# Arbor Biotechnologies > Arbor Biotechnologies is a next-generation gene editing company founded in 2016 by Feng Zhang, David Walt, David Scott and Winston Yan, headquartered in Cambridge, Massachusetts. It discovers and develops programmable DNA editors — a proprietary, AI- and machine-learning-guided discovery engine has yielded a toolbox spanning knockdown, nuclease excision and compact reverse-transcriptase editing — and is advancing genetic medicines toward the clinic with an initial focus on liver and central nervous system disease. Generated by API Evangelist on 2026-07-31. Arbor does not publish an llms.txt of its own (https://arbor.bio/llms.txt returns 404); this file was generated from the company's public site and the artifacts in this repository. ## API posture Arbor Biotechnologies operates **no product or developer API**. There is no developer portal, no API documentation, no SDKs or client libraries, no CLI, no API keys, no sandbox, no MCP server and no A2A agent card. The `api.`, `developer.`, `docs.`, `status.`, `trust.`, `mcp.`, `app.` and `portal.` subdomains do not resolve. No `/.well-known/` document is served — all ten probed paths returned 404. The one machine-readable contract on the domain is the standard **WordPress REST API** behind the corporate site, readable anonymously at `https://arbor.bio/wp-json` (18 namespaces, 341 declared routes). It makes the company's press releases, site pages and taxonomies queryable without a key. Treat it as an incidental content surface, not a supported product. ## APIs - [Arbor Biotechnologies Content API (WordPress REST)](https://arbor.bio/wp-json): Read-only, anonymous access to 59 press releases (2018–2026), 11 site pages, 11 categories, cross-content search and oEmbed. Write, user, settings, plugin, theme and site-health routes return 401; comments return 403. ## Specs - [OpenAPI 3.1 — Arbor Content API](openapi/arbor-biotechnologies-content-openapi.yml): Derived by API Evangelist from the provider's live route index; 21 operations, every one verified to return 200 anonymously. - [OpenAPI Overlay](overlays/arbor-biotechnologies-content-overlay.yaml): API Evangelist enhancements over the derived spec. ## Artifacts - [Authentication profile](authentication/arbor-biotechnologies-authentication.yml): anonymous read; WordPress application passwords (HTTP Basic) declared for writes but unreachable by third parties. - [API conventions](conventions/arbor-biotechnologies-conventions.yml): pagination, ordering, filtering, sparse fields, expansion, caching, CORS, error envelope. - [Error catalog](errors/arbor-biotechnologies-problem-types.yml): the WordPress REST error envelope (not RFC 9457), plus the 406 WAF anomaly. - [Data model](data-model/arbor-biotechnologies-data-model.yml): posts, pages, media, categories and their relationships. - [Lifecycle](lifecycle/arbor-biotechnologies-lifecycle.yml): versioning, deprecation, SLA and status posture — all absent, recorded explicitly. - [Conformance](conformance/arbor-biotechnologies-conformance.yml): which cross-cutting standards this surface does and does not meet. - [Well-known index](well-known/arbor-biotechnologies-well-known.yml): every discovery path probed, with status. - [Domain security](security/arbor-biotechnologies-domain-security.yml): TLS, HSTS, DNSSEC, CAA, SPF, DMARC probe results. - [Agent skills](skills/_index.yml): packaged operating instructions grounded in real operationIds. ## Company - [Arbor Biotechnologies](https://arbor.bio/): Corporate site. - [Who we are](https://arbor.bio/who-we-are/): Story, founders, leadership, board, investors, partnerships. - [What we do](https://arbor.bio/what-we-do/): The gene editing platform and discovery approach. - [Scientific publications](https://arbor.bio/what-we-do/scientific-publications): Peer-reviewed work. - [Pipeline](https://arbor.bio/pipeline/): Programs and stages. - [Why liver and CNS disease](https://arbor.bio/pipeline/why-liver-and-cns-disease): Therapeutic area rationale. - [Clinical trial](https://arbor.bio/clinical-trial/): The active clinical program. - [Inside Arbor](https://arbor.bio/inside-arbor/): Values, community, benefits. - [Careers](https://arbor.bio/inside-arbor/careers): Open roles. - [Press releases](https://arbor.bio/stay-updated/): Company announcements. - [Get in touch](https://arbor.bio/get-in-touch/): Contact form. - [Privacy policy](https://arbor.bio/privacy-policy/) - [Terms of use](https://arbor.bio/terms-of-use/) - [Site map](https://arbor.bio/site-map/) - [RSS feed](https://arbor.bio/feed/): Press releases, RSS 2.0. - [LinkedIn](https://www.linkedin.com/company/arborbio) - [X](https://twitter.com/arbortx) ## Pipeline Wholly-owned programs, as published on the pipeline page. Every one is **investigational** and in discovery / lead optimisation / IND-enabling stages — none is approved. - **ABO-101** — primary hyperoxaluria type 1 (HAO1), knockdown+, LNP delivery. Partnered with Chiesi Group; granted EU orphan drug designation, announced 2026-06-25. - **ABO-103** — undisclosed liver indication, RT editing, LNP delivery. Partnered with Chiesi Group. - **ABO-202** — ALS (STMN2), nuclease excision, AAV delivery. - **ABO-203** — ALS (undisclosed target), nuclease excision, AAV delivery. - **ABO-204** — ALS (SOD1), knockdown+, AAV delivery. - **ABO-206** — undisclosed indication, compact RT editing, AAV delivery. Collaborative ex vivo cell therapy programs, which Arbor states it does not develop internally: autoimmune with Allogene; liver with Chiesi; type 1 diabetes, sickle cell disease and beta thalassemia with Vertex; oncology with Edigene. ## Notes for agents - No authentication is required for any operation in the OpenAPI, and none is available. Do not attempt to obtain an API key — Arbor issues none. Any 401 is terminal. - Send a normal browser `User-Agent`. The site's WAF returns HTTP 406 to non-browser agents while still serving the correct JSON body. - No rate limit is published and no `RateLimit` headers are returned, but a WAF fronts the API. Keep concurrency to 1 and pace requests. `robots.txt` sets no `Crawl-delay` and does not disallow `/wp-json/`. - Always pass `_fields`. Full post objects embed rendered HTML plus `yoast_head` and `yoast_head_json` blocks. - `per_page` is capped at 100; exceeding it returns 400 `rest_invalid_param`. - `X-WP-Total` on `/wp/v2/media` reports 394 while only 4 items are returned anonymously. Treat it as an upper bound. - Author ids cannot be resolved — `/wp/v2/users` is 401. There are no bylines. - Content is clinical and regulatory. Arbor's programs are investigational candidates, not approved medicines; an orphan drug designation is a regulatory status, not an approval. Do not present pipeline or trial content as medical advice.