# Engrail Therapeutics

> Engrail Therapeutics is a clinical-stage precision-neuroscience pharmaceutical company founded in 2019 and headquartered in San Diego, California. It develops targeted small-molecule therapies for neuropsychiatric and neurodevelopmental diseases — generalized anxiety disorder, anhedonic depression, PTSD and rare neurodegenerative conditions. Lead program ENX-102 is a selective GABA-A alpha-2,3,5 positive allosteric modulator in Phase 2 (ENCALM) for generalized anxiety disorder; ENX-104 is in clinical development for major depressive disorder characterized by anhedonia. The company raised an oversubscribed $157M Series B in March 2024 and has raised over $220M since inception.

## What is and is not here

Engrail publishes **no product API and no developer program**. There is no developer portal, no documentation, no SDK, no CLI, no changelog, no status page, and no OpenAPI of the company's own authorship. This file was GENERATED by API Evangelist on 2026-08-01 — the provider serves no llms.txt at https://www.engrail.com/llms.txt (HTTP 404).

Two machine-readable surfaces do exist on the corporate website, and they are the reason this company carries API artifacts at all:

1. A public, anonymously-readable **WordPress REST content API** at `https://www.engrail.com/wp-json/wp/v2`.
2. Two **OAuth-protected Model Context Protocol (MCP) servers** under the `mcp` REST namespace, fronted by RFC 8414 and RFC 9728 discovery documents at the apex. Both reject anonymous `tools/list` with HTTP 401, so their tool manifests are not public.

## APIs

- [Site Content API](https://www.engrail.com/wp-json/wp/v2): 16 public read operations over posts, pages, media, categories, tags, comments, and the site's type/taxonomy/status vocabulary, plus site search. Page-number pagination (`page`, `per_page` max 100) with `X-WP-Total`, `X-WP-TotalPages` and an RFC 8288 `Link` header. Sparse fields via `_fields`, expansion via `_embed`.
- [MCP servers](https://www.engrail.com/wp-json/mcp): `mcp-oauth-server` and `mcp-adapter-default-server`. OAuth 2.1 authorization-code + PKCE S256, single scope `mcp`, public clients only, client identity by client-id metadata document.

## Specs and artifacts

- [OpenAPI (derived)](openapi/engrail-therapeutics-content-openapi.yml): OpenAPI 3.1.0, 16 operations, derived mechanically from the host's own route-discovery document at https://www.engrail.com/wp-json/ .
- [Overlay](overlays/engrail-therapeutics-content-overlay.yaml): API Evangelist enhancements, provenance and cross-links.
- [MCP manifest](mcp/engrail-therapeutics-mcp.yml): both servers, their auth model, and the recorded 401 probes. No tool list — it is auth-gated and was not guessed.
- [Tool crosswalk](mcp/engrail-therapeutics-tool-crosswalk.yml): REST-only capabilities enumerated; MCP binding blocked on authenticated introspection.
- [Authentication](authentication/engrail-therapeutics-authentication.yml): Application Passwords for content, OAuth 2.1 for MCP.
- [OAuth scopes](scopes/engrail-therapeutics-scopes.yml): a single coarse `mcp` scope.
- [Conventions](conventions/engrail-therapeutics-conventions.yml): pagination, filtering, field selection, versioning, error envelope, rate-limit signalling.
- [Error catalog](errors/engrail-therapeutics-problem-types.yml): five error codes captured live; WordPress envelope, not RFC 9457.
- [Data model](data-model/engrail-therapeutics-data-model.yml): entity graph derived from id-reference parameters.
- [Well-known index](well-known/engrail-therapeutics-well-known.yml): what the apex serves and what it does not.
- [Conformance](conformance/engrail-therapeutics-conformance.yml): standards asserted with evidence, and the real absences.
- [Lifecycle](lifecycle/engrail-therapeutics-lifecycle.yml): versioning namespaces; no deprecation policy, SLA or status page.
- [Domain security](security/engrail-therapeutics-domain-security.yml): TLS 1.3, HSTS 63072000, SPF and DMARC (quarantine) present; no DNSSEC, no CAA.
- [Agent skills](skills/_index.yml): packaged operating instructions grounded in real operationIds.

## Company

- [Home](https://www.engrail.com/)
- [About Us](https://www.engrail.com/about-us/)
- [Our Science](https://www.engrail.com/our-science/)
- [Pipeline](https://www.engrail.com/pipeline/)
- [Partners](https://www.engrail.com/partners/)
- [Investors & Media](https://www.engrail.com/investors-media/)
- [Careers](https://www.engrail.com/careers/)
- [Contact Us](https://www.engrail.com/contact-us/)

## Legal

- [Terms of Use](https://www.engrail.com/terms-of-use/)
- [Privacy Policy](https://www.engrail.com/privacy-policy/)
- [Legal Disclaimer](https://www.engrail.com/legal-disclaimer/)

## Optional

- [News feed (RSS)](https://www.engrail.com/feed/)
- [LinkedIn](https://www.linkedin.com/company/engrail-therapeutics)
- [Forge Global secondary-market profile](https://forgeglobal.com/engrail-therapeutics_stock/)