openapi: 3.2.0
info:
  title: 2s — the (most) everything Bio API
  version: '1'
  summary: The (most) everything API.
  description: 'The (most) everything API for AI agents: 575+ pay-per-call endpoints on one origin.'
  contact:
    name: 2s
    url: https://2s.io
    email: alley@2s.io
  x-logo:
    url: https://2s.io/icon-512.png
    altText: 2s
  x-guidance: 'Pay-per-call REST API for AI agents — hundreds of endpoints returning ground-truth data (US public records, company & legal identifiers, finance/SEC, crypto/web3, security & CVEs, medical codes, weather & geocoding, agriculture, energy, maritime, music, and more). Every endpoint is paid per call in USDC via x402 (Base or Solana) — no API key, no signup. Call any endpoint with no auth to get a 402 PaymentRequirements envelope, sign it (EIP-3009 on Base, partial SPL transfer on Solana), and retry with the PAYMENT-SIGNATURE header. Add ?trial=1 for one free real call per endpoint per hour to test before paying. To discover the right endpoint: GET https://2s.io/api/directory for the full catalog, or GET https://2s.io/api/search/endpoints?q=<natural-language task> for a ranked match. Per-call price is on each operation as x-payment-info (from $0.001). Batch up to 50 calls behind one payment via POST https://2s.io/api/batch/run.'
servers:
- url: https://2s.io
tags:
- name: bio
paths:
  /api/bio/gene:
    get:
      tags:
      - bio
      summary: Look up a gene by its official symbol (e.g
      description: 'Look up a gene by its official symbol (e.g. "TP53", "BRCA1", "CFTR") and organism (taxid, default 9606 = human), merging NCBI Gene with UniProt. Returns the gene symbol, NCBI Gene ID, full description, organism, chromosome + cytogenetic map location, alias symbols, and the curated RefSeq function summary; plus the reviewed protein from UniProt — accession, entry id, recommended protein name, length in amino acids, and the curated function description. NCBI + UniProt links. Bioinformatics, clinical-genetics research, education. Public-domain NCBI + CC-BY UniProt data. Common organism taxids: human 9606, mouse 10090, zebrafish 7955, fruit fly 7227, yeast 559292.'
      operationId: bio_gene
      deprecated: false
      security:
      - x402Payment: []
      responses:
        '200':
          description: 'Normalized envelope: items = [{ gene }] (one gene; the best-effort UniProt protein sub-block stays inside the item); total = 1; meta.sources lists both NCBI Gene + UniProt attributions (envelope source is the primary, NCBI Gene).'
          content:
            application/json:
              schema:
                type: object
                required:
                - data
                - meta
                properties:
                  data:
                    type: object
                    properties:
                      ok:
                        type: boolean
                        enum:
                        - true
                      items:
                        type: array
                        items:
                          type: object
                          properties:
                            gene:
                              type: object
                              properties:
                                symbol:
                                  type: string
                                  nullable: true
                                ncbiGeneId:
                                  type: string
                                  nullable: true
                                description:
                                  type: string
                                  nullable: true
                                organism:
                                  type: object
                                  properties:
                                    scientificName:
                                      type: string
                                      nullable: true
                                    commonName:
                                      type: string
                                      nullable: true
                                    taxid:
                                      type: number
                                      nullable: true
                                  required:
                                  - scientificName
                                  - commonName
                                  - taxid
                                  additionalProperties: false
                                  nullable: true
                                chromosome:
                                  type: string
                                  nullable: true
                                mapLocation:
                                  type: string
                                  nullable: true
                                aliases:
                                  type: array
                                  items:
                                    type: string
                                summary:
                                  type: string
                                  nullable: true
                                protein:
                                  type: object
                                  properties:
                                    found:
                                      type: boolean
                                    uniprotAccession:
                                      type: string
                                      nullable: true
                                    uniprotId:
                                      type: string
                                      nullable: true
                                    name:
                                      type: string
                                      nullable: true
                                    lengthAa:
                                      type: number
                                      nullable: true
                                    function:
                                      type: string
                                      nullable: true
                                  required:
                                  - found
                                  - uniprotAccession
                                  - uniprotId
                                  - name
                                  - lengthAa
                                  - function
                                  additionalProperties: false
                                ncbiUrl:
                                  type: string
                                  nullable: true
                                uniprotUrl:
                                  type: string
                                  nullable: true
                              required:
                              - symbol
                              - ncbiGeneId
                              - description
                              - organism
                              - chromosome
                              - mapLocation
                              - aliases
                              - summary
                              - protein
                              - ncbiUrl
                              - uniprotUrl
                              additionalProperties: false
                          required:
                          - gene
                          additionalProperties: false
                      total:
                        type: integer
                        nullable: true
                        description: Total matching rows upstream; null when unknown.
                      source:
                        $ref: '#/components/schemas/Source'
                      meta:
                        type: object
                        properties:
                          sources:
                            type: array
                            items:
                              $ref: '#/components/schemas/Source'
                        required:
                        - sources
                        additionalProperties: false
                    required:
                    - ok
                    - items
                    - total
                    - source
                    additionalProperties: false
                  meta:
                    $ref: '#/components/schemas/CallMeta'
        '400':
          $ref: '#/components/responses/BadRequest'
        '402':
          $ref: '#/components/responses/PaymentRequired'
        '405':
          $ref: '#/components/responses/MethodNotAllowed'
        '500':
          $ref: '#/components/responses/ServerError'
        '502':
          $ref: '#/components/responses/UpstreamError'
      x-2s-id: bio.gene
      x-2s-version: null
      x-2s-price:
        usd: 0.0048
      x-2s-accepts:
      - x402
      x-2s-response-shape: normalized
      x-payment-info:
        price:
          mode: fixed
          currency: USD
          amount: '0.004800'
        protocols:
        - x402: {}
      parameters:
      - name: symbol
        in: query
        required: true
        description: Symbol.
        schema:
          type: string
          minLength: 1
          maxLength: 30
      - name: taxid
        in: query
        required: false
        description: Taxid.
        schema:
          type: integer
          minimum: 1
          maximum: 9999999
          default: 9606
      - $ref: '#/components/parameters/TrialMode'
  /api/bio/protein:
    get:
      tags:
      - bio
      summary: Look up a protein in UniProtKB by accession (e.g
      description: 'Look up a protein in UniProtKB by accession (e.g. "P04637", "Q9Y6K9", "P0DTC2"). Returns the entry id, reviewed (Swiss-Prot) flag, recommended + alternative protein names, gene names, organism + taxid, sequence length and molecular weight, the curated function description, subcellular locations, Gene Ontology terms (id + term + aspect: biological_process / molecular_function / cellular_component), PDB structure ids, and keywords. Bioinformatics, structural biology, drug-target research, education. Gene-centric sibling: /api/bio/gene. CC-BY UniProt data.'
      operationId: bio_protein
      deprecated: false
      security:
      - x402Payment: []
      responses:
        '200':
          description: 'Normalized envelope: items = [{ protein }] (one UniProtKB entry: names, organism, sequence, function, GO terms, PDB ids); total = 1.'
          content:
            application/json:
              schema:
                type: object
                required:
                - data
                - meta
                properties:
                  data:
                    type: object
                    properties:
                      ok:
                        type: boolean
                        enum:
                        - true
                      items:
                        type: array
                        items:
                          type: object
                          properties:
                            protein:
                              type: object
                              properties:
                                accession:
                                  type: string
                                entryId:
                                  type: string
                                  nullable: true
                                reviewed:
                                  type: boolean
                                proteinName:
                                  type: string
                                  nullable: true
                                alternativeNames:
                                  type: array
                                  items:
                                    type: string
                                genes:
                                  type: array
                                  items:
                                    type: string
                                organism:
                                  type: object
                                  properties:
                                    scientificName:
                                      type: string
                                      nullable: true
                                    commonName:
                                      type: string
                                      nullable: true
                                    taxid:
                                      type: number
                                      nullable: true
                                  required:
                                  - scientificName
                                  - commonName
                                  - taxid
                                  additionalProperties: false
                                  nullable: true
                                lengthAa:
                                  type: number
                                  nullable: true
                                molecularWeightDa:
                                  type: number
                                  nullable: true
                                function:
                                  type: string
                                  nullable: true
                                subcellularLocations:
                                  type: array
                                  items:
                                    type: string
                                goTerms:
                                  type: array
                                  items:
                                    type: object
                                    properties:
                                      id:
                                        type: string
                                      term:
                                        type: string
                                      aspect:
                                        type: string
                                        nullable: true
                                    required:
                                    - id
                                    - term
                                    - aspect
                                    additionalProperties: false
                                pdbStructures:
                                  type: array
                                  items:
                                    type: string
                                keywords:
                                  type: array
                                  items:
                                    type: string
                                uniprotUrl:
                                  type: string
                              required:
                              - accession
                              - entryId
                              - reviewed
                              - proteinName
                              - alternativeNames
                              - genes
                              - organism
                              - lengthAa
                              - molecularWeightDa
                              - function
                              - subcellularLocations
                              - goTerms
                              - pdbStructures
                              - keywords
                              - uniprotUrl
                              additionalProperties: false
                          required:
                          - protein
                          additionalProperties: false
                      total:
                        type: integer
                        nullable: true
                        description: Total matching rows upstream; null when unknown.
                      source:
                        $ref: '#/components/schemas/Source'
                    required:
                    - ok
                    - items
                    - total
                    - source
                    additionalProperties: false
                  meta:
                    $ref: '#/components/schemas/CallMeta'
        '400':
          $ref: '#/components/responses/BadRequest'
        '402':
          $ref: '#/components/responses/PaymentRequired'
        '405':
          $ref: '#/components/responses/MethodNotAllowed'
        '500':
          $ref: '#/components/responses/ServerError'
        '502':
          $ref: '#/components/responses/UpstreamError'
      x-2s-id: bio.protein
      x-2s-version: null
      x-2s-price:
        usd: 0.0036
      x-2s-accepts:
      - x402
      x-2s-response-shape: normalized
      x-payment-info:
        price:
          mode: fixed
          currency: USD
          amount: '0.003600'
        protocols:
        - x402: {}
      parameters:
      - name: accession
        in: query
        required: true
        description: Accession.
        schema:
          type: string
          minLength: 2
          maxLength: 20
          pattern: ^[A-Za-z0-9]+$
      - $ref: '#/components/parameters/TrialMode'
  /api/bio/species:
    get:
      tags:
      - bio
      summary: Resolve any organism by scientific or common name to the
      description: Resolve any organism by scientific or common name to the GBIF taxonomic backbone — the canonical free reference for life on Earth. Returns the accepted scientific name + canonical name, taxonomic rank and status, the match type/confidence, the full classification (kingdom → phylum → class → order → family → genus → species), up to 8 English vernacular (common) names, the count of recorded occurrences worldwide, and the GBIF species URL. Biodiversity, ecology, education, and as a taxonomy normalizer for other pipelines. Fuzzy-matches misspellings. CC-BY GBIF data.
      operationId: bio_species
      deprecated: false
      security:
      - x402Payment: []
      responses:
        '200':
          description: 'Normalized envelope: items = [{ species }] (one resolved taxon; classification + vernacular + occurrence sub-blocks stay inside the item, best-effort); total = 1.'
          content:
            application/json:
              schema:
                type: object
                required:
                - data
                - meta
                properties:
                  data:
                    type: object
                    properties:
                      ok:
                        type: boolean
                        enum:
                        - true
                      items:
                        type: array
                        items:
                          type: object
                          properties:
                            species:
                              type: object
                              properties:
                                usageKey:
                                  type: number
                                  nullable: true
                                scientificName:
                                  type: string
                                  nullable: true
                                canonicalName:
                                  type: string
                                  nullable: true
                                rank:
                                  type: string
                                  nullable: true
                                taxonomicStatus:
                                  type: string
                                  nullable: true
                                matchType:
                                  type: string
                                  nullable: true
                                matchConfidence:
                                  type: number
                                  nullable: true
                                classification:
                                  type: object
                                  properties:
                                    kingdom:
                                      type: string
                                      nullable: true
                                    phylum:
                                      type: string
                                      nullable: true
                                    class:
                                      type: string
                                      nullable: true
                                    order:
                                      type: string
                                      nullable: true
                                    family:
                                      type: string
                                      nullable: true
                                    genus:
                                      type: string
                                      nullable: true
                                    species:
                                      type: string
                                      nullable: true
                                  required:
                                  - kingdom
                                  - phylum
                                  - class
                                  - order
                                  - family
                                  - genus
                                  - species
                                  additionalProperties: false
                                vernacularNames:
                                  type: array
                                  items:
                                    type: string
                                occurrenceCount:
                                  type: number
                                  nullable: true
                                gbifUrl:
                                  type: string
                                  nullable: true
                              required:
                              - usageKey
                              - scientificName
                              - canonicalName
                              - rank
                              - taxonomicStatus
                              - matchType
                              - matchConfidence
                              - classification
                              - vernacularNames
                              - occurrenceCount
                              - gbifUrl
                              additionalProperties: false
                          required:
                          - species
                          additionalProperties: false
                      total:
                        type: integer
                        nullable: true
                        description: Total matching rows upstream; null when unknown.
                      source:
                        $ref: '#/components/schemas/Source'
                    required:
                    - ok
                    - items
                    - total
                    - source
                    additionalProperties: false
                  meta:
                    $ref: '#/components/schemas/CallMeta'
        '400':
          $ref: '#/components/responses/BadRequest'
        '402':
          $ref: '#/components/responses/PaymentRequired'
        '405':
          $ref: '#/components/responses/MethodNotAllowed'
        '500':
          $ref: '#/components/responses/ServerError'
        '502':
          $ref: '#/components/responses/UpstreamError'
      x-2s-id: bio.species
      x-2s-version: null
      x-2s-price:
        usd: 0.0036
      x-2s-accepts:
      - x402
      x-2s-response-shape: normalized
      x-payment-info:
        price:
          mode: fixed
          currency: USD
          amount: '0.003600'
        protocols:
        - x402: {}
      parameters:
      - name: name
        in: query
        required: true
        description: Name to search for.
        schema:
          type: string
          minLength: 2
          maxLength: 120
      - $ref: '#/components/parameters/TrialMode'
components:
  schemas:
    Source:
      type: object
      description: 'Provenance of the data: upstream provider, source URL, and license.'
      properties:
        provider:
          type: string
          description: Upstream data provider.
        url:
          type: string
          description: Source URL or documentation link.
        license:
          type: string
          description: License / usage terms for the data.
    CallMeta:
      type: object
      description: Per-call meta envelope — endpoint id, cost, caller kind, settlement details.
    X402PaymentRequiredV2:
      type: object
      description: x402 v2 PaymentRequired envelope. Pick any entry from accepts[], sign for that rail, retry with the PAYMENT-SIGNATURE header.
      required:
      - x402Version
      - accepts
      properties:
        x402Version:
          type: integer
          const: 2
        error:
          type: string
          description: Human-readable reason payment is required.
        resource:
          type: string
          description: The resource URL being purchased.
        accepts:
          type: array
          description: Payment requirement options, one per supported network (Base USDC, Solana USDC).
          items:
            type: object
            required:
            - scheme
            - network
            - amount
            - asset
            - payTo
            - maxTimeoutSeconds
            properties:
              scheme:
                type: string
                enum:
                - exact
              network:
                type: string
                description: CAIP-2 network id, e.g. "eip155:8453" (Base) or "solana:5eykt4UsFv8P8NJdTREpY1vzqKqZKvdp".
              amount:
                type: string
                description: Price in atomic asset units (USDC has 6 decimals).
              asset:
                type: string
                description: Asset contract address / mint.
              payTo:
                type: string
                description: Treasury address to pay.
              maxTimeoutSeconds:
                type: integer
              extra:
                type: object
                description: 'Rail-specific extras (EVM: EIP-712 domain name/version; Solana: feePayer).'
                additionalProperties: true
        extensions:
          type: object
          description: Optional discovery metadata (e.g. bazaar input/output schemas).
          additionalProperties: true
  responses:
    PaymentRequired:
      description: Payment required. Body contains the x402 PaymentRequirements envelope with a multi-network accepts array; the per-call price is in accepts[].amount (and on the operation as x-2s-price). Sign for whichever rail you hold USDC on (EIP-3009 for Base, partial SPL transfer for Solana) and retry with the PAYMENT-SIGNATURE header (X-PAYMENT also accepted for v1 clients).
      content:
        application/json:
          schema:
            $ref: '#/components/schemas/X402PaymentRequiredV2'
    UpstreamError:
      description: Upstream provider error.
    MethodNotAllowed:
      description: Method not allowed — see `Allow` header for the supported method.
    ServerError:
      description: Internal server error.
    BadRequest:
      description: Bad request — invalid parameters.
  parameters:
    TrialMode:
      name: trial
      in: query
      required: false
      description: 'Try before you buy. Set to 1 for one free real call per endpoint per hour — no wallet or payment needed — to verify the endpoint before paying. Equivalent to sending the "X-2s-Trial: 1" request header. Works on every endpoint.'
      schema:
        type: integer
        enum:
        - 1
  securitySchemes:
    x402Payment:
      type: apiKey
      in: header
      name: PAYMENT-SIGNATURE
      description: 'x402 protocol v2: base64-encoded PaymentPayload. Call any paid endpoint without auth to receive a 402 with a multi-network PaymentRequirements envelope. Sign for either rail: EIP-3009 transferWithAuthorization (Base USDC) OR a partial SPL token transfer (Solana USDC). Retry with PAYMENT-SIGNATURE header. X-PAYMENT is also accepted for v1 buyer clients. See https://x402.org.'