name: UniProt description: > UniProt is the world's leading high-quality, comprehensive, and freely accessible resource for protein sequence and functional annotation data. Maintained by the UniProt Consortium (EMBL-EBI, SIB, and PIR), it integrates information from experimental literature and computational analysis to provide a single authoritative source on protein function, taxonomy, sequences, cross-references, and disease associations. UniProt exposes a REST API at rest.uniprot.org for searching and retrieving entries from UniProtKB, UniRef, UniParc, Proteomes, and supporting services such as ID mapping. All data is freely available under Creative Commons Attribution 4.0. image: https://www.uniprot.org/images/logos/uniprot.svg url: https://www.uniprot.org/ tags: - Proteins - Bioinformatics - Genomics - Life Sciences - Open Data created: "2002-01-01" modified: "2026-06-13" specificationVersion: "0.19" apis: - name: UniProtKB REST API description: > Search and retrieve protein entries from UniProtKB, which integrates Swiss-Prot (manually reviewed) and TrEMBL (computationally annotated) databases. Supports full-text and field-specific queries, retrieval by accession, and streaming of large result sets. Returns rich protein records including sequences, functional annotations, cross-references, taxonomic lineage, subcellular location, disease associations, and literature citations. image: https://www.uniprot.org/images/logos/uniprot.svg humanURL: https://www.uniprot.org/help/api baseURL: https://rest.uniprot.org/uniprotkb version: "2026_01" tags: - Proteins - Sequences - Annotations - Swiss-Prot - TrEMBL properties: - type: Documentation url: https://www.uniprot.org/help/api - type: OpenAPI url: https://www.uniprot.org/help/api - type: TermsOfService url: https://www.uniprot.org/help/license contact: - FN: UniProt Consortium email: help@uniprot.org url: https://www.uniprot.org/contact - name: UniRef REST API description: > UniRef (UniProt Reference Clusters) groups similar sequences to reduce redundancy. UniRef100 combines identical sequences; UniRef90 clusters sequences sharing 90% identity; UniRef50 clusters at 50%. The REST API allows searching and retrieving clusters with associated member lists. image: https://www.uniprot.org/images/logos/uniprot.svg humanURL: https://www.uniprot.org/help/uniref baseURL: https://rest.uniprot.org/uniref version: "2026_01" tags: - Proteins - Sequence Clusters - Redundancy Reduction properties: - type: Documentation url: https://www.uniprot.org/help/uniref - type: TermsOfService url: https://www.uniprot.org/help/license contact: - FN: UniProt Consortium email: help@uniprot.org url: https://www.uniprot.org/contact - name: UniParc REST API description: > UniParc (UniProt Archive) is a comprehensive non-redundant database of publicly available protein sequences. Each unique sequence appears once with a stable UniParc identifier and cross-references to source databases. The REST API enables retrieval of sequence entries by accession or database cross-reference. image: https://www.uniprot.org/images/logos/uniprot.svg humanURL: https://www.uniprot.org/help/uniparc baseURL: https://rest.uniprot.org/uniparc version: "2026_01" tags: - Proteins - Sequences - Archive properties: - type: Documentation url: https://www.uniprot.org/help/uniparc - type: TermsOfService url: https://www.uniprot.org/help/license contact: - FN: UniProt Consortium email: help@uniprot.org url: https://www.uniprot.org/contact - name: Proteomes REST API description: > Provides access to UniProt proteomes — the complete or near-complete sets of proteins from fully sequenced organisms. Supports retrieval of reference proteomes and gene-centric proteome data. Useful for whole- organism proteomics and comparative genomics workflows. image: https://www.uniprot.org/images/logos/uniprot.svg humanURL: https://www.uniprot.org/help/proteomes baseURL: https://rest.uniprot.org/proteomes version: "2026_01" tags: - Proteomes - Genomics - Comparative Biology properties: - type: Documentation url: https://www.uniprot.org/help/proteomes - type: TermsOfService url: https://www.uniprot.org/help/license contact: - FN: UniProt Consortium email: help@uniprot.org url: https://www.uniprot.org/contact - name: ID Mapping REST API description: > Maps identifiers between UniProt accessions and over 150 external database identifiers (e.g., RefSeq, Ensembl, PDB, ChEMBL, KEGG, OMIM). Asynchronous job-based service: submit a mapping job, poll for completion, then fetch paginated results. Supports bulk conversion of thousands of identifiers in a single request. image: https://www.uniprot.org/images/logos/uniprot.svg humanURL: https://www.uniprot.org/help/id_mapping baseURL: https://rest.uniprot.org/idmapping version: "2026_01" tags: - ID Mapping - Cross-references - Identifiers properties: - type: Documentation url: https://www.uniprot.org/help/id_mapping - type: TermsOfService url: https://www.uniprot.org/help/license contact: - FN: UniProt Consortium email: help@uniprot.org url: https://www.uniprot.org/contact - name: UniProt SPARQL Endpoint description: > A standards-compliant SPARQL 1.1 endpoint exposing the full UniProt knowledge graph as RDF. The current release contains approximately 232 billion triples across 21 named graphs. Supports complex biological queries joining protein sequences, annotations, taxonomy, pathways, and cross-references. Powered by QLever. Query timeout is 45 minutes. image: https://www.uniprot.org/images/logos/uniprot.svg humanURL: https://sparql.uniprot.org/ baseURL: https://sparql.uniprot.org/sparql version: "2026_01" tags: - SPARQL - RDF - Semantic Web - Knowledge Graph properties: - type: Documentation url: https://sparql.uniprot.org/ - type: TermsOfService url: https://www.uniprot.org/help/license contact: - FN: UniProt Consortium email: help@uniprot.org url: https://www.uniprot.org/contact - name: EBI Proteins REST API description: > The EMBL-EBI Proteins API provides integrated access to UniProt protein annotations alongside large-scale study data including variation data from 1000 Genomes, ClinVar, ExAC, COSMIC, gnomAD, and TCGA; proteomics evidence from PeptideAtlas and MaxQB; antigen and epitope annotations; and coordinate mappings. Rate-limited to 200 requests per second per user. image: https://www.uniprot.org/images/logos/uniprot.svg humanURL: https://www.ebi.ac.uk/proteins/api/doc/ baseURL: https://www.ebi.ac.uk/proteins/api version: "1" tags: - Proteins - Variation - Proteomics - Bioinformatics properties: - type: Documentation url: https://www.ebi.ac.uk/proteins/api/doc/ - type: TermsOfService url: https://www.ebi.ac.uk/about/terms-of-use contact: - FN: EMBL-EBI Support url: https://www.ebi.ac.uk/about/contact maintainers: - FN: UniProt Consortium email: help@uniprot.org url: https://www.uniprot.org/contact