Are the anti inflammatory effects of ES-62 in vivo mediated at the level of dendritic cell-T cell priming.
The family Bunyaviridae is one of the largest taxonomic groupings of RNA viruses, containing well over 300 named isolates. Among the unifying characteristics of these viruses is possession of a tri-segmented single- stranded RNA genome of negative- or ambi-sense polarity that encodes four structural proteins. The three genome segments (called L [large], M [medium] and S [small]) are encapsidated by the nucleocapsid (N) protein and are associated with the viral RNA-dependent RNA polymerase, the L protein, to form ribonucleoprotein complexes (RNP) termed nucleocapsids. The three RNPs are contain