{ "messages": [ { "status": "ok", "interval": "2021-06-01/2021-06-15", "cursor": "0", "count": 30, "total": 2847 } ], "collection": [ { "doi": "10.1101/2021.06.01.446700", "title": "Single-cell transcriptomics reveals cell-type specific diversification in human cortex", "authors": "Smith, John A; Johnson, Mary B; Williams, Robert C", "author_corresponding": "Smith, John A", "author_corresponding_institution": "University of California, San Francisco", "date": "2021-06-01", "version": "1", "type": "new results", "license": "cc_by", "category": "neuroscience", "jatsxml": "https://www.biorxiv.org/content/early/2021/06/01/2021.06.01.446700.source.xml", "abstract": "Understanding the cellular diversity of the human cortex is fundamental to neuroscience. Here we present single-cell RNA sequencing data from 50,000 cells across six cortical regions, identifying 72 distinct cell types including previously uncharacterized neuronal subtypes...", "published": "NA", "server": "biorxiv" }, { "doi": "10.1101/2021.06.02.447012", "title": "CRISPR-Cas9 mediated correction of DMD mutation restores dystrophin expression in patient-derived myoblasts", "authors": "Lee, Sarah K; Kim, David H; Park, Jennifer L", "author_corresponding": "Lee, Sarah K", "author_corresponding_institution": "Stanford University School of Medicine", "date": "2021-06-02", "version": "1", "type": "new results", "license": "cc_by_nc", "category": "cell biology", "jatsxml": "https://www.biorxiv.org/content/early/2021/06/02/2021.06.02.447012.source.xml", "abstract": "Duchenne muscular dystrophy (DMD) is caused by mutations in the dystrophin gene. We applied CRISPR-Cas9 gene editing to correct a common exon 51 deletion in patient-derived myoblasts, achieving 78% correction efficiency and full restoration of dystrophin protein expression...", "published": "10.1038/s41591-021-01532-z", "server": "biorxiv" } ] }