# Gene-gRNA group pairs

`gene_gRNA_group_pairs.Rd`

The pairs of genes and gRNA groups that we seek to test for association. Columns `gene_id` (required), `gRNA_group` (required), and `pair_type` (optional).

    data(gene_gRNA_group_pairs)

## Format

An object of class `tbl_df` (inherits from `tbl`, `data.frame`) with 120 rows and 3 columns.

## Overview

This object is part of the example data. The data are taken from the paper "A genome-wide framework for mapping gene regulation via cellular genetic screens" by Gasperini et al., 2019. The authors used a CRISPRi-based assay to target 5,000+ putative enhancers in a population of K562 cells. The authors additionally targeted 200+ gene transcription start sites (TSSs) and designed a library of 50 non-targeting gRNAs to serve as negative controls. Genes, gRNAs, and cells are all down-sampled to reduce the size of the data.