{ "metadata": { "name": "", "signature": "sha256:890eab72cd8bd6ac7a92b9fafe531cf3cccbd05303baa420516035fb771f5682" }, "nbformat": 3, "nbformat_minor": 0, "worksheets": [ { "cells": [ { "cell_type": "heading", "level": 1, "metadata": {}, "source": [ "myChEMBL iPython Notebook Tutorial" ] }, { "cell_type": "heading", "level": 2, "metadata": {}, "source": [ "A Chemoinformatics taster using the RDKit toolkit and cartridge, the ChEMBL database and Pandas" ] }, { "cell_type": "heading", "level": 3, "metadata": {}, "source": [ "myChEMBL team, ChEMBL group, EMBL-EBI." ] }, { "cell_type": "heading", "level": 4, "metadata": {}, "source": [ "myChEMBL publication (Open Access):\n", "http://bioinformatics.oxfordjournals.org/content/early/2013/11/20/bioinformatics.btt666.abstract" ] }, { "cell_type": "heading", "level": 4, "metadata": {}, "source": [ "Start with something relatively easy" ] }, { "cell_type": "code", "collapsed": false, "input": [ "print 'Hello World!'" ], "language": "python", "metadata": {}, "outputs": [ { "output_type": "stream", "stream": "stdout", "text": [ "Hello World!\n" ] } ], "prompt_number": 1 }, { "cell_type": "code", "collapsed": false, "input": [ "1+4" ], "language": "python", "metadata": {}, "outputs": [ { "metadata": {}, "output_type": "pyout", "prompt_number": 2, "text": [ "5" ] } ], "prompt_number": 2 }, { "cell_type": "heading", "level": 4, "metadata": {}, "source": [ "Import RDKit libraries" ] }, { "cell_type": "code", "collapsed": false, "input": [ "from rdkit.Chem import AllChem as Chem\n", "from rdkit.Chem.Draw import IPythonConsole\n", "from rdkit.Chem import Descriptors\n", "from rdkit import DataStructs" ], "language": "python", "metadata": {}, "outputs": [], "prompt_number": 3 }, { "cell_type": "heading", "level": 3, "metadata": {}, "source": [ "Simple RDKit stuff - Molecules, descriptors and similarity" ] }, { "cell_type": "heading", "level": 4, "metadata": {}, "source": [ "Molecule from SMILES" ] }, { "cell_type": "code", "collapsed": false, "input": [ "smi = 'CCCc1nn(C)c2C(=O)NC(=Nc12)c3cc(ccc3OCC)S(=O)(=O)N4CCN(C)CC4' #sildenafil\n", "m = Chem.MolFromSmiles(smi)" ], "language": "python", "metadata": {}, "outputs": [], "prompt_number": 4 }, { "cell_type": "code", "collapsed": false, "input": [ "m" ], "language": "python", "metadata": {}, "outputs": [ { "metadata": {}, "output_type": "pyout", "png": 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"prompt_number": 5, "text": [ "" ] } ], "prompt_number": 5 }, { "cell_type": "heading", "level": 4, "metadata": {}, "source": [ "Simple descriptors" ] }, { "cell_type": "code", "collapsed": false, "input": [ "Descriptors.MolWt(m)" ], "language": "python", "metadata": {}, "outputs": [ { "metadata": {}, "output_type": "pyout", "prompt_number": 6, "text": [ "474.5870000000004" ] } ], "prompt_number": 6 }, { "cell_type": "code", "collapsed": false, "input": [ "Descriptors.TPSA(m)" ], "language": "python", "metadata": {}, "outputs": [ { "metadata": {}, "output_type": "pyout", "prompt_number": 7, "text": [ "113.41999999999999" ] } ], "prompt_number": 7 }, { "cell_type": "code", "collapsed": false, "input": [ "Descriptors.RingCount(m)" ], "language": "python", "metadata": {}, "outputs": [ { "metadata": {}, "output_type": "pyout", "prompt_number": 8, "text": [ "4" ] } ], "prompt_number": 8 }, { "cell_type": "heading", "level": 4, "metadata": {}, "source": [ "Output to various text formats" ] }, { "cell_type": "code", "collapsed": false, "input": [ "Chem.MolToSmiles(m, True)" ], "language": "python", "metadata": {}, "outputs": [ { "metadata": {}, "output_type": "pyout", "prompt_number": 9, "text": [ "'CCCc1nn(C)c2c1nc(-c1cc(S(=O)(=O)N3CCN(C)CC3)ccc1OCC)[nH]c2=O'" ] } ], "prompt_number": 9 }, { "cell_type": "code", "collapsed": false, "input": [ "Chem.MolToInchi(m)" ], "language": "python", "metadata": {}, "outputs": [ { "metadata": {}, "output_type": "pyout", "prompt_number": 10, "text": [ "'InChI=1S/C22H30N6O4S/c1-5-7-17-19-20(27(4)25-17)22(29)24-21(23-19)16-14-15(8-9-18(16)32-6-2)33(30,31)28-12-10-26(3)11-13-28/h8-9,14H,5-7,10-13H2,1-4H3,(H,23,24,29)'" ] } ], "prompt_number": 10 }, { "cell_type": "code", "collapsed": false, "input": [ "print Chem.MolToMolBlock(m)" ], "language": "python", "metadata": {}, "outputs": [ { "output_type": "stream", "stream": "stdout", "text": [ "\n", " RDKit \n", "\n", " 33 36 0 0 0 0 0 0 0 0999 V2000\n", " 0.0000 0.0000 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0\n", " 0.0000 0.0000 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0\n", " 0.0000 0.0000 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0\n", " 0.0000 0.0000 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0\n", " 0.0000 0.0000 0.0000 N 0 0 0 0 0 0 0 0 0 0 0 0\n", " 0.0000 0.0000 0.0000 N 0 0 0 0 0 0 0 0 0 0 0 0\n", " 0.0000 0.0000 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0\n", " 0.0000 0.0000 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0\n", " 0.0000 0.0000 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0\n", " 0.0000 0.0000 0.0000 O 0 0 0 0 0 0 0 0 0 0 0 0\n", " 0.0000 0.0000 0.0000 N 0 0 0 0 0 0 0 0 0 0 0 0\n", " 0.0000 0.0000 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0\n", " 0.0000 0.0000 0.0000 N 0 0 0 0 0 0 0 0 0 0 0 0\n", " 0.0000 0.0000 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0\n", " 0.0000 0.0000 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0\n", " 0.0000 0.0000 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0\n", " 0.0000 0.0000 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0\n", " 0.0000 0.0000 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0\n", " 0.0000 0.0000 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0\n", " 0.0000 0.0000 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0\n", " 0.0000 0.0000 0.0000 O 0 0 0 0 0 0 0 0 0 0 0 0\n", " 0.0000 0.0000 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0\n", " 0.0000 0.0000 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0\n", " 0.0000 0.0000 0.0000 S 0 0 0 0 0 0 0 0 0 0 0 0\n", " 0.0000 0.0000 0.0000 O 0 0 0 0 0 0 0 0 0 0 0 0\n", " 0.0000 0.0000 0.0000 O 0 0 0 0 0 0 0 0 0 0 0 0\n", " 0.0000 0.0000 0.0000 N 0 0 0 0 0 0 0 0 0 0 0 0\n", " 0.0000 0.0000 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0\n", " 0.0000 0.0000 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0\n", " 0.0000 0.0000 0.0000 N 0 0 0 0 0 0 0 0 0 0 0 0\n", " 0.0000 0.0000 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0\n", " 0.0000 0.0000 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0\n", " 0.0000 0.0000 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0\n", " 1 2 1 0\n", " 2 3 1 0\n", " 3 4 1 0\n", " 4 5 2 0\n", " 5 6 1 0\n", " 6 7 1 0\n", " 6 8 1 0\n", " 8 9 1 0\n", " 9 10 2 0\n", " 9 11 1 0\n", " 11 12 1 0\n", " 12 13 2 0\n", " 13 14 1 0\n", " 12 15 1 0\n", " 15 16 2 0\n", " 16 17 1 0\n", " 17 18 2 0\n", " 18 19 1 0\n", " 19 20 2 0\n", " 20 21 1 0\n", " 21 22 1 0\n", " 22 23 1 0\n", " 17 24 1 0\n", " 24 25 2 0\n", " 24 26 2 0\n", " 24 27 1 0\n", " 27 28 1 0\n", " 28 29 1 0\n", " 29 30 1 0\n", " 30 31 1 0\n", " 30 32 1 0\n", " 32 33 1 0\n", " 14 4 1 0\n", " 14 8 2 0\n", " 20 15 1 0\n", " 33 27 1 0\n", "M END\n", "\n" ] } ], "prompt_number": 11 }, { "cell_type": "code", "collapsed": false, "input": [ "# Let's add 2D coordinates...\n", "Chem.Compute2DCoords(m)" ], "language": "python", "metadata": {}, "outputs": [ { "metadata": {}, "output_type": "pyout", "prompt_number": 12, "text": [ "0" ] } ], "prompt_number": 12 }, { "cell_type": "code", "collapsed": false, "input": [ "# The mol block has been updated\n", "print Chem.MolToMolBlock(m)" ], "language": "python", "metadata": {}, "outputs": [ { "output_type": "stream", "stream": "stdout", "text": [ "\n", " RDKit 2D\n", "\n", " 33 36 0 0 0 0 0 0 0 0999 V2000\n", " -8.2094 2.2189 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0\n", " -7.5208 0.8863 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0\n", " -6.0224 0.8163 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0\n", " -5.3338 -0.5163 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0\n", " -6.0072 -1.8566 0.0000 N 0 0 0 0 0 0 0 0 0 0 0 0\n", " -4.9405 -2.9112 0.0000 N 0 0 0 0 0 0 0 0 0 0 0 0\n", " -5.1666 -4.3941 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0\n", " -3.6079 -2.2226 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0\n", " -2.2044 -2.7522 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0\n", " -1.9613 -4.2323 0.0000 O 0 0 0 0 0 0 0 0 0 0 0 0\n", " -1.0441 -1.8015 0.0000 N 0 0 0 0 0 0 0 0 0 0 0 0\n", " -1.2872 -0.3214 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0\n", " -2.6907 0.2082 0.0000 N 0 0 0 0 0 0 0 0 0 0 0 0\n", " -3.8510 -0.7424 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0\n", " -0.1269 0.6292 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0\n", " 1.2765 0.0997 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0\n", " 2.4368 1.0503 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0\n", " 2.1937 2.5305 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0\n", " 0.7903 3.0600 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0\n", " -0.3700 2.1094 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0\n", " -1.7734 2.6390 0.0000 O 0 0 0 0 0 0 0 0 0 0 0 0\n", " -2.0166 4.1191 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0\n", " -3.4200 4.6487 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0\n", " 3.8402 0.5208 0.0000 S 0 0 0 0 0 0 0 0 0 0 0 0\n", " 3.3107 -0.8826 0.0000 O 0 0 0 0 0 0 0 0 0 0 0 0\n", " 4.3698 1.9242 0.0000 O 0 0 0 0 0 0 0 0 0 0 0 0\n", " 5.2436 -0.0088 0.0000 N 0 0 0 0 0 0 0 0 0 0 0 0\n", " 5.4867 -1.4889 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0\n", " 6.8902 -2.0185 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0\n", " 8.0505 -1.0679 0.0000 N 0 0 0 0 0 0 0 0 0 0 0 0\n", " 9.4539 -1.5974 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0\n", " 7.8074 0.4123 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0\n", " 6.4039 0.9418 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0\n", " 1 2 1 0\n", " 2 3 1 0\n", " 3 4 1 0\n", " 4 5 2 0\n", " 5 6 1 0\n", " 6 7 1 0\n", " 6 8 1 0\n", " 8 9 1 0\n", " 9 10 2 0\n", " 9 11 1 0\n", " 11 12 1 0\n", " 12 13 2 0\n", " 13 14 1 0\n", " 12 15 1 0\n", " 15 16 2 0\n", " 16 17 1 0\n", " 17 18 2 0\n", " 18 19 1 0\n", " 19 20 2 0\n", " 20 21 1 0\n", " 21 22 1 0\n", " 22 23 1 0\n", " 17 24 1 0\n", " 24 25 2 0\n", " 24 26 2 0\n", " 24 27 1 0\n", " 27 28 1 0\n", " 28 29 1 0\n", " 29 30 1 0\n", " 30 31 1 0\n", " 30 32 1 0\n", " 32 33 1 0\n", " 14 4 1 0\n", " 14 8 2 0\n", " 20 15 1 0\n", " 33 27 1 0\n", "M END\n", "\n" ] } ], "prompt_number": 13 }, { "cell_type": "heading", "level": 4, "metadata": {}, "source": [ "Fingerprints and similarity" ] }, { "cell_type": "code", "collapsed": false, "input": [ "fp = Chem.GetMorganFingerprintAsBitVect(m,2,nBits=2048)" ], "language": "python", "metadata": {}, "outputs": [], "prompt_number": 14 }, { "cell_type": "code", "collapsed": false, "input": [ "fp.ToBitString()" ], "language": "python", "metadata": {}, "outputs": [ { "metadata": {}, "output_type": "pyout", "prompt_number": 15, "text": [ "'00000000000000100000000000000000000000000000000000000000000000000000000001000000100000000000001000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000010000000000000000000000000000010000000000000000000000000000001000000000000000000000000010000000000000000000100001000000000000000000000000000000101000010000000010000000000010000000000000000001000000000000000000000000000100000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000010000000000000000000000000000000000000010000000000000000000010000000000000000000000000000000000000000000000000000000000000000100000000000000000000010000000000000000000000100000000000000000001000000000000000000000000000000000010000001000000000000000000000010000000000000100000100000000000000000000000000000000000000000000000000000000000000000000000000100000000000000000000000000000000000000000000000000100000000100000000000000000000000000000000000000000100000000000000000000000000010000000000000000000000000000000000000000000000000001000000000000000000000000000000000000000000000001000000001000000000000000000000000000000100000000000000000000000000000000000000000000000000000000000000000000000000000000000000000010100001000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000010000000000000000000000000000000000000000000000000000000000010000000000010000000000000000000000010001000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001000100000000000000000000000000000000000000000000000000000000000000100000000000000000000000000000000000000000000000101001000000000000000100001000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001000000000000000001000100000000000000000001000000000000000000000000000000000000000000000000000010000010000000000000100000000000000000000000000000000000000000000000000000000000000000000000000000'" ] } ], "prompt_number": 15 }, { "cell_type": "code", "collapsed": false, "input": [ "fp.GetNumOnBits()" ], "language": "python", "metadata": {}, "outputs": [ { "metadata": {}, "output_type": "pyout", "prompt_number": 16, "text": [ "61" ] } ], "prompt_number": 16 }, { "cell_type": "code", "collapsed": false, "input": [ "fp.GetNumBits()" ], "language": "python", "metadata": {}, "outputs": [ { "metadata": {}, "output_type": "pyout", "prompt_number": 17, "text": [ "2048" ] } ], "prompt_number": 17 }, { "cell_type": "code", "collapsed": false, "input": [ "smi2 = 'CCCc1nc(C)c2C(=O)N=C(Nn12)c3cc(ccc3OCC)S(=O)(=O)N4CCN(CC)CC4' #vardenafil\n", "m2 = Chem.MolFromSmiles(smi2)" ], "language": "python", "metadata": {}, "outputs": [], "prompt_number": 18 }, { "cell_type": "code", "collapsed": false, "input": [ "fp2 = Chem.GetMorganFingerprintAsBitVect(m2, 2, nBits=2048)" ], "language": "python", "metadata": {}, "outputs": [], "prompt_number": 19 }, { "cell_type": "code", "collapsed": false, "input": [ "m2" ], "language": "python", "metadata": {}, "outputs": [ { "metadata": {}, "output_type": "pyout", "png": 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Xrl1NZ1kS0lIUhKRVngwDbXl89xFDQ0P07dtX588JHz7kh4IbPb4Am+hO49Dp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\ngsaE2cfo01wAAAAASUVORK5CYII=\n", "prompt_number": 21, "text": [ "" ] } ], "prompt_number": 21 }, { "cell_type": "code", "collapsed": false, "input": [ "DataStructs.TanimotoSimilarity(fp,fp2)" ], "language": "python", "metadata": {}, "outputs": [ { "metadata": {}, "output_type": "pyout", "prompt_number": 22, "text": [ "0.5" ] } ], "prompt_number": 22 }, { "cell_type": "heading", "level": 4, "metadata": {}, "source": [ "Similarity Maps" ] }, { "cell_type": "code", "collapsed": false, "input": [ "from rdkit.Chem.Draw import SimilarityMaps\n", "SimilarityMaps.GetSimilarityMapForFingerprint(m2, m, SimilarityMaps.GetMorganFingerprint)" ], "language": "python", "metadata": {}, "outputs": [ { "metadata": {}, "output_type": "pyout", "prompt_number": 23, "text": [ "(, 0.14414414414414412)" ] }, { "metadata": {}, "output_type": "display_data", "png": 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Dq8+8i2lYrFq9EqVNDOX2BNYotEovnZZb0vzVx2WxJVsJdSE+aRKgX3iFVhrxrluSLom5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"text": [ "" ] } ], "prompt_number": 23 }, { "cell_type": "heading", "level": 4, "metadata": {}, "source": [ "For more RDKit examples: http://www.rdkit.org/docs/GettingStartedInPython.html" ] }, { "cell_type": "heading", "level": 3, "metadata": {}, "source": [ "Using the RDKit database cartridge in myChEMBL" ] }, { "cell_type": "heading", "level": 4, "metadata": {}, "source": [ "SMARTS-based substructure search" ] }, { "cell_type": "code", "collapsed": false, "input": [ "sma = 'C1C[!#1!#6]1' #oxirane or aziridine" ], "language": "python", "metadata": {}, "outputs": [], "prompt_number": 24 }, { "cell_type": "code", "collapsed": false, "input": [ "from IPython.display import Image\n", "from urllib import quote_plus" ], "language": "python", "metadata": {}, "outputs": [], "prompt_number": 25 }, { "cell_type": "code", "collapsed": false, "input": [ "Image(url='http://www.smartsview.de/smartsview/auto/png/1/dynamic/{0}'.format(quote_plus(sma)))" ], "language": "python", "metadata": {}, "outputs": [ { "html": [ "" ], "metadata": {}, "output_type": "pyout", "prompt_number": 26, "text": [ "" ] } ], "prompt_number": 26 }, { "cell_type": "code", "collapsed": false, "input": [ "import psycopg2" ], "language": "python", "metadata": {}, "outputs": [], "prompt_number": 27 }, { "cell_type": "code", "collapsed": false, "input": [ "conn = psycopg2.connect(port=5432, user='chembl', dbname='chembl_19')" ], "language": "python", "metadata": {}, "outputs": [], "prompt_number": 28 }, { "cell_type": "code", "collapsed": false, "input": [ "cur = conn.cursor()" ], "language": "python", "metadata": {}, "outputs": [], "prompt_number": 29 }, { "cell_type": "code", "collapsed": false, "input": [ "sql1 = \"\"\"\n", "SELECT mr.*, md.chembl_id, cp.full_mwt, cp.alogp\n", "from mols_rdkit mr, molecule_dictionary md, compound_properties cp\n", "where\n", "mr.m @> 'C1C[!#1!#6]1'::qmol\n", "and\n", "mr.molregno = md.molregno\n", "and\n", "md.molregno = cp.molregno\n", "limit 100\n", "\"\"\"" ], "language": "python", "metadata": {}, "outputs": [], "prompt_number": 30 }, { "cell_type": "code", "collapsed": false, "input": [ "cur.execute(sql1)" ], "language": "python", "metadata": {}, "outputs": [], "prompt_number": 31 }, { "cell_type": "code", "collapsed": false, "input": [ "for c in cur: print c" ], "language": "python", "metadata": {}, "outputs": [ { "output_type": "stream", "stream": "stdout", "text": [ "(504141, 'CC(=O)O[C@H]1C[C@@H]2O[C@]2(C)[C@@H]2[C@@H](O)[C@]34O[C@]3(C)C(=O)O[C@H]4C=C(C)CC[C@@H](OC(C)=O)[C@@]12C', 'CHEMBL465387', Decimal('464.51'), Decimal('0.65'))\n", "(511156, 'CC[C@@]12CC(C(=O)OC)=C3Nc4cc(OC)c(O)cc4[C@@]34CCN(C(=O)[C@@H]3O[C@@H]31)[C@H]42', 'CHEMBL525919', Decimal('412.44'), Decimal('1.06'))\n", "(1558653, 'C=C(C)[C@]12C[C@@H](C)[C@]34O[C@@]5(CCCCCCC[C@@H](C)[C@@H]6[C@@H]3[C@@](O)(C(=O)[C@H]6C)[C@H](O)[C@@]3(CO)O[C@H]3[C@H]4[C@H]1O5)O2', 'CHEMBL2376812', Decimal('532.67'), Decimal('3.60'))\n", "(507693, 'O=C1c2c(O)ccc3c2[C@@]2(Oc4cccc5c4[C@](O3)(O2)[C@H](O)C[C@@H]5O)[C@@H]2O[C@H]12', 'CHEMBL488950', Decimal('382.32'), Decimal('1.01'))\n", "(507695, 'O=C1CC[C@]23Oc4ccc(O)c5c4[C@](Oc4cccc1c42)(O3)[C@@H]1O[C@@H]1[C@@H]5O', 'CHEMBL485874', Decimal('366.32'), Decimal('1.66'))\n", "(507740, 'CO[C@@H]1CC(=O)c2cccc3c2[C@@]12Oc1ccc(O)c4c1[C@](O3)(O2)[C@@H]1O[C@@H]1[C@@H]4O', 'CHEMBL487724', Decimal('396.35'), Decimal('1.50'))\n", "(1558663, 'C=C(C)[C@]12C[C@@H](C)[C@@]34OC(c5ccccc5)(OC1[C@@H]3[C@@H]1O[C@]1(COC(=O)c1ccccc1)[C@@H](O)[C@@]1(O)[C@H]4C[C@H](C)[C@@H]1O)O2', 'CHEMBL2376822', Decimal('590.66'), Decimal('3.77'))\n", "(1573582, 'CC[C@H]1C[C@@H]2CN3CCc4c5ccc(OC)c([C@H]6C[C@@H]7[C@]8(O[C@@H]8C)[C@@H]8OC[C@]7(C(=O)OC)[C@H](Cc7c9ccccc9[nH]c76)N8C)c5[nH]c4[C@](C(=O)OC)(C2)[C@H]13', 'CHEMBL2409162', Decimal('748.91'), Decimal('6.27'))\n", "(664813, 'Cn1cc(NC(=O)c2cc(NC(=O)c3cc(NC(=O)c4cc(NC(=O)C5CO5)cn4C)cn3C)cn2C)cc1C(=O)NCCC(=N)N', 'CHEMBL1190863', Decimal('645.67'), Decimal('-0.28'))\n", "(686885, 'CC(=O)OCC1=CO[C@@H](OC(C)=O)[C@H]2[C@@H]1C[C@H](OC(=O)CC(C)C)[C@]21CO1', 'CHEMBL1215026', Decimal('382.40'), Decimal('0.93'))\n", "(686886, 'CC(=O)OCC1=CO[C@@H](OC(=O)CC(C)C)[C@H]2[C@@H]1C[C@H](OC(C)=O)[C@]21CO1', 'CHEMBL1215027', Decimal('382.40'), Decimal('0.93'))\n", "(698093, 'c1ccc([C@@H]2CO2)cc1', 'CHEMBL1235743', Decimal('120.15'), Decimal('1.48'))\n", "(1523873, 'CN(C)CCn1nc2c3c1ccc(NCCCCN1CC1)c3C(=O)c1ccncc1-2', 'CHEMBL2334226', Decimal('404.51'), Decimal('2.60'))\n", "(628080, 'C=C(C)[C@@H]1CC(=O)C[C@H]2O[C@](C)(CC2=O)C[C@H]2OC(=O)[C@@]3(O[C@H]23)[C@@H](O)C1', 'CHEMBL1094859', Decimal('364.39'), Decimal('0.16'))\n", "(643623, 'O=C(O)[C@H]1O[C@@H]1c1ccc(F)cc1', 'CHEMBL1162084', Decimal('182.15'), Decimal('1.30'))\n", "(643624, 'O=C(O)[C@H]1O[C@@H]1c1ccccc1', 'CHEMBL1162085', Decimal('164.16'), Decimal('1.10'))\n", "(1573320, 'NS(=O)(=O)c1ccc(-n2cc(CNC(=O)[C@H](Cc3cscn3)NC(=O)[C@H]3O[C@@H]3C(=O)O)nn2)cc1', 'CHEMBL2408902', Decimal('521.53'), Decimal('-1.36'))\n", "(1573342, 'CC(C)C[C@H](NC(=O)[C@H]1O[C@@H]1C(=O)O)C(=O)Nc1c(F)cccc1F', 'CHEMBL2408924', Decimal('356.32'), Decimal('1.44'))\n", "(593645, 'COc1cc(C(=O)[C@H]2O[C@@H]2c2cc(OC)c(OC)c(OC)c2)cc(OC)c1OC', 'CHEMBL596033', Decimal('404.41'), Decimal('2.77'))\n", "(593623, 'COc1cc(C(=O)[C@H]2O[C@@H]2c2ccc(C)cc2)cc(OC)c1OC', 'CHEMBL594612', Decimal('328.36'), Decimal('3.31'))\n", "(593568, 'Cc1ccc(C(=O)[C@H]2O[C@@H]2c2ccc(C)cc2)cc1', 'CHEMBL593208', Decimal('252.31'), Decimal('3.84'))\n", "(1573333, 'O=C(O)[C@@H]1O[C@H]1C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)Nc1nc2ccc(F)cc2s1', 'CHEMBL2408915', Decimal('419.39'), Decimal('0.22'))\n", "(1576269, 'N#Cc1c(Cl)nc(SCC2CO2)nc1-c1ccccc1', 'CHEMBL2415028', Decimal('303.77'), Decimal('3.53'))\n", "(501263, 'CC(C)CCC[C@@H](C)[C@H]1CC[C@H]2[C@@H]3C[C@@H]4O[C@@]45C[C@@H](O)CC[C@]5(C)[C@H]3CC[C@]12C', 'CHEMBL497438', Decimal('402.65'), Decimal('6.22'))\n", "(501490, 'CC(C)CCC[C@@H](C)[C@H]1CC[C@H]2[C@@H]3[C@@H]4O[C@@]45C[C@@H](O)CC[C@]5(C)[C@H]3CC[C@]12C', 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Decimal('3.11'))\n", "(1545943, 'Cc1c(OCCN2CC2)cc(C(=O)N[C@@H]2C(=O)N[C@H](C(C)C)C(=O)N3CCC[C@H]3C(=O)N(C)CC(=O)N(C)[C@@H](C(C)C)C(=O)O[C@@H]2C)c2nc3c(C(=O)N[C@@H]4C(=O)N[C@H](C(C)C)C(=O)N5CCC[C@H]5C(=O)N(C)CC(=O)N(C)[C@@H](C(C)C)C(=O)O[C@@H]4C)c(N)c(=O)c(C)c-3oc12', 'CHEMBL2371492', Decimal('1340.52'), None)\n", "(701554, 'C[C@H]1C(=O)C=CC(C)(C)C[C@@H]2O[C@]2(C)CC[C@H]1NCc1ccccc1', 'CHEMBL1242326', Decimal('341.49'), Decimal('3.88'))\n", "(701553, 'CCCCN[C@@H]1CC[C@@]2(C)O[C@H]2CC(C)(C)C=CC(=O)[C@@H]1C', 'CHEMBL1242325', Decimal('307.47'), Decimal('3.63'))\n", "(578137, 'CO[C@@H]1[C@H](OC(=O)N[C@H]2CN3CCC2CC3)CC[C@]2(CO2)[C@H]1[C@@]1(C)O[C@@H]1CC=C(C)C', 'CHEMBL578806', Decimal('434.57'), Decimal('2.31'))\n", "(578138, 'CO[C@@H]1[C@H](OC(=O)N[C@@H](C(=O)Nc2cccc(C(=O)O)c2)C(C)C)CC[C@]2(CO2)[C@H]1[C@@]1(C)O[C@@H]1CC=C(C)C', 'CHEMBL585936', Decimal('544.64'), Decimal('3.36'))\n", "(580238, 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'C=C1C[C@@H]2CC[C@@]34C[C@H]5O[C@@H]6[C@@H](O[C@H]7CC[C@H](CC(=O)C[C@@H]8[C@@H](OC)[C@@H](C[C@@H](CN9C[C@@H]9C)OC)O[C@H]8C[C@H]8O[C@@H](CC[C@@H]1O2)C[C@@H](C)C8=C)O[C@@H]7[C@@H]6O3)[C@H]5O4', 'CHEMBL1683598', Decimal('783.99'), Decimal('2.54'))\n", "(1063555, 'CC(=O)O[C@@H]1C[C@@]23C[C@@]24CC[C@H](O[C@@H]2OC[C@@H](O)[C@H](O)[C@H]2O)C(C)(C)[C@@H]4CC[C@H]3[C@]2(C)C[C@@H]3O[C@]4(C[C@@H](C)[C@@H]3[C@@]12C)O[C@H](O)[C@@]1(C)O[C@@H]14', 'CHEMBL1651281', Decimal('676.83'), Decimal('1.81'))\n", "(1164261, 'C[C@H]1CC[C@@H]2[C@@H](OC(=O)[C@]23CN3c2ccccc2[N+](=O)[O-])[C@]2(C)C(=O)C=C[C@@]12O', 'CHEMBL1806585', Decimal('398.41'), Decimal('2.56'))\n", "(1217498, 'CC1(C)O[C@H]2O[C@H]([C@H](O)CO/N=C3\\\\[C@H]4O[C@H]4[C@@H](O)[C@H]4[C@@H]3CCn3c(=O)n(-c5ccccc5)c(=O)n34)[C@H](O)[C@H]2O1', 'CHEMBL1876927', Decimal('546.53'), Decimal('-1.24'))\n", "(1077476, 'C=C(C)[C@H]1CC(=O)[C@]2(C)CC=C(C)CC[C@@H]3O[C@@]3(C)CC[C@@H]12', 'CHEMBL1689080', Decimal('302.45'), Decimal('4.34'))\n", "(1564392, 'CCCC1OC1S(=O)(=O)c1ccccc1', 'CHEMBL2387614', Decimal('226.29'), Decimal('2.60'))\n", "(1548035, 'CCCNC(=O)OC[C@H]1O[C@@H](CCO/N=C2/[C@H]3O[C@@H]3[C@@H](O)[C@H]3[C@H]2CCn2c(=O)n(-c4ccccc4)c(=O)n23)C=C[C@@H]1Oc1ccc(OC)cc1', 'CHEMBL2373584', Decimal('691.73'), Decimal('2.81'))\n", "(1277391, 'CCCCCCCCCCCCC(=O)/C=C/CCCOC[C@H]1CO1', 'CHEMBL1946010', Decimal('338.52'), Decimal('6.04'))\n", "(1614132, 'CCCCN(C)C(=O)O[C@@H](C)/C=C\\\\C(=O)N[C@H]1CO[C@@H](C/C=C(C)/C=C/[C@@H]2C[C@]3(CO3)CC(C)(C)O2)OC1', 'CHEMBL3108937', Decimal('534.68'), Decimal('2.90'))\n", "(1614136, 'CC(/C=C/[C@@H]1C[C@]2(CO2)CC(C)(C)O1)=C\\\\C[C@H]1OC[C@@H](NC(=O)/C=C\\\\[C@H](C)OC(=O)N2CCCCC2)CO1', 'CHEMBL3108941', Decimal('532.67'), Decimal('2.48'))\n", "(1059753, 'O=C(/C=C/c1ccc(OCC2CS2)cc1)c1ccc(OCC2CS2)cc1', 'CHEMBL1644751', Decimal('384.51'), Decimal('4.59'))\n", "(1059755, 'COc1ccc(/C=C/C(=O)c2ccc(OCC3CS3)cc2OCC2CS2)cc1', 'CHEMBL1644753', Decimal('414.54'), Decimal('4.58'))\n", "(1063269, 'CC1(C)O[C@H]1COc1cc(=O)oc2cc3occc3cc12', 'CHEMBL1651087', Decimal('286.28'), Decimal('2.19'))\n", "(1572813, 'CC(=O)O[C@H]1[C@H]2O[C@H]2C[C@@H]2[C@@H](O)C(=O)[C@H]3[C@@H]4[C@@H](O)[C@@H]5[C@H]([C@H](C)C=C6OC(=O)[C@@](C)(O)[C@@]65C)[C@@]4(C)[C@@H](OC(C)=O)[C@@H](OC(C)=O)[C@@H]3[C@@]12C', 'CHEMBL2408400', Decimal('660.71'), Decimal('-0.52'))\n", "(1300641, 'CC(O)CCOP(=O)(N(CCCl)CCCl)N1CC1', 'CHEMBL1979350', Decimal('319.17'), Decimal('0.19'))\n", "(1573338, 'CC(C)C[C@H](NC(=O)[C@@H]1O[C@H]1C(=O)O)C(=O)Nc1nc(-c2ccc(F)cc2)cs1', 'CHEMBL2408920', Decimal('421.44'), Decimal('2.18'))\n", "(1579396, 'CC[C@H](O)[C@@H](C)[C@H]1O[C@@H]1C[C@H](C)/C=C/C=C(\\\\C)[C@H]1OC(=O)CCCCCCC=C[C@@H]1C', 'CHEMBL2420604', Decimal('432.64'), Decimal('6.40'))\n", "(998031, 'O=C(Cn1c2ccccc2n(CC2CS2)c1=O)N1CCCCC1', 'CHEMBL1574147', Decimal('331.43'), Decimal('1.75'))\n", "(1226861, 'O=C1C=CC(O)C2(CO)OC12', 'CHEMBL1886290', Decimal('156.14'), Decimal('-1.21'))\n" ] } ], "prompt_number": 32 }, { "cell_type": "heading", "level": 4, "metadata": {}, "source": [ "Similarity-based (NN) search" ] }, { "cell_type": "code", "collapsed": false, "input": [ "smi = 'CCCc1nn(C)c2C(=O)NC(=Nc12)c3cc(ccc3OCC)S(=O)(=O)N4CCN(C)CC4' #sildenafil" ], "language": "python", "metadata": {}, "outputs": [], "prompt_number": 33 }, { "cell_type": "code", "collapsed": false, "input": [ "sql2 = \"\"\"\n", "select molregno,m as smiles,tanimoto_sml(morganbv_fp('CCCc1nn(C)c2C(=O)NC(=Nc12)c3cc(ccc3OCC)S(=O)(=O)N4CCN(C)CC4'::mol),mfp2) as similarity\n", "from fps_rdkit join mols_rdkit using (molregno)\n", "where morganbv_fp('CCCc1nn(C)c2C(=O)NC(=Nc12)c3cc(ccc3OCC)S(=O)(=O)N4CCN(C)CC4'::mol)%mfp2\n", "order by morganbv_fp('CCCc1nn(C)c2C(=O)NC(=Nc12)c3cc(ccc3OCC)S(=O)(=O)N4CCN(C)CC4'::mol)<%>mfp2;\n", "\"\"\"\n" ], "language": "python", "metadata": {}, "outputs": [], "prompt_number": 34 }, { "cell_type": "code", "collapsed": false, "input": [ "cur.execute(sql2)" ], "language": "python", "metadata": {}, "outputs": [], "prompt_number": 35 }, { "cell_type": "code", "collapsed": false, "input": [ "for c in cur: print c" ], "language": "python", "metadata": {}, "outputs": [ { "output_type": "stream", "stream": "stdout", "text": [ "(410802, 'CCCc1nn(C)c2c1nc(-c1cc(S(=O)(=O)N3CCN(C)CC3)ccc1OCC)[nH]c2=O', 1.0)\n", "(1351311, 'CCCc1nn(C)c2c1nc(-c1cc(S(=O)(=O)N3CCCCC3)ccc1OCC)[nH]c2=O', 0.88135593220339)\n", "(1351310, 'CCCc1nn(C)c2c1nc(-c1cc(S(=O)(=O)N3CCCCCC3)ccc1OCC)[nH]c2=O', 0.88135593220339)\n", "(80636, 'CCCc1nn(C)c2c1nc(-c1cc(S(=O)(=O)N3CCNCC3)ccc1OCC)[nH]c2=O', 0.866666666666667)\n", "(80694, 'CCCc1nn(C)c2c1nc(-c1cc(S(=O)(=O)N3CCN(CCO)CC3)ccc1OCC)[nH]c2=O', 0.838709677419355)\n", "(488008, 'CCCc1nn(C)c2c1nc(-c1cc(S(=O)(=O)N3CCN(c4ccccc4)CC3)ccc1OCC)[nH]c2=O', 0.825396825396825)\n", "(512303, 'CCCc1nn(C)c2c1nc(-c1cc(S(=O)(=O)N3CCC(C(N)=O)CC3)ccc1OCC)[nH]c2=O', 0.8125)\n", "(410662, 'CCCc1nn(C)c2c1nc(-c1cc(S(=O)(=O)N3CCN(CCC(=O)O)CC3)ccc1OCC)[nH]c2=O', 0.8125)\n", "(488151, 'CCCc1nn(C)c2c1nc(-c1cc(S(=O)(=O)N3CCN(C4CCCCC4)CC3)ccc1OCC)[nH]c2=O', 0.8)\n", "(410656, 'CCCc1nn(C)c2c1nc(-c1cc(S(=O)(=O)N3CCC(C(=O)O)CC3)ccc1OCC)[nH]c2=O', 0.8)\n", "(1334756, 'CCOc1ccc(S(=O)(=O)N2CCN(C)CC2)cc1-c1nc2c(C)nn(C)c2c(=O)[nH]1', 0.8)\n", "(488072, 'CCCc1nn(C)c2c1nc(-c1cc(S(=O)(=O)N3CCN(c4ccc(F)cc4)CC3)ccc1OCC)[nH]c2=O', 0.8)\n", "(488073, 'CCCc1nn(C)c2c1nc(-c1cc(S(=O)(=O)N3CCN(c4ccccc4Cl)CC3)ccc1OCC)[nH]c2=O', 0.787878787878788)\n", "(488147, 'CCCc1nn(C)c2c1nc(-c1cc(S(=O)(=O)N3CCN(c4ccc(Cl)cc4)CC3)ccc1OCC)[nH]c2=O', 0.787878787878788)\n", "(1351309, 'CCCc1nn(C)c2c1nc(-c1cc(S(=O)(=O)N(CC)CC)ccc1OCC)[nH]c2=O', 0.783333333333333)\n", "(488146, 'CCCc1nn(C)c2c1nc(-c1cc(S(=O)(=O)N3CCN(c4cccc(Cl)c4)CC3)ccc1OCC)[nH]c2=O', 0.776119402985075)\n", "(488009, 'CCCc1nn(C)c2c1nc(-c1cc(S(=O)(=O)N3CCN(c4ccccc4C)CC3)ccc1OCC)[nH]c2=O', 0.776119402985075)\n", "(488010, 'CCCc1nn(C)c2c1nc(-c1cc(S(=O)(=O)N3CCN(c4ccccc4OC)CC3)ccc1OCC)[nH]c2=O', 0.776119402985075)\n", "(410657, 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'CCCOc1ccc(S(=O)(=O)N2CCC(C(=O)O)CC2)cc1-c1nc2c(CCC)nn(C)c2c(=O)[nH]1', 0.735294117647059)\n", "(1334603, 'CCCc1n[nH]c2c1nc(-c1cc(S(=O)(=O)N3CCN(C)CC3)ccc1OCC)[nH]c2=O', 0.734375)\n", "(410660, 'CCCc1nn(C)c2c1nc(-c1cc(S(=O)(=O)N3CCC(CCCC(=O)O)CC3)ccc1OCC)[nH]c2=O', 0.732394366197183)\n", "(283528, 'CCCc1nc(C)c2c(=O)[nH]c(-c3cc(S(=O)(=O)N4CCN(C)CC4)ccc3OCC)nn12', 0.727272727272727)\n", "(410742, 'CCCOc1ccc(S(=O)(=O)N2CCN(CCP(=O)(O)O)CC2)cc1-c1nc2c(CCC)nn(C)c2c(=O)[nH]1', 0.72463768115942)\n", "(410675, 'CCCOc1ccc(S(=O)(=O)N2CCC(CC(=O)O)CC2)cc1-c1nc2c(CCC)nn(C)c2c(=O)[nH]1', 0.72463768115942)\n", "(488011, 'CCCc1nn(C)c2c1nc(-c1cc(S(=O)(=O)N3CCN(c4cccc(C(F)(F)F)c4)CC3)ccc1OCC)[nH]c2=O', 0.722222222222222)\n", "(410755, 'CCCOc1ccc(S(=O)(=O)N2CCC(CP(=O)(O)O)CC2)cc1-c1nc2c(CCC)nn(C)c2c(=O)[nH]1', 0.714285714285714)\n", "(410731, 'CCCOc1ccc(S(=O)(=O)N2CCN(CCP(=O)(OCC)OCC)CC2)cc1-c1nc2c(CCC)nn(C)c2c(=O)[nH]1', 0.714285714285714)\n", "(410746, 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molregnosmilessimilarity
0 410802 CCCc1nn(C)c2c1nc(-c1cc(S(=O)(=O)N3CCN(C)CC3)ccc1OCC)[nH]c2=O 1.000000
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molregnosmilessimilarity
0 410802 CCCc1nn(C)c2c1nc(-c1cc(S(=O)(=O)N3CCN(C)CC3)ccc1OCC)[nH]c2=O 1.000000
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molregnosmilessimilaritymol
0 410802 CCCc1nn(C)c2c1nc(-c1cc(S(=O)(=O)N3CCN(C)CC3)ccc1OCC)[nH]c2=O 1.000000 \"Mol\"/
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4 80694 CCCc1nn(C)c2c1nc(-c1cc(S(=O)(=O)N3CCN(CCO)CC3)ccc1OCC)[nH]c2=O 0.838710 \"Mol\"/
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molregnosmilessimilaritymollogpmw
0 410802 CCCc1nn(C)c2c1nc(-c1cc(S(=O)(=O)N3CCN(C)CC3)ccc1OCC)[nH]c2=O 1.000000 \"Mol\"/ 1.6109 474.587
1 1351311 CCCc1nn(C)c2c1nc(-c1cc(S(=O)(=O)N3CCCCC3)ccc1OCC)[nH]c2=O 0.881356 \"Mol\"/ 2.8494 459.572
2 1351310 CCCc1nn(C)c2c1nc(-c1cc(S(=O)(=O)N3CCCCCC3)ccc1OCC)[nH]c2=O 0.881356 \"Mol\"/ 3.2395 473.599
3 80636 CCCc1nn(C)c2c1nc(-c1cc(S(=O)(=O)N3CCNCC3)ccc1OCC)[nH]c2=O 0.866667 \"Mol\"/ 1.2687 460.560
4 80694 CCCc1nn(C)c2c1nc(-c1cc(S(=O)(=O)N3CCN(CCO)CC3)ccc1OCC)[nH]c2=O 0.838710 \"Mol\"/ 0.9734 504.613
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molregnosmilessimilaritymollogpmw
193 453288 CCCc1c2nc(-c3cc(S(=O)(=O)N4CCN(CC)CC4)cnc3OCCOC)[nH]c(=O)c2nn1C 0.5 \"Mol\"/ 1.0225 519.628
184 1334770 CCCc1nn(C)c2c1nc(-c1ccc(=O)[nH]n1)[nH]c2=O 0.5 \"Mol\"/ 0.3594 286.295
185 511950 CCCCN1C(=O)C2=C(N=C(c3cc(S(=O)(=O)N4CCN(C)CC4)ccc3OCC)NC2)C1=O 0.5 \"Mol\"/ 0.7942 489.598
186 1353821 CCCc1nn(C)c2c1nc(-c1cccc(Br)c1)[nH]c2=O 0.5 \"Mol\"/ 3.0386 347.216
187 326382 CCOc1ccc(S(=O)(=O)N2CCN(C)CC2)cc1-c1nc2c(nc3cccc(CC)n32)c(O)n1 0.5 \"Mol\"/ 2.5473 496.593
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mwlogp
count 194.000000 194.000000
mean 486.932845 2.290035
std 91.490079 0.970899
min 268.320000 -0.048300
25% 448.825000 1.579575
50% 498.012000 2.293320
75% 537.399000 2.924625
max 866.980000 4.731700
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" ], "metadata": {}, "output_type": "pyout", "prompt_number": 49, "text": [ " mw logp\n", "count 194.000000 194.000000\n", "mean 486.932845 2.290035\n", "std 91.490079 0.970899\n", "min 268.320000 -0.048300\n", "25% 448.825000 1.579575\n", "50% 498.012000 2.293320\n", "75% 537.399000 2.924625\n", "max 866.980000 4.731700" ] } ], "prompt_number": 49 }, { "cell_type": "code", "collapsed": false, "input": [ "rcParams['figure.figsize'] = 12,12" ], "language": "python", "metadata": {}, "outputs": [], "prompt_number": 50 }, { "cell_type": "code", "collapsed": false, "input": [ "data['logp'].hist()" ], "language": "python", "metadata": {}, "outputs": [ { "metadata": {}, "output_type": "pyout", "prompt_number": 51, "text": [ "" ] }, { "metadata": {}, "output_type": "display_data", "png": 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eAADa0+kFSun0rqTjXD1ncu/l0uj0AgBALL1s0Gtam/Nb3agOwG6jOgATPHf2ZukFAKA9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\nRnUAzsjSCwBAe5ZeNhyqAzD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sLMzreST/TZnyJtddN4FFix6ndOnrmDRphQqxiIgPysuhLzvZo8Z3Ansv2q6R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\nBWQA71OnzjFs2bLuR3OLZ82axaBBvyAaPZKEhG9o3Hglc+fOoF69ers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"text": [ "" ] } ], "prompt_number": 52 }, { "cell_type": "code", "collapsed": false, "input": [ "data[data['mw']>800][['molregno','mol','mw','logp']]" ], "language": "python", "metadata": {}, "outputs": [ { "html": [ "
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molregnomolmwlogp
62 487046 \"Mol\"/ 852.997 2.6245
92 487045 \"Mol\"/ 866.980 2.7168
\n", "
" ], "metadata": {}, "output_type": "pyout", "prompt_number": 53, "text": [ " molregno mol mw logp\n", "62 487046 \"Mol\"/ 852.997 2.6245\n", "92 487045 \"Mol\"/ 866.980 2.7168" ] } ], "prompt_number": 53 }, { "cell_type": "heading", "level": 4, "metadata": {}, "source": [ "Substructure search within the table" ] }, { "cell_type": "code", "collapsed": false, "input": [ "qsmi = 'c1nn(C)c2c1nc[nH]c2=O'" ], "language": "python", "metadata": {}, "outputs": [], "prompt_number": 54 }, { "cell_type": "code", "collapsed": false, "input": [ "qmol = Chem.MolFromSmiles(qsmi)" ], "language": "python", "metadata": {}, "outputs": [], "prompt_number": 55 }, { "cell_type": "code", "collapsed": false, "input": [ "qmol" ], "language": "python", "metadata": {}, "outputs": [ { "metadata": {}, "output_type": "pyout", "png": 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molregnosmilessimilaritymollogpmw
0 410802 CCCc1nn(C)c2c1nc(-c1cc(S(=O)(=O)N3CCN(C)CC3)ccc1OCC)[nH]c2=O 1.000000 \"Mol\"/ 1.6109 474.587
1 1351311 CCCc1nn(C)c2c1nc(-c1cc(S(=O)(=O)N3CCCCC3)ccc1OCC)[nH]c2=O 0.881356 \"Mol\"/ 2.8494 459.572
2 1351310 CCCc1nn(C)c2c1nc(-c1cc(S(=O)(=O)N3CCCCCC3)ccc1OCC)[nH]c2=O 0.881356 \"Mol\"/ 3.2395 473.599
3 80636 CCCc1nn(C)c2c1nc(-c1cc(S(=O)(=O)N3CCNCC3)ccc1OCC)[nH]c2=O 0.866667 \"Mol\"/ 1.2687 460.560
4 80694 CCCc1nn(C)c2c1nc(-c1cc(S(=O)(=O)N3CCN(CCO)CC3)ccc1OCC)[nH]c2=O 0.838710 \"Mol\"/ 0.9734 504.613
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" ], "metadata": {}, "output_type": "pyout", "prompt_number": 59, "text": [ " molregno smiles similarity mol logp mw\n", "0 410802 CCCc1nn(C)c2c1nc(-c1cc(S(=O)(=O)N3CCN(C)CC3)ccc1OCC)[nH]c2=O 1.000000 \"Mol\"/ 1.6109 474.587\n", "1 1351311 CCCc1nn(C)c2c1nc(-c1cc(S(=O)(=O)N3CCCCC3)ccc1OCC)[nH]c2=O 0.881356 \"Mol\"/ 2.8494 459.572\n", "2 1351310 CCCc1nn(C)c2c1nc(-c1cc(S(=O)(=O)N3CCCCCC3)ccc1OCC)[nH]c2=O 0.881356 \"Mol\"/ 3.2395 473.599\n", "3 80636 CCCc1nn(C)c2c1nc(-c1cc(S(=O)(=O)N3CCNCC3)ccc1OCC)[nH]c2=O 0.866667 \"Mol\"/ 1.2687 460.560\n", "4 80694 CCCc1nn(C)c2c1nc(-c1cc(S(=O)(=O)N3CCN(CCO)CC3)ccc1OCC)[nH]c2=O 0.838710 \"Mol\"/ 0.9734 504.613" ] } ], "prompt_number": 59 }, { "cell_type": "code", "collapsed": false, "input": [ "data.groupby(data['mol'] >= qmol).describe().unstack()" ], "language": "python", "metadata": {}, "outputs": [ { "html": [ "
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logpmolregnomwsimilarity
countmeanstdmin25%50%75%maxcountmeanstdmin25%50%75%maxcountmeanstdmin25%50%75%maxcountmeanstdmin25%50%75%max
mol
False 104 2.074994 0.778351-0.0483 1.549950 2.10405 2.586725 4.4372 104 795393.692308 546222.400768 28710 304713.75 562140.5 1441476.25 1575540 104 493.938654 45.641263 391.453 462.61600 491.0795 518.88700 624.701 104 0.595978 0.052087 0.5 0.566521 0.600000 0.626866 0.734375
True 90 2.538528 1.107499 0.3034 1.620075 2.65905 3.322050 4.7317 90 709987.411111 449869.213609 80558 410694.50 488009.5 1334760.50 1376119 90 478.837244 124.968717 268.320 386.95875 504.5910 558.42875 866.980 90 0.670030 0.113819 0.5 0.567983 0.691176 0.753623 1.000000
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" ], "metadata": {}, "output_type": "pyout", "prompt_number": 60, "text": [ " logp molregno mw similarity \n", " count mean std min 25% 50% 75% max count mean std min 25% 50% 75% max count mean std min 25% 50% 75% max count mean std min 25% 50% 75% max\n", "mol \n", "False 104 2.074994 0.778351 -0.0483 1.549950 2.10405 2.586725 4.4372 104 795393.692308 546222.400768 28710 304713.75 562140.5 1441476.25 1575540 104 493.938654 45.641263 391.453 462.61600 491.0795 518.88700 624.701 104 0.595978 0.052087 0.5 0.566521 0.600000 0.626866 0.734375\n", "True 90 2.538528 1.107499 0.3034 1.620075 2.65905 3.322050 4.7317 90 709987.411111 449869.213609 80558 410694.50 488009.5 1334760.50 1376119 90 478.837244 124.968717 268.320 386.95875 504.5910 558.42875 866.980 90 0.670030 0.113819 0.5 0.567983 0.691176 0.753623 1.000000" ] } ], "prompt_number": 60 }, { "cell_type": "code", "collapsed": false, "input": [ "data['containsQ'] = data['mol'] >= qmol" ], "language": "python", "metadata": {}, "outputs": [], "prompt_number": 61 }, { "cell_type": "code", "collapsed": false, "input": [ "data.head(2)" ], "language": "python", "metadata": {}, "outputs": [ { "html": [ "
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molregnosmilessimilaritymollogpmwcontainsQ
0 410802 CCCc1nn(C)c2c1nc(-c1cc(S(=O)(=O)N3CCN(C)CC3)ccc1OCC)[nH]c2=O 1.000000 \"Mol\"/ 1.6109 474.587 True
1 1351311 CCCc1nn(C)c2c1nc(-c1cc(S(=O)(=O)N3CCCCC3)ccc1OCC)[nH]c2=O 0.881356 \"Mol\"/ 2.8494 459.572 True
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" ], "metadata": {}, "output_type": "pyout", "prompt_number": 62, "text": [ " molregno smiles similarity mol logp mw containsQ\n", "0 410802 CCCc1nn(C)c2c1nc(-c1cc(S(=O)(=O)N3CCN(C)CC3)ccc1OCC)[nH]c2=O 1.000000 \"Mol\"/ 1.6109 474.587 True\n", "1 1351311 CCCc1nn(C)c2c1nc(-c1cc(S(=O)(=O)N3CCCCC3)ccc1OCC)[nH]c2=O 0.881356 \"Mol\"/ 2.8494 459.572 True" ] } ], "prompt_number": 62 }, { "cell_type": "code", "collapsed": false, "input": [ "data.boxplot('similarity',by='containsQ')" ], "language": "python", "metadata": {}, "outputs": [ { "metadata": {}, "output_type": "pyout", "prompt_number": 63, "text": [ "" ] }, { "metadata": {}, "output_type": "display_data", "png": 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"text": [ "" ] } ], "prompt_number": 63 }, { "cell_type": "code", "collapsed": false, "input": [ "conn.close()" ], "language": "python", "metadata": {}, "outputs": [], "prompt_number": 64 }, { "cell_type": "heading", "level": 4, "metadata": {}, "source": [ "More useful RDKit stuff here: \n", "http://www.rdkit.org/UGM/2012/ and \n", "https://github.com/rdkit/UGM_2013" ] } ], "metadata": {} } ] }