Higher order grouping of Pfam families CC0-1.0 Pfam protein clan PyOBO v0.12.13-dev-207b46e9 on 2025-10-30T21:36:52.088605 by https://github.com/biopragmatics/pyobo/blob/main/src/pyobo/sources/pfam/pfam_clan.py 38.0 https://pfam.xfam.org https://upload.wikimedia.org/wikipedia/commons/0/03/Pfam_logo.gif EGF SAM Concanavalin Kazal KH SH3 Histone Beta-lactamase Glutaminase_I MFS PKinase bZIP TPR OB LRR P-loop_NTPase His_Kinase_A CU_oxidase RdRP AB_hydrolase Cupin Ion_channel Phosphatase Dim_A_B_barrel POZ TIM_barrel Lysozyme HUP tRNA_synt_II Death Flavoprotein Chelatase Ferritin Thiolase CuAO_N2_N3 LolA_LolB HotDog NTF2 NTN 4H_Cytokine Knottin_1 Nucleoplasmin C_Lectin Met_repress 6_Hairpin DNA_clamp PLP_aminotran APC NADP_Rossmann CPA_AT Cyclin Trefoil SIS RIIa GFP ACT His_phosphatase Ubiquitin P53-like Matrix Defensin FAD_PCMH Cystine-knot Beta-tent MBD-like MIF Omega_toxin ADP-ribosyl Acyl-CoA_dh Alk_phosphatase GlnB-like Globin NAD_Ferredoxin ADF Peptidase_CD Peptidase_ME Peptidase_ML Pept_Inhib_IE TypeIII_Chap SPOUT ALDH-like C1q_TNF PELOTA Gal_mutarotase Glyoxalase Hybrid 6PGD_C Actin_ATPase CDA GT-A GT-C Yip1 GT-B HMG-box Steroid_dh Calycin uPAR_Ly6_toxin Ribokinase UTRA HTH Peptidase_PA Peptidase_CA Peptidase_MA ClpP_crotonase vWA-like Peptidase_AA Peptidase_AD DoxD-like AbrB AT14A-like Arrestin_N-like Plasmid_toxin HAD GADPH_aa-bio_dh Viral_NABP MtN3-like Membrane_trans B_Fructosidase Periplas_BP Golgi-transport Herpes_glyco Viral_Gag CoA-acyltrans dUTPase C2 CBM_14_19 Nucleocapsid Kleisin GH_CE E-set GAF Calcineurin CUB Cache PRD Zn_Beta_Ribbon PAN Rep Peptidase_MD Phospoesterase Thioredoxin STIR TetR_C TRASH Chemosens_recp PBP PUA ATP-grasp ABC-2 IT PAS_Fold DMT Beta_propeller LysM CH HSP20 POTRA GPCR_A MBB DNA_pol_B-like DBL DSRM GME HHH DPBB Prefoldin Peptidase_SH GBD CBD Adhesin Di-copper Rhomboid-like UBC Bet_v_1_like HNOX-like SNARE ShK-like UBA Rotavirus_VP7 RNase_H EF_hand RRM MviN_MATE MACRO DHQS FtsL M6PR Enolase_N Acyltransferase RING HO MazG NifU SufE_NifU CTPT PspA PDDEXK HD_PDEase PP2C Insulin PFK ABC_membrane DNA_primase_lrg AEP PGBD EDD 2H ParB_Srx Phage_tail_L GAD MORN THDP-binding ATP_synthase Acetyltrans DALR OstA NTP_transf NUDIX Trigger_C His-Me_finger SGNH_hydrolase HIT PH S11_L18p Pec_lyase-like Maf Iso_DH F-box RGS CYTH WRKY-GCM1 Nucleot_cyclase FAD-oxidase_C AIG2 GatB_YqeY PIN CCT Serum_albumin LigB Allatostatin YycI_YycH GCS Transthyretin DAP_epimerase FBD EPT_RTPC KNTase_C LysE CDC GroES PhoU tRNA_bind_arm Peptidase_SF TAT PA14 Arginase H2TH CheY PTH2 HeH FUSC DMSO_reductase DinB SCP2 HemS_ChuX PP-binding Gx_transp Acyl_transf_3 Multiheme_cytos Cytochrome-c SHS2 PepSY PLAT RND_permease Patatin Homing_endonuc Reo_sigma Pilus 2heme_cytochrom S5 AVL9 EpsM gCrystallin THBO-biosyn FumRed-TM FMN-binding RF PFL-like PTase-anion_tr LDH_C TolB_N MHC 4Fe-4S Aerolisin_ETX Ribo_L29 TSPAN_4TM-like Phage_tail SLOG PRC-barrel CHCH EsxAB TIMP-like bBprotInhib CheC-like AMP_N-like SMAD-FHA Intron-mat_II MTH1187-YkoF C2H2-zf RAMPS-Cas5-like H-int Leu-IlvD JAB CI-2 PhosC-NucP1 GHD Uteroglobin Inovirus-Coat Phage-coat PEP-carboxyk Transporter Oxa1 FAH ANL PgaPase IDO-like Metallo-HOrase DNA-mend PheT-TilS Hydrophilin DHFred FadR-C TRAF CAP_C-like Chaperone-J DsrEFH-like Tubby_C Marvel-like TusA-like RMMBL_DRMBL Asp-glut_race GG-leader Cdc48_2-like ADC-like BPD_transp_1 DNA_b-psBarrel YjbJ-CsbD-like TBP-like PUP GAP LEF-8-like Vir Frag1-like Toprim-like TerB Anoctamin-like BIR-like GIY-YIG T3SS-Chaperone GlpM-like LppaM Fibrinogen_C AhpD-like T3SS-hook ComplexI-N HRDC-like TolA-TonB-Cterm UcrQ-like CopD_like PF SPFH NPR FliG EF-G_C NusG-like AlbA Tubulin_C SNARE-fusion Bacteriocin_TLN Hypoth_1 Cargo_bd_muHD G-PATCH FnI-like Tropomyosin-lke Apoptosis-Inhib Golgi_traff 4HB_MCP IIaaRS-ABD BRCT-like Metallothionein TPA-repeat 5_3_exonuc_C Ank PDZ-like l-integrase_N ThrE DUF362 Peptidase_U SICA_like Cyclophil-like tRNA-IECD_N TRD ATPase_I_AtpR PLD HUH Prolamin Peroxisome Fer2 FKBP FixH-like SAF PepSY_TM-like LYR-like S4 PTS_EIIC DnaA_N Tad-like GST_C Nribosyltransf O-anti_assembly Glycine-zipper STAS Phage_barrel Pentapeptide Succ_CoA_synth Fungal_trans YkuD RBP11-like Retroviral_zf CRAL_TRIO LCCL-domain LTXXQ-like ISP-domain MBOAT-like Keratin_assoc GOLD-like YbjQ-like GAG-polyprotein MPT63-MPB63 pap2 SUKH DUF1214 FMN-dep-NRtase DNase_I-like AMP-binding_C LIG PRTase-like YjgF-like CBM HEXAPEP CCCH_zf RNase_III GCP SH2-like RAS_GEF_N Viral_gly_cn_dm AcylCoA_ox_dh_N APCOP-app_sub Hexosaminidase GF_recep_C-rich IHF-likeDNA-bdg SRCR BCLiA Hect CBD9-like Chalcone-like LisH Holin-V Holin-II Holin-III Phage_TACs Man_lectin PPP-I 30K_movement TIKI KA1-like STARBD Paramyxovirin_C AbiEI YqgF TrkA_C FF CTC1 STAND_N Ribos_L15p_L18e KIX_like OML_zippers TKC_like beta_Roll G5 Fusion_gly VPS23_C Post-HMGL B_GA GH57_38_middle S15_NS1 Cob_adeno_trans Kringle AA_dh_N post-AAA ssDNA_NP_VP Phage_fibre TNF_receptor Reductase_C sPC4_like Hexon PHM_PNGase_F Terp_synthase L27 ALDC SPOC Peroxidase MCR Mog1p_PsbP Antihemostatic Colipase Acylphosphatase SRP9_14 eIF4e Levi_coat Antibiotic_NAT EspA_CesA PLA2 PSI YgaC_TfoX-N FERM_M NusB CheY-binding DmpA_ArgJ Leukocidin KaiA_RbsU Rof Colicin_D_E5 SOCS_box YqbG Fz Anti-sigma_N T3SS FG_rpt Aha1_BPI PseudoU_synth AOC_barrel Mad2 S24e_L23_L15e VCCI WYL PilP VSA OB_enterotoxin CAP SHOCT Gain Triple_barrel CNF1_YfiH UB2H BET Vault Fer2_BFD Pre-PUA NOG1_N 4PPT AAA_lid p35 GYF Triple_B_spiral SLATT GHMP_C CLIP TACC WW HAMP MBG MICOS NFACT_RNA-bind AmpE_CobD-like aG_PT Zn_chelatase BECR TSP3 TrbC_VirB2 Tail_Terminator TSP1 Cas9_lobe Choline_binding EndoU Vmethyltransf SDH_beta TrbL ArdcN NAD_kinase_C UIM YtcA HMA VBS-like EMC6 Saposin_like Polo-box STING YeeE Acyl-CoA_desat COX1-like Nckap1_CYFIP1-2 Aquaporin-like YbaB Perilipin_sf Moesin_tail Lag3_N LAMP SDH_alpha TRADD-N Kinetochore Apolipoprotein Resistin Nucleosidase Cas2 Kre28-like_sf IL8 SPOCS RMP1-like Ribosomal_L25 Rpp14-Pop5-like GatC-like Get5_C_sf Mtd Arg_repressor_C GCV_T_C RGM PTS_IIA-like Spectrin MIT AFF4_CHD THUMP DNA_prim_N GH127_M ADAM_CR_sf Secretin_N0 PsbQ-like ATPD-E_C PGM_I-III SASP GMC TRAP L31 Nop_N_sf RBG ABC_sf GlyR GpW_gp25-like PHP14-like PAC NCPF MXAN_049 DUF960 SsdA_imm GH84_C UDG-like YqiB STD MTHFR_C-like MlaD-like PBP_NTD XRCC4_N BON Head_shaft LppM-like NadN_C BBOX WWE VPS9 H-NS_histone_C NADAR-like CorA-like SUD_C-like Cas9_WED-like Ago_N MLKL_N-like GspE_N-like Mur_ligase_C_sf NSUN_ferredox Mu-transpos_C RXXXE-like INSIG-like PRMT_C LiaI-LiaF-TM OST_core MinC_N PBP_GOBP PurM_N-like PWI-like SNaCT WY-like Sufu_N CXC GRIP-like YKT-like_S COMMD_HN Brichos_S BACOVA_03322_C TBC-like SPMIP5_TBD GT-D-like TIL RBAF-like C4-like WIV XPD_ARCH HHD CTLH NuiA-like bHLH PABC-like PAH SAND CobW_C Nup120_hel_sf BAAB_hairpin MYCPN_LP TMEM126 Phage_portal Tbcl_zf H_lectin Wzc_PBSD UPA-like MFPT-like Matrix_Mononaga Beta_tulip HVO_1158-like Ice_binding YphA 3b-a_propeller INO80_complex YhhM-like DH-like TMD0-like DGR_Avd-like TMMD-like Imm33 APA-like ColE3imm-like DMP12-like LMG18311-like MavL-like_sf LTE-like NACHT_N ZnExoPePases ALR_C-like NqrA_FMN-like p22phox-like AraA_N-like EXR-like YefM-like PfC-like RBM_T3SS-Flag PMD-like MscS_C_sf SLD5_C-like RHS_sf CamS-like R3H-like SLC44-like SUEL-RBL_sf Agd3_CE_sf CBM87 MmeI_HD-like L9_N_sp ADH_DHQS_C-like MliC_ACP-like CoiA_N-like DmsR_N-like Haemocyanin_C Cry1_MapZ SNYG AD BPTI DnaJ_CRD Pseudo_EF-hand Bestrophin AraD-like HR1 RND_hairpin MFP_C Tic20_MamF_MmsF MCM_N CBM_starch M29-like SWIB FliM_C FlgN_FLiT ATG7_N TraC CHCC_shd CcmS-like PA3496-like Zn2_Cys6 HET_barrel SRI