openapi: 3.0.3
info:
  title: ClinicalTrials.gov REST BioSample Organelle API
  description: This API is made available to provide users meta data, statistics, and the most recent version of the clinical trials available on ClinicalTrials.gov.
  version: 2.0.5
servers:
- url: https://clinicaltrials.gov/api/v2
  description: This server
tags:
- name: Organelle
  description: '#### Options to download RefSeq organelle genome data, including the associated sequence and metadata.

    These organelle services allow you to get RefSeq organelle genome metadata as a data report or download gene, transcript and protein sequence, and metadata, as an organelle data package, for RefSeq organelle genomes.

    '
paths:
  /organelle/accession/{accessions}/download:
    get:
      summary: Get an organelle data package by nucleotide accession
      description: Download an organelle data package including sequence, annotation, and detailed data reports as a compressed zip archive.
      tags:
      - Organelle
      operationId: download_organelle_package
      responses:
        default:
          description: An unexpected error response.
          content:
            text/plain:
              schema:
                $ref: '#/components/schemas/rpcStatus'
        '200':
          description: A successful response
          content:
            application/zip:
              schema:
                format: binary
                type: string
                description: Zip compressed stream
      parameters:
      - name: accessions
        description: NCBI organelle assembly accessions
        in: path
        required: true
        schema:
          type: array
          items:
            type: string
        examples:
          example-0:
            value: NC_001643.1
            summary: Chimpanzee mitochondrial genome
          example-1:
            value:
            - NC_001643.1
            - NC_002082.1
            summary: Chimpanzee and common Gibbon mitochondrial genomes
      - name: include_annotation_type
        description: Specify which sequence files to include in the data package.
        in: query
        required: false
        schema:
          type: array
          items:
            $ref: '#/components/schemas/v2AnnotationForOrganelleType'
      - name: filename
        description: Output file name.
        in: query
        required: false
        schema:
          type: string
          default: ncbi_dataset.zip
  /organelle/download:
    post:
      summary: Get an organelle data package
      description: Download an organelle data package including sequence, annotation, and detailed data reports as a compressed zip archive.
      tags:
      - Organelle
      operationId: download_organelle_package_by_post
      responses:
        default:
          description: An unexpected error response.
          content:
            text/plain:
              schema:
                $ref: '#/components/schemas/rpcStatus'
        '200':
          description: A successful response
          content:
            application/zip:
              schema:
                format: binary
                type: string
                description: Zip compressed stream
      requestBody:
        required: true
        content:
          application/json:
            schema:
              $ref: '#/components/schemas/v2OrganelleDownloadRequest'
            examples:
              Single organelle accession example:
                description: Organelle accession (just one)
                value:
                  accessions:
                  - NC_001643.1
      parameters:
      - name: filename
        description: Output file name.
        in: query
        required: false
        schema:
          type: string
          default: ncbi_dataset.zip
  /organelle/accessions/{accessions}/dataset_report:
    get:
      summary: Get an organelle data report by nucleotide accession
      description: Get an organelle data report in JSON format.
      tags:
      - Organelle
      operationId: organelle_datareport_by_accession
      responses:
        default:
          description: An unexpected error response.
          content:
            text/plain:
              schema:
                $ref: '#/components/schemas/rpcStatus'
        '200':
          description: A successful response
          content:
            application/json:
              schema:
                $ref: '#/components/schemas/v2reportsOrganelleDataReports'
            application/x-ndjson:
              schema:
                $ref: '#/components/schemas/v2reportsOrganelleDataReports'
            text/tab-separated-values:
              schema:
                type: string
      parameters:
      - name: accessions
        description: One or more organelle nucleotide accessions
        in: path
        required: true
        schema:
          type: array
          items:
            type: string
        examples:
          example-0:
            value: NC_001643.1
            summary: Chimpanzee mitochondrial genome
          example-1:
            value:
            - NC_001643.1
            - NC_002082.1
            summary: Chimpanzee and common gibbon mitochondrial genomes
      - name: organelle_types
        description: Limit results to the specified organelle types.
        in: query
        required: false
        schema:
          type: array
          items:
            $ref: '#/components/schemas/v2reportsOrganelleType'
      - name: first_release_date
        description: Limit results to organelle genomes released on or after the specified date.
        in: query
        required: false
        schema:
          type: string
          format: date-time
        examples:
          example-0:
            value: '2015-01-10'
            summary: Jan 10, 2015, in ISO 8601 YYYY-MM-DD format
      - name: last_release_date
        description: Limit results to organelle genomes released on or before the specified date.
        in: query
        required: false
        schema:
          type: string
          format: date-time
        examples:
          example-0:
            value: '2021-01-10'
            summary: Jan 10, 2021, in ISO 8601 YYYY-MM-DD format
      - name: sort.field
        in: query
        required: false
        schema:
          type: string
      - name: sort.direction
        in: query
        required: false
        schema:
          $ref: '#/components/schemas/v2SortDirection'
      - name: returned_content
        description: Return complete organelle reports or nucleotide accessions only.
        in: query
        required: false
        schema:
          $ref: '#/components/schemas/v2OrganelleMetadataRequestContentType'
        examples:
          example-0:
            value: ASSM_ACC
            summary: Return nucleotide accessions only
      - name: table_format
        description: 'Specify a predefined set of fields for the tabular report using built-in templates. Use of this parameter requires the HTTP header, `accept: text/tab-separated-values`.'
        in: query
        required: false
        schema:
          $ref: '#/components/schemas/v2OrganelleMetadataRequestOrganelleTableFormat'
        examples:
          example-0:
            value: SUMMARY
            summary: This template specifies a basic set of fields available from the organelle report
      - name: include_tabular_header
        description: Specify when to include the table header when requesting a tabular report.
        in: query
        required: false
        schema:
          $ref: '#/components/schemas/v2IncludeTabularHeader'
  /organelle/taxon/{taxons}/dataset_report:
    get:
      summary: Get an organelle data report by taxon
      description: Get an organelle data report  in JSON format.
      tags:
      - Organelle
      operationId: organelle_datareport_by_taxon
      responses:
        default:
          description: An unexpected error response.
          content:
            text/plain:
              schema:
                $ref: '#/components/schemas/rpcStatus'
        '200':
          description: A successful response
          content:
            application/json:
              schema:
                $ref: '#/components/schemas/v2reportsOrganelleDataReports'
            application/x-ndjson:
              schema:
                $ref: '#/components/schemas/v2reportsOrganelleDataReports'
            text/tab-separated-values:
              schema:
                type: string
      parameters:
      - name: taxons
        description: NCBI Taxonomy ID or name (common or scientific) at any taxonomic rank
        in: path
        required: true
        schema:
          type: array
          items:
            type: string
        examples:
          example-0:
            value: '9443'
            summary: Primate organelle genomes
          example-1:
            value:
            - '9606'
            - '10090'
            summary: Human and mouse organelle genomes
      - name: organelle_types
        description: Limit results to the specified organelle types.
        in: query
        required: false
        schema:
          type: array
          items:
            $ref: '#/components/schemas/v2reportsOrganelleType'
      - name: first_release_date
        description: Limit results to organelle genomes released on or after the specified date.
        in: query
        required: false
        schema:
          type: string
          format: date-time
        examples:
          example-0:
            value: '2015-01-10'
            summary: Jan 10, 2015, in ISO 8601 YYYY-MM-DD format
      - name: last_release_date
        description: Limit results to organelle genomes released on or before the specified date.
        in: query
        required: false
        schema:
          type: string
          format: date-time
        examples:
          example-0:
            value: '2021-01-10'
            summary: Jan 10, 2021, in ISO 8601 YYYY-MM-DD format
      - name: tax_exact_match
        description: If true, only return assemblies with the given NCBI Taxonomy ID, or name. Otherwise, assemblies from taxonomy subtree are included, too.
        in: query
        required: false
        schema:
          type: boolean
          default: false
      - name: sort.field
        in: query
        required: false
        schema:
          type: string
      - name: sort.direction
        in: query
        required: false
        schema:
          $ref: '#/components/schemas/v2SortDirection'
      - name: returned_content
        description: Return complete organelle reports or nucleotide accessions only.
        in: query
        required: false
        schema:
          $ref: '#/components/schemas/v2OrganelleMetadataRequestContentType'
        examples:
          example-0:
            value: ASSM_ACC
            summary: Return nucleotide accessions only
      - name: page_size
        description: The maximum number of organelle assemblies to return. Default is 20 and maximum is 1000. If the number of results exceeds the page size, `page_token` can be used to retrieve the remaining results.
        in: query
        required: false
        schema:
          type: integer
      - name: page_token
        description: A page token is returned from an `OrganelleMetadata` call with more than `page_size` results. Use this token, along with the previous `OrganelleMetadata` parameters, to retrieve the next page of results. When `page_token` is empty, all results have been retrieved.
        in: query
        required: false
        schema:
          type: string
      - name: table_format
        description: 'Specify a predefined set of fields for the tabular report using built-in templates. Use of this parameter requires the HTTP header, `accept: text/tab-separated-values`.'
        in: query
        required: false
        schema:
          $ref: '#/components/schemas/v2OrganelleMetadataRequestOrganelleTableFormat'
        examples:
          example-0:
            value: SUMMARY
            summary: This template specifies a basic set of fields available from the organelle report
      - name: include_tabular_header
        description: Specify when to include the table header when requesting a tabular report.
        in: query
        required: false
        schema:
          $ref: '#/components/schemas/v2IncludeTabularHeader'
  /organelle/dataset_report:
    post:
      summary: Get an organelle data report
      description: Get an organelle data report in JSON format.
      tags:
      - Organelle
      operationId: organelle_datareport_by_post
      responses:
        default:
          description: An unexpected error response.
          content:
            text/plain:
              schema:
                $ref: '#/components/schemas/rpcStatus'
        '200':
          description: A successful response
          content:
            application/json:
              schema:
                $ref: '#/components/schemas/v2reportsOrganelleDataReports'
            application/x-ndjson:
              schema:
                $ref: '#/components/schemas/v2reportsOrganelleDataReports'
            text/tab-separated-values:
              schema:
                type: string
      requestBody:
        required: true
        content:
          application/json:
            schema:
              $ref: '#/components/schemas/v2OrganelleMetadataRequest'
            examples:
              Single TaxID example:
                description: Primate organelle genomes
                value:
                  taxons:
                  - '9443'
components:
  schemas:
    v2OrganelleMetadataRequest:
      type: object
      properties:
        taxons:
          type: array
          items:
            type: string
        accessions:
          type: array
          items:
            type: string
        organelle_types:
          type: array
          items:
            $ref: '#/components/schemas/v2reportsOrganelleType'
        first_release_date:
          type: string
          format: date-time
          title: Limit results to organelle genomes released on or after the specified date.
        last_release_date:
          type: string
          format: date-time
          title: Limit results to organelle genomes released on or before the specified date.
        tax_exact_match:
          type: boolean
          title: If true, only return assemblies with the given NCBI Taxonomy ID, or name. Otherwise, assemblies from taxonomy subtree are included, too.
        sort:
          type: array
          items:
            $ref: '#/components/schemas/v2OrganelleSort'
        returned_content:
          $ref: '#/components/schemas/v2OrganelleMetadataRequestContentType'
          title: Return complete organelle reports or nucleotide accessions only.
        page_size:
          type: integer
          title: The maximum number of organelle assemblies to return. Default is 20 and maximum is 1000. If the number of results exceeds the page size, `page_token` can be used to retrieve the remaining results.
        page_token:
          type: string
          title: A page token is returned from an `OrganelleMetadata` call with more than `page_size` results. Use this token, along with the previous `OrganelleMetadata` parameters, to retrieve the next page of results. When `page_token` is empty, all results have been retrieved.
        table_format:
          $ref: '#/components/schemas/v2OrganelleMetadataRequestOrganelleTableFormat'
          title: 'Specify a predefined set of fields for the tabular report using built-in templates. Use of this parameter requires the HTTP header, `accept: text/tab-separated-values`.'
        include_tabular_header:
          $ref: '#/components/schemas/v2IncludeTabularHeader'
          title: Specify when to include the table header when requesting a tabular report.
    v2reportsOrganelleDataReports:
      type: object
      properties:
        messages:
          type: array
          items:
            $ref: '#/components/schemas/v2reportsMessage'
        reports:
          type: array
          items:
            $ref: '#/components/schemas/v2reportsOrganelle'
        total_count:
          type: integer
          title: The total count of available datasets (ignoring the cutoff parameter). Only provided for the first page of results (when `page_token` is empty in the request).
        next_page_token:
          type: string
          title: A token that can be sent as `page_token` to retrieve the next page. If this field is omitted, there are no subsequent pages.
    v2reportsErrorOrganelleErrorCode:
      type: string
      enum:
      - UNKNOWN_ORGANELLE_ERROR_CODE
      - INVALID_ORGANELLE_TAXON
      - NO_ORGANELLES_FOR_ACCESSION
      default: UNKNOWN_ORGANELLE_ERROR_CODE
    v2reportsErrorAssemblyErrorCode:
      type: string
      enum:
      - UNKNOWN_ASSEMBLY_ERROR_CODE
      - INVALID_BIOPROJECT_IDS
      - NO_ASSEMBLIES_FOR_BIOPROJECTS
      - INVALID_TAXON
      - MISSING_SEARCH_FIELD
      - INVALID_BIOSAMPLE_IDS
      - NO_ASSEMBLIES_FOR_BIOSAMPLE_IDS
      - NO_ASSEMBLIES_FOR_ASSEMBLY_NAMES
      - INVALID_WGS_ACCESSIONS
      - NO_ASSEMBLIES_FOR_WGS_ACCESSIONS
      default: UNKNOWN_ASSEMBLY_ERROR_CODE
    v2reportsOrganelleGeneCounts:
      type: object
      properties:
        total:
          type: integer
          title: Total number of annotated genes
        protein_coding:
          type: integer
          title: Count of annotated genes that encode a protein
        rrna:
          type: integer
          title: Count of ribosomal RNAs
        trna:
          type: integer
          title: Count of transfer RNAs
        lncrna:
          type: integer
          title: Count of long, non-coding RNAs
    v2reportsOrganelle:
      type: object
      properties:
        description:
          $ref: '#/components/schemas/v2reportsOrganelleType'
        genbank:
          $ref: '#/components/schemas/v2reportsSequenceInformation'
        refseq:
          $ref: '#/components/schemas/v2reportsSequenceInformation'
        organism:
          $ref: '#/components/schemas/v2reportsOrganism'
          title: Taxon for the organelle
        bioprojects:
          type: array
          items:
            $ref: '#/components/schemas/v2reportsBioProject'
        biosample:
          $ref: '#/components/schemas/v2reportsOrganelleBiosample'
          title: The associated BioSample.
        gene_counts:
          $ref: '#/components/schemas/v2reportsOrganelleGeneCounts'
        length:
          type: integer
          title: Genome length
        topology:
          $ref: '#/components/schemas/v2reportsOrganelleTopology'
        gene_count:
          type: integer
    v2reportsError:
      type: object
      properties:
        assembly_error_code:
          $ref: '#/components/schemas/v2reportsErrorAssemblyErrorCode'
        gene_error_code:
          $ref: '#/components/schemas/v2reportsErrorGeneErrorCode'
        organelle_error_code:
          $ref: '#/components/schemas/v2reportsErrorOrganelleErrorCode'
        virus_error_code:
          $ref: '#/components/schemas/v2reportsErrorVirusErrorCode'
        taxonomy_error_code:
          $ref: '#/components/schemas/v2reportsErrorTaxonomyErrorCode'
        reason:
          type: string
        message:
          type: string
        invalid_identifiers:
          type: array
          items:
            type: string
    v2reportsOrganelleType:
      type: string
      enum:
      - ORGANELLE_TYPE_UNKNOWN
      - Mitochondrion
      - Chloroplast
      - Plastid
      - Kinetoplast
      - Apicoplast
      - Chromatophore
      - Cyanelle
      default: ORGANELLE_TYPE_UNKNOWN
    v2reportsOrganelleTopology:
      type: string
      enum:
      - TOPOLOGY_UNKNOWN
      - Circular
      - Linear
      - Tandem
      default: TOPOLOGY_UNKNOWN
    v2reportsOrganelleBiosample:
      type: object
      properties:
        accession:
          type: string
          title: BioSample Accession identifier
    v2reportsInfraspecificNames:
      type: object
      properties:
        breed:
          type: string
          title: A homogenous group of animals within a domesticated species
        cultivar:
          type: string
          title: A variety of plant within a species produced and maintained by cultivation
        ecotype:
          type: string
          title: A population or subspecies occupying a distinct habitat
        isolate:
          type: string
          title: The individual isolate from which the sequences in the genome assembly were derived
        sex:
          type: string
          title: Physical sex of sampled organism
        strain:
          type: string
          title: A genetic variant, subtype or culture within a species
    v2OrganelleMetadataRequestContentType:
      type: string
      enum:
      - COMPLETE
      - ASSM_ACC
      default: COMPLETE
    v2reportsWarningReplacedId:
      type: object
      properties:
        requested:
          type: string
        returned:
          type: string
    v2reportsErrorVirusErrorCode:
      type: string
      enum:
      - UNKNOWN_VIRUS_ERROR_CODE
      default: UNKNOWN_VIRUS_ERROR_CODE
    v2SortDirection:
      type: string
      enum:
      - SORT_DIRECTION_UNSPECIFIED
      - SORT_DIRECTION_ASCENDING
      - SORT_DIRECTION_DESCENDING
      default: SORT_DIRECTION_UNSPECIFIED
    v2reportsBioProject:
      type: object
      properties:
        accession:
          type: string
          title: BioProject accession
        title:
          type: string
          title: Title of the BioProject provided by the submitter
        parent_accession:
          type: string
        parent_accessions:
          type: array
          items:
            type: string
    v2AnnotationForOrganelleType:
      type: string
      enum:
      - DEFAULT
      - GENOME_FASTA
      - CDS_FASTA
      - PROTEIN_FASTA
      default: DEFAULT
    v2IncludeTabularHeader:
      type: string
      enum:
      - INCLUDE_TABULAR_HEADER_FIRST_PAGE_ONLY
      - INCLUDE_TABULAR_HEADER_ALWAYS
      - INCLUDE_TABULAR_HEADER_NEVER
      default: INCLUDE_TABULAR_HEADER_FIRST_PAGE_ONLY
    v2OrganelleSort:
      type: object
      properties:
        field:
          type: string
        direction:
          $ref: '#/components/schemas/v2SortDirection'
    v2reportsErrorTaxonomyErrorCode:
      type: string
      enum:
      - UNKNOWN_TAXONOMY_ERROR_CODE
      - INVALID_TAXONOMY_TAXON
      default: UNKNOWN_TAXONOMY_ERROR_CODE
    v2reportsLineageOrganism:
      type: object
      properties:
        tax_id:
          type: integer
          title: NCBI Taxonomy identifier
        name:
          type: string
          title: Scientific name
    protobufAny:
      type: object
      properties:
        type_url:
          type: string
        value:
          type: string
          format: byte
    v2reportsSequenceInformation:
      type: object
      properties:
        accession:
          type: string
          title: The accession.version of the organelle genomic nucleotide sequence.
        submission_date:
          type: string
          title: Date record was submitted to GenBank or Curated into RefSeq (ISO 8601)
        submitter:
          type: string
          title: The submitter, e.g. NCBI Genome Project for RefSeq
    v2reportsMessage:
      type: object
      properties:
        error:
          $ref: '#/components/schemas/v2reportsError'
        warning:
          $ref: '#/components/schemas/v2reportsWarning'
    v2reportsErrorGeneErrorCode:
      type: string
      enum:
      - UNKNOWN_GENE_ERROR_CODE
      - INCOMPLETE_LOOKUP_SYMBOL
      - INVALID_TAXON_GENE_ARGUMENT
      default: UNKNOWN_GENE_ERROR_CODE
    v2reportsOrganism:
      type: object
      properties:
        tax_id:
          type: integer
          title: NCBI Taxonomy identifier
        sci_name:
          type: string
          title: Scientific name
        organism_name:
          type: string
          title: Scientific name
        common_name:
          type: string
          title: Common name
        lineage:
          type: array
          items:
            $ref: '#/components/schemas/v2reportsLineageOrganism'
        strain:
          type: string
        pangolin_classification:
          type: string
        infraspecific_names:
          $ref: '#/components/schemas/v2reportsInfraspecificNames'
    v2OrganelleDownloadRequest:
      type: object
      properties:
        accessions:
          type: array
          items:
            type: string
        exclude_sequence:
          type: boolean
          title: If true, exclude the genome sequence from the data package.
        include_annotation_type:
          type: array
          items:
            $ref: '#/components/schemas/v2AnnotationForOrganelleType'
    rpcStatus:
      type: object
      properties:
        code:
          type: integer
          format: int32
        message:
          type: string
        details:
          type: array
          items:
            $ref: '#/components/schemas/protobufAny'
    v2OrganelleMetadataRequestOrganelleTableFormat:
      type: string
      enum:
      - ORGANELLE_TABLE_FORMAT_NO_TABLE
      - SUMMARY
      default: ORGANELLE_TABLE_FORMAT_NO_TABLE
    v2reportsWarningGeneWarningCode:
      type: string
      enum:
      - UNKNOWN_GENE_WARNING_CODE
      - ACCESSION_VERSION_MISMATCH
      - REPLACED_GENE_ID
      - DISCONTINUED_GENE_ID
      - UNRECOGNIZED_GENE_ID
      - UNRECOGNIZED_GENE_SYMBOL
      - UNRECOGNIZED_ACCESSION
      - UNRECOGNIZED_TAX_TOKEN
      - NO_GENE_ANNOTATION_FOUND
      - ABOVE_SPECIES_TAXON
      default: UNKNOWN_GENE_WARNING_CODE
    v2reportsWarning:
      type: object
      properties:
        gene_warning_code:
          $ref: '#/components/schemas/v2reportsWarningGeneWarningCode'
        reason:
          type: string
        message:
          type: string
        replaced_id:
          $ref: '#/components/schemas/v2reportsWarningReplacedId'
        unrecognized_identifier:
          type: string
externalDocs:
  description: Introduction on clinicaltrials.gov
  url: https://clinicaltrials.gov/data-about-studies/learn-about-api