GO.ID	Description	p.Val	FDR	Phenotype	Genes
GO:0060255	regulation of macromolecule metabolic process	6.67926478986947e-33	6.67926478986947e-33	+1	TP53,PTEN,APC,VHL,KRAS,ARID1A,EGFR,NF1,PIK3R1,CDKN2A,GATA3,RB1,NOTCH1,FBXW7,CTNNB1,DNMT3A,MAP3K1,FLT3,TSHZ3,KEAP1,CDH1,ARHGAP35,CTCF,NFE2L2,NPM1,RUNX1,TBX3,MAP2K4,STK11,CRIPAK,CEBPA,AKT1,STAG2,BRAF,AR,AJUBA,TSHZ2,PIK3CG,SOX9,ATM,CDKN1B,WT1,HGF,KDM5C,PRX,ERBB4,MTOR,TLR4,ARID5B,TET2,ATRX,ELF3,BRCA1,LRRK2,POLQ,FOXA1,CHEK2,KIT,HIST1H1C,SETD2,PDGFRA,EP300,FGFR2,CCND1,SMAD4,FOXA2,USP9X,BRCA2,NFE2L3,FGFR3,ASXL1,TGFBR2,SOX17,CDKN1A,SF3B1,TAF1,PPP2R1A,CBFB,ATR,SIN3A,VEZF1,EIF4A2,CDK12,PHF6,SMC1A,PTPN11,ACVR1B,MAPK8IP1,NSD1,TBL1XR1,EGR3,ACVR2A,MECOM,SMC3,NCOR1,RPL5,SMAD2,SPOP,AXIN2,RAD21,ERCC2,CDKN2C,EZH2
GO:0031323	regulation of cellular metabolic process	6.67926478986947e-33	6.67926478986947e-33	+1	TP53,PIK3CA,PTEN,APC,VHL,KRAS,ARID1A,EGFR,NF1,PIK3R1,CDKN2A,GATA3,RB1,NOTCH1,FBXW7,CTNNB1,DNMT3A,MAP3K1,FLT3,TSHZ3,KEAP1,CDH1,ARHGAP35,CTCF,NFE2L2,NPM1,RUNX1,IDH1,TBX3,MAP2K4,STK11,CRIPAK,CEBPA,AKT1,STAG2,BRAF,AR,TSHZ2,PIK3CG,SOX9,ATM,CDKN1B,WT1,HGF,KDM5C,PRX,ERBB4,MTOR,TLR4,ARID5B,TET2,ATRX,ELF3,BRCA1,LRRK2,POLQ,FOXA1,CHEK2,KIT,HIST1H1C,SETD2,PDGFRA,EP300,FGFR2,CCND1,SMAD4,FOXA2,USP9X,BRCA2,NFE2L3,FGFR3,ASXL1,TGFBR2,SOX17,CDKN1A,TAF1,PPP2R1A,CBFB,ATR,SIN3A,VEZF1,EIF4A2,CDK12,PHF6,SMC1A,PTPN11,ACVR1B,MAPK8IP1,NSD1,TBL1XR1,EGR3,ACVR2A,MECOM,SMC3,NCOR1,RPL5,SMAD2,AXIN2,RAD21,ERCC2,CDKN2C,EZH2
GO:0019222	regulation of metabolic process	1.1248634000991487e-31	1.1248634000991487e-31	+1	TP53,PIK3CA,PTEN,APC,VHL,KRAS,ARID1A,EGFR,NF1,PIK3R1,CDKN2A,GATA3,RB1,NOTCH1,FBXW7,CTNNB1,DNMT3A,MAP3K1,FLT3,TSHZ3,KEAP1,CDH1,ARHGAP35,CTCF,NFE2L2,NPM1,RUNX1,IDH1,TBX3,MAP2K4,STK11,CRIPAK,CEBPA,AKT1,STAG2,BRAF,AR,AJUBA,TSHZ2,PIK3CG,SOX9,ATM,CDKN1B,WT1,HGF,KDM5C,PRX,ERBB4,MTOR,TLR4,ARID5B,TET2,ATRX,ELF3,BRCA1,LRRK2,POLQ,FOXA1,CHEK2,KIT,HIST1H1C,SETD2,PDGFRA,EP300,FGFR2,CCND1,SMAD4,FOXA2,USP9X,BRCA2,NFE2L3,FGFR3,ASXL1,TGFBR2,SOX17,CDKN1A,SF3B1,TAF1,PPP2R1A,CBFB,ATR,SIN3A,VEZF1,EIF4A2,CDK12,PHF6,SMC1A,PTPN11,ACVR1B,MAPK8IP1,NSD1,TBL1XR1,EGR3,ACVR2A,MECOM,SMC3,NCOR1,RPL5,SMAD2,SPOP,AXIN2,RAD21,ERCC2,CDKN2C,EZH2
GO:0051171	regulation of nitrogen compound metabolic process	1.1248634000991487e-31	1.1248634000991487e-31	+1	TP53,PTEN,APC,VHL,KRAS,ARID1A,EGFR,NF1,PIK3R1,CDKN2A,GATA3,RB1,NOTCH1,FBXW7,CTNNB1,DNMT3A,MAP3K1,FLT3,TSHZ3,KEAP1,CDH1,ARHGAP35,CTCF,NFE2L2,NPM1,RUNX1,TBX3,MAP2K4,STK11,CRIPAK,CEBPA,AKT1,BRAF,AR,TSHZ2,PIK3CG,SOX9,ATM,CDKN1B,WT1,HGF,KDM5C,PRX,ERBB4,MTOR,TLR4,ARID5B,TET2,ATRX,ELF3,BRCA1,LRRK2,POLQ,FOXA1,CHEK2,KIT,HIST1H1C,SETD2,PDGFRA,EP300,FGFR2,CCND1,SMAD4,FOXA2,USP9X,BRCA2,NFE2L3,FGFR3,ASXL1,TGFBR2,SOX17,CDKN1A,TAF1,PPP2R1A,CBFB,ATR,SIN3A,VEZF1,EIF4A2,CDK12,PHF6,PTPN11,ACVR1B,MAPK8IP1,NSD1,TBL1XR1,EGR3,ACVR2A,MECOM,NCOR1,RPL5,SMAD2,SPOP,AXIN2,RAD21,ERCC2,CDKN2C,EZH2
GO:0080090	regulation of primary metabolic process	1.3866724712215681e-31	1.3866724712215681e-31	+1	TP53,PTEN,APC,VHL,KRAS,ARID1A,EGFR,NF1,PIK3R1,CDKN2A,GATA3,RB1,NOTCH1,FBXW7,CTNNB1,DNMT3A,MAP3K1,FLT3,TSHZ3,KEAP1,CDH1,ARHGAP35,CTCF,NFE2L2,NPM1,RUNX1,IDH1,TBX3,MAP2K4,STK11,CRIPAK,CEBPA,AKT1,BRAF,AR,TSHZ2,PIK3CG,SOX9,ATM,CDKN1B,WT1,HGF,KDM5C,PRX,ERBB4,MTOR,TLR4,ARID5B,TET2,ATRX,ELF3,BRCA1,LRRK2,POLQ,FOXA1,CHEK2,KIT,HIST1H1C,SETD2,PDGFRA,EP300,FGFR2,CCND1,SMAD4,FOXA2,USP9X,BRCA2,NFE2L3,FGFR3,ASXL1,TGFBR2,SOX17,CDKN1A,TAF1,PPP2R1A,CBFB,ATR,SIN3A,VEZF1,EIF4A2,CDK12,PHF6,PTPN11,ACVR1B,MAPK8IP1,NSD1,TBL1XR1,EGR3,ACVR2A,MECOM,NCOR1,RPL5,SMAD2,SPOP,AXIN2,RAD21,ERCC2,CDKN2C,EZH2
GO:0051173	positive regulation of nitrogen compound metabolic process	7.222568101693138e-29	7.222568101693138e-29	+1	TP53,PTEN,APC,VHL,KRAS,ARID1A,EGFR,PIK3R1,CDKN2A,GATA3,RB1,NOTCH1,FBXW7,CTNNB1,MAP3K1,FLT3,KEAP1,CDH1,CTCF,NFE2L2,NPM1,RUNX1,MAP2K4,STK11,CEBPA,AKT1,BRAF,AR,PIK3CG,SOX9,ATM,CDKN1B,WT1,HGF,ERBB4,MTOR,TLR4,TET2,ATRX,ELF3,BRCA1,LRRK2,FOXA1,CHEK2,KIT,HIST1H1C,PDGFRA,EP300,FGFR2,CCND1,SMAD4,FOXA2,USP9X,BRCA2,NFE2L3,FGFR3,ASXL1,TGFBR2,SOX17,CDKN1A,TAF1,ATR,SIN3A,VEZF1,CDK12,PTPN11,MAPK8IP1,NSD1,TBL1XR1,EGR3,ACVR2A,MECOM,RPL5,SMAD2,AXIN2,ERCC2,EZH2
GO:0010604	positive regulation of macromolecule metabolic process	7.222568101693138e-29	7.222568101693138e-29	+1	TP53,PTEN,APC,VHL,KRAS,ARID1A,EGFR,PIK3R1,CDKN2A,GATA3,RB1,NOTCH1,FBXW7,CTNNB1,MAP3K1,FLT3,KEAP1,CDH1,CTCF,NFE2L2,NPM1,RUNX1,MAP2K4,STK11,CEBPA,AKT1,BRAF,AR,PIK3CG,SOX9,ATM,CDKN1B,WT1,HGF,ERBB4,MTOR,TLR4,TET2,ATRX,ELF3,BRCA1,LRRK2,FOXA1,CHEK2,KIT,HIST1H1C,PDGFRA,EP300,FGFR2,CCND1,SMAD4,FOXA2,USP9X,BRCA2,NFE2L3,FGFR3,ASXL1,TGFBR2,SOX17,CDKN1A,SF3B1,TAF1,ATR,SIN3A,VEZF1,CDK12,PTPN11,MAPK8IP1,NSD1,TBL1XR1,EGR3,ACVR2A,MECOM,NCOR1,RPL5,SMAD2,AXIN2,ERCC2,EZH2
GO:2000112	regulation of cellular macromolecule biosynthetic process	3.8646583932793317e-28	3.8646583932793317e-28	+1	TP53,PTEN,VHL,ARID1A,EGFR,PIK3R1,CDKN2A,GATA3,RB1,NOTCH1,FBXW7,CTNNB1,DNMT3A,TSHZ3,KEAP1,CDH1,ARHGAP35,CTCF,NFE2L2,NPM1,RUNX1,TBX3,CEBPA,AKT1,STAG2,AR,TSHZ2,SOX9,ATM,CDKN1B,WT1,HGF,KDM5C,ERBB4,MTOR,TLR4,ARID5B,TET2,ATRX,ELF3,BRCA1,FOXA1,CHEK2,KIT,HIST1H1C,EP300,FGFR2,CCND1,SMAD4,FOXA2,USP9X,BRCA2,NFE2L3,ASXL1,SOX17,CDKN1A,TAF1,PPP2R1A,CBFB,ATR,SIN3A,VEZF1,EIF4A2,CDK12,PHF6,SMC1A,ACVR1B,NSD1,TBL1XR1,EGR3,ACVR2A,MECOM,SMC3,NCOR1,RPL5,SMAD2,RAD21,ERCC2,EZH2
GO:1903506	regulation of nucleic acid-templated transcription	4.707497175553479e-28	4.707497175553479e-28	+1	TP53,PTEN,VHL,ARID1A,EGFR,PIK3R1,CDKN2A,GATA3,RB1,NOTCH1,FBXW7,CTNNB1,DNMT3A,TSHZ3,KEAP1,CDH1,ARHGAP35,CTCF,NFE2L2,NPM1,RUNX1,TBX3,CEBPA,AKT1,AR,TSHZ2,SOX9,ATM,CDKN1B,WT1,HGF,KDM5C,ERBB4,MTOR,TLR4,ARID5B,TET2,ATRX,ELF3,BRCA1,FOXA1,CHEK2,KIT,HIST1H1C,EP300,FGFR2,CCND1,SMAD4,FOXA2,USP9X,BRCA2,NFE2L3,ASXL1,SOX17,CDKN1A,TAF1,PPP2R1A,CBFB,SIN3A,VEZF1,EIF4A2,CDK12,PHF6,ACVR1B,NSD1,TBL1XR1,EGR3,ACVR2A,MECOM,NCOR1,SMAD2,RAD21,ERCC2,EZH2
GO:2001141	regulation of RNA biosynthetic process	5.290885839437953e-28	5.290885839437953e-28	+1	TP53,PTEN,VHL,ARID1A,EGFR,PIK3R1,CDKN2A,GATA3,RB1,NOTCH1,FBXW7,CTNNB1,DNMT3A,TSHZ3,KEAP1,CDH1,ARHGAP35,CTCF,NFE2L2,NPM1,RUNX1,TBX3,CEBPA,AKT1,AR,TSHZ2,SOX9,ATM,CDKN1B,WT1,HGF,KDM5C,ERBB4,MTOR,TLR4,ARID5B,TET2,ATRX,ELF3,BRCA1,FOXA1,CHEK2,KIT,HIST1H1C,EP300,FGFR2,CCND1,SMAD4,FOXA2,USP9X,BRCA2,NFE2L3,ASXL1,SOX17,CDKN1A,TAF1,PPP2R1A,CBFB,SIN3A,VEZF1,EIF4A2,CDK12,PHF6,ACVR1B,NSD1,TBL1XR1,EGR3,ACVR2A,MECOM,NCOR1,SMAD2,RAD21,ERCC2,EZH2
GO:0019219	regulation of nucleobase-containing compound metabolic process	8.71996749997552e-28	8.71996749997552e-28	+1	TP53,PTEN,VHL,ARID1A,EGFR,PIK3R1,CDKN2A,GATA3,RB1,NOTCH1,FBXW7,CTNNB1,DNMT3A,TSHZ3,KEAP1,CDH1,ARHGAP35,CTCF,NFE2L2,NPM1,RUNX1,TBX3,CEBPA,AKT1,AR,TSHZ2,SOX9,ATM,CDKN1B,WT1,HGF,KDM5C,PRX,ERBB4,MTOR,TLR4,ARID5B,TET2,ATRX,ELF3,BRCA1,POLQ,FOXA1,CHEK2,KIT,HIST1H1C,SETD2,EP300,FGFR2,CCND1,SMAD4,FOXA2,USP9X,BRCA2,NFE2L3,ASXL1,SOX17,CDKN1A,TAF1,PPP2R1A,CBFB,ATR,SIN3A,VEZF1,EIF4A2,CDK12,PHF6,ACVR1B,NSD1,TBL1XR1,EGR3,ACVR2A,MECOM,NCOR1,SMAD2,AXIN2,RAD21,ERCC2,EZH2
GO:0097659	nucleic acid-templated transcription	8.71996749997552e-28	8.71996749997552e-28	+1	TP53,PTEN,VHL,ARID1A,PBRM1,EGFR,PIK3R1,CDKN2A,GATA3,RB1,NOTCH1,FBXW7,CTNNB1,DNMT3A,TSHZ3,KEAP1,CDH1,ARHGAP35,CTCF,NFE2L2,NPM1,RUNX1,TBX3,CEBPA,AKT1,AR,TSHZ2,SOX9,ATM,CDKN1B,WT1,HGF,KDM5C,ERBB4,MTOR,TLR4,ARID5B,TET2,ATRX,ELF3,BRCA1,FOXA1,CHEK2,KIT,HIST1H1C,SETD2,EP300,FGFR2,CCND1,SMAD4,FOXA2,USP9X,BRCA2,NFE2L3,ASXL1,SOX17,CDKN1A,TAF1,PPP2R1A,CBFB,SIN3A,VEZF1,EIF4A2,CDK12,PHF6,ACVR1B,NSD1,TBL1XR1,EGR3,ACVR2A,MECOM,NCOR1,SMAD2,RAD21,ERCC2,EZH2
GO:0032774	RNA biosynthetic process	1.0197377122402628e-27	1.0197377122402628e-27	+1	TP53,PTEN,VHL,ARID1A,PBRM1,EGFR,PIK3R1,CDKN2A,GATA3,RB1,NOTCH1,FBXW7,CTNNB1,DNMT3A,TSHZ3,KEAP1,CDH1,ARHGAP35,CTCF,NFE2L2,NPM1,RUNX1,TBX3,CEBPA,AKT1,AR,TSHZ2,SOX9,ATM,CDKN1B,WT1,HGF,KDM5C,ERBB4,MTOR,TLR4,ARID5B,TET2,ATRX,ELF3,BRCA1,FOXA1,CHEK2,KIT,HIST1H1C,SETD2,EP300,FGFR2,CCND1,SMAD4,FOXA2,USP9X,BRCA2,NFE2L3,ASXL1,SOX17,CDKN1A,TAF1,PPP2R1A,CBFB,SIN3A,VEZF1,EIF4A2,CDK12,PHF6,ACVR1B,NSD1,TBL1XR1,EGR3,ACVR2A,MECOM,NCOR1,SMAD2,RAD21,ERCC2,EZH2
GO:0010556	regulation of macromolecule biosynthetic process	1.071802506274188e-27	1.071802506274188e-27	+1	TP53,PTEN,VHL,ARID1A,EGFR,PIK3R1,CDKN2A,GATA3,RB1,NOTCH1,FBXW7,CTNNB1,DNMT3A,TSHZ3,KEAP1,CDH1,ARHGAP35,CTCF,NFE2L2,NPM1,RUNX1,TBX3,CEBPA,AKT1,STAG2,AR,TSHZ2,SOX9,ATM,CDKN1B,WT1,HGF,KDM5C,ERBB4,MTOR,TLR4,ARID5B,TET2,ATRX,ELF3,BRCA1,FOXA1,CHEK2,KIT,HIST1H1C,EP300,FGFR2,CCND1,SMAD4,FOXA2,USP9X,BRCA2,NFE2L3,ASXL1,SOX17,CDKN1A,TAF1,PPP2R1A,CBFB,ATR,SIN3A,VEZF1,EIF4A2,CDK12,PHF6,SMC1A,ACVR1B,NSD1,TBL1XR1,EGR3,ACVR2A,MECOM,SMC3,NCOR1,RPL5,SMAD2,RAD21,ERCC2,EZH2
GO:0031326	regulation of cellular biosynthetic process	1.1256261873565582e-27	1.1256261873565582e-27	+1	TP53,PTEN,VHL,ARID1A,EGFR,PIK3R1,CDKN2A,GATA3,RB1,NOTCH1,FBXW7,CTNNB1,DNMT3A,TSHZ3,KEAP1,CDH1,ARHGAP35,CTCF,NFE2L2,NPM1,RUNX1,IDH1,TBX3,CEBPA,AKT1,STAG2,AR,TSHZ2,SOX9,ATM,CDKN1B,WT1,HGF,KDM5C,ERBB4,MTOR,TLR4,ARID5B,TET2,ATRX,ELF3,BRCA1,FOXA1,CHEK2,KIT,HIST1H1C,EP300,FGFR2,CCND1,SMAD4,FOXA2,USP9X,BRCA2,NFE2L3,ASXL1,SOX17,CDKN1A,TAF1,PPP2R1A,CBFB,ATR,SIN3A,VEZF1,EIF4A2,CDK12,PHF6,SMC1A,ACVR1B,NSD1,TBL1XR1,EGR3,ACVR2A,MECOM,SMC3,NCOR1,RPL5,SMAD2,RAD21,ERCC2,EZH2
GO:0006355	regulation of transcription, DNA-templated	1.990502877770566e-27	1.990502877770566e-27	+1	TP53,PTEN,VHL,ARID1A,EGFR,PIK3R1,CDKN2A,GATA3,RB1,NOTCH1,FBXW7,CTNNB1,DNMT3A,TSHZ3,KEAP1,CDH1,ARHGAP35,CTCF,NFE2L2,NPM1,RUNX1,TBX3,CEBPA,AKT1,AR,TSHZ2,SOX9,ATM,CDKN1B,WT1,HGF,KDM5C,ERBB4,MTOR,TLR4,ARID5B,TET2,ATRX,ELF3,BRCA1,FOXA1,CHEK2,KIT,HIST1H1C,EP300,FGFR2,CCND1,SMAD4,FOXA2,USP9X,BRCA2,NFE2L3,ASXL1,SOX17,CDKN1A,TAF1,PPP2R1A,CBFB,SIN3A,VEZF1,CDK12,PHF6,ACVR1B,NSD1,TBL1XR1,EGR3,ACVR2A,MECOM,NCOR1,SMAD2,RAD21,ERCC2,EZH2
GO:0051252	regulation of RNA metabolic process	2.710057758954242e-27	2.710057758954242e-27	+1	TP53,PTEN,VHL,ARID1A,EGFR,PIK3R1,CDKN2A,GATA3,RB1,NOTCH1,FBXW7,CTNNB1,DNMT3A,TSHZ3,KEAP1,CDH1,ARHGAP35,CTCF,NFE2L2,NPM1,RUNX1,TBX3,CEBPA,AKT1,AR,TSHZ2,SOX9,ATM,CDKN1B,WT1,HGF,KDM5C,PRX,ERBB4,MTOR,TLR4,ARID5B,TET2,ATRX,ELF3,BRCA1,FOXA1,CHEK2,KIT,HIST1H1C,EP300,FGFR2,CCND1,SMAD4,FOXA2,USP9X,BRCA2,NFE2L3,ASXL1,SOX17,CDKN1A,TAF1,PPP2R1A,CBFB,SIN3A,VEZF1,EIF4A2,CDK12,PHF6,ACVR1B,NSD1,TBL1XR1,EGR3,ACVR2A,MECOM,NCOR1,SMAD2,AXIN2,RAD21,ERCC2,EZH2
GO:0009889	regulation of biosynthetic process	3.7705222557006706e-27	3.7705222557006706e-27	+1	TP53,PTEN,VHL,ARID1A,EGFR,PIK3R1,CDKN2A,GATA3,RB1,NOTCH1,FBXW7,CTNNB1,DNMT3A,TSHZ3,KEAP1,CDH1,ARHGAP35,CTCF,NFE2L2,NPM1,RUNX1,IDH1,TBX3,CEBPA,AKT1,STAG2,AR,TSHZ2,SOX9,ATM,CDKN1B,WT1,HGF,KDM5C,ERBB4,MTOR,TLR4,ARID5B,TET2,ATRX,ELF3,BRCA1,FOXA1,CHEK2,KIT,HIST1H1C,EP300,FGFR2,CCND1,SMAD4,FOXA2,USP9X,BRCA2,NFE2L3,ASXL1,SOX17,CDKN1A,TAF1,PPP2R1A,CBFB,ATR,SIN3A,VEZF1,EIF4A2,CDK12,PHF6,SMC1A,ACVR1B,NSD1,TBL1XR1,EGR3,ACVR2A,MECOM,SMC3,NCOR1,RPL5,SMAD2,RAD21,ERCC2,EZH2
GO:0006351	transcription, DNA-templated	4.076701129208682e-27	4.076701129208682e-27	+1	TP53,PTEN,VHL,ARID1A,PBRM1,EGFR,PIK3R1,CDKN2A,GATA3,RB1,NOTCH1,FBXW7,CTNNB1,DNMT3A,TSHZ3,KEAP1,CDH1,ARHGAP35,CTCF,NFE2L2,NPM1,RUNX1,TBX3,CEBPA,AKT1,AR,TSHZ2,SOX9,ATM,CDKN1B,WT1,HGF,KDM5C,ERBB4,MTOR,TLR4,ARID5B,TET2,ATRX,ELF3,BRCA1,FOXA1,CHEK2,KIT,HIST1H1C,SETD2,EP300,FGFR2,CCND1,SMAD4,FOXA2,USP9X,BRCA2,NFE2L3,ASXL1,SOX17,CDKN1A,TAF1,PPP2R1A,CBFB,SIN3A,VEZF1,CDK12,PHF6,ACVR1B,NSD1,TBL1XR1,EGR3,ACVR2A,MECOM,NCOR1,SMAD2,RAD21,ERCC2,EZH2
GO:0009893	positive regulation of metabolic process	7.532171112640536e-27	7.532171112640536e-27	+1	TP53,PTEN,APC,VHL,KRAS,ARID1A,EGFR,PIK3R1,CDKN2A,GATA3,RB1,NOTCH1,FBXW7,CTNNB1,MAP3K1,FLT3,KEAP1,CDH1,CTCF,NFE2L2,NPM1,RUNX1,MAP2K4,STK11,CEBPA,AKT1,BRAF,AR,PIK3CG,SOX9,ATM,CDKN1B,WT1,HGF,ERBB4,MTOR,TLR4,TET2,ATRX,ELF3,BRCA1,LRRK2,FOXA1,CHEK2,KIT,HIST1H1C,PDGFRA,EP300,FGFR2,CCND1,SMAD4,FOXA2,USP9X,BRCA2,NFE2L3,FGFR3,ASXL1,TGFBR2,SOX17,CDKN1A,SF3B1,TAF1,ATR,SIN3A,VEZF1,CDK12,PTPN11,MAPK8IP1,NSD1,TBL1XR1,EGR3,ACVR2A,MECOM,NCOR1,RPL5,SMAD2,AXIN2,ERCC2,EZH2
GO:0031324	negative regulation of cellular metabolic process	7.583544801846603e-27	7.583544801846603e-27	+1	TP53,PIK3CA,PTEN,APC,VHL,NF1,CDKN2A,GATA3,RB1,NOTCH1,FBXW7,CTNNB1,DNMT3A,TSHZ3,ARHGAP35,CTCF,NPM1,RUNX1,TBX3,CRIPAK,CEBPA,AKT1,STAG2,AR,SOX9,ATM,CDKN1B,WT1,HGF,KDM5C,MTOR,TLR4,ARID5B,ATRX,ELF3,BRCA1,LRRK2,POLQ,CHEK2,HIST1H1C,EP300,FGFR2,CCND1,SMAD4,FOXA2,USP9X,SOX17,CDKN1A,TAF1,PPP2R1A,CBFB,ATR,SIN3A,EIF4A2,PHF6,SMC1A,MAPK8IP1,NSD1,TBL1XR1,MECOM,SMC3,NCOR1,RPL5,SMAD2,AXIN2,CDKN2C,EZH2
GO:0048522	positive regulation of cellular process	1.1603990226511496e-26	1.1603990226511496e-26	+1	TP53,PIK3CA,PTEN,APC,VHL,KRAS,ARID1A,NAV3,EGFR,NF1,PIK3R1,CDKN2A,GATA3,RB1,NOTCH1,FBXW7,CTNNB1,MAP3K1,FLT3,TSHZ3,KEAP1,CDH1,ARHGAP35,CTCF,NFE2L2,BAP1,NPM1,RUNX1,NRAS,TBX3,MAP2K4,STK11,CEBPA,EPHA3,AKT1,BRAF,AR,AJUBA,PIK3CG,SOX9,ATM,CDKN1B,WT1,HGF,ERBB4,MTOR,TLR4,TET2,ATRX,ELF3,BRCA1,LRRK2,FOXA1,CHEK2,KIT,HIST1H1C,PDGFRA,EP300,FGFR2,CCND1,SMAD4,FOXA2,USP9X,BRCA2,NFE2L3,FGFR3,ASXL1,TGFBR2,SOX17,CDKN1A,TAF1,CBFB,ATR,SIN3A,VEZF1,CDK12,PTPN11,ACVR1B,MAPK8IP1,H3F3C,NSD1,TBL1XR1,EGR3,ACVR2A,MECOM,LIFR,RPL5,SMAD2,AXIN2,MIR142,RAD21,ERCC2,EZH2
GO:0010468	regulation of gene expression	2.5123236679996682e-26	2.5123236679996682e-26	+1	TP53,PTEN,VHL,KRAS,ARID1A,EGFR,PIK3R1,CDKN2A,GATA3,RB1,NOTCH1,FBXW7,CTNNB1,DNMT3A,TSHZ3,KEAP1,CDH1,ARHGAP35,CTCF,NFE2L2,NPM1,RUNX1,TBX3,CEBPA,AKT1,BRAF,AR,AJUBA,TSHZ2,SOX9,ATM,CDKN1B,WT1,HGF,KDM5C,PRX,ERBB4,MTOR,TLR4,ARID5B,TET2,ATRX,ELF3,BRCA1,LRRK2,FOXA1,CHEK2,KIT,HIST1H1C,SETD2,EP300,FGFR2,CCND1,SMAD4,FOXA2,USP9X,BRCA2,NFE2L3,ASXL1,SOX17,CDKN1A,SF3B1,TAF1,PPP2R1A,CBFB,SIN3A,VEZF1,EIF4A2,CDK12,PHF6,ACVR1B,NSD1,TBL1XR1,EGR3,ACVR2A,MECOM,NCOR1,RPL5,SMAD2,AXIN2,RAD21,ERCC2,EZH2
GO:0048523	negative regulation of cellular process	2.86398306603962e-26	2.86398306603962e-26	+1	TP53,PIK3CA,PTEN,APC,VHL,PBRM1,NAV3,EGFR,NF1,PIK3R1,CDKN2A,GATA3,RB1,NOTCH1,FBXW7,CTNNB1,DNMT3A,TSHZ3,CDH1,ARHGAP35,CTCF,NFE2L2,BAP1,NPM1,RUNX1,TBX3,STK11,CRIPAK,CEBPA,EPHA3,AKT1,STAG2,BRAF,AR,AJUBA,EPPK1,SOX9,ATM,CDKN1B,WT1,HGF,KDM5C,ERBB4,MTOR,TLR4,ARID5B,ATRX,ELF3,BRCA1,LRRK2,POLQ,FOXA1,CHEK2,HIST1H1C,PDGFRA,EP300,FGFR2,CCND1,SMAD4,FOXA2,USP9X,BRCA2,ASXL1,TGFBR2,SOX17,CDKN1A,TAF1,PPP2R1A,CBFB,ATR,SIN3A,EIF4A2,PHF6,SMC1A,ACVR1B,MAPK8IP1,NSD1,TBL1XR1,EGR3,MECOM,SMC3,NCOR1,RPL5,SMAD2,AXIN2,CDKN2C,EZH2
GO:0006366	transcription by RNA polymerase II	3.162638807382091e-26	3.162638807382091e-26	+1	TP53,PTEN,VHL,ARID1A,PBRM1,EGFR,PIK3R1,CDKN2A,GATA3,RB1,NOTCH1,FBXW7,CTNNB1,DNMT3A,TSHZ3,ARHGAP35,CTCF,NFE2L2,NPM1,RUNX1,TBX3,CEBPA,AR,TSHZ2,SOX9,ATM,WT1,HGF,TLR4,ARID5B,TET2,ATRX,ELF3,BRCA1,FOXA1,KIT,HIST1H1C,SETD2,EP300,FGFR2,CCND1,SMAD4,FOXA2,USP9X,NFE2L3,ASXL1,SOX17,CDKN1A,TAF1,CBFB,SIN3A,VEZF1,CDK12,PHF6,NSD1,TBL1XR1,EGR3,ACVR2A,NCOR1,SMAD2,RAD21,ERCC2,EZH2
GO:0031325	positive regulation of cellular metabolic process	3.162638807382091e-26	3.162638807382091e-26	+1	TP53,PTEN,VHL,KRAS,ARID1A,EGFR,PIK3R1,CDKN2A,GATA3,RB1,NOTCH1,FBXW7,CTNNB1,MAP3K1,FLT3,KEAP1,CDH1,CTCF,NFE2L2,NPM1,RUNX1,MAP2K4,STK11,CEBPA,AKT1,BRAF,AR,PIK3CG,SOX9,ATM,WT1,HGF,ERBB4,MTOR,TLR4,TET2,ATRX,ELF3,BRCA1,LRRK2,FOXA1,CHEK2,KIT,HIST1H1C,PDGFRA,EP300,FGFR2,CCND1,SMAD4,FOXA2,USP9X,BRCA2,NFE2L3,FGFR3,ASXL1,TGFBR2,SOX17,CDKN1A,TAF1,ATR,SIN3A,VEZF1,CDK12,PTPN11,MAPK8IP1,NSD1,TBL1XR1,EGR3,ACVR2A,MECOM,RPL5,SMAD2,AXIN2,ERCC2,EZH2
GO:0048518	positive regulation of biological process	4.3538305878677013e-26	4.3538305878677013e-26	+1	TP53,PIK3CA,PTEN,APC,VHL,KRAS,ARID1A,NAV3,EGFR,NF1,PIK3R1,CDKN2A,GATA3,RB1,NOTCH1,FBXW7,CTNNB1,MAP3K1,FLT3,TSHZ3,KEAP1,CDH1,ARHGAP35,CTCF,NFE2L2,BAP1,NPM1,RUNX1,NRAS,TBX3,MAP2K4,STK11,CEBPA,EPHA3,AKT1,BRAF,AR,AJUBA,PIK3CG,SOX9,ATM,CDKN1B,WT1,HGF,ERBB4,MTOR,TLR4,ARID5B,TET2,ATRX,ELF3,BRCA1,LRRK2,FOXA1,CHEK2,KIT,HIST1H1C,SETD2,PDGFRA,EP300,FGFR2,CCND1,SMAD4,FOXA2,USP9X,BRCA2,NFE2L3,FGFR3,ASXL1,TGFBR2,SOX17,CDKN1A,SF3B1,TAF1,CBFB,ATR,SIN3A,VEZF1,CDK12,PTPN11,ACVR1B,MAPK8IP1,H3F3C,NSD1,TBL1XR1,EGR3,ACVR2A,MECOM,LIFR,SMC3,NCOR1,RPL5,SMAD2,AXIN2,MIR142,RAD21,ERCC2,EZH2
GO:0043170	macromolecule metabolic process	3.654557289489733e-25	3.654557289489733e-25	+1	TP53,PIK3CA,PTEN,APC,VHL,KRAS,ARID1A,PBRM1,EGFR,NF1,PIK3R1,CDKN2A,GATA3,RB1,NOTCH1,FBXW7,CTNNB1,DNMT3A,MAP3K1,FLT3,TSHZ3,KEAP1,CDH1,ARHGAP35,CTCF,NFE2L2,BAP1,NPM1,RUNX1,NRAS,TBX3,MAP2K4,STK11,CRIPAK,CEBPA,KDM6A,EPHA3,AKT1,STAG2,BRAF,AR,AJUBA,TSHZ2,PIK3CG,SOX9,ATM,CDKN1B,WT1,HGF,KDM5C,PRX,ERBB4,MTOR,TLR4,U2AF1,ARID5B,TET2,ATRX,ELF3,BRCA1,LRRK2,POLQ,FOXA1,CHEK2,KIT,HIST1H1C,SETD2,PDGFRA,EP300,FGFR2,CCND1,SMAD4,FOXA2,USP9X,BRCA2,NFE2L3,FGFR3,ASXL1,TGFBR2,SOX17,CDKN1A,B4GALT3,SF3B1,TAF1,PPP2R1A,CBFB,ATR,SIN3A,VEZF1,HIST1H2BD,EIF4A2,CDK12,PHF6,SMC1A,PTPN11,ACVR1B,MAPK8IP1,NSD1,TBL1XR1,EGR3,ACVR2A,MECOM,SMC3,NCOR1,RPL5,SMAD2,SPOP,AXIN2,RAD21,ERCC2,CDKN2C,EZH2,PCBP1
GO:0034654	nucleobase-containing compound biosynthetic process	3.8562400529014085e-25	3.8562400529014085e-25	+1	TP53,PTEN,VHL,ARID1A,PBRM1,EGFR,PIK3R1,CDKN2A,GATA3,RB1,NOTCH1,FBXW7,CTNNB1,DNMT3A,TSHZ3,KEAP1,CDH1,ARHGAP35,CTCF,NFE2L2,NPM1,RUNX1,TBX3,CEBPA,AKT1,AR,TSHZ2,SOX9,ATM,CDKN1B,WT1,HGF,KDM5C,ERBB4,MTOR,TLR4,ARID5B,TET2,ATRX,ELF3,BRCA1,FOXA1,CHEK2,KIT,HIST1H1C,SETD2,EP300,FGFR2,CCND1,SMAD4,FOXA2,USP9X,BRCA2,NFE2L3,ASXL1,SOX17,CDKN1A,TAF1,PPP2R1A,CBFB,ATR,SIN3A,VEZF1,EIF4A2,CDK12,PHF6,ACVR1B,NSD1,TBL1XR1,EGR3,ACVR2A,MECOM,NCOR1,SMAD2,RAD21,ERCC2,EZH2
GO:0006357	regulation of transcription by RNA polymerase II	4.271715118877375e-25	4.271715118877375e-25	+1	TP53,VHL,ARID1A,EGFR,PIK3R1,CDKN2A,GATA3,RB1,NOTCH1,FBXW7,CTNNB1,DNMT3A,TSHZ3,ARHGAP35,CTCF,NFE2L2,NPM1,RUNX1,TBX3,CEBPA,AR,TSHZ2,SOX9,ATM,WT1,HGF,TLR4,ARID5B,TET2,ATRX,ELF3,BRCA1,FOXA1,KIT,HIST1H1C,EP300,FGFR2,CCND1,SMAD4,FOXA2,USP9X,ASXL1,SOX17,CDKN1A,TAF1,CBFB,SIN3A,VEZF1,CDK12,PHF6,NSD1,TBL1XR1,EGR3,ACVR2A,NCOR1,SMAD2,RAD21,ERCC2,EZH2
GO:0016070	RNA metabolic process	6.971484942892851e-25	6.971484942892851e-25	+1	TP53,PTEN,VHL,ARID1A,PBRM1,EGFR,PIK3R1,CDKN2A,GATA3,RB1,NOTCH1,FBXW7,CTNNB1,DNMT3A,TSHZ3,KEAP1,CDH1,ARHGAP35,CTCF,NFE2L2,NPM1,RUNX1,TBX3,CEBPA,AKT1,AR,TSHZ2,SOX9,ATM,CDKN1B,WT1,HGF,KDM5C,PRX,ERBB4,MTOR,TLR4,U2AF1,ARID5B,TET2,ATRX,ELF3,BRCA1,FOXA1,CHEK2,KIT,HIST1H1C,SETD2,EP300,FGFR2,CCND1,SMAD4,FOXA2,USP9X,BRCA2,NFE2L3,ASXL1,SOX17,CDKN1A,SF3B1,TAF1,PPP2R1A,CBFB,SIN3A,VEZF1,EIF4A2,CDK12,PHF6,ACVR1B,NSD1,TBL1XR1,EGR3,ACVR2A,MECOM,NCOR1,RPL5,SMAD2,AXIN2,RAD21,ERCC2,EZH2,PCBP1
GO:0018130	heterocycle biosynthetic process	1.0225501817281751e-24	1.0225501817281751e-24	+1	TP53,PTEN,VHL,ARID1A,PBRM1,EGFR,PIK3R1,CDKN2A,GATA3,RB1,NOTCH1,FBXW7,CTNNB1,DNMT3A,TSHZ3,KEAP1,CDH1,ARHGAP35,CTCF,NFE2L2,NPM1,RUNX1,TBX3,CEBPA,AKT1,AR,TSHZ2,SOX9,ATM,CDKN1B,WT1,HGF,KDM5C,ERBB4,MTOR,TLR4,ARID5B,TET2,ATRX,ELF3,BRCA1,FOXA1,CHEK2,KIT,HIST1H1C,SETD2,EP300,FGFR2,CCND1,SMAD4,FOXA2,USP9X,BRCA2,NFE2L3,ASXL1,SOX17,CDKN1A,TAF1,PPP2R1A,CBFB,ATR,SIN3A,VEZF1,EIF4A2,CDK12,PHF6,ACVR1B,NSD1,TBL1XR1,EGR3,ACVR2A,MECOM,NCOR1,SMAD2,RAD21,ERCC2,EZH2
GO:0019438	aromatic compound biosynthetic process	1.0225501817281751e-24	1.0225501817281751e-24	+1	TP53,PTEN,VHL,ARID1A,PBRM1,EGFR,PIK3R1,CDKN2A,GATA3,RB1,NOTCH1,FBXW7,CTNNB1,DNMT3A,TSHZ3,KEAP1,CDH1,ARHGAP35,CTCF,NFE2L2,NPM1,RUNX1,TBX3,CEBPA,AKT1,AR,TSHZ2,SOX9,ATM,CDKN1B,WT1,HGF,KDM5C,ERBB4,MTOR,TLR4,ARID5B,TET2,ATRX,ELF3,BRCA1,FOXA1,CHEK2,KIT,HIST1H1C,SETD2,EP300,FGFR2,CCND1,SMAD4,FOXA2,USP9X,BRCA2,NFE2L3,ASXL1,SOX17,CDKN1A,TAF1,PPP2R1A,CBFB,ATR,SIN3A,VEZF1,EIF4A2,CDK12,PHF6,ACVR1B,NSD1,TBL1XR1,EGR3,ACVR2A,MECOM,NCOR1,SMAD2,RAD21,ERCC2,EZH2
GO:0090304	nucleic acid metabolic process	1.0225501817281751e-24	1.0225501817281751e-24	+1	TP53,PTEN,VHL,ARID1A,PBRM1,EGFR,PIK3R1,CDKN2A,GATA3,RB1,NOTCH1,FBXW7,CTNNB1,DNMT3A,TSHZ3,KEAP1,CDH1,ARHGAP35,CTCF,NFE2L2,NPM1,RUNX1,TBX3,CRIPAK,CEBPA,AKT1,AR,TSHZ2,SOX9,ATM,CDKN1B,WT1,HGF,KDM5C,PRX,ERBB4,MTOR,TLR4,U2AF1,ARID5B,TET2,ATRX,ELF3,BRCA1,POLQ,FOXA1,CHEK2,KIT,HIST1H1C,SETD2,EP300,FGFR2,CCND1,SMAD4,FOXA2,USP9X,BRCA2,NFE2L3,ASXL1,SOX17,CDKN1A,SF3B1,TAF1,PPP2R1A,CBFB,ATR,SIN3A,VEZF1,EIF4A2,CDK12,PHF6,SMC1A,ACVR1B,NSD1,TBL1XR1,EGR3,ACVR2A,MECOM,NCOR1,RPL5,SMAD2,AXIN2,RAD21,ERCC2,EZH2,PCBP1
GO:0044260	cellular macromolecule metabolic process	1.836846324951449e-24	1.836846324951449e-24	+1	TP53,PIK3CA,PTEN,APC,VHL,KRAS,ARID1A,PBRM1,EGFR,NF1,PIK3R1,CDKN2A,GATA3,RB1,NOTCH1,FBXW7,CTNNB1,DNMT3A,MAP3K1,FLT3,TSHZ3,KEAP1,CDH1,ARHGAP35,CTCF,NFE2L2,BAP1,NPM1,RUNX1,NRAS,TBX3,MAP2K4,STK11,CRIPAK,CEBPA,KDM6A,EPHA3,AKT1,STAG2,BRAF,AR,TSHZ2,PIK3CG,SOX9,ATM,CDKN1B,WT1,HGF,KDM5C,ERBB4,MTOR,TLR4,ARID5B,TET2,ATRX,ELF3,BRCA1,LRRK2,POLQ,FOXA1,CHEK2,KIT,HIST1H1C,SETD2,PDGFRA,EP300,FGFR2,CCND1,SMAD4,FOXA2,USP9X,BRCA2,NFE2L3,FGFR3,ASXL1,TGFBR2,SOX17,CDKN1A,TAF1,PPP2R1A,CBFB,ATR,SIN3A,VEZF1,HIST1H2BD,EIF4A2,CDK12,PHF6,SMC1A,PTPN11,ACVR1B,MAPK8IP1,NSD1,TBL1XR1,EGR3,ACVR2A,MECOM,SMC3,NCOR1,RPL5,SMAD2,SPOP,AXIN2,RAD21,ERCC2,CDKN2C,EZH2
GO:0048519	negative regulation of biological process	1.9278803953640608e-24	1.9278803953640608e-24	+1	TP53,PIK3CA,PTEN,APC,VHL,PBRM1,NAV3,EGFR,NF1,PIK3R1,CDKN2A,GATA3,RB1,NOTCH1,FBXW7,CTNNB1,DNMT3A,TSHZ3,KEAP1,CDH1,ARHGAP35,CTCF,NFE2L2,BAP1,NPM1,RUNX1,TBX3,STK11,CRIPAK,CEBPA,EPHA3,AKT1,STAG2,BRAF,AR,AJUBA,EPPK1,PIK3CG,SOX9,ATM,CDKN1B,WT1,HGF,KDM5C,ERBB4,MTOR,TLR4,ARID5B,ATRX,ELF3,BRCA1,LRRK2,POLQ,FOXA1,CHEK2,HIST1H1C,PDGFRA,EP300,FGFR2,CCND1,SMAD4,FOXA2,USP9X,BRCA2,FGFR3,ASXL1,TGFBR2,SOX17,CDKN1A,TAF1,PPP2R1A,CBFB,ATR,SIN3A,EIF4A2,PHF6,SMC1A,ACVR1B,MAPK8IP1,NSD1,TBL1XR1,EGR3,MECOM,SMC3,NCOR1,RPL5,SMAD2,AXIN2,CDKN2C,EZH2
GO:0009892	negative regulation of metabolic process	2.0471219353489164e-24	2.0471219353489164e-24	+1	TP53,PIK3CA,PTEN,APC,VHL,EGFR,NF1,CDKN2A,GATA3,RB1,NOTCH1,FBXW7,CTNNB1,DNMT3A,TSHZ3,ARHGAP35,CTCF,NPM1,RUNX1,TBX3,STK11,CRIPAK,CEBPA,AKT1,STAG2,AR,AJUBA,SOX9,ATM,CDKN1B,WT1,HGF,KDM5C,MTOR,TLR4,ARID5B,ATRX,ELF3,BRCA1,LRRK2,POLQ,CHEK2,HIST1H1C,EP300,FGFR2,CCND1,SMAD4,FOXA2,USP9X,SOX17,CDKN1A,TAF1,PPP2R1A,CBFB,ATR,SIN3A,EIF4A2,PHF6,SMC1A,MAPK8IP1,NSD1,TBL1XR1,MECOM,SMC3,NCOR1,RPL5,SMAD2,AXIN2,CDKN2C,EZH2
GO:0010628	positive regulation of gene expression	6.559142711379659e-24	6.559142711379659e-24	+1	TP53,VHL,KRAS,ARID1A,EGFR,PIK3R1,CDKN2A,GATA3,RB1,NOTCH1,FBXW7,CTNNB1,CDH1,CTCF,NFE2L2,NPM1,RUNX1,CEBPA,AKT1,BRAF,AR,SOX9,ATM,WT1,HGF,ERBB4,MTOR,TLR4,TET2,ATRX,ELF3,BRCA1,FOXA1,CHEK2,HIST1H1C,EP300,FGFR2,SMAD4,FOXA2,BRCA2,NFE2L3,ASXL1,SOX17,SF3B1,TAF1,SIN3A,VEZF1,CDK12,NSD1,TBL1XR1,EGR3,ACVR2A,MECOM,NCOR1,RPL5,SMAD2,AXIN2,ERCC2
GO:0045893	positive regulation of transcription, DNA-templated	7.548542510987933e-24	7.548542510987933e-24	+1	TP53,VHL,ARID1A,EGFR,PIK3R1,CDKN2A,GATA3,RB1,NOTCH1,FBXW7,CTNNB1,CDH1,CTCF,NFE2L2,NPM1,RUNX1,CEBPA,AKT1,AR,SOX9,ATM,WT1,HGF,ERBB4,MTOR,TLR4,TET2,ATRX,ELF3,BRCA1,FOXA1,CHEK2,HIST1H1C,EP300,FGFR2,SMAD4,FOXA2,BRCA2,NFE2L3,ASXL1,SOX17,TAF1,SIN3A,VEZF1,CDK12,NSD1,TBL1XR1,EGR3,ACVR2A,MECOM,SMAD2,ERCC2
GO:1903508	positive regulation of nucleic acid-templated transcription	7.938863593887303e-24	7.938863593887303e-24	+1	TP53,VHL,ARID1A,EGFR,PIK3R1,CDKN2A,GATA3,RB1,NOTCH1,FBXW7,CTNNB1,CDH1,CTCF,NFE2L2,NPM1,RUNX1,CEBPA,AKT1,AR,SOX9,ATM,WT1,HGF,ERBB4,MTOR,TLR4,TET2,ATRX,ELF3,BRCA1,FOXA1,CHEK2,HIST1H1C,EP300,FGFR2,SMAD4,FOXA2,BRCA2,NFE2L3,ASXL1,SOX17,TAF1,SIN3A,VEZF1,CDK12,NSD1,TBL1XR1,EGR3,ACVR2A,MECOM,SMAD2,ERCC2
GO:1902680	positive regulation of RNA biosynthetic process	8.043719731340159e-24	8.043719731340159e-24	+1	TP53,VHL,ARID1A,EGFR,PIK3R1,CDKN2A,GATA3,RB1,NOTCH1,FBXW7,CTNNB1,CDH1,CTCF,NFE2L2,NPM1,RUNX1,CEBPA,AKT1,AR,SOX9,ATM,WT1,HGF,ERBB4,MTOR,TLR4,TET2,ATRX,ELF3,BRCA1,FOXA1,CHEK2,HIST1H1C,EP300,FGFR2,SMAD4,FOXA2,BRCA2,NFE2L3,ASXL1,SOX17,TAF1,SIN3A,VEZF1,CDK12,NSD1,TBL1XR1,EGR3,ACVR2A,MECOM,SMAD2,ERCC2
GO:1901362	organic cyclic compound biosynthetic process	1.1760523770354288e-23	1.1760523770354288e-23	+1	TP53,PTEN,VHL,ARID1A,PBRM1,EGFR,PIK3R1,CDKN2A,GATA3,RB1,NOTCH1,FBXW7,CTNNB1,DNMT3A,TSHZ3,KEAP1,CDH1,ARHGAP35,CTCF,NFE2L2,NPM1,RUNX1,TBX3,CEBPA,AKT1,AR,TSHZ2,SOX9,ATM,CDKN1B,WT1,HGF,KDM5C,ERBB4,MTOR,TLR4,ARID5B,TET2,ATRX,ELF3,BRCA1,FOXA1,CHEK2,KIT,HIST1H1C,SETD2,EP300,FGFR2,CCND1,SMAD4,FOXA2,USP9X,BRCA2,NFE2L3,ASXL1,SOX17,CDKN1A,TAF1,PPP2R1A,CBFB,ATR,SIN3A,VEZF1,EIF4A2,CDK12,PHF6,ACVR1B,NSD1,TBL1XR1,EGR3,ACVR2A,MECOM,NCOR1,SMAD2,RAD21,ERCC2,EZH2
GO:0034645	cellular macromolecule biosynthetic process	4.6601397145995355e-23	4.6601397145995355e-23	+1	TP53,PTEN,VHL,ARID1A,PBRM1,EGFR,PIK3R1,CDKN2A,GATA3,RB1,NOTCH1,FBXW7,CTNNB1,DNMT3A,TSHZ3,KEAP1,CDH1,ARHGAP35,CTCF,NFE2L2,NPM1,RUNX1,TBX3,CEBPA,AKT1,STAG2,AR,TSHZ2,SOX9,ATM,CDKN1B,WT1,HGF,KDM5C,ERBB4,MTOR,TLR4,ARID5B,TET2,ATRX,ELF3,BRCA1,POLQ,FOXA1,CHEK2,KIT,HIST1H1C,SETD2,EP300,FGFR2,CCND1,SMAD4,FOXA2,USP9X,BRCA2,NFE2L3,ASXL1,SOX17,CDKN1A,TAF1,PPP2R1A,CBFB,ATR,SIN3A,VEZF1,EIF4A2,CDK12,PHF6,SMC1A,ACVR1B,NSD1,TBL1XR1,EGR3,ACVR2A,MECOM,SMC3,NCOR1,RPL5,SMAD2,RAD21,ERCC2,EZH2
GO:0009059	macromolecule biosynthetic process	4.6601397145995355e-23	4.6601397145995355e-23	+1	TP53,PTEN,VHL,ARID1A,PBRM1,EGFR,PIK3R1,CDKN2A,GATA3,RB1,NOTCH1,FBXW7,CTNNB1,DNMT3A,TSHZ3,KEAP1,CDH1,ARHGAP35,CTCF,NFE2L2,NPM1,RUNX1,TBX3,CEBPA,AKT1,STAG2,AR,TSHZ2,SOX9,ATM,CDKN1B,WT1,HGF,KDM5C,ERBB4,MTOR,TLR4,ARID5B,TET2,ATRX,ELF3,BRCA1,POLQ,FOXA1,CHEK2,KIT,HIST1H1C,SETD2,EP300,FGFR2,CCND1,SMAD4,FOXA2,USP9X,BRCA2,NFE2L3,ASXL1,SOX17,CDKN1A,B4GALT3,TAF1,PPP2R1A,CBFB,ATR,SIN3A,VEZF1,EIF4A2,CDK12,PHF6,SMC1A,ACVR1B,NSD1,TBL1XR1,EGR3,ACVR2A,MECOM,SMC3,NCOR1,RPL5,SMAD2,RAD21,ERCC2,EZH2
GO:0043412	macromolecule modification	9.639205322762757e-23	9.639205322762757e-23	+1	TP53,PIK3CA,PTEN,APC,VHL,KRAS,EGFR,NF1,CDKN2A,GATA3,RB1,NOTCH1,FBXW7,CTNNB1,DNMT3A,MAP3K1,FLT3,KEAP1,NFE2L2,BAP1,NPM1,NRAS,MAP2K4,STK11,CRIPAK,CEBPA,KDM6A,EPHA3,AKT1,BRAF,AR,PIK3CG,SOX9,ATM,CDKN1B,WT1,HGF,KDM5C,ERBB4,MTOR,TLR4,TET2,ATRX,BRCA1,LRRK2,CHEK2,KIT,HIST1H1C,SETD2,PDGFRA,EP300,FGFR2,CCND1,SMAD4,USP9X,BRCA2,FGFR3,ASXL1,TGFBR2,CDKN1A,TAF1,PPP2R1A,CBFB,ATR,SIN3A,HIST1H2BD,CDK12,PTPN11,ACVR1B,MAPK8IP1,NSD1,TBL1XR1,ACVR2A,MECOM,NCOR1,RPL5,SMAD2,AXIN2,CDKN2C,EZH2
GO:0051254	positive regulation of RNA metabolic process	1.0346306707139994e-22	1.0346306707139994e-22	+1	TP53,VHL,ARID1A,EGFR,PIK3R1,CDKN2A,GATA3,RB1,NOTCH1,FBXW7,CTNNB1,CDH1,CTCF,NFE2L2,NPM1,RUNX1,CEBPA,AKT1,AR,SOX9,ATM,WT1,HGF,ERBB4,MTOR,TLR4,TET2,ATRX,ELF3,BRCA1,FOXA1,CHEK2,HIST1H1C,EP300,FGFR2,SMAD4,FOXA2,BRCA2,NFE2L3,ASXL1,SOX17,TAF1,SIN3A,VEZF1,CDK12,NSD1,TBL1XR1,EGR3,ACVR2A,MECOM,SMAD2,ERCC2
GO:0036211	protein modification process	1.1958879834752708e-22	1.1958879834752708e-22	+1	TP53,PIK3CA,PTEN,APC,VHL,KRAS,EGFR,NF1,CDKN2A,GATA3,RB1,NOTCH1,FBXW7,CTNNB1,MAP3K1,FLT3,KEAP1,NFE2L2,BAP1,NPM1,NRAS,MAP2K4,STK11,CRIPAK,CEBPA,KDM6A,EPHA3,AKT1,BRAF,AR,PIK3CG,SOX9,ATM,CDKN1B,HGF,KDM5C,ERBB4,MTOR,TLR4,TET2,ATRX,BRCA1,LRRK2,CHEK2,KIT,HIST1H1C,SETD2,PDGFRA,EP300,FGFR2,CCND1,SMAD4,USP9X,BRCA2,FGFR3,ASXL1,TGFBR2,CDKN1A,TAF1,PPP2R1A,CBFB,ATR,SIN3A,HIST1H2BD,CDK12,PTPN11,ACVR1B,MAPK8IP1,NSD1,TBL1XR1,ACVR2A,MECOM,NCOR1,RPL5,SMAD2,AXIN2,CDKN2C,EZH2
GO:0006464	cellular protein modification process	1.1958879834752708e-22	1.1958879834752708e-22	+1	TP53,PIK3CA,PTEN,APC,VHL,KRAS,EGFR,NF1,CDKN2A,GATA3,RB1,NOTCH1,FBXW7,CTNNB1,MAP3K1,FLT3,KEAP1,NFE2L2,BAP1,NPM1,NRAS,MAP2K4,STK11,CRIPAK,CEBPA,KDM6A,EPHA3,AKT1,BRAF,AR,PIK3CG,SOX9,ATM,CDKN1B,HGF,KDM5C,ERBB4,MTOR,TLR4,TET2,ATRX,BRCA1,LRRK2,CHEK2,KIT,HIST1H1C,SETD2,PDGFRA,EP300,FGFR2,CCND1,SMAD4,USP9X,BRCA2,FGFR3,ASXL1,TGFBR2,CDKN1A,TAF1,PPP2R1A,CBFB,ATR,SIN3A,HIST1H2BD,CDK12,PTPN11,ACVR1B,MAPK8IP1,NSD1,TBL1XR1,ACVR2A,MECOM,NCOR1,RPL5,SMAD2,AXIN2,CDKN2C,EZH2
GO:0010557	positive regulation of macromolecule biosynthetic process	1.4100589547527098e-22	1.4100589547527098e-22	+1	TP53,VHL,ARID1A,EGFR,PIK3R1,CDKN2A,GATA3,RB1,NOTCH1,FBXW7,CTNNB1,CDH1,CTCF,NFE2L2,NPM1,RUNX1,CEBPA,AKT1,AR,SOX9,ATM,WT1,HGF,ERBB4,MTOR,TLR4,TET2,ATRX,ELF3,BRCA1,FOXA1,CHEK2,HIST1H1C,EP300,FGFR2,SMAD4,FOXA2,BRCA2,NFE2L3,ASXL1,SOX17,TAF1,ATR,SIN3A,VEZF1,CDK12,NSD1,TBL1XR1,EGR3,ACVR2A,MECOM,RPL5,SMAD2,ERCC2
GO:0045935	positive regulation of nucleobase-containing compound metabolic process	1.476414271700595e-22	1.476414271700595e-22	+1	TP53,VHL,ARID1A,EGFR,PIK3R1,CDKN2A,GATA3,RB1,NOTCH1,FBXW7,CTNNB1,CDH1,CTCF,NFE2L2,NPM1,RUNX1,CEBPA,AKT1,AR,SOX9,ATM,WT1,HGF,ERBB4,MTOR,TLR4,TET2,ATRX,ELF3,BRCA1,FOXA1,CHEK2,HIST1H1C,EP300,FGFR2,SMAD4,FOXA2,USP9X,BRCA2,NFE2L3,ASXL1,SOX17,TAF1,ATR,SIN3A,VEZF1,CDK12,NSD1,TBL1XR1,EGR3,ACVR2A,MECOM,SMAD2,ERCC2
GO:0006139	nucleobase-containing compound metabolic process	1.8133276454892326e-22	1.8133276454892326e-22	+1	TP53,PTEN,VHL,ARID1A,PBRM1,EGFR,PIK3R1,CDKN2A,GATA3,RB1,NOTCH1,FBXW7,CTNNB1,DNMT3A,TSHZ3,KEAP1,CDH1,ARHGAP35,CTCF,NFE2L2,NPM1,RUNX1,TBX3,CRIPAK,CEBPA,AKT1,AR,TSHZ2,SOX9,ATM,CDKN1B,WT1,HGF,KDM5C,PRX,ERBB4,MTOR,TLR4,U2AF1,ARID5B,TET2,ATRX,ELF3,BRCA1,LRRK2,POLQ,FOXA1,CHEK2,KIT,HIST1H1C,SETD2,EP300,FGFR2,CCND1,SMAD4,FOXA2,USP9X,BRCA2,NFE2L3,ASXL1,SOX17,CDKN1A,SF3B1,TAF1,PPP2R1A,CBFB,ATR,SIN3A,VEZF1,EIF4A2,CDK12,PHF6,SMC1A,ACVR1B,NSD1,TBL1XR1,EGR3,ACVR2A,MECOM,NCOR1,RPL5,SMAD2,AXIN2,RAD21,ERCC2,EZH2,PCBP1
GO:0010605	negative regulation of macromolecule metabolic process	2.4857283475023103e-22	2.4857283475023103e-22	+1	TP53,PTEN,APC,VHL,EGFR,NF1,CDKN2A,GATA3,RB1,NOTCH1,FBXW7,CTNNB1,DNMT3A,TSHZ3,ARHGAP35,CTCF,NPM1,RUNX1,TBX3,CRIPAK,CEBPA,AKT1,STAG2,AR,AJUBA,SOX9,ATM,CDKN1B,WT1,HGF,KDM5C,TLR4,ARID5B,ATRX,ELF3,BRCA1,LRRK2,POLQ,CHEK2,HIST1H1C,EP300,FGFR2,CCND1,SMAD4,USP9X,SOX17,CDKN1A,TAF1,PPP2R1A,CBFB,ATR,SIN3A,EIF4A2,PHF6,SMC1A,MAPK8IP1,NSD1,TBL1XR1,MECOM,SMC3,NCOR1,RPL5,SMAD2,AXIN2,EZH2
GO:0006468	protein phosphorylation	6.30966325196208e-22	6.30966325196208e-22	+1	TP53,PIK3CA,PTEN,APC,KRAS,EGFR,NF1,CDKN2A,RB1,NOTCH1,FBXW7,MAP3K1,FLT3,NPM1,NRAS,MAP2K4,STK11,CRIPAK,CEBPA,EPHA3,AKT1,BRAF,PIK3CG,SOX9,ATM,CDKN1B,HGF,ERBB4,MTOR,TLR4,LRRK2,CHEK2,KIT,PDGFRA,FGFR2,CCND1,SMAD4,FGFR3,TGFBR2,CDKN1A,TAF1,PPP2R1A,ATR,CDK12,PTPN11,ACVR1B,MAPK8IP1,NSD1,ACVR2A,MECOM,NCOR1,SMAD2,AXIN2,CDKN2C,EZH2
GO:0010467	gene expression	7.076820638321214e-22	7.076820638321214e-22	+1	TP53,PTEN,VHL,KRAS,ARID1A,PBRM1,EGFR,PIK3R1,CDKN2A,GATA3,RB1,NOTCH1,FBXW7,CTNNB1,DNMT3A,TSHZ3,KEAP1,CDH1,ARHGAP35,CTCF,NFE2L2,NPM1,RUNX1,TBX3,CEBPA,AKT1,BRAF,AR,AJUBA,TSHZ2,SOX9,ATM,CDKN1B,WT1,HGF,KDM5C,PRX,ERBB4,MTOR,TLR4,U2AF1,ARID5B,TET2,ATRX,ELF3,BRCA1,LRRK2,FOXA1,CHEK2,KIT,HIST1H1C,SETD2,EP300,FGFR2,CCND1,SMAD4,FOXA2,USP9X,BRCA2,NFE2L3,ASXL1,SOX17,CDKN1A,SF3B1,TAF1,PPP2R1A,CBFB,SIN3A,VEZF1,EIF4A2,CDK12,PHF6,ACVR1B,NSD1,TBL1XR1,EGR3,ACVR2A,MECOM,NCOR1,RPL5,SMAD2,AXIN2,RAD21,ERCC2,EZH2,PCBP1
GO:0031328	positive regulation of cellular biosynthetic process	7.954651525953081e-22	7.954651525953081e-22	+1	TP53,VHL,ARID1A,EGFR,PIK3R1,CDKN2A,GATA3,RB1,NOTCH1,FBXW7,CTNNB1,CDH1,CTCF,NFE2L2,NPM1,RUNX1,CEBPA,AKT1,AR,SOX9,ATM,WT1,HGF,ERBB4,MTOR,TLR4,TET2,ATRX,ELF3,BRCA1,FOXA1,CHEK2,HIST1H1C,EP300,FGFR2,SMAD4,FOXA2,BRCA2,NFE2L3,ASXL1,SOX17,TAF1,ATR,SIN3A,VEZF1,CDK12,NSD1,TBL1XR1,EGR3,ACVR2A,MECOM,RPL5,SMAD2,ERCC2
GO:0031399	regulation of protein modification process	1.2450268715347465e-21	1.2450268715347465e-21	+1	TP53,PTEN,APC,KRAS,EGFR,NF1,CDKN2A,RB1,NOTCH1,FBXW7,CTNNB1,MAP3K1,FLT3,NPM1,MAP2K4,STK11,CRIPAK,CEBPA,AKT1,BRAF,PIK3CG,SOX9,CDKN1B,HGF,ERBB4,MTOR,TLR4,ATRX,BRCA1,LRRK2,KIT,PDGFRA,EP300,FGFR2,CCND1,SMAD4,FGFR3,TGFBR2,CDKN1A,TAF1,PPP2R1A,SIN3A,CDK12,PTPN11,MAPK8IP1,NSD1,ACVR2A,MECOM,NCOR1,RPL5,AXIN2,CDKN2C,EZH2
GO:0009891	positive regulation of biosynthetic process	1.7883871600742125e-21	1.7883871600742125e-21	+1	TP53,VHL,ARID1A,EGFR,PIK3R1,CDKN2A,GATA3,RB1,NOTCH1,FBXW7,CTNNB1,CDH1,CTCF,NFE2L2,NPM1,RUNX1,CEBPA,AKT1,AR,SOX9,ATM,WT1,HGF,ERBB4,MTOR,TLR4,TET2,ATRX,ELF3,BRCA1,FOXA1,CHEK2,HIST1H1C,EP300,FGFR2,SMAD4,FOXA2,BRCA2,NFE2L3,ASXL1,SOX17,TAF1,ATR,SIN3A,VEZF1,CDK12,NSD1,TBL1XR1,EGR3,ACVR2A,MECOM,RPL5,SMAD2,ERCC2
GO:0046483	heterocycle metabolic process	2.1263786327066518e-21	2.1263786327066518e-21	+1	TP53,PTEN,VHL,ARID1A,PBRM1,EGFR,PIK3R1,CDKN2A,GATA3,RB1,NOTCH1,FBXW7,CTNNB1,DNMT3A,TSHZ3,KEAP1,CDH1,ARHGAP35,CTCF,NFE2L2,NPM1,RUNX1,TBX3,CRIPAK,CEBPA,AKT1,AR,TSHZ2,SOX9,ATM,CDKN1B,WT1,HGF,KDM5C,PRX,ERBB4,MTOR,TLR4,U2AF1,ARID5B,TET2,ATRX,ELF3,BRCA1,LRRK2,POLQ,FOXA1,CHEK2,KIT,HIST1H1C,SETD2,EP300,FGFR2,CCND1,SMAD4,FOXA2,USP9X,BRCA2,NFE2L3,ASXL1,SOX17,CDKN1A,SF3B1,TAF1,PPP2R1A,CBFB,ATR,SIN3A,VEZF1,EIF4A2,CDK12,PHF6,SMC1A,ACVR1B,NSD1,TBL1XR1,EGR3,ACVR2A,MECOM,NCOR1,RPL5,SMAD2,AXIN2,RAD21,ERCC2,EZH2,PCBP1
GO:0006725	cellular aromatic compound metabolic process	2.778965317347105e-21	2.778965317347105e-21	+1	TP53,PTEN,VHL,ARID1A,PBRM1,EGFR,PIK3R1,CDKN2A,GATA3,RB1,NOTCH1,FBXW7,CTNNB1,DNMT3A,TSHZ3,KEAP1,CDH1,ARHGAP35,CTCF,NFE2L2,NPM1,RUNX1,TBX3,CRIPAK,CEBPA,AKT1,AR,TSHZ2,SOX9,ATM,CDKN1B,WT1,HGF,KDM5C,PRX,ERBB4,MTOR,TLR4,U2AF1,ARID5B,TET2,ATRX,ELF3,BRCA1,LRRK2,POLQ,FOXA1,CHEK2,KIT,HIST1H1C,SETD2,EP300,FGFR2,CCND1,SMAD4,FOXA2,USP9X,BRCA2,NFE2L3,ASXL1,SOX17,CDKN1A,SF3B1,TAF1,PPP2R1A,CBFB,ATR,SIN3A,VEZF1,EIF4A2,CDK12,PHF6,SMC1A,ACVR1B,NSD1,TBL1XR1,EGR3,ACVR2A,MECOM,NCOR1,RPL5,SMAD2,AXIN2,RAD21,ERCC2,EZH2,PCBP1
GO:0044271	cellular nitrogen compound biosynthetic process	2.8056082029082355e-21	2.8056082029082355e-21	+1	TP53,PTEN,VHL,ARID1A,PBRM1,EGFR,PIK3R1,CDKN2A,GATA3,RB1,NOTCH1,FBXW7,CTNNB1,DNMT3A,TSHZ3,KEAP1,CDH1,ARHGAP35,CTCF,NFE2L2,NPM1,RUNX1,TBX3,CEBPA,AKT1,AR,TSHZ2,SOX9,ATM,CDKN1B,WT1,HGF,KDM5C,ERBB4,MTOR,TLR4,ARID5B,TET2,ATRX,ELF3,BRCA1,FOXA1,CHEK2,KIT,HIST1H1C,SETD2,EP300,FGFR2,CCND1,SMAD4,FOXA2,USP9X,BRCA2,NFE2L3,ASXL1,SOX17,CDKN1A,B4GALT3,TAF1,PPP2R1A,CBFB,ATR,SIN3A,VEZF1,EIF4A2,CDK12,PHF6,ACVR1B,NSD1,TBL1XR1,EGR3,ACVR2A,MECOM,NCOR1,RPL5,SMAD2,RAD21,ERCC2,EZH2
GO:0016310	phosphorylation	2.9705422913312176e-21	2.9705422913312176e-21	+1	TP53,PIK3CA,PTEN,APC,KRAS,EGFR,NF1,PIK3R1,CDKN2A,RB1,NOTCH1,FBXW7,MAP3K1,FLT3,NPM1,NRAS,MAP2K4,STK11,CRIPAK,CEBPA,EPHA3,AKT1,BRAF,AR,PIK3CG,SOX9,ATM,CDKN1B,HGF,ERBB4,MTOR,TLR4,LRRK2,CHEK2,KIT,PDGFRA,FGFR2,CCND1,SMAD4,FOXA2,FGFR3,TGFBR2,CDKN1A,TAF1,PPP2R1A,ATR,CDK12,PTPN11,ACVR1B,MAPK8IP1,NSD1,ACVR2A,MECOM,NCOR1,SMAD2,AXIN2,CDKN2C,EZH2
GO:0051172	negative regulation of nitrogen compound metabolic process	3.00451671783578e-21	3.00451671783578e-21	+1	TP53,PTEN,APC,VHL,EGFR,NF1,CDKN2A,GATA3,RB1,NOTCH1,CTNNB1,DNMT3A,TSHZ3,ARHGAP35,CTCF,NPM1,RUNX1,TBX3,CRIPAK,CEBPA,AKT1,AR,SOX9,ATM,CDKN1B,WT1,HGF,KDM5C,TLR4,ARID5B,ATRX,ELF3,BRCA1,LRRK2,POLQ,HIST1H1C,EP300,FGFR2,CCND1,SMAD4,USP9X,SOX17,CDKN1A,TAF1,PPP2R1A,CBFB,SIN3A,EIF4A2,PHF6,MAPK8IP1,NSD1,TBL1XR1,MECOM,NCOR1,RPL5,SMAD2,AXIN2,EZH2
GO:0042325	regulation of phosphorylation	5.903531304319327e-21	5.903531304319327e-21	+1	TP53,PTEN,APC,KRAS,EGFR,NF1,PIK3R1,CDKN2A,RB1,NOTCH1,FBXW7,MAP3K1,FLT3,NPM1,MAP2K4,STK11,CRIPAK,CEBPA,AKT1,BRAF,AR,PIK3CG,SOX9,CDKN1B,HGF,ERBB4,MTOR,TLR4,LRRK2,KIT,PDGFRA,FGFR2,CCND1,SMAD4,FOXA2,FGFR3,TGFBR2,CDKN1A,PPP2R1A,CDK12,PTPN11,MAPK8IP1,NSD1,ACVR2A,MECOM,NCOR1,AXIN2,CDKN2C,EZH2
GO:0048583	regulation of response to stimulus	1.4212200391122998e-20	1.4212200391122998e-20	+1	TP53,PIK3CA,PTEN,APC,VHL,KRAS,EGFR,NF1,PIK3R1,CDKN2A,GATA3,RB1,NOTCH1,FBXW7,CTNNB1,MAP3K1,FLT3,ARHGAP35,NFE2L2,NPM1,RUNX1,NRAS,MAP2K4,STK11,CRIPAK,CEBPA,AKT1,BRAF,AR,AJUBA,EPPK1,PIK3CG,SOX9,ATM,CDKN1B,HGF,ERBB4,MTOR,TLR4,ELF3,BRCA1,LRRK2,POLQ,FOXA1,CHEK2,KIT,SETD2,PDGFRA,EP300,FGFR2,SMAD4,FOXA2,FGFR3,ASXL1,TGFBR2,SOX17,CDKN1A,TAF1,PPP2R1A,CBFB,ATR,SIN3A,CDK12,PTPN11,ACVR1B,MAPK8IP1,TBL1XR1,ACVR2A,MECOM,LIFR,NCOR1,RPL5,SMAD2,AXIN2,MIR142,EZH2
GO:1901360	organic cyclic compound metabolic process	5.2146782232471036e-20	5.2146782232471036e-20	+1	TP53,PTEN,VHL,ARID1A,PBRM1,EGFR,PIK3R1,CDKN2A,GATA3,RB1,NOTCH1,FBXW7,CTNNB1,DNMT3A,TSHZ3,KEAP1,CDH1,ARHGAP35,CTCF,NFE2L2,NPM1,RUNX1,TBX3,CRIPAK,CEBPA,AKT1,AR,TSHZ2,SOX9,ATM,CDKN1B,WT1,HGF,KDM5C,PRX,ERBB4,MTOR,TLR4,U2AF1,ARID5B,TET2,ATRX,ELF3,BRCA1,LRRK2,POLQ,FOXA1,CHEK2,KIT,HIST1H1C,SETD2,EP300,FGFR2,CCND1,SMAD4,FOXA2,USP9X,BRCA2,NFE2L3,ASXL1,SOX17,CDKN1A,SF3B1,TAF1,PPP2R1A,CBFB,ATR,SIN3A,VEZF1,EIF4A2,CDK12,PHF6,SMC1A,ACVR1B,NSD1,TBL1XR1,EGR3,ACVR2A,MECOM,NCOR1,RPL5,SMAD2,AXIN2,RAD21,ERCC2,EZH2,PCBP1
GO:0010558	negative regulation of macromolecule biosynthetic process	6.762995497810514e-20	6.762995497810514e-20	+1	TP53,VHL,CDKN2A,GATA3,RB1,NOTCH1,FBXW7,CTNNB1,DNMT3A,TSHZ3,ARHGAP35,CTCF,RUNX1,TBX3,CEBPA,STAG2,AR,SOX9,CDKN1B,WT1,KDM5C,ARID5B,ATRX,ELF3,BRCA1,CHEK2,HIST1H1C,EP300,FGFR2,CCND1,SMAD4,USP9X,SOX17,TAF1,CBFB,ATR,SIN3A,EIF4A2,PHF6,SMC1A,NSD1,TBL1XR1,MECOM,SMC3,NCOR1,SMAD2,EZH2
GO:0019220	regulation of phosphate metabolic process	6.762995497810514e-20	6.762995497810514e-20	+1	TP53,PTEN,APC,KRAS,EGFR,NF1,PIK3R1,CDKN2A,RB1,NOTCH1,FBXW7,MAP3K1,FLT3,NPM1,IDH1,MAP2K4,STK11,CRIPAK,CEBPA,AKT1,BRAF,AR,PIK3CG,SOX9,CDKN1B,HGF,ERBB4,MTOR,TLR4,LRRK2,KIT,PDGFRA,FGFR2,CCND1,SMAD4,FOXA2,FGFR3,TGFBR2,CDKN1A,PPP2R1A,CDK12,PTPN11,MAPK8IP1,NSD1,ACVR2A,MECOM,NCOR1,AXIN2,CDKN2C,EZH2
GO:0051174	regulation of phosphorus metabolic process	6.844047952474851e-20	6.844047952474851e-20	+1	TP53,PTEN,APC,KRAS,EGFR,NF1,PIK3R1,CDKN2A,RB1,NOTCH1,FBXW7,MAP3K1,FLT3,NPM1,IDH1,MAP2K4,STK11,CRIPAK,CEBPA,AKT1,BRAF,AR,PIK3CG,SOX9,CDKN1B,HGF,ERBB4,MTOR,TLR4,LRRK2,KIT,PDGFRA,FGFR2,CCND1,SMAD4,FOXA2,FGFR3,TGFBR2,CDKN1A,PPP2R1A,CDK12,PTPN11,MAPK8IP1,NSD1,ACVR2A,MECOM,NCOR1,AXIN2,CDKN2C,EZH2
GO:0071704	organic substance metabolic process	8.078977190102637e-20	8.078977190102637e-20	+1	TP53,PIK3CA,PTEN,APC,VHL,KRAS,ARID1A,PBRM1,EGFR,NF1,PIK3R1,CDKN2A,GATA3,RB1,NOTCH1,FBXW7,CTNNB1,DNMT3A,MAP3K1,FLT3,TSHZ3,KEAP1,CDH1,ARHGAP35,CTCF,NFE2L2,BAP1,NPM1,RUNX1,NRAS,IDH1,TBX3,MAP2K4,STK11,CRIPAK,CEBPA,KDM6A,EPHA3,AKT1,STAG2,BRAF,AR,AJUBA,TSHZ2,PIK3CG,SOX9,ATM,CDKN1B,WT1,HGF,KDM5C,PRX,ERBB4,MTOR,TLR4,U2AF1,ARID5B,TET2,ATRX,ELF3,BRCA1,LRRK2,POLQ,FOXA1,IDH2,CHEK2,KIT,HIST1H1C,SETD2,PDGFRA,EP300,FGFR2,CCND1,SMAD4,FOXA2,USP9X,BRCA2,NFE2L3,FGFR3,ASXL1,TGFBR2,SOX17,CDKN1A,B4GALT3,SF3B1,TAF1,PPP2R1A,CBFB,ATR,SIN3A,VEZF1,HIST1H2BD,EIF4A2,CDK12,PHF6,SMC1A,PTPN11,ACVR1B,MAPK8IP1,NSD1,TBL1XR1,EGR3,ACVR2A,MECOM,SMC3,NCOR1,RPL5,SMAD2,SPOP,AXIN2,RAD21,ERCC2,CDKN2C,EZH2,PCBP1
GO:0001932	regulation of protein phosphorylation	1.3261891585178153e-19	1.3261891585178153e-19	+1	TP53,PTEN,APC,KRAS,EGFR,NF1,CDKN2A,RB1,NOTCH1,FBXW7,MAP3K1,FLT3,NPM1,MAP2K4,STK11,CRIPAK,CEBPA,AKT1,BRAF,PIK3CG,SOX9,CDKN1B,HGF,ERBB4,MTOR,TLR4,LRRK2,KIT,PDGFRA,FGFR2,CCND1,SMAD4,FGFR3,TGFBR2,CDKN1A,PPP2R1A,CDK12,PTPN11,MAPK8IP1,NSD1,ACVR2A,MECOM,NCOR1,AXIN2,CDKN2C,EZH2
GO:0006807	nitrogen compound metabolic process	1.4475794401780676e-19	1.4475794401780676e-19	+1	TP53,PIK3CA,PTEN,APC,VHL,KRAS,ARID1A,PBRM1,EGFR,NF1,PIK3R1,CDKN2A,GATA3,RB1,NOTCH1,FBXW7,CTNNB1,DNMT3A,MAP3K1,FLT3,TSHZ3,KEAP1,CDH1,ARHGAP35,CTCF,NFE2L2,BAP1,NPM1,RUNX1,NRAS,TBX3,MAP2K4,STK11,CRIPAK,CEBPA,KDM6A,EPHA3,AKT1,BRAF,AR,TSHZ2,PIK3CG,SOX9,ATM,CDKN1B,WT1,HGF,KDM5C,PRX,ERBB4,MTOR,TLR4,U2AF1,ARID5B,TET2,ATRX,ELF3,BRCA1,LRRK2,POLQ,FOXA1,CHEK2,KIT,HIST1H1C,SETD2,PDGFRA,EP300,FGFR2,CCND1,SMAD4,FOXA2,USP9X,BRCA2,NFE2L3,FGFR3,ASXL1,TGFBR2,SOX17,CDKN1A,B4GALT3,SF3B1,TAF1,PPP2R1A,CBFB,ATR,SIN3A,VEZF1,HIST1H2BD,EIF4A2,CDK12,PHF6,SMC1A,PTPN11,ACVR1B,MAPK8IP1,NSD1,TBL1XR1,EGR3,ACVR2A,MECOM,NCOR1,RPL5,SMAD2,SPOP,AXIN2,RAD21,ERCC2,CDKN2C,EZH2,PCBP1
GO:0044249	cellular biosynthetic process	1.8248670628991095e-19	1.8248670628991095e-19	+1	TP53,PIK3CA,PTEN,VHL,ARID1A,PBRM1,EGFR,PIK3R1,CDKN2A,GATA3,RB1,NOTCH1,FBXW7,CTNNB1,DNMT3A,TSHZ3,KEAP1,CDH1,ARHGAP35,CTCF,NFE2L2,NPM1,RUNX1,IDH1,TBX3,CEBPA,AKT1,STAG2,AR,TSHZ2,PIK3CG,SOX9,ATM,CDKN1B,WT1,HGF,KDM5C,ERBB4,MTOR,TLR4,ARID5B,TET2,ATRX,ELF3,BRCA1,POLQ,FOXA1,CHEK2,KIT,HIST1H1C,SETD2,EP300,FGFR2,CCND1,SMAD4,FOXA2,USP9X,BRCA2,NFE2L3,ASXL1,SOX17,CDKN1A,B4GALT3,TAF1,PPP2R1A,CBFB,ATR,SIN3A,VEZF1,EIF4A2,CDK12,PHF6,SMC1A,ACVR1B,NSD1,TBL1XR1,EGR3,ACVR2A,MECOM,SMC3,NCOR1,RPL5,SMAD2,RAD21,ERCC2,EZH2
GO:2000113	negative regulation of cellular macromolecule biosynthetic process	2.1328557568124452e-19	2.1328557568124452e-19	+1	TP53,VHL,CDKN2A,GATA3,RB1,NOTCH1,FBXW7,CTNNB1,DNMT3A,TSHZ3,ARHGAP35,CTCF,RUNX1,TBX3,CEBPA,STAG2,AR,SOX9,CDKN1B,WT1,KDM5C,ARID5B,ATRX,ELF3,BRCA1,CHEK2,HIST1H1C,EP300,FGFR2,CCND1,SMAD4,USP9X,SOX17,TAF1,CBFB,ATR,SIN3A,PHF6,SMC1A,NSD1,TBL1XR1,MECOM,SMC3,NCOR1,SMAD2,EZH2
GO:0031327	negative regulation of cellular biosynthetic process	2.279651035207462e-19	2.279651035207462e-19	+1	TP53,VHL,CDKN2A,GATA3,RB1,NOTCH1,FBXW7,CTNNB1,DNMT3A,TSHZ3,ARHGAP35,CTCF,RUNX1,TBX3,CEBPA,STAG2,AR,SOX9,CDKN1B,WT1,KDM5C,ARID5B,ATRX,ELF3,BRCA1,CHEK2,HIST1H1C,EP300,FGFR2,CCND1,SMAD4,USP9X,SOX17,TAF1,CBFB,ATR,SIN3A,EIF4A2,PHF6,SMC1A,NSD1,TBL1XR1,MECOM,SMC3,NCOR1,SMAD2,EZH2
GO:0044237	cellular metabolic process	2.428200925889315e-19	2.428200925889315e-19	+1	TP53,PIK3CA,PTEN,APC,VHL,KRAS,ARID1A,PBRM1,EGFR,NF1,PIK3R1,CDKN2A,GATA3,RB1,NOTCH1,FBXW7,CTNNB1,DNMT3A,MAP3K1,FLT3,TSHZ3,KEAP1,CDH1,ARHGAP35,CTCF,NFE2L2,BAP1,NPM1,RUNX1,NRAS,IDH1,TBX3,MAP2K4,STK11,CRIPAK,CEBPA,KDM6A,EPHA3,AKT1,STAG2,BRAF,AR,TSHZ2,PIK3CG,SOX9,ATM,CDKN1B,WT1,HGF,KDM5C,PRX,ERBB4,MTOR,TLR4,U2AF1,ARID5B,TET2,ATRX,ELF3,BRCA1,LRRK2,POLQ,FOXA1,IDH2,CHEK2,KIT,HIST1H1C,SETD2,PDGFRA,EP300,FGFR2,CCND1,SMAD4,FOXA2,USP9X,BRCA2,NFE2L3,FGFR3,ASXL1,TGFBR2,SOX17,CDKN1A,B4GALT3,SF3B1,TAF1,PPP2R1A,CBFB,ATR,SIN3A,VEZF1,HIST1H2BD,EIF4A2,CDK12,PHF6,SMC1A,PTPN11,ACVR1B,MAPK8IP1,NSD1,TBL1XR1,EGR3,ACVR2A,MECOM,SMC3,NCOR1,RPL5,SMAD2,SPOP,AXIN2,RAD21,ERCC2,CDKN2C,EZH2,PCBP1
GO:0044238	primary metabolic process	2.6188487988162063e-19	2.6188487988162063e-19	+1	TP53,PIK3CA,PTEN,APC,VHL,KRAS,ARID1A,PBRM1,EGFR,NF1,PIK3R1,CDKN2A,GATA3,RB1,NOTCH1,FBXW7,CTNNB1,DNMT3A,MAP3K1,FLT3,TSHZ3,KEAP1,CDH1,ARHGAP35,CTCF,NFE2L2,BAP1,NPM1,RUNX1,NRAS,IDH1,TBX3,MAP2K4,STK11,CRIPAK,CEBPA,KDM6A,EPHA3,AKT1,BRAF,AR,TSHZ2,PIK3CG,SOX9,ATM,CDKN1B,WT1,HGF,KDM5C,PRX,ERBB4,MTOR,TLR4,U2AF1,ARID5B,TET2,ATRX,ELF3,BRCA1,LRRK2,POLQ,FOXA1,IDH2,CHEK2,KIT,HIST1H1C,SETD2,PDGFRA,EP300,FGFR2,CCND1,SMAD4,FOXA2,USP9X,BRCA2,NFE2L3,FGFR3,ASXL1,TGFBR2,SOX17,CDKN1A,B4GALT3,SF3B1,TAF1,PPP2R1A,CBFB,ATR,SIN3A,VEZF1,HIST1H2BD,EIF4A2,CDK12,PHF6,SMC1A,PTPN11,ACVR1B,MAPK8IP1,NSD1,TBL1XR1,EGR3,ACVR2A,MECOM,NCOR1,RPL5,SMAD2,SPOP,AXIN2,RAD21,ERCC2,CDKN2C,EZH2,PCBP1
GO:0009890	negative regulation of biosynthetic process	3.7049370515622033e-19	3.7049370515622033e-19	+1	TP53,VHL,CDKN2A,GATA3,RB1,NOTCH1,FBXW7,CTNNB1,DNMT3A,TSHZ3,ARHGAP35,CTCF,RUNX1,TBX3,CEBPA,STAG2,AR,SOX9,CDKN1B,WT1,KDM5C,ARID5B,ATRX,ELF3,BRCA1,CHEK2,HIST1H1C,EP300,FGFR2,CCND1,SMAD4,USP9X,SOX17,TAF1,CBFB,ATR,SIN3A,EIF4A2,PHF6,SMC1A,NSD1,TBL1XR1,MECOM,SMC3,NCOR1,SMAD2,EZH2
GO:1901576	organic substance biosynthetic process	5.314234384980494e-19	5.314234384980494e-19	+1	TP53,PIK3CA,PTEN,VHL,ARID1A,PBRM1,EGFR,PIK3R1,CDKN2A,GATA3,RB1,NOTCH1,FBXW7,CTNNB1,DNMT3A,TSHZ3,KEAP1,CDH1,ARHGAP35,CTCF,NFE2L2,NPM1,RUNX1,IDH1,TBX3,CEBPA,AKT1,STAG2,AR,TSHZ2,PIK3CG,SOX9,ATM,CDKN1B,WT1,HGF,KDM5C,ERBB4,MTOR,TLR4,ARID5B,TET2,ATRX,ELF3,BRCA1,POLQ,FOXA1,CHEK2,KIT,HIST1H1C,SETD2,EP300,FGFR2,CCND1,SMAD4,FOXA2,USP9X,BRCA2,NFE2L3,ASXL1,SOX17,CDKN1A,B4GALT3,TAF1,PPP2R1A,CBFB,ATR,SIN3A,VEZF1,EIF4A2,CDK12,PHF6,SMC1A,ACVR1B,NSD1,TBL1XR1,EGR3,ACVR2A,MECOM,SMC3,NCOR1,RPL5,SMAD2,RAD21,ERCC2,EZH2
GO:0034641	cellular nitrogen compound metabolic process	6.538059676029183e-19	6.538059676029183e-19	+1	TP53,PTEN,VHL,ARID1A,PBRM1,EGFR,PIK3R1,CDKN2A,GATA3,RB1,NOTCH1,FBXW7,CTNNB1,DNMT3A,TSHZ3,KEAP1,CDH1,ARHGAP35,CTCF,NFE2L2,NPM1,RUNX1,TBX3,CRIPAK,CEBPA,AKT1,AR,TSHZ2,SOX9,ATM,CDKN1B,WT1,HGF,KDM5C,PRX,ERBB4,MTOR,TLR4,U2AF1,ARID5B,TET2,ATRX,ELF3,BRCA1,LRRK2,POLQ,FOXA1,CHEK2,KIT,HIST1H1C,SETD2,EP300,FGFR2,CCND1,SMAD4,FOXA2,USP9X,BRCA2,NFE2L3,ASXL1,SOX17,CDKN1A,B4GALT3,SF3B1,TAF1,PPP2R1A,CBFB,ATR,SIN3A,VEZF1,EIF4A2,CDK12,PHF6,SMC1A,ACVR1B,NSD1,TBL1XR1,EGR3,ACVR2A,MECOM,NCOR1,RPL5,SMAD2,AXIN2,RAD21,ERCC2,EZH2,PCBP1
GO:0045934	negative regulation of nucleobase-containing compound metabolic process	9.428939046627086e-19	9.428939046627086e-19	+1	TP53,VHL,CDKN2A,GATA3,RB1,NOTCH1,CTNNB1,DNMT3A,TSHZ3,ARHGAP35,CTCF,RUNX1,TBX3,CEBPA,AR,SOX9,ATM,CDKN1B,WT1,KDM5C,ARID5B,ATRX,ELF3,BRCA1,POLQ,HIST1H1C,EP300,FGFR2,CCND1,SMAD4,USP9X,SOX17,TAF1,CBFB,SIN3A,EIF4A2,PHF6,NSD1,TBL1XR1,MECOM,NCOR1,SMAD2,AXIN2,EZH2
GO:0009058	biosynthetic process	1.220395129520998e-18	1.220395129520998e-18	+1	TP53,PIK3CA,PTEN,VHL,ARID1A,PBRM1,EGFR,PIK3R1,CDKN2A,GATA3,RB1,NOTCH1,FBXW7,CTNNB1,DNMT3A,TSHZ3,KEAP1,CDH1,ARHGAP35,CTCF,NFE2L2,NPM1,RUNX1,IDH1,TBX3,CEBPA,AKT1,STAG2,AR,TSHZ2,PIK3CG,SOX9,ATM,CDKN1B,WT1,HGF,KDM5C,ERBB4,MTOR,TLR4,ARID5B,TET2,ATRX,ELF3,BRCA1,POLQ,FOXA1,CHEK2,KIT,HIST1H1C,SETD2,EP300,FGFR2,CCND1,SMAD4,FOXA2,USP9X,BRCA2,NFE2L3,ASXL1,SOX17,CDKN1A,B4GALT3,TAF1,PPP2R1A,CBFB,ATR,SIN3A,VEZF1,EIF4A2,CDK12,PHF6,SMC1A,ACVR1B,NSD1,TBL1XR1,EGR3,ACVR2A,MECOM,SMC3,NCOR1,RPL5,SMAD2,RAD21,ERCC2,EZH2
GO:1903507	negative regulation of nucleic acid-templated transcription	1.3644450922649437e-18	1.3644450922649437e-18	+1	TP53,VHL,CDKN2A,GATA3,RB1,NOTCH1,CTNNB1,DNMT3A,TSHZ3,ARHGAP35,CTCF,RUNX1,TBX3,CEBPA,AR,SOX9,CDKN1B,WT1,KDM5C,ARID5B,ATRX,ELF3,BRCA1,HIST1H1C,EP300,FGFR2,CCND1,SMAD4,USP9X,SOX17,TAF1,CBFB,SIN3A,EIF4A2,PHF6,NSD1,TBL1XR1,MECOM,NCOR1,SMAD2,EZH2
GO:1902679	negative regulation of RNA biosynthetic process	1.4005789334034608e-18	1.4005789334034608e-18	+1	TP53,VHL,CDKN2A,GATA3,RB1,NOTCH1,CTNNB1,DNMT3A,TSHZ3,ARHGAP35,CTCF,RUNX1,TBX3,CEBPA,AR,SOX9,CDKN1B,WT1,KDM5C,ARID5B,ATRX,ELF3,BRCA1,HIST1H1C,EP300,FGFR2,CCND1,SMAD4,USP9X,SOX17,TAF1,CBFB,SIN3A,EIF4A2,PHF6,NSD1,TBL1XR1,MECOM,NCOR1,SMAD2,EZH2
GO:0051246	regulation of protein metabolic process	3.095983394612304e-18	3.095983394612304e-18	+1	TP53,PTEN,APC,KRAS,EGFR,NF1,CDKN2A,GATA3,RB1,NOTCH1,FBXW7,CTNNB1,MAP3K1,FLT3,KEAP1,NFE2L2,NPM1,MAP2K4,STK11,CRIPAK,CEBPA,AKT1,BRAF,PIK3CG,SOX9,CDKN1B,HGF,ERBB4,MTOR,TLR4,ATRX,BRCA1,LRRK2,CHEK2,KIT,PDGFRA,EP300,FGFR2,CCND1,SMAD4,FGFR3,TGFBR2,CDKN1A,TAF1,PPP2R1A,SIN3A,EIF4A2,CDK12,PTPN11,MAPK8IP1,NSD1,ACVR2A,MECOM,NCOR1,RPL5,SPOP,AXIN2,CDKN2C,EZH2
GO:0051253	negative regulation of RNA metabolic process	3.1799797966745227e-18	3.1799797966745227e-18	+1	TP53,VHL,CDKN2A,GATA3,RB1,NOTCH1,CTNNB1,DNMT3A,TSHZ3,ARHGAP35,CTCF,RUNX1,TBX3,CEBPA,AR,SOX9,CDKN1B,WT1,KDM5C,ARID5B,ATRX,ELF3,BRCA1,HIST1H1C,EP300,FGFR2,CCND1,SMAD4,USP9X,SOX17,TAF1,CBFB,SIN3A,EIF4A2,PHF6,NSD1,TBL1XR1,MECOM,NCOR1,SMAD2,AXIN2,EZH2
GO:0042127	regulation of cell population proliferation	3.818006617820829e-18	3.818006617820829e-18	+1	TP53,PTEN,APC,VHL,KRAS,PBRM1,EGFR,NF1,CDKN2A,GATA3,NOTCH1,FBXW7,CTNNB1,FLT3,CTCF,BAP1,NPM1,NRAS,TBX3,STK11,CEBPA,AKT1,AR,EPPK1,SOX9,ATM,CDKN1B,WT1,ERBB4,BRCA1,LRRK2,KIT,PDGFRA,FGFR2,CCND1,BRCA2,FGFR3,TGFBR2,CDKN1A,MAPK8IP1,EGR3,LIFR,AXIN2,CDKN2C,EZH2
GO:0050794	regulation of cellular process	6.523301270017696e-18	6.523301270017696e-18	+1	TP53,PIK3CA,PTEN,APC,VHL,KRAS,ARID1A,PBRM1,NAV3,EGFR,NF1,PIK3R1,CDKN2A,GATA3,RB1,NOTCH1,FBXW7,CTNNB1,DNMT3A,MAP3K1,FLT3,TSHZ3,KEAP1,CDH1,ARHGAP35,CTCF,NFE2L2,BAP1,NPM1,RUNX1,NRAS,IDH1,TBX3,MAP2K4,STK11,CRIPAK,CEBPA,EPHA3,AKT1,STAG2,BRAF,AR,AJUBA,EPPK1,TSHZ2,PIK3CG,SOX9,ATM,CDKN1B,WT1,HGF,KDM5C,PRX,ERBB4,MTOR,TLR4,ARID5B,TET2,ATRX,ELF3,BRCA1,LRRK2,POLQ,FOXA1,CHEK2,KIT,HIST1H1C,SETD2,PDGFRA,EP300,FGFR2,CCND1,SMAD4,FOXA2,USP9X,BRCA2,NFE2L3,FGFR3,ASXL1,TGFBR2,SOX17,CDKN1A,TAF1,PPP2R1A,CBFB,ATR,SIN3A,VEZF1,EIF4A2,CDK12,PHF6,SMC1A,PTPN11,ACVR1B,MAPK8IP1,H3F3C,NSD1,TBL1XR1,EGR3,ACVR2A,MECOM,LIFR,SMC3,NCOR1,RPL5,SMAD2,AXIN2,MIR142,RAD21,ERCC2,CDKN2C,EZH2
GO:0045892	negative regulation of transcription, DNA-templated	9.193758912645974e-18	9.193758912645974e-18	+1	TP53,VHL,CDKN2A,GATA3,RB1,NOTCH1,CTNNB1,DNMT3A,TSHZ3,ARHGAP35,CTCF,RUNX1,TBX3,CEBPA,AR,SOX9,CDKN1B,WT1,KDM5C,ARID5B,ATRX,ELF3,BRCA1,HIST1H1C,EP300,FGFR2,CCND1,SMAD4,USP9X,SOX17,TAF1,CBFB,SIN3A,PHF6,NSD1,TBL1XR1,MECOM,NCOR1,SMAD2,EZH2
GO:0008152	metabolic process	1.2115370738679883e-17	1.2115370738679883e-17	+1	TP53,PIK3CA,PTEN,APC,VHL,KRAS,ARID1A,PBRM1,EGFR,NF1,PIK3R1,CDKN2A,GATA3,RB1,NOTCH1,FBXW7,CTNNB1,DNMT3A,MAP3K1,FLT3,TSHZ3,KEAP1,CDH1,ARHGAP35,CTCF,NFE2L2,BAP1,NPM1,RUNX1,NRAS,IDH1,TBX3,MAP2K4,STK11,CRIPAK,CEBPA,KDM6A,EPHA3,AKT1,STAG2,BRAF,AR,AJUBA,TSHZ2,PIK3CG,SOX9,ATM,CDKN1B,WT1,HGF,KDM5C,PRX,ERBB4,MTOR,TLR4,U2AF1,ARID5B,TET2,ATRX,ELF3,BRCA1,LRRK2,POLQ,FOXA1,IDH2,CHEK2,KIT,HIST1H1C,SETD2,PDGFRA,EP300,FGFR2,CCND1,SMAD4,FOXA2,USP9X,BRCA2,NFE2L3,FGFR3,ASXL1,TGFBR2,SOX17,CDKN1A,B4GALT3,SF3B1,TAF1,PPP2R1A,CBFB,ATR,SIN3A,VEZF1,HIST1H2BD,EIF4A2,CDK12,PHF6,SMC1A,PTPN11,ACVR1B,MAPK8IP1,NSD1,TBL1XR1,EGR3,ACVR2A,MECOM,SMC3,NCOR1,RPL5,SMAD2,SPOP,AXIN2,RAD21,ERCC2,CDKN2C,EZH2,PCBP1
GO:0051338	regulation of transferase activity	2.906161584859614e-17	2.906161584859614e-17	+1	TP53,PTEN,APC,EGFR,NF1,PIK3R1,CDKN2A,RB1,FBXW7,MAP3K1,FLT3,NPM1,MAP2K4,STK11,CRIPAK,CEBPA,AKT1,PIK3CG,CDKN1B,MTOR,TLR4,LRRK2,KIT,PDGFRA,CCND1,FOXA2,FGFR3,TGFBR2,CDKN1A,PPP2R1A,EIF4A2,CDK12,MAPK8IP1,RPL5,CDKN2C,EZH2
GO:0032268	regulation of cellular protein metabolic process	2.906161584859614e-17	2.906161584859614e-17	+1	TP53,PTEN,APC,KRAS,EGFR,NF1,CDKN2A,RB1,NOTCH1,FBXW7,CTNNB1,MAP3K1,FLT3,KEAP1,NFE2L2,NPM1,MAP2K4,STK11,CRIPAK,CEBPA,AKT1,BRAF,PIK3CG,SOX9,CDKN1B,HGF,ERBB4,MTOR,TLR4,ATRX,BRCA1,LRRK2,KIT,PDGFRA,EP300,FGFR2,CCND1,SMAD4,FGFR3,TGFBR2,CDKN1A,TAF1,PPP2R1A,SIN3A,EIF4A2,CDK12,PTPN11,MAPK8IP1,NSD1,ACVR2A,MECOM,NCOR1,RPL5,AXIN2,CDKN2C,EZH2
GO:0051726	regulation of cell cycle	3.3871220698437383e-17	3.3871220698437383e-17	+1	TP53,PTEN,APC,CDKN2A,GATA3,RB1,NOTCH1,FBXW7,CTNNB1,CTCF,BAP1,NPM1,TBX3,STK11,CEBPA,STAG2,SOX9,ATM,CDKN1B,MTOR,ATRX,BRCA1,FOXA1,CHEK2,SETD2,EP300,FGFR2,CCND1,CDKN1A,TAF1,PPP2R1A,ATR,SMC1A,MECOM,SMC3,AXIN2,RAD21,ERCC2,CDKN2C,EZH2
GO:0044267	cellular protein metabolic process	4.0285451367133404e-17	4.0285451367133404e-17	+1	TP53,PIK3CA,PTEN,APC,VHL,KRAS,EGFR,NF1,CDKN2A,GATA3,RB1,NOTCH1,FBXW7,CTNNB1,MAP3K1,FLT3,KEAP1,NFE2L2,BAP1,NPM1,NRAS,MAP2K4,STK11,CRIPAK,CEBPA,KDM6A,EPHA3,AKT1,BRAF,AR,PIK3CG,SOX9,ATM,CDKN1B,HGF,KDM5C,ERBB4,MTOR,TLR4,TET2,ATRX,BRCA1,LRRK2,CHEK2,KIT,HIST1H1C,SETD2,PDGFRA,EP300,FGFR2,CCND1,SMAD4,USP9X,BRCA2,FGFR3,ASXL1,TGFBR2,CDKN1A,TAF1,PPP2R1A,CBFB,ATR,SIN3A,HIST1H2BD,EIF4A2,CDK12,PTPN11,ACVR1B,MAPK8IP1,NSD1,TBL1XR1,ACVR2A,MECOM,NCOR1,RPL5,SMAD2,SPOP,AXIN2,CDKN2C,EZH2
GO:0009966	regulation of signal transduction	8.869208398207959e-17	8.869208398207959e-17	+1	TP53,PIK3CA,PTEN,APC,VHL,EGFR,NF1,PIK3R1,GATA3,NOTCH1,FBXW7,CTNNB1,FLT3,ARHGAP35,NFE2L2,RUNX1,MAP2K4,STK11,CRIPAK,AKT1,BRAF,AR,AJUBA,PIK3CG,SOX9,ATM,HGF,ERBB4,TLR4,ELF3,BRCA1,LRRK2,FOXA1,CHEK2,KIT,PDGFRA,EP300,FGFR2,SMAD4,FGFR3,ASXL1,TGFBR2,SOX17,TAF1,PPP2R1A,CBFB,ATR,CDK12,PTPN11,ACVR1B,MAPK8IP1,TBL1XR1,ACVR2A,MECOM,LIFR,NCOR1,RPL5,SMAD2,AXIN2,EZH2
GO:0010629	negative regulation of gene expression	1.0927769947202375e-16	1.0927769947202375e-16	+1	TP53,VHL,EGFR,CDKN2A,GATA3,RB1,NOTCH1,FBXW7,CTNNB1,DNMT3A,TSHZ3,ARHGAP35,CTCF,NPM1,RUNX1,TBX3,CEBPA,AKT1,AR,AJUBA,SOX9,ATM,CDKN1B,WT1,KDM5C,ARID5B,ATRX,ELF3,BRCA1,LRRK2,HIST1H1C,EP300,FGFR2,CCND1,SMAD4,USP9X,SOX17,TAF1,PPP2R1A,CBFB,SIN3A,PHF6,NSD1,TBL1XR1,MECOM,NCOR1,RPL5,SMAD2,AXIN2,EZH2
GO:0008283	cell population proliferation	1.1814009626540866e-16	1.1814009626540866e-16	+1	TP53,PTEN,APC,VHL,KRAS,PBRM1,EGFR,NF1,CDKN2A,GATA3,NOTCH1,FBXW7,CTNNB1,FLT3,CTCF,BAP1,NPM1,RUNX1,NRAS,TBX3,STK11,CEBPA,AKT1,AR,EPPK1,PIK3CG,SOX9,ATM,CDKN1B,WT1,ERBB4,BRCA1,LRRK2,KIT,PDGFRA,FGFR2,CCND1,BRCA2,FGFR3,TGFBR2,CDKN1A,MAPK8IP1,EGR3,MECOM,LIFR,AXIN2,CDKN2C,EZH2
GO:0051128	regulation of cellular component organization	1.3224541180564766e-16	1.3224541180564766e-16	+1	TP53,PTEN,APC,NAV3,EGFR,CDKN2A,RB1,NOTCH1,FBXW7,CTNNB1,ARHGAP35,CTCF,BAP1,NPM1,RUNX1,STK11,CRIPAK,EPHA3,AKT1,STAG2,AR,AJUBA,ATM,CDKN1B,WT1,HGF,MTOR,TLR4,ATRX,BRCA1,LRRK2,KIT,HIST1H1C,PDGFRA,EP300,CCND1,SMAD4,SOX17,CDKN1A,PPP2R1A,CBFB,ATR,SIN3A,SMC1A,PTPN11,ACVR1B,H3F3C,NSD1,SMC3,AXIN2,RAD21,ERCC2,CDKN2C
GO:0050789	regulation of biological process	1.4356377098785291e-16	1.4356377098785291e-16	+1	TP53,PIK3CA,PTEN,APC,VHL,KRAS,ARID1A,PBRM1,NAV3,EGFR,NF1,PIK3R1,CDKN2A,GATA3,RB1,NOTCH1,FBXW7,CTNNB1,DNMT3A,MAP3K1,FLT3,TSHZ3,KEAP1,CDH1,ARHGAP35,CTCF,NFE2L2,BAP1,NPM1,RUNX1,NRAS,IDH1,TBX3,MAP2K4,STK11,CRIPAK,CEBPA,EPHA3,AKT1,STAG2,BRAF,AR,AJUBA,EPPK1,TSHZ2,PIK3CG,SOX9,ATM,CDKN1B,WT1,HGF,KDM5C,PRX,ERBB4,MTOR,TLR4,ARID5B,TET2,ATRX,ELF3,BRCA1,LRRK2,POLQ,FOXA1,CHEK2,KIT,HIST1H1C,SETD2,PDGFRA,EP300,FGFR2,CCND1,SMAD4,FOXA2,USP9X,BRCA2,NFE2L3,FGFR3,ASXL1,TGFBR2,SOX17,CDKN1A,SF3B1,TAF1,PPP2R1A,CBFB,ATR,SIN3A,VEZF1,EIF4A2,CDK12,PHF6,SMC1A,PTPN11,ACVR1B,MAPK8IP1,H3F3C,NSD1,TBL1XR1,EGR3,ACVR2A,MECOM,LIFR,SMC3,NCOR1,RPL5,SMAD2,SPOP,AXIN2,MIR142,RAD21,ERCC2,CDKN2C,EZH2
GO:0045944	positive regulation of transcription by RNA polymerase II	1.647006537911751e-16	1.647006537911751e-16	+1	TP53,EGFR,PIK3R1,CDKN2A,GATA3,NOTCH1,FBXW7,CTNNB1,CTCF,NFE2L2,NPM1,RUNX1,CEBPA,AR,SOX9,ATM,WT1,HGF,TLR4,TET2,ATRX,BRCA1,FOXA1,EP300,FGFR2,SMAD4,FOXA2,ASXL1,SOX17,TAF1,SIN3A,VEZF1,CDK12,TBL1XR1,EGR3,ACVR2A,SMAD2,ERCC2
GO:0007049	cell cycle	1.7917665674304997e-16	1.7917665674304997e-16	+1	TP53,PTEN,APC,PBRM1,CDKN2A,GATA3,RB1,NOTCH1,FBXW7,CTNNB1,CTCF,BAP1,NPM1,TBX3,STK11,CEBPA,STAG2,AJUBA,SOX9,ATM,CDKN1B,HGF,MTOR,ATRX,BRCA1,FOXA1,CHEK2,SETD2,EP300,FGFR2,CCND1,BRCA2,CDKN1A,TAF1,PPP2R1A,ATR,SMC1A,ACVR1B,MECOM,SMC3,NCOR1,AXIN2,RAD21,ERCC2,CDKN2C,EZH2
GO:0043549	regulation of kinase activity	2.7240061131278414e-16	2.7240061131278414e-16	+1	PTEN,APC,EGFR,NF1,PIK3R1,CDKN2A,RB1,FBXW7,MAP3K1,FLT3,NPM1,MAP2K4,STK11,CRIPAK,CEBPA,AKT1,PIK3CG,CDKN1B,MTOR,TLR4,LRRK2,KIT,PDGFRA,CCND1,FOXA2,FGFR3,TGFBR2,CDKN1A,PPP2R1A,CDK12,MAPK8IP1,CDKN2C,EZH2
GO:0010646	regulation of cell communication	2.98053881522495e-16	2.98053881522495e-16	+1	TP53,PIK3CA,PTEN,APC,VHL,EGFR,NF1,PIK3R1,GATA3,NOTCH1,FBXW7,CTNNB1,FLT3,TSHZ3,ARHGAP35,NFE2L2,RUNX1,MAP2K4,STK11,CRIPAK,AKT1,BRAF,AR,AJUBA,PIK3CG,SOX9,ATM,HGF,ERBB4,TLR4,ELF3,BRCA1,LRRK2,FOXA1,CHEK2,KIT,PDGFRA,EP300,FGFR2,SMAD4,FOXA2,FGFR3,ASXL1,TGFBR2,SOX17,TAF1,PPP2R1A,CBFB,ATR,CDK12,PTPN11,ACVR1B,MAPK8IP1,TBL1XR1,ACVR2A,MECOM,LIFR,NCOR1,RPL5,SMAD2,AXIN2,EZH2
GO:0023051	regulation of signaling	5.387993938488715e-16	5.387993938488715e-16	+1	TP53,PIK3CA,PTEN,APC,VHL,EGFR,NF1,PIK3R1,GATA3,NOTCH1,FBXW7,CTNNB1,FLT3,TSHZ3,ARHGAP35,NFE2L2,RUNX1,MAP2K4,STK11,CRIPAK,AKT1,BRAF,AR,AJUBA,PIK3CG,SOX9,ATM,HGF,ERBB4,TLR4,ELF3,BRCA1,LRRK2,FOXA1,CHEK2,KIT,PDGFRA,EP300,FGFR2,SMAD4,FOXA2,FGFR3,ASXL1,TGFBR2,SOX17,TAF1,PPP2R1A,CBFB,ATR,CDK12,PTPN11,ACVR1B,MAPK8IP1,TBL1XR1,ACVR2A,MECOM,LIFR,NCOR1,RPL5,SMAD2,AXIN2,EZH2
GO:0051276	chromosome organization	5.628568123342705e-16	5.628568123342705e-16	+1	TP53,APC,ARID1A,PBRM1,CDKN2A,RB1,FBXW7,CTNNB1,CTCF,BAP1,NPM1,KDM6A,STAG2,SOX9,ATM,KDM5C,TET2,ATRX,BRCA1,FOXA1,HIST1H1C,SETD2,EP300,SMAD4,BRCA2,ASXL1,ATR,SIN3A,HIST1H2BD,SMC1A,H3F3C,NSD1,TBL1XR1,SMC3,AXIN2,RAD21,ERCC2,EZH2
GO:0048513	animal organ development	2.2924445035259205e-15	2.2924445035259205e-15	+1	PTEN,EGFR,NF1,CDKN2A,GATA3,RB1,NOTCH1,FBXW7,CTNNB1,FLT3,ARHGAP35,RUNX1,TBX3,CEBPA,EPHA3,AKT1,BRAF,AR,SOX9,ATM,CDKN1B,WT1,HGF,ERBB4,MTOR,TLR4,ARID5B,TET2,ELF3,LRRK2,FOXA1,KIT,PDGFRA,EP300,FGFR2,SMAD4,FOXA2,BRCA2,FGFR3,ASXL1,TGFBR2,SOX17,CDKN1A,TAF1,CBFB,SIN3A,PTPN11,ACVR1B,EGR3,ACVR2A,MECOM,SMAD2,AXIN2,EZH2
GO:0007275	multicellular organism development	2.665490263909691e-15	2.665490263909691e-15	+1	TP53,PIK3CA,PTEN,APC,NAV3,EGFR,NF1,PIK3R1,CDKN2A,GATA3,RB1,NOTCH1,FBXW7,CTNNB1,FLT3,CDH1,ARHGAP35,RUNX1,TBX3,STK11,CEBPA,EPHA3,AKT1,BRAF,AR,SOX9,ATM,CDKN1B,WT1,HGF,PRX,ERBB4,MTOR,TLR4,ARID5B,TET2,ELF3,BRCA1,LRRK2,POLQ,FOXA1,KIT,SETD2,PDGFRA,EP300,FGFR2,SMAD4,FOXA2,USP9X,BRCA2,FGFR3,ASXL1,TGFBR2,SOX17,CDKN1A,TAF1,CBFB,ATR,SIN3A,VEZF1,PTPN11,ACVR1B,EGR3,ACVR2A,MECOM,SMAD2,AXIN2,MIR142,ERCC2,EZH2
GO:0009719	response to endogenous stimulus	4.8876222330340505e-15	4.8876222330340505e-15	+1	TP53,PIK3CA,APC,ARID1A,EGFR,PIK3R1,GATA3,RB1,NOTCH1,CTNNB1,CDH1,RUNX1,IDH1,STK11,CRIPAK,AKT1,AR,SOX9,WT1,MTOR,TLR4,BRCA1,LRRK2,FOXA1,EP300,FGFR2,CCND1,SMAD4,USP9X,FGFR3,TGFBR2,TAF1,CBFB,SMC1A,PTPN11,ACVR1B,EGR3,ACVR2A,NCOR1,SMAD2
GO:0000122	negative regulation of transcription by RNA polymerase II	7.208436833483446e-15	7.208436833483446e-15	+1	TP53,VHL,RB1,NOTCH1,DNMT3A,ARHGAP35,CTCF,RUNX1,TBX3,AR,SOX9,WT1,ARID5B,ATRX,HIST1H1C,EP300,FGFR2,CCND1,SMAD4,USP9X,SOX17,TAF1,CBFB,SIN3A,PHF6,NSD1,TBL1XR1,NCOR1,SMAD2,EZH2
GO:0006796	phosphate-containing compound metabolic process	8.151558608616517e-15	8.151558608616517e-15	+1	TP53,PIK3CA,PTEN,APC,KRAS,EGFR,NF1,PIK3R1,CDKN2A,RB1,NOTCH1,FBXW7,MAP3K1,FLT3,NPM1,NRAS,IDH1,MAP2K4,STK11,CRIPAK,CEBPA,EPHA3,AKT1,BRAF,AR,PIK3CG,SOX9,ATM,CDKN1B,HGF,ERBB4,MTOR,TLR4,LRRK2,CHEK2,KIT,PDGFRA,FGFR2,CCND1,SMAD4,FOXA2,FGFR3,TGFBR2,CDKN1A,TAF1,PPP2R1A,ATR,CDK12,PTPN11,ACVR1B,MAPK8IP1,NSD1,ACVR2A,MECOM,NCOR1,SMAD2,AXIN2,CDKN2C,EZH2
GO:0019538	protein metabolic process	8.151558608616517e-15	8.151558608616517e-15	+1	TP53,PIK3CA,PTEN,APC,VHL,KRAS,EGFR,NF1,CDKN2A,GATA3,RB1,NOTCH1,FBXW7,CTNNB1,MAP3K1,FLT3,KEAP1,NFE2L2,BAP1,NPM1,NRAS,MAP2K4,STK11,CRIPAK,CEBPA,KDM6A,EPHA3,AKT1,BRAF,AR,PIK3CG,SOX9,ATM,CDKN1B,HGF,KDM5C,ERBB4,MTOR,TLR4,TET2,ATRX,BRCA1,LRRK2,CHEK2,KIT,HIST1H1C,SETD2,PDGFRA,EP300,FGFR2,CCND1,SMAD4,USP9X,BRCA2,FGFR3,ASXL1,TGFBR2,CDKN1A,TAF1,PPP2R1A,CBFB,ATR,SIN3A,HIST1H2BD,EIF4A2,CDK12,PTPN11,ACVR1B,MAPK8IP1,NSD1,TBL1XR1,ACVR2A,MECOM,NCOR1,RPL5,SMAD2,SPOP,AXIN2,CDKN2C,EZH2
GO:0071495	cellular response to endogenous stimulus	1.0507543859161232e-14	1.0507543859161232e-14	+1	TP53,PIK3CA,APC,ARID1A,EGFR,PIK3R1,GATA3,RB1,NOTCH1,CTNNB1,CDH1,RUNX1,STK11,CRIPAK,AKT1,AR,SOX9,WT1,MTOR,TLR4,BRCA1,LRRK2,FOXA1,EP300,FGFR2,SMAD4,USP9X,FGFR3,TGFBR2,TAF1,CBFB,SMC1A,PTPN11,ACVR1B,EGR3,ACVR2A,NCOR1,SMAD2
GO:0006793	phosphorus metabolic process	1.2845857929029663e-14	1.2845857929029663e-14	+1	TP53,PIK3CA,PTEN,APC,KRAS,EGFR,NF1,PIK3R1,CDKN2A,RB1,NOTCH1,FBXW7,MAP3K1,FLT3,NPM1,NRAS,IDH1,MAP2K4,STK11,CRIPAK,CEBPA,EPHA3,AKT1,BRAF,AR,PIK3CG,SOX9,ATM,CDKN1B,HGF,ERBB4,MTOR,TLR4,LRRK2,CHEK2,KIT,PDGFRA,FGFR2,CCND1,SMAD4,FOXA2,FGFR3,TGFBR2,CDKN1A,TAF1,PPP2R1A,ATR,CDK12,PTPN11,ACVR1B,MAPK8IP1,NSD1,ACVR2A,MECOM,NCOR1,SMAD2,AXIN2,CDKN2C,EZH2
GO:0050793	regulation of developmental process	1.4781955030187027e-14	1.4781955030187027e-14	+1	PTEN,APC,VHL,EGFR,NF1,CDKN2A,GATA3,RB1,NOTCH1,FBXW7,CTNNB1,ARHGAP35,RUNX1,TBX3,EPHA3,AKT1,AR,EPPK1,SOX9,CDKN1B,WT1,HGF,ERBB4,MTOR,TLR4,BRCA1,LRRK2,FOXA1,KIT,PDGFRA,EP300,FGFR2,SMAD4,FOXA2,BRCA2,FGFR3,ASXL1,TGFBR2,SOX17,CDKN1A,PPP2R1A,CBFB,SIN3A,VEZF1,ACVR1B,ACVR2A,SMAD2,AXIN2,MIR142,EZH2
GO:0048869	cellular developmental process	2.0663817663384315e-14	2.0663817663384315e-14	+1	TP53,PIK3CA,PTEN,APC,VHL,EGFR,NF1,PIK3R1,CDKN2A,GATA3,RB1,NOTCH1,FBXW7,CTNNB1,FLT3,CDH1,ARHGAP35,NPM1,RUNX1,TBX3,CEBPA,EPHA3,AKT1,AR,SOX9,ATM,WT1,HGF,ERBB4,MTOR,TLR4,TET2,ELF3,LRRK2,FOXA1,CHEK2,KIT,SETD2,PDGFRA,EP300,FGFR2,SMAD4,FOXA2,USP9X,FGFR3,ASXL1,TGFBR2,SOX17,CDKN1A,PPP2R1A,CBFB,ATR,SIN3A,VEZF1,PTPN11,ACVR1B,ACVR2A,SMAD2,AXIN2,MIR142,ERCC2,EZH2
GO:0051247	positive regulation of protein metabolic process	2.2940073572392687e-14	2.2940073572392687e-14	+1	TP53,PTEN,APC,KRAS,EGFR,CDKN2A,NOTCH1,FBXW7,CTNNB1,MAP3K1,FLT3,KEAP1,NFE2L2,NPM1,MAP2K4,STK11,CEBPA,AKT1,BRAF,PIK3CG,SOX9,CDKN1B,HGF,ERBB4,MTOR,TLR4,BRCA1,LRRK2,KIT,PDGFRA,FGFR2,CCND1,SMAD4,FGFR3,TGFBR2,CDKN1A,TAF1,PTPN11,MAPK8IP1,ACVR2A,RPL5,AXIN2,EZH2
GO:0048584	positive regulation of response to stimulus	2.3663004364544806e-14	2.3663004364544806e-14	+1	TP53,PIK3CA,PTEN,KRAS,EGFR,PIK3R1,CDKN2A,GATA3,NOTCH1,FBXW7,MAP3K1,FLT3,NFE2L2,RUNX1,NRAS,MAP2K4,STK11,CEBPA,AKT1,BRAF,PIK3CG,SOX9,ATM,HGF,ERBB4,MTOR,TLR4,ELF3,BRCA1,LRRK2,FOXA1,KIT,PDGFRA,EP300,FGFR2,SMAD4,FGFR3,ASXL1,TAF1,CBFB,ATR,SIN3A,PTPN11,ACVR1B,MAPK8IP1,TBL1XR1,ACVR2A,SMAD2,AXIN2,MIR142,EZH2
GO:0045595	regulation of cell differentiation	2.818433114737281e-14	2.818433114737281e-14	+1	PTEN,APC,VHL,EGFR,NF1,CDKN2A,GATA3,RB1,NOTCH1,FBXW7,CTNNB1,ARHGAP35,RUNX1,TBX3,EPHA3,AKT1,AR,SOX9,HGF,MTOR,TLR4,LRRK2,FOXA1,KIT,PDGFRA,EP300,FGFR2,SMAD4,FOXA2,ASXL1,TGFBR2,PPP2R1A,CBFB,SIN3A,VEZF1,ACVR1B,ACVR2A,SMAD2,AXIN2,MIR142,EZH2
GO:0018193	peptidyl-amino acid modification	3.2395793290636767e-14	3.2395793290636767e-14	+1	TP53,EGFR,CDKN2A,FBXW7,CTNNB1,FLT3,KDM6A,EPHA3,AKT1,BRAF,ATM,HGF,ERBB4,MTOR,TET2,ATRX,BRCA1,LRRK2,KIT,HIST1H1C,SETD2,PDGFRA,EP300,FGFR2,SMAD4,BRCA2,FGFR3,TGFBR2,TAF1,PPP2R1A,ATR,SIN3A,ACVR1B,NSD1,EZH2
GO:0010033	response to organic substance	4.052581597390742e-14	4.052581597390742e-14	+1	TP53,PIK3CA,APC,ARID1A,EGFR,PIK3R1,GATA3,RB1,NOTCH1,CTNNB1,FLT3,CDH1,NFE2L2,NPM1,RUNX1,IDH1,STK11,CRIPAK,CEBPA,EPHA3,AKT1,AR,SOX9,ATM,WT1,HGF,MTOR,TLR4,ATRX,BRCA1,LRRK2,FOXA1,KIT,SETD2,PDGFRA,EP300,FGFR2,CCND1,SMAD4,FOXA2,USP9X,FGFR3,ASXL1,TGFBR2,CDKN1A,TAF1,PPP2R1A,CBFB,PTPN11,ACVR1B,EGR3,ACVR2A,LIFR,NCOR1,SMAD2
GO:0070887	cellular response to chemical stimulus	4.052581597390742e-14	4.052581597390742e-14	+1	TP53,PIK3CA,APC,VHL,ARID1A,EGFR,PIK3R1,GATA3,RB1,NOTCH1,FBXW7,CTNNB1,FLT3,CDH1,NFE2L2,NPM1,RUNX1,STK11,CRIPAK,CEBPA,EPHA3,AKT1,BRAF,AR,AJUBA,PIK3CG,SOX9,ATM,CDKN1B,WT1,HGF,MTOR,TLR4,ATRX,BRCA1,LRRK2,FOXA1,KIT,PDGFRA,EP300,FGFR2,CCND1,SMAD4,FOXA2,USP9X,FGFR3,TGFBR2,CDKN1A,TAF1,CBFB,PTPN11,ACVR1B,EGR3,ACVR2A,LIFR,NCOR1,SMAD2
GO:0065009	regulation of molecular function	5.1680498728239885e-14	5.1680498728239885e-14	+1	TP53,PTEN,APC,EGFR,NF1,PIK3R1,CDKN2A,GATA3,RB1,NOTCH1,FBXW7,CTNNB1,MAP3K1,FLT3,KEAP1,CTCF,NPM1,MAP2K4,STK11,CRIPAK,CEBPA,EPHA3,AKT1,AR,PIK3CG,CDKN1B,HGF,MTOR,TLR4,ARID5B,LRRK2,FOXA1,KIT,PDGFRA,EP300,FGFR2,CCND1,FOXA2,FGFR3,TGFBR2,CDKN1A,TAF1,PPP2R1A,SIN3A,EIF4A2,CDK12,MAPK8IP1,NSD1,RPL5,SMAD2,CDKN2C,EZH2
GO:0006950	response to stress	7.106565289878863e-14	7.106565289878863e-14	+1	TP53,PIK3CA,PTEN,APC,VHL,KRAS,EGFR,NF1,PIK3R1,CDKN2A,GATA3,RB1,NOTCH1,FBXW7,MAP3K1,ARHGAP35,NFE2L2,NPM1,NRAS,TBX3,MAP2K4,STK11,CRIPAK,CEBPA,AKT1,BRAF,AJUBA,EPPK1,PIK3CG,ATM,CDKN1B,HGF,ERBB4,MTOR,TLR4,ATRX,ELF3,BRCA1,LRRK2,POLQ,CHEK2,KIT,SETD2,PDGFRA,EP300,CCND1,SMAD4,FOXA2,BRCA2,CDKN1A,TAF1,ATR,SIN3A,VEZF1,SMC1A,PTPN11,MAPK8IP1,MECOM,NCOR1,AXIN2,MIR142,RAD21,ERCC2
GO:0032270	positive regulation of cellular protein metabolic process	7.769727147477665e-14	7.769727147477665e-14	+1	TP53,PTEN,KRAS,EGFR,CDKN2A,NOTCH1,FBXW7,CTNNB1,MAP3K1,FLT3,KEAP1,NFE2L2,NPM1,MAP2K4,STK11,CEBPA,AKT1,BRAF,PIK3CG,SOX9,HGF,ERBB4,MTOR,TLR4,BRCA1,LRRK2,KIT,PDGFRA,FGFR2,CCND1,SMAD4,FGFR3,TGFBR2,CDKN1A,TAF1,PTPN11,MAPK8IP1,ACVR2A,RPL5,AXIN2,EZH2
GO:0065007	biological regulation	8.164565937262828e-14	8.164565937262828e-14	+1	TP53,PIK3CA,PTEN,APC,VHL,KRAS,ARID1A,PBRM1,NAV3,EGFR,NF1,PIK3R1,CDKN2A,GATA3,RB1,NOTCH1,FBXW7,CTNNB1,DNMT3A,MAP3K1,FLT3,TSHZ3,KEAP1,CDH1,ARHGAP35,CTCF,NFE2L2,BAP1,NPM1,RUNX1,NRAS,IDH1,TBX3,MAP2K4,STK11,CRIPAK,CEBPA,EPHA3,AKT1,STAG2,BRAF,AR,AJUBA,EPPK1,TSHZ2,PIK3CG,SOX9,ATM,CDKN1B,WT1,HGF,KDM5C,PRX,ERBB4,MTOR,TLR4,ARID5B,TET2,ATRX,ELF3,BRCA1,LRRK2,POLQ,FOXA1,CHEK2,KIT,HIST1H1C,SETD2,PDGFRA,EP300,FGFR2,CCND1,SMAD4,FOXA2,USP9X,BRCA2,NFE2L3,FGFR3,ASXL1,TGFBR2,SOX17,CDKN1A,SF3B1,TAF1,PPP2R1A,CBFB,ATR,SIN3A,VEZF1,EIF4A2,CDK12,PHF6,SMC1A,PTPN11,ACVR1B,MAPK8IP1,H3F3C,NSD1,TBL1XR1,EGR3,ACVR2A,MECOM,LIFR,SMC3,NCOR1,RPL5,SMAD2,SPOP,AXIN2,MIR142,RAD21,ERCC2,CDKN2C,EZH2
GO:0048731	system development	8.164565937262828e-14	8.164565937262828e-14	+1	PIK3CA,PTEN,NAV3,EGFR,NF1,PIK3R1,CDKN2A,GATA3,RB1,NOTCH1,FBXW7,CTNNB1,FLT3,CDH1,ARHGAP35,RUNX1,TBX3,STK11,CEBPA,EPHA3,AKT1,BRAF,AR,SOX9,ATM,CDKN1B,WT1,HGF,PRX,ERBB4,MTOR,TLR4,ARID5B,TET2,ELF3,BRCA1,LRRK2,POLQ,FOXA1,KIT,PDGFRA,EP300,FGFR2,SMAD4,FOXA2,USP9X,BRCA2,FGFR3,ASXL1,TGFBR2,SOX17,CDKN1A,TAF1,CBFB,SIN3A,PTPN11,ACVR1B,EGR3,ACVR2A,MECOM,SMAD2,AXIN2,MIR142,ERCC2,EZH2
GO:0045859	regulation of protein kinase activity	9.503371201274638e-14	9.503371201274638e-14	+1	PTEN,APC,EGFR,NF1,CDKN2A,RB1,FBXW7,MAP3K1,FLT3,NPM1,MAP2K4,STK11,CRIPAK,CEBPA,AKT1,PIK3CG,CDKN1B,MTOR,TLR4,LRRK2,KIT,CCND1,TGFBR2,CDKN1A,PPP2R1A,CDK12,MAPK8IP1,CDKN2C,EZH2
GO:0032502	developmental process	1.0563113300387024e-13	1.0563113300387024e-13	+1	TP53,PIK3CA,PTEN,APC,VHL,NAV3,EGFR,NF1,PIK3R1,CDKN2A,GATA3,RB1,NOTCH1,FBXW7,CTNNB1,FLT3,CDH1,ARHGAP35,NPM1,RUNX1,TBX3,STK11,CEBPA,EPHA3,AKT1,BRAF,AR,EPPK1,SOX9,ATM,CDKN1B,WT1,HGF,PRX,ERBB4,MTOR,TLR4,ARID5B,TET2,ELF3,BRCA1,LRRK2,POLQ,FOXA1,CHEK2,KIT,SETD2,PDGFRA,EP300,FGFR2,SMAD4,FOXA2,USP9X,BRCA2,FGFR3,ASXL1,TGFBR2,SOX17,CDKN1A,TAF1,PPP2R1A,CBFB,ATR,SIN3A,VEZF1,PTPN11,ACVR1B,EGR3,ACVR2A,MECOM,SMAD2,AXIN2,MIR142,ERCC2,EZH2
GO:0016043	cellular component organization	1.2036249533781595e-13	1.2036249533781595e-13	+1	TP53,PIK3CA,PTEN,APC,VHL,ARID1A,PBRM1,NAV3,EGFR,NF1,PIK3R1,CDKN2A,RB1,NOTCH1,FBXW7,CTNNB1,CDH1,ARHGAP35,CTCF,BAP1,NPM1,RUNX1,IDH1,STK11,CRIPAK,KDM6A,EPHA3,AKT1,STAG2,AR,AJUBA,EPPK1,SOX9,ATM,CDKN1B,WT1,HGF,KDM5C,ERBB4,MTOR,TLR4,TET2,ATRX,BRCA1,LRRK2,POLQ,FOXA1,CHEK2,KIT,HIST1H1C,SETD2,PDGFRA,EP300,FGFR2,CCND1,SMAD4,USP9X,BRCA2,ASXL1,SOX17,CDKN1A,SF3B1,TAF1,PPP2R1A,CBFB,ATR,SIN3A,HIST1H2BD,SMC1A,PTPN11,ACVR1B,H3F3C,NSD1,TBL1XR1,SMC3,NCOR1,RPL5,SMAD2,AXIN2,RAD21,ERCC2,CDKN2C,EZH2
GO:0045786	negative regulation of cell cycle	1.4411523507489855e-13	1.4411523507489855e-13	+1	TP53,PTEN,APC,CDKN2A,GATA3,RB1,NOTCH1,FBXW7,CTNNB1,NPM1,STK11,CEBPA,STAG2,ATM,CDKN1B,MTOR,ATRX,BRCA1,CHEK2,EP300,CCND1,CDKN1A,ATR,SMC1A,SMC3,CDKN2C,EZH2
GO:0048856	anatomical structure development	1.758259286753428e-13	1.758259286753428e-13	+1	TP53,PIK3CA,PTEN,APC,VHL,NAV3,EGFR,NF1,PIK3R1,CDKN2A,GATA3,RB1,NOTCH1,FBXW7,CTNNB1,FLT3,CDH1,ARHGAP35,RUNX1,TBX3,STK11,CEBPA,EPHA3,AKT1,BRAF,AR,EPPK1,SOX9,ATM,CDKN1B,WT1,HGF,PRX,ERBB4,MTOR,TLR4,ARID5B,TET2,ELF3,BRCA1,LRRK2,POLQ,FOXA1,KIT,SETD2,PDGFRA,EP300,FGFR2,SMAD4,FOXA2,USP9X,BRCA2,FGFR3,ASXL1,TGFBR2,SOX17,CDKN1A,TAF1,CBFB,ATR,SIN3A,VEZF1,PTPN11,ACVR1B,EGR3,ACVR2A,MECOM,SMAD2,AXIN2,MIR142,ERCC2,EZH2
GO:0080134	regulation of response to stress	2.1778019805909786e-13	2.1778019805909786e-13	+1	PTEN,KRAS,EGFR,PIK3R1,CDKN2A,GATA3,RB1,FBXW7,MAP3K1,NFE2L2,NPM1,NRAS,MAP2K4,CEBPA,AKT1,AJUBA,EPPK1,ATM,CDKN1B,HGF,MTOR,TLR4,BRCA1,LRRK2,POLQ,SETD2,PDGFRA,EP300,FOXA2,CDKN1A,ATR,SIN3A,PTPN11,MAPK8IP1,MECOM,NCOR1,AXIN2,MIR142
GO:0071310	cellular response to organic substance	3.6162490525207433e-13	3.6162490525207433e-13	+1	TP53,PIK3CA,APC,ARID1A,EGFR,PIK3R1,GATA3,RB1,NOTCH1,CTNNB1,FLT3,CDH1,NFE2L2,NPM1,RUNX1,STK11,CRIPAK,CEBPA,EPHA3,AKT1,AR,SOX9,ATM,WT1,HGF,MTOR,TLR4,BRCA1,LRRK2,FOXA1,KIT,PDGFRA,EP300,FGFR2,CCND1,SMAD4,FOXA2,USP9X,FGFR3,TGFBR2,CDKN1A,TAF1,CBFB,PTPN11,ACVR1B,EGR3,ACVR2A,LIFR,NCOR1,SMAD2
GO:0006325	chromatin organization	4.028299662229212e-13	4.028299662229212e-13	+1	TP53,ARID1A,PBRM1,CDKN2A,RB1,CTNNB1,CTCF,BAP1,NPM1,KDM6A,SOX9,KDM5C,TET2,ATRX,BRCA1,FOXA1,HIST1H1C,SETD2,EP300,SMAD4,BRCA2,ASXL1,SIN3A,HIST1H2BD,H3F3C,NSD1,TBL1XR1,EZH2
GO:0008285	negative regulation of cell population proliferation	4.235835604422853e-13	4.235835604422853e-13	+1	TP53,PTEN,APC,VHL,PBRM1,NF1,CDKN2A,GATA3,NOTCH1,FBXW7,CTNNB1,CTCF,BAP1,NPM1,STK11,CEBPA,AR,EPPK1,SOX9,ATM,CDKN1B,WT1,ERBB4,BRCA2,CDKN1A,AXIN2,CDKN2C
GO:0048732	gland development	4.924668656131466e-13	4.924668656131466e-13	+1	NF1,GATA3,FBXW7,ARHGAP35,TBX3,CEBPA,AKT1,AR,SOX9,WT1,HGF,ERBB4,ARID5B,ELF3,FGFR2,BRCA2
GO:0031401	positive regulation of protein modification process	6.642778572249918e-13	6.642778572249918e-13	+1	TP53,PTEN,KRAS,EGFR,CDKN2A,NOTCH1,FBXW7,CTNNB1,MAP3K1,FLT3,MAP2K4,STK11,AKT1,BRAF,PIK3CG,SOX9,HGF,ERBB4,MTOR,TLR4,BRCA1,LRRK2,KIT,PDGFRA,FGFR2,CCND1,SMAD4,FGFR3,TGFBR2,CDKN1A,PTPN11,MAPK8IP1,ACVR2A,AXIN2,EZH2
GO:0012501	programmed cell death	7.170784063113484e-13	7.170784063113484e-13	+1	TP53,PIK3CA,PTEN,APC,VHL,EGFR,NF1,PIK3R1,CDKN2A,GATA3,NOTCH1,FBXW7,CTNNB1,FLT3,NFE2L2,NPM1,TBX3,STK11,AKT1,BRAF,AR,SOX9,ATM,CDKN1B,WT1,HGF,ERBB4,MTOR,TLR4,BRCA1,LRRK2,FOXA1,CHEK2,EP300,FGFR2,FGFR3,TGFBR2,CDKN1A,PPP2R1A,ACVR1B,EGR3,MECOM,ERCC2
GO:0071840	cellular component organization or biogenesis	7.487644407425286e-13	7.487644407425286e-13	+1	TP53,PIK3CA,PTEN,APC,VHL,ARID1A,PBRM1,NAV3,EGFR,NF1,PIK3R1,CDKN2A,RB1,NOTCH1,FBXW7,CTNNB1,CDH1,ARHGAP35,CTCF,BAP1,NPM1,RUNX1,IDH1,STK11,CRIPAK,KDM6A,EPHA3,AKT1,STAG2,AR,AJUBA,EPPK1,SOX9,ATM,CDKN1B,WT1,HGF,KDM5C,ERBB4,MTOR,TLR4,TET2,ATRX,BRCA1,LRRK2,POLQ,FOXA1,CHEK2,KIT,HIST1H1C,SETD2,PDGFRA,EP300,FGFR2,CCND1,SMAD4,USP9X,BRCA2,ASXL1,SOX17,CDKN1A,SF3B1,TAF1,PPP2R1A,CBFB,ATR,SIN3A,HIST1H2BD,SMC1A,PTPN11,ACVR1B,H3F3C,NSD1,TBL1XR1,SMC3,NCOR1,RPL5,SMAD2,AXIN2,RAD21,ERCC2,CDKN2C,EZH2
GO:0006915	apoptotic process	7.743215033477726e-13	7.743215033477726e-13	+1	TP53,PIK3CA,PTEN,APC,VHL,EGFR,NF1,PIK3R1,CDKN2A,GATA3,NOTCH1,FBXW7,CTNNB1,FLT3,NFE2L2,NPM1,TBX3,STK11,AKT1,BRAF,AR,SOX9,ATM,WT1,HGF,ERBB4,MTOR,TLR4,BRCA1,LRRK2,FOXA1,CHEK2,EP300,FGFR2,FGFR3,TGFBR2,CDKN1A,PPP2R1A,ACVR1B,EGR3,ERCC2
GO:0009967	positive regulation of signal transduction	9.13116533023333e-13	9.13116533023333e-13	+1	TP53,PIK3CA,PTEN,EGFR,PIK3R1,GATA3,NOTCH1,FBXW7,FLT3,MAP2K4,STK11,AKT1,BRAF,PIK3CG,SOX9,ATM,HGF,ERBB4,TLR4,ELF3,LRRK2,FOXA1,KIT,PDGFRA,EP300,FGFR2,SMAD4,FGFR3,ASXL1,TAF1,ATR,PTPN11,ACVR1B,MAPK8IP1,TBL1XR1,ACVR2A,SMAD2,AXIN2,EZH2
GO:0008219	cell death	1.5442426837754737e-12	1.5442426837754737e-12	+1	TP53,PIK3CA,PTEN,APC,VHL,EGFR,NF1,PIK3R1,CDKN2A,GATA3,NOTCH1,FBXW7,CTNNB1,FLT3,NFE2L2,NPM1,TBX3,STK11,AKT1,BRAF,AR,SOX9,ATM,CDKN1B,WT1,HGF,ERBB4,MTOR,TLR4,BRCA1,LRRK2,FOXA1,CHEK2,EP300,FGFR2,FGFR3,TGFBR2,CDKN1A,PPP2R1A,ACVR1B,EGR3,MECOM,AXIN2,ERCC2
GO:0035556	intracellular signal transduction	1.6546679483168548e-12	1.6546679483168548e-12	+1	TP53,PIK3CA,PTEN,KRAS,EGFR,NF1,PIK3R1,CDKN2A,GATA3,RB1,NOTCH1,FBXW7,MAP3K1,FLT3,ARHGAP35,NFE2L2,NRAS,MAP2K4,STK11,AKT1,BRAF,AJUBA,PIK3CG,SOX9,ATM,CDKN1B,HGF,ERBB4,MTOR,TLR4,ATRX,BRCA1,LRRK2,CHEK2,KIT,PDGFRA,EP300,FGFR2,SMAD4,FGFR3,CDKN1A,TAF1,PPP2R1A,ATR,CDK12,PTPN11,MAPK8IP1,MECOM,NCOR1,RPL5,SMAD2,EZH2
GO:0030154	cell differentiation	1.7188572896849976e-12	1.7188572896849976e-12	+1	TP53,PIK3CA,PTEN,APC,VHL,EGFR,NF1,PIK3R1,CDKN2A,GATA3,RB1,NOTCH1,FBXW7,CTNNB1,FLT3,ARHGAP35,RUNX1,TBX3,CEBPA,EPHA3,AKT1,AR,SOX9,ATM,WT1,HGF,ERBB4,MTOR,TLR4,TET2,ELF3,LRRK2,FOXA1,KIT,SETD2,PDGFRA,EP300,FGFR2,SMAD4,FOXA2,USP9X,FGFR3,ASXL1,TGFBR2,SOX17,PPP2R1A,CBFB,SIN3A,VEZF1,PTPN11,ACVR1B,ACVR2A,SMAD2,AXIN2,MIR142,ERCC2,EZH2
GO:0010647	positive regulation of cell communication	1.8106342413929294e-12	1.8106342413929294e-12	+1	TP53,PIK3CA,PTEN,EGFR,PIK3R1,GATA3,NOTCH1,FBXW7,FLT3,TSHZ3,MAP2K4,STK11,AKT1,BRAF,PIK3CG,SOX9,ATM,HGF,ERBB4,TLR4,ELF3,LRRK2,FOXA1,KIT,PDGFRA,EP300,FGFR2,SMAD4,FGFR3,ASXL1,TAF1,ATR,PTPN11,ACVR1B,MAPK8IP1,TBL1XR1,ACVR2A,SMAD2,AXIN2,EZH2
GO:0042221	response to chemical	2.0120363353993145e-12	2.0120363353993145e-12	+1	TP53,PIK3CA,APC,VHL,ARID1A,EGFR,PIK3R1,GATA3,RB1,NOTCH1,FBXW7,CTNNB1,FLT3,CDH1,ARHGAP35,NFE2L2,NPM1,RUNX1,IDH1,STK11,CRIPAK,CEBPA,EPHA3,AKT1,BRAF,AR,AJUBA,PIK3CG,SOX9,ATM,CDKN1B,WT1,HGF,MTOR,TLR4,ATRX,BRCA1,LRRK2,FOXA1,KIT,SETD2,PDGFRA,EP300,FGFR2,CCND1,SMAD4,FOXA2,USP9X,FGFR3,ASXL1,TGFBR2,CDKN1A,TAF1,PPP2R1A,CBFB,PTPN11,ACVR1B,EGR3,ACVR2A,LIFR,NCOR1,SMAD2
GO:0023056	positive regulation of signaling	2.108344715070624e-12	2.108344715070624e-12	+1	TP53,PIK3CA,PTEN,EGFR,PIK3R1,GATA3,NOTCH1,FBXW7,FLT3,TSHZ3,MAP2K4,STK11,AKT1,BRAF,PIK3CG,SOX9,ATM,HGF,ERBB4,TLR4,ELF3,LRRK2,FOXA1,KIT,PDGFRA,EP300,FGFR2,SMAD4,FGFR3,ASXL1,TAF1,ATR,PTPN11,ACVR1B,MAPK8IP1,TBL1XR1,ACVR2A,SMAD2,AXIN2,EZH2
GO:0042327	positive regulation of phosphorylation	2.352265581818824e-12	2.352265581818824e-12	+1	TP53,KRAS,EGFR,NOTCH1,FBXW7,MAP3K1,FLT3,MAP2K4,STK11,AKT1,BRAF,AR,PIK3CG,SOX9,HGF,ERBB4,MTOR,TLR4,LRRK2,KIT,PDGFRA,FGFR2,CCND1,SMAD4,FGFR3,TGFBR2,CDKN1A,PTPN11,MAPK8IP1,ACVR2A,AXIN2,EZH2
GO:0048585	negative regulation of response to stimulus	2.405394447181886e-12	2.405394447181886e-12	+1	PTEN,APC,VHL,EGFR,NF1,GATA3,RB1,NOTCH1,FBXW7,NFE2L2,STK11,CRIPAK,AKT1,AR,AJUBA,EPPK1,SOX9,ATM,CDKN1B,HGF,TLR4,BRCA1,LRRK2,POLQ,PDGFRA,SMAD4,FOXA2,ASXL1,TGFBR2,SOX17,CDKN1A,PPP2R1A,MAPK8IP1,MECOM,NCOR1,SMAD2,AXIN2,EZH2
GO:0010564	regulation of cell cycle process	3.217560161399693e-12	3.217560161399693e-12	+1	TP53,PTEN,APC,CDKN2A,RB1,FBXW7,CTNNB1,CTCF,NPM1,STAG2,SOX9,ATM,CDKN1B,ATRX,BRCA1,CHEK2,SETD2,EP300,CCND1,CDKN1A,TAF1,PPP2R1A,SMC1A,SMC3,AXIN2,RAD21,ERCC2,EZH2
GO:0001934	positive regulation of protein phosphorylation	3.90340327013731e-12	3.90340327013731e-12	+1	TP53,KRAS,EGFR,NOTCH1,FBXW7,MAP3K1,FLT3,MAP2K4,STK11,AKT1,BRAF,PIK3CG,SOX9,HGF,ERBB4,MTOR,TLR4,LRRK2,KIT,PDGFRA,FGFR2,CCND1,SMAD4,FGFR3,TGFBR2,CDKN1A,PTPN11,MAPK8IP1,ACVR2A,AXIN2,EZH2
GO:0009628	response to abiotic stimulus	3.9252781065127356e-12	3.9252781065127356e-12	+1	TP53,PTEN,VHL,EGFR,NF1,GATA3,NOTCH1,MAP3K1,NFE2L2,NPM1,MAP2K4,STK11,CRIPAK,AKT1,AJUBA,SOX9,ATM,MTOR,TLR4,BRCA1,KIT,EP300,CCND1,SMAD4,CDKN1A,TAF1,ATR,SMC1A,ERCC2
GO:0033554	cellular response to stress	4.058659920882344e-12	4.058659920882344e-12	+1	TP53,APC,VHL,EGFR,PIK3R1,CDKN2A,NOTCH1,FBXW7,MAP3K1,NFE2L2,NPM1,TBX3,MAP2K4,STK11,CRIPAK,AKT1,BRAF,AJUBA,ATM,CDKN1B,HGF,MTOR,TLR4,ATRX,BRCA1,LRRK2,POLQ,CHEK2,SETD2,PDGFRA,EP300,CCND1,BRCA2,CDKN1A,TAF1,ATR,SMC1A,MAPK8IP1,MECOM,NCOR1,AXIN2,RAD21,ERCC2
GO:0040007	growth	4.975188243620345e-12	4.975188243620345e-12	+1	TP53,PTEN,EGFR,CDKN2A,NOTCH1,CTNNB1,BAP1,STK11,AKT1,EPPK1,SOX9,CDKN1B,WT1,ERBB4,MTOR,FGFR2,SMAD4,USP9X,FGFR3,SOX17,CDKN1A,PPP2R1A,ACVR1B,H3F3C,CDKN2C
GO:1902531	regulation of intracellular signal transduction	5.5178237489861655e-12	5.5178237489861655e-12	+1	TP53,PIK3CA,PTEN,EGFR,NF1,PIK3R1,GATA3,NOTCH1,FBXW7,FLT3,ARHGAP35,NFE2L2,MAP2K4,STK11,AKT1,BRAF,AJUBA,PIK3CG,SOX9,ATM,HGF,ERBB4,TLR4,LRRK2,CHEK2,KIT,PDGFRA,EP300,FGFR2,SMAD4,FGFR3,TAF1,PPP2R1A,ATR,CDK12,PTPN11,MAPK8IP1,MECOM,NCOR1,RPL5,EZH2
GO:0046777	protein autophosphorylation	7.762528676134403e-12	7.762528676134403e-12	+1	EGFR,FLT3,STK11,AKT1,ATM,ERBB4,MTOR,LRRK2,CHEK2,KIT,PDGFRA,FGFR2,FGFR3,TAF1,ATR,CDK12,ACVR1B
GO:0048762	mesenchymal cell differentiation	8.660720656013718e-12	8.660720656013718e-12	+1	PTEN,NOTCH1,CTNNB1,EPHA3,SOX9,HGF,ERBB4,MTOR,FOXA1,FGFR2,SMAD4,FOXA2,TGFBR2,SMAD2,AXIN2,EZH2
GO:0060485	mesenchyme development	9.001228285508567e-12	9.001228285508567e-12	+1	PTEN,NOTCH1,CTNNB1,EPHA3,SOX9,WT1,HGF,ERBB4,MTOR,FOXA1,FGFR2,SMAD4,FOXA2,TGFBR2,SMAD2,AXIN2,EZH2
GO:0045937	positive regulation of phosphate metabolic process	9.037945844731698e-12	9.037945844731698e-12	+1	TP53,KRAS,EGFR,NOTCH1,FBXW7,MAP3K1,FLT3,MAP2K4,STK11,AKT1,BRAF,AR,PIK3CG,SOX9,HGF,ERBB4,MTOR,TLR4,LRRK2,KIT,PDGFRA,FGFR2,CCND1,SMAD4,FGFR3,TGFBR2,CDKN1A,PTPN11,MAPK8IP1,ACVR2A,AXIN2,EZH2
GO:0010562	positive regulation of phosphorus metabolic process	9.037945844731698e-12	9.037945844731698e-12	+1	TP53,KRAS,EGFR,NOTCH1,FBXW7,MAP3K1,FLT3,MAP2K4,STK11,AKT1,BRAF,AR,PIK3CG,SOX9,HGF,ERBB4,MTOR,TLR4,LRRK2,KIT,PDGFRA,FGFR2,CCND1,SMAD4,FGFR3,TGFBR2,CDKN1A,PTPN11,MAPK8IP1,ACVR2A,AXIN2,EZH2
GO:0022402	cell cycle process	9.708006630069803e-12	9.708006630069803e-12	+1	TP53,PTEN,APC,CDKN2A,RB1,NOTCH1,FBXW7,CTNNB1,CTCF,NPM1,STK11,STAG2,AJUBA,SOX9,ATM,CDKN1B,MTOR,ATRX,BRCA1,CHEK2,SETD2,EP300,CCND1,BRCA2,CDKN1A,TAF1,PPP2R1A,SMC1A,ACVR1B,SMC3,NCOR1,AXIN2,RAD21,ERCC2,CDKN2C,EZH2
GO:0001837	epithelial to mesenchymal transition	9.823095543418206e-12	9.823095543418206e-12	+1	PTEN,NOTCH1,CTNNB1,EPHA3,SOX9,HGF,MTOR,FOXA1,SMAD4,FOXA2,TGFBR2,SMAD2,AXIN2,EZH2
GO:0006996	organelle organization	1.3776758396478522e-11	1.3776758396478522e-11	+1	TP53,PTEN,APC,ARID1A,PBRM1,NAV3,NF1,CDKN2A,RB1,NOTCH1,FBXW7,CTNNB1,ARHGAP35,CTCF,BAP1,NPM1,IDH1,CRIPAK,KDM6A,EPHA3,AKT1,STAG2,AJUBA,EPPK1,SOX9,ATM,HGF,KDM5C,ERBB4,MTOR,TET2,ATRX,BRCA1,LRRK2,FOXA1,CHEK2,KIT,HIST1H1C,SETD2,PDGFRA,EP300,CCND1,SMAD4,USP9X,BRCA2,ASXL1,PPP2R1A,ATR,SIN3A,HIST1H2BD,SMC1A,H3F3C,NSD1,TBL1XR1,SMC3,NCOR1,RPL5,AXIN2,RAD21,ERCC2,EZH2
GO:0031400	negative regulation of protein modification process	1.4802581739431794e-11	1.4802581739431794e-11	+1	PTEN,APC,NF1,CDKN2A,RB1,CTNNB1,NPM1,CRIPAK,CEBPA,AKT1,CDKN1B,TLR4,BRCA1,LRRK2,SMAD4,CDKN1A,TAF1,PPP2R1A,SIN3A,MAPK8IP1,MECOM,NCOR1,RPL5
GO:0040008	regulation of growth	1.743518919007315e-11	1.743518919007315e-11	+1	TP53,PTEN,EGFR,CDKN2A,NOTCH1,BAP1,STK11,AKT1,EPPK1,CDKN1B,WT1,ERBB4,MTOR,FGFR2,SMAD4,FGFR3,SOX17,CDKN1A,PPP2R1A,ACVR1B,H3F3C,CDKN2C
GO:0010717	regulation of epithelial to mesenchymal transition	2.561284259315476e-11	2.561284259315476e-11	+1	PTEN,NOTCH1,CTNNB1,EPHA3,MTOR,FOXA1,SMAD4,FOXA2,TGFBR2,SMAD2,AXIN2,EZH2
GO:0051716	cellular response to stimulus	2.8480069246093983e-11	2.8480069246093983e-11	+1	TP53,PIK3CA,PTEN,APC,VHL,KRAS,ARID1A,EGFR,NF1,PIK3R1,CDKN2A,GATA3,RB1,NOTCH1,FBXW7,CTNNB1,MAP3K1,FLT3,CDH1,ARHGAP35,NFE2L2,NPM1,RUNX1,NRAS,TBX3,MAP2K4,STK11,CRIPAK,CEBPA,EPHA3,AKT1,BRAF,AR,AJUBA,PIK3CG,SOX9,ATM,CDKN1B,WT1,HGF,ERBB4,MTOR,TLR4,ATRX,ELF3,BRCA1,LRRK2,POLQ,FOXA1,CHEK2,KIT,SETD2,PDGFRA,EP300,FGFR2,CCND1,SMAD4,FOXA2,USP9X,BRCA2,FGFR3,ASXL1,TGFBR2,SOX17,CDKN1A,TAF1,PPP2R1A,CBFB,ATR,CDK12,SMC1A,PTPN11,ACVR1B,MAPK8IP1,TBL1XR1,EGR3,ACVR2A,MECOM,LIFR,NCOR1,RPL5,SMAD2,AXIN2,RAD21,ERCC2,EZH2
GO:0023014	signal transduction by protein phosphorylation	3.593067264799312e-11	3.593067264799312e-11	+1	PTEN,KRAS,EGFR,NF1,NOTCH1,FBXW7,MAP3K1,FLT3,NRAS,MAP2K4,BRAF,PIK3CG,SOX9,HGF,ERBB4,TLR4,LRRK2,KIT,PDGFRA,FGFR2,SMAD4,FGFR3,PPP2R1A,CDK12,PTPN11,MAPK8IP1,MECOM,NCOR1,EZH2
GO:0009888	tissue development	3.938813861611837e-11	3.938813861611837e-11	+1	PTEN,NF1,GATA3,NOTCH1,CTNNB1,ARHGAP35,RUNX1,TBX3,EPHA3,AKT1,EPPK1,SOX9,CDKN1B,WT1,HGF,ERBB4,MTOR,ARID5B,ELF3,FOXA1,SETD2,PDGFRA,FGFR2,SMAD4,FOXA2,BRCA2,FGFR3,TGFBR2,SOX17,CDKN1A,CBFB,VEZF1,ACVR2A,SMAD2,AXIN2,ERCC2,EZH2
GO:1901564	organonitrogen compound metabolic process	4.364807726949108e-11	4.364807726949108e-11	+1	TP53,PIK3CA,PTEN,APC,VHL,KRAS,EGFR,NF1,CDKN2A,GATA3,RB1,NOTCH1,FBXW7,CTNNB1,MAP3K1,FLT3,KEAP1,NFE2L2,BAP1,NPM1,NRAS,MAP2K4,STK11,CRIPAK,CEBPA,KDM6A,EPHA3,AKT1,BRAF,AR,PIK3CG,SOX9,ATM,CDKN1B,HGF,KDM5C,ERBB4,MTOR,TLR4,TET2,ATRX,BRCA1,LRRK2,CHEK2,KIT,HIST1H1C,SETD2,PDGFRA,EP300,FGFR2,CCND1,SMAD4,USP9X,BRCA2,FGFR3,ASXL1,TGFBR2,CDKN1A,B4GALT3,TAF1,PPP2R1A,CBFB,ATR,SIN3A,HIST1H2BD,EIF4A2,CDK12,PTPN11,ACVR1B,MAPK8IP1,NSD1,TBL1XR1,ACVR2A,MECOM,NCOR1,RPL5,SMAD2,SPOP,AXIN2,CDKN2C,EZH2
GO:0042326	negative regulation of phosphorylation	6.368571140995715e-11	6.368571140995715e-11	+1	PTEN,APC,NF1,CDKN2A,RB1,NPM1,CRIPAK,CEBPA,AKT1,CDKN1B,TLR4,LRRK2,SMAD4,FOXA2,CDKN1A,PPP2R1A,MAPK8IP1,MECOM,NCOR1,CDKN2C
GO:0071900	regulation of protein serine/threonine kinase activity	7.09009954112155e-11	7.09009954112155e-11	+1	PTEN,APC,EGFR,NF1,CDKN2A,FLT3,MAP2K4,CEBPA,AKT1,PIK3CG,CDKN1B,TLR4,LRRK2,KIT,CCND1,CDKN1A,PPP2R1A,CDK12,MAPK8IP1,CDKN2C,EZH2
GO:0007062	sister chromatid cohesion	8.078227438516305e-11	8.078227438516305e-11	+1	RB1,FBXW7,CTNNB1,CTCF,STAG2,ATRX,SMC1A,SMC3,AXIN2,RAD21
GO:0050790	regulation of catalytic activity	1.067366945966119e-10	1.067366945966119e-10	+1	TP53,PTEN,APC,EGFR,NF1,PIK3R1,CDKN2A,RB1,NOTCH1,FBXW7,MAP3K1,FLT3,NPM1,MAP2K4,STK11,CRIPAK,CEBPA,EPHA3,AKT1,PIK3CG,CDKN1B,HGF,MTOR,TLR4,LRRK2,KIT,PDGFRA,FGFR2,CCND1,FOXA2,FGFR3,TGFBR2,CDKN1A,PPP2R1A,EIF4A2,CDK12,MAPK8IP1,RPL5,CDKN2C,EZH2
GO:0000165	MAPK cascade	1.3713283002222985e-10	1.3713283002222985e-10	+1	PTEN,KRAS,EGFR,NF1,NOTCH1,FBXW7,FLT3,NRAS,MAP2K4,BRAF,PIK3CG,SOX9,HGF,ERBB4,TLR4,LRRK2,KIT,PDGFRA,FGFR2,SMAD4,FGFR3,PPP2R1A,CDK12,PTPN11,MAPK8IP1,MECOM,NCOR1,EZH2
GO:0010948	negative regulation of cell cycle process	1.8100609181976303e-10	1.8100609181976303e-10	+1	TP53,PTEN,APC,RB1,FBXW7,NPM1,STAG2,ATM,CDKN1B,ATRX,BRCA1,CHEK2,EP300,CCND1,CDKN1A,SMC1A,SMC3,EZH2
GO:0009968	negative regulation of signal transduction	2.0295302336502302e-10	2.0295302336502302e-10	+1	PTEN,APC,VHL,EGFR,NF1,GATA3,NOTCH1,FBXW7,NFE2L2,STK11,CRIPAK,AKT1,AR,AJUBA,SOX9,ATM,HGF,TLR4,BRCA1,LRRK2,SMAD4,ASXL1,TGFBR2,SOX17,PPP2R1A,MAPK8IP1,MECOM,NCOR1,SMAD2,AXIN2,EZH2
GO:0051348	negative regulation of transferase activity	2.511040452054039e-10	2.511040452054039e-10	+1	TP53,APC,NF1,CDKN2A,RB1,NPM1,CRIPAK,CEBPA,AKT1,CDKN1B,FOXA2,CDKN1A,PPP2R1A,EIF4A2,MAPK8IP1,RPL5
GO:0007165	signal transduction	3.082646149927914e-10	3.082646149927914e-10	+1	TP53,PIK3CA,PTEN,APC,VHL,KRAS,ARID1A,EGFR,NF1,PIK3R1,CDKN2A,GATA3,RB1,NOTCH1,FBXW7,CTNNB1,MAP3K1,FLT3,ARHGAP35,NFE2L2,NPM1,RUNX1,NRAS,MAP2K4,STK11,CRIPAK,CEBPA,EPHA3,AKT1,BRAF,AR,AJUBA,PIK3CG,SOX9,ATM,CDKN1B,HGF,ERBB4,MTOR,TLR4,ATRX,ELF3,BRCA1,LRRK2,FOXA1,CHEK2,KIT,PDGFRA,EP300,FGFR2,CCND1,SMAD4,USP9X,FGFR3,ASXL1,TGFBR2,SOX17,CDKN1A,TAF1,PPP2R1A,CBFB,ATR,CDK12,PTPN11,ACVR1B,MAPK8IP1,TBL1XR1,ACVR2A,MECOM,LIFR,NCOR1,RPL5,SMAD2,AXIN2,EZH2
GO:0016049	cell growth	3.1518613921016e-10	3.1518613921016e-10	+1	TP53,EGFR,CDKN2A,CTNNB1,BAP1,STK11,AKT1,SOX9,CDKN1B,WT1,MTOR,SMAD4,USP9X,SOX17,CDKN1A,PPP2R1A,ACVR1B,H3F3C,CDKN2C
GO:0023052	signaling	3.292103734628694e-10	3.292103734628694e-10	+1	TP53,PIK3CA,PTEN,APC,VHL,KRAS,ARID1A,EGFR,NF1,PIK3R1,CDKN2A,GATA3,RB1,NOTCH1,FBXW7,CTNNB1,MAP3K1,FLT3,TSHZ3,ARHGAP35,NFE2L2,NPM1,RUNX1,NRAS,TBX3,MAP2K4,STK11,CRIPAK,CEBPA,EPHA3,AKT1,BRAF,AR,AJUBA,PIK3CG,SOX9,ATM,CDKN1B,HGF,ERBB4,MTOR,TLR4,ATRX,ELF3,BRCA1,LRRK2,FOXA1,CHEK2,KIT,PDGFRA,EP300,FGFR2,CCND1,SMAD4,FOXA2,USP9X,FGFR3,ASXL1,TGFBR2,SOX17,CDKN1A,TAF1,PPP2R1A,CBFB,ATR,CDK12,PTPN11,ACVR1B,MAPK8IP1,TBL1XR1,ACVR2A,MECOM,LIFR,NCOR1,RPL5,SMAD2,AXIN2,EZH2
GO:2000026	regulation of multicellular organismal development	3.308068468802583e-10	3.308068468802583e-10	+1	PTEN,EGFR,NF1,CDKN2A,GATA3,NOTCH1,FBXW7,CTNNB1,ARHGAP35,RUNX1,EPHA3,AKT1,SOX9,WT1,HGF,ERBB4,MTOR,TLR4,BRCA1,LRRK2,FOXA1,KIT,EP300,FGFR2,SMAD4,FOXA2,BRCA2,TGFBR2,SOX17,CBFB,SIN3A,VEZF1,ACVR1B,ACVR2A,SMAD2,AXIN2,MIR142,EZH2
GO:0007154	cell communication	3.9718842388534343e-10	3.9718842388534343e-10	+1	TP53,PIK3CA,PTEN,APC,VHL,KRAS,ARID1A,EGFR,NF1,PIK3R1,CDKN2A,GATA3,RB1,NOTCH1,FBXW7,CTNNB1,MAP3K1,FLT3,TSHZ3,ARHGAP35,NFE2L2,NPM1,RUNX1,NRAS,TBX3,MAP2K4,STK11,CRIPAK,CEBPA,EPHA3,AKT1,BRAF,AR,AJUBA,PIK3CG,SOX9,ATM,CDKN1B,HGF,ERBB4,MTOR,TLR4,ATRX,ELF3,BRCA1,LRRK2,FOXA1,CHEK2,KIT,PDGFRA,EP300,FGFR2,CCND1,SMAD4,FOXA2,USP9X,FGFR3,ASXL1,TGFBR2,SOX17,CDKN1A,TAF1,PPP2R1A,CBFB,ATR,CDK12,PTPN11,ACVR1B,MAPK8IP1,TBL1XR1,ACVR2A,MECOM,LIFR,NCOR1,RPL5,SMAD2,AXIN2,EZH2
GO:0014065	phosphatidylinositol 3-kinase signaling	4.1855598287039705e-10	4.1855598287039705e-10	+1	PIK3CA,PTEN,EGFR,NF1,PIK3R1,GATA3,FLT3,AKT1,PIK3CG,SOX9,HGF,KIT,PDGFRA
GO:0010648	negative regulation of cell communication	7.288718287474658e-10	7.288718287474658e-10	+1	PTEN,APC,VHL,EGFR,NF1,GATA3,NOTCH1,FBXW7,NFE2L2,STK11,CRIPAK,AKT1,AR,AJUBA,SOX9,ATM,HGF,TLR4,BRCA1,LRRK2,SMAD4,ASXL1,TGFBR2,SOX17,PPP2R1A,MAPK8IP1,MECOM,NCOR1,SMAD2,AXIN2,EZH2
GO:0023057	negative regulation of signaling	8.195965113579278e-10	8.195965113579278e-10	+1	PTEN,APC,VHL,EGFR,NF1,GATA3,NOTCH1,FBXW7,NFE2L2,STK11,CRIPAK,AKT1,AR,AJUBA,SOX9,ATM,HGF,TLR4,BRCA1,LRRK2,SMAD4,ASXL1,TGFBR2,SOX17,PPP2R1A,MAPK8IP1,MECOM,NCOR1,SMAD2,AXIN2,EZH2
GO:0051239	regulation of multicellular organismal process	8.373085579349541e-10	8.373085579349541e-10	+1	PTEN,APC,NAV3,EGFR,NF1,CDKN2A,GATA3,RB1,NOTCH1,FBXW7,CTNNB1,TSHZ3,ARHGAP35,RUNX1,STK11,EPHA3,AKT1,EPPK1,PIK3CG,SOX9,WT1,HGF,ERBB4,MTOR,TLR4,BRCA1,LRRK2,FOXA1,KIT,SETD2,PDGFRA,EP300,FGFR2,SMAD4,FOXA2,BRCA2,TGFBR2,SOX17,CBFB,SIN3A,VEZF1,PTPN11,ACVR1B,ACVR2A,SMAD2,AXIN2,MIR142,EZH2
GO:0033043	regulation of organelle organization	8.514507858795045e-10	8.514507858795045e-10	+1	TP53,APC,NAV3,RB1,FBXW7,CTNNB1,ARHGAP35,CTCF,BAP1,NPM1,CRIPAK,EPHA3,AKT1,STAG2,ATM,HGF,MTOR,ATRX,BRCA1,LRRK2,HIST1H1C,PDGFRA,CCND1,SMAD4,ATR,SIN3A,SMC1A,NSD1,SMC3,AXIN2,RAD21
GO:0051094	positive regulation of developmental process	8.642582509752507e-10	8.642582509752507e-10	+1	VHL,CDKN2A,GATA3,NOTCH1,CTNNB1,ARHGAP35,RUNX1,EPHA3,AKT1,AR,SOX9,WT1,HGF,ERBB4,MTOR,BRCA1,KIT,EP300,FGFR2,SMAD4,FOXA2,TGFBR2,CBFB,VEZF1,ACVR1B,ACVR2A,SMAD2,AXIN2,MIR142,EZH2
GO:0001933	negative regulation of protein phosphorylation	1.0749356677767126e-9	1.0749356677767126e-9	+1	PTEN,APC,NF1,CDKN2A,RB1,NPM1,CRIPAK,CEBPA,AKT1,CDKN1B,TLR4,LRRK2,SMAD4,CDKN1A,PPP2R1A,MAPK8IP1,MECOM,NCOR1
GO:0043408	regulation of MAPK cascade	1.3734993834964263e-9	1.3734993834964263e-9	+1	PTEN,EGFR,NF1,NOTCH1,FBXW7,FLT3,MAP2K4,BRAF,PIK3CG,ERBB4,TLR4,LRRK2,KIT,PDGFRA,FGFR2,SMAD4,FGFR3,PPP2R1A,CDK12,PTPN11,MAPK8IP1,MECOM,NCOR1,EZH2
GO:0007507	heart development	1.675043925319435e-9	1.675043925319435e-9	+1	PTEN,EGFR,NF1,GATA3,RB1,NOTCH1,CTNNB1,SOX9,CDKN1B,WT1,ERBB4,PDGFRA,FGFR2,SMAD4,TGFBR2,SOX17,CDKN1A,PTPN11
GO:0051052	regulation of DNA metabolic process	1.7156914733953395e-9	1.7156914733953395e-9	+1	TP53,EGFR,CDKN2A,NPM1,AKT1,ATM,WT1,HGF,ATRX,BRCA1,POLQ,HIST1H1C,SETD2,USP9X,ATR,AXIN2,ERCC2
GO:0048015	phosphatidylinositol-mediated signaling	2.307756300245329e-9	2.307756300245329e-9	+1	PIK3CA,PTEN,EGFR,NF1,PIK3R1,GATA3,FLT3,AKT1,PIK3CG,SOX9,HGF,KIT,PDGFRA
GO:0009653	anatomical structure morphogenesis	2.3444246243063196e-9	2.3444246243063196e-9	+1	PIK3CA,PTEN,VHL,NF1,PIK3R1,GATA3,RB1,NOTCH1,FBXW7,CTNNB1,CDH1,ARHGAP35,RUNX1,TBX3,EPHA3,AKT1,BRAF,SOX9,WT1,HGF,ERBB4,MTOR,ELF3,BRCA1,LRRK2,FOXA1,KIT,SETD2,PDGFRA,FGFR2,SMAD4,FOXA2,USP9X,FGFR3,ASXL1,TGFBR2,SOX17,PTPN11,EGR3,SMAD2,AXIN2
GO:0048017	inositol lipid-mediated signaling	2.487911145328075e-9	2.487911145328075e-9	+1	PIK3CA,PTEN,EGFR,NF1,PIK3R1,GATA3,FLT3,AKT1,PIK3CG,SOX9,HGF,KIT,PDGFRA
GO:0007050	cell cycle arrest	2.6131947615574457e-9	2.6131947615574457e-9	+1	TP53,APC,CDKN2A,RB1,NOTCH1,STK11,ATM,CDKN1B,MTOR,BRCA1,CHEK2,EP300,CCND1,CDKN1A,CDKN2C
GO:0080135	regulation of cellular response to stress	2.7055049336393176e-9	2.7055049336393176e-9	+1	EGFR,PIK3R1,CDKN2A,FBXW7,NFE2L2,NPM1,MAP2K4,AKT1,AJUBA,ATM,HGF,MTOR,TLR4,BRCA1,LRRK2,POLQ,SETD2,EP300,ATR,MAPK8IP1,MECOM,NCOR1,AXIN2
GO:0014070	response to organic cyclic compound	2.7673652478878368e-9	2.7673652478878368e-9	+1	ARID1A,EGFR,RB1,CTNNB1,CDH1,NPM1,RUNX1,IDH1,CRIPAK,AR,WT1,BRCA1,LRRK2,FOXA1,EP300,TGFBR2,TAF1,CBFB,NCOR1,SMAD2
GO:0009411	response to UV	2.868780819755773e-9	2.868780819755773e-9	+1	TP53,EGFR,NPM1,STK11,CRIPAK,AKT1,EP300,CCND1,CDKN1A,TAF1,ATR,ERCC2
GO:0034968	histone lysine methylation	2.92700187223569e-9	2.92700187223569e-9	+1	CTNNB1,KDM6A,TET2,ATRX,BRCA1,HIST1H1C,SETD2,SMAD4,NSD1,EZH2
GO:0045936	negative regulation of phosphate metabolic process	2.9567063938273817e-9	2.9567063938273817e-9	+1	PTEN,APC,NF1,CDKN2A,RB1,NPM1,CRIPAK,CEBPA,AKT1,CDKN1B,TLR4,LRRK2,SMAD4,FOXA2,CDKN1A,PPP2R1A,MAPK8IP1,MECOM,NCOR1,CDKN2C
GO:0010563	negative regulation of phosphorus metabolic process	3.0536314374005044e-9	3.0536314374005044e-9	+1	PTEN,APC,NF1,CDKN2A,RB1,NPM1,CRIPAK,CEBPA,AKT1,CDKN1B,TLR4,LRRK2,SMAD4,FOXA2,CDKN1A,PPP2R1A,MAPK8IP1,MECOM,NCOR1,CDKN2C
GO:0045926	negative regulation of growth	3.0536314374005044e-9	3.0536314374005044e-9	+1	TP53,PTEN,CDKN2A,NOTCH1,STK11,CDKN1B,WT1,SMAD4,FGFR3,SOX17,CDKN1A,PPP2R1A,ACVR1B,CDKN2C
GO:0009887	animal organ morphogenesis	3.6160132097543305e-9	3.6160132097543305e-9	+1	PTEN,NF1,GATA3,NOTCH1,FBXW7,CTNNB1,TBX3,BRAF,SOX9,WT1,HGF,ELF3,LRRK2,PDGFRA,FGFR2,SMAD4,FGFR3,ASXL1,TGFBR2,SOX17,SMAD2,AXIN2
GO:0072359	circulatory system development	4.210983809698724e-9	4.210983809698724e-9	+1	PIK3CA,PTEN,EGFR,NF1,GATA3,RB1,NOTCH1,FBXW7,CTNNB1,RUNX1,STK11,AKT1,SOX9,CDKN1B,WT1,ERBB4,BRCA1,KIT,PDGFRA,FGFR2,SMAD4,TGFBR2,SOX17,CDKN1A,PTPN11,EGR3
GO:0009314	response to radiation	4.326398681150726e-9	4.326398681150726e-9	+1	TP53,EGFR,NF1,GATA3,NPM1,STK11,CRIPAK,AKT1,ATM,BRCA1,EP300,CCND1,CDKN1A,TAF1,ATR,SMC1A,ERCC2
GO:0044770	cell cycle phase transition	5.305983515653929e-9	5.305983515653929e-9	+1	TP53,PTEN,APC,CDKN2A,RB1,FBXW7,NPM1,AJUBA,ATM,CDKN1B,BRCA1,CHEK2,EP300,CCND1,CDKN1A,TAF1,PPP2R1A,ACVR1B,ERCC2,CDKN2C,EZH2
GO:0050896	response to stimulus	5.368020943107065e-9	5.368020943107065e-9	+1	TP53,PIK3CA,PTEN,APC,VHL,KRAS,ARID1A,EGFR,NF1,PIK3R1,CDKN2A,GATA3,RB1,NOTCH1,FBXW7,CTNNB1,MAP3K1,FLT3,CDH1,ARHGAP35,NFE2L2,NPM1,RUNX1,NRAS,IDH1,TBX3,MAP2K4,STK11,CRIPAK,CEBPA,EPHA3,AKT1,BRAF,AR,AJUBA,EPPK1,PIK3CG,SOX9,ATM,CDKN1B,WT1,HGF,ERBB4,MTOR,TLR4,ATRX,ELF3,BRCA1,LRRK2,POLQ,FOXA1,CHEK2,KIT,SETD2,PDGFRA,EP300,FGFR2,CCND1,SMAD4,FOXA2,USP9X,BRCA2,FGFR3,ASXL1,TGFBR2,SOX17,CDKN1A,TAF1,PPP2R1A,CBFB,ATR,SIN3A,VEZF1,CDK12,SMC1A,PTPN11,ACVR1B,MAPK8IP1,TBL1XR1,EGR3,ACVR2A,MECOM,LIFR,NCOR1,RPL5,SMAD2,AXIN2,MIR142,RAD21,ERCC2,EZH2
GO:0045597	positive regulation of cell differentiation	6.014043766408159e-9	6.014043766408159e-9	+1	VHL,GATA3,NOTCH1,CTNNB1,ARHGAP35,RUNX1,EPHA3,AKT1,AR,SOX9,HGF,MTOR,KIT,EP300,SMAD4,TGFBR2,CBFB,VEZF1,ACVR1B,ACVR2A,SMAD2,AXIN2,MIR142,EZH2
GO:0010941	regulation of cell death	6.234603019626572e-9	6.234603019626572e-9	+1	TP53,PIK3CA,PTEN,APC,VHL,EGFR,NF1,PIK3R1,CDKN2A,GATA3,NOTCH1,FBXW7,CTNNB1,FLT3,NFE2L2,NPM1,TBX3,AKT1,BRAF,AR,SOX9,ATM,CDKN1B,WT1,HGF,TLR4,BRCA1,LRRK2,FOXA1,FGFR2,EGR3,MECOM,AXIN2
GO:0007166	cell surface receptor signaling pathway	7.755244422405055e-9	7.755244422405055e-9	+1	TP53,PIK3CA,PTEN,APC,VHL,KRAS,EGFR,PIK3R1,GATA3,NOTCH1,FBXW7,CTNNB1,MAP3K1,FLT3,RUNX1,NRAS,STK11,CEBPA,EPHA3,AKT1,AR,SOX9,HGF,ERBB4,TLR4,ELF3,BRCA1,LRRK2,KIT,PDGFRA,EP300,FGFR2,CCND1,SMAD4,USP9X,FGFR3,TGFBR2,SOX17,CDKN1A,PPP2R1A,CBFB,PTPN11,ACVR1B,TBL1XR1,ACVR2A,LIFR,SMAD2,AXIN2
GO:0007167	enzyme linked receptor protein signaling pathway	8.343182445908998e-9	8.343182445908998e-9	+1	PIK3CA,APC,EGFR,PIK3R1,GATA3,NOTCH1,FBXW7,FLT3,STK11,EPHA3,AKT1,SOX9,HGF,ERBB4,KIT,PDGFRA,EP300,FGFR2,SMAD4,USP9X,FGFR3,TGFBR2,PTPN11,ACVR1B,ACVR2A,LIFR,SMAD2
GO:0006259	DNA metabolic process	1.1373702391415492e-8	1.1373702391415492e-8	+1	TP53,EGFR,CDKN2A,DNMT3A,NPM1,CRIPAK,AKT1,ATM,WT1,HGF,TET2,ATRX,BRCA1,POLQ,CHEK2,HIST1H1C,SETD2,EP300,USP9X,BRCA2,ATR,SMC1A,AXIN2,RAD21,ERCC2
GO:1901987	regulation of cell cycle phase transition	1.4081258330487947e-8	1.4081258330487947e-8	+1	TP53,PTEN,APC,CDKN2A,RB1,FBXW7,NPM1,ATM,CDKN1B,BRCA1,CHEK2,EP300,CCND1,CDKN1A,TAF1,PPP2R1A,ERCC2,EZH2
GO:0071407	cellular response to organic cyclic compound	1.4496471222826447e-8	1.4496471222826447e-8	+1	ARID1A,EGFR,RB1,CTNNB1,CDH1,NPM1,RUNX1,CRIPAK,AR,WT1,BRCA1,LRRK2,FOXA1,EP300,TAF1,CBFB,NCOR1
GO:0051896	regulation of protein kinase B signaling	1.6465316969637708e-8	1.6465316969637708e-8	+1	PIK3CA,PTEN,EGFR,PIK3R1,GATA3,AKT1,PIK3CG,HGF,ERBB4,KIT,PDGFRA,FGFR2,FGFR3,PTPN11
GO:0018022	peptidyl-lysine methylation	1.71472421287329e-8	1.71472421287329e-8	+1	CTNNB1,KDM6A,TET2,ATRX,BRCA1,HIST1H1C,SETD2,SMAD4,NSD1,EZH2
GO:0044843	cell cycle G1/S phase transition	1.7947008746418868e-8	1.7947008746418868e-8	+1	TP53,PTEN,CDKN2A,RB1,FBXW7,ATM,CDKN1B,CHEK2,EP300,CCND1,CDKN1A,TAF1,ACVR1B,CDKN2C,EZH2
GO:0016570	histone modification	2.044376335696783e-8	2.044376335696783e-8	+1	CTNNB1,BAP1,KDM6A,KDM5C,TET2,ATRX,BRCA1,HIST1H1C,SETD2,EP300,SMAD4,BRCA2,ASXL1,SIN3A,NSD1,TBL1XR1,EZH2
GO:0002520	immune system development	2.044376335696783e-8	2.044376335696783e-8	+1	CDKN2A,GATA3,NOTCH1,FBXW7,FLT3,RUNX1,CEBPA,ATM,MTOR,TLR4,TET2,POLQ,KIT,PDGFRA,EP300,FGFR2,TGFBR2,CBFB,SIN3A,ACVR1B,ACVR2A,MECOM
GO:0001558	regulation of cell growth	2.3527362738530765e-8	2.3527362738530765e-8	+1	TP53,EGFR,CDKN2A,BAP1,STK11,AKT1,CDKN1B,WT1,MTOR,SMAD4,SOX17,CDKN1A,PPP2R1A,ACVR1B,H3F3C,CDKN2C
GO:0030097	hemopoiesis	2.4847883446953145e-8	2.4847883446953145e-8	+1	CDKN2A,GATA3,NOTCH1,FBXW7,FLT3,RUNX1,CEBPA,ATM,MTOR,TLR4,TET2,KIT,PDGFRA,EP300,FGFR2,TGFBR2,CBFB,SIN3A,ACVR1B,ACVR2A,MECOM
GO:0070371	ERK1 and ERK2 cascade	2.5639456783817295e-8	2.5639456783817295e-8	+1	PTEN,EGFR,NOTCH1,FBXW7,FLT3,BRAF,SOX9,ERBB4,TLR4,KIT,PDGFRA,FGFR2,SMAD4,FGFR3,PTPN11
GO:1902533	positive regulation of intracellular signal transduction	2.601666127305356e-8	2.601666127305356e-8	+1	TP53,PIK3CA,EGFR,PIK3R1,GATA3,NOTCH1,FBXW7,FLT3,MAP2K4,AKT1,BRAF,PIK3CG,SOX9,ATM,HGF,ERBB4,TLR4,LRRK2,KIT,PDGFRA,FGFR2,FGFR3,ATR,PTPN11,MAPK8IP1,EZH2
GO:0010718	positive regulation of epithelial to mesenchymal transition	2.6225039343880445e-8	2.6225039343880445e-8	+1	NOTCH1,CTNNB1,MTOR,SMAD4,TGFBR2,SMAD2,AXIN2,EZH2
GO:0000278	mitotic cell cycle	2.709180239135476e-8	2.709180239135476e-8	+1	TP53,PTEN,APC,PBRM1,CDKN2A,RB1,CTNNB1,STAG2,AJUBA,ATM,CDKN1B,HGF,ATRX,FOXA1,CHEK2,SETD2,EP300,CCND1,BRCA2,CDKN1A,PPP2R1A,SMC1A,ACVR1B,SMC3,ERCC2,CDKN2C
GO:0007059	chromosome segregation	3.279082579798435e-8	3.279082579798435e-8	+1	APC,RB1,FBXW7,CTNNB1,CTCF,STAG2,ATM,ATRX,BRCA1,PPP2R1A,SMC1A,SMC3,AXIN2,RAD21,ERCC2
GO:0044087	regulation of cellular component biogenesis	3.474608726322307e-8	3.474608726322307e-8	+1	TP53,PTEN,APC,NAV3,RB1,NOTCH1,ARHGAP35,NPM1,RUNX1,EPHA3,STAG2,AJUBA,ATM,TLR4,BRCA1,LRRK2,EP300,SMAD4,CBFB,ATR,SMC1A,PTPN11,SMC3,ERCC2
GO:0016571	histone methylation	3.6144996703647325e-8	3.6144996703647325e-8	+1	CTNNB1,KDM6A,TET2,ATRX,BRCA1,HIST1H1C,SETD2,SMAD4,NSD1,EZH2
GO:0016569	covalent chromatin modification	3.742089651481357e-8	3.742089651481357e-8	+1	CTNNB1,BAP1,KDM6A,KDM5C,TET2,ATRX,BRCA1,HIST1H1C,SETD2,EP300,SMAD4,BRCA2,ASXL1,SIN3A,NSD1,TBL1XR1,EZH2
GO:0043491	protein kinase B signaling	3.78418054087104e-8	3.78418054087104e-8	+1	PIK3CA,PTEN,EGFR,PIK3R1,GATA3,AKT1,PIK3CG,HGF,ERBB4,KIT,PDGFRA,FGFR2,FGFR3,PTPN11
GO:0008284	positive regulation of cell population proliferation	3.943318503792748e-8	3.943318503792748e-8	+1	PTEN,KRAS,EGFR,NOTCH1,CTNNB1,FLT3,NPM1,NRAS,TBX3,AKT1,AR,SOX9,ERBB4,KIT,PDGFRA,FGFR2,CCND1,FGFR3,TGFBR2,CDKN1A,EGR3,LIFR,EZH2
GO:0048534	hematopoietic or lymphoid organ development	3.948846033687652e-8	3.948846033687652e-8	+1	CDKN2A,GATA3,NOTCH1,FBXW7,FLT3,RUNX1,CEBPA,ATM,MTOR,TLR4,TET2,KIT,PDGFRA,EP300,FGFR2,TGFBR2,CBFB,SIN3A,ACVR1B,ACVR2A,MECOM
GO:0033993	response to lipid	4.292496510389826e-8	4.292496510389826e-8	+1	ARID1A,EGFR,RB1,CTNNB1,RUNX1,IDH1,CRIPAK,EPHA3,AR,SOX9,ATM,TLR4,BRCA1,FOXA1,EP300,ASXL1,TGFBR2,CBFB,NCOR1,SMAD2
GO:0009894	regulation of catabolic process	4.88085454116548e-8	4.88085454116548e-8	+1	PIK3CA,PTEN,APC,EGFR,CDKN2A,FBXW7,KEAP1,NFE2L2,NPM1,IDH1,STK11,CEBPA,AKT1,ATM,CDKN1B,HGF,MTOR,LRRK2,CHEK2,EP300,TAF1,NCOR1,RPL5,AXIN2
GO:0033673	negative regulation of kinase activity	5.156384392970064e-8	5.156384392970064e-8	+1	APC,NF1,CDKN2A,RB1,NPM1,CRIPAK,CEBPA,AKT1,CDKN1B,FOXA2,CDKN1A,PPP2R1A,MAPK8IP1
GO:0009725	response to hormone	5.156384392970064e-8	5.156384392970064e-8	+1	PIK3CA,APC,ARID1A,EGFR,PIK3R1,RB1,NOTCH1,CTNNB1,RUNX1,IDH1,CRIPAK,AKT1,AR,WT1,BRCA1,FOXA1,EP300,CCND1,CBFB,PTPN11,NCOR1
GO:0071214	cellular response to abiotic stimulus	5.723523667134757e-8	5.723523667134757e-8	+1	TP53,PTEN,GATA3,MAP3K1,NPM1,MAP2K4,STK11,SOX9,ATM,TLR4,EP300,CDKN1A,TAF1,ATR
GO:0104004	cellular response to environmental stimulus	5.723523667134757e-8	5.723523667134757e-8	+1	TP53,PTEN,GATA3,MAP3K1,NPM1,MAP2K4,STK11,SOX9,ATM,TLR4,EP300,CDKN1A,TAF1,ATR
GO:0030518	intracellular steroid hormone receptor signaling pathway	5.723523667134757e-8	5.723523667134757e-8	+1	ARID1A,RB1,CTNNB1,RUNX1,CRIPAK,AR,BRCA1,FOXA1,EP300,CBFB,NCOR1
GO:0043067	regulation of programmed cell death	6.14624126404319e-8	6.14624126404319e-8	+1	TP53,PIK3CA,PTEN,APC,VHL,EGFR,NF1,PIK3R1,CDKN2A,GATA3,NOTCH1,FBXW7,CTNNB1,FLT3,NFE2L2,NPM1,TBX3,AKT1,BRAF,AR,SOX9,ATM,WT1,HGF,BRCA1,LRRK2,FOXA1,FGFR2,EGR3,MECOM
GO:0051897	positive regulation of protein kinase B signaling	6.19071591877934e-8	6.19071591877934e-8	+1	PIK3CA,EGFR,PIK3R1,GATA3,PIK3CG,HGF,ERBB4,KIT,PDGFRA,FGFR2,FGFR3,PTPN11
GO:0072331	signal transduction by p53 class mediator	6.46292471355074e-8	6.46292471355074e-8	+1	TP53,STK11,AKT1,ATM,CDKN1B,ATRX,BRCA1,CHEK2,EP300,CDKN1A,TAF1,ATR,RPL5
GO:0032501	multicellular organismal process	6.828447844875517e-8	6.828447844875517e-8	+1	TP53,PIK3CA,PTEN,APC,NAV3,EGFR,NF1,PIK3R1,CDKN2A,GATA3,RB1,NOTCH1,FBXW7,CTNNB1,FLT3,TSHZ3,CDH1,ARHGAP35,RUNX1,TBX3,STK11,CEBPA,EPHA3,AKT1,BRAF,AR,EPPK1,PIK3CG,SOX9,ATM,CDKN1B,WT1,HGF,PRX,ERBB4,MTOR,TLR4,ARID5B,TET2,ELF3,BRCA1,LRRK2,POLQ,FOXA1,KIT,SETD2,PDGFRA,EP300,FGFR2,SMAD4,FOXA2,USP9X,BRCA2,FGFR3,ASXL1,TGFBR2,SOX17,CDKN1A,TAF1,CBFB,ATR,SIN3A,VEZF1,PTPN11,ACVR1B,EGR3,ACVR2A,MECOM,SMAD2,AXIN2,MIR142,ERCC2,EZH2
GO:0022607	cellular component assembly	7.120398731242367e-8	7.120398731242367e-8	+1	TP53,PTEN,APC,NAV3,CDKN2A,RB1,NOTCH1,CTNNB1,CDH1,ARHGAP35,CTCF,NPM1,RUNX1,EPHA3,STAG2,AR,AJUBA,EPPK1,SOX9,ATM,TLR4,ATRX,BRCA1,LRRK2,POLQ,CHEK2,KIT,HIST1H1C,PDGFRA,EP300,SMAD4,SF3B1,TAF1,PPP2R1A,CBFB,ATR,HIST1H2BD,SMC1A,PTPN11,H3F3C,SMC3,NCOR1,RPL5,SMAD2,AXIN2,ERCC2
GO:0043069	negative regulation of programmed cell death	7.14048187775429e-8	7.14048187775429e-8	+1	TP53,PIK3CA,VHL,EGFR,PIK3R1,GATA3,NOTCH1,CTNNB1,NFE2L2,NPM1,TBX3,AKT1,BRAF,AR,SOX9,WT1,HGF,BRCA1,LRRK2,FGFR2,EGR3,MECOM
GO:0051093	negative regulation of developmental process	7.14048187775429e-8	7.14048187775429e-8	+1	PTEN,EGFR,NF1,CDKN2A,GATA3,RB1,NOTCH1,FBXW7,CTNNB1,RUNX1,TBX3,SOX9,CDKN1B,WT1,TLR4,FOXA1,SMAD4,FOXA2,BRCA2,FGFR3,ASXL1,CDKN1A,CBFB
GO:0045787	positive regulation of cell cycle	7.603166306940856e-8	7.603166306940856e-8	+1	TP53,RB1,NPM1,TBX3,ATM,CDKN1B,ATRX,BRCA1,FOXA1,CHEK2,EP300,FGFR2,CCND1,CDKN1A,RAD21,EZH2
GO:0044093	positive regulation of molecular function	7.661500136506428e-8	7.661500136506428e-8	+1	PTEN,EGFR,NF1,CDKN2A,GATA3,RB1,FBXW7,CTNNB1,MAP3K1,FLT3,NPM1,MAP2K4,STK11,AKT1,AR,PIK3CG,MTOR,TLR4,ARID5B,LRRK2,FOXA1,KIT,PDGFRA,EP300,FGFR2,CCND1,FGFR3,TGFBR2,CDKN1A,TAF1,EZH2
GO:0043401	steroid hormone mediated signaling pathway	7.661500136506428e-8	7.661500136506428e-8	+1	ARID1A,RB1,CTNNB1,RUNX1,CRIPAK,AR,BRCA1,FOXA1,EP300,CBFB,NCOR1
GO:0071363	cellular response to growth factor stimulus	7.923447287820245e-8	7.923447287820245e-8	+1	EGFR,GATA3,NOTCH1,CTNNB1,STK11,AKT1,SOX9,HGF,PDGFRA,EP300,FGFR2,SMAD4,USP9X,FGFR3,TGFBR2,PTPN11,ACVR1B,EGR3,ACVR2A,SMAD2
GO:0030879	mammary gland development	8.041636668055082e-8	8.041636668055082e-8	+1	GATA3,ARHGAP35,TBX3,AKT1,ERBB4,ELF3,FGFR2,BRCA2
GO:0071824	protein-DNA complex subunit organization	8.38384961874645e-8	8.38384961874645e-8	+1	TP53,ARID1A,PBRM1,RB1,CTCF,NPM1,SOX9,ATRX,HIST1H1C,SETD2,TAF1,HIST1H2BD,H3F3C,ERCC2
GO:1902806	regulation of cell cycle G1/S phase transition	8.390512179011032e-8	8.390512179011032e-8	+1	TP53,PTEN,RB1,FBXW7,ATM,CDKN1B,CHEK2,EP300,CCND1,CDKN1A,TAF1,EZH2
GO:0050821	protein stabilization	8.954906845147786e-8	8.954906845147786e-8	+1	PTEN,VHL,PIK3R1,CDKN2A,FBXW7,CHEK2,EP300,USP9X,SOX17,CDKN1A,TAF1,RPL5
GO:0051248	negative regulation of protein metabolic process	9.594301224293115e-8	9.594301224293115e-8	+1	PTEN,APC,EGFR,NF1,CDKN2A,RB1,CTNNB1,NPM1,CRIPAK,CEBPA,AKT1,CDKN1B,HGF,TLR4,BRCA1,LRRK2,SMAD4,CDKN1A,TAF1,PPP2R1A,SIN3A,MAPK8IP1,MECOM,NCOR1,RPL5
GO:0070372	regulation of ERK1 and ERK2 cascade	9.67242502881104e-8	9.67242502881104e-8	+1	PTEN,EGFR,NOTCH1,FBXW7,FLT3,BRAF,ERBB4,TLR4,KIT,PDGFRA,FGFR2,SMAD4,FGFR3,PTPN11
GO:0000819	sister chromatid segregation	1.1611042073253773e-7	1.1611042073253773e-7	+1	APC,RB1,FBXW7,CTNNB1,CTCF,STAG2,ATM,ATRX,SMC1A,SMC3,AXIN2,RAD21
GO:0070848	response to growth factor	1.303717807061315e-7	1.303717807061315e-7	+1	EGFR,GATA3,NOTCH1,CTNNB1,STK11,AKT1,SOX9,HGF,PDGFRA,EP300,FGFR2,SMAD4,USP9X,FGFR3,TGFBR2,PTPN11,ACVR1B,EGR3,ACVR2A,SMAD2
GO:0051240	positive regulation of multicellular organismal process	1.310373519871615e-7	1.310373519871615e-7	+1	PTEN,APC,GATA3,NOTCH1,CTNNB1,ARHGAP35,RUNX1,EPHA3,AKT1,SOX9,WT1,HGF,ERBB4,MTOR,TLR4,BRCA1,KIT,SETD2,EP300,FGFR2,SMAD4,FOXA2,TGFBR2,CBFB,PTPN11,ACVR1B,ACVR2A,SMAD2,AXIN2,MIR142,EZH2
GO:0032870	cellular response to hormone stimulus	1.3467315745359582e-7	1.3467315745359582e-7	+1	PIK3CA,APC,ARID1A,EGFR,PIK3R1,RB1,NOTCH1,CTNNB1,RUNX1,CRIPAK,AKT1,AR,WT1,BRCA1,FOXA1,EP300,CBFB,PTPN11,NCOR1
GO:0032269	negative regulation of cellular protein metabolic process	1.3591155314098493e-7	1.3591155314098493e-7	+1	PTEN,APC,NF1,CDKN2A,RB1,CTNNB1,NPM1,CRIPAK,CEBPA,AKT1,CDKN1B,HGF,TLR4,BRCA1,LRRK2,SMAD4,CDKN1A,TAF1,PPP2R1A,SIN3A,MAPK8IP1,MECOM,NCOR1,RPL5
GO:0033674	positive regulation of kinase activity	1.4399399140215304e-7	1.4399399140215304e-7	+1	EGFR,FBXW7,MAP3K1,FLT3,MAP2K4,STK11,AKT1,PIK3CG,MTOR,TLR4,LRRK2,KIT,PDGFRA,CCND1,FGFR3,TGFBR2,CDKN1A,EZH2
GO:0007063	regulation of sister chromatid cohesion	1.4560808670957746e-7	1.4560808670957746e-7	+1	RB1,CTNNB1,CTCF,ATRX,AXIN2,RAD21
GO:0006974	cellular response to DNA damage stimulus	1.4560808670957746e-7	1.4560808670957746e-7	+1	TP53,APC,EGFR,NPM1,STK11,CRIPAK,ATM,CDKN1B,ATRX,BRCA1,POLQ,CHEK2,SETD2,EP300,CCND1,BRCA2,CDKN1A,TAF1,ATR,SMC1A,AXIN2,RAD21,ERCC2
GO:0014066	regulation of phosphatidylinositol 3-kinase signaling	1.5336934657551856e-7	1.5336934657551856e-7	+1	PIK3CA,PTEN,EGFR,PIK3R1,FLT3,PIK3CG,SOX9,HGF,KIT,PDGFRA
GO:0042981	regulation of apoptotic process	1.6982620446776275e-7	1.6982620446776275e-7	+1	TP53,PIK3CA,PTEN,APC,VHL,EGFR,NF1,PIK3R1,CDKN2A,GATA3,NOTCH1,FBXW7,CTNNB1,FLT3,NFE2L2,NPM1,TBX3,AKT1,BRAF,AR,SOX9,ATM,WT1,HGF,BRCA1,LRRK2,FOXA1,FGFR2,EGR3
GO:0030308	negative regulation of cell growth	1.8276100088526013e-7	1.8276100088526013e-7	+1	TP53,CDKN2A,STK11,CDKN1B,WT1,SMAD4,SOX17,CDKN1A,PPP2R1A,ACVR1B,CDKN2C
GO:0006469	negative regulation of protein kinase activity	1.876249059591154e-7	1.876249059591154e-7	+1	APC,NF1,CDKN2A,RB1,NPM1,CRIPAK,CEBPA,AKT1,CDKN1B,CDKN1A,PPP2R1A,MAPK8IP1
GO:0009416	response to light stimulus	1.9849873621306212e-7	1.9849873621306212e-7	+1	TP53,EGFR,NF1,NPM1,STK11,CRIPAK,AKT1,EP300,CCND1,CDKN1A,TAF1,ATR,ERCC2
GO:0006260	DNA replication	2.2070477697672325e-7	2.2070477697672325e-7	+1	EGFR,FBXW7,STAG2,ATM,ATRX,BRCA1,POLQ,CHEK2,BRCA2,PPP2R1A,ATR,SMC1A,SMC3
GO:0051347	positive regulation of transferase activity	2.366714740264551e-7	2.366714740264551e-7	+1	PTEN,EGFR,FBXW7,MAP3K1,FLT3,MAP2K4,STK11,AKT1,PIK3CG,MTOR,TLR4,LRRK2,KIT,PDGFRA,CCND1,FGFR3,TGFBR2,CDKN1A,EZH2
GO:0018205	peptidyl-lysine modification	2.48286019464208e-7	2.48286019464208e-7	+1	CDKN2A,CTNNB1,KDM6A,TET2,ATRX,BRCA1,HIST1H1C,SETD2,EP300,SMAD4,BRCA2,SIN3A,NSD1,EZH2
GO:0043066	negative regulation of apoptotic process	2.5271252252072264e-7	2.5271252252072264e-7	+1	TP53,PIK3CA,VHL,EGFR,PIK3R1,GATA3,NOTCH1,CTNNB1,NFE2L2,NPM1,TBX3,AKT1,BRAF,AR,SOX9,WT1,HGF,BRCA1,LRRK2,FGFR2,EGR3
GO:0030522	intracellular receptor signaling pathway	2.6994864508017385e-7	2.6994864508017385e-7	+1	ARID1A,RB1,CTNNB1,RUNX1,CRIPAK,AR,BRCA1,FOXA1,EP300,ASXL1,CBFB,NCOR1,EZH2
GO:1901700	response to oxygen-containing compound	2.7213925009872347e-7	2.7213925009872347e-7	+1	TP53,PIK3CA,APC,EGFR,PIK3R1,CTNNB1,CDH1,NFE2L2,EPHA3,AKT1,SOX9,ATM,WT1,HGF,MTOR,TLR4,BRCA1,LRRK2,FOXA1,PDGFRA,FOXA2,ASXL1,TGFBR2,TAF1,PTPN11,SMAD2
GO:0090399	replicative senescence	2.8829513704396466e-7	2.8829513704396466e-7	+1	TP53,CDKN2A,ATM,CHEK2,ATR
GO:0030155	regulation of cell adhesion	3.044220311992788e-7	3.044220311992788e-7	+1	PIK3CA,PTEN,NF1,PIK3R1,CDKN2A,GATA3,NOTCH1,CDH1,RUNX1,EPHA3,AKT1,PIK3CG,ATM,FOXA1,FOXA2,TGFBR2,PPP2R1A,CBFB,PTPN11
GO:0006275	regulation of DNA replication	3.044220311992788e-7	3.044220311992788e-7	+1	EGFR,FBXW7,STAG2,ATRX,CHEK2,PPP2R1A,ATR,SMC1A,SMC3
GO:0060548	negative regulation of cell death	3.047370107959917e-7	3.047370107959917e-7	+1	TP53,PIK3CA,VHL,EGFR,PIK3R1,GATA3,NOTCH1,CTNNB1,NFE2L2,NPM1,TBX3,AKT1,BRAF,AR,SOX9,WT1,HGF,BRCA1,LRRK2,FGFR2,EGR3,MECOM
GO:0048545	response to steroid hormone	3.1308966280164585e-7	3.1308966280164585e-7	+1	ARID1A,RB1,CTNNB1,RUNX1,IDH1,CRIPAK,AR,BRCA1,FOXA1,EP300,CBFB,NCOR1
GO:0043086	negative regulation of catalytic activity	3.8344586650850913e-7	3.8344586650850913e-7	+1	TP53,APC,NF1,CDKN2A,RB1,NOTCH1,NPM1,CRIPAK,CEBPA,AKT1,CDKN1B,HGF,LRRK2,FOXA2,CDKN1A,PPP2R1A,EIF4A2,MAPK8IP1,RPL5
GO:0033044	regulation of chromosome organization	4.194462980302221e-7	4.194462980302221e-7	+1	APC,RB1,CTNNB1,CTCF,ATM,ATRX,BRCA1,HIST1H1C,SMAD4,ATR,SIN3A,NSD1,AXIN2,RAD21
GO:0070647	protein modification by small protein conjugation or removal	4.2092700553995305e-7	4.2092700553995305e-7	+1	TP53,PTEN,APC,VHL,CDKN2A,GATA3,FBXW7,CTNNB1,KEAP1,NFE2L2,BAP1,CRIPAK,AKT1,AR,BRCA1,LRRK2,SMAD4,USP9X,ASXL1,TAF1,CBFB,HIST1H2BD,RPL5,SMAD2
GO:0008213	protein alkylation	4.690926800051288e-7	4.690926800051288e-7	+1	CTNNB1,KDM6A,TET2,ATRX,BRCA1,HIST1H1C,SETD2,SMAD4,NSD1,EZH2
GO:0006479	protein methylation	4.690926800051288e-7	4.690926800051288e-7	+1	CTNNB1,KDM6A,TET2,ATRX,BRCA1,HIST1H1C,SETD2,SMAD4,NSD1,EZH2
GO:0071383	cellular response to steroid hormone stimulus	5.232283014000132e-7	5.232283014000132e-7	+1	ARID1A,RB1,CTNNB1,RUNX1,CRIPAK,AR,BRCA1,FOXA1,EP300,CBFB,NCOR1
GO:0007346	regulation of mitotic cell cycle	5.66860077875441e-7	5.66860077875441e-7	+1	TP53,PTEN,APC,CDKN2A,RB1,CTNNB1,STAG2,ATM,CDKN1B,ATRX,FOXA1,CHEK2,EP300,CCND1,CDKN1A,PPP2R1A,SMC1A,SMC3,ERCC2
GO:1903047	mitotic cell cycle process	5.759815147284365e-7	5.759815147284365e-7	+1	TP53,PTEN,APC,CDKN2A,RB1,STAG2,AJUBA,ATM,CDKN1B,ATRX,CHEK2,SETD2,EP300,CCND1,BRCA2,CDKN1A,PPP2R1A,SMC1A,ACVR1B,SMC3,ERCC2,CDKN2C
GO:0044085	cellular component biogenesis	6.155465004231361e-7	6.155465004231361e-7	+1	TP53,PTEN,APC,NAV3,CDKN2A,RB1,NOTCH1,CTNNB1,CDH1,ARHGAP35,CTCF,NPM1,RUNX1,EPHA3,STAG2,AR,AJUBA,EPPK1,SOX9,ATM,TLR4,ATRX,BRCA1,LRRK2,POLQ,CHEK2,KIT,HIST1H1C,PDGFRA,EP300,SMAD4,SF3B1,TAF1,PPP2R1A,CBFB,ATR,HIST1H2BD,SMC1A,PTPN11,H3F3C,SMC3,NCOR1,RPL5,SMAD2,AXIN2,ERCC2
GO:0043410	positive regulation of MAPK cascade	6.604059470516591e-7	6.604059470516591e-7	+1	EGFR,NOTCH1,FBXW7,FLT3,MAP2K4,BRAF,PIK3CG,ERBB4,TLR4,LRRK2,KIT,PDGFRA,FGFR2,FGFR3,PTPN11,MAPK8IP1,EZH2
GO:0031647	regulation of protein stability	7.739889485261181e-7	7.739889485261181e-7	+1	PTEN,VHL,KRAS,PIK3R1,CDKN2A,FBXW7,CHEK2,EP300,USP9X,SOX17,CDKN1A,TAF1,RPL5
GO:0090068	positive regulation of cell cycle process	8.091287672711443e-7	8.091287672711443e-7	+1	TP53,RB1,NPM1,ATM,CDKN1B,ATRX,BRCA1,CHEK2,EP300,CCND1,CDKN1A,RAD21,EZH2
GO:0097190	apoptotic signaling pathway	8.768113650044729e-7	8.768113650044729e-7	+1	TP53,PTEN,FBXW7,NFE2L2,STK11,AKT1,AR,ATM,HGF,TLR4,BRCA1,LRRK2,CHEK2,EP300,FGFR3,CDKN1A,ACVR1B
GO:1901699	cellular response to nitrogen compound	9.024228397172956e-7	9.024228397172956e-7	+1	TP53,PIK3CA,APC,PIK3R1,CTNNB1,CDH1,NPM1,AKT1,SOX9,WT1,MTOR,TLR4,ATRX,BRCA1,LRRK2,TAF1,PTPN11
GO:0006333	chromatin assembly or disassembly	9.585821797066365e-7	9.585821797066365e-7	+1	TP53,ARID1A,PBRM1,CDKN2A,CTCF,NPM1,SOX9,ATRX,HIST1H1C,HIST1H2BD,H3F3C
GO:0030330	DNA damage response, signal transduction by p53 class mediator	0.0000010795687102633125	0.0000010795687102633125	+1	TP53,ATM,CDKN1B,ATRX,BRCA1,CHEK2,EP300,CDKN1A,ATR
GO:0071396	cellular response to lipid	0.0000011031118503812759	0.0000011031118503812759	+1	ARID1A,EGFR,RB1,CTNNB1,RUNX1,CRIPAK,EPHA3,AR,SOX9,ATM,TLR4,BRCA1,FOXA1,EP300,CBFB,NCOR1
GO:0009755	hormone-mediated signaling pathway	0.000001361924210830702	0.000001361924210830702	+1	ARID1A,RB1,CTNNB1,RUNX1,CRIPAK,AR,BRCA1,FOXA1,EP300,CBFB,NCOR1
GO:1901701	cellular response to oxygen-containing compound	0.0000013755139984275227	0.0000013755139984275227	+1	TP53,PIK3CA,APC,EGFR,PIK3R1,CTNNB1,CDH1,NFE2L2,EPHA3,AKT1,SOX9,ATM,WT1,HGF,MTOR,TLR4,BRCA1,LRRK2,PDGFRA,FOXA2,TAF1,PTPN11
GO:0033045	regulation of sister chromatid segregation	0.0000013755139984275227	0.0000013755139984275227	+1	APC,RB1,CTNNB1,CTCF,ATM,ATRX,AXIN2,RAD21
GO:1905114	cell surface receptor signaling pathway involved in cell-cell signaling	0.0000014751893377834687	0.0000014751893377834687	+1	PTEN,APC,EGFR,GATA3,CTNNB1,RUNX1,STK11,AKT1,SOX9,LRRK2,FGFR2,SOX17,PPP2R1A,CBFB,TBL1XR1,AXIN2
GO:0014068	positive regulation of phosphatidylinositol 3-kinase signaling	0.0000015182295946472832	0.0000015182295946472832	+1	PIK3CA,PIK3R1,FLT3,PIK3CG,SOX9,HGF,KIT,PDGFRA
GO:0048729	tissue morphogenesis	0.0000015679345788448528	0.0000015679345788448528	+1	PTEN,GATA3,NOTCH1,CTNNB1,ARHGAP35,TBX3,SOX9,WT1,HGF,MTOR,FGFR2,SMAD4,TGFBR2,SOX17,SMAD2
GO:0032876	negative regulation of DNA endoreduplication	0.0000015848456018249044	0.0000015848456018249044	+1	FBXW7,STAG2,SMC1A,SMC3
GO:0045860	positive regulation of protein kinase activity	0.0000016082658214873092	0.0000016082658214873092	+1	EGFR,FBXW7,MAP3K1,FLT3,MAP2K4,STK11,AKT1,PIK3CG,MTOR,TLR4,LRRK2,KIT,CCND1,TGFBR2,CDKN1A,EZH2
GO:0034502	protein localization to chromosome	0.000001663988621898523	0.000001663988621898523	+1	RB1,CTCF,ATM,ATRX,SETD2,BRCA2,ATR,RAD21
GO:0030111	regulation of Wnt signaling pathway	0.0000016788138896431862	0.0000016788138896431862	+1	APC,EGFR,CTNNB1,RUNX1,STK11,SOX9,LRRK2,FGFR2,SOX17,PPP2R1A,CBFB,TBL1XR1,AXIN2
GO:2000134	negative regulation of G1/S transition of mitotic cell cycle	0.000001714117037236863	0.000001714117037236863	+1	TP53,PTEN,RB1,ATM,CDKN1B,CHEK2,EP300,CCND1,CDKN1A
GO:0007389	pattern specification process	0.000001714117037236863	0.000001714117037236863	+1	APC,NOTCH1,TBX3,WT1,ERBB4,FGFR2,FOXA2,TGFBR2,SOX17,ACVR1B,ACVR2A,SMAD2
GO:0043414	macromolecule methylation	0.000001714117037236863	0.000001714117037236863	+1	CTNNB1,DNMT3A,KDM6A,WT1,TET2,ATRX,BRCA1,HIST1H1C,SETD2,SMAD4,NSD1,EZH2
GO:0045596	negative regulation of cell differentiation	0.0000018010381065878088	0.0000018010381065878088	+1	PTEN,EGFR,NF1,CDKN2A,GATA3,RB1,NOTCH1,FBXW7,RUNX1,TBX3,SOX9,TLR4,FOXA1,SMAD4,FOXA2,ASXL1,CBFB
GO:0000079	regulation of cyclin-dependent protein serine/threonine kinase activity	0.0000018096312021636657	0.0000018096312021636657	+1	PTEN,APC,CDKN2A,CEBPA,CDKN1B,CCND1,CDKN1A,CDKN2C
GO:0019216	regulation of lipid metabolic process	0.000001875210121842136	0.000001875210121842136	+1	PIK3R1,RB1,FBXW7,FLT3,IDH1,AKT1,MTOR,BRCA1,KIT,PDGFRA,FGFR3,SIN3A,TBL1XR1,NCOR1
GO:0051241	negative regulation of multicellular organismal process	0.0000018901632943272882	0.0000018901632943272882	+1	PTEN,NAV3,EGFR,NF1,CDKN2A,GATA3,RB1,NOTCH1,FBXW7,CTNNB1,RUNX1,STK11,EPPK1,PIK3CG,SOX9,WT1,TLR4,LRRK2,FOXA1,PDGFRA,SMAD4,FOXA2,BRCA2,CBFB
GO:0070374	positive regulation of ERK1 and ERK2 cascade	0.000001929767888075759	0.000001929767888075759	+1	EGFR,NOTCH1,FBXW7,FLT3,BRAF,ERBB4,KIT,PDGFRA,FGFR2,FGFR3,PTPN11
GO:0016055	Wnt signaling pathway	0.000001931200228103708	0.000001931200228103708	+1	PTEN,APC,EGFR,GATA3,CTNNB1,RUNX1,STK11,SOX9,LRRK2,FGFR2,SOX17,PPP2R1A,CBFB,TBL1XR1,AXIN2
GO:0098813	nuclear chromosome segregation	0.000001943863748882063	0.000001943863748882063	+1	APC,RB1,FBXW7,CTNNB1,CTCF,STAG2,ATM,ATRX,SMC1A,SMC3,AXIN2,RAD21
GO:0048863	stem cell differentiation	0.0000020584690065948597	0.0000020584690065948597	+1	GATA3,NOTCH1,RUNX1,SOX9,ERBB4,KIT,SETD2,PDGFRA,FGFR2,CBFB
GO:0198738	cell-cell signaling by wnt	0.000002201515705317998	0.000002201515705317998	+1	PTEN,APC,EGFR,GATA3,CTNNB1,RUNX1,STK11,SOX9,LRRK2,FGFR2,SOX17,PPP2R1A,CBFB,TBL1XR1,AXIN2
GO:0044092	negative regulation of molecular function	0.000002392754854670459	0.000002392754854670459	+1	TP53,APC,NF1,CDKN2A,RB1,NOTCH1,KEAP1,NPM1,CRIPAK,CEBPA,AKT1,CDKN1B,HGF,LRRK2,FOXA2,CDKN1A,TAF1,PPP2R1A,SIN3A,EIF4A2,MAPK8IP1,RPL5
GO:1902807	negative regulation of cell cycle G1/S phase transition	0.0000024558707231631164	0.0000024558707231631164	+1	TP53,PTEN,RB1,ATM,CDKN1B,CHEK2,EP300,CCND1,CDKN1A
GO:0007548	sex differentiation	0.0000024558707231631164	0.0000024558707231631164	+1	GATA3,TBX3,AR,SOX9,WT1,KIT,PDGFRA,BRCA2,PTPN11
GO:0051090	regulation of DNA-binding transcription factor activity	0.0000024975796332303224	0.0000024975796332303224	+1	PTEN,CDKN2A,RB1,CTNNB1,KEAP1,NPM1,AKT1,AR,TLR4,ARID5B,FOXA1,KIT,EP300,FOXA2,TAF1
GO:0044786	cell cycle DNA replication	0.0000026431729237303983	0.0000026431729237303983	+1	FBXW7,STAG2,ATRX,CHEK2,BRCA2,SMC1A,SMC3
GO:0061458	reproductive system development	0.000002772053881436259	0.000002772053881436259	+1	GATA3,TBX3,AR,SOX9,WT1,KIT,PDGFRA,FGFR2,BRCA2,PTPN11
GO:0048608	reproductive structure development	0.000002772053881436259	0.000002772053881436259	+1	GATA3,TBX3,AR,SOX9,WT1,KIT,PDGFRA,FGFR2,BRCA2,PTPN11
GO:1904029	regulation of cyclin-dependent protein kinase activity	0.0000028237557856887606	0.0000028237557856887606	+1	PTEN,APC,CDKN2A,CEBPA,CDKN1B,CCND1,CDKN1A,CDKN2C
GO:0007569	cell aging	0.0000028237557856887606	0.0000028237557856887606	+1	TP53,CDKN2A,NPM1,TBX3,ATM,CHEK2,CDKN1A,ATR
GO:0000082	G1/S transition of mitotic cell cycle	0.000002881057383548183	0.000002881057383548183	+1	TP53,PTEN,CDKN2A,RB1,ATM,CDKN1B,CHEK2,EP300,CCND1,CDKN1A,ACVR1B,CDKN2C
GO:0042060	wound healing	0.0000029137434679771994	0.0000029137434679771994	+1	PIK3CA,PTEN,NF1,PIK3R1,GATA3,ARHGAP35,EPPK1,PIK3CG,CDKN1B,ERBB4,MTOR,TLR4,PDGFRA,FOXA2,CDKN1A,PTPN11
GO:0032259	methylation	0.00000300038539493467	0.00000300038539493467	+1	CTNNB1,DNMT3A,KDM6A,WT1,TET2,ATRX,BRCA1,HIST1H1C,SETD2,SMAD4,NSD1,EZH2
GO:0008156	negative regulation of DNA replication	0.000003172634768070012	0.000003172634768070012	+1	FBXW7,STAG2,CHEK2,ATR,SMC1A,SMC3
GO:0007568	aging	0.0000032208046791113097	0.0000032208046791113097	+1	TP53,CDKN2A,NPM1,TBX3,ATM,LRRK2,CHEK2,CDKN1A,ATR
GO:0018108	peptidyl-tyrosine phosphorylation	0.000003574862917087508	0.000003574862917087508	+1	TP53,EGFR,FBXW7,FLT3,EPHA3,HGF,ERBB4,KIT,PDGFRA,FGFR2,FGFR3,PPP2R1A
GO:1901796	regulation of signal transduction by p53 class mediator	0.000003711870883960862	0.000003711870883960862	+1	TP53,STK11,AKT1,ATM,CHEK2,EP300,TAF1,ATR,RPL5
GO:0030099	myeloid cell differentiation	0.0000037186825037502406	0.0000037186825037502406	+1	FBXW7,RUNX1,CEBPA,MTOR,TLR4,TET2,KIT,EP300,TGFBR2,CBFB,SIN3A,ACVR1B,ACVR2A
GO:0060070	canonical Wnt signaling pathway	0.000004046338494846709	0.000004046338494846709	+1	PTEN,APC,EGFR,GATA3,CTNNB1,STK11,SOX9,LRRK2,FGFR2,SOX17,TBL1XR1,AXIN2
GO:0018212	peptidyl-tyrosine modification	0.000004046338494846709	0.000004046338494846709	+1	TP53,EGFR,FBXW7,FLT3,EPHA3,HGF,ERBB4,KIT,PDGFRA,FGFR2,FGFR3,PPP2R1A
GO:0009790	embryo development	0.000004346159824952479	0.000004346159824952479	+1	GATA3,NOTCH1,CTNNB1,TBX3,SOX9,WT1,ERBB4,BRCA1,KIT,SETD2,PDGFRA,FGFR2,FOXA2,TGFBR2,SOX17,SMAD2
GO:1901988	negative regulation of cell cycle phase transition	0.000004442046097393407	0.000004442046097393407	+1	TP53,PTEN,APC,RB1,ATM,CDKN1B,BRCA1,CHEK2,EP300,CCND1,CDKN1A
GO:0032875	regulation of DNA endoreduplication	0.000005027446823945326	0.000005027446823945326	+1	FBXW7,STAG2,SMC1A,SMC3
GO:0000075	cell cycle checkpoint	0.000005136652732274837	0.000005136652732274837	+1	TP53,APC,RB1,ATM,CDKN1B,BRCA1,CHEK2,EP300,CCND1,CDKN1A,ATR
GO:0034728	nucleosome organization	0.000005137140933340763	0.000005137140933340763	+1	ARID1A,PBRM1,CTCF,NPM1,SOX9,ATRX,HIST1H1C,SETD2,HIST1H2BD,H3F3C
GO:2000058	regulation of ubiquitin-dependent protein catabolic process	0.000005168839326111983	0.000005168839326111983	+1	PTEN,CDKN2A,FBXW7,KEAP1,NFE2L2,CEBPA,LRRK2,TAF1,RPL5
GO:0071417	cellular response to organonitrogen compound	0.000005348851370265855	0.000005348851370265855	+1	TP53,PIK3CA,APC,PIK3R1,CTNNB1,CDH1,AKT1,SOX9,WT1,MTOR,TLR4,BRCA1,LRRK2,TAF1,PTPN11
GO:0001655	urogenital system development	0.000005397158470832603	0.000005397158470832603	+1	NF1,GATA3,CTNNB1,AR,SOX9,WT1,LRRK2,PDGFRA,FGFR2,SOX17
GO:1904030	negative regulation of cyclin-dependent protein kinase activity	0.000005576096193448672	0.000005576096193448672	+1	APC,CDKN2A,CEBPA,CDKN1B,CDKN1A
GO:1903827	regulation of cellular protein localization	0.000005650135268762016	0.000005650135268762016	+1	TP53,APC,EGFR,PIK3R1,RB1,FBXW7,CTNNB1,CDH1,BAP1,EPHA3,AKT1,AR,LRRK2,SETD2,SIN3A
GO:0044819	mitotic G1/S transition checkpoint	0.000005655706281489534	0.000005655706281489534	+1	TP53,ATM,CDKN1B,CHEK2,EP300,CCND1,CDKN1A
GO:0051054	positive regulation of DNA metabolic process	0.000005655706281489534	0.000005655706281489534	+1	EGFR,AKT1,ATM,WT1,HGF,ATRX,BRCA1,USP9X,ATR,ERCC2
GO:0031571	mitotic G1 DNA damage checkpoint	0.000005655706281489534	0.000005655706281489534	+1	TP53,ATM,CDKN1B,CHEK2,EP300,CCND1,CDKN1A
GO:0042770	signal transduction in response to DNA damage	0.0000061938896721584645	0.0000061938896721584645	+1	TP53,ATM,CDKN1B,ATRX,BRCA1,CHEK2,EP300,CDKN1A,ATR
GO:2000027	regulation of animal organ morphogenesis	0.0000061938896721584645	0.0000061938896721584645	+1	GATA3,NOTCH1,FBXW7,CTNNB1,SOX9,WT1,HGF,FGFR2,TGFBR2
GO:0044783	G1 DNA damage checkpoint	0.000006257469222258599	0.000006257469222258599	+1	TP53,ATM,CDKN1B,CHEK2,EP300,CCND1,CDKN1A
GO:0044772	mitotic cell cycle phase transition	0.000006257469222258599	0.000006257469222258599	+1	TP53,PTEN,APC,CDKN2A,RB1,AJUBA,ATM,CDKN1B,CHEK2,EP300,CCND1,CDKN1A,PPP2R1A,ACVR1B,ERCC2,CDKN2C
GO:0006281	DNA repair	0.000006799948038445265	0.000006799948038445265	+1	TP53,EGFR,NPM1,CRIPAK,ATM,BRCA1,POLQ,CHEK2,SETD2,EP300,BRCA2,ATR,SMC1A,AXIN2,RAD21,ERCC2
GO:0009987	cellular process	0.000007577091597752565	0.000007577091597752565	+1	TP53,PIK3CA,PTEN,APC,VHL,KRAS,ARID1A,PBRM1,NAV3,EGFR,NF1,PIK3R1,CDKN2A,GATA3,RB1,NOTCH1,FBXW7,CTNNB1,DNMT3A,MAP3K1,FLT3,TSHZ3,KEAP1,CDH1,ARHGAP35,CTCF,NFE2L2,BAP1,NPM1,RUNX1,NRAS,IDH1,TBX3,MAP2K4,STK11,CRIPAK,CEBPA,KDM6A,EPHA3,AKT1,STAG2,BRAF,AR,AJUBA,EPPK1,TSHZ2,PIK3CG,SOX9,ATM,CDKN1B,WT1,HGF,KDM5C,PRX,ERBB4,MTOR,TLR4,U2AF1,ARID5B,TET2,ATRX,ELF3,BRCA1,LRRK2,POLQ,FOXA1,IDH2,CHEK2,KIT,HIST1H1C,SETD2,PDGFRA,EP300,FGFR2,CCND1,SMAD4,FOXA2,USP9X,BRCA2,NFE2L3,FGFR3,ASXL1,TGFBR2,SOX17,CDKN1A,B4GALT3,SF3B1,TAF1,PPP2R1A,CBFB,ATR,SIN3A,VEZF1,HIST1H2BD,EIF4A2,CDK12,PHF6,SMC1A,PTPN11,ACVR1B,MAPK8IP1,H3F3C,NSD1,TBL1XR1,EGR3,ACVR2A,MECOM,LIFR,SMC3,NCOR1,RPL5,SMAD2,SPOP,AXIN2,MIR142,RAD21,ERCC2,CDKN2C,EZH2,PCBP1
GO:0002244	hematopoietic progenitor cell differentiation	0.000007658492320251173	0.000007658492320251173	+1	GATA3,NOTCH1,FLT3,RUNX1,KIT,PDGFRA,CBFB
GO:0030521	androgen receptor signaling pathway	0.000007658492320251173	0.000007658492320251173	+1	ARID1A,RB1,CTNNB1,AR,BRCA1,EP300,NCOR1
GO:0033143	regulation of intracellular steroid hormone receptor signaling pathway	0.000007658492320251173	0.000007658492320251173	+1	RUNX1,CRIPAK,BRCA1,FOXA1,EP300,CBFB,NCOR1
GO:0051568	histone H3-K4 methylation	0.000007762636276927137	0.000007762636276927137	+1	CTNNB1,KDM6A,TET2,BRCA1,HIST1H1C,SMAD4
GO:2000677	regulation of transcription regulatory region DNA binding	0.000007762636276927137	0.000007762636276927137	+1	GATA3,RB1,CTNNB1,TAF1,SIN3A,NSD1
GO:0042023	DNA endoreduplication	0.000007825532234760947	0.000007825532234760947	+1	FBXW7,STAG2,SMC1A,SMC3
GO:0002009	morphogenesis of an epithelium	0.000008496313159516615	0.000008496313159516615	+1	PTEN,GATA3,NOTCH1,CTNNB1,ARHGAP35,SOX9,WT1,HGF,MTOR,FGFR2,TGFBR2,SOX17
GO:0031329	regulation of cellular catabolic process	0.000008501760976777796	0.000008501760976777796	+1	PIK3CA,PTEN,CDKN2A,FBXW7,KEAP1,NFE2L2,NPM1,IDH1,STK11,CEBPA,AKT1,ATM,HGF,MTOR,LRRK2,EP300,TAF1,RPL5,AXIN2
GO:0051983	regulation of chromosome segregation	0.000008606371474446952	0.000008606371474446952	+1	APC,RB1,CTNNB1,CTCF,ATM,ATRX,AXIN2,RAD21
GO:0034097	response to cytokine	0.000008693597095528992	0.000008693597095528992	+1	TP53,PIK3CA,PIK3R1,GATA3,FLT3,NFE2L2,RUNX1,CEBPA,AKT1,SOX9,HGF,TLR4,BRCA1,KIT,SETD2,CCND1,SMAD4,FOXA2,CDKN1A,CBFB,PTPN11,LIFR
GO:0045930	negative regulation of mitotic cell cycle	0.000008755539878124053	0.000008755539878124053	+1	TP53,PTEN,APC,RB1,CTNNB1,ATM,CDKN1B,ATRX,CHEK2,EP300,CCND1,CDKN1A
GO:0042176	regulation of protein catabolic process	0.00000882503759900092	0.00000882503759900092	+1	PTEN,APC,EGFR,CDKN2A,FBXW7,KEAP1,NFE2L2,CEBPA,CDKN1B,LRRK2,CHEK2,TAF1,RPL5
GO:0071496	cellular response to external stimulus	0.000009299829986527742	0.000009299829986527742	+1	TP53,MAP3K1,ARHGAP35,MAP2K4,SOX9,MTOR,TLR4,LRRK2,FOXA2,CDKN1A,TAF1
GO:0060429	epithelium development	0.000009664046152342747	0.000009664046152342747	+1	PTEN,GATA3,NOTCH1,CTNNB1,ARHGAP35,RUNX1,AKT1,EPPK1,SOX9,WT1,HGF,ERBB4,MTOR,ELF3,FGFR2,BRCA2,TGFBR2,SOX17,CBFB,VEZF1,ERCC2
GO:0051129	negative regulation of cellular component organization	0.000010164619148399359	0.000010164619148399359	+1	PTEN,APC,NAV3,NOTCH1,NPM1,EPHA3,AKT1,AR,ATM,HGF,ATRX,BRCA1,LRRK2,HIST1H1C,EP300,SMAD4,SIN3A
GO:2000104	negative regulation of DNA-dependent DNA replication	0.000010637892780913328	0.000010637892780913328	+1	FBXW7,STAG2,CHEK2,SMC1A,SMC3
GO:0065008	regulation of biological quality	0.000010901816910850185	0.000010901816910850185	+1	TP53,PIK3CA,PTEN,APC,VHL,KRAS,NF1,PIK3R1,CDKN2A,GATA3,RB1,NOTCH1,FBXW7,FLT3,TSHZ3,KEAP1,ARHGAP35,NFE2L2,NPM1,TBX3,STK11,CEBPA,AKT1,PIK3CG,SOX9,ATM,ERBB4,MTOR,TLR4,ATRX,LRRK2,CHEK2,KIT,PDGFRA,EP300,SMAD4,FOXA2,USP9X,SOX17,CDKN1A,TAF1,ATR,PTPN11,ACVR1B,ACVR2A,RPL5,AXIN2
GO:0043405	regulation of MAP kinase activity	0.000010943452625579912	0.000010943452625579912	+1	EGFR,NF1,FLT3,MAP2K4,PIK3CG,TLR4,LRRK2,KIT,PPP2R1A,CDK12,MAPK8IP1,EZH2
GO:0006352	DNA-templated transcription, initiation	0.000010985677720863066	0.000010985677720863066	+1	TP53,PTEN,NOTCH1,CTNNB1,AR,SOX9,CCND1,CDKN1A,TAF1,CBFB,ERCC2
GO:0034644	cellular response to UV	0.000011048839408876817	0.000011048839408876817	+1	TP53,NPM1,STK11,EP300,CDKN1A,TAF1,ATR
GO:0000077	DNA damage checkpoint	0.00001108569531506266	0.00001108569531506266	+1	TP53,ATM,CDKN1B,BRCA1,CHEK2,EP300,CCND1,CDKN1A,ATR
GO:0016477	cell migration	0.000011544433799481191	0.000011544433799481191	+1	PIK3CA,PTEN,APC,NAV3,EGFR,NF1,PIK3R1,GATA3,NOTCH1,CDH1,ARHGAP35,EPHA3,AKT1,EPPK1,PIK3CG,SOX9,ATM,HGF,ERBB4,MTOR,LRRK2,KIT,PDGFRA,USP9X,PTPN11,ACVR1B,EGR3
GO:0009611	response to wounding	0.000011723440219603396	0.000011723440219603396	+1	PIK3CA,PTEN,NF1,PIK3R1,GATA3,ARHGAP35,EPPK1,PIK3CG,CDKN1B,ERBB4,MTOR,TLR4,PDGFRA,FOXA2,CDKN1A,PTPN11
GO:1903706	regulation of hemopoiesis	0.0000117977851952673	0.0000117977851952673	+1	CDKN2A,GATA3,NOTCH1,FBXW7,RUNX1,MTOR,TLR4,EP300,TGFBR2,CBFB,SIN3A,ACVR1B,ACVR2A
GO:0001763	morphogenesis of a branching structure	0.000012039100916993284	0.000012039100916993284	+1	CTNNB1,SOX9,WT1,HGF,LRRK2,FGFR2,TGFBR2
GO:1901991	negative regulation of mitotic cell cycle phase transition	0.000013626168700233046	0.000013626168700233046	+1	TP53,PTEN,APC,RB1,ATM,CDKN1B,CHEK2,EP300,CCND1,CDKN1A
GO:0006367	transcription initiation from RNA polymerase II promoter	0.000013626168700233046	0.000013626168700233046	+1	TP53,PTEN,NOTCH1,AR,SOX9,CCND1,CDKN1A,TAF1,CBFB,ERCC2
GO:0006338	chromatin remodeling	0.000014727262532278807	0.000014727262532278807	+1	ARID1A,PBRM1,CDKN2A,RB1,NPM1,KDM6A,SOX9,ATRX,FOXA1
GO:2001252	positive regulation of chromosome organization	0.000014727262532278807	0.000014727262532278807	+1	RB1,CTNNB1,ATM,ATRX,BRCA1,SMAD4,ATR,SIN3A,RAD21
GO:0071156	regulation of cell cycle arrest	0.000015019696621523888	0.000015019696621523888	+1	TP53,ATM,CDKN1B,BRCA1,CHEK2,EP300,CCND1,CDKN1A
GO:0097193	intrinsic apoptotic signaling pathway	0.000015165610432328677	0.000015165610432328677	+1	TP53,FBXW7,NFE2L2,STK11,AKT1,ATM,BRCA1,LRRK2,CHEK2,EP300,CDKN1A
GO:0072401	signal transduction involved in DNA integrity checkpoint	0.00001572439845834831	0.00001572439845834831	+1	TP53,ATM,CDKN1B,BRCA1,CHEK2,EP300,CDKN1A
GO:0072422	signal transduction involved in DNA damage checkpoint	0.00001572439845834831	0.00001572439845834831	+1	TP53,ATM,CDKN1B,BRCA1,CHEK2,EP300,CDKN1A
GO:0090329	regulation of DNA-dependent DNA replication	0.00001652834717296776	0.00001652834717296776	+1	FBXW7,STAG2,ATRX,CHEK2,SMC1A,SMC3
GO:0016579	protein deubiquitination	0.000016663727194919843	0.000016663727194919843	+1	TP53,PTEN,APC,GATA3,KEAP1,BAP1,AR,BRCA1,SMAD4,USP9X,ASXL1,SMAD2
GO:0072395	signal transduction involved in cell cycle checkpoint	0.000017125330843674254	0.000017125330843674254	+1	TP53,ATM,CDKN1B,BRCA1,CHEK2,EP300,CDKN1A
GO:0031497	chromatin assembly	0.000017223845723002905	0.000017223845723002905	+1	TP53,CDKN2A,CTCF,NPM1,SOX9,ATRX,HIST1H1C,HIST1H2BD,H3F3C
GO:0051091	positive regulation of DNA-binding transcription factor activity	0.000017683014390908343	0.000017683014390908343	+1	PTEN,CTNNB1,NPM1,AKT1,AR,TLR4,ARID5B,FOXA1,KIT,EP300,TAF1
GO:0007155	cell adhesion	0.000017745601752015103	0.000017745601752015103	+1	PIK3CA,PTEN,APC,EGFR,NF1,PIK3R1,CDKN2A,GATA3,NOTCH1,CTNNB1,CDH1,RUNX1,EPHA3,AKT1,PIK3CG,ATM,FOXA1,KIT,PDGFRA,FOXA2,TGFBR2,PPP2R1A,CBFB,PTPN11
GO:0043550	regulation of lipid kinase activity	0.000018487778061340272	0.000018487778061340272	+1	PIK3R1,RB1,FLT3,KIT,PDGFRA,FGFR3
GO:0061180	mammary gland epithelium development	0.000018544129416942156	0.000018544129416942156	+1	GATA3,AKT1,ERBB4,FGFR2,BRCA2
GO:0070602	regulation of centromeric sister chromatid cohesion	0.000018544129416942156	0.000018544129416942156	+1	CTNNB1,CTCF,AXIN2
GO:2000045	regulation of G1/S transition of mitotic cell cycle	0.000019047076563536905	0.000019047076563536905	+1	TP53,PTEN,RB1,ATM,CDKN1B,CHEK2,EP300,CCND1,CDKN1A
GO:0071901	negative regulation of protein serine/threonine kinase activity	0.00001930915431247508	0.00001930915431247508	+1	APC,NF1,CDKN2A,CEBPA,AKT1,CDKN1B,PPP2R1A,MAPK8IP1
GO:0043933	protein-containing complex subunit organization	0.00001954909984621751	0.00001954909984621751	+1	TP53,APC,ARID1A,PBRM1,NAV3,NF1,RB1,CTNNB1,CTCF,NPM1,AR,AJUBA,SOX9,ATM,TLR4,ATRX,LRRK2,POLQ,HIST1H1C,SETD2,EP300,SMAD4,SF3B1,TAF1,PPP2R1A,ATR,HIST1H2BD,PTPN11,H3F3C,RPL5,SMAD2,AXIN2,ERCC2
GO:0022610	biological adhesion	0.00001956685779716399	0.00001956685779716399	+1	PIK3CA,PTEN,APC,EGFR,NF1,PIK3R1,CDKN2A,GATA3,NOTCH1,CTNNB1,CDH1,RUNX1,EPHA3,AKT1,PIK3CG,ATM,FOXA1,KIT,PDGFRA,FOXA2,TGFBR2,PPP2R1A,CBFB,PTPN11
GO:0033365	protein localization to organelle	0.00002101316846367531	0.00002101316846367531	+1	TP53,APC,PIK3R1,RB1,FBXW7,CDH1,CTCF,BAP1,IDH1,AKT1,ATM,ATRX,LRRK2,SETD2,USP9X,BRCA2,ATR,SIN3A,RPL5,RAD21
GO:0031570	DNA integrity checkpoint	0.00002108167296917546	0.00002108167296917546	+1	TP53,ATM,CDKN1B,BRCA1,CHEK2,EP300,CCND1,CDKN1A,ATR
GO:0022612	gland morphogenesis	0.000022050288687541643	0.000022050288687541643	+1	FBXW7,SOX9,HGF,ELF3,FGFR2
GO:0072001	renal system development	0.00002219278831285694	0.00002219278831285694	+1	NF1,GATA3,CTNNB1,SOX9,WT1,LRRK2,PDGFRA,FGFR2,SOX17
GO:0030520	intracellular estrogen receptor signaling pathway	0.000023004395745322128	0.000023004395745322128	+1	ARID1A,RUNX1,CRIPAK,BRCA1,FOXA1,CBFB
GO:2000060	positive regulation of ubiquitin-dependent protein catabolic process	0.000023493654978103584	0.000023493654978103584	+1	PTEN,FBXW7,KEAP1,NFE2L2,CEBPA,LRRK2,TAF1
GO:0071158	positive regulation of cell cycle arrest	0.000023493654978103584	0.000023493654978103584	+1	TP53,ATM,CDKN1B,BRCA1,CHEK2,EP300,CDKN1A
GO:0048598	embryonic morphogenesis	0.000024710991355501263	0.000024710991355501263	+1	GATA3,NOTCH1,CTNNB1,TBX3,SOX9,SETD2,PDGFRA,FGFR2,FOXA2,TGFBR2,SOX17,SMAD2
GO:0048699	generation of neurons	0.000025487221558989798	0.000025487221558989798	+1	PIK3CA,PTEN,NF1,PIK3R1,RB1,NOTCH1,CTNNB1,ARHGAP35,RUNX1,EPHA3,AKT1,SOX9,ERBB4,LRRK2,FOXA1,EP300,FGFR2,FOXA2,USP9X,PTPN11,MIR142,ERCC2
GO:0048589	developmental growth	0.000025487221558989798	0.000025487221558989798	+1	PTEN,NOTCH1,CTNNB1,EPPK1,SOX9,CDKN1B,WT1,ERBB4,FGFR2,USP9X,FGFR3,CDKN1A
GO:0110110	positive regulation of animal organ morphogenesis	0.000025533170729728218	0.000025533170729728218	+1	GATA3,NOTCH1,SOX9,WT1,FGFR2,TGFBR2
GO:0043276	anoikis	0.000025844717567205527	0.000025844717567205527	+1	PIK3CA,NOTCH1,STK11,AKT1,MTOR
GO:0009880	embryonic pattern specification	0.000025844717567205527	0.000025844717567205527	+1	TBX3,WT1,ERBB4,FGFR2,SMAD2
GO:1901990	regulation of mitotic cell cycle phase transition	0.000026626302603390918	0.000026626302603390918	+1	TP53,PTEN,APC,CDKN2A,RB1,ATM,CDKN1B,CHEK2,EP300,CCND1,CDKN1A,PPP2R1A,ERCC2
GO:0050865	regulation of cell activation	0.00002823497798391293	0.00002823497798391293	+1	PIK3CA,PIK3R1,CDKN2A,GATA3,RUNX1,CEBPA,AKT1,ATM,TLR4,PDGFRA,TGFBR2,CBFB,PTPN11,MAPK8IP1,MIR142
GO:0071478	cellular response to radiation	0.000028382397460298388	0.000028382397460298388	+1	TP53,GATA3,NPM1,STK11,ATM,EP300,CDKN1A,TAF1,ATR
GO:0070646	protein modification by small protein removal	0.000028876370798010056	0.000028876370798010056	+1	TP53,PTEN,APC,GATA3,KEAP1,BAP1,AR,BRCA1,SMAD4,USP9X,ASXL1,SMAD2
GO:0022409	positive regulation of cell-cell adhesion	0.000029534973751018965	0.000029534973751018965	+1	PIK3CA,PIK3R1,GATA3,RUNX1,AKT1,FOXA1,FOXA2,TGFBR2,CBFB,PTPN11
GO:1901698	response to nitrogen compound	0.000029934561530790736	0.000029934561530790736	+1	TP53,PIK3CA,APC,PIK3R1,CTNNB1,CDH1,NFE2L2,NPM1,AKT1,SOX9,WT1,MTOR,TLR4,ATRX,BRCA1,LRRK2,TAF1,PTPN11
GO:0044839	cell cycle G2/M phase transition	0.00003365257297138533	0.00003365257297138533	+1	TP53,CDKN2A,NPM1,AJUBA,ATM,BRCA1,CHEK2,CCND1,CDKN1A,PPP2R1A
GO:0061041	regulation of wound healing	0.00003558992340374892	0.00003558992340374892	+1	PTEN,EPPK1,CDKN1B,MTOR,TLR4,PDGFRA,FOXA2,CDKN1A
GO:0007093	mitotic cell cycle checkpoint	0.000036467716215254355	0.000036467716215254355	+1	TP53,APC,RB1,ATM,CDKN1B,CHEK2,EP300,CCND1,CDKN1A
GO:0071345	cellular response to cytokine stimulus	0.000036738767461370706	0.000036738767461370706	+1	TP53,PIK3CA,PIK3R1,GATA3,FLT3,NFE2L2,RUNX1,CEBPA,AKT1,SOX9,HGF,TLR4,BRCA1,KIT,CCND1,SMAD4,CDKN1A,CBFB,PTPN11,LIFR
GO:0090100	positive regulation of transmembrane receptor protein serine/threonine kinase signaling pathway	0.00003722554286718397	0.00003722554286718397	+1	NOTCH1,STK11,EP300,SMAD4,ACVR1B,ACVR2A,SMAD2
GO:0070507	regulation of microtubule cytoskeleton organization	0.00003813830150418684	0.00003813830150418684	+1	APC,NAV3,CTNNB1,NPM1,EPHA3,STAG2,BRCA1,SMC1A,SMC3
GO:2000736	regulation of stem cell differentiation	0.000038678850633799873	0.000038678850633799873	+1	GATA3,NOTCH1,RUNX1,SOX9,PDGFRA,CBFB
GO:0060828	regulation of canonical Wnt signaling pathway	0.00003950335216213973	0.00003950335216213973	+1	APC,EGFR,CTNNB1,STK11,SOX9,LRRK2,FGFR2,SOX17,TBL1XR1,AXIN2
GO:0048511	rhythmic process	0.000039872419814553686	0.000039872419814553686	+1	TP53,PTEN,PDGFRA,EP300,USP9X,SIN3A,EGR3,NCOR1,EZH2
GO:0098609	cell-cell adhesion	0.00004061804581046184	0.00004061804581046184	+1	PIK3CA,EGFR,PIK3R1,CDKN2A,GATA3,CTNNB1,CDH1,RUNX1,AKT1,PIK3CG,FOXA1,KIT,PDGFRA,FOXA2,TGFBR2,CBFB,PTPN11
GO:0010639	negative regulation of organelle organization	0.00004086730703708829	0.00004086730703708829	+1	APC,NAV3,NPM1,AKT1,ATM,HGF,ATRX,BRCA1,LRRK2,HIST1H1C,SMAD4,SIN3A
GO:0033146	regulation of intracellular estrogen receptor signaling pathway	0.000041239528249065356	0.000041239528249065356	+1	RUNX1,CRIPAK,BRCA1,FOXA1,CBFB
GO:0007169	transmembrane receptor protein tyrosine kinase signaling pathway	0.00004202738005372384	0.00004202738005372384	+1	PIK3CA,APC,EGFR,PIK3R1,GATA3,FBXW7,FLT3,EPHA3,AKT1,SOX9,HGF,ERBB4,KIT,PDGFRA,FGFR2,FGFR3,PTPN11
GO:0071681	cellular response to indole-3-methanol	0.00004202738005372384	0.00004202738005372384	+1	CTNNB1,CDH1,BRCA1
GO:0071680	response to indole-3-methanol	0.00004202738005372384	0.00004202738005372384	+1	CTNNB1,CDH1,BRCA1
GO:0003151	outflow tract morphogenesis	0.000042069715649366644	0.000042069715649366644	+1	NOTCH1,CTNNB1,FGFR2,SMAD4,TGFBR2,SOX17
GO:0006977	DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest	0.000042069715649366644	0.000042069715649366644	+1	TP53,ATM,CDKN1B,CHEK2,EP300,CDKN1A
GO:0043085	positive regulation of catalytic activity	0.0000433358732252205	0.0000433358732252205	+1	PTEN,EGFR,NF1,CDKN2A,FBXW7,MAP3K1,FLT3,MAP2K4,STK11,AKT1,PIK3CG,MTOR,TLR4,LRRK2,KIT,PDGFRA,FGFR2,CCND1,FGFR3,TGFBR2,CDKN1A,EZH2
GO:0022407	regulation of cell-cell adhesion	0.0000458481987263433	0.0000458481987263433	+1	PIK3CA,PIK3R1,CDKN2A,GATA3,CDH1,RUNX1,AKT1,FOXA1,FOXA2,TGFBR2,CBFB,PTPN11
GO:1903201	regulation of oxidative stress-induced cell death	0.00004609507479930378	0.00004609507479930378	+1	FBXW7,NFE2L2,AKT1,HGF,TLR4,LRRK2
GO:1902400	intracellular signal transduction involved in G1 DNA damage checkpoint	0.00004609507479930378	0.00004609507479930378	+1	TP53,ATM,CDKN1B,CHEK2,EP300,CDKN1A
GO:0072431	signal transduction involved in mitotic G1 DNA damage checkpoint	0.00004609507479930378	0.00004609507479930378	+1	TP53,ATM,CDKN1B,CHEK2,EP300,CDKN1A
GO:0050678	regulation of epithelial cell proliferation	0.00004609507479930378	0.00004609507479930378	+1	EGFR,NF1,GATA3,FBXW7,NRAS,AKT1,EPPK1,SOX9,FGFR2,BRCA2,EGR3
GO:0009605	response to external stimulus	0.000046331586537512746	0.000046331586537512746	+1	TP53,PIK3CA,PTEN,KRAS,PIK3R1,GATA3,RB1,NOTCH1,MAP3K1,ARHGAP35,NRAS,MAP2K4,CEBPA,EPHA3,EPPK1,PIK3CG,SOX9,CDKN1B,HGF,MTOR,TLR4,LRRK2,KIT,SETD2,PDGFRA,EP300,FOXA2,CDKN1A,TAF1,SIN3A,PTPN11,EGR3,MIR142
GO:0022008	neurogenesis	0.00005111643598560558	0.00005111643598560558	+1	PIK3CA,PTEN,NF1,PIK3R1,RB1,NOTCH1,CTNNB1,ARHGAP35,RUNX1,EPHA3,AKT1,SOX9,ERBB4,LRRK2,FOXA1,EP300,FGFR2,FOXA2,USP9X,PTPN11,MIR142,ERCC2
GO:0007399	nervous system development	0.00005362037364159214	0.00005362037364159214	+1	PIK3CA,PTEN,NAV3,NF1,PIK3R1,GATA3,RB1,NOTCH1,CTNNB1,CDH1,ARHGAP35,RUNX1,EPHA3,AKT1,SOX9,PRX,ERBB4,LRRK2,FOXA1,EP300,FGFR2,FOXA2,USP9X,TGFBR2,TAF1,PTPN11,MIR142,ERCC2
GO:0002694	regulation of leukocyte activation	0.000054576888064857804	0.000054576888064857804	+1	PIK3CA,PIK3R1,CDKN2A,GATA3,RUNX1,CEBPA,AKT1,ATM,TLR4,TGFBR2,CBFB,PTPN11,MAPK8IP1,MIR142
GO:1902403	signal transduction involved in mitotic DNA integrity checkpoint	0.00005564390258573336	0.00005564390258573336	+1	TP53,ATM,CDKN1B,CHEK2,EP300,CDKN1A
GO:1902402	signal transduction involved in mitotic DNA damage checkpoint	0.00005564390258573336	0.00005564390258573336	+1	TP53,ATM,CDKN1B,CHEK2,EP300,CDKN1A
GO:0072413	signal transduction involved in mitotic cell cycle checkpoint	0.00005564390258573336	0.00005564390258573336	+1	TP53,ATM,CDKN1B,CHEK2,EP300,CDKN1A
GO:0051130	positive regulation of cellular component organization	0.0000568259148619345	0.0000568259148619345	+1	TP53,APC,NAV3,RB1,FBXW7,CTNNB1,ARHGAP35,BAP1,EPHA3,AR,AJUBA,ATM,TLR4,ATRX,BRCA1,EP300,SMAD4,ATR,SIN3A,RAD21,ERCC2
GO:0048870	cell motility	0.000059509891967220356	0.000059509891967220356	+1	PIK3CA,PTEN,APC,NAV3,EGFR,NF1,PIK3R1,GATA3,NOTCH1,CDH1,ARHGAP35,EPHA3,AKT1,EPPK1,PIK3CG,SOX9,ATM,HGF,ERBB4,MTOR,LRRK2,KIT,PDGFRA,USP9X,PTPN11,ACVR1B,EGR3
GO:0051674	localization of cell	0.000059509891967220356	0.000059509891967220356	+1	PIK3CA,PTEN,APC,NAV3,EGFR,NF1,PIK3R1,GATA3,NOTCH1,CDH1,ARHGAP35,EPHA3,AKT1,EPPK1,PIK3CG,SOX9,ATM,HGF,ERBB4,MTOR,LRRK2,KIT,PDGFRA,USP9X,PTPN11,ACVR1B,EGR3
GO:0010212	response to ionizing radiation	0.00005958011188602897	0.00005958011188602897	+1	TP53,GATA3,STK11,ATM,BRCA1,CDKN1A,ATR
GO:0001944	vasculature development	0.000060120812046875306	0.000060120812046875306	+1	PIK3CA,NF1,NOTCH1,FBXW7,CTNNB1,RUNX1,STK11,AKT1,WT1,BRCA1,KIT,PDGFRA,FGFR2,TGFBR2,SOX17,EGR3
GO:0002682	regulation of immune system process	0.00006241543120914796	0.00006241543120914796	+1	PIK3CA,KRAS,PIK3R1,CDKN2A,GATA3,NOTCH1,FBXW7,MAP3K1,RUNX1,NRAS,CEBPA,AKT1,SOX9,ATM,MTOR,TLR4,KIT,EP300,TGFBR2,CBFB,SIN3A,PTPN11,ACVR1B,MAPK8IP1,ACVR2A,MIR142
GO:0006261	DNA-dependent DNA replication	0.00006373527182002879	0.00006373527182002879	+1	FBXW7,STAG2,ATRX,POLQ,CHEK2,BRCA2,SMC1A,SMC3
GO:0060341	regulation of cellular localization	0.00006373527182002879	0.00006373527182002879	+1	TP53,PTEN,APC,EGFR,PIK3R1,RB1,FBXW7,CTNNB1,CDH1,BAP1,EPHA3,AKT1,AR,LRRK2,SETD2,FOXA2,SIN3A
GO:0072358	cardiovascular system development	0.00006373724136535842	0.00006373724136535842	+1	PIK3CA,NF1,NOTCH1,FBXW7,CTNNB1,RUNX1,STK11,AKT1,WT1,BRCA1,KIT,PDGFRA,FGFR2,TGFBR2,SOX17,EGR3
GO:1902532	negative regulation of intracellular signal transduction	0.00006530966633075775	0.00006530966633075775	+1	PTEN,NF1,NFE2L2,STK11,AKT1,AJUBA,ATM,TLR4,LRRK2,SMAD4,PPP2R1A,MAPK8IP1,MECOM,NCOR1
GO:0051493	regulation of cytoskeleton organization	0.00006530966633075775	0.00006530966633075775	+1	APC,NAV3,CTNNB1,ARHGAP35,NPM1,CRIPAK,EPHA3,STAG2,MTOR,BRCA1,PDGFRA,SMAD4,SMC1A,SMC3
GO:0001667	ameboidal-type cell migration	0.00006651721906377497	0.00006651721906377497	+1	PIK3CA,PTEN,NF1,GATA3,NOTCH1,AKT1,EPPK1,SOX9,ERBB4,MTOR,KIT,ACVR1B,EGR3
GO:0042110	T cell activation	0.00006822615987240875	0.00006822615987240875	+1	PIK3CA,PIK3R1,CDKN2A,GATA3,RUNX1,AKT1,PIK3CG,KIT,TGFBR2,CBFB,PTPN11,MAPK8IP1
GO:1903050	regulation of proteolysis involved in cellular protein catabolic process	0.00006971295521675362	0.00006971295521675362	+1	PTEN,CDKN2A,FBXW7,KEAP1,NFE2L2,CEBPA,LRRK2,TAF1,RPL5
GO:0038127	ERBB signaling pathway	0.00007029956880455345	0.00007029956880455345	+1	PIK3CA,EGFR,PIK3R1,FBXW7,AKT1,SOX9,ERBB4,PTPN11
GO:0035690	cellular response to drug	0.00007080089327256612	0.00007080089327256612	+1	TP53,CTNNB1,CDH1,NFE2L2,SOX9,HGF,ATRX,BRCA1,LRRK2,TAF1
GO:0044773	mitotic DNA damage checkpoint	0.00007172158373751164	0.00007172158373751164	+1	TP53,ATM,CDKN1B,CHEK2,EP300,CCND1,CDKN1A
GO:0061138	morphogenesis of a branching epithelium	0.00007172158373751164	0.00007172158373751164	+1	CTNNB1,SOX9,WT1,HGF,FGFR2,TGFBR2
GO:0048638	regulation of developmental growth	0.00007226851888259246	0.00007226851888259246	+1	PTEN,NOTCH1,EPPK1,CDKN1B,WT1,ERBB4,FGFR2,FGFR3,CDKN1A
GO:1903034	regulation of response to wounding	0.00007356966969951131	0.00007356966969951131	+1	PTEN,EPPK1,CDKN1B,MTOR,TLR4,PDGFRA,FOXA2,CDKN1A
GO:0032927	positive regulation of activin receptor signaling pathway	0.00007706857870117185	0.00007706857870117185	+1	ACVR1B,ACVR2A,SMAD2
GO:0070141	response to UV-A	0.00007706857870117185	0.00007706857870117185	+1	EGFR,AKT1,CCND1
GO:0003281	ventricular septum development	0.00007909420658457005	0.00007909420658457005	+1	GATA3,NOTCH1,FGFR2,SMAD4,TGFBR2
GO:1903052	positive regulation of proteolysis involved in cellular protein catabolic process	0.00008136155066854528	0.00008136155066854528	+1	PTEN,FBXW7,KEAP1,NFE2L2,CEBPA,LRRK2,TAF1
GO:0071103	DNA conformation change	0.00008136155066854528	0.00008136155066854528	+1	TP53,CDKN2A,CTCF,NPM1,SOX9,ATRX,HIST1H1C,HIST1H2BD,H3F3C,ERCC2
GO:0001666	response to hypoxia	0.0000817584342881046	0.0000817584342881046	+1	TP53,VHL,NF1,NOTCH1,NFE2L2,AJUBA,MTOR,EP300,SMAD4
GO:0045736	negative regulation of cyclin-dependent protein serine/threonine kinase activity	0.00008242110810984527	0.00008242110810984527	+1	APC,CDKN2A,CEBPA,CDKN1B
GO:1900407	regulation of cellular response to oxidative stress	0.00008449574954129205	0.00008449574954129205	+1	FBXW7,NFE2L2,AKT1,HGF,TLR4,LRRK2
GO:0010243	response to organonitrogen compound	0.0000924601161991845	0.0000924601161991845	+1	TP53,PIK3CA,APC,PIK3R1,CTNNB1,CDH1,NFE2L2,AKT1,SOX9,WT1,MTOR,TLR4,BRCA1,LRRK2,TAF1,PTPN11
GO:0036293	response to decreased oxygen levels	0.00009264539792910355	0.00009264539792910355	+1	TP53,VHL,NF1,NOTCH1,NFE2L2,AJUBA,MTOR,EP300,SMAD4
GO:0006323	DNA packaging	0.00009264539792910355	0.00009264539792910355	+1	TP53,CDKN2A,CTCF,NPM1,SOX9,ATRX,HIST1H1C,HIST1H2BD,H3F3C
GO:0001822	kidney development	0.00009430428217434828	0.00009430428217434828	+1	NF1,GATA3,CTNNB1,SOX9,WT1,LRRK2,PDGFRA,FGFR2
GO:0050673	epithelial cell proliferation	0.0000979702759441874	0.0000979702759441874	+1	EGFR,NF1,GATA3,FBXW7,NRAS,AKT1,EPPK1,SOX9,FGFR2,BRCA2,EGR3
GO:1903725	regulation of phospholipid metabolic process	0.00009986974874241368	0.00009986974874241368	+1	PIK3R1,FLT3,IDH1,KIT,PDGFRA,FGFR3
GO:0002521	leukocyte differentiation	0.00010285828407301755	0.00010285828407301755	+1	CDKN2A,GATA3,FBXW7,FLT3,RUNX1,CEBPA,ATM,MTOR,TLR4,KIT,TGFBR2,CBFB
GO:0045732	positive regulation of protein catabolic process	0.00010471900168606341	0.00010471900168606341	+1	PTEN,APC,FBXW7,KEAP1,NFE2L2,CEBPA,CDKN1B,LRRK2,TAF1
GO:0040012	regulation of locomotion	0.00010582318024836702	0.00010582318024836702	+1	PTEN,APC,NAV3,EGFR,NF1,GATA3,NOTCH1,CDH1,AKT1,EPPK1,SOX9,ATM,HGF,ERBB4,MTOR,LRRK2,KIT,PDGFRA,ACVR1B,SMC3
GO:0050863	regulation of T cell activation	0.00010758695774550176	0.00010758695774550176	+1	PIK3CA,PIK3R1,CDKN2A,GATA3,RUNX1,AKT1,TGFBR2,CBFB,PTPN11,MAPK8IP1
GO:0031060	regulation of histone methylation	0.00011316177557983017	0.00011316177557983017	+1	CTNNB1,ATRX,BRCA1,SMAD4,NSD1
GO:0043551	regulation of phosphatidylinositol 3-kinase activity	0.00011316177557983017	0.00011316177557983017	+1	PIK3R1,FLT3,KIT,PDGFRA,FGFR3
GO:0045165	cell fate commitment	0.00011428438115102453	0.00011428438115102453	+1	APC,GATA3,SOX9,WT1,FGFR2,FOXA2,SOX17,SMAD2
GO:0032886	regulation of microtubule-based process	0.00011784091703212719	0.00011784091703212719	+1	APC,NAV3,CTNNB1,NPM1,EPHA3,STAG2,BRCA1,SMC1A,SMC3
GO:0007623	circadian rhythm	0.00011984665822723576	0.00011984665822723576	+1	TP53,PTEN,EP300,USP9X,SIN3A,EGR3,NCOR1,EZH2
GO:0044774	mitotic DNA integrity checkpoint	0.00012423198184005035	0.00012423198184005035	+1	TP53,ATM,CDKN1B,CHEK2,EP300,CCND1,CDKN1A
GO:0009895	negative regulation of catabolic process	0.0001276380732655155	0.0001276380732655155	+1	PIK3CA,EGFR,CDKN2A,AKT1,HGF,MTOR,LRRK2,TAF1,RPL5,AXIN2
GO:0061026	cardiac muscle tissue regeneration	0.00012765675874535395	0.00012765675874535395	+1	CDKN1B,ERBB4,CDKN1A
GO:0035265	organ growth	0.0001315568903365869	0.0001315568903365869	+1	PTEN,NOTCH1,SOX9,WT1,ERBB4,FGFR2,FGFR3
GO:0018105	peptidyl-serine phosphorylation	0.0001315835781563646	0.0001315835781563646	+1	EGFR,AKT1,BRAF,ATM,MTOR,LRRK2,TGFBR2,TAF1,ATR,NSD1
GO:1903320	regulation of protein modification by small protein conjugation or removal	0.00013203903249547097	0.00013203903249547097	+1	PTEN,CDKN2A,FBXW7,CTNNB1,AKT1,BRCA1,LRRK2,TAF1,RPL5
GO:0019827	stem cell population maintenance	0.00013579443624188496	0.00013579443624188496	+1	NOTCH1,CTNNB1,SOX9,KIT,SMAD4,SMAD2
GO:1902882	regulation of response to oxidative stress	0.00013579443624188496	0.00013579443624188496	+1	FBXW7,NFE2L2,AKT1,HGF,TLR4,LRRK2
GO:0050730	regulation of peptidyl-tyrosine phosphorylation	0.00013652250877195648	0.00013652250877195648	+1	TP53,EGFR,FBXW7,FLT3,HGF,ERBB4,KIT,FGFR3,PPP2R1A
GO:0045637	regulation of myeloid cell differentiation	0.00013652250877195648	0.00013652250877195648	+1	FBXW7,RUNX1,MTOR,TLR4,EP300,CBFB,SIN3A,ACVR1B,ACVR2A
GO:0043409	negative regulation of MAPK cascade	0.00013652250877195648	0.00013652250877195648	+1	PTEN,NF1,TLR4,SMAD4,PPP2R1A,MAPK8IP1,MECOM,NCOR1
GO:0046660	female sex differentiation	0.00014023147391346372	0.00014023147391346372	+1	TBX3,WT1,KIT,PDGFRA,BRCA2
GO:0070482	response to oxygen levels	0.00014161793952184557	0.00014161793952184557	+1	TP53,VHL,NF1,NOTCH1,NFE2L2,AJUBA,MTOR,EP300,SMAD4
GO:0043618	regulation of transcription from RNA polymerase II promoter in response to stress	0.00014537924560922315	0.00014537924560922315	+1	TP53,VHL,NOTCH1,NFE2L2,EP300,TAF1
GO:0098727	maintenance of cell number	0.00014537924560922315	0.00014537924560922315	+1	NOTCH1,CTNNB1,SOX9,KIT,SMAD4,SMAD2
GO:0032880	regulation of protein localization	0.00014540283757299502	0.00014540283757299502	+1	TP53,APC,EGFR,PIK3R1,GATA3,RB1,FBXW7,CTNNB1,CDH1,BAP1,EPHA3,AKT1,AR,TLR4,LRRK2,SETD2,FOXA2,SIN3A
GO:0040011	locomotion	0.00014633277672778606	0.00014633277672778606	+1	PIK3CA,PTEN,APC,NAV3,EGFR,NF1,PIK3R1,GATA3,NOTCH1,CDH1,ARHGAP35,EPHA3,AKT1,EPPK1,PIK3CG,SOX9,ATM,HGF,ERBB4,MTOR,LRRK2,KIT,PDGFRA,USP9X,PTPN11,ACVR1B,EGR3,SMC3
GO:0040029	regulation of gene expression, epigenetic	0.0001467511030508211	0.0001467511030508211	+1	TP53,ARID1A,EGFR,DNMT3A,CTCF,AJUBA,BRCA1,HIST1H1C,EP300,SF3B1,SIN3A,NCOR1,SMAD2,EZH2
GO:1901522	positive regulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus	0.00014757396959361283	0.00014757396959361283	+1	NOTCH1,NFE2L2,EP300,SMAD4
GO:0045785	positive regulation of cell adhesion	0.0001546154179260783	0.0001546154179260783	+1	PIK3CA,PIK3R1,GATA3,RUNX1,AKT1,ATM,FOXA1,FOXA2,TGFBR2,CBFB,PTPN11
GO:0036473	cell death in response to oxidative stress	0.00015547055977648496	0.00015547055977648496	+1	FBXW7,NFE2L2,AKT1,HGF,TLR4,LRRK2
GO:0072089	stem cell proliferation	0.00015547055977648496	0.00015547055977648496	+1	NF1,CTNNB1,RUNX1,LRRK2,FGFR2,MECOM
GO:0065004	protein-DNA complex assembly	0.00015720932558570022	0.00015720932558570022	+1	TP53,RB1,NPM1,SOX9,ATRX,TAF1,HIST1H2BD,H3F3C,ERCC2
GO:1902115	regulation of organelle assembly	0.00016215460518109005	0.00016215460518109005	+1	ARHGAP35,NPM1,STAG2,BRCA1,LRRK2,SMAD4,SMC1A,SMC3
GO:0071560	cellular response to transforming growth factor beta stimulus	0.0001698782270602147	0.0001698782270602147	+1	STK11,SOX9,EP300,SMAD4,USP9X,TGFBR2,ACVR1B,ACVR2A,SMAD2
GO:0007173	epidermal growth factor receptor signaling pathway	0.0001712075575464398	0.0001712075575464398	+1	PIK3CA,EGFR,PIK3R1,FBXW7,AKT1,SOX9,PTPN11
GO:0003179	heart valve morphogenesis	0.00017175741653280836	0.00017175741653280836	+1	GATA3,RB1,NOTCH1,SOX9,TGFBR2
GO:0002696	positive regulation of leukocyte activation	0.00017230907549087857	0.00017230907549087857	+1	PIK3CA,PIK3R1,GATA3,RUNX1,CEBPA,AKT1,TLR4,TGFBR2,CBFB,PTPN11,MIR142
GO:0006359	regulation of transcription by RNA polymerase III	0.00017554185209401962	0.00017554185209401962	+1	CEBPA,AR,MTOR,BRCA1
GO:0016242	negative regulation of macroautophagy	0.00017554185209401962	0.00017554185209401962	+1	PIK3CA,AKT1,MTOR,LRRK2
GO:0071482	cellular response to light stimulus	0.00017995812811680859	0.00017995812811680859	+1	TP53,NPM1,STK11,EP300,CDKN1A,TAF1,ATR
GO:0060562	epithelial tube morphogenesis	0.00018444089531065815	0.00018444089531065815	+1	GATA3,NOTCH1,CTNNB1,SOX9,WT1,FGFR2,TGFBR2,SOX17
GO:0030182	neuron differentiation	0.00019227882890200163	0.00019227882890200163	+1	PIK3CA,PTEN,PIK3R1,RB1,CTNNB1,ARHGAP35,RUNX1,EPHA3,AKT1,SOX9,ERBB4,LRRK2,FOXA1,EP300,FGFR2,FOXA2,USP9X,PTPN11,ERCC2
GO:0033002	muscle cell proliferation	0.00019227882890200163	0.00019227882890200163	+1	PTEN,NOTCH1,CTNNB1,AKT1,CDKN1B,ERBB4,FGFR2,CDKN1A
GO:0030334	regulation of cell migration	0.00019227882890200163	0.00019227882890200163	+1	PTEN,APC,NAV3,EGFR,NF1,GATA3,NOTCH1,CDH1,AKT1,EPPK1,SOX9,ATM,HGF,ERBB4,MTOR,KIT,PDGFRA,ACVR1B
GO:0031330	negative regulation of cellular catabolic process	0.00020264514949990063	0.00020264514949990063	+1	PIK3CA,CDKN2A,AKT1,HGF,MTOR,LRRK2,TAF1,RPL5,AXIN2
GO:1903362	regulation of cellular protein catabolic process	0.00020264514949990063	0.00020264514949990063	+1	PTEN,CDKN2A,FBXW7,KEAP1,NFE2L2,CEBPA,LRRK2,TAF1,RPL5
GO:0003170	heart valve development	0.00020915420089621264	0.00020915420089621264	+1	GATA3,RB1,NOTCH1,SOX9,TGFBR2
GO:0001656	metanephros development	0.00020915420089621264	0.00020915420089621264	+1	NF1,GATA3,SOX9,WT1,PDGFRA
GO:0050870	positive regulation of T cell activation	0.00020915420089621264	0.00020915420089621264	+1	PIK3CA,PIK3R1,GATA3,RUNX1,AKT1,TGFBR2,CBFB,PTPN11
GO:0022603	regulation of anatomical structure morphogenesis	0.00021246779972758804	0.00021246779972758804	+1	PTEN,NF1,GATA3,NOTCH1,FBXW7,CTNNB1,ARHGAP35,RUNX1,SOX9,WT1,HGF,MTOR,BRCA1,LRRK2,KIT,FGFR2,SMAD4,FOXA2,TGFBR2
GO:0071559	response to transforming growth factor beta	0.00021705215331569314	0.00021705215331569314	+1	STK11,SOX9,EP300,SMAD4,USP9X,TGFBR2,ACVR1B,ACVR2A,SMAD2
GO:0010631	epithelial cell migration	0.00021930526471373193	0.00021930526471373193	+1	PIK3CA,PTEN,NF1,GATA3,NOTCH1,AKT1,EPPK1,SOX9,MTOR,KIT,EGR3
GO:0043620	regulation of DNA-templated transcription in response to stress	0.00021930526471373193	0.00021930526471373193	+1	TP53,VHL,NOTCH1,NFE2L2,EP300,TAF1
GO:1903364	positive regulation of cellular protein catabolic process	0.00022015506808542189	0.00022015506808542189	+1	PTEN,FBXW7,KEAP1,NFE2L2,CEBPA,LRRK2,TAF1
GO:0071456	cellular response to hypoxia	0.00022015506808542189	0.00022015506808542189	+1	TP53,VHL,NOTCH1,NFE2L2,AJUBA,MTOR,EP300
GO:0046425	regulation of receptor signaling pathway via JAK-STAT	0.00022015506808542189	0.00022015506808542189	+1	VHL,NOTCH1,FLT3,ERBB4,KIT,FGFR3,PPP2R1A
GO:0018209	peptidyl-serine modification	0.00022666345706740383	0.00022666345706740383	+1	EGFR,AKT1,BRAF,ATM,MTOR,LRRK2,TGFBR2,TAF1,ATR,NSD1
GO:0050867	positive regulation of cell activation	0.00023003440133649914	0.00023003440133649914	+1	PIK3CA,PIK3R1,GATA3,RUNX1,CEBPA,AKT1,TLR4,TGFBR2,CBFB,PTPN11,MIR142
GO:0090132	epithelium migration	0.00023003440133649914	0.00023003440133649914	+1	PIK3CA,PTEN,NF1,GATA3,NOTCH1,AKT1,EPPK1,SOX9,MTOR,KIT,EGR3
GO:0008593	regulation of Notch signaling pathway	0.000233069327558562	0.000233069327558562	+1	EGFR,NOTCH1,FBXW7,AKT1,ELF3,EP300
GO:0065003	protein-containing complex assembly	0.0002334252726655972	0.0002334252726655972	+1	TP53,APC,NAV3,RB1,CTNNB1,NPM1,AR,AJUBA,SOX9,ATM,TLR4,ATRX,LRRK2,POLQ,EP300,SMAD4,SF3B1,TAF1,PPP2R1A,ATR,HIST1H2BD,PTPN11,H3F3C,RPL5,SMAD2,AXIN2,ERCC2
GO:0048646	anatomical structure formation involved in morphogenesis	0.00023603647273016528	0.00023603647273016528	+1	NF1,GATA3,NOTCH1,CTNNB1,RUNX1,AKT1,SOX9,WT1,BRCA1,SETD2,PDGFRA,FGFR2,SMAD4,FOXA2,TGFBR2,SOX17,EGR3,SMAD2
GO:0034613	cellular protein localization	0.00023981435156300365	0.00023981435156300365	+1	TP53,APC,EGFR,PIK3R1,RB1,FBXW7,CTNNB1,CDH1,CTCF,BAP1,NPM1,IDH1,EPHA3,AKT1,BRAF,AR,ATM,U2AF1,ATRX,LRRK2,SETD2,USP9X,BRCA2,ATR,SIN3A,RPL5,AXIN2,RAD21
GO:0060688	regulation of morphogenesis of a branching structure	0.00024053064615782725	0.00024053064615782725	+1	SOX9,HGF,LRRK2,FGFR2
GO:0032879	regulation of localization	0.00024874589384602826	0.00024874589384602826	+1	TP53,PTEN,APC,NAV3,EGFR,NF1,PIK3R1,GATA3,RB1,NOTCH1,FBXW7,CTNNB1,CDH1,BAP1,EPHA3,AKT1,BRAF,AR,EPPK1,SOX9,ATM,HGF,ERBB4,MTOR,TLR4,LRRK2,KIT,SETD2,PDGFRA,FOXA2,SIN3A,PTPN11,ACVR1B,NCOR1
GO:0036294	cellular response to decreased oxygen levels	0.00025516440288578625	0.00025516440288578625	+1	TP53,VHL,NOTCH1,NFE2L2,AJUBA,MTOR,EP300
GO:0090130	tissue migration	0.00025516440288578625	0.00025516440288578625	+1	PIK3CA,PTEN,NF1,GATA3,NOTCH1,AKT1,EPPK1,SOX9,MTOR,KIT,EGR3
GO:0070727	cellular macromolecule localization	0.0002657273417861784	0.0002657273417861784	+1	TP53,APC,EGFR,PIK3R1,RB1,FBXW7,CTNNB1,CDH1,CTCF,BAP1,NPM1,IDH1,EPHA3,AKT1,BRAF,AR,ATM,U2AF1,ATRX,LRRK2,SETD2,USP9X,BRCA2,ATR,SIN3A,RPL5,AXIN2,RAD21
GO:1904892	regulation of receptor signaling pathway via STAT	0.00026856451039152716	0.00026856451039152716	+1	VHL,NOTCH1,FLT3,ERBB4,KIT,FGFR3,PPP2R1A
GO:0045945	positive regulation of transcription by RNA polymerase III	0.00027137732523447515	0.00027137732523447515	+1	CEBPA,AR,MTOR
GO:0034599	cellular response to oxidative stress	0.0002730515593859408	0.0002730515593859408	+1	TP53,EGFR,FBXW7,NFE2L2,AKT1,HGF,TLR4,LRRK2,PDGFRA
GO:0007010	cytoskeleton organization	0.0002765827167973168	0.0002765827167973168	+1	APC,NAV3,NF1,CTNNB1,ARHGAP35,NPM1,CRIPAK,EPHA3,STAG2,AJUBA,EPPK1,MTOR,BRCA1,CHEK2,KIT,SETD2,PDGFRA,SMAD4,BRCA2,SMC1A,SMC3,NCOR1
GO:0003180	aortic valve morphogenesis	0.00028006288943772494	0.00028006288943772494	+1	GATA3,RB1,NOTCH1,SOX9
GO:0010638	positive regulation of organelle organization	0.00030011923545203445	0.00030011923545203445	+1	TP53,NAV3,RB1,FBXW7,CTNNB1,ARHGAP35,BAP1,ATM,ATRX,BRCA1,SMAD4,ATR,SIN3A,RAD21
GO:0071479	cellular response to ionizing radiation	0.0003004992640844765	0.0003004992640844765	+1	TP53,GATA3,ATM,CDKN1A,ATR
GO:0008406	gonad development	0.00030103927350205224	0.00030103927350205224	+1	GATA3,SOX9,WT1,KIT,PDGFRA,BRCA2
GO:0007088	regulation of mitotic nuclear division	0.00031088634770691623	0.00031088634770691623	+1	APC,RB1,STAG2,ATM,ATRX,CCND1,SMC1A,SMC3
GO:0031396	regulation of protein ubiquitination	0.0003239635750248056	0.0003239635750248056	+1	PTEN,CDKN2A,FBXW7,AKT1,BRCA1,LRRK2,TAF1,RPL5
GO:0007179	transforming growth factor beta receptor signaling pathway	0.00033748971001093075	0.00033748971001093075	+1	STK11,EP300,SMAD4,USP9X,TGFBR2,ACVR1B,ACVR2A,SMAD2
GO:0045137	development of primary sexual characteristics	0.00034205272964939014	0.00034205272964939014	+1	GATA3,SOX9,WT1,KIT,PDGFRA,BRCA2
GO:1901800	positive regulation of proteasomal protein catabolic process	0.00034205272964939014	0.00034205272964939014	+1	FBXW7,KEAP1,NFE2L2,CEBPA,LRRK2,TAF1
GO:0061061	muscle structure development	0.00034255782937131615	0.00034255782937131615	+1	RB1,NOTCH1,CTNNB1,TBX3,SOX9,WT1,ERBB4,KIT,PDGFRA,FGFR2,SMAD4,EGR3
GO:1903039	positive regulation of leukocyte cell-cell adhesion	0.0003490143328598714	0.0003490143328598714	+1	PIK3CA,PIK3R1,GATA3,RUNX1,AKT1,TGFBR2,CBFB,PTPN11
GO:0003007	heart morphogenesis	0.0003490143328598714	0.0003490143328598714	+1	GATA3,NOTCH1,CTNNB1,SOX9,FGFR2,SMAD4,TGFBR2,SOX17
GO:0010518	positive regulation of phospholipase activity	0.0003577192963205274	0.0003577192963205274	+1	EGFR,KIT,PDGFRA,FGFR2,FGFR3
GO:0032101	regulation of response to external stimulus	0.00036965612831857056	0.00036965612831857056	+1	PTEN,KRAS,GATA3,RB1,NOTCH1,MAP3K1,NRAS,CEBPA,EPPK1,CDKN1B,TLR4,PDGFRA,EP300,FOXA2,CDKN1A,SIN3A,PTPN11,MIR142
GO:0003176	aortic valve development	0.00037390879289658416	0.00037390879289658416	+1	GATA3,RB1,NOTCH1,SOX9
GO:0070601	centromeric sister chromatid cohesion	0.00037390879289658416	0.00037390879289658416	+1	CTNNB1,CTCF,AXIN2
GO:0048468	cell development	0.0003767080760001526	0.0003767080760001526	+1	PIK3CA,PTEN,NF1,PIK3R1,RB1,NOTCH1,FBXW7,CTNNB1,ARHGAP35,RUNX1,EPHA3,AKT1,SOX9,WT1,ERBB4,LRRK2,KIT,PDGFRA,EP300,FGFR2,SMAD4,USP9X,PTPN11,MIR142
GO:0048562	embryonic organ morphogenesis	0.00039385722516693263	0.00039385722516693263	+1	NOTCH1,CTNNB1,SOX9,PDGFRA,FGFR2,TGFBR2,SOX17
GO:1904868	telomerase catalytic core complex assembly	0.0004192728315089915	0.0004192728315089915	+1	ATM,ATR
GO:1904884	positive regulation of telomerase catalytic core complex assembly	0.0004192728315089915	0.0004192728315089915	+1	ATM,ATR
GO:1904882	regulation of telomerase catalytic core complex assembly	0.0004192728315089915	0.0004192728315089915	+1	ATM,ATR
GO:1905179	negative regulation of cardiac muscle tissue regeneration	0.0004192728315089915	0.0004192728315089915	+1	CDKN1B,CDKN1A
GO:0051548	negative regulation of keratinocyte migration	0.0004192728315089915	0.0004192728315089915	+1	PTEN,EPPK1
GO:0060737	prostate gland morphogenetic growth	0.0004192728315089915	0.0004192728315089915	+1	SOX9,FGFR2
GO:0003208	cardiac ventricle morphogenesis	0.0004203946139485154	0.0004203946139485154	+1	GATA3,NOTCH1,FGFR2,SMAD4,TGFBR2
GO:0048145	regulation of fibroblast proliferation	0.0004203946139485154	0.0004203946139485154	+1	TP53,NF1,CTNNB1,PDGFRA,CDKN1A
GO:0003006	developmental process involved in reproduction	0.000422155368191206	0.000422155368191206	+1	GATA3,TBX3,AR,SOX9,WT1,KIT,PDGFRA,FGFR2,BRCA2,PTPN11
GO:0071453	cellular response to oxygen levels	0.00042433840015618983	0.00042433840015618983	+1	TP53,VHL,NOTCH1,NFE2L2,AJUBA,MTOR,EP300
GO:0035295	tube development	0.00042433840015618983	0.00042433840015618983	+1	NF1,GATA3,NOTCH1,CTNNB1,RUNX1,CEBPA,AKT1,SOX9,WT1,BRCA1,KIT,PDGFRA,FGFR2,TGFBR2,SOX17,EGR3
GO:0019221	cytokine-mediated signaling pathway	0.00042433840015618983	0.00042433840015618983	+1	TP53,PIK3CA,PIK3R1,GATA3,FLT3,RUNX1,CEBPA,AKT1,HGF,KIT,CCND1,SMAD4,CDKN1A,CBFB,PTPN11,LIFR
GO:0043552	positive regulation of phosphatidylinositol 3-kinase activity	0.00042433840015618983	0.00042433840015618983	+1	FLT3,KIT,PDGFRA,FGFR3
GO:0032446	protein modification by small protein conjugation	0.00042433840015618983	0.00042433840015618983	+1	PTEN,VHL,CDKN2A,FBXW7,CTNNB1,KEAP1,NFE2L2,CRIPAK,AKT1,BRCA1,LRRK2,TAF1,CBFB,HIST1H2BD,RPL5
GO:1902275	regulation of chromatin organization	0.00042433840015618983	0.00042433840015618983	+1	CTNNB1,ATRX,BRCA1,HIST1H1C,SMAD4,SIN3A,NSD1
GO:1905330	regulation of morphogenesis of an epithelium	0.00042595984859104477	0.00042595984859104477	+1	PTEN,GATA3,SOX9,HGF,MTOR,FGFR2
GO:2000145	regulation of cell motility	0.0004377057012367719	0.0004377057012367719	+1	PTEN,APC,NAV3,EGFR,NF1,GATA3,NOTCH1,CDH1,AKT1,EPPK1,SOX9,ATM,HGF,ERBB4,MTOR,KIT,PDGFRA,ACVR1B
GO:0046649	lymphocyte activation	0.00044592005660476497	0.00044592005660476497	+1	PIK3CA,PIK3R1,CDKN2A,GATA3,FLT3,RUNX1,AKT1,PIK3CG,ATM,KIT,TGFBR2,CBFB,PTPN11,MAPK8IP1
GO:0051783	regulation of nuclear division	0.0004462115738125933	0.0004462115738125933	+1	APC,RB1,STAG2,ATM,ATRX,CCND1,SMC1A,SMC3
GO:0048144	fibroblast proliferation	0.0004488493213666375	0.0004488493213666375	+1	TP53,NF1,CTNNB1,PDGFRA,CDKN1A
GO:0046661	male sex differentiation	0.0004488493213666375	0.0004488493213666375	+1	GATA3,TBX3,SOX9,WT1,KIT
GO:0046620	regulation of organ growth	0.0004488493213666375	0.0004488493213666375	+1	PTEN,NOTCH1,WT1,ERBB4,FGFR2
GO:0010942	positive regulation of cell death	0.00046958286485944054	0.00046958286485944054	+1	TP53,PTEN,APC,NF1,CDKN2A,NOTCH1,FBXW7,CTNNB1,ATM,CDKN1B,TLR4,LRRK2,FOXA1,AXIN2
GO:0060412	ventricular septum morphogenesis	0.0004767892798237932	0.0004767892798237932	+1	NOTCH1,FGFR2,SMAD4,TGFBR2
GO:0018023	peptidyl-lysine trimethylation	0.0004767892798237932	0.0004767892798237932	+1	TET2,ATRX,HIST1H1C,SETD2
GO:0070198	protein localization to chromosome, telomeric region	0.0004767892798237932	0.0004767892798237932	+1	ATM,ATRX,BRCA2,ATR
GO:0002053	positive regulation of mesenchymal cell proliferation	0.00048604099493216083	0.00048604099493216083	+1	SOX9,FGFR2,TGFBR2
GO:1902105	regulation of leukocyte differentiation	0.0005152363889440851	0.0005152363889440851	+1	CDKN2A,GATA3,FBXW7,RUNX1,MTOR,TLR4,TGFBR2,CBFB
GO:0007259	receptor signaling pathway via JAK-STAT	0.0005275844716041107	0.0005275844716041107	+1	VHL,NOTCH1,FLT3,ERBB4,KIT,FGFR3,PPP2R1A
GO:0002573	myeloid leukocyte differentiation	0.0005275844716041107	0.0005275844716041107	+1	FBXW7,RUNX1,CEBPA,MTOR,TLR4,KIT,TGFBR2
GO:0048568	embryonic organ development	0.0005331100804699872	0.0005331100804699872	+1	NOTCH1,CTNNB1,SOX9,KIT,PDGFRA,FGFR2,TGFBR2,SOX17
GO:0010828	positive regulation of glucose transmembrane transport	0.0005405867835919335	0.0005405867835919335	+1	PIK3R1,AKT1,BRAF,PTPN11
GO:0048709	oligodendrocyte differentiation	0.0005405867835919335	0.0005405867835919335	+1	PTEN,NF1,NOTCH1,SOX9
GO:1903037	regulation of leukocyte cell-cell adhesion	0.000557416918700246	0.000557416918700246	+1	PIK3CA,PIK3R1,CDKN2A,GATA3,RUNX1,AKT1,TGFBR2,CBFB,PTPN11
GO:0031056	regulation of histone modification	0.000561652290181959	0.000561652290181959	+1	CTNNB1,ATRX,BRCA1,SMAD4,SIN3A,NSD1
GO:0051101	regulation of DNA binding	0.000561652290181959	0.000561652290181959	+1	GATA3,RB1,CTNNB1,TAF1,SIN3A,NSD1
GO:0030163	protein catabolic process	0.0005888612122493068	0.0005888612122493068	+1	PTEN,APC,EGFR,CDKN2A,FBXW7,KEAP1,NFE2L2,CEBPA,CDKN1B,MTOR,LRRK2,CHEK2,USP9X,TAF1,TBL1XR1,RPL5,SPOP
GO:0000226	microtubule cytoskeleton organization	0.0005990159458819586	0.0005990159458819586	+1	APC,NAV3,CTNNB1,NPM1,EPHA3,STAG2,BRCA1,CHEK2,SETD2,BRCA2,SMC1A,SMC3,NCOR1
GO:0072594	establishment of protein localization to organelle	0.0005990159458819586	0.0005990159458819586	+1	TP53,PIK3R1,FBXW7,CDH1,BAP1,IDH1,AKT1,ATM,LRRK2,USP9X,BRCA2,ATR,RPL5
GO:0040017	positive regulation of locomotion	0.0005990159458819586	0.0005990159458819586	+1	APC,EGFR,GATA3,NOTCH1,AKT1,SOX9,ATM,HGF,MTOR,KIT,PDGFRA,ACVR1B,SMC3
GO:0061418	regulation of transcription from RNA polymerase II promoter in response to hypoxia	0.0006070236322296698	0.0006070236322296698	+1	VHL,NOTCH1,NFE2L2,EP300
GO:0038128	ERBB2 signaling pathway	0.0006070236322296698	0.0006070236322296698	+1	PIK3CA,EGFR,PIK3R1,ERBB4
GO:0007405	neuroblast proliferation	0.0006070236322296698	0.0006070236322296698	+1	NF1,CTNNB1,LRRK2,FGFR2
GO:0048754	branching morphogenesis of an epithelial tube	0.0006078914348738512	0.0006078914348738512	+1	CTNNB1,SOX9,WT1,FGFR2,TGFBR2
GO:0097696	receptor signaling pathway via STAT	0.000620571621170073	0.000620571621170073	+1	VHL,NOTCH1,FLT3,ERBB4,KIT,FGFR3,PPP2R1A
GO:0030850	prostate gland development	0.0006237397666944902	0.0006237397666944902	+1	AR,SOX9,FGFR2
GO:0051547	regulation of keratinocyte migration	0.0006237397666944902	0.0006237397666944902	+1	PTEN,EPPK1,MTOR
GO:0006979	response to oxidative stress	0.0006301734942511196	0.0006301734942511196	+1	TP53,EGFR,FBXW7,NFE2L2,AKT1,HGF,TLR4,LRRK2,PDGFRA,ERCC2
GO:0016567	protein ubiquitination	0.0006517339027058286	0.0006517339027058286	+1	PTEN,VHL,CDKN2A,FBXW7,KEAP1,NFE2L2,CRIPAK,AKT1,BRCA1,LRRK2,TAF1,CBFB,HIST1H2BD,RPL5
GO:0032481	positive regulation of type I interferon production	0.0006527730149599965	0.0006527730149599965	+1	CTNNB1,TLR4,SETD2,EP300,PTPN11
GO:0090092	regulation of transmembrane receptor protein serine/threonine kinase signaling pathway	0.0006736256005895298	0.0006736256005895298	+1	NOTCH1,STK11,EP300,SMAD4,TGFBR2,ACVR1B,ACVR2A,SMAD2
GO:0090218	positive regulation of lipid kinase activity	0.0006797406361732495	0.0006797406361732495	+1	FLT3,KIT,PDGFRA,FGFR3
GO:0048565	digestive tract development	0.0007022085328429663	0.0007022085328429663	+1	GATA3,KIT,PDGFRA,FGFR2,SOX17
GO:0003279	cardiac septum development	0.0007022085328429663	0.0007022085328429663	+1	GATA3,NOTCH1,FGFR2,SMAD4,TGFBR2
GO:0071902	positive regulation of protein serine/threonine kinase activity	0.0007423105743844872	0.0007423105743844872	+1	EGFR,FLT3,MAP2K4,PIK3CG,TLR4,LRRK2,KIT,CCND1,EZH2
GO:0030855	epithelial cell differentiation	0.0007494125897468664	0.0007494125897468664	+1	GATA3,NOTCH1,CTNNB1,RUNX1,AKT1,SOX9,WT1,ERBB4,ELF3,FGFR2,SOX17,CBFB,VEZF1,ERCC2
GO:0010517	regulation of phospholipase activity	0.0007541003690918522	0.0007541003690918522	+1	EGFR,KIT,PDGFRA,FGFR2,FGFR3
GO:0009057	macromolecule catabolic process	0.0007541003690918522	0.0007541003690918522	+1	PTEN,APC,EGFR,CDKN2A,FBXW7,KEAP1,NFE2L2,NPM1,CEBPA,AKT1,ATM,CDKN1B,MTOR,LRRK2,CHEK2,USP9X,TAF1,PPP2R1A,TBL1XR1,RPL5,SPOP,AXIN2
GO:0060193	positive regulation of lipase activity	0.0007541003690918522	0.0007541003690918522	+1	EGFR,KIT,PDGFRA,FGFR2,FGFR3
GO:0046622	positive regulation of organ growth	0.0007556749658980974	0.0007556749658980974	+1	NOTCH1,WT1,ERBB4,FGFR2
GO:0050731	positive regulation of peptidyl-tyrosine phosphorylation	0.0007556749658980974	0.0007556749658980974	+1	TP53,FBXW7,FLT3,HGF,ERBB4,KIT,FGFR3
GO:0060421	positive regulation of heart growth	0.0007556749658980974	0.0007556749658980974	+1	NOTCH1,WT1,ERBB4,FGFR2
GO:0001708	cell fate specification	0.0007556749658980974	0.0007556749658980974	+1	APC,SOX9,FOXA2,SOX17
GO:0007417	central nervous system development	0.0007680342502618712	0.0007680342502618712	+1	PTEN,NF1,NOTCH1,CTNNB1,ARHGAP35,SOX9,ERBB4,LRRK2,FGFR2,TGFBR2,TAF1,PTPN11,MIR142
GO:0045662	negative regulation of myoblast differentiation	0.0007812423510495422	0.0007812423510495422	+1	NOTCH1,TBX3,SOX9
GO:2001185	regulation of CD8-positive, alpha-beta T cell activation	0.0007812423510495422	0.0007812423510495422	+1	RUNX1,CBFB,MAPK8IP1
GO:0051571	positive regulation of histone H3-K4 methylation	0.0007812423510495422	0.0007812423510495422	+1	CTNNB1,BRCA1,SMAD4
GO:0055123	digestive system development	0.0008017040831526348	0.0008017040831526348	+1	GATA3,KIT,PDGFRA,FGFR2,SOX17
GO:0006508	proteolysis	0.000824604982299615	0.000824604982299615	+1	TP53,PTEN,APC,VHL,CDKN2A,GATA3,FBXW7,KEAP1,NFE2L2,BAP1,CEBPA,AKT1,AR,HGF,BRCA1,LRRK2,SMAD4,USP9X,ASXL1,TAF1,TBL1XR1,RPL5,SMAD2,SPOP
GO:0042246	tissue regeneration	0.0008421202762266979	0.0008421202762266979	+1	EPPK1,CDKN1B,ERBB4,CDKN1A
GO:0008104	protein localization	0.0008493912176857809	0.0008493912176857809	+1	TP53,APC,EGFR,PIK3R1,GATA3,RB1,FBXW7,CTNNB1,KEAP1,CDH1,CTCF,BAP1,NPM1,IDH1,EPHA3,AKT1,BRAF,AR,ATM,TLR4,U2AF1,ATRX,LRRK2,SETD2,FOXA2,USP9X,BRCA2,ATR,SIN3A,RPL5,AXIN2,RAD21
GO:0061045	negative regulation of wound healing	0.0008576566434131427	0.0008576566434131427	+1	PTEN,EPPK1,CDKN1B,PDGFRA,CDKN1A
GO:0010507	negative regulation of autophagy	0.0008576566434131427	0.0008576566434131427	+1	PIK3CA,AKT1,HGF,MTOR,LRRK2
GO:0043406	positive regulation of MAP kinase activity	0.0008685771296085325	0.0008685771296085325	+1	EGFR,FLT3,MAP2K4,PIK3CG,TLR4,LRRK2,KIT,EZH2
GO:0071241	cellular response to inorganic substance	0.0008813397954571953	0.0008813397954571953	+1	EGFR,CDH1,AKT1,BRAF,CDKN1B,ATRX,LRRK2
GO:0051249	regulation of lymphocyte activation	0.0009072817745876581	0.0009072817745876581	+1	PIK3CA,PIK3R1,CDKN2A,GATA3,RUNX1,AKT1,ATM,TGFBR2,CBFB,PTPN11,MAPK8IP1
GO:0048872	homeostasis of number of cells	0.0009274066776609654	0.0009274066776609654	+1	FLT3,AKT1,SOX9,KIT,ACVR1B,ACVR2A
GO:1905314	semi-lunar valve development	0.0009335761225129748	0.0009335761225129748	+1	GATA3,RB1,NOTCH1,SOX9
GO:0030335	positive regulation of cell migration	0.0009582504778840322	0.0009582504778840322	+1	APC,EGFR,GATA3,NOTCH1,AKT1,SOX9,ATM,HGF,MTOR,KIT,PDGFRA,ACVR1B
GO:0003214	cardiac left ventricle morphogenesis	0.0009691315264199005	0.0009691315264199005	+1	NOTCH1,SMAD4,TGFBR2
GO:0022414	reproductive process	0.0009800994215630146	0.0009800994215630146	+1	GATA3,TBX3,AR,SOX9,ATM,WT1,KIT,PDGFRA,FGFR2,USP9X,BRCA2,SMC1A,PTPN11,ACVR1B,SMC3,RAD21
GO:0032147	activation of protein kinase activity	0.0009943157720785235	0.0009943157720785235	+1	MAP3K1,MAP2K4,STK11,AKT1,MTOR,TLR4,LRRK2,KIT,TGFBR2
GO:0051270	regulation of cellular component movement	0.0010274474886796915	0.0010274474886796915	+1	PTEN,APC,NAV3,EGFR,NF1,GATA3,NOTCH1,CDH1,AKT1,EPPK1,SOX9,ATM,HGF,ERBB4,MTOR,KIT,PDGFRA,ACVR1B
GO:0072132	mesenchyme morphogenesis	0.0010283210838208416	0.0010283210838208416	+1	NOTCH1,SOX9,TGFBR2,SMAD2
GO:0097327	response to antineoplastic agent	0.0010283210838208416	0.0010283210838208416	+1	CTNNB1,CDH1,ATRX,BRCA1
GO:0008585	female gonad development	0.0010283210838208416	0.0010283210838208416	+1	WT1,KIT,PDGFRA,BRCA2
GO:0043627	response to estrogen	0.0010283210838208416	0.0010283210838208416	+1	GATA3,CRIPAK,BRCA1,EP300
GO:1901532	regulation of hematopoietic progenitor cell differentiation	0.0010283210838208416	0.0010283210838208416	+1	GATA3,NOTCH1,RUNX1,CBFB
GO:0000003	reproduction	0.0010307923173217073	0.0010307923173217073	+1	GATA3,TBX3,AR,SOX9,ATM,WT1,KIT,PDGFRA,FGFR2,USP9X,BRCA2,SMC1A,PTPN11,ACVR1B,SMC3,RAD21
GO:0097694	establishment of RNA localization to telomere	0.001084078044977907	0.001084078044977907	+1	ATM,ATR
GO:0097695	establishment of protein-containing complex localization to telomere	0.001084078044977907	0.001084078044977907	+1	ATM,ATR
GO:0033600	negative regulation of mammary gland epithelial cell proliferation	0.001084078044977907	0.001084078044977907	+1	GATA3,BRCA2
GO:0071285	cellular response to lithium ion	0.001084078044977907	0.001084078044977907	+1	CDH1,CDKN1B
GO:0060445	branching involved in salivary gland morphogenesis	0.001084078044977907	0.001084078044977907	+1	HGF,FGFR2
GO:0010226	response to lithium ion	0.001084078044977907	0.001084078044977907	+1	CDH1,CDKN1B
GO:2000435	negative regulation of protein neddylation	0.001084078044977907	0.001084078044977907	+1	CDKN2A,RPL5
GO:0032436	positive regulation of proteasomal ubiquitin-dependent protein catabolic process	0.0011033124450996305	0.0011033124450996305	+1	KEAP1,NFE2L2,CEBPA,LRRK2,TAF1
GO:0001889	liver development	0.0011257886799191938	0.0011257886799191938	+1	NF1,FBXW7,CEBPA,ARID5B
GO:0046545	development of primary female sexual characteristics	0.0011257886799191938	0.0011257886799191938	+1	WT1,KIT,PDGFRA,BRCA2
GO:0090183	regulation of kidney development	0.0011257886799191938	0.0011257886799191938	+1	GATA3,CTNNB1,SOX9,WT1
GO:1903829	positive regulation of cellular protein localization	0.001151060448282303	0.001151060448282303	+1	TP53,APC,EGFR,PIK3R1,FBXW7,CDH1,BAP1,EPHA3,AKT1
GO:1902692	regulation of neuroblast proliferation	0.0011570281460796944	0.0011570281460796944	+1	NF1,CTNNB1,LRRK2
GO:1903798	regulation of production of miRNAs involved in gene silencing by miRNA	0.0011570281460796944	0.0011570281460796944	+1	TP53,EGFR,NCOR1
GO:0030856	regulation of epithelial cell differentiation	0.0011570281460796944	0.0011570281460796944	+1	GATA3,CTNNB1,RUNX1,SOX9,CBFB,VEZF1
GO:0061213	positive regulation of mesonephros development	0.0011570281460796944	0.0011570281460796944	+1	GATA3,SOX9,WT1
GO:0010464	regulation of mesenchymal cell proliferation	0.0011570281460796944	0.0011570281460796944	+1	SOX9,FGFR2,TGFBR2
GO:0051546	keratinocyte migration	0.0011570281460796944	0.0011570281460796944	+1	PTEN,EPPK1,MTOR
GO:1902106	negative regulation of leukocyte differentiation	0.0011615297480475626	0.0011615297480475626	+1	CDKN2A,FBXW7,RUNX1,TLR4,CBFB
GO:0042509	regulation of tyrosine phosphorylation of STAT protein	0.0011615297480475626	0.0011615297480475626	+1	FLT3,ERBB4,KIT,FGFR3,PPP2R1A
GO:0002376	immune system process	0.0011928582208511871	0.0011928582208511871	+1	PIK3CA,KRAS,PIK3R1,CDKN2A,GATA3,NOTCH1,FBXW7,MAP3K1,FLT3,RUNX1,NRAS,IDH1,CEBPA,AKT1,PIK3CG,SOX9,ATM,MTOR,TLR4,TET2,POLQ,KIT,SETD2,PDGFRA,EP300,FGFR2,TGFBR2,CBFB,SIN3A,PTPN11,ACVR1B,MAPK8IP1,ACVR2A,MECOM,MIR142
GO:0140014	mitotic nuclear division	0.001197185214326791	0.001197185214326791	+1	APC,RB1,STAG2,ATM,ATRX,CHEK2,CCND1,SMC1A,SMC3
GO:0034614	cellular response to reactive oxygen species	0.001197185214326791	0.001197185214326791	+1	EGFR,NFE2L2,AKT1,HGF,LRRK2,PDGFRA
GO:0035051	cardiocyte differentiation	0.001197185214326791	0.001197185214326791	+1	EGFR,NOTCH1,WT1,PDGFRA,SMAD4,SOX17
GO:0060968	regulation of gene silencing	0.001197185214326791	0.001197185214326791	+1	TP53,EGFR,AJUBA,HIST1H1C,SIN3A,NCOR1
GO:0061008	hepaticobiliary system development	0.001221869761242049	0.001221869761242049	+1	NF1,FBXW7,CEBPA,ARID5B
GO:0048704	embryonic skeletal system morphogenesis	0.001221869761242049	0.001221869761242049	+1	CTNNB1,PDGFRA,FGFR2,TGFBR2
GO:0072073	kidney epithelium development	0.0012288729000646064	0.0012288729000646064	+1	GATA3,CTNNB1,SOX9,WT1,FGFR2
GO:1902749	regulation of cell cycle G2/M phase transition	0.0012454789575038518	0.0012454789575038518	+1	TP53,CDKN2A,NPM1,ATM,BRCA1,CCND1,PPP2R1A
GO:0045834	positive regulation of lipid metabolic process	0.0012457160643028714	0.0012457160643028714	+1	FLT3,AKT1,MTOR,KIT,PDGFRA,FGFR3
GO:0048705	skeletal system morphogenesis	0.0012457160643028714	0.0012457160643028714	+1	CTNNB1,SOX9,PDGFRA,FGFR2,FGFR3,TGFBR2
GO:1903707	negative regulation of hemopoiesis	0.0012457160643028714	0.0012457160643028714	+1	CDKN2A,NOTCH1,FBXW7,RUNX1,TLR4,CBFB
GO:1903321	negative regulation of protein modification by small protein conjugation or removal	0.0013025982533604297	0.0013025982533604297	+1	CDKN2A,CTNNB1,AKT1,TAF1,RPL5
GO:2000379	positive regulation of reactive oxygen species metabolic process	0.0013025982533604297	0.0013025982533604297	+1	TP53,AKT1,TLR4,TGFBR2,CDKN1A
GO:0031929	TOR signaling	0.0013030652583311522	0.0013030652583311522	+1	PIK3CA,GATA3,STK11,AKT1,ATM,MTOR
GO:2000147	positive regulation of cell motility	0.0013244583747725072	0.0013244583747725072	+1	APC,EGFR,GATA3,NOTCH1,AKT1,SOX9,ATM,HGF,MTOR,KIT,PDGFRA,ACVR1B
GO:0048285	organelle fission	0.001358676814912773	0.001358676814912773	+1	APC,RB1,STAG2,ATM,ATRX,LRRK2,CHEK2,CCND1,SMC1A,SMC3,RAD21
GO:0070920	regulation of production of small RNA involved in gene silencing by RNA	0.0013699350934390066	0.0013699350934390066	+1	TP53,EGFR,NCOR1
GO:0036037	CD8-positive, alpha-beta T cell activation	0.0013699350934390066	0.0013699350934390066	+1	RUNX1,CBFB,MAPK8IP1
GO:0048485	sympathetic nervous system development	0.0013699350934390066	0.0013699350934390066	+1	NF1,GATA3,CTNNB1
GO:0033036	macromolecule localization	0.0013699350934390066	0.0013699350934390066	+1	TP53,APC,EGFR,PIK3R1,GATA3,RB1,FBXW7,CTNNB1,KEAP1,CDH1,CTCF,BAP1,NPM1,IDH1,EPHA3,AKT1,BRAF,AR,ATM,TLR4,U2AF1,ATRX,LRRK2,SETD2,FOXA2,USP9X,BRCA2,TGFBR2,ATR,SIN3A,NCOR1,RPL5,AXIN2,RAD21
GO:0044728	DNA methylation or demethylation	0.0013735613165388378	0.0013735613165388378	+1	DNMT3A,WT1,TET2,ATRX,USP9X
GO:1903035	negative regulation of response to wounding	0.0013735613165388378	0.0013735613165388378	+1	PTEN,EPPK1,CDKN1B,PDGFRA,CDKN1A
GO:0007159	leukocyte cell-cell adhesion	0.0013771255432979224	0.0013771255432979224	+1	PIK3CA,PIK3R1,CDKN2A,GATA3,RUNX1,AKT1,TGFBR2,CBFB,PTPN11
GO:1903727	positive regulation of phospholipid metabolic process	0.0014570018707672566	0.0014570018707672566	+1	FLT3,KIT,PDGFRA,FGFR3
GO:0007260	tyrosine phosphorylation of STAT protein	0.0014593406593983117	0.0014593406593983117	+1	FLT3,ERBB4,KIT,FGFR3,PPP2R1A
GO:0035239	tube morphogenesis	0.0014752996042935412	0.0014752996042935412	+1	NF1,GATA3,NOTCH1,CTNNB1,RUNX1,AKT1,SOX9,WT1,BRCA1,PDGFRA,FGFR2,TGFBR2,SOX17,EGR3
GO:0010506	regulation of autophagy	0.0014849220919173874	0.0014849220919173874	+1	PIK3CA,FBXW7,STK11,AKT1,ATM,HGF,MTOR,LRRK2,EP300
GO:0007178	transmembrane receptor protein serine/threonine kinase signaling pathway	0.0014849220919173874	0.0014849220919173874	+1	NOTCH1,STK11,EP300,SMAD4,USP9X,TGFBR2,ACVR1B,ACVR2A,SMAD2
GO:0003231	cardiac ventricle development	0.001546803362268409	0.001546803362268409	+1	GATA3,NOTCH1,FGFR2,SMAD4,TGFBR2
GO:0002011	morphogenesis of an epithelial sheet	0.001591483969440882	0.001591483969440882	+1	PTEN,NOTCH1,ARHGAP35,MTOR
GO:0006310	DNA recombination	0.0016328203722685538	0.0016328203722685538	+1	ATM,BRCA1,POLQ,HIST1H1C,SETD2,BRCA2,RAD21,ERCC2
GO:0051098	regulation of binding	0.001645204430978245	0.001645204430978245	+1	GATA3,RB1,CTNNB1,AKT1,LRRK2,TAF1,SIN3A,NSD1,SMAD2
GO:0051272	positive regulation of cellular component movement	0.0016672804957253856	0.0016672804957253856	+1	APC,EGFR,GATA3,NOTCH1,AKT1,SOX9,ATM,HGF,MTOR,KIT,PDGFRA,ACVR1B
GO:0050680	negative regulation of epithelial cell proliferation	0.0016853810376350243	0.0016853810376350243	+1	NF1,GATA3,FBXW7,EPPK1,SOX9,BRCA2
GO:0001657	ureteric bud development	0.0017329531753923766	0.0017329531753923766	+1	GATA3,SOX9,WT1,FGFR2
GO:0046427	positive regulation of receptor signaling pathway via JAK-STAT	0.0017329531753923766	0.0017329531753923766	+1	NOTCH1,FLT3,ERBB4,KIT,FGFR3
GO:1901216	positive regulation of neuron death	0.0017329531753923766	0.0017329531753923766	+1	NF1,FBXW7,CTNNB1,TLR4
GO:0045927	positive regulation of growth	0.0017454641936594415	0.0017454641936594415	+1	EGFR,NOTCH1,AKT1,WT1,ERBB4,FGFR2,H3F3C
GO:0090287	regulation of cellular response to growth factor stimulus	0.0017712109791977444	0.0017712109791977444	+1	GATA3,NOTCH1,STK11,EP300,FGFR2,SMAD4,TGFBR2,SMAD2
GO:0021953	central nervous system neuron differentiation	0.0018343372575089223	0.0018343372575089223	+1	PTEN,CTNNB1,ARHGAP35,ERBB4,FGFR2
GO:1900408	negative regulation of cellular response to oxidative stress	0.0018797254215653385	0.0018797254215653385	+1	NFE2L2,AKT1,HGF,LRRK2
GO:0072163	mesonephric epithelium development	0.0018797254215653385	0.0018797254215653385	+1	GATA3,SOX9,WT1,FGFR2
GO:0072164	mesonephric tubule development	0.0018797254215653385	0.0018797254215653385	+1	GATA3,SOX9,WT1,FGFR2
GO:1903202	negative regulation of oxidative stress-induced cell death	0.0018797254215653385	0.0018797254215653385	+1	NFE2L2,AKT1,HGF,LRRK2
GO:0048701	embryonic cranial skeleton morphogenesis	0.0018908329489589666	0.0018908329489589666	+1	PDGFRA,FGFR2,TGFBR2
GO:0062009	secondary palate development	0.0018908329489589666	0.0018908329489589666	+1	SMAD4,TGFBR2,SMAD2
GO:0071480	cellular response to gamma radiation	0.0018908329489589666	0.0018908329489589666	+1	TP53,ATM,ATR
GO:0070200	establishment of protein localization to telomere	0.0018908329489589666	0.0018908329489589666	+1	ATM,BRCA2,ATR
GO:0002684	positive regulation of immune system process	0.0018908329489589666	0.0018908329489589666	+1	PIK3CA,KRAS,PIK3R1,GATA3,MAP3K1,RUNX1,NRAS,CEBPA,AKT1,TLR4,EP300,TGFBR2,CBFB,SIN3A,PTPN11,ACVR1B,ACVR2A,MIR142
GO:0061217	regulation of mesonephros development	0.0018908329489589666	0.0018908329489589666	+1	GATA3,SOX9,WT1
GO:0051569	regulation of histone H3-K4 methylation	0.0018908329489589666	0.0018908329489589666	+1	CTNNB1,BRCA1,SMAD4
GO:0031668	cellular response to extracellular stimulus	0.0019089164464474774	0.0019089164464474774	+1	TP53,ARHGAP35,MTOR,LRRK2,FOXA2,CDKN1A,TAF1
GO:0008630	intrinsic apoptotic signaling pathway in response to DNA damage	0.001913744611503669	0.001913744611503669	+1	TP53,ATM,BRCA1,CHEK2,EP300
GO:2000434	regulation of protein neddylation	0.0019356852245007471	0.0019356852245007471	+1	CDKN2A,RPL5
GO:1903223	positive regulation of oxidative stress-induced neuron death	0.0019356852245007471	0.0019356852245007471	+1	FBXW7,TLR4
GO:0006102	isocitrate metabolic process	0.0019356852245007471	0.0019356852245007471	+1	IDH1,IDH2
GO:0060740	prostate gland epithelium morphogenesis	0.0019356852245007471	0.0019356852245007471	+1	SOX9,FGFR2
GO:0071600	otic vesicle morphogenesis	0.0019356852245007471	0.0019356852245007471	+1	SOX9,FGFR2
GO:0030916	otic vesicle formation	0.0019356852245007471	0.0019356852245007471	+1	SOX9,FGFR2
GO:0035522	monoubiquitinated histone H2A deubiquitination	0.0019356852245007471	0.0019356852245007471	+1	BAP1,ASXL1
GO:0035521	monoubiquitinated histone deubiquitination	0.0019356852245007471	0.0019356852245007471	+1	BAP1,ASXL1
GO:2000617	positive regulation of histone H3-K9 acetylation	0.0019356852245007471	0.0019356852245007471	+1	BRCA1,SMAD4
GO:0043378	positive regulation of CD8-positive, alpha-beta T cell differentiation	0.0019356852245007471	0.0019356852245007471	+1	RUNX1,CBFB
GO:1904894	positive regulation of receptor signaling pathway via STAT	0.0019928310083166915	0.0019928310083166915	+1	NOTCH1,FLT3,ERBB4,KIT,FGFR3
GO:0007267	cell-cell signaling	0.0019928310083166915	0.0019928310083166915	+1	PTEN,APC,EGFR,GATA3,CTNNB1,TSHZ3,RUNX1,TBX3,STK11,AKT1,AR,SOX9,HGF,LRRK2,FGFR2,FOXA2,SOX17,PPP2R1A,CBFB,TBL1XR1,AXIN2
GO:0001570	vasculogenesis	0.0019928310083166915	0.0019928310083166915	+1	NOTCH1,WT1,TGFBR2,SOX17
GO:0035196	production of miRNAs involved in gene silencing by miRNA	0.0019928310083166915	0.0019928310083166915	+1	TP53,EGFR,NCOR1,SMAD2
GO:0071772	response to BMP	0.0020106106725755624	0.0020106106725755624	+1	NOTCH1,SOX9,SMAD4,USP9X,ACVR2A,SMAD2
GO:0071773	cellular response to BMP stimulus	0.0020106106725755624	0.0020106106725755624	+1	NOTCH1,SOX9,SMAD4,USP9X,ACVR2A,SMAD2
GO:0007219	Notch signaling pathway	0.0020106106725755624	0.0020106106725755624	+1	EGFR,NOTCH1,FBXW7,AKT1,ELF3,EP300
GO:0032989	cellular component morphogenesis	0.0020691583799561045	0.0020691583799561045	+1	PIK3CA,PTEN,VHL,PIK3R1,RB1,CTNNB1,CDH1,ARHGAP35,EPHA3,LRRK2,KIT,PDGFRA,FGFR2,SMAD4,USP9X,PTPN11
GO:0033157	regulation of intracellular protein transport	0.0021407345959468106	0.0021407345959468106	+1	TP53,PIK3R1,FBXW7,CDH1,BAP1,LRRK2,SETD2
GO:0030098	lymphocyte differentiation	0.002148998715712618	0.002148998715712618	+1	CDKN2A,GATA3,FLT3,RUNX1,ATM,KIT,TGFBR2,CBFB
GO:1902883	negative regulation of response to oxidative stress	0.002151301163456206	0.002151301163456206	+1	NFE2L2,AKT1,HGF,LRRK2
GO:1900034	regulation of cellular response to heat	0.002151301163456206	0.002151301163456206	+1	ATM,MTOR,EP300,ATR
GO:0032925	regulation of activin receptor signaling pathway	0.0021567262472127337	0.0021567262472127337	+1	ACVR1B,ACVR2A,SMAD2
GO:1901673	regulation of mitotic spindle assembly	0.0021567262472127337	0.0021567262472127337	+1	STAG2,SMC1A,SMC3
GO:2001251	negative regulation of chromosome organization	0.0021677681213675714	0.0021677681213675714	+1	APC,ATM,ATRX,BRCA1,HIST1H1C,SIN3A
GO:0001501	skeletal system development	0.0021677681213675714	0.0021677681213675714	+1	FBXW7,CTNNB1,TBX3,SOX9,KIT,PDGFRA,FGFR2,FGFR3,TGFBR2
GO:0009896	positive regulation of catabolic process	0.002191630590855266	0.002191630590855266	+1	PTEN,APC,FBXW7,KEAP1,NFE2L2,STK11,CEBPA,CDKN1B,LRRK2,TAF1
GO:0003206	cardiac chamber morphogenesis	0.0021970675046401283	0.0021970675046401283	+1	GATA3,NOTCH1,FGFR2,SMAD4,TGFBR2
GO:0001503	ossification	0.002251040266530777	0.002251040266530777	+1	EGFR,NF1,NOTCH1,SOX9,HGF,FGFR2,FGFR3,ACVR2A
GO:0031050	dsRNA processing	0.0023014308745700272	0.0023014308745700272	+1	TP53,EGFR,NCOR1,SMAD2
GO:0006383	transcription by RNA polymerase III	0.0023014308745700272	0.0023014308745700272	+1	CEBPA,AR,MTOR,BRCA1
GO:0031295	T cell costimulation	0.0023014308745700272	0.0023014308745700272	+1	PIK3CA,PIK3R1,AKT1,PTPN11
GO:0060420	regulation of heart growth	0.0023014308745700272	0.0023014308745700272	+1	NOTCH1,WT1,ERBB4,FGFR2
GO:0009798	axis specification	0.0023014308745700272	0.0023014308745700272	+1	TBX3,WT1,FOXA2,SMAD2
GO:0070918	production of small RNA involved in gene silencing by RNA	0.0023014308745700272	0.0023014308745700272	+1	TP53,EGFR,NCOR1,SMAD2
GO:1903076	regulation of protein localization to plasma membrane	0.0023014308745700272	0.0023014308745700272	+1	EGFR,PIK3R1,EPHA3,AKT1,AR
GO:2001233	regulation of apoptotic signaling pathway	0.0023015517187347212	0.0023015517187347212	+1	TP53,PTEN,FBXW7,NFE2L2,AKT1,AR,HGF,BRCA1,LRRK2
GO:0042592	homeostatic process	0.0024190142920824265	0.0024190142920824265	+1	APC,NF1,PIK3R1,RB1,NOTCH1,FBXW7,FLT3,NFE2L2,STK11,CEBPA,AKT1,SOX9,ATM,TLR4,ATRX,LRRK2,KIT,PDGFRA,SMAD4,FOXA2,ATR,ACVR1B,ACVR2A
GO:0030219	megakaryocyte differentiation	0.002424588191080295	0.002424588191080295	+1	RUNX1,KIT,EP300,CBFB,SIN3A
GO:0043525	positive regulation of neuron apoptotic process	0.0024555335585524905	0.0024555335585524905	+1	NF1,FBXW7,CTNNB1
GO:0000280	nuclear division	0.0024555335585524905	0.0024555335585524905	+1	APC,RB1,STAG2,ATM,ATRX,CHEK2,CCND1,SMC1A,SMC3,RAD21
GO:1905332	positive regulation of morphogenesis of an epithelium	0.0024555335585524905	0.0024555335585524905	+1	GATA3,SOX9,MTOR
GO:1904666	regulation of ubiquitin protein ligase activity	0.0024555335585524905	0.0024555335585524905	+1	PTEN,CDKN2A,RPL5
GO:2000637	positive regulation of gene silencing by miRNA	0.0024555335585524905	0.0024555335585524905	+1	TP53,EGFR,AJUBA
GO:0010463	mesenchymal cell proliferation	0.0024555335585524905	0.0024555335585524905	+1	SOX9,FGFR2,TGFBR2
GO:0001823	mesonephros development	0.002457776603155307	0.002457776603155307	+1	GATA3,SOX9,WT1,FGFR2
GO:0060993	kidney morphogenesis	0.002457776603155307	0.002457776603155307	+1	GATA3,SOX9,WT1,LRRK2
GO:0031294	lymphocyte costimulation	0.002457776603155307	0.002457776603155307	+1	PIK3CA,PIK3R1,AKT1,PTPN11
GO:0120163	negative regulation of cold-induced thermogenesis	0.002457776603155307	0.002457776603155307	+1	RB1,NOTCH1,STK11,TLR4
GO:0043254	regulation of protein complex assembly	0.0024826032718391526	0.0024826032718391526	+1	TP53,NAV3,RB1,AJUBA,ATM,TLR4,EP300,ATR,PTPN11,ERCC2
GO:1903708	positive regulation of hemopoiesis	0.0024834657246223754	0.0024834657246223754	+1	GATA3,RUNX1,TGFBR2,CBFB,ACVR1B,ACVR2A
GO:0060284	regulation of cell development	0.0024834657246223754	0.0024834657246223754	+1	PTEN,NF1,NOTCH1,FBXW7,CTNNB1,ARHGAP35,EPHA3,AKT1,SOX9,LRRK2,EP300,SMAD4,MIR142
GO:0072006	nephron development	0.0025138526786233186	0.0025138526786233186	+1	GATA3,CTNNB1,SOX9,WT1,PDGFRA
GO:0090263	positive regulation of canonical Wnt signaling pathway	0.0025138526786233186	0.0025138526786233186	+1	EGFR,LRRK2,FGFR2,TBL1XR1,AXIN2
GO:0045321	leukocyte activation	0.0025558599398436857	0.0025558599398436857	+1	PIK3CA,PIK3R1,CDKN2A,GATA3,FLT3,RUNX1,NRAS,IDH1,CEBPA,AKT1,PIK3CG,ATM,TLR4,KIT,TGFBR2,CBFB,PTPN11,MAPK8IP1,MIR142
GO:0006928	movement of cell or subcellular component	0.0025638039276261243	0.0025638039276261243	+1	PIK3CA,PTEN,APC,NAV3,EGFR,NF1,PIK3R1,GATA3,NOTCH1,CDH1,ARHGAP35,EPHA3,AKT1,EPPK1,PIK3CG,SOX9,ATM,HGF,ERBB4,MTOR,LRRK2,KIT,PDGFRA,USP9X,PTPN11,ACVR1B,EGR3
GO:0070925	organelle assembly	0.002606731405803202	0.002606731405803202	+1	PTEN,NOTCH1,ARHGAP35,NPM1,STAG2,BRCA1,LRRK2,CHEK2,PDGFRA,SMAD4,PPP2R1A,SMC1A,SMC3,NCOR1,RPL5
GO:0072080	nephron tubule development	0.0026286421254087824	0.0026286421254087824	+1	GATA3,CTNNB1,SOX9,WT1
GO:0071260	cellular response to mechanical stimulus	0.0026286421254087824	0.0026286421254087824	+1	MAP3K1,MAP2K4,SOX9,TLR4
GO:0008584	male gonad development	0.0026286421254087824	0.0026286421254087824	+1	GATA3,SOX9,WT1,KIT
GO:0060191	regulation of lipase activity	0.002631417906183187	0.002631417906183187	+1	EGFR,KIT,PDGFRA,FGFR2,FGFR3
GO:0006511	ubiquitin-dependent protein catabolic process	0.002653222775649848	0.002653222775649848	+1	PTEN,CDKN2A,FBXW7,KEAP1,NFE2L2,CEBPA,LRRK2,USP9X,TAF1,TBL1XR1,RPL5,SPOP
GO:0000086	G2/M transition of mitotic cell cycle	0.002653804006340076	0.002653804006340076	+1	CDKN2A,AJUBA,ATM,CHEK2,CCND1,CDKN1A,PPP2R1A
GO:0048514	blood vessel morphogenesis	0.002693761656873224	0.002693761656873224	+1	NF1,NOTCH1,CTNNB1,RUNX1,AKT1,WT1,BRCA1,PDGFRA,FGFR2,TGFBR2,SOX17,EGR3
GO:0060148	positive regulation of posttranscriptional gene silencing	0.002747165501618599	0.002747165501618599	+1	TP53,EGFR,AJUBA
GO:0000578	embryonic axis specification	0.002747165501618599	0.002747165501618599	+1	TBX3,WT1,SMAD2
GO:0043032	positive regulation of macrophage activation	0.002747165501618599	0.002747165501618599	+1	CEBPA,TLR4,MIR142
GO:0030513	positive regulation of BMP signaling pathway	0.002747165501618599	0.002747165501618599	+1	NOTCH1,SMAD4,SMAD2
GO:0110111	negative regulation of animal organ morphogenesis	0.002747165501618599	0.002747165501618599	+1	GATA3,NOTCH1,FBXW7
GO:0048806	genitalia development	0.002747165501618599	0.002747165501618599	+1	TBX3,WT1,PTPN11
GO:0007064	mitotic sister chromatid cohesion	0.002747165501618599	0.002747165501618599	+1	RB1,ATRX,SMC1A
GO:2000679	positive regulation of transcription regulatory region DNA binding	0.002747165501618599	0.002747165501618599	+1	GATA3,RB1,CTNNB1
GO:0048546	digestive tract morphogenesis	0.002747165501618599	0.002747165501618599	+1	PDGFRA,FGFR2,SOX17
GO:0030168	platelet activation	0.002747165501618599	0.002747165501618599	+1	PIK3CA,PIK3R1,PIK3CG,TLR4,PDGFRA,PTPN11
GO:0019941	modification-dependent protein catabolic process	0.002752509406920325	0.002752509406920325	+1	PTEN,CDKN2A,FBXW7,KEAP1,NFE2L2,CEBPA,LRRK2,USP9X,TAF1,TBL1XR1,RPL5,SPOP
GO:0060411	cardiac septum morphogenesis	0.002779298268505892	0.002779298268505892	+1	NOTCH1,FGFR2,SMAD4,TGFBR2
GO:0046546	development of primary male sexual characteristics	0.002779298268505892	0.002779298268505892	+1	GATA3,SOX9,WT1,KIT
GO:0061326	renal tubule development	0.002779298268505892	0.002779298268505892	+1	GATA3,CTNNB1,SOX9,WT1
GO:0048706	embryonic skeletal system development	0.002779298268505892	0.002779298268505892	+1	CTNNB1,PDGFRA,FGFR2,TGFBR2
GO:0071248	cellular response to metal ion	0.002824007166095501	0.002824007166095501	+1	EGFR,CDH1,AKT1,BRAF,CDKN1B,LRRK2
GO:0010001	glial cell differentiation	0.0028532293807736085	0.0028532293807736085	+1	PTEN,NF1,NOTCH1,SOX9,MIR142
GO:0097305	response to alcohol	0.0028532293807736085	0.0028532293807736085	+1	CTNNB1,CDH1,BRCA1,TGFBR2,SMAD2
GO:0060736	prostate gland growth	0.0028896387666760355	0.0028896387666760355	+1	SOX9,FGFR2
GO:0061419	positive regulation of transcription from RNA polymerase II promoter in response to hypoxia	0.0028896387666760355	0.0028896387666760355	+1	NOTCH1,NFE2L2
GO:1902498	regulation of protein autoubiquitination	0.0028896387666760355	0.0028896387666760355	+1	LRRK2,TAF1
GO:1901723	negative regulation of cell proliferation involved in kidney development	0.0028896387666760355	0.0028896387666760355	+1	GATA3,WT1
GO:2000020	positive regulation of male gonad development	0.0028896387666760355	0.0028896387666760355	+1	SOX9,WT1
GO:2000377	regulation of reactive oxygen species metabolic process	0.0028896387666760355	0.0028896387666760355	+1	TP53,AKT1,TLR4,BRCA1,TGFBR2,CDKN1A
GO:0003149	membranous septum morphogenesis	0.0028896387666760355	0.0028896387666760355	+1	FGFR2,TGFBR2
GO:2001187	positive regulation of CD8-positive, alpha-beta T cell activation	0.0028896387666760355	0.0028896387666760355	+1	RUNX1,CBFB
GO:0003160	endocardium morphogenesis	0.0028896387666760355	0.0028896387666760355	+1	NOTCH1,SOX17
GO:0048853	forebrain morphogenesis	0.0028896387666760355	0.0028896387666760355	+1	PTEN,NF1
GO:0060729	intestinal epithelial structure maintenance	0.0028896387666760355	0.0028896387666760355	+1	SOX9,TLR4
GO:0060512	prostate gland morphogenesis	0.0028896387666760355	0.0028896387666760355	+1	SOX9,FGFR2
GO:0042493	response to drug	0.0029309880205394376	0.0029309880205394376	+1	TP53,CTNNB1,CDH1,NFE2L2,SOX9,HGF,ATRX,BRCA1,LRRK2,CCND1,TGFBR2,TAF1
GO:1903078	positive regulation of protein localization to plasma membrane	0.002941978930457002	0.002941978930457002	+1	EGFR,PIK3R1,EPHA3,AKT1
GO:0000302	response to reactive oxygen species	0.0029954446292742363	0.0029954446292742363	+1	EGFR,NFE2L2,AKT1,HGF,LRRK2,PDGFRA
GO:1903846	positive regulation of cellular response to transforming growth factor beta stimulus	0.0030687682554658706	0.0030687682554658706	+1	STK11,EP300,SMAD4
GO:0030511	positive regulation of transforming growth factor beta receptor signaling pathway	0.0030687682554658706	0.0030687682554658706	+1	STK11,EP300,SMAD4
GO:0043009	chordate embryonic development	0.0030802313592494302	0.0030802313592494302	+1	GATA3,CTNNB1,SOX9,BRCA1,PDGFRA,FGFR2,TGFBR2
GO:0051438	regulation of ubiquitin-protein transferase activity	0.0031508028519607	0.0031508028519607	+1	PTEN,CDKN2A,FBXW7,RPL5
GO:0010827	regulation of glucose transmembrane transport	0.0031508028519607	0.0031508028519607	+1	PIK3R1,AKT1,BRAF,PTPN11
GO:0043632	modification-dependent macromolecule catabolic process	0.003217920940136189	0.003217920940136189	+1	PTEN,CDKN2A,FBXW7,KEAP1,NFE2L2,CEBPA,LRRK2,USP9X,TAF1,TBL1XR1,RPL5,SPOP
GO:2001020	regulation of response to DNA damage stimulus	0.0032650152156386883	0.0032650152156386883	+1	EGFR,ATM,BRCA1,POLQ,SETD2,ATR,AXIN2
GO:0043966	histone H3 acetylation	0.0033810722465548843	0.0033810722465548843	+1	BRCA1,SMAD4,BRCA2,SIN3A
GO:0048667	cell morphogenesis involved in neuron differentiation	0.003386628065767015	0.003386628065767015	+1	PIK3CA,PTEN,PIK3R1,RB1,ARHGAP35,EPHA3,LRRK2,FGFR2,USP9X,PTPN11
GO:0034622	cellular protein-containing complex assembly	0.003395470649885879	0.003395470649885879	+1	TP53,NAV3,RB1,NPM1,SOX9,ATM,TLR4,ATRX,SMAD4,SF3B1,TAF1,ATR,HIST1H2BD,H3F3C,RPL5,SMAD2,ERCC2
GO:0006304	DNA modification	0.0033965175427705416	0.0033965175427705416	+1	DNMT3A,WT1,TET2,ATRX,USP9X
GO:0072210	metanephric nephron development	0.003443549752905999	0.003443549752905999	+1	SOX9,WT1,PDGFRA
GO:2001039	negative regulation of cellular response to drug	0.003443549752905999	0.003443549752905999	+1	NFE2L2,HGF,LRRK2
GO:1903206	negative regulation of hydrogen peroxide-induced cell death	0.003443549752905999	0.003443549752905999	+1	NFE2L2,HGF,LRRK2
GO:1901032	negative regulation of response to reactive oxygen species	0.003443549752905999	0.003443549752905999	+1	NFE2L2,HGF,LRRK2
GO:0009056	catabolic process	0.003443549752905999	0.003443549752905999	+1	TP53,PIK3CA,PTEN,APC,EGFR,CDKN2A,FBXW7,KEAP1,NFE2L2,NPM1,IDH1,STK11,CEBPA,AKT1,ATM,CDKN1B,HGF,MTOR,TET2,LRRK2,CHEK2,EP300,USP9X,TAF1,PPP2R1A,TBL1XR1,NCOR1,RPL5,SPOP,AXIN2
GO:0071168	protein localization to chromatin	0.003443549752905999	0.003443549752905999	+1	RB1,SETD2,RAD21
GO:0044265	cellular macromolecule catabolic process	0.003443549752905999	0.003443549752905999	+1	PTEN,CDKN2A,FBXW7,KEAP1,NFE2L2,NPM1,CEBPA,AKT1,ATM,LRRK2,CHEK2,USP9X,TAF1,PPP2R1A,TBL1XR1,RPL5,SPOP,AXIN2
GO:0001525	angiogenesis	0.0034961694720443545	0.0034961694720443545	+1	NF1,NOTCH1,CTNNB1,RUNX1,AKT1,BRCA1,PDGFRA,FGFR2,TGFBR2,SOX17,EGR3
GO:0048738	cardiac muscle tissue development	0.0035471451816191397	0.0035471451816191397	+1	NOTCH1,WT1,ERBB4,PDGFRA,FGFR2,SMAD4
GO:0051641	cellular localization	0.0036665830364366156	0.0036665830364366156	+1	TP53,PTEN,APC,EGFR,PIK3R1,RB1,FBXW7,CTNNB1,CDH1,CTCF,BAP1,NPM1,IDH1,EPHA3,AKT1,BRAF,AR,PIK3CG,ATM,U2AF1,ATRX,LRRK2,KIT,SETD2,FOXA2,USP9X,BRCA2,PPP2R1A,ATR,SIN3A,RPL5,AXIN2,RAD21
GO:0010035	response to inorganic substance	0.0036754882750714875	0.0036754882750714875	+1	EGFR,CDH1,NFE2L2,AKT1,BRAF,CDKN1B,HGF,ATRX,LRRK2
GO:1904375	regulation of protein localization to cell periphery	0.0036971934965269355	0.0036971934965269355	+1	EGFR,PIK3R1,EPHA3,AKT1,AR
GO:0001775	cell activation	0.0037797258426442502	0.0037797258426442502	+1	PIK3CA,PIK3R1,CDKN2A,GATA3,FLT3,RUNX1,NRAS,IDH1,CEBPA,AKT1,PIK3CG,ATM,TLR4,KIT,PDGFRA,TGFBR2,CBFB,PTPN11,MAPK8IP1,MIR142
GO:0045582	positive regulation of T cell differentiation	0.003825961547849931	0.003825961547849931	+1	GATA3,RUNX1,TGFBR2,CBFB
GO:0045580	regulation of T cell differentiation	0.003845869938233823	0.003845869938233823	+1	CDKN2A,GATA3,RUNX1,TGFBR2,CBFB
GO:2000144	positive regulation of DNA-templated transcription, initiation	0.003845869938233823	0.003845869938233823	+1	TP53,CTNNB1,TAF1
GO:0003148	outflow tract septum morphogenesis	0.003845869938233823	0.003845869938233823	+1	FGFR2,SMAD4,TGFBR2
GO:1902175	regulation of oxidative stress-induced intrinsic apoptotic signaling pathway	0.003845869938233823	0.003845869938233823	+1	FBXW7,NFE2L2,AKT1
GO:0061647	histone H3-K9 modification	0.003845869938233823	0.003845869938233823	+1	ATRX,BRCA1,SMAD4
GO:0046326	positive regulation of glucose import	0.003845869938233823	0.003845869938233823	+1	PIK3R1,AKT1,PTPN11
GO:0048483	autonomic nervous system development	0.003845869938233823	0.003845869938233823	+1	NF1,GATA3,CTNNB1
GO:0003205	cardiac chamber development	0.003845869938233823	0.003845869938233823	+1	GATA3,NOTCH1,FGFR2,SMAD4,TGFBR2
GO:0030162	regulation of proteolysis	0.003934785635383758	0.003934785635383758	+1	PTEN,CDKN2A,FBXW7,KEAP1,NFE2L2,CEBPA,AKT1,HGF,LRRK2,TAF1,RPL5,SPOP
GO:0009612	response to mechanical stimulus	0.004015565803731229	0.004015565803731229	+1	MAP3K1,MAP2K4,SOX9,TLR4,KIT
GO:0050679	positive regulation of epithelial cell proliferation	0.0040388415275164485	0.0040388415275164485	+1	EGFR,NRAS,AKT1,SOX9,FGFR2,EGR3
GO:2000739	regulation of mesenchymal stem cell differentiation	0.004041280108024573	0.004041280108024573	+1	SOX9,PDGFRA
GO:0048715	negative regulation of oligodendrocyte differentiation	0.004041280108024573	0.004041280108024573	+1	NF1,NOTCH1
GO:0030539	male genitalia development	0.004041280108024573	0.004041280108024573	+1	TBX3,WT1
GO:0003348	cardiac endothelial cell differentiation	0.004041280108024573	0.004041280108024573	+1	NOTCH1,SOX17
GO:0045445	myoblast differentiation	0.004041280108024573	0.004041280108024573	+1	RB1,NOTCH1,TBX3,SOX9
GO:2000018	regulation of male gonad development	0.004041280108024573	0.004041280108024573	+1	SOX9,WT1
GO:0060956	endocardial cell differentiation	0.004041280108024573	0.004041280108024573	+1	NOTCH1,SOX17
GO:1905941	positive regulation of gonad development	0.004041280108024573	0.004041280108024573	+1	SOX9,WT1
GO:1905634	regulation of protein localization to chromatin	0.004041280108024573	0.004041280108024573	+1	RB1,SETD2
GO:0048755	branching morphogenesis of a nerve	0.004041280108024573	0.004041280108024573	+1	LRRK2,FGFR2
GO:1905178	regulation of cardiac muscle tissue regeneration	0.004041280108024573	0.004041280108024573	+1	CDKN1B,CDKN1A
GO:1905323	telomerase holoenzyme complex assembly	0.004041280108024573	0.004041280108024573	+1	ATM,ATR
GO:0048666	neuron development	0.004041280108024573	0.004041280108024573	+1	PIK3CA,PTEN,PIK3R1,RB1,CTNNB1,ARHGAP35,RUNX1,EPHA3,AKT1,LRRK2,EP300,FGFR2,USP9X,PTPN11
GO:0090394	negative regulation of excitatory postsynaptic potential	0.004041280108024573	0.004041280108024573	+1	PTEN,LRRK2
GO:0043376	regulation of CD8-positive, alpha-beta T cell differentiation	0.004041280108024573	0.004041280108024573	+1	RUNX1,CBFB
GO:0071599	otic vesicle development	0.004041280108024573	0.004041280108024573	+1	SOX9,FGFR2
GO:0001568	blood vessel development	0.00411025974630579	0.00411025974630579	+1	NF1,NOTCH1,CTNNB1,RUNX1,AKT1,WT1,BRCA1,PDGFRA,FGFR2,TGFBR2,SOX17,EGR3
GO:0017015	regulation of transforming growth factor beta receptor signaling pathway	0.004120527304771952	0.004120527304771952	+1	STK11,EP300,SMAD4,TGFBR2,SMAD2
GO:1902036	regulation of hematopoietic stem cell differentiation	0.004224277950388675	0.004224277950388675	+1	GATA3,RUNX1,CBFB
GO:0010332	response to gamma radiation	0.004224277950388675	0.004224277950388675	+1	TP53,ATM,ATR
GO:1904377	positive regulation of protein localization to cell periphery	0.004224277950388675	0.004224277950388675	+1	EGFR,PIK3R1,EPHA3,AKT1
GO:0090307	mitotic spindle assembly	0.004224277950388675	0.004224277950388675	+1	STAG2,CHEK2,SMC1A,SMC3
GO:0090169	regulation of spindle assembly	0.004224277950388675	0.004224277950388675	+1	STAG2,SMC1A,SMC3
GO:1903844	regulation of cellular response to transforming growth factor beta stimulus	0.004284260783010724	0.004284260783010724	+1	STK11,EP300,SMAD4,TGFBR2,SMAD2
GO:0051225	spindle assembly	0.004284260783010724	0.004284260783010724	+1	STAG2,CHEK2,SMC1A,SMC3,NCOR1
GO:1905475	regulation of protein localization to membrane	0.004364618847338055	0.004364618847338055	+1	TP53,EGFR,PIK3R1,EPHA3,AKT1,AR
GO:0061136	regulation of proteasomal protein catabolic process	0.004364618847338055	0.004364618847338055	+1	FBXW7,KEAP1,NFE2L2,CEBPA,LRRK2,TAF1
GO:0070661	leukocyte proliferation	0.004386284546931676	0.004386284546931676	+1	CDKN2A,FLT3,PIK3CG,ATM,KIT,TGFBR2,MAPK8IP1
GO:0009792	embryo development ending in birth or egg hatching	0.004386284546931676	0.004386284546931676	+1	GATA3,CTNNB1,SOX9,BRCA1,PDGFRA,FGFR2,TGFBR2
GO:0010632	regulation of epithelial cell migration	0.00438788183126663	0.00438788183126663	+1	PTEN,NF1,GATA3,NOTCH1,AKT1,EPPK1,SOX9,MTOR
GO:0018107	peptidyl-threonine phosphorylation	0.004447391825747606	0.004447391825747606	+1	AKT1,LRRK2,TGFBR2,TAF1,ACVR1B
GO:0031214	biomineral tissue development	0.004447391825747606	0.004447391825747606	+1	NOTCH1,SOX9,FGFR2,FGFR3,ACVR2A
GO:0002683	negative regulation of immune system process	0.004447391825747606	0.004447391825747606	+1	CDKN2A,NOTCH1,FBXW7,RUNX1,AKT1,SOX9,ATM,TLR4,CBFB
GO:0055024	regulation of cardiac muscle tissue development	0.004461395915684547	0.004461395915684547	+1	NOTCH1,ERBB4,FGFR2,SMAD4
GO:0034329	cell junction assembly	0.004611023226143574	0.004611023226143574	+1	PTEN,APC,CTNNB1,CDH1,RUNX1,EPHA3,CBFB
GO:0072593	reactive oxygen species metabolic process	0.004611023226143574	0.004611023226143574	+1	TP53,AKT1,TLR4,BRCA1,LRRK2,TGFBR2,CDKN1A
GO:0030217	T cell differentiation	0.004629788863967852	0.004629788863967852	+1	CDKN2A,GATA3,RUNX1,KIT,TGFBR2,CBFB
GO:0032434	regulation of proteasomal ubiquitin-dependent protein catabolic process	0.004629788863967852	0.004629788863967852	+1	KEAP1,NFE2L2,CEBPA,LRRK2,TAF1
GO:0048645	animal organ formation	0.004654866973197993	0.004654866973197993	+1	WT1,FGFR2,SOX17
GO:0060045	positive regulation of cardiac muscle cell proliferation	0.004654866973197993	0.004654866973197993	+1	NOTCH1,ERBB4,FGFR2
GO:0031175	neuron projection development	0.0046789741121603745	0.0046789741121603745	+1	PIK3CA,PTEN,PIK3R1,RB1,CTNNB1,ARHGAP35,EPHA3,AKT1,LRRK2,EP300,FGFR2,USP9X,PTPN11
GO:0045815	positive regulation of gene expression, epigenetic	0.00471153142039221	0.00471153142039221	+1	ARID1A,HIST1H1C,EP300,SF3B1
GO:0060419	heart growth	0.00471153142039221	0.00471153142039221	+1	NOTCH1,WT1,ERBB4,FGFR2
GO:0031099	regeneration	0.00471153142039221	0.00471153142039221	+1	EPPK1,CDKN1B,ERBB4,CDKN1A
GO:0050767	regulation of neurogenesis	0.004812561936178388	0.004812561936178388	+1	PTEN,NF1,NOTCH1,CTNNB1,ARHGAP35,EPHA3,AKT1,SOX9,LRRK2,EP300,MIR142
GO:0007420	brain development	0.004972327854315731	0.004972327854315731	+1	PTEN,NF1,CTNNB1,ERBB4,LRRK2,FGFR2,TGFBR2,TAF1,PTPN11
GO:1905477	positive regulation of protein localization to membrane	0.0050098524892389735	0.0050098524892389735	+1	TP53,EGFR,PIK3R1,EPHA3,AKT1
GO:0009408	response to heat	0.0050098524892389735	0.0050098524892389735	+1	AKT1,ATM,MTOR,EP300,ATR
GO:0010821	regulation of mitochondrion organization	0.005071664100223143	0.005071664100223143	+1	TP53,FBXW7,BAP1,AKT1,HGF,LRRK2
GO:2001024	negative regulation of response to drug	0.005134185254164743	0.005134185254164743	+1	NFE2L2,HGF,LRRK2
GO:1903205	regulation of hydrogen peroxide-induced cell death	0.005134185254164743	0.005134185254164743	+1	NFE2L2,HGF,LRRK2
GO:0003203	endocardial cushion morphogenesis	0.005134185254164743	0.005134185254164743	+1	NOTCH1,SOX9,TGFBR2
GO:0070199	establishment of protein localization to chromosome	0.005134185254164743	0.005134185254164743	+1	ATM,BRCA2,ATR
GO:0051251	positive regulation of lymphocyte activation	0.005187743746603574	0.005187743746603574	+1	PIK3CA,PIK3R1,GATA3,RUNX1,AKT1,TGFBR2,CBFB,PTPN11
GO:0035148	tube formation	0.005282119936641684	0.005282119936641684	+1	GATA3,NOTCH1,SOX9,FGFR2
GO:0035270	endocrine system development	0.005282119936641684	0.005282119936641684	+1	NF1,AKT1,WT1,FOXA2
GO:0071481	cellular response to X-ray	0.005323720141916819	0.005323720141916819	+1	GATA3,ATM
GO:0043970	histone H3-K9 acetylation	0.005323720141916819	0.005323720141916819	+1	BRCA1,SMAD4
GO:2000615	regulation of histone H3-K9 acetylation	0.005323720141916819	0.005323720141916819	+1	BRCA1,SMAD4
GO:0062043	positive regulation of cardiac epithelial to mesenchymal transition	0.005323720141916819	0.005323720141916819	+1	NOTCH1,TGFBR2
GO:1902969	mitotic DNA replication	0.005323720141916819	0.005323720141916819	+1	CHEK2,BRCA2
GO:0071371	cellular response to gonadotropin stimulus	0.005323720141916819	0.005323720141916819	+1	NOTCH1,WT1
GO:0060602	branch elongation of an epithelium	0.005323720141916819	0.005323720141916819	+1	SOX9,FGFR2
GO:0008340	determination of adult lifespan	0.005323720141916819	0.005323720141916819	+1	TP53,LRRK2
GO:0002327	immature B cell differentiation	0.005323720141916819	0.005323720141916819	+1	ATM,KIT
GO:0007435	salivary gland morphogenesis	0.005323720141916819	0.005323720141916819	+1	HGF,FGFR2
GO:1903689	regulation of wound healing, spreading of epidermal cells	0.005323720141916819	0.005323720141916819	+1	PTEN,MTOR
GO:0000902	cell morphogenesis	0.005373151418169505	0.005373151418169505	+1	PIK3CA,PTEN,VHL,PIK3R1,RB1,CTNNB1,CDH1,ARHGAP35,EPHA3,LRRK2,KIT,FGFR2,USP9X,PTPN11
GO:0006629	lipid metabolic process	0.005504676861456634	0.005504676861456634	+1	PIK3CA,PTEN,PIK3R1,RB1,FBXW7,FLT3,IDH1,AKT1,PIK3CG,MTOR,BRCA1,KIT,PDGFRA,FGFR3,B4GALT3,PPP2R1A,SIN3A,TBL1XR1,NCOR1
GO:0061919	process utilizing autophagic mechanism	0.005518342797979534	0.005518342797979534	+1	TP53,PIK3CA,FBXW7,STK11,AKT1,ATM,HGF,MTOR,LRRK2,EP300
GO:0006914	autophagy	0.005518342797979534	0.005518342797979534	+1	TP53,PIK3CA,FBXW7,STK11,AKT1,ATM,HGF,MTOR,LRRK2,EP300
GO:0042531	positive regulation of tyrosine phosphorylation of STAT protein	0.005518342797979534	0.005518342797979534	+1	FLT3,ERBB4,KIT,FGFR3
GO:0045621	positive regulation of lymphocyte differentiation	0.005518342797979534	0.005518342797979534	+1	GATA3,RUNX1,TGFBR2,CBFB
GO:1904888	cranial skeletal system development	0.005532754485183989	0.005532754485183989	+1	PDGFRA,FGFR2,TGFBR2
GO:0031062	positive regulation of histone methylation	0.005532754485183989	0.005532754485183989	+1	CTNNB1,BRCA1,SMAD4
GO:0071364	cellular response to epidermal growth factor stimulus	0.005532754485183989	0.005532754485183989	+1	EGFR,SOX9,PTPN11
GO:0032479	regulation of type I interferon production	0.005532754485183989	0.005532754485183989	+1	CTNNB1,TLR4,SETD2,EP300,PTPN11
GO:0044319	wound healing, spreading of cells	0.005532754485183989	0.005532754485183989	+1	PTEN,ARHGAP35,MTOR
GO:0009948	anterior/posterior axis specification	0.005532754485183989	0.005532754485183989	+1	TBX3,WT1,FOXA2
GO:0031334	positive regulation of protein complex assembly	0.005532754485183989	0.005532754485183989	+1	TP53,NAV3,AJUBA,ATM,TLR4,ATR,ERCC2
GO:0090184	positive regulation of kidney development	0.005532754485183989	0.005532754485183989	+1	GATA3,SOX9,WT1
GO:0032606	type I interferon production	0.005532754485183989	0.005532754485183989	+1	CTNNB1,TLR4,SETD2,EP300,PTPN11
GO:0090505	epiboly involved in wound healing	0.005532754485183989	0.005532754485183989	+1	PTEN,ARHGAP35,MTOR
GO:0010719	negative regulation of epithelial to mesenchymal transition	0.005532754485183989	0.005532754485183989	+1	PTEN,FOXA1,FOXA2
GO:0060537	muscle tissue development	0.00562455408817164	0.00562455408817164	+1	NF1,NOTCH1,WT1,ERBB4,PDGFRA,FGFR2,SMAD4
GO:0006289	nucleotide-excision repair	0.005723409116783087	0.005723409116783087	+1	TP53,CRIPAK,EP300,BRCA2,ERCC2
GO:0090398	cellular senescence	0.005778481268774256	0.005778481268774256	+1	TP53,CDKN2A,TBX3,CDKN1A
GO:0060348	bone development	0.005939123036466055	0.005939123036466055	+1	FBXW7,SOX9,KIT,FGFR2,FGFR3
GO:0031669	cellular response to nutrient levels	0.005939123036466055	0.005939123036466055	+1	TP53,MTOR,LRRK2,FOXA2,CDKN1A,TAF1
GO:0008286	insulin receptor signaling pathway	0.005939123036466055	0.005939123036466055	+1	PIK3CA,APC,PIK3R1,AKT1,PTPN11
GO:0018210	peptidyl-threonine modification	0.005939123036466055	0.005939123036466055	+1	AKT1,LRRK2,TGFBR2,TAF1,ACVR1B
GO:0048640	negative regulation of developmental growth	0.006051773313375254	0.006051773313375254	+1	PTEN,CDKN1B,FGFR3,CDKN1A
GO:0044257	cellular protein catabolic process	0.006051773313375254	0.006051773313375254	+1	PTEN,CDKN2A,FBXW7,KEAP1,NFE2L2,CEBPA,LRRK2,CHEK2,USP9X,TAF1,TBL1XR1,RPL5,SPOP
GO:0045746	negative regulation of Notch signaling pathway	0.006051773313375254	0.006051773313375254	+1	EGFR,FBXW7,AKT1
GO:0090504	epiboly	0.006051773313375254	0.006051773313375254	+1	PTEN,ARHGAP35,MTOR
GO:0007423	sensory organ development	0.006051773313375254	0.006051773313375254	+1	NF1,GATA3,SOX9,WT1,PDGFRA,FGFR2,PTPN11
GO:0032526	response to retinoic acid	0.006051773313375254	0.006051773313375254	+1	EPHA3,SOX9,ATM,ASXL1
GO:0035019	somatic stem cell population maintenance	0.006051773313375254	0.006051773313375254	+1	SOX9,SMAD4,SMAD2
GO:0033047	regulation of mitotic sister chromatid segregation	0.006051773313375254	0.006051773313375254	+1	APC,RB1,ATM,ATRX
GO:2001038	regulation of cellular response to drug	0.006051773313375254	0.006051773313375254	+1	NFE2L2,HGF,LRRK2
GO:0030177	positive regulation of Wnt signaling pathway	0.0061223791520526386	0.0061223791520526386	+1	EGFR,LRRK2,FGFR2,TBL1XR1,AXIN2
GO:0008637	apoptotic mitochondrial changes	0.0061223791520526386	0.0061223791520526386	+1	TP53,CDKN2A,AKT1,HGF,ERBB4
GO:0006935	chemotaxis	0.006212377455458856	0.006212377455458856	+1	PIK3CA,PIK3R1,NOTCH1,ARHGAP35,EPHA3,PIK3CG,HGF,KIT,PDGFRA,PTPN11,EGR3
GO:0051236	establishment of RNA localization	0.0062379144487654525	0.0062379144487654525	+1	NPM1,ATM,U2AF1,SETD2,TGFBR2,ATR
GO:0002768	immune response-regulating cell surface receptor signaling pathway	0.006275295699241782	0.006275295699241782	+1	PIK3CA,KRAS,PIK3R1,GATA3,MAP3K1,RUNX1,NRAS,KIT,EP300,CBFB
GO:0042330	taxis	0.006294386214190827	0.006294386214190827	+1	PIK3CA,PIK3R1,NOTCH1,ARHGAP35,EPHA3,PIK3CG,HGF,KIT,PDGFRA,PTPN11,EGR3
GO:1901565	organonitrogen compound catabolic process	0.006299932612558689	0.006299932612558689	+1	PTEN,APC,EGFR,CDKN2A,FBXW7,KEAP1,NFE2L2,CEBPA,CDKN1B,MTOR,TET2,LRRK2,CHEK2,USP9X,TAF1,TBL1XR1,RPL5,SPOP
GO:0072009	nephron epithelium development	0.006358216573279535	0.006358216573279535	+1	GATA3,CTNNB1,SOX9,WT1
GO:0031397	negative regulation of protein ubiquitination	0.006358216573279535	0.006358216573279535	+1	CDKN2A,AKT1,TAF1,RPL5
GO:0055023	positive regulation of cardiac muscle tissue growth	0.006573950795440437	0.006573950795440437	+1	NOTCH1,ERBB4,FGFR2
GO:1904837	beta-catenin-TCF complex assembly	0.006573950795440437	0.006573950795440437	+1	CTNNB1,EP300,AXIN2
GO:0016573	histone acetylation	0.006573950795440437	0.006573950795440437	+1	BRCA1,EP300,SMAD4,BRCA2,SIN3A
GO:0071542	dopaminergic neuron differentiation	0.006573950795440437	0.006573950795440437	+1	CTNNB1,FOXA1,FOXA2
GO:2000826	regulation of heart morphogenesis	0.006573950795440437	0.006573950795440437	+1	NOTCH1,CTNNB1,TGFBR2
GO:2000049	positive regulation of cell-cell adhesion mediated by cadherin	0.006579399787875416	0.006579399787875416	+1	FOXA1,FOXA2
GO:0010259	multicellular organism aging	0.006579399787875416	0.006579399787875416	+1	TP53,LRRK2
GO:0007431	salivary gland development	0.006579399787875416	0.006579399787875416	+1	HGF,FGFR2
GO:0043583	ear development	0.006579399787875416	0.006579399787875416	+1	GATA3,SOX9,FGFR2,PTPN11
GO:1903025	regulation of RNA polymerase II regulatory region sequence-specific DNA binding	0.006579399787875416	0.006579399787875416	+1	TAF1,NSD1
GO:0071493	cellular response to UV-B	0.006579399787875416	0.006579399787875416	+1	STK11,CDKN1A
GO:0062042	regulation of cardiac epithelial to mesenchymal transition	0.006579399787875416	0.006579399787875416	+1	NOTCH1,TGFBR2
GO:0032071	regulation of endodeoxyribonuclease activity	0.006579399787875416	0.006579399787875416	+1	NPM1,AKT1
GO:0061351	neural precursor cell proliferation	0.006579399787875416	0.006579399787875416	+1	NF1,CTNNB1,LRRK2,FGFR2
GO:0140052	cellular response to oxidised low-density lipoprotein particle stimulus	0.006579399787875416	0.006579399787875416	+1	AKT1,TLR4
GO:0060644	mammary gland epithelial cell differentiation	0.006579399787875416	0.006579399787875416	+1	AKT1,ERBB4
GO:0072239	metanephric glomerulus vasculature development	0.006579399787875416	0.006579399787875416	+1	WT1,PDGFRA
GO:1901722	regulation of cell proliferation involved in kidney development	0.006579399787875416	0.006579399787875416	+1	GATA3,WT1
GO:0043374	CD8-positive, alpha-beta T cell differentiation	0.006579399787875416	0.006579399787875416	+1	RUNX1,CBFB
GO:0043068	positive regulation of programmed cell death	0.006579399787875416	0.006579399787875416	+1	TP53,PTEN,APC,NF1,CDKN2A,NOTCH1,FBXW7,CTNNB1,ATM,LRRK2,FOXA1
GO:0036092	phosphatidylinositol-3-phosphate biosynthetic process	0.006579399787875416	0.006579399787875416	+1	PIK3CA,PIK3CG
GO:0090400	stress-induced premature senescence	0.006579399787875416	0.006579399787875416	+1	TP53,CDKN1A
GO:0006975	DNA damage induced protein phosphorylation	0.006579399787875416	0.006579399787875416	+1	ATM,CHEK2
GO:0033599	regulation of mammary gland epithelial cell proliferation	0.006579399787875416	0.006579399787875416	+1	GATA3,BRCA2
GO:0003157	endocardium development	0.006579399787875416	0.006579399787875416	+1	NOTCH1,SOX17
GO:0072497	mesenchymal stem cell differentiation	0.006579399787875416	0.006579399787875416	+1	SOX9,PDGFRA
GO:0034698	response to gonadotropin	0.006579399787875416	0.006579399787875416	+1	NOTCH1,WT1
GO:0051336	regulation of hydrolase activity	0.006593802201365477	0.006593802201365477	+1	TP53,EGFR,NF1,CDKN2A,NPM1,EPHA3,AKT1,HGF,MTOR,LRRK2,KIT,PDGFRA,FGFR2,FGFR3,EZH2
GO:1901214	regulation of neuron death	0.006630359726806437	0.006630359726806437	+1	NF1,FBXW7,CTNNB1,AKT1,TLR4,LRRK2
GO:0060322	head development	0.006634276793711077	0.006634276793711077	+1	PTEN,NF1,CTNNB1,ERBB4,LRRK2,FGFR2,TGFBR2,TAF1,PTPN11
GO:0048660	regulation of smooth muscle cell proliferation	0.006660802411553807	0.006660802411553807	+1	PTEN,CTNNB1,AKT1,CDKN1B,CDKN1A
GO:0007017	microtubule-based process	0.006714795518268552	0.006714795518268552	+1	APC,NAV3,CTNNB1,NPM1,EPHA3,STAG2,BRCA1,CHEK2,SETD2,BRCA2,SMC1A,SMC3,NCOR1
GO:0097191	extrinsic apoptotic signaling pathway	0.006813980585502397	0.006813980585502397	+1	PTEN,AKT1,AR,BRCA1,FGFR3,ACVR1B
GO:1903747	regulation of establishment of protein localization to mitochondrion	0.006888676303884364	0.006888676303884364	+1	TP53,FBXW7,BAP1,LRRK2
GO:0070849	response to epidermal growth factor	0.006948794765569198	0.006948794765569198	+1	EGFR,SOX9,PTPN11
GO:0060675	ureteric bud morphogenesis	0.006948794765569198	0.006948794765569198	+1	GATA3,SOX9,WT1
GO:0036474	cell death in response to hydrogen peroxide	0.006948794765569198	0.006948794765569198	+1	NFE2L2,HGF,LRRK2
GO:0048708	astrocyte differentiation	0.006948794765569198	0.006948794765569198	+1	NF1,NOTCH1,MIR142
GO:0070741	response to interleukin-6	0.006948794765569198	0.006948794765569198	+1	SMAD4,FOXA2,PTPN11
GO:1902893	regulation of pri-miRNA transcription by RNA polymerase II	0.006948794765569198	0.006948794765569198	+1	TP53,SOX9,WT1
GO:0045685	regulation of glial cell differentiation	0.006948794765569198	0.006948794765569198	+1	NF1,NOTCH1,MIR142
GO:0060218	hematopoietic stem cell differentiation	0.006948794765569198	0.006948794765569198	+1	GATA3,RUNX1,CBFB
GO:2000142	regulation of DNA-templated transcription, initiation	0.006948794765569198	0.006948794765569198	+1	TP53,CTNNB1,TAF1
GO:0032102	negative regulation of response to external stimulus	0.006948794765569198	0.006948794765569198	+1	PTEN,GATA3,RB1,NOTCH1,EPPK1,CDKN1B,PDGFRA,CDKN1A
GO:0033144	negative regulation of intracellular steroid hormone receptor signaling pathway	0.006948794765569198	0.006948794765569198	+1	CRIPAK,BRCA1,NCOR1
GO:1902116	negative regulation of organelle assembly	0.006948794765569198	0.006948794765569198	+1	BRCA1,LRRK2,SMAD4
GO:0048659	smooth muscle cell proliferation	0.007079378021958087	0.007079378021958087	+1	PTEN,CTNNB1,AKT1,CDKN1B,CDKN1A
GO:1903322	positive regulation of protein modification by small protein conjugation or removal	0.007079378021958087	0.007079378021958087	+1	PTEN,CDKN2A,FBXW7,BRCA1,LRRK2
GO:0051494	negative regulation of cytoskeleton organization	0.007079378021958087	0.007079378021958087	+1	APC,NAV3,NPM1,BRCA1,SMAD4
GO:0018393	internal peptidyl-lysine acetylation	0.007079378021958087	0.007079378021958087	+1	BRCA1,EP300,SMAD4,BRCA2,SIN3A
GO:0001816	cytokine production	0.0071527268059912085	0.0071527268059912085	+1	NAV3,GATA3,CTNNB1,RUNX1,PIK3CG,TLR4,BRCA1,KIT,SETD2,EP300,SMAD4,PTPN11
GO:1904659	glucose transmembrane transport	0.007155953789309036	0.007155953789309036	+1	PIK3R1,AKT1,BRAF,PTPN11
GO:0006282	regulation of DNA repair	0.0073406324836567454	0.0073406324836567454	+1	EGFR,BRCA1,POLQ,SETD2,AXIN2
GO:0006302	double-strand break repair	0.007495141487619114	0.007495141487619114	+1	ATM,BRCA1,POLQ,CHEK2,SETD2,BRCA2,RAD21
GO:0007368	determination of left/right symmetry	0.007529125910433365	0.007529125910433365	+1	NOTCH1,TGFBR2,SOX17,SMAD2
GO:0046634	regulation of alpha-beta T cell activation	0.007529125910433365	0.007529125910433365	+1	RUNX1,TGFBR2,CBFB,MAPK8IP1
GO:0031648	protein destabilization	0.007543887757714827	0.007543887757714827	+1	CDKN2A,EP300,SOX17
GO:0045862	positive regulation of proteolysis	0.007597262712345183	0.007597262712345183	+1	PTEN,CDKN2A,FBXW7,KEAP1,NFE2L2,CEBPA,LRRK2,TAF1
GO:0007162	negative regulation of cell adhesion	0.007648000451283349	0.007648000451283349	+1	PTEN,CDKN2A,NOTCH1,CDH1,RUNX1,AKT1,CBFB
GO:2001234	negative regulation of apoptotic signaling pathway	0.007733996077566011	0.007733996077566011	+1	NFE2L2,AKT1,AR,HGF,BRCA1,LRRK2
GO:0120036	plasma membrane bounded cell projection organization	0.007791244893205455	0.007791244893205455	+1	PIK3CA,PTEN,APC,NAV3,PIK3R1,RB1,NOTCH1,CTNNB1,ARHGAP35,EPHA3,AKT1,LRRK2,KIT,EP300,FGFR2,USP9X,PPP2R1A,PTPN11
GO:1901575	organic substance catabolic process	0.007791244893205455	0.007791244893205455	+1	PTEN,APC,EGFR,CDKN2A,FBXW7,KEAP1,NFE2L2,NPM1,IDH1,CEBPA,AKT1,ATM,CDKN1B,MTOR,TET2,LRRK2,CHEK2,USP9X,TAF1,PPP2R1A,TBL1XR1,NCOR1,RPL5,SPOP,AXIN2
GO:0045619	regulation of lymphocyte differentiation	0.007837915662305591	0.007837915662305591	+1	CDKN2A,GATA3,RUNX1,TGFBR2,CBFB
GO:0090090	negative regulation of canonical Wnt signaling pathway	0.007837915662305591	0.007837915662305591	+1	APC,STK11,SOX9,SOX17,AXIN2
GO:0006334	nucleosome assembly	0.007837915662305591	0.007837915662305591	+1	NPM1,SOX9,ATRX,HIST1H2BD,H3F3C
GO:2000146	negative regulation of cell motility	0.00786190244670258	0.00786190244670258	+1	PTEN,NAV3,NF1,GATA3,NOTCH1,CDH1,AKT1,EPPK1
GO:0046822	regulation of nucleocytoplasmic transport	0.00786190244670258	0.00786190244670258	+1	TP53,PIK3R1,CDH1,SETD2
GO:0035520	monoubiquitinated protein deubiquitination	0.00804945364026887	0.00804945364026887	+1	BAP1,ASXL1
GO:1903800	positive regulation of production of miRNAs involved in gene silencing by miRNA	0.00804945364026887	0.00804945364026887	+1	TP53,EGFR
GO:0072079	nephron tubule formation	0.00804945364026887	0.00804945364026887	+1	GATA3,SOX9
GO:0048557	embryonic digestive tract morphogenesis	0.00804945364026887	0.00804945364026887	+1	PDGFRA,FGFR2
GO:1905939	regulation of gonad development	0.00804945364026887	0.00804945364026887	+1	SOX9,WT1
GO:0002328	pro-B cell differentiation	0.00804945364026887	0.00804945364026887	+1	NOTCH1,FLT3
GO:0021954	central nervous system neuron development	0.008057844098190615	0.008057844098190615	+1	PTEN,ARHGAP35,FGFR2
GO:0072171	mesonephric tubule morphogenesis	0.008057844098190615	0.008057844098190615	+1	GATA3,SOX9,WT1
GO:0046329	negative regulation of JNK cascade	0.008057844098190615	0.008057844098190615	+1	MAPK8IP1,MECOM,NCOR1
GO:0036003	positive regulation of transcription from RNA polymerase II promoter in response to stress	0.008057844098190615	0.008057844098190615	+1	TP53,NOTCH1,NFE2L2
GO:0045661	regulation of myoblast differentiation	0.008057844098190615	0.008057844098190615	+1	NOTCH1,TBX3,SOX9
GO:0045581	negative regulation of T cell differentiation	0.008057844098190615	0.008057844098190615	+1	CDKN2A,RUNX1,CBFB
GO:0030509	BMP signaling pathway	0.008057844098190615	0.008057844098190615	+1	NOTCH1,SMAD4,USP9X,ACVR2A,SMAD2
GO:0003197	endocardial cushion development	0.008057844098190615	0.008057844098190615	+1	NOTCH1,SOX9,TGFBR2
GO:1901031	regulation of response to reactive oxygen species	0.008057844098190615	0.008057844098190615	+1	NFE2L2,HGF,LRRK2
GO:0051603	proteolysis involved in cellular protein catabolic process	0.008111000824060341	0.008111000824060341	+1	PTEN,CDKN2A,FBXW7,KEAP1,NFE2L2,CEBPA,LRRK2,USP9X,TAF1,TBL1XR1,RPL5,SPOP
GO:1905269	positive regulation of chromatin organization	0.008156918322400241	0.008156918322400241	+1	CTNNB1,BRCA1,SMAD4,SIN3A
GO:0048812	neuron projection morphogenesis	0.008253387559325845	0.008253387559325845	+1	PIK3CA,PTEN,PIK3R1,CTNNB1,ARHGAP35,EPHA3,LRRK2,FGFR2,USP9X,PTPN11
GO:0006475	internal protein amino acid acetylation	0.008286487046276316	0.008286487046276316	+1	BRCA1,EP300,SMAD4,BRCA2,SIN3A
GO:0007596	blood coagulation	0.008560660511229034	0.008560660511229034	+1	PIK3CA,PIK3R1,GATA3,PIK3CG,TLR4,PDGFRA,FOXA2,PTPN11
GO:0031331	positive regulation of cellular catabolic process	0.008560660511229034	0.008560660511229034	+1	PTEN,FBXW7,KEAP1,NFE2L2,STK11,CEBPA,LRRK2,TAF1
GO:1902850	microtubule cytoskeleton organization involved in mitosis	0.008568344279117936	0.008568344279117936	+1	STAG2,CHEK2,SETD2,SMC1A,SMC3
GO:0018394	peptidyl-lysine acetylation	0.008568344279117936	0.008568344279117936	+1	BRCA1,EP300,SMAD4,BRCA2,SIN3A
GO:0030030	cell projection organization	0.008617655649270405	0.008617655649270405	+1	PIK3CA,PTEN,APC,NAV3,PIK3R1,RB1,NOTCH1,CTNNB1,ARHGAP35,EPHA3,AKT1,LRRK2,KIT,EP300,FGFR2,USP9X,PPP2R1A,PTPN11
GO:0032924	activin receptor signaling pathway	0.008698154917929099	0.008698154917929099	+1	ACVR1B,ACVR2A,SMAD2
GO:0046638	positive regulation of alpha-beta T cell differentiation	0.008698154917929099	0.008698154917929099	+1	RUNX1,TGFBR2,CBFB
GO:0051960	regulation of nervous system development	0.008716186248100253	0.008716186248100253	+1	PTEN,NF1,NOTCH1,CTNNB1,ARHGAP35,EPHA3,AKT1,SOX9,LRRK2,EP300,MIR142
GO:0042063	gliogenesis	0.008848403930097908	0.008848403930097908	+1	PTEN,NF1,NOTCH1,SOX9,MIR142
GO:1900180	regulation of protein localization to nucleus	0.008943872361017489	0.008943872361017489	+1	PIK3R1,CDH1,AKT1,SIN3A
GO:0006644	phospholipid metabolic process	0.009062197640208408	0.009062197640208408	+1	PIK3CA,PTEN,PIK3R1,FLT3,IDH1,PIK3CG,KIT,PDGFRA,FGFR3
GO:0070997	neuron death	0.009159246577037672	0.009159246577037672	+1	NF1,FBXW7,CTNNB1,AKT1,TLR4,LRRK2
GO:0007599	hemostasis	0.009201686112476095	0.009201686112476095	+1	PIK3CA,PIK3R1,GATA3,PIK3CG,TLR4,PDGFRA,FOXA2,PTPN11
GO:0050817	coagulation	0.009364456771015904	0.009364456771015904	+1	PIK3CA,PIK3R1,GATA3,PIK3CG,TLR4,PDGFRA,FOXA2,PTPN11
GO:0035850	epithelial cell differentiation involved in kidney development	0.009364456771015904	0.009364456771015904	+1	GATA3,CTNNB1,WT1
GO:0055010	ventricular cardiac muscle tissue morphogenesis	0.009364456771015904	0.009364456771015904	+1	NOTCH1,FGFR2,SMAD4
GO:2000177	regulation of neural precursor cell proliferation	0.009364456771015904	0.009364456771015904	+1	NF1,CTNNB1,LRRK2
GO:0060236	regulation of mitotic spindle organization	0.009364456771015904	0.009364456771015904	+1	STAG2,SMC1A,SMC3
GO:0044344	cellular response to fibroblast growth factor stimulus	0.00941797366972637	0.00941797366972637	+1	GATA3,FGFR2,FGFR3,PTPN11,EGR3
GO:0090316	positive regulation of intracellular protein transport	0.00941797366972637	0.00941797366972637	+1	TP53,PIK3R1,FBXW7,CDH1,BAP1
GO:1904667	negative regulation of ubiquitin protein ligase activity	0.009627654950077237	0.009627654950077237	+1	CDKN2A,RPL5
GO:0060443	mammary gland morphogenesis	0.009627654950077237	0.009627654950077237	+1	ELF3,FGFR2
GO:0010452	histone H3-K36 methylation	0.009627654950077237	0.009627654950077237	+1	SETD2,NSD1
GO:0032070	regulation of deoxyribonuclease activity	0.009627654950077237	0.009627654950077237	+1	NPM1,AKT1
GO:0072182	regulation of nephron tubule epithelial cell differentiation	0.009627654950077237	0.009627654950077237	+1	GATA3,CTNNB1
GO:0048711	positive regulation of astrocyte differentiation	0.009627654950077237	0.009627654950077237	+1	NOTCH1,MIR142
GO:0033598	mammary gland epithelial cell proliferation	0.009627654950077237	0.009627654950077237	+1	GATA3,BRCA2
GO:0060911	cardiac cell fate commitment	0.009627654950077237	0.009627654950077237	+1	WT1,SOX17
GO:0033147	negative regulation of intracellular estrogen receptor signaling pathway	0.009627654950077237	0.009627654950077237	+1	CRIPAK,BRCA1
GO:0120039	plasma membrane bounded cell projection morphogenesis	0.009753947712158656	0.009753947712158656	+1	PIK3CA,PTEN,PIK3R1,CTNNB1,ARHGAP35,EPHA3,LRRK2,FGFR2,USP9X,PTPN11
GO:0007409	axonogenesis	0.009814679362533002	0.009814679362533002	+1	PIK3CA,PTEN,PIK3R1,ARHGAP35,EPHA3,FGFR2,USP9X,PTPN11
GO:0048858	cell projection morphogenesis	0.009893003867988885	0.009893003867988885	+1	PIK3CA,PTEN,PIK3R1,CTNNB1,ARHGAP35,EPHA3,LRRK2,FGFR2,USP9X,PTPN11
GO:0061614	pri-miRNA transcription by RNA polymerase II	0.009947845488903864	0.009947845488903864	+1	TP53,SOX9,WT1
GO:0046854	phosphatidylinositol phosphorylation	0.009947845488903864	0.009947845488903864	+1	PIK3CA,PIK3R1,PIK3CG
GO:0060021	roof of mouth development	0.009947845488903864	0.009947845488903864	+1	SMAD4,TGFBR2,SMAD2
GO:0060043	regulation of cardiac muscle cell proliferation	0.009947845488903864	0.009947845488903864	+1	NOTCH1,ERBB4,FGFR2
GO:1904706	negative regulation of vascular smooth muscle cell proliferation	0.009947845488903864	0.009947845488903864	+1	PTEN,CDKN1B,CDKN1A
GO:0071774	response to fibroblast growth factor	0.009947845488903864	0.009947845488903864	+1	GATA3,FGFR2,FGFR3,PTPN11,EGR3
GO:0010823	negative regulation of mitochondrion organization	0.009947845488903864	0.009947845488903864	+1	AKT1,HGF,LRRK2
GO:0032355	response to estradiol	0.009947845488903864	0.009947845488903864	+1	EGFR,CTNNB1,FOXA1
GO:0030278	regulation of ossification	0.009947845488903864	0.009947845488903864	+1	NOTCH1,SOX9,HGF,FGFR2,ACVR2A
GO:0034330	cell junction organization	0.010036859770008816	0.010036859770008816	+1	PTEN,APC,CTNNB1,CDH1,RUNX1,EPHA3,CBFB
GO:0060964	regulation of gene silencing by miRNA	0.010054137408080258	0.010054137408080258	+1	TP53,EGFR,AJUBA,NCOR1
GO:0009855	determination of bilateral symmetry	0.010054137408080258	0.010054137408080258	+1	NOTCH1,TGFBR2,SOX17,SMAD2
GO:0002761	regulation of myeloid leukocyte differentiation	0.010054137408080258	0.010054137408080258	+1	FBXW7,RUNX1,MTOR,TLR4
GO:0009991	response to extracellular stimulus	0.010224750951385312	0.010224750951385312	+1	TP53,ARHGAP35,MTOR,LRRK2,FOXA2,CDKN1A,TAF1
GO:0060560	developmental growth involved in morphogenesis	0.010224750951385312	0.010224750951385312	+1	NOTCH1,CTNNB1,SOX9,FGFR2,USP9X
GO:0042692	muscle cell differentiation	0.010452427881871326	0.010452427881871326	+1	NOTCH1,CTNNB1,WT1,KIT,PDGFRA,FGFR2,SMAD4
GO:0010721	negative regulation of cell development	0.010473847040894766	0.010473847040894766	+1	PTEN,NF1,NOTCH1,FBXW7,SOX9,SMAD4
GO:1901888	regulation of cell junction assembly	0.010474783708478996	0.010474783708478996	+1	PTEN,RUNX1,EPHA3,CBFB
GO:0008645	hexose transmembrane transport	0.010474783708478996	0.010474783708478996	+1	PIK3R1,AKT1,BRAF,PTPN11
GO:0045652	regulation of megakaryocyte differentiation	0.010474783708478996	0.010474783708478996	+1	RUNX1,EP300,CBFB,SIN3A
GO:0009799	specification of symmetry	0.010474783708478996	0.010474783708478996	+1	NOTCH1,TGFBR2,SOX17,SMAD2
GO:0035065	regulation of histone acetylation	0.010593023308556729	0.010593023308556729	+1	BRCA1,SMAD4,SIN3A
GO:0008631	intrinsic apoptotic signaling pathway in response to oxidative stress	0.010593023308556729	0.010593023308556729	+1	FBXW7,NFE2L2,AKT1
GO:0072091	regulation of stem cell proliferation	0.010593023308556729	0.010593023308556729	+1	NF1,CTNNB1,LRRK2
GO:0038202	TORC1 signaling	0.010593023308556729	0.010593023308556729	+1	STK11,ATM,MTOR
GO:0003229	ventricular cardiac muscle tissue development	0.010593023308556729	0.010593023308556729	+1	NOTCH1,FGFR2,SMAD4
GO:0072078	nephron tubule morphogenesis	0.010593023308556729	0.010593023308556729	+1	GATA3,SOX9,WT1
GO:0072655	establishment of protein localization to mitochondrion	0.01082449706029614	0.01082449706029614	+1	TP53,FBXW7,BAP1,AKT1,LRRK2
GO:0044248	cellular catabolic process	0.010829241463614993	0.010829241463614993	+1	TP53,PIK3CA,PTEN,CDKN2A,FBXW7,KEAP1,NFE2L2,NPM1,IDH1,STK11,CEBPA,AKT1,ATM,HGF,MTOR,TET2,LRRK2,CHEK2,EP300,USP9X,TAF1,PPP2R1A,TBL1XR1,RPL5,SPOP,AXIN2
GO:1901989	positive regulation of cell cycle phase transition	0.010896080162685721	0.010896080162685721	+1	RB1,NPM1,CCND1,EZH2
GO:0006396	RNA processing	0.01114276541575554	0.01114276541575554	+1	TP53,EGFR,PIK3R1,WT1,PRX,U2AF1,SF3B1,PPP2R1A,CDK12,NCOR1,RPL5,SMAD2,ERCC2,PCBP1
GO:2001242	regulation of intrinsic apoptotic signaling pathway	0.011150158023616338	0.011150158023616338	+1	TP53,FBXW7,NFE2L2,AKT1,LRRK2
GO:0007265	Ras protein signal transduction	0.011150158023616338	0.011150158023616338	+1	TP53,KRAS,NF1,CDKN2A,RB1,NOTCH1,NRAS,CDKN1A
GO:0030325	adrenal gland development	0.011189562146797656	0.011189562146797656	+1	NF1,WT1
GO:0060966	regulation of gene silencing by RNA	0.011189562146797656	0.011189562146797656	+1	TP53,EGFR,AJUBA,NCOR1
GO:0035272	exocrine system development	0.011189562146797656	0.011189562146797656	+1	HGF,FGFR2
GO:0032990	cell part morphogenesis	0.011189562146797656	0.011189562146797656	+1	PIK3CA,PTEN,PIK3R1,CTNNB1,ARHGAP35,EPHA3,LRRK2,FGFR2,USP9X,PTPN11
GO:1903209	positive regulation of oxidative stress-induced cell death	0.011189562146797656	0.011189562146797656	+1	FBXW7,TLR4
GO:0007183	SMAD protein complex assembly	0.011189562146797656	0.011189562146797656	+1	SMAD4,SMAD2
GO:0010826	negative regulation of centrosome duplication	0.011189562146797656	0.011189562146797656	+1	NPM1,BRCA1
GO:0015749	monosaccharide transmembrane transport	0.011189562146797656	0.011189562146797656	+1	PIK3R1,AKT1,BRAF,PTPN11
GO:0046324	regulation of glucose import	0.011189562146797656	0.011189562146797656	+1	PIK3R1,AKT1,PTPN11
GO:0034219	carbohydrate transmembrane transport	0.011189562146797656	0.011189562146797656	+1	PIK3R1,AKT1,BRAF,PTPN11
GO:0060147	regulation of posttranscriptional gene silencing	0.011189562146797656	0.011189562146797656	+1	TP53,EGFR,AJUBA,NCOR1
GO:0060039	pericardium development	0.011189562146797656	0.011189562146797656	+1	NOTCH1,WT1
GO:2000136	regulation of cell proliferation involved in heart morphogenesis	0.011189562146797656	0.011189562146797656	+1	NOTCH1,CTNNB1
GO:0030889	negative regulation of B cell proliferation	0.011189562146797656	0.011189562146797656	+1	CDKN2A,ATM
GO:0072350	tricarboxylic acid metabolic process	0.011189562146797656	0.011189562146797656	+1	IDH1,IDH2
GO:0003401	axis elongation	0.011189562146797656	0.011189562146797656	+1	SOX9,FGFR2
GO:0031645	negative regulation of neurological system process	0.011189562146797656	0.011189562146797656	+1	PTEN,LRRK2
GO:0001947	heart looping	0.011189562146797656	0.011189562146797656	+1	NOTCH1,TGFBR2,SOX17
GO:0090224	regulation of spindle organization	0.011189562146797656	0.011189562146797656	+1	STAG2,SMC1A,SMC3
GO:0033048	negative regulation of mitotic sister chromatid segregation	0.011189562146797656	0.011189562146797656	+1	APC,ATM,ATRX
GO:0050878	regulation of body fluid levels	0.011616303437828124	0.011616303437828124	+1	PIK3CA,PIK3R1,GATA3,PIK3CG,ERBB4,TLR4,PDGFRA,FOXA2,PTPN11
GO:0070585	protein localization to mitochondrion	0.011667477317781387	0.011667477317781387	+1	TP53,FBXW7,BAP1,AKT1,LRRK2
GO:0000018	regulation of DNA recombination	0.011667477317781387	0.011667477317781387	+1	POLQ,HIST1H1C,SETD2,ERCC2
GO:0006368	transcription elongation from RNA polymerase II promoter	0.011667477317781387	0.011667477317781387	+1	PBRM1,SETD2,CDK12,ERCC2
GO:0009266	response to temperature stimulus	0.011667477317781387	0.011667477317781387	+1	AKT1,ATM,MTOR,EP300,ATR
GO:0046651	lymphocyte proliferation	0.011858136171705703	0.011858136171705703	+1	CDKN2A,FLT3,PIK3CG,ATM,TGFBR2,MAPK8IP1
GO:0010863	positive regulation of phospholipase C activity	0.01190820904533154	0.01190820904533154	+1	EGFR,KIT,PDGFRA
GO:2000059	negative regulation of ubiquitin-dependent protein catabolic process	0.01190820904533154	0.01190820904533154	+1	CDKN2A,TAF1,RPL5
GO:0061005	cell differentiation involved in kidney development	0.01190820904533154	0.01190820904533154	+1	GATA3,CTNNB1,WT1
GO:0045670	regulation of osteoclast differentiation	0.01190820904533154	0.01190820904533154	+1	FBXW7,MTOR,TLR4
GO:0072028	nephron morphogenesis	0.01190820904533154	0.01190820904533154	+1	GATA3,SOX9,WT1
GO:0072088	nephron epithelium morphogenesis	0.01190820904533154	0.01190820904533154	+1	GATA3,SOX9,WT1
GO:0055025	positive regulation of cardiac muscle tissue development	0.01190820904533154	0.01190820904533154	+1	NOTCH1,ERBB4,FGFR2
GO:0042752	regulation of circadian rhythm	0.012113708419064412	0.012113708419064412	+1	TP53,USP9X,SIN3A,EZH2
GO:0051271	negative regulation of cellular component movement	0.012131143244299352	0.012131143244299352	+1	PTEN,NAV3,NF1,GATA3,NOTCH1,CDH1,AKT1,EPPK1
GO:0032943	mononuclear cell proliferation	0.012387386696777353	0.012387386696777353	+1	CDKN2A,FLT3,PIK3CG,ATM,TGFBR2,MAPK8IP1
GO:0045667	regulation of osteoblast differentiation	0.012635399315735898	0.012635399315735898	+1	NOTCH1,HGF,FGFR2,ACVR2A
GO:0033046	negative regulation of sister chromatid segregation	0.012660547988077774	0.012660547988077774	+1	APC,ATM,ATRX
GO:0045747	positive regulation of Notch signaling pathway	0.012660547988077774	0.012660547988077774	+1	NOTCH1,ELF3,EP300
GO:0044331	cell-cell adhesion mediated by cadherin	0.012660547988077774	0.012660547988077774	+1	CDH1,FOXA1,FOXA2
GO:0045620	negative regulation of lymphocyte differentiation	0.012660547988077774	0.012660547988077774	+1	CDKN2A,RUNX1,CBFB
GO:0050866	negative regulation of cell activation	0.012660547988077774	0.012660547988077774	+1	CDKN2A,RUNX1,ATM,PDGFRA,CBFB
GO:0060038	cardiac muscle cell proliferation	0.012660547988077774	0.012660547988077774	+1	NOTCH1,ERBB4,FGFR2
GO:0006984	ER-nucleus signaling pathway	0.012660547988077774	0.012660547988077774	+1	TP53,FBXW7,NFE2L2
GO:1903214	regulation of protein targeting to mitochondrion	0.012660547988077774	0.012660547988077774	+1	FBXW7,BAP1,LRRK2
GO:0061333	renal tubule morphogenesis	0.012660547988077774	0.012660547988077774	+1	GATA3,SOX9,WT1
GO:0007351	tripartite regional subdivision	0.012778439371008636	0.012778439371008636	+1	TBX3,WT1
GO:0034088	maintenance of mitotic sister chromatid cohesion	0.012778439371008636	0.012778439371008636	+1	RB1,ATRX
GO:0007413	axonal fasciculation	0.012778439371008636	0.012778439371008636	+1	ARHGAP35,EPHA3
GO:0098751	bone cell development	0.012778439371008636	0.012778439371008636	+1	FBXW7,KIT
GO:0033262	regulation of nuclear cell cycle DNA replication	0.012778439371008636	0.012778439371008636	+1	ATRX,CHEK2
GO:0080182	histone H3-K4 trimethylation	0.012778439371008636	0.012778439371008636	+1	TET2,HIST1H1C
GO:0072224	metanephric glomerulus development	0.012778439371008636	0.012778439371008636	+1	WT1,PDGFRA
GO:0007350	blastoderm segmentation	0.012778439371008636	0.012778439371008636	+1	TBX3,WT1
GO:0070734	histone H3-K27 methylation	0.012778439371008636	0.012778439371008636	+1	HIST1H1C,EZH2
GO:0045686	negative regulation of glial cell differentiation	0.012778439371008636	0.012778439371008636	+1	NF1,NOTCH1
GO:0061323	cell proliferation involved in heart morphogenesis	0.012778439371008636	0.012778439371008636	+1	NOTCH1,CTNNB1
GO:0021988	olfactory lobe development	0.012778439371008636	0.012778439371008636	+1	ERBB4,LRRK2
GO:0072160	nephron tubule epithelial cell differentiation	0.012778439371008636	0.012778439371008636	+1	GATA3,CTNNB1
GO:0008595	anterior/posterior axis specification, embryo	0.012778439371008636	0.012778439371008636	+1	TBX3,WT1
GO:0048713	regulation of oligodendrocyte differentiation	0.012778439371008636	0.012778439371008636	+1	NF1,NOTCH1
GO:0034086	maintenance of sister chromatid cohesion	0.012778439371008636	0.012778439371008636	+1	RB1,ATRX
GO:0003198	epithelial to mesenchymal transition involved in endocardial cushion formation	0.012778439371008636	0.012778439371008636	+1	NOTCH1,TGFBR2
GO:0035162	embryonic hemopoiesis	0.012778439371008636	0.012778439371008636	+1	KIT,TGFBR2
GO:0035067	negative regulation of histone acetylation	0.012778439371008636	0.012778439371008636	+1	BRCA1,SIN3A
GO:0106030	neuron projection fasciculation	0.012778439371008636	0.012778439371008636	+1	ARHGAP35,EPHA3
GO:0021772	olfactory bulb development	0.012778439371008636	0.012778439371008636	+1	ERBB4,LRRK2
GO:0045995	regulation of embryonic development	0.012864243140513636	0.012864243140513636	+1	GATA3,CTNNB1,FOXA2,SOX17
GO:0061564	axon development	0.012944317131943989	0.012944317131943989	+1	PIK3CA,PTEN,PIK3R1,ARHGAP35,EPHA3,FGFR2,USP9X,PTPN11
GO:0051099	positive regulation of binding	0.013192323861669502	0.013192323861669502	+1	GATA3,RB1,CTNNB1,LRRK2,TAF1
GO:0022408	negative regulation of cell-cell adhesion	0.013192323861669502	0.013192323861669502	+1	CDKN2A,CDH1,RUNX1,AKT1,CBFB
GO:0051147	regulation of muscle cell differentiation	0.013192323861669502	0.013192323861669502	+1	NOTCH1,CTNNB1,KIT,FGFR2,SMAD4
GO:2000756	regulation of peptidyl-lysine acetylation	0.013246592381207263	0.013246592381207263	+1	BRCA1,SMAD4,SIN3A
GO:0090199	regulation of release of cytochrome c from mitochondria	0.013246592381207263	0.013246592381207263	+1	TP53,AKT1,HGF
GO:0051985	negative regulation of chromosome segregation	0.013246592381207263	0.013246592381207263	+1	APC,ATM,ATRX
GO:1900274	regulation of phospholipase C activity	0.013246592381207263	0.013246592381207263	+1	EGFR,KIT,PDGFRA
GO:0034605	cellular response to heat	0.013336032348283448	0.013336032348283448	+1	ATM,MTOR,EP300,ATR
GO:0002764	immune response-regulating signaling pathway	0.013473716196645384	0.013473716196645384	+1	PIK3CA,KRAS,PIK3R1,GATA3,MAP3K1,RUNX1,NRAS,TLR4,KIT,EP300,CBFB
GO:0030900	forebrain development	0.01352669231735509	0.01352669231735509	+1	PTEN,NF1,ERBB4,LRRK2,FGFR2
GO:0045444	fat cell differentiation	0.01352669231735509	0.01352669231735509	+1	GATA3,CEBPA,AKT1,EP300,ASXL1
GO:0006403	RNA localization	0.01355249518097624	0.01355249518097624	+1	NPM1,ATM,U2AF1,SETD2,TGFBR2,ATR
GO:0040013	negative regulation of locomotion	0.013782097831502239	0.013782097831502239	+1	PTEN,NAV3,NF1,GATA3,NOTCH1,CDH1,AKT1,EPPK1
GO:0061371	determination of heart left/right asymmetry	0.014069420847683575	0.014069420847683575	+1	NOTCH1,TGFBR2,SOX17
GO:0003143	embryonic heart tube morphogenesis	0.014069420847683575	0.014069420847683575	+1	NOTCH1,TGFBR2,SOX17
GO:0060079	excitatory postsynaptic potential	0.014069420847683575	0.014069420847683575	+1	PTEN,AKT1,LRRK2
GO:0055021	regulation of cardiac muscle tissue growth	0.014069420847683575	0.014069420847683575	+1	NOTCH1,ERBB4,FGFR2
GO:0051345	positive regulation of hydrolase activity	0.014087487387986876	0.014087487387986876	+1	EGFR,NF1,CDKN2A,AKT1,MTOR,KIT,PDGFRA,FGFR2,FGFR3,EZH2
GO:1901653	cellular response to peptide	0.014149797530512945	0.014149797530512945	+1	TP53,PIK3CA,APC,PIK3R1,AKT1,TLR4,PTPN11
GO:0031347	regulation of defense response	0.014275789755212322	0.014275789755212322	+1	KRAS,GATA3,RB1,MAP3K1,NRAS,CEBPA,TLR4,EP300,SIN3A,PTPN11,MIR142
GO:0071236	cellular response to antibiotic	0.014355658582834815	0.014355658582834815	+1	TP53,NFE2L2,HGF,LRRK2
GO:0008643	carbohydrate transport	0.014355658582834815	0.014355658582834815	+1	PIK3R1,AKT1,BRAF,PTPN11
GO:0002320	lymphoid progenitor cell differentiation	0.014611567263856122	0.014611567263856122	+1	NOTCH1,FLT3
GO:2000757	negative regulation of peptidyl-lysine acetylation	0.014611567263856122	0.014611567263856122	+1	BRCA1,SIN3A
GO:1900409	positive regulation of cellular response to oxidative stress	0.014611567263856122	0.014611567263856122	+1	FBXW7,TLR4
GO:0060231	mesenchymal to epithelial transition	0.014611567263856122	0.014611567263856122	+1	GATA3,WT1
GO:0090185	negative regulation of kidney development	0.014611567263856122	0.014611567263856122	+1	GATA3,WT1
GO:1905331	negative regulation of morphogenesis of an epithelium	0.014611567263856122	0.014611567263856122	+1	PTEN,GATA3
GO:0048385	regulation of retinoic acid receptor signaling pathway	0.014611567263856122	0.014611567263856122	+1	ASXL1,EZH2
GO:0072273	metanephric nephron morphogenesis	0.014611567263856122	0.014611567263856122	+1	SOX9,WT1
GO:0046606	negative regulation of centrosome cycle	0.014611567263856122	0.014611567263856122	+1	NPM1,BRCA1
GO:2000696	regulation of epithelial cell differentiation involved in kidney development	0.014611567263856122	0.014611567263856122	+1	GATA3,CTNNB1
GO:0046323	glucose import	0.014833224003307792	0.014833224003307792	+1	PIK3R1,AKT1,PTPN11
GO:0043030	regulation of macrophage activation	0.014833224003307792	0.014833224003307792	+1	CEBPA,TLR4,MIR142
GO:0030178	negative regulation of Wnt signaling pathway	0.015012510410361718	0.015012510410361718	+1	APC,STK11,SOX9,SOX17,AXIN2
GO:0000904	cell morphogenesis involved in differentiation	0.01535444543034857	0.01535444543034857	+1	PIK3CA,PTEN,PIK3R1,RB1,ARHGAP35,EPHA3,LRRK2,FGFR2,USP9X,PTPN11
GO:0043065	positive regulation of apoptotic process	0.015561826274982014	0.015561826274982014	+1	TP53,PTEN,APC,NF1,CDKN2A,NOTCH1,FBXW7,CTNNB1,ATM,FOXA1
GO:0044089	positive regulation of cellular component biogenesis	0.015727057759738892	0.015727057759738892	+1	TP53,APC,NAV3,ARHGAP35,AJUBA,ATM,TLR4,ATR,ERCC2
GO:0046824	positive regulation of nucleocytoplasmic transport	0.01574048900771348	0.01574048900771348	+1	TP53,PIK3R1,CDH1
GO:0070303	negative regulation of stress-activated protein kinase signaling cascade	0.01574048900771348	0.01574048900771348	+1	MAPK8IP1,MECOM,NCOR1
GO:0032873	negative regulation of stress-activated MAPK cascade	0.01574048900771348	0.01574048900771348	+1	MAPK8IP1,MECOM,NCOR1
GO:2001022	positive regulation of response to DNA damage stimulus	0.01595600400315977	0.01595600400315977	+1	EGFR,ATM,BRCA1,ATR
GO:2000241	regulation of reproductive process	0.01595600400315977	0.01595600400315977	+1	SOX9,WT1,FGFR2,ACVR1B
GO:0016202	regulation of striated muscle tissue development	0.01595600400315977	0.01595600400315977	+1	NOTCH1,ERBB4,FGFR2,SMAD4
GO:0014706	striated muscle tissue development	0.016048652700354372	0.016048652700354372	+1	NOTCH1,WT1,ERBB4,PDGFRA,FGFR2,SMAD4
GO:0120161	regulation of cold-induced thermogenesis	0.016256386453453835	0.016256386453453835	+1	APC,RB1,NOTCH1,STK11,TLR4
GO:0000070	mitotic sister chromatid segregation	0.016256386453453835	0.016256386453453835	+1	APC,RB1,ATM,ATRX,SMC1A
GO:0106106	cold-induced thermogenesis	0.016256386453453835	0.016256386453453835	+1	APC,RB1,NOTCH1,STK11,TLR4
GO:0043388	positive regulation of DNA binding	0.016506046084691285	0.016506046084691285	+1	GATA3,RB1,CTNNB1
GO:1901861	regulation of muscle tissue development	0.016506046084691285	0.016506046084691285	+1	NOTCH1,ERBB4,FGFR2,SMAD4
GO:0072425	signal transduction involved in G2 DNA damage checkpoint	0.016506046084691285	0.016506046084691285	+1	ATM,BRCA1
GO:0033260	nuclear DNA replication	0.016506046084691285	0.016506046084691285	+1	ATRX,CHEK2,BRCA2
GO:2000191	regulation of fatty acid transport	0.016506046084691285	0.016506046084691285	+1	AKT1,NCOR1
GO:0007530	sex determination	0.016506046084691285	0.016506046084691285	+1	SOX9,WT1
GO:0006103	2-oxoglutarate metabolic process	0.016506046084691285	0.016506046084691285	+1	IDH1,IDH2
GO:0038092	nodal signaling pathway	0.016506046084691285	0.016506046084691285	+1	ACVR1B,SMAD2
GO:0071300	cellular response to retinoic acid	0.016506046084691285	0.016506046084691285	+1	EPHA3,SOX9,ATM
GO:0010224	response to UV-B	0.016506046084691285	0.016506046084691285	+1	STK11,CDKN1A
GO:0043517	positive regulation of DNA damage response, signal transduction by p53 class mediator	0.016506046084691285	0.016506046084691285	+1	ATM,ATR
GO:0035313	wound healing, spreading of epidermal cells	0.016506046084691285	0.016506046084691285	+1	PTEN,MTOR
GO:0006978	DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator	0.016506046084691285	0.016506046084691285	+1	TP53,BRCA1
GO:2000047	regulation of cell-cell adhesion mediated by cadherin	0.016506046084691285	0.016506046084691285	+1	FOXA1,FOXA2
GO:0009952	anterior/posterior pattern specification	0.016506046084691285	0.016506046084691285	+1	TBX3,WT1,FOXA2,SMAD2
GO:0046635	positive regulation of alpha-beta T cell activation	0.016506046084691285	0.016506046084691285	+1	RUNX1,TGFBR2,CBFB
GO:0072207	metanephric epithelium development	0.016506046084691285	0.016506046084691285	+1	SOX9,WT1
GO:0072111	cell proliferation involved in kidney development	0.016506046084691285	0.016506046084691285	+1	GATA3,WT1
GO:0006354	DNA-templated transcription, elongation	0.01695231241069205	0.01695231241069205	+1	PBRM1,SETD2,CDK12,ERCC2
GO:0021537	telencephalon development	0.01695231241069205	0.01695231241069205	+1	PTEN,NF1,ERBB4,LRRK2
GO:0046834	lipid phosphorylation	0.017440712768676713	0.017440712768676713	+1	PIK3CA,PIK3R1,PIK3CG
GO:0060759	regulation of response to cytokine stimulus	0.017440712768676713	0.017440712768676713	+1	RUNX1,TLR4,CBFB,PTPN11,LIFR
GO:0001819	positive regulation of cytokine production	0.017442182230891397	0.017442182230891397	+1	GATA3,CTNNB1,RUNX1,TLR4,BRCA1,SETD2,EP300,PTPN11
GO:0048639	positive regulation of developmental growth	0.017572112071659565	0.017572112071659565	+1	NOTCH1,WT1,ERBB4,FGFR2
GO:0010038	response to metal ion	0.01765311572005918	0.01765311572005918	+1	EGFR,CDH1,AKT1,BRAF,CDKN1B,LRRK2
GO:1990845	adaptive thermogenesis	0.01789339950245376	0.01789339950245376	+1	APC,RB1,NOTCH1,STK11,TLR4
GO:0046631	alpha-beta T cell activation	0.018205679209489994	0.018205679209489994	+1	RUNX1,TGFBR2,CBFB,MAPK8IP1
GO:2000278	regulation of DNA biosynthetic process	0.018205679209489994	0.018205679209489994	+1	TP53,ATM,HGF,ATR
GO:0120192	tight junction assembly	0.018331108692972827	0.018331108692972827	+1	APC,RUNX1,CBFB
GO:0046637	regulation of alpha-beta T cell differentiation	0.018331108692972827	0.018331108692972827	+1	RUNX1,TGFBR2,CBFB
GO:0070830	bicellular tight junction assembly	0.018331108692972827	0.018331108692972827	+1	APC,RUNX1,CBFB
GO:0030071	regulation of mitotic metaphase/anaphase transition	0.018331108692972827	0.018331108692972827	+1	APC,RB1,ATM
GO:0035050	embryonic heart tube development	0.018331108692972827	0.018331108692972827	+1	NOTCH1,TGFBR2,SOX17
GO:2000243	positive regulation of reproductive process	0.018331108692972827	0.018331108692972827	+1	SOX9,WT1,ACVR1B
GO:0045839	negative regulation of mitotic nuclear division	0.018331108692972827	0.018331108692972827	+1	APC,ATM,ATRX
GO:0051570	regulation of histone H3-K9 methylation	0.018511448502251462	0.018511448502251462	+1	ATRX,BRCA1
GO:0090201	negative regulation of release of cytochrome c from mitochondria	0.018511448502251462	0.018511448502251462	+1	AKT1,HGF
GO:1903203	regulation of oxidative stress-induced neuron death	0.018511448502251462	0.018511448502251462	+1	FBXW7,TLR4
GO:0071850	mitotic cell cycle arrest	0.018511448502251462	0.018511448502251462	+1	CDKN1B,CDKN1A
GO:0007252	I-kappaB phosphorylation	0.018511448502251462	0.018511448502251462	+1	AKT1,TLR4
GO:0043371	negative regulation of CD4-positive, alpha-beta T cell differentiation	0.018511448502251462	0.018511448502251462	+1	RUNX1,CBFB
GO:0048103	somatic stem cell division	0.018511448502251462	0.018511448502251462	+1	CDKN2A,FGFR2
GO:0036475	neuron death in response to oxidative stress	0.018511448502251462	0.018511448502251462	+1	FBXW7,TLR4
GO:0035635	entry of bacterium into host cell	0.018511448502251462	0.018511448502251462	+1	CTNNB1,CDH1
GO:0042772	DNA damage response, signal transduction resulting in transcription	0.018511448502251462	0.018511448502251462	+1	TP53,BRCA1
GO:0016584	nucleosome positioning	0.018511448502251462	0.018511448502251462	+1	CTCF,HIST1H1C
GO:0045992	negative regulation of embryonic development	0.018511448502251462	0.018511448502251462	+1	GATA3,CTNNB1
GO:1902884	positive regulation of response to oxidative stress	0.018511448502251462	0.018511448502251462	+1	FBXW7,TLR4
GO:0003002	regionalization	0.018563484450341478	0.018563484450341478	+1	TBX3,WT1,FGFR2,FOXA2,SMAD2
GO:0048634	regulation of muscle organ development	0.018563484450341478	0.018563484450341478	+1	NOTCH1,ERBB4,FGFR2,SMAD4
GO:1902107	positive regulation of leukocyte differentiation	0.018563484450341478	0.018563484450341478	+1	GATA3,RUNX1,TGFBR2,CBFB
GO:0001649	osteoblast differentiation	0.018563484450341478	0.018563484450341478	+1	NF1,NOTCH1,HGF,FGFR2,ACVR2A
GO:0007264	small GTPase mediated signal transduction	0.018816809972761153	0.018816809972761153	+1	TP53,KRAS,NF1,CDKN2A,RB1,NOTCH1,ARHGAP35,NRAS,CDKN1A
GO:0051223	regulation of protein transport	0.018965637755709308	0.018965637755709308	+1	TP53,PIK3R1,GATA3,FBXW7,CDH1,BAP1,TLR4,LRRK2,SETD2,FOXA2
GO:0099565	chemical synaptic transmission, postsynaptic	0.019087582430720344	0.019087582430720344	+1	PTEN,AKT1,LRRK2
GO:2000514	regulation of CD4-positive, alpha-beta T cell activation	0.019087582430720344	0.019087582430720344	+1	RUNX1,TGFBR2,CBFB
GO:1905268	negative regulation of chromatin organization	0.019087582430720344	0.019087582430720344	+1	BRCA1,HIST1H1C,SIN3A
GO:0014855	striated muscle cell proliferation	0.019087582430720344	0.019087582430720344	+1	NOTCH1,ERBB4,FGFR2
GO:1902099	regulation of metaphase/anaphase transition of cell cycle	0.019087582430720344	0.019087582430720344	+1	APC,RB1,ATM
GO:0043433	negative regulation of DNA-binding transcription factor activity	0.01950797362736091	0.01950797362736091	+1	CDKN2A,RB1,KEAP1,FOXA2,TAF1
GO:0030336	negative regulation of cell migration	0.019581529349770546	0.019581529349770546	+1	PTEN,NAV3,NF1,NOTCH1,CDH1,AKT1,EPPK1
GO:0032386	regulation of intracellular transport	0.019581529349770546	0.019581529349770546	+1	TP53,PIK3R1,FBXW7,CDH1,BAP1,LRRK2,SETD2
GO:1903038	negative regulation of leukocyte cell-cell adhesion	0.019805860694134408	0.019805860694134408	+1	CDKN2A,RUNX1,AKT1,CBFB
GO:0001952	regulation of cell-matrix adhesion	0.019805860694134408	0.019805860694134408	+1	PTEN,NF1,CDKN2A,EPHA3
GO:0031398	positive regulation of protein ubiquitination	0.019805860694134408	0.019805860694134408	+1	PTEN,FBXW7,BRCA1,LRRK2
GO:0046890	regulation of lipid biosynthetic process	0.019962380250063676	0.019962380250063676	+1	FBXW7,IDH1,AKT1,MTOR,BRCA1
GO:0035107	appendage morphogenesis	0.020035346885480636	0.020035346885480636	+1	CTNNB1,TBX3,FGFR2
GO:0120193	tight junction organization	0.020035346885480636	0.020035346885480636	+1	APC,RUNX1,CBFB
GO:0032206	positive regulation of telomere maintenance	0.020035346885480636	0.020035346885480636	+1	ATM,ATRX,ATR
GO:0021782	glial cell development	0.020035346885480636	0.020035346885480636	+1	PTEN,NF1,MIR142
GO:0035108	limb morphogenesis	0.020035346885480636	0.020035346885480636	+1	CTNNB1,TBX3,FGFR2
GO:0006473	protein acetylation	0.020405936348296665	0.020405936348296665	+1	BRCA1,EP300,SMAD4,BRCA2,SIN3A
GO:0007051	spindle organization	0.020405936348296665	0.020405936348296665	+1	STAG2,CHEK2,SMC1A,SMC3,NCOR1
GO:0051250	negative regulation of lymphocyte activation	0.020405936348296665	0.020405936348296665	+1	CDKN2A,RUNX1,ATM,CBFB
GO:0045687	positive regulation of glial cell differentiation	0.020435338939664285	0.020435338939664285	+1	NOTCH1,MIR142
GO:0003338	metanephros morphogenesis	0.020435338939664285	0.020435338939664285	+1	SOX9,WT1
GO:2000811	negative regulation of anoikis	0.020435338939664285	0.020435338939664285	+1	PIK3CA,NOTCH1
GO:0010165	response to X-ray	0.020435338939664285	0.020435338939664285	+1	GATA3,ATM
GO:0001569	branching involved in blood vessel morphogenesis	0.020435338939664285	0.020435338939664285	+1	CTNNB1,TGFBR2
GO:0051444	negative regulation of ubiquitin-protein transferase activity	0.020435338939664285	0.020435338939664285	+1	CDKN2A,RPL5
GO:0045116	protein neddylation	0.020435338939664285	0.020435338939664285	+1	CDKN2A,RPL5
GO:0070102	interleukin-6-mediated signaling pathway	0.020435338939664285	0.020435338939664285	+1	SMAD4,PTPN11
GO:0048854	brain morphogenesis	0.020435338939664285	0.020435338939664285	+1	PTEN,NF1
GO:0072012	glomerulus vasculature development	0.020435338939664285	0.020435338939664285	+1	WT1,PDGFRA
GO:0046426	negative regulation of receptor signaling pathway via JAK-STAT	0.020435338939664285	0.020435338939664285	+1	VHL,PPP2R1A
GO:2000678	negative regulation of transcription regulatory region DNA binding	0.020435338939664285	0.020435338939664285	+1	TAF1,SIN3A
GO:0071425	hematopoietic stem cell proliferation	0.020435338939664285	0.020435338939664285	+1	RUNX1,MECOM
GO:0032869	cellular response to insulin stimulus	0.02073436502572411	0.02073436502572411	+1	PIK3CA,APC,PIK3R1,AKT1,PTPN11
GO:0007091	metaphase/anaphase transition of mitotic cell cycle	0.02091043138938887	0.02091043138938887	+1	APC,RB1,ATM
GO:0046328	regulation of JNK cascade	0.021268580949671545	0.021268580949671545	+1	EGFR,MAP2K4,MAPK8IP1,MECOM,NCOR1
GO:1902178	fibroblast growth factor receptor apoptotic signaling pathway	0.02166367041836995	0.02166367041836995	+1	FGFR3
GO:0002649	regulation of tolerance induction to self antigen	0.02166367041836995	0.02166367041836995	+1	TGFBR2
GO:0002651	positive regulation of tolerance induction to self antigen	0.02166367041836995	0.02166367041836995	+1	TGFBR2
GO:1990426	mitotic recombination-dependent replication fork processing	0.02166367041836995	0.02166367041836995	+1	BRCA2
GO:1905929	positive regulation of invadopodium disassembly	0.02166367041836995	0.02166367041836995	+1	NAV3
GO:1990505	mitotic DNA replication maintenance of fidelity	0.02166367041836995	0.02166367041836995	+1	BRCA2
GO:0003142	cardiogenic plate morphogenesis	0.02166367041836995	0.02166367041836995	+1	SOX17
GO:0043969	histone H2B acetylation	0.02166367041836995	0.02166367041836995	+1	EP300
GO:0003181	atrioventricular valve morphogenesis	0.02166367041836995	0.02166367041836995	+1	NOTCH1,TGFBR2
GO:1902298	cell cycle DNA replication maintenance of fidelity	0.02166367041836995	0.02166367041836995	+1	BRCA2
GO:0002253	activation of immune response	0.02166367041836995	0.02166367041836995	+1	PIK3CA,KRAS,PIK3R1,GATA3,MAP3K1,RUNX1,NRAS,TLR4,EP300,CBFB,SIN3A
GO:1903124	negative regulation of thioredoxin peroxidase activity	0.02166367041836995	0.02166367041836995	+1	LRRK2
GO:1905927	regulation of invadopodium disassembly	0.02166367041836995	0.02166367041836995	+1	NAV3
GO:0007221	positive regulation of transcription of Notch receptor target	0.02166367041836995	0.02166367041836995	+1	NOTCH1,EP300
GO:0001659	temperature homeostasis	0.02166367041836995	0.02166367041836995	+1	APC,RB1,NOTCH1,STK11,TLR4
GO:1905878	invadopodium disassembly	0.02166367041836995	0.02166367041836995	+1	NAV3
GO:0043161	proteasome-mediated ubiquitin-dependent protein catabolic process	0.02166367041836995	0.02166367041836995	+1	FBXW7,KEAP1,NFE2L2,CEBPA,LRRK2,TAF1,TBL1XR1,SPOP
GO:0001101	response to acid chemical	0.02166367041836995	0.02166367041836995	+1	EPHA3,SOX9,ATM,MTOR,ASXL1
GO:1904262	negative regulation of TORC1 signaling	0.02166367041836995	0.02166367041836995	+1	STK11,ATM
GO:0045951	positive regulation of mitotic recombination	0.02166367041836995	0.02166367041836995	+1	ERCC2
GO:1905317	inferior endocardial cushion morphogenesis	0.02166367041836995	0.02166367041836995	+1	TGFBR2
GO:1905305	negative regulation of cardiac myofibril assembly	0.02166367041836995	0.02166367041836995	+1	SMAD4
GO:1905304	regulation of cardiac myofibril assembly	0.02166367041836995	0.02166367041836995	+1	SMAD4
GO:1905277	negative regulation of epithelial tube formation	0.02166367041836995	0.02166367041836995	+1	GATA3
GO:1905208	negative regulation of cardiocyte differentiation	0.02166367041836995	0.02166367041836995	+1	EGFR,SMAD4
GO:0040030	regulation of molecular function, epigenetic	0.02166367041836995	0.02166367041836995	+1	CTCF
GO:0001836	release of cytochrome c from mitochondria	0.02166367041836995	0.02166367041836995	+1	TP53,AKT1,HGF
GO:1902629	regulation of mRNA stability involved in cellular response to UV	0.02166367041836995	0.02166367041836995	+1	NPM1
GO:2000733	regulation of glial cell-derived neurotrophic factor receptor signaling pathway involved in ureteric bud formation	0.02166367041836995	0.02166367041836995	+1	GATA3
GO:2000734	negative regulation of glial cell-derived neurotrophic factor receptor signaling pathway involved in ureteric bud formation	0.02166367041836995	0.02166367041836995	+1	GATA3
GO:2000808	negative regulation of synaptic vesicle clustering	0.02166367041836995	0.02166367041836995	+1	PTEN
GO:2000703	negative regulation of fibroblast growth factor receptor signaling pathway involved in ureteric bud formation	0.02166367041836995	0.02166367041836995	+1	GATA3
GO:1903123	regulation of thioredoxin peroxidase activity	0.02166367041836995	0.02166367041836995	+1	LRRK2
GO:2000970	regulation of detection of glucose	0.02166367041836995	0.02166367041836995	+1	FOXA2
GO:2000971	negative regulation of detection of glucose	0.02166367041836995	0.02166367041836995	+1	FOXA2
GO:2000702	regulation of fibroblast growth factor receptor signaling pathway involved in ureteric bud formation	0.02166367041836995	0.02166367041836995	+1	GATA3
GO:2000701	glial cell-derived neurotrophic factor receptor signaling pathway involved in ureteric bud formation	0.02166367041836995	0.02166367041836995	+1	GATA3
GO:2000699	fibroblast growth factor receptor signaling pathway involved in ureteric bud formation	0.02166367041836995	0.02166367041836995	+1	GATA3
GO:1904887	Wnt signalosome assembly	0.02166367041836995	0.02166367041836995	+1	LRRK2
GO:1903216	regulation of protein processing involved in protein targeting to mitochondrion	0.02166367041836995	0.02166367041836995	+1	LRRK2
GO:1903217	negative regulation of protein processing involved in protein targeting to mitochondrion	0.02166367041836995	0.02166367041836995	+1	LRRK2
GO:2000607	negative regulation of cell proliferation involved in mesonephros development	0.02166367041836995	0.02166367041836995	+1	GATA3
GO:2000606	regulation of cell proliferation involved in mesonephros development	0.02166367041836995	0.02166367041836995	+1	GATA3
GO:0006306	DNA methylation	0.02166367041836995	0.02166367041836995	+1	DNMT3A,WT1,ATRX
GO:0006305	DNA alkylation	0.02166367041836995	0.02166367041836995	+1	DNMT3A,WT1,ATRX
GO:0035602	fibroblast growth factor receptor signaling pathway involved in negative regulation of apoptotic process in bone marrow cell	0.02166367041836995	0.02166367041836995	+1	FGFR2
GO:0035603	fibroblast growth factor receptor signaling pathway involved in hemopoiesis	0.02166367041836995	0.02166367041836995	+1	FGFR2
GO:0003415	chondrocyte hypertrophy	0.02166367041836995	0.02166367041836995	+1	SOX9
GO:0007542	primary sex determination, germ-line	0.02166367041836995	0.02166367041836995	+1	SOX9
GO:0044784	metaphase/anaphase transition of cell cycle	0.02166367041836995	0.02166367041836995	+1	APC,RB1,ATM
GO:2000469	negative regulation of peroxidase activity	0.02166367041836995	0.02166367041836995	+1	LRRK2
GO:0007517	muscle organ development	0.02166367041836995	0.02166367041836995	+1	NOTCH1,WT1,ERBB4,FGFR2,SMAD4,EGR3
GO:0035604	fibroblast growth factor receptor signaling pathway involved in positive regulation of cell proliferation in bone marrow	0.02166367041836995	0.02166367041836995	+1	FGFR2
GO:0035607	fibroblast growth factor receptor signaling pathway involved in orbitofrontal cortex development	0.02166367041836995	0.02166367041836995	+1	FGFR2
GO:0045861	negative regulation of proteolysis	0.02166367041836995	0.02166367041836995	+1	CDKN2A,AKT1,HGF,LRRK2,TAF1,RPL5
GO:0044336	canonical Wnt signaling pathway involved in negative regulation of apoptotic process	0.02166367041836995	0.02166367041836995	+1	CTNNB1
GO:0003213	cardiac right atrium morphogenesis	0.02166367041836995	0.02166367041836995	+1	NOTCH1
GO:1904893	negative regulation of receptor signaling pathway via STAT	0.02166367041836995	0.02166367041836995	+1	VHL,PPP2R1A
GO:1903125	negative regulation of thioredoxin peroxidase activity by peptidyl-threonine phosphorylation	0.02166367041836995	0.02166367041836995	+1	LRRK2
GO:1901984	negative regulation of protein acetylation	0.02166367041836995	0.02166367041836995	+1	BRCA1,SIN3A
GO:0070512	positive regulation of histone H4-K20 methylation	0.02166367041836995	0.02166367041836995	+1	BRCA1
GO:0070510	regulation of histone H4-K20 methylation	0.02166367041836995	0.02166367041836995	+1	BRCA1
GO:0070413	trehalose metabolism in response to stress	0.02166367041836995	0.02166367041836995	+1	BRAF
GO:0070373	negative regulation of ERK1 and ERK2 cascade	0.02166367041836995	0.02166367041836995	+1	PTEN,TLR4,SMAD4
GO:0061987	negative regulation of transcription from RNA polymerase II promoter by glucose	0.02166367041836995	0.02166367041836995	+1	FOXA2
GO:0061986	negative regulation of transcription by glucose	0.02166367041836995	0.02166367041836995	+1	FOXA2
GO:0100002	negative regulation of protein kinase activity by protein phosphorylation	0.02166367041836995	0.02166367041836995	+1	AKT1
GO:0061921	peptidyl-lysine propionylation	0.02166367041836995	0.02166367041836995	+1	EP300
GO:0140067	peptidyl-lysine butyrylation	0.02166367041836995	0.02166367041836995	+1	EP300
GO:0061437	renal system vasculature development	0.02166367041836995	0.02166367041836995	+1	WT1,PDGFRA
GO:0061324	canonical Wnt signaling pathway involved in positive regulation of cardiac outflow tract cell proliferation	0.02166367041836995	0.02166367041836995	+1	CTNNB1
GO:0061290	canonical Wnt signaling pathway involved in metanephric kidney development	0.02166367041836995	0.02166367041836995	+1	GATA3
GO:0061289	Wnt signaling pathway involved in kidney development	0.02166367041836995	0.02166367041836995	+1	GATA3
GO:0097393	telomeric repeat-containing RNA transcription	0.02166367041836995	0.02166367041836995	+1	ATRX
GO:0061440	kidney vasculature development	0.02166367041836995	0.02166367041836995	+1	WT1,PDGFRA
GO:0021897	forebrain astrocyte development	0.02166367041836995	0.02166367041836995	+1	NF1
GO:0021896	forebrain astrocyte differentiation	0.02166367041836995	0.02166367041836995	+1	NF1
GO:0021769	orbitofrontal cortex development	0.02166367041836995	0.02166367041836995	+1	FGFR2
GO:0097326	melanocyte adhesion	0.02166367041836995	0.02166367041836995	+1	KIT
GO:0097306	cellular response to alcohol	0.02166367041836995	0.02166367041836995	+1	CTNNB1,CDH1,BRCA1
GO:0010810	regulation of cell-substrate adhesion	0.02166367041836995	0.02166367041836995	+1	PTEN,NF1,CDKN2A,NOTCH1,EPHA3
GO:0072659	protein localization to plasma membrane	0.02166367041836995	0.02166367041836995	+1	EGFR,PIK3R1,CDH1,EPHA3,AKT1,AR
GO:0072428	signal transduction involved in intra-S DNA damage checkpoint	0.02166367041836995	0.02166367041836995	+1	CHEK2
GO:0072362	regulation of glycolytic process by negative regulation of transcription from RNA polymerase II promoter	0.02166367041836995	0.02166367041836995	+1	NCOR1
GO:0010965	regulation of mitotic sister chromatid separation	0.02166367041836995	0.02166367041836995	+1	APC,RB1,ATM
GO:0072302	negative regulation of metanephric glomerular mesangial cell proliferation	0.02166367041836995	0.02166367041836995	+1	WT1
GO:0072299	negative regulation of metanephric glomerulus development	0.02166367041836995	0.02166367041836995	+1	WT1
GO:0072204	cell-cell signaling involved in metanephros development	0.02166367041836995	0.02166367041836995	+1	GATA3
GO:0072175	epithelial tube formation	0.02166367041836995	0.02166367041836995	+1	GATA3,SOX9,FGFR2
GO:0016046	detection of fungus	0.02166367041836995	0.02166367041836995	+1	TLR4
GO:0016071	mRNA metabolic process	0.02166367041836995	0.02166367041836995	+1	TP53,NPM1,AKT1,ATM,U2AF1,SOX17,SF3B1,PPP2R1A,RPL5,AXIN2,ERCC2,PCBP1
GO:0018992	germ-line sex determination	0.02166367041836995	0.02166367041836995	+1	SOX9
GO:0019100	male germ-line sex determination	0.02166367041836995	0.02166367041836995	+1	SOX9
GO:0060995	cell-cell signaling involved in kidney development	0.02166367041836995	0.02166367041836995	+1	GATA3
GO:1900259	regulation of RNA-directed 5'-3' RNA polymerase activity	0.02166367041836995	0.02166367041836995	+1	EIF4A2
GO:0061032	visceral serous pericardium development	0.02166367041836995	0.02166367041836995	+1	WT1
GO:0060843	venous endothelial cell differentiation	0.02166367041836995	0.02166367041836995	+1	NOTCH1
GO:1901581	negative regulation of telomeric RNA transcription from RNA pol II promoter	0.02166367041836995	0.02166367041836995	+1	ATRX
GO:0060915	mesenchymal cell differentiation involved in lung development	0.02166367041836995	0.02166367041836995	+1	FGFR2
GO:0060523	prostate epithelial cord elongation	0.02166367041836995	0.02166367041836995	+1	FGFR2
GO:1901582	positive regulation of telomeric RNA transcription from RNA pol II promoter	0.02166367041836995	0.02166367041836995	+1	ATRX
GO:0060517	epithelial cell proliferation involved in prostatic bud elongation	0.02166367041836995	0.02166367041836995	+1	SOX9
GO:0060516	primary prostatic bud elongation	0.02166367041836995	0.02166367041836995	+1	SOX9
GO:0060525	prostate glandular acinus development	0.02166367041836995	0.02166367041836995	+1	FGFR2
GO:0060463	lung lobe morphogenesis	0.02166367041836995	0.02166367041836995	+1	FGFR2
GO:0060449	bud elongation involved in lung branching	0.02166367041836995	0.02166367041836995	+1	FGFR2
GO:1901675	negative regulation of histone H3-K27 acetylation	0.02166367041836995	0.02166367041836995	+1	SIN3A
GO:0032275	luteinizing hormone secretion	0.02166367041836995	0.02166367041836995	+1	TBX3
GO:0060261	positive regulation of transcription initiation from RNA polymerase II promoter	0.02166367041836995	0.02166367041836995	+1	TP53,TAF1
GO:0055008	cardiac muscle tissue morphogenesis	0.02166367041836995	0.02166367041836995	+1	NOTCH1,FGFR2,SMAD4
GO:0051138	positive regulation of NK T cell differentiation	0.02166367041836995	0.02166367041836995	+1	TGFBR2
GO:0060462	lung lobe development	0.02166367041836995	0.02166367041836995	+1	FGFR2
GO:0060526	prostate glandular acinus morphogenesis	0.02166367041836995	0.02166367041836995	+1	FGFR2
GO:0097394	telomeric repeat-containing RNA transcription by RNA polymerase II	0.02166367041836995	0.02166367041836995	+1	ATRX
GO:0060527	prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis	0.02166367041836995	0.02166367041836995	+1	FGFR2
GO:0060784	regulation of cell proliferation involved in tissue homeostasis	0.02166367041836995	0.02166367041836995	+1	SOX9
GO:0060735	regulation of eIF2 alpha phosphorylation by dsRNA	0.02166367041836995	0.02166367041836995	+1	NPM1
GO:0060687	regulation of branching involved in prostate gland morphogenesis	0.02166367041836995	0.02166367041836995	+1	FGFR2
GO:1901580	regulation of telomeric RNA transcription from RNA pol II promoter	0.02166367041836995	0.02166367041836995	+1	ATRX
GO:0060670	branching involved in labyrinthine layer morphogenesis	0.02166367041836995	0.02166367041836995	+1	FGFR2
GO:0060667	branch elongation involved in salivary gland morphogenesis	0.02166367041836995	0.02166367041836995	+1	FGFR2
GO:0060796	regulation of transcription involved in primary germ layer cell fate commitment	0.02166367041836995	0.02166367041836995	+1	SOX17
GO:0060665	regulation of branching involved in salivary gland morphogenesis by mesenchymal-epithelial signaling	0.02166367041836995	0.02166367041836995	+1	HGF
GO:0060638	mesenchymal-epithelial cell signaling	0.02166367041836995	0.02166367041836995	+1	HGF
GO:0060807	regulation of transcription from RNA polymerase II promoter involved in definitive endodermal cell fate specification	0.02166367041836995	0.02166367041836995	+1	SOX17
GO:1900260	negative regulation of RNA-directed 5'-3' RNA polymerase activity	0.02166367041836995	0.02166367041836995	+1	EIF4A2
GO:0060615	mammary gland bud formation	0.02166367041836995	0.02166367041836995	+1	FGFR2
GO:0060529	squamous basal epithelial stem cell differentiation involved in prostate gland acinus development	0.02166367041836995	0.02166367041836995	+1	FGFR2
GO:0060648	mammary gland bud morphogenesis	0.02166367041836995	0.02166367041836995	+1	FGFR2
GO:0090087	regulation of peptide transport	0.022135152249590263	0.022135152249590263	+1	TP53,PIK3R1,GATA3,FBXW7,CDH1,BAP1,TLR4,LRRK2,SETD2,FOXA2
GO:0055017	cardiac muscle tissue growth	0.0223410397303331	0.0223410397303331	+1	NOTCH1,ERBB4,FGFR2
GO:0051784	negative regulation of nuclear division	0.0223410397303331	0.0223410397303331	+1	APC,ATM,ATRX
GO:1900182	positive regulation of protein localization to nucleus	0.0223410397303331	0.0223410397303331	+1	PIK3R1,CDH1,AKT1
GO:0042177	negative regulation of protein catabolic process	0.022633975967336854	0.022633975967336854	+1	EGFR,CDKN2A,TAF1,RPL5
GO:0002757	immune response-activating signal transduction	0.02291131043237325	0.02291131043237325	+1	PIK3CA,KRAS,PIK3R1,GATA3,MAP3K1,RUNX1,NRAS,TLR4,EP300,CBFB
GO:0007610	behavior	0.023100151105349902	0.023100151105349902	+1	TP53,PTEN,EGFR,NF1,LRRK2,FOXA2
GO:0046605	regulation of centrosome cycle	0.023130933344687212	0.023130933344687212	+1	CTNNB1,NPM1,BRCA1
GO:0007622	rhythmic behavior	0.023130933344687212	0.023130933344687212	+1	TP53,PTEN
GO:0016331	morphogenesis of embryonic epithelium	0.023130933344687212	0.023130933344687212	+1	GATA3,SOX9,FGFR2
GO:0048662	negative regulation of smooth muscle cell proliferation	0.023130933344687212	0.023130933344687212	+1	PTEN,CDKN1B,CDKN1A
GO:0051306	mitotic sister chromatid separation	0.023130933344687212	0.023130933344687212	+1	APC,RB1,ATM
GO:0043967	histone H4 acetylation	0.023130933344687212	0.023130933344687212	+1	BRCA1,EP300,BRCA2
GO:0051145	smooth muscle cell differentiation	0.023130933344687212	0.023130933344687212	+1	NOTCH1,KIT,FGFR2
GO:1902176	negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway	0.023130933344687212	0.023130933344687212	+1	NFE2L2,AKT1
GO:0014013	regulation of gliogenesis	0.023130933344687212	0.023130933344687212	+1	NF1,NOTCH1,MIR142
GO:0030851	granulocyte differentiation	0.023130933344687212	0.023130933344687212	+1	RUNX1,CEBPA
GO:0033233	regulation of protein sumoylation	0.023130933344687212	0.023130933344687212	+1	CDKN2A,CTNNB1
GO:0043297	apical junction assembly	0.023130933344687212	0.023130933344687212	+1	APC,RUNX1,CBFB
GO:0048839	inner ear development	0.023130933344687212	0.023130933344687212	+1	SOX9,FGFR2,PTPN11
GO:0030277	maintenance of gastrointestinal epithelium	0.023130933344687212	0.023130933344687212	+1	SOX9,TLR4
GO:0003158	endothelium development	0.023130933344687212	0.023130933344687212	+1	NOTCH1,CTNNB1,SOX17,VEZF1
GO:0008543	fibroblast growth factor receptor signaling pathway	0.023130933344687212	0.023130933344687212	+1	GATA3,FGFR2,FGFR3,PTPN11
GO:0021879	forebrain neuron differentiation	0.023130933344687212	0.023130933344687212	+1	ERBB4,FGFR2
GO:0007052	mitotic spindle organization	0.023130933344687212	0.023130933344687212	+1	STAG2,CHEK2,SMC1A,SMC3
GO:0045671	negative regulation of osteoclast differentiation	0.023130933344687212	0.023130933344687212	+1	FBXW7,TLR4
GO:0035315	hair cell differentiation	0.023130933344687212	0.023130933344687212	+1	CTNNB1,ERCC2
GO:0048512	circadian behavior	0.023130933344687212	0.023130933344687212	+1	TP53,PTEN
GO:0021955	central nervous system neuron axonogenesis	0.023130933344687212	0.023130933344687212	+1	PTEN,ARHGAP35
GO:0031667	response to nutrient levels	0.02321904623393265	0.02321904623393265	+1	TP53,MTOR,LRRK2,FOXA2,CDKN1A,TAF1
GO:0031349	positive regulation of defense response	0.023277003296227516	0.023277003296227516	+1	KRAS,MAP3K1,NRAS,CEBPA,TLR4,EP300,SIN3A,MIR142
GO:0001817	regulation of cytokine production	0.023668273937220388	0.023668273937220388	+1	NAV3,GATA3,CTNNB1,RUNX1,TLR4,BRCA1,SETD2,EP300,SMAD4,PTPN11
GO:0051053	negative regulation of DNA metabolic process	0.02375288093494434	0.02375288093494434	+1	TP53,ATM,POLQ,HIST1H1C
GO:0044255	cellular lipid metabolic process	0.023884873239086373	0.023884873239086373	+1	PIK3CA,PTEN,PIK3R1,FBXW7,FLT3,IDH1,AKT1,PIK3CG,BRCA1,KIT,PDGFRA,FGFR3,B4GALT3,PPP2R1A
GO:0032388	positive regulation of intracellular transport	0.023905995106718498	0.023905995106718498	+1	TP53,PIK3R1,FBXW7,CDH1,BAP1
GO:0032868	response to insulin	0.023905995106718498	0.023905995106718498	+1	PIK3CA,APC,PIK3R1,AKT1,PTPN11
GO:1901652	response to peptide	0.024033210167993608	0.024033210167993608	+1	TP53,PIK3CA,APC,PIK3R1,AKT1,TLR4,PTPN11
GO:0051222	positive regulation of protein transport	0.024033210167993608	0.024033210167993608	+1	TP53,PIK3R1,GATA3,FBXW7,CDH1,BAP1,TLR4
GO:0045844	positive regulation of striated muscle tissue development	0.02410397496989371	0.02410397496989371	+1	NOTCH1,ERBB4,FGFR2
GO:1901983	regulation of protein acetylation	0.02410397496989371	0.02410397496989371	+1	BRCA1,SMAD4,SIN3A
GO:0072332	intrinsic apoptotic signaling pathway by p53 class mediator	0.02410397496989371	0.02410397496989371	+1	TP53,STK11,EP300
GO:1903749	positive regulation of establishment of protein localization to mitochondrion	0.02410397496989371	0.02410397496989371	+1	TP53,FBXW7,BAP1
GO:0048636	positive regulation of muscle organ development	0.02410397496989371	0.02410397496989371	+1	NOTCH1,ERBB4,FGFR2
GO:0048710	regulation of astrocyte differentiation	0.025163425664331683	0.025163425664331683	+1	NOTCH1,MIR142
GO:0046639	negative regulation of alpha-beta T cell differentiation	0.025163425664331683	0.025163425664331683	+1	RUNX1,CBFB
GO:0001709	cell fate determination	0.025163425664331683	0.025163425664331683	+1	GATA3,SOX17
GO:0014014	negative regulation of gliogenesis	0.025163425664331683	0.025163425664331683	+1	NF1,NOTCH1
GO:0003171	atrioventricular valve development	0.025163425664331683	0.025163425664331683	+1	NOTCH1,TGFBR2
GO:0007043	cell-cell junction assembly	0.025163425664331683	0.025163425664331683	+1	APC,CDH1,RUNX1,CBFB
GO:0048384	retinoic acid receptor signaling pathway	0.025163425664331683	0.025163425664331683	+1	ASXL1,EZH2
GO:1905818	regulation of chromosome separation	0.025163425664331683	0.025163425664331683	+1	APC,RB1,ATM
GO:0006337	nucleosome disassembly	0.025163425664331683	0.025163425664331683	+1	ARID1A,PBRM1
GO:2000810	regulation of bicellular tight junction assembly	0.025163425664331683	0.025163425664331683	+1	RUNX1,CBFB
GO:1901863	positive regulation of muscle tissue development	0.025163425664331683	0.025163425664331683	+1	NOTCH1,ERBB4,FGFR2
GO:0003272	endocardial cushion formation	0.025163425664331683	0.025163425664331683	+1	NOTCH1,TGFBR2
GO:0045184	establishment of protein localization	0.025223738861514737	0.025223738861514737	+1	TP53,EGFR,PIK3R1,GATA3,FBXW7,CDH1,BAP1,NPM1,IDH1,AKT1,BRAF,ATM,TLR4,U2AF1,LRRK2,SETD2,FOXA2,USP9X,BRCA2,ATR,RPL5
GO:0008380	RNA splicing	0.025432655442957617	0.025432655442957617	+1	PIK3R1,WT1,PRX,U2AF1,SF3B1,PPP2R1A,CDK12,PCBP1
GO:1903051	negative regulation of proteolysis involved in cellular protein catabolic process	0.026237949268040624	0.026237949268040624	+1	CDKN2A,TAF1,RPL5
GO:0048644	muscle organ morphogenesis	0.026237949268040624	0.026237949268040624	+1	NOTCH1,FGFR2,SMAD4
GO:0010812	negative regulation of cell-substrate adhesion	0.026237949268040624	0.026237949268040624	+1	PTEN,CDKN2A,NOTCH1
GO:0060415	muscle tissue morphogenesis	0.026237949268040624	0.026237949268040624	+1	NOTCH1,FGFR2,SMAD4
GO:0002218	activation of innate immune response	0.026237949268040624	0.026237949268040624	+1	KRAS,MAP3K1,NRAS,TLR4,EP300,SIN3A
GO:0070988	demethylation	0.026237949268040624	0.026237949268040624	+1	KDM5C,TET2,USP9X
GO:0070201	regulation of establishment of protein localization	0.026832764352484578	0.026832764352484578	+1	TP53,PIK3R1,GATA3,FBXW7,CDH1,BAP1,TLR4,LRRK2,SETD2,FOXA2
GO:0042116	macrophage activation	0.027425773906944065	0.027425773906944065	+1	CEBPA,TLR4,MIR142
GO:0055006	cardiac cell development	0.027425773906944065	0.027425773906944065	+1	NOTCH1,PDGFRA,SMAD4
GO:0070301	cellular response to hydrogen peroxide	0.027425773906944065	0.027425773906944065	+1	NFE2L2,HGF,LRRK2
GO:0006360	transcription by RNA polymerase I	0.027425773906944065	0.027425773906944065	+1	MTOR,TAF1,ERCC2
GO:0050869	negative regulation of B cell activation	0.0274407057375729	0.0274407057375729	+1	CDKN2A,ATM
GO:0071459	protein localization to chromosome, centromeric region	0.0274407057375729	0.0274407057375729	+1	RB1,CTCF
GO:0051567	histone H3-K9 methylation	0.0274407057375729	0.0274407057375729	+1	ATRX,BRCA1
GO:0070723	response to cholesterol	0.0274407057375729	0.0274407057375729	+1	TGFBR2,SMAD2
GO:0048566	embryonic digestive tract development	0.0274407057375729	0.0274407057375729	+1	PDGFRA,FGFR2
GO:0007026	negative regulation of microtubule depolymerization	0.0274407057375729	0.0274407057375729	+1	APC,NAV3
GO:0014002	astrocyte development	0.0274407057375729	0.0274407057375729	+1	NF1,MIR142
GO:1901798	positive regulation of signal transduction by p53 class mediator	0.0274407057375729	0.0274407057375729	+1	ATM,ATR
GO:0010608	posttranscriptional regulation of gene expression	0.028206864946173617	0.028206864946173617	+1	TP53,EGFR,NPM1,AKT1,AJUBA,MTOR,EIF4A2,NCOR1,RPL5,SMAD2,AXIN2
GO:0060078	regulation of postsynaptic membrane potential	0.028548685786870233	0.028548685786870233	+1	PTEN,AKT1,LRRK2
GO:0007369	gastrulation	0.028790691318701902	0.028790691318701902	+1	SETD2,FOXA2,SOX17,SMAD2
GO:0006109	regulation of carbohydrate metabolic process	0.028790691318701902	0.028790691318701902	+1	AKT1,EP300,FOXA2,NCOR1
GO:0002429	immune response-activating cell surface receptor signaling pathway	0.029403355456347494	0.029403355456347494	+1	PIK3CA,KRAS,PIK3R1,GATA3,RUNX1,NRAS,EP300,CBFB
GO:2001236	regulation of extrinsic apoptotic signaling pathway	0.02960587502697482	0.02960587502697482	+1	PTEN,AKT1,AR,BRCA1
GO:0033135	regulation of peptidyl-serine phosphorylation	0.02960587502697482	0.02960587502697482	+1	EGFR,AKT1,BRAF,NSD1
GO:0009267	cellular response to starvation	0.02960587502697482	0.02960587502697482	+1	TP53,MTOR,LRRK2,CDKN1A
GO:0051298	centrosome duplication	0.029692365508049344	0.029692365508049344	+1	NPM1,BRCA1,BRCA2
GO:0030316	osteoclast differentiation	0.029692365508049344	0.029692365508049344	+1	FBXW7,MTOR,TLR4
GO:2000573	positive regulation of DNA biosynthetic process	0.029692365508049344	0.029692365508049344	+1	ATM,HGF,ATR
GO:0030510	regulation of BMP signaling pathway	0.029692365508049344	0.029692365508049344	+1	NOTCH1,SMAD4,SMAD2
GO:0035066	positive regulation of histone acetylation	0.02969632290375187	0.02969632290375187	+1	BRCA1,SMAD4
GO:0032727	positive regulation of interferon-alpha production	0.02969632290375187	0.02969632290375187	+1	TLR4,SETD2
GO:0070168	negative regulation of biomineral tissue development	0.02969632290375187	0.02969632290375187	+1	NOTCH1,SOX9
GO:0045922	negative regulation of fatty acid metabolic process	0.02969632290375187	0.02969632290375187	+1	AKT1,BRCA1
GO:0032986	protein-DNA complex disassembly	0.02969632290375187	0.02969632290375187	+1	ARID1A,PBRM1
GO:0046640	regulation of alpha-beta T cell proliferation	0.02969632290375187	0.02969632290375187	+1	TGFBR2,MAPK8IP1
GO:0009299	mRNA transcription	0.02969632290375187	0.02969632290375187	+1	TP53,SOX17
GO:2000515	negative regulation of CD4-positive, alpha-beta T cell activation	0.02969632290375187	0.02969632290375187	+1	RUNX1,CBFB
GO:0010669	epithelial structure maintenance	0.02969632290375187	0.02969632290375187	+1	SOX9,TLR4
GO:0032069	regulation of nuclease activity	0.02969632290375187	0.02969632290375187	+1	NPM1,AKT1
GO:2000209	regulation of anoikis	0.02969632290375187	0.02969632290375187	+1	PIK3CA,NOTCH1
GO:1904886	beta-catenin destruction complex disassembly	0.02969632290375187	0.02969632290375187	+1	APC,CTNNB1
GO:0031498	chromatin disassembly	0.02969632290375187	0.02969632290375187	+1	ARID1A,PBRM1
GO:0007098	centrosome cycle	0.03016319403947953	0.03016319403947953	+1	CTNNB1,NPM1,BRCA1,BRCA2
GO:0060349	bone morphogenesis	0.030719348267069832	0.030719348267069832	+1	SOX9,FGFR2,FGFR3
GO:0035924	cellular response to vascular endothelial growth factor stimulus	0.030719348267069832	0.030719348267069832	+1	NOTCH1,PDGFRA,EGR3
GO:0002223	stimulatory C-type lectin receptor signaling pathway	0.030719348267069832	0.030719348267069832	+1	KRAS,NRAS,EP300
GO:0002695	negative regulation of leukocyte activation	0.03099830615782096	0.03099830615782096	+1	CDKN2A,RUNX1,ATM,CBFB
GO:0043542	endothelial cell migration	0.0313859053858295	0.0313859053858295	+1	PIK3CA,NF1,GATA3,NOTCH1,AKT1,EGR3
GO:0000724	double-strand break repair via homologous recombination	0.0318871103877335	0.0318871103877335	+1	BRCA1,POLQ,SETD2,BRCA2
GO:0060541	respiratory system development	0.03202077004395974	0.03202077004395974	+1	CEBPA,WT1,FGFR2
GO:0055003	cardiac myofibril assembly	0.03215379962075987	0.03215379962075987	+1	PDGFRA,SMAD4
GO:0061515	myeloid cell development	0.03215379962075987	0.03215379962075987	+1	FBXW7,KIT
GO:0046633	alpha-beta T cell proliferation	0.03215379962075987	0.03215379962075987	+1	TGFBR2,MAPK8IP1
GO:0046599	regulation of centriole replication	0.03215379962075987	0.03215379962075987	+1	NPM1,BRCA1
GO:0045943	positive regulation of transcription by RNA polymerase I	0.03215379962075987	0.03215379962075987	+1	MTOR,TAF1
GO:0010614	negative regulation of cardiac muscle hypertrophy	0.03215379962075987	0.03215379962075987	+1	NOTCH1,SMAD4
GO:2000108	positive regulation of leukocyte apoptotic process	0.03215379962075987	0.03215379962075987	+1	TP53,CDKN2A
GO:0014741	negative regulation of muscle hypertrophy	0.03215379962075987	0.03215379962075987	+1	NOTCH1,SMAD4
GO:0048147	negative regulation of fibroblast proliferation	0.03215379962075987	0.03215379962075987	+1	TP53,NF1
GO:0000725	recombinational repair	0.03260546790800726	0.03260546790800726	+1	BRCA1,POLQ,SETD2,BRCA2
GO:0008366	axon ensheathment	0.033162033384123935	0.033162033384123935	+1	PTEN,NF1,PRX
GO:0007272	ensheathment of neurons	0.033162033384123935	0.033162033384123935	+1	PTEN,NF1,PRX
GO:0031058	positive regulation of histone modification	0.033162033384123935	0.033162033384123935	+1	CTNNB1,BRCA1,SMAD4
GO:0045814	negative regulation of gene expression, epigenetic	0.03347804088347947	0.03347804088347947	+1	DNMT3A,HIST1H1C,SIN3A,EZH2
GO:0007254	JNK cascade	0.03365946948530965	0.03365946948530965	+1	EGFR,MAP2K4,MAPK8IP1,MECOM,NCOR1
GO:0043902	positive regulation of multi-organism process	0.03382252866227804	0.03382252866227804	+1	KRAS,MAP3K1,NRAS,TLR4,EP300,SIN3A,ACVR1B,SMC3
GO:0071229	cellular response to acid chemical	0.03438546877818879	0.03438546877818879	+1	EPHA3,SOX9,ATM,MTOR
GO:0060389	pathway-restricted SMAD protein phosphorylation	0.034448384058763576	0.034448384058763576	+1	SMAD4,TGFBR2,ACVR2A
GO:0002220	innate immune response activating cell surface receptor signaling pathway	0.034448384058763576	0.034448384058763576	+1	KRAS,NRAS,EP300
GO:0051865	protein autoubiquitination	0.034448384058763576	0.034448384058763576	+1	BRCA1,LRRK2,TAF1
GO:0042307	positive regulation of protein import into nucleus	0.03464641358492468	0.03464641358492468	+1	PIK3R1,CDH1
GO:0051123	RNA polymerase II preinitiation complex assembly	0.03464641358492468	0.03464641358492468	+1	TP53,TAF1
GO:2000273	positive regulation of signaling receptor activity	0.03464641358492468	0.03464641358492468	+1	FBXW7,TAF1
GO:1902895	positive regulation of pri-miRNA transcription by RNA polymerase II	0.03464641358492468	0.03464641358492468	+1	TP53,WT1
GO:0034405	response to fluid shear stress	0.03464641358492468	0.03464641358492468	+1	NFE2L2,AKT1
GO:0061311	cell surface receptor signaling pathway involved in heart development	0.03464641358492468	0.03464641358492468	+1	NOTCH1,CTNNB1
GO:0060317	cardiac epithelial to mesenchymal transition	0.03464641358492468	0.03464641358492468	+1	NOTCH1,TGFBR2
GO:0034332	adherens junction organization	0.03508768644448008	0.03508768644448008	+1	PTEN,CTNNB1,CDH1,EPHA3
GO:0043010	camera-type eye development	0.03508768644448008	0.03508768644448008	+1	NF1,SOX9,WT1,PDGFRA
GO:0000187	activation of MAPK activity	0.03508768644448008	0.03508768644448008	+1	MAP2K4,TLR4,LRRK2,KIT
GO:0030218	erythrocyte differentiation	0.03558098654995466	0.03558098654995466	+1	KIT,ACVR1B,ACVR2A
GO:0030193	regulation of blood coagulation	0.03558098654995466	0.03558098654995466	+1	TLR4,PDGFRA,FOXA2
GO:1900046	regulation of hemostasis	0.03558098654995466	0.03558098654995466	+1	TLR4,PDGFRA,FOXA2
GO:0071887	leukocyte apoptotic process	0.03558098654995466	0.03558098654995466	+1	TP53,CDKN2A,AKT1
GO:0007584	response to nutrient	0.03558098654995466	0.03558098654995466	+1	MTOR,FOXA2,TAF1
GO:0035710	CD4-positive, alpha-beta T cell activation	0.036776930178885565	0.036776930178885565	+1	RUNX1,TGFBR2,CBFB
GO:0031114	regulation of microtubule depolymerization	0.036776930178885565	0.036776930178885565	+1	APC,NAV3
GO:0036314	response to sterol	0.036776930178885565	0.036776930178885565	+1	TGFBR2,SMAD2
GO:0060484	lung-associated mesenchyme development	0.036776930178885565	0.036776930178885565	+1	FGFR2
GO:0050769	positive regulation of neurogenesis	0.036776930178885565	0.036776930178885565	+1	NOTCH1,CTNNB1,ARHGAP35,EPHA3,EP300,MIR142
GO:0036369	transcription factor catabolic process	0.036776930178885565	0.036776930178885565	+1	TAF1
GO:1901674	regulation of histone H3-K27 acetylation	0.036776930178885565	0.036776930178885565	+1	SIN3A
GO:0060442	branching involved in prostate gland morphogenesis	0.036776930178885565	0.036776930178885565	+1	FGFR2
GO:0051049	regulation of transport	0.036776930178885565	0.036776930178885565	+1	TP53,PTEN,PIK3R1,GATA3,NOTCH1,FBXW7,CTNNB1,CDH1,BAP1,EPHA3,AKT1,BRAF,TLR4,LRRK2,SETD2,FOXA2,PTPN11,NCOR1
GO:0002663	positive regulation of B cell tolerance induction	0.036776930178885565	0.036776930178885565	+1	TGFBR2
GO:0045084	positive regulation of interleukin-12 biosynthetic process	0.036776930178885565	0.036776930178885565	+1	TLR4
GO:0036216	cellular response to stem cell factor stimulus	0.036776930178885565	0.036776930178885565	+1	KIT
GO:0060326	cell chemotaxis	0.036776930178885565	0.036776930178885565	+1	NOTCH1,PIK3CG,HGF,KIT,PDGFRA,EGR3
GO:0038109	Kit signaling pathway	0.036776930178885565	0.036776930178885565	+1	KIT
GO:0060260	regulation of transcription initiation from RNA polymerase II promoter	0.036776930178885565	0.036776930178885565	+1	TP53,TAF1
GO:0060221	retinal rod cell differentiation	0.036776930178885565	0.036776930178885565	+1	SOX9
GO:0060056	mammary gland involution	0.036776930178885565	0.036776930178885565	+1	ELF3
GO:0060024	rhythmic synaptic transmission	0.036776930178885565	0.036776930178885565	+1	PTEN
GO:0051704	multi-organism process	0.036776930178885565	0.036776930178885565	+1	TP53,PTEN,KRAS,GATA3,CTNNB1,MAP3K1,CDH1,NRAS,PIK3CG,SOX9,WT1,TLR4,KIT,SETD2,EP300,USP9X,BRCA2,SIN3A,PTPN11,ACVR1B,SMC3,PCBP1
GO:1901963	regulation of cell proliferation involved in outflow tract morphogenesis	0.036776930178885565	0.036776930178885565	+1	CTNNB1
GO:0140066	peptidyl-lysine crotonylation	0.036776930178885565	0.036776930178885565	+1	EP300
GO:0042098	T cell proliferation	0.036776930178885565	0.036776930178885565	+1	CDKN2A,PIK3CG,TGFBR2,MAPK8IP1
GO:0002661	regulation of B cell tolerance induction	0.036776930178885565	0.036776930178885565	+1	TGFBR2
GO:1902499	positive regulation of protein autoubiquitination	0.036776930178885565	0.036776930178885565	+1	LRRK2
GO:0043974	histone H3-K27 acetylation	0.036776930178885565	0.036776930178885565	+1	SIN3A
GO:0036215	response to stem cell factor	0.036776930178885565	0.036776930178885565	+1	KIT
GO:0003250	regulation of cell proliferation involved in heart valve morphogenesis	0.036776930178885565	0.036776930178885565	+1	NOTCH1
GO:0000717	nucleotide-excision repair, DNA duplex unwinding	0.036776930178885565	0.036776930178885565	+1	ERCC2
GO:0003249	cell proliferation involved in heart valve morphogenesis	0.036776930178885565	0.036776930178885565	+1	NOTCH1
GO:0035801	adrenal cortex development	0.036776930178885565	0.036776930178885565	+1	WT1
GO:1902823	negative regulation of late endosome to lysosome transport	0.036776930178885565	0.036776930178885565	+1	LRRK2
GO:0003220	left ventricular cardiac muscle tissue morphogenesis	0.036776930178885565	0.036776930178885565	+1	SMAD4
GO:0060767	epithelial cell proliferation involved in prostate gland development	0.036776930178885565	0.036776930178885565	+1	SOX9
GO:0044334	canonical Wnt signaling pathway involved in positive regulation of epithelial to mesenchymal transition	0.036776930178885565	0.036776930178885565	+1	CTNNB1
GO:0060916	mesenchymal cell proliferation involved in lung development	0.036776930178885565	0.036776930178885565	+1	FGFR2
GO:0060948	cardiac vascular smooth muscle cell development	0.036776930178885565	0.036776930178885565	+1	NOTCH1
GO:0035802	adrenal cortex formation	0.036776930178885565	0.036776930178885565	+1	WT1
GO:0060693	regulation of branching involved in salivary gland morphogenesis	0.036776930178885565	0.036776930178885565	+1	HGF
GO:0044262	cellular carbohydrate metabolic process	0.036776930178885565	0.036776930178885565	+1	PTEN,AKT1,BRAF,EP300,FOXA2
GO:1900224	positive regulation of nodal signaling pathway involved in determination of lateral mesoderm left/right asymmetry	0.036776930178885565	0.036776930178885565	+1	SMAD2
GO:0061031	endodermal digestive tract morphogenesis	0.036776930178885565	0.036776930178885565	+1	SOX17
GO:1902751	positive regulation of cell cycle G2/M phase transition	0.036776930178885565	0.036776930178885565	+1	NPM1,CCND1
GO:0003169	coronary vein morphogenesis	0.036776930178885565	0.036776930178885565	+1	NOTCH1
GO:0060664	epithelial cell proliferation involved in salivary gland morphogenesis	0.036776930178885565	0.036776930178885565	+1	FGFR2
GO:0060601	lateral sprouting from an epithelium	0.036776930178885565	0.036776930178885565	+1	FGFR2
GO:0043006	activation of phospholipase A2 activity by calcium-mediated signaling	0.036776930178885565	0.036776930178885565	+1	EGFR
GO:0060594	mammary gland specification	0.036776930178885565	0.036776930178885565	+1	FGFR2
GO:0060592	mammary gland formation	0.036776930178885565	0.036776930178885565	+1	FGFR2
GO:0060572	morphogenesis of an epithelial bud	0.036776930178885565	0.036776930178885565	+1	FGFR2
GO:0003252	negative regulation of cell proliferation involved in heart valve morphogenesis	0.036776930178885565	0.036776930178885565	+1	NOTCH1
GO:0060595	fibroblast growth factor receptor signaling pathway involved in mammary gland specification	0.036776930178885565	0.036776930178885565	+1	FGFR2
GO:0032707	negative regulation of interleukin-23 production	0.036776930178885565	0.036776930178885565	+1	TLR4
GO:0072166	posterior mesonephric tubule development	0.036776930178885565	0.036776930178885565	+1	WT1
GO:0021869	forebrain ventricular zone progenitor cell division	0.036776930178885565	0.036776930178885565	+1	FGFR2
GO:0046632	alpha-beta T cell differentiation	0.036776930178885565	0.036776930178885565	+1	RUNX1,TGFBR2,CBFB
GO:0099403	maintenance of mitotic sister chromatid cohesion, telomeric	0.036776930178885565	0.036776930178885565	+1	ATRX
GO:0072301	regulation of metanephric glomerular mesangial cell proliferation	0.036776930178885565	0.036776930178885565	+1	WT1
GO:0021872	forebrain generation of neurons	0.036776930178885565	0.036776930178885565	+1	ERBB4,FGFR2
GO:0099404	mitotic sister chromatid cohesion, telomeric	0.036776930178885565	0.036776930178885565	+1	ATRX
GO:1990428	miRNA transport	0.036776930178885565	0.036776930178885565	+1	TGFBR2
GO:1990418	response to insulin-like growth factor stimulus	0.036776930178885565	0.036776930178885565	+1	AKT1
GO:1903336	negative regulation of vacuolar transport	0.036776930178885565	0.036776930178885565	+1	LRRK2
GO:0072361	regulation of glycolytic process by regulation of transcription from RNA polymerase II promoter	0.036776930178885565	0.036776930178885565	+1	NCOR1
GO:0021551	central nervous system morphogenesis	0.036776930178885565	0.036776930178885565	+1	ERBB4
GO:0072368	regulation of lipid transport by negative regulation of transcription from RNA polymerase II promoter	0.036776930178885565	0.036776930178885565	+1	NCOR1
GO:1905863	invadopodium organization	0.036776930178885565	0.036776930178885565	+1	NAV3
GO:0034770	histone H4-K20 methylation	0.036776930178885565	0.036776930178885565	+1	BRCA1
GO:1905524	negative regulation of protein autoubiquitination	0.036776930178885565	0.036776930178885565	+1	TAF1
GO:0021860	pyramidal neuron development	0.036776930178885565	0.036776930178885565	+1	FGFR2
GO:0010906	regulation of glucose metabolic process	0.036776930178885565	0.036776930178885565	+1	AKT1,EP300,FOXA2
GO:0098679	regulation of carbohydrate catabolic process by regulation of transcription from RNA polymerase II promoter	0.036776930178885565	0.036776930178885565	+1	NCOR1
GO:0072034	renal vesicle induction	0.036776930178885565	0.036776930178885565	+1	SOX9
GO:0071372	cellular response to follicle-stimulating hormone stimulus	0.036776930178885565	0.036776930178885565	+1	NOTCH1
GO:2000683	regulation of cellular response to X-ray	0.036776930178885565	0.036776930178885565	+1	GATA3
GO:0016578	histone deubiquitination	0.036776930178885565	0.036776930178885565	+1	BAP1,ASXL1
GO:2000639	negative regulation of SREBP signaling pathway	0.036776930178885565	0.036776930178885565	+1	FBXW7
GO:2000620	positive regulation of histone H4-K16 acetylation	0.036776930178885565	0.036776930178885565	+1	BRCA1
GO:2000468	regulation of peroxidase activity	0.036776930178885565	0.036776930178885565	+1	LRRK2
GO:0045740	positive regulation of DNA replication	0.036776930178885565	0.036776930178885565	+1	EGFR,ATRX
GO:0021847	ventricular zone neuroblast division	0.036776930178885565	0.036776930178885565	+1	FGFR2
GO:0071866	negative regulation of apoptotic process in bone marrow cell	0.036776930178885565	0.036776930178885565	+1	FGFR2
GO:2001074	regulation of metanephric ureteric bud development	0.036776930178885565	0.036776930178885565	+1	WT1
GO:2001076	positive regulation of metanephric ureteric bud development	0.036776930178885565	0.036776930178885565	+1	WT1
GO:2000346	negative regulation of hepatocyte proliferation	0.036776930178885565	0.036776930178885565	+1	FBXW7
GO:0045720	negative regulation of integrin biosynthetic process	0.036776930178885565	0.036776930178885565	+1	AR
GO:0014036	neural crest cell fate specification	0.036776930178885565	0.036776930178885565	+1	SOX9
GO:2000195	negative regulation of female gonad development	0.036776930178885565	0.036776930178885565	+1	WT1
GO:0021859	pyramidal neuron differentiation	0.036776930178885565	0.036776930178885565	+1	FGFR2
GO:0048617	embryonic foregut morphogenesis	0.036776930178885565	0.036776930178885565	+1	SOX17
GO:0045639	positive regulation of myeloid cell differentiation	0.036776930178885565	0.036776930178885565	+1	RUNX1,ACVR1B,ACVR2A
GO:2000758	positive regulation of peptidyl-lysine acetylation	0.036776930178885565	0.036776930178885565	+1	BRCA1,SMAD4
GO:0097324	melanocyte migration	0.036776930178885565	0.036776930178885565	+1	KIT
GO:1904907	regulation of maintenance of mitotic sister chromatid cohesion, telomeric	0.036776930178885565	0.036776930178885565	+1	ATRX
GO:1903464	negative regulation of mitotic cell cycle DNA replication	0.036776930178885565	0.036776930178885565	+1	CHEK2
GO:1904908	negative regulation of maintenance of mitotic sister chromatid cohesion, telomeric	0.036776930178885565	0.036776930178885565	+1	ATRX
GO:1904761	negative regulation of myofibroblast differentiation	0.036776930178885565	0.036776930178885565	+1	RB1
GO:0035359	negative regulation of peroxisome proliferator activated receptor signaling pathway	0.036776930178885565	0.036776930178885565	+1	ASXL1
GO:0010768	negative regulation of transcription from RNA polymerase II promoter in response to UV-induced DNA damage	0.036776930178885565	0.036776930178885565	+1	TAF1
GO:1904028	positive regulation of collagen fibril organization	0.036776930178885565	0.036776930178885565	+1	RB1
GO:1903378	positive regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway	0.036776930178885565	0.036776930178885565	+1	FBXW7
GO:0045976	negative regulation of mitotic cell cycle, embryonic	0.036776930178885565	0.036776930178885565	+1	CTNNB1
GO:0080111	DNA demethylation	0.036776930178885565	0.036776930178885565	+1	TET2,USP9X
GO:1905279	regulation of retrograde transport, endosome to Golgi	0.036776930178885565	0.036776930178885565	+1	LRRK2
GO:0007538	primary sex determination	0.036776930178885565	0.036776930178885565	+1	SOX9
GO:0007406	negative regulation of neuroblast proliferation	0.036776930178885565	0.036776930178885565	+1	NF1
GO:1905289	regulation of CAMKK-AMPK signaling cascade	0.036776930178885565	0.036776930178885565	+1	LRRK2
GO:0007440	foregut morphogenesis	0.036776930178885565	0.036776930178885565	+1	SOX17
GO:0097156	fasciculation of motor neuron axon	0.036776930178885565	0.036776930178885565	+1	EPHA3
GO:0048866	stem cell fate specification	0.036776930178885565	0.036776930178885565	+1	SOX9
GO:0007352	zygotic specification of dorsal/ventral axis	0.036776930178885565	0.036776930178885565	+1	SMAD2
GO:1903463	regulation of mitotic cell cycle DNA replication	0.036776930178885565	0.036776930178885565	+1	CHEK2
GO:1990778	protein localization to cell periphery	0.03683369505130472	0.03683369505130472	+1	EGFR,PIK3R1,CDH1,EPHA3,AKT1,AR
GO:1904951	positive regulation of establishment of protein localization	0.037302707506896966	0.037302707506896966	+1	TP53,PIK3R1,GATA3,FBXW7,CDH1,BAP1,TLR4
GO:0045833	negative regulation of lipid metabolic process	0.03734459552754208	0.03734459552754208	+1	FBXW7,AKT1,BRCA1
GO:0045742	positive regulation of epidermal growth factor receptor signaling pathway	0.03734459552754208	0.03734459552754208	+1	FBXW7,AKT1
GO:0051154	negative regulation of striated muscle cell differentiation	0.03734459552754208	0.03734459552754208	+1	NOTCH1,SMAD4
GO:0042594	response to starvation	0.03734459552754208	0.03734459552754208	+1	TP53,MTOR,LRRK2,CDKN1A
GO:0017145	stem cell division	0.03734459552754208	0.03734459552754208	+1	CDKN2A,FGFR2
GO:1904591	positive regulation of protein import	0.03734459552754208	0.03734459552754208	+1	PIK3R1,CDH1
GO:0051179	localization	0.03734459552754208	0.03734459552754208	+1	TP53,PIK3CA,PTEN,APC,NAV3,EGFR,NF1,PIK3R1,GATA3,RB1,NOTCH1,FBXW7,CTNNB1,KEAP1,CDH1,ARHGAP35,CTCF,BAP1,NPM1,NRAS,IDH1,TBX3,EPHA3,AKT1,BRAF,AR,EPPK1,PIK3CG,SOX9,ATM,HGF,ERBB4,MTOR,TLR4,U2AF1,ATRX,LRRK2,KIT,SETD2,PDGFRA,FOXA2,USP9X,BRCA2,TGFBR2,PPP2R1A,ATR,SIN3A,PTPN11,ACVR1B,MAPK8IP1,EGR3,NCOR1,RPL5,AXIN2,RAD21
GO:0062014	negative regulation of small molecule metabolic process	0.03734459552754208	0.03734459552754208	+1	AKT1,BRCA1,EP300
GO:1904705	regulation of vascular smooth muscle cell proliferation	0.03734459552754208	0.03734459552754208	+1	PTEN,CDKN1B,CDKN1A
GO:0001942	hair follicle development	0.03734459552754208	0.03734459552754208	+1	SOX9,FGFR2
GO:0098815	modulation of excitatory postsynaptic potential	0.03734459552754208	0.03734459552754208	+1	PTEN,LRRK2
GO:1903363	negative regulation of cellular protein catabolic process	0.03734459552754208	0.03734459552754208	+1	CDKN2A,TAF1,RPL5
GO:0000729	DNA double-strand break processing	0.03734459552754208	0.03734459552754208	+1	ATM,BRCA1
GO:0043407	negative regulation of MAP kinase activity	0.03734459552754208	0.03734459552754208	+1	NF1,PPP2R1A,MAPK8IP1
GO:0045589	regulation of regulatory T cell differentiation	0.03734459552754208	0.03734459552754208	+1	RUNX1,CBFB
GO:0010499	proteasomal ubiquitin-independent protein catabolic process	0.03734459552754208	0.03734459552754208	+1	KEAP1,NFE2L2
GO:1990874	vascular smooth muscle cell proliferation	0.03734459552754208	0.03734459552754208	+1	PTEN,CDKN1B,CDKN1A
GO:0043303	mast cell degranulation	0.03734459552754208	0.03734459552754208	+1	PIK3CG,KIT
GO:0050855	regulation of B cell receptor signaling pathway	0.03734459552754208	0.03734459552754208	+1	RUNX1,CBFB
GO:0061001	regulation of dendritic spine morphogenesis	0.03734459552754208	0.03734459552754208	+1	PTEN,LRRK2
GO:0030258	lipid modification	0.03734459552754208	0.03734459552754208	+1	PIK3CA,PTEN,PIK3R1,AKT1,PIK3CG
GO:0045648	positive regulation of erythrocyte differentiation	0.03734459552754208	0.03734459552754208	+1	ACVR1B,ACVR2A
GO:0010498	proteasomal protein catabolic process	0.03765011834344076	0.03765011834344076	+1	FBXW7,KEAP1,NFE2L2,CEBPA,LRRK2,TAF1,TBL1XR1,SPOP
GO:0045088	regulation of innate immune response	0.03788919510344028	0.03788919510344028	+1	KRAS,MAP3K1,NRAS,TLR4,EP300,SIN3A,PTPN11
GO:0034101	erythrocyte homeostasis	0.0383858289086148	0.0383858289086148	+1	KIT,ACVR1B,ACVR2A
GO:0030901	midbrain development	0.0383858289086148	0.0383858289086148	+1	CTNNB1,FGFR2,TAF1
GO:1903533	regulation of protein targeting	0.0383858289086148	0.0383858289086148	+1	FBXW7,BAP1,LRRK2
GO:0050818	regulation of coagulation	0.0383858289086148	0.0383858289086148	+1	TLR4,PDGFRA,FOXA2
GO:0097485	neuron projection guidance	0.03935495203021143	0.03935495203021143	+1	PIK3CA,PIK3R1,ARHGAP35,EPHA3,PTPN11
GO:0007411	axon guidance	0.03935495203021143	0.03935495203021143	+1	PIK3CA,PIK3R1,ARHGAP35,EPHA3,PTPN11
GO:0022405	hair cycle process	0.03973125800966196	0.03973125800966196	+1	SOX9,FGFR2
GO:0002279	mast cell activation involved in immune response	0.03973125800966196	0.03973125800966196	+1	PIK3CG,KIT
GO:0055094	response to lipoprotein particle	0.03973125800966196	0.03973125800966196	+1	AKT1,TLR4
GO:0051984	positive regulation of chromosome segregation	0.03973125800966196	0.03973125800966196	+1	RB1,RAD21
GO:0022404	molting cycle process	0.03973125800966196	0.03973125800966196	+1	SOX9,FGFR2
GO:0031023	microtubule organizing center organization	0.03973125800966196	0.03973125800966196	+1	CTNNB1,NPM1,BRCA1,BRCA2
GO:0060416	response to growth hormone	0.03973125800966196	0.03973125800966196	+1	PIK3R1,AKT1
GO:0006739	NADP metabolic process	0.03973125800966196	0.03973125800966196	+1	IDH1,IDH2
GO:0060765	regulation of androgen receptor signaling pathway	0.03973125800966196	0.03973125800966196	+1	EP300,NCOR1
GO:0032607	interferon-alpha production	0.03973125800966196	0.03973125800966196	+1	TLR4,SETD2
GO:0045216	cell-cell junction organization	0.03973125800966196	0.03973125800966196	+1	APC,CDH1,RUNX1,CBFB
GO:0032890	regulation of organic acid transport	0.03973125800966196	0.03973125800966196	+1	AKT1,NCOR1
GO:0032647	regulation of interferon-alpha production	0.03973125800966196	0.03973125800966196	+1	TLR4,SETD2
GO:0006476	protein deacetylation	0.03973125800966196	0.03973125800966196	+1	EP300,SIN3A,TBL1XR1
GO:0002448	mast cell mediated immunity	0.03973125800966196	0.03973125800966196	+1	PIK3CG,KIT
GO:0043543	protein acylation	0.04060320853458528	0.04060320853458528	+1	BRCA1,EP300,SMAD4,BRCA2,SIN3A
GO:0006446	regulation of translational initiation	0.040967974390490665	0.040967974390490665	+1	NPM1,MTOR,EIF4A2
GO:0061448	connective tissue development	0.04158951076739875	0.04158951076739875	+1	SOX9,WT1,ARID5B,FGFR3
GO:0031098	stress-activated protein kinase signaling cascade	0.04165070394248241	0.04165070394248241	+1	EGFR,MAP3K1,MAP2K4,MAPK8IP1,MECOM,NCOR1
GO:0006470	protein dephosphorylation	0.04215484980832453	0.04215484980832453	+1	PTEN,STK11,MTOR,PPP2R1A,PTPN11
GO:0070231	T cell apoptotic process	0.042241811243738416	0.042241811243738416	+1	TP53,AKT1
GO:0045066	regulatory T cell differentiation	0.042241811243738416	0.042241811243738416	+1	RUNX1,CBFB
GO:0070167	regulation of biomineral tissue development	0.042241811243738416	0.042241811243738416	+1	NOTCH1,SOX9,ACVR2A
GO:1904407	positive regulation of nitric oxide metabolic process	0.042241811243738416	0.042241811243738416	+1	AKT1,TLR4
GO:0010543	regulation of platelet activation	0.042241811243738416	0.042241811243738416	+1	TLR4,PDGFRA
GO:0045429	positive regulation of nitric oxide biosynthetic process	0.042241811243738416	0.042241811243738416	+1	AKT1,TLR4
GO:0060173	limb development	0.042241811243738416	0.042241811243738416	+1	CTNNB1,TBX3,FGFR2
GO:0008544	epidermis development	0.042241811243738416	0.042241811243738416	+1	CTNNB1,RUNX1,SOX9,ELF3,FGFR2,CBFB,ERCC2
GO:0071276	cellular response to cadmium ion	0.042241811243738416	0.042241811243738416	+1	EGFR,AKT1
GO:0048736	appendage development	0.042241811243738416	0.042241811243738416	+1	CTNNB1,TBX3,FGFR2
GO:0071402	cellular response to lipoprotein particle stimulus	0.042241811243738416	0.042241811243738416	+1	AKT1,TLR4
GO:0098773	skin epidermis development	0.042241811243738416	0.042241811243738416	+1	SOX9,FGFR2
GO:0034333	adherens junction assembly	0.042241811243738416	0.042241811243738416	+1	PTEN,CTNNB1,EPHA3
GO:1901186	positive regulation of ERBB signaling pathway	0.042241811243738416	0.042241811243738416	+1	FBXW7,AKT1
GO:0051100	negative regulation of binding	0.04225496614060962	0.04225496614060962	+1	AKT1,LRRK2,TAF1,SIN3A
GO:0046677	response to antibiotic	0.04330785500903077	0.04330785500903077	+1	TP53,NFE2L2,HGF,LRRK2
GO:0032872	regulation of stress-activated MAPK cascade	0.0434257933617154	0.0434257933617154	+1	EGFR,MAP2K4,MAPK8IP1,MECOM,NCOR1
GO:1905897	regulation of response to endoplasmic reticulum stress	0.04350078045753478	0.04350078045753478	+1	PIK3R1,NFE2L2,LRRK2
GO:0030282	bone mineralization	0.04350078045753478	0.04350078045753478	+1	FGFR2,FGFR3,ACVR2A
GO:0042542	response to hydrogen peroxide	0.04350078045753478	0.04350078045753478	+1	NFE2L2,HGF,LRRK2
GO:0006283	transcription-coupled nucleotide-excision repair	0.04350078045753478	0.04350078045753478	+1	CRIPAK,EP300,ERCC2
GO:0070302	regulation of stress-activated protein kinase signaling cascade	0.044154276516982505	0.044154276516982505	+1	EGFR,MAP2K4,MAPK8IP1,MECOM,NCOR1
GO:0090288	negative regulation of cellular response to growth factor stimulus	0.04420389607655858	0.04420389607655858	+1	GATA3,NOTCH1,TGFBR2,SMAD2
GO:0042593	glucose homeostasis	0.04420389607655858	0.04420389607655858	+1	PIK3R1,STK11,CEBPA,FOXA2
GO:0031018	endocrine pancreas development	0.0448130081571546	0.0448130081571546	+1	AKT1,FOXA2
GO:0042472	inner ear morphogenesis	0.0448130081571546	0.0448130081571546	+1	SOX9,FGFR2
GO:0010677	negative regulation of cellular carbohydrate metabolic process	0.0448130081571546	0.0448130081571546	+1	EP300,FOXA2
GO:0071354	cellular response to interleukin-6	0.0448130081571546	0.0448130081571546	+1	SMAD4,PTPN11
GO:0046636	negative regulation of alpha-beta T cell activation	0.0448130081571546	0.0448130081571546	+1	RUNX1,CBFB
GO:2000352	negative regulation of endothelial cell apoptotic process	0.0448130081571546	0.0448130081571546	+1	GATA3,NFE2L2
GO:0032728	positive regulation of interferon-beta production	0.0448130081571546	0.0448130081571546	+1	TLR4,PTPN11
GO:0045616	regulation of keratinocyte differentiation	0.0448130081571546	0.0448130081571546	+1	RUNX1,CBFB
GO:0033500	carbohydrate homeostasis	0.04508390074591893	0.04508390074591893	+1	PIK3R1,STK11,CEBPA,FOXA2
GO:0035601	protein deacylation	0.04632083579948899	0.04632083579948899	+1	EP300,SIN3A,TBL1XR1
GO:0042058	regulation of epidermal growth factor receptor signaling pathway	0.04632083579948899	0.04632083579948899	+1	EGFR,FBXW7,AKT1
GO:0098732	macromolecule deacylation	0.04632083579948899	0.04632083579948899	+1	EP300,SIN3A,TBL1XR1
GO:0048871	multicellular organismal homeostasis	0.04650685321413531	0.04650685321413531	+1	APC,NF1,RB1,NOTCH1,STK11,SOX9,TLR4
GO:0001959	regulation of cytokine-mediated signaling pathway	0.047203998404339045	0.047203998404339045	+1	RUNX1,CBFB,PTPN11,LIFR
GO:0097028	dendritic cell differentiation	0.047549991073792486	0.047549991073792486	+1	FLT3,TGFBR2
GO:0046825	regulation of protein export from nucleus	0.047549991073792486	0.047549991073792486	+1	TP53,SETD2
GO:0001658	branching involved in ureteric bud morphogenesis	0.047549991073792486	0.047549991073792486	+1	SOX9,WT1
GO:0031057	negative regulation of histone modification	0.047549991073792486	0.047549991073792486	+1	BRCA1,SIN3A
GO:0031572	G2 DNA damage checkpoint	0.047549991073792486	0.047549991073792486	+1	ATM,BRCA1
GO:0021761	limbic system development	0.047549991073792486	0.047549991073792486	+1	PTEN,FGFR2
GO:0070897	transcription preinitiation complex assembly	0.047549991073792486	0.047549991073792486	+1	TP53,TAF1
GO:0032204	regulation of telomere maintenance	0.04769490280143451	0.04769490280143451	+1	ATM,ATRX,ATR
GO:0120035	regulation of plasma membrane bounded cell projection organization	0.04869829266037729	0.04869829266037729	+1	PTEN,APC,NAV3,ARHGAP35,EPHA3,AKT1,LRRK2,EP300
GO:0048386	positive regulation of retinoic acid receptor signaling pathway	0.04875982973775921	0.04875982973775921	+1	ASXL1
GO:0036022	limb joint morphogenesis	0.04875982973775921	0.04875982973775921	+1	CTNNB1
GO:0072717	cellular response to actinomycin D	0.04875982973775921	0.04875982973775921	+1	TP53
GO:0030997	regulation of centriole-centriole cohesion	0.04875982973775921	0.04875982973775921	+1	CTNNB1
GO:0045075	regulation of interleukin-12 biosynthetic process	0.04875982973775921	0.04875982973775921	+1	TLR4
GO:0010767	regulation of transcription from RNA polymerase II promoter in response to UV-induced DNA damage	0.04875982973775921	0.04875982973775921	+1	TAF1
GO:0045089	positive regulation of innate immune response	0.04875982973775921	0.04875982973775921	+1	KRAS,MAP3K1,NRAS,TLR4,EP300,SIN3A
GO:0042306	regulation of protein import into nucleus	0.04875982973775921	0.04875982973775921	+1	PIK3R1,CDH1
GO:0090194	negative regulation of glomerulus development	0.04875982973775921	0.04875982973775921	+1	WT1
GO:0042090	interleukin-12 biosynthetic process	0.04875982973775921	0.04875982973775921	+1	TLR4
GO:0050868	negative regulation of T cell activation	0.04875982973775921	0.04875982973775921	+1	CDKN2A,RUNX1,CBFB
GO:0035510	DNA dealkylation	0.04875982973775921	0.04875982973775921	+1	TET2,USP9X
GO:0010750	positive regulation of nitric oxide mediated signal transduction	0.04875982973775921	0.04875982973775921	+1	EGFR
GO:0061325	cell proliferation involved in outflow tract morphogenesis	0.04875982973775921	0.04875982973775921	+1	CTNNB1
GO:0071839	apoptotic process in bone marrow cell	0.04875982973775921	0.04875982973775921	+1	FGFR2
GO:0051136	regulation of NK T cell differentiation	0.04875982973775921	0.04875982973775921	+1	TGFBR2
GO:1903691	positive regulation of wound healing, spreading of epidermal cells	0.04875982973775921	0.04875982973775921	+1	MTOR
GO:2000807	regulation of synaptic vesicle clustering	0.04875982973775921	0.04875982973775921	+1	PTEN
GO:0046533	negative regulation of photoreceptor cell differentiation	0.04875982973775921	0.04875982973775921	+1	SOX9
GO:0046532	regulation of photoreceptor cell differentiation	0.04875982973775921	0.04875982973775921	+1	SOX9
GO:2000793	cell proliferation involved in heart valve development	0.04875982973775921	0.04875982973775921	+1	NOTCH1
GO:0097681	double-strand break repair via alternative nonhomologous end joining	0.04875982973775921	0.04875982973775921	+1	POLQ
GO:0006407	rRNA export from nucleus	0.04875982973775921	0.04875982973775921	+1	NPM1
GO:1902730	positive regulation of proteoglycan biosynthetic process	0.04875982973775921	0.04875982973775921	+1	CTNNB1
GO:0000430	regulation of transcription from RNA polymerase II promoter by glucose	0.04875982973775921	0.04875982973775921	+1	FOXA2
GO:0000432	positive regulation of transcription from RNA polymerase II promoter by glucose	0.04875982973775921	0.04875982973775921	+1	FOXA2
GO:0042766	nucleosome mobilization	0.04875982973775921	0.04875982973775921	+1	ARID1A
GO:0003192	mitral valve formation	0.04875982973775921	0.04875982973775921	+1	NOTCH1
GO:2000825	positive regulation of androgen receptor activity	0.04875982973775921	0.04875982973775921	+1	TAF1
GO:0048873	homeostasis of number of cells within a tissue	0.04875982973775921	0.04875982973775921	+1	SOX9
GO:0019857	5-methylcytosine metabolic process	0.04875982973775921	0.04875982973775921	+1	TET2
GO:0035986	senescence-associated heterochromatin focus assembly	0.04875982973775921	0.04875982973775921	+1	CDKN2A
GO:1903971	positive regulation of response to macrophage colony-stimulating factor	0.04875982973775921	0.04875982973775921	+1	TLR4
GO:1903974	positive regulation of cellular response to macrophage colony-stimulating factor stimulus	0.04875982973775921	0.04875982973775921	+1	TLR4
GO:1903984	positive regulation of TRAIL-activated apoptotic signaling pathway	0.04875982973775921	0.04875982973775921	+1	PTEN
GO:0006356	regulation of transcription by RNA polymerase I	0.04875982973775921	0.04875982973775921	+1	MTOR,TAF1
GO:0097252	oligodendrocyte apoptotic process	0.04875982973775921	0.04875982973775921	+1	TP53
GO:0007182	common-partner SMAD protein phosphorylation	0.04875982973775921	0.04875982973775921	+1	SMAD2
GO:0048340	paraxial mesoderm morphogenesis	0.04875982973775921	0.04875982973775921	+1	SMAD2
GO:0046016	positive regulation of transcription by glucose	0.04875982973775921	0.04875982973775921	+1	FOXA2
GO:0048339	paraxial mesoderm development	0.04875982973775921	0.04875982973775921	+1	SMAD2
GO:0097155	fasciculation of sensory neuron axon	0.04875982973775921	0.04875982973775921	+1	EPHA3
GO:1904760	regulation of myofibroblast differentiation	0.04875982973775921	0.04875982973775921	+1	RB1
GO:0031134	sister chromatid biorientation	0.04875982973775921	0.04875982973775921	+1	RB1
GO:0051443	positive regulation of ubiquitin-protein transferase activity	0.04875982973775921	0.04875982973775921	+1	PTEN,FBXW7
GO:0006913	nucleocytoplasmic transport	0.04875982973775921	0.04875982973775921	+1	TP53,PIK3R1,CDH1,NPM1,U2AF1,SETD2
GO:0009794	regulation of mitotic cell cycle, embryonic	0.04875982973775921	0.04875982973775921	+1	CTNNB1
GO:0045448	mitotic cell cycle, embryonic	0.04875982973775921	0.04875982973775921	+1	CTNNB1
GO:0032497	detection of lipopolysaccharide	0.04875982973775921	0.04875982973775921	+1	TLR4
GO:0097676	histone H3-K36 dimethylation	0.04875982973775921	0.04875982973775921	+1	SETD2
GO:0034183	negative regulation of maintenance of mitotic sister chromatid cohesion	0.04875982973775921	0.04875982973775921	+1	ATRX
GO:0002666	positive regulation of T cell tolerance induction	0.04875982973775921	0.04875982973775921	+1	TGFBR2
GO:2000111	positive regulation of macrophage apoptotic process	0.04875982973775921	0.04875982973775921	+1	CDKN2A
GO:0072262	metanephric glomerular mesangial cell proliferation involved in metanephros development	0.04875982973775921	0.04875982973775921	+1	WT1
GO:0072275	metanephric glomerulus morphogenesis	0.04875982973775921	0.04875982973775921	+1	PDGFRA
GO:0072276	metanephric glomerulus vasculature morphogenesis	0.04875982973775921	0.04875982973775921	+1	PDGFRA
GO:0072179	nephric duct formation	0.04875982973775921	0.04875982973775921	+1	GATA3
GO:0060374	mast cell differentiation	0.04875982973775921	0.04875982973775921	+1	KIT
GO:0060913	cardiac cell fate determination	0.04875982973775921	0.04875982973775921	+1	SOX17
GO:0070662	mast cell proliferation	0.04875982973775921	0.04875982973775921	+1	KIT
GO:1903335	regulation of vacuolar transport	0.04875982973775921	0.04875982973775921	+1	LRRK2
GO:0032808	lacrimal gland development	0.04875982973775921	0.04875982973775921	+1	FGFR2
GO:0002514	B cell tolerance induction	0.04875982973775921	0.04875982973775921	+1	TGFBR2
GO:2000609	regulation of thyroid hormone generation	0.04875982973775921	0.04875982973775921	+1	GATA3
GO:0072277	metanephric glomerular capillary formation	0.04875982973775921	0.04875982973775921	+1	PDGFRA
GO:0031935	regulation of chromatin silencing	0.04875982973775921	0.04875982973775921	+1	HIST1H1C,SIN3A
GO:0038091	positive regulation of cell proliferation by VEGF-activated platelet derived growth factor receptor signaling pathway	0.04875982973775921	0.04875982973775921	+1	PDGFRA
GO:0038086	VEGF-activated platelet-derived growth factor receptor signaling pathway	0.04875982973775921	0.04875982973775921	+1	PDGFRA
GO:0071865	regulation of apoptotic process in bone marrow cell	0.04875982973775921	0.04875982973775921	+1	FGFR2
GO:2001023	regulation of response to drug	0.04875982973775921	0.04875982973775921	+1	NFE2L2,HGF,LRRK2
GO:1902339	positive regulation of apoptotic process involved in morphogenesis	0.04875982973775921	0.04875982973775921	+1	NOTCH1
GO:0060501	positive regulation of epithelial cell proliferation involved in lung morphogenesis	0.04875982973775921	0.04875982973775921	+1	FGFR2
GO:0045726	positive regulation of integrin biosynthetic process	0.04875982973775921	0.04875982973775921	+1	AR
GO:0002762	negative regulation of myeloid leukocyte differentiation	0.04875982973775921	0.04875982973775921	+1	FBXW7,TLR4
GO:0046686	response to cadmium ion	0.04875982973775921	0.04875982973775921	+1	EGFR,AKT1
GO:0014041	regulation of neuron maturation	0.04875982973775921	0.04875982973775921	+1	LRRK2
GO:1902822	regulation of late endosome to lysosome transport	0.04875982973775921	0.04875982973775921	+1	LRRK2
GO:2001205	negative regulation of osteoclast development	0.04875982973775921	0.04875982973775921	+1	FBXW7
GO:2000172	regulation of branching morphogenesis of a nerve	0.04875982973775921	0.04875982973775921	+1	LRRK2
GO:0014034	neural crest cell fate commitment	0.04875982973775921	0.04875982973775921	+1	SOX9
GO:0072125	negative regulation of glomerular mesangial cell proliferation	0.04875982973775921	0.04875982973775921	+1	WT1
GO:0098693	regulation of synaptic vesicle cycle	0.04875982973775921	0.04875982973775921	+1	PTEN,LRRK2
GO:0071930	negative regulation of transcription involved in G1/S transition of mitotic cell cycle	0.04875982973775921	0.04875982973775921	+1	RB1
GO:0010389	regulation of G2/M transition of mitotic cell cycle	0.04875982973775921	0.04875982973775921	+1	CDKN2A,ATM,CCND1,PPP2R1A
GO:0003273	cell migration involved in endocardial cushion formation	0.04875982973775921	0.04875982973775921	+1	NOTCH1
GO:0043516	regulation of DNA damage response, signal transduction by p53 class mediator	0.04875982973775921	0.04875982973775921	+1	ATM,ATR
GO:1905457	negative regulation of lymphoid progenitor cell differentiation	0.04875982973775921	0.04875982973775921	+1	NOTCH1
GO:0048861	leukemia inhibitory factor signaling pathway	0.04875982973775921	0.04875982973775921	+1	LIFR
GO:0006990	positive regulation of transcription from RNA polymerase II promoter involved in unfolded protein response	0.04875982973775921	0.04875982973775921	+1	EP300
GO:0072434	signal transduction involved in mitotic G2 DNA damage checkpoint	0.04875982973775921	0.04875982973775921	+1	ATM
GO:0006211	5-methylcytosine catabolic process	0.04875982973775921	0.04875982973775921	+1	TET2
GO:0040036	regulation of fibroblast growth factor receptor signaling pathway	0.04875982973775921	0.04875982973775921	+1	GATA3,FGFR2
GO:0034092	negative regulation of maintenance of sister chromatid cohesion	0.04875982973775921	0.04875982973775921	+1	ATRX
GO:0045967	negative regulation of growth rate	0.04875982973775921	0.04875982973775921	+1	NOTCH1
GO:0072657	protein localization to membrane	0.04875982973775921	0.04875982973775921	+1	TP53,EGFR,PIK3R1,CDH1,EPHA3,AKT1,BRAF,AR,RPL5
GO:0032286	central nervous system myelin maintenance	0.04875982973775921	0.04875982973775921	+1	PTEN
GO:0001776	leukocyte homeostasis	0.04875982973775921	0.04875982973775921	+1	FLT3,AKT1
GO:0036023	embryonic skeletal limb joint morphogenesis	0.04875982973775921	0.04875982973775921	+1	CTNNB1
GO:0061218	negative regulation of mesonephros development	0.04875982973775921	0.04875982973775921	+1	GATA3
GO:0001704	formation of primary germ layer	0.04875982973775921	0.04875982973775921	+1	SETD2,SOX17,SMAD2
GO:0035564	regulation of kidney size	0.04875982973775921	0.04875982973775921	+1	LRRK2
GO:0061209	cell proliferation involved in mesonephros development	0.04875982973775921	0.04875982973775921	+1	GATA3
GO:0010908	regulation of heparan sulfate proteoglycan biosynthetic process	0.04875982973775921	0.04875982973775921	+1	CTNNB1
GO:0002262	myeloid cell homeostasis	0.04875982973775921	0.04875982973775921	+1	KIT,ACVR1B,ACVR2A
GO:2000611	positive regulation of thyroid hormone generation	0.04875982973775921	0.04875982973775921	+1	GATA3
GO:0002513	tolerance induction to self antigen	0.04875982973775921	0.04875982973775921	+1	TGFBR2
GO:1905940	negative regulation of gonad development	0.04875982973775921	0.04875982973775921	+1	WT1
GO:0005991	trehalose metabolic process	0.04875982973775921	0.04875982973775921	+1	BRAF
GO:0038162	erythropoietin-mediated signaling pathway	0.04875982973775921	0.04875982973775921	+1	KIT
GO:0060214	endocardium formation	0.04875982973775921	0.04875982973775921	+1	SOX17
GO:0022028	tangential migration from the subventricular zone to the olfactory bulb	0.04875982973775921	0.04875982973775921	+1	LRRK2
GO:2000974	negative regulation of pro-B cell differentiation	0.04875982973775921	0.04875982973775921	+1	NOTCH1
GO:0060742	epithelial cell differentiation involved in prostate gland development	0.04875982973775921	0.04875982973775921	+1	FGFR2
GO:0010909	positive regulation of heparan sulfate proteoglycan biosynthetic process	0.04875982973775921	0.04875982973775921	+1	CTNNB1
GO:2000638	regulation of SREBP signaling pathway	0.04875982973775921	0.04875982973775921	+1	FBXW7
GO:0040019	positive regulation of embryonic development	0.04875982973775921	0.04875982973775921	+1	GATA3,FOXA2
GO:0031999	negative regulation of fatty acid beta-oxidation	0.04875982973775921	0.04875982973775921	+1	AKT1
GO:0032354	response to follicle-stimulating hormone	0.04875982973775921	0.04875982973775921	+1	NOTCH1
GO:0002331	pre-B cell allelic exclusion	0.04875982973775921	0.04875982973775921	+1	ATM
GO:0002318	myeloid progenitor cell differentiation	0.04875982973775921	0.04875982973775921	+1	FLT3
GO:0031344	regulation of cell projection organization	0.0490216759885893	0.0490216759885893	+1	PTEN,APC,NAV3,ARHGAP35,EPHA3,AKT1,LRRK2,EP300
GO:2001237	negative regulation of extrinsic apoptotic signaling pathway	0.04937996912844556	0.04937996912844556	+1	AKT1,AR,BRCA1
GO:2001243	negative regulation of intrinsic apoptotic signaling pathway	0.04937996912844556	0.04937996912844556	+1	NFE2L2,AKT1,LRRK2
GO:0051304	chromosome separation	0.04937996912844556	0.04937996912844556	+1	APC,RB1,ATM
GO:0051169	nuclear transport	0.049608813921143274	0.049608813921143274	+1	TP53,PIK3R1,CDH1,NPM1,U2AF1,SETD2
REAC:R-HSA-5663202	Diseases of signal transduction	1.1689183291930617e-16	1.1689183291930617e-16	+1	PIK3CA,PTEN,APC,KRAS,EGFR,NF1,PIK3R1,NOTCH1,FBXW7,CTNNB1,NRAS,AKT1,BRAF,CDKN1B,HGF,ERBB4,MTOR,KIT,PDGFRA,EP300,FGFR2,SMAD4,FGFR3,TGFBR2,CDKN1A,PPP2R1A,PTPN11,TBL1XR1,NCOR1,SMAD2
REAC:R-HSA-212436	Generic Transcription Pathway	1.0465427293779605e-12	1.0465427293779605e-12	+1	TP53,PTEN,KRAS,ARID1A,PBRM1,EGFR,CDKN2A,GATA3,RB1,NOTCH1,FBXW7,CTNNB1,NPM1,RUNX1,STK11,AKT1,AR,SOX9,ATM,CDKN1B,MTOR,BRCA1,CHEK2,KIT,EP300,CCND1,SMAD4,USP9X,CDKN1A,TAF1,PPP2R1A,CBFB,ATR,SIN3A,HIST1H2BD,CDK12,PTPN11,TBL1XR1,LIFR,NCOR1,SMAD2,ERCC2,EZH2
REAC:R-HSA-74160	Gene expression (Transcription)	1.5657277157303706e-12	1.5657277157303706e-12	+1	TP53,PTEN,KRAS,ARID1A,PBRM1,EGFR,CDKN2A,GATA3,RB1,NOTCH1,FBXW7,CTNNB1,DNMT3A,NPM1,RUNX1,STK11,AKT1,AR,SOX9,ATM,CDKN1B,MTOR,U2AF1,TET2,BRCA1,CHEK2,KIT,EP300,CCND1,SMAD4,USP9X,CDKN1A,SF3B1,TAF1,PPP2R1A,CBFB,ATR,SIN3A,HIST1H2BD,CDK12,PTPN11,TBL1XR1,LIFR,NCOR1,SMAD2,ERCC2,EZH2
REAC:R-HSA-73857	RNA Polymerase II Transcription	4.042926327226386e-12	4.042926327226386e-12	+1	TP53,PTEN,KRAS,ARID1A,PBRM1,EGFR,CDKN2A,GATA3,RB1,NOTCH1,FBXW7,CTNNB1,NPM1,RUNX1,STK11,AKT1,AR,SOX9,ATM,CDKN1B,MTOR,U2AF1,BRCA1,CHEK2,KIT,EP300,CCND1,SMAD4,USP9X,CDKN1A,TAF1,PPP2R1A,CBFB,ATR,SIN3A,HIST1H2BD,CDK12,PTPN11,TBL1XR1,LIFR,NCOR1,SMAD2,ERCC2,EZH2
REAC:R-HSA-2219528	PI3K/AKT Signaling in Cancer	4.271610196946854e-12	4.271610196946854e-12	+1	PIK3CA,PTEN,EGFR,PIK3R1,AKT1,CDKN1B,HGF,ERBB4,MTOR,KIT,PDGFRA,FGFR2,FGFR3,CDKN1A,PTPN11
REAC:R-HSA-1643685	Disease	6.725252186401744e-12	6.725252186401744e-12	+1	PIK3CA,PTEN,APC,KRAS,EGFR,NF1,PIK3R1,NOTCH1,FBXW7,CTNNB1,CDH1,NPM1,NRAS,IDH1,MAP2K4,AKT1,BRAF,CDKN1B,HGF,ERBB4,MTOR,TLR4,KIT,PDGFRA,EP300,FGFR2,SMAD4,FGFR3,TGFBR2,CDKN1A,TAF1,PPP2R1A,SIN3A,PTPN11,TBL1XR1,NCOR1,RPL5,SMAD2,ERCC2
REAC:R-HSA-1257604	PIP3 activates AKT signaling	7.638912144824518e-10	7.638912144824518e-10	+1	TP53,PIK3CA,PTEN,EGFR,PIK3R1,AKT1,CDKN1B,HGF,ERBB4,MTOR,KIT,PDGFRA,FGFR2,FGFR3,CDKN1A,PPP2R1A,PTPN11,MECOM,EZH2
REAC:R-HSA-199418	Negative regulation of the PI3K/AKT network	2.8797049276677354e-9	2.8797049276677354e-9	+1	PIK3CA,PTEN,EGFR,PIK3R1,AKT1,HGF,ERBB4,KIT,PDGFRA,FGFR2,FGFR3,PPP2R1A,PTPN11
REAC:R-HSA-9006925	Intracellular signaling by second messengers	4.522855639486291e-9	4.522855639486291e-9	+1	TP53,PIK3CA,PTEN,EGFR,PIK3R1,AKT1,CDKN1B,HGF,ERBB4,MTOR,KIT,PDGFRA,FGFR2,FGFR3,CDKN1A,PPP2R1A,PTPN11,MECOM,EZH2
REAC:R-HSA-162582	Signal Transduction	5.292006680367378e-9	5.292006680367378e-9	+1	TP53,PIK3CA,PTEN,APC,KRAS,EGFR,NF1,PIK3R1,GATA3,NOTCH1,FBXW7,CTNNB1,FLT3,CDH1,ARHGAP35,RUNX1,NRAS,STK11,AKT1,STAG2,BRAF,AR,PIK3CG,SOX9,CDKN1B,HGF,ERBB4,MTOR,ELF3,LRRK2,FOXA1,KIT,PDGFRA,EP300,FGFR2,CCND1,SMAD4,USP9X,FGFR3,TGFBR2,SOX17,CDKN1A,PPP2R1A,CBFB,HIST1H2BD,SMC1A,PTPN11,ACVR1B,TBL1XR1,ACVR2A,MECOM,SMC3,NCOR1,SMAD2,SPOP,AXIN2,RAD21,EZH2
REAC:R-HSA-8951936	RUNX3 regulates p14-ARF	1.1739426779504918e-8	1.1739426779504918e-8	+1	KRAS,CDKN2A,RUNX1,EP300,CCND1,CBFB
REAC:R-HSA-6811558	PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling	1.335848039263031e-8	1.335848039263031e-8	+1	PIK3CA,EGFR,PIK3R1,AKT1,HGF,ERBB4,KIT,PDGFRA,FGFR2,FGFR3,PPP2R1A,PTPN11
REAC:R-HSA-2219530	Constitutive Signaling by Aberrant PI3K in Cancer	9.632497326587266e-8	9.632497326587266e-8	+1	PIK3CA,EGFR,PIK3R1,HGF,ERBB4,KIT,PDGFRA,FGFR2,FGFR3,PTPN11
REAC:R-HSA-8878159	Transcriptional regulation by RUNX3	1.1391609684839412e-7	1.1391609684839412e-7	+1	TP53,KRAS,CDKN2A,NOTCH1,CTNNB1,RUNX1,EP300,CCND1,SMAD4,CDKN1A,CBFB
REAC:R-HSA-8848021	Signaling by PTK6	1.1391609684839412e-7	1.1391609684839412e-7	+1	KRAS,EGFR,ARHGAP35,NRAS,AKT1,CDKN1B,ERBB4,LRRK2,CCND1
REAC:R-HSA-9006927	Signaling by Non-Receptor Tyrosine Kinases	1.1391609684839412e-7	1.1391609684839412e-7	+1	KRAS,EGFR,ARHGAP35,NRAS,AKT1,CDKN1B,ERBB4,LRRK2,CCND1
REAC:R-HSA-5654741	Signaling by FGFR3	1.8937343835913184e-7	1.8937343835913184e-7	+1	PIK3CA,KRAS,PIK3R1,NRAS,BRAF,FGFR3,PPP2R1A,PTPN11
REAC:R-HSA-3700989	Transcriptional Regulation by TP53	6.762869791288202e-7	6.762869791288202e-7	+1	TP53,PTEN,CDKN2A,NPM1,STK11,AKT1,ATM,CDKN1B,MTOR,BRCA1,CHEK2,EP300,CDKN1A,TAF1,PPP2R1A,ATR,CDK12,ERCC2
REAC:R-HSA-112399	IRS-mediated signalling	7.79081040161006e-7	7.79081040161006e-7	+1	PIK3CA,KRAS,PIK3R1,FLT3,NRAS,FGFR2,FGFR3,PTPN11
REAC:R-HSA-3108232	SUMO E3 ligases SUMOylate target proteins	8.12099997713226e-7	8.12099997713226e-7	+1	TP53,VHL,CDKN2A,DNMT3A,NPM1,STAG2,AR,BRCA1,EP300,SIN3A,SMC1A,SMC3,RAD21
REAC:R-HSA-8853334	Signaling by FGFR3 fusions in cancer	8.12099997713226e-7	8.12099997713226e-7	+1	PIK3CA,KRAS,PIK3R1,NRAS,FGFR3
REAC:R-HSA-9018519	Estrogen-dependent gene expression	8.97881688167611e-7	8.97881688167611e-7	+1	GATA3,RUNX1,STAG2,ERBB4,FOXA1,EP300,CCND1,CBFB,HIST1H2BD,SMC1A,SMC3,RAD21
REAC:R-HSA-2990846	SUMOylation	0.0000010857285087049892	0.0000010857285087049892	+1	TP53,VHL,CDKN2A,DNMT3A,NPM1,STAG2,AR,BRCA1,EP300,SIN3A,SMC1A,SMC3,RAD21
REAC:R-HSA-5688426	Deubiquitination	0.0000010857285087049892	0.0000010857285087049892	+1	TP53,PTEN,APC,GATA3,KEAP1,BAP1,AR,BRCA1,EP300,SMAD4,USP9X,ASXL1,TGFBR2,HIST1H2BD,SMAD2,AXIN2
REAC:R-HSA-2428928	IRS-related events triggered by IGF1R	0.0000011430692035662232	0.0000011430692035662232	+1	PIK3CA,KRAS,PIK3R1,FLT3,NRAS,FGFR2,FGFR3,PTPN11
REAC:R-HSA-8939211	ESR-mediated signaling	0.0000011792577958197043	0.0000011792577958197043	+1	GATA3,RUNX1,STAG2,ERBB4,FOXA1,EP300,CCND1,CBFB,HIST1H2BD,SMC1A,SMC3,RAD21
REAC:R-HSA-2428924	IGF1R signaling cascade	0.0000012364742810732473	0.0000012364742810732473	+1	PIK3CA,KRAS,PIK3R1,FLT3,NRAS,FGFR2,FGFR3,PTPN11
REAC:R-HSA-6804757	Regulation of TP53 Degradation	0.000001299037721275586	0.000001299037721275586	+1	TP53,CDKN2A,AKT1,ATM,MTOR,CHEK2,PPP2R1A
REAC:R-HSA-2404192	Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)	0.000001299037721275586	0.000001299037721275586	+1	PIK3CA,KRAS,PIK3R1,FLT3,NRAS,FGFR2,FGFR3,PTPN11
REAC:R-HSA-74751	Insulin receptor signalling cascade	0.000001299037721275586	0.000001299037721275586	+1	PIK3CA,KRAS,PIK3R1,FLT3,NRAS,FGFR2,FGFR3,PTPN11
REAC:R-HSA-5633007	Regulation of TP53 Activity	0.0000013117740320986147	0.0000013117740320986147	+1	TP53,CDKN2A,STK11,AKT1,ATM,MTOR,BRCA1,CHEK2,EP300,TAF1,PPP2R1A,ATR
REAC:R-HSA-6806003	Regulation of TP53 Expression and Degradation	0.0000014899368912791776	0.0000014899368912791776	+1	TP53,CDKN2A,AKT1,ATM,MTOR,CHEK2,PPP2R1A
REAC:R-HSA-3247509	Chromatin modifying enzymes	0.0000016728567297274875	0.0000016728567297274875	+1	ARID1A,PBRM1,DNMT3A,KDM6A,KDM5C,ARID5B,SETD2,EP300,CCND1,HIST1H2BD,NSD1,TBL1XR1,MECOM,NCOR1,EZH2
REAC:R-HSA-4839726	Chromatin organization	0.0000016728567297274875	0.0000016728567297274875	+1	ARID1A,PBRM1,DNMT3A,KDM6A,KDM5C,ARID5B,SETD2,EP300,CCND1,HIST1H2BD,NSD1,TBL1XR1,MECOM,NCOR1,EZH2
REAC:R-HSA-9006934	Signaling by Receptor Tyrosine Kinases	0.0000017013251684094328	0.0000017013251684094328	+1	PIK3CA,KRAS,EGFR,PIK3R1,CTNNB1,FLT3,NRAS,AKT1,BRAF,HGF,ERBB4,MTOR,KIT,PDGFRA,FGFR2,FGFR3,PPP2R1A,PTPN11,NCOR1
REAC:R-HSA-5654708	Downstream signaling of activated FGFR3	0.000002683383597460574	0.000002683383597460574	+1	PIK3CA,KRAS,PIK3R1,NRAS,FGFR3,PTPN11
REAC:R-HSA-5654743	Signaling by FGFR4	0.0000027244758204977804	0.0000027244758204977804	+1	PIK3CA,KRAS,PIK3R1,NRAS,BRAF,PPP2R1A,PTPN11
REAC:R-HSA-5684996	MAPK1/MAPK3 signaling	0.0000033901712047411876	0.0000033901712047411876	+1	KRAS,EGFR,NF1,FLT3,NRAS,BRAF,HGF,ERBB4,KIT,PDGFRA,FGFR2,FGFR3,PPP2R1A,PTPN11
REAC:R-HSA-190236	Signaling by FGFR	0.000003445084088117022	0.000003445084088117022	+1	PIK3CA,KRAS,PIK3R1,NRAS,BRAF,FGFR2,FGFR3,PPP2R1A,PTPN11
REAC:R-HSA-69231	Cyclin D associated events in G1	0.000004090584987070113	0.000004090584987070113	+1	CDKN2A,RB1,CDKN1B,CCND1,CDKN1A,PPP2R1A,CDKN2C
REAC:R-HSA-69236	G1 Phase	0.000004090584987070113	0.000004090584987070113	+1	CDKN2A,RB1,CDKN1B,CCND1,CDKN1A,PPP2R1A,CDKN2C
REAC:R-HSA-1640170	Cell Cycle	0.0000042677949484707105	0.0000042677949484707105	+1	TP53,CDKN2A,RB1,NPM1,AKT1,STAG2,AJUBA,ATM,CDKN1B,BRCA1,CHEK2,EP300,CCND1,BRCA2,CDKN1A,PPP2R1A,ATR,HIST1H2BD,SMC1A,SMC3,RAD21,CDKN2C
REAC:R-HSA-5637812	Signaling by EGFRvIII in Cancer	0.0000042677949484707105	0.0000042677949484707105	+1	PIK3CA,KRAS,EGFR,PIK3R1,NRAS
REAC:R-HSA-5637810	Constitutive Signaling by EGFRvIII	0.0000042677949484707105	0.0000042677949484707105	+1	PIK3CA,KRAS,EGFR,PIK3R1,NRAS
REAC:R-HSA-1236394	Signaling by ERBB4	0.0000043780582818320034	0.0000043780582818320034	+1	PIK3CA,KRAS,EGFR,PIK3R1,NRAS,ERBB4,NCOR1
REAC:R-HSA-8878166	Transcriptional regulation by RUNX2	0.0000045891981206899354	0.0000045891981206899354	+1	RB1,FBXW7,RUNX1,AKT1,AR,SOX9,CCND1,SMAD4,CDKN1A,CBFB
REAC:R-HSA-186763	Downstream signal transduction	0.000005339636275021724	0.000005339636275021724	+1	PIK3CA,KRAS,PIK3R1,NRAS,PDGFRA,PTPN11
REAC:R-HSA-5654696	Downstream signaling of activated FGFR2	0.000006483534758673623	0.000006483534758673623	+1	PIK3CA,KRAS,PIK3R1,NRAS,FGFR2,PTPN11
REAC:R-HSA-1227986	Signaling by ERBB2	0.000008329962068449469	0.000008329962068449469	+1	PIK3CA,KRAS,EGFR,PIK3R1,NRAS,AKT1,ERBB4
REAC:R-HSA-5654736	Signaling by FGFR1	0.000008329962068449469	0.000008329962068449469	+1	PIK3CA,KRAS,PIK3R1,NRAS,BRAF,PPP2R1A,PTPN11
REAC:R-HSA-5654738	Signaling by FGFR2	0.000008439828385515508	0.000008439828385515508	+1	PIK3CA,KRAS,PIK3R1,NRAS,BRAF,FGFR2,PPP2R1A,PTPN11
REAC:R-HSA-9006931	Signaling by Nuclear Receptors	0.00000848820835473598	0.00000848820835473598	+1	GATA3,RUNX1,STAG2,ERBB4,FOXA1,EP300,CCND1,CBFB,HIST1H2BD,SMC1A,SMC3,RAD21
REAC:R-HSA-210993	Tie2 Signaling	0.00000987391069993932	0.00000987391069993932	+1	PIK3CA,KRAS,PIK3R1,NRAS,PTPN11
REAC:R-HSA-5673001	RAF/MAP kinase cascade	0.000012100416866949188	0.000012100416866949188	+1	KRAS,EGFR,NF1,FLT3,NRAS,BRAF,HGF,ERBB4,KIT,PDGFRA,FGFR2,FGFR3,PPP2R1A
REAC:R-HSA-1643713	Signaling by EGFR in Cancer	0.000012362653779103654	0.000012362653779103654	+1	PIK3CA,KRAS,EGFR,PIK3R1,NRAS
REAC:R-HSA-5637815	Signaling by Ligand-Responsive EGFR Variants in Cancer	0.000012362653779103654	0.000012362653779103654	+1	PIK3CA,KRAS,EGFR,PIK3R1,NRAS
REAC:R-HSA-1236382	Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants	0.000012362653779103654	0.000012362653779103654	+1	PIK3CA,KRAS,EGFR,PIK3R1,NRAS
REAC:R-HSA-74752	Signaling by Insulin receptor	0.000012429933879289383	0.000012429933879289383	+1	PIK3CA,KRAS,PIK3R1,FLT3,NRAS,FGFR2,FGFR3,PTPN11
REAC:R-HSA-5683057	MAPK family signaling cascades	0.000014766086526219712	0.000014766086526219712	+1	KRAS,EGFR,NF1,FLT3,NRAS,BRAF,HGF,ERBB4,KIT,PDGFRA,FGFR2,FGFR3,PPP2R1A,PTPN11
REAC:R-HSA-2262752	Cellular responses to stress	0.00001656061811979635	0.00001656061811979635	+1	TP53,VHL,CDKN2A,RB1,MAP2K4,AR,AJUBA,ATM,CDKN1B,MTOR,HIST1H1C,EP300,CDKN1A,ATR,HIST1H2BD,CDKN2C,EZH2
REAC:R-HSA-2470946	Cohesin Loading onto Chromatin	0.000023466053222729116	0.000023466053222729116	+1	STAG2,SMC1A,SMC3,RAD21
REAC:R-HSA-5655332	Signaling by FGFR3 in disease	0.000024742792896463443	0.000024742792896463443	+1	PIK3CA,KRAS,PIK3R1,NRAS,FGFR3
REAC:R-HSA-8853338	Signaling by FGFR3 point mutants in cancer	0.000024742792896463443	0.000024742792896463443	+1	PIK3CA,KRAS,PIK3R1,NRAS,FGFR3
REAC:R-HSA-1500620	Meiosis	0.000030506393746335693	0.000030506393746335693	+1	STAG2,ATM,BRCA1,BRCA2,ATR,HIST1H2BD,SMC1A,SMC3,RAD21
REAC:R-HSA-5655291	Signaling by FGFR4 in disease	0.00003331871941886375	0.00003331871941886375	+1	PIK3CA,KRAS,PIK3R1,NRAS
REAC:R-HSA-180292	GAB1 signalosome	0.00003331871941886375	0.00003331871941886375	+1	PIK3CA,EGFR,PIK3R1,PTPN11
REAC:R-HSA-2468052	Establishment of Sister Chromatid Cohesion	0.00003331871941886375	0.00003331871941886375	+1	STAG2,SMC1A,SMC3,RAD21
REAC:R-HSA-2559583	Cellular Senescence	0.000038083073488597716	0.000038083073488597716	+1	TP53,CDKN2A,RB1,MAP2K4,ATM,CDKN1B,HIST1H1C,CDKN1A,HIST1H2BD,CDKN2C,EZH2
REAC:R-HSA-177929	Signaling by EGFR	0.000041150598399256305	0.000041150598399256305	+1	PIK3CA,KRAS,EGFR,PIK3R1,NRAS,PTPN11
REAC:R-HSA-1433557	Signaling by SCF-KIT	0.000041150598399256305	0.000041150598399256305	+1	PIK3CA,KRAS,PIK3R1,NRAS,KIT,PTPN11
REAC:R-HSA-6802953	RAS signaling downstream of NF1 loss-of-function variants	0.00004168709354030444	0.00004168709354030444	+1	KRAS,NF1,NRAS
REAC:R-HSA-9006115	Signaling by NTRK2 (TRKB)	0.000042080895863989746	0.000042080895863989746	+1	PIK3CA,KRAS,PIK3R1,NRAS,PTPN11
REAC:R-HSA-9006335	Signaling by Erythropoietin	0.000042080895863989746	0.000042080895863989746	+1	PIK3CA,KRAS,PIK3R1,NRAS,PIK3CG
REAC:R-HSA-1266738	Developmental Biology	0.00004341439561923835	0.00004341439561923835	+1	PIK3CA,KRAS,EGFR,PIK3R1,NOTCH1,CTNNB1,ARHGAP35,CTCF,NRAS,CEBPA,KDM6A,EPHA3,AKT1,AJUBA,EP300,EPHB6,SMAD4,FOXA2,HIST1H2BD,PTPN11,ACVR1B,TBL1XR1,ACVR2A,NCOR1,RPL5,SMAD2,EZH2
REAC:R-HSA-109704	PI3K Cascade	0.00004411844181154041	0.00004411844181154041	+1	PIK3CA,PIK3R1,FLT3,FGFR2,FGFR3,PTPN11
REAC:R-HSA-157118	Signaling by NOTCH	0.00005384336574330928	0.00005384336574330928	+1	TP53,EGFR,NOTCH1,FBXW7,RUNX1,AKT1,ELF3,EP300,CCND1,HIST1H2BD,TBL1XR1,NCOR1
REAC:R-HSA-5654716	Downstream signaling of activated FGFR4	0.000059677679350620915	0.000059677679350620915	+1	PIK3CA,KRAS,PIK3R1,NRAS,PTPN11
REAC:R-HSA-1502540	Signaling by Activin	0.00006107453671535248	0.00006107453671535248	+1	SMAD4,ACVR1B,ACVR2A,SMAD2
REAC:R-HSA-68884	Mitotic Telophase/Cytokinesis	0.0000837831603680399	0.0000837831603680399	+1	STAG2,SMC1A,SMC3,RAD21
REAC:R-HSA-8939247	RUNX1 regulates transcription of genes involved in interleukin signaling	0.00009182943292519572	0.00009182943292519572	+1	RUNX1,CBFB,LIFR
REAC:R-HSA-8953897	Cellular responses to external stimuli	0.00010456590200896746	0.00010456590200896746	+1	TP53,VHL,CDKN2A,RB1,MAP2K4,AR,AJUBA,ATM,CDKN1B,MTOR,HIST1H1C,EP300,CDKN1A,ATR,HIST1H2BD,CDKN2C,EZH2
REAC:R-HSA-5654687	Downstream signaling of activated FGFR1	0.00011430916429329652	0.00011430916429329652	+1	PIK3CA,KRAS,PIK3R1,NRAS,PTPN11
REAC:R-HSA-1221632	Meiotic synapsis	0.00011527748996981623	0.00011527748996981623	+1	STAG2,BRCA1,ATR,HIST1H2BD,SMC1A,SMC3,RAD21
REAC:R-HSA-1474165	Reproduction	0.00011786583200729288	0.00011786583200729288	+1	STAG2,ATM,BRCA1,BRCA2,ATR,HIST1H2BD,SMC1A,SMC3,RAD21
REAC:R-HSA-2559586	DNA Damage/Telomere Stress Induced Senescence	0.00012236968464206466	0.00012236968464206466	+1	TP53,RB1,ATM,CDKN1B,HIST1H1C,CDKN1A,HIST1H2BD
REAC:R-HSA-1963642	PI3K events in ERBB2 signaling	0.0001362405410370373	0.0001362405410370373	+1	PIK3CA,EGFR,PIK3R1,ERBB4
REAC:R-HSA-1963640	GRB2 events in ERBB2 signaling	0.0001362405410370373	0.0001362405410370373	+1	KRAS,EGFR,NRAS,ERBB4
REAC:R-HSA-8851907	MET activates PI3K/AKT signaling	0.00016576483664651655	0.00016576483664651655	+1	PIK3CA,PIK3R1,HGF
REAC:R-HSA-2559584	Formation of Senescence-Associated Heterochromatin Foci (SAHF)	0.00016904146798290764	0.00016904146798290764	+1	TP53,RB1,HIST1H1C,CDKN1A
REAC:R-HSA-9034015	Signaling by NTRK3 (TRKC)	0.00016904146798290764	0.00016904146798290764	+1	PIK3CA,KRAS,PIK3R1,NRAS
REAC:R-HSA-8934593	Regulation of RUNX1 Expression and Activity	0.00016904146798290764	0.00016904146798290764	+1	RUNX1,CCND1,CBFB,PTPN11
REAC:R-HSA-186797	Signaling by PDGF	0.00018446252220158401	0.00018446252220158401	+1	PIK3CA,KRAS,PIK3R1,NRAS,PDGFRA,PTPN11
REAC:R-HSA-8878171	Transcriptional regulation by RUNX1	0.00019236093727508297	0.00019236093727508297	+1	ARID1A,PBRM1,GATA3,RUNX1,EP300,CCND1,CBFB,SIN3A,HIST1H2BD,PTPN11,LIFR
REAC:R-HSA-5654710	PI-3K cascade:FGFR3	0.00020881204824286885	0.00020881204824286885	+1	PIK3CA,PIK3R1,FGFR3,PTPN11
REAC:R-HSA-8939243	RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known	0.0002390070307110727	0.0002390070307110727	+1	ARID1A,PBRM1,RUNX1,EP300,CBFB
REAC:R-HSA-69242	S Phase	0.0002390070307110727	0.0002390070307110727	+1	RB1,AKT1,STAG2,CDKN1B,CCND1,CDKN1A,SMC1A,SMC3,RAD21
REAC:R-HSA-6804760	Regulation of TP53 Activity through Methylation	0.00025093788824764505	0.00025093788824764505	+1	TP53,ATM,CHEK2,EP300
REAC:R-HSA-8941855	RUNX3 regulates CDKN1A transcription	0.00025093788824764505	0.00025093788824764505	+1	TP53,SMAD4,CDKN1A
REAC:R-HSA-3315487	SMAD2/3 MH2 Domain Mutants in Cancer	0.00025093788824764505	0.00025093788824764505	+1	SMAD4,TGFBR2,SMAD2
REAC:R-HSA-3304349	Loss of Function of SMAD2/3 in Cancer	0.00025093788824764505	0.00025093788824764505	+1	SMAD4,TGFBR2,SMAD2
REAC:R-HSA-179812	GRB2 events in EGFR signaling	0.00025093788824764505	0.00025093788824764505	+1	KRAS,EGFR,NRAS
REAC:R-HSA-6804756	Regulation of TP53 Activity through Phosphorylation	0.00025451907697311184	0.00025451907697311184	+1	TP53,STK11,ATM,BRCA1,CHEK2,TAF1,ATR
REAC:R-HSA-8864260	Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors	0.00025451907697311184	0.00025451907697311184	+1	EGFR,NPM1,KIT,EP300,CDKN1A
REAC:R-HSA-1226099	Signaling by FGFR in disease	0.0002632407393526068	0.0002632407393526068	+1	PIK3CA,KRAS,PIK3R1,NRAS,FGFR2,FGFR3
REAC:R-HSA-5693532	DNA Double-Strand Break Repair	0.00027738387820179684	0.00027738387820179684	+1	TP53,BAP1,ATM,BRCA1,POLQ,CHEK2,BRCA2,ATR,HIST1H2BD
REAC:R-HSA-5654706	FRS-mediated FGFR3 signaling	0.0002860770651461197	0.0002860770651461197	+1	KRAS,NRAS,FGFR3,PTPN11
REAC:R-HSA-1181150	Signaling by NODAL	0.0002860770651461197	0.0002860770651461197	+1	SMAD4,ACVR1B,ACVR2A,SMAD2
REAC:R-HSA-6796648	TP53 Regulates Transcription of DNA Repair Genes	0.00030329598600283225	0.00030329598600283225	+1	TP53,ATM,BRCA1,ATR,CDK12,ERCC2
REAC:R-HSA-69580	p53-Dependent G1/S DNA damage checkpoint	0.0003249647752613261	0.0003249647752613261	+1	TP53,CDKN2A,ATM,CDKN1B,CHEK2,CDKN1A
REAC:R-HSA-69563	p53-Dependent G1 DNA Damage Response	0.0003249647752613261	0.0003249647752613261	+1	TP53,CDKN2A,ATM,CDKN1B,CHEK2,CDKN1A
REAC:R-HSA-4420097	VEGFA-VEGFR2 Pathway	0.0003304863682890424	0.0003304863682890424	+1	PIK3CA,KRAS,PIK3R1,CTNNB1,NRAS,AKT1,MTOR
REAC:R-HSA-3304351	Signaling by TGF-beta Receptor Complex in Cancer	0.0003562910568888236	0.0003562910568888236	+1	SMAD4,TGFBR2,SMAD2
REAC:R-HSA-180336	SHC1 events in EGFR signaling	0.0003562910568888236	0.0003562910568888236	+1	KRAS,EGFR,NRAS
REAC:R-HSA-166520	Signaling by NTRKs	0.00036695961369398927	0.00036695961369398927	+1	PIK3CA,KRAS,PIK3R1,NRAS,BRAF,PPP2R1A,PTPN11
REAC:R-HSA-69615	G1/S DNA Damage Checkpoints	0.00036854129483626695	0.00036854129483626695	+1	TP53,CDKN2A,ATM,CDKN1B,CHEK2,CDKN1A
REAC:R-HSA-3769402	Deactivation of the beta-catenin transactivating complex	0.00037122361525800807	0.00037122361525800807	+1	APC,CTNNB1,AKT1,SOX9,SOX17
REAC:R-HSA-1250196	SHC1 events in ERBB2 signaling	0.0003825205601243484	0.0003825205601243484	+1	KRAS,EGFR,NRAS,ERBB4
REAC:R-HSA-389357	CD28 dependent PI3K/Akt signaling	0.0003825205601243484	0.0003825205601243484	+1	PIK3CA,PIK3R1,AKT1,MTOR
REAC:R-HSA-73894	DNA Repair	0.0003825205601243484	0.0003825205601243484	+1	TP53,BAP1,CRIPAK,ATM,BRCA1,POLQ,CHEK2,EP300,BRCA2,ATR,HIST1H2BD,ERCC2
REAC:R-HSA-5655253	Signaling by FGFR2 in disease	0.00040290804462000094	0.00040290804462000094	+1	PIK3CA,KRAS,PIK3R1,NRAS,FGFR2
REAC:R-HSA-388841	Costimulation by the CD28 family	0.000412970980902889	0.000412970980902889	+1	PIK3CA,PIK3R1,AKT1,MTOR,PPP2R1A,PTPN11
REAC:R-HSA-9006936	Signaling by TGF-beta family members	0.0004152159524468617	0.0004152159524468617	+1	SMAD4,USP9X,TGFBR2,ACVR1B,ACVR2A,NCOR1,SMAD2
REAC:R-HSA-5689880	Ub-specific processing proteases	0.0004197969306094106	0.0004197969306094106	+1	TP53,PTEN,GATA3,KEAP1,AR,SMAD4,USP9X,HIST1H2BD,SMAD2,AXIN2
REAC:R-HSA-69278	Cell Cycle, Mitotic	0.0004348371827563875	0.0004348371827563875	+1	TP53,CDKN2A,RB1,AKT1,STAG2,AJUBA,CDKN1B,EP300,CCND1,CDKN1A,PPP2R1A,HIST1H2BD,SMC1A,SMC3,RAD21,CDKN2C
REAC:R-HSA-2173795	Downregulation of SMAD2/3:SMAD4 transcriptional activity	0.0004348371827563875	0.0004348371827563875	+1	SMAD4,USP9X,NCOR1,SMAD2
REAC:R-HSA-5654695	PI-3K cascade:FGFR2	0.0004348371827563875	0.0004348371827563875	+1	PIK3CA,PIK3R1,FGFR2,PTPN11
REAC:R-HSA-1912408	Pre-NOTCH Transcription and Translation	0.00045151759201075484	0.00045151759201075484	+1	TP53,NOTCH1,RUNX1,ELF3,EP300,CCND1,HIST1H2BD
REAC:R-HSA-2179392	EGFR Transactivation by Gastrin	0.00046842677878711057	0.00046842677878711057	+1	KRAS,EGFR,NRAS
REAC:R-HSA-194138	Signaling by VEGF	0.00047245531990286693	0.00047245531990286693	+1	PIK3CA,KRAS,PIK3R1,CTNNB1,NRAS,AKT1,MTOR
REAC:R-HSA-2122947	NOTCH1 Intracellular Domain Regulates Transcription	0.0005744437104119761	0.0005744437104119761	+1	NOTCH1,FBXW7,EP300,TBL1XR1,NCOR1
REAC:R-HSA-5654700	FRS-mediated FGFR2 signaling	0.0005829507052168159	0.0005829507052168159	+1	KRAS,NRAS,FGFR2,PTPN11
REAC:R-HSA-5673000	RAF activation	0.0005829507052168159	0.0005829507052168159	+1	KRAS,NRAS,BRAF,PPP2R1A
REAC:R-HSA-5693565	Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks	0.0005928216399680811	0.0005928216399680811	+1	TP53,BAP1,ATM,BRCA1,CHEK2,HIST1H2BD
REAC:R-HSA-3108214	SUMOylation of DNA damage response and repair proteins	0.0005928216399680811	0.0005928216399680811	+1	CDKN2A,STAG2,BRCA1,SMC1A,SMC3,RAD21
REAC:R-HSA-212165	Epigenetic regulation of gene expression	0.0006081942564096199	0.0006081942564096199	+1	DNMT3A,TET2,EP300,SF3B1,SIN3A,HIST1H2BD,ERCC2,EZH2
REAC:R-HSA-1250342	PI3K events in ERBB4 signaling	0.0006234793421008649	0.0006234793421008649	+1	PIK3CA,PIK3R1,ERBB4
REAC:R-HSA-453279	Mitotic G1-G1/S phases	0.0006234793421008649	0.0006234793421008649	+1	CDKN2A,RB1,AKT1,CDKN1B,CCND1,CDKN1A,PPP2R1A,CDKN2C
REAC:R-HSA-5693606	DNA Double Strand Break Response	0.0006234793421008649	0.0006234793421008649	+1	TP53,BAP1,ATM,BRCA1,CHEK2,HIST1H2BD
REAC:R-HSA-6785807	Interleukin-4 and Interleukin-13 signaling	0.0006234793421008649	0.0006234793421008649	+1	TP53,PIK3R1,GATA3,AKT1,HGF,CCND1,CDKN1A
REAC:R-HSA-5674400	Constitutive Signaling by AKT1 E17K in Cancer	0.0006446728005094372	0.0006446728005094372	+1	AKT1,CDKN1B,MTOR,CDKN1A
REAC:R-HSA-6791312	TP53 Regulates Transcription of Cell Cycle Genes	0.0006468971675351258	0.0006468971675351258	+1	TP53,NPM1,CDKN1B,EP300,CDKN1A
REAC:R-HSA-187037	Signaling by NTRK1 (TRKA)	0.0006468971675351258	0.0006468971675351258	+1	PIK3CA,KRAS,PIK3R1,NRAS,BRAF,PPP2R1A
REAC:R-HSA-6806834	Signaling by MET	0.0006896718301948517	0.0006896718301948517	+1	PIK3CA,KRAS,PIK3R1,NRAS,HGF,PTPN11
REAC:R-HSA-8851805	MET activates RAS signaling	0.0008006567046752276	0.0008006567046752276	+1	KRAS,NRAS,HGF
REAC:R-HSA-9028731	Activated NTRK2 signals through FRS2 and FRS3	0.0008006567046752276	0.0008006567046752276	+1	KRAS,NRAS,PTPN11
REAC:R-HSA-2424491	DAP12 signaling	0.000833914796598896	0.000833914796598896	+1	PIK3CA,KRAS,PIK3R1,NRAS
REAC:R-HSA-5654732	Negative regulation of FGFR3 signaling	0.0009535175192420341	0.0009535175192420341	+1	BRAF,FGFR3,PPP2R1A,PTPN11
REAC:R-HSA-1912422	Pre-NOTCH Expression and Processing	0.0009540940974106717	0.0009540940974106717	+1	TP53,NOTCH1,RUNX1,ELF3,EP300,CCND1,HIST1H2BD
REAC:R-HSA-9027276	Erythropoietin activates Phosphoinositide-3-kinase (PI3K)	0.0010314490148258585	0.0010314490148258585	+1	PIK3CA,PIK3R1,PIK3CG
REAC:R-HSA-5619507	Activation of HOX genes during differentiation	0.0010362020562786581	0.0010362020562786581	+1	CTCF,KDM6A,AJUBA,EP300,HIST1H2BD,NCOR1,EZH2
REAC:R-HSA-5617472	Activation of anterior HOX genes in hindbrain development during early embryogenesis	0.0010362020562786581	0.0010362020562786581	+1	CTCF,KDM6A,AJUBA,EP300,HIST1H2BD,NCOR1,EZH2
REAC:R-HSA-8941326	RUNX2 regulates bone development	0.0012033107128363622	0.0012033107128363622	+1	RB1,AR,SMAD4,CBFB
REAC:R-HSA-9005895	Pervasive developmental disorders	0.0012876848570418267	0.0012876848570418267	+1	SIN3A,TBL1XR1,NCOR1
REAC:R-HSA-9005891	Loss of function of MECP2 in Rett syndrome	0.0012876848570418267	0.0012876848570418267	+1	SIN3A,TBL1XR1,NCOR1
REAC:R-HSA-2644602	Signaling by NOTCH1 PEST Domain Mutants in Cancer	0.0012876848570418267	0.0012876848570418267	+1	NOTCH1,FBXW7,EP300,TBL1XR1,NCOR1
REAC:R-HSA-2894858	Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer	0.0012876848570418267	0.0012876848570418267	+1	NOTCH1,FBXW7,EP300,TBL1XR1,NCOR1
REAC:R-HSA-2894862	Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants	0.0012876848570418267	0.0012876848570418267	+1	NOTCH1,FBXW7,EP300,TBL1XR1,NCOR1
REAC:R-HSA-2644603	Signaling by NOTCH1 in Cancer	0.0012876848570418267	0.0012876848570418267	+1	NOTCH1,FBXW7,EP300,TBL1XR1,NCOR1
REAC:R-HSA-2644606	Constitutive Signaling by NOTCH1 PEST Domain Mutants	0.0012876848570418267	0.0012876848570418267	+1	NOTCH1,FBXW7,EP300,TBL1XR1,NCOR1
REAC:R-HSA-8951911	RUNX3 regulates RUNX1-mediated transcription	0.001418681612904724	0.001418681612904724	+1	RUNX1,CBFB
REAC:R-HSA-3311021	SMAD4 MH2 Domain Mutants in Cancer	0.001418681612904724	0.001418681612904724	+1	SMAD4,SMAD2
REAC:R-HSA-3304347	Loss of Function of SMAD4 in Cancer	0.001418681612904724	0.001418681612904724	+1	SMAD4,SMAD2
REAC:R-HSA-389356	CD28 co-stimulation	0.0014373899122333714	0.0014373899122333714	+1	PIK3CA,PIK3R1,AKT1,MTOR
REAC:R-HSA-198323	AKT phosphorylates targets in the cytosol	0.0015009356620411518	0.0015009356620411518	+1	AKT1,CDKN1B,CDKN1A
REAC:R-HSA-6804116	TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest	0.0015009356620411518	0.0015009356620411518	+1	TP53,CDKN1B,CDKN1A
REAC:R-HSA-1250347	SHC1 events in ERBB4 signaling	0.0015009356620411518	0.0015009356620411518	+1	KRAS,NRAS,ERBB4
REAC:R-HSA-8849471	PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases	0.0015009356620411518	0.0015009356620411518	+1	KRAS,ARHGAP35,NRAS
REAC:R-HSA-8943724	Regulation of PTEN gene transcription	0.0015457567410983428	0.0015457567410983428	+1	TP53,PTEN,MTOR,MECOM,EZH2
REAC:R-HSA-5654727	Negative regulation of FGFR2 signaling	0.0015502034250889217	0.0015502034250889217	+1	BRAF,FGFR2,PPP2R1A,PTPN11
REAC:R-HSA-2559585	Oncogene Induced Senescence	0.0015502034250889217	0.0015502034250889217	+1	TP53,CDKN2A,RB1,CDKN2C
REAC:R-HSA-69473	G2/M DNA damage checkpoint	0.001588302720950307	0.001588302720950307	+1	TP53,ATM,BRCA1,CHEK2,ATR,HIST1H2BD
REAC:R-HSA-114604	GPVI-mediated activation cascade	0.001716857030667015	0.001716857030667015	+1	PIK3CA,PIK3R1,PIK3CG,PTPN11
REAC:R-HSA-5358749	S37 mutants of beta-catenin aren't phosphorylated	0.0017378824457494658	0.0017378824457494658	+1	APC,CTNNB1,PPP2R1A
REAC:R-HSA-5358747	S33 mutants of beta-catenin aren't phosphorylated	0.0017378824457494658	0.0017378824457494658	+1	APC,CTNNB1,PPP2R1A
REAC:R-HSA-4839743	phosphorylation site mutants of CTNNB1 are not targeted to the proteasome by the destruction complex	0.0017378824457494658	0.0017378824457494658	+1	APC,CTNNB1,PPP2R1A
REAC:R-HSA-5358752	T41 mutants of beta-catenin aren't phosphorylated	0.0017378824457494658	0.0017378824457494658	+1	APC,CTNNB1,PPP2R1A
REAC:R-HSA-5339716	Misspliced GSK3beta mutants stabilize beta-catenin	0.0017378824457494658	0.0017378824457494658	+1	APC,CTNNB1,PPP2R1A
REAC:R-HSA-5358751	S45 mutants of beta-catenin aren't phosphorylated	0.0017378824457494658	0.0017378824457494658	+1	APC,CTNNB1,PPP2R1A
REAC:R-HSA-8986944	Transcriptional Regulation by MECP2	0.0017378824457494658	0.0017378824457494658	+1	PTEN,NOTCH1,SIN3A,TBL1XR1,NCOR1
REAC:R-HSA-2172127	DAP12 interactions	0.001831732588128394	0.001831732588128394	+1	PIK3CA,KRAS,PIK3R1,NRAS
REAC:R-HSA-1295596	Spry regulation of FGF signaling	0.002100185526313559	0.002100185526313559	+1	BRAF,PPP2R1A,PTPN11
REAC:R-HSA-201681	TCF dependent signaling in response to WNT	0.0021591397793018336	0.0021591397793018336	+1	APC,CTNNB1,AKT1,SOX9,EP300,SOX17,PPP2R1A,HIST1H2BD,AXIN2
REAC:R-HSA-5655302	Signaling by FGFR1 in disease	0.0022239114941160452	0.0022239114941160452	+1	PIK3CA,KRAS,PIK3R1,NRAS
REAC:R-HSA-597592	Post-translational protein modification	0.002265348198159699	0.002265348198159699	+1	TP53,PTEN,APC,VHL,CDKN2A,GATA3,FBXW7,DNMT3A,KEAP1,BAP1,NPM1,STAG2,AR,BRCA1,EP300,SMAD4,USP9X,ASXL1,TGFBR2,B4GALT3,SIN3A,HIST1H2BD,SMC1A,SMC3,SMAD2,AXIN2,RAD21
REAC:R-HSA-196299	Beta-catenin phosphorylation cascade	0.0024248384518924734	0.0024248384518924734	+1	APC,CTNNB1,PPP2R1A
REAC:R-HSA-69895	Transcriptional  activation of  cell cycle inhibitor p21 	0.0024248384518924734	0.0024248384518924734	+1	TP53,CDKN1A
REAC:R-HSA-8941333	RUNX2 regulates genes involved in differentiation of myeloid cells	0.0024248384518924734	0.0024248384518924734	+1	RUNX1,CBFB
REAC:R-HSA-69560	Transcriptional activation of p53 responsive genes  	0.0024248384518924734	0.0024248384518924734	+1	TP53,CDKN1A
REAC:R-HSA-5693616	Presynaptic phase of homologous DNA pairing and strand exchange	0.0024248384518924734	0.0024248384518924734	+1	ATM,BRCA1,BRCA2,ATR
REAC:R-HSA-69620	Cell Cycle Checkpoints	0.0024362238233241345	0.0024362238233241345	+1	TP53,CDKN2A,ATM,CDKN1B,BRCA1,CHEK2,CDKN1A,PPP2R1A,ATR,HIST1H2BD
REAC:R-HSA-449147	Signaling by Interleukins	0.0024729934333750643	0.0024729934333750643	+1	TP53,PIK3CA,PIK3R1,GATA3,FLT3,MAP2K4,AKT1,HGF,CCND1,CDKN1A,PPP2R1A,PTPN11,LIFR
REAC:R-HSA-5675221	Negative regulation of MAPK pathway	0.0025850350587438946	0.0025850350587438946	+1	KRAS,NRAS,BRAF,PPP2R1A
REAC:R-HSA-5654704	SHC-mediated cascade:FGFR3	0.002814575744238381	0.002814575744238381	+1	KRAS,NRAS,FGFR3
REAC:R-HSA-881907	Gastrin-CREB signalling pathway via PKC and MAPK	0.002814575744238381	0.002814575744238381	+1	KRAS,EGFR,NRAS
REAC:R-HSA-1980143	Signaling by NOTCH1	0.0030241185982352674	0.0030241185982352674	+1	NOTCH1,FBXW7,EP300,TBL1XR1,NCOR1
REAC:R-HSA-5693579	Homologous DNA Pairing and Strand Exchange	0.0030241185982352674	0.0030241185982352674	+1	ATM,BRCA1,BRCA2,ATR
REAC:R-HSA-170834	Signaling by TGF-beta Receptor Complex	0.0030241185982352674	0.0030241185982352674	+1	SMAD4,USP9X,TGFBR2,NCOR1,SMAD2
REAC:R-HSA-186712	Regulation of beta-cell development	0.0030241185982352674	0.0030241185982352674	+1	NOTCH1,AKT1,EP300,FOXA2
REAC:R-HSA-2173793	Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer	0.003594673865012473	0.003594673865012473	+1	SMAD4,USP9X,NCOR1,SMAD2
REAC:R-HSA-8935964	RUNX1 regulates expression of components of tight junctions	0.0036711530508589216	0.0036711530508589216	+1	RUNX1,CBFB
REAC:R-HSA-5654720	PI-3K cascade:FGFR4	0.0036711530508589216	0.0036711530508589216	+1	PIK3CA,PIK3R1,PTPN11
REAC:R-HSA-3134973	LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production	0.0036711530508589216	0.0036711530508589216	+1	CTNNB1,EP300
REAC:R-HSA-1169092	Activation of RAS in B cells	0.0036711530508589216	0.0036711530508589216	+1	KRAS,NRAS
REAC:R-HSA-2644607	Loss of Function of FBXW7 in Cancer and NOTCH1 Signaling	0.0036711530508589216	0.0036711530508589216	+1	NOTCH1,FBXW7
REAC:R-HSA-8865999	MET activates PTPN11	0.0036711530508589216	0.0036711530508589216	+1	HGF,PTPN11
REAC:R-HSA-2644605	FBXW7 Mutants and NOTCH1 in Cancer	0.0036711530508589216	0.0036711530508589216	+1	NOTCH1,FBXW7
REAC:R-HSA-5621575	CD209 (DC-SIGN) signaling	0.004167774673748055	0.004167774673748055	+1	KRAS,NRAS,EP300
REAC:R-HSA-5654689	PI-3K cascade:FGFR1	0.004167774673748055	0.004167774673748055	+1	PIK3CA,PIK3R1,PTPN11
REAC:R-HSA-389513	CTLA4 inhibitory signaling	0.004167774673748055	0.004167774673748055	+1	AKT1,PPP2R1A,PTPN11
REAC:R-HSA-5654712	FRS-mediated FGFR4 signaling	0.00476863862404239	0.00476863862404239	+1	KRAS,NRAS,PTPN11
REAC:R-HSA-69202	Cyclin E associated events during G1/S transition 	0.0050628277514808626	0.0050628277514808626	+1	RB1,AKT1,CDKN1B,CCND1,CDKN1A
REAC:R-HSA-3304356	SMAD2/3 Phosphorylation Motif Mutants in Cancer	0.005146541734716709	0.005146541734716709	+1	TGFBR2,SMAD2
REAC:R-HSA-109581	Apoptosis	0.005146541734716709	0.005146541734716709	+1	TP53,APC,CTNNB1,CDH1,AKT1,TLR4,HIST1H1C
REAC:R-HSA-9603381	Activated NTRK3 signals through PI3K	0.005146541734716709	0.005146541734716709	+1	PIK3CA,PIK3R1
REAC:R-HSA-8939256	RUNX1 regulates transcription of genes involved in WNT signaling	0.005146541734716709	0.005146541734716709	+1	RUNX1,CBFB
REAC:R-HSA-8939245	RUNX1 regulates transcription of genes involved in BCR signaling	0.005146541734716709	0.005146541734716709	+1	RUNX1,CBFB
REAC:R-HSA-8849470	PTK6 Regulates Cell Cycle	0.005146541734716709	0.005146541734716709	+1	CDKN1B,CCND1
REAC:R-HSA-8857538	PTK6 promotes HIF1A stabilization	0.005146541734716709	0.005146541734716709	+1	EGFR,LRRK2
REAC:R-HSA-8931987	RUNX1 regulates estrogen receptor mediated transcription	0.005146541734716709	0.005146541734716709	+1	RUNX1,CBFB
REAC:R-HSA-5654693	FRS-mediated FGFR1 signaling	0.0051738605054613765	0.0051738605054613765	+1	KRAS,NRAS,PTPN11
REAC:R-HSA-5654699	SHC-mediated cascade:FGFR2	0.0051738605054613765	0.0051738605054613765	+1	KRAS,NRAS,FGFR2
REAC:R-HSA-2559580	Oxidative Stress Induced Senescence	0.005207545994705773	0.005207545994705773	+1	TP53,CDKN2A,MAP2K4,HIST1H2BD,CDKN2C,EZH2
REAC:R-HSA-69656	Cyclin A:Cdk2-associated events at S phase entry	0.00532866010383396	0.00532866010383396	+1	RB1,AKT1,CDKN1B,CCND1,CDKN1A
REAC:R-HSA-5357801	Programmed Cell Death	0.005454768627530248	0.005454768627530248	+1	TP53,APC,CTNNB1,CDH1,AKT1,TLR4,HIST1H1C
REAC:R-HSA-8940973	RUNX2 regulates osteoblast differentiation	0.005766511933077823	0.005766511933077823	+1	RB1,AR,CBFB
REAC:R-HSA-75153	Apoptotic execution phase	0.005943373582398355	0.005943373582398355	+1	APC,CTNNB1,CDH1,HIST1H1C
REAC:R-HSA-6802949	Signaling by RAS mutants	0.006324422635609345	0.006324422635609345	+1	KRAS,NF1,NRAS,BRAF
REAC:R-HSA-1660499	Synthesis of PIPs at the plasma membrane	0.006324422635609345	0.006324422635609345	+1	PIK3CA,PTEN,PIK3R1,PIK3CG
REAC:R-HSA-69206	G1/S Transition	0.006415080512133755	0.006415080512133755	+1	RB1,AKT1,CDKN1B,CCND1,CDKN1A,PPP2R1A
REAC:R-HSA-112412	SOS-mediated signalling	0.006671454490123141	0.006671454490123141	+1	KRAS,NRAS
REAC:R-HSA-3656534	Loss of Function of TGFBR1 in Cancer	0.006671454490123141	0.006671454490123141	+1	TGFBR2,SMAD2
REAC:R-HSA-9028335	Activated NTRK2 signals through PI3K	0.006671454490123141	0.006671454490123141	+1	PIK3CA,PIK3R1
REAC:R-HSA-9022537	Loss of MECP2 binding ability to the NCoR/SMRT complex	0.006671454490123141	0.006671454490123141	+1	TBL1XR1,NCOR1
REAC:R-HSA-8939246	RUNX1 regulates transcription of genes involved in differentiation of myeloid cells	0.006671454490123141	0.006671454490123141	+1	RUNX1,CBFB
REAC:R-HSA-3656532	TGFBR1 KD Mutants in Cancer	0.006671454490123141	0.006671454490123141	+1	TGFBR2,SMAD2
REAC:R-HSA-5693554	Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA)	0.00696216196384917	0.00696216196384917	+1	ATM,BRCA1,BRCA2
REAC:R-HSA-5218920	VEGFR2 mediated vascular permeability	0.007743924367026107	0.007743924367026107	+1	CTNNB1,AKT1,MTOR
REAC:R-HSA-69541	Stabilization of p53	0.007930957999574382	0.007930957999574382	+1	TP53,CDKN2A,ATM,CHEK2
REAC:R-HSA-5693538	Homology Directed Repair	0.007996453395018923	0.007996453395018923	+1	ATM,BRCA1,POLQ,BRCA2,ATR,HIST1H2BD
REAC:R-HSA-6807070	PTEN Regulation	0.008257013170450436	0.008257013170450436	+1	TP53,PTEN,AKT1,MTOR,MECOM,EZH2
REAC:R-HSA-8941332	RUNX2 regulates genes involved in cell migration	0.008477423579982754	0.008477423579982754	+1	AKT1,CBFB
REAC:R-HSA-9034864	Activated NTRK3 signals through RAS	0.008477423579982754	0.008477423579982754	+1	KRAS,NRAS
REAC:R-HSA-4411364	Binding of TCF/LEF:CTNNB1 to target gene promoters	0.008477423579982754	0.008477423579982754	+1	CTNNB1,AXIN2
REAC:R-HSA-8951430	RUNX3 regulates WNT signaling	0.008477423579982754	0.008477423579982754	+1	CTNNB1,CCND1
REAC:R-HSA-8939242	RUNX1 regulates transcription of genes involved in differentiation of keratinocytes	0.008477423579982754	0.008477423579982754	+1	RUNX1,CBFB
REAC:R-HSA-8936459	RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function	0.009043245521741223	0.009043245521741223	+1	RUNX1,EP300,CBFB,SIN3A,HIST1H2BD
REAC:R-HSA-8863795	Downregulation of ERBB2 signaling	0.009150836901226554	0.009150836901226554	+1	EGFR,AKT1,ERBB4
REAC:R-HSA-187687	Signalling to ERKs	0.010014303823977633	0.010014303823977633	+1	KRAS,NRAS,BRAF
REAC:R-HSA-6804758	Regulation of TP53 Activity through Acetylation	0.010014303823977633	0.010014303823977633	+1	TP53,AKT1,EP300
REAC:R-HSA-8876493	InlA-mediated entry of Listeria monocytogenes into host cells	0.010445895240996879	0.010445895240996879	+1	CTNNB1,CDH1
REAC:R-HSA-6811555	PI5P Regulates TP53 Acetylation	0.010445895240996879	0.010445895240996879	+1	TP53,EP300
REAC:R-HSA-198203	PI3K/AKT activation	0.010445895240996879	0.010445895240996879	+1	PIK3CA,PIK3R1
REAC:R-HSA-9026519	Activated NTRK2 signals through RAS	0.010445895240996879	0.010445895240996879	+1	KRAS,NRAS
REAC:R-HSA-2428933	SHC-related events triggered by IGF1R	0.010445895240996879	0.010445895240996879	+1	KRAS,NRAS
REAC:R-HSA-5654733	Negative regulation of FGFR4 signaling	0.010707547646795476	0.010707547646795476	+1	BRAF,PPP2R1A,PTPN11
REAC:R-HSA-4641262	Disassembly of the destruction complex and recruitment of AXIN to the membrane	0.010707547646795476	0.010707547646795476	+1	APC,CTNNB1,PPP2R1A
REAC:R-HSA-2173789	TGF-beta receptor signaling activates SMADs	0.011640451417960718	0.011640451417960718	+1	SMAD4,TGFBR2,SMAD2
REAC:R-HSA-9022692	Regulation of MECP2 expression and activity	0.011640451417960718	0.011640451417960718	+1	SIN3A,TBL1XR1,NCOR1
REAC:R-HSA-5654726	Negative regulation of FGFR1 signaling	0.012615887141722492	0.012615887141722492	+1	BRAF,PPP2R1A,PTPN11
REAC:R-HSA-5693568	Resolution of D-loop Structures through Holliday Junction Intermediates	0.012615887141722492	0.012615887141722492	+1	ATM,BRCA1,BRCA2
REAC:R-HSA-8877330	RUNX1 and FOXP3 control the development of regulatory T lymphocytes (Tregs)	0.012625713834613375	0.012625713834613375	+1	RUNX1,CBFB
REAC:R-HSA-5685942	HDR through Homologous Recombination (HRR)	0.01296956770473381	0.01296956770473381	+1	ATM,BRCA1,BRCA2,ATR
REAC:R-HSA-4791275	Signaling by WNT in cancer	0.013530527686465205	0.013530527686465205	+1	APC,CTNNB1,PPP2R1A
REAC:R-HSA-5693537	Resolution of D-Loop Structures	0.013530527686465205	0.013530527686465205	+1	ATM,BRCA1,BRCA2
REAC:R-HSA-2559582	Senescence-Associated Secretory Phenotype (SASP)	0.013790363340626251	0.013790363340626251	+1	CDKN2A,CDKN1B,CDKN1A,HIST1H2BD,CDKN2C
REAC:R-HSA-1433617	Regulation of signaling by NODAL	0.014988029119774947	0.014988029119774947	+1	ACVR1B,ACVR2A
REAC:R-HSA-351906	Apoptotic cleavage of cell adhesion  proteins	0.014988029119774947	0.014988029119774947	+1	CTNNB1,CDH1
REAC:R-HSA-195721	Signaling by WNT	0.015249771413643134	0.015249771413643134	+1	APC,CTNNB1,AKT1,SOX9,EP300,SOX17,PPP2R1A,HIST1H2BD,AXIN2
REAC:R-HSA-3214841	PKMTs methylate histone lysines	0.015540873950799361	0.015540873950799361	+1	SETD2,NSD1,MECOM,EZH2
REAC:R-HSA-6802948	Signaling by high-kinase activity BRAF mutants	0.015562745701112725	0.015562745701112725	+1	KRAS,NRAS,BRAF
REAC:R-HSA-5685938	HDR through Single Strand Annealing (SSA)	0.016753976801686526	0.016753976801686526	+1	ATM,BRCA1,ATR
REAC:R-HSA-6803207	TP53 Regulates Transcription of Caspase Activators and Caspases	0.017542012313728216	0.017542012313728216	+1	TP53,ATM
REAC:R-HSA-111465	Apoptotic cleavage of cellular proteins	0.017863558466475304	0.017863558466475304	+1	APC,CTNNB1,CDH1
REAC:R-HSA-5689896	Ovarian tumor domain proteases	0.017863558466475304	0.017863558466475304	+1	TP53,PTEN,APC
REAC:R-HSA-69481	G2/M Checkpoints	0.018224689115776013	0.018224689115776013	+1	TP53,ATM,BRCA1,CHEK2,ATR,HIST1H2BD
REAC:R-HSA-6802957	Oncogenic MAPK signaling	0.019266515233186225	0.019266515233186225	+1	KRAS,NF1,NRAS,BRAF
REAC:R-HSA-8847993	ERBB2 Activates PTK6 Signaling	0.019900147118518705	0.019900147118518705	+1	EGFR,ERBB4
REAC:R-HSA-6802946	Signaling by moderate kinase activity BRAF mutants	0.019900147118518705	0.019900147118518705	+1	KRAS,NRAS,BRAF
REAC:R-HSA-113501	Inhibition of replication initiation of damaged DNA by RB1/E2F1	0.019900147118518705	0.019900147118518705	+1	RB1,PPP2R1A
REAC:R-HSA-171007	p38MAPK events	0.019900147118518705	0.019900147118518705	+1	KRAS,NRAS
REAC:R-HSA-8853659	RET signaling	0.019900147118518705	0.019900147118518705	+1	PIK3CA,PIK3R1,PTPN11
REAC:R-HSA-6802955	Paradoxical activation of RAF signaling by kinase inactive BRAF	0.019900147118518705	0.019900147118518705	+1	KRAS,NRAS,BRAF
REAC:R-HSA-5674135	MAP2K and MAPK activation	0.019900147118518705	0.019900147118518705	+1	KRAS,NRAS,BRAF
REAC:R-HSA-165159	mTOR signalling	0.019900147118518705	0.019900147118518705	+1	STK11,AKT1,MTOR
REAC:R-HSA-1280215	Cytokine Signaling in Immune system	0.021100679710405804	0.021100679710405804	+1	TP53,PIK3CA,PIK3R1,GATA3,FLT3,MAP2K4,AKT1,HGF,CCND1,CDKN1A,PPP2R1A,EIF4A2,PTPN11,LIFR
REAC:R-HSA-3214858	RMTs methylate histone arginines	0.021291973976584336	0.021291973976584336	+1	ARID1A,PBRM1,DNMT3A,CCND1
REAC:R-HSA-2500257	Resolution of Sister Chromatid Cohesion	0.021737615457590554	0.021737615457590554	+1	STAG2,PPP2R1A,SMC1A,SMC3,RAD21
REAC:R-HSA-5467348	Truncations of AMER1 destabilize the destruction complex	0.021942342063782507	0.021942342063782507	+1	APC,PPP2R1A
REAC:R-HSA-9027284	Erythropoietin activates RAS	0.021942342063782507	0.021942342063782507	+1	KRAS,NRAS
REAC:R-HSA-8941856	RUNX3 regulates NOTCH signaling	0.021942342063782507	0.021942342063782507	+1	NOTCH1,EP300
REAC:R-HSA-4839748	AMER1 mutants destabilize the destruction complex	0.021942342063782507	0.021942342063782507	+1	APC,PPP2R1A
REAC:R-HSA-5467337	APC truncation mutants have impaired AXIN binding	0.021942342063782507	0.021942342063782507	+1	APC,PPP2R1A
REAC:R-HSA-5467340	AXIN missense mutants destabilize the destruction complex	0.021942342063782507	0.021942342063782507	+1	APC,PPP2R1A
REAC:R-HSA-6804759	Regulation of TP53 Activity through Association with Co-factors	0.021942342063782507	0.021942342063782507	+1	TP53,AKT1
REAC:R-HSA-4839735	AXIN mutants destabilize the destruction complex, activating WNT signaling	0.021942342063782507	0.021942342063782507	+1	APC,PPP2R1A
REAC:R-HSA-4839744	truncated APC mutants destabilize the destruction complex	0.021942342063782507	0.021942342063782507	+1	APC,PPP2R1A
REAC:R-HSA-166016	Toll Like Receptor 4 (TLR4) Cascade	0.023155509214117957	0.023155509214117957	+1	MAP3K1,MAP2K4,TLR4,PPP2R1A,PTPN11
REAC:R-HSA-9013694	Signaling by NOTCH4	0.023183686493601648	0.023183686493601648	+1	NOTCH1,FBXW7,AKT1,EP300
REAC:R-HSA-3899300	SUMOylation of transcription cofactors	0.023183686493601648	0.023183686493601648	+1	NPM1,EP300,SIN3A
REAC:R-HSA-1500931	Cell-Cell communication	0.024423979373201475	0.024423979373201475	+1	PIK3CA,PIK3R1,CTNNB1,CDH1,PTPN11
REAC:R-HSA-6785631	ERBB2 Regulates Cell Motility	0.024656606430875215	0.024656606430875215	+1	EGFR,ERBB4
REAC:R-HSA-8866910	TFAP2 (AP-2) family regulates transcription of growth factors and their receptors	0.024656606430875215	0.024656606430875215	+1	EGFR,KIT
REAC:R-HSA-1483255	PI Metabolism	0.024701320667883043	0.024701320667883043	+1	PIK3CA,PTEN,PIK3R1,PIK3CG
REAC:R-HSA-195253	Degradation of beta-catenin by the destruction complex	0.024701320667883043	0.024701320667883043	+1	APC,CTNNB1,PPP2R1A,AXIN2
REAC:R-HSA-381340	Transcriptional regulation of white adipocyte differentiation	0.024701320667883043	0.024701320667883043	+1	CEBPA,EP300,TBL1XR1,NCOR1
REAC:R-HSA-389542	NADPH regeneration	0.025243153832457958	0.025243153832457958	+1	IDH1
REAC:R-HSA-5674404	PTEN Loss of Function in Cancer	0.025243153832457958	0.025243153832457958	+1	PTEN
REAC:R-HSA-2023837	Signaling by FGFR2 amplification mutants	0.025243153832457958	0.025243153832457958	+1	FGFR2
REAC:R-HSA-8853333	Signaling by FGFR2 fusions	0.025243153832457958	0.025243153832457958	+1	FGFR2
REAC:R-HSA-2978092	Abnormal conversion of 2-oxoglutarate to 2-hydroxyglutarate	0.025243153832457958	0.025243153832457958	+1	IDH1
REAC:R-HSA-5467333	APC truncation mutants are not K63 polyubiquitinated	0.025243153832457958	0.025243153832457958	+1	APC
REAC:R-HSA-5693567	HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA)	0.025243153832457958	0.025243153832457958	+1	ATM,BRCA1,BRCA2,ATR,HIST1H2BD
REAC:R-HSA-2033515	t(4;14) translocations of FGFR3	0.025243153832457958	0.025243153832457958	+1	FGFR3
REAC:R-HSA-2454202	Fc epsilon receptor (FCERI) signaling	0.025752319914668934	0.025752319914668934	+1	PIK3CA,KRAS,PIK3R1,MAP3K1,NRAS,MAP2K4
REAC:R-HSA-912446	Meiotic recombination	0.026726919603355753	0.026726919603355753	+1	ATM,BRCA1,BRCA2,HIST1H2BD
REAC:R-HSA-210744	Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells	0.026726919603355753	0.026726919603355753	+1	NOTCH1,EP300
REAC:R-HSA-2871796	FCERI mediated MAPK activation	0.026726919603355753	0.026726919603355753	+1	KRAS,MAP3K1,NRAS,MAP2K4
REAC:R-HSA-5628897	TP53 Regulates Metabolic Genes	0.026726919603355753	0.026726919603355753	+1	TP53,PTEN,AKT1,MTOR
REAC:R-HSA-512988	Interleukin-3, Interleukin-5 and GM-CSF signaling	0.02930699076025917	0.02930699076025917	+1	PIK3CA,PIK3R1,PTPN11
REAC:R-HSA-432142	Platelet sensitization by LDL	0.029619150032800794	0.029619150032800794	+1	PPP2R1A,PTPN11
REAC:R-HSA-936964	Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon	0.029619150032800794	0.029619150032800794	+1	TLR4,PTPN11
REAC:R-HSA-392499	Metabolism of proteins	0.029619150032800794	0.029619150032800794	+1	TP53,PTEN,APC,VHL,CDKN2A,GATA3,FBXW7,CTNNB1,DNMT3A,KEAP1,BAP1,NPM1,STAG2,AR,BRCA1,EP300,SMAD4,USP9X,ASXL1,TGFBR2,B4GALT3,SIN3A,HIST1H2BD,EIF4A2,SMC1A,SMC3,RPL5,SMAD2,AXIN2,RAD21
REAC:R-HSA-9012852	Signaling by NOTCH3	0.03057364459617095	0.03057364459617095	+1	EGFR,NOTCH1,EP300
REAC:R-HSA-975138	TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation	0.03057364459617095	0.03057364459617095	+1	MAP3K1,MAP2K4,TLR4,PPP2R1A
REAC:R-HSA-201722	Formation of the beta-catenin:TCF transactivating complex	0.03143554369981849	0.03143554369981849	+1	CTNNB1,EP300,HIST1H2BD,AXIN2
REAC:R-HSA-168181	Toll Like Receptor 7/8 (TLR7/8) Cascade	0.03143554369981849	0.03143554369981849	+1	MAP3K1,MAP2K4,TLR4,PPP2R1A
REAC:R-HSA-975155	MyD88 dependent cascade initiated on endosome	0.03143554369981849	0.03143554369981849	+1	MAP3K1,MAP2K4,TLR4,PPP2R1A
REAC:R-HSA-9022699	MECP2 regulates neuronal receptors and channels	0.03215733997042315	0.03215733997042315	+1	NOTCH1,SIN3A
REAC:R-HSA-1839117	Signaling by cytosolic FGFR1 fusion mutants	0.03215733997042315	0.03215733997042315	+1	PIK3CA,PIK3R1
REAC:R-HSA-6804114	TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest	0.03215733997042315	0.03215733997042315	+1	TP53,EP300
REAC:R-HSA-1368082	RORA activates gene expression	0.03215733997042315	0.03215733997042315	+1	EP300,TBL1XR1
REAC:R-HSA-3214842	HDMs demethylate histones	0.03309376870555849	0.03309376870555849	+1	KDM6A,KDM5C,ARID5B
REAC:R-HSA-166058	MyD88:MAL(TIRAP) cascade initiated on plasma membrane	0.03309376870555849	0.03309376870555849	+1	MAP3K1,MAP2K4,TLR4,PPP2R1A
REAC:R-HSA-168188	Toll Like Receptor TLR6:TLR2 Cascade	0.03309376870555849	0.03309376870555849	+1	MAP3K1,MAP2K4,TLR4,PPP2R1A
REAC:R-HSA-8978934	Metabolism of cofactors	0.0351803130760961	0.0351803130760961	+1	IDH1,AKT1
REAC:R-HSA-5218921	VEGFR2 mediated cell proliferation	0.0351803130760961	0.0351803130760961	+1	KRAS,NRAS
REAC:R-HSA-168138	Toll Like Receptor 9 (TLR9) Cascade	0.03520287043663305	0.03520287043663305	+1	MAP3K1,MAP2K4,TLR4,PPP2R1A
REAC:R-HSA-168179	Toll Like Receptor TLR1:TLR2 Cascade	0.036123862468338847	0.036123862468338847	+1	MAP3K1,MAP2K4,TLR4,PPP2R1A
REAC:R-HSA-181438	Toll Like Receptor 2 (TLR2) Cascade	0.036123862468338847	0.036123862468338847	+1	MAP3K1,MAP2K4,TLR4,PPP2R1A
REAC:R-HSA-6781823	Formation of TC-NER Pre-Incision Complex	0.036123862468338847	0.036123862468338847	+1	CRIPAK,EP300,ERCC2
REAC:R-HSA-5693607	Processing of DNA double-strand break ends	0.03705565857737288	0.03705565857737288	+1	ATM,BRCA1,ATR,HIST1H2BD
REAC:R-HSA-937061	TRIF(TICAM1)-mediated TLR4 signaling 	0.03705565857737288	0.03705565857737288	+1	MAP2K4,TLR4,PPP2R1A,PTPN11
REAC:R-HSA-166166	MyD88-independent TLR4 cascade 	0.03705565857737288	0.03705565857737288	+1	MAP2K4,TLR4,PPP2R1A,PTPN11
REAC:R-HSA-3232118	SUMOylation of transcription factors	0.037393780283746604	0.037393780283746604	+1	TP53,CDKN2A
REAC:R-HSA-167044	Signalling to RAS	0.037393780283746604	0.037393780283746604	+1	KRAS,NRAS
REAC:R-HSA-8876384	Listeria monocytogenes entry into host cells	0.037393780283746604	0.037393780283746604	+1	CTNNB1,CDH1
REAC:R-HSA-6803204	TP53 Regulates Transcription of Genes Involved in Cytochrome C Release	0.037393780283746604	0.037393780283746604	+1	TP53,ATM
REAC:R-HSA-9013695	NOTCH4 Intracellular Domain Regulates Transcription	0.037393780283746604	0.037393780283746604	+1	NOTCH1,EP300
REAC:R-HSA-5654719	SHC-mediated cascade:FGFR4	0.037393780283746604	0.037393780283746604	+1	KRAS,NRAS
REAC:R-HSA-8941858	Regulation of RUNX3 expression and activity	0.03845368009410436	0.03845368009410436	+1	CDKN2A,EP300,CBFB
REAC:R-HSA-2151201	Transcriptional activation of mitochondrial biogenesis	0.03845368009410436	0.03845368009410436	+1	IDH2,TBL1XR1,NCOR1
REAC:R-HSA-3371556	Cellular response to heat stress	0.0386192684915625	0.0386192684915625	+1	ATM,MTOR,EP300,ATR
REAC:R-HSA-168898	Toll-like Receptor Cascades	0.03976345961409298	0.03976345961409298	+1	MAP3K1,MAP2K4,TLR4,PPP2R1A,PTPN11
REAC:R-HSA-6804115	TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain	0.040259740669123543	0.040259740669123543	+1	TP53,NPM1
REAC:R-HSA-5654688	SHC-mediated cascade:FGFR1	0.040259740669123543	0.040259740669123543	+1	KRAS,NRAS
REAC:R-HSA-210745	Regulation of gene expression in beta cells	0.040259740669123543	0.040259740669123543	+1	AKT1,FOXA2
REAC:R-HSA-6804754	Regulation of TP53 Expression	0.04343952659501396	0.04343952659501396	+1	TP53
REAC:R-HSA-912631	Regulation of signaling by CBL	0.04343952659501396	0.04343952659501396	+1	PIK3CA,PIK3R1
REAC:R-HSA-5638302	Signaling by Overexpressed Wild-Type EGFR in Cancer	0.04343952659501396	0.04343952659501396	+1	EGFR
REAC:R-HSA-3642279	TGFBR2 MSI Frameshift Mutants in Cancer	0.04343952659501396	0.04343952659501396	+1	TGFBR2
REAC:R-HSA-5638303	Inhibition of Signaling by Overexpressed EGFR	0.04343952659501396	0.04343952659501396	+1	EGFR
REAC:R-HSA-113510	E2F mediated regulation of DNA replication	0.04343952659501396	0.04343952659501396	+1	RB1,PPP2R1A
REAC:R-HSA-6802952	Signaling by BRAF and RAF fusions	0.04669414280242794	0.04669414280242794	+1	KRAS,NRAS,BRAF
REAC:R-HSA-187577	SCF(Skp2)-mediated degradation of p27/p21	0.04669414280242794	0.04669414280242794	+1	CDKN1B,CCND1,CDKN1A
REAC:R-HSA-373753	Nephrin family interactions	0.04670858884016126	0.04670858884016126	+1	PIK3CA,PIK3R1