aid: surescripts url: https://raw.githubusercontent.com/api-evangelist/surescripts/refs/heads/main/apis.yml name: Surescripts kind: company description: Surescripts operates the largest health information network in the United States, connecting prescribers, pharmacies, pharmacy benefit managers (PBMs), health plans, and health systems for e-prescribing, medication history, benefit and eligibility verification, electronic prior authorization, and clinical interoperability. Surescripts is a network operator rather than a public API provider - its transaction services run over NCPDP SCRIPT (NewRx, RxRenewal, RxChange, RxTransfer, RxFill, CancelRx), NCPDP Telecommunication, and X12 (270/271 eligibility, 278 prior authorization) standards. There is no self-serve developer portal, no published OpenAPI, and no free API keys; access is gated behind a Surescripts certification process (conformance testing against current NCPDP standards, plus DEA third-party audit for EPCS) or through a certified middleware/EHR partner. The service surfaces below are honestly modeled from Surescripts' published solution descriptions and the underlying NCPDP/X12 transaction standards - endpoints are not publicly documented. image: https://kinlane-images.s3.amazonaws.com/shared/apis-json/apis-json-logo.jpg tags: - Healthcare - E-Prescribing - Health Information Network - NCPDP SCRIPT - Medication History - Prior Authorization - Interoperability - Gated created: '2026-07-04' modified: '2026-07-04' specificationVersion: '0.19' apis: - aid: surescripts:surescripts-e-prescribing-api name: Surescripts E-Prescribing tags: - E-Prescribing - NCPDP SCRIPT - NewRx - CancelRx image: https://kinlane-images.s3.amazonaws.com/shared/apis-json/apis-json-logo.jpg humanURL: https://surescripts.com/what-we-do/e-prescribing endpointsModeled: true properties: - url: https://surescripts.com/what-we-do/e-prescribing type: Documentation description: Routes electronic prescriptions between prescribers and pharmacies over the NCPDP SCRIPT standard, supporting NewRx, RxRenewal, RxChange, RxTransfer, RxFill, CancelRx, and NewRxRequest transactions, plus Electronic Prescribing for Controlled Substances (EPCS). Delivered via certified EHR and pharmacy system integrations, not a public REST endpoint - transactions are modeled from the NCPDP SCRIPT standard. - aid: surescripts:surescripts-medication-history-api name: Surescripts Medication History tags: - Medication History - Medication Reconciliation - NCPDP image: https://kinlane-images.s3.amazonaws.com/shared/apis-json/apis-json-logo.jpg humanURL: https://surescripts.com/what-we-do endpointsModeled: true properties: - url: https://surescripts.com/what-we-do type: Documentation description: Returns a patient's fills and claims-based medication history aggregated across pharmacies and PBMs to support medication reconciliation at the point of care. Exchanged as NCPDP medication history request/response transactions through certified participants - not a publicly documented API surface. - aid: surescripts:surescripts-eligibility-formulary-api name: Surescripts Eligibility and Formulary tags: - Eligibility - Formulary - Benefit - X12 image: https://kinlane-images.s3.amazonaws.com/shared/apis-json/apis-json-logo.jpg humanURL: https://surescripts.com/what-we-do endpointsModeled: true properties: - url: https://surescripts.com/what-we-do type: Documentation description: Verifies patient pharmacy benefit eligibility and returns formulary and benefit coverage details so prescribers see coverage and coverage alternatives in workflow. Modeled on X12 270/271 eligibility exchange and NCPDP formulary and benefit files delivered through the network to certified systems. - aid: surescripts:surescripts-real-time-prescription-benefit-api name: Surescripts Real-Time Prescription Benefit tags: - Real-Time Prescription Benefit - RTPB - Pricing - Cost Transparency image: https://kinlane-images.s3.amazonaws.com/shared/apis-json/apis-json-logo.jpg humanURL: https://surescripts.com/what-we-do endpointsModeled: true properties: - url: https://surescripts.com/what-we-do type: Documentation description: Returns patient-specific, real-time out-of-pocket drug cost, coverage status, and therapeutic alternatives at the point of prescribing. Modeled on the NCPDP Real-Time Prescription Benefit (RTPB) standard and exchanged through certified prescriber systems - no public endpoint or OpenAPI is published. - aid: surescripts:surescripts-electronic-prior-authorization-api name: Surescripts Electronic Prior Authorization tags: - Prior Authorization - ePA - NCPDP SCRIPT image: https://kinlane-images.s3.amazonaws.com/shared/apis-json/apis-json-logo.jpg humanURL: https://surescripts.com/prior-authorization-portal-resources endpointsModeled: true properties: - url: https://surescripts.com/prior-authorization-portal-resources type: Documentation description: Automates electronic prior authorization (ePA) between prescribers and PBMs/payers using the NCPDP SCRIPT ePA transaction set (PAInitiationRequest, PARequest, PAResponse, and related messages). Delivered in-workflow through certified systems; the transaction surface is modeled from the NCPDP SCRIPT ePA standard. - aid: surescripts:surescripts-clinical-direct-messaging-api name: Surescripts Clinical Direct Messaging tags: - Clinical Direct Messaging - Direct Secure Messaging - Interoperability image: https://kinlane-images.s3.amazonaws.com/shared/apis-json/apis-json-logo.jpg humanURL: https://surescripts.com/what-we-do endpointsModeled: true properties: - url: https://surescripts.com/what-we-do type: Documentation description: Provides secure, HIPAA-compliant clinical message exchange (Direct Secure Messaging) for care coordination between providers, including transitions of care and referrals. Delivered over the Direct protocol through certified partners rather than a public REST API. - aid: surescripts:surescripts-record-locator-exchange-api name: Surescripts Record Locator and Exchange tags: - Record Locator - Clinical Data Exchange - Interoperability image: https://kinlane-images.s3.amazonaws.com/shared/apis-json/apis-json-logo.jpg humanURL: https://surescripts.com/what-we-do endpointsModeled: true properties: - url: https://surescripts.com/what-we-do type: Documentation description: Locates where a patient has clinical records across the network and enables retrieval of relevant clinical documents to inform care decisions. Delivered to certified participants through the network; the exchange surface is modeled and not publicly documented as an API. common: - type: DomainSecurity url: security/surescripts-domain-security.yml - type: LinkedIn url: https://www.linkedin.com/company/surescripts - type: Website url: https://surescripts.com - type: Documentation url: https://surescripts.com/what-we-do - type: Certifications url: https://surescripts.com/why-surescripts/certifications-and-accreditations maintainers: - FN: Kin Lane email: kin@apievangelist.com