generated: '2026-09-06' method: searched source: https://api.aclid.bio/openapi.json (tag "Compliance Reason Codes", rendered at https://api.aclid.bio/docs) note: 'Aclid is not a payments provider. This is the non-payments equivalent of a decline-code registry: the published, per-framework code set that explains WHY a screened sequence was flagged and what the customer must do before an order can ship. Codes appear on Finding.reason_code alongside Finding.regulatory_status (controlled | not_controlled); the screen-level outcome is DecisionStatus (awaiting | approved | rejected | escalated). Captured verbatim from the provider''s own OpenAPI tag description — nothing derived or invented.' envelope: code_field: reason_code carried_on: Finding (components.schemas.Finding) companion_fields: - regulatory_status - material decision_field: DecisionStatus on the screen (awaiting | approved | rejected | escalated) framework_count: 8 code_count: 36 frameworks: - id: common_exemptions name: Common Exemption Reason Codes description: This is a set of reason codes common to all frameworks in Aclid's platform that describe exemptions for matching criteria. reason_codes: - code: housekeeping meaning: This gene is specific to a listed bacterium or fungus, but the gene is typically regarded as housekeeping or metabolic. action: This gene is specific to a listed bacterium or fungus, but the gene is typically regarded as housekeeping or metabolic. - code: unspecific meaning: This gene is not specific to a listed agent. action: This gene is not specific to a listed agent. - code: match_window_below_threshold meaning: This gene is below the 16 amino acid or 50 base pair threshold window. action: This gene is below the 16 amino acid or 50 base pair threshold window. - id: us_ccl_export_control name: US Commerce Control List description: The US Commerce Control List is a list of items that are subject to the export control authority of the Department of Commerce's Bureau of Industry and Security (BIS). If you're shipping materials from the US to locations outside the US or non-US persons, you must determine whether the material requires an export license before shipment. reason_codes: - code: toxin meaning: This gene encodes a controlled toxin or subunit. If shipping outside the US or to non-US persons, must file for an export license. action: This gene encodes a controlled toxin or subunit. If shipping outside the US or to non-US persons, must file a classification request or export license. - code: virus meaning: This gene is specific to a controlled virus. If shipping outside the US or to non-US persons, must file for an export license. action: This gene is specific to a controlled virus. A classification request or export license is only required for viral sequences when shipping to states or persons from states that are not participants of Australia Group. - code: pathogenic meaning: This gene is specific to a controlled agent. The gene represents a "significant hazard to human, animal, or plant health" or "could endow or enhance pathogenicity." If shipping outside the US or to non-US persons, must file for an export license. action: This gene is specific to a controlled agent. The gene represents a "significant hazard to human, animal, or plant health" or "could endow or enhance pathogenicity". A classification request or export license is only required for pathogen sequences when shipping to states or persons from states that are not participants of Australia Group. - code: specific meaning: This gene is specific to a controlled bacterium or fungus. The gene is not typically regarded as housekeeping or metabolic. If shipping outside the US or to non-US persons, requires further investigation of function. This sequence may require a classification request from a US export authority. action: This gene is specific to a controlled agent. The gene is not typically regarded as housekeeping or metabolic. This sequence may require a classification request or export license when shipping to states or persons from states that are not participants of Australia Group. - id: eu_dual_use_export_control name: EU Dual-Use Export Control List description: The EU Dual-Use Export Control List is a list of items that are subject to export control under Regulation (EU) 2021/821. If you're shipping materials from the EU to locations outside the EU or non-EU persons, you must determine whether the material requires an export license before shipment. reason_codes: - code: toxin meaning: This gene encodes a controlled toxin or subunit. If shipping outside the EU or to non-EU persons, must file for an export license. action: This gene encodes a controlled toxin or subunit. If shipping outside the EU or to non-EU persons, must file a classification request or export license. - code: virus meaning: This gene is specific to a controlled virus. If shipping outside the EU or to non-EU persons, must file for an export license. action: This gene is specific to a controlled virus. If shipping outside the EU or to non-EU persons, must file a classification request or export license. - code: pathogenic meaning: This gene is specific to a controlled agent. The gene represents a "significant hazard to human, animal, or plant health" or "could endow or enhance pathogenicity". If shipping outside the EU or to non-EU persons, must file for an export license. action: This gene is specific to a controlled agent. The gene represents a "significant hazard to human, animal, or plant health" or "could endow or enhance pathogenicity". If shipping outside the EU or to non-EU persons, must file a classification request or export license. - code: specific meaning: This gene is specific to a controlled bacterium or fungus. The gene is not typically regarded as housekeeping or metabolic. If shipping outside the EU or to non-EU persons, requires further investigation of function. This sequence may require a classification request from an EU export authority. action: This gene is specific to a controlled agent. The gene is not typically regarded as housekeeping or metabolic. If shipping outside the EU or to non-EU persons, requires further investigation of function. This sequence may require a classification request or export license from an EU export authority. - id: us_select_agent name: US Federal Select Agent Program description: The US Federal Select Agent Program oversees the possession, use, and transfer of select agents and toxins, which pose a threat to public, animal, or plant health. If you're shipping materials within the US, you must determine whether the material requires a certificate of registration issued by the US Department of Health and Human Services Secretary and Administrator. reason_codes: - code: toxin meaning: This gene encodes a select toxin or subunit. If shipping to the US or within, recipient must provide a certificate of registration issued by the US Department of Health and Human Services Secretary and Administrator. action: This gene encodes a select toxin or subunit. If shipping to the US or within, recipient must provide a certificate of registration issued by the US Department of Health and Human Services Secretary and Administrator. - code: virus meaning: This gene is derived from a select agent virus. The Federal Select Agent Program only requires registrations for positive strand RNA forms of select agent viral genomes. action: This gene is derived from a select agent virus. The Federal Select Agent Program only requires registrations for positive strand RNA forms of select agent viral genomes. - code: agent meaning: This gene is derived from a select agent bacterium or fungus. The Federal Select Agent Program does not require registrations for nucleic acids derived from select agent bacteria or fungi. action: This gene is derived from a select agent bacterium or fungus. The Federal Select Agent Program does not require registrations for nucleic acids derived from select agent bacteria or fungi. - id: us_screening_framework name: US Screening Framework description: The US Screening Framework is a biosecurity policy that outlines requirements for providers and distributors of synthetic DNA and RNA. If you're shipping materials to researchers or institutions receiving US federal funding, you must comply with the US Screening Framework's requirements for screening sequences of concern (SoCs) and verifying customer legitimacy. reason_codes: - code: toxin meaning: This gene encodes a select or controlled toxin or subunit. The US Department of Health and Human Services identifies this as a "sequence of concern" and recommends follow-up screening. action: This gene encodes a select or controlled toxin or subunit. The US Department of Health and Human Services identifies this as a "sequence of concern" and recommends follow-up screening. - code: virus meaning: This gene is specific to a select, controlled, or warning virus. The US Department of Health and Human Services identifies this as a "sequence of concern" and recommends follow-up screening. action: This gene is specific to a select, controlled, or warning virus. The US Department of Health and Human Services identifies this as a "sequence of concern" and recommends follow-up screening. - code: pathogenic meaning: This gene is derived from a select, controlled, or warning agent. The gene represents a "significant hazard to human, animal, or plant health" or "could endow or enhance pathogenicity". The US Department of Health and Human Services identifies this as a "sequence of concern" and recommends follow-up screening. action: This gene is derived from a select, controlled, or warning agent. The gene represents a "significant hazard to human, animal, or plant health" or "could endow or enhance pathogenicity". The US Department of Health and Human Services identifies this as a "sequence of concern" and recommends follow-up screening. - code: specific meaning: This gene is derived from a select, controlled, or warning agent. The gene is not typically regarded as housekeeping or metabolic. The US Department of Health and Human Services identifies this as a "sequence of concern" and recommends follow-up screening. action: This gene is derived from a select, controlled, or warning agent. The gene is not typically regarded as housekeeping or metabolic. The US Department of Health and Human Services identifies this as a "sequence of concern" and recommends follow-up screening. - id: nih_recombinant_dna_guidelines name: NIH Recombinant DNA Guidelines description: The US National Institutes of Health (NIH) DNA Guidelines are a biosafety best practice and mandatory set of rules that govern safe conduct of research with recombinant DNA at institutions receiving NIH funding. reason_codes: - code: risk_group_1 meaning: Any gene from an agent that is not associated with disease in healthy adult humans. action: This construct is not associated with disease in healthy adult humans and does not require additional considerations or special handling, equipment, or facilities. - code: risk_group_2 meaning: Any gene from an agent that is associated with human disease which is rarely serious and for which preventive therapeutic interventions are often available. action: This construct is associated with Risk Group 2 and may require special handling, equipment, or facilities. Constructs associated with Risk Groups 2-4 should be reviewed according to the NIH Recombinant DNA Guidelines to identify precautionary operating procedures or mitigations. - code: risk_group_3 meaning: Any gene from an agent that is associated with serious or lethal human disease for which preventive or therapeutic interventions may be available (high individual risk but low community risk). action: This construct is associated with Risk Group 3 and may require special handling, equipment, or facilities. Constructs associated with Risk Groups 2-4 should be reviewed according to the NIH Recombinant DNA Guidelines to identify precautionary operating procedures or mitigations. - code: risk_group_4 meaning: Any gene from an agent that is likely to cause serious or lethal human disease for which preventive or therapeutic interventions are not usually available (high individual risk and high community risk). action: This construct is associated with Risk Group 4 and may require special handling, equipment, or facilities. Constructs associated with Risk Groups 2-4 should be reviewed according to the NIH Recombinant DNA Guidelines to identify precautionary operating procedures or mitigations. - id: eu_directive_2000_54_ec name: EU Directive 2000/54/EC description: EU Directive 2000/54/EC is legislation that protects workers from risks related to exposure to biological agents at work. The directive outlines policies that employers in the EU must implement as part of conducting work involving biological hazards including risk assessments, prevention and control, information and training, health surveillance of workers, and notifications to authorities. reason_codes: - code: risk_group_1 meaning: Any gene from an agent that is unlikely to cause human disease. action: This construct is unlikely to cause human disease and does not require additional considerations or special handling, equipment, or facilities. - code: risk_group_2 meaning: Any gene from an agent that can cause human disease and might be a hazard to workers; it is unlikely to spread to the community; there is usually effective prophylaxis or treatment available. action: This construct is associated with Risk Group 2 and may require special handling, equipment, or facilities. Constructs associated with Risk Groups 2-4 should be reviewed according to the NIH Recombinant DNA Guidelines to identify precautionary operating procedures or mitigations. - code: risk_group_3 meaning: Any gene from an agent that can cause severe human disease and present a serious hazard to workers; it may present a risk of spreading to the community, but there is usually effective prophylaxis or treatment available. action: This construct is associated with Risk Group 3 and may require special handling, equipment, or facilities. Constructs associated with Risk Groups 2-4 should be reviewed according to the NIH Recombinant DNA Guidelines to identify precautionary operating procedures or mitigations. - code: risk_group_4 meaning: Any gene from an agent that causes severe human disease and is a serious hazard to workers; it may present a high risk of spreading to the community; there is usually no effective prophylaxis or treatment available. action: This construct is associated with Risk Group 4 and may require special handling, equipment, or facilities. Constructs associated with Risk Groups 2-4 should be reviewed according to the NIH Recombinant DNA Guidelines to identify precautionary operating procedures or mitigations. - id: zkbs_oncogenes name: The Central Committee on Biological Safety (ZKBS) – Oncogenes description: The Central Committee on Biological Safety (ZKBS) is an expert panel established by German law for evaluating risks of genetically modified organisms to humans, animals, and the environment. This is the commission's database for cellular and viral genes / nucleic acids that have been evaluated for oncogenic potential. reason_codes: - code: oncogene meaning: This nucleic acid segment has homology to a known oncogene with neoplastic transforming potential. action: Review this nucleic acid segment's homology to oncogenes, mutations of homologous oncogenes, and ability to silence homologous oncogenes to identify precautionary operating measures or mitigations. - code: shrna_sirna_oncogene meaning: This nucleic acid segment has homology to a known oncogene with neoplastic transforming potential when silenced. action: Review this nucleic acid segment's homology to oncogenes, mutations of homologous oncogenes, and ability to silence homologous oncogenes to identify precautionary operating measures or mitigations. - code: mutant_oncogene meaning: This nucleic acid segment has homology to a known oncogene with neoplastic transforming potential when mutated. action: Review this nucleic acid segment's homology to oncogenes, mutations of homologous oncogenes, and ability to silence homologous oncogenes to identify precautionary operating measures or mitigations. - code: activated_mutant_oncogene meaning: This nucleic acid segment has homology to a known oncogene with neoplastic transforming potential when mutated with increased activity. action: Review this nucleic acid segment's homology to oncogenes, mutations of homologous oncogenes, and ability to silence homologous oncogenes to identify precautionary operating measures or mitigations. - code: deactivated_mutant_oncogene meaning: This nucleic acid segment has homology to a known oncogene with neoplastic transforming potential when mutated with decreased activity. action: Review this nucleic acid segment's homology to oncogenes, mutations of homologous oncogenes, and ability to silence homologous oncogenes to identify precautionary operating measures or mitigations. - code: exon_9_mutated_oncogene meaning: This nucleic acid segment has homology to a known oncogene with neoplastic transforming potential when mutated in the exon-9 region. action: Review this nucleic acid segment's homology to oncogenes, mutations of homologous oncogenes, and ability to silence homologous oncogenes to identify precautionary operating measures or mitigations. - id: usda_vs name: USDA APHIS VS-Regulated Livestock and Poultry Pathogens description: The USDA APHIS Veterinary Services (VS) regulates the importation and interstate transport of livestock and poultry pathogens. Researchers and importers must apply for Organisms and Vectors (OV) permits to handle these biological materials. USDA Veterinary Services provides a Permitting Assistant (VSPA) for determining import and transit requirements located here reason_codes: - code: Regulated pathogen meaning: This construct is associated with a Veterinary Services (VS) regulated livestock or poultry pathogen and may require filing a VS 16-3 Form for import or interstate transport. action: Review constructs associated with Veterinary Services (VS) regulated livestock or poultry pathogens and use the VS Permitting Assistant (VSPA) to determine requirements for transport. - code: Potentially regulated meaning: This construct is associated with a genus of Veterinary Services (VS) regulated livestock or poultry pathogens. The genus may contain both pathogenic and nonpathogenic species and may require filing a VS 16-3 Form for import or interstate transport. action: Review constructs associated with Veterinary Services (VS) regulated livestock or poultry pathogens and use the VS Permitting Assistant (VSPA) to determine requirements for transport. - code: Regulated arthropod vector meaning: This construct is associated with a Veterinary Services (VS) regulated livestock or poultry arthropod vector and may require filing a VS 16-3 Form for import or interstate transport. action: Review constructs associated with Veterinary Services (VS) regulated livestock or poultry arthropod vectors and use the VS Permitting Assistant (VSPA) to determine requirements for transport. - code: Select agent meaning: This construct may be regulated by the US Federal Select Agent Program (FSAP). If the construct doesn't meet requirements for registration with US FSAP, filing a Veterinary Services (VS) 16-3 Form may be required for import or interstate transport. action: Review constructs associated with the US Federal Select Agent Program (FSAP) first to determine authority for transport. If this construct does not meet requirements for registration with US FSAP, use the VS Permitting Assistant (VSPA) to determine requirements for transport.