generated: '2026-08-23'
method: searched
source: >-
  https://pypi.org/pypi/hydrascreen/json, https://api.github.com/orgs/Ro5-ai/repos, and negative
  lookups on registry.npmjs.org and pypi.org for juvenescence/juvlabs
note: >-
  Juvenescence publishes no client library for its own domain. The one first-party package in this
  file arrives through the Ro5 Inc. acquisition (announced 5 June 2025 on juvlabs.com); ro5.ai now
  301s to juvlabs.com, which is the evidence that the Ro5-ai GitHub organisation and its PyPI
  releases are Juvenescence property. IMPORTANT DECAY SIGNAL: hydrascreen 0.0.8 was last published
  2023-12-18 and the API host it wraps, hydrascreen-api.ro5.ai, no longer resolves in DNS as of
  2026-08-23 — the SDK is installable but its backing service is gone. See
  lifecycle/juvenescence-lifecycle.yml.
official_count: 1
packages:
- language: python
  registry: pypi
  name: hydrascreen
  url: https://pypi.org/project/hydrascreen/
  install: pip install hydrascreen
  official: true
  version: 0.0.8
  published: '2023-12-18'
  repository: https://github.com/Ro5-ai/hydrascreen
  license: Non-commercial
  publisher: Ro5 Inc. (acquired by Juvenescence Limited, June 2025)
  wraps: https://hydrascreen-api.ro5.ai/v2
  status: backing-service-unreachable
  note: >-
    Python client for the HydraScreen structure-based drug-discovery API — email/organisation login
    that mails back a JWT, PDB protein upload, SDF ligand upload, and a protein-ligand affinity and
    pose-confidence inference call. Six releases (0.0.3 through 0.0.8); the latest is 0.0.8, published
    2023-12-18, more than two and a half years before this probe. The base URL compiled into the
    package, https://hydrascreen-api.ro5.ai/v2, returned NXDOMAIN on 2026-08-23, as did the companion
    GUI host hydrascreen.ro5.ai, so the package can be installed but cannot reach a service.
repositories:
- name: Ro5-ai/hydrascreen
  url: https://github.com/Ro5-ai/hydrascreen
  language: Python
  official: true
  distributed_as: pypi:hydrascreen
  last_push: '2024-06-25'
  note: Source of the hydrascreen PyPI package, plus the paper code release for the HydraScreen model.
- name: Ro5-ai/bio2d_public
  url: https://github.com/Ro5-ai/bio2d_public
  language: Python
  official: true
  distributed_as: null
  registry: null
  version: null
  published: null
  last_push: '2025-06-10'
  note: >-
    Research code accompanying "Benchmarking ML in ADMET Predictions". Checked, nothing to record for
    version/published — this repository is not published to PyPI or any other registry and has no
    tagged release, so there is no registry metadata endpoint to read. It is a reproducibility
    artifact, not a client library, and is not counted in official_count.
registries_checked:
- registry: npm
  queries:
  - name: juvenescence
    status: 404
  - name: juvlabs
    status: 404
  - name: ro5
    status: 404
- registry: pypi
  queries:
  - name: hydrascreen
    status: 200
  - name: juvenescence
    status: 404
  - name: juvlabs
    status: 404
- registry: github-org
  queries:
  - name: juvlabs
    status: 200
    public_repos: 0
    note: Organisation exists (created 2021-10-20) but publishes zero public repositories.
  - name: Ro5-ai
    status: 200
    public_repos: 2
  - name: juvenescence
    status: 404