{
  "document": {
    "acknowledgments": [
      {
        "names": [
          "Nathaniel Adams",
          "Laura Gaydosh-Combs",
          "Kevin Dyer",
        ],
        "summary": "discovered this vulnerability"
      }
    ],
    "category": "csaf_security_advisory",
    "csaf_version": "2.0",
    "distribution": {
      "text": "Disclosure is not limited",
      "tlp": {
        "label": "WHITE",
        "url": "https://www.cisa.gov/news-events/news/traffic-light-protocol-tlp-definitions-and-usage"
      }
    },
    "lang": "en-US",
    "notes": [
      {
        "category": "legal_disclaimer",
        "text": "This product is provided subject to this Notification (https://www.cisa.gov/notification) and this Privacy & Use policy (https://www.cisa.gov/privacy-policy).",
        "title": "Legal Notice and Terms of Use"
      },
      {
        "category": "summary",
        "text": "Successful exploitation of this vulnerability could allow an attacker to modify .fsa/.hid output files, tampering with DNA data and resulting in inaccurate test results.",
        "title": "Advisory Summary"
      },
      {
        "category": "other",
        "text": "Healthcare and Public Health",
        "title": "Critical infrastructure sectors"
      },
      {
        "category": "other",
        "text": "Worldwide",
        "title": "Countries/areas deployed"
      },
      {
        "category": "other",
        "text": "United States",
        "title": "Company headquarters location"
      },
      {
        "category": "general",
        "text": "CISA recommends users take defensive measures to minimize the risk of exploitation of this vulnerability.",
        "title": "Recommended Practices"
      },
      {
        "category": "general",
        "text": "Minimize network exposure for all control system devices and/or systems, ensuring they are not accessible from the internet.",
        "title": "Recommended Practices"
      },
      {
        "category": "general",
        "text": "When remote access is required, use more secure methods, such as Virtual Private Networks (VPNs), recognizing VPNs may have vulnerabilities and should be updated to the most current version available. Also recognize VPN is only as secure as the connected devices.",
        "title": "Recommended Practices"
      },
      {
        "category": "general",
        "text": "CISA reminds organizations to perform proper impact analysis and risk assessment prior to deploying defensive measures.",
        "title": "Recommended Practices"
      },
      {
        "category": "general",
        "text": "CISA also provides a section for control systems security recommended practices on the ICS webpage on cisa.gov/ics. Several CISA products detailing cyber defense best practices are available for reading and download, including Improving Industrial Control Systems Cybersecurity with Defense-in-Depth Strategies.",
        "title": "Recommended Practices"
      },
      {
        "category": "general",
        "text": "CISA encourages organizations to implement recommended cybersecurity strategies for proactive defense of ICS assets.",
        "title": "Recommended Practices"
      },
      {
        "category": "general",
        "text": "Additional mitigation guidance and recommended practices are publicly available on the ICS webpage at cisa.gov/ics in the technical information paper, ICS-TIP-12-146-01B--Targeted Cyber Intrusion Detection and Mitigation Strategies.",
        "title": "Recommended Practices"
      },
      {
        "category": "general",
        "text": "Organizations observing suspected malicious activity should follow established internal procedures and report findings to CISA for tracking and correlation against other incidents.",
        "title": "Recommended Practices"
      },
      {
        "category": "general",
        "text": "No known public exploitation specifically targeting this vulnerability has been reported to CISA at this time. This vulnerability is not exploitable remotely.",
        "title": "Recommended Practices"
      }
    ],
    "publisher": {
      "category": "coordinator",
      "contact_details": "central@cisa.dhs.gov",
      "name": "CISA",
      "namespace": "https://www.cisa.gov/"
    },
    "references": [
      {
        "category": "self",
        "summary": "ICS Advisory ICSMA-26-216-01 JSON",
        "url": "https://raw.githubusercontent.com/cisagov/CSAF/develop/csaf_files/OT/white/2026/icsma-26-216-01.json"
      },
      {
        "category": "self",
        "summary": "ICSA Advisory ICSMA-26-216-01 - Web Version",
        "url": "https://www.cisa.gov/news-events/ics-medical-advisories/icsma-26-216-01"
      },
      {
        "category": "external",
        "summary": "Recommended Practices",
        "url": "https://www.cisa.gov/uscert/ics/alerts/ICS-ALERT-10-301-01"
      },
      {
        "category": "external",
        "summary": "Recommended Practices",
        "url": "https://www.cisa.gov/resources-tools/resources/ics-recommended-practices"
      },
      {
        "category": "external",
        "summary": "Recommended Practices",
        "url": "https://www.cisa.gov/sites/default/files/publications/Cybersecurity_Best_Practices_for_Industrial_Control_Systems.pdf"
      },
      {
        "category": "external",
        "summary": "Recommended Practices",
        "url": "https://www.cisa.gov/topics/industrial-control-systems"
      },
      {
        "category": "external",
        "summary": "Recommended Practices",
        "url": "https://www.cisa.gov/news-events/ics-alerts/ics-alert-10-301-01"
      },
      {
        "category": "external",
        "summary": "Recommended Practices",
        "url": "https://www.cisa.gov/sites/default/files/recommended_practices/NCCIC_ICS-CERT_Defense_in_Depth_2016_S508C.pdf"
      },
      {
        "category": "external",
        "summary": "Recommended Practices",
        "url": "https://www.cisa.gov/news-events/news/targeted-cyber-intrusion-detection-and-mitigation-strategies-update-b"
      },
      {
        "category": "external",
        "summary": "Recommended Practices",
        "url": "https://www.cisa.gov/secure-our-world/teach-employees-avoid-phishing"
      },
      {
        "category": "external",
        "summary": "Recommended Practices",
        "url": "https://www.cisa.gov/news-events/news/avoiding-social-engineering-and-phishing-attacks"
      }
    ],
    "title": "Thermo Fisher Applied Biosystems Genetic Analyzers",
    "tracking": {
      "current_release_date": "2026-08-04T06:00:00.000000Z",
      "generator": {
        "date": "2026-08-03T22:07:31.548527Z",
        "engine": {
          "name": "CISA CSAF Generator",
          "version": "1.0.0"
        }
      },
      "id": "ICSMA-26-216-01",
      "initial_release_date": "2026-08-04T06:00:00.000000Z",
      "revision_history": [
        {
          "date": "2026-08-04T06:00:00.000000Z",
          "legacy_version": "Initial",
          "number": "1",
          "summary": "Initial Publication"
        }
      ],
      "status": "final",
      "version": "1"
    }
  },
  "product_tree": {
    "branches": [
      {
        "branches": [
          {
            "branches": [
              {
                "category": "product_version_range",
                "name": "<=4.0.2",
                "product": {
                  "name": "Thermo Fisher Applied Biosystems 3500/3500xL Series Data Collection Software: <=4.0.2",
                  "product_id": "CSAFPID-0001"
                }
              }
            ],
            "category": "product_name",
            "name": "Applied Biosystems 3500/3500xL Series Data Collection Software"
          },
          {
            "branches": [
              {
                "category": "product_version_range",
                "name": "<=5.0.2",
                "product": {
                  "name": "Thermo Fisher Applied Biosystems 3730/3730xL Series Data Collection Software: <=5.0.2",
                  "product_id": "CSAFPID-0002"
                }
              }
            ],
            "category": "product_name",
            "name": "Applied Biosystems 3730/3730xL Series Data Collection Software"
          },
          {
            "branches": [
              {
                "category": "product_version_range",
                "name": "<=1.2.5",
                "product": {
                  "name": "Thermo Fisher Applied Biosystems SeqStudio Genetic Analyzer Data Collection Software: <=1.2.5",
                  "product_id": "CSAFPID-0003"
                }
              }
            ],
            "category": "product_name",
            "name": "Applied Biosystems SeqStudio Genetic Analyzer Data Collection Software"
          },
          {
            "branches": [
              {
                "category": "product_version_range",
                "name": "<=1.2.0",
                "product": {
                  "name": "Thermo Fisher Applied Biosystems SeqStudio Flex Series Instrument Software: <=1.2.0",
                  "product_id": "CSAFPID-0004"
                }
              }
            ],
            "category": "product_name",
            "name": "Applied Biosystems SeqStudio Flex Series Instrument Software"
          },
          {
            "branches": [
              {
                "category": "product_version_range",
                "name": "<=v1.7.3",
                "product": {
                  "name": "Thermo Fisher Applied Biosystems GeneMapper ID-X Software: <=v1.7.3",
                  "product_id": "CSAFPID-0005"
                }
              }
            ],
            "category": "product_name",
            "name": "Applied Biosystems GeneMapper ID-X Software"
          },
          {
            "branches": [
              {
                "category": "product_version_range",
                "name": "<=4.1",
                "product": {
                  "name": "Thermo Fisher Applied Biosystems 3130 Series Data Collection Software: <=4.1",
                  "product_id": "CSAFPID-0006"
                }
              }
            ],
            "category": "product_name",
            "name": "Applied Biosystems 3130 Series Data Collection Software"
          },
          {
            "branches": [
              {
                "category": "product_version_range",
                "name": "<=2.0",
                "product": {
                  "name": "Thermo Fisher ABI PRISM 3100/3100-Avant Data Collection Software: <=2.0",
                  "product_id": "CSAFPID-0007"
                }
              }
            ],
            "category": "product_name",
            "name": "ABI PRISM 3100/3100-Avant Data Collection Software"
          },
          {
            "branches": [
              {
                "category": "product_version_range",
                "name": "<=3.1",
                "product": {
                  "name": "Thermo Fisher ABI PRISM 310 Data Collection Software: <=3.1",
                  "product_id": "CSAFPID-0008"
                }
              }
            ],
            "category": "product_name",
            "name": "ABI PRISM 310 Data Collection Software"
          }
        ],
        "category": "vendor",
        "name": "Thermo Fisher"
      }
    ]
  },
  "vulnerabilities": [
    {
      "cve": "CVE-2026-17583",
      "cwe": {
        "id": "CWE-353",
        "name": "Missing Support for Integrity Check"
      },
      "notes": [
        {
          "category": "summary",
          "text": "The affected product is vulnerable because its .fsa/.hid output files can be edited. An attacker could tamper with these files, altering DNA data and resulting in inaccurate DNA test outcomes.",
          "title": "Vulnerability Summary"
        },
        {
          "category": "details",
          "text": "SSVCv2/E:N/A:N/2026-08-03T06:00:00.000000Z",
          "title": "SSVC"
        }
      ],
      "product_status": {
        "known_affected": [
          "CSAFPID-0001",
          "CSAFPID-0002",
          "CSAFPID-0003",
          "CSAFPID-0004",
          "CSAFPID-0005",
          "CSAFPID-0006",
          "CSAFPID-0007",
          "CSAFPID-0008"
        ]
      },
      "references": [
        {
          "category": "external",
          "summary": "cwe.mitre.org",
          "url": "https://cwe.mitre.org/data/definitions/353.html"
        },
        {
          "category": "external",
          "summary": "www.cve.org",
          "url": "https://www.cve.org/CVERecord?id=CVE-2026-17583"
        },
        {
          "category": "external",
          "summary": "www.first.org",
          "url": "https://www.first.org/cvss/calculator/3.1#CVSS:3.1/AV:L/AC:L/PR:N/UI:N/S:U/C:H/I:H/A:H"
        },
        {
          "category": "external",
          "summary": "www.first.org",
          "url": "https://www.first.org/cvss/calculator/4.0#CVSS:4.0/AV:L/AC:L/AT:N/PR:N/UI:N/VC:N/VI:H/VA:N/SC:N/SI:H/SA:N"
        }
      ],
      "remediations": [
        {
          "category": "mitigation",
          "details": "Thermo Fisher has developed security updates to address the vulnerability. The security updates implement the use of digital signatures on the instrument software that adds an extralayer of protection. Moving forward, this will help users verify that data files have not been modified.",
          "product_ids": [
            "CSAFPID-0001",
            "CSAFPID-0002",
            "CSAFPID-0003",
            "CSAFPID-0004",
            "CSAFPID-0005",
            "CSAFPID-0006",
            "CSAFPID-0007",
            "CSAFPID-0008"
          ]
        },
        {
          "category": "vendor_fix",
          "details": "Applied Biosystems 3500/3500xL Series Data Collection Software: Update to version 4.0.3",
          "product_ids": [
            "CSAFPID-0001"
          ],
          "url": "https://downloads.thermofisher.com/3500_DCS_v4.0.3_Patch/v4.0.3_Patch_Installer.exe"
        },
        {
          "category": "vendor_fix",
          "details": "Applied Biosystems 3730/3730xL Series Data Collection Software: Update to version 5.0.3",
          "product_ids": [
            "CSAFPID-0002"
          ],
          "url": "https://downloads.thermofisher.com/3730xl_UDC_v5.0.3_Patch/3730xl_UDC_v5.0.3_Patch.exe"
        },
        {
          "category": "vendor_fix",
          "details": "Applied Biosystems SeqStudio Genetic Analyzer Data Collection Software: Update to version 1.2.6",
          "product_ids": [
            "CSAFPID-0003"
          ],
          "url": "https://downloads.thermofisher.com/SeqStudio/1.2.6/SeqStudio-1.2.6.abpkg"
        },
        {
          "category": "vendor_fix",
          "details": "Applied Biosystems SeqStudio Flex Series Instrument Software: Update to version 1.2.1",
          "product_ids": [
            "CSAFPID-0004"
          ],
          "url": "https://downloads.thermofisher.com/SeqStudioFlex/1.2.1/SeqStudioFlex-1.2.1.abpkg"
        },
        {
          "category": "vendor_fix",
          "details": "Applied Biosystems GeneMapper ID-X Software: Update to version 1.7.4",
          "product_ids": [
            "CSAFPID-0005"
          ],
          "url": "https://downloads.thermofisher.com/GeneMapperID-Xv1.7.4_Patch/GMIDX_v1.7.4_Patch.exe"
        },
        {
          "category": "vendor_fix",
          "details": "Applied Biosystems 3130 Series Data Collection Software: Product is End of Life (EoL), no update provided",
          "product_ids": [
            "CSAFPID-0006"
          ]
        },
        {
          "category": "vendor_fix",
          "details": "ABI PRISM 3100/3100-Avant Data Collection Software: Product is End of Life (EoL), no update provided",
          "product_ids": [
            "CSAFPID-0007"
          ]
        },
        {
          "category": "vendor_fix",
          "details": "ABI PRISM 310 Data Collection Software: Product is End of Life (EoL), no update provided",
          "product_ids": [
            "CSAFPID-0008"
          ]
        },
        {
          "category": "mitigation",
          "details": "For users who are unable to immediately implement all applicable security updates, Thermo Fisher Scientific recommends implementing the following interim mitigation measures until the applicable updates have been installed: Maintain a secure chain of custody for files generated by the HID instrumentation throughout the analysis workflow.",
          "product_ids": [
            "CSAFPID-0001",
            "CSAFPID-0002",
            "CSAFPID-0003",
            "CSAFPID-0004",
            "CSAFPID-0005",
            "CSAFPID-0006",
            "CSAFPID-0007",
            "CSAFPID-0008"
          ]
        },
        {
          "category": "mitigation",
          "details": "Store generated files on encrypted, password-protected storage media (for example, encrypted USB drives or encrypted hard drives).",
          "product_ids": [
            "CSAFPID-0001",
            "CSAFPID-0002",
            "CSAFPID-0003",
            "CSAFPID-0004",
            "CSAFPID-0005",
            "CSAFPID-0006",
            "CSAFPID-0007",
            "CSAFPID-0008"
          ]
        },
        {
          "category": "mitigation",
          "details": "Restrict access to generated files to authorized personnel in accordance with your laboratory's access control policies.",
          "product_ids": [
            "CSAFPID-0001",
            "CSAFPID-0002",
            "CSAFPID-0003",
            "CSAFPID-0004",
            "CSAFPID-0005",
            "CSAFPID-0006",
            "CSAFPID-0007",
            "CSAFPID-0008"
          ]
        },
        {
          "category": "mitigation",
          "details": "Apply the principle of least privilege by limiting user permissions on systems operating the HID instrumentation or hosting associated data analysis and secondary analysis software.",
          "product_ids": [
            "CSAFPID-0001",
            "CSAFPID-0002",
            "CSAFPID-0003",
            "CSAFPID-0004",
            "CSAFPID-0005",
            "CSAFPID-0006",
            "CSAFPID-0007",
            "CSAFPID-0008"
          ]
        },
        {
          "category": "mitigation",
          "details": "Leverage firewall rules and network access control lists (NACLs) to restrict internet connectivity to only trusted sources.",
          "product_ids": [
            "CSAFPID-0001",
            "CSAFPID-0002",
            "CSAFPID-0003",
            "CSAFPID-0004",
            "CSAFPID-0005",
            "CSAFPID-0006",
            "CSAFPID-0007",
            "CSAFPID-0008"
          ]
        },
        {
          "category": "mitigation",
          "details": "For more information, refer to Thermo Fisher's security bulletin.",
          "product_ids": [
            "CSAFPID-0001",
            "CSAFPID-0002",
            "CSAFPID-0003",
            "CSAFPID-0004",
            "CSAFPID-0005",
            "CSAFPID-0006",
            "CSAFPID-0007",
            "CSAFPID-0008"
          ],
          "url": "https://documents.thermofisher.com/TFS-Assets/CORP/Product-Guides/fsa_hid_bulletin.pdf"
        }
      ],
      "scores": [
        {
          "cvss_v3": {
            "baseScore": 8.4,
            "baseSeverity": "HIGH",
            "vectorString": "CVSS:3.1/AV:L/AC:L/PR:N/UI:N/S:U/C:H/I:H/A:H",
            "version": "3.1"
          },
          "products": [
            "CSAFPID-0001",
            "CSAFPID-0002",
            "CSAFPID-0003",
            "CSAFPID-0004",
            "CSAFPID-0005",
            "CSAFPID-0006",
            "CSAFPID-0007",
            "CSAFPID-0008"
          ]
        }
      ]
    }
  ]
}