The Pathway Interaction Database is a highly-structured, curated collection of information about known human biomolecular interactions and key cellular processes assembled into signaling pathways. This datatype provides access to pathway information. NCI Pathway Interaction Database: Pathway PyOBO v0.12.13-dev-207b46e9 on 2025-10-30T20:26:11.622146 by https://github.com/biopragmatics/pyobo/blob/main/src/pyobo/sources/pid.py 1.0.0 https://www.ndexbio.org/index.html#/networkset/8a2d7ee9-1513-11e9-bb6a-0ac135e8bacf https://home.ndexbio.org/img/pid-logo-ndex.jpg Inverse of has participant has participant p53 pathway Signaling events mediated by HDAC Class II IL2-mediated signaling events E-cadherin signaling in keratinocytes Signaling events mediated by HDAC Class III p73 transcription factor network FOXA1 transcription factor network Signaling events mediated by Hepatocyte Growth Factor Receptor (c-Met) E-cadherin signaling in the nascent adherens junction p75(NTR)-mediated signaling FOXA2 and FOXA3 transcription factor networks CXCR3-mediated signaling events Coregulation of Androgen receptor activity IL23-mediated signaling events Class IB PI3K non-lipid kinase events Class I PI3K signaling events Class I PI3K signaling events mediated by Akt Circadian rhythm pathway Ceramide signaling pathway Cellular roles of Anthrax toxin CDC42 signaling events CD40CD40L signaling Caspase Cascade in Apoptosis Canonical Wnt signaling pathway Canonical NF-kappaB pathway Calcium signaling in the CD4 TCR pathway Calcineurin-regulated NFAT-dependent transcription in lymphocytes C-MYC pathway C-MYB transcription factor network E2F transcription factor network Signaling events mediated by PRL Signaling events mediated by PTP1B PAR1-mediated thrombin signaling events IL27-mediated signaling events PAR4-mediated thrombin signaling events FOXM1 transcription factor network PDGF receptor signaling network PDGFR-alpha signaling pathway Signaling events mediated by Stem cell factor receptor (c-Kit) IL3-mediated signaling events PDGFR-beta signaling pathway Signaling events mediated by TCPTP IL4-mediated signaling events FoxO family signaling Effects of Botulinum toxin Signaling events mediated by the Hedgehog family EGFR-dependent Endothelin signaling events Signaling events mediated by VEGFR1 and VEGFR2 Endogenous TLR signaling Plasma membrane estrogen receptor signaling Endothelins Glucocorticoid receptor regulatory network IL5-mediated signaling events Plexin-D1 Signaling Signaling events regulated by Ret tyrosine kinase PLK1 signaling events IL6-mediated signaling events Signaling mediated by p38-alpha and p38-beta PLK3 signaling events Posttranslational regulation of adherens junction stability and dissassembly Signaling mediated by p38-gamma and p38-delta Sphingosine 1-phosphate (S1P) pathway Stabilization and expansion of the E-cadherin adherens junction EPHA forward signaling Presenilin action in Notch and Wnt signaling IL8- and CXCR1-mediated signaling events Sumoylation by RanBP2 regulates transcriptional repression Syndecan-1-mediated signaling events RAC1 signaling pathway EGF_receptor_(ErbB1)_signaling_pathway EPHA2 forward signaling Glypican 1 network Downstream signaling in nave CD8 T cells Syndecan-2-mediated signaling events IL8- and CXCR2-mediated signaling events TCR signaling in nave CD4 T cells Regulation of CDC42 activity EPHB forward signaling Rapid glucocorticoid signaling Ras signaling in the CD4 TCR pathway Syndecan-3-mediated signaling events Reelin signaling pathway Glypican 2 network Insulin Pathway Syndecan-4-mediated signaling events Glypican 3 network Regulation of Androgen receptor activity GMCSF-mediated signaling events Integrin family cell surface interactions TGF-beta receptor signaling Regulation of cytoplasmic and nuclear SMAD23 signaling Ephrin A reverse signaling Insulin-mediated glucose transport Ephrin B reverse signaling TCR signaling in nave CD8 T cells Hedgehog signaling events mediated by Gli proteins Regulation of nuclear beta catenin signaling and target gene transcription ErbB receptor signaling network Integrins in angiogenesis HIF-1-alpha transcription factor network EPO signaling pathway Integrin-linked kinase signaling Regulation of nuclear SMAD23 signaling Thromboxane A2 receptor signaling TRAIL signaling pathway Internalization of ErbB1 Alpha-synuclein signaling Alpha4 beta1 integrin signaling events Alpha6 beta4 integrin-ligand interactions ErbB1 downstream signaling Regulation of p38-alpha and p38-beta TNF receptor signaling pathway a4b7 Integrin signaling Regulation of RAC1 activity a6b1 and a6b4 Integrin signaling HIF-2-alpha transcription factor network ALK1 signaling events ALK2 signaling events Regulation of Ras family activation Arf6 downstream pathway LPA receptor mediated events Arf6 signaling events Hypoxic and oxygen homeostasis regulation of HIF-1-alpha Arf6 trafficking events Regulation of Telomerase ATF-2 transcription factor network JNK signaling in the CD4 TCR pathway Alpha9 beta1 integrin signaling events Trk receptor signaling mediated by PI3K and PLC-gamma Regulation of retinoblastoma protein HIV-1 Nef Negative effector of Fas and TNF-alpha Lissencephaly gene (LIS1) in neuronal migration and development Alternative NF-kappaB pathway amb2 Integrin signaling Angiopoietin receptor Tie2-mediated signaling CXCR4-mediated signaling events LKB1 signaling events AP-1 transcription factor network Arf1 pathway Regulation of RhoA activity Trk receptor signaling mediated by the MAPK pathway BARD1 signaling events BCR signaling pathway RhoA signaling pathway Beta1 integrin cell surface interactions IGF1 pathway Beta2 integrin cell surface interactions Validated nuclear estrogen receptor beta network N-cadherin signaling events Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling IFN-gamma pathway ErbB2ErbB3 signaling events ATM pathway ATR signaling pathway LPA4-mediated signaling events Atypical NF-kappaB pathway Aurora A signaling mTOR signaling pathway Aurora B signaling Retinoic acid receptors-mediated signaling Validated nuclear estrogen receptor alpha network Aurora C signaling Validated targets of C-MYC transcriptional repression Fanconi anemia pathway RXR and RAR heterodimerization with other nuclear receptor NephrinNeph1 signaling in the kidney podocyte Beta3 integrin cell surface interactions Degradation of beta catenin Role of Calcineurin-dependent NFAT signaling in lymphocytes Validated targets of C-MYC transcriptional activation Beta5 beta6 beta7 and beta8 integrin cell surface interactions ErbB4 signaling events BMP receptor signaling Direct p53 effectors IL1-mediated signaling events Nectin adhesion pathway IL12-mediated signaling events S1P3 pathway Validated transcriptional targets of deltaNp63 isoforms Noncanonical Wnt signaling pathway Netrin-mediated signaling events IL12 signaling mediated by STAT4 S1P1 pathway Validated transcriptional targets of AP1 family members Fra1 and Fra2 Neurotrophic factor-mediated Trk receptor signaling S1P2 pathway FAS (CD95) signaling pathway VEGFR1 specific signals IL2 signaling events mediated by PI3K DNA-PK pathway in nonhomologous end joining Notch-mediated HESHEY network Signaling events mediated by focal adhesion kinase Validated transcriptional targets of TAp63 isoforms S1P4 pathway Nongenotropic Androgen signaling S1P5 pathway SHP2 signaling Fc-epsilon receptor I signaling in mast cells Notch signaling pathway VEGF and VEGFR signaling network p38 signaling mediated by MAPKAP kinases VEGFR3 signaling in lymphatic endothelium Osteopontin-mediated events Visual signal transduction Cones Visual signal transduction Rods Signaling events mediated by HDAC Class I FGF signaling pathway Wnt signaling network p38 MAPK signaling pathway IL2 signaling events mediated by STAT5