependentContinuant x))) // axiom label in BFO2 CLIF: [019-002]
IAO_0010000: http://purl.obolibrary.org/obo/bfo/axiom/019-002

Axiom
annotated source: material entity
annotated property: has associated axiom(fol)
annotated target: (forall (x) (if (and (Entity x) (exists (y t) (and (MaterialEntity y) (continuantPartOfAt x y t)))) (MaterialEntity x))) // axiom label in BFO2 CLIF: [021-002]
IAO_0010000: http://purl.obolibrary.org/obo/bfo/axiom/021-002

Axiom
annotated source: material entity
annotated property: has associated axiom(fol)
annotated target: (forall (x) (if (and (Entity x) (exists (y t) (and (MaterialEntity y) (continuantPartOfAt y x t)))) (MaterialEntity x))) // axiom label in BFO2 CLIF: [020-002]
IAO_0010000: http://purl.obolibrary.org/obo/bfo/axiom/020-002

immaterial entity
type: Class
subclass of: independent continuant
BFO OWL specification label: immaterial
BFO CLIF specification label: ImmaterialEntity
editor note: BFO 2 Reference: Immaterial entities are divided into two subgroups:boundaries and sites, which bound, or are demarcated in relation, to material entities, and which can thus change location, shape and size and as their material hosts move or change shape or size (for example: your nasal passage; the hold of a ship; the boundary of Wales (which moves with the rotation of the Earth) [38, 7, 10

process profile
type: Class
subclass of: process
BFO OWL specification label: process-profile
BFO CLIF specification label: ProcessProfile
example of usage: On a somewhat higher level of complexity are what we shall call rate process profiles, which are the targets of selective abstraction focused not on determinate quality magnitudes plotted over time, but rather on certain ratios between these magnitudes and elapsed times. A speed process profile, for example, is represented by a graph plotting against time the ratio of distance covered per unit of time. Since rates may change, and since such changes, too, may have rates of change, we have to deal here with a hierarchy of process profile universals at successive levels
example of usage: One important sub-family of rate process profiles is illustrated by the beat or frequency profiles of cyclical processes, illustrated by the 60 beats per minute beating process of John’s heart, or the 120 beats per minute drumming process involved in one of John’s performances in a rock band, and so on. Each such process includes what we shall call a beat process profile instance as part, a subtype of rate process profile in which the salient ratio is not distance covered but rather number of beat cycles per unit of time. Each beat process profile instance instantiates the determinable universal beat process profile. But it also instantiates multiple more specialized universals at lower levels of generality, selected from rate process profilebeat process profileregular beat process profile3 bpm beat process profile4 bpm beat process profileirregular beat process profileincreasing beat process profileand so on.In the case of a regular beat process profile, a rate can be assigned in the simplest possible fashion by dividing the number of cycles by the length of the temporal region occupied by the beating process profile as a whole. Irregular process profiles of this sort, for example as identified in the clinic, or in the readings on an aircraft instrument panel, are often of diagnostic significance.
example of usage: The simplest type of process profiles are what we shall call ‘quality process profiles’, which are the process profiles which serve as the foci of the sort of selective abstraction that is involved when measurements are made of changes in single qualities, as illustrated, for example, by process profiles of mass, temperature, aortic pressure, and so on.
definition: b is a process_profile =Def. there is some process c such that b process_profile_of c (axiom label in BFO2 Reference: [093-002])
elucidation: b process_profile_of c holds when b proper_occurrent_part_of c& there is some proper_occurrent_part d of c which has no parts in common with b & is mutually dependent on b& is such that b, c and d occupy the same temporal region (axiom label in BFO2 Reference: [094-005])
has associated axiom(fol): (forall (x y) (if (processProfileOf x y) (and (properContinuantPartOf x y) (exists (z t) (and (properOccurrentPartOf z y) (TemporalRegion t) (occupiesSpatioTemporalRegion x t) (occupiesSpatioTemporalRegion y t) (occupiesSpatioTemporalRegion z t) (not (exists (w) (and (occurrentPartOf w x) (occurrentPartOf w z))))))))) // axiom label in BFO2 CLIF: [094-005]
has associated axiom(fol): (iff (ProcessProfile a) (exists (b) (and (Process b) (processProfileOf a b)))) // axiom label in BFO2 CLIF: [093-002]

Axiom
annotated source: process profile
annotated property: definition
annotated target: b is a process_profile =Def. there is some process c such that b process_profile_of c (axiom label in BFO2 Reference: [093-002])
IAO_0010000: http://purl.obolibrary.org/obo/bfo/axiom/093-002

Axiom
annotated source: process profile
annotated property: elucidation
annotated target: b process_profile_of c holds when b proper_occurrent_part_of c& there is some proper_occurrent_part d of c which has no parts in common with b & is mutually dependent on b& is such that b, c and d occupy the same temporal region (axiom label in BFO2 Reference: [094-005])
IAO_0010000: http://purl.obolibrary.org/obo/bfo/axiom/094-005

Axiom
annotated source: process profile
annotated property: has associated axiom(fol)
annotated target: (forall (x y) (if (processProfileOf x y) (and (properContinuantPartOf x y) (exists (z t) (and (properOccurrentPartOf z y) (TemporalRegion t) (occupiesSpatioTemporalRegion x t) (occupiesSpatioTemporalRegion y t) (occupiesSpatioTemporalRegion z t) (not (exists (w) (and (occurrentPartOf w x) (occurrentPartOf w z))))))))) // axiom label in BFO2 CLIF: [094-005]
IAO_0010000: http://purl.obolibrary.org/obo/bfo/axiom/094-005

Axiom
annotated source: process profile
annotated property: has associated axiom(fol)
annotated target: (iff (ProcessProfile a) (exists (b) (and (Process b) (processProfileOf a b)))) // axiom label in BFO2 CLIF: [093-002]
IAO_0010000: http://purl.obolibrary.org/obo/bfo/axiom/093-002

fentanyl
type: Class
subclass of: anilide
subclass of: piperidines
subclass of: monocarboxylic acid amide
subclass of: opioid analgesic
subclass of: Restriction
  on property: has role
  some values from: psychoactive substance
has curation status: External
definition: A monocarboxylic acid amide resulting from the formal condensation of the aryl amino group of N-phenyl-1-(2-phenylethyl)piperidin-4-amine with propanoic acid.
definition source: CHEBI:119915
has_alternative_id: CHEBI:310077
has_alternative_id: CHEBI:5012
has_obo_namespace: chebi_ontology
id: CHEBI:119915
in_subset: 3 STAR

atomoxetine
type: Class
subclass of: toluenes
subclass of: aromatic ether
subclass of: secondary amino compound
subclass of: Restriction
  on property: has role
  some values from: antidepressant
has curation status: External
definition: A secondary amino compound having methyl and 3-(2-methylphenoxy)-3-phenylpropan-1-yl substituents.
definition source: CHEBI:127342
has_obo_namespace: chebi_ontology
id: CHEBI:127342
in_subset: 3 STAR

anilide
type: Class
subclass of: benzenes
subclass of: aromatic amide
definition: Any aromatic amide obtained by acylation of aniline.
has_obo_namespace: chebi_ontology
id: CHEBI:13248
in_subset: 3 STAR

volatile organic compound
type: Class
subclass of: organic molecule
definition: Any organic compound having an initial boiling point less than or equal to 250 degreeC (482 degreeF) measured at a standard atmospheric pressure of 101.3 kPa.
has_obo_namespace: chebi_ontology
id: CHEBI:134179
in_subset: 3 STAR

gas molecular entity
type: Class
subclass of: main group molecular entity
definition: Any main group molecular entity that is gaseous at standard temperature and pressure (STP; 0degreeC and 100 kPa).
has_obo_namespace: chebi_ontology
id: CHEBI:138675
in_subset: 3 STAR

3,4-methylenedioxymethamphetamine
type: Class
subclass of: amphetamines
subclass of: benzodioxoles
definition: A member of the class of benzodioxoles that is 1,3-benzodioxole substituted by a 2-(methylamino)propyl group at position 5.
has_obo_namespace: chebi_ontology
id: CHEBI:1391
in_subset: 3 STAR

primary alcohol
type: Class
subclass of: alcohol
definition: A primary alcohol is a compound in which a hydroxy group, -OH, is attached to a saturated carbon atom which has either three hydrogen atoms attached to it or only one other carbon atom and two hydrogen atoms attached to it.
has_alternative_id: CHEBI:13676
has_alternative_id: CHEBI:14887
has_alternative_id: CHEBI:26262
has_alternative_id: CHEBI:57489
has_alternative_id: CHEBI:8406
has_obo_namespace: chebi_ontology
id: CHEBI:15734
in_subset: 3 STAR

ethanol
type: Class
subclass of: volatile organic compound
subclass of: ethanols
subclass of: alkyl alcohol
has curation status: External
definition: A primary alcohol that is ethane in which one of the hydrogens is substituted by a hydroxy group.
alternative term: alcohol
definition source: CHEBI:16236
has_alternative_id: CHEBI:14222
has_alternative_id: CHEBI:23978
has_alternative_id: CHEBI:30878
has_alternative_id: CHEBI:30880
has_alternative_id: CHEBI:42377
has_alternative_id: CHEBI:44594
has_alternative_id: CHEBI:4879
has_obo_namespace: chebi_ontology
id: CHEBI:16236
in_subset: 3 STAR

naphthalene
type: Class
subclass of: naphthalenes
subclass of: ortho-fused bicyclic arene
has curation status: External
definition: An aromatic hydrocarbon comprising two fused benzene rings. It occurs in the essential oils of numerous plant species e.g. magnolia.
definition source: CHEBI:16482
has_alternative_id: CHEBI:14638
has_alternative_id: CHEBI:25469
has_alternative_id: CHEBI:44619
has_alternative_id: CHEBI:7472
has_obo_namespace: chebi_ontology
id: CHEBI:16482
in_subset: 3 STAR

codeine
type: Class
subclass of: morphinane alkaloid
subclass of: organic heteropentacyclic compound
definition: A morphinane alkaloid found in the opium poppy, Papaver somniferum var. album; has analgesic, anti-tussive and anti-diarrhoeal properties.
has_alternative_id: CHEBI:14006
has_alternative_id: CHEBI:23348
has_alternative_id: CHEBI:3803
has_obo_namespace: chebi_ontology
id: CHEBI:16714
in_subset: 3 STAR

formaldehyde
type: Class
subclass of: aldehyde
subclass of: one-carbon compound
has curation status: External
definition: An aldehyde resulting from the formal oxidation of methanol.
definition source: CHEBI:16842
has_alternative_id: CHEBI:14274
has_alternative_id: CHEBI:24077
has_alternative_id: CHEBI:337763
has_alternative_id: CHEBI:5142
has_obo_namespace: chebi_ontology
id: CHEBI:16842
in_subset: 3 STAR

ketone
type: Class
subclass of: carbonyl compound
definition: A compound in which a carbonyl group is bonded to two carbon atoms: R2C=O (neither R may be H).
has_alternative_id: CHEBI:13427
has_alternative_id: CHEBI:13646
has_alternative_id: CHEBI:24974
has_alternative_id: CHEBI:6127
has_alternative_id: CHEBI:8742
has_obo_namespace: chebi_ontology
id: CHEBI:17087
in_subset: 3 STAR

propanal
type: Class
subclass of: propanals
subclass of: alpha-CH2-containing aldehyde
has curation status: External
definition: An aldehyde that consists of ethane bearing a formyl substituent. The parent of the class of propanals.
alternative term: propionaldehyde
definition source: CHEBI:17153
has_alternative_id: CHEBI:14898
has_alternative_id: CHEBI:26281
has_alternative_id: CHEBI:41359
has_alternative_id: CHEBI:45052
has_alternative_id: CHEBI:8468
has_obo_namespace: chebi_ontology
id: CHEBI:17153
in_subset: 3 STAR

carbon monoxide
type: Class
subclass of: gas molecular entity
subclass of: carbon oxide
subclass of: one-carbon compound
has curation status: External
definition: A one-carbon compound in which the carbon is joined only to a single oxygen. It is a colourless, odourless, tasteless, toxic gas.
alternative term: CO
definition source: CHEBI:17245
has_alternative_id: CHEBI:13281
has_alternative_id: CHEBI:23013
has_alternative_id: CHEBI:3282
has_alternative_id: CHEBI:41526
has_obo_namespace: chebi_ontology
id: CHEBI:17245
in_subset: 3 STAR

aldehyde
type: Class
subclass of: carbonyl compound
definition: A compound RC(=O)H, in which a carbonyl group is bonded to one hydrogen atom and to one R group.
has_alternative_id: CHEBI:13432
has_alternative_id: CHEBI:13753
has_alternative_id: CHEBI:13805
has_alternative_id: CHEBI:13806
has_alternative_id: CHEBI:22291
has_alternative_id: CHEBI:2554
has_alternative_id: CHEBI:8750
has_obo_namespace: chebi_ontology
id: CHEBI:17478
in_subset: 3 STAR

methanol
type: Class
subclass of: volatile organic compound
subclass of: primary alcohol
subclass of: alkyl alcohol
subclass of: one-carbon compound
subclass of: Restriction
  on property: has role
  some values from: psychoactive substance
has curation status: External
definition: The primary alcohol that is the simplest aliphatic alcohol, comprising a methyl and an alcohol group.
has_alternative_id: CHEBI:14588
has_alternative_id: CHEBI:25227
has_alternative_id: CHEBI:44080
has_alternative_id: CHEBI:44553
has_alternative_id: CHEBI:6816
has_obo_namespace: chebi_ontology
id: CHEBI:17790
in_subset: 3 STAR

organohalogen compound
type: Class
subclass of: heteroorganic entity
subclass of: halide
definition: A compound containing at least one carbon-halogen bond (where X is a halogen atom).
has_alternative_id: CHEBI:13444
has_alternative_id: CHEBI:36684
has_alternative_id: CHEBI:8767
has_obo_namespace: chebi_ontology
id: CHEBI:17792
in_subset: 3 STAR

lipid
type: Class
subclass of: organic molecular entity
definition: 'Lipids' is a loosely defined term for substances of biological origin that are soluble in nonpolar solvents. They consist of saponifiable lipids, such as glycerides (fats and oils) and phospholipids, as well as nonsaponifiable lipids, principally steroids.
has_alternative_id: CHEBI:14517
has_alternative_id: CHEBI:25054
has_alternative_id: CHEBI:6486
has_obo_namespace: chebi_ontology
id: CHEBI:18059
in_subset: 3 STAR

nicotine
type: Class
subclass of: racemate
subclass of: Restriction
  on property: has role
  some values from: psychoactive substance
has curation status: External
definition: A racemate composed of equimolar amounts of (R)- and (S)-nicotine.
definition source: CHEBI:18723
has_obo_namespace: chebi_ontology
id: CHEBI:18723
in_subset: 3 STAR

acetyl-amino acid
type: Class
subclass of: amino-acid derivative
definition: Any amino acid derivative that is the N-acetyl or O-acetyl derivative of an amino acid.
has_obo_namespace: chebi_ontology
id: CHEBI:22195
in_subset: 3 STAR

acetylcysteine
type: Class
subclass of: acetyl-amino acid
subclass of: cysteine derivative
has curation status: External
definition: A metabolite of acrolein and may be found in the urine of smokers.
alternative term: 3-HPMA
definition source: NCIT:C107144
curator note: Not in CHEBI and not wanting to import the full information from NCIT.
has_obo_namespace: chebi_ontology
id: CHEBI:22198
in_subset: 3 STAR

alkaloid
type: Class
subclass of: organonitrogen compound
definition: Any of the naturally occurring, basic nitrogen compounds (mostly heterocyclic) occurring mostly in the plant kingdom, but also found in bacteria, fungi, and animals. By extension, certain neutral compounds biogenetically related to basic alkaloids are also classed as alkaloids. Amino acids, peptides, proteins, nucleotides, nucleic acids, amino sugars and antibiotics are not normally regarded as alkaloids. Compounds in which the nitrogen is exocyclic (dopamine, mescaline, serotonin, etc.) are usually classed as amines rather than alkaloids.
has_obo_namespace: chebi_ontology
id: CHEBI:22315
in_subset: 3 STAR

benzenes
type: Class
subclass of: benzenoid aromatic compound
definition: Any benzenoid aromatic compound consisting of the benzene skeleton and its substituted derivatives.
has_obo_namespace: chebi_ontology
id: CHEBI:22712
in_subset: 3 STAR

benzodiazepine
type: Class
subclass of: organonitrogen heterocyclic compound
subclass of: organic heteropolycyclic compound
subclass of: Restriction
  on property: has role
  some values from: anxiolytic drug
has curation status: External
definition: A group of heterocyclic compounds with a core structure containing a benzene ring fused to a diazepine ring.
definition: An organic heteropolycyclic compound that has a core structure containing a benzene ring fused to a diazepine ring.
alternative term: Benzos
definition source: CHEBI:22720
has_obo_namespace: chebi_ontology
id: CHEBI:22720
in_subset: 3 STAR

cadmium molecular entity
type: Class
subclass of: zinc group molecular entity
has_obo_namespace: chebi_ontology
id: CHEBI:22978
in_subset: 3 STAR

carbon oxide
type: Class
subclass of: organic oxide
subclass of: organooxygen compound
has_obo_namespace: chebi_ontology
id: CHEBI:23014
in_subset: 3 STAR

chlorine molecular entity
type: Class
subclass of: halogen molecular entity
definition: A halogen molecular entity containing one or more atoms of chlorine.
has_obo_namespace: chebi_ontology
id: CHEBI:23117
in_subset: 3 STAR

chlorobenzenes
type: Class
subclass of: benzenes
subclass of: organochlorine compound
definition: Any organochlorine compound containing a benzene ring which is substituted by one or more chlorines.
has_obo_namespace: chebi_ontology
id: CHEBI:23132
in_subset: 3 STAR

molecular entity
type: Class
subclass of: chemical entity
definition: Any constitutionally or isotopically distinct atom, molecule, ion, ion pair, radical, radical ion, complex, conformer etc., identifiable as a separately distinguishable entity.
has_obo_namespace: chebi_ontology
id: CHEBI:23367
in_subset: 3 STAR

cyclic amide
type: Class
subclass of: amide
has_alternative_id: CHEBI:3990
has_obo_namespace: chebi_ontology
id: CHEBI:23443
in_subset: 3 STAR

cysteine derivative
type: Class
subclass of: amino-acid derivative
definition: An amino acid derivative resulting from reaction of cysteine at the amino group, carboxy group, or thiol group, or from the replacement of any hydrogen of cysteine by a heteroatom. The definition normally excludes peptides containing cysteine residues.
has_alternative_id: CHEBI:25309
has_obo_namespace: chebi_ontology
id: CHEBI:23509
in_subset: 3 STAR

diazole
type: Class
subclass of: azole
definition: An azole that is either one of a pair of heterocyclic organic compounds comprising three carbon atoms and two nitrogen atoms arranged in a ring.
has_obo_namespace: chebi_ontology
id: CHEBI:23677
in_subset: 3 STAR

dichlorobenzene
type: Class
subclass of: chlorobenzenes
definition: Any member of the class of chlorobenzenes carrying two chloro groups at unspecified positions.
has_obo_namespace: chebi_ontology
id: CHEBI:23697
in_subset: 3 STAR

quinolone
type: Class
subclass of: quinolines
has_obo_namespace: chebi_ontology
id: CHEBI:23765
in_subset: 3 STAR

diterpenoid
type: Class
subclass of: terpenoid
definition: Any terpenoid derived from a diterpene. The term includes compounds in which the C20 skeleton of the parent diterpene has been rearranged or modified by the removal of one or more skeletal atoms (generally methyl groups).
has_obo_namespace: chebi_ontology
id: CHEBI:23849
in_subset: 3 STAR

drug
type: Class
subclass of: pharmaceutical
subclass of: Restriction
  on property: has role
  some values from: drug role
has curation status: External
definition: Any substance which when absorbed into a living organism may modify one or more of its functions. The term is generally accepted for a substance taken for a therapeutic purpose, but is also commonly used for abused substances.
has_obo_namespace: chebi_ontology
id: CHEBI:23888
in_subset: 3 STAR
label: drug role

enzyme inhibitor
type: Class
subclass of: inhibitor
subclass of: biochemical role
definition: A compound or agent that combines with an enzyme in such a manner as to prevent the normal substrate-enzyme combination and the catalytic reaction.
has_obo_namespace: chebi_ontology
id: CHEBI:23924
in_subset: 3 STAR

ethanols
type: Class
subclass of: primary alcohol
definition: Any primary alcohol based on an ethanol skeleton.
has_obo_namespace: chebi_ontology
id: CHEBI:23982
in_subset: 3 STAR

chemical entity
type: Class
subclass of: material entity
has curation status: External
definition: A chemical entity is a physical entity of interest in chemistry including molecular entities, parts thereof, and chemical substances.
definition: A physical entity of interest in chemistry including molecular entities, parts thereof, and chemical substances.
has_obo_namespace: chebi_ontology
id: CHEBI:24431
in_subset: 3 STAR

biological role
type: Class
subclass of: chemical realizable
definition: A role played by the molecular entity or part thereof within a biological context.
has_obo_namespace: chebi_ontology
id: CHEBI:24432
in_subset: 3 STAR

halogen molecular entity
type: Class
subclass of: p-block molecular entity
has_obo_namespace: chebi_ontology
id: CHEBI:24471
in_subset: 3 STAR

organic heterocyclic compound
type: Class
subclass of: heteroorganic entity
subclass of: organic cyclic compound
subclass of: heterocyclic compound
definition: A cyclic compound having as ring members atoms of carbon and at least of one other element.
has_obo_namespace: chebi_ontology
id: CHEBI:24532
in_subset: 3 STAR

hydrocarbon
type: Class
subclass of: organic fundamental parent
definition: A compound consisting of carbon and hydrogen only.
has_obo_namespace: chebi_ontology
id: CHEBI:24632
in_subset: 3 STAR

hydroxides
type: Class
subclass of: oxygen molecular entity
subclass of: hydrogen molecular entity
subclass of: heteroatomic molecular entity
definition: Hydroxides are chemical compounds containing a hydroxy group or salts containing hydroxide (OH(-)).
has_obo_namespace: chebi_ontology
id: CHEBI:24651
in_subset: 3 STAR

oxoacid
type: Class
subclass of: hydroxides
definition: A compound which contains oxygen, at least one other element, and at least one hydrogen bound to oxygen, and which produces a conjugate base by loss of positive hydrogen ion(s) (hydrons).
has_obo_namespace: chebi_ontology
id: CHEBI:24833
in_subset: 3 STAR

isoprenoid
type: Class
subclass of: lipid
definition: Any lipid formally derived from isoprene (2-methylbuta-1,3-diene), the skeleton of which can generally be discerned in repeated occurrence in the molecule. The skeleton of isoprenoids may differ from strict additivity of isoprene units by loss or shift of a fragment, commonly a methyl group. The class includes both hydrocarbons and oxygenated derivatives.
has_obo_namespace: chebi_ontology
id: CHEBI:24913
in_subset: 3 STAR

isoquinoline alkaloid
type: Class
subclass of: alkaloid
definition: Any alkaloid that has a structure based on an isoquinoline nucleus. They are derived from the amino acids like tyrosine and phenylalanine.
has_obo_namespace: chebi_ontology
id: CHEBI:24921
in_subset: 3 STAR

lactam
type: Class
subclass of: cyclic amide
subclass of: carboxamide
subclass of: organonitrogen heterocyclic compound
definition: Cyclic amides of amino carboxylic acids, having a 1-azacycloalkan-2-one structure, or analogues having unsaturation or heteroatoms replacing one or more carbon atoms of the ring.
has_obo_namespace: chebi_ontology
id: CHEBI:24995
in_subset: 3 STAR

methyl ester
type: Class
subclass of: carboxylic ester
definition: Any carboxylic ester resulting from the formal condensation of a carboxy group with methanol.
has_obo_namespace: chebi_ontology
id: CHEBI:25248
in_subset: 3 STAR

methylxanthine
type: Class
subclass of: purine alkaloid
has_obo_namespace: chebi_ontology
id: CHEBI:25348
in_subset: 3 STAR

molecule
type: Class
subclass of: polyatomic entity
definition: Any polyatomic entity that is an electrically neutral entity consisting of more than one atom.
has_obo_namespace: chebi_ontology
id: CHEBI:25367
in_subset: 3 STAR

monocarboxylic acid
type: Class
subclass of: carboxylic acid
definition: An oxoacid containing a single carboxy group.
has_obo_namespace: chebi_ontology
id: CHEBI:25384
in_subset: 3 STAR

morphinane alkaloid
type: Class
subclass of: isoquinoline alkaloid
definition: An isoquinoline alkaloid based on a morphinan skeleton and its substituted derivatives.
has_obo_namespace: chebi_ontology
id: CHEBI:25418
in_subset: 3 STAR

naphthalenes
type: Class
subclass of: benzenoid aromatic compound
subclass of: carbobicyclic compound
definition: Any benzenoid aromatic compound having a skeleton composed of two ortho-fused benzene rings.
has_obo_namespace: chebi_ontology
id: CHEBI:25477
in_subset: 3 STAR

organic heteromonocyclic compound
type: Class
subclass of: organic heterocyclic compound
subclass of: heteromonocyclic compound
has_obo_namespace: chebi_ontology
id: CHEBI:25693
in_subset: 3 STAR

ether
type: Class
subclass of: organooxygen compound
definition: An organooxygen compound with formula ROR, where R is not hydrogen.
has_obo_namespace: chebi_ontology
id: CHEBI:25698
in_subset: 3 STAR

organic oxide
type: Class
subclass of: oxide
subclass of: organic molecule
definition: An oxide in which the oxygen atom is bonded to a carbon atom.
has_obo_namespace: chebi_ontology
id: CHEBI:25701
in_subset: 3 STAR

aliphatic alcohol
type: Class
subclass of: alcohol
definition: An alcohol derived from an aliphatic compound.
has_obo_namespace: chebi_ontology
id: CHEBI:2571
in_subset: 3 STAR

oxide
type: Class
subclass of: oxygen molecular entity
subclass of: heteroatomic molecular entity
definition: An oxide is a chemical compound of oxygen with other chemical elements.
has_obo_namespace: chebi_ontology
id: CHEBI:25741
in_subset: 3 STAR

oxygen molecular entity
type: Class
subclass of: chalcogen molecular entity
has_obo_namespace: chebi_ontology
id: CHEBI:25806
in_subset: 3 STAR

piperazines
type: Class
subclass of: organic heteromonocyclic compound
subclass of: organonitrogen heterocyclic compound
has_obo_namespace: chebi_ontology
id: CHEBI:26144
in_subset: 3 STAR

piperidines
type: Class
subclass of: organic heteromonocyclic compound
subclass of: organonitrogen heterocyclic compound
has_obo_namespace: chebi_ontology
id: CHEBI:26151
in_subset: 3 STAR

polyketide
type: Class
subclass of: organooxygen compound
definition: Natural and synthetic compounds containing alternating carbonyl and methylene groups ('beta-polyketones'), biogenetically derived from repeated condensation of acetyl coenzyme A (via malonyl coenzyme A), and usually the compounds derived from them by further condensations, etc. Considered by many to be synonymous with the less frequently used terms acetogenins and ketides.
has_obo_namespace: chebi_ontology
id: CHEBI:26188
in_subset: 3 STAR

propanals
type: Class
subclass of: aldehyde
definition: An aldehyde based on a propanal skeleton and its derivatives.
has_obo_namespace: chebi_ontology
id: CHEBI:26282
in_subset: 3 STAR

purine alkaloid
type: Class
subclass of: alkaloid
subclass of: purines
has_obo_namespace: chebi_ontology
id: CHEBI:26385
in_subset: 3 STAR

purines
type: Class
subclass of: imidazopyrimidine
definition: A class of imidazopyrimidines that consists of purine and its substituted derivatives.
has_alternative_id: CHEBI:13678
has_obo_namespace: chebi_ontology
id: CHEBI:26401
in_subset: 3 STAR

pyrazoles
type: Class
subclass of: diazole
has_obo_namespace: chebi_ontology
id: CHEBI:26410
in_subset: 3 STAR

pyridines
type: Class
subclass of: organic heteromonocyclic compound
subclass of: organonitrogen heterocyclic compound
definition: Any organonitrogen heterocyclic compound based on a pyridine skeleton and its substituted derivatives.
has_obo_namespace: chebi_ontology
id: CHEBI:26421
in_subset: 3 STAR

pyrrolidine alkaloid
type: Class
subclass of: alkaloid
subclass of: pyrrolidines
has_obo_namespace: chebi_ontology
id: CHEBI:26456
in_subset: 3 STAR

quinolines
type: Class
subclass of: organic aromatic compound
subclass of: organonitrogen heterocyclic compound
definition: A class of aromatic heterocyclic compounds each of which contains a benzene ring ortho fused to carbons 2 and 3 of a pyridine ring.
has_obo_namespace: chebi_ontology
id: CHEBI:26513
in_subset: 3 STAR

amphetamine
type: Class
subclass of: amphetamines
subclass of: racemate
subclass of: Restriction
  on property: has role
  some values from: psychoactive substance
has curation status: External
definition: A racemate comprising equimolar amounts of (R)-amphetamine (also known as levamphetamine or levoamphetamine) and (S)-amphetamine (also known as dexamfetamine or dextroamphetamine.
definition: A racemate comprising equimolar amounts of (R)-amphetamine (also known as levamphetamine or levoamphetamine) and (S)-amphetamine (also known as dexamphetamine or dextroamphetamine.
definition source: CHEBI:2679
curator note: Note: ChEBI has two outgoing parents, racemate or amphetamines.
has_alternative_id: CHEBI:51062
has_obo_namespace: chebi_ontology
id: CHEBI:2679
in_subset: 3 STAR

terpenoid
type: Class
subclass of: isoprenoid
definition: Any isoprenoid that is a natural product or related compound formally derived from isoprene units. Terpenoids may contain oxygen in various functional groups. This class is subdivided according to the number of carbon atoms in the parent terpene. The skeleton of terpenoids may differ from strict additivity of isoprene units by the loss or shift of a fragment, generally a methyl group.
has_obo_namespace: chebi_ontology
id: CHEBI:26873
in_subset: 3 STAR

tertiary alcohol
type: Class
subclass of: alcohol
definition: A tertiary alcohol is a compound in which a hydroxy group, -OH, is attached to a saturated carbon atom which has three other carbon atoms attached to it.
has_obo_namespace: chebi_ontology
id: CHEBI:26878
in_subset: 3 STAR

organic heterotricyclic compound
type: Class
subclass of: heterotricyclic compound
subclass of: organic heteropolycyclic compound
subclass of: organic tricyclic compound
definition: An organic tricyclic compound in which at least one of the rings of the tricyclic skeleton contains one or more heteroatoms.
has_obo_namespace: chebi_ontology
id: CHEBI:26979
in_subset: 3 STAR

toluenes
type: Class
subclass of: benzenes
definition: Any member of the class of benzenes that is a substituted benzene in which the substituents include one (and only one) methyl group.
has_obo_namespace: chebi_ontology
id: CHEBI:27024
in_subset: 3 STAR

trimethylxanthine
type: Class
subclass of: methylxanthine
has_obo_namespace: chebi_ontology
id: CHEBI:27134
in_subset: 3 STAR

organic heterobicyclic compound
type: Class
subclass of: heterobicyclic compound
subclass of: organic heteropolycyclic compound
has_obo_namespace: chebi_ontology
id: CHEBI:27171
in_subset: 3 STAR

caffeine
type: Class
subclass of: trimethylxanthine
subclass of: Restriction
  on property: has role
  some values from: psychoactive substance
has curation status: External
definition: A trimethylxanthine in which the three methyl groups are located at positions 1, 3, and 7. A purine alkaloid that occurs naturally in tea and coffee.
definition source: CHEBI:27732
has_alternative_id: CHEBI:22982
has_alternative_id: CHEBI:3295
has_alternative_id: CHEBI:41472
has_obo_namespace: chebi_ontology
id: CHEBI:27732
in_subset: 3 STAR

heroin
type: Class
subclass of: morphinane alkaloid
subclass of: Restriction
  on property: has role
  some values from: psychoactive substance
has curation status: External
definition: A morphinane alkaloid that is morphine bearing two acetyl substituents on the O-3 and O-6 positions.
definition: A morphinane alkaloid that is morphine bearing two acetyl substituents on the O-3 and O-6 positions. As with other opioids, heroin is used as both an analgesic and a recreational drug. Frequent and regular administration is associated with tolerance and physical dependence, which may develop into addiction. Its use includes treatment for acute pain, such as in severe physical trauma, myocardial infarction, post-surgical pain, and chronic pain, including end-stage cancer and other terminal illnesses.
definition source: CHEBI:27808
has_alternative_id: CHEBI:24528
has_alternative_id: CHEBI:5680
has_obo_namespace: chebi_ontology
id: CHEBI:27808
in_subset: 3 STAR
comment: As with other opioids, heroin is used as both an analgesic and a recreational drug. Frequent and regular administration is associated with tolerance and physical dependence, which may develop into addiction. Its use includes treatment for acute pain, such as in severe physical trauma, myocardial infarction, post-surgical pain, and chronic pain, including end-stage cancer and other terminal illnesses.

cocaine
type: Class
subclass of: methyl ester
subclass of: benzoate ester
subclass of: tropane alkaloid
subclass of: tertiary amino compound
subclass of: Restriction
  on property: has role
  some values from: psychoactive substance
has curation status: External
definition: A tropane alkaloid obtained from leaves of the South American shrub Erythroxylon coca.
definition source: CHEBI:27958
has_alternative_id: CHEBI:23346
has_alternative_id: CHEBI:3801
has_alternative_id: CHEBI:41642
has_obo_namespace: chebi_ontology
id: CHEBI:27958
in_subset: 3 STAR

monocarboxylic acid amide
type: Class
subclass of: carboxamide
definition: A carboxamide derived from a monocarboxylic acid.
has_alternative_id: CHEBI:13211
has_alternative_id: CHEBI:22207
has_alternative_id: CHEBI:25383
has_alternative_id: CHEBI:6977
has_obo_namespace: chebi_ontology
id: CHEBI:29347
in_subset: 3 STAR

baclofen
type: Class
subclass of: monocarboxylic acid
subclass of: gamma-amino acid
subclass of: primary amino compound
subclass of: monochlorobenzenes
has curation status: External
definition: A monocarboxylic acid that is butanoic acid substituted by an amino group at position 4 and a 4-chlorophenyl group at position 3.
definition: A monocarboxylic acid that is butanoic acid substituted by an amino group at position 4 and a 4-chlorophenyl group at position 3. It acts as a central nervous system depressant, GABA agonist and muscle relaxant.
definition source: CHEBI:2972
has_obo_namespace: chebi_ontology
id: CHEBI:2972
in_subset: 3 STAR
comment: It acts as a central nervous system depressant, GABA agonist and muscle relaxant.

alcohol
type: Class
subclass of: organic hydroxy compound
definition: A compound in which a hydroxy group, -OH, is attached to a saturated carbon atom.
has_alternative_id: CHEBI:13804
has_alternative_id: CHEBI:22288
has_alternative_id: CHEBI:2553
has_obo_namespace: chebi_ontology
id: CHEBI:30879
in_subset: 3 STAR

aripiprazole
type: Class
subclass of: dichlorobenzene
subclass of: quinolone
subclass of: aromatic ether
subclass of: N-alkylpiperazine
subclass of: N-arylpiperazine
subclass of: delta-lactam
subclass of: Restriction
  on property: has role
  some values from: second generation antipsychotic
has curation status: External
definition: An N-arylpiperazine that is piperazine substituted by a 4-[(2-oxo-1,2,3,4-tetrahydroquinolin-7-yl)oxy]butyl group at position 1 and by a 2,3-dichlorophenyl group at position 4. It is an antipsychotic drug used for the treatment of Schizophrenia, and other mood disorders.
alternative term: `
definition source: CHEBI:31236
has_obo_namespace: chebi_ontology
id: CHEBI:31236
in_subset: 3 STAR

buprenorphine
type: Class
subclass of: morphinane alkaloid
has curation status: External
definition: A morphinane alkaloid that is 7,8-dihydromorphine 6-O-methyl ether in which positions 6 and 14 are joined by a -CH2CH2- bridge, one of the hydrogens of the N-methyl group is substituted by cyclopropyl, and a hydrogen at position 7 is substituted by a 2-hydroxy-3,3-dimethylbutan-2-yl group. It is highly effective for the treatment of opioid use disorder and is also increasingly being used in the treatment of chronic pain.
definition: A morphinane alkaloid that is 7,8-dihydromorphine 6-O-methyl ether in which positions 6 and 14 are joined by a -CH2CH2- bridge, one of the hydrogens of the N-methyl group is substituted by cyclopropyl, and a hydrogen at position 7 is substituted by a 2-hydroxy-3,3-dimethylbutan-2-yl group. [RW: 'Morphine alkaloid ...?]
definition source: CHEBI:3216
has_alternative_id: CHEBI:143179
has_alternative_id: CHEBI:166254
has_alternative_id: CHEBI:453763
has_alternative_id: CHEBI:489640
has_alternative_id: CHEBI:656608
has_obo_namespace: chebi_ontology
id: CHEBI:3216
in_subset: 3 STAR

bupropion
type: Class
subclass of: secondary amino compound
subclass of: aromatic ketone
subclass of: monochlorobenzenes
subclass of: Restriction
  on property: has role
  some values from: antidepressant
has curation status: External
definition: An aromatic ketone that is propiophenone carrying a tert-butylamino group at position 2 and a chloro substituent at position 3 on the phenyl ring.
definition source: CHEBI:3219
has_obo_namespace: chebi_ontology
id: CHEBI:3219
in_subset: 3 STAR
comment: It is a medication primarily used to treat major depressive disorder and to support stopping smoking.

4-(N-nitrosomethylamino)-1-(3-pyridyl)butan-1-one
type: Class
subclass of: pyridines
subclass of: nitrosamine
has curation status: External
definition: 4-(N-nitrosomethylamino)-1-(3-pyridyl)butan-1-one (CHEBI:32692) is a nitrosamine (CHEBI:35803).
definition: A nitrosamine that has formula C10H13N3O2.
alternative term: NNK
definition source: CHEBI:32692
has_obo_namespace: chebi_ontology
id: CHEBI:32692
in_subset: 3 STAR

secondary amine
type: Class
subclass of: amine
subclass of: secondary amino compound
definition: A compound formally derived from ammonia by replacing two hydrogen atoms by hydrocarbyl groups.
has_alternative_id: CHEBI:26618
has_alternative_id: CHEBI:9078
has_obo_namespace: chebi_ontology
id: CHEBI:32863
in_subset: 3 STAR

amine
type: Class
subclass of: organic amino compound
definition: A compound formally derived from ammonia by replacing one, two or three hydrogen atoms by hydrocarbyl groups.
has_alternative_id: CHEBI:13814
has_alternative_id: CHEBI:22474
has_alternative_id: CHEBI:2641
has_obo_namespace: chebi_ontology
id: CHEBI:32952
in_subset: 3 STAR

amide
type: Class
subclass of: nitrogen molecular entity
definition: An amide is a derivative of an oxoacid RkE(=O)l(OH)m (l =/= 0) in which an acidic hydroxy group has been replaced by an amino or substituted amino group.
has_alternative_id: CHEBI:22473
has_alternative_id: CHEBI:2633
has_obo_namespace: chebi_ontology
id: CHEBI:32988
in_subset: 3 STAR

application
type: Class
subclass of: chemical realizable
definition: Intended use of the molecular entity or part thereof by humans.
has_obo_namespace: chebi_ontology
id: CHEBI:33232
in_subset: 3 STAR

organic fundamental parent
type: Class
subclass of: organic hydride
subclass of: organic molecular entity
definition: An organic fundamental parent is a structure used as a basis for substitutive names in organic nomenclature, containing, in addition to one or more hydrogen atoms, a single atom of an element, a number of atoms (alike or different) linked together to form an unbranched chain, a monocyclic or polycyclic ring system, or a ring assembly or ring/chain system.
has_obo_namespace: chebi_ontology
id: CHEBI:33245
in_subset: 3 STAR

primary amide
type: Class
subclass of: amide
definition: A derivative of an oxoacid RkE(=O)l(OH)m (l =/= 0) in which an acidic hydroxy group has been replaced by an amino or substituted amino group.
has_obo_namespace: chebi_ontology
id: CHEBI:33256
in_subset: 3 STAR

heteroorganic entity
type: Class
subclass of: organic molecular entity
definition: A heteroorganic entity is an organic molecular entity in which carbon atoms or organic groups are bonded directly to one or more heteroatoms.
has_obo_namespace: chebi_ontology
id: CHEBI:33285
in_subset: 3 STAR

pnictogen molecular entity
type: Class
subclass of: p-block molecular entity
definition: A p-block molecular entity containing any pnictogen.
has_obo_namespace: chebi_ontology
id: CHEBI:33302
in_subset: 3 STAR

chalcogen molecular entity
type: Class
subclass of: p-block molecular entity
definition: Any p-block molecular entity containing a chalcogen.
has_obo_namespace: chebi_ontology
id: CHEBI:33304
in_subset: 3 STAR

carboxylic ester
type: Class
subclass of: ester
subclass of: carbonyl compound
definition: An ester of a carboxylic acid, R(1)C(=O)OR(2), where R(1) = H or organyl and R(2) = organyl.
has_alternative_id: CHEBI:13204
has_alternative_id: CHEBI:23028
has_alternative_id: CHEBI:3408
has_obo_namespace: chebi_ontology
id: CHEBI:33308
in_subset: 3 STAR

transition element molecular entity
type: Class
subclass of: molecular entity
definition: A molecular entity containing one or more atoms of a transition element.
has_obo_namespace: chebi_ontology
id: CHEBI:33497
in_subset: 3 STAR

benzenediols
type: Class
subclass of: phenols
has_alternative_id: CHEBI:22705
has_alternative_id: CHEBI:22711
has_obo_namespace: chebi_ontology
id: CHEBI:33570
in_subset: 3 STAR

resorcinols
type: Class
subclass of: benzenediols
definition: Any benzenediol in which the two hydroxy groups are meta to one another.
has_obo_namespace: chebi_ontology
id: CHEBI:33572
in_subset: 3 STAR

carboxylic acid
type: Class
subclass of: carbon oxoacid
subclass of: carbonyl compound
subclass of: organic acid
definition: A carbon oxoacid acid carrying at least one -C(=O)OH group and having the structure RC(=O)OH, where R is any any monovalent functional group. Carboxylic acids are the most common type of organic acid.
has_alternative_id: CHEBI:13428
has_alternative_id: CHEBI:13627
has_alternative_id: CHEBI:23027
has_obo_namespace: chebi_ontology
id: CHEBI:33575
in_subset: 3 STAR

main group molecular entity
type: Class
subclass of: molecular entity
definition: A molecular entity containing one or more atoms from any of groups 1, 2, 13, 14, 15, 16, 17, and 18 of the periodic table.
has_obo_namespace: chebi_ontology
id: CHEBI:33579
in_subset: 3 STAR

carbon group molecular entity
type: Class
subclass of: p-block molecular entity
has_obo_namespace: chebi_ontology
id: CHEBI:33582
in_subset: 3 STAR

cyclic compound
type: Class
subclass of: molecule
definition: Any molecule that consists of a series of atoms joined together to form a ring.
has_obo_namespace: chebi_ontology
id: CHEBI:33595
in_subset: 3 STAR

homocyclic compound
type: Class
subclass of: cyclic compound
definition: A cyclic compound having as ring members atoms of the same element only.
has_obo_namespace: chebi_ontology
id: CHEBI:33597
in_subset: 3 STAR

carbocyclic compound
type: Class
subclass of: homocyclic compound
subclass of: organic cyclic compound
definition: A homocyclic compound in which all of the ring members are carbon atoms.
has_obo_namespace: chebi_ontology
id: CHEBI:33598
in_subset: 3 STAR

hydrogen molecular entity
type: Class
subclass of: s-block molecular entity
has_obo_namespace: chebi_ontology
id: CHEBI:33608
in_subset: 3 STAR

polycyclic compound
type: Class
subclass of: cyclic compound
has_obo_namespace: chebi_ontology
id: CHEBI:33635
in_subset: 3 STAR

bicyclic compound
type: Class
subclass of: cyclic compound
definition: A molecule that features two fused rings.
has_obo_namespace: chebi_ontology
id: CHEBI:33636
in_subset: 3 STAR

ortho-fused compound
type: Class
subclass of: fused compound
definition: A polycyclic compound in which two rings have two, and only two, atoms in common. Such compounds have n common faces and 2n common atoms.
has_obo_namespace: chebi_ontology
id: CHEBI:33637
in_subset: 3 STAR

ortho- and peri-fused compound
type: Class
subclass of: fused compound
definition: A polycyclic compound in which one ring contains two, and only two, atoms in common with each of two or more rings of a contiguous series of rings. Such compounds have n common faces and less than 2n common atoms.
has_obo_namespace: chebi_ontology
id: CHEBI:33639
in_subset: 3 STAR

aromatic compound
type: Class
subclass of: cyclic compound
definition: A cyclically conjugated molecular entity with a stability (due to delocalization) significantly greater than that of a hypothetical localized structure (e.g. Kekule structure) is said to possess aromatic character.
has_obo_namespace: chebi_ontology
id: CHEBI:33655
in_subset: 3 STAR

arene
type: Class
subclass of: organic aromatic compound
subclass of: cyclic hydrocarbon
definition: Any monocyclic or polycyclic aromatic hydrocarbon.
has_obo_namespace: chebi_ontology
id: CHEBI:33658
in_subset: 3 STAR

organic aromatic compound
type: Class
subclass of: aromatic compound
subclass of: organic cyclic compound
has_obo_namespace: chebi_ontology
id: CHEBI:33659
in_subset: 3 STAR

monocyclic compound
type: Class
subclass of: cyclic compound
has_obo_namespace: chebi_ontology
id: CHEBI:33661
in_subset: 3 STAR

cyclic hydrocarbon
type: Class
subclass of: hydrocarbon
subclass of: carbocyclic compound
has_obo_namespace: chebi_ontology
id: CHEBI:33663
in_subset: 3 STAR

polycyclic hydrocarbon
type: Class
subclass of: cyclic hydrocarbon
subclass of: carbopolycyclic compound
has_obo_namespace: chebi_ontology
id: CHEBI:33666
in_subset: 3 STAR

heteromonocyclic compound
type: Class
subclass of: monocyclic compound
subclass of: heterocyclic compound
has_obo_namespace: chebi_ontology
id: CHEBI:33670
in_subset: 3 STAR

heteropolycyclic compound
type: Class
subclass of: polycyclic compound
subclass of: heterocyclic compound
definition: A polycyclic compound in which at least one of the rings contains at least one non-carbon atom.
has_obo_namespace: chebi_ontology
id: CHEBI:33671
in_subset: 3 STAR

heterobicyclic compound
type: Class
subclass of: bicyclic compound
subclass of: heterocyclic compound
definition: A bicyclic compound in which at least one of the rings contains at least one skeletal heteroatom.
has_obo_namespace: chebi_ontology
id: CHEBI:33672
in_subset: 3 STAR

zinc group molecular entity
type: Class
subclass of: d-block molecular entity
has_obo_namespace: chebi_ontology
id: CHEBI:33673
in_subset: 3 STAR

s-block molecular entity
type: Class
subclass of: main group molecular entity
definition: An s-block molecular entity is a molecular entity containing one or more atoms of an s-block element.
has_obo_namespace: chebi_ontology
id: CHEBI:33674
in_subset: 3 STAR

p-block molecular entity
type: Class
subclass of: main group molecular entity
definition: A main group molecular entity that contains one or more atoms of a p-block element.
has_obo_namespace: chebi_ontology
id: CHEBI:33675
in_subset: 3 STAR

d-block molecular entity
type: Class
subclass of: transition element molecular entity
definition: A d-block molecular entity is a molecular entity containing one or more atoms of a d-block element.
has_obo_namespace: chebi_ontology
id: CHEBI:33676
in_subset: 3 STAR

hydrides
type: Class
subclass of: hydrogen molecular entity
subclass of: heteroatomic molecular entity
definition: Hydrides are chemical compounds of hydrogen with other chemical elements.
has_obo_namespace: chebi_ontology
id: CHEBI:33692
in_subset: 3 STAR

gamma-amino acid
type: Class
subclass of: non-proteinogenic amino acid
definition: A non-proteinogenic amino-acid in which the amino group is located on the carbon atom at the position gamma to the carboxy group.
has_obo_namespace: chebi_ontology
id: CHEBI:33707
in_subset: 3 STAR

amino acid
type: Class
subclass of: carboxylic acid
subclass of: organic amino compound
definition: A carboxylic acid containing one or more amino groups.
has_alternative_id: CHEBI:13815
has_alternative_id: CHEBI:22477
has_obo_namespace: chebi_ontology
id: CHEBI:33709
in_subset: 3 STAR

organic hydroxy compound
type: Class
subclass of: hydroxides
subclass of: organic molecular entity
definition: An organic compound having at least one hydroxy group attached to a carbon atom.
has_alternative_id: CHEBI:64710
has_obo_namespace: chebi_ontology
id: CHEBI:33822
in_subset: 3 STAR

organic cyclic compound
type: Class
subclass of: cyclic compound
subclass of: organic molecule
definition: Any organic molecule that consists of atoms connected in the form of a ring.
has_obo_namespace: chebi_ontology
id: CHEBI:33832
in_subset: 3 STAR

heteroarene
type: Class
subclass of: organic heterocyclic compound
subclass of: organic aromatic compound
definition: A heterocyclic compound formally derived from an arene by replacement of one or more methine (-C=) and/or vinylene (-CH=CH-) groups by trivalent or divalent heteroatoms, respectively, in such a way as to maintain the continuous pi-electron system characteristic of aromatic systems and a number of out-of-plane pi-electrons corresponding to the Hueckel rule (4n+2).
has_obo_namespace: chebi_ontology
id: CHEBI:33833
in_subset: 3 STAR

benzenoid aromatic compound
type: Class
subclass of: carbocyclic compound
subclass of: organic aromatic compound
has_obo_namespace: chebi_ontology
id: CHEBI:33836
in_subset: 3 STAR

polycyclic arene
type: Class
subclass of: arene
subclass of: polycyclic hydrocarbon
definition: A polycyclic aromatic hydrocarbon.
has_obo_namespace: chebi_ontology
id: CHEBI:33848
in_subset: 3 STAR

phenols
type: Class
subclass of: organic aromatic compound
subclass of: organic hydroxy compound
definition: Organic aromatic compounds having one or more hydroxy groups attached to a benzene or other arene ring.
has_alternative_id: CHEBI:13664
has_alternative_id: CHEBI:13825
has_alternative_id: CHEBI:25969
has_alternative_id: CHEBI:2857
has_obo_namespace: chebi_ontology
id: CHEBI:33853
in_subset: 3 STAR

aromatic amine
type: Class
subclass of: organic aromatic compound
subclass of: organic amino compound
definition: An amino compound in which the amino group is linked directly to an aromatic system.
has_alternative_id: CHEBI:13827
has_alternative_id: CHEBI:22622
has_alternative_id: CHEBI:22646
has_alternative_id: CHEBI:2834
has_alternative_id: CHEBI:2863
has_obo_namespace: chebi_ontology
id: CHEBI:33860
in_subset: 3 STAR

rimonabant
type: Class
subclass of: dichlorobenzene
subclass of: pyrazoles
subclass of: carbohydrazide
subclass of: amidopiperidine
subclass of: monochlorobenzenes
has curation status: External
definition: A carbohydrazide obtained by formal condensation of the carboxy group of 5-(4-chlorophenyl)-1-(2,4-dichlorophenyl)-4-methyl-1H-pyrazole-3-carboxylic acid with the amino group of 1-aminopiperidine. It is a potent and selective cannabinoid receptor 1 (CB1R) antagonist. Besides its antagonistic properties, numerous studies have shown that, at micromolar concentrations rimonabant behaves as an inverse agonist at CB1 receptors. The drug was the first selective CB1 antagonist/inverse agonist introduced into clinical practice to treat obesity and metabolic-related disorders. It was later withdrawn from market due to CNS-related adverse effects including depression and suicidal ideation.
definition source: CHEBI:34967
has_obo_namespace: chebi_ontology
id: CHEBI:34967
in_subset: 3 STAR

inhibitor
type: Class
subclass of: biological role
definition: A substance that diminishes the rate of a chemical reaction.
has_obo_namespace: chebi_ontology
id: CHEBI:35222
in_subset: 3 STAR

fused compound
type: Class
subclass of: polycyclic compound
definition: A polycyclic compound that contains more than one ring with at least two common atoms (also known as bridgehead carbons) that are adjacent to each other.
has_obo_namespace: chebi_ontology
id: CHEBI:35293
in_subset: 3 STAR

carbopolycyclic compound
type: Class
subclass of: carbocyclic compound
subclass of: homopolycyclic compound
definition: A polyclic compound in which all of the ring members are carbon atoms.
has_obo_namespace: chebi_ontology
id: CHEBI:35294
in_subset: 3 STAR

homopolycyclic compound
type: Class
subclass of: homocyclic compound
subclass of: polycyclic compound
has_obo_namespace: chebi_ontology
id: CHEBI:35295
in_subset: 3 STAR

ortho-fused polycyclic arene
type: Class
subclass of: polycyclic arene
subclass of: ortho-fused polycyclic hydrocarbon
has_obo_namespace: chebi_ontology
id: CHEBI:35296
in_subset: 3 STAR

ortho- and peri-fused polycyclic arene
type: Class
subclass of: ortho- and peri-fused compound
subclass of: polycyclic arene
has_obo_namespace: chebi_ontology
id: CHEBI:35300
in_subset: 3 STAR

amphetamines
type: Class
subclass of: amine
definition: Amines that constitute a class of central nervous system stimulants based on the structure of the parent amphetamine 1-phenylpropan-2-amine.
has_obo_namespace: chebi_ontology
id: CHEBI:35338
in_subset: 3 STAR

organonitrogen compound
type: Class
subclass of: heteroorganic entity
subclass of: nitrogen molecular entity
definition: Any heteroorganic entity containing at least one carbon-nitrogen bond.
has_obo_namespace: chebi_ontology
id: CHEBI:35352
in_subset: 3 STAR

hydrazide
type: Class
subclass of: nitrogen molecular entity
definition: Compounds derived from oxoacids RkE(=O)l(OH)m (l =/= 0) by replacing -OH by -NRNR2 (R groups are commonly H). (IUPAC).
has_obo_namespace: chebi_ontology
id: CHEBI:35362
in_subset: 3 STAR

carbohydrazide
type: Class
subclass of: organonitrogen compound
subclass of: hydrazide
definition: A hydrazide consisting of hydrazine carrying one or more carboacyl groups.
has_obo_namespace: chebi_ontology
id: CHEBI:35363
in_subset: 3 STAR

ortho-fused bicyclic arene
type: Class
subclass of: ortho-fused polycyclic arene
subclass of: ortho-fused bicyclic hydrocarbon
has_obo_namespace: chebi_ontology
id: CHEBI:35426
in_subset: 3 STAR

ortho-fused polycyclic hydrocarbon
type: Class
subclass of: ortho-fused compound
has_obo_namespace: chebi_ontology
id: CHEBI:35427
in_subset: 3 STAR

ortho-fused bicyclic hydrocarbon
type: Class
subclass of: ortho-fused compound
subclass of: carbobicyclic compound
has_obo_namespace: chebi_ontology
id: CHEBI:35428
in_subset: 3 STAR

antidepressant
type: Class
subclass of: psychoactive drug
definition: Antidepressants are mood-stimulating drugs used primarily in the treatment of affective disorders and related conditions.
has_obo_namespace: chebi_ontology
id: CHEBI:35469
in_subset: 3 STAR

central nervous system drug
type: Class
subclass of: drug
has curation status: External
definition: A class of drugs producing both physiological and psychological effects through a variety of mechanisms involving the central nervous system.
has_obo_namespace: chebi_ontology
id: CHEBI:35470
in_subset: 3 STAR

psychoactive drug
type: Class
subclass of: central nervous system drug
has curation status: External
definition: A loosely defined grouping of drugs that have effects on psychological function.
definition source: CHEBI:35471
has_obo_namespace: chebi_ontology
id: CHEBI:35471
in_subset: 3 STAR
label: psychotropic drug

tranquilizing drug
type: Class
subclass of: psychoactive drug
subclass of: central nervous system depressant
subclass of: Restriction
  on property: has role
  some values from: psychoactive substance
has curation status: External
definition: A traditional grouping of drugs said to have a soothing or calming effect on mood, thought or behaviour.
alternative term: sedative drug
has_obo_namespace: chebi_ontology
id: CHEBI:35473
in_subset: 3 STAR

anxiolytic drug
type: Class
subclass of: tranquilizing drug
definition: Anxiolytic drugs are agents that alleviate anxiety, tension, and anxiety disorders, promote sedation, and have a calming effect without affecting clarity of consciousness or neurologic conditions.
has_obo_namespace: chebi_ontology
id: CHEBI:35474
in_subset: 3 STAR

antipsychotic agent
type: Class
subclass of: psychoactive substance
subclass of: tranquilizing drug
has curation status: External
definition: A psychoactive substance that is used to treat psychosis.
definition: Antipsychotic drugs are agents that control agitated psychotic behaviour, alleviate acute psychotic states, reduce psychotic symptoms, and exert a quieting effect.
has_obo_namespace: chebi_ontology
id: CHEBI:35476
in_subset: 3 STAR

antimanic drug
type: Class
subclass of: tranquilizing drug
definition: Antimanic drugs are agents used to treat bipolar disorders or mania associated with other affective disorders.
has_obo_namespace: chebi_ontology
id: CHEBI:35477
in_subset: 3 STAR

analgesic
type: Class
subclass of: drug
subclass of: pharmacological role
definition: An agent capable of relieving pain without the loss of consciousness or without producing anaesthesia. In addition, analgesic is a role played by a compound which is exhibited by a capability to cause a reduction of pain symptoms.
has_obo_namespace: chebi_ontology
id: CHEBI:35480
in_subset: 3 STAR

opioid analgesic
type: Class
subclass of: analgesic
has curation status: External
definition: A narcotic or opioid substance, synthetic or semisynthetic agent producing profound analgesia, drowsiness, and changes in mood.
alternative term: opioid
definition source: CHEBI:35482
has_obo_namespace: chebi_ontology
id: CHEBI:35482
in_subset: 3 STAR

central nervous system depressant
type: Class
subclass of: central nervous system drug
has curation status: External
definition: A loosely defined group of drugs that tend to reduce the activity of the central nervous system.
definition source: CHEBI:35488
has_obo_namespace: chebi_ontology
id: CHEBI:35488
in_subset: 3 STAR

1,4-benzodiazepinone
type: Class
subclass of: benzodiazepine
has_obo_namespace: chebi_ontology
id: CHEBI:35500
in_subset: 3 STAR

carbon oxoacid
type: Class
subclass of: oxoacid
subclass of: organooxygen compound
has_obo_namespace: chebi_ontology
id: CHEBI:35605
in_subset: 3 STAR

flavouring agent
type: Class
subclass of: food additive
definition: A food additive that is used to added improve the taste or odour of a food.
has_obo_namespace: chebi_ontology
id: CHEBI:35617
in_subset: 3 STAR

aromatic ether
type: Class
subclass of: ether
subclass of: organic aromatic compound
definition: Any ether in which the oxygen is attached to at least one aryl substituent.
has_obo_namespace: chebi_ontology
id: CHEBI:35618
in_subset: 3 STAR

secondary alcohol
type: Class
subclass of: alcohol
definition: A secondary alcohol is a compound in which a hydroxy group, -OH, is attached to a saturated carbon atom which has two other carbon atoms attached to it.
has_alternative_id: CHEBI:13425
has_alternative_id: CHEBI:13686
has_alternative_id: CHEBI:26617
has_alternative_id: CHEBI:58662
has_alternative_id: CHEBI:8741
has_alternative_id: CHEBI:9077
has_obo_namespace: chebi_ontology
id: CHEBI:35681
in_subset: 3 STAR

ester
type: Class
subclass of: organooxygen compound
definition: A compound formally derived from an oxoacid RkE(=O)l(OH)m (l > 0) and an alcohol, phenol, heteroarenol, or enol by linking with formal loss of water from an acidic hydroxy group of the former and a hydroxy group of the latter.
has_alternative_id: CHEBI:23960
has_alternative_id: CHEBI:4859
has_obo_namespace: chebi_ontology
id: CHEBI:35701
in_subset: 3 STAR

nitroso compound
type: Class
subclass of: nitrogen molecular entity
definition: Compounds having the nitroso group, -NO, attached to carbon, or to another element, most commonly nitrogen or oxygen.
has_obo_namespace: chebi_ontology
id: CHEBI:35800
in_subset: 3 STAR

nitrosamine
type: Class
subclass of: nitroso compound
definition: N-Nitroso amines, compounds of the structure R2NNO. Compounds RNHNO are not ordinarily isolable, but they, too, are nitrosamines. The name is a contraction of N-nitrosoamine and, as such, does not require the N locant.
has_obo_namespace: chebi_ontology
id: CHEBI:35803
in_subset: 3 STAR

imidazopyrimidine
type: Class
subclass of: organic heterobicyclic compound
subclass of: heteroarene
subclass of: organonitrogen heterocyclic compound
has_obo_namespace: chebi_ontology
id: CHEBI:35875
in_subset: 3 STAR

neurotransmitter agent
type: Class
subclass of: drug
subclass of: pharmacological role
definition: A substance used for its pharmacological action on any aspect of neurotransmitter systems. Neurotransmitter agents include agonists, antagonists, degradation inhibitors, uptake inhibitors, depleters, precursors, and modulators of receptor function.
has_obo_namespace: chebi_ontology
id: CHEBI:35942
in_subset: 3 STAR

bridged compound
type: Class
subclass of: polycyclic compound
definition: A polycyclic compound that contains more than one ring with at least two common atoms (also known as bridgehead carbons) that are not adjacent to each other.
has_obo_namespace: chebi_ontology
id: CHEBI:35990
in_subset: 3 STAR

benzoate ester
type: Class
subclass of: carboxylic ester
subclass of: aromatic ester
definition: Esters of benzoic acid or substituted benzoic acids.
has_obo_namespace: chebi_ontology
id: CHEBI:36054
in_subset: 3 STAR

polyatomic entity
type: Class
subclass of: molecular entity
definition: Any molecular entity consisting of more than one atom.
has_obo_namespace: chebi_ontology
id: CHEBI:36357
in_subset: 3 STAR

carbonyl compound
type: Class
subclass of: organic oxo compound
subclass of: organooxygen compound
has curation status: External
definition: Any compound containing the carbonyl group, C=O. The term is commonly used in the restricted sense of aldehydes and ketones, although it actually includes carboxylic acids and derivatives.
definition source: CHEBI:36586
curator note: Often the term 'carbonyl' is used alone, which actually refers to a range of different compounds.
has_obo_namespace: chebi_ontology
id: CHEBI:36586
in_subset: 3 STAR

organic oxo compound
type: Class
subclass of: organic molecule
definition: Organic compounds containing an oxygen atom, =O, doubly bonded to carbon or another element.
has_obo_namespace: chebi_ontology
id: CHEBI:36587
in_subset: 3 STAR

organochlorine compound
type: Class
subclass of: organohalogen compound
subclass of: chlorine molecular entity
definition: An organochlorine compound is a compound containing at least one carbon-chlorine bond.
has_obo_namespace: chebi_ontology
id: CHEBI:36683
in_subset: 3 STAR

heterotricyclic compound
type: Class
subclass of: heteropolycyclic compound
has_obo_namespace: chebi_ontology
id: CHEBI:36688
in_subset: 3 STAR

carbobicyclic compound
type: Class
subclass of: bicyclic compound
subclass of: carbopolycyclic compound
definition: A bicyclic compound in which all the ring atoms are carbon.
has_obo_namespace: chebi_ontology
id: CHEBI:36785
in_subset: 3 STAR

organochalcogen compound
type: Class
subclass of: heteroorganic entity
subclass of: chalcogen molecular entity
definition: An organochalcogen compound is a compound containing at least one carbon-chalcogen bond.
has_obo_namespace: chebi_ontology
id: CHEBI:36962
in_subset: 3 STAR

organooxygen compound
type: Class
subclass of: oxygen molecular entity
subclass of: organochalcogen compound
definition: An organochalcogen compound containing at least one carbon-oxygen bond.
has_obo_namespace: chebi_ontology
id: CHEBI:36963
in_subset: 3 STAR

organic hydride
type: Class
subclass of: hydrides
has_obo_namespace: chebi_ontology
id: CHEBI:37175
in_subset: 3 STAR

elemental cadmium
type: Class
subclass of: cadmium molecular entity
has curation status: External
definition: An element in the zinc group of the periodic table with atomic number 48, atomic mass 112, M.P. 321degreeC, and B.P. 765degreeC). An odourless, tasteless, and highly poisonous soft, ductile, lustrous metal with electropositive properties. It has eight stable isotopes: (106)Cd, (108)Cd,(110)Cd, (111)Cd, (112)Cd, (113)Cd, (114)Cd and (116)Cd, with (112)Cd and (114)Cd being the most common.
definition: An element in the zinc group of the periodic table with atomic number 48, atomic mass 112, M.P. 321°C, and B.P. 765°C). An odourless, tasteless, and highly poisonous soft, ductile, lustrous metal with electropositive properties. It has eight stable isotopes: 106Cd, 108Cd,110Cd, 111Cd, 112Cd, 113Cd, 114Cd and 116Cd, with 112Cd and 114Cd being the most common.
alternative term: cadmium
definition source: CHEBI:37249
has_obo_namespace: chebi_ontology
id: CHEBI:37249
in_subset: 3 STAR

tropane alkaloid
type: Class
subclass of: alkaloid
subclass of: azabicycloalkane
has_alternative_id: CHEBI:27154
has_alternative_id: CHEBI:27155
has_obo_namespace: chebi_ontology
id: CHEBI:37332
in_subset: 3 STAR

heteroatomic molecular entity
type: Class
subclass of: polyatomic entity
definition: A molecular entity consisting of two or more chemical elements.
has_obo_namespace: chebi_ontology
id: CHEBI:37577
in_subset: 3 STAR

halide
type: Class
subclass of: halogen molecular entity
subclass of: heteroatomic molecular entity
definition: Any heteroatomic molecular entity that is a chemical compound of halogen with other chemical elements.
has_obo_namespace: chebi_ontology
id: CHEBI:37578
in_subset: 3 STAR

carboxamide
type: Class
subclass of: primary amide
subclass of: organonitrogen compound
subclass of: organooxygen compound
definition: An amide of a carboxylic acid, having the structure RC(=O)NR2. The term is used as a suffix in systematic name formation to denote the -C(=O)NH2 group including its carbon atom.
has_alternative_id: CHEBI:35354
has_alternative_id: CHEBI:35355
has_obo_namespace: chebi_ontology
id: CHEBI:37622
in_subset: 3 STAR

organonitrogen heterocyclic compound
type: Class
subclass of: organic heterocyclic compound
subclass of: organonitrogen compound
definition: Any organonitrogen compound containing a cyclic component with nitrogen and at least one other element as ring member atoms.
has_obo_namespace: chebi_ontology
id: CHEBI:38101
in_subset: 3 STAR

oxacycle
type: Class
subclass of: organic heterocyclic compound
subclass of: organooxygen compound
definition: Any organic heterocyclic compound containing at least one ring oxygen atom.
has_obo_namespace: chebi_ontology
id: CHEBI:38104
in_subset: 3 STAR

organic heterotetracyclic compound
type: Class
subclass of: organic heteropolycyclic compound
has_obo_namespace: chebi_ontology
id: CHEBI:38163
in_subset: 3 STAR

organic heteropentacyclic compound
type: Class
subclass of: organic heteropolycyclic compound
has_obo_namespace: chebi_ontology
id: CHEBI:38164
in_subset: 3 STAR

organic heteropolycyclic compound
type: Class
subclass of: organic heterocyclic compound
subclass of: heteropolycyclic compound
has_alternative_id: CHEBI:25429
has_alternative_id: CHEBI:38075
has_obo_namespace: chebi_ontology
id: CHEBI:38166
in_subset: 3 STAR

monocyclic heteroarene
type: Class
subclass of: heteroarene
has_obo_namespace: chebi_ontology
id: CHEBI:38179
in_subset: 3 STAR

pyrrolidines
type: Class
subclass of: organic heteromonocyclic compound
subclass of: organonitrogen heterocyclic compound
definition: Any of a class of heterocyclic amines having a saturated five-membered ring.
has_alternative_id: CHEBI:26922
has_alternative_id: CHEBI:38191
has_obo_namespace: chebi_ontology
id: CHEBI:38260
in_subset: 3 STAR

pyrrolidinone
type: Class
subclass of: pyrrolidines
has_obo_namespace: chebi_ontology
id: CHEBI:38275
in_subset: 3 STAR

azabicycloalkane
type: Class
subclass of: organic heterobicyclic compound
subclass of: organonitrogen heterocyclic compound
has_obo_namespace: chebi_ontology
id: CHEBI:38295
in_subset: 3 STAR

benzodioxoles
type: Class
subclass of: organic heterobicyclic compound
subclass of: oxacycle
has_obo_namespace: chebi_ontology
id: CHEBI:38298
in_subset: 3 STAR

cholinergic drug
type: Class
subclass of: neurotransmitter agent
definition: Any drug used for its actions on cholinergic systems. Included here are agonists and antagonists, drugs that affect the life cycle of acetylcholine, and drugs that affect the survival of cholinergic neurons.
has_obo_namespace: chebi_ontology
id: CHEBI:38323
in_subset: 3 STAR

cholinergic agonist
type: Class
subclass of: cholinergic drug
definition: Any drug that binds to and activates cholinergic receptors.
has_obo_namespace: chebi_ontology
id: CHEBI:38324
in_subset: 3 STAR

benzochromene
type: Class
subclass of: organic heterotricyclic compound
subclass of: oxacycle
has_obo_namespace: chebi_ontology
id: CHEBI:38920
in_subset: 3 STAR

pyrene
type: Class
subclass of: ortho- and peri-fused polycyclic arene
has curation status: External
definition: An ortho- and peri-fused polycyclic arene consisting of four fused benzene rings, resulting in a flat aromatic system.
definition source: CHEBI:39106
has_alternative_id: CHEBI:29860
has_alternative_id: CHEBI:34940
has_obo_namespace: chebi_ontology
id: CHEBI:39106
in_subset: 3 STAR

cytisine
type: Class
subclass of: alkaloid
subclass of: lactam
subclass of: organic heterotricyclic compound
subclass of: bridged compound
subclass of: secondary amino compound
has curation status: External
definition: An organic heterotricyclic compound that is the toxic principle in Laburnum seeds and is found in many members of the Fabaceae (legume, pea or bean) family. An acetylcholine agonist, it is widely used throughout Eastern Europe as an aid to giving up smoking.
alternative term: baptitoxine and sophorine
definition source: CHEBI:4055
has_obo_namespace: chebi_ontology
id: CHEBI:4055
in_subset: 3 STAR

crotonaldehyde
type: Class
subclass of: enal
has curation status: External
definition: An enal consisting of propene having a formyl group at the 1-position.
definition source: CHEBI:41607
has_obo_namespace: chebi_ontology
id: CHEBI:41607
in_subset: 3 STAR

gabapentin
type: Class
subclass of: gamma-amino acid
has curation status: External
definition: A gamma-amino acid that is cyclohexane substituted at position 1 by aminomethyl and carboxymethyl groups. Used for treatment of neuropathic pain and restless legs syndrome.
definition: A γ-amino acid that is cyclohexane substituted at position 1 by aminomethyl and carboxymethyl groups. Used for treatment of neuropathic pain and restless legs syndrome.
definition source: CHEBI:42797
has_alternative_id: CHEBI:5237
has_obo_namespace: chebi_ontology
id: CHEBI:42797
in_subset: 3 STAR

N-alkylpyrrolidine
type: Class
subclass of: pyrrolidines
subclass of: tertiary amino compound
has_obo_namespace: chebi_ontology
id: CHEBI:46775
in_subset: 3 STAR

N-alkylpiperazine
type: Class
subclass of: piperazines
subclass of: tertiary amino compound
has_obo_namespace: chebi_ontology
id: CHEBI:46845
in_subset: 3 STAR

N-arylpiperazine
type: Class
subclass of: piperazines
subclass of: aromatic amine
subclass of: tertiary amino compound
has_obo_namespace: chebi_ontology
id: CHEBI:46848
in_subset: 3 STAR

nicotinic acetylcholine receptor agonist
type: Class
subclass of: cholinergic agonist
has curation status: External
definition: An agonist that selectively binds to and activates a nicotinic acetylcholine receptor.
definition source: CHEBI:47958
has_alternative_id: CHEBI:82738
has_obo_namespace: chebi_ontology
id: CHEBI:47958
in_subset: 3 STAR

amidopiperidine
type: Class
subclass of: piperidines
subclass of: monocarboxylic acid amide
has_obo_namespace: chebi_ontology
id: CHEBI:48613
in_subset: 3 STAR

agonist
type: Class
subclass of: pharmacological role
definition: Substance which binds to cell receptors normally responding to naturally occurring substances and which produces a response of its own.
has_obo_namespace: chebi_ontology
id: CHEBI:48705
in_subset: 3 STAR

antagonist
type: Class
subclass of: pharmacological role
definition: Substance that attaches to and blocks cell receptors that normally bind naturally occurring substances.
has_obo_namespace: chebi_ontology
id: CHEBI:48706
in_subset: 3 STAR

cholinergic antagonist
type: Class
subclass of: cholinergic drug
definition: Any drug that binds to but does not activate cholinergic receptors, thereby blocking the actions of acetylcholine or cholinergic agonists.
has_obo_namespace: chebi_ontology
id: CHEBI:48873
in_subset: 3 STAR

nicotinic antagonist
type: Class
subclass of: cholinergic antagonist
has curation status: External
definition: An antagonist at the nicotinic cholinergic receptor.
alternative term: nicotinic acetylcholine receptor antagonist
definition source: CHEBI:48878
has_obo_namespace: chebi_ontology
id: CHEBI:48878
in_subset: 3 STAR

diazepam
type: Class
subclass of: 1,4-benzodiazepinone
subclass of: organochlorine compound
has curation status: External
definition: A 1,4-benzodiazepinone that is 1,3-dihydro-2H-1,4-benzodiazepin-2-one substituted by a chloro group at position 7, a methyl group at position 1 and a phenyl group at position 5.
definition source: CHEBI:49575
has_alternative_id: CHEBI:4494
has_alternative_id: CHEBI:49574
has_obo_namespace: chebi_ontology
id: CHEBI:49575
in_subset: 3 STAR

organic amino compound
type: Class
subclass of: organonitrogen compound
definition: A compound formally derived from ammonia by replacing one, two or three hydrogen atoms by organyl groups.
has_obo_namespace: chebi_ontology
id: CHEBI:50047
in_subset: 3 STAR

EC 1.1.1.1 (alcohol dehydrogenase) inhibitor
type: Class
subclass of: EC 1.1.1.* (oxidoreductase acting on donor CH-OH group, NAD(+) or NADP(+) acceptor) inhibitor
definition: An EC 1.1.1.* (oxidoreductase acting on donor CH-OH group, NAD(+) or NADP(+) acceptor) inhibitor that interferes with the action of alcohol dehydrogenase (EC 1.1.1.1).
has_obo_namespace: chebi_ontology
id: CHEBI:50269
in_subset: 3 STAR

alkyl alcohol
type: Class
subclass of: aliphatic alcohol
definition: An aliphatic alcohol in which the aliphatic alkane chain is substituted by a hydroxy group at unspecified position.
has_alternative_id: CHEBI:22937
has_alternative_id: CHEBI:50581
has_obo_namespace: chebi_ontology
id: CHEBI:50584
in_subset: 3 STAR

organic molecular entity
type: Class
subclass of: carbon group molecular entity
definition: Any molecular entity that contains carbon.
has_alternative_id: CHEBI:25700
has_alternative_id: CHEBI:33244
has_obo_namespace: chebi_ontology
id: CHEBI:50860
in_subset: 3 STAR

carcinogenic agent
type: Class
subclass of: aetiopathogenetic role
has curation status: External
definition: A role played by a chemical compound which is known to induce a process of carcinogenesis by corrupting normal cellular pathways, leading to the acquistion of tumoral capabilities.
definition: A role played by a chemical compound which is known to induce a process of carcinogenesis by corrupting normal cellular pathways, leading to the acquisition of tumoral capabilities.
alternative term: carcinogenicty
has_obo_namespace: chebi_ontology
id: CHEBI:50903
in_subset: 3 STAR

chemical realizable
type: Class
subclass of: realizable
definition: A role is particular behaviour which a material entity may exhibit.
has_obo_namespace: chebi_ontology
id: CHEBI:50906
in_subset: 3 STAR
label: role

primary amino compound
type: Class
subclass of: organic amino compound
definition: A compound formally derived from ammonia by replacing one hydrogen atom by an organyl group.
has_obo_namespace: chebi_ontology
id: CHEBI:50994
in_subset: 3 STAR

secondary amino compound
type: Class
subclass of: organic amino compound
definition: A compound formally derived from ammonia by replacing two hydrogen atoms by organyl groups.
has_obo_namespace: chebi_ontology
id: CHEBI:50995
in_subset: 3 STAR

tertiary amino compound
type: Class
subclass of: organic amino compound
definition: A compound formally derived from ammonia by replacing three hydrogen atoms by organyl groups.
has_obo_namespace: chebi_ontology
id: CHEBI:50996
in_subset: 3 STAR

nitrogen molecular entity
type: Class
subclass of: pnictogen molecular entity
has_alternative_id: CHEBI:25556
has_alternative_id: CHEBI:7594
has_obo_namespace: chebi_ontology
id: CHEBI:51143
in_subset: 3 STAR

antitussive
type: Class
subclass of: drug
definition: An agent that suppresses cough. Antitussives have a central or a peripheral action on the cough reflex, or a combination of both. Compare with expectorants, which are considered to increase the volume of secretions in the respiratory tract, so facilitating their removal by ciliary action and coughing, and mucolytics, which decrease the viscosity of mucus, facilitating its removal by ciliary action and expectoration.
has_obo_namespace: chebi_ontology
id: CHEBI:51177
in_subset: 3 STAR

cyclopropanes
type: Class
subclass of: carbocyclic compound
definition: Cyclopropane and its derivatives formed by substitution.
has_obo_namespace: chebi_ontology
id: CHEBI:51454
in_subset: 3 STAR

enal
type: Class
subclass of: alpha,beta-unsaturated aldehyde
subclass of: olefinic compound
definition: An alpha,beta-unsaturated aldehyde of general formula R(1)R(2)C=CR(3)-CH=O in which the aldehydic C=O function is conjugated to a C=C double bond at the alpha,beta position.
has_obo_namespace: chebi_ontology
id: CHEBI:51688
in_subset: 3 STAR

alpha,beta-unsaturated aldehyde
type: Class
subclass of: aldehyde
definition: An aldehyde of general formula R(1)R(2)C=CR(3)-CH=O or RC#C-CH=O in which the aldehydic C=O function is conjugated to an unsaturated C-C bond at the alpha,beta position.
has_obo_namespace: chebi_ontology
id: CHEBI:51718
in_subset: 3 STAR

organic polycyclic compound
type: Class
subclass of: polycyclic compound
subclass of: organic cyclic compound
has_obo_namespace: chebi_ontology
id: CHEBI:51958
in_subset: 3 STAR

organic tricyclic compound
type: Class
subclass of: organic polycyclic compound
has_obo_namespace: chebi_ontology
id: CHEBI:51959
in_subset: 3 STAR

biochemical role
type: Class
subclass of: biological role
definition: A biological role played by the molecular entity or part thereof within a biochemical context.
has_obo_namespace: chebi_ontology
id: CHEBI:52206
in_subset: 3 STAR

aetiopathogenetic role
type: Class
subclass of: biological role
definition: A role played by the molecular entity or part thereof which causes the development of a pathological process.
has_obo_namespace: chebi_ontology
id: CHEBI:52209
in_subset: 3 STAR

pharmacological role
type: Class
subclass of: biological role
definition: A biological role which describes how a drug interacts within a biological system and how the interactions affect its medicinal properties.
has_obo_namespace: chebi_ontology
id: CHEBI:52210
in_subset: 3 STAR

physiological role
type: Class
subclass of: biological role
has_obo_namespace: chebi_ontology
id: CHEBI:52211
in_subset: 1 STAR

pharmaceutical
type: Class
subclass of: application
has curation status: External
definition: A substance that is introduced into a living organism with therapeutic, diagnostic or hedonic purpose.
definition: Any substance introduced into a living organism with therapeutic or diagnostic purpose.
definition source: CHEBI:52217
has_alternative_id: CHEBI:33293
has_alternative_id: CHEBI:33294
has_obo_namespace: chebi_ontology
id: CHEBI:52217
in_subset: 3 STAR

heterocyclic compound
type: Class
subclass of: cyclic compound
definition: A cyclic compound having as ring members atoms of at least two different elements.
has_obo_namespace: chebi_ontology
id: CHEBI:5686
in_subset: 3 STAR

hydrocodone
type: Class
subclass of: organic heteropentacyclic compound
subclass of: morphinane-like compound
subclass of: Restriction
  on property: has role
  some values from: antitussive
has curation status: External
definition: A morphinane-like compound that is a semi-synthetic opioid synthesized from codeine.
definition source: CHEBI:5779
has_obo_namespace: chebi_ontology
id: CHEBI:5779
in_subset: 3 STAR

mephedrone
type: Class
subclass of: amphetamine
subclass of: secondary amino compound
subclass of: aromatic ketone
has curation status: External
definition: An aromatic ketone that is propiophenone substituted at C-4 and at C-beta with methyl and methylamino groups respectively. It is a synthetic stimulant and entactogen drug of the amphetamine and cathinone classes.
definition: An aromatic ketone that is propiophenone substituted at C-4 and at C-β with methyl and methylamino groups respectively. It is a synthetic stimulant and entactogen drug of the amphetamine and cathinone classes.
alternative term: white magic.
definition source: CHEBI:59331
has_obo_namespace: chebi_ontology
id: CHEBI:59331
in_subset: 3 STAR

chemical substance
type: Class
subclass of: chemical entity
has curation status: External
definition: A chemical substance is a portion of matter of constant composition, composed of molecular entities of the same type or of different types.
definition source: CHEBI:59999
has_obo_namespace: chebi_ontology
id: CHEBI:59999
in_subset: 3 STAR

mixture
type: Class
subclass of: chemical substance
definition: A mixture is a chemical substance composed of multiple molecules, at least two of which are of a different kind.
has_obo_namespace: chebi_ontology
id: CHEBI:60004
in_subset: 3 STAR

racemate
type: Class
subclass of: mixture
definition: A racemate is an equimolar mixture of a pair of enantiomers.
has_obo_namespace: chebi_ontology
id: CHEBI:60911
in_subset: 3 STAR

aromatic ester
type: Class
subclass of: organic aromatic compound
subclass of: ester
definition: An ester where the ester linkage is bonded directly to an aromatic system.
has_obo_namespace: chebi_ontology
id: CHEBI:62732
in_subset: 3 STAR

aromatic amide
type: Class
subclass of: amide
subclass of: organic aromatic compound
definition: An amide in which the amide linkage is bonded directly to an aromatic system.
has_obo_namespace: chebi_ontology
id: CHEBI:62733
in_subset: 3 STAR

food additive
type: Class
subclass of: application
subclass of: food component
definition: Any substance which is added to food to preserve or enhance its flavour and/or appearance.
has_obo_namespace: chebi_ontology
id: CHEBI:64047
in_subset: 3 STAR

one-carbon compound
type: Class
subclass of: organic molecular entity
definition: An organic molecular entity containing a single carbon atom (C1).
has_obo_namespace: chebi_ontology
id: CHEBI:64708
in_subset: 3 STAR

organic acid
type: Class
subclass of: organic molecular entity
definition: Any organic molecular entity that is acidic and contains carbon in covalent linkage.
has_obo_namespace: chebi_ontology
id: CHEBI:64709
in_subset: 3 STAR

second generation antipsychotic
type: Class
subclass of: antipsychotic agent
definition: Antipsychotic drugs which can have different modes of action but which tend to be less likely than first generation antipsychotics to cause extrapyramidal motor control disabilities such as body rigidity or Parkinson's disease-type movements.
has_obo_namespace: chebi_ontology
id: CHEBI:65191
in_subset: 3 STAR

Delta(9)-tetrahydrocannabinol
type: Class
subclass of: diterpenoid
subclass of: polyketide
subclass of: benzochromene
subclass of: phytocannabinoid
has curation status: External
definition: A diterpenoid that is 6a,7,8,10a-tetrahydro-6H-benzo[c]chromene substituted at position 1 by a hydroxy group, positions 6, 6 and 9 by methyl groups and at position 3 by a pentyl group.
definition: A diterpenoid that is 6a,7,8,10a-tetrahydro-6H-benzo[c]chromene substituted at position 1 by a hydroxy group, positions 6, 6 and 9 by methyl groups and at position 3 by a pentyl group. The principal psychoactive constituent of the cannabis plant, it is used for treatment of anorexia associated with AIDS as well as nausea and vomiting associated with cancer chemotherapy.
alternative term: THC
definition source: CHEBI:66964
has_alternative_id: CHEBI:4716
has_obo_namespace: chebi_ontology
id: CHEBI:66964
in_subset: 3 STAR
comment: ChEBI definition does not highlight use for recreational purposes. Sold illicitly. Users seek out for its psychoactive properties. CHEBI: The principal psychoactive constituent of the cannabis plant, it is used for treatment of anorexia associated with AIDS as well as nausea and vomiting associated with cancer chemotherapy.
label: THC

cannabinoid receptor agonist
type: Class
subclass of: agonist
has curation status: External
definition: An agonist that binds to and activates cannabinoid receptors.
definition source: CHEBI:67072
has_obo_namespace: chebi_ontology
id: CHEBI:67072
in_subset: 3 STAR

cannabinoid
type: Class
subclass of: organooxygen compound
has curation status: External
definition: A diverse group of pharmacologically active secondary metabolite characteristic to Cannabis plant as well as produced naturally in the body by humans and animals. Cannabinoids contain oxygen as a part of the heterocyclic ring or in the form of various functional groups. They are subdivided on the basis of their origin.
definition source: CHEBI:67194
has_obo_namespace: chebi_ontology
id: CHEBI:67194
in_subset: 3 STAR

phytocannabinoid
type: Class
subclass of: cannabinoid
definition: A class of cannabinoid which are C21 terpenophenolic compounds isolated primarily from Cannabis sativa.
has_obo_namespace: chebi_ontology
id: CHEBI:67196
in_subset: 3 STAR

synthetic cannabinoid
type: Class
subclass of: cannabinoid
has curation status: External
definition: A class of cannabinoid that consists of synthetic analogs of the naturally occuring cannabinoids.
definition: A class of cannabinoid that consists of synthetic analogs of the naturally occurring cannabinoids.
definition source: CHEBI:67201
has_obo_namespace: chebi_ontology
id: CHEBI:67201
in_subset: 3 STAR

methadone
type: Class
subclass of: ketone
subclass of: racemate
has curation status: External
definition: A ketone that is heptan-3-one substituted by a dimethylamino group at position 6 and two phenyl groups at position 4.
definition: A racemate comprising equimolar amounts of dextromethadone and levomethadone. It is a opioid analgesic which is used as a painkiller and as a substitute for heroin in the treatment of heroin addiction.
definition source: CHEBI:6807
has_obo_namespace: chebi_ontology
id: CHEBI:6807
in_subset: 3 STAR

methamphetamine
type: Class
subclass of: amphetamine
subclass of: secondary amine
has curation status: External
definition: A member of the class of amphetamines in which the amino group of (S)-amphetamine carries a methyl substituent.
definition source: CHEBI:6809
has_obo_namespace: chebi_ontology
id: CHEBI:6809
in_subset: 3 STAR

azole
type: Class
subclass of: organonitrogen heterocyclic compound
subclass of: monocyclic heteroarene
definition: Any monocyclic heteroarene consisting of a five-membered ring containing nitrogen. Azoles can also contain one or more other non-carbon atoms, such as nitrogen, sulfur or oxygen.
has_obo_namespace: chebi_ontology
id: CHEBI:68452
in_subset: 3 STAR

(-)-cotinine
type: Class
subclass of: pyridines
subclass of: pyrrolidine alkaloid
subclass of: N-alkylpyrrolidine
subclass of: pyrrolidin-2-ones
definition: An N-alkylpyrrolidine that consists of N-methylpyrrolidinone bearing a pyridin-3-yl substituent at position C-5 (the 5S-enantiomer). It is an alkaloid commonly found in Nicotiana tabacum.
has_obo_namespace: chebi_ontology
id: CHEBI:68641
in_subset: 3 STAR

cannabidiol
type: Class
subclass of: resorcinols
subclass of: phytocannabinoid
subclass of: olefinic compound
has curation status: External
definition: A cannabinoid that is cyclohexene which is substituted by a methyl group at position 1, a 2,6-dihydroxy-4-pentylphenyl group at position 3, and a prop-1-en-2-yl group at position 4.
definition: An cannabinoid that is cyclohexene which is substituted by a methyl group at position 1, a 2,6-dihydroxy-4-pentylphenyl group at position 3, and a prop-1-en-2-yl group at position 4.
alternative term: CBD
definition source: CHEBI:69478
has_alternative_id: CHEBI:3358
has_obo_namespace: chebi_ontology
id: CHEBI:69478
in_subset: 3 STAR

semisynthetic derivative
type: Class
subclass of: organic molecular entity
definition: Any organic molecular entity derived from a natural product by partial chemical synthesis.
has_obo_namespace: chebi_ontology
id: CHEBI:72588
in_subset: 3 STAR

organic molecule
type: Class
subclass of: molecule
subclass of: organic molecular entity
definition: Any molecule that consists of at least one carbon atom as part of the electrically neutral entity.
has_obo_namespace: chebi_ontology
id: CHEBI:72695
in_subset: 3 STAR

alpha-CH2-containing aldehyde
type: Class
subclass of: aldehyde
definition: An aldehyde of general formula R-CH2-CH=O in which the aldehydic C=O function is attached to a CH2 group at the alpha-position.
has_alternative_id: CHEBI:77661
has_obo_namespace: chebi_ontology
id: CHEBI:73359
in_subset: 3 STAR

cannabinoid receptor antagonist
type: Class
subclass of: antagonist
definition: An antagonist that binds to and deactivates cannabinoid receptors.
has_obo_namespace: chebi_ontology
id: CHEBI:73413
in_subset: 3 STAR

CB1 receptor antagonist
type: Class
subclass of: cannabinoid receptor antagonist
has curation status: External
definition: An antagonist that binds to and deactivates type 1 cannabinoid receptors.
definition source: CHEBI:73416
has_obo_namespace: chebi_ontology
id: CHEBI:73416
in_subset: 3 STAR

CB2 receptor antagonist
type: Class
subclass of: cannabinoid receptor antagonist
definition: An antagonist that binds to and deactivates type 2 cannabinoid receptors.
has_obo_namespace: chebi_ontology
id: CHEBI:73417
in_subset: 3 STAR

gamma-lactam
type: Class
subclass of: lactam
definition: A lactam in which the amide bond is contained within a five-membered ring, which includes the amide nitrogen and the carbonyl carbon.
has_obo_namespace: chebi_ontology
id: CHEBI:74222
in_subset: 3 STAR

pyrrolidin-2-ones
type: Class
subclass of: pyrrolidinone
subclass of: gamma-lactam
definition: A pyrrolidinone in which the oxo group is at position 2 of the pyrrolidine ring.
has_obo_namespace: chebi_ontology
id: CHEBI:74223
in_subset: 3 STAR

naloxone
type: Class
subclass of: morphinane alkaloid
subclass of: tertiary alcohol
subclass of: organic heteropentacyclic compound
has curation status: External
definition: A synthetic morphinane alkaloid that is morphinone in which the enone double bond has been reduced to a single bond, the hydrogen at position 14 has been replaced by a hydroxy group, and the methyl group attached to the nitrogen has been replaced by an allyl group.
definition: A synthetic morphinane alkaloid that is morphinone in which the enone double bond has been reduced to a single bond, the hydrogen at position 14 has been replaced by a hydroxy group, and the methyl group attached to the nitrogen has been replaced by an allyl group. A specific opioid antagonist, it is used (commonly as its hydrochloride salt) to reverse the effects of opioids, both following their use of opioids during surgery and in cases of known or suspected opioid overdose.
definition source: CHEBI:7459
has_obo_namespace: chebi_ontology
id: CHEBI:7459
in_subset: 3 STAR
comment: A specific opioid antagonist, it is used (commonly as its hydrochloride salt) to reverse the effects of opioids, both following their use of opioids during surgery and in cases of known or suspected opioid overdose.

naltrexone
type: Class
subclass of: organic heteropentacyclic compound
subclass of: cyclopropanes
subclass of: morphinane-like compound
has curation status: External
definition: An organic heteropentacyclic compound that is naloxone substituted in which the allyl group attached to the nitrogen is replaced by a cyclopropylmethyl group. A mu-opioid receptor antagonist, it is used to treat alcohol dependence.
definition: An organic heteropentacyclic compound that is naloxone substituted in which the allyl group attached to the nitrogen is replaced by a cyclopropylmethyl group.
definition source: CHEBI:7465
has_obo_namespace: chebi_ontology
id: CHEBI:7465
in_subset: 3 STAR
comment: A μ-opioid receptor antagonist, it is used to treat alcohol dependence.

aromatic ketone
type: Class
subclass of: ketone
definition: A ketone in which the carbonyl group is attached to an aromatic ring.
has_obo_namespace: chebi_ontology
id: CHEBI:76224
in_subset: 3 STAR

EC 1.* (oxidoreductase) inhibitor
type: Class
subclass of: enzyme inhibitor
definition: An enzyme inhibitor which interferes with the action of an oxidoreductase (EC 1.*.*.*).
has_obo_namespace: chebi_ontology
id: CHEBI:76725
in_subset: 3 STAR

EC 1.1.* (oxidoreductase acting on donor CH-OH group) inhibitor
type: Class
subclass of: EC 1.* (oxidoreductase) inhibitor
definition: An oxidoreductase inhibitor which interferes with the action of an oxidoreductase acting on the CH-OH group of donors (EC 1.1.*.*).
has_obo_namespace: chebi_ontology
id: CHEBI:76726
in_subset: 3 STAR

EC 1.1.1.* (oxidoreductase acting on donor CH-OH group, NAD(+) or NADP(+) acceptor) inhibitor
type: Class
subclass of: EC 1.1.* (oxidoreductase acting on donor CH-OH group) inhibitor
definition: An EC 1.1.* (oxidoreductase acting on donor CH-OH group) inhibitor that uses NAD(+) or NADP(+) as acceptor (EC 1.1.1.*).
has_obo_namespace: chebi_ontology
id: CHEBI:76835
in_subset: 3 STAR

delta-lactam
type: Class
subclass of: lactam
definition: A lactam in which the amide bond is contained within a six-membered ring, which includes the amide nitrogen and the carbonyl carbon.
has_obo_namespace: chebi_ontology
id: CHEBI:77727
in_subset: 3 STAR

food component
type: Class
subclass of: physiological role
definition: A physiological role played by any substance that is distributed in foodstuffs. It includes materials derived from plants or animals, such as vitamins or minerals, as well as environmental contaminants.
has_obo_namespace: chebi_ontology
id: CHEBI:78295
in_subset: 3 STAR

oxycodone
type: Class
subclass of: organic heteropentacyclic compound
subclass of: semisynthetic derivative
has curation status: External
definition: A semisynthetic opioid of formula C18H21NO4 that is derived from thebaine. It is a moderately potent opioid analgesic, generally used for relief of moderate to severe pain.
definition source: CHEBI:7852
has_obo_namespace: chebi_ontology
id: CHEBI:7852
in_subset: 3 STAR

olefinic compound
type: Class
subclass of: organic molecular entity
definition: Any organic molecular entity that contains at least one C=C bond.
has_obo_namespace: chebi_ontology
id: CHEBI:78840
in_subset: 3 STAR

4-(methylnitrosamino)-1-(3-pyridyl)-1-butanol
type: Class
subclass of: pyridines
subclass of: secondary alcohol
subclass of: nitrosamine
has curation status: External
definition: A member of the class of nitrosamines that is butan-1-ol substituted by a pyridin-3-yl group at position 1 and by a methyl(nitroso)amino group at position 4. It is a major metabolite of nitrosamine 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK), which is a carcinogen found in tobacco and responsible for inducing lung cancer in smokers.
alternative term: NNAL
definition source: CHEBI:82569
has_obo_namespace: chebi_ontology
id: CHEBI:82569
in_subset: 3 STAR

monochlorobenzenes
type: Class
subclass of: chlorobenzenes
definition: Any member of the class of chlorobenzenes containing a mono- or poly-substituted benzene ring in which only one substituent is chlorine.
has_obo_namespace: chebi_ontology
id: CHEBI:83403
in_subset: 3 STAR

morphinane-like compound
type: Class
subclass of: organonitrogen heterocyclic compound
definition: Any organonitrogen heterocyclic compound based on a morphinan skeleton. These are synthetic or semi-synthetic compounds that resemble the morphinane (opioid) alkaloids in their pharmacological effects.
has_obo_namespace: chebi_ontology
id: CHEBI:83818
in_subset: 3 STAR

non-proteinogenic amino acid
type: Class
subclass of: amino acid
definition: Any amino-acid that is not naturally encoded in the genetic code of any organism.
has_obo_namespace: chebi_ontology
id: CHEBI:83820
in_subset: 3 STAR

amino-acid derivative
type: Class
subclass of: organonitrogen compound
definition: Any derivative of an amino acid resulting from reaction at an amino group, carboxy group, side-chain functional group, or from the replacement of any hydrogen by a heteroatom. The definition normally excludes peptides containing amino acid residues.
has_alternative_id: CHEBI:25359
has_obo_namespace: chebi_ontology
id: CHEBI:83821
in_subset: 3 STAR

varenicline
type: Class
subclass of: bridged compound
subclass of: organic heterotetracyclic compound
subclass of: secondary amino compound
has curation status: External
definition: An organic heterotetracyclic compound that acts as a partial agonist for nicotinic cholinergic receptors and is used (in the form of its tartate salt) as an aid to giving up smoking.
definition source: CHEBI:84500
curator note: NB: ChEBI has two parents for Varenicline
has_obo_namespace: chebi_ontology
id: CHEBI:84500
in_subset: 3 STAR

separation method
type: Class
subclass of: material processing
definition: A method that results in the separation of two or more components according to some property.
has_alternative_id: FIX:0000002
has exact synonym: partition
id: CHMO:0000999

Axiom
annotated source: separation method
annotated property: definition
annotated target: A method that results in the separation of two or more components according to some property.
database_cross_reference: https://orcid.org/0000-0001-5985-7429

chromatography
type: Class
subclass of: separation method
definition: A separation method where the components are distributed between two phases, one of which is stationary, while the other moves in a definite direction.
has_alternative_id: FIX:0000053
has exact synonym: analytical chromatography
has exact synonym: chromatographic analysis
has exact synonym: preparative chromatography
id: CHMO:0001000

Axiom
annotated source: chromatography
annotated property: definition
annotated target: A separation method where the components are distributed between two phases, one of which is stationary, while the other moves in a definite direction.
database_cross_reference: https://doi.org/10.1351/goldbook.C01075

column chromatography
type: Class
subclass of: chromatography
definition: A chromatography method where the stationary bed is within a tube (of standard length 25 cm). The particles of the solid stationary phase or support coated with a liquid stationary phase may fill the whole inside volume of the tube (packed column) or be concentrated on or along the inside tube wall leaving an open, unrestricted path for the mobile phase in the middle part of the tube (open-tubular column).
has_alternative_id: CHMO:0002118
has_narrow_synonym: preparative column chromatography
id: CHMO:0001001

Axiom
annotated source: column chromatography
annotated property: definition
annotated target: A chromatography method where the stationary bed is within a tube (of standard length 25 cm). The particles of the solid stationary phase or support coated with a liquid stationary phase may fill the whole inside volume of the tube (packed column) or be concentrated on or along the inside tube wall leaving an open, unrestricted path for the mobile phase in the middle part of the tube (open-tubular column).
database_cross_reference: https://doi.org/10.1021/ac971247q
database_cross_reference: https://doi.org/10.1351/goldbook.C01182

liquid chromatography
type: Class
subclass of: column chromatography
has curation status: External
definition: Column chromatography where the mobile phase is a liquid
definition: Column chromatography where the mobile phase is a liquid.
has exact synonym: LC
id: CHMO:0001004

Axiom
annotated source: liquid chromatography
annotated property: definition
annotated target: Column chromatography where the mobile phase is a liquid.
database_cross_reference: FIX:0000608
database_cross_reference: https://orcid.org/0000-0001-5985-7429

disease by infectious agent
type: Class
subclass of: disease
definition: A disease that is the consequence of the presence of pathogenic microbial agents, including pathogenic viruses, pathogenic bacteria, fungi, protozoa, multicellular parasites, and aberrant proteins known as prions.
IEDB alternative term: infectious disease
has_alternative_id: DOID:10115
has_alternative_id: DOID:11078
has_alternative_id: DOID:1304
has_alternative_id: DOID:1321
has_alternative_id: DOID:2040
has_alternative_id: DOID:2288
has_alternative_id: DOID:3099
has_alternative_id: DOID:4120
has_alternative_id: DOID:4620
has_alternative_id: DOID:5256
has_alternative_id: DOID:945
has_alternative_id: DOID:95
has_alternative_id: DOID:9532
has_alternative_id: DOID:9696
database_cross_reference: ICD9CM:079.0
database_cross_reference: UMLS_CUI:C0001485
has exact synonym: infectious disease
has_obo_namespace: disease_ontology
id: DOID:0050117
in_subset: DO CFDE slim
in_subset: DO GXD slim
in_subset: DO MGI slim
in_subset: DO infectious disease slim
comment: DO:wk

Axiom
annotated source: disease by infectious agent
annotated property: definition
annotated target: A disease that is the consequence of the presence of pathogenic microbial agents, including pathogenic viruses, pathogenic bacteria, fungi, protozoa, multicellular parasites, and aberrant proteins known as prions.
type: ECO_0007636
database_cross_reference: url:https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C26726

primary bacterial infectious disease
type: Class
subclass of: bacterial infectious disease
definition: A bacterial infectious disease that results_in infection by bacteria as a result of their presence or activity within the normal, healthy host, and their intrinsic virulence is, in part, a necessary consequence of their need to reproduce and spread.
has_obo_namespace: disease_ontology
id: DOID:0050338
in_subset: DO FlyBase slim
in_subset: DO infectious disease slim

Axiom
annotated source: primary bacterial infectious disease
annotated property: definition
annotated target: A bacterial infectious disease that results_in infection by bacteria as a result of their presence or activity within the normal, healthy host, and their intrinsic virulence is, in part, a necessary consequence of their need to reproduce and spread.
type: ECO_0007638
database_cross_reference: url:http://en.wikipedia.org/wiki/Infectious_disease

alcohol-related birth defects
type: Class
subclass of: fetal alcohol spectrum disorder
has curation status: External
definition: A fetal alcohol spectrum disorder that results in damage to organs, bones, or muscles due to prenatal alcohol exposure.
has exact synonym: ARBD
has_obo_namespace: disease_ontology
id: DOID:0050668

Axiom
annotated source: alcohol-related birth defects
annotated property: definition
annotated target: A fetal alcohol spectrum disorder that results in damage to organs, bones, or muscles due to prenatal alcohol exposure.
type: ECO_0007637
database_cross_reference: url:http://www.cdc.gov/ncbddd/fasd/facts.html

Axiom
annotated source: alcohol-related birth defects
annotated property: has exact synonym
annotated target: ARBD
has synonym type: OMO_0003012

fetal alcohol spectrum disorder
type: Class
subclass of: specific developmental disorder
definition: A specific developmental disorder and physical disorder that is characterized by physical, behavioral and learning birth defects resulting from maternal ingestion of alcohol during pregnancy.
created by: lschriml
creation date: 2011-12-01T01:01:25Z
has_obo_namespace: disease_ontology
id: DOID:0050696

Axiom
annotated source: fetal alcohol spectrum disorder
annotated property: definition
annotated target: A specific developmental disorder and physical disorder that is characterized by physical, behavioral and learning birth defects resulting from maternal ingestion of alcohol during pregnancy.
type: ECO_0007637
type: ECO_0007638
database_cross_reference: url:http://en.wikipedia.org/wiki/Fetal_alcohol_spectrum_disorder
database_cross_reference: url:http://www.cdc.gov/ncbddd/fasd/facts.html

developmental disorder of mental health
type: Class
subclass of: disease of mental health
definition: A disease of mental health that occur during a child's developmental period between birth and age 18 resulting in retarding of the child's psychological or physical development.
has_obo_namespace: disease_ontology
id: DOID:0060037
in_subset: DO RAD slim

Axiom
annotated source: developmental disorder of mental health
annotated property: definition
annotated target: A disease of mental health that occur during a child's developmental period between birth and age 18 resulting in retarding of the child's psychological or physical development.
type: ECO_0007638
database_cross_reference: url:http://en.wikipedia.org/wiki/Developmental_disorders

specific developmental disorder
type: Class
subclass of: developmental disorder of mental health
definition: A developmental disorder of mental health that categorizes specific learning disabilities and developmental disorders affecting coordination.
has_obo_namespace: disease_ontology
id: DOID:0060038

Axiom
annotated source: specific developmental disorder
annotated property: definition
annotated target: A developmental disorder of mental health that categorizes specific learning disabilities and developmental disorders affecting coordination.
type: ECO_0007638
database_cross_reference: url:http://en.wikipedia.org/wiki/Specific_developmental_disorder

thrombosis
type: Class
subclass of: vascular disease
has curation status: External
definition: A vascular disease caused by the formation of a blood clot inside a blood vessel, obstructing the flow of blood through the circulatory system.
definition source: DOID:0060903
database_cross_reference: MESH:D013927
has_obo_namespace: disease_ontology
id: DOID:0060903

Axiom
annotated source: thrombosis
annotated property: definition
annotated target: A vascular disease caused by the formation of a blood clot inside a blood vessel, obstructing the flow of blood through the circulatory system.
type: ECO_0007638
database_cross_reference: url:https://en.wikipedia.org/wiki/Thrombosis

bacterial infectious disease
type: Class
subclass of: disease by infectious agent
definition: A disease by infectious agent that results_in infection, has_material_basis_in Bacteria.
database_cross_reference: ICD10CM:A49.9
database_cross_reference: MESH:D001424
database_cross_reference: NCI:C2890
database_cross_reference: SNOMEDCT_US_2023_03_01:87628006
database_cross_reference: UMLS_CUI:C0004623
has_obo_namespace: disease_ontology
id: DOID:104
in_subset: DO AGR slim
in_subset: DO FlyBase slim
in_subset: DO infectious disease slim
in_subset: NCIthesaurus

Axiom
annotated source: bacterial infectious disease
annotated property: definition
annotated target: A disease by infectious agent that results_in infection, has_material_basis_in Bacteria.
type: ECO_0007638
database_cross_reference: url:http://en.wikipedia.org/wiki/Pathogenic_bacteria

dissociative disorder
type: Class
subclass of: disease of mental health
has curation status: External
definition: A disease of mental health in which the normally well-integrated functions of memory, identity, perception, or consciousness are separated (dissociated).
definition: The essential feature of the Dissociative Disorders is a disruption in the usually integrated functions of consciousness, memory, identity, or perception. The disturbance may be sudden or gradual, transient or chronic.
has_alternative_id: DOID:4963
database_cross_reference: ICD10CM:F44.9
database_cross_reference: ICD10CM:F48.9
database_cross_reference: ICD9CM:300.15
database_cross_reference: ICD9CM:300.9
database_cross_reference: MESH:D004213
database_cross_reference: NCI:C92197
database_cross_reference: SNOMEDCT_US_2023_03_01:154883004
database_cross_reference: UMLS_CUI:C0012746
database_cross_reference: UMLS_CUI:C0041857
has exact synonym: dissociative disease
has exact synonym: dissociative reaction
has_obo_namespace: disease_ontology
id: DOID:10935
in_subset: NCIthesaurus

Axiom
annotated source: dissociative disorder
annotated property: definition
annotated target: A disease of mental health in which the normally well-integrated functions of memory, identity, perception, or consciousness are separated (dissociated).
database_cross_reference: url:https://www.mayoclinic.org/diseases-conditions/dissociative-disorders/symptoms-causes/syc-20355215

impulse control disorder
type: Class
subclass of: disease of mental health
has curation status: External
definition: A disease of mental health that involves a failure to resist an impulsive act or behaviour that may be harmful to self or others.
database_cross_reference: ICD10CM:F63.9
database_cross_reference: ICD9CM:312.30
database_cross_reference: MESH:D007174
database_cross_reference: NCI:C34723
database_cross_reference: SNOMEDCT_US_2023_03_01:192098008
database_cross_reference: UMLS_CUI:C0021122
has_obo_namespace: disease_ontology
id: DOID:10937
in_subset: NCIthesaurus

Axiom
annotated source: impulse control disorder
annotated property: definition
annotated target: A disease of mental health that involves a failure to resist an impulsive act or behaviour that may be harmful to self or others.
type: ECO_0007638
database_cross_reference: url:https://en.wikipedia.org/wiki/Impulse_control_disorder

cardiovascular system disease
type: Class
subclass of: disease of anatomical entity
definition: A disease of anatomical entity which occurs in the blood, heart, blood vessels or the lymphatic system that passes nutrients (such as amino acids and electrolytes), gases, hormones, blood cells or lymph to and from cells in the body to help fight diseases and help stabilize body temperature and pH to maintain homeostasis.
has_alternative_id: DOID:73
database_cross_reference: ICD9CM:429.2
database_cross_reference: MESH:D002318
database_cross_reference: NCI:C2931
database_cross_reference: SNOMEDCT_US_2023_03_01:266275004
database_cross_reference: UMLS_CUI:C0007222
has exact synonym: disease of subdivision of hemolymphoid system
has_obo_namespace: disease_ontology
id: DOID:1287
in_subset: DO AGR slim
in_subset: DO CFDE slim
in_subset: DO GXD slim
in_subset: DO MGI slim
in_subset: DO RAD slim
in_subset: NCIthesaurus

Axiom
annotated source: cardiovascular system disease
annotated property: definition
annotated target: A disease of anatomical entity which occurs in the blood, heart, blood vessels or the lymphatic system that passes nutrients (such as amino acids and electrolytes), gases, hormones, blood cells or lymph to and from cells in the body to help fight diseases and help stabilize body temperature and pH to maintain homeostasis.
type: ECO_0007638
database_cross_reference: url:http://en.wikipedia.org/wiki/Circulatory_system

conduct disorder
type: Class
subclass of: specific developmental disorder
has curation status: External
definition: A specific developmental disorder marked by a pattern of repetitive behavior wherein the rights of others or social norms are violated.
database_cross_reference: EFO:0004216
database_cross_reference: ICD10CM:F91
database_cross_reference: ICD9CM:312.9
database_cross_reference: MESH:D019955
database_cross_reference: NCI:C89329
database_cross_reference: SNOMEDCT_US_2023_03_01:430909002
database_cross_reference: UMLS_CUI:C0149654
has_obo_namespace: disease_ontology
id: DOID:12995
in_subset: NCIthesaurus

Axiom
annotated source: conduct disorder
annotated property: definition
annotated target: A specific developmental disorder marked by a pattern of repetitive behavior wherein the rights of others or social norms are violated.
type: ECO_0007638
database_cross_reference: url:http://en.wikipedia.org/wiki/Conduct_disorder
database_cross_reference: url:http://www.nmha.org/go/conduct-disorder

disease of cellular proliferation
type: Class
subclass of: disease
definition: A disease that is characterized by abnormally rapid cell division.
IEDB alternative term: neoplasm
has_alternative_id: DOID:0000818
has exact synonym: cell process disease
has exact synonym: neoplasm
has_obo_namespace: disease_ontology
id: DOID:14566
in_subset: DO FlyBase slim
in_subset: DO RAD slim

Axiom
annotated source: disease of cellular proliferation
annotated property: definition
annotated target: A disease that is characterized by abnormally rapid cell division.
type: ECO_0007638
database_cross_reference: url:http://en.wikipedia.org/w/index.php?title=Cell_proliferation

major depressive disorder
type: Class
subclass of: depressive disorder
has curation status: External
definition: A depressive disorder that is characterized by at least two weeks of loss of interest or pleasure in normally enjoyable activities or depressed mood along with additional cognitive or somatic impairments such as appetite or weight changes, sleep difficulties, psychomotor agitation or retardation, fatigue or loss of energy, diminished ability to think or concentrate, feelings of worthlessness or excessive guilt, and suicidality.
definition: The essential feature is a clinical course that is characterised by one or more Major Depressive Episodes without a history of Manic, Mixed, or Hypomanic episodes.
has_alternative_id: DOID:10614
has_alternative_id: DOID:2240
has_alternative_id: DOID:2241
has_alternative_id: DOID:7580
database_cross_reference: EFO:0003761
database_cross_reference: ICD10CM:F32
database_cross_reference: ICD10CM:F33.9
database_cross_reference: ICD9CM:296.2
database_cross_reference: ICD9CM:296.3
database_cross_reference: MIM:608520
database_cross_reference: MIM:608691
database_cross_reference: NCI:C34796
database_cross_reference: SNOMEDCT_US_2023_03_01:268621008
database_cross_reference: SNOMEDCT_US_2023_03_01:36923009
database_cross_reference: UMLS_CUI:C0024517
database_cross_reference: UMLS_CUI:C0154409
has exact synonym: clinical depression
has exact synonym: major depression
has exact synonym: recurrent major depression
has exact synonym: single major depressive episode
has exact synonym: unipolar depression
has_obo_namespace: disease_ontology
id: DOID:1470
in_subset: NCIthesaurus
comment: Xref MGI.

Axiom
annotated source: major depressive disorder
annotated property: definition
annotated target: A depressive disorder that is characterized by at least two weeks of loss of interest or pleasure in normally enjoyable activities or depressed mood along with additional cognitive or somatic impairments such as appetite or weight changes, sleep difficulties, psychomotor agitation or retardation, fatigue or loss of energy, diminished ability to think or concentrate, feelings of worthlessness or excessive guilt, and suicidality.
type: ECO_0007638
type: ECO_0007645
database_cross_reference: url:http://en.wikipedia.org/wiki/Major_depressive_disorder
database_cross_reference: url:https://pubmed.ncbi.nlm.nih.gov/30333763

disease of mental health
type: Class
subclass of: disease
definition: A disease that involves a psychological or behavioral pattern generally associated with subjective distress or disability that occurs in an individual, and which are not a part of normal development or culture.
database_cross_reference: ICD10CM:F99
database_cross_reference: MESH:D001523
database_cross_reference: NCI:C2893
database_cross_reference: SNOMEDCT_US_2023_03_01:74732009
database_cross_reference: UMLS_CUI:C0004936
has_obo_namespace: disease_ontology
id: DOID:150
in_subset: DO AGR slim
in_subset: DO CFDE slim
in_subset: DO GXD slim
in_subset: DO MGI slim
in_subset: DO RAD slim
in_subset: NCIthesaurus

Axiom
annotated source: disease of mental health
annotated property: definition
annotated target: A disease that involves a psychological or behavioral pattern generally associated with subjective distress or disability that occurs in an individual, and which are not a part of normal development or culture.
type: ECO_0007638
database_cross_reference: url:http://en.wikipedia.org/wiki/Mental_disorder

personality disorder
type: Class
subclass of: disease of mental health
has curation status: External
definition: A disease of mental health that involve long-term patterns of thoughts and behaviors that cause serious problems with relationships and work.
database_cross_reference: ICD9CM:301.8
database_cross_reference: SNOMEDCT_US_2023_03_01:191770003
database_cross_reference: UMLS_CUI:C0029707
has exact synonym: character disorder
has_obo_namespace: disease_ontology
id: DOID:1510
in_subset: DO RAD slim

Axiom
annotated source: personality disorder
annotated property: definition
annotated target: A disease of mental health that involve long-term patterns of thoughts and behaviors that cause serious problems with relationships and work.
type: ECO_0007644
database_cross_reference: url:http://www.nlm.nih.gov/medlineplus/personalitydisorders.html

cognitive disorder
type: Class
subclass of: disease of mental health
definition: A disease of mental health that affects cognitive functions including memory processing, perception and problem solving.
database_cross_reference: ICD10CM:F09
database_cross_reference: MESH:D019965
database_cross_reference: NCI:C34870
database_cross_reference: SNOMEDCT_US_2023_03_01:111479008
database_cross_reference: UMLS_CUI:C0029227
has exact synonym: cognitive disease
has_obo_namespace: disease_ontology
has_related_synonym: Organic Mental disorder
id: DOID:1561
in_subset: DO RAD slim
in_subset: NCIthesaurus

Axiom
annotated source: cognitive disorder
annotated property: definition
annotated target: A disease of mental health that affects cognitive functions including memory processing, perception and problem solving.
type: ECO_0007638
database_cross_reference: url:http://en.wikipedia.org/wiki/Cognitive_disorder

depressive disorder
type: Class
subclass of: mood disorder
definition: A mood disorder characterized by persistent sadness, emptiness, or irritability and decreased ability to function.
has_alternative_id: DOID:14672
database_cross_reference: ICD10CM:F33.9
database_cross_reference: MESH:D003863
database_cross_reference: NCI:C2982
database_cross_reference: SNOMEDCT_US_2023_03_01:41006004
database_cross_reference: UMLS_CUI:C0011570
has exact synonym: mental depression
has_obo_namespace: disease_ontology
has_related_synonym: depression
id: DOID:1596
in_subset: NCIthesaurus

Axiom
annotated source: depressive disorder
annotated property: definition
annotated target: A mood disorder characterized by persistent sadness, emptiness, or irritability and decreased ability to function.
database_cross_reference: url:https://my.clevelandclinic.org/health/diseases/9290-depression
database_cross_reference: url:https://pubmed.ncbi.nlm.nih.gov/31550874/

cancer
type: Class
subclass of: disease of cellular proliferation
has curation status: External
definition: A disease of cellular proliferation that is malignant and primary, characterized by uncontrolled cellular proliferation, local cell invasion and metastasis.
definition source: DOID:162
database_cross_reference: ICD10CM:C80.1
database_cross_reference: ICD9CM:199
database_cross_reference: ICDO:8000/3
database_cross_reference: MESH:D009369
database_cross_reference: NCI:C9305
database_cross_reference: SNOMEDCT_US_2023_03_01:269513004
database_cross_reference: UMLS_CUI:C0006826
has exact synonym: malignant neoplasm
has exact synonym: malignant tumor
has exact synonym: primary cancer
has_obo_namespace: disease_ontology
id: DOID:162
in_subset: DO AGR slim
in_subset: DO CFDE slim
in_subset: DO FlyBase slim
in_subset: DO GXD slim
in_subset: DO RAD slim
in_subset: DO cancer slim
in_subset: NCIthesaurus
comment: Updating out dated UMLS CUI.

Axiom
annotated source: cancer
annotated property: definition
annotated target: A disease of cellular proliferation that is malignant and primary, characterized by uncontrolled cellular proliferation, local cell invasion and metastasis.
type: ECO_0007638
type: ECO_0007643
database_cross_reference: url:http://en.wikipedia.org/wiki/cancer
database_cross_reference: url:https://www.merriam-webster.com/dictionary/cancer#medicalDictionary

vascular disease
type: Class
subclass of: cardiovascular system disease
definition: A cardiovascular system disease that primarily affects the blood vessels which includes the arteries, veins and capillaries that carry blood to and from the heart.
has_alternative_id: DOID:0000405
has_alternative_id: DOID:2403
has_alternative_id: DOID:2869
has_alternative_id: DOID:324
has_alternative_id: DOID:325
has_alternative_id: DOID:45
database_cross_reference: ICD10CM:I72.9
database_cross_reference: ICD9CM:442.9
database_cross_reference: MESH:D000783
database_cross_reference: MESH:D014652
database_cross_reference: MESH:D020758
database_cross_reference: MESH:D020760
database_cross_reference: NCI:C26693
database_cross_reference: NCI:C35117
database_cross_reference: SNOMEDCT_US_2023_03_01:27550009
database_cross_reference: SNOMEDCT_US_2023_03_01:371029002
database_cross_reference: SNOMEDCT_US_2023_03_01:432119003
database_cross_reference: UMLS_CUI:C0002940
database_cross_reference: UMLS_CUI:C0042373
database_cross_reference: UMLS_CUI:C0752127
database_cross_reference: UMLS_CUI:C0752130
has exact synonym: vascular tissue disease
has_obo_namespace: disease_ontology
id: DOID:178
in_subset: DO RAD slim
in_subset: NCIthesaurus

Axiom
annotated source: vascular disease
annotated property: definition
annotated target: A cardiovascular system disease that primarily affects the blood vessels which includes the arteries, veins and capillaries that carry blood to and from the heart.
type: ECO_0007638
database_cross_reference: url:http://en.wikipedia.org/wiki/Vascular_disease

anxiety disorder
type: Class
subclass of: cognitive disorder
has curation status: External
definition: A cognitive disorder that involves an excessive, irrational dread of everyday situations.
definition: A cognitive disorder that involves an excessive, irrational dread of everyday situations. [ url:http://www.nimh.nih.gov/health/topics/anxiety-disorders/index.shtml ]
has_alternative_id: DOID:12884
database_cross_reference: ICD10CM:F41.9
database_cross_reference: MESH:D001008
database_cross_reference: MIM:607834
database_cross_reference: NCI:C2878
database_cross_reference: SNOMEDCT_US_2023_03_01:65673007
database_cross_reference: UMLS_CUI:C0003469
has exact synonym: anxiety
has exact synonym: anxiety state
has_obo_namespace: disease_ontology
id: DOID:2030
in_subset: DO RAD slim
in_subset: NCIthesaurus

Axiom
annotated source: anxiety disorder
annotated property: definition
annotated target: A cognitive disorder that involves an excessive, irrational dread of everyday situations.
type: ECO_0007637
database_cross_reference: url:http://www.nimh.nih.gov/health/topics/anxiety-disorders/index.shtml

psychotic disorder
type: Class
subclass of: cognitive disorder
has curation status: External
definition: A cognitive disorder that involves abnormal thinking and perceptions resulting in a disconnection with reality.
database_cross_reference: EFO:0000677
database_cross_reference: ICD9CM:298.8
database_cross_reference: UMLS_CUI:C0029516
has exact synonym: mental or behavioural disorder
has_obo_namespace: disease_ontology
id: DOID:2468
in_subset: DO RAD slim

Axiom
annotated source: psychotic disorder
annotated property: definition
annotated target: A cognitive disorder that involves abnormal thinking and perceptions resulting in a disconnection with reality.
type: ECO_0007644
database_cross_reference: url:http://www.nlm.nih.gov/medlineplus/psychoticdisorders.html

bipolar disorder
type: Class
subclass of: mood disorder
has curation status: External
definition: A mood disorder that involves alternating periods of mania and depression.
definition: A mood disorder that involves alternating periods of mania and depression. [ url:http://en.wikipedia.org/wiki/Mood_disorder ]
has_alternative_id: DOID:3311
has_alternative_id: DOID:9554
has_alternative_id: DOID:9555
database_cross_reference: GARD:10249
database_cross_reference: ICD10CM:F31
database_cross_reference: ICD9CM:296.40
database_cross_reference: ICD9CM:296.60
database_cross_reference: ICD9CM:296.80
database_cross_reference: MESH:D001714
database_cross_reference: NCI:C34423
database_cross_reference: NCI:C34424
database_cross_reference: NCI:C34805
database_cross_reference: SNOMEDCT_US_2023_03_01:16506000
database_cross_reference: SNOMEDCT_US_2023_03_01:191627008
database_cross_reference: SNOMEDCT_US_2023_03_01:192355004
database_cross_reference: SNOMEDCT_US_2023_03_01:68569003
database_cross_reference: UMLS_CUI:C0005586
database_cross_reference: UMLS_CUI:C0005587
database_cross_reference: UMLS_CUI:C0024713
database_cross_reference: UMLS_CUI:C0236780
has exact synonym: Manic Bipolar Affective disorder
has exact synonym: Manic Depressive disorder
has exact synonym: Manic bipolar I disorder
has exact synonym: bipolar depression
has exact synonym: bipolar disorder manic phase
has exact synonym: manic depression
has exact synonym: manic disorder
has exact synonym: mixed bipolar disorder
has_obo_namespace: disease_ontology
has_related_synonym: Depressive-manic psych.
id: DOID:3312
in_subset: DO rare slim
in_subset: NCIthesaurus

Axiom
annotated source: bipolar disorder
annotated property: definition
annotated target: A mood disorder that involves alternating periods of mania and depression.
type: ECO_0007638
database_cross_reference: url:http://en.wikipedia.org/wiki/Mood_disorder

mood disorder
type: Class
subclass of: cognitive disorder
definition: A cognitive disorder that involves a disturbance in mood as the predominant underlying feature.
database_cross_reference: EFO:0004247
database_cross_reference: ICD10CM:F39
database_cross_reference: MESH:D019964
database_cross_reference: NCI:C92200
database_cross_reference: SNOMEDCT_US_2023_03_01:46206005
database_cross_reference: UMLS_CUI:C0525045
has exact synonym: episodic mood disorder
has_obo_namespace: disease_ontology
id: DOID:3324
in_subset: NCIthesaurus
comment: Updating outdated UMLS CUI.

Axiom
annotated source: mood disorder
annotated property: definition
annotated target: A cognitive disorder that involves a disturbance in mood as the predominant underlying feature.
type: ECO_0007638
database_cross_reference: url:https://en.wikipedia.org/wiki/Mood_disorder

tuberculosis
type: Class
subclass of: primary bacterial infectious disease
has curation status: External
definition: A primary bacterial infectious disease that is located_in lungs, located_in lymph nodes, located_in pericardium, located_in brain, located_in pleura or located_in gastrointestinal tract, has_material_basis_in Mycobacterium tuberculosis, which is transmitted_by droplets released into the air when an infected person coughs or sneezes.
alternative term: TB
definition source: DOID:399
has_alternative_id: DOID:10096
has_alternative_id: DOID:12688
has_alternative_id: DOID:12691
has_alternative_id: DOID:415
has_alternative_id: DOID:9901
has_alternative_id: DOID:9902
database_cross_reference: GARD:7827
database_cross_reference: MESH:D014375
database_cross_reference: SNOMEDCT_US_2023_03_01:15202009
database_cross_reference: UMLS_CUI:C0041295
has_obo_namespace: disease_ontology
id: DOID:399
in_subset: DO infectious disease slim
in_subset: DO rare slim
in_subset: gram-positive bacterial infectious disease

Axiom
annotated source: tuberculosis
annotated property: definition
annotated target: A primary bacterial infectious disease that is located_in lungs, located_in lymph nodes, located_in pericardium, located_in brain, located_in pleura or located_in gastrointestinal tract, has_material_basis_in Mycobacterium tuberculosis, which is transmitted_by droplets released into the air when an infected person coughs or sneezes.
type: ECO_0007637
database_cross_reference: url:https://www.merckmanuals.com/home/infections/tuberculosis-and-related-infections/tuberculosis-tb

disease
type: Class
subclass of: disposition
definition: A disease is a disposition (i) to undergo pathological processes that (ii) exists in an organism because of one or more disorders in that organism.
database_cross_reference: MESH:D004194
database_cross_reference: NCI:C2991
database_cross_reference: SNOMEDCT_US_2023_03_01:64572001
database_cross_reference: UMLS_CUI:C0012634
has_obo_namespace: disease_ontology
id: DOID:4
in_subset: DO RAD slim
in_subset: NCIthesaurus

Axiom
annotated source: disease
annotated property: definition
annotated target: A disease is a disposition (i) to undergo pathological processes that (ii) exists in an organism because of one or more disorders in that organism.
type: ECO_0007645
database_cross_reference: url:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3041577/

human immunodeficiency virus infectious disease
type: Class
subclass of: viral infectious disease
has curation status: External
definition: A viral infectious disease that results in destruction of immune system, leading to life-threatening opportunistic infections and cancers, has_material_basis_in Human immunodeficiency virus 1 (Lentivirus humimdef1) or Human immunodeficiency virus 2 (Lentivirus humimdef2), which are transmitted by sexual contact, transmitted by transfer of blood, semen, vaginal fluid, pre-ejaculate, or breast milk, transmitted by congenital method, and transmitted by contaminated needles. The virus infects helper T cells (CD4+ T cells) which are directly or indirectly destroyed, macrophages, and dendritic cells. The infection has symptom diarrhea, has symptom fatigue, has symptom fever, has symptom vaginal yeast infection, has symptom headache, has symptom mouth sores, has symptom muscle aches, has symptom sore throat, and has symptom swollen lymph glands.
definition: A viral infectious disease that results in destruction of immune system, leading to life-threatening opportunistic infections and cancers, has_material_basis_in Human immunodeficiency virus 1 or has_material_basis_in Human immunodeficiency virus 2, which are transmitted by sexual contact, transmitted by transfer of blood, semen, vaginal fluid, pre-ejaculate, or breast milk, transmitted by congenital method, and transmitted by contaminated needles. The virus infects helper T cells (CD4 T cells) which are directly or indirectly destroyed, macrophages, and dendritic cells. The infection has symptom diarrhea, has symptom fatigue, has symptom fever, has symptom vaginal yeast infection, has symptom headache, has symptom mouth sores, has symptom muscle aches, has symptom sore throat, and has symptom swollen lymph glands.
database_cross_reference: ICD10CM:B20
database_cross_reference: ICD9CM:042
database_cross_reference: ICD9CM:042-042.99
database_cross_reference: MESH:D015658
database_cross_reference: NCI:C3108
database_cross_reference: SNOMEDCT_US_2023_03_01:86406008
database_cross_reference: UMLS_CUI:C0019693
has exact synonym: HIV infection
has_obo_namespace: disease_ontology
id: DOID:526
in_subset: DO infectious disease slim
in_subset: NCIthesaurus
in_subset: zoonotic infectious disease

Axiom
annotated source: human immunodeficiency virus infectious disease
annotated property: definition
annotated target: A viral infectious disease that results in destruction of immune system, leading to life-threatening opportunistic infections and cancers, has_material_basis_in Human immunodeficiency virus 1 (Lentivirus humimdef1) or Human immunodeficiency virus 2 (Lentivirus humimdef2), which are transmitted by sexual contact, transmitted by transfer of blood, semen, vaginal fluid, pre-ejaculate, or breast milk, transmitted by congenital method, and transmitted by contaminated needles. The virus infects helper T cells (CD4+ T cells) which are directly or indirectly destroyed, macrophages, and dendritic cells. The infection has symptom diarrhea, has symptom fatigue, has symptom fever, has symptom vaginal yeast infection, has symptom headache, has symptom mouth sores, has symptom muscle aches, has symptom sore throat, and has symptom swollen lymph glands.
type: ECO_0007638
database_cross_reference: url:http://en.wikipedia.org/wiki/HIV
database_cross_reference: url:https://medlineplus.gov/hiv.html
database_cross_reference: url:https://www.cdc.gov/hiv/about/index.html

disease of anatomical entity
type: Class
subclass of: disease
definition: A disease that manifests in a defined anatomical structure.
has_alternative_id: DOID:1
has_alternative_id: DOID:2
has_alternative_id: DOID:5
has_alternative_id: DOID:71
has_alternative_id: DOID:72
has_alternative_id: DOID:8
has_obo_namespace: disease_ontology
id: DOID:7
in_subset: DO RAD slim

Axiom
annotated source: disease of anatomical entity
annotated property: definition
annotated target: A disease that manifests in a defined anatomical structure.
type: ECO_0007643
database_cross_reference: url:https://www.merriam-webster.com/medical/anatomic

viral infectious disease
type: Class
subclass of: disease by infectious agent
definition: A disease by infectious agent that results in infection, has_material_basis_in Viruses.
has_alternative_id: DOID:1329
database_cross_reference: ICD10CM:A94
database_cross_reference: ICD10CM:B34.9
database_cross_reference: ICD9CM:060-066.99
database_cross_reference: MESH:D001102
database_cross_reference: MESH:D014777
database_cross_reference: NCI:C3439
database_cross_reference: NCI:C34396
database_cross_reference: SNOMEDCT_US_2023_03_01:34014006
database_cross_reference: SNOMEDCT_US_2023_03_01:40610006
database_cross_reference: UMLS_CUI:C0003723
database_cross_reference: UMLS_CUI:C0042769
has exact synonym: Viral Infection
has exact synonym: Viral disease
has exact synonym: virus infection
has_obo_namespace: disease_ontology
id: DOID:934
in_subset: DO AGR slim
in_subset: DO FlyBase slim
in_subset: DO infectious disease slim
in_subset: NCIthesaurus

Axiom
annotated source: viral infectious disease
annotated property: definition
annotated target: A disease by infectious agent that results in infection, has_material_basis_in Viruses.
type: ECO_0007637
database_cross_reference: url:http://www.merck.com/mmhe/sec17/ch198/ch198a.html

human construction
type: Class
subclass of: astronomical body part
subclass of: construction
has curation status: External
definition: A construction that has been assembled by deliberate human effort.
editor note: "constructed" should probably be made something like a quality and this class obsoleted or filled only by inference
has exact synonym: constructed feature

Axiom
annotated source: human construction
annotated property: definition
annotated target: A construction that has been assembled by deliberate human effort.
database_cross_reference: MA:ma

environmental material
type: Class
subclass of: material entity
has curation status: External
definition: A material entity which other material entities in an environmental system are primarily or partially composed of.
definition: A portion of environmental material is a fiat object part which forms the medium or part of the medium of an environmental system.
has exact synonym: portion of environmental material
comment: Everything under this parent must be a mass noun (i.e. not countable). All subclasses are to be understood as being composed primarily of the named entity, rather than restricted to that entity. For example, "ENVO:water" is to be understood as "environmental material composed primarly of some CHEBI:water".
comment: Instances of this class are portions of environmental materials, such as seawater in bucket, a water parcel in the photic zone of a lake, or the concrete that composes a building part. Instances of these portions may have fiat or non-fiat boundaries. For example, a water parcel has not physical boundaries, while the seawater in a bucket is bounded by the internal surfaces of the bucket.

Axiom
annotated source: environmental material
annotated property: definition
annotated target: A material entity which other material entities in an environmental system are primarily or partially composed of.
database_cross_reference: niches.html
database_cross_reference: https://dx.doi.org/10.1186/2041-1480-4-43
database_cross_reference: Material

aerosol
type: Class
subclass of: environmental material
has curation status: External
definition: Airborne solid particles (also called dust or particulate matter (PM)) or liquid droplets.
database_cross_reference: EcoLexicon:aerosol
database_cross_reference: SWEETRealm:Aerosol
in_subset: envoAtmo
comment: Should connect to PATO as "quality of an aerosol"

Axiom
annotated source: aerosol
annotated property: definition
annotated target: Airborne solid particles (also called dust or particulate matter (PM)) or liquid droplets.
database_cross_reference: https://en.wikipedia.org/wiki/Aerosol

environmental system
type: Class
subclass of: system
subclass of: Restriction
  on property: has disposition
  some values from: environmental disposition
has curation status: External
definition: A system which has the disposition to environ one or more material entities.
alternative term: environment
creation date: 2013-09-23T16:04:08Z
database_cross_reference: EcoLexicon:environment
has exact synonym: environment
comment: In ENVO's alignment with the Basic Formal Ontology, this class is being considered as a subclass of a proposed BFO class "system". The relation "environed_by" is also under development. Roughly, a system which includes a material entity (at least partially) within its site and causally influences that entity may be considered to environ it. Following the completion of this alignment, this class' definition and the definitions of its subclasses will be revised.

Axiom
annotated source: environmental system
annotated property: definition
annotated target: A system which has the disposition to environ one or more material entities.
database_cross_reference: DOI:10.1186/2041-1480-4-43

environmental disposition
type: Class
subclass of: disposition
has curation status: External
definition: A disposition which is realised by an environmental system or system parts thereof.
created by: ORCID:0000-0002-4366-3088
comment: This class and its subclasses are experimental and are being developed with NCEAS use cases in mind.

fire
type: Class
subclass of: combustion process
has curation status: External
definition: A fire is a process whereby rapid and exothermic oxidation of a material through a combustion process releases heat, light, and other products.
definition source: ENVO:01000786
comment: Not to be confused with a flame - the visible portion of gas released by a fire . Oxidation processes such as rusting or biological digestion are not subsumed here.

Axiom
annotated source: fire
annotated property: definition
annotated target: A fire is a process whereby rapid and exothermic oxidation of a material through a combustion process releases heat, light, and other products.
database_cross_reference: http://www.eionet.europa.eu/gemet/en/concept/3212
database_cross_reference: https://en.wikipedia.org/wiki/Fire

astronomical body part
type: Class
subclass of: material entity
definition: A material part of an astronomical body.
editor note: Also note that some astronomical body parts (ABPs) may have fiat boundaries: if there's strong debate about where an ABP begins or ends (over and above fuzzy boundaries), with different official classifications setting different thresholds or limits, axiomatise the class with fiat boundaries of the appropriate dimension.
editor note: Note that material entities may have immaterial entities (e.g. sites) as parts.
editor note: This class includes material parts of astronomical bodies. Immaterial parts, such as magnetospheres, are represented as sites under the influence of magnetic fields.Please post countercases in the ENVO tracker for revision of this hierarchy if needed.
in_subset: envoAstro
in_subset: envoPolar
comment: Material parts of astronomical bodies generally have boundaries formed by discontinuities in qualities, composition, or other physical characterisitcs. These boundaries are sometimes sharp, and sometimes diffuse, with different classification systems and communities declaring varying thresholds (e.g. for where a shoreline, forest, or other entity begins and ends). However, some boundaries are declared by fiat - that is, by arbitrary human convention or decree - particularly by regulatory or other authorities and communities of practice. The classes in this hierarchy attempt to offer generalisable definitions that allow multiple classfiication systems to map to and interoperate through. If desired, we can create classes that declare thresholds used by a given authority or community under the more generic ones, annotated with source information.

smoke
type: Class
subclass of: aerosol
has curation status: External
definition: Smoke is a collection of airborne solid and liquid particulates and gases emitted when a material undergoes combustion or pyrolysis, together with the quantity of gas that is entrained or otherwise mixed into the mass
definition source: ENVO:01000838
comment: Smoke is a collection of airborne solid and liquid particulates and gases emitted when a material undergoes combustion or pyrolysis, together with the quantity of gas that is entrained or otherwise mixed into the mass

Axiom
annotated source: smoke
annotated property: comment
annotated target: Smoke is a collection of airborne solid and liquid particulates and gases emitted when a material undergoes combustion or pyrolysis, together with the quantity of gas that is entrained or otherwise mixed into the mass
database_cross_reference: https://en.wikipedia.org/wiki/Smoke

combustion process
type: Class
subclass of: thermolysis
subclass of: aerosol formation process
definition: Combustion or burning is a high-temperature exothermic redox chemical reaction between a fuel and an oxidant that produces oxidized, often gaseous products, in a mixture termed as smoke.
editor note: This class may be surrendered to REX.
comment: Unlike the "combustion" class in the Chemical Methods Ontology, this class is not necessarily a planned process. http://purl.obolibrary.org/obo/CHMO_0001473

Axiom
annotated source: combustion process
annotated property: definition
annotated target: Combustion or burning is a high-temperature exothermic redox chemical reaction between a fuel and an oxidant that produces oxidized, often gaseous products, in a mixture termed as smoke.
database_cross_reference: https://en.wikipedia.org/wiki/Combustion

thermolysis
type: Class
subclass of: material transformation process
definition: A chemical decomposition (the separation of a single chemical compound into its two or more elemental parts or to simpler compounds) caused by heat.
has exact synonym: thermal decomposition

aerosol formation process
type: Class
subclass of: material transformation process
definition: A material transformation process during which solid or liquid particles form and are suspended in a mass of air, thus creating an aerosol.
creator: https://orcid.org/0000-0002-4366-3088
date: 2019-06-24T13:43:29Z

construction
type: Class
subclass of: material entity
subclass of: Restriction
  on property: part of
  some values from: environmental system
has curation status: External
definition: A material entity which has been assembled through the intentional, instinctual, or deliberately programmed efforts of an organism or machine.
creator: https://orcid.org/0000-0002-4366-3088
date: 2019-10-29T14:50:34Z

environmental system process
type: Class
subclass of: process
definition: A process in which includes the components of an environmental system as participants.
comment: This is a convenience class for organisation and should not be used for annotation.

material transformation process
type: Class
subclass of: environmental system process
definition: A process during which a portion of some environmental material is converted into a different material or a collection of materials.
editor note: A different material transformation process class (or similarly named class) pertaining to the conversion of a specific chemical into another belongs in CHEBI and or REX ontologies.
definition editor: https://orcid.org/0000-0002-4366-3088
definition editor: http://orcid.org/0000-0002-3410-4655
in_subset: envoPolar
comment: Experimental class for structural purposes not recommended for annotation. A material transformation process only refers to ENVO:environmental material classes (e.g. bulk and typically impure substances), rather than transformations converting a specific chemical into another.

agent delivery
type: Class
subclass of: process
example of usage: An injection.
has curation status: IAO_0000120
definition: A material processing technique performed to locally deliver an agent to a recipient.
definition editor: PERSON: Nicole Vasilevsky
definition source: PERSON: Nicole Vasilevsky

intubation
type: Class
subclass of: agent delivery
example of usage: Intubation of a patient whose airway is blocked.
has curation status: IAO_0000120
has curation status: External
definition: Agent delivery of a tube into an external or internal orifice of the body for the purpose of adding or removing fluids or air.
definition editor: PERSON: Nicole Vasilevsky
alternative term: Entubation
definition source: http://en.wikipedia.org/wiki/Intubation

geographic location
type: Class
subclass of: spatial region
has curation status: External
definition: A reference to a place on the Earth, by its name or by its geographical location
definition: A reference to a place on the Earth, by its name or by its geographical location.
definition source: Gazeteer Ontology
has_alternative_id: GAZ:00000467
has exact synonym: geographic region {alternative name}
has_obo_namespace: GAZ
id: GAZ:00000448

conditional specification
type: Class
subclass of: directive information entity
editor preferred label: conditional specification
has curation status: IAO_0000120
definition: A directive information entity that specifies what should happen if the trigger condition is fulfilled.
definition editor: PlanAndPlannedProcess Branch
definition source: OBI branch derived
definition source: OBI_0000349

action specification
type: Class
subclass of: directive information entity
example of usage: Pour the contents of flask 1 into flask 2
has curation status: IAO_0000122
has curation status: External
definition: A directive information entity that describes an action the bearer will take.
definition editor: Alan Ruttenberg
definition source: OBI Plan and Planned Process branch

data item
type: Class
subclass of: information content entity
editor preferred label: data item
example of usage: Data items include counts of things, analyte concentrations, and statistical summaries.
has curation status: IAO_0000125
definition: An information content entity that is intended to be a truthful statement about something (modulo, e.g., measurement precision or other systematic errors) and is constructed/acquired by a method which reliably tends to produce (approximately) truthful statements.
editor note: 2/2/2009 Alan and Bjoern discussing FACS run output data. This is a data item because it is about the cell population. Each element records an event and is typically further composed a set of measurment data items that record the fluorescent intensity stimulated by one of the lasers.
editor note: 2009-03-16: data item deliberatly ambiguous: we merged data set and datum to be one entity, not knowing how to define singular versus plural. So data item is more general than datum.
editor note: 2009-03-16: removed datum as alternative term as datum specifically refers to singular form, and is thus not an exact synonym.
editor note: 2014-03-31: See discussion at http://odontomachus.wordpress.com/2014/03/30/aboutness-objects-propositions/
editor note: JAR: datum -- well, this will be very tricky to define, but maybe some information-like stuff that might be put into a computer and that is meant, by someone, to denote and/or to be interpreted by some process... I would include lists, tables, sentences... I think I might defer to Barry, or to Brian Cantwell Smith JAR: A data item is an approximately justified approximately true approximate belief
definition editor: PERSON: Alan Ruttenberg
definition editor: PERSON: Chris Stoeckert
definition editor: PERSON: Jonathan Rees
alternative term: data
imported from: iao.owl
imported from: ogms.owl

information content entity
type: Class
subclass of: generically dependent continuant
editor preferred label: information content entity
example of usage: Examples of information content entites include journal articles, data, graphical layouts, and graphs.
has curation status: IAO_0000122
has curation status: External
definition: A generically dependent continuant that is about some thing.
editor note: 2014-03-10: The use of "thing" is intended to be general enough to include universals and configurations (see https://groups.google.com/d/msg/information-ontology/GBxvYZCk1oc/-L6B5fSBBTQJ).
editor note: information_content_entity 'is_encoded_in' some digital_entity in obi before split (040907). information_content_entity 'is_encoded_in' some physical_document in obi before split (040907). Previous. An information content entity is a non-realizable information entity that 'is encoded in' some digital or physical entity.
definition editor: PERSON: Chris Stoeckert
definition source: OBI_0000142
imported from: iao.owl
imported from: ogms.owl

directive information entity
type: Class
subclass of: information content entity
editor preferred label: directive information entity
has curation status: IAO_0000122
has curation status: External
definition: An information content entity whose concretizations indicate to their bearer how to realize them in a process.
editor note: 2009-03-16: provenance: a term realizable information entity was proposed for OBI (OBI_0000337) , edited by the PlanAndPlannedProcess branch. Original definition was "is the specification of a process that can be concretized and realized by an actor" with alternative term "instruction".It has been subsequently moved to IAO where the objective for which the original term was defined was satisfied with the definitionof this, different, term.
editor note: 2013-05-30 Alan Ruttenberg: What differentiates a directive information entity from an information concretization is that it can have concretizations that are either qualities or realizable entities. The concretizations that are realizable entities are created when an individual chooses to take up the direction, i.e. has the intention to (try to) realize it.
editor note: 8/6/2009 Alan Ruttenberg: Changed label from "information entity about a realizable" after discussions at ICBO
editor note: Werner pushed back on calling it realizable information entity as it isn't realizable. However this name isn't right either. An example would be a recipe. The realizable entity would be a plan, but the information entity isn't about the plan, it, once concretized, *is* the plan. -Alan
definition editor: PERSON: Alan Ruttenberg
definition editor: PERSON: Bjoern Peters
imported from: iao.owl

rule
type: Class
subclass of: conditional specification
editor preferred label: rule
example of usage: example to be added
has curation status: IAO_0000123
has curation status: External
definition: A conditional specification that guides, defines, restricts actions.
definition: A rule is an executable which guides, defines, restricts actions.
editor note: MSI
definition editor: PRS
definition source: OBI_0500021
definition source: PRS
curator note: The definition has been tweaked to make it consistent with the recommended format.

report
type: Class
subclass of: document
editor preferred label: report
example of usage: Examples of reports are gene lists and investigation reports. These are not published (journal) articles but may be included in a journal article.
has curation status: IAO_0000125
has curation status: External
definition: A document assembled by an author for the purpose of providing information for the audience. A report is the output of a documenting process and has the objective to be consumed by a specific audience. Topic of the report is on something that has completed. A report is not a single figure. Examples of reports are journal article, patent application, grant progress report, case report (not patient record).
editor note: 2009-03-16: comment from Darren Natale: I am slightly uneasy with the sentence "Topic of the report is on something that has completed." Should it be restricted to those things that are completed? For example, a progress report is (usually) about something that definitely has *not* been completed, or may include (only) projections. I think the definition would not suffer if the whole sentence is deleted.
editor note: 2009-03-16: this was report of results with definition: A report is a narrative object that is a formal statement of the results of an investigation, or of any matter on which definite information is required, made by some person or body instructed or required to do so.
editor note: 2009-03-16: work has been done on this term during during the OBI workshop winter 2009 and the current definition was considered acceptable for use in OBI. If there is a need to modify this definition please notify OBI.
editor note: 2009-08-10 Alan Ruttenberg: Larry Hunter suggests that this be obsoleted and replaced by 'document'. Alan restored as there are OBI dependencies and this merits further discussion
editor note: disagreement about where reports go. alan: only some gene lists are reports. Is a report all the content of some document? The example of usage suggests that a report may be part of some article. Term needs clarification
definition editor: PERSON: Alan Ruttenberg
definition editor: PERSON: Chris Stoeckert
definition editor: PERSON: Melanie Courtot
definition source: GROUP: OBI
definition source: OBI_0000099

plan specification
type: Class
subclass of: directive information entity
editor preferred label: plan specification
example of usage: PMID: 18323827.Nat Med. 2008 Mar;14(3):226.New plan proposed to help resolve conflicting medical advice.
has curation status: IAO_0000122
has curation status: External
definition: A directive information entity with action specifications and objective specifications as parts that, when concretized, is realized in a process in which the bearer tries to achieve the objectives by taking the actions specified.
definition: A directive information entity with action specifications and objective specifications as parts, and that may be concretized as a realizable entity that, if realized, is realized in a process in which the bearer tries to achieve the objectives by taking the actions specified.
editor note: 2009-03-16: provenance: a term a plan was proposed for OBI (OBI_0000344) , edited by the PlanAndPlannedProcess branch. Original definition was " a plan is a specification of a process that is realized by an actor to achieve the objective specified as part of the plan". It has been subsequently moved to IAO where the objective for which the original term was defined was satisfied with the definitionof this, different, term.
editor note: 2014-03-31: A plan specification can have other parts, such as conditional specifications.
editor note: 2022-01-16 Updated definition to that proposed by Clint Dowloand, IAO Issue 231.
editor note: Alternative previous definition: a plan is a set of instructions that specify how an objective should be achieved
definition editor: Alan Ruttenberg
definition editor: Clint Dowland
definition source: OBI Plan and Planned Process branch
definition source: OBI_0000344
imported from: iao.owl
comment: 2/3/2009 Comment from OBI review. Action specification not well enough specified. Conditional specification not well enough specified. Question whether all plan specifications have objective specifications. Request that IAO either clarify these or change definitions not to use them

measurement datum
type: Class
subclass of: data item
editor preferred label: measurement datum
definition: A measurement datum is an information content entity that is a recording of the output of a measurement such as produced by a device.
imported from: iao.owl

material information bearer
type: Class
subclass of: material entity
editor preferred label: material information bearer
example of usage: A page of a paperback novel with writing on it. The paper itself is a material information bearer, the pattern of ink is the information carrier.
example of usage: a brain
example of usage: a hard drive
has curation status: IAO_0000122
definition: A material entity in which a concretization of an information content entity inheres.
definition editor: GROUP: IAO

document
type: Class
subclass of: information content entity
editor preferred label: document
example of usage: A journal article, patent application, laboratory notebook, or a book
has curation status: IAO_0000120
has curation status: External
definition: A collection of information content entities intended to be understood together as a whole
definition: A collection of information content entities intended to be understood together as a whole.
definition editor: PERSON: Lawrence Hunter

emotion process
type: Class
subclass of: affective process
example of usage: "Activity-related" in the Health Promotion Model
example of usage: "Affective reactions" in the Affective Events Theory
example of usage: "Context-related" in the Health Promotion Model
example of usage: "Feedback intervention-induced affect" in the Feedback Intervention Theory
example of usage: "Self-related" in the Health Promotion Model
example of usage: "Affective processes" in the Feedback Intervention Theory
has curation status: External
definition: An <affective process> that is a synchronized aggregate of constituent mental processes, including an appraisal process, which is valenced, has an object, and gives rise to an action tendency.
definition: An affective process that is a synchronized aggregate of constituent mental processes including an appraisal process, which is valenced, has an object, and gives rise to an action tendency.
synonym: occurrent emotion
synonym: short-term emotion
comment: Emotion processes are distinguished from other affective processes (e.g., mood) by having an object. Even if an emotion is experienced due to physiological reasons, they would be felt as being about something or someone. For instance, a person might be angry at a situation that they would normally not be angry at, because they are hungry. However, that person would still be angry at a specific situation.
comment: There is no intended sequence of the entities that are part of the emotion process (e.g., an appraisal process does not necessarily precede a physiological process part of the emotion process). Emotion processes are distinguished from other affective processes (e.g., mood) by having an object. Even if an emotion is experienced due to physiological reasons, they would be felt as being about something or someone. For instance, a person might be angry at a situation that they would normally not be angry at, because they are hungry. However, that person would still be angry at a specific situation. Valence refers to the 'the subjective value of an event, object, person, or other entity in the life space of the individual' (https://dictionary.apa.org/valence). Valence ranges from negative to positive.
comment: There is no rigid sequence of the entities that are part of the emotion process (e.g., an appraisal process does not necessarily precede a physiological process part of the emotion process).
comment: Valence refers to the 'the subjective value of an event, object, person, or other entity in the life space of the individual' (https://dictionary.apa.org/valence). Valence ranges from negative to positive.

affective appraisal
type: Class
subclass of: cognitive representation
has curation status: External
definition: A cognitive representation of the emotional relevance of an object or event to the organism.
definition: A cognitive representation which represents an evaluation of the relevance of some triggering object or event to the organism.
comment: Appraisals are a part of emotion processes, representing how a triggering stimulus is relevant to the self. Appraisal captures the ‘aboutness’ of an emotion process. For example, a stimulus such as an image of a tiger can produce different emotion processes depending on how the relevance of this stimulus is evaluated. If the image of a tiger was on TV, this would likely not be evaluated as dangerous. However, an image of a tiger two meters away from a person would be relevant to a person in terms of its dangerousness. Therefore, an appraisal of the dangerouness of the tiger would be part of the emotion process 'fear'.
comment: There is no rigid sequence of the entities that are part of the emotion process -- an appraisal does not necessarily precede a physiological process part of the emotion process.
label: affective apraisal

subjective affective feeling
type: Class
subclass of: affective process
example of usage: "Regulatory fit" in the Regulatory Fit Theory
example of usage: "Wants" in the PRIME theory
has curation status: External
definition: An <affective process> that involves the experience of internal or external sensory stimuli.
definition: An affective process that involves the experience of internal or external sensory stimuli.
definition: The subjective emotional feeling is that (fiat) part of the emotion process by which the organism experiences its own emotion.
alternative term: pain
synonym: affective consciousness
has_alternative_id: http://purl.obolibrary.org/obo/MFOEM_000202
comment: 'Subjective affective feeling can have greater or weaker physiological or mental components. The bodily process that are experienced will usually involve some mental process. Bodily sensation and the experiences of emotions (e.g., feeling calm) would both qualify as examples of 'subjective affective feeling'. As a subclass of 'affective process', subjective affective feelings have valence. Valence refers to the 'the subjective value of an event, object, person, or other entity in the life space of the individual' (https://dictionary.apa.org/valence). Valence ranges from negative to positive.
comment: As a subclass of 'affective process', subjective affective feelings have valence. Valence refers to the 'the subjective value of an event, object, person, or other entity in the life space of the individual' (https://dictionary.apa.org/valence). Valence ranges from negative to positive.
comment: Bodily sensations and the experiences of emotions (e.g., feeling calm) would both qualify as examples of 'subjective affective feeling'.
comment: Excluded the following subjective feelings which appear on the GRID questionnaire since they seem debatable to what extent they are really *feelings* and to what extent they are actually *evaluations* or other things: -- felt submissive/dominant -- felt powerless/powerful
comment: Subjective affective feeling can have greater or weaker physiological or mental components. The bodily processes that are experienced will usually involve some mental process.
label: subjective emotional feeling

pleasure (emotion)
type: Class
subclass of: emotion process
example of usage: "Pleasantness" in the Feedback Intervention Theory
has curation status: External
definition: A positive emotion which is sought out and is associated with happiness and satisfaction.
alternative term: enjoyment
synonym: placer @es
synonym: plaisir @fr
synonym: vergnügen @de
tag display synonym: pleased

affective process
type: Class
subclass of: mental process
example of usage: "Affect" in the Health Promotion Model
example of usage: "Mood / arousal" in the Social Action Theory (Ewart)
example of usage: "Feelings" in the Risk as Feelings
has curation status: External
definition: A <mental process> that has positive or negative valence.
definition: A mental process that has positive or negative valence.
definition: An affective process is any process that has positive or negative valence.
comment: Valence refers to the 'the subjective value of an event, object, person, or other entity in the life space of the individual' (https://dictionary.apa.org/valence). Valence ranges from negative to positive.

human being
type: Class
subclass of: extended organism
has curation status: External
definition: An extended organism that is a member of the species Homo sapiens.
alternative term: person
label: person

mental process
type: Class
subclass of: bodily process
has curation status: External
definition: A <bodily process> that occurs in the brain, and that can of itself be conscious, or can give rise to a process that can of itself be conscious or can give rise to behaviour.
definition: A bodily process that occurs in the brain, and that can of itself be conscious, or can give rise to a process that can of itself be conscious or can give rise to behaviour.
definition: Valence is a process profile of an emotion, mood, or affective bodily feeling (such as pleasure and pain). Valence can be positive or negative, with different strengths in both directions. For example, pleasure is positively valenced while pain is negatively valenced.
comment: A 'mental process' is a subclass of 'bodily process', as mental processes occur within the body, specifically involving the brain.
comment: A bodily process which brings into being, sustains or modifies a cognitive representation or a behavior inducing state.
comment: Examples include thinking, feeling pain, remembering and emotion as occurrent experiences.
comment: Mental processes can vary in the degree to which they involve consciousness. A 'mental process' is a subclass of 'bodily process', as mental processes occur within the body, specifically involving the brain.
comment: Mental processes can varying in the degree to which they involve consciousness.
see also: GO:0050890, cognition, defined as `The operation of the mind by which an organism becomes aware of objects of thought or perception; it includes the mental activities associated with thinking, learning, and memory.'

representation
type: Class
subclass of: specifically dependent continuant
has curation status: External
definition: A dependent continuant which is about a portion of reality.
definition source: http://www.jbiomedsem.com/content/1/1/10

cognitive representation
type: Class
subclass of: representation
has curation status: External
definition: A representation which specifically depends on an anatomical structure in the cognitive system of an organism.
definition source: http://www.jbiomedsem.com/content/1/1/10
comment: Cognitive representations can be held by individuals or groups.
comment: When a belief is activated, the content of that belief is a cognitive representation. The use of the phrase ‘an anatomical structure in the cognitive system’ in the formal definition means that a specific cognitive representation will depend on parts of the brain, rather than involving the whole brain.

bodily disposition
type: Class
subclass of: disposition
example of usage: "Internal environment" in the PRIME theory
has curation status: External
definition: A <disposition> that inheres in some extended organism.
definition: A bodily disposition is a disposition that inheres in some extended organism. Examples are: my disposition to catch a cold when exposed to a virus, my ability to speak the English language.
definition: A disposition that inheres in some extended organism.
alternative term: personal disposition
comment: Bodily disposition includes features that can be used in a specific context, such as a person's strength, but not a person's weight. A person has a specific weight independent of the circumstances they are in.
comment: Extended organism refers to an organism and its microbiome (e.g., the bacteria that live in one's digestive system) Bodily disposition would include features, such as a person's strength (which can be used in a specific context), but not weight. A person would have a certain weight independent of most circumstances they are in.
comment: Extended organism refers to an organism and its microbiome (e.g., the bacteria that live in one's digestive system).

mental disposition
type: Class
subclass of: bodily disposition
example of usage: "Psychological" in the Health Promotion Model
example of usage: "Psychological factors" in the I-Change Model
has curation status: External
definition: A <bodily disposition> that is realized in a mental process.
definition: A bodily disposition that is realized in a mental process.
definition: A mental disposition is a bodily disposition that is realized in a mental process.
comment: 'Mental disposition' is a subclass of 'bodily disposition', as mental dispositions occur in the body.
comment: Mental disposition' is a subclass of 'bodily disposition', as mental dispositions occur in the body.

statistical model
type: Class
subclass of: directive information entity
has curation status: External
definition: A directive information entity that represents a mathematical relationship which relates changes in a given response to changes in one or more factors. A statistical model is a formalization of relationships between variables in the form of mathematical equations.
definition editor: Marcy Harris, Yongqun He
alternative term: model
definition source: WEB: http://www.itl.nist.gov/div898/handbook/pri/section7/pri7.htm; http://en.wikipedia.org/wiki/Statistical_model

credible interval
type: Class
subclass of: quantitative confidence value
has curation status: External
definition: A quantitative confidence value that is used in Bayesian analysis to describe the range in which a posterior probability estimate is likely to reside.
definition editor: Yongqun He
definition source: WEB: http://www.uptodate.com/contents/glossary-of-common-biostatistical-and-epidemiological-terms

standardized mortality ratio
type: Class
subclass of: derived data from inferential statistical analysis
has curation status: External
definition: A data item which is the ratio of observed deaths in the study group to expected deaths in the general population.
definition editor: Person: Jie Zheng, Oliver He
alternative term: SMR
definition source: http://en.wikipedia.org/wiki/Standardized_mortality_ratio

derived data from statistical analysis
type: Class
subclass of: transformed data item
definition: A data item that is derived from a statistical data analysis.
definition editor: Jie Zheng, Yongqun He, Marcy Harris, Asiyah Yu Lin
alternative term: statistic
definition source: WEB: http://en.wikipedia.org/wiki/Statistic
definition source: WEB: http://www.ask.com/question/what-is-numerical-data

derived data from inferential statistical analysis
type: Class
subclass of: derived data from statistical analysis
definition: A data item that is derived from an inferential statistical data analysis.
definition editor: Jie Zheng, Yongqun He
alternative term: inferential statistic
definition source: WEB: http://psc.dss.ucdavis.edu/sommerb/sommerdemo/stat_inf/intro.htm
definition source: WEB: http://www.ask.com/question/what-is-numerical-data

transformed data item
type: Class
subclass of: data item
definition: A data item that is produced as the output of a data transformation.
definition editor: Person: Jie Zheng, Oliver He

planned process
type: Class
subclass of: process
editor preferred label: planned process
example of usage: Injecting mice with a vaccine in order to test its efficacy
has curation status: IAO_0000122
definition: A process that realizes a plan which is the concretization of a plan specification.
editor note: 'Plan' includes a future direction sense. That can be problematic if plans are changed during their execution. There are however implicit contingencies for protocols that an agent has in his mind that can be considered part of the plan, even if the agent didn't have them in mind before. Therefore, a planned process can diverge from what the agent would have said the plan was before executing it, by adjusting to problems encountered during execution (e.g. choosing another reagent with equivalent properties, if the originally planned one has run out.)
editor note: We are only considering successfully completed planned processes. A plan may be modified, and details added during execution. For a given planned process, the associated realized plan specification is the one encompassing all changes made during execution. This means that all processes in which an agent acts towards achieving some objectives is a planned process.
definition editor: Bjoern Peters
definition source: branch derived
curator note: 6/11/9: Edited at workshop. Used to include: is initiated by an agent
curator note: This class merges the previously separated objective driven process and planned process, as they the separation proved hard to maintain. (1/22/09, branch call)
imported from: obi.owl

drug role
type: Class
subclass of: role
editor preferred label: drug role
example of usage: http://www.answers.com/topic/drug 1. A substance used in the diagnosis, treatment, or prevention of a disease or as a component of a medication. 2. Such a substance as recognized or defined by the U.S. Food, Drug, and Cosmetic Act.
has curation status: IAO_0000120
has curation status: External
definition: A role borne by a molecular entity and is realized in a process of absorption by an organism alters, or effects (or is assumed to effect) a function(s) which inhere in an organism.
definition: a role borne by a molecular entity and is realized in a process of absorption by an organism alters, or effects (or is assumed to effect) a function(s) which inhere in an organism
definition editor: Role Branch
alternative term: drug
definition source: OBI, CDISC

processed material
type: Class
subclass of: material entity
editor preferred label: processed material
example of usage: Examples include gel matrices, filter paper, parafilm and buffer solutions, mass spectrometer, tissue samples
has curation status: IAO_0000122
definition: Is a material entity that is created or changed during material processing.
definition editor: PERSON: Alan Ruttenberg

quantitative confidence value
type: Class
subclass of: derived data from inferential statistical analysis
editor preferred label: quantitative confidence value
has curation status: IAO_0000125
definition: A data item which is used to indicate the degree of uncertainty about a measurement.
definition editor: person:Chris Stoeckert
definition source: group:OBI
imported from: obi.owl

patient role
type: Class
subclass of: role
editor preferred label: patient role
example of usage: a hospitalized person; a person with controlled diabetes; the patient's role http://www.fertilityjourney.com/testingAndDiagnosis/theRightDoctor/thePatientsRole/index.asp?C=55245395146924652778
has curation status: IAO_0000120
has curation status: External
definition: A role which inheres in a person and is realized by being under the care of a physician or health care provider.
definition: a role which inheres in a person and is realized by being under the care of a physician or health care provider
definition: a role which inheres in a person and is realized by the process of being under the care of a physician or health care provider
editor note: See also OMRSE:00000011 'patient role'
definition editor: GROUP:Role Branch
alternative term: patient
definition source: OBI, CDISC
curator note: CDISC definition: patient. Person under a physician's care for a particular disease or condition. NOTE: A subject in a clinical trial is not necessarily a patient, but a patient in a clinical trial is a subject. See also subject, trial subject, healthy volunteer. Often used interchangeably

material processing
type: Class
subclass of: planned process
editor preferred label: material processing
example of usage: A cell lysis, production of a cloning vector, creating a buffer.
has curation status: IAO_0000122
definition: A planned process which results in physical changes in a specified input material
definition editor: PERSON: Bjoern Peters
definition editor: PERSON: Frank Gibson
definition editor: PERSON: Jennifer Fostel
definition editor: PERSON: Melanie Courtot
definition editor: PERSON: Philippe Rocca Serra
alternative term: material transformation
definition source: OBI branch derived

organisation
type: Class
subclass of: material entity
editor preferred label: organization
example of usage: PMID: 16353909.AAPS J. 2005 Sep 22;7(2):E274-80. Review. The joint food and agriculture organization of the United Nations/World Health Organization Expert Committee on Food Additives and its role in the evaluation of the safety of veterinary drug residues in foods.
has curation status: IAO_0000122
has curation status: External
definition: A material entity which can play roles, has members, and has a set of organization rules. Members of organizations are either organizations themselves or individual people. Members can bear specific organization member roles that are determined in the organization rules. The organization rules also determine how decisions are made on behalf of the organization by the organization members.
definition: An entity that can bear roles, has members, and has a set of organization rules. Members of organizations are either organizations themselves or individual people. Members can bear specific organization member roles that are determined in the organization rules. The organization rules also determine how decisions are made on behalf of the organization by the organization members.
editor note: BP: The definition summarizes long email discussions on the OBI developer, roles, biomaterial and denrie branches. It leaves open if an organization is a material entity or a dependent continuant, as no consensus was reached on that. The current placement as material is therefore temporary, in order to move forward with development. Here is the entire email summary, on which the definition is based: 1) there are organization_member_roles (president, treasurer, branch editor), with individual persons as bearers 2) there are organization_roles (employer, owner, vendor, patent holder) 3) an organization has a charter / rules / bylaws, which specify what roles there are, how they should be realized, and how to modify the charter/rules/bylaws themselves. It is debatable what the organization itself is (some kind of dependent continuant or an aggregate of people). This also determines who/what the bearer of organization_roles' are. My personal favorite is still to define organization as a kind of 'legal entity', but thinking it through leads to all kinds of questions that are clearly outside the scope of OBI. Interestingly enough, it does not seem to matter much where we place organization itself, as long as we can subclass it (University, Corporation, Government Agency, Hospital), instantiate it (Affymetrix, NCBI, NIH, ISO, W3C, University of Oklahoma), and have it play roles. This leads to my proposal: We define organization through the statements 1 - 3 above, but without an 'is a' statement for now. We can leave it in its current place in the is_a hierarchy (material entity) or move it up to 'continuant'. We leave further clarifications to BFO, and close this issue for now.
definition editor: PERSON: Alan Ruttenberg
definition editor: PERSON: Bjoern Peters
definition editor: PERSON: Philippe Rocca-Serra
definition editor: PERSON: Susanna Sansone
alternative term: Organisation
definition source: GROUP: OBI
definition source: OBI:0000245
curator note: The definition from OBI has been slightly changed to refer to 'material entity' rather than 'continuant entity'
label: organization

protocol
type: Class
subclass of: plan specification
editor preferred label: protocol
example of usage: PCR protocol, has objective specification, amplify DNA fragment of interest, and has action specification describes the amounts of experimental reagents used (e..g. buffers, dNTPS, enzyme), and the temperature and cycle time settings for running the PCR.
has curation status: IAO_0000122
has curation status: External
definition: A plan specification which has sufficient level of detail and quantitative information to communicate it between investigation agents, so that different investigation agents will reliably be able to independently reproduce the process.
definition editor: PlanAndPlannedProcess Branch
definition source: OBI branch derived + wikipedia (http://en.wikipedia.org/wiki/Protocol_%28natural_sciences%29)
ISA alternative term: study protocol

extract
type: Class
subclass of: processed material
editor preferred label: extract
example of usage: Up-regulation of inflammatory signalings by areca nut extract and role of cyclooxygenase-2 -1195G>a polymorphism reveal risk of oral cancer. Cancer Res. 2008 Oct 15;68(20):8489-98. PMID: 18922923
has curation status: IAO_0000120
has curation status: External
definition: A processed material that results from an extraction process.
definition: an extract is a material entity which results from an extraction process
definition editor: PERSON: Philippe Rocca-Serra
alternative term: extracted material
definition source: GROUP: OBI Biomatrial Branch

dose
type: Class
subclass of: measurement datum
editor preferred label: dose
example of usage: An organism has been injected 1ml of vaccine
has curation status: IAO_0000123
has curation status: External
definition: A measurement datum that measures the quantity of something that may be administered to an organism or that an organism may be exposed to. Quantities of nutrients, drugs, vaccines and toxins are referred to as doses.

disease
type: Class
subclass of: disposition
has curation status: External
definition: A disposition (i) to undergo pathological processes that (ii) exists in an organism because of one or more disorders in that organism.
definition editor: Albert Goldfain
definition source: http://ontology.buffalo.edu/medo/Disease_and_Diagnosis.pdf
curator note: creation date: 2009-06-23T11:21:20Z

disorder
type: Class
subclass of: material entity
has curation status: External
definition: A material entity which is clinically abnormal and part of an extended organism. Disorders are the physical basis of disease.
definition editor: Albert Goldfain
definition source: http://ontology.buffalo.edu/medo/Disease_and_Diagnosis.pdf
curator note: creation date: 2009-06-23T11:39:44Z

bodily process
type: Class
subclass of: process
example of usage: The phrase 'bodily component of an organism in the definition refers to a part of the body.
has curation status: External
definition: A <process> in which at least one bodily component of an organism participates.
definition: A process in which at least one bodily component of an organism participates.
definition: A process in which at least one bodily component of an organsim participates.
definition editor: Albert Goldfain
definition source: http://www.jbiomedsem.com/content/1/1/10
curator note: creation date: 2009-06-23T11:53:49Z
comment: From OGMS: http://purl.obolibrary.org/obo/OGMS_0000060
comment: The phrase 'bodily component of an organism’ in the definition refers to ‘a part of the body’.

pathological bodily process
type: Class
subclass of: bodily process
definition: A bodily process that is clinically abnormal.
definition editor: Albert Goldfain
definition source: http://ontology.buffalo.edu/medo/Disease_and_Diagnosis.pdf
curator note: creation date: 2009-06-23T11:54:29Z

extended organism
type: Class
subclass of: material entity
definition: An object aggregate consisting of an organism and all material entities located within the organism, overlapping the organism, or occupying sites formed in part by the organism.
definition editor: Albert Goldfain
definition source: http://code.google.com/p/ogms/issues/detail
curator note: creation date: 2010-01-25T04:51:11Z
comment: From OGMS: http://purl.obolibrary.org/obo/OGMS_0000087

treatment
type: Class
subclass of: health care process
has curation status: External
definition: A healthcare process whose completion is hypothesized by a health care provider to eliminate, prevent, or alleviate the signs and symptoms of a disorder or pathological process.
definition: A planned process whose completion is hypothesized by a health care provider to eliminate, prevent, or alleviate a disorder, the signs and symptoms of a disorder, or a pathological process
definition editor: Albert Goldfain
definition source: http://code.google.com/p/ogms/issues/detail
curator note: creation date: 2010-03-31T04:51:11Z

health care process
type: Class
subclass of: planned process
has curation status: External
definition: A planned process with the objective to improve the health status of a patient that directly involves the treatment, diagnosis, or prevention of disease or injury of a patient
definition: A planned process with the objective to improve the health status of a patient that directly involves the treatment, diagnosis, or prevention of disease or injury of a patient.
definition editor: Albert Goldfain Sagar Jain
definition source: http://groups.google.com/group/ogms-discuss/browse_thread/thread/a2dbc2ed1dff99d6
curator note: creation date: 2011-02-21T09:57:44Z editor date: 2017-04-18

injury
type: Class
subclass of: disorder
definition: A disorder that involves some structural damage that is immediately caused by a catastrophic external force.
editor note: At the scale of organism (as opposed to the cellular scale or the population scale), an injury is typically the result of a catastrophic event. Consider the implications of making 'injury' a subtype of 'disorder'. Note: Adopted subtype of disorder, and injury can occur at the scale of organism down to cellular level.
definition editor: Albert Goldfain Sagar Jain
definition source: http://groups.google.com/group/ogms-discuss/browse_thread/thread/ca0ad373f27774c5 OGMS call adoption- 16 SEPT 2015 https://docs.google.com/document/d/1iiV1-fTS7BUUSzDw3N_Afx42698YWf54-FOTY2NkAxo/edit
curator note: creation date: 2011-09-20T09:57:44Z edited date: 30 SEPT 2015

architectural structure
type: Class
subclass of: material entity
has curation status: External
definition: A material entity that is a human made strcuture with firm connection between its foundation and the ground.
definition: A material entity that is a human made structure with firm connection between its foundation and the ground.
definition editor: Mathias Brochhausen
definition source: http://de.wikipedia.org/wiki/Bauwerk
comment: "Building" is a subclass of this.
comment: This type of entity is referred to as "Bauwerk" or "Bauliche Anlage".

facility
type: Class
subclass of: architectural structure
subclass of: Restriction
  on property: part of
  some values from: environmental system
has curation status: External
definition: An architectural structure that bears some function.
definition editor: Mathias Brochhausen
definition source: Ontology of Medically Related Social Entities

hospital facility
type: Class
subclass of: health care facility
has curation status: External
definition: A facility that is run by a hospital organization, such as emergency departments, outpatient clinics and rehabilitation and is the bearer of a hospital function
definition: A health care facility that bears the function to provide acute and intensive healthcare services and that is run by a hospital organization and is the bearer of a hospital function.
definition: A health care facility that is run by a hospital organization, such as emergency departments, outpatient clinics and rehabilitation and is the bearer of a hospital function.
definition editor: Mathias Brochhausen
definition editor: William Hogan
definition source: Ontology of Medically Related Social Entities

health care facility
type: Class
subclass of: facility
has curation status: External
definition: A facility bearing the function to provide healthcare and that is administered by a health care organization for the purpose of providing health care to a patient or patient population.
definition: A facility that is administered by a health care organization for the purpose of providing health care to a patient or patient population.
definition: A facility that’s administered by a health care organisation for the purpose of providing health care to a patient population
definition editor: A facility bearing the function to provide healthcare and that is administered by a health care organization for the purpose of providing health care to a patient or patient population.
definition editor: William Hogan
definition source: Ontology of Medically Related Social Entities

rehabilitation facility
type: Class
subclass of: community living health care facility
definition: A facility to assist in physical or addiction recovery
definition editor: Amanda Hicks
definition editor: Emma Norris
definition editor: William Hogan
definition source: Human Behaviour Change Project

emergency department facility
type: Class
subclass of: health care facility
has curation status: External
definition: A health care facility that bears a function to provide emergency healthcare services and the acute care of patients who present without prior appointment, having arrived either by their own means or by ambulance
definition: A health care facility that bears a function to provide emergency healthcare services and the acute care of patients who present without prior appointment, having arrived either by their own means or by ambulance.
definition editor: Amanda Hicks
definition editor: Emma Norris
definition editor: William Hogan
definition source: Adapted from Human Behaviour Change Project

community living health care facility
type: Class
subclass of: health care facility
definition: a health care facility that also bears a residence function and thus one in which the patients are also residents of the facility

residential facility
type: Class
subclass of: facility
editor preferred label: residential facility
has curation status: External
definition: A facility that has at least one housing unit as part in which a person or persons live
definition: A facility that has at least one housing unit as part in which a person or persons live.
definition editor: Emma Norris
definition editor: William Hogan
definition source: Modified version of definition provided by Human Behaviour Change Project

quality
type: Class
subclass of: specifically dependent continuant
definition: A dependent entity that inheres in a bearer by virtue of how the bearer is related to other entities
has_alternative_id: PATO:0000072
has_obo_namespace: quality
id: PATO:0000001

Axiom
annotated source: quality
annotated property: definition
annotated target: A dependent entity that inheres in a bearer by virtue of how the bearer is related to other entities
database_cross_reference: PATOC:GVG

age
type: Class
subclass of: time
definition: A time quality inhering in a bearer by virtue of how long the bearer has existed.
has_obo_namespace: quality
id: PATO:0000011
in_subset: attribute slim
in_subset: scalar slim

Axiom
annotated source: age
annotated property: definition
annotated target: A time quality inhering in a bearer by virtue of how long the bearer has existed.
database_cross_reference: WordNet:WordNet

concentration
type: Class
subclass of: amount
subclass of: molecular quality
has curation status: External
definition: A quality inhering in a substance by virtue of the amount of the bearer's there is mixed with another substance.
has exact synonym: concentration
has_obo_namespace: quality
id: PATO:0000033
in_subset: attribute slim
in_subset: relational slim
in_subset: scalar slim
label: concentration of

Axiom
annotated source: concentration
annotated property: definition
annotated target: A quality inhering in a substance by virtue of the amount of the bearer's there is mixed with another substance.
database_cross_reference: Wikipedia:http://en.wikipedia.org/wiki/concentration

amount
type: Class
subclass of: quantitative
definition: The number of entities of this type that are part of the whole organism.
has_alternative_id: PATO:0000053
has_alternative_id: PATO:0000071
has_alternative_id: PATO:0001169
has_alternative_id: PATO:0001226
has exact synonym: presence or absence in organism
has exact synonym: quantitative
has_obo_namespace: quality
has_related_synonym: count in organism
has_related_synonym: number
has_related_synonym: presence
id: PATO:0000070
in_subset: attribute slim
comment: This term was originally named "presence". It has been renamed to reduce ambiguity. Consider annotating with the reciprocal relation,PATO:0001555, has_number_of. For example, rather than E=fin ray Q=count in organism C=10, say E=organism Q=has number of E2= fin ray C=10.

Axiom
annotated source: amount
annotated property: definition
annotated target: The number of entities of this type that are part of the whole organism.
database_cross_reference: PATOC:GVG

time
type: Class
subclass of: physical quality
definition: A quality in which events occur in sequence.
has_obo_namespace: quality
id: PATO:0000165
in_subset: attribute slim
in_subset: scalar slim

Axiom
annotated source: time
annotated property: definition
annotated target: A quality in which events occur in sequence.
database_cross_reference: PATOC:GVG

physical quality
type: Class
subclass of: physical object quality
definition: A quality of a physical entity that exists through action of continuants at the physical level of organisation in relation to other entities.
has_alternative_id: PATO:0002079
database_cross_reference: Wikipedia:Physical_property
has exact synonym: relational physical quality
has_obo_namespace: quality
id: PATO:0001018
in_subset: attribute slim

Axiom
annotated source: physical quality
annotated property: definition
annotated target: A quality of a physical entity that exists through action of continuants at the physical level of organisation in relation to other entities.
database_cross_reference: PATOC:GVG

physical object quality
type: Class
subclass of: quality
definition: A quality which inheres in a continuant.
has_alternative_id: PATO:0001237
has_alternative_id: PATO:0001238
database_cross_reference: snap:Quality
has exact synonym: monadic quality of a continuant
has exact synonym: multiply inhering quality of a physical entity
has exact synonym: quality of a continuant
has exact synonym: quality of a single physical entity
has exact synonym: quality of an object
has exact synonym: quality of continuant
has_narrow_synonym: monadic quality of an object
has_narrow_synonym: monadic quality of continuant
has_obo_namespace: quality
id: PATO:0001241
comment: Relational qualities are qualities that hold between multiple entities. Normal (monadic) qualities such as the shape of a eyeball exist purely as a quality of that eyeball. A relational quality such as sensitivity to light is a quality of that eyeball (and connecting nervous system) as it relates to incoming light waves/particles.

Axiom
annotated source: physical object quality
annotated property: definition
annotated target: A quality which inheres in a continuant.
database_cross_reference: PATOC:GVG

molecular quality
type: Class
subclass of: physical object quality
definition: A quality which inheres in a molecular entity, a single molecule, atom, ion, radical etc.
contributor: 0000-0002-2061-091X
creation date: 2010-03-10T03:18:15Z
has_alternative_id: PATO:0002061
has exact synonym: relational molecular quality
has_obo_namespace: quality
id: PATO:0002182

Axiom
annotated source: molecular quality
annotated property: definition
annotated target: A quality which inheres in a molecular entity, a single molecule, atom, ion, radical etc.
database_cross_reference: PATOC:GVG

quantitative
type: Class
subclass of: quality
definition: A quality of an entity that can be represented numerically, including anything that can be counted, measured, or given a numerical value.
created by: https://orcid.org/0000-0001-8314-2140
has_obo_namespace: quality
id: PATO:0103000

Axiom
annotated source: quantitative
annotated property: definition
annotated target: A quality of an entity that can be represented numerically, including anything that can be counted, measured, or given a numerical value.
database_cross_reference: https://libguides.macalester.edu/c.php
database_cross_reference: https://www.nnlm.gov/guides/data-glossary/quantitative-data

whole plant
type: Class
subclass of: plant anatomical entity
has curation status: External
definition: A plant structure (PO:0005679) which is a whole organism.
definition: A plant structure which is a whole organism.
has_broad_synonym: genet (broad)
has_broad_synonym: ramet (broad)
database_cross_reference: PO_GIT:538
database_cross_reference: PO_GIT:69
has exact synonym: planta entera (Spanish, exact)
has exact synonym: 植物体全体 (Japanese, exact)
has_narrow_synonym: bush (narrow)
has_narrow_synonym: frutex (narrow)
has_narrow_synonym: frutices (narrow, plural)
has_narrow_synonym: gametophyte (narrow)
has_narrow_synonym: herb (narrow)
has_narrow_synonym: liana (narrow)
has_narrow_synonym: prothalli (narrow, plural)
has_narrow_synonym: prothallium (narrow)
has_narrow_synonym: prothallus (narrow)
has_narrow_synonym: shrub (narrow)
has_narrow_synonym: sporophyte (narrow)
has_narrow_synonym: suffrutex (narrow)
has_narrow_synonym: suffrutices (narrow, plural)
has_narrow_synonym: tree (narrow)
has_narrow_synonym: vine (narrow)
has_narrow_synonym: woody clump (narrow)
has_obo_namespace: plant_anatomy
has_related_synonym: clonal colony (related)
has_related_synonym: colony (related)
id: PO:0000003
in_subset: TraitNet
in_subset: reference
comment: Examples include plant embryo (PO:0009009), megagametophyte (PO:0025279) and microgametophyte (PO:0025280).

Axiom
annotated source: whole plant
annotated property: definition
annotated target: A plant structure (PO:0005679) which is a whole organism.
database_cross_reference: POC:curators

Axiom
annotated source: whole plant
annotated property: has exact synonym
annotated target: planta entera (Spanish, exact)
database_cross_reference: POC:Maria_Alejandra_Gandolfo
has synonym type: Spanish

Axiom
annotated source: whole plant
annotated property: has exact synonym
annotated target: 植物体全体 (Japanese, exact)
database_cross_reference: NIG:Yukiko_Yamazaki
has synonym type: Japanese

Axiom
annotated source: whole plant
annotated property: has_narrow_synonym
annotated target: frutex (narrow)

Axiom
annotated source: whole plant
annotated property: has_narrow_synonym
annotated target: frutices (narrow, plural)
has synonym type: OMO_0003004

Axiom
annotated source: whole plant
annotated property: has_narrow_synonym
annotated target: prothalli (narrow, plural)
has synonym type: OMO_0003004

Axiom
annotated source: whole plant
annotated property: has_narrow_synonym
annotated target: prothallus (narrow)

Axiom
annotated source: whole plant
annotated property: has_narrow_synonym
annotated target: suffrutex (narrow)

Axiom
annotated source: whole plant
annotated property: has_narrow_synonym
annotated target: suffrutices (narrow, plural)
has synonym type: OMO_0003004

Axiom
annotated source: whole plant
annotated property: has_narrow_synonym
annotated target: woody clump (narrow)

plant anatomical entity
type: Class
subclass of: object
definition: An anatomical entity that is or was part of a plant.
created by: rwalls
creation date: 2010-11-15T11:41:38Z
database_cross_reference: PO_GIT:224
has exact synonym: entidad anat&#243mica vegetal (Spanish, exact)
has exact synonym: 植物 解剖学（形態）的実体 (Japanese, exact)
has_obo_namespace: plant_anatomy
id: PO:0025131
comment: Includes both material entities such as plant structures and immaterial entities such as plant anatomical spaces. CARO:0000000 'anatomical entity' is defined as: A part of a cellular organism that is either an immaterial entity or a material entity with granularity aboove the level of a protein complex. Or, a substance produced by a cellular organism with granularity above the level of a protein complex. Refers to BFO:0000004 'independent continuant'.

Axiom
annotated source: plant anatomical entity
annotated property: definition
annotated target: An anatomical entity that is or was part of a plant.
database_cross_reference: BFO:0000004
database_cross_reference: CARO:0000000
database_cross_reference: CAROC:Brownsville2014
database_cross_reference: POC:curators

Axiom
annotated source: plant anatomical entity
annotated property: has exact synonym
annotated target: entidad anat&#243mica vegetal (Spanish, exact)
database_cross_reference: POC:Maria_Alejandra_Gandolfo
has synonym type: Spanish

Axiom
annotated source: plant anatomical entity
annotated property: has exact synonym
annotated target: 植物 解剖学（形態）的実体 (Japanese, exact)
database_cross_reference: NIG:Yukiko_Yamazaki
has synonym type: Japanese

system
type: Class
subclass of: material entity
definition: A material entity consisting of multiple components that are causally integrated.
editor note: May be replaced by a BFO class, as discussed in http://www.jbiomedsem.com/content/4/1/43
definition editor: https://orcid.org/0000-0002-6601-2165
definition source: http://www.jbiomedsem.com/content/4/1/43

research activity
type: Class
subclass of: planned process
has curation status: External
definition: A planned process executed in the performance of scientific research wherein systematic investigations are performed to establish facts and reach new conclusions about phenomena in the world.
alternative term: research
comment: Data generation process are typically experimental studies or observations, but can include any process generating information used to evaluate a claim. This is an organizational class that groups more specific types of such processes that are most commonly used in generating data used as evidence to support claims. These processes produce informational artifacts such as measured data values, derived statistical calculations and confidence measures, or statements representing summaries or conclusions drawn from such data.

research study
type: Class
subclass of: research activity
has curation status: External
definition: A planned process that executes some study design or protocol to generate scientific data that is interpreted to test or generate a hypothesis.
SEPIO_editor_note: Explore the classification of study types here as a possibility to implement in SEPIO. https://mcw.libguides.com/evidencebased/studies Useful because these map to the strength of the evidence each might provide.
comment: A research study is considered broadly to be any scientific activity aimed at answering a research question. Studies can be simple or complex, depending on the scope of the question being explored and the extent of resources deployed in doing so. They may include a full research investigation, a set of experiments, or a single experiment or assay. Regardless, that act of summarizing any results as a finding statement is considered part of the study.
comment: A research study is considered broadly to be any scientific activity aimed at answering a research question. Studies can be simple or complex, depending on the scope of the question being explored and the extent of resources deployed in doing so. They may include a full research investigation, a set of related experiments, or a single experiment or assay. Regardless, that act of summarizing any results as a finding statement is considered part of the study. 'Study' here is broadly considered to include any defined activity performed to address a scientific question or generate a scientific hypothesis. It covers scientific inquiry at different scales of complexity, from a single assay, experiment or observation, to a complex research investigation addressing a broader scientific question. Studies can be based on a broad range of methods, including in silico algorithms, in vitro or in vivo experimentation on model systems, clinical studies on human subjects, or curation and analysis of existing knowledge, e.g. from publications, datasets, or knowledegbases, to derive novel insight.

processual entity
type: Class
subclass of: occurrent
definition: An occurrent [span:Occurrent] that exists in time by occurring or happening, has temporal parts and always involves and depends on some entity.
present in taxon: NCBITaxon_33090
present in taxon: NCBITaxon_33208
present in taxon: NCBITaxon 4751
database_cross_reference: BFO:0000003
id: UBERON:0000000
in_subset: common anatomy
in_subset: human subset
in_subset: mouse subset
in_subset: upper level
comment: This term is being aligned with COB

Axiom
annotated source: processual entity
annotated property: definition
annotated target: An occurrent [span:Occurrent] that exists in time by occurring or happening, has temporal parts and always involves and depends on some entity.
database_cross_reference: span:ProcessualEntity

anatomical structure
type: Class
subclass of: material anatomical entity
definition: Material anatomical entity that is a single connected structure with inherent 3D shape generated by coordinated expression of the organism's own genome.
present in taxon: NCBITaxon_33090
present in taxon: NCBITaxon_33208
present in taxon: NCBITaxon 4751
present in taxon: NCBITaxon 9606
database_cross_reference: AAO:0010825
database_cross_reference: AEO:0000003
database_cross_reference: BILA:0000003
database_cross_reference: CARO:0000003
database_cross_reference: EHDAA2:0003003
database_cross_reference: EMAPA:0
database_cross_reference: FAO:0000001
database_cross_reference: FBbt:00007001
database_cross_reference: FMA:305751
database_cross_reference: FMA:67135
database_cross_reference: GAID:781
database_cross_reference: HAO:0000003
database_cross_reference: MA:0003000
database_cross_reference: MESH:D000825
database_cross_reference: SCTID:362889002
database_cross_reference: TAO:0000037
database_cross_reference: TGMA:0001823
database_cross_reference: VHOG:0001759
database_cross_reference: XAO:0003000
database_cross_reference: ZFA:0000037
database_cross_reference: http://dbpedia.org/ontology/AnatomicalStructure
has exact synonym: biological structure
has exact synonym: connected biological structure
id: UBERON:0000061
in_subset: common anatomy
in_subset: human reference atlas
in_subset: human subset
in_subset: mouse subset
in_subset: upper level

Axiom
annotated source: anatomical structure
annotated property: definition
annotated target: Material anatomical entity that is a single connected structure with inherent 3D shape generated by coordinated expression of the organism's own genome.
database_cross_reference: CARO:0000003

Axiom
annotated source: anatomical structure
annotated property: database_cross_reference
annotated target: FBbt:00007001
mapping justification: ManualMappingCuration

Axiom
annotated source: anatomical structure
annotated property: has exact synonym
annotated target: connected biological structure
database_cross_reference: CARO:0000003

organ
type: Class
subclass of: multicellular anatomical structure
has curation status: External
definition: Anatomical structure that performs a specific function or group of functions
definition: Anatomical structure that performs a specific function or group of functions [WP].
never in taxon: NCBITaxon_110815
present in taxon: NCBITaxon_33090
present in taxon: NCBITaxon_33208
present in taxon: NCBITaxon 4751
external_definition: Organs are commonly observed as visibly distinct structures, but may also exist as loosely associated clusters of cells that work together to perform a specific function or functions.
external_ontology_notes: CARO v1 does not include a generic 'organ' class, only simple and compound organ. CARO v2 may include organ, see https://github.com/obophenotype/caro/issues/4
database_cross_reference: BIRNLEX:4
database_cross_reference: CARO:0020004
database_cross_reference: EFO:0000634
database_cross_reference: EMAPA:35949
database_cross_reference: ENVO:01000162
database_cross_reference: FMA:67498
database_cross_reference: MA:0003001
database_cross_reference: NCIT:C13018
database_cross_reference: SCTID:272625005
database_cross_reference: UMLS:C0178784
database_cross_reference: WBbt:0003760
database_cross_reference: Wikipedia:Organ_(anatomy)
has_related_synonym: anatomical unit
has_related_synonym: body organ
has_related_synonym: element
id: UBERON:0000062
in_subset: common anatomy
in_subset: human subset
in_subset: mouse subset
in_subset: upper level

Axiom
annotated source: organ
annotated property: definition
annotated target: Anatomical structure that performs a specific function or group of functions [WP].
database_cross_reference: Wikipedia:Organ_(anatomy)

Axiom
annotated source: organ
annotated property: never in taxon
annotated target: NCBITaxon_110815
source: Wikipedia

Axiom
annotated source: organ
annotated property: external_definition
annotated target: Organs are commonly observed as visibly distinct structures, but may also exist as loosely associated clusters of cells that work together to perform a specific function or functions.
source: GO:0048513

Axiom
annotated source: organ
annotated property: database_cross_reference
annotated target: UMLS:C0178784
source: ncithesaurus:Organ

Axiom
annotated source: organ
annotated property: has_related_synonym
annotated target: element
database_cross_reference: http://orcid.org/0000-0002-6601-2165

death
type: Class
subclass of: life cycle stage
has curation status: External
definition: End of the life of an organism.
present in taxon: NCBITaxon_33090
present in taxon: NCBITaxon_33208
present in taxon: NCBITaxon 4751
external_ontology_notes: ncit:Death is an outcome
database_cross_reference: XAO:0000437
database_cross_reference: XtroDO:0000085
has_related_synonym: death
id: UBERON:0000071
in_subset: common anatomy
in_subset: human subset
in_subset: mouse subset
label: death stage

Axiom
annotated source: death
annotated property: definition
annotated target: End of the life of an organism.
database_cross_reference: XAO:0000437

Axiom
annotated source: death
annotated property: external_ontology_notes
annotated target: ncit:Death is an outcome
external ontology: ncit

life cycle stage
type: Class
subclass of: processual entity
definition: A spatiotemporal region encompassing some part of the life cycle of an organism.
editor note: this class represents a proper part of the life cycle of an organism. The class 'life cycle' should not be placed here
present in taxon: NCBITaxon_33090
present in taxon: NCBITaxon_33208
present in taxon: NCBITaxon 4751
external_ontology_notes: the WBls class 'all stages' belongs here as it is the superclass of other WBls stages
external_ontology_notes: we map the ZFS unknown stage here as it is logically equivalent to saying *some* life cycle stage
database_cross_reference: AcarDv:0000000
database_cross_reference: BILS:0000105
database_cross_reference: BtauDv:0000000
database_cross_reference: CfamDv:0000000
database_cross_reference: ChirDv:0000000
database_cross_reference: CporDv:0000000
database_cross_reference: DpseDv:0000000
database_cross_reference: DsimDv:0000000
database_cross_reference: EFO:0000399
database_cross_reference: EcabDv:0000000
database_cross_reference: FBdv:00007012
database_cross_reference: FMA:24120
database_cross_reference: FcatDv:0000000
database_cross_reference: GgalDv:0000000
database_cross_reference: GgorDv:0000000
database_cross_reference: HsapDv:0000000
database_cross_reference: MESH:D008018
database_cross_reference: MdomDv:0000000
database_cross_reference: MmulDv:0000000
database_cross_reference: MmusDv:0000000
database_cross_reference: OanaDv:0000000
database_cross_reference: OariDv:0000000
database_cross_reference: OcunDv:0000000
database_cross_reference: PdumDv:0000090
database_cross_reference: PpanDv:0000000
database_cross_reference: PtroDv:0000000
database_cross_reference: RnorDv:0000000
database_cross_reference: SsalDv:0000000
database_cross_reference: SscrDv:0000000
database_cross_reference: WBls:0000002
database_cross_reference: XAO:1000000
database_cross_reference: ZFS:0000000
database_cross_reference: ZFS:0100000
database_cross_reference: ncithesaurus:Developmental_Stage
has_narrow_synonym: developmental stage
has_narrow_synonym: stage
id: UBERON:0000105
in_subset: common anatomy
in_subset: efo slim
in_subset: human subset
in_subset: mouse subset
in_subset: upper level

Axiom
annotated source: life cycle stage
annotated property: definition
annotated target: A spatiotemporal region encompassing some part of the life cycle of an organism.
database_cross_reference: https://orcid.org/0000-0002-6601-2165

Axiom
annotated source: life cycle stage
annotated property: database_cross_reference
annotated target: AcarDv:0000000
mapping justification: UnspecifiedMatching

Axiom
annotated source: life cycle stage
annotated property: database_cross_reference
annotated target: BtauDv:0000000
mapping justification: UnspecifiedMatching

Axiom
annotated source: life cycle stage
annotated property: database_cross_reference
annotated target: CfamDv:0000000
mapping justification: UnspecifiedMatching

Axiom
annotated source: life cycle stage
annotated property: database_cross_reference
annotated target: ChirDv:0000000
mapping justification: UnspecifiedMatching

Axiom
annotated source: life cycle stage
annotated property: database_cross_reference
annotated target: CporDv:0000000
mapping justification: UnspecifiedMatching

Axiom
annotated source: life cycle stage
annotated property: database_cross_reference
annotated target: DpseDv:0000000
mapping justification: UnspecifiedMatching

Axiom
annotated source: life cycle stage
annotated property: database_cross_reference
annotated target: DsimDv:0000000
mapping justification: UnspecifiedMatching

Axiom
annotated source: life cycle stage
annotated property: database_cross_reference
annotated target: EcabDv:0000000
mapping justification: UnspecifiedMatching

Axiom
annotated source: life cycle stage
annotated property: database_cross_reference
annotated target: FcatDv:0000000
mapping justification: UnspecifiedMatching

Axiom
annotated source: life cycle stage
annotated property: database_cross_reference
annotated target: GgalDv:0000000
mapping justification: UnspecifiedMatching

Axiom
annotated source: life cycle stage
annotated property: database_cross_reference
annotated target: GgorDv:0000000
mapping justification: UnspecifiedMatching

Axiom
annotated source: life cycle stage
annotated property: database_cross_reference
annotated target: HsapDv:0000000
mapping justification: UnspecifiedMatching

Axiom
annotated source: life cycle stage
annotated property: database_cross_reference
annotated target: MdomDv:0000000
mapping justification: UnspecifiedMatching

Axiom
annotated source: life cycle stage
annotated property: database_cross_reference
annotated target: MmulDv:0000000
mapping justification: UnspecifiedMatching

Axiom
annotated source: life cycle stage
annotated property: database_cross_reference
annotated target: MmusDv:0000000
mapping justification: UnspecifiedMatching

Axiom
annotated source: life cycle stage
annotated property: database_cross_reference
annotated target: OanaDv:0000000
mapping justification: UnspecifiedMatching

Axiom
annotated source: life cycle stage
annotated property: database_cross_reference
annotated target: OariDv:0000000
mapping justification: UnspecifiedMatching

Axiom
annotated source: life cycle stage
annotated property: database_cross_reference
annotated target: OcunDv:0000000
mapping justification: UnspecifiedMatching

Axiom
annotated source: life cycle stage
annotated property: database_cross_reference
annotated target: PpanDv:0000000
mapping justification: UnspecifiedMatching

Axiom
annotated source: life cycle stage
annotated property: database_cross_reference
annotated target: PtroDv:0000000
mapping justification: UnspecifiedMatching

Axiom
annotated source: life cycle stage
annotated property: database_cross_reference
annotated target: RnorDv:0000000
mapping justification: UnspecifiedMatching

Axiom
annotated source: life cycle stage
annotated property: database_cross_reference
annotated target: SsalDv:0000000
mapping justification: UnspecifiedMatching

Axiom
annotated source: life cycle stage
annotated property: database_cross_reference
annotated target: SscrDv:0000000
mapping justification: UnspecifiedMatching

neural nucleus
type: Class
subclass of: central nervous system cell part cluster
definition: A spatially aggregated collection of nerve cell bodies in the CNS, consisting of one or more subpopulations that share cell type, chemical phenotype, and connections, and including nearby cells that share the same cell type, chemical phenotype, and connections. (CUMBO).
external_definition: Anatomical structure consisting of a discrete aggregate of neuronal soma[GO][GO_REF:0000021].
external_ontology_notes: Proposed CUMBO def from MM: A subcortical part of the nervous system consisting of a relatively compact group of cells that is distinguishable histologically that share a commonality of cytoarchitecture, chemoarchitecturel and connectivity. (comments: I put in 'subcortical' because I don't think we consider either the cerebellar cortex or cerebral cortex to be nuclei. Some people distinguish between a nucleus and a laminar structure (see Wikipedia definition). However, there are structures identified as nuclei that are laminar, e.g., lateral geniculate nucleus, although they are not laminated in all species. Also, I put in 'relatively compact' and 'distiguishable by histology' because we have groups of cells, e.g., cholinergic cell groups, doparminergic cell groups that are related on the 3 criteria but which we don't tend to consider nuclei because they don't occupy an easily defined territory. But all is open to debate.
has_broad_synonym: nucleus
database_cross_reference: AEO:0000136
database_cross_reference: FMA:83686
database_cross_reference: NCIT:C13197
database_cross_reference: NLX:28443
database_cross_reference: Wikipedia:Nucleus_(neuroanatomy)
has exact synonym: nervous system nucleus
has exact synonym: neuraxis nucleus
has exact synonym: neuronal nucleus
has exact synonym: nucleus of CNS
has_related_synonym: nucleus of neuraxis
id: UBERON:0000125
in_subset: cumbo
in_subset: human subset
in_subset: mouse subset

Axiom
annotated source: neural nucleus
annotated property: definition
annotated target: A spatially aggregated collection of nerve cell bodies in the CNS, consisting of one or more subpopulations that share cell type, chemical phenotype, and connections, and including nearby cells that share the same cell type, chemical phenotype, and connections. (CUMBO).
database_cross_reference: NLX:28443

Axiom
annotated source: neural nucleus
annotated property: external_definition
annotated target: Anatomical structure consisting of a discrete aggregate of neuronal soma[GO][GO_REF:0000021].
source: GO_REF:0000021

Axiom
annotated source: neural nucleus
annotated property: has exact synonym
annotated target: neuraxis nucleus
database_cross_reference: FMA:83686

Axiom
annotated source: neural nucleus
annotated property: has exact synonym
annotated target: neuronal nucleus
database_cross_reference: AEO:0000136

Axiom
annotated source: neural nucleus
annotated property: has exact synonym
annotated target: nucleus of CNS
database_cross_reference: NLX:28443

organism substance
type: Class
subclass of: material anatomical entity
definition: Material anatomical entity in a gaseous, liquid, semisolid or solid state; produced by anatomical structures or derived from inhaled and ingested substances that have been modified by anatomical structures as they pass through the body.
present in taxon: NCBITaxon_33090
present in taxon: NCBITaxon_33208
present in taxon: NCBITaxon 4751
database_cross_reference: AAO:0010839
database_cross_reference: AEO:0000004
database_cross_reference: BILA:0000004
database_cross_reference: CALOHA:TS-2101
database_cross_reference: CARO:0000004
database_cross_reference: EHDAA2:0003004
database_cross_reference: EMAPA:35178
database_cross_reference: FBbt:00007019
database_cross_reference: FMA:9669
database_cross_reference: HAO:0000004
database_cross_reference: MA:0002450
database_cross_reference: NCIT:C13236
database_cross_reference: SPD:0000008
database_cross_reference: TAO:0001487
database_cross_reference: TGMA:0001824
database_cross_reference: VHOG:0001726
database_cross_reference: XAO:0004001
database_cross_reference: ZFA:0001487
database_cross_reference: galen:BodySubstance
has exact synonym: body fluid or substance
has exact synonym: body substance
has exact synonym: organism substance
has exact synonym: portion of body substance
has exact synonym: portion of organism substance
id: UBERON:0000463
in_subset: common anatomy
in_subset: human subset
in_subset: mouse subset
in_subset: pheno slim
in_subset: upper level

Axiom
annotated source: organism substance
annotated property: definition
annotated target: Material anatomical entity in a gaseous, liquid, semisolid or solid state; produced by anatomical structures or derived from inhaled and ingested substances that have been modified by anatomical structures as they pass through the body.
database_cross_reference: http://orcid.org/0000-0001-9114-8737

Axiom
annotated source: organism substance
annotated property: database_cross_reference
annotated target: FBbt:00007019
mapping justification: ManualMappingCuration

Axiom
annotated source: organism substance
annotated property: has exact synonym
annotated target: body fluid or substance
database_cross_reference: MA:0002450

Axiom
annotated source: organism substance
annotated property: has exact synonym
annotated target: body substance
database_cross_reference: FMA:9669

Axiom
annotated source: organism substance
annotated property: has exact synonym
annotated target: organism substance
database_cross_reference: CARO:0000004

Axiom
annotated source: organism substance
annotated property: has exact synonym
annotated target: portion of body substance
database_cross_reference: FMA:9669

Axiom
annotated source: organism substance
annotated property: has exact synonym
annotated target: portion of organism substance
database_cross_reference: ZFA:0001487

material anatomical entity
type: Class
subclass of: anatomical entity
definition: Anatomical entity that has mass.
present in taxon: NCBITaxon_33090
present in taxon: NCBITaxon_33208
present in taxon: NCBITaxon 4751
database_cross_reference: AAO:0010264
database_cross_reference: AEO:0000006
database_cross_reference: BILA:0000006
database_cross_reference: CARO:0000006
database_cross_reference: EHDAA2:0003006
database_cross_reference: FBbt:00007016
database_cross_reference: FMA:67165
database_cross_reference: HAO:0000006
database_cross_reference: TAO:0001836
database_cross_reference: TGMA:0001826
database_cross_reference: VHOG:0001721
id: UBERON:0000465
in_subset: common anatomy
in_subset: human subset
in_subset: mouse subset
in_subset: upper level

Axiom
annotated source: material anatomical entity
annotated property: definition
annotated target: Anatomical entity that has mass.
database_cross_reference: http://orcid.org/0000-0001-9114-8737

Axiom
annotated source: material anatomical entity
annotated property: database_cross_reference
annotated target: FBbt:00007016
mapping justification: ManualMappingCuration

anatomical system
type: Class
subclass of: anatomical structure
has curation status: External
definition: Multicellular, connected anatomical structure that has multiple organs as parts and whose parts work together to achieve some shared function.
alternative term: Organ system
present in taxon: NCBITaxon_33090
present in taxon: NCBITaxon_33208
present in taxon: NCBITaxon 4751
present in taxon: NCBITaxon 9606
has_broad_synonym: system
database_cross_reference: AAO:0000007
database_cross_reference: AEO:0000011
database_cross_reference: BILA:0000011
database_cross_reference: BIRNLEX:14
database_cross_reference: BSA:0000049
database_cross_reference: CALOHA:TS-2088
database_cross_reference: CARO:0000011
database_cross_reference: EHDAA2:0003011
database_cross_reference: EHDAA:392
database_cross_reference: EMAPA:16103
database_cross_reference: EV:0100000
database_cross_reference: FBbt:00004856
database_cross_reference: FMA:7149
database_cross_reference: HAO:0000011
database_cross_reference: IDOMAL:0002460
database_cross_reference: MA:0000003
database_cross_reference: NCIT:C12919
database_cross_reference: SCTID:278195005
database_cross_reference: TAO:0001439
database_cross_reference: TGMA:0001831
database_cross_reference: UMLS:C0460002
database_cross_reference: VHOG:0001725
database_cross_reference: WBbt:0005746
database_cross_reference: WBbt:0005763
database_cross_reference: Wikipedia:Organ_system
database_cross_reference: XAO:0003002
database_cross_reference: ZFA:0001439
database_cross_reference: galen:AnatomicalSystem
has exact synonym: body system
has exact synonym: connected anatomical system
has exact synonym: organ system
has_related_synonym: anatomical systems
id: UBERON:0000467
in_subset: common anatomy
in_subset: human reference atlas
in_subset: human subset
in_subset: mouse subset
in_subset: pheno slim
in_subset: uberon slim
in_subset: upper level

Axiom
annotated source: anatomical system
annotated property: definition
annotated target: Multicellular, connected anatomical structure that has multiple organs as parts and whose parts work together to achieve some shared function.
database_cross_reference: CARO:0000011

Axiom
annotated source: anatomical system
annotated property: has_broad_synonym
annotated target: system
database_cross_reference: GO:0048731

Axiom
annotated source: anatomical system
annotated property: database_cross_reference
annotated target: FBbt:00004856
mapping justification: ManualMappingCuration

Axiom
annotated source: anatomical system
annotated property: database_cross_reference
annotated target: IDOMAL:0002460
authored by: https://orcid.org/0000-0003-4423-4370
mapping justification: ManualMappingCuration
mapping provider: https://github.com/biopragmatics/biomappings

Axiom
annotated source: anatomical system
annotated property: database_cross_reference
annotated target: UMLS:C0460002
source: ncithesaurus:Organ_System

Axiom
annotated source: anatomical system
annotated property: has exact synonym
annotated target: body system
database_cross_reference: BIRNLEX:14

Axiom
annotated source: anatomical system
annotated property: has exact synonym
annotated target: connected anatomical system
database_cross_reference: CARO:0000011

Axiom
annotated source: anatomical system
annotated property: has_related_synonym
annotated target: anatomical systems
database_cross_reference: ZFA:0001439
has synonym type: OMO_0003004

respiratory system
type: Class
subclass of: anatomical system
has curation status: External
definition: Functional system which consists of structures involved in respiration.
never in taxon: NCBITaxon_147099
present in taxon: NCBITaxon 9606
external_definition: The anatomical system in which the exchange of oxygen and carbon dioxide between the organism and its environment.[AAO]
homology_notes: There is no doubt that the primitive pattern of vertebrate air-breathing is the buccal pulse pump found in actinopterygian fishes.[well established][VHOG]
database_cross_reference: AAO:0000541
database_cross_reference: BTO:0000203
database_cross_reference: CALOHA:TS-1319
database_cross_reference: EFO:0000804
database_cross_reference: EHDAA2:0001604
database_cross_reference: EHDAA:2203
database_cross_reference: EMAPA:16727
database_cross_reference: EV:0100036
database_cross_reference: FMA:7158
database_cross_reference: GAID:78
database_cross_reference: MA:0000327
database_cross_reference: MAT:0000030
database_cross_reference: MESH:D012137
database_cross_reference: MIAA:0000030
database_cross_reference: NCIT:C12779
database_cross_reference: SCTID:278197002
database_cross_reference: TAO:0000272
database_cross_reference: UMLS:C0035237
database_cross_reference: VHOG:0000202
database_cross_reference: Wikipedia:Respiratory_system
database_cross_reference: XAO:0000117
database_cross_reference: ZFA:0000272
has exact synonym: apparatus respiratorius
has exact synonym: respiratory system
has_related_synonym: Atmungssystem
has_related_synonym: apparatus respiratorius
has_related_synonym: systema respiratorium
id: UBERON:0001004
in_subset: efo slim
in_subset: functional classification
in_subset: human reference atlas
in_subset: human subset
in_subset: mouse subset
in_subset: pheno slim
in_subset: uberon slim
in_subset: vertebrate core

Axiom
annotated source: respiratory system
annotated property: definition
annotated target: Functional system which consists of structures involved in respiration.
database_cross_reference: Wikipedia:Respiratory_system
database_cross_reference: http://orcid.org/0000-0002-6601-2165

Axiom
annotated source: respiratory system
annotated property: never in taxon
annotated target: NCBITaxon_147099
source: Wikipedia:Acoelomorpha

Axiom
annotated source: respiratory system
annotated property: external_definition
annotated target: The anatomical system in which the exchange of oxygen and carbon dioxide between the organism and its environment.[AAO]
date retrieved: 2012-06-20
external class: AAO:0000541
ontology: AAO
source: AAO:BJB

Axiom
annotated source: respiratory system
annotated property: homology_notes
annotated target: There is no doubt that the primitive pattern of vertebrate air-breathing is the buccal pulse pump found in actinopterygian fishes.[well established][VHOG]
date retrieved: 2012-09-17
external class: VHOG:0000202
ontology: VHOG
source: ISBN:978-0030223693 Liem KF, Bemis WE, Walker WF, Grande L, Functional Anatomy of the Vertebrates: An Evolutionary Perspective (2001) p.599 and Figure 18-23
source: http://bgee.unil.ch/

Axiom
annotated source: respiratory system
annotated property: database_cross_reference
annotated target: UMLS:C0035237
source: ncithesaurus:Respiratory_System

Axiom
annotated source: respiratory system
annotated property: has_related_synonym
annotated target: Atmungssystem
database_cross_reference: BTO:0000203

Axiom
annotated source: respiratory system
annotated property: has_related_synonym
annotated target: apparatus respiratorius
database_cross_reference: BTO:0000203

Axiom
annotated source: respiratory system
annotated property: has_related_synonym
annotated target: systema respiratorium
database_cross_reference: Wikipedia:Respiratory_system
has synonym type: OMO_0003011

digestive system
type: Class
subclass of: anatomical system
has curation status: External
definition: Anatomical system that has as its parts the organs devoted to the ingestion, digestion, and assimilation of food and the discharge of residual wastes.
present in taxon: NCBITaxon 9606
external_definition: An anatomical system consisting of the alimentary canal and digestive glands responsible for intake, absorption, digestion and excretion of food.[AAO]
has_relational_adjective: digestive
external_ontology_notes: many anatomy ontologies consider gastrointestinal system synonymous with digestive system. here we follow MA in dividing digestive system into gastrointestinal and hepatobiliary. hepatobiliary includes the liver and biliary tract. species-specific AO classes are categorized according to whether liver is included. For example, XAO includes liver as part of XAO:0000125 alimentary system, so we assume this class is the more generic class
database_cross_reference: AAO:0000129
database_cross_reference: BILA:0000082
database_cross_reference: BTO:0000058
database_cross_reference: CALOHA:TS-1293
database_cross_reference: EFO:0000793
database_cross_reference: FBbt:00005055
database_cross_reference: FMA:7152
database_cross_reference: GAID:278
database_cross_reference: MA:0002431
database_cross_reference: MAT:0000018
database_cross_reference: MESH:D004064
database_cross_reference: MIAA:0000018
database_cross_reference: SCTID:278859004
database_cross_reference: TADS:0000170
database_cross_reference: TAO:0000339
database_cross_reference: WBbt:0005748
database_cross_reference: Wikipedia:Digestive_system
database_cross_reference: XAO:0000125
database_cross_reference: ZFA:0000339
database_cross_reference: galen:DigestiveSystem
database_cross_reference: ncithesaurus:Digestive_System
has_related_synonym: alimentary system
has_related_synonym: alimentary tract
has_related_synonym: gastrointestinal system
has_related_synonym: gut
id: UBERON:0001007
in_subset: efo slim
in_subset: human reference atlas
in_subset: human subset
in_subset: mouse subset
in_subset: pheno slim
in_subset: uberon slim
in_subset: vertebrate core

Axiom
annotated source: digestive system
annotated property: definition
annotated target: Anatomical system that has as its parts the organs devoted to the ingestion, digestion, and assimilation of food and the discharge of residual wastes.
database_cross_reference: FB:gg
database_cross_reference: NLM:alimentary+system
database_cross_reference: Wikipedia:Digestive_system

Axiom
annotated source: digestive system
annotated property: external_definition
annotated target: An anatomical system consisting of the alimentary canal and digestive glands responsible for intake, absorption, digestion and excretion of food.[AAO]
date retrieved: 2012-06-20
external class: AAO:0000129
ontology: AAO
source: AAO:BJB

Axiom
annotated source: digestive system
annotated property: external_ontology_notes
annotated target: many anatomy ontologies consider gastrointestinal system synonymous with digestive system. here we follow MA in dividing digestive system into gastrointestinal and hepatobiliary. hepatobiliary includes the liver and biliary tract. species-specific AO classes are categorized according to whether liver is included. For example, XAO includes liver as part of XAO:0000125 alimentary system, so we assume this class is the more generic class
external ontology: MA

Axiom
annotated source: digestive system
annotated property: database_cross_reference
annotated target: FBbt:00005055
mapping justification: ManualMappingCuration

anatomical entity
type: Class
subclass of: object
definition: Biological entity that is either an individual member of a biological species or constitutes the structural organization of an individual member of a biological species.
present in taxon: NCBITaxon_33090
present in taxon: NCBITaxon_33208
present in taxon: NCBITaxon 4751
database_cross_reference: AAO:0010841
database_cross_reference: AEO:0000000
database_cross_reference: BFO:0000004
database_cross_reference: BILA:0000000
database_cross_reference: BIRNLEX:6
database_cross_reference: CARO:0000000
database_cross_reference: EHDAA2:0002229
database_cross_reference: FBbt:10000000
database_cross_reference: FMA:62955
database_cross_reference: HAO:0000000
database_cross_reference: MA:0000001
database_cross_reference: NCIT:C12219
database_cross_reference: TAO:0100000
database_cross_reference: TGMA:0001822
database_cross_reference: UMLS:C1515976
database_cross_reference: WBbt:0000100
database_cross_reference: XAO:0000000
database_cross_reference: ZFA:0100000
id: UBERON:0001062
in_subset: common anatomy
in_subset: human subset
in_subset: mouse subset
in_subset: upper level

Axiom
annotated source: anatomical entity
annotated property: definition
annotated target: Biological entity that is either an individual member of a biological species or constitutes the structural organization of an individual member of a biological species.
database_cross_reference: FMA:62955
database_cross_reference: http://orcid.org/0000-0001-9114-8737

Axiom
annotated source: anatomical entity
annotated property: database_cross_reference
annotated target: FBbt:10000000
mapping justification: ManualMappingCuration

Axiom
annotated source: anatomical entity
annotated property: database_cross_reference
annotated target: UMLS:C1515976
source: ncithesaurus:Anatomic_Structure_System_or_Substance

caudate nucleus
type: Class
subclass of: telencephalic nucleus
has curation status: External
definition: Subcortical nucleus of telecephalic origin consisting of an elongated gray mass lying lateral to and bordering the lateral ventricle. It is divided into a head, body and tail in some species.
present in taxon: NCBITaxon 9606
external_definition: Nucleus of brain which is an elongated crescent-shaped mass lying parallel and adjacent to the lateral ventricle throughout its extent[FMA:61833].
has_alternative_id: UBERON:0010122
database_cross_reference: BAMS:CA
database_cross_reference: BAMS:Cd
database_cross_reference: BIRNLEX:1373
database_cross_reference: BM:Tel-CA
database_cross_reference: BTO:0000211
database_cross_reference: CALOHA:TS-0121
database_cross_reference: DHBA:10334
database_cross_reference: DMBA:15855
database_cross_reference: EFO:0000907
database_cross_reference: EHDAA2:0004461
database_cross_reference: EMAPA:18207
database_cross_reference: EV:0100185
database_cross_reference: FMA:61833
database_cross_reference: GAID:670
database_cross_reference: HBA:4278
database_cross_reference: MA:0000894
database_cross_reference: MAT:0000513
database_cross_reference: MESH:D002421
database_cross_reference: NCIT:C12451
database_cross_reference: PBA:10082
database_cross_reference: SCTID:279297002
database_cross_reference: UMLS:C0007461
database_cross_reference: Wikipedia:Caudate_nucleus
database_cross_reference: neuronames:226
has exact synonym: caudatus
has_related_synonym: Ammon horn fields
has_related_synonym: caudatum
has_related_synonym: nucleus caudatus
id: UBERON:0001873
in_subset: efo slim
in_subset: human reference atlas
in_subset: human subset
in_subset: mouse subset
in_subset: pheno slim
in_subset: uberon slim

Axiom
annotated source: caudate nucleus
annotated property: definition
annotated target: Subcortical nucleus of telecephalic origin consisting of an elongated gray mass lying lateral to and bordering the lateral ventricle. It is divided into a head, body and tail in some species.
database_cross_reference: BIRNLEX:1373

Axiom
annotated source: caudate nucleus
annotated property: external_definition
annotated target: Nucleus of brain which is an elongated crescent-shaped mass lying parallel and adjacent to the lateral ventricle throughout its extent[FMA:61833].
source: FMA:61833

Axiom
annotated source: caudate nucleus
annotated property: database_cross_reference
annotated target: UMLS:C0007461
source: BIRNLEX:1373
source: ncithesaurus:Caudate_Nucleus

Axiom
annotated source: caudate nucleus
annotated property: database_cross_reference
annotated target: neuronames:226
source: BIRNLEX:1373

Axiom
annotated source: caudate nucleus
annotated property: has_related_synonym
annotated target: Ammon horn fields
database_cross_reference: BAMS:CA

Axiom
annotated source: caudate nucleus
annotated property: has_related_synonym
annotated target: caudatum
database_cross_reference: BTO:0000211

Axiom
annotated source: caudate nucleus
annotated property: has_related_synonym
annotated target: nucleus caudatus
database_cross_reference: BTO:0000211
database_cross_reference: Wikipedia:Caudate_nucleus
has synonym type: OMO_0003011

nucleus of brain
type: Class
subclass of: neural nucleus
definition: A neural nucleus that is part of the brain.
database_cross_reference: EMAPA:35185
database_cross_reference: FMA:83840
database_cross_reference: MA:0000811
database_cross_reference: NCIT:C49346
database_cross_reference: SCTID:426465002
database_cross_reference: UMLS:C1706993
database_cross_reference: ZFA:0005575
has exact synonym: brain nucleus
has_related_synonym: brain nuclei
id: UBERON:0002308
in_subset: human subset
in_subset: mouse subset

Axiom
annotated source: nucleus of brain
annotated property: definition
annotated target: A neural nucleus that is part of the brain.
database_cross_reference: http://orcid.org/0000-0002-6601-2165

Axiom
annotated source: nucleus of brain
annotated property: database_cross_reference
annotated target: UMLS:C1706993
source: ncithesaurus:Brain_Nucleus

Axiom
annotated source: nucleus of brain
annotated property: has_related_synonym
annotated target: brain nuclei
database_cross_reference: ZFA:0005575
has synonym type: OMO_0003004

cardiovascular system
type: Class
subclass of: anatomical system
subclass of: structure with developmental contribution from neural crest
has curation status: External
definition: Anatomical system that has as its parts the heart and blood vessels.
curator note: we treat cardiovascular as part of circulatory system, with the latter including other kinds of circulation, including lymph.
present in taxon: NCBITaxon 9606
homology_notes: The vessels of the cardiovascular system are as varied as the diverse organs they supply. However, these variations are based on modifications of a fundamental plan of organization common to vertebrates.[well established][VHOG]
database_cross_reference: AAO:0011001
database_cross_reference: BILA:0000016
database_cross_reference: BTO:0000088
database_cross_reference: CALOHA:TS-1297
database_cross_reference: EFO:0000791
database_cross_reference: EHDAA:394
database_cross_reference: EMAPA:16104
database_cross_reference: EV:0100017
database_cross_reference: FMA:7161
database_cross_reference: GAID:467
database_cross_reference: MA:0000010
database_cross_reference: MAT:0000016
database_cross_reference: MESH:D002319
database_cross_reference: MIAA:0000016
database_cross_reference: NCIT:C12686
database_cross_reference: SCTID:278198007
database_cross_reference: TAO:0000010
database_cross_reference: UMLS:C0007226
database_cross_reference: VHOG:0000302
database_cross_reference: WikipediaCategory:Cardiovascular_system
database_cross_reference: XAO:0000100
database_cross_reference: XAO:0001010
database_cross_reference: ZFA:0000010
has_related_synonym: CV system
has_related_synonym: Herz und Gefaesssystem
id: UBERON:0004535
in_subset: efo slim
in_subset: human reference atlas
in_subset: human subset
in_subset: mouse subset
in_subset: pheno slim
in_subset: uberon slim
in_subset: vertebrate core

Axiom
annotated source: cardiovascular system
annotated property: definition
annotated target: Anatomical system that has as its parts the heart and blood vessels.
database_cross_reference: BTO:0000088

Axiom
annotated source: cardiovascular system
annotated property: homology_notes
annotated target: The vessels of the cardiovascular system are as varied as the diverse organs they supply. However, these variations are based on modifications of a fundamental plan of organization common to vertebrates.[well established][VHOG]
date retrieved: 2012-09-17
external class: VHOG:0000302
ontology: VHOG
source: ISBN:978-0072528305 Kardong KV, Vertebrates: Comparative Anatomy, Function, Evolution (2006) p.451
source: http://bgee.unil.ch/

Axiom
annotated source: cardiovascular system
annotated property: database_cross_reference
annotated target: UMLS:C0007226
source: ncithesaurus:Cardiovascular_System

Axiom
annotated source: cardiovascular system
annotated property: has_related_synonym
annotated target: CV system
database_cross_reference: BTO:0000088

Axiom
annotated source: cardiovascular system
annotated property: has_related_synonym
annotated target: Herz und Gefaesssystem
database_cross_reference: BTO:0000088

multi cell part structure
type: Class
subclass of: anatomical structure
definition: A structure consisting mainly of cell components, rather than complete cells.
external_ontology_notes: we go with the FMA classification rather than the CARO one. FMA def: 'Anatomical cluster which has as direct parts cell parts from two or more cells.'
database_cross_reference: AAO:0011000
database_cross_reference: CARO:0001000
database_cross_reference: FBbt:00007060
database_cross_reference: FMA:83115
has exact synonym: multi-cell-component structure
has exact synonym: multi-cell-part structure
has_related_synonym: cell part cluster
id: UBERON:0005162
in_subset: human subset
in_subset: mouse subset
in_subset: upper level
comment: Such a structure may contain some complete cells in addition to partial cells (e.g., glia in nervous system regions).

Axiom
annotated source: multi cell part structure
annotated property: definition
annotated target: A structure consisting mainly of cell components, rather than complete cells.
database_cross_reference: CARO:0001000

Axiom
annotated source: multi cell part structure
annotated property: external_ontology_notes
annotated target: we go with the FMA classification rather than the CARO one. FMA def: 'Anatomical cluster which has as direct parts cell parts from two or more cells.'
external ontology: CARO
external ontology: FMA

Axiom
annotated source: multi cell part structure
annotated property: database_cross_reference
annotated target: FBbt:00007060
mapping justification: ManualMappingCuration

Axiom
annotated source: multi cell part structure
annotated property: has exact synonym
annotated target: multi-cell-component structure
database_cross_reference: CARO:0001000

Axiom
annotated source: multi cell part structure
annotated property: has exact synonym
annotated target: multi-cell-part structure
database_cross_reference: CARO:0001000

Axiom
annotated source: multi cell part structure
annotated property: has_related_synonym
annotated target: cell part cluster
database_cross_reference: FMA:83115

bodily fluid
type: Class
subclass of: organism substance
has curation status: External
definition: Liquid components of living organisms. includes fluids that are excreted or secreted from the body as well as body water that normally is not.
has_broad_synonym: fluid
database_cross_reference: BIRNLEX:20
database_cross_reference: EMAPA:37441
database_cross_reference: FMA:280556
database_cross_reference: GAID:266
database_cross_reference: MESH:D001826
database_cross_reference: Wikipedia:Body_fluid
database_cross_reference: galen:BodyFluid
has exact synonym: body fluid
id: UBERON:0006314
in_subset: human subset
in_subset: mouse subset
in_subset: pheno slim

Axiom
annotated source: bodily fluid
annotated property: definition
annotated target: Liquid components of living organisms. includes fluids that are excreted or secreted from the body as well as body water that normally is not.
database_cross_reference: MESH:A12.207
database_cross_reference: Wikipedia:Body_fluid

Axiom
annotated source: bodily fluid
annotated property: database_cross_reference
annotated target: EMAPA:37441
source: MA:th

Axiom
annotated source: bodily fluid
annotated property: has exact synonym
annotated target: body fluid
database_cross_reference: GAID:266

telencephalic nucleus
type: Class
subclass of: nucleus of brain
definition: A nucleus of brain that is part of a telencephalon.
database_cross_reference: TAO:0002178
database_cross_reference: ZFA:0001660
id: UBERON:0009663
in_subset: human subset
in_subset: mouse subset

Axiom
annotated source: telencephalic nucleus
annotated property: definition
annotated target: A nucleus of brain that is part of a telencephalon.
database_cross_reference: OBOL:automatic

multicellular anatomical structure
type: Class
subclass of: anatomical structure
definition: An anatomical structure that has more than one cell as a part.
present in taxon: NCBITaxon_33090
present in taxon: NCBITaxon_33208
present in taxon: NCBITaxon 4751
database_cross_reference: CARO:0010000
database_cross_reference: FBbt:00100313
has exact synonym: multicellular structure
id: UBERON:0010000
in_subset: common anatomy
in_subset: human subset
in_subset: mouse subset
in_subset: upper level

Axiom
annotated source: multicellular anatomical structure
annotated property: definition
annotated target: An anatomical structure that has more than one cell as a part.
database_cross_reference: CARO:0010000

Axiom
annotated source: multicellular anatomical structure
annotated property: database_cross_reference
annotated target: FBbt:00100313
mapping justification: ManualMappingCuration

Axiom
annotated source: multicellular anatomical structure
annotated property: has exact synonym
annotated target: multicellular structure
database_cross_reference: FBbt:00100313

structure with developmental contribution from neural crest
type: Class
subclass of: anatomical structure
definition: An anatomical structure that has some part that develops from the neural crest.
curator note: Grouping term for query purposes
id: UBERON:0010314
in_subset: grouping class
in_subset: human subset
in_subset: mouse subset

Axiom
annotated source: structure with developmental contribution from neural crest
annotated property: definition
annotated target: An anatomical structure that has some part that develops from the neural crest.
database_cross_reference: https://orcid.org/0000-0002-6601-2165

central nervous system cell part cluster
type: Class
subclass of: multi cell part structure
definition: A multi cell part structure that is part of a central nervous system.
database_cross_reference: FMA:83143
has exact synonym: cell part cluster of neuraxis
has exact synonym: neuraxis layer
id: UBERON:0011215
in_subset: human subset
in_subset: mouse subset
in_subset: upper level

Axiom
annotated source: central nervous system cell part cluster
annotated property: definition
annotated target: A multi cell part structure that is part of a central nervous system.
database_cross_reference: OBOL:automatic

Axiom
annotated source: central nervous system cell part cluster
annotated property: has exact synonym
annotated target: cell part cluster of neuraxis
database_cross_reference: FMA:83143

Axiom
annotated source: central nervous system cell part cluster
annotated property: has exact synonym
annotated target: neuraxis layer
database_cross_reference: FMA:83143

life cycle temporal boundary
type: Class
subclass of: processual entity
definition: A temporal boundary connecting two life cycle stages that follow in immediate succession. A temporal boundary is an abstract, instantaneous entity.
present in taxon: NCBITaxon_33090
present in taxon: NCBITaxon_33208
present in taxon: NCBITaxon 4751
id: UBERON:0035943
in_subset: common anatomy
in_subset: human subset
in_subset: mouse subset
in_subset: upper level

Axiom
annotated source: life cycle temporal boundary
annotated property: definition
annotated target: A temporal boundary connecting two life cycle stages that follow in immediate succession. A temporal boundary is an abstract, instantaneous entity.
database_cross_reference: https://orcid.org/0000-0002-6601-2165