### Output files #### Mode `cis_nominal` Column | Description --- | --- `phenotype_id` | Phenotype ID `variant_id` | Variant ID `start_distance` | Distance between the variant and phenotype start position (e.g., TSS) `end_distance` | Distance between the variant and phenotype end position (only present if different from start position) `af` | In-sample ALT allele frequency of the variant `ma_samples` | Number of samples carrying at least on minor allele `ma_count` | Number of minor alleles `pval_nominal` | Nominal p-value of the association between the phenotype and variant `slope` | Regression slope `slope_se` | Standard error of the regression slope #### Mode `cis_nominal`, with interaction term When an interaction term is included, the output additionally contains the following columns instead of `pval_nominal`, `slope`, `slope_se`: Column | Description --- | --- `pval_g` | Nominal p-value of the genotype term `b_g` | Slope of the genotype term `b_g_se` | Standard error of `b_g` `pval_i` | Nominal p-value of the interaction variable `b_i` | Slope of the interaction variable `b_i_se` | Standard error of `b_i` `pval_gi` | Nominal p-value of the interaction term `b_gi` | Slope of the interaction term `b_gi_se` | Standard error of `b_gi` `tests_emt` | Effective number of independent variants (Meff) estimated by eigenMT `pval_emt` | Bonferroni-adjusted `pval_gi` (i.e., multiplied by Meff) `pval_adj_bh` | Benjamini-Hochberg adjusted `pval_emt` #### Mode `cis` Column | Description --- | --- `phenotype_id` | Phenotype ID `num_var` | Number of variants in *cis*-window `beta_shape1` | Parameter of the fitted Beta distribution `beta_shape2` | Parameter of the fitted Beta distribution `true_df` | Degrees of freedom used to compute p-values `pval_true_df` | Nominal p-value based on `true_df` `variant_id` | Variant ID `start_distance` | Distance between the variant and phenotype start position (e.g., TSS) `end_distance` | Distance between the variant and phenotype end position (only present if different from start position) `ma_samples` | Number of samples carrying at least on minor allele `ma_count` | Number of minor alleles `af` | In-sample ALT allele frequency of the variant `pval_nominal` | Nominal p-value of the association between the phenotype and variant `slope` | Regression slope `slope_se` | Standard error of the regression slope `pval_perm` | Empirical p-value from permutations `pval_beta` | Beta-approximated empirical p-value `qval` | Storey q-value corresponding to `pval_beta` `pval_nominal_threshold` | Nominal p-value threshold for significant associations with the phenotype #### Mode `cis_independent` The columns are the same as for `cis`, excluding `qval` and `pval_nominal_threshold`, and adding: Column | Description --- | --- `rank` | Rank of the variant for the phenotype #### Mode `trans` Column | Description --- | --- `variant_id` | Variant ID `phenotype_id` | Phenotype ID `pval` | Nominal p-value of the association between the phenotype and variant `b` | Regression slope `b_se` | Standard error of the regression slope `r2` | Squared residual genotype-phenotype correlation (only generated if `map_trans(..., return_r2=True)`) `af` | In-sample ALT allele frequency of the variant