aid: manus-bio
name: Manus Bio
image: https://cdn.prod.website-files.com/6536fe08e98c41581598326f/6682ee89aa355ed6e2dca105_Manus%20Social%20Image.png
description: 'Manus Bio Inc. (trading as "Manus", the BioAlternatives Company) is a Cambridge,
  Massachusetts industrial biotechnology company founded in 2011 out of MIT by Dr. Aji Parayil
  and Dr. Greg Stephanopoulos. Manus engineers microbial cell factories and precision-fermentation
  processes so that complex molecules normally obtained through petrochemical synthesis, agricultural
  extraction, or animal husbandry can be produced by fermentation instead - what the company calls
  bioalternatives. Its commercialized products include the first U.S. commercial-scale monk fruit
  sweetener (produced at its Augusta, Georgia BioFacility), the Yume M stevia Reb M sweetener
  co-developed with Tate & Lyle, citrus-derived aroma ingredients (Nootkatone 70, Valencene 80,
  BioNootkatone) for Givaudan, and an artemisinin antimalarial program funded by HHS/ASPR. It sells
  scale-up services through its BioAccelerator and BioManufacturing programs (protein engineering,
  strain development, bioprocess development from 250 ml to 3,000 L, pilot-scale and biomanufacturing).
  In April 2025 Manus merged with genome-engineering company Inscripta, adding whole-genome editing
  technology and the MAD7 CRISPR nuclease licensing program; inscripta.com is now a redirect notice.
  Manus is a manufacturer of physical ingredients and a contract development and manufacturing
  organization - it sells molecules and services, not software. It publishes no public API, developer
  portal, SDK, webhook surface, or machine-readable specification of any kind, and its computational
  and AI-driven enzyme-engineering tools are internal capabilities that support its services rather
  than a customer-facing platform.'
url: https://raw.githubusercontent.com/api-evangelist/manus-bio/refs/heads/main/apis.yml
x-type: company
x-source: harvest:secondary-market
x-source-url: https://forgeglobal.com/manus-bio_stock/
x-tier: stub
x-tier-reason: harvest
x-status: active
x-merged-with: inscripta
x-merged-date: '2025-04'
x-references:
- name: 'Manus: Manus and Inscripta merge to create a leader in industrial biomanufacturing'
  url: https://www.manusbio.com/articles/manus-and-inscripta-merge-to-create-a-leader-in-industrial-biomanufacturing
- name: 'Manus: Made in America - the first monk fruit sweetener produced in the U.S. at commercial scale'
  url: https://www.manusbio.com/articles/made-in-america-manus-unveils-the-first-monk-fruit-sweetener-produced-in-the-u-s-at-commercial-scale
- name: 'CU Boulder Venture Partners: Inscripta Inc. (now Manus Bio Inc.)'
  url: https://www.colorado.edu/venturepartners/startup-portfolio/inscripta-inc-now-manus-bio-inc
specificationVersion: '0.23'
created: '2026-08-04'
modified: '2026-08-04'
tags:
- Company
- Biotechnology
- Synthetic Biology
- Biomanufacturing
- Industrial Biotechnology
- Precision Fermentation
- Ingredients
- Food and Beverage
- Sustainability
- Life Sciences
apis: []
maintainers:
- FN: Kin Lane
  email: kin@apievangelist.com
- FN: APIs.json
  email: info@apis.io
common:
- type: Website
  name: Manus
  url: https://www.manusbio.com/
- type: About
  name: About Manus
  url: https://www.manusbio.com/about
- type: Blog
  name: Insights and News
  url: https://www.manusbio.com/insights-and-news
- type: Contact
  name: Contact
  url: https://www.manusbio.com/contact
- type: Careers
  name: Careers
  url: https://www.manusbio.com/careers
- type: TermsOfService
  name: Terms and Conditions
  url: https://www.manusbio.com/terms-and-conditions
- type: PrivacyPolicy
  name: Cookie and Privacy Policy
  url: https://www.manusbio.com/cookie-and-privacy-policy
- type: GitHubOrganization
  name: ManusBio on GitHub
  url: https://github.com/ManusBio
  description: Organization account exists (created 2025-08-22) but publishes zero public repositories.
- type: DomainSecurity
  name: Domain Security
  url: security/manus-bio-domain-security.yml
x-enrichment:
  date: '2026-08-04'
  status: minimal
  artifacts_added: 1
  pass: local-v1
x-coverage:
  state: none
  reason: not-a-software-company
  detail: Manus sells fermentation-produced ingredients and contract biomanufacturing services, not
    software; its Webflow marketing site returns 404 for every contract-discovery path, no api./docs./developer.
    subdomain resolves, and the github.com/ManusBio organization has zero public repositories.
  evidence:
  - url: https://www.manusbio.com/openapi.json
    status: 404
  - url: https://www.manusbio.com/llms.txt
    status: 404
  - url: https://www.manusbio.com/.well-known/security.txt
    status: 404
  - url: https://www.manusbio.com/.well-known/agent-card.json
    status: 404
  - url: https://www.manusbio.com/.well-known/agent.json
    status: 404
  - url: https://www.manusbio.com/sitemap.xml
    status: 200
  - url: https://www.inscripta.com/
    status: 200
  - url: https://api.github.com/orgs/manusbio
    status: 200
  checked: '2026-08-04'