aid: chempirical name: Chempirical image: https://chempirical.com/og-image.png description: Chempirical (operated as Nitramine per the submission) publishes free tools for chemists and a free, keyless, read-only JSON API at chempirical.com/api covering compounds (names, formula, SMILES/InChI identifiers, molar mass, density, melting and boiling points, Antoine constants, azeotropes), substructure and similarity search, structure SVGs, reactions with participants and reaction scaling. CORS is open; the docs ask for a few requests per second. url: https://raw.githubusercontent.com/api-evangelist/chempirical/refs/heads/main/apis.yml x-type: company x-source: harvest:new-submission x-tier: profiled x-tier-reason: enrichment pass 2026-10-09 (local-v5; was harvest) specificationVersion: '0.20' created: '2026-10-09' modified: '2026-10-09' tags: - Company - Chemistry - Compounds - Reactions - Science - Open Data - JSON API maintainers: - FN: Kin Lane email: kin@apievangelist.com - FN: APIs.json email: info@apis.io common: - type: RateLimits url: rate-limits/chempirical-rate-limits.yml - type: Plans url: plans/chempirical-plans-pricing.yml - type: Spectral url: rules/chempirical-rules.yml - type: JSONLD url: json-ld/chempirical-context.jsonld - type: Vocabulary url: vocabulary/chempirical-vocabulary.yml - type: DataModel url: data-model/chempirical-data-model.yml - type: Conventions url: conventions/chempirical-conventions.yml - type: Conformance url: conformance/chempirical-conformance.yml - type: Hosts url: hosts/chempirical-hosts.yml - type: DomainSecurity url: security/chempirical-domain-security.yml - type: Website url: https://chempirical.com - type: Documentation url: https://chempirical.com/api/ - type: Blog url: https://chempirical.com/blog/ - type: Login url: https://chempirical.com/auth/login apis: - aid: chempirical:chempirical-chempirical-nitramine-api-api name: Chempirical Chempirical (Nitramine) API description: >- The Chempirical (Nitramine) API API from Chempirical — 1 operation(s) for chempirical (nitramine) api. humanURL: https://chempirical.com/api/ baseURL: https://chempirical.com/api tags: - Chempirical (Nitramine) API properties: - type: OpenAPI url: openapi/chempirical-chempirical-nitramine-api-api-openapi.yml - type: JSONSchema url: json-schema/chempirical-get-api-molecules-moleculeid-response-schema.json - type: JSONSchema url: json-schema/chempirical-get-api-reactions-henry-nitroaldol-response-schema.json - type: JSONSchema url: json-schema/chempirical-get-api-apiid-response-schema.json - type: JSONSchema url: json-schema/chempirical-get-api-reactions-henry-nitroaldol-scale-response-schema.json - type: JSONSchema url: json-schema/chempirical-post-api-molecules-moleculeid-response-schema.json - type: JSONSchema url: json-schema/chempirical-get-api-molecule-svg50782-response-schema.json - aid: chempirical:chempirical-molecule-svg-api name: Chempirical Molecule Svg API description: The Molecule Svg API from Chempirical — 1 operation(s) for molecule svg. humanURL: https://chempirical.com/api/ baseURL: https://chempirical.com/api tags: - Molecule Svg properties: - type: OpenAPI url: openapi/chempirical-molecule-svg-api-openapi.yml - type: JSONSchema url: json-schema/chempirical-get-api-molecules-moleculeid-response-schema.json - type: JSONSchema url: json-schema/chempirical-get-api-reactions-henry-nitroaldol-response-schema.json - type: JSONSchema url: json-schema/chempirical-get-api-apiid-response-schema.json - type: JSONSchema url: json-schema/chempirical-get-api-reactions-henry-nitroaldol-scale-response-schema.json - type: JSONSchema url: json-schema/chempirical-post-api-molecules-moleculeid-response-schema.json - type: JSONSchema url: json-schema/chempirical-get-api-molecule-svg50782-response-schema.json - aid: chempirical:chempirical-molecules-api name: Chempirical Molecules API description: The Molecules API from Chempirical — 1 operation(s) for molecules. humanURL: https://chempirical.com/api/ baseURL: https://chempirical.com/api tags: - Molecules properties: - type: OpenAPI url: openapi/chempirical-molecules-api-openapi.yml - type: JSONSchema url: json-schema/chempirical-get-api-molecules-moleculeid-response-schema.json - type: JSONSchema url: json-schema/chempirical-get-api-reactions-henry-nitroaldol-response-schema.json - type: JSONSchema url: json-schema/chempirical-get-api-apiid-response-schema.json - type: JSONSchema url: json-schema/chempirical-get-api-reactions-henry-nitroaldol-scale-response-schema.json - type: JSONSchema url: json-schema/chempirical-post-api-molecules-moleculeid-response-schema.json - type: JSONSchema url: json-schema/chempirical-get-api-molecule-svg50782-response-schema.json - aid: chempirical:chempirical-reactions-api name: Chempirical Reactions API description: The Reactions API from Chempirical — 2 operation(s) for reactions. humanURL: https://chempirical.com/api/ baseURL: https://chempirical.com/api tags: - Reactions properties: - type: OpenAPI url: openapi/chempirical-reactions-api-openapi.yml - type: JSONSchema url: json-schema/chempirical-get-api-molecules-moleculeid-response-schema.json - type: JSONSchema url: json-schema/chempirical-get-api-reactions-henry-nitroaldol-response-schema.json - type: JSONSchema url: json-schema/chempirical-get-api-apiid-response-schema.json - type: JSONSchema url: json-schema/chempirical-get-api-reactions-henry-nitroaldol-scale-response-schema.json - type: JSONSchema url: json-schema/chempirical-post-api-molecules-moleculeid-response-schema.json - type: JSONSchema url: json-schema/chempirical-get-api-molecule-svg50782-response-schema.json x-submission-notes: Free keyless chemistry JSON API (compounds, reactions) x-submission-probe: /api/ 200 HTML docs; /openapi.json and /api/openapi.json 404 (no contract found); invented path 404 x-submitted-by: marty@chempirical.com (apis.io/add, 2026-10-09) x-coverage: state: unreadable reason: no-machine-readable-spec method: derived generated: '2026-10-09' generator: derive-coverage.py (pre-flight evidence) detail: the company publishes developer documentation but serves no machine-readable contract from it evidence: - url: https://chempirical.com status: 200 x-enrichment: date: '2026-10-09' status: enriched artifacts_added: 14 pass: local-v5