{
  "opencollection": "1.0.0",
  "info": {
    "name": "STRING REST Enrichment API",
    "version": "12.0"
  },
  "items": [
    {
      "info": {
        "name": "enrichment",
        "type": "folder"
      },
      "items": [
        {
          "info": {
            "name": "Functional Enrichment",
            "type": "http"
          },
          "http": {
            "method": "GET",
            "url": "https://string-db.org/api/:format/enrichment",
            "params": [
              {
                "name": "format",
                "value": "",
                "type": "path",
                "description": "Output format"
              },
              {
                "name": "identifiers",
                "value": "",
                "type": "query",
                "description": "Protein identifiers, newline-separated (%0d in URL)"
              },
              {
                "name": "species",
                "value": "",
                "type": "query",
                "description": "NCBI taxon ID to restrict results to a specific organism. Common values: 9606 (human), 10090 (mouse), 10116 (rat), 7227 (D. melanogaster), 6239 (C. elegans), 4932 (S. cerevisiae), 3702 (A. thaliana), 7955 (zebrafish).\n"
              },
              {
                "name": "background_string_identifiers",
                "value": "",
                "type": "query",
                "description": "Custom background gene set as STRING identifiers for enrichment calculation"
              },
              {
                "name": "allow_pubmed",
                "value": "",
                "type": "query",
                "description": "Include PubMed text mining term enrichment (1=include)"
              },
              {
                "name": "caller_identity",
                "value": "",
                "type": "query",
                "description": "A string identifying your application or organization. Strongly recommended; helps STRING admins contact you if there are issues.\n"
              }
            ]
          },
          "docs": "Perform functional enrichment analysis for a set of proteins. Returns enriched GO terms (biological process, molecular function, cellular component), KEGG pathways, Reactome pathways, Pfam domains, InterPro domains, SMART domains, and tissue/disease annotations.\n"
        },
        {
          "info": {
            "name": "Functional Enrichment (POST)",
            "type": "http"
          },
          "http": {
            "method": "POST",
            "url": "https://string-db.org/api/:format/enrichment",
            "params": [
              {
                "name": "format",
                "value": "",
                "type": "path",
                "description": "Output format"
              }
            ],
            "body": {
              "type": "form-urlencoded",
              "data": [
                {
                  "name": "identifiers",
                  "value": ""
                },
                {
                  "name": "species",
                  "value": ""
                },
                {
                  "name": "background_string_identifiers",
                  "value": ""
                },
                {
                  "name": "allow_pubmed",
                  "value": ""
                },
                {
                  "name": "caller_identity",
                  "value": ""
                }
              ]
            }
          },
          "docs": "Functional Enrichment (POST)"
        },
        {
          "info": {
            "name": "Enrichment Figure",
            "type": "http"
          },
          "http": {
            "method": "GET",
            "url": "https://string-db.org/api/:format/enrichmentfigure",
            "params": [
              {
                "name": "format",
                "value": "",
                "type": "path",
                "description": "Image format"
              },
              {
                "name": "identifiers",
                "value": "",
                "type": "query",
                "description": "Protein identifiers, newline-separated (%0d in URL)"
              },
              {
                "name": "species",
                "value": "",
                "type": "query",
                "description": "NCBI taxon ID to restrict results to a specific organism. Common values: 9606 (human), 10090 (mouse), 10116 (rat), 7227 (D. melanogaster), 6239 (C. elegans), 4932 (S. cerevisiae), 3702 (A. thaliana), 7955 (zebrafish).\n"
              },
              {
                "name": "caller_identity",
                "value": "",
                "type": "query",
                "description": "A string identifying your application or organization. Strongly recommended; helps STRING admins contact you if there are issues.\n"
              }
            ]
          },
          "docs": "Generate a visual figure (image) of enrichment analysis results for a protein set."
        },
        {
          "info": {
            "name": "PPI Enrichment",
            "type": "http"
          },
          "http": {
            "method": "GET",
            "url": "https://string-db.org/api/:format/ppi_enrichment",
            "params": [
              {
                "name": "format",
                "value": "",
                "type": "path",
                "description": "Output format"
              },
              {
                "name": "identifiers",
                "value": "",
                "type": "query",
                "description": "Protein identifiers, newline-separated (%0d in URL)"
              },
              {
                "name": "species",
                "value": "",
                "type": "query",
                "description": "NCBI taxon ID to restrict results to a specific organism. Common values: 9606 (human), 10090 (mouse), 10116 (rat), 7227 (D. melanogaster), 6239 (C. elegans), 4932 (S. cerevisiae), 3702 (A. thaliana), 7955 (zebrafish).\n"
              },
              {
                "name": "required_score",
                "value": "",
                "type": "query",
                "description": "Minimum combined interaction score threshold (0-1000). Higher values return only higher-confidence interactions. Common thresholds: 150 (low), 400 (medium), 700 (high), 900 (highest).\n"
              },
              {
                "name": "network_type",
                "value": "",
                "type": "query",
                "description": "Type of STRING network to use"
              },
              {
                "name": "caller_identity",
                "value": "",
                "type": "query",
                "description": "A string identifying your application or organization. Strongly recommended; helps STRING admins contact you if there are issues.\n"
              }
            ]
          },
          "docs": "Test whether the interactions in a set of proteins are more significant than expected by random chance given the size and connectivity of the proteome. Returns an observed interaction count, expected count, p-value, and average interaction score.\n"
        }
      ]
    }
  ],
  "bundled": true
}