aid: hotspot-therapeutics
name: HotSpot Therapeutics
description: 'HotSpot Therapeutics is a clinical-stage biopharmaceutical company headquartered
  in Boston, Massachusetts, pioneering allosteric drug discovery by targeting "natural
  hotspots" — the regulatory on/off switches on proteins. Its Smart Allostery platform
  combines AI-driven mining of large, diverse structural and biological data sets with
  a tailored pharmacology toolkit and bespoke medicinal chemistry to design first-in-class
  oral small molecules, and has been applied across E3 ligases, kinases and transcription
  factors. The company has raised roughly $190M across Series A, B and C financings and
  advanced its lead candidate HST-1011, an oral allosteric CBL-B inhibitor, into first-in-human
  dosing for cancer, alongside programs in autoimmune disease. HotSpot sells medicines
  and research collaborations, not software: it publishes no public developer program,
  API, SDK or machine-readable contract of any kind.'
image: https://avatars.githubusercontent.com/u/105356575?v=4
url: https://raw.githubusercontent.com/api-evangelist/hotspot-therapeutics/refs/heads/main/apis.yml
x-type: company
x-source: harvest:secondary-market
x-tier: stub
x-tier-reason: harvest
specificationVersion: '0.20'
created: '2026-08-22'
modified: '2026-08-22'
tags:
- Company
- Biotechnology
- Pharmaceuticals
- Drug Discovery
- Life Sciences
- Oncology
- Immunology
- Artificial Intelligence
- Health
apis: []
maintainers:
- FN: Kin Lane
  email: kin@apievangelist.com
- FN: APIs.json
  email: info@apis.io
common:
- type: DomainSecurity
  url: security/hotspot-therapeutics-domain-security.yml
- type: Website
  url: https://www.hotspotthera.com/
- type: GitHubOrganization
  url: https://github.com/HotSpot-Therapeutics
- type: Blog
  url: https://www.hotspotthera.com/blog/
- type: PrivacyPolicy
  url: https://www.hotspotthera.com/privacy-policy/
- type: TermsOfService
  url: https://www.hotspotthera.com/terms-and-conditions/
- type: SecondaryMarketListing
  url: https://forgeglobal.com/hotspot-therapeutics_stock/
x-enrichment:
  date: '2026-08-22'
  status: minimal
  artifacts_added: 2
  pass: local-v1
x-coverage:
  state: none
  reason: not-a-software-company
  detail: >-
    HotSpot Therapeutics is a clinical-stage biopharmaceutical company whose product
    is an oral small-molecule drug pipeline (HST-1011, a CBL-B allosteric inhibitor),
    not software — its "Smart Allostery" AI platform is an internal discovery engine
    with no external interface, no api./docs./developer. host resolves in DNS, every
    /.well-known/ path 404s, and its only public GitHub repo is a fork of the
    third-party SETH bioinformatics tool.
  evidence:
  - url: https://www.hotspotthera.com/.well-known/api-catalog
    status: 404
  - url: https://www.hotspotthera.com/llms.txt
    status: 404
  - url: https://hotspotthera.com/.well-known/agent-card.json
    status: 404
  - url: https://api.github.com/orgs/HotSpot-Therapeutics/repos
    status: 200
  checked: '2026-08-22'