aid: prokarium
name: Prokarium
description: 'Prokarium is a clinical-stage biopharmaceutical company headquartered in London,
  UK, developing bacterial immunotherapies for solid tumors. Its foundational technology uses
  a proprietary attenuated strain of Salmonella enterica serovar Typhi (ZH9) as a microbial
  immunotherapy platform that is naturally tumor-targeting and oncolytic, designed to overcome
  the suppressive tumor microenvironment and generate anti-tumor immune responses while enabling
  diverse cargo delivery. The lead program, ZH9 for non-muscle invasive bladder cancer, is in
  the Phase 1/1b PARADIGM-1 trial, with a muscle-invasive bladder cancer combination arm
  alongside checkpoint inhibitors, an oral immune fitness agent (IO Prime), and a discovery-stage
  Living Cures cargo-delivery platform. Prokarium is a therapeutics developer, not a software
  or data company, and publishes no public API, SDK, developer portal or machine-readable
  interface of any kind.'
url: https://raw.githubusercontent.com/api-evangelist/prokarium/refs/heads/main/apis.yml
x-type: company
x-source: harvest:secondary-market
deliveryModel:
  model: unknown
  open_source: false
  commercial: false
  callable_host: false
  label: Delivery model not determined — needs a product licence on record
  confidence: low
  source:
  - none
  generated: '2026-08-28'
  method: derived
specificationVersion: '0.20'
created: '2026-08-26'
modified: '2026-08-26'
tags:
- Company
- Biotechnology
- Pharmaceuticals
- Life Sciences
- Immunotherapy
- Oncology
- Synthetic Biology
- Clinical Trials
- Healthcare
apis: []
maintainers:
- FN: Kin Lane
  email: kin@apievangelist.com
- FN: APIs.json
  email: info@apis.io
common:
- type: DomainSecurity
  url: security/prokarium-domain-security.yml
- type: Website
  url: https://www.prokarium.com/
- type: PrivacyPolicy
  url: https://www.prokarium.com/privacy
- type: Blog
  url: https://www.prokarium.com/news
x-enrichment:
  date: '2026-08-26'
  status: minimal
  artifacts_added: 2
  pass: local-v1
x-coverage:
  state: none
  reason: not-a-software-company
  detail: >-
    Prokarium is a clinical-stage biopharmaceutical company developing the ZH9 bacterial
    immunotherapy for bladder cancer; its entire 96-URL sitemap is corporate, pipeline and
    press-release pages with no developer, docs, API or data section, and github.com/prokarium
    returns 404, so there is no software product for an API to sit behind.
  evidence:
  - url: https://www.prokarium.com/openapi.json
    status: 404
  - url: https://www.prokarium.com/.well-known/agent-card.json
    status: 404
  - url: https://www.prokarium.com/llms.txt
    status: 404
  - url: https://github.com/prokarium
    status: 404
  - url: https://www.prokarium.com/sitemap.xml
    status: 200
  checked: '2026-08-26'