# Acelot, Inc.

> Clinical-stage biopharmaceutical company in South San Francisco, California, developing
> first-in-class small-molecule therapies for neurodegenerative disease. Lead candidate ACE-2223
> targets misfolded, aggregated TDP-43 to restore its healthy form and function — pathology central
> to ALS and frontotemporal lobar degeneration (FTLD). Discovery is run on Resolute, Acelot's
> internal AI-driven computational-chemistry drug-discovery platform.

**There is no Acelot API.** Acelot publishes no public API, developer portal, API reference, SDK,
CLI, webhook surface, MCP server, agent card or machine-readable specification. Probed 2026-09-06:
`/openapi.json`, `/openapi.yaml`, `/swagger.json`, `/api-docs`, `/graphql`, `/mcp`, `/llms.txt` and
the RFC 8615 `/.well-known/*` set all returned 404 on both `acelot.com` and `www.acelot.com`. The
Resolute platform is described by the company as employed in-house; it is not offered as a hosted
service or programmable product. If you are an agent looking for an Acelot endpoint to call, there
is not one — contact info@acelot.com instead.

## Company

- [Acelot](https://www.acelot.com/): Company home — programs, platform, team, news.
- [Pipeline & Platform](https://www.acelot.com/pipeline-and-platform): The Resolute discovery
  platform and the neurodegenerative-disease pipeline (TDP-43 positive FTD, Alzheimer's disease,
  inclusion body myositis, multiple system atrophy, dementia with Lewy bodies).
- [ACE-2223](https://www.acelot.com/ace-2223): Lead small-molecule program targeting aggregated
  TDP-43 in ALS and FTLD.
- [Our Team](https://www.acelot.com/our-team): Leadership, scientific and development staff.

## News and science

- [News](https://www.acelot.com/news): Press releases and event appearances.
- [News RSS](https://www.acelot.com/news?format=rss): Machine-readable feed of the news stream.
- [Publications](https://www.acelot.com/publications): Peer-reviewed papers underpinning the
  computational method (J. Chem. Inf. Model. 2011; J. Am. Soc. Mass Spectrom. 2019;
  Biochemistry 2020).

## Code

- [GitHub organization](https://github.com/acelot-inc): Four public repositories, all forks of
  third-party open-source cheminformatics tooling (espsim, kinodata-3D-affinity-prediction, razi,
  smiles-drawer). No first-party library, SDK or service code is published.

## Contact

- info@acelot.com
- 329 Oyster Point Blvd, 3rd Floor, South San Francisco, CA 94080
- [LinkedIn](https://www.linkedin.com/company/acelot-inc./)

## Optional

- This file was generated by API Evangelist from a public, unauthenticated profile of Acelot's own
  website and public GitHub organization. It is a third-party description, not published by Acelot.
  Corrections: https://github.com/api-evangelist/acelot-inc/issues