@prefix owl: <http://www.w3.org/2002/07/owl#> .
@prefix dc: <http://purl.org/dc/terms/> .
@prefix rdfs: <http://www.w3.org/2000/01/rdf-schema#> .
@prefix seer-kb: <http://idea.tw.rpi.edu/projects/heals/kb/seer#> .
@prefix ncit: <http://purl.obolibrary.org/obo/NCIT_> .
@prefix sio: <http://semanticscience.org/resource/> .
@prefix cst: <http://idea.tw.rpi.edu/projects/heals/ontologies/cancer_staging_terms.owl#> .
@prefix xsd: <http://www.w3.org/2001/XMLSchema#> .
@prefix : <http://idea.tw.rpi.edu/projects/heals/ontologies/cancer_staging_terms.owl#> .

<http://idea.tw.rpi.edu/projects/heals/ontologies/cancer_staging_terms.owl>
  a owl:Ontology ;
  dc:license <http://www.apache.org/licenses/LICENSE-2.0> .

:R7_Stage a owl:Class ;
	rdfs:comment "Breast Cancer Stage pertaining to AJCC 7th Edition Guidelines"^^xsd:string ;
	rdfs:label "AJCC 7th Edition Stage"^^xsd:string.

:R7_Stage_0 a owl:Class ;
	rdfs:comment "A non-invasive cancer where abnormal cells have been found in the lining of the breast milk duct where the atypical cells have not spread outside of the ducts or lobules into the surrounding breast tissue"^^xsd:string ;
	rdfs:label "Stage 0 (AJCC 7th Edition)"^^xsd:string ;
    rdfs:subClassOf :R7_Stage .

:R7_Stage_I a owl:Class ;
	rdfs:comment "Cancer is evident, but it is contained to only the area where the first abnormal cells began to develop. The breast cancer has been detected in the early stages and can be very effectively treated."^^xsd:string ;
	rdfs:label "Stage I"^^xsd:string ;
    rdfs:subClassOf :R7_Stage .

:R7_Stage_IA a owl:Class ;
	rdfs:comment "The tumor is smaller is 20mm or smaller and has not spread to the lymph nodes."^^xsd:string ;
	rdfs:label "Stage IA (AJCC 7th Edition)"^^xsd:string ;
    rdfs:subClassOf :R7_Stage_I .

:R7_Stage_IB a owl:Class ;
	rdfs:comment "Lymph nodes have cancer evidence with small clusters of cells between the approximate size of 0.2mm to 2.0 mm."^^xsd:string ;
	rdfs:label "Stage IB (AJCC 7th Edition)"^^xsd:string ;
    rdfs:subClassOf :R7_Stage_I .

:R7_Stage_II a owl:Class ;
	rdfs:comment "The breast cancer is growing, but it is still contained in the breast or growth has only extended to the nearby lymph nodes."^^xsd:string ;
	rdfs:label "Stage II"^^xsd:string ;
    rdfs:subClassOf :R7_Stage .

:R7_Stage_IIA a owl:Class ;
	rdfs:comment "No actual tumor is associated with the cancerous cells and less than four auxillary lymph nodes have cancer cells present. The tumor is less than 2 centimeters and less than four auxillary lymph nodes have cancer cells present"^^xsd:string ;
	rdfs:label "Stage IIA (AJCC 7th Edition)"^^xsd:string ;
    rdfs:subClassOf :R7_Stage_II .

:R7_Stage_IIB a owl:Class ;
	rdfs:comment "The tumor is between the 2 and 5 centimeters and has spread to less than four axillary lymph nodes. The tumor is larger than five centimeters, but has not spread to any axillary lymph nodes"^^xsd:string ;
	rdfs:label "Stage IIB (AJCC 7th Edition)"^^xsd:string ;
    rdfs:subClassOf :R7_Stage_II .

:R7_Stage_III a owl:Class ;
	rdfs:comment "Cancer has extended to beyond the immediate region of the tumor and may have invaded nearby lymph nodes and muscles, but has not spread to distant organs"^^xsd:string ;
	rdfs:label "Stage III"^^xsd:string ;
    rdfs:subClassOf :R7_Stage .

:R7_Stage_IIIA a owl:Class ;
	rdfs:comment "The tumor is larger than the 50mm, and small clusters of breast cancer cells are found in the lymph nodes between the size of 0.2 mm - 2.0 mm"^^xsd:string ;
	rdfs:label "Stage IIIA (AJCC 7th Edition)"^^xsd:string ;
    rdfs:subClassOf :R7_Stage_III .

:R7_Stage_IIIB a owl:Class ;
	rdfs:comment "The tumor may be of any size, and cancer has invaded the chest wall or breast skin with evidence of swelling, inflammation, or ulcers (such as with cases like inflammatory breast cancer). The cancer may also have invaded up to 9 nearby lymph nodes"^^xsd:string ;
	rdfs:label "Stage IIIB (AJCC 7th Edition)"^^xsd:string ;
    rdfs:subClassOf :R7_Stage_III .

:R7_Stage_IIIC a owl:Class ;
	rdfs:comment "No actual tumor is found in the breast (such as with cases like inflammatory breast cancer) or the tumor may be of any size. Cancer may have invaded the chest wall or breast skin with evidence of swelling, inflammation, or ulcers and cancer has also invaded 10 or more lymph nodes under the arm"^^xsd:string ;
	rdfs:label "Stage IIIC (AJCC 7th Edition)"^^xsd:string ;
    rdfs:subClassOf :R7_Stage_III .

:R7_Stage_IV a owl:Class ;
	rdfs:comment "Cancer has spread beyond the breast and nearby lymph nodes to other organs of the body, such as the lungs, distant lymph nodes, skin, bones, liver, or brain"^^xsd:string ;
	rdfs:label "Stage IV (AJCC 7th Edition)"^^xsd:string ;
    rdfs:subClassOf :R7_Stage  .

:R8_Stage a owl:Class ;
	rdfs:comment "Breast Cancer Stage pertaining to AJCC 8th Edition Guidelines"^^xsd:string ;
	rdfs:label "AJCC 8th Edition Stage".

:R8_Stage_0 a owl:Class ;
	rdfs:comment "A non-invasive cancer where abnormal cells have been found in the lining of the breast milk duct where the atypical cells have not spread outside of the ducts or lobules into the surrounding breast tissue"^^xsd:string ;
	rdfs:label ""^^xsd:string ;
	rdfs:label "Stage 0"^^xsd:string ;
    rdfs:subClassOf :R8_Stage .

:R8_Stage_I a owl:Class ;
	rdfs:comment "Cancer is evident, but it is contained to only the area where the first abnormal cells began to develop. The breast cancer has been detected in the early stages and can be very effectively treated."^^xsd:string ;
	rdfs:label "Stage I"^^xsd:string ;
    rdfs:subClassOf :R8_Stage ;
    cst:hasRecommendedTest "Mammogram"^^xsd:string ,
                            "Lymph Node Biopsy"^^xsd:string ,
                            "Receptor Tests"^^xsd:string ;
    cst:hasTreatmentOption "Radiation Therapy"^^xsd:string ,
                            "Endocrine Therapy"^^xsd:string,
                            "Surgery"^^xsd:string .

:R8_Stage_IA a owl:Class ;
	rdfs:comment "The tumor is smaller is 20mm or smaller and has not spread to the lymph nodes."^^xsd:string ;
	rdfs:label "Stage IA"^^xsd:string ;
    rdfs:subClassOf :R8_Stage_I .

:R8_Stage_IB a owl:Class ;
	rdfs:comment "Lymph nodes have cancer evidence with small clusters of cells between the approximate size of 0.2mm to 2.0 mm."^^xsd:string ;
	rdfs:label "Stage IB"^^xsd:string ;
    rdfs:subClassOf :R8_Stage_I .

:R8_Stage_II a owl:Class ;
	rdfs:comment "The breast cancer is growing, but it is still contained in the breast or growth has only extended to the nearby lymph nodes."^^xsd:string ;
	rdfs:label "Stage II"^^xsd:string ;
    rdfs:subClassOf :R8_Stage ;
    cst:hasRecommendedTest "Mammogram"^^xsd:string ,
                            "Lymph Node Biopsy"^^xsd:string ,
                            "Receptor Tests"^^xsd:string ;
    cst:hasTreatmentOption "Radiation Therapy"^^xsd:string ,
                            "Endocrine Therapy"^^xsd:string,
                            "Surgery"^^xsd:string .

:R8_Stage_IIA a owl:Class ;
	rdfs:comment "No actual tumor is associated with the cancerous cells and less than four auxillary lymph nodes have cancer cells present. The tumor is less than 2 centimeters and less than four auxillary lymph nodes have cancer cells present."^^xsd:string ;
	rdfs:label "Stage IIA"^^xsd:string ;
    rdfs:subClassOf :R8_Stage_II .

:R8_Stage_IIB a owl:Class ;
	rdfs:comment "The tumor is between the 2 and 5 centimeters and has spread to less than four axillary lymph nodes. The tumor is larger than five centimeters, but has not spread to any axillary lymph nodes."^^xsd:string ;
	rdfs:label "Stage IIB"^^xsd:string ;
    rdfs:subClassOf :R8_Stage_II .

:R8_Stage_III a owl:Class ;
	rdfs:comment "Cancer has extended to beyond the immediate region of the tumor and may have invaded nearby lymph nodes and muscles, but has not spread to distant organs"^^xsd:string ;
	rdfs:label "Stage III"^^xsd:string ;
    rdfs:subClassOf :R8_Stage ;
    cst:hasRecommendedTest "Breast Biopsy"^^xsd:string ,
                            "Bone Scan"^^xsd:string ,
                            "HER2 Test"^^xsd:string ,
                            "Histologic Typing"^^xsd:string ;
    cst:hasTreatmentOption "Chemotherapy"^^xsd:string ,
                            "Mastectomy"^^xsd:string ,
                            "Lumpectomy"^^xsd:string .

:R8_Stage_IIIA a owl:Class ;
	rdfs:comment "The tumor is larger than the 50mm, and small clusters of breast cancer cells are found in the lymph nodes between the size of 0.2 mm - 2.0 mm"^^xsd:string ;
	rdfs:label "Stage IIIA"^^xsd:string ;
    rdfs:subClassOf :R8_Stage_III .

:R8_Stage_IIIB a owl:Class ;
	rdfs:comment "The tumor may be of any size, and cancer has invaded the chest wall or breast skin with evidence of swelling, inflammation, or ulcers (such as with cases like inflammatory breast cancer). The cancer may also have invaded up to 9 nearby lymph nodes"^^xsd:string ;
	rdfs:label "Stage IIIB"^^xsd:string ;
    rdfs:subClassOf :R8_Stage_III .

:R8_Stage_IIIC a owl:Class ;
	rdfs:comment "No actual tumor is found in the breast (such as with cases like inflammatory breast cancer) or the tumor may be of any size. Cancer may have invaded the chest wall or breast skin with evidence of swelling, inflammation, or ulcers and cancer has also invaded 10 or more lymph nodes under the arm"^^xsd:string ;
	rdfs:label ""^^xsd:string ;
	rdfs:label "Stage IIIC"^^xsd:string ;
    rdfs:subClassOf :R8_Stage_III .

:R8_Stage_IV a owl:Class ;
	rdfs:comment "Cancer has spread beyond the breast and nearby lymph nodes to other organs of the body, such as the lungs, distant lymph nodes, skin, bones, liver, or brain"^^xsd:string ;
	rdfs:label "Stage IV"^^xsd:string ;
    rdfs:subClassOf :R8_Stage ;
    cst:hasRecommendedTest "Pathology Report"^^xsd:string ,
                            "Receptor Testing"^^xsd:string ,
                            "Hormone Receptor Test"^^xsd:string ,
                            "HER2 Test"^^xsd:string ,
                            "Histologic Typing"^^xsd:string ;
    cst:hasTreatmentOption "Chemotherapy"^^xsd:string ,
                            "Targeted Therapy"^^xsd:string ,
                            "Whole Body Treatment"^^xsd:string .

:T a owl:Class ;
	rdfs:comment "Tumor Size Stage Finding"^^xsd:string ;
    rdfs:label "Generic T Stage Finding"^^xsd:string ;
	owl:equivalentClass ncit:C48885 .

:T0 a owl:Class ;
    rdfs:label "T0 Stage Finding"^^xsd:string ;
    rdfs:comment "Primary tumor cannot be found (no evidence of tumor)"^^xsd:string ;
	owl:equivalentClass ncit:C48719 ;
    rdfs:subClassOf :T .

:Tis a owl:Class ;
	rdfs:label "Tis Stage Finding"^^xsd:string ;
	rdfs:comment "Carcinoma In Situ"^^xsd:string ;
	owl:equivalentClass ncit:C48738 ;
    rdfs:subClassOf :T .

:T1 a owl:Class ;
	rdfs:comment "Tumor 20 mm or less in greatest dimension"^^xsd:string ;
	rdfs:label "T1 Stage Finding"^^xsd:string ;
	owl:equivalentClass ncit:C48720 ;
    rdfs:subClassOf :T .

:T1a a owl:Class ;
	rdfs:label "T1a Stage Finding"^^xsd:string ;
	rdfs:comment "Tumor greater than 1 mm, less than or equal to 5 mm in greatest dimension"^^xsd:string ;
    	rdfs:subClassOf :T1 ;
	owl:equivalentClass ncit:C48721 .

:T1a_m  a owl:Class ;
	rdfs:comment ""^^xsd:string ;
	rdfs:label "T1a(m) Stage Finding"^^xsd:string ;
	rdfs:subClassOf :T1a .

:T1a_s  a owl:Class ;
	rdfs:comment ""^^xsd:string ;
	rdfs:label "T1a(s) Stage Finding"^^xsd:string ;
	rdfs:subClassOf :T1a .

:T1a1  a owl:Class ;
	rdfs:comment ""^^xsd:string ;
	rdfs:label "T1a1 Stage Finding"^^xsd:string ;
	rdfs:subClassOf :T1a .

:T1a2  a owl:Class ;
	rdfs:comment ""^^xsd:string ;
	rdfs:label "T1a2 Stage Finding"^^xsd:string ;
	rdfs:subClassOf :T1a .

:T1b a owl:Class ;
	rdfs:comment "Tumor greater than 5 mm, less than or equal to 10 mm in greatest dimension"  ;
    rdfs:subClassOf :T1 ;
	owl:equivalentClass ncit:C48722 .

:T1b1  a owl:Class ;
	rdfs:comment ""^^xsd:string ;
	rdfs:label "T1b1 Stage Finding"^^xsd:string ;
	rdfs:subClassOf :T1b .

:T1b2  a owl:Class ;
	rdfs:comment ""^^xsd:string ;
	rdfs:label "T1b2 Stage Finding"^^xsd:string ;
	rdfs:subClassOf :T1b .

:T1b_m  a owl:Class ;
	rdfs:comment ""^^xsd:string ;
	rdfs:label "T1b(m) Stage Finding"^^xsd:string ;
	rdfs:subClassOf :T1b .

:T1b_s  a owl:Class ;
	rdfs:comment ""^^xsd:string ;
	rdfs:label "T1b(s) Stage Finding"^^xsd:string ;
	rdfs:subClassOf :T1b .

:T1c a owl:Class ;
	rdfs:label "T1c Stage Finding"^^xsd:string ;
	rdfs:comment "Tumor greater than 10 mm, less than or equal to 20 mm in greatest dimension"  ;
    	rdfs:subClassOf :T1 ;
	owl:equivalentClass ncit:C48723 .

:T1d  a owl:Class ;
	rdfs:comment ""^^xsd:string ;
	rdfs:label "T1d Stage Finding"^^xsd:string ;
	rdfs:subClassOf :T1 .

:T1mic a owl:Class ;
	rdfs:label "T1mic Stage Finding"^^xsd:string ;
	rdfs:comment "Microinvasion of 0.1 cm or less in its largest dimension"^^xsd:string ;
    	rdfs:subClassOf :T1 ;
	owl:equivalentClass ncit:C95805 .

:T1NOS a owl:Class ;
	rdfs:comment ""^^xsd:string ;
	rdfs:label "T1NOS Stage Finding"^^xsd:string ;
	rdfs:subClassOf :T1 .

:T1NOS_s a owl:Class ;
	rdfs:comment ""^^xsd:string ;
	rdfs:label "T1NOS(s) Stage Finding"^^xsd:string ;
	rdfs:subClassOf :T1NOS .

:T2 a owl:Class ;
	rdfs:label "T2 Stage Finding"^^xsd:string ;
	rdfs:comment "Tumor greater than 20 mm but not more than 50 mm in greatest dimension"  ;
	owl:equivalentClass ncit:C48724 ;
    rdfs:subClassOf :T .

:T2_m a owl:Class ;
	rdfs:comment ""^^xsd:string ;
	rdfs:label "T2(m) Stage Finding"^^xsd:string ;
	rdfs:subClassOf :T2 .

:T2_s a owl:Class ;
	rdfs:comment ""^^xsd:string ;
	rdfs:label "T2(s) Stage Finding"^^xsd:string ;
	rdfs:subClassOf :T2 .

:T2a  a owl:Class ;
	rdfs:comment ""^^xsd:string ;
	rdfs:label "T2a Stage Finding"^^xsd:string ;
	rdfs:subClassOf :T2 .

:T2a1  a owl:Class ;
	rdfs:comment ""^^xsd:string ;
	rdfs:label "T2a1 Stage Finding"^^xsd:string ;
	rdfs:subClassOf :T2a .

:T2a2  a owl:Class ;
	rdfs:comment ""^^xsd:string ;
	rdfs:label "T2a2 Stage Finding"^^xsd:string ;
	rdfs:subClassOf :T2a .

:T2b  a owl:Class ;
	rdfs:comment ""^^xsd:string ;
	rdfs:label "T2b Stage Finding"^^xsd:string ;
	rdfs:subClassOf :T2 .

:T2c  a owl:Class ;
	rdfs:comment ""^^xsd:string ;
	rdfs:label "T2c Stage Finding"^^xsd:string ;
	rdfs:subClassOf :T2 .

:T2d  a owl:Class ;
	rdfs:comment ""^^xsd:string ;
	rdfs:label "T2d Stage Finding"^^xsd:string ;
	rdfs:subClassOf :T2 .

:T2NOS a owl:Class ;
	rdfs:comment ""^^xsd:string ;
	rdfs:label "T2NOS Stage Finding"^^xsd:string ;
	rdfs:subClassOf :T2 .

:T2aNOS a owl:Class ;
	rdfs:comment ""^^xsd:string ;
	rdfs:label "T2NOS Stage Finding"^^xsd:string ;
	rdfs:subClassOf :T2a .

:T3 a owl:Class ;
	rdfs:comment "Tumor greater than 50 mm in greatest dimension"  ;
	rdfs:label "T3 Stage Finding"^^xsd:string ;
	owl:equivalentClass ncit:C48728 ;
    rdfs:subClassOf :T .

:T3_m a owl:Class ;
	rdfs:comment ""^^xsd:string ;
	rdfs:label "T3(m) Stage Finding"^^xsd:string ;
	rdfs:subClassOf :T3 .

:T3_s a owl:Class ;
	rdfs:comment ""^^xsd:string ;
	rdfs:label "T3(s) Stage Finding"^^xsd:string ;
	rdfs:subClassOf :T3 .

:T3a a owl:Class ;
	rdfs:comment ""^^xsd:string ;
	rdfs:label "T3a Stage Finding"^^xsd:string ;
	rdfs:subClassOf :T3 .

:T3b a owl:Class ;
	rdfs:comment ""^^xsd:string ;
	rdfs:label "T3b Stage Finding"^^xsd:string ;
	rdfs:subClassOf :T3 .

:T3c a owl:Class ;
	rdfs:comment ""^^xsd:string ;
	rdfs:label "T3c Stage Finding"^^xsd:string ;
	rdfs:subClassOf :T3 .

:T3d a owl:Class ;
	rdfs:comment ""^^xsd:string ;
	rdfs:label "T3d Stage Finding"^^xsd:string ;
	rdfs:subClassOf :T3 .

:T3NOS a owl:Class ;
	rdfs:comment ""^^xsd:string ;
	rdfs:label "T3NOS Stage Finding"^^xsd:string ;
	rdfs:subClassOf :T3 .

:T4 a owl:Class ;
	rdfs:label "T4 Stage Finding"^^xsd:string ;
	rdfs:comment "Tumor of any size with direct extension to the chest wall or to the skin"^^xsd:string ;
	owl:equivalentClass ncit:C48732 ;
    rdfs:subClassOf :T .

:T4a a owl:Class ;
	rdfs:label "T4a Stage Finding"^^xsd:string ;
	rdfs:comment "Extension to the chest wall"  ;
    rdfs:subClassOf :T4 ;
	owl:equivalentClass ncit:C48733 .

:T4b a owl:Class ;
	rdfs:label "T4b Stage Finding"^^xsd:string ;
	rdfs:comment "Edema, or skin ulceration of the skin, or satellite cutaneous nodules confined to the same breast"  ;
    rdfs:subClassOf :T4 ;
	owl:equivalentClass ncit:C48734 .

:T4c a owl:Class ;
	rdfs:label "T4c Stage Finding"^^xsd:string ;
	rdfs:comment "Both (T4a and T4b)"  ;
    rdfs:subClassOf :T4 ;
	owl:equivalentClass ncit:C48735 .

:T4d a owl:Class ;
	rdfs:label "T4d Stage Finding"^^xsd:string ;
	rdfs:comment "Inflammatory Carcinoma"  ;
    rdfs:subClassOf :T4 ;
	owl:equivalentClass ncit:C48736 .

:TX a owl:Class ;
	rdfs:comment "Primary tumor cannot be assessed"^^xsd:string ;
	rdfs:label "TX Stage Finding"^^xsd:string ;
	owl:equivalentClass ncit:C48737 ;
    rdfs:subClassOf :T .

:N a owl:Class ;
	rdfs:comment "Regional Lymph Node Staging Finding"^^xsd:string ;
    rdfs:label "Generic N Stage Finding"^^xsd:string ;
	owl:equivalentClass ncit:C48884 .

:N0 a owl:Class ;
    rdfs:label "N0 Stage Finding"^^xsd:string ;
    rdfs:comment "There is no cancer in nearby lymph nodes, no regional lymph node metastases"^^xsd:string ;
    owl:equivalentClass ncit:C48705 ;
    rdfs:subClassOf :N .

:N0_iPos a owl:Class ;
    rdfs:comment "ITCs only (malignant cell clusters no larger than 20 mm) in regional lymph nodes"^^xsd:string ;
    rdfs:label "N0 (i+) Stage Finding"^^xsd:string ;
    rdfs:subClassOf :N0 ;
    owl:equivalentClass ncit:C95922.

:N0_iNeg a owl:Class ;
	rdfs:comment ""^^xsd:string ;
    rdfs:label "N0 (i-) Stage Finding"^^xsd:string ;
    rdfs:subClassOf :N0 ;
    owl:equivalentClass ncit:C95921.

:N1 a owl:Class ;
	rdfs:label "N1 Stage Finding"^^xsd:string ;
	rdfs:comment "Metastasis in axillary lymph node(s), homolateral(s), mobile(s)"^^xsd:string ;
	owl:equivalentClass ncit:C48706 ;
    rdfs:subClassOf :N .

:N1a a owl:Class ;
    rdfs:comment "Metastases in 1-3 axillary lymph nodes, at least one metastasis larger than 20 cm"^^xsd:string ;
    rdfs:label "N1a Stage Finding"^^xsd:string ;
    rdfs:subClassOf :N1 ;
    owl:equivalentClass ncit:C48707. 

:N1b a owl:Class ;
    rdfs:comment "Metastases in ipsilateral internal mammary sentinel lymph nodes, excluding ITCs"^^xsd:string ;
    rdfs:label "N1b Stage Finding"^^xsd:string ;
    rdfs:subClassOf :N1 ;
    owl:equivalentClass ncit:C48708. 

:N1c a owl:Class ;
    rdfs:comment "N1a and N1b combined"^^xsd:string ;
    rdfs:label "N1c Stage Finding"^^xsd:string ;
    rdfs:subClassOf :N1 ;
    owl:equivalentClass ncit:C48709. 

:N1mi a owl:Class ;
    rdfs:comment "Micrometastases (approximately 200 cells, larger than 0.2 mm, but none larger than 2.0 mm)"^^xsd:string ;
    rdfs:label "N1mi Stage Finding"^^xsd:string ;
    rdfs:subClassOf :N1 ;
    owl:equivalentClass ncit:C95955. 

:N1NOS a owl:Class ;
	rdfs:comment ""^^xsd:string ;
    rdfs:label "N1NOS Stage Finding"^^xsd:string ;
    rdfs:subClassOf :N1 .

:N2 a owl:Class ;
	rdfs:label "N2 Stage Finding"^^xsd:string ;
	rdfs:comment "Metastasis in axillary lymph node (s), homolateral(s), fixed or clinically apparent metastasis in homolateral internal mammary lymph node(s), in the absence of clinical evidence of metastasis in Axillary lymph node(s)"  ;
	owl:equivalentClass ncit:C48786 ;
    rdfs:subClassOf :N .

:N2a a owl:Class ;
	rdfs:label "N2a Stage Finding"^^xsd:string ;
	rdfs:comment "Metastasis in axillary lymph node(s) fixed to each other or to other structures"^^xsd:string ;
    rdfs:subClassOf :N2 ;
	owl:equivalentClass ncit:C48711 .

:N2b a owl:Class ;
	rdfs:label "N2b Stage Finding"^^xsd:string ;
	rdfs:comment "Clinically apparent metastasis in internal mammary lymph node(s), in the absence of clinical evidence of metastasis in auxiliary lymph node(s)"  ;
    rdfs:subClassOf :N2 ;
	owl:equivalentClass ncit:C48712 .

:N2c a owl:Class ;
	rdfs:comment ""^^xsd:string ;
	rdfs:label "N2c Stage Finding"^^xsd:string ;
    rdfs:subClassOf :N2 ;
	owl:equivalentClass ncit:C48713 .

:N2NOS a owl:Class ;
	rdfs:comment ""^^xsd:string ;
	rdfs:label "N2NOS Stage Finding"^^xsd:string ;
    rdfs:subClassOf :N2 .

:N3 a owl:Class ;
	rdfs:label "N3 Stage Finding"^^xsd:string ;
	rdfs:comment "Metastasis in homolateral infraclavicular lymph node(s) with or without involvement of axillary lymph node(s); Or clinically apparent in homolateral internal mammary lymph node(s), in the presence of clinical evidence of metastasis in axillary lymph node(s); Or metastasis in homolateral supraclavicular lymph node(s) with or without involvement of axillary lymph node(s) or internal mammary(ies)"  ;
	owl:equivalentClass ncit:C48714 ;
    rdfs:subClassOf :N .

:N3a a owl:Class ;
	rdfs:label "N3a Stage Finding"^^xsd:string ;
	rdfs:comment "Metastases in ipsilateral infraclavicular lymph node(s)"  ;
    rdfs:subClassOf :N3 ;
	owl:equivalentClass ncit:C48715 .

:N3b a owl:Class ;
	rdfs:label "N3b Stage Finding"^^xsd:string ;
	rdfs:comment "Metastasis in internal mammary(ies) and axillary lymph nodes"  ;
    rdfs:subClassOf :N3 ;
	owl:equivalentClass ncit:C48716 .

:N3c a owl:Class ;
	rdfs:label "N3c Stage Finding"^^xsd:string ;
	rdfs:comment "Metastasis in supraclavicular lymph node(s)"  ;
    rdfs:subClassOf :N3 ;
	owl:equivalentClass ncit:C48717 .

:N3NOS a owl:Class ;
	rdfs:comment ""^^xsd:string ;
	rdfs:label "N3NOS Stage Finding"^^xsd:string ;
    rdfs:subClassOf :N3 .

:N4 a owl:Class ;
	rdfs:comment ""^^xsd:string ;
	rdfs:label "N4 Stage Finding"^^xsd:string ;
	owl:equivalentClass ncit:C96026 ;
    rdfs:subClassOf :N .

:NX a owl:Class ;
	rdfs:comment ""^^xsd:string ;
	rdfs:label "NX Stage Finding"^^xsd:string ;
	owl:equivalentClass ncit:C48718 ;
    rdfs:subClassOf :N .

:M a owl:Class ;
	rdfs:comment ""^^xsd:string ;
    rdfs:label "Generic M Stage Finding"^^xsd:string ;
	owl:equivalentClass ncit:C48883 .

:M0 a owl:Class  ;
	rdfs:label "M0 Stage Finding"^^xsd:string ;
	rdfs:comment: "No clinical or radiographic evidence of distant metastases"^^xsd:string ;
	owl:equivalentClass ncit:C48699 ;
    rdfs:subClassOf :M .

:M0_iPos a owl:Class ;
	rdfs:comment: "No clinical or radiographic evidence of distant metastasesin the presence of tumor cells or and no deposits nogreater than 0.2 mm detected microscopically or by usingmolecular techniques in circulating blood, bone marrow, orother nonregional lymph node tissue in a patient withoutsymptoms or signs of metastases"^^xsd:string ;
	rdfs:label "M0(i+) Stage Finding"^^xsd:string ;
    rdfs:subClassOf :M0 .

:M0_iNeg a owl:Class ;
	rdfs:comment ""^^xsd:string ;
	rdfs:label "M0(i-) Stage Finding"^^xsd:string ;
    rdfs:subClassOf :M0 .

:M1 a owl:Class  ;
	rdfs:comment: "Distant metastases detected by clinical and radiographicmeans (cM) and/or histologically proven metastases largerthan 0.2 mm (pM)"^^xsd:string ;
	rdfs:label "M1 Stage Finding"^^xsd:string ;
	owl:equivalentClass ncit:C48700 ;
    rdfs:subClassOf :M .

:M1a a owl:Class  ;
	rdfs:comment ""^^xsd:string ;
	rdfs:label "M1a Stage Finding"^^xsd:string ;
    rdfs:subClassOf :M1 ;
	owl:equivalentClass ncit:C48701 .

:M1b a owl:Class  ;
	rdfs:comment ""^^xsd:string ;
	rdfs:label "M1b Stage Finding"^^xsd:string ;
    rdfs:subClassOf :M1 ;
	owl:equivalentClass ncit:C48702 .

:M1c a owl:Class  ;
	rdfs:comment ""^^xsd:string ;
	rdfs:label "M1c Stage Finding"^^xsd:string ;
    rdfs:subClassOf :M1 ;
	owl:equivalentClass ncit:C48703 .

:M1NOS a owl:Class ;
	rdfs:comment ""^^xsd:string ;
	rdfs:label "M1NOS Stage Finding"^^xsd:string ;
    rdfs:subClassOf :M1 .

:MX a owl:Class  ;
	rdfs:comment ""^^xsd:string ;
	rdfs:label "MX Stage Finding"^^xsd:string ;
	owl:equivalentClass ncit:C48704 ;
    rdfs:subClassOf :M .

:Grade a owl:Class ;
	rdfs:comment "The grade of a tumour indicates what the cells look like and gives an idea of how quickly the cancer may grow and spread."^^xsd:string ;
    rdfs:label "Generic Histologic Grade Finding"^^xsd:string ;
	owl:equivalentClass ncit:C36041 .

:Grade1  a owl:Class ;
	rdfs:comment "The cells are slower-growing, and look more like normal breast tissue."^^xsd:string ;
	rdfs:label "Histologic Grade is 1"^^xsd:string ;
	owl:equivalentClass ncit:C36039 ;
    rdfs:subClassOf :Grade .

:Grade2  a owl:Class ;
	rdfs:comment "The cells are growing at a speed of and look like cells somewhere between grades 1 and 3."^^xsd:string ;
	rdfs:label "Histologic Grade is 2"^^xsd:string ;
	owl:equivalentClass ncit:C36040 ;
    rdfs:subClassOf :Grade .

:Grade3  a owl:Class ;
	rdfs:comment "The cancer cells look very different from normal cells and will probably grow and spread faster."^^xsd:string ;
	rdfs:label "Histologic Grade is 3"^^xsd:string ;
	owl:equivalentClass ncit:C36042 ;
    rdfs:subClassOf :Grade .

:Grade4  a owl:Class ;
	rdfs:comment "The cancer cells grow quickly in disorganized, irregular patterns, with many dividing to make new cancer cells."^^xsd:string ;
	rdfs:label "Histologic Grade is 4"^^xsd:string ;
	owl:equivalentClass ncit:C36045 ;
    rdfs:subClassOf :Grade .

:Receptor_Status a owl:Class;
	rdfs:comment "Status of Genetic Receptors"^^xsd:string ;
	rdfs:label "Receptor Status"^^xsd:string ;
	owl:equivalentClass ncit:C94299 .

:HER2_Pos  a owl:Class ;
	rdfs:label "HER2+"^^xsd:string ;
	rdfs:comment "Human Epidermal growth factor Receptor 2 is positive"^^xsd:string ;
	owl:equivalentClass ncit:C68748 ;
    rdfs:subClassOf :Receptor_Status .

:HER2_Neg  a owl:Class ;
	rdfs:label "HER2-"^^xsd:string ;
	rdfs:comment "Human Epidermal growth factor Receptor 2 is negative"^^xsd:string ;
	owl:equivalentClass ncit:C68749 ;
    rdfs:subClassOf :Receptor_Status .

:ER_Pos a owl:Class ;
	rdfs:label "ER+"^^xsd:string ;
	rdfs:comment "Estrogen receptor is positive"^^xsd:string ;
	owl:equivalentClass ncit:C15492 ;
    rdfs:subClassOf :Receptor_Status .

:ER_Neg a owl:Class ;
	rdfs:label "ER-"^^xsd:string ;
	rdfs:comment "Estrogen receptor is negative"^^xsd:string ;
	owl:equivalentClass ncit:C15493 ;
    rdfs:subClassOf :Receptor_Status .

:PR_Pos a owl:Class ;
	rdfs:label "PR+"^^xsd:string ;
	rdfs:comment "Progesterone receptor is positive"^^xsd:string ;
	owl:equivalentClass ncit:C15496 ;
    rdfs:subClassOf :Receptor_Status .

:PR_Neg a owl:Class ;
	rdfs:label "PR-"^^xsd:string ;
	rdfs:comment "Progesterone receptor is negative"^^xsd:string ;
	owl:equivalentClass ncit:C15497 ;
    rdfs:subClassOf :Receptor_Status .