{ "cells": [ { "cell_type": "markdown", "metadata": {}, "source": [ "# Problem 3.7: Design principles for toggles\n", "\n", "
\n" ] }, { "cell_type": "markdown", "metadata": {}, "source": [ "Consider two components, A and B, which regulate each other. A may activate or repress B, and B may activate or repress A. There are three possible architectures in this scenario, two with positive feedback and one with negative feedback, shown below.\n", "\n", "
\n", "\n", "![Toggles](toggles.png)\n", " \n", "
\n", "\n", "
\n", "\n", "**a)** A circuit can behave like a toggle if it has two stable steady states, one with A high and B low and another with B high and A low. Only one of the above architectures can function as a toggle. Which one? Explain in words and sketches why _only_ the one you chose can be a toggle.\n", "\n", "**b)** A and/or B may have ultrasensitive regulation, which we describe with a Hill coefficient, $n$, greater than one. Show that without ultrasensitive regulation, even the architecture you chose cannot have toggle behavior." ] }, { "cell_type": "markdown", "metadata": {}, "source": [ "
" ] } ], "metadata": { "anaconda-cloud": {}, "kernelspec": { "display_name": "Python 3 (ipykernel)", "language": "python", "name": "python3" }, "language_info": { "codemirror_mode": { "name": "ipython", "version": 3 }, "file_extension": ".py", "mimetype": "text/x-python", "name": "python", "nbconvert_exporter": "python", "pygments_lexer": "ipython3", "version": "3.9.7" } }, "nbformat": 4, "nbformat_minor": 4 }