{ "cells": [ { "cell_type": "markdown", "metadata": {}, "source": [ "# Problem 2.1: Cost of a steady state\n", "\n", "
" ] }, { "cell_type": "markdown", "metadata": {}, "source": [ "*This problem is still a draft.*\n", "\n", "We worked out that for unregulated gene expression, the steady state level of gene product is $\\beta/\\gamma$, where $\\beta$ is the production rate and $\\gamma$ is the degradation rate. A steady state may be achieved for low $\\beta$ and low $\\gamma$, for high $\\beta$ and high $\\gamma$, and everything in between, provided the ratio $\\beta/\\gamma$ is the same.\n", "\n", "A **loss function**, also known as a **cost function**, takes as input an operating parameter or set of parameters and returns the \"cost\" associated operating with the given parameter value(s). Sketch a loss function $L(\\beta)$ as a function of $\\beta$, assuming $\\beta/\\gamma$ is held constant. Describe why the curve might have the shape it does. Note that there is no right answer, or even a quantitative one, for this problem. It is meant to get you thinking about what some of the costs may be that are associated with different operating regimes." ] }, { "cell_type": "markdown", "metadata": {}, "source": [ "
" ] } ], "metadata": { "anaconda-cloud": {}, "kernelspec": { "display_name": "Python 3", "language": "python", "name": "python3" }, "language_info": { "codemirror_mode": { "name": "ipython", "version": 3 }, "file_extension": ".py", "mimetype": "text/x-python", "name": "python", "nbconvert_exporter": "python", "pygments_lexer": "ipython3", "version": "3.8.8" } }, "nbformat": 4, "nbformat_minor": 4 }