GO.ID	Description	p.Val	FDR	Phenotype	Genes
GO:0048732	gland development	5.63111903714269e-13	5.63111903714269e-13	+1	NF1,GATA3,FBXW7,ARHGAP35,TBX3,CEBPA,AKT1,AR,SOX9,WT1,HGF,ERBB4,ARID5B,ELF3,FGFR2,BRCA2
GO:0046777	protein autophosphorylation	8.928649870055336e-12	8.928649870055336e-12	+1	EGFR,FLT3,STK11,AKT1,ATM,ERBB4,MTOR,LRRK2,CHEK2,KIT,PDGFRA,FGFR2,FGFR3,TAF1,ATR,CDK12,ACVR1B
GO:0048762	mesenchymal cell differentiation	9.884915455448333e-12	9.884915455448333e-12	+1	PTEN,NOTCH1,CTNNB1,EPHA3,SOX9,HGF,ERBB4,MTOR,FOXA1,FGFR2,SMAD4,FOXA2,TGFBR2,SMAD2,AXIN2,EZH2
GO:0060485	mesenchyme development	1.0352156654534308e-11	1.0352156654534308e-11	+1	PTEN,NOTCH1,CTNNB1,EPHA3,SOX9,WT1,HGF,ERBB4,MTOR,FOXA1,FGFR2,SMAD4,FOXA2,TGFBR2,SMAD2,AXIN2,EZH2
GO:0001837	epithelial to mesenchymal transition	1.1247384619781838e-11	1.1247384619781838e-11	+1	PTEN,NOTCH1,CTNNB1,EPHA3,SOX9,HGF,MTOR,FOXA1,SMAD4,FOXA2,TGFBR2,SMAD2,AXIN2,EZH2
GO:0010717	regulation of epithelial to mesenchymal transition	2.81463102687846e-11	2.81463102687846e-11	+1	PTEN,NOTCH1,CTNNB1,EPHA3,MTOR,FOXA1,SMAD4,FOXA2,TGFBR2,SMAD2,AXIN2,EZH2
GO:0007062	sister chromatid cohesion	8.785743920386444e-11	8.785743920386444e-11	+1	RB1,FBXW7,CTNNB1,CTCF,STAG2,ATRX,SMC1A,SMC3,AXIN2,RAD21
GO:0051348	negative regulation of transferase activity	2.858253822662523e-10	2.858253822662523e-10	+1	TP53,APC,NF1,CDKN2A,RB1,NPM1,CRIPAK,CEBPA,AKT1,CDKN1B,FOXA2,CDKN1A,PPP2R1A,EIF4A2,MAPK8IP1,RPL5
GO:0014065	phosphatidylinositol 3-kinase signaling	4.734567597224224e-10	4.734567597224224e-10	+1	PIK3CA,PTEN,EGFR,NF1,PIK3R1,GATA3,FLT3,AKT1,PIK3CG,SOX9,HGF,KIT,PDGFRA
GO:0048015	phosphatidylinositol-mediated signaling	2.56472460019257e-9	2.56472460019257e-9	+1	PIK3CA,PTEN,EGFR,NF1,PIK3R1,GATA3,FLT3,AKT1,PIK3CG,SOX9,HGF,KIT,PDGFRA
GO:0048017	inositol lipid-mediated signaling	2.779024437931432e-9	2.779024437931432e-9	+1	PIK3CA,PTEN,EGFR,NF1,PIK3R1,GATA3,FLT3,AKT1,PIK3CG,SOX9,HGF,KIT,PDGFRA
GO:0007050	cell cycle arrest	2.9615704196990605e-9	2.9615704196990605e-9	+1	TP53,APC,CDKN2A,RB1,NOTCH1,STK11,ATM,CDKN1B,MTOR,BRCA1,CHEK2,EP300,CCND1,CDKN1A,CDKN2C
GO:0034968	histone lysine methylation	3.1953973094590017e-9	3.1953973094590017e-9	+1	CTNNB1,KDM6A,TET2,ATRX,BRCA1,HIST1H1C,SETD2,SMAD4,NSD1,EZH2
GO:0009411	response to UV	3.1953973094590017e-9	3.1953973094590017e-9	+1	TP53,EGFR,NPM1,STK11,CRIPAK,AKT1,EP300,CCND1,CDKN1A,TAF1,ATR,ERCC2
GO:0045926	negative regulation of growth	3.4346564099389447e-9	3.4346564099389447e-9	+1	TP53,PTEN,CDKN2A,NOTCH1,STK11,CDKN1B,WT1,SMAD4,FGFR3,SOX17,CDKN1A,PPP2R1A,ACVR1B,CDKN2C
GO:0051896	regulation of protein kinase B signaling	1.8399561736260478e-8	1.8399561736260478e-8	+1	PIK3CA,PTEN,EGFR,PIK3R1,GATA3,AKT1,PIK3CG,HGF,ERBB4,KIT,PDGFRA,FGFR2,FGFR3,PTPN11
GO:0018022	peptidyl-lysine methylation	1.8610637991826444e-8	1.8610637991826444e-8	+1	CTNNB1,KDM6A,TET2,ATRX,BRCA1,HIST1H1C,SETD2,SMAD4,NSD1,EZH2
GO:0010718	positive regulation of epithelial to mesenchymal transition	2.840214131310384e-8	2.840214131310384e-8	+1	NOTCH1,CTNNB1,MTOR,SMAD4,TGFBR2,SMAD2,AXIN2,EZH2
GO:0016571	histone methylation	3.9385552591392834e-8	3.9385552591392834e-8	+1	CTNNB1,KDM6A,TET2,ATRX,BRCA1,HIST1H1C,SETD2,SMAD4,NSD1,EZH2
GO:0043491	protein kinase B signaling	4.243248910058965e-8	4.243248910058965e-8	+1	PIK3CA,PTEN,EGFR,PIK3R1,GATA3,AKT1,PIK3CG,HGF,ERBB4,KIT,PDGFRA,FGFR2,FGFR3,PTPN11
GO:0033673	negative regulation of kinase activity	5.763672801802703e-8	5.763672801802703e-8	+1	APC,NF1,CDKN2A,RB1,NPM1,CRIPAK,CEBPA,AKT1,CDKN1B,FOXA2,CDKN1A,PPP2R1A,MAPK8IP1
GO:0030518	intracellular steroid hormone receptor signaling pathway	6.289801020031679e-8	6.289801020031679e-8	+1	ARID1A,RB1,CTNNB1,RUNX1,CRIPAK,AR,BRCA1,FOXA1,EP300,CBFB,NCOR1
GO:0104004	cellular response to environmental stimulus	6.386978308575242e-8	6.386978308575242e-8	+1	TP53,PTEN,GATA3,MAP3K1,NPM1,MAP2K4,STK11,SOX9,ATM,TLR4,EP300,CDKN1A,TAF1,ATR
GO:0071214	cellular response to abiotic stimulus	6.386978308575242e-8	6.386978308575242e-8	+1	TP53,PTEN,GATA3,MAP3K1,NPM1,MAP2K4,STK11,SOX9,ATM,TLR4,EP300,CDKN1A,TAF1,ATR
GO:0051897	positive regulation of protein kinase B signaling	6.840273570813867e-8	6.840273570813867e-8	+1	PIK3CA,EGFR,PIK3R1,GATA3,PIK3CG,HGF,ERBB4,KIT,PDGFRA,FGFR2,FGFR3,PTPN11
GO:0072331	signal transduction by p53 class mediator	7.190994729372051e-8	7.190994729372051e-8	+1	TP53,STK11,AKT1,ATM,CDKN1B,ATRX,BRCA1,CHEK2,EP300,CDKN1A,TAF1,ATR,RPL5
GO:0043401	steroid hormone mediated signaling pathway	8.504803302368018e-8	8.504803302368018e-8	+1	ARID1A,RB1,CTNNB1,RUNX1,CRIPAK,AR,BRCA1,FOXA1,EP300,CBFB,NCOR1
GO:0030879	mammary gland development	8.728182668275193e-8	8.728182668275193e-8	+1	GATA3,ARHGAP35,TBX3,AKT1,ERBB4,ELF3,FGFR2,BRCA2
GO:1902806	regulation of cell cycle G1/S phase transition	9.377491086892238e-8	9.377491086892238e-8	+1	TP53,PTEN,RB1,FBXW7,ATM,CDKN1B,CHEK2,EP300,CCND1,CDKN1A,TAF1,EZH2
GO:0071824	protein-DNA complex subunit organization	9.393585630900472e-8	9.393585630900472e-8	+1	TP53,ARID1A,PBRM1,RB1,CTCF,NPM1,SOX9,ATRX,HIST1H1C,SETD2,TAF1,HIST1H2BD,H3F3C,ERCC2
GO:0050821	protein stabilization	9.888856176384178e-8	9.888856176384178e-8	+1	PTEN,VHL,PIK3R1,CDKN2A,FBXW7,CHEK2,EP300,USP9X,SOX17,CDKN1A,TAF1,RPL5
GO:0070372	regulation of ERK1 and ERK2 cascade	1.0862644544441269e-7	1.0862644544441269e-7	+1	PTEN,EGFR,NOTCH1,FBXW7,FLT3,BRAF,ERBB4,TLR4,KIT,PDGFRA,FGFR2,SMAD4,FGFR3,PTPN11
GO:0000819	sister chromatid segregation	1.276867727265892e-7	1.276867727265892e-7	+1	APC,RB1,FBXW7,CTNNB1,CTCF,STAG2,ATM,ATRX,SMC1A,SMC3,AXIN2,RAD21
GO:0007063	regulation of sister chromatid cohesion	1.5542329450623155e-7	1.5542329450623155e-7	+1	RB1,CTNNB1,CTCF,ATRX,AXIN2,RAD21
GO:0014066	regulation of phosphatidylinositol 3-kinase signaling	1.6686064972025456e-7	1.6686064972025456e-7	+1	PIK3CA,PTEN,EGFR,PIK3R1,FLT3,PIK3CG,SOX9,HGF,KIT,PDGFRA
GO:0030308	negative regulation of cell growth	2.0023668025567075e-7	2.0023668025567075e-7	+1	TP53,CDKN2A,STK11,CDKN1B,WT1,SMAD4,SOX17,CDKN1A,PPP2R1A,ACVR1B,CDKN2C
GO:0006469	negative regulation of protein kinase activity	2.0623274439160045e-7	2.0623274439160045e-7	+1	APC,NF1,CDKN2A,RB1,NPM1,CRIPAK,CEBPA,AKT1,CDKN1B,CDKN1A,PPP2R1A,MAPK8IP1
GO:0009416	response to light stimulus	2.1967358121296833e-7	2.1967358121296833e-7	+1	TP53,EGFR,NF1,NPM1,STK11,CRIPAK,AKT1,EP300,CCND1,CDKN1A,TAF1,ATR,ERCC2
GO:0006260	DNA replication	2.4421906228040553e-7	2.4421906228040553e-7	+1	EGFR,FBXW7,STAG2,ATM,ATRX,BRCA1,POLQ,CHEK2,BRCA2,PPP2R1A,ATR,SMC1A,SMC3
GO:0030522	intracellular receptor signaling pathway	2.9863758939671447e-7	2.9863758939671447e-7	+1	ARID1A,RB1,CTNNB1,RUNX1,CRIPAK,AR,BRCA1,FOXA1,EP300,ASXL1,CBFB,NCOR1,EZH2
GO:0090399	replicative senescence	3.016969728757146e-7	3.016969728757146e-7	+1	TP53,CDKN2A,ATM,CHEK2,ATR
GO:0006275	regulation of DNA replication	3.2828903510120453e-7	3.2828903510120453e-7	+1	EGFR,FBXW7,STAG2,ATRX,CHEK2,PPP2R1A,ATR,SMC1A,SMC3
GO:0048545	response to steroid hormone	3.464212554698898e-7	3.464212554698898e-7	+1	ARID1A,RB1,CTNNB1,RUNX1,IDH1,CRIPAK,AR,BRCA1,FOXA1,EP300,CBFB,NCOR1
GO:0008213	protein alkylation	5.080204233095212e-7	5.080204233095212e-7	+1	CTNNB1,KDM6A,TET2,ATRX,BRCA1,HIST1H1C,SETD2,SMAD4,NSD1,EZH2
GO:0006479	protein methylation	5.080204233095212e-7	5.080204233095212e-7	+1	CTNNB1,KDM6A,TET2,ATRX,BRCA1,HIST1H1C,SETD2,SMAD4,NSD1,EZH2
GO:0071383	cellular response to steroid hormone stimulus	5.705794551061592e-7	5.705794551061592e-7	+1	ARID1A,RB1,CTNNB1,RUNX1,CRIPAK,AR,BRCA1,FOXA1,EP300,CBFB,NCOR1
GO:0031647	regulation of protein stability	8.551130108858296e-7	8.551130108858296e-7	+1	PTEN,VHL,KRAS,PIK3R1,CDKN2A,FBXW7,CHEK2,EP300,USP9X,SOX17,CDKN1A,TAF1,RPL5
GO:0090068	positive regulation of cell cycle process	8.938822010071613e-7	8.938822010071613e-7	+1	TP53,RB1,NPM1,ATM,CDKN1B,ATRX,BRCA1,CHEK2,EP300,CCND1,CDKN1A,RAD21,EZH2
GO:0006333	chromatin assembly or disassembly	0.000001044713344926527	0.000001044713344926527	+1	TP53,ARID1A,PBRM1,CDKN2A,CTCF,NPM1,SOX9,ATRX,HIST1H1C,HIST1H2BD,H3F3C
GO:0030330	DNA damage response, signal transduction by p53 class mediator	0.0000011601497949849923	0.0000011601497949849923	+1	TP53,ATM,CDKN1B,ATRX,BRCA1,CHEK2,EP300,CDKN1A,ATR
GO:0033045	regulation of sister chromatid segregation	0.0000014756233778863858	0.0000014756233778863858	+1	APC,RB1,CTNNB1,CTCF,ATM,ATRX,AXIN2,RAD21
GO:0009755	hormone-mediated signaling pathway	0.0000014788239259433228	0.0000014788239259433228	+1	ARID1A,RB1,CTNNB1,RUNX1,CRIPAK,AR,BRCA1,FOXA1,EP300,CBFB,NCOR1
GO:0014068	positive regulation of phosphatidylinositol 3-kinase signaling	0.0000016248198516737088	0.0000016248198516737088	+1	PIK3CA,PIK3R1,FLT3,PIK3CG,SOX9,HGF,KIT,PDGFRA
GO:0032876	negative regulation of DNA endoreduplication	0.0000016484940173896019	0.0000016484940173896019	+1	FBXW7,STAG2,SMC1A,SMC3
GO:0034502	protein localization to chromosome	0.0000017806332681226903	0.0000017806332681226903	+1	RB1,CTCF,ATM,ATRX,SETD2,BRCA2,ATR,RAD21
GO:2000134	negative regulation of G1/S transition of mitotic cell cycle	0.0000018511194115386418	0.0000018511194115386418	+1	TP53,PTEN,RB1,ATM,CDKN1B,CHEK2,EP300,CCND1,CDKN1A
GO:0043414	macromolecule methylation	0.0000018793987385387371	0.0000018793987385387371	+1	CTNNB1,DNMT3A,KDM6A,WT1,TET2,ATRX,BRCA1,HIST1H1C,SETD2,SMAD4,NSD1,EZH2
GO:0007389	pattern specification process	0.0000018793987385387371	0.0000018793987385387371	+1	APC,NOTCH1,TBX3,WT1,ERBB4,FGFR2,FOXA2,TGFBR2,SOX17,ACVR1B,ACVR2A,SMAD2
GO:0000079	regulation of cyclin-dependent protein serine/threonine kinase activity	0.000001936253019816264	0.000001936253019816264	+1	PTEN,APC,CDKN2A,CEBPA,CDKN1B,CCND1,CDKN1A,CDKN2C
GO:0070374	positive regulation of ERK1 and ERK2 cascade	0.0000021082172893456177	0.0000021082172893456177	+1	EGFR,NOTCH1,FBXW7,FLT3,BRAF,ERBB4,KIT,PDGFRA,FGFR2,FGFR3,PTPN11
GO:0098813	nuclear chromosome segregation	0.0000021444041115810607	0.0000021444041115810607	+1	APC,RB1,FBXW7,CTNNB1,CTCF,STAG2,ATM,ATRX,SMC1A,SMC3,AXIN2,RAD21
GO:0048863	stem cell differentiation	0.0000022264166913361116	0.0000022264166913361116	+1	GATA3,NOTCH1,RUNX1,SOX9,ERBB4,KIT,SETD2,PDGFRA,FGFR2,CBFB
GO:0007548	sex differentiation	0.000002645688728714964	0.000002645688728714964	+1	GATA3,TBX3,AR,SOX9,WT1,KIT,PDGFRA,BRCA2,PTPN11
GO:1902807	negative regulation of cell cycle G1/S phase transition	0.000002645688728714964	0.000002645688728714964	+1	TP53,PTEN,RB1,ATM,CDKN1B,CHEK2,EP300,CCND1,CDKN1A
GO:0044786	cell cycle DNA replication	0.0000027978538243605838	0.0000027978538243605838	+1	FBXW7,STAG2,ATRX,CHEK2,BRCA2,SMC1A,SMC3
GO:0048608	reproductive structure development	0.000002997343738080094	0.000002997343738080094	+1	GATA3,TBX3,AR,SOX9,WT1,KIT,PDGFRA,FGFR2,BRCA2,PTPN11
GO:0061458	reproductive system development	0.000002997343738080094	0.000002997343738080094	+1	GATA3,TBX3,AR,SOX9,WT1,KIT,PDGFRA,FGFR2,BRCA2,PTPN11
GO:0007569	cell aging	0.000003010821471944302	0.000003010821471944302	+1	TP53,CDKN2A,NPM1,TBX3,ATM,CHEK2,CDKN1A,ATR
GO:1904029	regulation of cyclin-dependent protein kinase activity	0.000003010821471944302	0.000003010821471944302	+1	PTEN,APC,CDKN2A,CEBPA,CDKN1B,CCND1,CDKN1A,CDKN2C
GO:0000082	G1/S transition of mitotic cell cycle	0.0000031566009853148088	0.0000031566009853148088	+1	TP53,PTEN,CDKN2A,RB1,ATM,CDKN1B,CHEK2,EP300,CCND1,CDKN1A,ACVR1B,CDKN2C
GO:0032259	methylation	0.0000032871455918372706	0.0000032871455918372706	+1	CTNNB1,DNMT3A,KDM6A,WT1,TET2,ATRX,BRCA1,HIST1H1C,SETD2,SMAD4,NSD1,EZH2
GO:0008156	negative regulation of DNA replication	0.0000033327924609113044	0.0000033327924609113044	+1	FBXW7,STAG2,CHEK2,ATR,SMC1A,SMC3
GO:0007568	aging	0.0000034582012521791454	0.0000034582012521791454	+1	TP53,CDKN2A,NPM1,TBX3,ATM,LRRK2,CHEK2,CDKN1A,ATR
GO:0018108	peptidyl-tyrosine phosphorylation	0.000003915595078720115	0.000003915595078720115	+1	TP53,EGFR,FBXW7,FLT3,EPHA3,HGF,ERBB4,KIT,PDGFRA,FGFR2,FGFR3,PPP2R1A
GO:1901796	regulation of signal transduction by p53 class mediator	0.000003985000606024368	0.000003985000606024368	+1	TP53,STK11,AKT1,ATM,CHEK2,EP300,TAF1,ATR,RPL5
GO:0060070	canonical Wnt signaling pathway	0.000004431216486315411	0.000004431216486315411	+1	PTEN,APC,EGFR,GATA3,CTNNB1,STK11,SOX9,LRRK2,FGFR2,SOX17,TBL1XR1,AXIN2
GO:0018212	peptidyl-tyrosine modification	0.000004431216486315411	0.000004431216486315411	+1	TP53,EGFR,FBXW7,FLT3,EPHA3,HGF,ERBB4,KIT,PDGFRA,FGFR2,FGFR3,PPP2R1A
GO:1901988	negative regulation of cell cycle phase transition	0.000004846808718357132	0.000004846808718357132	+1	TP53,PTEN,APC,RB1,ATM,CDKN1B,BRCA1,CHEK2,EP300,CCND1,CDKN1A
GO:0032875	regulation of DNA endoreduplication	0.000005197975996393909	0.000005197975996393909	+1	FBXW7,STAG2,SMC1A,SMC3
GO:0000075	cell cycle checkpoint	0.000005554892037444751	0.000005554892037444751	+1	TP53,APC,RB1,ATM,CDKN1B,BRCA1,CHEK2,EP300,CCND1,CDKN1A,ATR
GO:0034728	nucleosome organization	0.000005554892037444751	0.000005554892037444751	+1	ARID1A,PBRM1,CTCF,NPM1,SOX9,ATRX,HIST1H1C,SETD2,HIST1H2BD,H3F3C
GO:2000058	regulation of ubiquitin-dependent protein catabolic process	0.000005554892037444751	0.000005554892037444751	+1	PTEN,CDKN2A,FBXW7,KEAP1,NFE2L2,CEBPA,LRRK2,TAF1,RPL5
GO:0001655	urogenital system development	0.000005831696286079401	0.000005831696286079401	+1	NF1,GATA3,CTNNB1,AR,SOX9,WT1,LRRK2,PDGFRA,FGFR2,SOX17
GO:1904030	negative regulation of cyclin-dependent protein kinase activity	0.000005831696286079401	0.000005831696286079401	+1	APC,CDKN2A,CEBPA,CDKN1B,CDKN1A
GO:0031571	mitotic G1 DNA damage checkpoint	0.000006018516309020677	0.000006018516309020677	+1	TP53,ATM,CDKN1B,CHEK2,EP300,CCND1,CDKN1A
GO:0044819	mitotic G1/S transition checkpoint	0.000006018516309020677	0.000006018516309020677	+1	TP53,ATM,CDKN1B,CHEK2,EP300,CCND1,CDKN1A
GO:0051054	positive regulation of DNA metabolic process	0.000006106983977617863	0.000006106983977617863	+1	EGFR,AKT1,ATM,WT1,HGF,ATRX,BRCA1,USP9X,ATR,ERCC2
GO:0042770	signal transduction in response to DNA damage	0.0000066325879828033155	0.0000066325879828033155	+1	TP53,ATM,CDKN1B,ATRX,BRCA1,CHEK2,EP300,CDKN1A,ATR
GO:2000027	regulation of animal organ morphogenesis	0.0000066325879828033155	0.0000066325879828033155	+1	GATA3,NOTCH1,FBXW7,CTNNB1,SOX9,WT1,HGF,FGFR2,TGFBR2
GO:0044783	G1 DNA damage checkpoint	0.0000066325879828033155	0.0000066325879828033155	+1	TP53,ATM,CDKN1B,CHEK2,EP300,CCND1,CDKN1A
GO:0030521	androgen receptor signaling pathway	0.000008079722866294361	0.000008079722866294361	+1	ARID1A,RB1,CTNNB1,AR,BRCA1,EP300,NCOR1
GO:0002244	hematopoietic progenitor cell differentiation	0.000008079722866294361	0.000008079722866294361	+1	GATA3,NOTCH1,FLT3,RUNX1,KIT,PDGFRA,CBFB
GO:0033143	regulation of intracellular steroid hormone receptor signaling pathway	0.000008079722866294361	0.000008079722866294361	+1	RUNX1,CRIPAK,BRCA1,FOXA1,EP300,CBFB,NCOR1
GO:0051568	histone H3-K4 methylation	0.000008107128599642884	0.000008107128599642884	+1	CTNNB1,KDM6A,TET2,BRCA1,HIST1H1C,SMAD4
GO:2000677	regulation of transcription regulatory region DNA binding	0.000008107128599642884	0.000008107128599642884	+1	GATA3,RB1,CTNNB1,TAF1,SIN3A,NSD1
GO:0042023	DNA endoreduplication	0.000008107128599642884	0.000008107128599642884	+1	FBXW7,STAG2,SMC1A,SMC3
GO:0051983	regulation of chromosome segregation	0.000009194222281175329	0.000009194222281175329	+1	APC,RB1,CTNNB1,CTCF,ATM,ATRX,AXIN2,RAD21
GO:0071496	cellular response to external stimulus	0.000010080159270238853	0.000010080159270238853	+1	TP53,MAP3K1,ARHGAP35,MAP2K4,SOX9,MTOR,TLR4,LRRK2,FOXA2,CDKN1A,TAF1
GO:2000104	negative regulation of DNA-dependent DNA replication	0.0000110850461252042	0.0000110850461252042	+1	FBXW7,STAG2,CHEK2,SMC1A,SMC3
GO:0034644	cellular response to UV	0.00001174836228440958	0.00001174836228440958	+1	TP53,NPM1,STK11,EP300,CDKN1A,TAF1,ATR
GO:0000077	DNA damage checkpoint	0.000011889013901292417	0.000011889013901292417	+1	TP53,ATM,CDKN1B,BRCA1,CHEK2,EP300,CCND1,CDKN1A,ATR
GO:0006352	DNA-templated transcription, initiation	0.000011889013901292417	0.000011889013901292417	+1	TP53,PTEN,NOTCH1,CTNNB1,AR,SOX9,CCND1,CDKN1A,TAF1,CBFB,ERCC2
GO:0001763	morphogenesis of a branching structure	0.000012833393109936034	0.000012833393109936034	+1	CTNNB1,SOX9,WT1,HGF,LRRK2,FGFR2,TGFBR2
GO:1901991	negative regulation of mitotic cell cycle phase transition	0.00001466879238943023	0.00001466879238943023	+1	TP53,PTEN,APC,RB1,ATM,CDKN1B,CHEK2,EP300,CCND1,CDKN1A
GO:0006367	transcription initiation from RNA polymerase II promoter	0.00001466879238943023	0.00001466879238943023	+1	TP53,PTEN,NOTCH1,AR,SOX9,CCND1,CDKN1A,TAF1,CBFB,ERCC2
GO:2001252	positive regulation of chromosome organization	0.000015749203177114552	0.000015749203177114552	+1	RB1,CTNNB1,ATM,ATRX,BRCA1,SMAD4,ATR,SIN3A,RAD21
GO:0006338	chromatin remodeling	0.000015749203177114552	0.000015749203177114552	+1	ARID1A,PBRM1,CDKN2A,RB1,NPM1,KDM6A,SOX9,ATRX,FOXA1
GO:0071156	regulation of cell cycle arrest	0.00001595345268472964	0.00001595345268472964	+1	TP53,ATM,CDKN1B,BRCA1,CHEK2,EP300,CCND1,CDKN1A
GO:0097193	intrinsic apoptotic signaling pathway	0.000016428536475300943	0.000016428536475300943	+1	TP53,FBXW7,NFE2L2,STK11,AKT1,ATM,BRCA1,LRRK2,CHEK2,EP300,CDKN1A
GO:0072422	signal transduction involved in DNA damage checkpoint	0.00001658531314539824	0.00001658531314539824	+1	TP53,ATM,CDKN1B,BRCA1,CHEK2,EP300,CDKN1A
GO:0072401	signal transduction involved in DNA integrity checkpoint	0.00001658531314539824	0.00001658531314539824	+1	TP53,ATM,CDKN1B,BRCA1,CHEK2,EP300,CDKN1A
GO:0090329	regulation of DNA-dependent DNA replication	0.000017307051274293048	0.000017307051274293048	+1	FBXW7,STAG2,ATRX,CHEK2,SMC1A,SMC3
GO:0072395	signal transduction involved in cell cycle checkpoint	0.000018108125009159566	0.000018108125009159566	+1	TP53,ATM,CDKN1B,BRCA1,CHEK2,EP300,CDKN1A
GO:0031497	chromatin assembly	0.000018416794372522058	0.000018416794372522058	+1	TP53,CDKN2A,CTCF,NPM1,SOX9,ATRX,HIST1H1C,HIST1H2BD,H3F3C
GO:0070602	regulation of centromeric sister chromatid cohesion	0.00001910380955813492	0.00001910380955813492	+1	CTNNB1,CTCF,AXIN2
GO:0051091	positive regulation of DNA-binding transcription factor activity	0.00001910380955813492	0.00001910380955813492	+1	PTEN,CTNNB1,NPM1,AKT1,AR,TLR4,ARID5B,FOXA1,KIT,EP300,TAF1
GO:0061180	mammary gland epithelium development	0.000019320495000951203	0.000019320495000951203	+1	GATA3,AKT1,ERBB4,FGFR2,BRCA2
GO:0043550	regulation of lipid kinase activity	0.000019320495000951203	0.000019320495000951203	+1	PIK3R1,RB1,FLT3,KIT,PDGFRA,FGFR3
GO:2000045	regulation of G1/S transition of mitotic cell cycle	0.000020415505317919453	0.000020415505317919453	+1	TP53,PTEN,RB1,ATM,CDKN1B,CHEK2,EP300,CCND1,CDKN1A
GO:0071901	negative regulation of protein serine/threonine kinase activity	0.00002050673320347277	0.00002050673320347277	+1	APC,NF1,CDKN2A,CEBPA,AKT1,CDKN1B,PPP2R1A,MAPK8IP1
GO:0031570	DNA integrity checkpoint	0.000022705515246885173	0.000022705515246885173	+1	TP53,ATM,CDKN1B,BRCA1,CHEK2,EP300,CCND1,CDKN1A,ATR
GO:0022612	gland morphogenesis	0.000023028789209828627	0.000023028789209828627	+1	FBXW7,SOX9,HGF,ELF3,FGFR2
GO:0072001	renal system development	0.000023783096787639043	0.000023783096787639043	+1	NF1,GATA3,CTNNB1,SOX9,WT1,LRRK2,PDGFRA,FGFR2,SOX17
GO:0030520	intracellular estrogen receptor signaling pathway	0.00002414565994506563	0.00002414565994506563	+1	ARID1A,RUNX1,CRIPAK,BRCA1,FOXA1,CBFB
GO:2000060	positive regulation of ubiquitin-dependent protein catabolic process	0.000024836329794285184	0.000024836329794285184	+1	PTEN,FBXW7,KEAP1,NFE2L2,CEBPA,LRRK2,TAF1
GO:0071158	positive regulation of cell cycle arrest	0.000024836329794285184	0.000024836329794285184	+1	TP53,ATM,CDKN1B,BRCA1,CHEK2,EP300,CDKN1A
GO:0110110	positive regulation of animal organ morphogenesis	0.00002692818565891312	0.00002692818565891312	+1	GATA3,NOTCH1,SOX9,WT1,FGFR2,TGFBR2
GO:0043276	anoikis	0.000027053586959978173	0.000027053586959978173	+1	PIK3CA,NOTCH1,STK11,AKT1,MTOR
GO:0009880	embryonic pattern specification	0.000027053586959978173	0.000027053586959978173	+1	TBX3,WT1,ERBB4,FGFR2,SMAD2
GO:0071478	cellular response to radiation	0.00003048003609896525	0.00003048003609896525	+1	TP53,GATA3,NPM1,STK11,ATM,EP300,CDKN1A,TAF1,ATR
GO:0022409	positive regulation of cell-cell adhesion	0.000031843979335470656	0.000031843979335470656	+1	PIK3CA,PIK3R1,GATA3,RUNX1,AKT1,FOXA1,FOXA2,TGFBR2,CBFB,PTPN11
GO:0044839	cell cycle G2/M phase transition	0.00003627713807145098	0.00003627713807145098	+1	TP53,CDKN2A,NPM1,AJUBA,ATM,BRCA1,CHEK2,CCND1,CDKN1A,PPP2R1A
GO:0061041	regulation of wound healing	0.00003786967343041758	0.00003786967343041758	+1	PTEN,EPPK1,CDKN1B,MTOR,TLR4,PDGFRA,FOXA2,CDKN1A
GO:0007093	mitotic cell cycle checkpoint	0.00003905839277669615	0.00003905839277669615	+1	TP53,APC,RB1,ATM,CDKN1B,CHEK2,EP300,CCND1,CDKN1A
GO:0090100	positive regulation of transmembrane receptor protein serine/threonine kinase signaling pathway	0.00003943187012052443	0.00003943187012052443	+1	NOTCH1,STK11,EP300,SMAD4,ACVR1B,ACVR2A,SMAD2
GO:2000736	regulation of stem cell differentiation	0.00004077620445995737	0.00004077620445995737	+1	GATA3,NOTCH1,RUNX1,SOX9,PDGFRA,CBFB
GO:0070507	regulation of microtubule cytoskeleton organization	0.00004084530018132182	0.00004084530018132182	+1	APC,NAV3,CTNNB1,NPM1,EPHA3,STAG2,BRCA1,SMC1A,SMC3
GO:0060828	regulation of canonical Wnt signaling pathway	0.000042574287784489506	0.000042574287784489506	+1	APC,EGFR,CTNNB1,STK11,SOX9,LRRK2,FGFR2,SOX17,TBL1XR1,AXIN2
GO:0048511	rhythmic process	0.000042700040117495956	0.000042700040117495956	+1	TP53,PTEN,PDGFRA,EP300,USP9X,SIN3A,EGR3,NCOR1,EZH2
GO:0033146	regulation of intracellular estrogen receptor signaling pathway	0.00004315291845808512	0.00004315291845808512	+1	RUNX1,CRIPAK,BRCA1,FOXA1,CBFB
GO:0071680	response to indole-3-methanol	0.000043388861589560336	0.000043388861589560336	+1	CTNNB1,CDH1,BRCA1
GO:0071681	cellular response to indole-3-methanol	0.000043388861589560336	0.000043388861589560336	+1	CTNNB1,CDH1,BRCA1
GO:0006977	DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest	0.00004434378618461596	0.00004434378618461596	+1	TP53,ATM,CDKN1B,CHEK2,EP300,CDKN1A
GO:0003151	outflow tract morphogenesis	0.00004434378618461596	0.00004434378618461596	+1	NOTCH1,CTNNB1,FGFR2,SMAD4,TGFBR2,SOX17
GO:1903201	regulation of oxidative stress-induced cell death	0.000048690739303544886	0.000048690739303544886	+1	FBXW7,NFE2L2,AKT1,HGF,TLR4,LRRK2
GO:0072431	signal transduction involved in mitotic G1 DNA damage checkpoint	0.000048690739303544886	0.000048690739303544886	+1	TP53,ATM,CDKN1B,CHEK2,EP300,CDKN1A
GO:1902400	intracellular signal transduction involved in G1 DNA damage checkpoint	0.000048690739303544886	0.000048690739303544886	+1	TP53,ATM,CDKN1B,CHEK2,EP300,CDKN1A
GO:0072413	signal transduction involved in mitotic cell cycle checkpoint	0.000058634353095623705	0.000058634353095623705	+1	TP53,ATM,CDKN1B,CHEK2,EP300,CDKN1A
GO:1902402	signal transduction involved in mitotic DNA damage checkpoint	0.000058634353095623705	0.000058634353095623705	+1	TP53,ATM,CDKN1B,CHEK2,EP300,CDKN1A
GO:1902403	signal transduction involved in mitotic DNA integrity checkpoint	0.000058634353095623705	0.000058634353095623705	+1	TP53,ATM,CDKN1B,CHEK2,EP300,CDKN1A
GO:0010212	response to ionizing radiation	0.0000633550906920012	0.0000633550906920012	+1	TP53,GATA3,STK11,ATM,BRCA1,CDKN1A,ATR
GO:0006261	DNA-dependent DNA replication	0.00006832930008578222	0.00006832930008578222	+1	FBXW7,STAG2,ATRX,POLQ,CHEK2,BRCA2,SMC1A,SMC3
GO:1903050	regulation of proteolysis involved in cellular protein catabolic process	0.00007460084322041007	0.00007460084322041007	+1	PTEN,CDKN2A,FBXW7,KEAP1,NFE2L2,CEBPA,LRRK2,TAF1,RPL5
GO:0038127	ERBB signaling pathway	0.00007474732757477786	0.00007474732757477786	+1	PIK3CA,EGFR,PIK3R1,FBXW7,AKT1,SOX9,ERBB4,PTPN11
GO:0061138	morphogenesis of a branching epithelium	0.00007547491785716313	0.00007547491785716313	+1	CTNNB1,SOX9,WT1,HGF,FGFR2,TGFBR2
GO:0035690	cellular response to drug	0.00007591005074610347	0.00007591005074610347	+1	TP53,CTNNB1,CDH1,NFE2L2,SOX9,HGF,ATRX,BRCA1,LRRK2,TAF1
GO:0044773	mitotic DNA damage checkpoint	0.00007591005074610347	0.00007591005074610347	+1	TP53,ATM,CDKN1B,CHEK2,EP300,CCND1,CDKN1A
GO:0048638	regulation of developmental growth	0.00007733113479299112	0.00007733113479299112	+1	PTEN,NOTCH1,EPPK1,CDKN1B,WT1,ERBB4,FGFR2,FGFR3,CDKN1A
GO:1903034	regulation of response to wounding	0.00007821987360126147	0.00007821987360126147	+1	PTEN,EPPK1,CDKN1B,MTOR,TLR4,PDGFRA,FOXA2,CDKN1A
GO:0070141	response to UV-A	0.00007901641431764064	0.00007901641431764064	+1	EGFR,AKT1,CCND1
GO:0032927	positive regulation of activin receptor signaling pathway	0.00007901641431764064	0.00007901641431764064	+1	ACVR1B,ACVR2A,SMAD2
GO:0003281	ventricular septum development	0.00008236132255754905	0.00008236132255754905	+1	GATA3,NOTCH1,FGFR2,SMAD4,TGFBR2
GO:0045736	negative regulation of cyclin-dependent protein serine/threonine kinase activity	0.0000857128311439456	0.0000857128311439456	+1	APC,CDKN2A,CEBPA,CDKN1B
GO:1903052	positive regulation of proteolysis involved in cellular protein catabolic process	0.00008580741638638578	0.00008580741638638578	+1	PTEN,FBXW7,KEAP1,NFE2L2,CEBPA,LRRK2,TAF1
GO:0071103	DNA conformation change	0.00008728850343912368	0.00008728850343912368	+1	TP53,CDKN2A,CTCF,NPM1,SOX9,ATRX,HIST1H1C,HIST1H2BD,H3F3C,ERCC2
GO:0001666	response to hypoxia	0.00008728850343912368	0.00008728850343912368	+1	TP53,VHL,NF1,NOTCH1,NFE2L2,AJUBA,MTOR,EP300,SMAD4
GO:1900407	regulation of cellular response to oxidative stress	0.00008861930119715905	0.00008861930119715905	+1	FBXW7,NFE2L2,AKT1,HGF,TLR4,LRRK2
GO:0006323	DNA packaging	0.00009930641202541867	0.00009930641202541867	+1	TP53,CDKN2A,CTCF,NPM1,SOX9,ATRX,HIST1H1C,HIST1H2BD,H3F3C
GO:0036293	response to decreased oxygen levels	0.00009930641202541867	0.00009930641202541867	+1	TP53,VHL,NF1,NOTCH1,NFE2L2,AJUBA,MTOR,EP300,SMAD4
GO:0001822	kidney development	0.00010044368173092327	0.00010044368173092327	+1	NF1,GATA3,CTNNB1,SOX9,WT1,LRRK2,PDGFRA,FGFR2
GO:1903725	regulation of phospholipid metabolic process	0.00010494756667079507	0.00010494756667079507	+1	PIK3R1,FLT3,IDH1,KIT,PDGFRA,FGFR3
GO:0045732	positive regulation of protein catabolic process	0.00011199683066419427	0.00011199683066419427	+1	PTEN,APC,FBXW7,KEAP1,NFE2L2,CEBPA,CDKN1B,LRRK2,TAF1
GO:0050863	regulation of T cell activation	0.00011576173295936335	0.00011576173295936335	+1	PIK3CA,PIK3R1,CDKN2A,GATA3,RUNX1,AKT1,TGFBR2,CBFB,PTPN11,MAPK8IP1
GO:0043551	regulation of phosphatidylinositol 3-kinase activity	0.00011781717158588576	0.00011781717158588576	+1	PIK3R1,FLT3,KIT,PDGFRA,FGFR3
GO:0031060	regulation of histone methylation	0.00011781717158588576	0.00011781717158588576	+1	CTNNB1,ATRX,BRCA1,SMAD4,NSD1
GO:0045165	cell fate commitment	0.00012120059549611492	0.00012120059549611492	+1	APC,GATA3,SOX9,WT1,FGFR2,FOXA2,SOX17,SMAD2
GO:0032886	regulation of microtubule-based process	0.00012575490505159278	0.00012575490505159278	+1	APC,NAV3,CTNNB1,NPM1,EPHA3,STAG2,BRCA1,SMC1A,SMC3
GO:0007623	circadian rhythm	0.00012683809688813702	0.00012683809688813702	+1	TP53,PTEN,EP300,USP9X,SIN3A,EGR3,NCOR1,EZH2
GO:0044774	mitotic DNA integrity checkpoint	0.00013061505015227358	0.00013061505015227358	+1	TP53,ATM,CDKN1B,CHEK2,EP300,CCND1,CDKN1A
GO:0061026	cardiac muscle tissue regeneration	0.00013061505015227358	0.00013061505015227358	+1	CDKN1B,ERBB4,CDKN1A
GO:0009895	negative regulation of catabolic process	0.0001364743438851525	0.0001364743438851525	+1	PIK3CA,EGFR,CDKN2A,AKT1,HGF,MTOR,LRRK2,TAF1,RPL5,AXIN2
GO:0035265	organ growth	0.00013831953962575988	0.00013831953962575988	+1	PTEN,NOTCH1,SOX9,WT1,ERBB4,FGFR2,FGFR3
GO:1903320	regulation of protein modification by small protein conjugation or removal	0.000140689861022264	0.000140689861022264	+1	PTEN,CDKN2A,FBXW7,CTNNB1,AKT1,BRCA1,LRRK2,TAF1,RPL5
GO:0018105	peptidyl-serine phosphorylation	0.000140689861022264	0.000140689861022264	+1	EGFR,AKT1,BRAF,ATM,MTOR,LRRK2,TGFBR2,TAF1,ATR,NSD1
GO:1902882	regulation of response to oxidative stress	0.0001418117849026369	0.0001418117849026369	+1	FBXW7,NFE2L2,AKT1,HGF,TLR4,LRRK2
GO:0019827	stem cell population maintenance	0.0001418117849026369	0.0001418117849026369	+1	NOTCH1,CTNNB1,SOX9,KIT,SMAD4,SMAD2
GO:0043409	negative regulation of MAPK cascade	0.00014504465630855353	0.00014504465630855353	+1	PTEN,NF1,TLR4,SMAD4,PPP2R1A,MAPK8IP1,MECOM,NCOR1
GO:0045637	regulation of myeloid cell differentiation	0.00014519951946027798	0.00014519951946027798	+1	FBXW7,RUNX1,MTOR,TLR4,EP300,CBFB,SIN3A,ACVR1B,ACVR2A
GO:0050730	regulation of peptidyl-tyrosine phosphorylation	0.00014519951946027798	0.00014519951946027798	+1	TP53,EGFR,FBXW7,FLT3,HGF,ERBB4,KIT,FGFR3,PPP2R1A
GO:0046660	female sex differentiation	0.0001454123793086732	0.0001454123793086732	+1	TBX3,WT1,KIT,PDGFRA,BRCA2
GO:0070482	response to oxygen levels	0.00015079800965048422	0.00015079800965048422	+1	TP53,VHL,NF1,NOTCH1,NFE2L2,AJUBA,MTOR,EP300,SMAD4
GO:0043618	regulation of transcription from RNA polymerase II promoter in response to stress	0.0001518212066608859	0.0001518212066608859	+1	TP53,VHL,NOTCH1,NFE2L2,EP300,TAF1
GO:0098727	maintenance of cell number	0.0001518212066608859	0.0001518212066608859	+1	NOTCH1,CTNNB1,SOX9,KIT,SMAD4,SMAD2
GO:1901522	positive regulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus	0.00015278164251557007	0.00015278164251557007	+1	NOTCH1,NFE2L2,EP300,SMAD4
GO:0072089	stem cell proliferation	0.00016298619716507886	0.00016298619716507886	+1	NF1,CTNNB1,RUNX1,LRRK2,FGFR2,MECOM
GO:0036473	cell death in response to oxidative stress	0.00016298619716507886	0.00016298619716507886	+1	FBXW7,NFE2L2,AKT1,HGF,TLR4,LRRK2
GO:0065004	protein-DNA complex assembly	0.00016770573212784973	0.00016770573212784973	+1	TP53,RB1,NPM1,SOX9,ATRX,TAF1,HIST1H2BD,H3F3C,ERCC2
GO:1902115	regulation of organelle assembly	0.00017157776704511787	0.00017157776704511787	+1	ARHGAP35,NPM1,STAG2,BRCA1,LRRK2,SMAD4,SMC1A,SMC3
GO:0003179	heart valve morphogenesis	0.00017878512500413637	0.00017878512500413637	+1	GATA3,RB1,NOTCH1,SOX9,TGFBR2
GO:0007173	epidermal growth factor receptor signaling pathway	0.00017998834683141202	0.00017998834683141202	+1	PIK3CA,EGFR,PIK3R1,FBXW7,AKT1,SOX9,PTPN11
GO:0071560	cellular response to transforming growth factor beta stimulus	0.00018016558307175514	0.00018016558307175514	+1	STK11,SOX9,EP300,SMAD4,USP9X,TGFBR2,ACVR1B,ACVR2A,SMAD2
GO:0006359	regulation of transcription by RNA polymerase III	0.00018068721121843243	0.00018068721121843243	+1	CEBPA,AR,MTOR,BRCA1
GO:0016242	negative regulation of macroautophagy	0.00018068721121843243	0.00018068721121843243	+1	PIK3CA,AKT1,MTOR,LRRK2
GO:0071482	cellular response to light stimulus	0.0001888270401821486	0.0001888270401821486	+1	TP53,NPM1,STK11,EP300,CDKN1A,TAF1,ATR
GO:0060562	epithelial tube morphogenesis	0.00019476979414606013	0.00019476979414606013	+1	GATA3,NOTCH1,CTNNB1,SOX9,WT1,FGFR2,TGFBR2,SOX17
GO:0033002	muscle cell proliferation	0.000203804943023135	0.000203804943023135	+1	PTEN,NOTCH1,CTNNB1,AKT1,CDKN1B,ERBB4,FGFR2,CDKN1A
GO:1903362	regulation of cellular protein catabolic process	0.00021529286580393594	0.00021529286580393594	+1	PTEN,CDKN2A,FBXW7,KEAP1,NFE2L2,CEBPA,LRRK2,TAF1,RPL5
GO:0031330	negative regulation of cellular catabolic process	0.00021529286580393594	0.00021529286580393594	+1	PIK3CA,CDKN2A,AKT1,HGF,MTOR,LRRK2,TAF1,RPL5,AXIN2
GO:0003170	heart valve development	0.000216654317949485	0.000216654317949485	+1	GATA3,RB1,NOTCH1,SOX9,TGFBR2
GO:0001656	metanephros development	0.000216654317949485	0.000216654317949485	+1	NF1,GATA3,SOX9,WT1,PDGFRA
GO:0050870	positive regulation of T cell activation	0.00022084813268552665	0.00022084813268552665	+1	PIK3CA,PIK3R1,GATA3,RUNX1,AKT1,TGFBR2,CBFB,PTPN11
GO:0043620	regulation of DNA-templated transcription in response to stress	0.00022984373523334106	0.00022984373523334106	+1	TP53,VHL,NOTCH1,NFE2L2,EP300,TAF1
GO:0071559	response to transforming growth factor beta	0.00023058458145767917	0.00023058458145767917	+1	STK11,SOX9,EP300,SMAD4,USP9X,TGFBR2,ACVR1B,ACVR2A,SMAD2
GO:0071456	cellular response to hypoxia	0.00023184117489919915	0.00023184117489919915	+1	TP53,VHL,NOTCH1,NFE2L2,AJUBA,MTOR,EP300
GO:0046425	regulation of receptor signaling pathway via JAK-STAT	0.00023184117489919915	0.00023184117489919915	+1	VHL,NOTCH1,FLT3,ERBB4,KIT,FGFR3,PPP2R1A
GO:1903364	positive regulation of cellular protein catabolic process	0.00023184117489919915	0.00023184117489919915	+1	PTEN,FBXW7,KEAP1,NFE2L2,CEBPA,LRRK2,TAF1
GO:0008593	regulation of Notch signaling pathway	0.0002438101109781941	0.0002438101109781941	+1	EGFR,NOTCH1,FBXW7,AKT1,ELF3,EP300
GO:0060688	regulation of morphogenesis of a branching structure	0.0002484966801772256	0.0002484966801772256	+1	SOX9,HGF,LRRK2,FGFR2
GO:0036294	cellular response to decreased oxygen levels	0.0002696453632683818	0.0002696453632683818	+1	TP53,VHL,NOTCH1,NFE2L2,AJUBA,MTOR,EP300
GO:0045945	positive regulation of transcription by RNA polymerase III	0.00027869595880770036	0.00027869595880770036	+1	CEBPA,AR,MTOR
GO:1904892	regulation of receptor signaling pathway via STAT	0.0002827692797040043	0.0002827692797040043	+1	VHL,NOTCH1,FLT3,ERBB4,KIT,FGFR3,PPP2R1A
GO:0003180	aortic valve morphogenesis	0.0002903602826101214	0.0002903602826101214	+1	GATA3,RB1,NOTCH1,SOX9
GO:0034599	cellular response to oxidative stress	0.00029105417048127163	0.00029105417048127163	+1	TP53,EGFR,FBXW7,NFE2L2,AKT1,HGF,TLR4,LRRK2,PDGFRA
GO:0071479	cellular response to ionizing radiation	0.00031325178378641724	0.00031325178378641724	+1	TP53,GATA3,ATM,CDKN1A,ATR
GO:0008406	gonad development	0.0003154190149991054	0.0003154190149991054	+1	GATA3,SOX9,WT1,KIT,PDGFRA,BRCA2
GO:0007088	regulation of mitotic nuclear division	0.0003293346706500163	0.0003293346706500163	+1	APC,RB1,STAG2,ATM,ATRX,CCND1,SMC1A,SMC3
GO:0031396	regulation of protein ubiquitination	0.0003425643328902313	0.0003425643328902313	+1	PTEN,CDKN2A,FBXW7,AKT1,BRCA1,LRRK2,TAF1,RPL5
GO:0007179	transforming growth factor beta receptor signaling pathway	0.0003568491211433907	0.0003568491211433907	+1	STK11,EP300,SMAD4,USP9X,TGFBR2,ACVR1B,ACVR2A,SMAD2
GO:0045137	development of primary sexual characteristics	0.00035709497409755264	0.00035709497409755264	+1	GATA3,SOX9,WT1,KIT,PDGFRA,BRCA2
GO:1901800	positive regulation of proteasomal protein catabolic process	0.00035709497409755264	0.00035709497409755264	+1	FBXW7,KEAP1,NFE2L2,CEBPA,LRRK2,TAF1
GO:1903039	positive regulation of leukocyte cell-cell adhesion	0.00036924431082854857	0.00036924431082854857	+1	PIK3CA,PIK3R1,GATA3,RUNX1,AKT1,TGFBR2,CBFB,PTPN11
GO:0003007	heart morphogenesis	0.00036924431082854857	0.00036924431082854857	+1	GATA3,NOTCH1,CTNNB1,SOX9,FGFR2,SMAD4,TGFBR2,SOX17
GO:0010518	positive regulation of phospholipase activity	0.00037090001778806075	0.00037090001778806075	+1	EGFR,KIT,PDGFRA,FGFR2,FGFR3
GO:0070601	centromeric sister chromatid cohesion	0.0003827862479911361	0.0003827862479911361	+1	CTNNB1,CTCF,AXIN2
GO:0003176	aortic valve development	0.00038556195800359527	0.00038556195800359527	+1	GATA3,RB1,NOTCH1,SOX9
GO:0048562	embryonic organ morphogenesis	0.0004145311243591756	0.0004145311243591756	+1	NOTCH1,CTNNB1,SOX9,PDGFRA,FGFR2,TGFBR2,SOX17
GO:1904882	regulation of telomerase catalytic core complex assembly	0.0004255894346888859	0.0004255894346888859	+1	ATM,ATR
GO:1905179	negative regulation of cardiac muscle tissue regeneration	0.0004255894346888859	0.0004255894346888859	+1	CDKN1B,CDKN1A
GO:1904884	positive regulation of telomerase catalytic core complex assembly	0.0004255894346888859	0.0004255894346888859	+1	ATM,ATR
GO:0060737	prostate gland morphogenetic growth	0.0004255894346888859	0.0004255894346888859	+1	SOX9,FGFR2
GO:1904868	telomerase catalytic core complex assembly	0.0004255894346888859	0.0004255894346888859	+1	ATM,ATR
GO:0051548	negative regulation of keratinocyte migration	0.0004255894346888859	0.0004255894346888859	+1	PTEN,EPPK1
GO:0048145	regulation of fibroblast proliferation	0.0004358719831683749	0.0004358719831683749	+1	TP53,NF1,CTNNB1,PDGFRA,CDKN1A
GO:0003208	cardiac ventricle morphogenesis	0.0004358719831683749	0.0004358719831683749	+1	GATA3,NOTCH1,FGFR2,SMAD4,TGFBR2
GO:0043552	positive regulation of phosphatidylinositol 3-kinase activity	0.0004379920992775811	0.0004379920992775811	+1	FLT3,KIT,PDGFRA,FGFR3
GO:1902275	regulation of chromatin organization	0.0004480934019674347	0.0004480934019674347	+1	CTNNB1,ATRX,BRCA1,HIST1H1C,SMAD4,SIN3A,NSD1
GO:0071453	cellular response to oxygen levels	0.0004480934019674347	0.0004480934019674347	+1	TP53,VHL,NOTCH1,NFE2L2,AJUBA,MTOR,EP300
GO:1905330	regulation of morphogenesis of an epithelium	0.0004480934019674347	0.0004480934019674347	+1	PTEN,GATA3,SOX9,HGF,MTOR,FGFR2
GO:0046661	male sex differentiation	0.0004669404306860316	0.0004669404306860316	+1	GATA3,TBX3,SOX9,WT1,KIT
GO:0048144	fibroblast proliferation	0.0004669404306860316	0.0004669404306860316	+1	TP53,NF1,CTNNB1,PDGFRA,CDKN1A
GO:0046620	regulation of organ growth	0.0004669404306860316	0.0004669404306860316	+1	PTEN,NOTCH1,WT1,ERBB4,FGFR2
GO:0051783	regulation of nuclear division	0.00047010559130672907	0.00047010559130672907	+1	APC,RB1,STAG2,ATM,ATRX,CCND1,SMC1A,SMC3
GO:0070198	protein localization to chromosome, telomeric region	0.0004908252775224952	0.0004908252775224952	+1	ATM,ATRX,BRCA2,ATR
GO:0060412	ventricular septum morphogenesis	0.0004908252775224952	0.0004908252775224952	+1	NOTCH1,FGFR2,SMAD4,TGFBR2
GO:0018023	peptidyl-lysine trimethylation	0.0004908252775224952	0.0004908252775224952	+1	TET2,ATRX,HIST1H1C,SETD2
GO:0002053	positive regulation of mesenchymal cell proliferation	0.0004965601118373556	0.0004965601118373556	+1	SOX9,FGFR2,TGFBR2
GO:1902105	regulation of leukocyte differentiation	0.0005436504921446315	0.0005436504921446315	+1	CDKN2A,GATA3,FBXW7,RUNX1,MTOR,TLR4,TGFBR2,CBFB
GO:0002573	myeloid leukocyte differentiation	0.0005532889874844421	0.0005532889874844421	+1	FBXW7,RUNX1,CEBPA,MTOR,TLR4,KIT,TGFBR2
GO:0007259	receptor signaling pathway via JAK-STAT	0.0005532889874844421	0.0005532889874844421	+1	VHL,NOTCH1,FLT3,ERBB4,KIT,FGFR3,PPP2R1A
GO:0010828	positive regulation of glucose transmembrane transport	0.0005564934229312522	0.0005564934229312522	+1	PIK3R1,AKT1,BRAF,PTPN11
GO:0048709	oligodendrocyte differentiation	0.0005564934229312522	0.0005564934229312522	+1	PTEN,NF1,NOTCH1,SOX9
GO:0048568	embryonic organ development	0.0005606566057536531	0.0005606566057536531	+1	NOTCH1,CTNNB1,SOX9,KIT,PDGFRA,FGFR2,TGFBR2,SOX17
GO:0051101	regulation of DNA binding	0.0005862145220629472	0.0005862145220629472	+1	GATA3,RB1,CTNNB1,TAF1,SIN3A,NSD1
GO:0031056	regulation of histone modification	0.0005862145220629472	0.0005862145220629472	+1	CTNNB1,ATRX,BRCA1,SMAD4,SIN3A,NSD1
GO:1903037	regulation of leukocyte cell-cell adhesion	0.0005896246025887732	0.0005896246025887732	+1	PIK3CA,PIK3R1,CDKN2A,GATA3,RUNX1,AKT1,TGFBR2,CBFB,PTPN11
GO:0061418	regulation of transcription from RNA polymerase II promoter in response to hypoxia	0.0006279145516068602	0.0006279145516068602	+1	VHL,NOTCH1,NFE2L2,EP300
GO:0038128	ERBB2 signaling pathway	0.0006279145516068602	0.0006279145516068602	+1	PIK3CA,EGFR,PIK3R1,ERBB4
GO:0007405	neuroblast proliferation	0.0006279145516068602	0.0006279145516068602	+1	NF1,CTNNB1,LRRK2,FGFR2
GO:0048754	branching morphogenesis of an epithelial tube	0.0006332779455175939	0.0006332779455175939	+1	CTNNB1,SOX9,WT1,FGFR2,TGFBR2
GO:0051547	regulation of keratinocyte migration	0.0006413738194521903	0.0006413738194521903	+1	PTEN,EPPK1,MTOR
GO:0030850	prostate gland development	0.0006413738194521903	0.0006413738194521903	+1	AR,SOX9,FGFR2
GO:0097696	receptor signaling pathway via STAT	0.000649699542609688	0.000649699542609688	+1	VHL,NOTCH1,FLT3,ERBB4,KIT,FGFR3,PPP2R1A
GO:0032481	positive regulation of type I interferon production	0.0006778216234915851	0.0006778216234915851	+1	CTNNB1,TLR4,SETD2,EP300,PTPN11
GO:0090218	positive regulation of lipid kinase activity	0.0007019640349454501	0.0007019640349454501	+1	FLT3,KIT,PDGFRA,FGFR3
GO:0090092	regulation of transmembrane receptor protein serine/threonine kinase signaling pathway	0.0007105821623271712	0.0007105821623271712	+1	NOTCH1,STK11,EP300,SMAD4,TGFBR2,ACVR1B,ACVR2A,SMAD2
GO:0048565	digestive tract development	0.0007279708514580757	0.0007279708514580757	+1	GATA3,KIT,PDGFRA,FGFR2,SOX17
GO:0003279	cardiac septum development	0.0007279708514580757	0.0007279708514580757	+1	GATA3,NOTCH1,FGFR2,SMAD4,TGFBR2
GO:0001708	cell fate specification	0.0007825079624757519	0.0007825079624757519	+1	APC,SOX9,FOXA2,SOX17
GO:0010517	regulation of phospholipase activity	0.0007825079624757519	0.0007825079624757519	+1	EGFR,KIT,PDGFRA,FGFR2,FGFR3
GO:0046622	positive regulation of organ growth	0.0007825079624757519	0.0007825079624757519	+1	NOTCH1,WT1,ERBB4,FGFR2
GO:0060193	positive regulation of lipase activity	0.0007825079624757519	0.0007825079624757519	+1	EGFR,KIT,PDGFRA,FGFR2,FGFR3
GO:0060421	positive regulation of heart growth	0.0007825079624757519	0.0007825079624757519	+1	NOTCH1,WT1,ERBB4,FGFR2
GO:0071902	positive regulation of protein serine/threonine kinase activity	0.0007825079624757519	0.0007825079624757519	+1	EGFR,FLT3,MAP2K4,PIK3CG,TLR4,LRRK2,KIT,CCND1,EZH2
GO:0050731	positive regulation of peptidyl-tyrosine phosphorylation	0.0007941346254007585	0.0007941346254007585	+1	TP53,FBXW7,FLT3,HGF,ERBB4,KIT,FGFR3
GO:0045662	negative regulation of myoblast differentiation	0.0008007157272126493	0.0008007157272126493	+1	NOTCH1,TBX3,SOX9
GO:0051571	positive regulation of histone H3-K4 methylation	0.0008007157272126493	0.0008007157272126493	+1	CTNNB1,BRCA1,SMAD4
GO:2001185	regulation of CD8-positive, alpha-beta T cell activation	0.0008007157272126493	0.0008007157272126493	+1	RUNX1,CBFB,MAPK8IP1
GO:0055123	digestive system development	0.0008310853187970512	0.0008310853187970512	+1	GATA3,KIT,PDGFRA,FGFR2,SOX17
GO:0042246	tissue regeneration	0.0008682214267514939	0.0008682214267514939	+1	EPPK1,CDKN1B,ERBB4,CDKN1A
GO:0010507	negative regulation of autophagy	0.0008917979520565585	0.0008917979520565585	+1	PIK3CA,AKT1,HGF,MTOR,LRRK2
GO:0061045	negative regulation of wound healing	0.0008917979520565585	0.0008917979520565585	+1	PTEN,EPPK1,CDKN1B,PDGFRA,CDKN1A
GO:0043406	positive regulation of MAP kinase activity	0.0009201911726509016	0.0009201911726509016	+1	EGFR,FLT3,MAP2K4,PIK3CG,TLR4,LRRK2,KIT,EZH2
GO:0071241	cellular response to inorganic substance	0.0009281774249020225	0.0009281774249020225	+1	EGFR,CDH1,AKT1,BRAF,CDKN1B,ATRX,LRRK2
GO:1905314	semi-lunar valve development	0.0009654241097902358	0.0009654241097902358	+1	GATA3,RB1,NOTCH1,SOX9
GO:0048872	homeostasis of number of cells	0.0009691114102526481	0.0009691114102526481	+1	FLT3,AKT1,SOX9,KIT,ACVR1B,ACVR2A
GO:0003214	cardiac left ventricle morphogenesis	0.0009932402446585823	0.0009932402446585823	+1	NOTCH1,SMAD4,TGFBR2
GO:0008585	female gonad development	0.0010633223027771525	0.0010633223027771525	+1	WT1,KIT,PDGFRA,BRCA2
GO:0043627	response to estrogen	0.0010633223027771525	0.0010633223027771525	+1	GATA3,CRIPAK,BRCA1,EP300
GO:0097327	response to antineoplastic agent	0.0010633223027771525	0.0010633223027771525	+1	CTNNB1,CDH1,ATRX,BRCA1
GO:1901532	regulation of hematopoietic progenitor cell differentiation	0.0010633223027771525	0.0010633223027771525	+1	GATA3,NOTCH1,RUNX1,CBFB
GO:0072132	mesenchyme morphogenesis	0.0010633223027771525	0.0010633223027771525	+1	NOTCH1,SOX9,TGFBR2,SMAD2
GO:0060445	branching involved in salivary gland morphogenesis	0.001103890420035199	0.001103890420035199	+1	HGF,FGFR2
GO:2000435	negative regulation of protein neddylation	0.001103890420035199	0.001103890420035199	+1	CDKN2A,RPL5
GO:0097694	establishment of RNA localization to telomere	0.001103890420035199	0.001103890420035199	+1	ATM,ATR
GO:0033600	negative regulation of mammary gland epithelial cell proliferation	0.001103890420035199	0.001103890420035199	+1	GATA3,BRCA2
GO:0010226	response to lithium ion	0.001103890420035199	0.001103890420035199	+1	CDH1,CDKN1B
GO:0071285	cellular response to lithium ion	0.001103890420035199	0.001103890420035199	+1	CDH1,CDKN1B
GO:0097695	establishment of protein-containing complex localization to telomere	0.001103890420035199	0.001103890420035199	+1	ATM,ATR
GO:0032436	positive regulation of proteasomal ubiquitin-dependent protein catabolic process	0.0011452900100427672	0.0011452900100427672	+1	KEAP1,NFE2L2,CEBPA,LRRK2,TAF1
GO:0001889	liver development	0.0011605831043389452	0.0011605831043389452	+1	NF1,FBXW7,CEBPA,ARID5B
GO:0046545	development of primary female sexual characteristics	0.0011605831043389452	0.0011605831043389452	+1	WT1,KIT,PDGFRA,BRCA2
GO:0090183	regulation of kidney development	0.0011605831043389452	0.0011605831043389452	+1	GATA3,CTNNB1,SOX9,WT1
GO:0061213	positive regulation of mesonephros development	0.0011874899150671196	0.0011874899150671196	+1	GATA3,SOX9,WT1
GO:1903798	regulation of production of miRNAs involved in gene silencing by miRNA	0.0011874899150671196	0.0011874899150671196	+1	TP53,EGFR,NCOR1
GO:1902692	regulation of neuroblast proliferation	0.0011874899150671196	0.0011874899150671196	+1	NF1,CTNNB1,LRRK2
GO:0010464	regulation of mesenchymal cell proliferation	0.0011874899150671196	0.0011874899150671196	+1	SOX9,FGFR2,TGFBR2
GO:0051546	keratinocyte migration	0.0011874899150671196	0.0011874899150671196	+1	PTEN,EPPK1,MTOR
GO:0030856	regulation of epithelial cell differentiation	0.0012032822080306393	0.0012032822080306393	+1	GATA3,CTNNB1,RUNX1,SOX9,CBFB,VEZF1
GO:1902106	negative regulation of leukocyte differentiation	0.0012074471868326448	0.0012074471868326448	+1	CDKN2A,FBXW7,RUNX1,TLR4,CBFB
GO:0042509	regulation of tyrosine phosphorylation of STAT protein	0.0012074471868326448	0.0012074471868326448	+1	FLT3,ERBB4,KIT,FGFR3,PPP2R1A
GO:0035051	cardiocyte differentiation	0.0012543411416841782	0.0012543411416841782	+1	EGFR,NOTCH1,WT1,PDGFRA,SMAD4,SOX17
GO:0034614	cellular response to reactive oxygen species	0.0012543411416841782	0.0012543411416841782	+1	EGFR,NFE2L2,AKT1,HGF,LRRK2,PDGFRA
GO:0060968	regulation of gene silencing	0.0012543411416841782	0.0012543411416841782	+1	TP53,EGFR,AJUBA,HIST1H1C,SIN3A,NCOR1
GO:0061008	hepaticobiliary system development	0.0012632526984685697	0.0012632526984685697	+1	NF1,FBXW7,CEBPA,ARID5B
GO:0048704	embryonic skeletal system morphogenesis	0.0012632526984685697	0.0012632526984685697	+1	CTNNB1,PDGFRA,FGFR2,TGFBR2
GO:0072073	kidney epithelium development	0.0012773848391908643	0.0012773848391908643	+1	GATA3,CTNNB1,SOX9,WT1,FGFR2
GO:1903707	negative regulation of hemopoiesis	0.0013050990876565763	0.0013050990876565763	+1	CDKN2A,NOTCH1,FBXW7,RUNX1,TLR4,CBFB
GO:0048705	skeletal system morphogenesis	0.0013050990876565763	0.0013050990876565763	+1	CTNNB1,SOX9,PDGFRA,FGFR2,FGFR3,TGFBR2
GO:0045834	positive regulation of lipid metabolic process	0.0013050990876565763	0.0013050990876565763	+1	FLT3,AKT1,MTOR,KIT,PDGFRA,FGFR3
GO:1902749	regulation of cell cycle G2/M phase transition	0.0013053074209571295	0.0013053074209571295	+1	TP53,CDKN2A,NPM1,ATM,BRCA1,CCND1,PPP2R1A
GO:2000379	positive regulation of reactive oxygen species metabolic process	0.0013539488998096467	0.0013539488998096467	+1	TP53,AKT1,TLR4,TGFBR2,CDKN1A
GO:1903321	negative regulation of protein modification by small protein conjugation or removal	0.0013539488998096467	0.0013539488998096467	+1	CDKN2A,CTNNB1,AKT1,TAF1,RPL5
GO:0031929	TOR signaling	0.0013631522342625344	0.0013631522342625344	+1	PIK3CA,GATA3,STK11,AKT1,ATM,MTOR
GO:0036037	CD8-positive, alpha-beta T cell activation	0.001407861501473466	0.001407861501473466	+1	RUNX1,CBFB,MAPK8IP1
GO:0048485	sympathetic nervous system development	0.001407861501473466	0.001407861501473466	+1	NF1,GATA3,CTNNB1
GO:0070920	regulation of production of small RNA involved in gene silencing by RNA	0.001407861501473466	0.001407861501473466	+1	TP53,EGFR,NCOR1
GO:0044728	DNA methylation or demethylation	0.0014296502719400566	0.0014296502719400566	+1	DNMT3A,WT1,TET2,ATRX,USP9X
GO:1903035	negative regulation of response to wounding	0.0014296502719400566	0.0014296502719400566	+1	PTEN,EPPK1,CDKN1B,PDGFRA,CDKN1A
GO:1903727	positive regulation of phospholipid metabolic process	0.0015040209706037048	0.0015040209706037048	+1	FLT3,KIT,PDGFRA,FGFR3
GO:0007260	tyrosine phosphorylation of STAT protein	0.0015167097329568623	0.0015167097329568623	+1	FLT3,ERBB4,KIT,FGFR3,PPP2R1A
GO:0003231	cardiac ventricle development	0.0016075256651448587	0.0016075256651448587	+1	GATA3,NOTCH1,FGFR2,SMAD4,TGFBR2
GO:0002011	morphogenesis of an epithelial sheet	0.0016404710902283071	0.0016404710902283071	+1	PTEN,NOTCH1,ARHGAP35,MTOR
GO:0006310	DNA recombination	0.0017253083729972228	0.0017253083729972228	+1	ATM,BRCA1,POLQ,HIST1H1C,SETD2,BRCA2,RAD21,ERCC2
GO:0050680	negative regulation of epithelial cell proliferation	0.0017625235939093418	0.0017625235939093418	+1	NF1,GATA3,FBXW7,EPPK1,SOX9,BRCA2
GO:1901216	positive regulation of neuron death	0.0017898160057922086	0.0017898160057922086	+1	NF1,FBXW7,CTNNB1,TLR4
GO:0001657	ureteric bud development	0.0017898160057922086	0.0017898160057922086	+1	GATA3,SOX9,WT1,FGFR2
GO:0046427	positive regulation of receptor signaling pathway via JAK-STAT	0.0017983087409852892	0.0017983087409852892	+1	NOTCH1,FLT3,ERBB4,KIT,FGFR3
GO:0045927	positive regulation of growth	0.0018336620819623623	0.0018336620819623623	+1	EGFR,NOTCH1,AKT1,WT1,ERBB4,FGFR2,H3F3C
GO:0090287	regulation of cellular response to growth factor stimulus	0.0018712517685514813	0.0018712517685514813	+1	GATA3,NOTCH1,STK11,EP300,FGFR2,SMAD4,TGFBR2,SMAD2
GO:0021953	central nervous system neuron differentiation	0.0019034265754802654	0.0019034265754802654	+1	PTEN,CTNNB1,ARHGAP35,ERBB4,FGFR2
GO:1903202	negative regulation of oxidative stress-induced cell death	0.0019374387603124856	0.0019374387603124856	+1	NFE2L2,AKT1,HGF,LRRK2
GO:1900408	negative regulation of cellular response to oxidative stress	0.0019374387603124856	0.0019374387603124856	+1	NFE2L2,AKT1,HGF,LRRK2
GO:0072164	mesonephric tubule development	0.0019374387603124856	0.0019374387603124856	+1	GATA3,SOX9,WT1,FGFR2
GO:0072163	mesonephric epithelium development	0.0019374387603124856	0.0019374387603124856	+1	GATA3,SOX9,WT1,FGFR2
GO:0051569	regulation of histone H3-K4 methylation	0.0019374965046939784	0.0019374965046939784	+1	CTNNB1,BRCA1,SMAD4
GO:0071480	cellular response to gamma radiation	0.0019374965046939784	0.0019374965046939784	+1	TP53,ATM,ATR
GO:0070200	establishment of protein localization to telomere	0.0019374965046939784	0.0019374965046939784	+1	ATM,BRCA2,ATR
GO:0048701	embryonic cranial skeleton morphogenesis	0.0019374965046939784	0.0019374965046939784	+1	PDGFRA,FGFR2,TGFBR2
GO:0061217	regulation of mesonephros development	0.0019374965046939784	0.0019374965046939784	+1	GATA3,SOX9,WT1
GO:0062009	secondary palate development	0.0019374965046939784	0.0019374965046939784	+1	SMAD4,TGFBR2,SMAD2
GO:0071600	otic vesicle morphogenesis	0.001970675164314683	0.001970675164314683	+1	SOX9,FGFR2
GO:0030916	otic vesicle formation	0.001970675164314683	0.001970675164314683	+1	SOX9,FGFR2
GO:0035522	monoubiquitinated histone H2A deubiquitination	0.001970675164314683	0.001970675164314683	+1	BAP1,ASXL1
GO:0035521	monoubiquitinated histone deubiquitination	0.001970675164314683	0.001970675164314683	+1	BAP1,ASXL1
GO:0060740	prostate gland epithelium morphogenesis	0.001970675164314683	0.001970675164314683	+1	SOX9,FGFR2
GO:0008630	intrinsic apoptotic signaling pathway in response to DNA damage	0.001970675164314683	0.001970675164314683	+1	TP53,ATM,BRCA1,CHEK2,EP300
GO:1903223	positive regulation of oxidative stress-induced neuron death	0.001970675164314683	0.001970675164314683	+1	FBXW7,TLR4
GO:2000617	positive regulation of histone H3-K9 acetylation	0.001970675164314683	0.001970675164314683	+1	BRCA1,SMAD4
GO:0006102	isocitrate metabolic process	0.001970675164314683	0.001970675164314683	+1	IDH1,IDH2
GO:2000434	regulation of protein neddylation	0.001970675164314683	0.001970675164314683	+1	CDKN2A,RPL5
GO:0043378	positive regulation of CD8-positive, alpha-beta T cell differentiation	0.001970675164314683	0.001970675164314683	+1	RUNX1,CBFB
GO:0031668	cellular response to extracellular stimulus	0.001978359251306713	0.001978359251306713	+1	TP53,ARHGAP35,MTOR,LRRK2,FOXA2,CDKN1A,TAF1
GO:0035196	production of miRNAs involved in gene silencing by miRNA	0.002056598445312863	0.002056598445312863	+1	TP53,EGFR,NCOR1,SMAD2
GO:0001570	vasculogenesis	0.002056598445312863	0.002056598445312863	+1	NOTCH1,WT1,TGFBR2,SOX17
GO:1904894	positive regulation of receptor signaling pathway via STAT	0.002067773126255734	0.002067773126255734	+1	NOTCH1,FLT3,ERBB4,KIT,FGFR3
GO:0071773	cellular response to BMP stimulus	0.002099296972483747	0.002099296972483747	+1	NOTCH1,SOX9,SMAD4,USP9X,ACVR2A,SMAD2
GO:0007219	Notch signaling pathway	0.002099296972483747	0.002099296972483747	+1	EGFR,NOTCH1,FBXW7,AKT1,ELF3,EP300
GO:0071772	response to BMP	0.002099296972483747	0.002099296972483747	+1	NOTCH1,SOX9,SMAD4,USP9X,ACVR2A,SMAD2
GO:0032925	regulation of activin receptor signaling pathway	0.0022172498555481095	0.0022172498555481095	+1	ACVR1B,ACVR2A,SMAD2
GO:1901673	regulation of mitotic spindle assembly	0.0022172498555481095	0.0022172498555481095	+1	STAG2,SMC1A,SMC3
GO:1900034	regulation of cellular response to heat	0.0022172498555481095	0.0022172498555481095	+1	ATM,MTOR,EP300,ATR
GO:1902883	negative regulation of response to oxidative stress	0.0022172498555481095	0.0022172498555481095	+1	NFE2L2,AKT1,HGF,LRRK2
GO:0033157	regulation of intracellular protein transport	0.002236405257449343	0.002236405257449343	+1	TP53,PIK3R1,FBXW7,CDH1,BAP1,LRRK2,SETD2
GO:0030098	lymphocyte differentiation	0.002251746575283605	0.002251746575283605	+1	CDKN2A,GATA3,FLT3,RUNX1,ATM,KIT,TGFBR2,CBFB
GO:2001251	negative regulation of chromosome organization	0.002260229811654346	0.002260229811654346	+1	APC,ATM,ATRX,BRCA1,HIST1H1C,SIN3A
GO:0003206	cardiac chamber morphogenesis	0.002279504458437275	0.002279504458437275	+1	GATA3,NOTCH1,FGFR2,SMAD4,TGFBR2
GO:0006383	transcription by RNA polymerase III	0.002367327559609512	0.002367327559609512	+1	CEBPA,AR,MTOR,BRCA1
GO:0009798	axis specification	0.002367327559609512	0.002367327559609512	+1	TBX3,WT1,FOXA2,SMAD2
GO:0070918	production of small RNA involved in gene silencing by RNA	0.002367327559609512	0.002367327559609512	+1	TP53,EGFR,NCOR1,SMAD2
GO:0060420	regulation of heart growth	0.002367327559609512	0.002367327559609512	+1	NOTCH1,WT1,ERBB4,FGFR2
GO:0031295	T cell costimulation	0.002367327559609512	0.002367327559609512	+1	PIK3CA,PIK3R1,AKT1,PTPN11
GO:0031050	dsRNA processing	0.002367327559609512	0.002367327559609512	+1	TP53,EGFR,NCOR1,SMAD2
GO:0001503	ossification	0.002367327559609512	0.002367327559609512	+1	EGFR,NF1,NOTCH1,SOX9,HGF,FGFR2,FGFR3,ACVR2A
GO:1903076	regulation of protein localization to plasma membrane	0.002381559568759738	0.002381559568759738	+1	EGFR,PIK3R1,EPHA3,AKT1,AR
GO:0030219	megakaryocyte differentiation	0.002512122153303449	0.002512122153303449	+1	RUNX1,KIT,EP300,CBFB,SIN3A
GO:0010463	mesenchymal cell proliferation	0.0025126901310522443	0.0025126901310522443	+1	SOX9,FGFR2,TGFBR2
GO:0043525	positive regulation of neuron apoptotic process	0.0025126901310522443	0.0025126901310522443	+1	NF1,FBXW7,CTNNB1
GO:1904666	regulation of ubiquitin protein ligase activity	0.0025126901310522443	0.0025126901310522443	+1	PTEN,CDKN2A,RPL5
GO:1905332	positive regulation of morphogenesis of an epithelium	0.0025126901310522443	0.0025126901310522443	+1	GATA3,SOX9,MTOR
GO:2000637	positive regulation of gene silencing by miRNA	0.0025126901310522443	0.0025126901310522443	+1	TP53,EGFR,AJUBA
GO:0031294	lymphocyte costimulation	0.0025329759661640873	0.0025329759661640873	+1	PIK3CA,PIK3R1,AKT1,PTPN11
GO:0120163	negative regulation of cold-induced thermogenesis	0.0025329759661640873	0.0025329759661640873	+1	RB1,NOTCH1,STK11,TLR4
GO:0060993	kidney morphogenesis	0.0025329759661640873	0.0025329759661640873	+1	GATA3,SOX9,WT1,LRRK2
GO:0001823	mesonephros development	0.0025329759661640873	0.0025329759661640873	+1	GATA3,SOX9,WT1,FGFR2
GO:1903708	positive regulation of hemopoiesis	0.002595592315751364	0.002595592315751364	+1	GATA3,RUNX1,TGFBR2,CBFB,ACVR1B,ACVR2A
GO:0072006	nephron development	0.002611158707220957	0.002611158707220957	+1	GATA3,CTNNB1,SOX9,WT1,PDGFRA
GO:0090263	positive regulation of canonical Wnt signaling pathway	0.002611158707220957	0.002611158707220957	+1	EGFR,LRRK2,FGFR2,TBL1XR1,AXIN2
GO:0072080	nephron tubule development	0.0027123648818943203	0.0027123648818943203	+1	GATA3,CTNNB1,SOX9,WT1
GO:0071260	cellular response to mechanical stimulus	0.0027123648818943203	0.0027123648818943203	+1	MAP3K1,MAP2K4,SOX9,TLR4
GO:0008584	male gonad development	0.0027123648818943203	0.0027123648818943203	+1	GATA3,SOX9,WT1,KIT
GO:0060191	regulation of lipase activity	0.0027331305914425766	0.0027331305914425766	+1	EGFR,KIT,PDGFRA,FGFR2,FGFR3
GO:0000086	G2/M transition of mitotic cell cycle	0.002792916436102261	0.002792916436102261	+1	CDKN2A,AJUBA,ATM,CHEK2,CCND1,CDKN1A,PPP2R1A
GO:0000578	embryonic axis specification	0.0028180179042223124	0.0028180179042223124	+1	TBX3,WT1,SMAD2
GO:0048546	digestive tract morphogenesis	0.0028180179042223124	0.0028180179042223124	+1	PDGFRA,FGFR2,SOX17
GO:0110111	negative regulation of animal organ morphogenesis	0.0028180179042223124	0.0028180179042223124	+1	GATA3,NOTCH1,FBXW7
GO:0060148	positive regulation of posttranscriptional gene silencing	0.0028180179042223124	0.0028180179042223124	+1	TP53,EGFR,AJUBA
GO:0043032	positive regulation of macrophage activation	0.0028180179042223124	0.0028180179042223124	+1	CEBPA,TLR4,MIR142
GO:0007064	mitotic sister chromatid cohesion	0.0028180179042223124	0.0028180179042223124	+1	RB1,ATRX,SMC1A
GO:0048806	genitalia development	0.0028180179042223124	0.0028180179042223124	+1	TBX3,WT1,PTPN11
GO:0030513	positive regulation of BMP signaling pathway	0.0028180179042223124	0.0028180179042223124	+1	NOTCH1,SMAD4,SMAD2
GO:2000679	positive regulation of transcription regulatory region DNA binding	0.0028180179042223124	0.0028180179042223124	+1	GATA3,RB1,CTNNB1
GO:0030168	platelet activation	0.0028519692510430373	0.0028519692510430373	+1	PIK3CA,PIK3R1,PIK3CG,TLR4,PDGFRA,PTPN11
GO:0048706	embryonic skeletal system development	0.0028606877747396173	0.0028606877747396173	+1	CTNNB1,PDGFRA,FGFR2,TGFBR2
GO:0060411	cardiac septum morphogenesis	0.0028606877747396173	0.0028606877747396173	+1	NOTCH1,FGFR2,SMAD4,TGFBR2
GO:0046546	development of primary male sexual characteristics	0.0028606877747396173	0.0028606877747396173	+1	GATA3,SOX9,WT1,KIT
GO:0061326	renal tubule development	0.0028606877747396173	0.0028606877747396173	+1	GATA3,CTNNB1,SOX9,WT1
GO:0060729	intestinal epithelial structure maintenance	0.002927603740341138	0.002927603740341138	+1	SOX9,TLR4
GO:0060736	prostate gland growth	0.002927603740341138	0.002927603740341138	+1	SOX9,FGFR2
GO:0010001	glial cell differentiation	0.002927603740341138	0.002927603740341138	+1	PTEN,NF1,NOTCH1,SOX9,MIR142
GO:2001187	positive regulation of CD8-positive, alpha-beta T cell activation	0.002927603740341138	0.002927603740341138	+1	RUNX1,CBFB
GO:2000020	positive regulation of male gonad development	0.002927603740341138	0.002927603740341138	+1	SOX9,WT1
GO:0061419	positive regulation of transcription from RNA polymerase II promoter in response to hypoxia	0.002927603740341138	0.002927603740341138	+1	NOTCH1,NFE2L2
GO:0048853	forebrain morphogenesis	0.002927603740341138	0.002927603740341138	+1	PTEN,NF1
GO:1901723	negative regulation of cell proliferation involved in kidney development	0.002927603740341138	0.002927603740341138	+1	GATA3,WT1
GO:0097305	response to alcohol	0.002927603740341138	0.002927603740341138	+1	CTNNB1,CDH1,BRCA1,TGFBR2,SMAD2
GO:0060512	prostate gland morphogenesis	0.002927603740341138	0.002927603740341138	+1	SOX9,FGFR2
GO:1902498	regulation of protein autoubiquitination	0.002927603740341138	0.002927603740341138	+1	LRRK2,TAF1
GO:0003149	membranous septum morphogenesis	0.002927603740341138	0.002927603740341138	+1	FGFR2,TGFBR2
GO:0003160	endocardium morphogenesis	0.002927603740341138	0.002927603740341138	+1	NOTCH1,SOX17
GO:0071248	cellular response to metal ion	0.002927603740341138	0.002927603740341138	+1	EGFR,CDH1,AKT1,BRAF,CDKN1B,LRRK2
GO:2000377	regulation of reactive oxygen species metabolic process	0.0030084667685434793	0.0030084667685434793	+1	TP53,AKT1,TLR4,BRCA1,TGFBR2,CDKN1A
GO:1903078	positive regulation of protein localization to plasma membrane	0.003028128467112291	0.003028128467112291	+1	EGFR,PIK3R1,EPHA3,AKT1
GO:0000302	response to reactive oxygen species	0.0031222123505357247	0.0031222123505357247	+1	EGFR,NFE2L2,AKT1,HGF,LRRK2,PDGFRA
GO:1903846	positive regulation of cellular response to transforming growth factor beta stimulus	0.0031326953176866	0.0031326953176866	+1	STK11,EP300,SMAD4
GO:0030511	positive regulation of transforming growth factor beta receptor signaling pathway	0.0031326953176866	0.0031326953176866	+1	STK11,EP300,SMAD4
GO:0043009	chordate embryonic development	0.0032250741289787293	0.0032250741289787293	+1	GATA3,CTNNB1,SOX9,BRCA1,PDGFRA,FGFR2,TGFBR2
GO:0051438	regulation of ubiquitin-protein transferase activity	0.0032391198941000066	0.0032391198941000066	+1	PTEN,CDKN2A,FBXW7,RPL5
GO:0010827	regulation of glucose transmembrane transport	0.0032391198941000066	0.0032391198941000066	+1	PIK3R1,AKT1,BRAF,PTPN11
GO:2001020	regulation of response to DNA damage stimulus	0.00342226972318322	0.00342226972318322	+1	EGFR,ATM,BRCA1,POLQ,SETD2,ATR,AXIN2
GO:0043966	histone H3 acetylation	0.0034757110285454176	0.0034757110285454176	+1	BRCA1,SMAD4,BRCA2,SIN3A
GO:0006304	DNA modification	0.0035225359256384012	0.0035225359256384012	+1	DNMT3A,WT1,TET2,ATRX,USP9X
GO:1901032	negative regulation of response to reactive oxygen species	0.003531815014153933	0.003531815014153933	+1	NFE2L2,HGF,LRRK2
GO:0071168	protein localization to chromatin	0.003531815014153933	0.003531815014153933	+1	RB1,SETD2,RAD21
GO:0072210	metanephric nephron development	0.003531815014153933	0.003531815014153933	+1	SOX9,WT1,PDGFRA
GO:2001039	negative regulation of cellular response to drug	0.003531815014153933	0.003531815014153933	+1	NFE2L2,HGF,LRRK2
GO:1903206	negative regulation of hydrogen peroxide-induced cell death	0.003531815014153933	0.003531815014153933	+1	NFE2L2,HGF,LRRK2
GO:0048738	cardiac muscle tissue development	0.0037050969708568725	0.0037050969708568725	+1	NOTCH1,WT1,ERBB4,PDGFRA,FGFR2,SMAD4
GO:1904375	regulation of protein localization to cell periphery	0.003842954373502161	0.003842954373502161	+1	EGFR,PIK3R1,EPHA3,AKT1,AR
GO:0045582	positive regulation of T cell differentiation	0.003951199796969973	0.003951199796969973	+1	GATA3,RUNX1,TGFBR2,CBFB
GO:1902175	regulation of oxidative stress-induced intrinsic apoptotic signaling pathway	0.003953277064742466	0.003953277064742466	+1	FBXW7,NFE2L2,AKT1
GO:2000144	positive regulation of DNA-templated transcription, initiation	0.003953277064742466	0.003953277064742466	+1	TP53,CTNNB1,TAF1
GO:0003148	outflow tract septum morphogenesis	0.003953277064742466	0.003953277064742466	+1	FGFR2,SMAD4,TGFBR2
GO:0048483	autonomic nervous system development	0.003953277064742466	0.003953277064742466	+1	NF1,GATA3,CTNNB1
GO:0046326	positive regulation of glucose import	0.003953277064742466	0.003953277064742466	+1	PIK3R1,AKT1,PTPN11
GO:0061647	histone H3-K9 modification	0.003953277064742466	0.003953277064742466	+1	ATRX,BRCA1,SMAD4
GO:0003205	cardiac chamber development	0.0039874043834050655	0.0039874043834050655	+1	GATA3,NOTCH1,FGFR2,SMAD4,TGFBR2
GO:0045580	regulation of T cell differentiation	0.0039874043834050655	0.0039874043834050655	+1	CDKN2A,GATA3,RUNX1,TGFBR2,CBFB
GO:0071599	otic vesicle development	0.0041224025868931615	0.0041224025868931615	+1	SOX9,FGFR2
GO:0048715	negative regulation of oligodendrocyte differentiation	0.0041224025868931615	0.0041224025868931615	+1	NF1,NOTCH1
GO:2000739	regulation of mesenchymal stem cell differentiation	0.0041224025868931615	0.0041224025868931615	+1	SOX9,PDGFRA
GO:0030539	male genitalia development	0.0041224025868931615	0.0041224025868931615	+1	TBX3,WT1
GO:0009612	response to mechanical stimulus	0.0041224025868931615	0.0041224025868931615	+1	MAP3K1,MAP2K4,SOX9,TLR4,KIT
GO:0090394	negative regulation of excitatory postsynaptic potential	0.0041224025868931615	0.0041224025868931615	+1	PTEN,LRRK2
GO:0060956	endocardial cell differentiation	0.0041224025868931615	0.0041224025868931615	+1	NOTCH1,SOX17
GO:0048755	branching morphogenesis of a nerve	0.0041224025868931615	0.0041224025868931615	+1	LRRK2,FGFR2
GO:2000018	regulation of male gonad development	0.0041224025868931615	0.0041224025868931615	+1	SOX9,WT1
GO:0043376	regulation of CD8-positive, alpha-beta T cell differentiation	0.0041224025868931615	0.0041224025868931615	+1	RUNX1,CBFB
GO:1905941	positive regulation of gonad development	0.0041224025868931615	0.0041224025868931615	+1	SOX9,WT1
GO:1905634	regulation of protein localization to chromatin	0.0041224025868931615	0.0041224025868931615	+1	RB1,SETD2
GO:0045445	myoblast differentiation	0.0041224025868931615	0.0041224025868931615	+1	RB1,NOTCH1,TBX3,SOX9
GO:1905323	telomerase holoenzyme complex assembly	0.0041224025868931615	0.0041224025868931615	+1	ATM,ATR
GO:1905178	regulation of cardiac muscle tissue regeneration	0.0041224025868931615	0.0041224025868931615	+1	CDKN1B,CDKN1A
GO:0003348	cardiac endothelial cell differentiation	0.0041224025868931615	0.0041224025868931615	+1	NOTCH1,SOX17
GO:0050679	positive regulation of epithelial cell proliferation	0.0041512085793792034	0.0041512085793792034	+1	EGFR,NRAS,AKT1,SOX9,FGFR2,EGR3
GO:0017015	regulation of transforming growth factor beta receptor signaling pathway	0.004286946820698573	0.004286946820698573	+1	STK11,EP300,SMAD4,TGFBR2,SMAD2
GO:1902036	regulation of hematopoietic stem cell differentiation	0.004336822623699663	0.004336822623699663	+1	GATA3,RUNX1,CBFB
GO:0010332	response to gamma radiation	0.004336822623699663	0.004336822623699663	+1	TP53,ATM,ATR
GO:0090169	regulation of spindle assembly	0.004336822623699663	0.004336822623699663	+1	STAG2,SMC1A,SMC3
GO:1904377	positive regulation of protein localization to cell periphery	0.004361920073266194	0.004361920073266194	+1	EGFR,PIK3R1,EPHA3,AKT1
GO:0090307	mitotic spindle assembly	0.004361920073266194	0.004361920073266194	+1	STAG2,CHEK2,SMC1A,SMC3
GO:0051225	spindle assembly	0.004447054703557899	0.004447054703557899	+1	STAG2,CHEK2,SMC1A,SMC3,NCOR1
GO:1903844	regulation of cellular response to transforming growth factor beta stimulus	0.004447054703557899	0.004447054703557899	+1	STK11,EP300,SMAD4,TGFBR2,SMAD2
GO:1905475	regulation of protein localization to membrane	0.00455725567525506	0.00455725567525506	+1	TP53,EGFR,PIK3R1,EPHA3,AKT1,AR
GO:0061136	regulation of proteasomal protein catabolic process	0.00455725567525506	0.00455725567525506	+1	FBXW7,KEAP1,NFE2L2,CEBPA,LRRK2,TAF1
GO:0070661	leukocyte proliferation	0.004605406532779171	0.004605406532779171	+1	CDKN2A,FLT3,PIK3CG,ATM,KIT,TGFBR2,MAPK8IP1
GO:0009792	embryo development ending in birth or egg hatching	0.004605406532779171	0.004605406532779171	+1	GATA3,CTNNB1,SOX9,BRCA1,PDGFRA,FGFR2,TGFBR2
GO:0018107	peptidyl-threonine phosphorylation	0.004611062706210597	0.004611062706210597	+1	AKT1,LRRK2,TGFBR2,TAF1,ACVR1B
GO:0055024	regulation of cardiac muscle tissue development	0.004611062706210597	0.004611062706210597	+1	NOTCH1,ERBB4,FGFR2,SMAD4
GO:0031214	biomineral tissue development	0.004611062706210597	0.004611062706210597	+1	NOTCH1,SOX9,FGFR2,FGFR3,ACVR2A
GO:0060045	positive regulation of cardiac muscle cell proliferation	0.004783629513626877	0.004783629513626877	+1	NOTCH1,ERBB4,FGFR2
GO:0048645	animal organ formation	0.004783629513626877	0.004783629513626877	+1	WT1,FGFR2,SOX17
GO:0032434	regulation of proteasomal ubiquitin-dependent protein catabolic process	0.0048052083070783	0.0048052083070783	+1	KEAP1,NFE2L2,CEBPA,LRRK2,TAF1
GO:0072593	reactive oxygen species metabolic process	0.004815007647344183	0.004815007647344183	+1	TP53,AKT1,TLR4,BRCA1,LRRK2,TGFBR2,CDKN1A
GO:0034329	cell junction assembly	0.004815007647344183	0.004815007647344183	+1	PTEN,APC,CTNNB1,CDH1,RUNX1,EPHA3,CBFB
GO:0030217	T cell differentiation	0.004815007647344183	0.004815007647344183	+1	CDKN2A,GATA3,RUNX1,KIT,TGFBR2,CBFB
GO:0060419	heart growth	0.004859128094324421	0.004859128094324421	+1	NOTCH1,WT1,ERBB4,FGFR2
GO:0031099	regeneration	0.004859128094324421	0.004859128094324421	+1	EPPK1,CDKN1B,ERBB4,CDKN1A
GO:0045815	positive regulation of gene expression, epigenetic	0.004859128094324421	0.004859128094324421	+1	ARID1A,HIST1H1C,EP300,SF3B1
GO:1905477	positive regulation of protein localization to membrane	0.005199127496410346	0.005199127496410346	+1	TP53,EGFR,PIK3R1,EPHA3,AKT1
GO:0009408	response to heat	0.005199127496410346	0.005199127496410346	+1	AKT1,ATM,MTOR,EP300,ATR
GO:2001024	negative regulation of response to drug	0.00525861798444844	0.00525861798444844	+1	NFE2L2,HGF,LRRK2
GO:0003203	endocardial cushion morphogenesis	0.00525861798444844	0.00525861798444844	+1	NOTCH1,SOX9,TGFBR2
GO:1903205	regulation of hydrogen peroxide-induced cell death	0.00525861798444844	0.00525861798444844	+1	NFE2L2,HGF,LRRK2
GO:0070199	establishment of protein localization to chromosome	0.00525861798444844	0.00525861798444844	+1	ATM,BRCA2,ATR
GO:0010821	regulation of mitochondrion organization	0.005265530559116862	0.005265530559116862	+1	TP53,FBXW7,BAP1,AKT1,HGF,LRRK2
GO:0008340	determination of adult lifespan	0.005406275407812781	0.005406275407812781	+1	TP53,LRRK2
GO:0035148	tube formation	0.005406275407812781	0.005406275407812781	+1	GATA3,NOTCH1,SOX9,FGFR2
GO:0043970	histone H3-K9 acetylation	0.005406275407812781	0.005406275407812781	+1	BRCA1,SMAD4
GO:1902969	mitotic DNA replication	0.005406275407812781	0.005406275407812781	+1	CHEK2,BRCA2
GO:0062043	positive regulation of cardiac epithelial to mesenchymal transition	0.005406275407812781	0.005406275407812781	+1	NOTCH1,TGFBR2
GO:0071481	cellular response to X-ray	0.005406275407812781	0.005406275407812781	+1	GATA3,ATM
GO:2000615	regulation of histone H3-K9 acetylation	0.005406275407812781	0.005406275407812781	+1	BRCA1,SMAD4
GO:1903689	regulation of wound healing, spreading of epidermal cells	0.005406275407812781	0.005406275407812781	+1	PTEN,MTOR
GO:0071371	cellular response to gonadotropin stimulus	0.005406275407812781	0.005406275407812781	+1	NOTCH1,WT1
GO:0060602	branch elongation of an epithelium	0.005406275407812781	0.005406275407812781	+1	SOX9,FGFR2
GO:0035270	endocrine system development	0.005406275407812781	0.005406275407812781	+1	NF1,AKT1,WT1,FOXA2
GO:0002327	immature B cell differentiation	0.005406275407812781	0.005406275407812781	+1	ATM,KIT
GO:0007435	salivary gland morphogenesis	0.005406275407812781	0.005406275407812781	+1	HGF,FGFR2
GO:0042531	positive regulation of tyrosine phosphorylation of STAT protein	0.00570232719401277	0.00570232719401277	+1	FLT3,ERBB4,KIT,FGFR3
GO:1904888	cranial skeletal system development	0.00570232719401277	0.00570232719401277	+1	PDGFRA,FGFR2,TGFBR2
GO:0071364	cellular response to epidermal growth factor stimulus	0.00570232719401277	0.00570232719401277	+1	EGFR,SOX9,PTPN11
GO:0090505	epiboly involved in wound healing	0.00570232719401277	0.00570232719401277	+1	PTEN,ARHGAP35,MTOR
GO:0010719	negative regulation of epithelial to mesenchymal transition	0.00570232719401277	0.00570232719401277	+1	PTEN,FOXA1,FOXA2
GO:0090184	positive regulation of kidney development	0.00570232719401277	0.00570232719401277	+1	GATA3,SOX9,WT1
GO:0031062	positive regulation of histone methylation	0.00570232719401277	0.00570232719401277	+1	CTNNB1,BRCA1,SMAD4
GO:0045621	positive regulation of lymphocyte differentiation	0.00570232719401277	0.00570232719401277	+1	GATA3,RUNX1,TGFBR2,CBFB
GO:0009948	anterior/posterior axis specification	0.00570232719401277	0.00570232719401277	+1	TBX3,WT1,FOXA2
GO:0044319	wound healing, spreading of cells	0.00570232719401277	0.00570232719401277	+1	PTEN,ARHGAP35,MTOR
GO:0032479	regulation of type I interferon production	0.005726476457647889	0.005726476457647889	+1	CTNNB1,TLR4,SETD2,EP300,PTPN11
GO:0032606	type I interferon production	0.005726476457647889	0.005726476457647889	+1	CTNNB1,TLR4,SETD2,EP300,PTPN11
GO:0031334	positive regulation of protein complex assembly	0.005761682616791363	0.005761682616791363	+1	TP53,NAV3,AJUBA,ATM,TLR4,ATR,ERCC2
GO:0060537	muscle tissue development	0.005901984466297662	0.005901984466297662	+1	NF1,NOTCH1,WT1,ERBB4,PDGFRA,FGFR2,SMAD4
GO:0006289	nucleotide-excision repair	0.00593839961990732	0.00593839961990732	+1	TP53,CRIPAK,EP300,BRCA2,ERCC2
GO:0090398	cellular senescence	0.005958296795635721	0.005958296795635721	+1	TP53,CDKN2A,TBX3,CDKN1A
GO:0018210	peptidyl-threonine modification	0.0061618943640033095	0.0061618943640033095	+1	AKT1,LRRK2,TGFBR2,TAF1,ACVR1B
GO:0060348	bone development	0.0061618943640033095	0.0061618943640033095	+1	FBXW7,SOX9,KIT,FGFR2,FGFR3
GO:0008286	insulin receptor signaling pathway	0.0061618943640033095	0.0061618943640033095	+1	PIK3CA,APC,PIK3R1,AKT1,PTPN11
GO:0031669	cellular response to nutrient levels	0.006177453271151347	0.006177453271151347	+1	TP53,MTOR,LRRK2,FOXA2,CDKN1A,TAF1
GO:0035019	somatic stem cell population maintenance	0.006206780733705433	0.006206780733705433	+1	SOX9,SMAD4,SMAD2
GO:2001038	regulation of cellular response to drug	0.006206780733705433	0.006206780733705433	+1	NFE2L2,HGF,LRRK2
GO:0045746	negative regulation of Notch signaling pathway	0.006206780733705433	0.006206780733705433	+1	EGFR,FBXW7,AKT1
GO:0090504	epiboly	0.006206780733705433	0.006206780733705433	+1	PTEN,ARHGAP35,MTOR
GO:0032526	response to retinoic acid	0.006246197624939003	0.006246197624939003	+1	EPHA3,SOX9,ATM,ASXL1
GO:0033047	regulation of mitotic sister chromatid segregation	0.006246197624939003	0.006246197624939003	+1	APC,RB1,ATM,ATRX
GO:0048640	negative regulation of developmental growth	0.006246197624939003	0.006246197624939003	+1	PTEN,CDKN1B,FGFR3,CDKN1A
GO:0007423	sensory organ development	0.006298970901079297	0.006298970901079297	+1	NF1,GATA3,SOX9,WT1,PDGFRA,FGFR2,PTPN11
GO:0030177	positive regulation of Wnt signaling pathway	0.006351692352029052	0.006351692352029052	+1	EGFR,LRRK2,FGFR2,TBL1XR1,AXIN2
GO:0008637	apoptotic mitochondrial changes	0.006351692352029052	0.006351692352029052	+1	TP53,CDKN2A,AKT1,HGF,ERBB4
GO:0051236	establishment of RNA localization	0.006508691652535844	0.006508691652535844	+1	NPM1,ATM,U2AF1,SETD2,TGFBR2,ATR
GO:0072009	nephron epithelium development	0.006575498590004399	0.006575498590004399	+1	GATA3,CTNNB1,SOX9,WT1
GO:0031397	negative regulation of protein ubiquitination	0.006575498590004399	0.006575498590004399	+1	CDKN2A,AKT1,TAF1,RPL5
GO:0010259	multicellular organism aging	0.006701530871790451	0.006701530871790451	+1	TP53,LRRK2
GO:2000826	regulation of heart morphogenesis	0.006701530871790451	0.006701530871790451	+1	NOTCH1,CTNNB1,TGFBR2
GO:0007431	salivary gland development	0.006701530871790451	0.006701530871790451	+1	HGF,FGFR2
GO:0034698	response to gonadotropin	0.006701530871790451	0.006701530871790451	+1	NOTCH1,WT1
GO:2000049	positive regulation of cell-cell adhesion mediated by cadherin	0.006701530871790451	0.006701530871790451	+1	FOXA1,FOXA2
GO:0055023	positive regulation of cardiac muscle tissue growth	0.006701530871790451	0.006701530871790451	+1	NOTCH1,ERBB4,FGFR2
GO:0060644	mammary gland epithelial cell differentiation	0.006701530871790451	0.006701530871790451	+1	AKT1,ERBB4
GO:0033599	regulation of mammary gland epithelial cell proliferation	0.006701530871790451	0.006701530871790451	+1	GATA3,BRCA2
GO:1903025	regulation of RNA polymerase II regulatory region sequence-specific DNA binding	0.006701530871790451	0.006701530871790451	+1	TAF1,NSD1
GO:0090400	stress-induced premature senescence	0.006701530871790451	0.006701530871790451	+1	TP53,CDKN1A
GO:0003157	endocardium development	0.006701530871790451	0.006701530871790451	+1	NOTCH1,SOX17
GO:0072497	mesenchymal stem cell differentiation	0.006701530871790451	0.006701530871790451	+1	SOX9,PDGFRA
GO:1901722	regulation of cell proliferation involved in kidney development	0.006701530871790451	0.006701530871790451	+1	GATA3,WT1
GO:0140052	cellular response to oxidised low-density lipoprotein particle stimulus	0.006701530871790451	0.006701530871790451	+1	AKT1,TLR4
GO:0036092	phosphatidylinositol-3-phosphate biosynthetic process	0.006701530871790451	0.006701530871790451	+1	PIK3CA,PIK3CG
GO:0043374	CD8-positive, alpha-beta T cell differentiation	0.006701530871790451	0.006701530871790451	+1	RUNX1,CBFB
GO:0072239	metanephric glomerulus vasculature development	0.006701530871790451	0.006701530871790451	+1	WT1,PDGFRA
GO:0062042	regulation of cardiac epithelial to mesenchymal transition	0.006701530871790451	0.006701530871790451	+1	NOTCH1,TGFBR2
GO:0071493	cellular response to UV-B	0.006701530871790451	0.006701530871790451	+1	STK11,CDKN1A
GO:1904837	beta-catenin-TCF complex assembly	0.006701530871790451	0.006701530871790451	+1	CTNNB1,EP300,AXIN2
GO:0016573	histone acetylation	0.006701530871790451	0.006701530871790451	+1	BRCA1,EP300,SMAD4,BRCA2,SIN3A
GO:0032071	regulation of endodeoxyribonuclease activity	0.006701530871790451	0.006701530871790451	+1	NPM1,AKT1
GO:0006975	DNA damage induced protein phosphorylation	0.006701530871790451	0.006701530871790451	+1	ATM,CHEK2
GO:0071542	dopaminergic neuron differentiation	0.006701530871790451	0.006701530871790451	+1	CTNNB1,FOXA1,FOXA2
GO:0061351	neural precursor cell proliferation	0.006751103873321859	0.006751103873321859	+1	NF1,CTNNB1,LRRK2,FGFR2
GO:0043583	ear development	0.006751103873321859	0.006751103873321859	+1	GATA3,SOX9,FGFR2,PTPN11
GO:1901214	regulation of neuron death	0.006916027188146578	0.006916027188146578	+1	NF1,FBXW7,CTNNB1,AKT1,TLR4,LRRK2
GO:0048660	regulation of smooth muscle cell proliferation	0.006916027188146578	0.006916027188146578	+1	PTEN,CTNNB1,AKT1,CDKN1B,CDKN1A
GO:0097191	extrinsic apoptotic signaling pathway	0.0071016056889529776	0.0071016056889529776	+1	PTEN,AKT1,AR,BRCA1,FGFR3,ACVR1B
GO:1903747	regulation of establishment of protein localization to mitochondrion	0.0071016056889529776	0.0071016056889529776	+1	TP53,FBXW7,BAP1,LRRK2
GO:2000142	regulation of DNA-templated transcription, initiation	0.00711584651765224	0.00711584651765224	+1	TP53,CTNNB1,TAF1
GO:0036474	cell death in response to hydrogen peroxide	0.00711584651765224	0.00711584651765224	+1	NFE2L2,HGF,LRRK2
GO:0033144	negative regulation of intracellular steroid hormone receptor signaling pathway	0.00711584651765224	0.00711584651765224	+1	CRIPAK,BRCA1,NCOR1
GO:0060675	ureteric bud morphogenesis	0.00711584651765224	0.00711584651765224	+1	GATA3,SOX9,WT1
GO:0060218	hematopoietic stem cell differentiation	0.00711584651765224	0.00711584651765224	+1	GATA3,RUNX1,CBFB
GO:1902893	regulation of pri-miRNA transcription by RNA polymerase II	0.00711584651765224	0.00711584651765224	+1	TP53,SOX9,WT1
GO:0048708	astrocyte differentiation	0.00711584651765224	0.00711584651765224	+1	NF1,NOTCH1,MIR142
GO:0070849	response to epidermal growth factor	0.00711584651765224	0.00711584651765224	+1	EGFR,SOX9,PTPN11
GO:0045685	regulation of glial cell differentiation	0.00711584651765224	0.00711584651765224	+1	NF1,NOTCH1,MIR142
GO:1902116	negative regulation of organelle assembly	0.00711584651765224	0.00711584651765224	+1	BRCA1,LRRK2,SMAD4
GO:0070741	response to interleukin-6	0.00711584651765224	0.00711584651765224	+1	SMAD4,FOXA2,PTPN11
GO:1903322	positive regulation of protein modification by small protein conjugation or removal	0.007328416874434906	0.007328416874434906	+1	PTEN,CDKN2A,FBXW7,BRCA1,LRRK2
GO:0051494	negative regulation of cytoskeleton organization	0.007328416874434906	0.007328416874434906	+1	APC,NAV3,NPM1,BRCA1,SMAD4
GO:0048659	smooth muscle cell proliferation	0.007328416874434906	0.007328416874434906	+1	PTEN,CTNNB1,AKT1,CDKN1B,CDKN1A
GO:0018393	internal peptidyl-lysine acetylation	0.007328416874434906	0.007328416874434906	+1	BRCA1,EP300,SMAD4,BRCA2,SIN3A
GO:1904659	glucose transmembrane transport	0.007369645731565643	0.007369645731565643	+1	PIK3R1,AKT1,BRAF,PTPN11
GO:0006282	regulation of DNA repair	0.007605842742281657	0.007605842742281657	+1	EGFR,BRCA1,POLQ,SETD2,AXIN2
GO:0031648	protein destabilization	0.0077323194774681385	0.0077323194774681385	+1	CDKN2A,EP300,SOX17
GO:0046634	regulation of alpha-beta T cell activation	0.00774614458474273	0.00774614458474273	+1	RUNX1,TGFBR2,CBFB,MAPK8IP1
GO:0007368	determination of left/right symmetry	0.00774614458474273	0.00774614458474273	+1	NOTCH1,TGFBR2,SOX17,SMAD2
GO:0006302	double-strand break repair	0.007821093001310215	0.007821093001310215	+1	ATM,BRCA1,POLQ,CHEK2,SETD2,BRCA2,RAD21
GO:0007162	negative regulation of cell adhesion	0.008003303596451699	0.008003303596451699	+1	PTEN,CDKN2A,NOTCH1,CDH1,RUNX1,AKT1,CBFB
GO:2001234	negative regulation of apoptotic signaling pathway	0.008050383299312005	0.008050383299312005	+1	NFE2L2,AKT1,AR,HGF,BRCA1,LRRK2
GO:0006334	nucleosome assembly	0.008120336057557733	0.008120336057557733	+1	NPM1,SOX9,ATRX,HIST1H2BD,H3F3C
GO:0046822	regulation of nucleocytoplasmic transport	0.008120336057557733	0.008120336057557733	+1	TP53,PIK3R1,CDH1,SETD2
GO:0090090	negative regulation of canonical Wnt signaling pathway	0.008120336057557733	0.008120336057557733	+1	APC,STK11,SOX9,SOX17,AXIN2
GO:0045619	regulation of lymphocyte differentiation	0.008120336057557733	0.008120336057557733	+1	CDKN2A,GATA3,RUNX1,TGFBR2,CBFB
GO:1903800	positive regulation of production of miRNAs involved in gene silencing by miRNA	0.008190033123453887	0.008190033123453887	+1	TP53,EGFR
GO:0002328	pro-B cell differentiation	0.008190033123453887	0.008190033123453887	+1	NOTCH1,FLT3
GO:1905939	regulation of gonad development	0.008190033123453887	0.008190033123453887	+1	SOX9,WT1
GO:0035520	monoubiquitinated protein deubiquitination	0.008190033123453887	0.008190033123453887	+1	BAP1,ASXL1
GO:0072079	nephron tubule formation	0.008190033123453887	0.008190033123453887	+1	GATA3,SOX9
GO:0048557	embryonic digestive tract morphogenesis	0.008190033123453887	0.008190033123453887	+1	PDGFRA,FGFR2
GO:0046329	negative regulation of JNK cascade	0.008258532981230839	0.008258532981230839	+1	MAPK8IP1,MECOM,NCOR1
GO:0045661	regulation of myoblast differentiation	0.008258532981230839	0.008258532981230839	+1	NOTCH1,TBX3,SOX9
GO:0072171	mesonephric tubule morphogenesis	0.008258532981230839	0.008258532981230839	+1	GATA3,SOX9,WT1
GO:0003197	endocardial cushion development	0.008258532981230839	0.008258532981230839	+1	NOTCH1,SOX9,TGFBR2
GO:0045581	negative regulation of T cell differentiation	0.008258532981230839	0.008258532981230839	+1	CDKN2A,RUNX1,CBFB
GO:0021954	central nervous system neuron development	0.008258532981230839	0.008258532981230839	+1	PTEN,ARHGAP35,FGFR2
GO:1901031	regulation of response to reactive oxygen species	0.008258532981230839	0.008258532981230839	+1	NFE2L2,HGF,LRRK2
GO:0036003	positive regulation of transcription from RNA polymerase II promoter in response to stress	0.008258532981230839	0.008258532981230839	+1	TP53,NOTCH1,NFE2L2
GO:0030509	BMP signaling pathway	0.008307142203987412	0.008307142203987412	+1	NOTCH1,SMAD4,USP9X,ACVR2A,SMAD2
GO:1905269	positive regulation of chromatin organization	0.008407355930946613	0.008407355930946613	+1	CTNNB1,BRCA1,SMAD4,SIN3A
GO:0006475	internal protein amino acid acetylation	0.00860042861438897	0.00860042861438897	+1	BRCA1,EP300,SMAD4,BRCA2,SIN3A
GO:0018394	peptidyl-lysine acetylation	0.008892470591249455	0.008892470591249455	+1	BRCA1,EP300,SMAD4,BRCA2,SIN3A
GO:1902850	microtubule cytoskeleton organization involved in mitosis	0.008892470591249455	0.008892470591249455	+1	STAG2,CHEK2,SETD2,SMC1A,SMC3
GO:0046638	positive regulation of alpha-beta T cell differentiation	0.008922588959325375	0.008922588959325375	+1	RUNX1,TGFBR2,CBFB
GO:0032924	activin receptor signaling pathway	0.008922588959325375	0.008922588959325375	+1	ACVR1B,ACVR2A,SMAD2
GO:0042063	gliogenesis	0.009182607144244275	0.009182607144244275	+1	PTEN,NF1,NOTCH1,SOX9,MIR142
GO:1900180	regulation of protein localization to nucleus	0.009226103321637851	0.009226103321637851	+1	PIK3R1,CDH1,AKT1,SIN3A
GO:0070997	neuron death	0.009548674567263568	0.009548674567263568	+1	NF1,FBXW7,CTNNB1,AKT1,TLR4,LRRK2
GO:2000177	regulation of neural precursor cell proliferation	0.009596591770278107	0.009596591770278107	+1	NF1,CTNNB1,LRRK2
GO:0055010	ventricular cardiac muscle tissue morphogenesis	0.009596591770278107	0.009596591770278107	+1	NOTCH1,FGFR2,SMAD4
GO:0060236	regulation of mitotic spindle organization	0.009596591770278107	0.009596591770278107	+1	STAG2,SMC1A,SMC3
GO:0035850	epithelial cell differentiation involved in kidney development	0.009596591770278107	0.009596591770278107	+1	GATA3,CTNNB1,WT1
GO:0044344	cellular response to fibroblast growth factor stimulus	0.009763599762166977	0.009763599762166977	+1	GATA3,FGFR2,FGFR3,PTPN11,EGR3
GO:0090316	positive regulation of intracellular protein transport	0.009763599762166977	0.009763599762166977	+1	TP53,PIK3R1,FBXW7,CDH1,BAP1
GO:0032070	regulation of deoxyribonuclease activity	0.009777179523681035	0.009777179523681035	+1	NPM1,AKT1
GO:0010452	histone H3-K36 methylation	0.009777179523681035	0.009777179523681035	+1	SETD2,NSD1
GO:1904667	negative regulation of ubiquitin protein ligase activity	0.009777179523681035	0.009777179523681035	+1	CDKN2A,RPL5
GO:0033598	mammary gland epithelial cell proliferation	0.009777179523681035	0.009777179523681035	+1	GATA3,BRCA2
GO:0060911	cardiac cell fate commitment	0.009777179523681035	0.009777179523681035	+1	WT1,SOX17
GO:0048711	positive regulation of astrocyte differentiation	0.009777179523681035	0.009777179523681035	+1	NOTCH1,MIR142
GO:0033147	negative regulation of intracellular estrogen receptor signaling pathway	0.009777179523681035	0.009777179523681035	+1	CRIPAK,BRCA1
GO:0060443	mammary gland morphogenesis	0.009777179523681035	0.009777179523681035	+1	ELF3,FGFR2
GO:0072182	regulation of nephron tubule epithelial cell differentiation	0.009777179523681035	0.009777179523681035	+1	GATA3,CTNNB1
GO:0010823	negative regulation of mitochondrion organization	0.010221437995884559	0.010221437995884559	+1	AKT1,HGF,LRRK2
GO:0046854	phosphatidylinositol phosphorylation	0.010221437995884559	0.010221437995884559	+1	PIK3CA,PIK3R1,PIK3CG
GO:0060043	regulation of cardiac muscle cell proliferation	0.010221437995884559	0.010221437995884559	+1	NOTCH1,ERBB4,FGFR2
GO:0061614	pri-miRNA transcription by RNA polymerase II	0.010221437995884559	0.010221437995884559	+1	TP53,SOX9,WT1
GO:0060021	roof of mouth development	0.010221437995884559	0.010221437995884559	+1	SMAD4,TGFBR2,SMAD2
GO:0032355	response to estradiol	0.010221437995884559	0.010221437995884559	+1	EGFR,CTNNB1,FOXA1
GO:1904706	negative regulation of vascular smooth muscle cell proliferation	0.010221437995884559	0.010221437995884559	+1	PTEN,CDKN1B,CDKN1A
GO:0030278	regulation of ossification	0.010283854229471034	0.010283854229471034	+1	NOTCH1,SOX9,HGF,FGFR2,ACVR2A
GO:0071774	response to fibroblast growth factor	0.010283854229471034	0.010283854229471034	+1	GATA3,FGFR2,FGFR3,PTPN11,EGR3
GO:0009855	determination of bilateral symmetry	0.010369539303256601	0.010369539303256601	+1	NOTCH1,TGFBR2,SOX17,SMAD2
GO:0060964	regulation of gene silencing by miRNA	0.010369539303256601	0.010369539303256601	+1	TP53,EGFR,AJUBA,NCOR1
GO:0002761	regulation of myeloid leukocyte differentiation	0.010369539303256601	0.010369539303256601	+1	FBXW7,RUNX1,MTOR,TLR4
GO:0034330	cell junction organization	0.010477569650916767	0.010477569650916767	+1	PTEN,APC,CTNNB1,CDH1,RUNX1,EPHA3,CBFB
GO:0060560	developmental growth involved in morphogenesis	0.010592871957969515	0.010592871957969515	+1	NOTCH1,CTNNB1,SOX9,FGFR2,USP9X
GO:0009991	response to extracellular stimulus	0.010701996300580588	0.010701996300580588	+1	TP53,ARHGAP35,MTOR,LRRK2,FOXA2,CDKN1A,TAF1
GO:1901888	regulation of cell junction assembly	0.010793133737832847	0.010793133737832847	+1	PTEN,RUNX1,EPHA3,CBFB
GO:0008645	hexose transmembrane transport	0.010793133737832847	0.010793133737832847	+1	PIK3R1,AKT1,BRAF,PTPN11
GO:0045652	regulation of megakaryocyte differentiation	0.010793133737832847	0.010793133737832847	+1	RUNX1,EP300,CBFB,SIN3A
GO:0009799	specification of symmetry	0.010793133737832847	0.010793133737832847	+1	NOTCH1,TGFBR2,SOX17,SMAD2
GO:0003229	ventricular cardiac muscle tissue development	0.01082537556472453	0.01082537556472453	+1	NOTCH1,FGFR2,SMAD4
GO:0008631	intrinsic apoptotic signaling pathway in response to oxidative stress	0.01082537556472453	0.01082537556472453	+1	FBXW7,NFE2L2,AKT1
GO:0038202	TORC1 signaling	0.01082537556472453	0.01082537556472453	+1	STK11,ATM,MTOR
GO:0042692	muscle cell differentiation	0.01082537556472453	0.01082537556472453	+1	NOTCH1,CTNNB1,WT1,KIT,PDGFRA,FGFR2,SMAD4
GO:0035065	regulation of histone acetylation	0.01082537556472453	0.01082537556472453	+1	BRCA1,SMAD4,SIN3A
GO:0010721	negative regulation of cell development	0.01082537556472453	0.01082537556472453	+1	PTEN,NF1,NOTCH1,FBXW7,SOX9,SMAD4
GO:0072091	regulation of stem cell proliferation	0.01082537556472453	0.01082537556472453	+1	NF1,CTNNB1,LRRK2
GO:0072078	nephron tubule morphogenesis	0.01082537556472453	0.01082537556472453	+1	GATA3,SOX9,WT1
GO:0072655	establishment of protein localization to mitochondrion	0.01119897316176173	0.01119897316176173	+1	TP53,FBXW7,BAP1,AKT1,LRRK2
GO:1901989	positive regulation of cell cycle phase transition	0.01121674535398082	0.01121674535398082	+1	RB1,NPM1,CCND1,EZH2
GO:2000136	regulation of cell proliferation involved in heart morphogenesis	0.011430914908685802	0.011430914908685802	+1	NOTCH1,CTNNB1
GO:0035272	exocrine system development	0.011430914908685802	0.011430914908685802	+1	HGF,FGFR2
GO:0007183	SMAD protein complex assembly	0.011430914908685802	0.011430914908685802	+1	SMAD4,SMAD2
GO:0072350	tricarboxylic acid metabolic process	0.011430914908685802	0.011430914908685802	+1	IDH1,IDH2
GO:0060039	pericardium development	0.011430914908685802	0.011430914908685802	+1	NOTCH1,WT1
GO:0030325	adrenal gland development	0.011430914908685802	0.011430914908685802	+1	NF1,WT1
GO:0003401	axis elongation	0.011430914908685802	0.011430914908685802	+1	SOX9,FGFR2
GO:0030889	negative regulation of B cell proliferation	0.011430914908685802	0.011430914908685802	+1	CDKN2A,ATM
GO:1903209	positive regulation of oxidative stress-induced cell death	0.011430914908685802	0.011430914908685802	+1	FBXW7,TLR4
GO:0010826	negative regulation of centrosome duplication	0.011430914908685802	0.011430914908685802	+1	NPM1,BRCA1
GO:0031645	negative regulation of neurological system process	0.011430914908685802	0.011430914908685802	+1	PTEN,LRRK2
GO:2001242	regulation of intrinsic apoptotic signaling pathway	0.011454655076230447	0.011454655076230447	+1	TP53,FBXW7,NFE2L2,AKT1,LRRK2
GO:0046324	regulation of glucose import	0.011503493582657627	0.011503493582657627	+1	PIK3R1,AKT1,PTPN11
GO:0001947	heart looping	0.011503493582657627	0.011503493582657627	+1	NOTCH1,TGFBR2,SOX17
GO:0090224	regulation of spindle organization	0.011503493582657627	0.011503493582657627	+1	STAG2,SMC1A,SMC3
GO:0033048	negative regulation of mitotic sister chromatid segregation	0.011503493582657627	0.011503493582657627	+1	APC,ATM,ATRX
GO:0034219	carbohydrate transmembrane transport	0.011539233873090428	0.011539233873090428	+1	PIK3R1,AKT1,BRAF,PTPN11
GO:0060147	regulation of posttranscriptional gene silencing	0.011539233873090428	0.011539233873090428	+1	TP53,EGFR,AJUBA,NCOR1
GO:0015749	monosaccharide transmembrane transport	0.011539233873090428	0.011539233873090428	+1	PIK3R1,AKT1,BRAF,PTPN11
GO:0060966	regulation of gene silencing by RNA	0.011539233873090428	0.011539233873090428	+1	TP53,EGFR,AJUBA,NCOR1
GO:0006368	transcription elongation from RNA polymerase II promoter	0.012039792873466829	0.012039792873466829	+1	PBRM1,SETD2,CDK12,ERCC2
GO:0000018	regulation of DNA recombination	0.012039792873466829	0.012039792873466829	+1	POLQ,HIST1H1C,SETD2,ERCC2
GO:0070585	protein localization to mitochondrion	0.012090640140897809	0.012090640140897809	+1	TP53,FBXW7,BAP1,AKT1,LRRK2
GO:0009266	response to temperature stimulus	0.012090640140897809	0.012090640140897809	+1	AKT1,ATM,MTOR,EP300,ATR
GO:0072088	nephron epithelium morphogenesis	0.012189848585288668	0.012189848585288668	+1	GATA3,SOX9,WT1
GO:0010863	positive regulation of phospholipase C activity	0.012189848585288668	0.012189848585288668	+1	EGFR,KIT,PDGFRA
GO:0072028	nephron morphogenesis	0.012189848585288668	0.012189848585288668	+1	GATA3,SOX9,WT1
GO:0045670	regulation of osteoclast differentiation	0.012189848585288668	0.012189848585288668	+1	FBXW7,MTOR,TLR4
GO:2000059	negative regulation of ubiquitin-dependent protein catabolic process	0.012189848585288668	0.012189848585288668	+1	CDKN2A,TAF1,RPL5
GO:0061005	cell differentiation involved in kidney development	0.012189848585288668	0.012189848585288668	+1	GATA3,CTNNB1,WT1
GO:0055025	positive regulation of cardiac muscle tissue development	0.012189848585288668	0.012189848585288668	+1	NOTCH1,ERBB4,FGFR2
GO:0046651	lymphocyte proliferation	0.012269742063555468	0.012269742063555468	+1	CDKN2A,FLT3,PIK3CG,ATM,TGFBR2,MAPK8IP1
GO:0042752	regulation of circadian rhythm	0.01246868484364799	0.01246868484364799	+1	TP53,USP9X,SIN3A,EZH2
GO:0032943	mononuclear cell proliferation	0.012893437530714084	0.012893437530714084	+1	CDKN2A,FLT3,PIK3CG,ATM,TGFBR2,MAPK8IP1
GO:0033046	negative regulation of sister chromatid segregation	0.01295936687727957	0.01295936687727957	+1	APC,ATM,ATRX
GO:0060038	cardiac muscle cell proliferation	0.01295936687727957	0.01295936687727957	+1	NOTCH1,ERBB4,FGFR2
GO:0044331	cell-cell adhesion mediated by cadherin	0.01295936687727957	0.01295936687727957	+1	CDH1,FOXA1,FOXA2
GO:0045747	positive regulation of Notch signaling pathway	0.01295936687727957	0.01295936687727957	+1	NOTCH1,ELF3,EP300
GO:0006984	ER-nucleus signaling pathway	0.01295936687727957	0.01295936687727957	+1	TP53,FBXW7,NFE2L2
GO:0045667	regulation of osteoblast differentiation	0.01295936687727957	0.01295936687727957	+1	NOTCH1,HGF,FGFR2,ACVR2A
GO:0061333	renal tubule morphogenesis	0.01295936687727957	0.01295936687727957	+1	GATA3,SOX9,WT1
GO:0045620	negative regulation of lymphocyte differentiation	0.01295936687727957	0.01295936687727957	+1	CDKN2A,RUNX1,CBFB
GO:1903214	regulation of protein targeting to mitochondrion	0.01295936687727957	0.01295936687727957	+1	FBXW7,BAP1,LRRK2
GO:0072160	nephron tubule epithelial cell differentiation	0.0129768017383207	0.0129768017383207	+1	GATA3,CTNNB1
GO:0080182	histone H3-K4 trimethylation	0.0129768017383207	0.0129768017383207	+1	TET2,HIST1H1C
GO:0106030	neuron projection fasciculation	0.0129768017383207	0.0129768017383207	+1	ARHGAP35,EPHA3
GO:0098751	bone cell development	0.0129768017383207	0.0129768017383207	+1	FBXW7,KIT
GO:0007351	tripartite regional subdivision	0.0129768017383207	0.0129768017383207	+1	TBX3,WT1
GO:0007350	blastoderm segmentation	0.0129768017383207	0.0129768017383207	+1	TBX3,WT1
GO:0072224	metanephric glomerulus development	0.0129768017383207	0.0129768017383207	+1	WT1,PDGFRA
GO:0021772	olfactory bulb development	0.0129768017383207	0.0129768017383207	+1	ERBB4,LRRK2
GO:0007413	axonal fasciculation	0.0129768017383207	0.0129768017383207	+1	ARHGAP35,EPHA3
GO:0061323	cell proliferation involved in heart morphogenesis	0.0129768017383207	0.0129768017383207	+1	NOTCH1,CTNNB1
GO:0045686	negative regulation of glial cell differentiation	0.0129768017383207	0.0129768017383207	+1	NF1,NOTCH1
GO:0021988	olfactory lobe development	0.0129768017383207	0.0129768017383207	+1	ERBB4,LRRK2
GO:0070734	histone H3-K27 methylation	0.0129768017383207	0.0129768017383207	+1	HIST1H1C,EZH2
GO:0003198	epithelial to mesenchymal transition involved in endocardial cushion formation	0.0129768017383207	0.0129768017383207	+1	NOTCH1,TGFBR2
GO:0035162	embryonic hemopoiesis	0.0129768017383207	0.0129768017383207	+1	KIT,TGFBR2
GO:0034088	maintenance of mitotic sister chromatid cohesion	0.0129768017383207	0.0129768017383207	+1	RB1,ATRX
GO:0035067	negative regulation of histone acetylation	0.0129768017383207	0.0129768017383207	+1	BRCA1,SIN3A
GO:0033262	regulation of nuclear cell cycle DNA replication	0.0129768017383207	0.0129768017383207	+1	ATRX,CHEK2
GO:0048713	regulation of oligodendrocyte differentiation	0.0129768017383207	0.0129768017383207	+1	NF1,NOTCH1
GO:0050866	negative regulation of cell activation	0.0129768017383207	0.0129768017383207	+1	CDKN2A,RUNX1,ATM,PDGFRA,CBFB
GO:0008595	anterior/posterior axis specification, embryo	0.0129768017383207	0.0129768017383207	+1	TBX3,WT1
GO:0034086	maintenance of sister chromatid cohesion	0.0129768017383207	0.0129768017383207	+1	RB1,ATRX
GO:0045995	regulation of embryonic development	0.013240210317606891	0.013240210317606891	+1	GATA3,CTNNB1,FOXA2,SOX17
GO:0090199	regulation of release of cytochrome c from mitochondria	0.013581067909834413	0.013581067909834413	+1	TP53,AKT1,HGF
GO:2000756	regulation of peptidyl-lysine acetylation	0.013581067909834413	0.013581067909834413	+1	BRCA1,SMAD4,SIN3A
GO:0051985	negative regulation of chromosome segregation	0.013581067909834413	0.013581067909834413	+1	APC,ATM,ATRX
GO:1900274	regulation of phospholipase C activity	0.013581067909834413	0.013581067909834413	+1	EGFR,KIT,PDGFRA
GO:0022408	negative regulation of cell-cell adhesion	0.013610780135652784	0.013610780135652784	+1	CDKN2A,CDH1,RUNX1,AKT1,CBFB
GO:0051147	regulation of muscle cell differentiation	0.013610780135652784	0.013610780135652784	+1	NOTCH1,CTNNB1,KIT,FGFR2,SMAD4
GO:0051099	positive regulation of binding	0.013610780135652784	0.013610780135652784	+1	GATA3,RB1,CTNNB1,LRRK2,TAF1
GO:0034605	cellular response to heat	0.013725187395493312	0.013725187395493312	+1	ATM,MTOR,EP300,ATR
GO:0030900	forebrain development	0.014012938621112001	0.014012938621112001	+1	PTEN,NF1,ERBB4,LRRK2,FGFR2
GO:0045444	fat cell differentiation	0.014012938621112001	0.014012938621112001	+1	GATA3,CEBPA,AKT1,EP300,ASXL1
GO:0006403	RNA localization	0.014114472962984776	0.014114472962984776	+1	NPM1,ATM,U2AF1,SETD2,TGFBR2,ATR
GO:0060079	excitatory postsynaptic potential	0.014400129271672512	0.014400129271672512	+1	PTEN,AKT1,LRRK2
GO:0055021	regulation of cardiac muscle tissue growth	0.014400129271672512	0.014400129271672512	+1	NOTCH1,ERBB4,FGFR2
GO:0061371	determination of heart left/right asymmetry	0.014400129271672512	0.014400129271672512	+1	NOTCH1,TGFBR2,SOX17
GO:0003143	embryonic heart tube morphogenesis	0.014400129271672512	0.014400129271672512	+1	NOTCH1,TGFBR2,SOX17
GO:0008643	carbohydrate transport	0.014797391228918542	0.014797391228918542	+1	PIK3R1,AKT1,BRAF,PTPN11
GO:0071236	cellular response to antibiotic	0.014797391228918542	0.014797391228918542	+1	TP53,NFE2L2,HGF,LRRK2
GO:1905331	negative regulation of morphogenesis of an epithelium	0.01485011667038097	0.01485011667038097	+1	PTEN,GATA3
GO:0060231	mesenchymal to epithelial transition	0.01485011667038097	0.01485011667038097	+1	GATA3,WT1
GO:0072273	metanephric nephron morphogenesis	0.01485011667038097	0.01485011667038097	+1	SOX9,WT1
GO:0046606	negative regulation of centrosome cycle	0.01485011667038097	0.01485011667038097	+1	NPM1,BRCA1
GO:2000757	negative regulation of peptidyl-lysine acetylation	0.01485011667038097	0.01485011667038097	+1	BRCA1,SIN3A
GO:0090185	negative regulation of kidney development	0.01485011667038097	0.01485011667038097	+1	GATA3,WT1
GO:0002320	lymphoid progenitor cell differentiation	0.01485011667038097	0.01485011667038097	+1	NOTCH1,FLT3
GO:1900409	positive regulation of cellular response to oxidative stress	0.01485011667038097	0.01485011667038097	+1	FBXW7,TLR4
GO:0048385	regulation of retinoic acid receptor signaling pathway	0.01485011667038097	0.01485011667038097	+1	ASXL1,EZH2
GO:2000696	regulation of epithelial cell differentiation involved in kidney development	0.01485011667038097	0.01485011667038097	+1	GATA3,CTNNB1
GO:0043030	regulation of macrophage activation	0.015168895725861201	0.015168895725861201	+1	CEBPA,TLR4,MIR142
GO:0046323	glucose import	0.015168895725861201	0.015168895725861201	+1	PIK3R1,AKT1,PTPN11
GO:0030178	negative regulation of Wnt signaling pathway	0.015536398948328716	0.015536398948328716	+1	APC,STK11,SOX9,SOX17,AXIN2
GO:0046824	positive regulation of nucleocytoplasmic transport	0.01613491540818527	0.01613491540818527	+1	TP53,PIK3R1,CDH1
GO:0032873	negative regulation of stress-activated MAPK cascade	0.01613491540818527	0.01613491540818527	+1	MAPK8IP1,MECOM,NCOR1
GO:0070303	negative regulation of stress-activated protein kinase signaling cascade	0.01613491540818527	0.01613491540818527	+1	MAPK8IP1,MECOM,NCOR1
GO:2000241	regulation of reproductive process	0.01643108689762412	0.01643108689762412	+1	SOX9,WT1,FGFR2,ACVR1B
GO:0016202	regulation of striated muscle tissue development	0.01643108689762412	0.01643108689762412	+1	NOTCH1,ERBB4,FGFR2,SMAD4
GO:2001022	positive regulation of response to DNA damage stimulus	0.01643108689762412	0.01643108689762412	+1	EGFR,ATM,BRCA1,ATR
GO:0014706	striated muscle tissue development	0.016680323224828944	0.016680323224828944	+1	NOTCH1,WT1,ERBB4,PDGFRA,FGFR2,SMAD4
GO:0106106	cold-induced thermogenesis	0.016797507799976717	0.016797507799976717	+1	APC,RB1,NOTCH1,STK11,TLR4
GO:0033260	nuclear DNA replication	0.016797507799976717	0.016797507799976717	+1	ATRX,CHEK2,BRCA2
GO:0006103	2-oxoglutarate metabolic process	0.016797507799976717	0.016797507799976717	+1	IDH1,IDH2
GO:1901861	regulation of muscle tissue development	0.016797507799976717	0.016797507799976717	+1	NOTCH1,ERBB4,FGFR2,SMAD4
GO:0009952	anterior/posterior pattern specification	0.016797507799976717	0.016797507799976717	+1	TBX3,WT1,FOXA2,SMAD2
GO:0072425	signal transduction involved in G2 DNA damage checkpoint	0.016797507799976717	0.016797507799976717	+1	ATM,BRCA1
GO:0000070	mitotic sister chromatid segregation	0.016797507799976717	0.016797507799976717	+1	APC,RB1,ATM,ATRX,SMC1A
GO:0071300	cellular response to retinoic acid	0.016797507799976717	0.016797507799976717	+1	EPHA3,SOX9,ATM
GO:2000047	regulation of cell-cell adhesion mediated by cadherin	0.016797507799976717	0.016797507799976717	+1	FOXA1,FOXA2
GO:0046635	positive regulation of alpha-beta T cell activation	0.016797507799976717	0.016797507799976717	+1	RUNX1,TGFBR2,CBFB
GO:0120161	regulation of cold-induced thermogenesis	0.016797507799976717	0.016797507799976717	+1	APC,RB1,NOTCH1,STK11,TLR4
GO:0007530	sex determination	0.016797507799976717	0.016797507799976717	+1	SOX9,WT1
GO:0006978	DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator	0.016797507799976717	0.016797507799976717	+1	TP53,BRCA1
GO:2000191	regulation of fatty acid transport	0.016797507799976717	0.016797507799976717	+1	AKT1,NCOR1
GO:0072111	cell proliferation involved in kidney development	0.016797507799976717	0.016797507799976717	+1	GATA3,WT1
GO:0035313	wound healing, spreading of epidermal cells	0.016797507799976717	0.016797507799976717	+1	PTEN,MTOR
GO:0010224	response to UV-B	0.016797507799976717	0.016797507799976717	+1	STK11,CDKN1A
GO:0072207	metanephric epithelium development	0.016797507799976717	0.016797507799976717	+1	SOX9,WT1
GO:0038092	nodal signaling pathway	0.016797507799976717	0.016797507799976717	+1	ACVR1B,SMAD2
GO:0043388	positive regulation of DNA binding	0.016797507799976717	0.016797507799976717	+1	GATA3,RB1,CTNNB1
GO:0043517	positive regulation of DNA damage response, signal transduction by p53 class mediator	0.016797507799976717	0.016797507799976717	+1	ATM,ATR
GO:0021537	telencephalon development	0.017427877390517085	0.017427877390517085	+1	PTEN,NF1,ERBB4,LRRK2
GO:0006354	DNA-templated transcription, elongation	0.017427877390517085	0.017427877390517085	+1	PBRM1,SETD2,CDK12,ERCC2
GO:0046834	lipid phosphorylation	0.01782613973858692	0.01782613973858692	+1	PIK3CA,PIK3R1,PIK3CG
GO:0060759	regulation of response to cytokine stimulus	0.01803000164380191	0.01803000164380191	+1	RUNX1,TLR4,CBFB,PTPN11,LIFR
GO:0048639	positive regulation of developmental growth	0.018078423544770513	0.018078423544770513	+1	NOTCH1,WT1,ERBB4,FGFR2
GO:0010038	response to metal ion	0.01834374808764433	0.01834374808764433	+1	EGFR,CDH1,AKT1,BRAF,CDKN1B,LRRK2
GO:1990845	adaptive thermogenesis	0.01849712413686661	0.01849712413686661	+1	APC,RB1,NOTCH1,STK11,TLR4
GO:2000278	regulation of DNA biosynthetic process	0.018714728981560666	0.018714728981560666	+1	TP53,ATM,HGF,ATR
GO:0046631	alpha-beta T cell activation	0.018714728981560666	0.018714728981560666	+1	RUNX1,TGFBR2,CBFB,MAPK8IP1
GO:0045839	negative regulation of mitotic nuclear division	0.018728413746902352	0.018728413746902352	+1	APC,ATM,ATRX
GO:0070830	bicellular tight junction assembly	0.018728413746902352	0.018728413746902352	+1	APC,RUNX1,CBFB
GO:0120192	tight junction assembly	0.018728413746902352	0.018728413746902352	+1	APC,RUNX1,CBFB
GO:0046637	regulation of alpha-beta T cell differentiation	0.018728413746902352	0.018728413746902352	+1	RUNX1,TGFBR2,CBFB
GO:2000243	positive regulation of reproductive process	0.018728413746902352	0.018728413746902352	+1	SOX9,WT1,ACVR1B
GO:0035050	embryonic heart tube development	0.018728413746902352	0.018728413746902352	+1	NOTCH1,TGFBR2,SOX17
GO:0030071	regulation of mitotic metaphase/anaphase transition	0.018728413746902352	0.018728413746902352	+1	APC,RB1,ATM
GO:0007252	I-kappaB phosphorylation	0.018783121962783634	0.018783121962783634	+1	AKT1,TLR4
GO:0090201	negative regulation of release of cytochrome c from mitochondria	0.018783121962783634	0.018783121962783634	+1	AKT1,HGF
GO:0016584	nucleosome positioning	0.018783121962783634	0.018783121962783634	+1	CTCF,HIST1H1C
GO:0051570	regulation of histone H3-K9 methylation	0.018783121962783634	0.018783121962783634	+1	ATRX,BRCA1
GO:0042772	DNA damage response, signal transduction resulting in transcription	0.018783121962783634	0.018783121962783634	+1	TP53,BRCA1
GO:0035635	entry of bacterium into host cell	0.018783121962783634	0.018783121962783634	+1	CTNNB1,CDH1
GO:0045992	negative regulation of embryonic development	0.018783121962783634	0.018783121962783634	+1	GATA3,CTNNB1
GO:0048103	somatic stem cell division	0.018783121962783634	0.018783121962783634	+1	CDKN2A,FGFR2
GO:1902884	positive regulation of response to oxidative stress	0.018783121962783634	0.018783121962783634	+1	FBXW7,TLR4
GO:0036475	neuron death in response to oxidative stress	0.018783121962783634	0.018783121962783634	+1	FBXW7,TLR4
GO:0071850	mitotic cell cycle arrest	0.018783121962783634	0.018783121962783634	+1	CDKN1B,CDKN1A
GO:0043371	negative regulation of CD4-positive, alpha-beta T cell differentiation	0.018783121962783634	0.018783121962783634	+1	RUNX1,CBFB
GO:1903203	regulation of oxidative stress-induced neuron death	0.018783121962783634	0.018783121962783634	+1	FBXW7,TLR4
GO:0048634	regulation of muscle organ development	0.01911145296551228	0.01911145296551228	+1	NOTCH1,ERBB4,FGFR2,SMAD4
GO:1902107	positive regulation of leukocyte differentiation	0.01911145296551228	0.01911145296551228	+1	GATA3,RUNX1,TGFBR2,CBFB
GO:0003002	regionalization	0.019186058010574786	0.019186058010574786	+1	TBX3,WT1,FGFR2,FOXA2,SMAD2
GO:0001649	osteoblast differentiation	0.019186058010574786	0.019186058010574786	+1	NF1,NOTCH1,HGF,FGFR2,ACVR2A
GO:0099565	chemical synaptic transmission, postsynaptic	0.01953071576117636	0.01953071576117636	+1	PTEN,AKT1,LRRK2
GO:1905268	negative regulation of chromatin organization	0.01953071576117636	0.01953071576117636	+1	BRCA1,HIST1H1C,SIN3A
GO:2000514	regulation of CD4-positive, alpha-beta T cell activation	0.01953071576117636	0.01953071576117636	+1	RUNX1,TGFBR2,CBFB
GO:1902099	regulation of metaphase/anaphase transition of cell cycle	0.01953071576117636	0.01953071576117636	+1	APC,RB1,ATM
GO:0014855	striated muscle cell proliferation	0.01953071576117636	0.01953071576117636	+1	NOTCH1,ERBB4,FGFR2
GO:0043433	negative regulation of DNA-binding transcription factor activity	0.02016285227698739	0.02016285227698739	+1	CDKN2A,RB1,KEAP1,FOXA2,TAF1
GO:0001952	regulation of cell-matrix adhesion	0.020388479360482256	0.020388479360482256	+1	PTEN,NF1,CDKN2A,EPHA3
GO:0031398	positive regulation of protein ubiquitination	0.020388479360482256	0.020388479360482256	+1	PTEN,FBXW7,BRCA1,LRRK2
GO:1903038	negative regulation of leukocyte cell-cell adhesion	0.020388479360482256	0.020388479360482256	+1	CDKN2A,RUNX1,AKT1,CBFB
GO:0120193	tight junction organization	0.020484012458863835	0.020484012458863835	+1	APC,RUNX1,CBFB
GO:0021782	glial cell development	0.020484012458863835	0.020484012458863835	+1	PTEN,NF1,MIR142
GO:0032206	positive regulation of telomere maintenance	0.020484012458863835	0.020484012458863835	+1	ATM,ATRX,ATR
GO:0035108	limb morphogenesis	0.020484012458863835	0.020484012458863835	+1	CTNNB1,TBX3,FGFR2
GO:0035107	appendage morphogenesis	0.020484012458863835	0.020484012458863835	+1	CTNNB1,TBX3,FGFR2
GO:0046890	regulation of lipid biosynthetic process	0.020553625820090383	0.020553625820090383	+1	FBXW7,IDH1,AKT1,MTOR,BRCA1
GO:0071425	hematopoietic stem cell proliferation	0.020781856934817287	0.020781856934817287	+1	RUNX1,MECOM
GO:0051444	negative regulation of ubiquitin-protein transferase activity	0.020781856934817287	0.020781856934817287	+1	CDKN2A,RPL5
GO:0072012	glomerulus vasculature development	0.020781856934817287	0.020781856934817287	+1	WT1,PDGFRA
GO:0048854	brain morphogenesis	0.020781856934817287	0.020781856934817287	+1	PTEN,NF1
GO:0003338	metanephros morphogenesis	0.020781856934817287	0.020781856934817287	+1	SOX9,WT1
GO:0001569	branching involved in blood vessel morphogenesis	0.020781856934817287	0.020781856934817287	+1	CTNNB1,TGFBR2
GO:2000678	negative regulation of transcription regulatory region DNA binding	0.020781856934817287	0.020781856934817287	+1	TAF1,SIN3A
GO:0010165	response to X-ray	0.020781856934817287	0.020781856934817287	+1	GATA3,ATM
GO:2000811	negative regulation of anoikis	0.020781856934817287	0.020781856934817287	+1	PIK3CA,NOTCH1
GO:0045116	protein neddylation	0.020781856934817287	0.020781856934817287	+1	CDKN2A,RPL5
GO:0046426	negative regulation of receptor signaling pathway via JAK-STAT	0.020781856934817287	0.020781856934817287	+1	VHL,PPP2R1A
GO:0070102	interleukin-6-mediated signaling pathway	0.020781856934817287	0.020781856934817287	+1	SMAD4,PTPN11
GO:0045687	positive regulation of glial cell differentiation	0.020781856934817287	0.020781856934817287	+1	NOTCH1,MIR142
GO:0051250	negative regulation of lymphocyte activation	0.02080092721840656	0.02080092721840656	+1	CDKN2A,RUNX1,ATM,CBFB
GO:0007051	spindle organization	0.020870498271713597	0.020870498271713597	+1	STAG2,CHEK2,SMC1A,SMC3,NCOR1
GO:0006473	protein acetylation	0.020870498271713597	0.020870498271713597	+1	BRCA1,EP300,SMAD4,BRCA2,SIN3A
GO:0007091	metaphase/anaphase transition of mitotic cell cycle	0.02137790582033313	0.02137790582033313	+1	APC,RB1,ATM
GO:0032869	cellular response to insulin stimulus	0.021411822811718544	0.021411822811718544	+1	PIK3CA,APC,PIK3R1,AKT1,PTPN11
GO:0007517	muscle organ development	0.021844201005189523	0.021844201005189523	+1	NOTCH1,WT1,ERBB4,FGFR2,SMAD4,EGR3
GO:1901675	negative regulation of histone H3-K27 acetylation	0.021844201005189523	0.021844201005189523	+1	SIN3A
GO:1900259	regulation of RNA-directed 5'-3' RNA polymerase activity	0.021844201005189523	0.021844201005189523	+1	EIF4A2
GO:1902629	regulation of mRNA stability involved in cellular response to UV	0.021844201005189523	0.021844201005189523	+1	NPM1
GO:1903125	negative regulation of thioredoxin peroxidase activity by peptidyl-threonine phosphorylation	0.021844201005189523	0.021844201005189523	+1	LRRK2
GO:1903217	negative regulation of protein processing involved in protein targeting to mitochondrion	0.021844201005189523	0.021844201005189523	+1	LRRK2
GO:1903216	regulation of protein processing involved in protein targeting to mitochondrion	0.021844201005189523	0.021844201005189523	+1	LRRK2
GO:1901984	negative regulation of protein acetylation	0.021844201005189523	0.021844201005189523	+1	BRCA1,SIN3A
GO:1901580	regulation of telomeric RNA transcription from RNA pol II promoter	0.021844201005189523	0.021844201005189523	+1	ATRX
GO:1903124	negative regulation of thioredoxin peroxidase activity	0.021844201005189523	0.021844201005189523	+1	LRRK2
GO:1902298	cell cycle DNA replication maintenance of fidelity	0.021844201005189523	0.021844201005189523	+1	BRCA2
GO:1903123	regulation of thioredoxin peroxidase activity	0.021844201005189523	0.021844201005189523	+1	LRRK2
GO:1900260	negative regulation of RNA-directed 5'-3' RNA polymerase activity	0.021844201005189523	0.021844201005189523	+1	EIF4A2
GO:1902178	fibroblast growth factor receptor apoptotic signaling pathway	0.021844201005189523	0.021844201005189523	+1	FGFR3
GO:1904262	negative regulation of TORC1 signaling	0.021844201005189523	0.021844201005189523	+1	STK11,ATM
GO:1901582	positive regulation of telomeric RNA transcription from RNA pol II promoter	0.021844201005189523	0.021844201005189523	+1	ATRX
GO:1901581	negative regulation of telomeric RNA transcription from RNA pol II promoter	0.021844201005189523	0.021844201005189523	+1	ATRX
GO:0060527	prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis	0.021844201005189523	0.021844201005189523	+1	FGFR2
GO:0140067	peptidyl-lysine butyrylation	0.021844201005189523	0.021844201005189523	+1	EP300
GO:0060517	epithelial cell proliferation involved in prostatic bud elongation	0.021844201005189523	0.021844201005189523	+1	SOX9
GO:0060523	prostate epithelial cord elongation	0.021844201005189523	0.021844201005189523	+1	FGFR2
GO:0060525	prostate glandular acinus development	0.021844201005189523	0.021844201005189523	+1	FGFR2
GO:0060526	prostate glandular acinus morphogenesis	0.021844201005189523	0.021844201005189523	+1	FGFR2
GO:0060529	squamous basal epithelial stem cell differentiation involved in prostate gland acinus development	0.021844201005189523	0.021844201005189523	+1	FGFR2
GO:0060615	mammary gland bud formation	0.021844201005189523	0.021844201005189523	+1	FGFR2
GO:0060638	mesenchymal-epithelial cell signaling	0.021844201005189523	0.021844201005189523	+1	HGF
GO:0060648	mammary gland bud morphogenesis	0.021844201005189523	0.021844201005189523	+1	FGFR2
GO:0060665	regulation of branching involved in salivary gland morphogenesis by mesenchymal-epithelial signaling	0.021844201005189523	0.021844201005189523	+1	HGF
GO:0060667	branch elongation involved in salivary gland morphogenesis	0.021844201005189523	0.021844201005189523	+1	FGFR2
GO:0060670	branching involved in labyrinthine layer morphogenesis	0.021844201005189523	0.021844201005189523	+1	FGFR2
GO:0060687	regulation of branching involved in prostate gland morphogenesis	0.021844201005189523	0.021844201005189523	+1	FGFR2
GO:0060735	regulation of eIF2 alpha phosphorylation by dsRNA	0.021844201005189523	0.021844201005189523	+1	NPM1
GO:0060784	regulation of cell proliferation involved in tissue homeostasis	0.021844201005189523	0.021844201005189523	+1	SOX9
GO:0060796	regulation of transcription involved in primary germ layer cell fate commitment	0.021844201005189523	0.021844201005189523	+1	SOX17
GO:0060807	regulation of transcription from RNA polymerase II promoter involved in definitive endodermal cell fate specification	0.021844201005189523	0.021844201005189523	+1	SOX17
GO:0060843	venous endothelial cell differentiation	0.021844201005189523	0.021844201005189523	+1	NOTCH1
GO:0060915	mesenchymal cell differentiation involved in lung development	0.021844201005189523	0.021844201005189523	+1	FGFR2
GO:0060995	cell-cell signaling involved in kidney development	0.021844201005189523	0.021844201005189523	+1	GATA3
GO:2000971	negative regulation of detection of glucose	0.021844201005189523	0.021844201005189523	+1	FOXA2
GO:1904887	Wnt signalosome assembly	0.021844201005189523	0.021844201005189523	+1	LRRK2
GO:0061032	visceral serous pericardium development	0.021844201005189523	0.021844201005189523	+1	WT1
GO:2000808	negative regulation of synaptic vesicle clustering	0.021844201005189523	0.021844201005189523	+1	PTEN
GO:0060516	primary prostatic bud elongation	0.021844201005189523	0.021844201005189523	+1	SOX9
GO:0060463	lung lobe morphogenesis	0.021844201005189523	0.021844201005189523	+1	FGFR2
GO:0060462	lung lobe development	0.021844201005189523	0.021844201005189523	+1	FGFR2
GO:0060449	bud elongation involved in lung branching	0.021844201005189523	0.021844201005189523	+1	FGFR2
GO:0002649	regulation of tolerance induction to self antigen	0.021844201005189523	0.021844201005189523	+1	TGFBR2
GO:0040030	regulation of molecular function, epigenetic	0.021844201005189523	0.021844201005189523	+1	CTCF
GO:0002651	positive regulation of tolerance induction to self antigen	0.021844201005189523	0.021844201005189523	+1	TGFBR2
GO:0043969	histone H2B acetylation	0.021844201005189523	0.021844201005189523	+1	EP300
GO:0044336	canonical Wnt signaling pathway involved in negative regulation of apoptotic process	0.021844201005189523	0.021844201005189523	+1	CTNNB1
GO:0044784	metaphase/anaphase transition of cell cycle	0.021844201005189523	0.021844201005189523	+1	APC,RB1,ATM
GO:0035607	fibroblast growth factor receptor signaling pathway involved in orbitofrontal cortex development	0.021844201005189523	0.021844201005189523	+1	FGFR2
GO:0035604	fibroblast growth factor receptor signaling pathway involved in positive regulation of cell proliferation in bone marrow	0.021844201005189523	0.021844201005189523	+1	FGFR2
GO:0035603	fibroblast growth factor receptor signaling pathway involved in hemopoiesis	0.021844201005189523	0.021844201005189523	+1	FGFR2
GO:0035602	fibroblast growth factor receptor signaling pathway involved in negative regulation of apoptotic process in bone marrow cell	0.021844201005189523	0.021844201005189523	+1	FGFR2
GO:0061289	Wnt signaling pathway involved in kidney development	0.021844201005189523	0.021844201005189523	+1	GATA3
GO:0003142	cardiogenic plate morphogenesis	0.021844201005189523	0.021844201005189523	+1	SOX17
GO:0045951	positive regulation of mitotic recombination	0.021844201005189523	0.021844201005189523	+1	ERCC2
GO:0046328	regulation of JNK cascade	0.021844201005189523	0.021844201005189523	+1	EGFR,MAP2K4,MAPK8IP1,MECOM,NCOR1
GO:0003181	atrioventricular valve morphogenesis	0.021844201005189523	0.021844201005189523	+1	NOTCH1,TGFBR2
GO:0003213	cardiac right atrium morphogenesis	0.021844201005189523	0.021844201005189523	+1	NOTCH1
GO:0003415	chondrocyte hypertrophy	0.021844201005189523	0.021844201005189523	+1	SOX9
GO:0006305	DNA alkylation	0.021844201005189523	0.021844201005189523	+1	DNMT3A,WT1,ATRX
GO:0006306	DNA methylation	0.021844201005189523	0.021844201005189523	+1	DNMT3A,WT1,ATRX
GO:0032275	luteinizing hormone secretion	0.021844201005189523	0.021844201005189523	+1	TBX3
GO:0051138	positive regulation of NK T cell differentiation	0.021844201005189523	0.021844201005189523	+1	TGFBR2
GO:0055008	cardiac muscle tissue morphogenesis	0.021844201005189523	0.021844201005189523	+1	NOTCH1,FGFR2,SMAD4
GO:0060261	positive regulation of transcription initiation from RNA polymerase II promoter	0.021844201005189523	0.021844201005189523	+1	TP53,TAF1
GO:0045861	negative regulation of proteolysis	0.021844201005189523	0.021844201005189523	+1	CDKN2A,AKT1,HGF,LRRK2,TAF1,RPL5
GO:0061290	canonical Wnt signaling pathway involved in metanephric kidney development	0.021844201005189523	0.021844201005189523	+1	GATA3
GO:2000970	regulation of detection of glucose	0.021844201005189523	0.021844201005189523	+1	FOXA2
GO:0061437	renal system vasculature development	0.021844201005189523	0.021844201005189523	+1	WT1,PDGFRA
GO:0072302	negative regulation of metanephric glomerular mesangial cell proliferation	0.021844201005189523	0.021844201005189523	+1	WT1
GO:0072362	regulation of glycolytic process by negative regulation of transcription from RNA polymerase II promoter	0.021844201005189523	0.021844201005189523	+1	NCOR1
GO:0010965	regulation of mitotic sister chromatid separation	0.021844201005189523	0.021844201005189523	+1	APC,RB1,ATM
GO:0072428	signal transduction involved in intra-S DNA damage checkpoint	0.021844201005189523	0.021844201005189523	+1	CHEK2
GO:1990505	mitotic DNA replication maintenance of fidelity	0.021844201005189523	0.021844201005189523	+1	BRCA2
GO:0072659	protein localization to plasma membrane	0.021844201005189523	0.021844201005189523	+1	EGFR,PIK3R1,CDH1,EPHA3,AKT1,AR
GO:1990426	mitotic recombination-dependent replication fork processing	0.021844201005189523	0.021844201005189523	+1	BRCA2
GO:0001836	release of cytochrome c from mitochondria	0.021844201005189523	0.021844201005189523	+1	TP53,AKT1,HGF
GO:0010810	regulation of cell-substrate adhesion	0.021844201005189523	0.021844201005189523	+1	PTEN,NF1,CDKN2A,NOTCH1,EPHA3
GO:1905929	positive regulation of invadopodium disassembly	0.021844201005189523	0.021844201005189523	+1	NAV3
GO:1905927	regulation of invadopodium disassembly	0.021844201005189523	0.021844201005189523	+1	NAV3
GO:0061324	canonical Wnt signaling pathway involved in positive regulation of cardiac outflow tract cell proliferation	0.021844201005189523	0.021844201005189523	+1	CTNNB1
GO:1905878	invadopodium disassembly	0.021844201005189523	0.021844201005189523	+1	NAV3
GO:0097326	melanocyte adhesion	0.021844201005189523	0.021844201005189523	+1	KIT
GO:0097393	telomeric repeat-containing RNA transcription	0.021844201005189523	0.021844201005189523	+1	ATRX
GO:0097394	telomeric repeat-containing RNA transcription by RNA polymerase II	0.021844201005189523	0.021844201005189523	+1	ATRX
GO:0001659	temperature homeostasis	0.021844201005189523	0.021844201005189523	+1	APC,RB1,NOTCH1,STK11,TLR4
GO:1905317	inferior endocardial cushion morphogenesis	0.021844201005189523	0.021844201005189523	+1	TGFBR2
GO:1905305	negative regulation of cardiac myofibril assembly	0.021844201005189523	0.021844201005189523	+1	SMAD4
GO:1905304	regulation of cardiac myofibril assembly	0.021844201005189523	0.021844201005189523	+1	SMAD4
GO:1905277	negative regulation of epithelial tube formation	0.021844201005189523	0.021844201005189523	+1	GATA3
GO:1905208	negative regulation of cardiocyte differentiation	0.021844201005189523	0.021844201005189523	+1	EGFR,SMAD4
GO:1904893	negative regulation of receptor signaling pathway via STAT	0.021844201005189523	0.021844201005189523	+1	VHL,PPP2R1A
GO:0100002	negative regulation of protein kinase activity by protein phosphorylation	0.021844201005189523	0.021844201005189523	+1	AKT1
GO:0097306	cellular response to alcohol	0.021844201005189523	0.021844201005189523	+1	CTNNB1,CDH1,BRCA1
GO:0072299	negative regulation of metanephric glomerulus development	0.021844201005189523	0.021844201005189523	+1	WT1
GO:0007542	primary sex determination, germ-line	0.021844201005189523	0.021844201005189523	+1	SOX9
GO:0072204	cell-cell signaling involved in metanephros development	0.021844201005189523	0.021844201005189523	+1	GATA3
GO:0061440	kidney vasculature development	0.021844201005189523	0.021844201005189523	+1	WT1,PDGFRA
GO:0061921	peptidyl-lysine propionylation	0.021844201005189523	0.021844201005189523	+1	EP300
GO:0061986	negative regulation of transcription by glucose	0.021844201005189523	0.021844201005189523	+1	FOXA2
GO:0061987	negative regulation of transcription from RNA polymerase II promoter by glucose	0.021844201005189523	0.021844201005189523	+1	FOXA2
GO:2000734	negative regulation of glial cell-derived neurotrophic factor receptor signaling pathway involved in ureteric bud formation	0.021844201005189523	0.021844201005189523	+1	GATA3
GO:2000733	regulation of glial cell-derived neurotrophic factor receptor signaling pathway involved in ureteric bud formation	0.021844201005189523	0.021844201005189523	+1	GATA3
GO:2000703	negative regulation of fibroblast growth factor receptor signaling pathway involved in ureteric bud formation	0.021844201005189523	0.021844201005189523	+1	GATA3
GO:2000702	regulation of fibroblast growth factor receptor signaling pathway involved in ureteric bud formation	0.021844201005189523	0.021844201005189523	+1	GATA3
GO:2000701	glial cell-derived neurotrophic factor receptor signaling pathway involved in ureteric bud formation	0.021844201005189523	0.021844201005189523	+1	GATA3
GO:2000699	fibroblast growth factor receptor signaling pathway involved in ureteric bud formation	0.021844201005189523	0.021844201005189523	+1	GATA3
GO:0070373	negative regulation of ERK1 and ERK2 cascade	0.021844201005189523	0.021844201005189523	+1	PTEN,TLR4,SMAD4
GO:0070413	trehalose metabolism in response to stress	0.021844201005189523	0.021844201005189523	+1	BRAF
GO:0001101	response to acid chemical	0.021844201005189523	0.021844201005189523	+1	EPHA3,SOX9,ATM,MTOR,ASXL1
GO:0070512	positive regulation of histone H4-K20 methylation	0.021844201005189523	0.021844201005189523	+1	BRCA1
GO:0021897	forebrain astrocyte development	0.021844201005189523	0.021844201005189523	+1	NF1
GO:0070510	regulation of histone H4-K20 methylation	0.021844201005189523	0.021844201005189523	+1	BRCA1
GO:2000607	negative regulation of cell proliferation involved in mesonephros development	0.021844201005189523	0.021844201005189523	+1	GATA3
GO:0072175	epithelial tube formation	0.021844201005189523	0.021844201005189523	+1	GATA3,SOX9,FGFR2
GO:0016046	detection of fungus	0.021844201005189523	0.021844201005189523	+1	TLR4
GO:0021896	forebrain astrocyte differentiation	0.021844201005189523	0.021844201005189523	+1	NF1
GO:0018992	germ-line sex determination	0.021844201005189523	0.021844201005189523	+1	SOX9
GO:0007221	positive regulation of transcription of Notch receptor target	0.021844201005189523	0.021844201005189523	+1	NOTCH1,EP300
GO:0019100	male germ-line sex determination	0.021844201005189523	0.021844201005189523	+1	SOX9
GO:0021769	orbitofrontal cortex development	0.021844201005189523	0.021844201005189523	+1	FGFR2
GO:2000469	negative regulation of peroxidase activity	0.021844201005189523	0.021844201005189523	+1	LRRK2
GO:2000606	regulation of cell proliferation involved in mesonephros development	0.021844201005189523	0.021844201005189523	+1	GATA3
GO:0051784	negative regulation of nuclear division	0.022854336959796145	0.022854336959796145	+1	APC,ATM,ATRX
GO:0055017	cardiac muscle tissue growth	0.022854336959796145	0.022854336959796145	+1	NOTCH1,ERBB4,FGFR2
GO:1900182	positive regulation of protein localization to nucleus	0.022854336959796145	0.022854336959796145	+1	PIK3R1,CDH1,AKT1
GO:0042177	negative regulation of protein catabolic process	0.023291719169523863	0.023291719169523863	+1	EGFR,CDKN2A,TAF1,RPL5
GO:0048512	circadian behavior	0.023596851765751024	0.023596851765751024	+1	TP53,PTEN
GO:0033233	regulation of protein sumoylation	0.023596851765751024	0.023596851765751024	+1	CDKN2A,CTNNB1
GO:0030851	granulocyte differentiation	0.023596851765751024	0.023596851765751024	+1	RUNX1,CEBPA
GO:1902176	negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway	0.023596851765751024	0.023596851765751024	+1	NFE2L2,AKT1
GO:0045671	negative regulation of osteoclast differentiation	0.023596851765751024	0.023596851765751024	+1	FBXW7,TLR4
GO:0030277	maintenance of gastrointestinal epithelium	0.023596851765751024	0.023596851765751024	+1	SOX9,TLR4
GO:0007622	rhythmic behavior	0.023596851765751024	0.023596851765751024	+1	TP53,PTEN
GO:0021879	forebrain neuron differentiation	0.023596851765751024	0.023596851765751024	+1	ERBB4,FGFR2
GO:0035315	hair cell differentiation	0.023596851765751024	0.023596851765751024	+1	CTNNB1,ERCC2
GO:0021955	central nervous system neuron axonogenesis	0.023596851765751024	0.023596851765751024	+1	PTEN,ARHGAP35
GO:0016331	morphogenesis of embryonic epithelium	0.023687756952379107	0.023687756952379107	+1	GATA3,SOX9,FGFR2
GO:0048839	inner ear development	0.023687756952379107	0.023687756952379107	+1	SOX9,FGFR2,PTPN11
GO:0003158	endothelium development	0.023687756952379107	0.023687756952379107	+1	NOTCH1,CTNNB1,SOX17,VEZF1
GO:0046605	regulation of centrosome cycle	0.023687756952379107	0.023687756952379107	+1	CTNNB1,NPM1,BRCA1
GO:0048662	negative regulation of smooth muscle cell proliferation	0.023687756952379107	0.023687756952379107	+1	PTEN,CDKN1B,CDKN1A
GO:0043967	histone H4 acetylation	0.023687756952379107	0.023687756952379107	+1	BRCA1,EP300,BRCA2
GO:0051145	smooth muscle cell differentiation	0.023687756952379107	0.023687756952379107	+1	NOTCH1,KIT,FGFR2
GO:0014013	regulation of gliogenesis	0.023687756952379107	0.023687756952379107	+1	NF1,NOTCH1,MIR142
GO:0008543	fibroblast growth factor receptor signaling pathway	0.023687756952379107	0.023687756952379107	+1	GATA3,FGFR2,FGFR3,PTPN11
GO:0043297	apical junction assembly	0.023687756952379107	0.023687756952379107	+1	APC,RUNX1,CBFB
GO:0051306	mitotic sister chromatid separation	0.023687756952379107	0.023687756952379107	+1	APC,RB1,ATM
GO:0007610	behavior	0.023687756952379107	0.023687756952379107	+1	TP53,PTEN,EGFR,NF1,LRRK2,FOXA2
GO:0007052	mitotic spindle organization	0.023687756952379107	0.023687756952379107	+1	STAG2,CHEK2,SMC1A,SMC3
GO:0031667	response to nutrient levels	0.024107769967603516	0.024107769967603516	+1	TP53,MTOR,LRRK2,FOXA2,CDKN1A,TAF1
GO:0051053	negative regulation of DNA metabolic process	0.024424465932079434	0.024424465932079434	+1	TP53,ATM,POLQ,HIST1H1C
GO:0032868	response to insulin	0.024688123381725793	0.024688123381725793	+1	PIK3CA,APC,PIK3R1,AKT1,PTPN11
GO:0032388	positive regulation of intracellular transport	0.024688123381725793	0.024688123381725793	+1	TP53,PIK3R1,FBXW7,CDH1,BAP1
GO:0048636	positive regulation of muscle organ development	0.024688123381725793	0.024688123381725793	+1	NOTCH1,ERBB4,FGFR2
GO:0072332	intrinsic apoptotic signaling pathway by p53 class mediator	0.024688123381725793	0.024688123381725793	+1	TP53,STK11,EP300
GO:0045844	positive regulation of striated muscle tissue development	0.024688123381725793	0.024688123381725793	+1	NOTCH1,ERBB4,FGFR2
GO:1903749	positive regulation of establishment of protein localization to mitochondrion	0.024688123381725793	0.024688123381725793	+1	TP53,FBXW7,BAP1
GO:1901983	regulation of protein acetylation	0.024688123381725793	0.024688123381725793	+1	BRCA1,SMAD4,SIN3A
GO:0046639	negative regulation of alpha-beta T cell differentiation	0.025584509247967485	0.025584509247967485	+1	RUNX1,CBFB
GO:0003171	atrioventricular valve development	0.025584509247967485	0.025584509247967485	+1	NOTCH1,TGFBR2
GO:0003272	endocardial cushion formation	0.025584509247967485	0.025584509247967485	+1	NOTCH1,TGFBR2
GO:0006337	nucleosome disassembly	0.025584509247967485	0.025584509247967485	+1	ARID1A,PBRM1
GO:0048710	regulation of astrocyte differentiation	0.025584509247967485	0.025584509247967485	+1	NOTCH1,MIR142
GO:0048384	retinoic acid receptor signaling pathway	0.025584509247967485	0.025584509247967485	+1	ASXL1,EZH2
GO:2000810	regulation of bicellular tight junction assembly	0.025584509247967485	0.025584509247967485	+1	RUNX1,CBFB
GO:0001709	cell fate determination	0.025584509247967485	0.025584509247967485	+1	GATA3,SOX17
GO:0014014	negative regulation of gliogenesis	0.025584509247967485	0.025584509247967485	+1	NF1,NOTCH1
GO:0007043	cell-cell junction assembly	0.02568356706253976	0.02568356706253976	+1	APC,CDH1,RUNX1,CBFB
GO:1901863	positive regulation of muscle tissue development	0.02568356706253976	0.02568356706253976	+1	NOTCH1,ERBB4,FGFR2
GO:1905818	regulation of chromosome separation	0.02568356706253976	0.02568356706253976	+1	APC,RB1,ATM
GO:1903051	negative regulation of proteolysis involved in cellular protein catabolic process	0.02683575668530318	0.02683575668530318	+1	CDKN2A,TAF1,RPL5
GO:0010812	negative regulation of cell-substrate adhesion	0.02683575668530318	0.02683575668530318	+1	PTEN,CDKN2A,NOTCH1
GO:0070988	demethylation	0.02683575668530318	0.02683575668530318	+1	KDM5C,TET2,USP9X
GO:0060415	muscle tissue morphogenesis	0.02683575668530318	0.02683575668530318	+1	NOTCH1,FGFR2,SMAD4
GO:0048644	muscle organ morphogenesis	0.02683575668530318	0.02683575668530318	+1	NOTCH1,FGFR2,SMAD4
GO:0002218	activation of innate immune response	0.027149037382709497	0.027149037382709497	+1	KRAS,MAP3K1,NRAS,TLR4,EP300,SIN3A
GO:0050869	negative regulation of B cell activation	0.02788604650878293	0.02788604650878293	+1	CDKN2A,ATM
GO:0071459	protein localization to chromosome, centromeric region	0.02788604650878293	0.02788604650878293	+1	RB1,CTCF
GO:0070301	cellular response to hydrogen peroxide	0.02788604650878293	0.02788604650878293	+1	NFE2L2,HGF,LRRK2
GO:0048566	embryonic digestive tract development	0.02788604650878293	0.02788604650878293	+1	PDGFRA,FGFR2
GO:0070723	response to cholesterol	0.02788604650878293	0.02788604650878293	+1	TGFBR2,SMAD2
GO:0055006	cardiac cell development	0.02788604650878293	0.02788604650878293	+1	NOTCH1,PDGFRA,SMAD4
GO:0051567	histone H3-K9 methylation	0.02788604650878293	0.02788604650878293	+1	ATRX,BRCA1
GO:0007026	negative regulation of microtubule depolymerization	0.02788604650878293	0.02788604650878293	+1	APC,NAV3
GO:0042116	macrophage activation	0.02788604650878293	0.02788604650878293	+1	CEBPA,TLR4,MIR142
GO:0006360	transcription by RNA polymerase I	0.02788604650878293	0.02788604650878293	+1	MTOR,TAF1,ERCC2
GO:0014002	astrocyte development	0.02788604650878293	0.02788604650878293	+1	NF1,MIR142
GO:1901798	positive regulation of signal transduction by p53 class mediator	0.02788604650878293	0.02788604650878293	+1	ATM,ATR
GO:0060078	regulation of postsynaptic membrane potential	0.029177554806771994	0.029177554806771994	+1	PTEN,AKT1,LRRK2
GO:0007369	gastrulation	0.029595115145125667	0.029595115145125667	+1	SETD2,FOXA2,SOX17,SMAD2
GO:0006109	regulation of carbohydrate metabolic process	0.029595115145125667	0.029595115145125667	+1	AKT1,EP300,FOXA2,NCOR1
GO:1904886	beta-catenin destruction complex disassembly	0.030151690380336247	0.030151690380336247	+1	APC,CTNNB1
GO:0031498	chromatin disassembly	0.030151690380336247	0.030151690380336247	+1	ARID1A,PBRM1
GO:0035066	positive regulation of histone acetylation	0.030151690380336247	0.030151690380336247	+1	BRCA1,SMAD4
GO:0009299	mRNA transcription	0.030151690380336247	0.030151690380336247	+1	TP53,SOX17
GO:0051298	centrosome duplication	0.030151690380336247	0.030151690380336247	+1	NPM1,BRCA1,BRCA2
GO:2000515	negative regulation of CD4-positive, alpha-beta T cell activation	0.030151690380336247	0.030151690380336247	+1	RUNX1,CBFB
GO:2000573	positive regulation of DNA biosynthetic process	0.030151690380336247	0.030151690380336247	+1	ATM,HGF,ATR
GO:0033135	regulation of peptidyl-serine phosphorylation	0.030151690380336247	0.030151690380336247	+1	EGFR,AKT1,BRAF,NSD1
GO:0009267	cellular response to starvation	0.030151690380336247	0.030151690380336247	+1	TP53,MTOR,LRRK2,CDKN1A
GO:0032986	protein-DNA complex disassembly	0.030151690380336247	0.030151690380336247	+1	ARID1A,PBRM1
GO:0030510	regulation of BMP signaling pathway	0.030151690380336247	0.030151690380336247	+1	NOTCH1,SMAD4,SMAD2
GO:0046640	regulation of alpha-beta T cell proliferation	0.030151690380336247	0.030151690380336247	+1	TGFBR2,MAPK8IP1
GO:0045922	negative regulation of fatty acid metabolic process	0.030151690380336247	0.030151690380336247	+1	AKT1,BRCA1
GO:0030316	osteoclast differentiation	0.030151690380336247	0.030151690380336247	+1	FBXW7,MTOR,TLR4
GO:0032727	positive regulation of interferon-alpha production	0.030151690380336247	0.030151690380336247	+1	TLR4,SETD2
GO:2001236	regulation of extrinsic apoptotic signaling pathway	0.030151690380336247	0.030151690380336247	+1	PTEN,AKT1,AR,BRCA1
GO:2000209	regulation of anoikis	0.030151690380336247	0.030151690380336247	+1	PIK3CA,NOTCH1
GO:0010669	epithelial structure maintenance	0.030151690380336247	0.030151690380336247	+1	SOX9,TLR4
GO:0032069	regulation of nuclease activity	0.030151690380336247	0.030151690380336247	+1	NPM1,AKT1
GO:0070168	negative regulation of biomineral tissue development	0.030151690380336247	0.030151690380336247	+1	NOTCH1,SOX9
GO:0007098	centrosome cycle	0.030983493383728047	0.030983493383728047	+1	CTNNB1,NPM1,BRCA1,BRCA2
GO:0035924	cellular response to vascular endothelial growth factor stimulus	0.03135364046385042	0.03135364046385042	+1	NOTCH1,PDGFRA,EGR3
GO:0060349	bone morphogenesis	0.03135364046385042	0.03135364046385042	+1	SOX9,FGFR2,FGFR3
GO:0002223	stimulatory C-type lectin receptor signaling pathway	0.03135364046385042	0.03135364046385042	+1	KRAS,NRAS,EP300
GO:0002695	negative regulation of leukocyte activation	0.03181968092249253	0.03181968092249253	+1	CDKN2A,RUNX1,ATM,CBFB
GO:0043542	endothelial cell migration	0.03253818156649998	0.03253818156649998	+1	PIK3CA,NF1,GATA3,NOTCH1,AKT1,EGR3
GO:0046599	regulation of centriole replication	0.03260463094371688	0.03260463094371688	+1	NPM1,BRCA1
GO:0048147	negative regulation of fibroblast proliferation	0.03260463094371688	0.03260463094371688	+1	TP53,NF1
GO:0046633	alpha-beta T cell proliferation	0.03260463094371688	0.03260463094371688	+1	TGFBR2,MAPK8IP1
GO:0061515	myeloid cell development	0.03260463094371688	0.03260463094371688	+1	FBXW7,KIT
GO:0055003	cardiac myofibril assembly	0.03260463094371688	0.03260463094371688	+1	PDGFRA,SMAD4
GO:0014741	negative regulation of muscle hypertrophy	0.03260463094371688	0.03260463094371688	+1	NOTCH1,SMAD4
GO:0045943	positive regulation of transcription by RNA polymerase I	0.03260463094371688	0.03260463094371688	+1	MTOR,TAF1
GO:2000108	positive regulation of leukocyte apoptotic process	0.03260463094371688	0.03260463094371688	+1	TP53,CDKN2A
GO:0000724	double-strand break repair via homologous recombination	0.03260463094371688	0.03260463094371688	+1	BRCA1,POLQ,SETD2,BRCA2
GO:0010614	negative regulation of cardiac muscle hypertrophy	0.03260463094371688	0.03260463094371688	+1	NOTCH1,SMAD4
GO:0060541	respiratory system development	0.03260463094371688	0.03260463094371688	+1	CEBPA,WT1,FGFR2
GO:0000725	recombinational repair	0.033466670160505474	0.033466670160505474	+1	BRCA1,POLQ,SETD2,BRCA2
GO:0007272	ensheathment of neurons	0.033844301174620756	0.033844301174620756	+1	PTEN,NF1,PRX
GO:0031058	positive regulation of histone modification	0.033844301174620756	0.033844301174620756	+1	CTNNB1,BRCA1,SMAD4
GO:0008366	axon ensheathment	0.033844301174620756	0.033844301174620756	+1	PTEN,NF1,PRX
GO:0045814	negative regulation of gene expression, epigenetic	0.034360771332101935	0.034360771332101935	+1	DNMT3A,HIST1H1C,SIN3A,EZH2
GO:0006413	translational initiation	0.03468046953476904	0.03468046953476904	+1	NPM1,RPL22,MTOR,EIF4A2,RPL5
GO:0007254	JNK cascade	0.03468046953476904	0.03468046953476904	+1	EGFR,MAP2K4,MAPK8IP1,MECOM,NCOR1
GO:0042307	positive regulation of protein import into nucleus	0.035087814657425366	0.035087814657425366	+1	PIK3R1,CDH1
GO:0060317	cardiac epithelial to mesenchymal transition	0.035087814657425366	0.035087814657425366	+1	NOTCH1,TGFBR2
GO:0071229	cellular response to acid chemical	0.035087814657425366	0.035087814657425366	+1	EPHA3,SOX9,ATM,MTOR
GO:0002220	innate immune response activating cell surface receptor signaling pathway	0.035087814657425366	0.035087814657425366	+1	KRAS,NRAS,EP300
GO:0061311	cell surface receptor signaling pathway involved in heart development	0.035087814657425366	0.035087814657425366	+1	NOTCH1,CTNNB1
GO:0060389	pathway-restricted SMAD protein phosphorylation	0.035087814657425366	0.035087814657425366	+1	SMAD4,TGFBR2,ACVR2A
GO:1902895	positive regulation of pri-miRNA transcription by RNA polymerase II	0.035087814657425366	0.035087814657425366	+1	TP53,WT1
GO:2000273	positive regulation of signaling receptor activity	0.035087814657425366	0.035087814657425366	+1	FBXW7,TAF1
GO:0051865	protein autoubiquitination	0.035087814657425366	0.035087814657425366	+1	BRCA1,LRRK2,TAF1
GO:0051123	RNA polymerase II preinitiation complex assembly	0.035087814657425366	0.035087814657425366	+1	TP53,TAF1
GO:0034405	response to fluid shear stress	0.035087814657425366	0.035087814657425366	+1	NFE2L2,AKT1
GO:0034332	adherens junction organization	0.03594307837924981	0.03594307837924981	+1	PTEN,CTNNB1,CDH1,EPHA3
GO:0043010	camera-type eye development	0.03594307837924981	0.03594307837924981	+1	NF1,SOX9,WT1,PDGFRA
GO:0000187	activation of MAPK activity	0.03594307837924981	0.03594307837924981	+1	MAP2K4,TLR4,LRRK2,KIT
GO:0071887	leukocyte apoptotic process	0.036243297511427484	0.036243297511427484	+1	TP53,CDKN2A,AKT1
GO:0030193	regulation of blood coagulation	0.036243297511427484	0.036243297511427484	+1	TLR4,PDGFRA,FOXA2
GO:1900046	regulation of hemostasis	0.036243297511427484	0.036243297511427484	+1	TLR4,PDGFRA,FOXA2
GO:0030218	erythrocyte differentiation	0.036243297511427484	0.036243297511427484	+1	KIT,ACVR1B,ACVR2A
GO:0007584	response to nutrient	0.036243297511427484	0.036243297511427484	+1	MTOR,FOXA2,TAF1
GO:0036216	cellular response to stem cell factor stimulus	0.03703923425457004	0.03703923425457004	+1	KIT
GO:0036369	transcription factor catabolic process	0.03703923425457004	0.03703923425457004	+1	TAF1
GO:0038109	Kit signaling pathway	0.03703923425457004	0.03703923425457004	+1	KIT
GO:0043974	histone H3-K27 acetylation	0.03703923425457004	0.03703923425457004	+1	SIN3A
GO:0043006	activation of phospholipase A2 activity by calcium-mediated signaling	0.03703923425457004	0.03703923425457004	+1	EGFR
GO:0002663	positive regulation of B cell tolerance induction	0.03703923425457004	0.03703923425457004	+1	TGFBR2
GO:0002661	regulation of B cell tolerance induction	0.03703923425457004	0.03703923425457004	+1	TGFBR2
GO:0031114	regulation of microtubule depolymerization	0.03703923425457004	0.03703923425457004	+1	APC,NAV3
GO:0036314	response to sterol	0.03703923425457004	0.03703923425457004	+1	TGFBR2,SMAD2
GO:0003252	negative regulation of cell proliferation involved in heart valve morphogenesis	0.03703923425457004	0.03703923425457004	+1	NOTCH1
GO:0035359	negative regulation of peroxisome proliferator activated receptor signaling pathway	0.03703923425457004	0.03703923425457004	+1	ASXL1
GO:0044262	cellular carbohydrate metabolic process	0.03703923425457004	0.03703923425457004	+1	PTEN,AKT1,BRAF,EP300,FOXA2
GO:0003250	regulation of cell proliferation involved in heart valve morphogenesis	0.03703923425457004	0.03703923425457004	+1	NOTCH1
GO:0003249	cell proliferation involved in heart valve morphogenesis	0.03703923425457004	0.03703923425457004	+1	NOTCH1
GO:0003220	left ventricular cardiac muscle tissue morphogenesis	0.03703923425457004	0.03703923425457004	+1	SMAD4
GO:0000717	nucleotide-excision repair, DNA duplex unwinding	0.03703923425457004	0.03703923425457004	+1	ERCC2
GO:0048866	stem cell fate specification	0.03703923425457004	0.03703923425457004	+1	SOX9
GO:0032707	negative regulation of interleukin-23 production	0.03703923425457004	0.03703923425457004	+1	TLR4
GO:0034770	histone H4-K20 methylation	0.03703923425457004	0.03703923425457004	+1	BRCA1
GO:0046632	alpha-beta T cell differentiation	0.03703923425457004	0.03703923425457004	+1	RUNX1,TGFBR2,CBFB
GO:0003169	coronary vein morphogenesis	0.03703923425457004	0.03703923425457004	+1	NOTCH1
GO:0045976	negative regulation of mitotic cell cycle, embryonic	0.03703923425457004	0.03703923425457004	+1	CTNNB1
GO:0048617	embryonic foregut morphogenesis	0.03703923425457004	0.03703923425457004	+1	SOX17
GO:0045740	positive regulation of DNA replication	0.03703923425457004	0.03703923425457004	+1	EGFR,ATRX
GO:0045720	negative regulation of integrin biosynthetic process	0.03703923425457004	0.03703923425457004	+1	AR
GO:0045639	positive regulation of myeloid cell differentiation	0.03703923425457004	0.03703923425457004	+1	RUNX1,ACVR1B,ACVR2A
GO:0045084	positive regulation of interleukin-12 biosynthetic process	0.03703923425457004	0.03703923425457004	+1	TLR4
GO:0035710	CD4-positive, alpha-beta T cell activation	0.03703923425457004	0.03703923425457004	+1	RUNX1,TGFBR2,CBFB
GO:0035801	adrenal cortex development	0.03703923425457004	0.03703923425457004	+1	WT1
GO:0035802	adrenal cortex formation	0.03703923425457004	0.03703923425457004	+1	WT1
GO:0044334	canonical Wnt signaling pathway involved in positive regulation of epithelial to mesenchymal transition	0.03703923425457004	0.03703923425457004	+1	CTNNB1
GO:0036215	response to stem cell factor	0.03703923425457004	0.03703923425457004	+1	KIT
GO:1903463	regulation of mitotic cell cycle DNA replication	0.03703923425457004	0.03703923425457004	+1	CHEK2
GO:0072166	posterior mesonephric tubule development	0.03703923425457004	0.03703923425457004	+1	WT1
GO:0072301	regulation of metanephric glomerular mesangial cell proliferation	0.03703923425457004	0.03703923425457004	+1	WT1
GO:0099404	mitotic sister chromatid cohesion, telomeric	0.03703923425457004	0.03703923425457004	+1	ATRX
GO:0140066	peptidyl-lysine crotonylation	0.03703923425457004	0.03703923425457004	+1	EP300
GO:1900224	positive regulation of nodal signaling pathway involved in determination of lateral mesoderm left/right asymmetry	0.03703923425457004	0.03703923425457004	+1	SMAD2
GO:0021860	pyramidal neuron development	0.03703923425457004	0.03703923425457004	+1	FGFR2
GO:0060948	cardiac vascular smooth muscle cell development	0.03703923425457004	0.03703923425457004	+1	NOTCH1
GO:0060916	mesenchymal cell proliferation involved in lung development	0.03703923425457004	0.03703923425457004	+1	FGFR2
GO:0007352	zygotic specification of dorsal/ventral axis	0.03703923425457004	0.03703923425457004	+1	SMAD2
GO:1904761	negative regulation of myofibroblast differentiation	0.03703923425457004	0.03703923425457004	+1	RB1
GO:2000468	regulation of peroxidase activity	0.03703923425457004	0.03703923425457004	+1	LRRK2
GO:0060693	regulation of branching involved in salivary gland morphogenesis	0.03703923425457004	0.03703923425457004	+1	HGF
GO:2001074	regulation of metanephric ureteric bud development	0.03703923425457004	0.03703923425457004	+1	WT1
GO:0080111	DNA demethylation	0.03703923425457004	0.03703923425457004	+1	TET2,USP9X
GO:2001076	positive regulation of metanephric ureteric bud development	0.03703923425457004	0.03703923425457004	+1	WT1
GO:1990418	response to insulin-like growth factor stimulus	0.03703923425457004	0.03703923425457004	+1	AKT1
GO:0060767	epithelial cell proliferation involved in prostate gland development	0.03703923425457004	0.03703923425457004	+1	SOX9
GO:0021869	forebrain ventricular zone progenitor cell division	0.03703923425457004	0.03703923425457004	+1	FGFR2
GO:0061031	endodermal digestive tract morphogenesis	0.03703923425457004	0.03703923425457004	+1	SOX17
GO:0099403	maintenance of mitotic sister chromatid cohesion, telomeric	0.03703923425457004	0.03703923425457004	+1	ATRX
GO:0016578	histone deubiquitination	0.03703923425457004	0.03703923425457004	+1	BAP1,ASXL1
GO:1905279	regulation of retrograde transport, endosome to Golgi	0.03703923425457004	0.03703923425457004	+1	LRRK2
GO:2000639	negative regulation of SREBP signaling pathway	0.03703923425457004	0.03703923425457004	+1	FBXW7
GO:2000620	positive regulation of histone H4-K16 acetylation	0.03703923425457004	0.03703923425457004	+1	BRCA1
GO:1905863	invadopodium organization	0.03703923425457004	0.03703923425457004	+1	NAV3
GO:0007406	negative regulation of neuroblast proliferation	0.03703923425457004	0.03703923425457004	+1	NF1
GO:0071866	negative regulation of apoptotic process in bone marrow cell	0.03703923425457004	0.03703923425457004	+1	FGFR2
GO:0072034	renal vesicle induction	0.03703923425457004	0.03703923425457004	+1	SOX9
GO:0010768	negative regulation of transcription from RNA polymerase II promoter in response to UV-induced DNA damage	0.03703923425457004	0.03703923425457004	+1	TAF1
GO:0098679	regulation of carbohydrate catabolic process by regulation of transcription from RNA polymerase II promoter	0.03703923425457004	0.03703923425457004	+1	NCOR1
GO:2000758	positive regulation of peptidyl-lysine acetylation	0.03703923425457004	0.03703923425457004	+1	BRCA1,SMAD4
GO:1904908	negative regulation of maintenance of mitotic sister chromatid cohesion, telomeric	0.03703923425457004	0.03703923425457004	+1	ATRX
GO:1990428	miRNA transport	0.03703923425457004	0.03703923425457004	+1	TGFBR2
GO:1904907	regulation of maintenance of mitotic sister chromatid cohesion, telomeric	0.03703923425457004	0.03703923425457004	+1	ATRX
GO:0021872	forebrain generation of neurons	0.03703923425457004	0.03703923425457004	+1	ERBB4,FGFR2
GO:2000683	regulation of cellular response to X-ray	0.03703923425457004	0.03703923425457004	+1	GATA3
GO:0060664	epithelial cell proliferation involved in salivary gland morphogenesis	0.03703923425457004	0.03703923425457004	+1	FGFR2
GO:0010906	regulation of glucose metabolic process	0.03703923425457004	0.03703923425457004	+1	AKT1,EP300,FOXA2
GO:0060595	fibroblast growth factor receptor signaling pathway involved in mammary gland specification	0.03703923425457004	0.03703923425457004	+1	FGFR2
GO:0097324	melanocyte migration	0.03703923425457004	0.03703923425457004	+1	KIT
GO:0060056	mammary gland involution	0.03703923425457004	0.03703923425457004	+1	ELF3
GO:0007440	foregut morphogenesis	0.03703923425457004	0.03703923425457004	+1	SOX17
GO:2000346	negative regulation of hepatocyte proliferation	0.03703923425457004	0.03703923425457004	+1	FBXW7
GO:1903336	negative regulation of vacuolar transport	0.03703923425457004	0.03703923425457004	+1	LRRK2
GO:0060024	rhythmic synaptic transmission	0.03703923425457004	0.03703923425457004	+1	PTEN
GO:1905524	negative regulation of protein autoubiquitination	0.03703923425457004	0.03703923425457004	+1	TAF1
GO:0072368	regulation of lipid transport by negative regulation of transcription from RNA polymerase II promoter	0.03703923425457004	0.03703923425457004	+1	NCOR1
GO:0071372	cellular response to follicle-stimulating hormone stimulus	0.03703923425457004	0.03703923425457004	+1	NOTCH1
GO:1903378	positive regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway	0.03703923425457004	0.03703923425457004	+1	FBXW7
GO:2000195	negative regulation of female gonad development	0.03703923425457004	0.03703923425457004	+1	WT1
GO:0007538	primary sex determination	0.03703923425457004	0.03703923425457004	+1	SOX9
GO:1903464	negative regulation of mitotic cell cycle DNA replication	0.03703923425457004	0.03703923425457004	+1	CHEK2
GO:0021551	central nervous system morphogenesis	0.03703923425457004	0.03703923425457004	+1	ERBB4
GO:0097156	fasciculation of motor neuron axon	0.03703923425457004	0.03703923425457004	+1	EPHA3
GO:1902823	negative regulation of late endosome to lysosome transport	0.03703923425457004	0.03703923425457004	+1	LRRK2
GO:0060601	lateral sprouting from an epithelium	0.03703923425457004	0.03703923425457004	+1	FGFR2
GO:0060221	retinal rod cell differentiation	0.03703923425457004	0.03703923425457004	+1	SOX9
GO:0072361	regulation of glycolytic process by regulation of transcription from RNA polymerase II promoter	0.03703923425457004	0.03703923425457004	+1	NCOR1
GO:0060594	mammary gland specification	0.03703923425457004	0.03703923425457004	+1	FGFR2
GO:1901674	regulation of histone H3-K27 acetylation	0.03703923425457004	0.03703923425457004	+1	SIN3A
GO:0021859	pyramidal neuron differentiation	0.03703923425457004	0.03703923425457004	+1	FGFR2
GO:1901963	regulation of cell proliferation involved in outflow tract morphogenesis	0.03703923425457004	0.03703923425457004	+1	CTNNB1
GO:0060592	mammary gland formation	0.03703923425457004	0.03703923425457004	+1	FGFR2
GO:0060572	morphogenesis of an epithelial bud	0.03703923425457004	0.03703923425457004	+1	FGFR2
GO:0060484	lung-associated mesenchyme development	0.03703923425457004	0.03703923425457004	+1	FGFR2
GO:1902751	positive regulation of cell cycle G2/M phase transition	0.03703923425457004	0.03703923425457004	+1	NPM1,CCND1
GO:0021847	ventricular zone neuroblast division	0.03703923425457004	0.03703923425457004	+1	FGFR2
GO:0060442	branching involved in prostate gland morphogenesis	0.03703923425457004	0.03703923425457004	+1	FGFR2
GO:1904028	positive regulation of collagen fibril organization	0.03703923425457004	0.03703923425457004	+1	RB1
GO:1902499	positive regulation of protein autoubiquitination	0.03703923425457004	0.03703923425457004	+1	LRRK2
GO:0060260	regulation of transcription initiation from RNA polymerase II promoter	0.03703923425457004	0.03703923425457004	+1	TP53,TAF1
GO:0014036	neural crest cell fate specification	0.03703923425457004	0.03703923425457004	+1	SOX9
GO:1905289	regulation of CAMKK-AMPK signaling cascade	0.03703923425457004	0.03703923425457004	+1	LRRK2
GO:0042098	T cell proliferation	0.03748689758329515	0.03748689758329515	+1	CDKN2A,PIK3CG,TGFBR2,MAPK8IP1
GO:0045589	regulation of regulatory T cell differentiation	0.0378916453571834	0.0378916453571834	+1	RUNX1,CBFB
GO:1903363	negative regulation of cellular protein catabolic process	0.0378916453571834	0.0378916453571834	+1	CDKN2A,TAF1,RPL5
GO:1990874	vascular smooth muscle cell proliferation	0.0378916453571834	0.0378916453571834	+1	PTEN,CDKN1B,CDKN1A
GO:0043303	mast cell degranulation	0.0378916453571834	0.0378916453571834	+1	PIK3CG,KIT
GO:0045833	negative regulation of lipid metabolic process	0.0378916453571834	0.0378916453571834	+1	FBXW7,AKT1,BRCA1
GO:0043407	negative regulation of MAP kinase activity	0.0378916453571834	0.0378916453571834	+1	NF1,PPP2R1A,MAPK8IP1
GO:0045742	positive regulation of epidermal growth factor receptor signaling pathway	0.0378916453571834	0.0378916453571834	+1	FBXW7,AKT1
GO:0045648	positive regulation of erythrocyte differentiation	0.0378916453571834	0.0378916453571834	+1	ACVR1B,ACVR2A
GO:0051154	negative regulation of striated muscle cell differentiation	0.0378916453571834	0.0378916453571834	+1	NOTCH1,SMAD4
GO:1904705	regulation of vascular smooth muscle cell proliferation	0.0378916453571834	0.0378916453571834	+1	PTEN,CDKN1B,CDKN1A
GO:0050855	regulation of B cell receptor signaling pathway	0.0378916453571834	0.0378916453571834	+1	RUNX1,CBFB
GO:0001942	hair follicle development	0.0378916453571834	0.0378916453571834	+1	SOX9,FGFR2
GO:0061001	regulation of dendritic spine morphogenesis	0.0378916453571834	0.0378916453571834	+1	PTEN,LRRK2
GO:0098815	modulation of excitatory postsynaptic potential	0.0378916453571834	0.0378916453571834	+1	PTEN,LRRK2
GO:0000729	DNA double-strand break processing	0.0378916453571834	0.0378916453571834	+1	ATM,BRCA1
GO:0062014	negative regulation of small molecule metabolic process	0.0378916453571834	0.0378916453571834	+1	AKT1,BRCA1,EP300
GO:0017145	stem cell division	0.0378916453571834	0.0378916453571834	+1	CDKN2A,FGFR2
GO:0010499	proteasomal ubiquitin-independent protein catabolic process	0.0378916453571834	0.0378916453571834	+1	KEAP1,NFE2L2
GO:1904591	positive regulation of protein import	0.0378916453571834	0.0378916453571834	+1	PIK3R1,CDH1
GO:0042594	response to starvation	0.03800279987642908	0.03800279987642908	+1	TP53,MTOR,LRRK2,CDKN1A
GO:0030258	lipid modification	0.03827685891486283	0.03827685891486283	+1	PIK3CA,PTEN,PIK3R1,AKT1,PIK3CG
GO:0034101	erythrocyte homeostasis	0.039126987118395705	0.039126987118395705	+1	KIT,ACVR1B,ACVR2A
GO:0030901	midbrain development	0.039126987118395705	0.039126987118395705	+1	CTNNB1,FGFR2,TAF1
GO:1903533	regulation of protein targeting	0.039126987118395705	0.039126987118395705	+1	FBXW7,BAP1,LRRK2
GO:0050818	regulation of coagulation	0.039126987118395705	0.039126987118395705	+1	TLR4,PDGFRA,FOXA2
GO:0051984	positive regulation of chromosome segregation	0.040261691539102605	0.040261691539102605	+1	RB1,RAD21
GO:0055094	response to lipoprotein particle	0.040261691539102605	0.040261691539102605	+1	AKT1,TLR4
GO:0097485	neuron projection guidance	0.040261691539102605	0.040261691539102605	+1	PIK3CA,PIK3R1,ARHGAP35,EPHA3,PTPN11
GO:0032647	regulation of interferon-alpha production	0.040261691539102605	0.040261691539102605	+1	TLR4,SETD2
GO:0022405	hair cycle process	0.040261691539102605	0.040261691539102605	+1	SOX9,FGFR2
GO:0032607	interferon-alpha production	0.040261691539102605	0.040261691539102605	+1	TLR4,SETD2
GO:0022404	molting cycle process	0.040261691539102605	0.040261691539102605	+1	SOX9,FGFR2
GO:0002448	mast cell mediated immunity	0.040261691539102605	0.040261691539102605	+1	PIK3CG,KIT
GO:0007411	axon guidance	0.040261691539102605	0.040261691539102605	+1	PIK3CA,PIK3R1,ARHGAP35,EPHA3,PTPN11
GO:0006476	protein deacetylation	0.040261691539102605	0.040261691539102605	+1	EP300,SIN3A,TBL1XR1
GO:0002279	mast cell activation involved in immune response	0.040261691539102605	0.040261691539102605	+1	PIK3CG,KIT
GO:0060765	regulation of androgen receptor signaling pathway	0.040261691539102605	0.040261691539102605	+1	EP300,NCOR1
GO:0060416	response to growth hormone	0.040261691539102605	0.040261691539102605	+1	PIK3R1,AKT1
GO:0006739	NADP metabolic process	0.040261691539102605	0.040261691539102605	+1	IDH1,IDH2
GO:0032890	regulation of organic acid transport	0.040261691539102605	0.040261691539102605	+1	AKT1,NCOR1
GO:0031023	microtubule organizing center organization	0.04050625520832632	0.04050625520832632	+1	CTNNB1,NPM1,BRCA1,BRCA2
GO:0045216	cell-cell junction organization	0.04050625520832632	0.04050625520832632	+1	APC,CDH1,RUNX1,CBFB
GO:0006446	regulation of translational initiation	0.04173293078808834	0.04173293078808834	+1	NPM1,MTOR,EIF4A2
GO:0043543	protein acylation	0.04174806420685865	0.04174806420685865	+1	BRCA1,EP300,SMAD4,BRCA2,SIN3A
GO:0061448	connective tissue development	0.0425735613773717	0.0425735613773717	+1	SOX9,WT1,ARID5B,FGFR3
GO:0045066	regulatory T cell differentiation	0.042882080508866	0.042882080508866	+1	RUNX1,CBFB
GO:1901186	positive regulation of ERBB signaling pathway	0.042882080508866	0.042882080508866	+1	FBXW7,AKT1
GO:0098773	skin epidermis development	0.042882080508866	0.042882080508866	+1	SOX9,FGFR2
GO:0045429	positive regulation of nitric oxide biosynthetic process	0.042882080508866	0.042882080508866	+1	AKT1,TLR4
GO:1904407	positive regulation of nitric oxide metabolic process	0.042882080508866	0.042882080508866	+1	AKT1,TLR4
GO:0070231	T cell apoptotic process	0.042882080508866	0.042882080508866	+1	TP53,AKT1
GO:0010543	regulation of platelet activation	0.042882080508866	0.042882080508866	+1	TLR4,PDGFRA
GO:0071276	cellular response to cadmium ion	0.042882080508866	0.042882080508866	+1	EGFR,AKT1
GO:0071402	cellular response to lipoprotein particle stimulus	0.042882080508866	0.042882080508866	+1	AKT1,TLR4
GO:0070167	regulation of biomineral tissue development	0.04291855879013722	0.04291855879013722	+1	NOTCH1,SOX9,ACVR2A
GO:0060173	limb development	0.04291855879013722	0.04291855879013722	+1	CTNNB1,TBX3,FGFR2
GO:0034333	adherens junction assembly	0.04291855879013722	0.04291855879013722	+1	PTEN,CTNNB1,EPHA3
GO:0048736	appendage development	0.04291855879013722	0.04291855879013722	+1	CTNNB1,TBX3,FGFR2
GO:0006470	protein dephosphorylation	0.04304996966072685	0.04304996966072685	+1	PTEN,STK11,MTOR,PPP2R1A,PTPN11
GO:0051100	negative regulation of binding	0.04327834652848661	0.04327834652848661	+1	AKT1,LRRK2,TAF1,SIN3A
GO:0042542	response to hydrogen peroxide	0.04431093835828437	0.04431093835828437	+1	NFE2L2,HGF,LRRK2
GO:0006283	transcription-coupled nucleotide-excision repair	0.04431093835828437	0.04431093835828437	+1	CRIPAK,EP300,ERCC2
GO:1905897	regulation of response to endoplasmic reticulum stress	0.04431093835828437	0.04431093835828437	+1	PIK3R1,NFE2L2,LRRK2
GO:0046677	response to antibiotic	0.04431093835828437	0.04431093835828437	+1	TP53,NFE2L2,HGF,LRRK2
GO:0030282	bone mineralization	0.04431093835828437	0.04431093835828437	+1	FGFR2,FGFR3,ACVR2A
GO:0032872	regulation of stress-activated MAPK cascade	0.04456938455410107	0.04456938455410107	+1	EGFR,MAP2K4,MAPK8IP1,MECOM,NCOR1
GO:0042593	glucose homeostasis	0.04527084295685752	0.04527084295685752	+1	PIK3R1,STK11,CEBPA,FOXA2
GO:0090288	negative regulation of cellular response to growth factor stimulus	0.04527084295685752	0.04527084295685752	+1	GATA3,NOTCH1,TGFBR2,SMAD2
GO:0042472	inner ear morphogenesis	0.045340215025123996	0.045340215025123996	+1	SOX9,FGFR2
GO:0031018	endocrine pancreas development	0.045340215025123996	0.045340215025123996	+1	AKT1,FOXA2
GO:0046636	negative regulation of alpha-beta T cell activation	0.045340215025123996	0.045340215025123996	+1	RUNX1,CBFB
GO:0032728	positive regulation of interferon-beta production	0.045340215025123996	0.045340215025123996	+1	TLR4,PTPN11
GO:0010677	negative regulation of cellular carbohydrate metabolic process	0.045340215025123996	0.045340215025123996	+1	EP300,FOXA2
GO:0071354	cellular response to interleukin-6	0.045340215025123996	0.045340215025123996	+1	SMAD4,PTPN11
GO:2000352	negative regulation of endothelial cell apoptotic process	0.045340215025123996	0.045340215025123996	+1	GATA3,NFE2L2
GO:0045616	regulation of keratinocyte differentiation	0.045340215025123996	0.045340215025123996	+1	RUNX1,CBFB
GO:0070302	regulation of stress-activated protein kinase signaling cascade	0.045340215025123996	0.045340215025123996	+1	EGFR,MAP2K4,MAPK8IP1,MECOM,NCOR1
GO:0033500	carbohydrate homeostasis	0.04614519026146321	0.04614519026146321	+1	PIK3R1,STK11,CEBPA,FOXA2
GO:0098732	macromolecule deacylation	0.04715453223317848	0.04715453223317848	+1	EP300,SIN3A,TBL1XR1
GO:0035601	protein deacylation	0.04715453223317848	0.04715453223317848	+1	EP300,SIN3A,TBL1XR1
GO:0042058	regulation of epidermal growth factor receptor signaling pathway	0.04715453223317848	0.04715453223317848	+1	EGFR,FBXW7,AKT1
GO:0031572	G2 DNA damage checkpoint	0.048099721241219855	0.048099721241219855	+1	ATM,BRCA1
GO:0070897	transcription preinitiation complex assembly	0.048099721241219855	0.048099721241219855	+1	TP53,TAF1
GO:0046825	regulation of protein export from nucleus	0.048099721241219855	0.048099721241219855	+1	TP53,SETD2
GO:0097028	dendritic cell differentiation	0.048099721241219855	0.048099721241219855	+1	FLT3,TGFBR2
GO:0001658	branching involved in ureteric bud morphogenesis	0.048099721241219855	0.048099721241219855	+1	SOX9,WT1
GO:0001959	regulation of cytokine-mediated signaling pathway	0.048099721241219855	0.048099721241219855	+1	RUNX1,CBFB,PTPN11,LIFR
GO:0031057	negative regulation of histone modification	0.048099721241219855	0.048099721241219855	+1	BRCA1,SIN3A
GO:0021761	limbic system development	0.048099721241219855	0.048099721241219855	+1	PTEN,FGFR2
GO:0032204	regulation of telomere maintenance	0.048525592074879755	0.048525592074879755	+1	ATM,ATRX,ATR
GO:0001776	leukocyte homeostasis	0.04903679173714133	0.04903679173714133	+1	FLT3,AKT1
GO:0000430	regulation of transcription from RNA polymerase II promoter by glucose	0.04903679173714133	0.04903679173714133	+1	FOXA2
GO:0000432	positive regulation of transcription from RNA polymerase II promoter by glucose	0.04903679173714133	0.04903679173714133	+1	FOXA2
GO:0002318	myeloid progenitor cell differentiation	0.04903679173714133	0.04903679173714133	+1	FLT3
GO:0002262	myeloid cell homeostasis	0.04903679173714133	0.04903679173714133	+1	KIT,ACVR1B,ACVR2A
GO:0002331	pre-B cell allelic exclusion	0.04903679173714133	0.04903679173714133	+1	ATM
GO:0001704	formation of primary germ layer	0.04903679173714133	0.04903679173714133	+1	SETD2,SOX17,SMAD2
GO:0042766	nucleosome mobilization	0.04903679173714133	0.04903679173714133	+1	ARID1A
GO:0002514	B cell tolerance induction	0.04903679173714133	0.04903679173714133	+1	TGFBR2
GO:0048873	homeostasis of number of cells within a tissue	0.04903679173714133	0.04903679173714133	+1	SOX9
GO:0032808	lacrimal gland development	0.04903679173714133	0.04903679173714133	+1	FGFR2
GO:0032497	detection of lipopolysaccharide	0.04903679173714133	0.04903679173714133	+1	TLR4
GO:0050868	negative regulation of T cell activation	0.04903679173714133	0.04903679173714133	+1	CDKN2A,RUNX1,CBFB
GO:0032354	response to follicle-stimulating hormone	0.04903679173714133	0.04903679173714133	+1	NOTCH1
GO:0032286	central nervous system myelin maintenance	0.04903679173714133	0.04903679173714133	+1	PTEN
GO:0051136	regulation of NK T cell differentiation	0.04903679173714133	0.04903679173714133	+1	TGFBR2
GO:0031999	negative regulation of fatty acid beta-oxidation	0.04903679173714133	0.04903679173714133	+1	AKT1
GO:0031935	regulation of chromatin silencing	0.04903679173714133	0.04903679173714133	+1	HIST1H1C,SIN3A
GO:0051443	positive regulation of ubiquitin-protein transferase activity	0.04903679173714133	0.04903679173714133	+1	PTEN,FBXW7
GO:0031134	sister chromatid biorientation	0.04903679173714133	0.04903679173714133	+1	RB1
GO:0048861	leukemia inhibitory factor signaling pathway	0.04903679173714133	0.04903679173714133	+1	LIFR
GO:0030997	regulation of centriole-centriole cohesion	0.04903679173714133	0.04903679173714133	+1	CTNNB1
GO:0060374	mast cell differentiation	0.04903679173714133	0.04903679173714133	+1	KIT
GO:0060501	positive regulation of epithelial cell proliferation involved in lung morphogenesis	0.04903679173714133	0.04903679173714133	+1	FGFR2
GO:0060742	epithelial cell differentiation involved in prostate gland development	0.04903679173714133	0.04903679173714133	+1	FGFR2
GO:0060913	cardiac cell fate determination	0.04903679173714133	0.04903679173714133	+1	SOX17
GO:0061209	cell proliferation involved in mesonephros development	0.04903679173714133	0.04903679173714133	+1	GATA3
GO:0061218	negative regulation of mesonephros development	0.04903679173714133	0.04903679173714133	+1	GATA3
GO:0061325	cell proliferation involved in outflow tract morphogenesis	0.04903679173714133	0.04903679173714133	+1	CTNNB1
GO:0022028	tangential migration from the subventricular zone to the olfactory bulb	0.04903679173714133	0.04903679173714133	+1	LRRK2
GO:0070662	mast cell proliferation	0.04903679173714133	0.04903679173714133	+1	KIT
GO:0019857	5-methylcytosine metabolic process	0.04903679173714133	0.04903679173714133	+1	TET2
GO:0071839	apoptotic process in bone marrow cell	0.04903679173714133	0.04903679173714133	+1	FGFR2
GO:0060214	endocardium formation	0.04903679173714133	0.04903679173714133	+1	SOX17
GO:0071865	regulation of apoptotic process in bone marrow cell	0.04903679173714133	0.04903679173714133	+1	FGFR2
GO:0034092	negative regulation of maintenance of sister chromatid cohesion	0.04903679173714133	0.04903679173714133	+1	ATRX
GO:0048386	positive regulation of retinoic acid receptor signaling pathway	0.04903679173714133	0.04903679173714133	+1	ASXL1
GO:0042306	regulation of protein import into nucleus	0.04903679173714133	0.04903679173714133	+1	PIK3R1,CDH1
GO:0042090	interleukin-12 biosynthetic process	0.04903679173714133	0.04903679173714133	+1	TLR4
GO:0043516	regulation of DNA damage response, signal transduction by p53 class mediator	0.04903679173714133	0.04903679173714133	+1	ATM,ATR
GO:0040036	regulation of fibroblast growth factor receptor signaling pathway	0.04903679173714133	0.04903679173714133	+1	GATA3,FGFR2
GO:0040019	positive regulation of embryonic development	0.04903679173714133	0.04903679173714133	+1	GATA3,FOXA2
GO:0038162	erythropoietin-mediated signaling pathway	0.04903679173714133	0.04903679173714133	+1	KIT
GO:0038091	positive regulation of cell proliferation by VEGF-activated platelet derived growth factor receptor signaling pathway	0.04903679173714133	0.04903679173714133	+1	PDGFRA
GO:0038086	VEGF-activated platelet-derived growth factor receptor signaling pathway	0.04903679173714133	0.04903679173714133	+1	PDGFRA
GO:0036023	embryonic skeletal limb joint morphogenesis	0.04903679173714133	0.04903679173714133	+1	CTNNB1
GO:0036022	limb joint morphogenesis	0.04903679173714133	0.04903679173714133	+1	CTNNB1
GO:0035986	senescence-associated heterochromatin focus assembly	0.04903679173714133	0.04903679173714133	+1	CDKN2A
GO:0034183	negative regulation of maintenance of mitotic sister chromatid cohesion	0.04903679173714133	0.04903679173714133	+1	ATRX
GO:0045075	regulation of interleukin-12 biosynthetic process	0.04903679173714133	0.04903679173714133	+1	TLR4
GO:0035564	regulation of kidney size	0.04903679173714133	0.04903679173714133	+1	LRRK2
GO:0045726	positive regulation of integrin biosynthetic process	0.04903679173714133	0.04903679173714133	+1	AR
GO:0035510	DNA dealkylation	0.04903679173714133	0.04903679173714133	+1	TET2,USP9X
GO:0045967	negative regulation of growth rate	0.04903679173714133	0.04903679173714133	+1	NOTCH1
GO:0046016	positive regulation of transcription by glucose	0.04903679173714133	0.04903679173714133	+1	FOXA2
GO:0046532	regulation of photoreceptor cell differentiation	0.04903679173714133	0.04903679173714133	+1	SOX9
GO:0046533	negative regulation of photoreceptor cell differentiation	0.04903679173714133	0.04903679173714133	+1	SOX9
GO:0046686	response to cadmium ion	0.04903679173714133	0.04903679173714133	+1	EGFR,AKT1
GO:0048339	paraxial mesoderm development	0.04903679173714133	0.04903679173714133	+1	SMAD2
GO:0048340	paraxial mesoderm morphogenesis	0.04903679173714133	0.04903679173714133	+1	SMAD2
GO:0045448	mitotic cell cycle, embryonic	0.04903679173714133	0.04903679173714133	+1	CTNNB1
GO:0002513	tolerance induction to self antigen	0.04903679173714133	0.04903679173714133	+1	TGFBR2
GO:0071930	negative regulation of transcription involved in G1/S transition of mitotic cell cycle	0.04903679173714133	0.04903679173714133	+1	RB1
GO:0072179	nephric duct formation	0.04903679173714133	0.04903679173714133	+1	GATA3
GO:1904760	regulation of myofibroblast differentiation	0.04903679173714133	0.04903679173714133	+1	RB1
GO:1905457	negative regulation of lymphoid progenitor cell differentiation	0.04903679173714133	0.04903679173714133	+1	NOTCH1
GO:1905940	negative regulation of gonad development	0.04903679173714133	0.04903679173714133	+1	WT1
GO:2000111	positive regulation of macrophage apoptotic process	0.04903679173714133	0.04903679173714133	+1	CDKN2A
GO:2000172	regulation of branching morphogenesis of a nerve	0.04903679173714133	0.04903679173714133	+1	LRRK2
GO:2000609	regulation of thyroid hormone generation	0.04903679173714133	0.04903679173714133	+1	GATA3
GO:2000611	positive regulation of thyroid hormone generation	0.04903679173714133	0.04903679173714133	+1	GATA3
GO:2000638	regulation of SREBP signaling pathway	0.04903679173714133	0.04903679173714133	+1	FBXW7
GO:0007182	common-partner SMAD protein phosphorylation	0.04903679173714133	0.04903679173714133	+1	SMAD2
GO:2000793	cell proliferation involved in heart valve development	0.04903679173714133	0.04903679173714133	+1	NOTCH1
GO:2000807	regulation of synaptic vesicle clustering	0.04903679173714133	0.04903679173714133	+1	PTEN
GO:0072125	negative regulation of glomerular mesangial cell proliferation	0.04903679173714133	0.04903679173714133	+1	WT1
GO:2000825	positive regulation of androgen receptor activity	0.04903679173714133	0.04903679173714133	+1	TAF1
GO:2001023	regulation of response to drug	0.04903679173714133	0.04903679173714133	+1	NFE2L2,HGF,LRRK2
GO:2001205	negative regulation of osteoclast development	0.04903679173714133	0.04903679173714133	+1	FBXW7
GO:0006990	positive regulation of transcription from RNA polymerase II promoter involved in unfolded protein response	0.04903679173714133	0.04903679173714133	+1	EP300
GO:0006407	rRNA export from nucleus	0.04903679173714133	0.04903679173714133	+1	NPM1
GO:0006356	regulation of transcription by RNA polymerase I	0.04903679173714133	0.04903679173714133	+1	MTOR,TAF1
GO:0006211	5-methylcytosine catabolic process	0.04903679173714133	0.04903679173714133	+1	TET2
GO:0005991	trehalose metabolic process	0.04903679173714133	0.04903679173714133	+1	BRAF
GO:0003273	cell migration involved in endocardial cushion formation	0.04903679173714133	0.04903679173714133	+1	NOTCH1
GO:0003192	mitral valve formation	0.04903679173714133	0.04903679173714133	+1	NOTCH1
GO:0002762	negative regulation of myeloid leukocyte differentiation	0.04903679173714133	0.04903679173714133	+1	FBXW7,TLR4
GO:0002666	positive regulation of T cell tolerance induction	0.04903679173714133	0.04903679173714133	+1	TGFBR2
GO:2000974	negative regulation of pro-B cell differentiation	0.04903679173714133	0.04903679173714133	+1	NOTCH1
GO:1903974	positive regulation of cellular response to macrophage colony-stimulating factor stimulus	0.04903679173714133	0.04903679173714133	+1	TLR4
GO:1903984	positive regulation of TRAIL-activated apoptotic signaling pathway	0.04903679173714133	0.04903679173714133	+1	PTEN
GO:1903691	positive regulation of wound healing, spreading of epidermal cells	0.04903679173714133	0.04903679173714133	+1	MTOR
GO:0072262	metanephric glomerular mesangial cell proliferation involved in metanephros development	0.04903679173714133	0.04903679173714133	+1	WT1
GO:0072275	metanephric glomerulus morphogenesis	0.04903679173714133	0.04903679173714133	+1	PDGFRA
GO:0072276	metanephric glomerulus vasculature morphogenesis	0.04903679173714133	0.04903679173714133	+1	PDGFRA
GO:0072277	metanephric glomerular capillary formation	0.04903679173714133	0.04903679173714133	+1	PDGFRA
GO:0014041	regulation of neuron maturation	0.04903679173714133	0.04903679173714133	+1	LRRK2
GO:0014034	neural crest cell fate commitment	0.04903679173714133	0.04903679173714133	+1	SOX9
GO:0010909	positive regulation of heparan sulfate proteoglycan biosynthetic process	0.04903679173714133	0.04903679173714133	+1	CTNNB1
GO:0072434	signal transduction involved in mitotic G2 DNA damage checkpoint	0.04903679173714133	0.04903679173714133	+1	ATM
GO:0010908	regulation of heparan sulfate proteoglycan biosynthetic process	0.04903679173714133	0.04903679173714133	+1	CTNNB1
GO:0072717	cellular response to actinomycin D	0.04903679173714133	0.04903679173714133	+1	TP53
GO:0010767	regulation of transcription from RNA polymerase II promoter in response to UV-induced DNA damage	0.04903679173714133	0.04903679173714133	+1	TAF1
GO:1903971	positive regulation of response to macrophage colony-stimulating factor	0.04903679173714133	0.04903679173714133	+1	TLR4
GO:0090194	negative regulation of glomerulus development	0.04903679173714133	0.04903679173714133	+1	WT1
GO:0097155	fasciculation of sensory neuron axon	0.04903679173714133	0.04903679173714133	+1	EPHA3
GO:0097252	oligodendrocyte apoptotic process	0.04903679173714133	0.04903679173714133	+1	TP53
GO:0097676	histone H3-K36 dimethylation	0.04903679173714133	0.04903679173714133	+1	SETD2
GO:0097681	double-strand break repair via alternative nonhomologous end joining	0.04903679173714133	0.04903679173714133	+1	POLQ
GO:0098693	regulation of synaptic vesicle cycle	0.04903679173714133	0.04903679173714133	+1	PTEN,LRRK2
GO:0009794	regulation of mitotic cell cycle, embryonic	0.04903679173714133	0.04903679173714133	+1	CTNNB1
GO:1902339	positive regulation of apoptotic process involved in morphogenesis	0.04903679173714133	0.04903679173714133	+1	NOTCH1
GO:1902730	positive regulation of proteoglycan biosynthetic process	0.04903679173714133	0.04903679173714133	+1	CTNNB1
GO:1902822	regulation of late endosome to lysosome transport	0.04903679173714133	0.04903679173714133	+1	LRRK2
GO:1903335	regulation of vacuolar transport	0.04903679173714133	0.04903679173714133	+1	LRRK2
GO:0010750	positive regulation of nitric oxide mediated signal transduction	0.04903679173714133	0.04903679173714133	+1	EGFR
GO:0010389	regulation of G2/M transition of mitotic cell cycle	0.04956514701395758	0.04956514701395758	+1	CDKN2A,ATM,CCND1,PPP2R1A
REAC:R-HSA-2219528	PI3K/AKT Signaling in Cancer	4.1159599601469286e-12	4.1159599601469286e-12	+1	PIK3CA,PTEN,EGFR,PIK3R1,AKT1,CDKN1B,HGF,ERBB4,MTOR,KIT,PDGFRA,FGFR2,FGFR3,CDKN1A,PTPN11
REAC:R-HSA-199418	Negative regulation of the PI3K/AKT network	3.255510648758481e-9	3.255510648758481e-9	+1	PIK3CA,PTEN,EGFR,PIK3R1,AKT1,HGF,ERBB4,KIT,PDGFRA,FGFR2,FGFR3,PPP2R1A,PTPN11
REAC:R-HSA-8951936	RUNX3 regulates p14-ARF	1.2439756972225662e-8	1.2439756972225662e-8	+1	KRAS,CDKN2A,RUNX1,EP300,CCND1,CBFB
REAC:R-HSA-6811558	PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling	1.494976707541155e-8	1.494976707541155e-8	+1	PIK3CA,EGFR,PIK3R1,AKT1,HGF,ERBB4,KIT,PDGFRA,FGFR2,FGFR3,PPP2R1A,PTPN11
REAC:R-HSA-2219530	Constitutive Signaling by Aberrant PI3K in Cancer	1.0580277562621162e-7	1.0580277562621162e-7	+1	PIK3CA,EGFR,PIK3R1,HGF,ERBB4,KIT,PDGFRA,FGFR2,FGFR3,PTPN11
REAC:R-HSA-8878159	Transcriptional regulation by RUNX3	1.2401012220923787e-7	1.2401012220923787e-7	+1	TP53,KRAS,CDKN2A,NOTCH1,CTNNB1,RUNX1,EP300,CCND1,SMAD4,CDKN1A,CBFB
REAC:R-HSA-8848021	Signaling by PTK6	1.2401012220923787e-7	1.2401012220923787e-7	+1	KRAS,EGFR,ARHGAP35,NRAS,AKT1,CDKN1B,ERBB4,LRRK2,CCND1
REAC:R-HSA-9006927	Signaling by Non-Receptor Tyrosine Kinases	1.2401012220923787e-7	1.2401012220923787e-7	+1	KRAS,EGFR,ARHGAP35,NRAS,AKT1,CDKN1B,ERBB4,LRRK2,CCND1
REAC:R-HSA-5654741	Signaling by FGFR3	2.0428275355740394e-7	2.0428275355740394e-7	+1	PIK3CA,KRAS,PIK3R1,NRAS,BRAF,FGFR3,PPP2R1A,PTPN11
REAC:R-HSA-112399	IRS-mediated signalling	8.39854910137935e-7	8.39854910137935e-7	+1	PIK3CA,KRAS,PIK3R1,FLT3,NRAS,FGFR2,FGFR3,PTPN11
REAC:R-HSA-8853334	Signaling by FGFR3 fusions in cancer	8.596476712561452e-7	8.596476712561452e-7	+1	PIK3CA,KRAS,PIK3R1,NRAS,FGFR3
REAC:R-HSA-3108232	SUMO E3 ligases SUMOylate target proteins	9.121300482492499e-7	9.121300482492499e-7	+1	TP53,VHL,CDKN2A,DNMT3A,NPM1,STAG2,AR,BRCA1,EP300,SIN3A,SMC1A,SMC3,RAD21
REAC:R-HSA-9018519	Estrogen-dependent gene expression	0.0000010003798848041128	0.0000010003798848041128	+1	GATA3,RUNX1,STAG2,ERBB4,FOXA1,EP300,CCND1,CBFB,HIST1H2BD,SMC1A,SMC3,RAD21
REAC:R-HSA-2990846	SUMOylation	0.0000012318243189043565	0.0000012318243189043565	+1	TP53,VHL,CDKN2A,DNMT3A,NPM1,STAG2,AR,BRCA1,EP300,SIN3A,SMC1A,SMC3,RAD21
REAC:R-HSA-2428928	IRS-related events triggered by IGF1R	0.0000012318243189043565	0.0000012318243189043565	+1	PIK3CA,KRAS,PIK3R1,FLT3,NRAS,FGFR2,FGFR3,PTPN11
REAC:R-HSA-8939211	ESR-mediated signaling	0.0000013131900491741961	0.0000013131900491741961	+1	GATA3,RUNX1,STAG2,ERBB4,FOXA1,EP300,CCND1,CBFB,HIST1H2BD,SMC1A,SMC3,RAD21
REAC:R-HSA-2428924	IGF1R signaling cascade	0.0000013323704890869174	0.0000013323704890869174	+1	PIK3CA,KRAS,PIK3R1,FLT3,NRAS,FGFR2,FGFR3,PTPN11
REAC:R-HSA-6804757	Regulation of TP53 Degradation	0.0000013961759981492299	0.0000013961759981492299	+1	TP53,CDKN2A,AKT1,ATM,MTOR,CHEK2,PPP2R1A
REAC:R-HSA-74751	Insulin receptor signalling cascade	0.0000013961759981492299	0.0000013961759981492299	+1	PIK3CA,KRAS,PIK3R1,FLT3,NRAS,FGFR2,FGFR3,PTPN11
REAC:R-HSA-2404192	Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)	0.0000013961759981492299	0.0000013961759981492299	+1	PIK3CA,KRAS,PIK3R1,FLT3,NRAS,FGFR2,FGFR3,PTPN11
REAC:R-HSA-5633007	Regulation of TP53 Activity	0.000001460247757277049	0.000001460247757277049	+1	TP53,CDKN2A,STK11,AKT1,ATM,MTOR,BRCA1,CHEK2,EP300,TAF1,PPP2R1A,ATR
REAC:R-HSA-6806003	Regulation of TP53 Expression and Degradation	0.0000015913376466568881	0.0000015913376466568881	+1	TP53,CDKN2A,AKT1,ATM,MTOR,CHEK2,PPP2R1A
REAC:R-HSA-5654708	Downstream signaling of activated FGFR3	0.000002840016444811117	0.000002840016444811117	+1	PIK3CA,KRAS,PIK3R1,NRAS,FGFR3,PTPN11
REAC:R-HSA-5654743	Signaling by FGFR4	0.0000029089375230222656	0.0000029089375230222656	+1	PIK3CA,KRAS,PIK3R1,NRAS,BRAF,PPP2R1A,PTPN11
REAC:R-HSA-190236	Signaling by FGFR	0.0000037398796573075883	0.0000037398796573075883	+1	PIK3CA,KRAS,PIK3R1,NRAS,BRAF,FGFR2,FGFR3,PPP2R1A,PTPN11
REAC:R-HSA-69231	Cyclin D associated events in G1	0.000004366461752555905	0.000004366461752555905	+1	CDKN2A,RB1,CDKN1B,CCND1,CDKN1A,PPP2R1A,CDKN2C
REAC:R-HSA-69236	G1 Phase	0.000004366461752555905	0.000004366461752555905	+1	CDKN2A,RB1,CDKN1B,CCND1,CDKN1A,PPP2R1A,CDKN2C
REAC:R-HSA-5637812	Signaling by EGFRvIII in Cancer	0.000004579630314279477	0.000004579630314279477	+1	PIK3CA,KRAS,EGFR,PIK3R1,NRAS
REAC:R-HSA-5637810	Constitutive Signaling by EGFRvIII	0.000004579630314279477	0.000004579630314279477	+1	PIK3CA,KRAS,EGFR,PIK3R1,NRAS
REAC:R-HSA-1236394	Signaling by ERBB4	0.000004779141606137491	0.000004779141606137491	+1	PIK3CA,KRAS,EGFR,PIK3R1,NRAS,ERBB4,NCOR1
REAC:R-HSA-8878166	Transcriptional regulation by RUNX2	0.000005019648003776257	0.000005019648003776257	+1	RB1,FBXW7,RUNX1,AKT1,AR,SOX9,CCND1,SMAD4,CDKN1A,CBFB
REAC:R-HSA-186763	Downstream signal transduction	0.000005649494888974875	0.000005649494888974875	+1	PIK3CA,KRAS,PIK3R1,NRAS,PDGFRA,PTPN11
REAC:R-HSA-5654696	Downstream signaling of activated FGFR2	0.000006859220684944242	0.000006859220684944242	+1	PIK3CA,KRAS,PIK3R1,NRAS,FGFR2,PTPN11
REAC:R-HSA-1227986	Signaling by ERBB2	0.000008887366076336084	0.000008887366076336084	+1	PIK3CA,KRAS,EGFR,PIK3R1,NRAS,AKT1,ERBB4
REAC:R-HSA-5654736	Signaling by FGFR1	0.000008887366076336084	0.000008887366076336084	+1	PIK3CA,KRAS,PIK3R1,NRAS,BRAF,PPP2R1A,PTPN11
REAC:R-HSA-5654738	Signaling by FGFR2	0.000009079209249873824	0.000009079209249873824	+1	PIK3CA,KRAS,PIK3R1,NRAS,BRAF,FGFR2,PPP2R1A,PTPN11
REAC:R-HSA-9006931	Signaling by Nuclear Receptors	0.000009416937864602993	0.000009416937864602993	+1	GATA3,RUNX1,STAG2,ERBB4,FOXA1,EP300,CCND1,CBFB,HIST1H2BD,SMC1A,SMC3,RAD21
REAC:R-HSA-210993	Tie2 Signaling	0.000010352126165358682	0.000010352126165358682	+1	PIK3CA,KRAS,PIK3R1,NRAS,PTPN11
REAC:R-HSA-5673001	RAF/MAP kinase cascade	0.000012960387796900211	0.000012960387796900211	+1	KRAS,EGFR,NF1,FLT3,NRAS,BRAF,HGF,ERBB4,KIT,PDGFRA,FGFR2,FGFR3,PPP2R1A
REAC:R-HSA-1643713	Signaling by EGFR in Cancer	0.000012960387796900211	0.000012960387796900211	+1	PIK3CA,KRAS,EGFR,PIK3R1,NRAS
REAC:R-HSA-5637815	Signaling by Ligand-Responsive EGFR Variants in Cancer	0.000012960387796900211	0.000012960387796900211	+1	PIK3CA,KRAS,EGFR,PIK3R1,NRAS
REAC:R-HSA-1236382	Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants	0.000012960387796900211	0.000012960387796900211	+1	PIK3CA,KRAS,EGFR,PIK3R1,NRAS
REAC:R-HSA-74752	Signaling by Insulin receptor	0.000013366022856948934	0.000013366022856948934	+1	PIK3CA,KRAS,PIK3R1,FLT3,NRAS,FGFR2,FGFR3,PTPN11
REAC:R-HSA-2470946	Cohesin Loading onto Chromatin	0.000023982088602856794	0.000023982088602856794	+1	STAG2,SMC1A,SMC3,RAD21
REAC:R-HSA-5655332	Signaling by FGFR3 in disease	0.000025527803703824787	0.000025527803703824787	+1	PIK3CA,KRAS,PIK3R1,NRAS,FGFR3
REAC:R-HSA-8853338	Signaling by FGFR3 point mutants in cancer	0.000025527803703824787	0.000025527803703824787	+1	PIK3CA,KRAS,PIK3R1,NRAS,FGFR3
REAC:R-HSA-1500620	Meiosis	0.00003251937453193061	0.00003251937453193061	+1	STAG2,ATM,BRCA1,BRCA2,ATR,HIST1H2BD,SMC1A,SMC3,RAD21
REAC:R-HSA-2468052	Establishment of Sister Chromatid Cohesion	0.00003409810540025114	0.00003409810540025114	+1	STAG2,SMC1A,SMC3,RAD21
REAC:R-HSA-180292	GAB1 signalosome	0.00003409810540025114	0.00003409810540025114	+1	PIK3CA,EGFR,PIK3R1,PTPN11
REAC:R-HSA-5655291	Signaling by FGFR4 in disease	0.00003409810540025114	0.00003409810540025114	+1	PIK3CA,KRAS,PIK3R1,NRAS
REAC:R-HSA-2559583	Cellular Senescence	0.00004121595259488347	0.00004121595259488347	+1	TP53,CDKN2A,RB1,MAP2K4,ATM,CDKN1B,HIST1H1C,CDKN1A,HIST1H2BD,CDKN2C,EZH2
REAC:R-HSA-177929	Signaling by EGFR	0.00004230243021716565	0.00004230243021716565	+1	PIK3CA,KRAS,EGFR,PIK3R1,NRAS,PTPN11
REAC:R-HSA-1433557	Signaling by SCF-KIT	0.00004230243021716565	0.00004230243021716565	+1	PIK3CA,KRAS,PIK3R1,NRAS,KIT,PTPN11
REAC:R-HSA-6802953	RAS signaling downstream of NF1 loss-of-function variants	0.00004230243021716565	0.00004230243021716565	+1	KRAS,NF1,NRAS
REAC:R-HSA-9006335	Signaling by Erythropoietin	0.00004349889874705468	0.00004349889874705468	+1	PIK3CA,KRAS,PIK3R1,NRAS,PIK3CG
REAC:R-HSA-9006115	Signaling by NTRK2 (TRKB)	0.00004349889874705468	0.00004349889874705468	+1	PIK3CA,KRAS,PIK3R1,NRAS,PTPN11
REAC:R-HSA-109704	PI3K Cascade	0.000046622328374749066	0.000046622328374749066	+1	PIK3CA,PIK3R1,FLT3,FGFR2,FGFR3,PTPN11
REAC:R-HSA-157118	Signaling by NOTCH	0.00005949133584679279	0.00005949133584679279	+1	TP53,EGFR,NOTCH1,FBXW7,RUNX1,AKT1,ELF3,EP300,CCND1,HIST1H2BD,TBL1XR1,NCOR1
REAC:R-HSA-5654716	Downstream signaling of activated FGFR4	0.0000625239104224225	0.0000625239104224225	+1	PIK3CA,KRAS,PIK3R1,NRAS,PTPN11
REAC:R-HSA-1502540	Signaling by Activin	0.00006342650755058473	0.00006342650755058473	+1	SMAD4,ACVR1B,ACVR2A,SMAD2
REAC:R-HSA-68884	Mitotic Telophase/Cytokinesis	0.00008700308732481145	0.00008700308732481145	+1	STAG2,SMC1A,SMC3,RAD21
REAC:R-HSA-8939247	RUNX1 regulates transcription of genes involved in interleukin signaling	0.0000944906827137966	0.0000944906827137966	+1	RUNX1,CBFB,LIFR
REAC:R-HSA-5654687	Downstream signaling of activated FGFR1	0.00011972353805331264	0.00011972353805331264	+1	PIK3CA,KRAS,PIK3R1,NRAS,PTPN11
REAC:R-HSA-1221632	Meiotic synapsis	0.0001226995990528005	0.0001226995990528005	+1	STAG2,BRCA1,ATR,HIST1H2BD,SMC1A,SMC3,RAD21
REAC:R-HSA-1474165	Reproduction	0.0001273277325046998	0.0001273277325046998	+1	STAG2,ATM,BRCA1,BRCA2,ATR,HIST1H2BD,SMC1A,SMC3,RAD21
REAC:R-HSA-2559586	DNA Damage/Telomere Stress Induced Senescence	0.00013023779226895946	0.00013023779226895946	+1	TP53,RB1,ATM,CDKN1B,HIST1H1C,CDKN1A,HIST1H2BD
REAC:R-HSA-1963640	GRB2 events in ERBB2 signaling	0.0001414552138723511	0.0001414552138723511	+1	KRAS,EGFR,NRAS,ERBB4
REAC:R-HSA-1963642	PI3K events in ERBB2 signaling	0.0001414552138723511	0.0001414552138723511	+1	PIK3CA,EGFR,PIK3R1,ERBB4
REAC:R-HSA-8851907	MET activates PI3K/AKT signaling	0.0001705566896063726	0.0001705566896063726	+1	PIK3CA,PIK3R1,HGF
REAC:R-HSA-8934593	Regulation of RUNX1 Expression and Activity	0.00017549842435435483	0.00017549842435435483	+1	RUNX1,CCND1,CBFB,PTPN11
REAC:R-HSA-9034015	Signaling by NTRK3 (TRKC)	0.00017549842435435483	0.00017549842435435483	+1	PIK3CA,KRAS,PIK3R1,NRAS
REAC:R-HSA-2559584	Formation of Senescence-Associated Heterochromatin Foci (SAHF)	0.00017549842435435483	0.00017549842435435483	+1	TP53,RB1,HIST1H1C,CDKN1A
REAC:R-HSA-186797	Signaling by PDGF	0.00019471293629363758	0.00019471293629363758	+1	PIK3CA,KRAS,PIK3R1,NRAS,PDGFRA,PTPN11
REAC:R-HSA-8878171	Transcriptional regulation by RUNX1	0.00021045083491608702	0.00021045083491608702	+1	ARID1A,PBRM1,GATA3,RUNX1,EP300,CCND1,CBFB,SIN3A,HIST1H2BD,PTPN11,LIFR
REAC:R-HSA-5654710	PI-3K cascade:FGFR3	0.0002167718604448154	0.0002167718604448154	+1	PIK3CA,PIK3R1,FGFR3,PTPN11
REAC:R-HSA-8939243	RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known	0.0002528445797831179	0.0002528445797831179	+1	ARID1A,PBRM1,RUNX1,EP300,CBFB
REAC:R-HSA-69242	S Phase	0.000257069065027334	0.000257069065027334	+1	RB1,AKT1,STAG2,CDKN1B,CCND1,CDKN1A,SMC1A,SMC3,RAD21
REAC:R-HSA-179812	GRB2 events in EGFR signaling	0.0002581736284410207	0.0002581736284410207	+1	KRAS,EGFR,NRAS
REAC:R-HSA-3304349	Loss of Function of SMAD2/3 in Cancer	0.0002581736284410207	0.0002581736284410207	+1	SMAD4,TGFBR2,SMAD2
REAC:R-HSA-3315487	SMAD2/3 MH2 Domain Mutants in Cancer	0.0002581736284410207	0.0002581736284410207	+1	SMAD4,TGFBR2,SMAD2
REAC:R-HSA-8941855	RUNX3 regulates CDKN1A transcription	0.0002581736284410207	0.0002581736284410207	+1	TP53,SMAD4,CDKN1A
REAC:R-HSA-6804760	Regulation of TP53 Activity through Methylation	0.0002581736284410207	0.0002581736284410207	+1	TP53,ATM,CHEK2,EP300
REAC:R-HSA-6804756	Regulation of TP53 Activity through Phosphorylation	0.0002688444402662165	0.0002688444402662165	+1	TP53,STK11,ATM,BRCA1,CHEK2,TAF1,ATR
REAC:R-HSA-8864260	Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors	0.0002688444402662165	0.0002688444402662165	+1	EGFR,NPM1,KIT,EP300,CDKN1A
REAC:R-HSA-1226099	Signaling by FGFR in disease	0.00027775782030232856	0.00027775782030232856	+1	PIK3CA,KRAS,PIK3R1,NRAS,FGFR2,FGFR3
REAC:R-HSA-5693532	DNA Double-Strand Break Repair	0.0002969376194057407	0.0002969376194057407	+1	TP53,BAP1,ATM,BRCA1,POLQ,CHEK2,BRCA2,ATR,HIST1H2BD
REAC:R-HSA-5654706	FRS-mediated FGFR3 signaling	0.0002969376194057407	0.0002969376194057407	+1	KRAS,NRAS,FGFR3,PTPN11
REAC:R-HSA-1181150	Signaling by NODAL	0.0002969376194057407	0.0002969376194057407	+1	SMAD4,ACVR1B,ACVR2A,SMAD2
REAC:R-HSA-6796648	TP53 Regulates Transcription of DNA Repair Genes	0.000319970945238822	0.000319970945238822	+1	TP53,ATM,BRCA1,ATR,CDK12,ERCC2
REAC:R-HSA-69580	p53-Dependent G1/S DNA damage checkpoint	0.0003428037231556236	0.0003428037231556236	+1	TP53,CDKN2A,ATM,CDKN1B,CHEK2,CDKN1A
REAC:R-HSA-69563	p53-Dependent G1 DNA Damage Response	0.0003428037231556236	0.0003428037231556236	+1	TP53,CDKN2A,ATM,CDKN1B,CHEK2,CDKN1A
REAC:R-HSA-4420097	VEGFA-VEGFR2 Pathway	0.000351249256491048	0.000351249256491048	+1	PIK3CA,KRAS,PIK3R1,CTNNB1,NRAS,AKT1,MTOR
REAC:R-HSA-3304351	Signaling by TGF-beta Receptor Complex in Cancer	0.0003665387382728906	0.0003665387382728906	+1	SMAD4,TGFBR2,SMAD2
REAC:R-HSA-180336	SHC1 events in EGFR signaling	0.0003665387382728906	0.0003665387382728906	+1	KRAS,EGFR,NRAS
REAC:R-HSA-3769402	Deactivation of the beta-catenin transactivating complex	0.00038847407405634345	0.00038847407405634345	+1	APC,CTNNB1,AKT1,SOX9,SOX17
REAC:R-HSA-166520	Signaling by NTRKs	0.00038847407405634345	0.00038847407405634345	+1	PIK3CA,KRAS,PIK3R1,NRAS,BRAF,PPP2R1A,PTPN11
REAC:R-HSA-69615	G1/S DNA Damage Checkpoints	0.00038847407405634345	0.00038847407405634345	+1	TP53,CDKN2A,ATM,CDKN1B,CHEK2,CDKN1A
REAC:R-HSA-389357	CD28 dependent PI3K/Akt signaling	0.00040034722728982667	0.00040034722728982667	+1	PIK3CA,PIK3R1,AKT1,MTOR
REAC:R-HSA-1250196	SHC1 events in ERBB2 signaling	0.00040034722728982667	0.00040034722728982667	+1	KRAS,EGFR,NRAS,ERBB4
REAC:R-HSA-5655253	Signaling by FGFR2 in disease	0.000421598101345684	0.000421598101345684	+1	PIK3CA,KRAS,PIK3R1,NRAS,FGFR2
REAC:R-HSA-388841	Costimulation by the CD28 family	0.00043550217682471697	0.00043550217682471697	+1	PIK3CA,PIK3R1,AKT1,MTOR,PPP2R1A,PTPN11
REAC:R-HSA-9006936	Signaling by TGF-beta family members	0.0004411228003392667	0.0004411228003392667	+1	SMAD4,USP9X,TGFBR2,ACVR1B,ACVR2A,NCOR1,SMAD2
REAC:R-HSA-5654695	PI-3K cascade:FGFR2	0.00045400326406008556	0.00045400326406008556	+1	PIK3CA,PIK3R1,FGFR2,PTPN11
REAC:R-HSA-2173795	Downregulation of SMAD2/3:SMAD4 transcriptional activity	0.00045400326406008556	0.00045400326406008556	+1	SMAD4,USP9X,NCOR1,SMAD2
REAC:R-HSA-5689880	Ub-specific processing proteases	0.00045400326406008556	0.00045400326406008556	+1	TP53,PTEN,GATA3,KEAP1,AR,SMAD4,USP9X,HIST1H2BD,SMAD2,AXIN2
REAC:R-HSA-2179392	EGFR Transactivation by Gastrin	0.00048186570858247237	0.00048186570858247237	+1	KRAS,EGFR,NRAS
REAC:R-HSA-1912408	Pre-NOTCH Transcription and Translation	0.00048186570858247237	0.00048186570858247237	+1	TP53,NOTCH1,RUNX1,ELF3,EP300,CCND1,HIST1H2BD
REAC:R-HSA-194138	Signaling by VEGF	0.0005018113636614963	0.0005018113636614963	+1	PIK3CA,KRAS,PIK3R1,CTNNB1,NRAS,AKT1,MTOR
REAC:R-HSA-2122947	NOTCH1 Intracellular Domain Regulates Transcription	0.0006009044016831967	0.0006009044016831967	+1	NOTCH1,FBXW7,EP300,TBL1XR1,NCOR1
REAC:R-HSA-5654700	FRS-mediated FGFR2 signaling	0.0006048552134109147	0.0006048552134109147	+1	KRAS,NRAS,FGFR2,PTPN11
REAC:R-HSA-5673000	RAF activation	0.0006048552134109147	0.0006048552134109147	+1	KRAS,NRAS,BRAF,PPP2R1A
REAC:R-HSA-3108214	SUMOylation of DNA damage response and repair proteins	0.0006248668827484737	0.0006248668827484737	+1	CDKN2A,STAG2,BRCA1,SMC1A,SMC3,RAD21
REAC:R-HSA-5693565	Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks	0.0006248668827484737	0.0006248668827484737	+1	TP53,BAP1,ATM,BRCA1,CHEK2,HIST1H2BD
REAC:R-HSA-1250342	PI3K events in ERBB4 signaling	0.0006454350756875189	0.0006454350756875189	+1	PIK3CA,PIK3R1,ERBB4
REAC:R-HSA-212165	Epigenetic regulation of gene expression	0.0006454350756875189	0.0006454350756875189	+1	DNMT3A,TET2,EP300,SF3B1,SIN3A,HIST1H2BD,ERCC2,EZH2
REAC:R-HSA-5693606	DNA Double Strand Break Response	0.0006575360115329917	0.0006575360115329917	+1	TP53,BAP1,ATM,BRCA1,CHEK2,HIST1H2BD
REAC:R-HSA-453279	Mitotic G1-G1/S phases	0.0006619005132458553	0.0006619005132458553	+1	CDKN2A,RB1,AKT1,CDKN1B,CCND1,CDKN1A,PPP2R1A,CDKN2C
REAC:R-HSA-6785807	Interleukin-4 and Interleukin-13 signaling	0.0006619005132458553	0.0006619005132458553	+1	TP53,PIK3R1,GATA3,AKT1,HGF,CCND1,CDKN1A
REAC:R-HSA-5674400	Constitutive Signaling by AKT1 E17K in Cancer	0.0006688465417083732	0.0006688465417083732	+1	AKT1,CDKN1B,MTOR,CDKN1A
REAC:R-HSA-6791312	TP53 Regulates Transcription of Cell Cycle Genes	0.0006779569316104288	0.0006779569316104288	+1	TP53,NPM1,CDKN1B,EP300,CDKN1A
REAC:R-HSA-187037	Signaling by NTRK1 (TRKA)	0.0006817571294006922	0.0006817571294006922	+1	PIK3CA,KRAS,PIK3R1,NRAS,BRAF,PPP2R1A
REAC:R-HSA-6806834	Signaling by MET	0.0007267791050185524	0.0007267791050185524	+1	PIK3CA,KRAS,PIK3R1,NRAS,HGF,PTPN11
REAC:R-HSA-8851805	MET activates RAS signaling	0.0008235110503753978	0.0008235110503753978	+1	KRAS,NRAS,HGF
REAC:R-HSA-9028731	Activated NTRK2 signals through FRS2 and FRS3	0.0008235110503753978	0.0008235110503753978	+1	KRAS,NRAS,PTPN11
REAC:R-HSA-2424491	DAP12 signaling	0.0008650554826928913	0.0008650554826928913	+1	PIK3CA,KRAS,PIK3R1,NRAS
REAC:R-HSA-5654732	Negative regulation of FGFR3 signaling	0.0009890507174757231	0.0009890507174757231	+1	BRAF,FGFR3,PPP2R1A,PTPN11
REAC:R-HSA-1912422	Pre-NOTCH Expression and Processing	0.0010121468852844608	0.0010121468852844608	+1	TP53,NOTCH1,RUNX1,ELF3,EP300,CCND1,HIST1H2BD
REAC:R-HSA-9027276	Erythropoietin activates Phosphoinositide-3-kinase (PI3K)	0.0010608165438031152	0.0010608165438031152	+1	PIK3CA,PIK3R1,PIK3CG
REAC:R-HSA-5619507	Activation of HOX genes during differentiation	0.0010990732018904155	0.0010990732018904155	+1	CTCF,KDM6A,AJUBA,EP300,HIST1H2BD,NCOR1,EZH2
REAC:R-HSA-5617472	Activation of anterior HOX genes in hindbrain development during early embryogenesis	0.0010990732018904155	0.0010990732018904155	+1	CTCF,KDM6A,AJUBA,EP300,HIST1H2BD,NCOR1,EZH2
REAC:R-HSA-8941326	RUNX2 regulates bone development	0.0012479665173334596	0.0012479665173334596	+1	RB1,AR,SMAD4,CBFB
REAC:R-HSA-9005895	Pervasive developmental disorders	0.0013246492484284367	0.0013246492484284367	+1	SIN3A,TBL1XR1,NCOR1
REAC:R-HSA-9005891	Loss of function of MECP2 in Rett syndrome	0.0013246492484284367	0.0013246492484284367	+1	SIN3A,TBL1XR1,NCOR1
REAC:R-HSA-2894858	Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer	0.0013458542019981225	0.0013458542019981225	+1	NOTCH1,FBXW7,EP300,TBL1XR1,NCOR1
REAC:R-HSA-2644602	Signaling by NOTCH1 PEST Domain Mutants in Cancer	0.0013458542019981225	0.0013458542019981225	+1	NOTCH1,FBXW7,EP300,TBL1XR1,NCOR1
REAC:R-HSA-2644606	Constitutive Signaling by NOTCH1 PEST Domain Mutants	0.0013458542019981225	0.0013458542019981225	+1	NOTCH1,FBXW7,EP300,TBL1XR1,NCOR1
REAC:R-HSA-2644603	Signaling by NOTCH1 in Cancer	0.0013458542019981225	0.0013458542019981225	+1	NOTCH1,FBXW7,EP300,TBL1XR1,NCOR1
REAC:R-HSA-2894862	Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants	0.0013458542019981225	0.0013458542019981225	+1	NOTCH1,FBXW7,EP300,TBL1XR1,NCOR1
REAC:R-HSA-3311021	SMAD4 MH2 Domain Mutants in Cancer	0.0014458729016835954	0.0014458729016835954	+1	SMAD4,SMAD2
REAC:R-HSA-8951911	RUNX3 regulates RUNX1-mediated transcription	0.0014458729016835954	0.0014458729016835954	+1	RUNX1,CBFB
REAC:R-HSA-3304347	Loss of Function of SMAD4 in Cancer	0.0014458729016835954	0.0014458729016835954	+1	SMAD4,SMAD2
REAC:R-HSA-389356	CD28 co-stimulation	0.0014905106676110608	0.0014905106676110608	+1	PIK3CA,PIK3R1,AKT1,MTOR
REAC:R-HSA-6804116	TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest	0.001543453482806608	0.001543453482806608	+1	TP53,CDKN1B,CDKN1A
REAC:R-HSA-8849471	PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases	0.001543453482806608	0.001543453482806608	+1	KRAS,ARHGAP35,NRAS
REAC:R-HSA-1250347	SHC1 events in ERBB4 signaling	0.001543453482806608	0.001543453482806608	+1	KRAS,NRAS,ERBB4
REAC:R-HSA-198323	AKT phosphorylates targets in the cytosol	0.001543453482806608	0.001543453482806608	+1	AKT1,CDKN1B,CDKN1A
REAC:R-HSA-5654727	Negative regulation of FGFR2 signaling	0.0016073738235459043	0.0016073738235459043	+1	BRAF,FGFR2,PPP2R1A,PTPN11
REAC:R-HSA-2559585	Oncogene Induced Senescence	0.0016073738235459043	0.0016073738235459043	+1	TP53,CDKN2A,RB1,CDKN2C
REAC:R-HSA-8943724	Regulation of PTEN gene transcription	0.0016073738235459043	0.0016073738235459043	+1	TP53,PTEN,MTOR,MECOM,EZH2
REAC:R-HSA-69473	G2/M DNA damage checkpoint	0.0016716406384893196	0.0016716406384893196	+1	TP53,ATM,BRCA1,CHEK2,ATR,HIST1H2BD
REAC:R-HSA-114604	GPVI-mediated activation cascade	0.0017800411998872305	0.0017800411998872305	+1	PIK3CA,PIK3R1,PIK3CG,PTPN11
REAC:R-HSA-5339716	Misspliced GSK3beta mutants stabilize beta-catenin	0.0017869869575308308	0.0017869869575308308	+1	APC,CTNNB1,PPP2R1A
REAC:R-HSA-4839743	phosphorylation site mutants of CTNNB1 are not targeted to the proteasome by the destruction complex	0.0017869869575308308	0.0017869869575308308	+1	APC,CTNNB1,PPP2R1A
REAC:R-HSA-5358751	S45 mutants of beta-catenin aren't phosphorylated	0.0017869869575308308	0.0017869869575308308	+1	APC,CTNNB1,PPP2R1A
REAC:R-HSA-5358749	S37 mutants of beta-catenin aren't phosphorylated	0.0017869869575308308	0.0017869869575308308	+1	APC,CTNNB1,PPP2R1A
REAC:R-HSA-5358752	T41 mutants of beta-catenin aren't phosphorylated	0.0017869869575308308	0.0017869869575308308	+1	APC,CTNNB1,PPP2R1A
REAC:R-HSA-8986944	Transcriptional Regulation by MECP2	0.0017869869575308308	0.0017869869575308308	+1	PTEN,NOTCH1,SIN3A,TBL1XR1,NCOR1
REAC:R-HSA-5358747	S33 mutants of beta-catenin aren't phosphorylated	0.0017869869575308308	0.0017869869575308308	+1	APC,CTNNB1,PPP2R1A
REAC:R-HSA-2172127	DAP12 interactions	0.0018990033866498376	0.0018990033866498376	+1	PIK3CA,KRAS,PIK3R1,NRAS
REAC:R-HSA-1295596	Spry regulation of FGF signaling	0.002159375620717224	0.002159375620717224	+1	BRAF,PPP2R1A,PTPN11
REAC:R-HSA-5655302	Signaling by FGFR1 in disease	0.002305243025757108	0.002305243025757108	+1	PIK3CA,KRAS,PIK3R1,NRAS
REAC:R-HSA-201681	TCF dependent signaling in response to WNT	0.002305243025757108	0.002305243025757108	+1	APC,CTNNB1,AKT1,SOX9,EP300,SOX17,PPP2R1A,HIST1H2BD,AXIN2
REAC:R-HSA-69560	Transcriptional activation of p53 responsive genes  	0.002494667360909478	0.002494667360909478	+1	TP53,CDKN1A
REAC:R-HSA-69895	Transcriptional  activation of  cell cycle inhibitor p21 	0.002494667360909478	0.002494667360909478	+1	TP53,CDKN1A
REAC:R-HSA-8941333	RUNX2 regulates genes involved in differentiation of myeloid cells	0.002494667360909478	0.002494667360909478	+1	RUNX1,CBFB
REAC:R-HSA-5693616	Presynaptic phase of homologous DNA pairing and strand exchange	0.002494667360909478	0.002494667360909478	+1	ATM,BRCA1,BRCA2,ATR
REAC:R-HSA-196299	Beta-catenin phosphorylation cascade	0.0025062643294445856	0.0025062643294445856	+1	APC,CTNNB1,PPP2R1A
REAC:R-HSA-5675221	Negative regulation of MAPK pathway	0.0026932033679162967	0.0026932033679162967	+1	KRAS,NRAS,BRAF,PPP2R1A
REAC:R-HSA-881907	Gastrin-CREB signalling pathway via PKC and MAPK	0.002893494441991428	0.002893494441991428	+1	KRAS,EGFR,NRAS
REAC:R-HSA-5654704	SHC-mediated cascade:FGFR3	0.002893494441991428	0.002893494441991428	+1	KRAS,NRAS,FGFR3
REAC:R-HSA-170834	Signaling by TGF-beta Receptor Complex	0.0031489876038116745	0.0031489876038116745	+1	SMAD4,USP9X,TGFBR2,NCOR1,SMAD2
REAC:R-HSA-5693579	Homologous DNA Pairing and Strand Exchange	0.0031489876038116745	0.0031489876038116745	+1	ATM,BRCA1,BRCA2,ATR
REAC:R-HSA-1980143	Signaling by NOTCH1	0.0031489876038116745	0.0031489876038116745	+1	NOTCH1,FBXW7,EP300,TBL1XR1,NCOR1
REAC:R-HSA-186712	Regulation of beta-cell development	0.0031489876038116745	0.0031489876038116745	+1	NOTCH1,AKT1,EP300,FOXA2
REAC:R-HSA-2173793	Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer	0.0037244818251975027	0.0037244818251975027	+1	SMAD4,USP9X,NCOR1,SMAD2
REAC:R-HSA-8935964	RUNX1 regulates expression of components of tight junctions	0.00375225835866992	0.00375225835866992	+1	RUNX1,CBFB
REAC:R-HSA-8865999	MET activates PTPN11	0.00375225835866992	0.00375225835866992	+1	HGF,PTPN11
REAC:R-HSA-3134973	LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production	0.00375225835866992	0.00375225835866992	+1	CTNNB1,EP300
REAC:R-HSA-2644605	FBXW7 Mutants and NOTCH1 in Cancer	0.00375225835866992	0.00375225835866992	+1	NOTCH1,FBXW7
REAC:R-HSA-1169092	Activation of RAS in B cells	0.00375225835866992	0.00375225835866992	+1	KRAS,NRAS
REAC:R-HSA-5654720	PI-3K cascade:FGFR4	0.00375225835866992	0.00375225835866992	+1	PIK3CA,PIK3R1,PTPN11
REAC:R-HSA-2644607	Loss of Function of FBXW7 in Cancer and NOTCH1 Signaling	0.00375225835866992	0.00375225835866992	+1	NOTCH1,FBXW7
REAC:R-HSA-389513	CTLA4 inhibitory signaling	0.004283738275407165	0.004283738275407165	+1	AKT1,PPP2R1A,PTPN11
REAC:R-HSA-5621575	CD209 (DC-SIGN) signaling	0.004283738275407165	0.004283738275407165	+1	KRAS,NRAS,EP300
REAC:R-HSA-5654689	PI-3K cascade:FGFR1	0.004283738275407165	0.004283738275407165	+1	PIK3CA,PIK3R1,PTPN11
REAC:R-HSA-5654712	FRS-mediated FGFR4 signaling	0.004900978865128207	0.004900978865128207	+1	KRAS,NRAS,PTPN11
REAC:R-HSA-3304356	SMAD2/3 Phosphorylation Motif Mutants in Cancer	0.005268251669563471	0.005268251669563471	+1	TGFBR2,SMAD2
REAC:R-HSA-69202	Cyclin E associated events during G1/S transition 	0.005268251669563471	0.005268251669563471	+1	RB1,AKT1,CDKN1B,CCND1,CDKN1A
REAC:R-HSA-8857538	PTK6 promotes HIF1A stabilization	0.005268251669563471	0.005268251669563471	+1	EGFR,LRRK2
REAC:R-HSA-9603381	Activated NTRK3 signals through PI3K	0.005268251669563471	0.005268251669563471	+1	PIK3CA,PIK3R1
REAC:R-HSA-8931987	RUNX1 regulates estrogen receptor mediated transcription	0.005268251669563471	0.005268251669563471	+1	RUNX1,CBFB
REAC:R-HSA-8939245	RUNX1 regulates transcription of genes involved in BCR signaling	0.005268251669563471	0.005268251669563471	+1	RUNX1,CBFB
REAC:R-HSA-8849470	PTK6 Regulates Cell Cycle	0.005268251669563471	0.005268251669563471	+1	CDKN1B,CCND1
REAC:R-HSA-8939256	RUNX1 regulates transcription of genes involved in WNT signaling	0.005268251669563471	0.005268251669563471	+1	RUNX1,CBFB
REAC:R-HSA-5654693	FRS-mediated FGFR1 signaling	0.005317076175236816	0.005317076175236816	+1	KRAS,NRAS,PTPN11
REAC:R-HSA-5654699	SHC-mediated cascade:FGFR2	0.005317076175236816	0.005317076175236816	+1	KRAS,NRAS,FGFR2
REAC:R-HSA-109581	Apoptosis	0.005317076175236816	0.005317076175236816	+1	TP53,APC,CTNNB1,CDH1,AKT1,TLR4,HIST1H1C
REAC:R-HSA-2559580	Oxidative Stress Induced Senescence	0.005467885461413267	0.005467885461413267	+1	TP53,CDKN2A,MAP2K4,HIST1H2BD,CDKN2C,EZH2
REAC:R-HSA-69656	Cyclin A:Cdk2-associated events at S phase entry	0.005557858519368229	0.005557858519368229	+1	RB1,AKT1,CDKN1B,CCND1,CDKN1A
REAC:R-HSA-5357801	Programmed Cell Death	0.005762584250256907	0.005762584250256907	+1	TP53,APC,CTNNB1,CDH1,AKT1,TLR4,HIST1H1C
REAC:R-HSA-8940973	RUNX2 regulates osteoblast differentiation	0.005925720193520325	0.005925720193520325	+1	RB1,AR,CBFB
REAC:R-HSA-75153	Apoptotic execution phase	0.006154367685124481	0.006154367685124481	+1	APC,CTNNB1,CDH1,HIST1H1C
REAC:R-HSA-1660499	Synthesis of PIPs at the plasma membrane	0.006548463267542703	0.006548463267542703	+1	PIK3CA,PTEN,PIK3R1,PIK3CG
REAC:R-HSA-6802949	Signaling by RAS mutants	0.006548463267542703	0.006548463267542703	+1	KRAS,NF1,NRAS,BRAF
REAC:R-HSA-69206	G1/S Transition	0.006732636019677221	0.006732636019677221	+1	RB1,AKT1,CDKN1B,CCND1,CDKN1A,PPP2R1A
REAC:R-HSA-112412	SOS-mediated signalling	0.0067976178509010915	0.0067976178509010915	+1	KRAS,NRAS
REAC:R-HSA-8939246	RUNX1 regulates transcription of genes involved in differentiation of myeloid cells	0.0067976178509010915	0.0067976178509010915	+1	RUNX1,CBFB
REAC:R-HSA-9022537	Loss of MECP2 binding ability to the NCoR/SMRT complex	0.0067976178509010915	0.0067976178509010915	+1	TBL1XR1,NCOR1
REAC:R-HSA-3656534	Loss of Function of TGFBR1 in Cancer	0.0067976178509010915	0.0067976178509010915	+1	TGFBR2,SMAD2
REAC:R-HSA-9028335	Activated NTRK2 signals through PI3K	0.0067976178509010915	0.0067976178509010915	+1	PIK3CA,PIK3R1
REAC:R-HSA-3656532	TGFBR1 KD Mutants in Cancer	0.0067976178509010915	0.0067976178509010915	+1	TGFBR2,SMAD2
REAC:R-HSA-5693554	Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA)	0.0071533868742855574	0.0071533868742855574	+1	ATM,BRCA1,BRCA2
REAC:R-HSA-5218920	VEGFR2 mediated vascular permeability	0.007956069368449602	0.007956069368449602	+1	CTNNB1,AKT1,MTOR
REAC:R-HSA-69541	Stabilization of p53	0.008209501482040932	0.008209501482040932	+1	TP53,CDKN2A,ATM,CHEK2
REAC:R-HSA-5693538	Homology Directed Repair	0.008387719609454536	0.008387719609454536	+1	ATM,BRCA1,POLQ,BRCA2,ATR,HIST1H2BD
REAC:R-HSA-6807070	PTEN Regulation	0.008637199867241062	0.008637199867241062	+1	TP53,PTEN,AKT1,MTOR,MECOM,EZH2
REAC:R-HSA-9034864	Activated NTRK3 signals through RAS	0.008637199867241062	0.008637199867241062	+1	KRAS,NRAS
REAC:R-HSA-8939242	RUNX1 regulates transcription of genes involved in differentiation of keratinocytes	0.008637199867241062	0.008637199867241062	+1	RUNX1,CBFB
REAC:R-HSA-4411364	Binding of TCF/LEF:CTNNB1 to target gene promoters	0.008637199867241062	0.008637199867241062	+1	CTNNB1,AXIN2
REAC:R-HSA-8941332	RUNX2 regulates genes involved in cell migration	0.008637199867241062	0.008637199867241062	+1	AKT1,CBFB
REAC:R-HSA-8951430	RUNX3 regulates WNT signaling	0.008637199867241062	0.008637199867241062	+1	CTNNB1,CCND1
REAC:R-HSA-8863795	Downregulation of ERBB2 signaling	0.009400221704394751	0.009400221704394751	+1	EGFR,AKT1,ERBB4
REAC:R-HSA-8936459	RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function	0.009400221704394751	0.009400221704394751	+1	RUNX1,EP300,CBFB,SIN3A,HIST1H2BD
REAC:R-HSA-187687	Signalling to ERKs	0.010286508787809135	0.010286508787809135	+1	KRAS,NRAS,BRAF
REAC:R-HSA-6804758	Regulation of TP53 Activity through Acetylation	0.010286508787809135	0.010286508787809135	+1	TP53,AKT1,EP300
REAC:R-HSA-6811555	PI5P Regulates TP53 Acetylation	0.010642108034797206	0.010642108034797206	+1	TP53,EP300
REAC:R-HSA-2428933	SHC-related events triggered by IGF1R	0.010642108034797206	0.010642108034797206	+1	KRAS,NRAS
REAC:R-HSA-8876493	InlA-mediated entry of Listeria monocytogenes into host cells	0.010642108034797206	0.010642108034797206	+1	CTNNB1,CDH1
REAC:R-HSA-9026519	Activated NTRK2 signals through RAS	0.010642108034797206	0.010642108034797206	+1	KRAS,NRAS
REAC:R-HSA-198203	PI3K/AKT activation	0.010642108034797206	0.010642108034797206	+1	PIK3CA,PIK3R1
REAC:R-HSA-5654733	Negative regulation of FGFR4 signaling	0.01099783602137204	0.01099783602137204	+1	BRAF,PPP2R1A,PTPN11
REAC:R-HSA-4641262	Disassembly of the destruction complex and recruitment of AXIN to the membrane	0.01099783602137204	0.01099783602137204	+1	APC,CTNNB1,PPP2R1A
REAC:R-HSA-2173789	TGF-beta receptor signaling activates SMADs	0.01195520598634558	0.01195520598634558	+1	SMAD4,TGFBR2,SMAD2
REAC:R-HSA-9022692	Regulation of MECP2 expression and activity	0.01195520598634558	0.01195520598634558	+1	SIN3A,TBL1XR1,NCOR1
REAC:R-HSA-8877330	RUNX1 and FOXP3 control the development of regulatory T lymphocytes (Tregs)	0.012906483276026103	0.012906483276026103	+1	RUNX1,CBFB
REAC:R-HSA-5654726	Negative regulation of FGFR1 signaling	0.012906483276026103	0.012906483276026103	+1	BRAF,PPP2R1A,PTPN11
REAC:R-HSA-5693568	Resolution of D-loop Structures through Holliday Junction Intermediates	0.012906483276026103	0.012906483276026103	+1	ATM,BRCA1,BRCA2
REAC:R-HSA-5685942	HDR through Homologous Recombination (HRR)	0.013415279877010706	0.013415279877010706	+1	ATM,BRCA1,BRCA2,ATR
REAC:R-HSA-5693537	Resolution of D-Loop Structures	0.013894473599883567	0.013894473599883567	+1	ATM,BRCA1,BRCA2
REAC:R-HSA-4791275	Signaling by WNT in cancer	0.013894473599883567	0.013894473599883567	+1	APC,CTNNB1,PPP2R1A
REAC:R-HSA-2559582	Senescence-Associated Secretory Phenotype (SASP)	0.014356334113954138	0.014356334113954138	+1	CDKN2A,CDKN1B,CDKN1A,HIST1H2BD,CDKN2C
REAC:R-HSA-1433617	Regulation of signaling by NODAL	0.015267659966265557	0.015267659966265557	+1	ACVR1B,ACVR2A
REAC:R-HSA-351906	Apoptotic cleavage of cell adhesion  proteins	0.015267659966265557	0.015267659966265557	+1	CTNNB1,CDH1
REAC:R-HSA-6802948	Signaling by high-kinase activity BRAF mutants	0.016070283664723916	0.016070283664723916	+1	KRAS,NRAS,BRAF
REAC:R-HSA-3214841	PKMTs methylate histone lysines	0.016070283664723916	0.016070283664723916	+1	SETD2,NSD1,MECOM,EZH2
REAC:R-HSA-5685938	HDR through Single Strand Annealing (SSA)	0.01720107878063642	0.01720107878063642	+1	ATM,BRCA1,ATR
REAC:R-HSA-6803207	TP53 Regulates Transcription of Caspase Activators and Caspases	0.01786818353009612	0.01786818353009612	+1	TP53,ATM
REAC:R-HSA-5689896	Ovarian tumor domain proteases	0.01833901260290441	0.01833901260290441	+1	TP53,PTEN,APC
REAC:R-HSA-111465	Apoptotic cleavage of cellular proteins	0.01833901260290441	0.01833901260290441	+1	APC,CTNNB1,CDH1
REAC:R-HSA-69481	G2/M Checkpoints	0.019072198921673077	0.019072198921673077	+1	TP53,ATM,BRCA1,CHEK2,ATR,HIST1H2BD
REAC:R-HSA-6802957	Oncogenic MAPK signaling	0.01991563339996988	0.01991563339996988	+1	KRAS,NF1,NRAS,BRAF
REAC:R-HSA-8847993	ERBB2 Activates PTK6 Signaling	0.02042700749781457	0.02042700749781457	+1	EGFR,ERBB4
REAC:R-HSA-113501	Inhibition of replication initiation of damaged DNA by RB1/E2F1	0.02042700749781457	0.02042700749781457	+1	RB1,PPP2R1A
REAC:R-HSA-8853659	RET signaling	0.02042700749781457	0.02042700749781457	+1	PIK3CA,PIK3R1,PTPN11
REAC:R-HSA-171007	p38MAPK events	0.02042700749781457	0.02042700749781457	+1	KRAS,NRAS
REAC:R-HSA-165159	mTOR signalling	0.02042700749781457	0.02042700749781457	+1	STK11,AKT1,MTOR
REAC:R-HSA-5674135	MAP2K and MAPK activation	0.02042700749781457	0.02042700749781457	+1	KRAS,NRAS,BRAF
REAC:R-HSA-6802955	Paradoxical activation of RAF signaling by kinase inactive BRAF	0.02042700749781457	0.02042700749781457	+1	KRAS,NRAS,BRAF
REAC:R-HSA-6802946	Signaling by moderate kinase activity BRAF mutants	0.02042700749781457	0.02042700749781457	+1	KRAS,NRAS,BRAF
REAC:R-HSA-3214858	RMTs methylate histone arginines	0.022004568969648072	0.022004568969648072	+1	ARID1A,PBRM1,DNMT3A,CCND1
REAC:R-HSA-8941856	RUNX3 regulates NOTCH signaling	0.022272319707652883	0.022272319707652883	+1	NOTCH1,EP300
REAC:R-HSA-6804759	Regulation of TP53 Activity through Association with Co-factors	0.022272319707652883	0.022272319707652883	+1	TP53,AKT1
REAC:R-HSA-5467340	AXIN missense mutants destabilize the destruction complex	0.022272319707652883	0.022272319707652883	+1	APC,PPP2R1A
REAC:R-HSA-5467337	APC truncation mutants have impaired AXIN binding	0.022272319707652883	0.022272319707652883	+1	APC,PPP2R1A
REAC:R-HSA-2500257	Resolution of Sister Chromatid Cohesion	0.022272319707652883	0.022272319707652883	+1	STAG2,PPP2R1A,SMC1A,SMC3,RAD21
REAC:R-HSA-4839748	AMER1 mutants destabilize the destruction complex	0.022272319707652883	0.022272319707652883	+1	APC,PPP2R1A
REAC:R-HSA-9027284	Erythropoietin activates RAS	0.022272319707652883	0.022272319707652883	+1	KRAS,NRAS
REAC:R-HSA-4839735	AXIN mutants destabilize the destruction complex, activating WNT signaling	0.022272319707652883	0.022272319707652883	+1	APC,PPP2R1A
REAC:R-HSA-4839744	truncated APC mutants destabilize the destruction complex	0.022272319707652883	0.022272319707652883	+1	APC,PPP2R1A
REAC:R-HSA-5467348	Truncations of AMER1 destabilize the destruction complex	0.022272319707652883	0.022272319707652883	+1	APC,PPP2R1A
REAC:R-HSA-3899300	SUMOylation of transcription cofactors	0.023799902173339472	0.023799902173339472	+1	NPM1,EP300,SIN3A
REAC:R-HSA-9013694	Signaling by NOTCH4	0.023874570325394473	0.023874570325394473	+1	NOTCH1,FBXW7,AKT1,EP300
REAC:R-HSA-166016	Toll Like Receptor 4 (TLR4) Cascade	0.023874570325394473	0.023874570325394473	+1	MAP3K1,MAP2K4,TLR4,PPP2R1A,PTPN11
REAC:R-HSA-6785631	ERBB2 Regulates Cell Motility	0.025110403200916353	0.025110403200916353	+1	EGFR,ERBB4
REAC:R-HSA-8866910	TFAP2 (AP-2) family regulates transcription of growth factors and their receptors	0.025110403200916353	0.025110403200916353	+1	EGFR,KIT
REAC:R-HSA-1500931	Cell-Cell communication	0.02513700903071217	0.02513700903071217	+1	PIK3CA,PIK3R1,CTNNB1,CDH1,PTPN11
REAC:R-HSA-1483255	PI Metabolism	0.02543544285268226	0.02543544285268226	+1	PIK3CA,PTEN,PIK3R1,PIK3CG
REAC:R-HSA-381340	Transcriptional regulation of white adipocyte differentiation	0.02543544285268226	0.02543544285268226	+1	CEBPA,EP300,TBL1XR1,NCOR1
REAC:R-HSA-195253	Degradation of beta-catenin by the destruction complex	0.02543544285268226	0.02543544285268226	+1	APC,CTNNB1,PPP2R1A,AXIN2
REAC:R-HSA-2978092	Abnormal conversion of 2-oxoglutarate to 2-hydroxyglutarate	0.02548356482133782	0.02548356482133782	+1	IDH1
REAC:R-HSA-5674404	PTEN Loss of Function in Cancer	0.02548356482133782	0.02548356482133782	+1	PTEN
REAC:R-HSA-2033515	t(4;14) translocations of FGFR3	0.02548356482133782	0.02548356482133782	+1	FGFR3
REAC:R-HSA-389542	NADPH regeneration	0.02548356482133782	0.02548356482133782	+1	IDH1
REAC:R-HSA-5467333	APC truncation mutants are not K63 polyubiquitinated	0.02548356482133782	0.02548356482133782	+1	APC
REAC:R-HSA-8853333	Signaling by FGFR2 fusions	0.02548356482133782	0.02548356482133782	+1	FGFR2
REAC:R-HSA-2023837	Signaling by FGFR2 amplification mutants	0.02548356482133782	0.02548356482133782	+1	FGFR2
REAC:R-HSA-5693567	HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA)	0.02580841645036051	0.02580841645036051	+1	ATM,BRCA1,BRCA2,ATR,HIST1H2BD
REAC:R-HSA-2454202	Fc epsilon receptor (FCERI) signaling	0.026827427616149174	0.026827427616149174	+1	PIK3CA,KRAS,PIK3R1,MAP3K1,NRAS,MAP2K4
REAC:R-HSA-210744	Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells	0.02724949690147565	0.02724949690147565	+1	NOTCH1,EP300
REAC:R-HSA-5628897	TP53 Regulates Metabolic Genes	0.027518997661006593	0.027518997661006593	+1	TP53,PTEN,AKT1,MTOR
REAC:R-HSA-912446	Meiotic recombination	0.027518997661006593	0.027518997661006593	+1	ATM,BRCA1,BRCA2,HIST1H2BD
REAC:R-HSA-2871796	FCERI mediated MAPK activation	0.027518997661006593	0.027518997661006593	+1	KRAS,MAP3K1,NRAS,MAP2K4
REAC:R-HSA-512988	Interleukin-3, Interleukin-5 and GM-CSF signaling	0.02997254234809304	0.02997254234809304	+1	PIK3CA,PIK3R1,PTPN11
REAC:R-HSA-432142	Platelet sensitization by LDL	0.030112203305767277	0.030112203305767277	+1	PPP2R1A,PTPN11
REAC:R-HSA-936964	Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon	0.030112203305767277	0.030112203305767277	+1	TLR4,PTPN11
REAC:R-HSA-9012852	Signaling by NOTCH3	0.03140587948879631	0.03140587948879631	+1	EGFR,NOTCH1,EP300
REAC:R-HSA-975138	TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation	0.031569682538414356	0.031569682538414356	+1	MAP3K1,MAP2K4,TLR4,PPP2R1A
REAC:R-HSA-201722	Formation of the beta-catenin:TCF transactivating complex	0.03245734351639443	0.03245734351639443	+1	CTNNB1,EP300,HIST1H2BD,AXIN2
REAC:R-HSA-975155	MyD88 dependent cascade initiated on endosome	0.03245734351639443	0.03245734351639443	+1	MAP3K1,MAP2K4,TLR4,PPP2R1A
REAC:R-HSA-168181	Toll Like Receptor 7/8 (TLR7/8) Cascade	0.03245734351639443	0.03245734351639443	+1	MAP3K1,MAP2K4,TLR4,PPP2R1A
REAC:R-HSA-1368082	RORA activates gene expression	0.03274313718216284	0.03274313718216284	+1	EP300,TBL1XR1
REAC:R-HSA-9022699	MECP2 regulates neuronal receptors and channels	0.03274313718216284	0.03274313718216284	+1	NOTCH1,SIN3A
REAC:R-HSA-6804114	TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest	0.03274313718216284	0.03274313718216284	+1	TP53,EP300
REAC:R-HSA-1839117	Signaling by cytosolic FGFR1 fusion mutants	0.03274313718216284	0.03274313718216284	+1	PIK3CA,PIK3R1
REAC:R-HSA-3214842	HDMs demethylate histones	0.03404741681499141	0.03404741681499141	+1	KDM6A,KDM5C,ARID5B
REAC:R-HSA-166058	MyD88:MAL(TIRAP) cascade initiated on plasma membrane	0.03416459552764059	0.03416459552764059	+1	MAP3K1,MAP2K4,TLR4,PPP2R1A
REAC:R-HSA-168188	Toll Like Receptor TLR6:TLR2 Cascade	0.03416459552764059	0.03416459552764059	+1	MAP3K1,MAP2K4,TLR4,PPP2R1A
REAC:R-HSA-5218921	VEGFR2 mediated cell proliferation	0.035818980595909156	0.035818980595909156	+1	KRAS,NRAS
REAC:R-HSA-8978934	Metabolism of cofactors	0.035818980595909156	0.035818980595909156	+1	IDH1,AKT1
REAC:R-HSA-168138	Toll Like Receptor 9 (TLR9) Cascade	0.03633676760546304	0.03633676760546304	+1	MAP3K1,MAP2K4,TLR4,PPP2R1A
REAC:R-HSA-6781823	Formation of TC-NER Pre-Incision Complex	0.03708789356733534	0.03708789356733534	+1	CRIPAK,EP300,ERCC2
REAC:R-HSA-181438	Toll Like Receptor 2 (TLR2) Cascade	0.037284773563382785	0.037284773563382785	+1	MAP3K1,MAP2K4,TLR4,PPP2R1A
REAC:R-HSA-168179	Toll Like Receptor TLR1:TLR2 Cascade	0.037284773563382785	0.037284773563382785	+1	MAP3K1,MAP2K4,TLR4,PPP2R1A
REAC:R-HSA-166166	MyD88-independent TLR4 cascade 	0.038070299134151116	0.038070299134151116	+1	MAP2K4,TLR4,PPP2R1A,PTPN11
REAC:R-HSA-9013695	NOTCH4 Intracellular Domain Regulates Transcription	0.038070299134151116	0.038070299134151116	+1	NOTCH1,EP300
REAC:R-HSA-8876384	Listeria monocytogenes entry into host cells	0.038070299134151116	0.038070299134151116	+1	CTNNB1,CDH1
REAC:R-HSA-5693607	Processing of DNA double-strand break ends	0.038070299134151116	0.038070299134151116	+1	ATM,BRCA1,ATR,HIST1H2BD
REAC:R-HSA-5654719	SHC-mediated cascade:FGFR4	0.038070299134151116	0.038070299134151116	+1	KRAS,NRAS
REAC:R-HSA-3232118	SUMOylation of transcription factors	0.038070299134151116	0.038070299134151116	+1	TP53,CDKN2A
REAC:R-HSA-6803204	TP53 Regulates Transcription of Genes Involved in Cytochrome C Release	0.038070299134151116	0.038070299134151116	+1	TP53,ATM
REAC:R-HSA-937061	TRIF(TICAM1)-mediated TLR4 signaling 	0.038070299134151116	0.038070299134151116	+1	MAP2K4,TLR4,PPP2R1A,PTPN11
REAC:R-HSA-167044	Signalling to RAS	0.038070299134151116	0.038070299134151116	+1	KRAS,NRAS
REAC:R-HSA-2151201	Transcriptional activation of mitochondrial biogenesis	0.03943156359976508	0.03943156359976508	+1	IDH2,TBL1XR1,NCOR1
REAC:R-HSA-8941858	Regulation of RUNX3 expression and activity	0.03943156359976508	0.03943156359976508	+1	CDKN2A,EP300,CBFB
REAC:R-HSA-3371556	Cellular response to heat stress	0.03985188491952165	0.03985188491952165	+1	ATM,MTOR,EP300,ATR
REAC:R-HSA-6804115	TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain	0.04098560315716636	0.04098560315716636	+1	TP53,NPM1
REAC:R-HSA-5654688	SHC-mediated cascade:FGFR1	0.04098560315716636	0.04098560315716636	+1	KRAS,NRAS
REAC:R-HSA-210745	Regulation of gene expression in beta cells	0.04098560315716636	0.04098560315716636	+1	AKT1,FOXA2
REAC:R-HSA-168898	Toll-like Receptor Cascades	0.04098560315716636	0.04098560315716636	+1	MAP3K1,MAP2K4,TLR4,PPP2R1A,PTPN11
REAC:R-HSA-113510	E2F mediated regulation of DNA replication	0.04405260121596319	0.04405260121596319	+1	RB1,PPP2R1A
REAC:R-HSA-3642279	TGFBR2 MSI Frameshift Mutants in Cancer	0.04405260121596319	0.04405260121596319	+1	TGFBR2
REAC:R-HSA-5638302	Signaling by Overexpressed Wild-Type EGFR in Cancer	0.04405260121596319	0.04405260121596319	+1	EGFR
REAC:R-HSA-912631	Regulation of signaling by CBL	0.04405260121596319	0.04405260121596319	+1	PIK3CA,PIK3R1
REAC:R-HSA-5638303	Inhibition of Signaling by Overexpressed EGFR	0.04405260121596319	0.04405260121596319	+1	EGFR
REAC:R-HSA-6804754	Regulation of TP53 Expression	0.04405260121596319	0.04405260121596319	+1	TP53
REAC:R-HSA-373753	Nephrin family interactions	0.047603942865555714	0.047603942865555714	+1	PIK3CA,PIK3R1
REAC:R-HSA-187577	SCF(Skp2)-mediated degradation of p27/p21	0.047603942865555714	0.047603942865555714	+1	CDKN1B,CCND1,CDKN1A
REAC:R-HSA-6802952	Signaling by BRAF and RAF fusions	0.047603942865555714	0.047603942865555714	+1	KRAS,NRAS,BRAF