aid: 1gene
name: 1GENE
description: >-
  1GENE (壹基因) is the brand of Hangzhou He-Yi Gene Technology Co., Ltd., a Chinese
  molecular-diagnostics company founded in Hangzhou's Binjiang district in May 2014 by
  chairman and chief executive Junyi Wang. It develops non-invasive early cancer screening
  tests built on proprietary tumour DNA methylation markers and liquid- and stool-based
  biopsy chemistry, sold under the mission of "letting everyone stay away from cancer
  earlier". Its product pipeline covers colorectal cancer screening (常壹宁), gastric
  pathogen screening and medication guidance (优壹宁), gastric cancer screening (卫壹宁),
  and liver and oesophageal cancer screening in development; company scientists co-authored
  a validated stool-DNA biomarker panel for colorectal neoplasms in the Journal of Cancer
  Research and Clinical Oncology. The company raised an angel round in 2014, a RMB 49.5M
  Series A in 2015 and a Series B of several tens of millions of RMB from listed
  pharmaceutical maker Chengda Pharmaceuticals in December 2022, and its shares are listed
  for secondary-market trading on EquityZen. 1GENE sells a clinical test, not software: it
  publishes no developer program, no public API, no SDK and no machine-readable
  specification, and as of this profile its own web origin at www.1gene.com.cn is
  unconfigured and serves a placeholder page.
url: https://raw.githubusercontent.com/api-evangelist/1gene/refs/heads/main/apis.yml
x-harvest-source-url: https://equityzen.com/company/1gene
x-type: company
x-source: harvest:secondary-market
x-tier: stub
x-tier-reason: no-api-surface
x-legal-name: 杭州和壹基因科技有限公司 (Hangzhou He-Yi Gene Technology Co., Ltd.)
x-founded: '2014-05'
x-headquarters: Binjiang District, Hangzhou, Zhejiang, China
x-domain-status: origin-not-configured
x-domain-note: >-
  The company's registrable domain 1gene.com.cn is still registered through Alibaba Cloud
  (created 2014-04-06, expires 2027-04-06, status ok) and still carries live NetEase MX and
  SPF records, so the domain is held by the company group. The web origin behind it is not
  configured: www.1gene.com.cn answers HTTP 200 with the stock Nginx Proxy Manager "Default
  Site" placeholder (Last-Modified 2026-06-03), HTTPS on that host aborts the TLS handshake
  with unrecognized_name, and the apex plus the m./admin. subdomains do not answer at all.
  Every /.well-known/ and contract-discovery path on the reachable host returns a real 404.
  Because a placeholder is not a web presence, no type Website pointer is wired — the same
  posture applied to other harvest records with dead origins (roadmap#56). The EquityZen
  page that surfaced this company is a trading venue and is recorded as x-harvest-source-url,
  never as a Website. See well-known/1gene-well-known.yml for the full probe record.
deliveryModel:
  model: unknown
  open_source: false
  commercial: true
  callable_host: false
  label: Clinical diagnostics service — no callable API surface on record
  confidence: medium
  source:
  - well-known/1gene-well-known.yml
  generated: '2026-09-05'
  method: derived
specificationVersion: '0.23'
created: '2026-09-05'
modified: '2026-09-05'
tags:
- Company
- Health
- Healthcare
- Biotechnology
- Genomics
- Diagnostics
- Cancer Screening
- Precision Medicine
- Life Sciences
- China
tags_raw:
- Company
- Health
- Healthcare
- Biotechnology
- Genomics
- Diagnostics
- Cancer Screening
- Precision Medicine
- Life Sciences
- China
apis: []
maintainers:
- FN: Kin Lane
  email: kin@apievangelist.com
- FN: APIs.json
  email: info@apis.io
common:
- type: DomainSecurity
  url: security/1gene-domain-security.yml
x-coverage:
  state: none
  reason: no-developer-program
  detail: >-
    1GENE sells non-invasive cancer early-screening lab tests to consumers and clinics and
    publishes no developer program in either Chinese- or English-language sources; its own
    www.1gene.com.cn now answers HTTP 200 with an unconfigured Nginx Proxy Manager "Default
    Site" placeholder and every /.well-known/ and spec path on it returns a real 404, with
    no api./open./developer./docs. subdomain resolving and no GitHub organization or
    published package anywhere.
  evidence:
  - url: http://www.1gene.com.cn/
    status: 200
  - url: http://www.1gene.com.cn/openapi.json
    status: 404
  - url: http://www.1gene.com.cn/.well-known/agent-card.json
    status: 404
  - url: http://www.1gene.com.cn/llms.txt
    status: 404
  - url: https://api.github.com/orgs/1gene
    status: 404
  - url: https://pypi.org/pypi/1gene/json
    status: 404
  checked: '2026-09-05'
x-enrichment:
  date: '2026-09-05'
  status: minimal
  artifacts_added: 2
  pass: local-v3