aid: intarcia-therapeutics
name: Intarcia Therapeutics
description: >-
  Intarcia Therapeutics, Inc. was a Boston-headquartered clinical-stage biopharmaceutical and
  drug-delivery company, founded in 1997 and once valued at roughly $5.5B, that developed the
  Medici Drug Delivery System — a matchstick-sized subdermal osmotic mini-pump engineered to
  stabilize therapeutic proteins and peptides at body temperature and release them continuously
  for months from a single placement. Its lead candidate, ITCA 650, delivered the GLP-1 receptor
  agonist exenatide for type 2 diabetes over three- to six-month intervals. The FDA issued
  complete response letters on the ITCA 650 new drug application in 2017 and again in 2020, after
  which the company ran out of capital, laid off staff, closed its Boston, Hayward (CA) and
  Durham (NC) sites and liquidated its manufacturing and laboratory equipment at auction. Its
  remaining assets — the Medici platform and ITCA 650 — were acquired by i2o Therapeutics in
  August 2023, and FDA published a final decision refusing to approve the ITCA 650 application on
  2024-08-23. Intarcia was a drug-device developer rather than a software company: its corporate
  site carried only Medici System, Pipeline, Newsroom, About, Leadership and Careers sections and
  never published a developer program, public API, SDK, webhook surface or machine-readable
  specification of any kind. As of 2026-08-23 both intarcia.com and intarciatherapeutics.com
  resolve to an Atom.com domain-broker parking page that offers the names for sale and returns
  HTTP 404 on every path, and no developer-facing subdomain resolves. This profile is retained as
  a historical record; there is no API surface to enrich.
url: https://raw.githubusercontent.com/api-evangelist/intarcia-therapeutics/refs/heads/main/apis.yml
x-type: company
x-source: harvest:secondary-market
x-secondary-market-listing: https://forgeglobal.com/intarcia-therapeutics_stock/
x-tier: stub
x-tier-reason: defunct-no-api-surface
x-status: defunct
x-shutdown-note: >-
  Wound down after the FDA's second complete response letter in 2020; equipment liquidated at
  auction and the Medici / ITCA 650 assets acquired by i2o Therapeutics in August 2023. FDA
  published its final decision refusing approval of ITCA 650 on 2024-08-23.
x-successor: i2o Therapeutics (acquired the Medici Drug Delivery System and ITCA 650, 2023-08)
x-domain-status: parked-for-sale
x-domain-note: >-
  intarcia.com and intarciatherapeutics.com both resolve to 52.20.84.62 on ns1/ns2.atom.com and
  serve an Atom.com domain-broker landing page. Every /.well-known/ and spec path returns a hard
  HTTP 404 (679 bytes, identical to a nonsense control path), so there are no soft-200 false
  positives to guard against. These hosts are NOT company-controlled and are deliberately not
  wired as a Website pointer. See well-known/intarcia-therapeutics-well-known.yml.
x-venue-listing-note: >-
  The Forge Global secondary-market page this company was harvested from is recorded above as
  x-secondary-market-listing and is deliberately NOT wired as a common[] Website pointer — a
  trading-venue listing is not a company web presence (network roadmap#56).
specificationVersion: '0.23'
created: '2026-08-23'
modified: '2026-08-23'
tags:
- Company
- Defunct
- Biotechnology
- Pharmaceuticals
- Drug Delivery
- Medical Devices
- Diabetes
- Health
- Life Sciences
apis: []
maintainers:
- FN: Kin Lane
  email: kin@apievangelist.com
- FN: APIs.json
  email: info@apis.io
common: []
x-coverage:
  state: none
  reason: defunct
  detail: >-
    Intarcia Therapeutics wound down after the FDA's 2020 complete response letter and sold the
    Medici / ITCA 650 assets to i2o Therapeutics in 2023; intarcia.com and
    intarciatherapeutics.com are now an Atom.com domain-broker parking page that hard-404s every
    /.well-known/ and spec path, and api., developer., docs., portal., dev. and app. subdomains
    do not resolve at all.
  evidence:
  - url: https://intarcia.com/
    status: 403
  - url: https://intarcia.com/zzz-control-nonsense-xyz789
    status: 404
  - url: https://intarcia.com/openapi.json
    status: 404
  - url: https://intarcia.com/llms.txt
    status: 404
  - url: https://intarcia.com/.well-known/agent-card.json
    status: 404
  - url: https://intarciatherapeutics.com/.well-known/agent.json
    status: 404
  - url: https://api.github.com/orgs/intarcia
    status: 200
  - url: https://forgeglobal.com/intarcia-therapeutics_stock/
    status: 403
  checked: '2026-08-23'
x-enrichment:
  date: '2026-08-23'
  status: nochange
  artifacts_added: 1
  pass: local-v1