Category Category_Description Abbreviation Definition NonCan Non-cancer drug with FDA approval Bone Bone resorption NonCan Non-cancer drug with FDA approval CardG Cardiac Glycoside NonCan Non-cancer drug with FDA approval Cath Cathartic NonCan Non-cancer drug with FDA approval Mal Malaria NonCan Non-cancer drug with FDA approval Psy Antipsychotic NonCan Non-cancer drug with FDA approval Ste Steroid PK Protein kinase inhibitor AKT Akt inhibitor PK Protein kinase inhibitor ALK ALK inhibitor PK Protein kinase inhibitor ATR ATR inhibitor PK Protein kinase inhibitor AURK Aurora kinase inhibitor PK Protein kinase inhibitor AXL Axl inhibitor PK Protein kinase inhibitor BRAF BRAF inhibitor PK Protein kinase inhibitor CDK CDK inhibitor PK Protein kinase inhibitor CHEK "CHK inhibitor (CHEK1, CHEK2)" PK Protein kinase inhibitor EGFR EGFR inhibitor. PK Protein kinase inhibitor ERBB2 ERBB2 inhibitor PK Protein kinase inhibitor ERK ERK inhibitor PK Protein kinase inhibitor FAK FAK inhibitor PK Protein kinase inhibitor FGFR FGFR inhibitor PK Protein kinase inhibitor FLT "Flt inhibitor (FLT1, FLT3, FLT4)" PK Protein kinase inhibitor FYN FYN inhibitor PK Protein kinase inhibitor GSK3A GSK3A inhibitor PK Protein kinase inhibitor GSK3B GSK3B inhibitor PK Protein kinase inhibitor IGF1R IGF1R inhibitor PK Protein kinase inhibitor JAK JAK inhibitor PK Protein kinase inhibitor KIT c-Kit inhibitor PK Protein kinase inhibitor MAP2K MAP2K (MEK) inhibitor PK Protein kinase inhibitor MAP3K MAP3K (ERK1) inhibitor PK Protein kinase inhibitor MAPK14 MAPK14 (p38) inhibitor PK Protein kinase inhibitor MAPK8 MAPK8 (JNK) inhibitor PK Protein kinase inhibitor MET MET inhibitor PK Protein kinase inhibitor MTOR MTOR inhibitor PK Protein kinase inhibitor NTRK "NTRK1, NTRK2 inhibitor" PK Protein kinase inhibitor PIK3 Phosphoinositide-3-Kinase PK Protein kinase inhibitor PRKCA PRKCA (PRK) inhibitor PK Protein kinase inhibitor PTK Protein tyrosine kinase (a gene name) PK Protein kinase inhibitor RAF RAF inhibitor PK Protein kinase inhibitor SRC SRC inhibitor PK Protein kinase inhibitor SYK SYK inhibitor PK Protein kinase inhibitor VEGF VEGF inhibitor PK Protein kinase inhibitor VEGFR VEGFR inhibitor PK Protein kinase inhibitor WEE1 WEE1 inhibitor - - A2 Alkylating at N-2 position of guanine - - A6 Alkylating at O-6 of guanine - - A7 Alkylating at N-7 position of guanine - - Ab Antibodies - - AGPAT2 AGPAT2 (LPAATB) inhibitor - - AlkAg Alkylating agent - - AM Antimetabolite - - Ang Angiogenesis - - Ant Antibiotic - - AO Antioxidant - - AP Antiprotozoal - - APH1 "APH1A, APHiB gamma secretase inhibitors" - - Apo Apoptosis inducer - - AR Androgen receptor - - BCL2 BCL2 inhibitor - - BCR-ABL BCR-ABL inhibitor - - BRD Bromodomain inhibiting - - CASP Caspase inhibitor - - CC Cell cycle - - CD133 CD133 inhibitor - - CDC7 CDC7 inhibitor - - CDH16 CDH16 (KSP) inhibitor - - CSF1R CSF1R inhibitor - - CTNNB1 Beta catenin inhibior - - CTSB Capthepsin inhibitor - - CXCR4 CXCR4 inhibitor - - CYP19A1 CYP19A1 (aromatase) inhibitor - - Db DNA binder - - DDR DNA damage repair - - Df "Antifols (impairs the function of folic acids. This inhibits production of DNA, RNA, and proteins)" - - DNMT DNA methylttransferase inhibitor - - DOT1L DOT1L inhibitor - - Dr Ribonucleotide reductase inhibitor - - Ds DNA synthesis inhibitor - - EHMT2 EHMT2 inhibitor - - EPHA4 EPHA4 inhibitor - - ER Selective Estrogen Receptor Modulators - - ERG ERG inhibitor - - ETV ETV1 inhibitor - - EZH2 EZH2 inhibitor - - FAS FAS inhibitor - - FGF FGF inhibitor - - FRS Free radical savenger - - FT Farnesel transferase inhibitor - - GARTF GARTF inhibitor - - GEMIN2 GEMIN2 (SIP1) inhibitor - - GSTP1 GSTP1 inhibitor - - GTPase "Ras, Raf and other GTPases" - - HDAC Histone deacetylase - - Hg-Smo Hedgehog-Smoothen - B catenin - - HIF1 HIF1 inhibitor - - HK2 hexokinase II inhibitor - - Ho hormone - - HSP90 "HSP90(AA1, AB1)" - - HYP Hypoxia - - IAP "XIAP, BIRC2,3,5,7,8" - - IDH1 IDH1 inhibitor - - IDNARep Inhibitor of DNA replication - - IL Interleukin - - IL6 IL6 inhibitor - - IMPDH2 IMPDH2 inhibitor - - INDO "Indoleamine 2,3-dioxygenase inhibitor" - - ITG integrin affector - - KIF11 KIF11 (Eg5) inhibitor - - KLF4 KLF4 inhibitor - - LDHA LDHA inhibitor - - LYN LYN inhibitor - - MDM2 MDM2 inhibitor - - MGLL MGLL (MAGL) inhibitor - - Mito Mitochondria; Warburg effect - - MYC c-Myc inhibitor - - NEDD8 NEDD8 (NAE) inhibitor - - NFkB Nuclear factor of kappa light polypeptide gene enhancer in B-cells - - PARP Poly(ADP-ribose)polymerase - - Pase Phosphatase inhibitor - - PD Phosphodiesterase inhibitor - - PDE6D PDE6D (PDE delta) inhibitor - - PDGFR PDGFR inhibitor - - PDK1 PDK1 inhibitor - - Pi protein synthesis inhibitor - - PIM1 PIM1 inhibitor - - PKM PKM (PKM2) inhibitor - - PLK1 PLK1 inhibitor - - PORCN porcupine inhibitor - - PPARG PPARG inhibitor - - PSM proteasome inhibitor - - RAD51 RAD51 inhibitor - - RAS RAS inhibitor - - RHO RHO inhibitor - - ROS1 ROS1 inhibitor - - RP Radioprotectant - - Rs RNA synthesis inhibitor - - RXR Retinoic acid receptor - - SETD8 SETD8 (N-Lysine Methyltransferase) inhibitor - - SMO SMO inhibitor - - STAT "STAT(3,5) inhibitor" - - STK Serine threonine kinase - - T1 Topoisomerase 1 inhibitor - - T2 Topoisomerase 2 inhibitor - - TEK TEK (TIE2) inhibitor - - TGFB1 TGFB1 inhibitor - - TLR8 TLR8 inhibitor - - TNKS TNKS inhibitor - - Tu Tubulin affecting - - TXNRD "TXNRD (1,2,3) inhibitor" - - Wnt Wingless-type MMTV integration site family (WNT) inhibitor - - YK Tyrosine kinase inhibitor