---
name: manuscript-studio
description: Draft and revise research manuscripts, cover letters, and point-by-point responses to reviewers for Bowen Li's mRNA/LNP lab. Use for writing/editing paper sections, formatting for Nature/Cell Press/ACS/Molecular Therapy, building rebuttal letters, cover letters, and reporting summaries. Triggers on "manuscript", "revision", "response to reviewers", "rebuttal", "cover letter", "submit to Nature/Cell/ACS".
---

# Manuscript Studio — Paper Writing & Revision

Help Bowen Li (PI, mRNA/LNP delivery lab, UofT Pharmacy) draft and revise manuscripts for high-impact venues (Nature Nanotechnology, Nature Communications, Nature Biotechnology, Cell Press, ACS Nano, Molecular Therapy).

## Workflow
1. **Find the artifacts.** Manuscript drafts, SI, figures, and reviewer comments live in `~/Desktop/10_Research_Manuscripts/` and `~/Downloads/10_Research_Manuscripts/`. Read the current draft + reviewer comments before writing.
2. **Match the venue.** Confirm target journal → apply its structure (abstract length, main-text word limit, figure count, reference style, reporting summary requirements).
3. **Response-to-reviewers:** produce a point-by-point rebuttal. For each comment: quote it, state the change, quote the new manuscript text, and cite new data. Group by reviewer. Be gracious, specific, and evidence-first. Distinguish changes made vs. respectfully rebutted.
4. **Cover letters:** 1 page — significance, novelty, fit for the journal's readership, non-overlap with concurrent submissions, suggested/excluded reviewers.
5. **Consistency pass:** terminology (ionizable lipid vs cationic; LNP vs nanoparticle), gene/protein nomenclature (italic genes), figure callouts in order, abbreviations defined once.

## Domain vocabulary to keep straight
Ionizable lipid, apparent pKa, LNP, mRNA/self-amplifying RNA, N/P ratio, endosomal escape, ApoE corona, barcoded LNP screening, CAR-T, CRISPR RNP vs mRNA, bnAb, mucosal immunity.

## Style
- Precise, restrained, hypothesis-led. No inflated claims ("revolutionary", "unprecedented") — journals and reviewers dislike them. Run the `humanizer` skill on final prose to strip AI tells.
- Preserve Bowen's established phrasing from prior published papers where available.

## Deliverables
Output as `.docx` (docx skill) with tracked structure, or a clean rebuttal document. Always end with a submission checklist (main text, SI, reporting summary, cover letter, author contributions, data availability).