aid: cullgen
name: Cullgen
image: https://images.squarespace-cdn.com/content/64fa49d6dc6a8807524aa6c6/6a0a0ac8-3bf2-40b4-9f81-547d92175843/cullgen+logo+with+drop+shadow+more+blurry.png?format=1500w&content-type=image%2Fpng
description: 'Cullgen Inc. is a clinical-stage biopharmaceutical company headquartered in San Diego,
  California, founded in 2018 and focused on first-in-class targeted protein degradation medicines. Its
  proprietary uSMITE (ubiquitin-mediated, small molecule-induced target elimination) platform harnesses
  the body''s own ubiquitin-proteasome system to selectively degrade disease-causing intracellular
  proteins, including targets considered undruggable by conventional small molecules, and the company
  extends that chemistry into degrader-antibody conjugates (DACs). Its lead TRK degrader program has
  entered Phase 1 clinical dosing, and the company has partnered with Astellas and taken investment from
  AstraZeneca. Gyre Therapeutics completed an all-stock acquisition of Cullgen valued at approximately
  $300 million on 4 May 2026. Cullgen publishes a corporate marketing website only: profiling on
  2026-08-04 found no developer portal, documentation, machine-readable API contract, package registry
  presence, or public code repositories.'
url: https://raw.githubusercontent.com/api-evangelist/cullgen/refs/heads/main/apis.yml
x-type: company
x-source: harvest:secondary-market
x-tier: stub
x-tier-reason: harvest
x-api-surface: none
specificationVersion: '0.23'
created: '2026-08-04'
modified: '2026-08-04'
tags:
- Company
- Biotechnology
- Pharmaceuticals
- Life Sciences
- Drug Discovery
- Targeted Protein Degradation
- Oncology
- Clinical Stage
apis: []
maintainers:
- FN: Kin Lane
  email: kin@apievangelist.com
- FN: APIs.json
  email: info@apis.io
common:
- type: DomainSecurity
  url: security/cullgen-domain-security.yml
- type: LLMsTxt
  url: llms/cullgen-llms.txt
- type: Website
  url: https://www.cullgen.com/
- type: About
  url: https://www.cullgen.com/about-us
- type: Blog
  url: https://www.cullgen.com/news-press-releases
- type: Contact
  url: https://www.cullgen.com/contact-us
- type: Careers
  url: https://www.cullgen.com/careers-1
- type: LinkedIn
  url: https://www.linkedin.com/company/cullgen
- type: Twitter
  url: https://twitter.com/CullgenInc
- type: SecondaryMarket
  url: https://forgeglobal.com/cullgen_stock/
x-enrichment:
  date: '2026-08-04'
  status: minimal
  artifacts_added: 2
  pass: local-v1