{
  "$schema": "https://json-schema.org/draft/2020-12/schema",
  "$id": "https://api-evangelist.github.io/regeneron-pharmaceuticals/json-schema/regeneron-drug-target-schema.json",
  "title": "Drug Target",
  "description": "A biological target for drug development identified through Regeneron's genetics and research programs",
  "type": "object",
  "required": ["targetId", "name", "targetType"],
  "properties": {
    "targetId": {
      "type": "string",
      "description": "Unique target identifier"
    },
    "name": {
      "type": "string",
      "description": "Target name (gene symbol or protein name)"
    },
    "targetType": {
      "type": "string",
      "enum": ["Protein", "Gene", "Pathway", "RNA"],
      "description": "Type of biological target"
    },
    "geneSymbol": {
      "type": "string",
      "description": "HGNC approved gene symbol"
    },
    "uniprotId": {
      "type": "string",
      "description": "UniProt accession number for protein targets"
    },
    "biologicalFunction": {
      "type": "string",
      "description": "Description of the target's biological role"
    },
    "diseaseArea": {
      "type": "array",
      "items": { "type": "string" },
      "description": "Disease areas the target is relevant to"
    },
    "modality": {
      "type": "string",
      "enum": ["Antibody", "Small Molecule", "Gene Therapy", "RNA Therapy", "Cell Therapy"],
      "description": "Drug modality applicable to this target"
    },
    "geneticValidation": {
      "type": "boolean",
      "description": "Whether the target has been validated by human genetics evidence"
    },
    "rgcEvidence": {
      "type": "boolean",
      "description": "Whether evidence comes from the Regeneron Genetics Center exome database"
    }
  },
  "additionalProperties": false
}