Core function

run_sceptre_high_moi()

Run SCEPTRE on high multiplicity-of-infection single-cell CRISPR screen data

Auxiliary functions

threshold_gRNA_matrix()

Threshold gRNA count matrix

combine_perturbations()

Combine perturbations

make_qq_plot()

Make QQ-plot

plot_result()

Plot result

Data

gene_matrix

Gene expression matrix

gRNA_matrix

gRNA expression matrix

covariate_matrix

Covariate matrix

gRNA_groups_table

gRNA groups table

gene_gRNA_group_pairs

Gene-gRNA group pairs