CMPD_CHEMBLID,CANONICAL_SMILES,STANDARD_TYPE,RELATION,STANDARD_VALUE,STANDARD_UNITS,pIC50,PROTEIN_ACCESSION,PREF_NAME,DOC_CHEMBLID,ASSAY_SRC_DESCRIPTION,DESCRIPTION,PUBMED_ID,JOURNAL,YEAR,VOLUME,ISSUE,FIRST_PAGE,MOLWEIGHT,ALOGP,PSA,NUM_RO5_VIOLATIONS,Activity
CHEMBL179256,OC(=O)c1ccc2c(c1)nc(c3ccc(O)cc3F)n2C4CCCCC4,IC50,=,1.4,nM,8.853871964,Q8JXU8,Hepatitis C virus NS5B RNA-dependent RNA polymerase,CHEMBL1142688,Scientific Literature,Inhibitory concentration against RNA dependent RNA polymerase nonstructural protein 5B of hepatitis C virus,15743173,J. Med. Chem.,2005,48,5,1314,354.37,4.93,75.35,0,Active
CHEMBL204350,CC(C)(C)CCN1[C@H](C(=C(C1=O)C2=NS(=O)(=O)c3ccccc3N2)O)C(C)(C)C,IC50,=,1.7,nM,8.769551079,Q8JXU8,Hepatitis C virus NS5B RNA-dependent RNA polymerase,CHEMBL1146957,Scientific Literature,Inhibition of HCV NS5B RNA dependent RNA polymerase,16455253,Bioorg. Med. Chem. Lett.,2006,16,8,2205,419.54,2.37,107.45,0,Active
CHEMBL179257,OC(=O)c1ccc2c(c1)nc(c3ccc(O)cc3)n2C4CCCCC4,IC50,=,3,nM,8.522878745,Q8JXU8,Hepatitis C virus NS5B RNA-dependent RNA polymerase,CHEMBL1142688,Scientific Literature,Inhibitory concentration against RNA dependent RNA polymerase nonstructural protein 5B of hepatitis C virus,15743173,J. Med. Chem.,2005,48,5,1314,336.38,4.72,75.35,0,Active
CHEMBL178784,OC(=O)c1ccc2c(C3CCCCC3)c([nH]c2c1)c4ccc(O)cc4,IC50,=,4.8,nM,8.318758763,Q8JXU8,Hepatitis C virus NS5B RNA-dependent RNA polymerase,CHEMBL1142688,Scientific Literature,Inhibitory concentration against RNA dependent RNA polymerase nonstructural protein 5B of hepatitis C virus,15743173,J. Med. Chem.,2005,48,5,1314,335.4,5.51,73.32,1,Active
CHEMBL369319,CN(C)C(=O)Cn1c(c2ccc(OCc3ccccc3)cc2)c(C4CCCCC4)c5ccc(cc15)C(=O)O,IC50,=,6,nM,8.22184875,Q8JXU8,Hepatitis C virus NS5B RNA-dependent RNA polymerase,CHEMBL1142688,Scientific Literature,Inhibitory activity against RNA dependent RNA polymerase nonstructural protein 5B in hepatitis C virus; n=1,15743173,J. Med. Chem.,2005,48,5,1314,510.62,6.79,71.77,2,Active
CHEMBL3651437,CNC(=O)c1c(oc2ccc(c(F)c12)c3cc(cc(F)c3C)C(=O)NC4(COC4)c5ncccn5)c6ccc(F)cc6,IC50,=,6,nM,8.22184875,Q8JXU8,Hepatitis C virus NS5B RNA-dependent RNA polymerase,CHEMBL3639184,BindingDB Database,BindingDB_Patents: Enzyme Assay. HCV NS5B enzyme assay.,NA,,2013,NA,NA,NA,572.53,4.46,106.35,1,Active
CHEMBL191196,CS(=O)(=O)N1CCN(CC1)C(=O)Cn2c(c3ccc(Cl)cc3)c(C4CCCCC4)c5ccc(cc25)C(=O)O,IC50,=,7,nM,8.15490196,Q8JXU8,Hepatitis C virus NS5B RNA-dependent RNA polymerase,CHEMBL1140313,Scientific Literature,Inhibitory activity against by hepatitis C virus NS5B polymerase,15999993,J. Med. Chem.,2005,48,14,4547,558.09,4.9,108.3,1,Active
CHEMBL173466,OC(=O)[C@H](Cc1c[nH]c2ccc(NC(=O)C(=O)O)cc12)NC(=O)c3ccc4c(c3)nc(c5cocc5)n4C6CCCCC6,IC50,=,8,nM,8.096910013,Q8JXU8,Hepatitis C virus NS5B RNA-dependent RNA polymerase,CHEMBL1149207,Scientific Literature,Concentration required for inhibiting hepatitis C virus NS5B RNA polymerase activity.,15013003,Bioorg. Med. Chem. Lett.,2004,14,4,967,583.59,4.36,179.54,1,Active
CHEMBL363199,OC(=O)c1ccc2c(C3CCCCC3)c(c4ccc(Cl)cc4)n(CC(=O)NCC5CC5)c2c1,IC50,=,8,nM,8.096910013,Q8JXU8,Hepatitis C virus NS5B RNA-dependent RNA polymerase,CHEMBL1140313,Scientific Literature,Inhibitory activity against by hepatitis C virus NS5B polymerase,15999993,J. Med. Chem.,2005,48,14,4547,464.98,6.5,71.33,1,Active
CHEMBL210693,CNS(=O)(=O)Nc1ccc2N=C(NS(=O)(=O)c2c1)C3=C(O)c4ccccc4N(NC5CCC5)C3=O,IC50,=,8.7,nM,8.060480747,Q8JXU8,Hepatitis C virus NS5B RNA-dependent RNA polymerase,CHEMBL1138070,Scientific Literature,Inhibition of HCV 1a NS5B RNA polymerase,16650764,Bioorg. Med. Chem. Lett.,2006,16,13,3367,518.57,0,186.05,1,Active
CHEMBL190428,COc1ccc(cc1)c2c(C3CCCCC3)c4ccc(cc4n2CC(=O)N5CCC(CC5)N(C)C)C(=O)O,IC50,=,9,nM,8.045757491,Q8JXU8,Hepatitis C virus NS5B RNA-dependent RNA polymerase,CHEMBL1140313,Scientific Literature,Inhibitory activity against hepatitis C virus NS5B polymerase enzyme; Range=6-9 nM,15999993,J. Med. Chem.,2005,48,14,4547,517.66,2.29,75.01,1,Active
CHEMBL362957,OC(=O)c1ccc2c(C3CCCCC3)c(c4cocc4)n(CC(=O)N5CCC(CC5)N6CCC6)c2c1,IC50,=,9,nM,8.045757491,Q8JXU8,Hepatitis C virus NS5B RNA-dependent RNA polymerase,CHEMBL1140313,Scientific Literature,Inhibitory activity against hepatitis C virus NS5B polymerase enzyme; Range=6-9 nM,15999993,J. Med. Chem.,2005,48,14,4547,489.61,1.29,78.92,0,Active
CHEMBL190098,CCN(CC)C1CCN(CC1)C(=O)Cn2c(c3ccc(OC)cc3)c(C4CCCCC4)c5ccc(cc25)C(=O)O,IC50,=,9,nM,8.045757491,Q8JXU8,Hepatitis C virus NS5B RNA-dependent RNA polymerase,CHEMBL1140313,Scientific Literature,Inhibitory activity against hepatitis C virus NS5B polymerase enzyme; Range=6-9 nM,15999993,J. Med. Chem.,2005,48,14,4547,545.71,2.98,75.01,1,Active
CHEMBL365951,CCN(CC)CC1CN(CCO1)C(=O)Cn2c(c3ccc(OC)cc3)c(C4CCCCC4)c5ccc(cc25)C(=O)O,IC50,=,9,nM,8.045757491,Q8JXU8,Hepatitis C virus NS5B RNA-dependent RNA polymerase,CHEMBL1140313,Scientific Literature,Inhibitory activity against hepatitis C virus NS5B polymerase enzyme; Range=6-9 nM,15999993,J. Med. Chem.,2005,48,14,4547,561.71,2.73,84.24,1,Active
CHEMBL1203926,Cl.Cl.OC(=O)c1ccc2c(C3CCCCC3)c4c5ccccc5N(CCN6CCCCC6)CCn4c2c1,IC50,=,9,nM,8.045757491,Q8JXU8,Hepatitis C virus NS5B RNA-dependent RNA polymerase,CHEMBL1137351,Scientific Literature,Inhibition of HCV NS5B RNA polymerase,17125247,J. Med. Chem.,2006,49,24,6950,471.63,3.96,48.71,0,Active
CHEMBL362909,CCN(CC)C1CCN(CC1)C(=O)Cn2c(c3ccc(Cl)cc3)c(C4CCCCC4)c5ccc(cc25)C(=O)O,IC50,=,9,nM,8.045757491,Q8JXU8,Hepatitis C virus NS5B RNA-dependent RNA polymerase,CHEMBL1140313,Scientific Literature,Inhibitory activity against hepatitis C virus NS5B polymerase enzyme; Range=6-9 nM,15999993,J. Med. Chem.,2005,48,14,4547,550.13,3.66,65.78,1,Active
CHEMBL210671,CC(C)CCN1C(=O)C(=C(O)c2cccnc12)C3=NS(=O)(=O)c4cc(NS(=O)(=O)NCCN)ccc4N3,IC50,=,10,nM,8,Q8JXU8,Hepatitis C virus NS5B RNA-dependent RNA polymerase,CHEMBL1138070,Scientific Literature,Inhibition of HCV 1a NS5B RNA polymerase,16650764,Bioorg. Med. Chem. Lett.,2006,16,13,3367,549.62,-0.32,212.94,1,Active
CHEMBL3651435,CNC(=O)c1c(oc2ccc(c(F)c12)c3cc(ccc3C)C(=O)NC4(COC4)c5ncccn5)c6ccc(F)cc6,IC50,=,10,nM,8,Q8JXU8,Hepatitis C virus NS5B RNA-dependent RNA polymerase,CHEMBL3639184,BindingDB Database,BindingDB_Patents: Enzyme Assay. HCV NS5B enzyme assay.,NA,,2013,NA,NA,NA,554.54,4.25,106.35,1,Active
CHEMBL394002,COc1ccc(CNS(=O)(=O)Nc2ccc3NC(=NS(=O)(=O)c3c2)C4=C(O)c5cccnc5N(CCC(C)C)C4=O)cc1,IC50,=,10,nM,8,Q8JXU8,Hepatitis C virus NS5B RNA-dependent RNA polymerase,CHEMBL1138070,Scientific Literature,Inhibition of HCV 1a NS5B RNA polymerase,16650764,Bioorg. Med. Chem. Lett.,2006,16,13,3367,626.7,2.08,196.14,1,Active
CHEMBL179228,Cc1ccc(cc1)c2c(C3CCCCC3)c4ccc(cc4n2CC(=O)N5CCOCC5)C(=O)O,IC50,=,11,nM,7.958607315,Q8JXU8,Hepatitis C virus NS5B RNA-dependent RNA polymerase,CHEMBL1142688,Scientific Literature,Inhibitory activity against RNA dependent RNA polymerase nonstructural protein 5B in hepatitis C virus; n=1,15743173,J. Med. Chem.,2005,48,5,1314,460.56,5.4,71.77,1,Active
CHEMBL363566,OC(=O)c1ccc2c(C3CCCCC3)c(c4ccc(Cl)cc4)n(CC(=O)N5CCS(=O)(=O)CC5)c2c1,IC50,=,11,nM,7.958607315,Q8JXU8,Hepatitis C virus NS5B RNA-dependent RNA polymerase,CHEMBL1140313,Scientific Literature,Inhibitory activity against by hepatitis C virus NS5B polymerase,15999993,J. Med. Chem.,2005,48,14,4547,529.05,5.31,105.06,2,Active
CHEMBL190945,CC(C)N(C)C(=O)Cn1c(c2ccc(Cl)cc2)c(C3CCCCC3)c4ccc(cc14)C(=O)O,IC50,=,11,nM,7.958607315,Q8JXU8,Hepatitis C virus NS5B RNA-dependent RNA polymerase,CHEMBL1140313,Scientific Literature,Inhibitory activity against by hepatitis C virus NS5B polymerase,15999993,J. Med. Chem.,2005,48,14,4547,467,6.62,62.54,1,Active
CHEMBL378026,CN(C)C(=O)c1ccc(c(COc2ccc(c(F)c2)c3nc4cc(ccc4n3C5CCCCC5)C(=O)O)c1)c6ccc(Cl)cc6,IC50,=,12,nM,7.920818754,Q8JXU8,Hepatitis C virus NS5B RNA-dependent RNA polymerase,CHEMBL1138950,Scientific Literature,Inhibition of HCV 1b BK six His-tagged C-terminal truncated 544 amino acid NS5B RNA dependent RNA polymerase,16854079,J. Med. Chem.,2006,49,15,4721,626.12,8.33,84.66,2,Active
CHEMBL190146,CN1CCN(CC1)C(=O)Cn2c(c3ccc(Cl)cc3)c(C4CCCCC4)c5ccc(cc25)C(=O)O,IC50,=,12,nM,7.920818754,Q8JXU8,Hepatitis C virus NS5B RNA-dependent RNA polymerase,CHEMBL1140313,Scientific Literature,Inhibitory activity against by hepatitis C virus NS5B polymerase,15999993,J. Med. Chem.,2005,48,14,4547,494.02,2.81,65.78,0,Active
CHEMBL372433,CN(CC1CCCN(C)C1)C(=O)Cn2c(c3ccc(Cl)cc3)c(C4CCCCC4)c5ccc(cc25)C(=O)O,IC50,=,12,nM,7.920818754,Q8JXU8,Hepatitis C virus NS5B RNA-dependent RNA polymerase,CHEMBL1140313,Scientific Literature,Inhibitory activity against by hepatitis C virus NS5B polymerase,15999993,J. Med. Chem.,2005,48,14,4547,536.1,3.55,65.78,1,Active
CHEMBL378053,CNC(=O)c1ccc(c(COc2ccc(c(F)c2)c3nc4cc(ccc4n3C5CCCCC5)C(=O)O)c1)c6ccc(Cl)cc6,IC50,=,12,nM,7.920818754,Q8JXU8,Hepatitis C virus NS5B RNA-dependent RNA polymerase,CHEMBL1138950,Scientific Literature,Inhibition of HCV 1b BK six His-tagged C-terminal truncated 544 amino acid NS5B RNA dependent RNA polymerase,16854079,J. Med. Chem.,2006,49,15,4721,612.09,8.13,93.45,2,Active
CHEMBL443044,CN(C)C1CNC(C1)C(=O)Cn2c(c3ccc(Cl)cc3)c(C4CCCCC4)c5ccc(cc25)C(=O)O,IC50,=,13,nM,7.886056648,Q8JXU8,Hepatitis C virus NS5B RNA-dependent RNA polymerase,CHEMBL1140313,Scientific Literature,Inhibitory activity against by hepatitis C virus NS5B polymerase,15999993,J. Med. Chem.,2005,48,14,4547,508.05,3.16,74.57,1,Active
CHEMBL202319,OC1=C(C(=O)N(CCC2CC2)c3ccccc13)C4=NS(=O)(=O)c5ccccc5N4,IC50,=,13,nM,7.886056648,Q8JXU8,Hepatitis C virus NS5B RNA-dependent RNA polymerase,CHEMBL1148625,Scientific Literature,Inhibitory activity against HCV delta 21 NS5B RNA polymerase by SPA assay,16451063,J. Med. Chem.,2006,49,3,971,409.46,1.81,107.44,0,Active
CHEMBL211130,CC(C)CCN1C(=O)C(=C(O)c2cccnc12)C3=NS(=O)(=O)c4cc(NS(=O)(=O)NCc5cccc(c5)[N+](=O)[O-])ccc4N3,IC50,=,13,nM,7.886056648,Q8JXU8,Hepatitis C virus NS5B RNA-dependent RNA polymerase,CHEMBL1138070,Scientific Literature,Inhibition of HCV 1a NS5B RNA polymerase,16650764,Bioorg. Med. Chem. Lett.,2006,16,13,3367,641.68,1.34,232.73,2,Active
CHEMBL375133,CC(C)NC(=O)c1ccc(c(COc2ccc(c(F)c2)c3nc4cc(ccc4n3C5CCCCC5)C(=O)O)c1)c6ccc(Cl)cc6,IC50,=,13,nM,7.886056648,Q8JXU8,Hepatitis C virus NS5B RNA-dependent RNA polymerase,CHEMBL1138950,Scientific Literature,Inhibition of HCV 1b BK six His-tagged C-terminal truncated 544 amino acid NS5B RNA dependent RNA polymerase,16854079,J. Med. Chem.,2006,49,15,4721,640.14,8.85,93.45,2,Active
CHEMBL438430,NC(=O)c1ccc(c(COc2ccc(cc2)c3nc4cc(ccc4n3C5CCCCC5)C(=O)O)c1)c6ccc(Cl)cc6,IC50,=,13,nM,7.886056648,Q8JXU8,Hepatitis C virus NS5B RNA-dependent RNA polymerase,CHEMBL1138950,Scientific Literature,Inhibition of HCV 1b BK six His-tagged C-terminal truncated 544 amino acid NS5B RNA dependent RNA polymerase,16854079,J. Med. Chem.,2006,49,15,4721,580.07,7.72,107.44,2,Active
CHEMBL222231,COc1cc(OC)c(CCC2(CC(=C(Sc3nc4nc(C)cc(C)n4n3)C(=O)O2)O)C5CCCC5)cc1Cl,IC50,=,14,nM,7.853871964,Q8JXU8,Hepatitis C virus NS5B RNA-dependent RNA polymerase,CHEMBL1142138,Scientific Literature,Inhibition of recombinant HCV 1b BK NS5B polymerase by primer/template-directed transcription assay,17060518,Antimicrob. Agents Chemother.,2007,51,1,95,559.08,5.84,133.37,2,Active
CHEMBL368589,OC1CCN(CC1)C(=O)c2ccc(c(COc3ccc(c(F)c3)c4nc5cc(ccc5n4C6CCCCC6)C(=O)O)c2)c7ccc(Cl)cc7,IC50,=,14,nM,7.853871964,Q8JXU8,Hepatitis C virus NS5B RNA-dependent RNA polymerase,CHEMBL1138950,Scientific Literature,Inhibition of HCV 1b BK six His-tagged C-terminal truncated 544 amino acid NS5B RNA dependent RNA polymerase,16854079,J. Med. Chem.,2006,49,15,4721,682.18,7.77,104.89,2,Active
CHEMBL213695,CC(=O)Nc1ccc(c(COc2ccc(c(F)c2)c3nc4cc(ccc4n3C5CCCCC5)C(=O)O)c1)c6ccc(Cl)cc6,IC50,=,14,nM,7.853871964,Q8JXU8,Hepatitis C virus NS5B RNA-dependent RNA polymerase,CHEMBL1138950,Scientific Literature,Inhibition of HCV 1b BK six His-tagged C-terminal truncated 544 amino acid NS5B RNA dependent RNA polymerase,16854079,J. Med. Chem.,2006,49,15,4721,612.09,8.04,93.45,2,Active
CHEMBL210760,CNS(=O)(=O)Nc1ccc2N=C(NS(=O)(=O)c2c1)C3=C(O)c4cccnc4N(CCC(C)C)C3=O,IC50,=,14,nM,7.853871964,Q8JXU8,Hepatitis C virus NS5B RNA-dependent RNA polymerase,CHEMBL1138070,Scientific Literature,Inhibition of HCV 1a NS5B RNA polymerase,16650764,Bioorg. Med. Chem. Lett.,2006,16,13,3367,520.58,0.51,186.92,1,Active
CHEMBL379435,OC(=O)c1ccc2c(c1)nc(c3ccc(OCc4cc(ccc4c5ccc(Cl)cc5)C(=O)N6CCOCC6)cc3F)n2C7CCCCC7,IC50,=,14,nM,7.853871964,Q8JXU8,Hepatitis C virus NS5B RNA-dependent RNA polymerase,CHEMBL1138950,Scientific Literature,Inhibition of HCV 1b BK six His-tagged C-terminal truncated 544 amino acid NS5B RNA dependent RNA polymerase,16854079,J. Med. Chem.,2006,49,15,4721,668.15,8.02,93.89,2,Active
CHEMBL361232,CN(C)C(=O)Cn1c(c2ccc(Cl)cc2)c(C3CCCCC3)c4ccc(cc14)C(=O)O,IC50,=,15,nM,7.823908741,Q8JXU8,Hepatitis C virus NS5B RNA-dependent RNA polymerase,CHEMBL1142688,Scientific Literature,Inhibitory concentration against NS5B polymerase of Hepatitis C virus; n=1,15743173,J. Med. Chem.,2005,48,5,1314,438.95,5.89,62.54,1,Active
CHEMBL376688,CN(C)C(=O)c1ccc(c(COc2ccc(cc2)c3nc4cc(ccc4n3C5CCCCC5)C(=O)O)c1)c6ccc(Cl)cc6,IC50,=,15,nM,7.823908741,Q8JXU8,Hepatitis C virus NS5B RNA-dependent RNA polymerase,CHEMBL1138950,Scientific Literature,Inhibition of HCV 1b BK six His-tagged C-terminal truncated 544 amino acid NS5B RNA dependent RNA polymerase,16854079,J. Med. Chem.,2006,49,15,4721,608.13,8.13,84.66,2,Active
CHEMBL366575,OC(=O)[C@H](Cc1c[nH]c2ccc(cc12)C3N=NN=N3)NC(=O)c4ccc5c(c4)nc(c6cocc6)n5C7CCCCC7,IC50,=,15,nM,7.823908741,Q8JXU8,Hepatitis C virus NS5B RNA-dependent RNA polymerase,CHEMBL1149207,Scientific Literature,Concentration required for inhibiting hepatitis C virus NS5B RNA polymerase activity.,15013003,Bioorg. Med. Chem. Lett.,2004,14,4,967,564.59,7.12,162.58,2,Active
CHEMBL238897,COc1cccc(CNS(=O)(=O)Nc2ccc3NC(=NS(=O)(=O)c3c2)C4=C(O)c5cccnc5N(CCC(C)C)C4=O)c1,IC50,=,15,nM,7.823908741,Q8JXU8,Hepatitis C virus NS5B RNA-dependent RNA polymerase,CHEMBL1138070,Scientific Literature,Inhibition of HCV 1a NS5B RNA polymerase,16650764,Bioorg. Med. Chem. Lett.,2006,16,13,3367,626.7,2.08,196.14,1,Active
CHEMBL3651434,CNC(=O)c1c(oc2ccc(c(F)c12)c3cc(cc(F)c3C)C(=O)NC4(COC4)c5ccccn5)c6ccc(F)cc6,IC50,=,16,nM,7.795880017,Q8JXU8,Hepatitis C virus NS5B RNA-dependent RNA polymerase,CHEMBL3639184,BindingDB Database,BindingDB_Patents: Enzyme Assay. HCV NS5B enzyme assay.,NA,,2013,NA,NA,NA,571.55,5.41,93.46,2,Active
CHEMBL374567,CN(C(=O)C)c1ccc(c(COc2ccc(c(F)c2)c3nc4cc(ccc4n3C5CCCCC5)C(=O)O)c1)c6ccc(Cl)cc6,IC50,=,16,nM,7.795880017,Q8JXU8,Hepatitis C virus NS5B RNA-dependent RNA polymerase,CHEMBL1138950,Scientific Literature,Inhibition of HCV 1b BK six His-tagged C-terminal truncated 544 amino acid NS5B RNA dependent RNA polymerase,16854079,J. Med. Chem.,2006,49,15,4721,626.12,8.25,84.66,2,Active
CHEMBL386508,Cn1c(c2cocc2)c(C3CCCCC3)c4ccc(cc14)C(=O)O,IC50,=,16,nM,7.795880017,Q8JXU8,Hepatitis C virus NS5B RNA-dependent RNA polymerase,CHEMBL1146881,Scientific Literature,Inhibition of HCV 1b NS5B delta21 RNA dependent RNA polymerase by SPA,16908138,Bioorg. Med. Chem. Lett.,2006,16,19,4987,323.39,5.06,55.37,1,Active
CHEMBL378470,NS(=O)(=O)c1ccc(c(COc2ccc(cc2)c3nc4cc(ccc4n3C5CCCCC5)C(=O)O)c1)c6ccc(Cl)cc6,IC50,=,16,nM,7.795880017,Q8JXU8,Hepatitis C virus NS5B RNA-dependent RNA polymerase,CHEMBL1138950,Scientific Literature,Inhibition of HCV 1b BK six His-tagged C-terminal truncated 544 amino acid NS5B RNA dependent RNA polymerase,16854079,J. Med. Chem.,2006,49,15,4721,616.13,7.42,132.89,2,Active
CHEMBL179673,CN(C)C(=O)Cn1c(c2ccc(C)cc2)c(C3CCCCC3)c4ccc(cc14)C(=O)O,IC50,=,17,nM,7.769551079,Q8JXU8,Hepatitis C virus NS5B RNA-dependent RNA polymerase,CHEMBL1142688,Scientific Literature,Inhibitory activity against RNA dependent RNA polymerase nonstructural protein 5B in hepatitis C virus; n=1,15743173,J. Med. Chem.,2005,48,5,1314,418.53,5.71,62.54,1,Active
CHEMBL3651433,CNC(=O)c1c(oc2ccc(c(F)c12)c3cc(C(=O)NC4(COC4)c5ccccn5)c(OC)cc3C)c6ccc(F)cc6,IC50,=,17,nM,7.769551079,Q8JXU8,Hepatitis C virus NS5B RNA-dependent RNA polymerase,CHEMBL3639184,BindingDB Database,BindingDB_Patents: Enzyme Assay. HCV NS5B enzyme assay.,NA,,2013,NA,NA,NA,583.58,5.19,102.69,2,Active
CHEMBL386319,OC(=O)c1ccc2c(C3CCCCC3)c4c5ccc(OCc6ccccc6)cc5OCCn4c2c1,IC50,=,17,nM,7.769551079,Q8JXU8,Hepatitis C virus NS5B RNA-dependent RNA polymerase,CHEMBL1137351,Scientific Literature,Inhibition of HCV NS5B RNA polymerase,17125247,J. Med. Chem.,2006,49,24,6950,467.56,7.33,60.69,1,Active
CHEMBL191059,CN(C)C(=O)CN(C)C(=O)Cn1c(c2ccc(Cl)cc2)c(C3CCCCC3)c4ccc(cc14)C(=O)O,IC50,=,17,nM,7.769551079,Q8JXU8,Hepatitis C virus NS5B RNA-dependent RNA polymerase,CHEMBL1140313,Scientific Literature,Inhibitory activity against by hepatitis C virus NS5B polymerase,15999993,J. Med. Chem.,2005,48,14,4547,510.02,5.16,82.85,2,Active
CHEMBL361156,CN(C)C(=O)Cn1c(c2cccc(F)c2)c(C3CCCCC3)c4ccc(cc14)C(=O)O,IC50,=,18,nM,7.744727495,Q8JXU8,Hepatitis C virus NS5B RNA-dependent RNA polymerase,CHEMBL1142688,Scientific Literature,Inhibitory activity against RNA dependent RNA polymerase nonstructural protein 5B in hepatitis C virus; n=1,15743173,J. Med. Chem.,2005,48,5,1314,422.49,5.43,62.54,1,Active
CHEMBL179970,COc1ccc(cc1)c2c(C3CCCCC3)c4ccc(cc4n2CC(=O)N(C)C)C(=O)O,IC50,=,18,nM,7.744727495,Q8JXU8,Hepatitis C virus NS5B RNA-dependent RNA polymerase,CHEMBL1142688,Scientific Literature,Inhibitory activity against RNA dependent RNA polymerase nonstructural protein 5B in hepatitis C virus; n=1,15743173,J. Med. Chem.,2005,48,5,1314,434.53,5.21,71.77,1,Active
CHEMBL1204385,Cl.Cl.CN(C)CCN1CCn2c(c3ccccc13)c(C4CCCCC4)c5ccc(cc25)C(=O)O,IC50,=,18,nM,7.744727495,Q8JXU8,Hepatitis C virus NS5B RNA-dependent RNA polymerase,CHEMBL1137351,Scientific Literature,Inhibition of HCV NS5B RNA polymerase,17125247,J. Med. Chem.,2006,49,24,6950,431.57,3.04,48.71,0,Active
CHEMBL411712,OC(=O)c1ccc2c(c1)nc(c3ccc(OCc4cc(ccc4c5ccc(Cl)cc5)C(=O)N6CCCCC6)cc3F)n2C7CCCCC7,IC50,=,18,nM,7.744727495,Q8JXU8,Hepatitis C virus NS5B RNA-dependent RNA polymerase,CHEMBL1138950,Scientific Literature,Inhibition of HCV 1b BK six His-tagged C-terminal truncated 544 amino acid NS5B RNA dependent RNA polymerase,16854079,J. Med. Chem.,2006,49,15,4721,666.18,9.25,84.66,2,Active
CHEMBL211639,CNC(=O)c1ccc(c(COc2ccc(cc2)c3nc4cc(ccc4n3C5CCCCC5)C(=O)O)c1)c6ccc(Cl)cc6,IC50,=,18,nM,7.744727495,Q8JXU8,Hepatitis C virus NS5B RNA-dependent RNA polymerase,CHEMBL1138950,Scientific Literature,Inhibition of HCV 1b BK six His-tagged C-terminal truncated 544 amino acid NS5B RNA dependent RNA polymerase,16854079,J. Med. Chem.,2006,49,15,4721,594.1,7.92,93.45,2,Active
CHEMBL211849,CC(=O)c1ccc(c(COc2ccc(cc2)c3nc4cc(ccc4n3C5CCCCC5)C(=O)O)c1)c6ccc(Cl)cc6,IC50,=,18,nM,7.744727495,Q8JXU8,Hepatitis C virus NS5B RNA-dependent RNA polymerase,CHEMBL1138950,Scientific Literature,Inhibition of HCV 1b BK six His-tagged C-terminal truncated 544 amino acid NS5B RNA dependent RNA polymerase,16854079,J. Med. Chem.,2006,49,15,4721,579.08,8.45,81.42,2,Active
CHEMBL189054,CN(CC1CCCN(C)C1)C(=O)Cn2c(c3ccccc3)c(C4CCCCC4)c5ccc(cc25)C(=O)O,IC50,=,18,nM,7.744727495,Q8JXU8,Hepatitis C virus NS5B RNA-dependent RNA polymerase,CHEMBL1140313,Scientific Literature,Inhibitory activity against by hepatitis C virus NS5B polymerase,15999993,J. Med. Chem.,2005,48,14,4547,501.66,2.89,65.78,1,Active
CHEMBL364942,CN(C)C(=O)Cn1c(c2cccc(CN3CCCC(F)(F)C3)c2)c(C4CCCCC4)c5ccc(cc15)C(=O)O,IC50,=,18,nM,7.744727495,Q8JXU8,Hepatitis C virus NS5B RNA-dependent RNA polymerase,CHEMBL1140313,Scientific Literature,Inhibitory activity against by hepatitis C virus NS5B polymerase,15999993,J. Med. Chem.,2005,48,14,4547,537.64,2.96,65.78,1,Active
CHEMBL193242,CN(C)C1CCN(CC1)C(=O)Cn2c(C3=CCCCC3)c(C4CCCCC4)c5ccc(cc25)C(=O)O,IC50,=,18,nM,7.744727495,Q8JXU8,Hepatitis C virus NS5B RNA-dependent RNA polymerase,CHEMBL1140313,Scientific Literature,Inhibitory activity against by hepatitis C virus NS5B polymerase,15999993,J. Med. Chem.,2005,48,14,4547,491.66,2.72,65.78,0,Active
CHEMBL205341,CC(C)CCN1[C@H](C(=C(C1=O)C2=NS(=O)(=O)c3ccccc3N2)O)C(C)(C)C,IC50,=,18,nM,7.744727495,Q8JXU8,Hepatitis C virus NS5B RNA-dependent RNA polymerase,CHEMBL1146957,Scientific Literature,Inhibition of HCV NS5B RNA dependent RNA polymerase,16455253,Bioorg. Med. Chem. Lett.,2006,16,8,2205,405.51,2.16,107.45,0,Active
CHEMBL208817,CC(C)CCN1C(=O)C(=C(O)c2cccnc12)C3=NS(=O)(=O)c4cc(NS(=O)(=O)Nc5ccc(cc5)C(=O)N)ccc4N3,IC50,=,18,nM,7.744727495,Q8JXU8,Hepatitis C virus NS5B RNA-dependent RNA polymerase,CHEMBL1138070,Scientific Literature,Inhibition of HCV 1a NS5B RNA polymerase,16650764,Bioorg. Med. Chem. Lett.,2006,16,13,3367,625.68,0.45,230.01,1,Active
CHEMBL215056,CN1CCn2c(c3ccccc13)c(C4CCCCC4)c5ccc(cc25)C(=O)O,IC50,=,19,nM,7.721246399,Q8JXU8,Hepatitis C virus NS5B RNA-dependent RNA polymerase,CHEMBL1137351,Scientific Literature,Inhibition of HCV NS5B RNA polymerase,17125247,J. Med. Chem.,2006,49,24,6950,374.48,5.94,45.47,1,Active
CHEMBL366574,OC(=O)COc1ccc2[nH]cc(C[C@H](NC(=O)c3ccc4c(c3)nc(c5cocc5)n4C6CCCCC6)C(=O)O)c2c1,IC50,=,19,nM,7.721246399,Q8JXU8,Hepatitis C virus NS5B RNA-dependent RNA polymerase,CHEMBL1149207,Scientific Literature,Concentration required for inhibiting hepatitis C virus NS5B RNA polymerase activity.,15013003,Bioorg. Med. Chem. Lett.,2004,14,4,967,570.59,4.93,159.68,1,Active
CHEMBL377813,CCN(C(=O)C)c1ccc(c(COc2ccc(c(F)c2)c3nc4cc(ccc4n3C5CCCCC5)C(=O)O)c1)c6ccc(Cl)cc6,IC50,=,19,nM,7.721246399,Q8JXU8,Hepatitis C virus NS5B RNA-dependent RNA polymerase,CHEMBL1138950,Scientific Literature,Inhibition of HCV 1b BK six His-tagged C-terminal truncated 544 amino acid NS5B RNA dependent RNA polymerase,16854079,J. Med. Chem.,2006,49,15,4721,640.14,8.6,84.66,2,Active
CHEMBL362572,CS(=O)(=O)N1CCN(CC1)C(=O)Cn2c(c3ccccc3)c(C4CCCCC4)c5ccc(cc25)C(=O)O,IC50,=,19,nM,7.721246399,Q8JXU8,Hepatitis C virus NS5B RNA-dependent RNA polymerase,CHEMBL1140313,Scientific Literature,Inhibitory activity against by hepatitis C virus NS5B polymerase,15999993,J. Med. Chem.,2005,48,14,4547,523.64,4.23,108.3,1,Active
CHEMBL176905,OC(=O)[C@H](Cc1c[nH]c2ccc(cc12)C(=O)O)NC(=O)c3ccc4c(c3)nc(c5cocc5)n4C6CCCCC6,IC50,=,20,nM,7.698970004,Q8JXU8,Hepatitis C virus NS5B RNA-dependent RNA polymerase,CHEMBL1149207,Scientific Literature,Concentration required for inhibiting hepatitis C virus NS5B RNA polymerase activity.,15013003,Bioorg. Med. Chem. Lett.,2004,14,4,967,540.57,5.09,150.44,2,Active
CHEMBL378727,CC(C)CCN1C(=O)C(=C(O)c2cccnc12)C3=NS(=O)(=O)c4cc(NS(=O)(=O)Nc5ccc(cc5)C(=O)O)ccc4N3,IC50,=,20,nM,7.698970004,Q8JXU8,Hepatitis C virus NS5B RNA-dependent RNA polymerase,CHEMBL1138070,Scientific Literature,Inhibition of HCV 1a NS5B RNA polymerase,16650764,Bioorg. Med. Chem. Lett.,2006,16,13,3367,626.66,1.07,224.21,2,Active
CHEMBL208945,CC(C)CCN1C(=O)C(=C(O)c2cccnc12)C3=NS(=O)(=O)c4cc(NS(=O)(=O)NCCC(=O)N)ccc4N3,IC50,=,20,nM,7.698970004,Q8JXU8,Hepatitis C virus NS5B RNA-dependent RNA polymerase,CHEMBL1138070,Scientific Literature,Inhibition of HCV 1a NS5B RNA polymerase,16650764,Bioorg. Med. Chem. Lett.,2006,16,13,3367,577.63,-0.39,230.01,1,Active
CHEMBL202317,CC(C)CCN1C(=O)C(=C(O)c2cc(F)ccc12)C3=NS(=O)(=O)c4ccccc4N3,IC50,=,20,nM,7.698970004,Q8JXU8,Hepatitis C virus NS5B RNA-dependent RNA polymerase,CHEMBL1148625,Scientific Literature,Inhibitory activity against HCV delta 21 NS5B RNA polymerase by SPA assay,16451063,J. Med. Chem.,2006,49,3,971,429.46,2.39,107.44,0,Active
CHEMBL1203925,Cl.OC(=O)c1ccc2c(C3CCCCC3)c4c5ccccc5NCCn4c2c1,IC50,=,21,nM,7.677780705,Q8JXU8,Hepatitis C virus NS5B RNA-dependent RNA polymerase,CHEMBL1137351,Scientific Literature,Inhibition of HCV NS5B RNA polymerase,17125247,J. Med. Chem.,2006,49,24,6950,360.45,5.59,54.26,1,Active
CHEMBL202405,CC(C)(C)CCN1C(=O)C(=C(O)c2ccccc12)C3=NS(=O)(=O)c4ccccc4N3,IC50,=,21,nM,7.677780705,Q8JXU8,Hepatitis C virus NS5B RNA-dependent RNA polymerase,CHEMBL1148625,Scientific Literature,Inhibitory activity against HCV delta 21 NS5B RNA polymerase by SPA assay,16451063,J. Med. Chem.,2006,49,3,971,425.5,2.39,107.44,0,Active
CHEMBL380002,CC(C)N(C(=O)C)c1ccc(c(COc2ccc(c(F)c2)c3nc4cc(ccc4n3C5CCCCC5)C(=O)O)c1)c6ccc(Cl)cc6,IC50,=,21,nM,7.677780705,Q8JXU8,Hepatitis C virus NS5B RNA-dependent RNA polymerase,CHEMBL1138950,Scientific Literature,Inhibition of HCV 1b BK six His-tagged C-terminal truncated 544 amino acid NS5B RNA dependent RNA polymerase,16854079,J. Med. Chem.,2006,49,15,4721,654.17,8.97,84.66,2,Active
CHEMBL214365,CCCNC(=O)c1ccc(c(COc2ccc(c(F)c2)c3nc4cc(ccc4n3C5CCCCC5)C(=O)O)c1)c6ccc(Cl)cc6,IC50,=,21,nM,7.677780705,Q8JXU8,Hepatitis C virus NS5B RNA-dependent RNA polymerase,CHEMBL1138950,Scientific Literature,Inhibition of HCV 1b BK six His-tagged C-terminal truncated 544 amino acid NS5B RNA dependent RNA polymerase,16854079,J. Med. Chem.,2006,49,15,4721,640.14,9,93.45,2,Active
CHEMBL212728,CC(C)CCN1C(=O)C(=C(O)c2cccnc12)C3=NS(=O)(=O)c4cc(NS(=O)(=O)NC(=O)OCCN)ccc4N3,IC50,=,21,nM,7.677780705,Q8JXU8,Hepatitis C virus NS5B RNA-dependent RNA polymerase,CHEMBL1138070,Scientific Literature,Inhibition of HCV 1a NS5B RNA polymerase,16650764,Bioorg. Med. Chem. Lett.,2006,16,13,3367,593.63,0.11,239.23,2,Active
CHEMBL213807,OCCNC(=O)c1ccc(c(COc2ccc(c(F)c2)c3nc4cc(ccc4n3C5CCCCC5)C(=O)O)c1)c6ccc(Cl)cc6,IC50,=,21,nM,7.677780705,Q8JXU8,Hepatitis C virus NS5B RNA-dependent RNA polymerase,CHEMBL1138950,Scientific Literature,Inhibition of HCV 1b BK six His-tagged C-terminal truncated 544 amino acid NS5B RNA dependent RNA polymerase,16854079,J. Med. Chem.,2006,49,15,4721,642.12,7.59,113.68,2,Active
CHEMBL425221,CC(C)CCN1C(=O)C(=C(O)c2cc(NCC(=O)O)ccc12)C3=NS(=O)(=O)c4ccccc4N3,IC50,=,21,nM,7.677780705,Q8JXU8,Hepatitis C virus NS5B RNA-dependent RNA polymerase,CHEMBL1148625,Scientific Literature,Inhibitory activity against HCV delta 21 NS5B RNA polymerase by SPA assay,16451063,J. Med. Chem.,2006,49,3,971,484.52,1.47,156.77,0,Active
CHEMBL214864,Cn1c(c2cocc2)c(C3CCCC3)c4ccc(cc14)C(=O)O,IC50,=,21,nM,7.677780705,Q8JXU8,Hepatitis C virus NS5B RNA-dependent RNA polymerase,CHEMBL1146881,Scientific Literature,Inhibition of HCV 1b NS5B delta21 RNA dependent RNA polymerase by SPA,16908138,Bioorg. Med. Chem. Lett.,2006,16,19,4987,309.36,4.61,55.37,0,Active
CHEMBL379931,CC(=O)Nc1ccc(c(COc2ccc(cc2)c3nc4cc(ccc4n3C5CCCCC5)C(=O)O)c1)c6ccc(Cl)cc6,IC50,=,22,nM,7.657577319,Q8JXU8,Hepatitis C virus NS5B RNA-dependent RNA polymerase,CHEMBL1138950,Scientific Literature,Inhibition of HCV 1b BK six His-tagged C-terminal truncated 544 amino acid NS5B RNA dependent RNA polymerase,16854079,J. Med. Chem.,2006,49,15,4721,594.1,7.83,93.45,2,Active
CHEMBL3651436,CNC(=O)c1c(oc2ccc(c(F)c12)c3cc(C(=O)NC4(COC4)c5ncccn5)c(OC)cc3C)c6ccc(F)cc6,IC50,=,22,nM,7.657577319,Q8JXU8,Hepatitis C virus NS5B RNA-dependent RNA polymerase,CHEMBL3639184,BindingDB Database,BindingDB_Patents: Enzyme Assay. HCV NS5B enzyme assay.,NA,,2013,NA,NA,NA,584.57,4.24,115.58,1,Active
CHEMBL204628,CC(C)(C)[C@@H]1N(Cc2ccccc2)C(=O)C(=C1O)C3=NS(=O)(=O)c4ccccc4N3,IC50,=,22,nM,7.657577319,Q8JXU8,Hepatitis C virus NS5B RNA-dependent RNA polymerase,CHEMBL1146957,Scientific Literature,Inhibition of HCV NS5B RNA dependent RNA polymerase,16455253,Bioorg. Med. Chem. Lett.,2006,16,8,2205,425.5,2.81,107.45,0,Active
CHEMBL208585,CN(C)C(=O)Nc1ccc(c(COc2ccc(c(F)c2)c3nc4cc(ccc4n3C5CCCCC5)C(=O)O)c1)c6ccc(Cl)cc6,IC50,=,22,nM,7.657577319,Q8JXU8,Hepatitis C virus NS5B RNA-dependent RNA polymerase,CHEMBL1138950,Scientific Literature,Inhibition of HCV 1b BK six His-tagged C-terminal truncated 544 amino acid NS5B RNA dependent RNA polymerase,16854079,J. Med. Chem.,2006,49,15,4721,641.13,8.24,96.69,2,Active
CHEMBL379033,COc1ccc2N(CCC(C)C)C(=O)C(=C(O)c2c1)C3=NS(=O)(=O)c4ccccc4N3,IC50,=,23,nM,7.638272164,Q8JXU8,Hepatitis C virus NS5B RNA-dependent RNA polymerase,CHEMBL1148625,Scientific Literature,Inhibitory activity against HCV delta 21 NS5B RNA polymerase by SPA assay,16451063,J. Med. Chem.,2006,49,3,971,441.5,2.17,116.68,0,Active
CHEMBL378469,CN(C)S(=O)(=O)c1ccc(c(COc2ccc(cc2)c3nc4cc(ccc4n3C5CCCCC5)C(=O)O)c1)c6ccc(Cl)cc6,IC50,=,23,nM,7.638272164,Q8JXU8,Hepatitis C virus NS5B RNA-dependent RNA polymerase,CHEMBL1138950,Scientific Literature,Inhibition of HCV 1b BK six His-tagged C-terminal truncated 544 amino acid NS5B RNA dependent RNA polymerase,16854079,J. Med. Chem.,2006,49,15,4721,644.18,7.83,110.11,2,Active
CHEMBL3651432,CNC(=O)c1c(oc2ccc(c(F)c12)c3cc(ccc3C)C(=O)NC4(COC4)c5ccccn5)c6ccc(F)cc6,IC50,=,24,nM,7.619788758,Q8JXU8,Hepatitis C virus NS5B RNA-dependent RNA polymerase,CHEMBL3639184,BindingDB Database,BindingDB_Patents: Enzyme Assay. HCV NS5B enzyme assay.,NA,,2013,NA,NA,NA,553.56,5.21,93.46,2,Active
CHEMBL385407,CN(C)C(=O)CN1CCn2c(c3ccccc13)c(C4CCCCC4)c5ccc(cc25)C(=O)O,IC50,=,24,nM,7.619788758,Q8JXU8,Hepatitis C virus NS5B RNA-dependent RNA polymerase,CHEMBL1137351,Scientific Literature,Inhibition of HCV NS5B RNA polymerase,17125247,J. Med. Chem.,2006,49,24,6950,445.55,5.21,65.78,1,Active
CHEMBL210674,CC(C)CCN1C(=O)C(=C(O)c2cccnc12)C3=NS(=O)(=O)c4cc(NS(=O)(=O)NN5CCC5)ccc4N3,IC50,=,24,nM,7.619788758,Q8JXU8,Hepatitis C virus NS5B RNA-dependent RNA polymerase,CHEMBL1138070,Scientific Literature,Inhibition of HCV 1a NS5B RNA polymerase,16650764,Bioorg. Med. Chem. Lett.,2006,16,13,3367,561.63,0.11,190.15,1,Active
CHEMBL376462,OC(=O)c1ccc(c(COc2ccc(cc2)c3nc4cc(ccc4n3C5CCCCC5)C(=O)O)c1)c6ccc(Cl)cc6,IC50,=,24,nM,7.619788758,Q8JXU8,Hepatitis C virus NS5B RNA-dependent RNA polymerase,CHEMBL1138950,Scientific Literature,Inhibition of HCV 1b BK six His-tagged C-terminal truncated 544 amino acid NS5B RNA dependent RNA polymerase,16854079,J. Med. Chem.,2006,49,15,4721,581.06,8.34,101.65,2,Active
CHEMBL380686,CC(C)CCN1C(=O)C(=C(O)c2cc(OCC(=O)N)ccc12)C3=NS(=O)(=O)c4ccccc4N3,IC50,=,24,nM,7.619788758,Q8JXU8,Hepatitis C virus NS5B RNA-dependent RNA polymerase,CHEMBL1148625,Scientific Literature,Inhibitory activity against HCV delta 21 NS5B RNA polymerase by SPA assay,16451063,J. Med. Chem.,2006,49,3,971,484.52,1.02,159.76,0,Active
CHEMBL383960,OC(=O)c1ccc2c(C3CCCC3)c([nH]c2c1)c4cocc4,IC50,=,25,nM,7.602059991,Q8JXU8,Hepatitis C virus NS5B RNA-dependent RNA polymerase,CHEMBL1146881,Scientific Literature,Inhibition of HCV 1b NS5B delta21 RNA dependent RNA polymerase by SPA,16908138,Bioorg. Med. Chem. Lett.,2006,16,19,4987,295.33,4.4,66.22,0,Active
CHEMBL179532,OC(=O)c1ccc2c(C3CCCCC3)c(c4ccccc4)n(CC(=O)N5CCOCC5)c2c1,IC50,=,26,nM,7.585026652,Q8JXU8,Hepatitis C virus NS5B RNA-dependent RNA polymerase,CHEMBL1146030,Scientific Literature,Inhibition of HCV BK NS5B deltaC55 RNA dependent RNA polymerase,16714108,Bioorg. Med. Chem. Lett.,2006,16,15,4026,446.54,4.91,71.77,0,Active
CHEMBL216865,OC(=O)c1ccc2c(C3CCCCC3)c4c5ccccc5N(CCc6ccccc6)CCn4c2c1,IC50,=,26,nM,7.585026652,Q8JXU8,Hepatitis C virus NS5B RNA-dependent RNA polymerase,CHEMBL1137351,Scientific Literature,Inhibition of HCV NS5B RNA polymerase,17125247,J. Med. Chem.,2006,49,24,6950,464.6,7.85,45.47,1,Active
CHEMBL386726,OC(=O)c1ccc2c(C3CCCCC3)c4c5ccccc5OCCn4c2c1,IC50,=,26,nM,7.585026652,Q8JXU8,Hepatitis C virus NS5B RNA-dependent RNA polymerase,CHEMBL1137351,Scientific Literature,Inhibition of HCV NS5B RNA polymerase,17125247,J. Med. Chem.,2006,49,24,6950,361.43,5.76,51.45,1,Active
CHEMBL370203,OC1=C(C2=NS(=O)(=O)c3ccccc3N2)C(=O)N(Cc4cocc4)c5ccccc15,IC50,=,27,nM,7.568636236,Q8JXU8,Hepatitis C virus NS5B RNA-dependent RNA polymerase,CHEMBL1148625,Scientific Literature,Inhibitory activity against HCV delta 21 NS5B RNA polymerase by SPA assay,16451063,J. Med. Chem.,2006,49,3,971,421.43,1.29,120.58,0,Active
CHEMBL212200,CC(C)CCN1C(=O)C(=C(O)c2cccnc12)C3=NS(=O)(=O)c4cc(NS(=O)(=O)NN5CCCC5)ccc4N3,IC50,=,27,nM,7.568636236,Q8JXU8,Hepatitis C virus NS5B RNA-dependent RNA polymerase,CHEMBL1138070,Scientific Literature,Inhibition of HCV 1a NS5B RNA polymerase,16650764,Bioorg. Med. Chem. Lett.,2006,16,13,3367,575.66,0.69,190.15,1,Active
CHEMBL209853,OC(=O)c1ccc2c(c1)nc(c3ccc(OCc4cc(ccc4c5ccc(Cl)cc5)C(=O)NCc6ccccc6)cc3)n2C7CCCCC7,IC50,=,29,nM,7.537602002,Q8JXU8,Hepatitis C virus NS5B RNA-dependent RNA polymerase,CHEMBL1138950,Scientific Literature,Inhibition of HCV 1b BK six His-tagged C-terminal truncated 544 amino acid NS5B RNA dependent RNA polymerase,16854079,J. Med. Chem.,2006,49,15,4721,670.2,9.51,93.45,2,Active
CHEMBL425693,Cn1c(c2ccccc2)c(C3CCCCC3)c4ccc(cc14)C(=O)O,IC50,=,30,nM,7.522878745,Q8JXU8,Hepatitis C virus NS5B RNA-dependent RNA polymerase,CHEMBL1146881,Scientific Literature,Inhibition of HCV 1b NS5B delta21 RNA dependent RNA polymerase by SPA,16908138,Bioorg. Med. Chem. Lett.,2006,16,19,4987,333.42,5.96,42.23,1,Active
CHEMBL216000,OC(=O)c1ccc2c(C3CCCCC3)c([nH]c2c1)c4cocc4,IC50,=,30,nM,7.522878745,Q8JXU8,Hepatitis C virus NS5B RNA-dependent RNA polymerase,CHEMBL1146881,Scientific Literature,Inhibition of HCV 1b NS5B delta21 RNA dependent RNA polymerase by SPA,16908138,Bioorg. Med. Chem. Lett.,2006,16,19,4987,309.36,4.86,66.22,0,Active
CHEMBL366197,OC(=O)\C(=C\c1ccc(Oc2c(F)cccc2Br)cc1)\NC(=O)c3ccccc3,IC50,=,30,nM,7.522878745,Q8JXU8,Hepatitis C virus NS5B RNA-dependent RNA polymerase,CHEMBL1145278,Scientific Literature,Inhibitory concentration against RNA dependent RNA polymerase Nonstructural protein 5B (HCV NS5B polymerase) in Hepatitis C virus,15911260,Bioorg. Med. Chem. Lett.,2005,15,11,2812,456.26,4.93,75.63,0,Active
CHEMBL190558,CN(C)C(=O)Cn1c(c2cocc2)c(C3CCCCC3)c4ccc(cc14)C(=O)O,IC50,=,31,nM,7.508638306,Q8JXU8,Hepatitis C virus NS5B RNA-dependent RNA polymerase,CHEMBL1140313,Scientific Literature,Inhibitory activity against by hepatitis C virus NS5B polymerase,15999993,J. Med. Chem.,2005,48,14,4547,394.46,4.33,75.68,0,Active
CHEMBL212363,CC(C)C(=O)N(C)c1ccc(c(COc2ccc(c(F)c2)c3nc4cc(ccc4n3C5CCCCC5)C(=O)O)c1)c6ccc(Cl)cc6,IC50,=,32,nM,7.494850022,Q8JXU8,Hepatitis C virus NS5B RNA-dependent RNA polymerase,CHEMBL1138950,Scientific Literature,Inhibition of HCV 1b BK six His-tagged C-terminal truncated 544 amino acid NS5B RNA dependent RNA polymerase,16854079,J. Med. Chem.,2006,49,15,4721,654.17,9.38,84.66,2,Active
CHEMBL378218,CN(C)C(=O)c1ccc(COc2ccc(cc2)c3nc4cc(ccc4n3C5CCCCC5)C(=O)O)c(c1)c6ccc(Cl)cc6,IC50,=,32,nM,7.494850022,Q8JXU8,Hepatitis C virus NS5B RNA-dependent RNA polymerase,CHEMBL1138950,Scientific Literature,Inhibition of HCV 1b BK six His-tagged C-terminal truncated 544 amino acid NS5B RNA dependent RNA polymerase,16854079,J. Med. Chem.,2006,49,15,4721,608.13,8.13,84.66,2,Active
CHEMBL211044,CC(C)CCN1C(=O)C(=C(O)c2cccnc12)C3=NS(=O)(=O)c4cc(NS(=O)(=O)NC5CCNCC5)ccc4N3,IC50,=,32,nM,7.494850022,Q8JXU8,Hepatitis C virus NS5B RNA-dependent RNA polymerase,CHEMBL1138070,Scientific Literature,Inhibition of HCV 1a NS5B RNA polymerase,16650764,Bioorg. Med. Chem. Lett.,2006,16,13,3367,589.69,0.09,198.95,1,Active
CHEMBL203426,Nc1ccc2N(CCC3CC3)C(=O)C(=C(O)c2c1)C4=NS(=O)(=O)c5ccccc5N4,IC50,=,32,nM,7.494850022,Q8JXU8,Hepatitis C virus NS5B RNA-dependent RNA polymerase,CHEMBL1148625,Scientific Literature,Inhibitory activity against HCV delta 21 NS5B RNA polymerase by SPA assay,16451063,J. Med. Chem.,2006,49,3,971,424.47,1.06,133.47,0,Active
CHEMBL201558,CC(C)CCN1C(=O)C(=C(O)c2c(Cl)cccc12)C3=NS(=O)(=O)c4ccccc4N3,IC50,=,33,nM,7.48148606,Q8JXU8,Hepatitis C virus NS5B RNA-dependent RNA polymerase,CHEMBL1148625,Scientific Literature,Inhibitory activity against HCV delta 21 NS5B RNA polymerase by SPA assay,16451063,J. Med. Chem.,2006,49,3,971,445.92,2.85,107.44,0,Active
CHEMBL201690,CC(C)CCN1C(=O)C(=C(O)c2cc(OCC#N)ccc12)C3=NS(=O)(=O)c4ccccc4N3,IC50,=,34,nM,7.468521083,Q8JXU8,Hepatitis C virus NS5B RNA-dependent RNA polymerase,CHEMBL1148625,Scientific Literature,Inhibitory activity against HCV delta 21 NS5B RNA polymerase by SPA assay,16451063,J. Med. Chem.,2006,49,3,971,466.51,1.9,140.47,0,Active
CHEMBL201332,OC1=C(C2=NS(=O)(=O)c3ccccc3N2)C(=O)N(Cc4cccc(Br)c4)c5ccccc15,IC50,=,36,nM,7.443697499,Q8JXU8,Hepatitis C virus NS5B RNA-dependent RNA polymerase,CHEMBL1148625,Scientific Literature,Inhibitory activity against HCV delta 21 NS5B RNA polymerase by SPA assay,16451063,J. Med. Chem.,2006,49,3,971,510.36,2.93,107.44,1,Active
CHEMBL216143,CC(C)N1CCn2c(c3ccccc13)c(C4CCCCC4)c5ccc(cc25)C(=O)O,IC50,=,36,nM,7.443697499,Q8JXU8,Hepatitis C virus NS5B RNA-dependent RNA polymerase,CHEMBL1137351,Scientific Literature,Inhibition of HCV NS5B RNA polymerase,17125247,J. Med. Chem.,2006,49,24,6950,402.53,6.67,45.47,1,Active
CHEMBL424769,NC(=O)c1ccc2[nH]cc(C[C@H](NC(=O)c3ccc4c(c3)nc(c5cocc5)n4C6CCCCC6)C(=O)O)c2c1,IC50,=,37,nM,7.431798276,Q8JXU8,Hepatitis C virus NS5B RNA-dependent RNA polymerase,CHEMBL1149207,Scientific Literature,Concentration required for inhibiting hepatitis C virus NS5B RNA polymerase activity.,15013003,Bioorg. Med. Chem. Lett.,2004,14,4,967,539.58,4.46,156.23,1,Active
CHEMBL369320,OC(=O)c1ccc2c(C3CCCCC3)c(c4ccccc4)n(Cc5ccccc5)c2c1,IC50,=,37,nM,7.431798276,Q8JXU8,Hepatitis C virus NS5B RNA-dependent RNA polymerase,CHEMBL1142688,Scientific Literature,Inhibitory activity against RNA dependent RNA polymerase nonstructural protein 5B in hepatitis C virus; n=1,15743173,J. Med. Chem.,2005,48,5,1314,409.52,7.54,42.23,1,Active
CHEMBL215007,COc1ccc(CCC2(CC(=O)C(=C(O)O2)Sc3nncn3C)C4CCCC4)cc1Cl,IC50,=,38,nM,7.420216403,Q8JXU8,Hepatitis C virus NS5B RNA-dependent RNA polymerase,CHEMBL1149470,Scientific Literature,Inhibitory activity against HCV 1b BK NS5B deltaC21 RNA polymerase,16824756,Bioorg. Med. Chem. Lett.,2006,16,18,4834,463.98,4.9,111.77,0,Active
CHEMBL215708,OC(=O)c1ccc2c(C3CCCCC3)c4c5ccccc5SCCn4c2c1,IC50,=,38,nM,7.420216403,Q8JXU8,Hepatitis C virus NS5B RNA-dependent RNA polymerase,CHEMBL1137351,Scientific Literature,Inhibition of HCV NS5B RNA polymerase,17125247,J. Med. Chem.,2006,49,24,6950,377.5,6.32,67.53,1,Active
CHEMBL378748,CC(C)CCN1C(=O)C(=C(O)c2cccnc12)C3=NS(=O)(=O)c4cc(NS(=O)(=O)NC5CCCC5)ccc4N3,IC50,=,39,nM,7.408935393,Q8JXU8,Hepatitis C virus NS5B RNA-dependent RNA polymerase,CHEMBL1138070,Scientific Literature,Inhibition of HCV 1a NS5B RNA polymerase,16650764,Bioorg. Med. Chem. Lett.,2006,16,13,3367,574.67,1.91,186.92,1,Active
CHEMBL189744,CN1CCN(CC1)C(=O)Cn2c(c3ccccc3)c(C4CCCCC4)c5ccc(cc25)C(=O)O,IC50,=,39,nM,7.408935393,Q8JXU8,Hepatitis C virus NS5B RNA-dependent RNA polymerase,CHEMBL1140313,Scientific Literature,Inhibitory activity against by hepatitis C virus NS5B polymerase,15999993,J. Med. Chem.,2005,48,14,4547,459.58,2.15,65.78,0,Active
CHEMBL362834,CN(C)C(=O)Cn1c(c2cccc(Cl)c2)c(C3CCCCC3)c4ccc(cc14)C(=O)O,IC50,=,40,nM,7.397940009,Q8JXU8,Hepatitis C virus NS5B RNA-dependent RNA polymerase,CHEMBL1142688,Scientific Literature,Inhibitory activity against RNA dependent RNA polymerase nonstructural protein 5B in hepatitis C virus; n=1,15743173,J. Med. Chem.,2005,48,5,1314,438.95,5.89,62.54,1,Active
CHEMBL370679,OC(=O)\C(=C\c1ccc(Oc2ccccc2I)cc1)\NC(=O)c3ccccc3,IC50,=,40,nM,7.397940009,Q8JXU8,Hepatitis C virus NS5B RNA-dependent RNA polymerase,CHEMBL1140265,Scientific Literature,Inhibitory concentration against Hepatitis C virus NS5B polymerase,15863301,Bioorg. Med. Chem. Lett.,2005,15,10,2481,485.27,4.56,75.63,0,Active
CHEMBL440992,OC(=O)c1ccc2c(C3CCCCC3)c4c5ccccc5N(Cc6ccccc6)CCn4c2c1,IC50,=,41,nM,7.387216143,Q8JXU8,Hepatitis C virus NS5B RNA-dependent RNA polymerase,CHEMBL1137351,Scientific Literature,Inhibition of HCV NS5B RNA polymerase,17125247,J. Med. Chem.,2006,49,24,6950,450.57,7.52,45.47,1,Active
CHEMBL188698,CN(C)C1CCN(CC1)C(=O)Cn2c(c3ccccc3)c(C4CCCCC4)c5ccc(cc25)C(=O)O,IC50,=,41,nM,7.387216143,Q8JXU8,Hepatitis C virus NS5B RNA-dependent RNA polymerase,CHEMBL1140313,Scientific Literature,Inhibitory activity against by hepatitis C virus NS5B polymerase,15999993,J. Med. Chem.,2005,48,14,4547,487.63,2.3,65.78,0,Active
CHEMBL383733,CC(C)CCN1C(=O)C(=C(O)c2cccnc12)C3=NS(=O)(=O)c4cc(NS(=O)(=O)Nc5ccccc5)ccc4N3,IC50,=,41,nM,7.387216143,Q8JXU8,Hepatitis C virus NS5B RNA-dependent RNA polymerase,CHEMBL1138070,Scientific Literature,Inhibition of HCV 1a NS5B RNA polymerase,16650764,Bioorg. Med. Chem. Lett.,2006,16,13,3367,582.65,2.09,186.92,1,Active
CHEMBL203254,CC1CC1CN2C(=O)C(=C(O)c3ccccc23)C4=NS(=O)(=O)c5ccccc5N4,IC50,=,41,nM,7.387216143,Q8JXU8,Hepatitis C virus NS5B RNA-dependent RNA polymerase,CHEMBL1148625,Scientific Literature,Inhibitory activity against HCV delta 21 NS5B RNA polymerase by SPA assay,16451063,J. Med. Chem.,2006,49,3,971,409.46,1.67,107.44,0,Active
CHEMBL373786,OC(=O)c1ccc2c(c1)nc(c3ccc(OCc4cc(ccc4c5ccc(Cl)cc5)C#N)cc3)n2C6CCCCC6,IC50,=,41,nM,7.387216143,Q8JXU8,Hepatitis C virus NS5B RNA-dependent RNA polymerase,CHEMBL1138950,Scientific Literature,Inhibition of HCV 1b BK six His-tagged C-terminal truncated 544 amino acid NS5B RNA dependent RNA polymerase,16854079,J. Med. Chem.,2006,49,15,4721,562.06,8.59,88.14,2,Active
CHEMBL372235,OC(=O)c1ccc2c(C3CCCCC3)c(c4ccccc4)n(CC(=O)N5CCS(=O)(=O)CC5)c2c1,IC50,=,43,nM,7.366531544,Q8JXU8,Hepatitis C virus NS5B RNA-dependent RNA polymerase,CHEMBL1140313,Scientific Literature,Inhibitory activity against by hepatitis C virus NS5B polymerase,15999993,J. Med. Chem.,2005,48,14,4547,494.6,4.64,105.06,0,Active
CHEMBL201406,CC(C)CCN1C(=O)C(=C(O)c2cc(Cl)ccc12)C3=NS(=O)(=O)c4ccccc4N3,IC50,=,43,nM,7.366531544,Q8JXU8,Hepatitis C virus NS5B RNA-dependent RNA polymerase,CHEMBL1148625,Scientific Literature,Inhibitory activity against HCV delta 21 NS5B RNA polymerase by SPA assay,16451063,J. Med. Chem.,2006,49,3,971,445.92,2.85,107.44,0,Active
CHEMBL377394,CC(C)CCN1C(=O)C(=C(O)c2cccnc12)C3=NS(=O)(=O)c4cc(NS(=O)(=O)Nc5cccc(c5)C(=O)N)ccc4N3,IC50,=,43,nM,7.366531544,Q8JXU8,Hepatitis C virus NS5B RNA-dependent RNA polymerase,CHEMBL1138070,Scientific Literature,Inhibition of HCV 1a NS5B RNA polymerase,16650764,Bioorg. Med. Chem. Lett.,2006,16,13,3367,625.68,0.45,230.01,1,Active
CHEMBL208595,CC(C)CCN1C(=O)C(=C(O)c2cccnc12)C3=NS(=O)(=O)c4cc(NS(=O)(=O)Nc5cccc(c5)C(=O)NCC(=O)N)ccc4N3,IC50,=,43,nM,7.366531544,Q8JXU8,Hepatitis C virus NS5B RNA-dependent RNA polymerase,CHEMBL1138070,Scientific Literature,Inhibition of HCV 1a NS5B RNA polymerase,16650764,Bioorg. Med. Chem. Lett.,2006,16,13,3367,682.73,0.15,259.11,3,Active
CHEMBL241423,CNC(=O)c1ccc(NS(=O)(=O)Nc2ccc3NC(=NS(=O)(=O)c3c2)C4=C(O)c5cccnc5N(CCC(C)C)C4=O)cc1,IC50,=,43,nM,7.366531544,Q8JXU8,Hepatitis C virus NS5B RNA-dependent RNA polymerase,CHEMBL1138070,Scientific Literature,Inhibition of HCV 1a NS5B RNA polymerase,16650764,Bioorg. Med. Chem. Lett.,2006,16,13,3367,639.7,1.3,216.01,1,Active
CHEMBL202165,CC(CCN1C(=O)C(=C(O)c2ccccc12)C3=NS(=O)(=O)c4ccccc4N3)C(F)(F)F,IC50,=,44,nM,7.356547324,Q8JXU8,Hepatitis C virus NS5B RNA-dependent RNA polymerase,CHEMBL1148625,Scientific Literature,Inhibitory activity against HCV delta 21 NS5B RNA polymerase by SPA assay,16451063,J. Med. Chem.,2006,49,3,971,465.45,2.54,107.44,0,Active
CHEMBL215329,Cc1c(c2cocc2)n(C3CCCCC3)c4ccc(cc14)C(=O)O,IC50,=,44,nM,7.356547324,Q8JXU8,Hepatitis C virus NS5B RNA-dependent RNA polymerase,CHEMBL1146881,Scientific Literature,Inhibition of HCV 1b NS5B delta21 RNA dependent RNA polymerase by SPA,16908138,Bioorg. Med. Chem. Lett.,2006,16,19,4987,323.39,5.22,55.37,1,Active
CHEMBL174719,OC(=O)C(=O)\C=C(/O)\c1cccc(OCc2cc(Cl)cc(Cl)c2C#N)c1,IC50,=,45,nM,7.346787486,Q8JXU8,Hepatitis C virus NS5B RNA-dependent RNA polymerase,CHEMBL1139456,Scientific Literature,Inhibitory activity against Hepatitis C virus RNA dependent RNA polymerase nonstructural protein 5B,14695815,J. Med. Chem.,2004,47,1,14,392.19,4.04,107.62,0,Active
CHEMBL361202,CS(=O)(=O)NC(=O)Cn1c(c2ccccc2)c(C3CCCCC3)c4ccc(cc14)C(=O)O,IC50,=,45,nM,7.346787486,Q8JXU8,Hepatitis C virus NS5B RNA-dependent RNA polymerase,CHEMBL1142688,Scientific Literature,Inhibitory activity against RNA dependent RNA polymerase nonstructural protein 5B in hepatitis C virus; n=1,15743173,J. Med. Chem.,2005,48,5,1314,454.54,4.59,113.85,0,Active
CHEMBL216647,CC(C)(NC(=O)c1ccc2c(C3CCCCC3)c4c5ccccc5OCCn4c2c1)C(=O)O,IC50,=,46,nM,7.337242168,Q8JXU8,Hepatitis C virus NS5B RNA-dependent RNA polymerase,CHEMBL1137351,Scientific Literature,Inhibition of HCV NS5B RNA polymerase,17125247,J. Med. Chem.,2006,49,24,6950,446.54,5.62,80.56,1,Active
CHEMBL201600,CC(C)CCN1C(=O)C(=C(O)c2c(O)cccc12)C3=NS(=O)(=O)c4ccccc4N3,IC50,=,47,nM,7.327902142,Q8JXU8,Hepatitis C virus NS5B RNA-dependent RNA polymerase,CHEMBL1148625,Scientific Literature,Inhibitory activity against HCV delta 21 NS5B RNA polymerase by SPA assay,16451063,J. Med. Chem.,2006,49,3,971,427.47,1.94,127.68,0,Active
CHEMBL188218,CN(CC1CCCN(C)C1)C(=O)Cn2c(c3ccccc3)c(C4CCCC4)c5ccc(cc25)C(=O)O,IC50,=,47,nM,7.327902142,Q8JXU8,Hepatitis C virus NS5B RNA-dependent RNA polymerase,CHEMBL1140313,Scientific Literature,Inhibitory activity against by hepatitis C virus NS5B polymerase,15999993,J. Med. Chem.,2005,48,14,4547,487.63,2.43,65.78,0,Active
CHEMBL217259,OC(=O)c1ccc2C(=C3C(CCCOc4ccccc34)c2c1)C5CCCCC5,IC50,=,47,nM,7.327902142,Q8JXU8,Hepatitis C virus NS5B RNA-dependent RNA polymerase,CHEMBL1137351,Scientific Literature,Inhibition of HCV NS5B RNA polymerase,17125247,J. Med. Chem.,2006,49,24,6950,374.47,5.98,46.53,1,Active
CHEMBL201769,CC(C)CCN1C(=O)C(=C(O)c2cc(C)ccc12)C3=NS(=O)(=O)c4ccccc4N3,IC50,=,47,nM,7.327902142,Q8JXU8,Hepatitis C virus NS5B RNA-dependent RNA polymerase,CHEMBL1148625,Scientific Literature,Inhibitory activity against HCV delta 21 NS5B RNA polymerase by SPA assay,16451063,J. Med. Chem.,2006,49,3,971,425.5,2.67,107.44,0,Active
CHEMBL240779,COC(=O)c1ccc(NS(=O)(=O)Nc2ccc3NC(=NS(=O)(=O)c3c2)C4=C(O)c5cccnc5N(CCC(C)C)C4=O)cc1,IC50,=,48,nM,7.318758763,Q8JXU8,Hepatitis C virus NS5B RNA-dependent RNA polymerase,CHEMBL1138070,Scientific Literature,Inhibition of HCV 1a NS5B RNA polymerase,16650764,Bioorg. Med. Chem. Lett.,2006,16,13,3367,640.69,1.94,213.21,2,Active
CHEMBL368884,OC(=O)c1ccc2c(C3CCCCC3)c([nH]c2c1)c4ccccc4,IC50,=,48,nM,7.318758763,Q8JXU8,Hepatitis C virus NS5B RNA-dependent RNA polymerase,CHEMBL1146030,Scientific Literature,Inhibition of HCV BK NS5B deltaC55 RNA dependent RNA polymerase,16714108,Bioorg. Med. Chem. Lett.,2006,16,15,4026,319.4,5.75,53.09,1,Active
CHEMBL202595,CC(C)(C)CCN1C(=O)C(=C(O)c2cc(NCCO)ccc12)C3=NS(=O)(=O)c4ccccc4N3,IC50,=,48,nM,7.318758763,Q8JXU8,Hepatitis C virus NS5B RNA-dependent RNA polymerase,CHEMBL1148625,Scientific Literature,Inhibitory activity against HCV delta 21 NS5B RNA polymerase by SPA assay,16451063,J. Med. Chem.,2006,49,3,971,484.57,1.66,139.7,0,Active
CHEMBL201385,OC1=C(C(=O)N(CC2CCC2)c3ccccc13)C4=NS(=O)(=O)c5ccccc5N4,IC50,=,49,nM,7.30980392,Q8JXU8,Hepatitis C virus NS5B RNA-dependent RNA polymerase,CHEMBL1148625,Scientific Literature,Inhibitory activity against HCV delta 21 NS5B RNA polymerase by SPA assay,16451063,J. Med. Chem.,2006,49,3,971,409.46,1.88,107.44,0,Active
CHEMBL188969,CN(C)C1CCN(CC1)C(=O)Cn2c(C=C)c(C3CCCCC3)c4ccc(cc24)C(=O)O,IC50,=,49,nM,7.30980392,Q8JXU8,Hepatitis C virus NS5B RNA-dependent RNA polymerase,CHEMBL1140313,Scientific Literature,Inhibitory activity against by hepatitis C virus NS5B polymerase,15999993,J. Med. Chem.,2005,48,14,4547,437.57,1.34,65.78,0,Active
CHEMBL198718,OC(=O)C(=O)\C=C(/O)\c1cccc(NS(=O)(=O)c2cc(Cl)c(Cl)cc2Cl)c1,IC50,=,49,nM,7.30980392,Q8JXU8,Hepatitis C virus NS5B RNA-dependent RNA polymerase,CHEMBL1140440,Scientific Literature,"Inhibitory concentration against NS5B HCV polymerase using [alpha-32P]UTP as radioligand (30 degree C for 2 h, at pH 7.5 with Tris-HCl buffer)",16190757,J. Med. Chem.,2005,48,20,6304,450.68,3.75,129.15,0,Active
CHEMBL209425,OC(=O)c1ccc2c(c1)nc(c3ccc(OCc4ccccc4c5ccc(Cl)cc5)cc3)n2C6CCCCC6,IC50,=,50,nM,7.301029996,Q8JXU8,Hepatitis C virus NS5B RNA-dependent RNA polymerase,CHEMBL1138950,Scientific Literature,Inhibition of HCV 1b BK six His-tagged C-terminal truncated 544 amino acid NS5B RNA dependent RNA polymerase,16854079,J. Med. Chem.,2006,49,15,4721,537.05,8.71,64.35,2,Active
CHEMBL367225,OC(=O)[C@H](Cc1c[nH]c2ccc(O)cc12)NC(=O)c3ccc4c(c3)nc(c5cocc5)n4C6CCCCC6,IC50,=,50,nM,7.301029996,Q8JXU8,Hepatitis C virus NS5B RNA-dependent RNA polymerase,CHEMBL1149207,Scientific Literature,Concentration required for inhibiting hepatitis C virus NS5B RNA polymerase activity.,15013003,Bioorg. Med. Chem. Lett.,2004,14,4,967,512.56,5.22,133.38,2,Active
CHEMBL380997,CCC[C@]1(CC(=O)O)OCCc2c1sc3c(C)cc(F)c(C#N)c23,IC50,=,50,nM,7.301029996,Q8JXU8,Hepatitis C virus NS5B RNA-dependent RNA polymerase,CHEMBL1148590,Scientific Literature,Displacement of [alpha-32P]GTP from recombinant HCV NS5B RNA dependent RNA polymerase,16274990,Bioorg. Med. Chem. Lett.,2006,16,2,457,347.4,4.38,98.56,0,Active
CHEMBL211507,OC(=O)c1ccc2c(c1)nc(c3ccc(OCc4cc(Cl)ccc4c5ccc(Cl)cc5)cc3)n2C6CCCCC6,IC50,=,50,nM,7.301029996,Q8JXU8,Hepatitis C virus NS5B RNA-dependent RNA polymerase,CHEMBL1138950,Scientific Literature,Inhibition of HCV 1b BK six His-tagged C-terminal truncated 544 amino acid NS5B RNA dependent RNA polymerase,16854079,J. Med. Chem.,2006,49,15,4721,571.49,9.38,64.35,2,Active
CHEMBL365135,CCc1ccccc1C(=O)N\C(=C/c2ccc(Oc3ccccc3Br)cc2)\C(=O)O,IC50,=,50,nM,7.301029996,Q8JXU8,Hepatitis C virus NS5B RNA-dependent RNA polymerase,CHEMBL1145278,Scientific Literature,Inhibitory concentration against RNA dependent RNA polymerase Nonstructural protein 5B (HCV NS5B polymerase) in Hepatitis C virus,15911260,Bioorg. Med. Chem. Lett.,2005,15,11,2812,466.32,5.67,75.63,1,Active
CHEMBL377356,CC(C)CCN1C(=O)C(=C(O)c2cccnc12)C3=NS(=O)(=O)c4cc(NS(=O)(=O)NC(=O)OCC(=O)O)ccc4N3,IC50,=,50,nM,7.301029996,Q8JXU8,Hepatitis C virus NS5B RNA-dependent RNA polymerase,CHEMBL1138070,Scientific Literature,Inhibition of HCV 1a NS5B RNA polymerase,16650764,Bioorg. Med. Chem. Lett.,2006,16,13,3367,608.6,0.42,250.51,2,Active
CHEMBL216863,Cn1c(c2cocc2)c(C3CCCCC3)c4ccc(nc14)C(=O)O,IC50,=,51,nM,7.292429824,Q8JXU8,Hepatitis C virus NS5B RNA-dependent RNA polymerase,CHEMBL1146881,Scientific Literature,Inhibition of HCV 1b NS5B delta21 RNA dependent RNA polymerase by SPA,16908138,Bioorg. Med. Chem. Lett.,2006,16,19,4987,324.37,4.54,68.25,0,Active
CHEMBL212582,OC(=O)c1ccc2c(c1)nc(c3ccc(OCc4cccnc4c5ccc(Cl)cc5)cc3)n2C6CCCCC6,IC50,=,53,nM,7.27572413,Q8JXU8,Hepatitis C virus NS5B RNA-dependent RNA polymerase,CHEMBL1138950,Scientific Literature,Inhibition of HCV 1b BK six His-tagged C-terminal truncated 544 amino acid NS5B RNA dependent RNA polymerase,16854079,J. Med. Chem.,2006,49,15,4721,538.04,7.99,77.24,2,Active
CHEMBL201456,CSCCN1C(=O)C(=C(O)c2ccccc12)C3=NS(=O)(=O)c4ccccc4N3,IC50,=,53,nM,7.27572413,Q8JXU8,Hepatitis C virus NS5B RNA-dependent RNA polymerase,CHEMBL1148625,Scientific Literature,Inhibitory activity against HCV delta 21 NS5B RNA polymerase by SPA assay,16451063,J. Med. Chem.,2006,49,3,971,415.49,1.22,132.75,0,Active
CHEMBL209681,OC(=O)c1ccc2c(c1)nc(c3ccc(OCc4cc(Cl)ccc4c5ccc(cc5)C#N)cc3)n2C6CCCCC6,IC50,=,55,nM,7.259637311,Q8JXU8,Hepatitis C virus NS5B RNA-dependent RNA polymerase,CHEMBL1138950,Scientific Literature,Inhibition of HCV 1b BK six His-tagged C-terminal truncated 544 amino acid NS5B RNA dependent RNA polymerase,16854079,J. Med. Chem.,2006,49,15,4721,562.06,8.59,88.14,2,Active
CHEMBL372590,OC(=O)C(=O)\C=C(/O)\c1cccc(OCc2cc(Cl)c(Cl)cc2C#N)c1,IC50,=,56,nM,7.251811973,Q8JXU8,Hepatitis C virus NS5B RNA-dependent RNA polymerase,CHEMBL1140440,Scientific Literature,"Inhibitory concentration against NS5B HCV polymerase using [alpha-32P]UTP as radioligand (30 degree C for 2 h, at pH 7.5 with Tris-HCl buffer)",16190757,J. Med. Chem.,2005,48,20,6304,392.19,4.04,107.62,0,Active
CHEMBL394033,COc1ccccc1CNS(=O)(=O)Nc2ccc3NC(=NS(=O)(=O)c3c2)C4=C(O)c5cccnc5N(CCC(C)C)C4=O,IC50,=,57,nM,7.244125144,Q8JXU8,Hepatitis C virus NS5B RNA-dependent RNA polymerase,CHEMBL1138070,Scientific Literature,Inhibition of HCV 1a NS5B RNA polymerase,16650764,Bioorg. Med. Chem. Lett.,2006,16,13,3367,626.7,2.08,196.14,1,Active
CHEMBL3651431,CNC(=O)c1c(oc2ccc(c(F)c12)c3cc(ccc3C)C(=O)NC4(COC4)c5ccccc5)c6ccc(F)cc6,IC50,=,57,nM,7.244125144,Q8JXU8,Hepatitis C virus NS5B RNA-dependent RNA polymerase,CHEMBL3639184,BindingDB Database,BindingDB_Patents: Enzyme Assay. HCV NS5B enzyme assay.,NA,,2013,NA,NA,NA,552.57,5.93,80.57,2,Active
CHEMBL211004,CC(C)CCN1C(=O)C(=C(O)c2cccnc12)C3=NS(=O)(=O)c4cc(NS(=O)(=O)NC(=O)OCc5ccccc5)ccc4N3,IC50,=,58,nM,7.236572006,Q8JXU8,Hepatitis C virus NS5B RNA-dependent RNA polymerase,CHEMBL1138070,Scientific Literature,Inhibition of HCV 1a NS5B RNA polymerase,16650764,Bioorg. Med. Chem. Lett.,2006,16,13,3367,640.69,1.88,213.21,2,Active
CHEMBL373930,OC(=O)c1ccc(cc1)c2ccc(Cl)cc2COc3ccc(cc3)c4nc5cc(ccc5n4C6CCCCC6)C(=O)O,IC50,=,58,nM,7.236572006,Q8JXU8,Hepatitis C virus NS5B RNA-dependent RNA polymerase,CHEMBL1138950,Scientific Literature,Inhibition of HCV 1b BK six His-tagged C-terminal truncated 544 amino acid NS5B RNA dependent RNA polymerase,16854079,J. Med. Chem.,2006,49,15,4721,581.06,8.34,101.65,2,Active
CHEMBL213832,CN(C)C(=O)Cn1c(c2ccccc2)c(C3CCCCC3)c4sc(cc14)C(=O)O,IC50,=,58,nM,7.236572006,Q8JXU8,Hepatitis C virus NS5B RNA-dependent RNA polymerase,CHEMBL1146030,Scientific Literature,Inhibition of HCV BK NS5B deltaC55 RNA dependent RNA polymerase,16714108,Bioorg. Med. Chem. Lett.,2006,16,15,4026,410.53,5.47,90.77,1,Active
CHEMBL180772,CCC(CC)CN1C(=O)C(=C(O)c2cccnc12)C3=NS(=O)(=O)c4ccccc4N3,IC50,=,58,nM,7.236572006,Q8JXU8,Hepatitis C virus NS5B RNA-dependent RNA polymerase,CHEMBL1142034,Scientific Literature,Inhibitory concentration against RNA dependent RNA polymerase Nonstructural protein 5B of genotype 1b Hepatitis C virus,15745800,Bioorg. Med. Chem. Lett.,2005,15,6,1577,426.49,2.09,120.34,0,Active
CHEMBL178126,CN(C)C(=O)Cn1c(c2ccccc2)c(C3CCCCC3)c4ccc(cc14)C(=O)O,IC50,=,59,nM,7.229147988,Q8JXU8,Hepatitis C virus NS5B RNA-dependent RNA polymerase,CHEMBL1142688,Scientific Literature,Inhibitory activity against RNA dependent RNA polymerase nonstructural protein 5B in hepatitis C virus; n=1,15743173,J. Med. Chem.,2005,48,5,1314,404.5,5.23,62.54,1,Active
CHEMBL381613,CC(C)(C)[C@@H]1N(Cc2ccc(F)cc2)C(=O)C(=C1O)C3=NS(=O)(=O)c4ccccc4N3,IC50,=,59,nM,7.229147988,Q8JXU8,Hepatitis C virus NS5B RNA-dependent RNA polymerase,CHEMBL1146957,Scientific Literature,Inhibition of HCV NS5B RNA dependent RNA polymerase,16455253,Bioorg. Med. Chem. Lett.,2006,16,8,2205,443.49,3.02,107.45,0,Active
CHEMBL174670,CC(=O)Nc1ccc2[nH]cc(C[C@H](NC(=O)c3ccc4c(c3)nc(c5cocc5)n4C6CCCCC6)C(=O)O)c2c1,IC50,=,60,nM,7.22184875,Q8JXU8,Hepatitis C virus NS5B RNA-dependent RNA polymerase,CHEMBL1149207,Scientific Literature,Concentration required for inhibiting hepatitis C virus NS5B RNA polymerase activity.,15013003,Bioorg. Med. Chem. Lett.,2004,14,4,967,553.61,4.58,142.24,1,Active
CHEMBL371345,OC(=O)CNC(=O)\C(=C\c1ccc(Oc2ccccc2Br)cc1)\NC(=O)c3ccccc3,IC50,=,60,nM,7.22184875,Q8JXU8,Hepatitis C virus NS5B RNA-dependent RNA polymerase,CHEMBL1145278,Scientific Literature,Inhibitory concentration against RNA dependent RNA polymerase Nonstructural protein 5B (HCV NS5B polymerase) in Hepatitis C virus,15911260,Bioorg. Med. Chem. Lett.,2005,15,11,2812,495.32,3.79,104.73,0,Active
CHEMBL201337,OC1=C(C2=NS(=O)(=O)c3ccccc3N2)C(=O)N(Cc4ccncc4)c5ccccc15,IC50,=,61,nM,7.214670165,Q8JXU8,Hepatitis C virus NS5B RNA-dependent RNA polymerase,CHEMBL1148625,Scientific Literature,Inhibitory activity against HCV delta 21 NS5B RNA polymerase by SPA assay,16451063,J. Med. Chem.,2006,49,3,971,432.45,1.03,120.33,0,Active
CHEMBL379184,CCOC(=O)COC(=O)NS(=O)(=O)Nc1ccc2N=C(NS(=O)(=O)c2c1)C3=C(O)c4cccnc4N(CCC(C)C)C3=O,IC50,=,61,nM,7.214670165,Q8JXU8,Hepatitis C virus NS5B RNA-dependent RNA polymerase,CHEMBL1138070,Scientific Literature,Inhibition of HCV 1a NS5B RNA polymerase,16650764,Bioorg. Med. Chem. Lett.,2006,16,13,3367,636.65,1,239.51,2,Active
CHEMBL191446,CC(C)N(C)C(=O)Cn1c(c2ccccc2)c(C3CCCCC3)c4ccc(cc14)C(=O)O,IC50,=,62,nM,7.207608311,Q8JXU8,Hepatitis C virus NS5B RNA-dependent RNA polymerase,CHEMBL1140313,Scientific Literature,Inhibitory activity against by hepatitis C virus NS5B polymerase,15999993,J. Med. Chem.,2005,48,14,4547,432.55,5.95,62.54,1,Active
CHEMBL426302,CC(C)CCN1C(=O)C(=C(O)c2cc(N)ccc12)C3=NS(=O)(=O)c4ccccc4N3,IC50,=,62,nM,7.207608311,Q8JXU8,Hepatitis C virus NS5B RNA-dependent RNA polymerase,CHEMBL1148625,Scientific Literature,Inhibitory activity against HCV delta 21 NS5B RNA polymerase by SPA assay,16451063,J. Med. Chem.,2006,49,3,971,426.49,1.44,133.47,0,Active
CHEMBL241629,COC(=O)NS(=O)(=O)Nc1ccc2NC(=NS(=O)(=O)c2c1)C3=C(O)c4cccnc4N(CCC(C)C)C3=O,IC50,=,63,nM,7.200659451,Q8JXU8,Hepatitis C virus NS5B RNA-dependent RNA polymerase,CHEMBL1138070,Scientific Literature,Inhibition of HCV 1a NS5B RNA polymerase,16650764,Bioorg. Med. Chem. Lett.,2006,16,13,3367,564.59,0.94,213.21,2,Active
CHEMBL211213,CN(C)c1ccc(c(COc2ccc(cc2)c3nc4cc(ccc4n3C5CCCCC5)C(=O)O)c1)c6ccc(Cl)cc6,IC50,=,63,nM,7.200659451,Q8JXU8,Hepatitis C virus NS5B RNA-dependent RNA polymerase,CHEMBL1138950,Scientific Literature,Inhibition of HCV 1b BK six His-tagged C-terminal truncated 544 amino acid NS5B RNA dependent RNA polymerase,16854079,J. Med. Chem.,2006,49,15,4721,580.12,8.88,67.59,2,Active
CHEMBL364269,OC(=O)c1ccc2c(C3CCCCC3)c(c4ccccc4)n(CC(=O)NCC5CC5)c2c1,IC50,=,63,nM,7.200659451,Q8JXU8,Hepatitis C virus NS5B RNA-dependent RNA polymerase,CHEMBL1140313,Scientific Literature,Inhibitory activity against by hepatitis C virus NS5B polymerase,15999993,J. Med. Chem.,2005,48,14,4547,430.54,5.84,71.33,1,Active
CHEMBL377275,CCC(C)CCN1C(=O)C(=C(O)c2ccccc12)C3=NS(=O)(=O)c4ccccc4N3,IC50,=,65,nM,7.187086643,Q8JXU8,Hepatitis C virus NS5B RNA-dependent RNA polymerase,CHEMBL1148625,Scientific Literature,Inhibitory activity against HCV delta 21 NS5B RNA polymerase by SPA assay,16451063,J. Med. Chem.,2006,49,3,971,425.5,2.64,107.44,0,Active
CHEMBL386744,OC(=O)c1cc2[nH]c(c3ccccc3)c(C4CCCCC4)c2s1,IC50,=,66,nM,7.180456064,Q8JXU8,Hepatitis C virus NS5B RNA-dependent RNA polymerase,CHEMBL1146030,Scientific Literature,Inhibition of HCV BK NS5B deltaC55 RNA dependent RNA polymerase,16714108,Bioorg. Med. Chem. Lett.,2006,16,15,4026,325.42,6,81.33,1,Active
CHEMBL384446,CC(C)CCN1C(=O)C(=C(O)c2cccnc12)C3=NS(=O)(=O)c4cc(NS(=O)(=O)NC5CCCCC5)ccc4N3,IC50,=,67,nM,7.173925197,Q8JXU8,Hepatitis C virus NS5B RNA-dependent RNA polymerase,CHEMBL1138070,Scientific Literature,Inhibition of HCV 1a NS5B RNA polymerase,16650764,Bioorg. Med. Chem. Lett.,2006,16,13,3367,588.7,2.37,186.92,1,Active
CHEMBL189534,CN1CCN(CC1)C(=O)Cn2c(c3ccccc3)c(C4CCCC4)c5ccc(cc25)C(=O)O,IC50,=,68,nM,7.167491087,Q8JXU8,Hepatitis C virus NS5B RNA-dependent RNA polymerase,CHEMBL1140313,Scientific Literature,Inhibitory activity against by hepatitis C virus NS5B polymerase,15999993,J. Med. Chem.,2005,48,14,4547,445.55,1.69,65.78,0,Active
CHEMBL377889,NC(=O)c1ccc(cc1)c2ccc(Cl)cc2COc3ccc(cc3)c4nc5cc(ccc5n4C6CCCCC6)C(=O)O,IC50,=,69,nM,7.161150909,Q8JXU8,Hepatitis C virus NS5B RNA-dependent RNA polymerase,CHEMBL1138950,Scientific Literature,Inhibition of HCV 1b BK six His-tagged C-terminal truncated 544 amino acid NS5B RNA dependent RNA polymerase,16854079,J. Med. Chem.,2006,49,15,4721,580.07,7.72,107.44,2,Active
CHEMBL439848,COc1ccc(cn1)c2c(C3CCCCC3)c4ccc(cc4n2CC(=O)N(C)C)C(=O)O,IC50,=,69,nM,7.161150909,Q8JXU8,Hepatitis C virus NS5B RNA-dependent RNA polymerase,CHEMBL1140313,Scientific Literature,Inhibitory activity against by hepatitis C virus NS5B polymerase,15999993,J. Med. Chem.,2005,48,14,4547,435.52,4.6,84.66,0,Active
CHEMBL193427,OC(=O)\C(=C\c1ccc(Oc2c(F)cccc2Cl)cc1)\NC(=O)c3ccccc3,IC50,=,70,nM,7.15490196,Q8JXU8,Hepatitis C virus NS5B RNA-dependent RNA polymerase,CHEMBL1140265,Scientific Literature,Inhibitory concentration against Hepatitis C virus NS5B polymerase,15863301,Bioorg. Med. Chem. Lett.,2005,15,10,2481,411.81,4.85,75.63,0,Active
CHEMBL191820,OC(=O)\C(=C\c1ccc(Oc2ccccc2Br)cc1)\NC(=O)C34CC5CC(CC(C5)C3)C4,IC50,=,70,nM,7.15490196,Q8JXU8,Hepatitis C virus NS5B RNA-dependent RNA polymerase,CHEMBL1145278,Scientific Literature,Inhibitory concentration against RNA dependent RNA polymerase Nonstructural protein 5B (HCV NS5B polymerase) in Hepatitis C virus,15911260,Bioorg. Med. Chem. Lett.,2005,15,11,2812,496.39,5.62,75.63,1,Active
CHEMBL187653,CN(C)C1CNC(C1)C(=O)Cn2c(c3ccccc3)c(C4CCCCC4)c5ccc(cc25)C(=O)O,IC50,=,71,nM,7.148741651,Q8JXU8,Hepatitis C virus NS5B RNA-dependent RNA polymerase,CHEMBL1140313,Scientific Literature,Inhibitory activity against by hepatitis C virus NS5B polymerase,15999993,J. Med. Chem.,2005,48,14,4547,473.61,2.49,74.57,0,Active
CHEMBL364941,CN(C)C1CCN(CC1)C(=O)Cn2c(C3CCCCC3)c(C4CCCCC4)c5ccc(cc25)C(=O)O,IC50,=,72,nM,7.142667504,Q8JXU8,Hepatitis C virus NS5B RNA-dependent RNA polymerase,CHEMBL1140313,Scientific Literature,Inhibitory activity against by hepatitis C virus NS5B polymerase,15999993,J. Med. Chem.,2005,48,14,4547,493.68,2.76,65.78,0,Active
CHEMBL209357,CC(C)CCN1C(=O)C(=C(O)c2cccnc12)C3=NS(=O)(=O)c4cc(NS(=O)(=O)NC(=O)OCC#C)ccc4N3,IC50,=,72,nM,7.142667504,Q8JXU8,Hepatitis C virus NS5B RNA-dependent RNA polymerase,CHEMBL1138070,Scientific Literature,Inhibition of HCV 1a NS5B RNA polymerase,16650764,Bioorg. Med. Chem. Lett.,2006,16,13,3367,588.61,2.13,213.21,2,Active
CHEMBL387405,Cn1c(c2cocc2)c(C3CCCC3)c4ccc(C(=O)O)c(O)c14,IC50,=,75,nM,7.124938737,Q8JXU8,Hepatitis C virus NS5B RNA-dependent RNA polymerase,CHEMBL1146881,Scientific Literature,Inhibition of HCV 1b NS5B delta21 RNA dependent RNA polymerase by SPA,16908138,Bioorg. Med. Chem. Lett.,2006,16,19,4987,325.36,4.37,75.6,0,Active
CHEMBL216384,OC(=O)c1ccc2c(C3CCCCC3)c4c5ccccc5CCCn4c2c1,IC50,=,77,nM,7.113509275,Q8JXU8,Hepatitis C virus NS5B RNA-dependent RNA polymerase,CHEMBL1137351,Scientific Literature,Inhibition of HCV NS5B RNA polymerase,17125247,J. Med. Chem.,2006,49,24,6950,359.46,6.49,42.23,1,Active
CHEMBL384453,OC(=O)c1ccc2c(C3CCCC3)c(sc2c1)c4cocc4,IC50,=,78,nM,7.107905397,Q8JXU8,Hepatitis C virus NS5B RNA-dependent RNA polymerase,CHEMBL1146881,Scientific Literature,Inhibition of HCV 1b NS5B delta21 RNA dependent RNA polymerase by SPA,16908138,Bioorg. Med. Chem. Lett.,2006,16,19,4987,312.38,4.97,78.67,0,Active
CHEMBL191002,CN(C)C1CNC(C1)C(=O)Cn2c(c3ccccc3)c(C4CCCC4)c5ccc(cc25)C(=O)O,IC50,=,78,nM,7.107905397,Q8JXU8,Hepatitis C virus NS5B RNA-dependent RNA polymerase,CHEMBL1140313,Scientific Literature,Inhibitory activity against by hepatitis C virus NS5B polymerase,15999993,J. Med. Chem.,2005,48,14,4547,459.58,2.04,74.57,0,Active
CHEMBL371635,OC1=C(C(=O)N(CC2CC2)c3ccccc13)C4=NS(=O)(=O)c5ccccc5N4,IC50,=,78,nM,7.107905397,Q8JXU8,Hepatitis C virus NS5B RNA-dependent RNA polymerase,CHEMBL1148625,Scientific Literature,Inhibitory activity against HCV delta 21 NS5B RNA polymerase by SPA assay,16451063,J. Med. Chem.,2006,49,3,971,395.43,1.42,107.44,0,Active
CHEMBL372656,CN(C)Cc1cc(ccc1Cl)c2c(C3CCCCC3)c4ccc(cc4n2CC(=O)N(C)C)C(=O)O,IC50,=,78,nM,7.107905397,Q8JXU8,Hepatitis C virus NS5B RNA-dependent RNA polymerase,CHEMBL1140313,Scientific Literature,Inhibitory activity against by hepatitis C virus NS5B polymerase,15999993,J. Med. Chem.,2005,48,14,4547,496.04,2.93,65.78,0,Active
CHEMBL363342,CC(C)N(C)Cc1cccc(c1)c2c(C3CCCCC3)c4ccc(cc4n2CC(=O)N(C)C)C(=O)O,IC50,=,78,nM,7.107905397,Q8JXU8,Hepatitis C virus NS5B RNA-dependent RNA polymerase,CHEMBL1140313,Scientific Literature,Inhibitory activity against by hepatitis C virus NS5B polymerase,15999993,J. Med. Chem.,2005,48,14,4547,489.65,2.99,65.78,0,Active
CHEMBL381010,CCCCCN1C(=O)C(=C(O)c2ccccc12)C3=NS(=O)(=O)c4ccccc4N3,IC50,=,80,nM,7.096910013,Q8JXU8,Hepatitis C virus NS5B RNA-dependent RNA polymerase,CHEMBL1148625,Scientific Literature,Inhibitory activity against HCV delta 21 NS5B RNA polymerase by SPA assay,16451063,J. Med. Chem.,2006,49,3,971,411.47,2.39,107.44,0,Active
CHEMBL263976,Cn1c(c2ccccc2)c(C3CCCCC3)c4ccc(nc14)C(=O)O,IC50,=,80,nM,7.096910013,Q8JXU8,Hepatitis C virus NS5B RNA-dependent RNA polymerase,CHEMBL1146881,Scientific Literature,Inhibition of HCV 1b NS5B delta21 RNA dependent RNA polymerase by SPA,16908138,Bioorg. Med. Chem. Lett.,2006,16,19,4987,334.41,5.44,55.12,1,Active
CHEMBL210597,OC(=O)[C@@H]1CCCN1S(=O)(=O)c2cc(Cl)c(Cl)c(Cl)c2O,IC50,=,80,nM,7.096910013,Q8JXU8,Hepatitis C virus NS5B RNA-dependent RNA polymerase,CHEMBL1147722,Scientific Literature,Inhibition of HCV NS5B RNA dependent RNA polymerase,16722622,J. Med. Chem.,2006,49,11,3052,374.62,2.78,103.29,0,Active
CHEMBL192896,OC(=O)\C(=C\c1ccc(Oc2ccccc2Br)cc1)\NC(=O)c3ccccc3O,IC50,=,80,nM,7.096910013,Q8JXU8,Hepatitis C virus NS5B RNA-dependent RNA polymerase,CHEMBL1145278,Scientific Literature,Inhibitory concentration against RNA dependent RNA polymerase Nonstructural protein 5B (HCV NS5B polymerase) in Hepatitis C virus,15911260,Bioorg. Med. Chem. Lett.,2005,15,11,2812,454.27,4.48,95.86,0,Active
CHEMBL384144,OC(=O)c1ccc2c(C3CCCC3)c(oc2c1)c4cocc4,IC50,=,81,nM,7.091514981,Q8JXU8,Hepatitis C virus NS5B RNA-dependent RNA polymerase,CHEMBL1146881,Scientific Literature,Inhibition of HCV 1b NS5B delta21 RNA dependent RNA polymerase by SPA,16908138,Bioorg. Med. Chem. Lett.,2006,16,19,4987,296.32,4.41,63.58,0,Active
CHEMBL201063,OC1=C(C2=NS(=O)(=O)c3ccccc3N2)C(=O)N(Cc4cccc(c4)[N+](=O)[O-])c5ccccc15,IC50,=,81,nM,7.091514981,Q8JXU8,Hepatitis C virus NS5B RNA-dependent RNA polymerase,CHEMBL1148625,Scientific Literature,Inhibitory activity against HCV delta 21 NS5B RNA polymerase by SPA assay,16451063,J. Med. Chem.,2006,49,3,971,476.46,2.08,153.26,0,Active
CHEMBL201436,COC(C)CCN1C(=O)C(=C(O)c2ccccc12)C3=NS(=O)(=O)c4ccccc4N3,IC50,=,82,nM,7.086186148,Q8JXU8,Hepatitis C virus NS5B RNA-dependent RNA polymerase,CHEMBL1148625,Scientific Literature,Inhibitory activity against HCV delta 21 NS5B RNA polymerase by SPA assay,16451063,J. Med. Chem.,2006,49,3,971,427.47,0.91,116.68,0,Active
CHEMBL201088,OC1=C(C2=NS(=O)(=O)c3ccccc3N2)C(=O)N(Cc4ccccc4)c5ccccc15,IC50,=,82,nM,7.086186148,Q8JXU8,Hepatitis C virus NS5B RNA-dependent RNA polymerase,CHEMBL1148625,Scientific Literature,Inhibitory activity against HCV delta 21 NS5B RNA polymerase by SPA assay,16451063,J. Med. Chem.,2006,49,3,971,431.46,2.18,107.44,0,Active
CHEMBL208822,COCCOC(=O)NS(=O)(=O)Nc1ccc2N=C(NS(=O)(=O)c2c1)C3=C(O)c4cccnc4N(CCC(C)C)C3=O,IC50,=,87,nM,7.060480747,Q8JXU8,Hepatitis C virus NS5B RNA-dependent RNA polymerase,CHEMBL1138070,Scientific Literature,Inhibition of HCV 1a NS5B RNA polymerase,16650764,Bioorg. Med. Chem. Lett.,2006,16,13,3367,608.64,0.81,222.44,2,Active
CHEMBL210491,CC(C)CCN1C(=O)C(=C(O)c2cccnc12)C3=NS(=O)(=O)c4cc(NS(=O)(=O)NC(=O)OCC=C)ccc4N3,IC50,=,88,nM,7.055517328,Q8JXU8,Hepatitis C virus NS5B RNA-dependent RNA polymerase,CHEMBL1138070,Scientific Literature,Inhibition of HCV 1a NS5B RNA polymerase,16650764,Bioorg. Med. Chem. Lett.,2006,16,13,3367,590.63,1.56,213.21,2,Active
CHEMBL205579,CCC(C)[C@@H]1N(Cc2ccccc2)C(=O)C(=C1O)C3=NS(=O)(=O)c4ccccc4N3,IC50,=,88,nM,7.055517328,Q8JXU8,Hepatitis C virus NS5B RNA-dependent RNA polymerase,CHEMBL1146957,Scientific Literature,Inhibition of HCV NS5B RNA dependent RNA polymerase,16455253,Bioorg. Med. Chem. Lett.,2006,16,8,2205,425.5,3,107.45,0,Active
CHEMBL209396,Cc1nc(c(COc2ccc(cc2)c3nc4cc(ccc4n3C5CCCCC5)C(=O)O)s1)c6ccc(Cl)cc6,IC50,=,90,nM,7.045757491,Q8JXU8,Hepatitis C virus NS5B RNA-dependent RNA polymerase,CHEMBL1138950,Scientific Literature,Inhibition of HCV 1b BK six His-tagged C-terminal truncated 544 amino acid NS5B RNA dependent RNA polymerase,16854079,J. Med. Chem.,2006,49,15,4721,558.09,7.94,105.48,2,Active
CHEMBL192804,OC(=O)\C(=C\c1ccc(Oc2ccccc2Br)cc1)\NC(=O)c3cccc(F)c3,IC50,=,90,nM,7.045757491,Q8JXU8,Hepatitis C virus NS5B RNA-dependent RNA polymerase,CHEMBL1145278,Scientific Literature,Inhibitory concentration against RNA dependent RNA polymerase Nonstructural protein 5B (HCV NS5B polymerase) in Hepatitis C virus,15911260,Bioorg. Med. Chem. Lett.,2005,15,11,2812,456.26,4.93,75.63,0,Active
CHEMBL201814,OC1=C(C(=O)N(CCC=C)c2ccccc12)C3=NS(=O)(=O)c4ccccc4N3,IC50,=,90,nM,7.045757491,Q8JXU8,Hepatitis C virus NS5B RNA-dependent RNA polymerase,CHEMBL1148625,Scientific Literature,Inhibitory activity against HCV delta 21 NS5B RNA polymerase by SPA assay,16451063,J. Med. Chem.,2006,49,3,971,395.43,1.54,107.44,0,Active
CHEMBL206793,Cc1cccc(Cl)c1CNC(=O)Nc2ccsc2c3nc(O)c(O)c(n3)C(=O)O,IC50,=,90,nM,7.045757491,Q8JXU8,Hepatitis C virus NS5B RNA-dependent RNA polymerase,CHEMBL1138187,Scientific Literature,Inhibitory activity against HCV 1b BK NS5B deltaC55 RNA polymerase,16509585,J. Med. Chem.,2006,49,5,1693,434.85,3.59,172.91,0,Active
CHEMBL215233,Cn1c(c2ccccn2)c(C3CCCCC3)c4ccc(cc14)C(=O)O,IC50,=,90,nM,7.045757491,Q8JXU8,Hepatitis C virus NS5B RNA-dependent RNA polymerase,CHEMBL1146881,Scientific Literature,Inhibition of HCV 1b NS5B delta21 RNA dependent RNA polymerase by SPA,16908138,Bioorg. Med. Chem. Lett.,2006,16,19,4987,334.41,5.24,55.12,1,Active
CHEMBL175002,Nc1ccc2[nH]cc(C[C@H](NC(=O)c3ccc4c(c3)nc(c5cocc5)n4C6CCCCC6)C(=O)O)c2c1,IC50,=,90,nM,7.045757491,Q8JXU8,Hepatitis C virus NS5B RNA-dependent RNA polymerase,CHEMBL1149207,Scientific Literature,Concentration required for inhibiting hepatitis C virus NS5B RNA polymerase activity.,15013003,Bioorg. Med. Chem. Lett.,2004,14,4,967,511.57,4.72,139.16,1,Active
CHEMBL383170,OC1=C(C(=O)N(CCC2CC2)c3c(F)cccc13)C4=NS(=O)(=O)c5ccccc5N4,IC50,=,90,nM,7.045757491,Q8JXU8,Hepatitis C virus NS5B RNA-dependent RNA polymerase,CHEMBL1148625,Scientific Literature,Inhibitory activity against HCV delta 21 NS5B RNA polymerase by SPA assay,16451063,J. Med. Chem.,2006,49,3,971,427.45,2.02,107.44,0,Active
CHEMBL369555,OC1=C(C(=O)N(CC2CCCCC2)c3ncccc13)C4=NS(=O)(=O)c5ccccc5N4,IC50,=,93,nM,7.031517051,Q8JXU8,Hepatitis C virus NS5B RNA-dependent RNA polymerase,CHEMBL1142034,Scientific Literature,Inhibitory concentration against RNA dependent RNA polymerase Nonstructural protein 5B of genotype 1b Hepatitis C virus,15745800,Bioorg. Med. Chem. Lett.,2005,15,6,1577,438.5,2.18,120.34,0,Active
CHEMBL211766,OC(=O)c1ccc2c(C3CCCCC3)c(cn2c1)c4ccccc4,IC50,=,94,nM,7.026872146,Q8JXU8,Hepatitis C virus NS5B RNA-dependent RNA polymerase,CHEMBL1146030,Scientific Literature,Inhibition of HCV BK NS5B deltaC55 RNA dependent RNA polymerase,16714108,Bioorg. Med. Chem. Lett.,2006,16,15,4026,319.4,4.86,41.71,0,Active
CHEMBL201660,OC1=C(C2=NS(=O)(=O)c3ccccc3N2)C(=O)N(Cc4ccc(Br)cc4)c5ccccc15,IC50,=,95,nM,7.022276395,Q8JXU8,Hepatitis C virus NS5B RNA-dependent RNA polymerase,CHEMBL1148625,Scientific Literature,Inhibitory activity against HCV delta 21 NS5B RNA polymerase by SPA assay,16451063,J. Med. Chem.,2006,49,3,971,510.36,2.93,107.44,1,Active
CHEMBL379718,CC(C)CCN1C(=O)C(=C(O)c2cccnc12)C3=NS(=O)(=O)c4cc(NS(=O)(=O)NC(=O)OCCOCc5ccccc5)ccc4N3,IC50,=,96,nM,7.017728767,Q8JXU8,Hepatitis C virus NS5B RNA-dependent RNA polymerase,CHEMBL1138070,Scientific Literature,Inhibition of HCV 1a NS5B RNA polymerase,16650764,Bioorg. Med. Chem. Lett.,2006,16,13,3367,684.74,2.39,222.44,2,Active
CHEMBL365793,CN(C)C(=O)CN(C)C(=O)Cn1c(c2ccccc2)c(C3CCCCC3)c4ccc(cc14)C(=O)O,IC50,=,98,nM,7.008773924,Q8JXU8,Hepatitis C virus NS5B RNA-dependent RNA polymerase,CHEMBL1140313,Scientific Literature,Inhibitory activity against by hepatitis C virus NS5B polymerase,15999993,J. Med. Chem.,2005,48,14,4547,475.58,4.49,82.85,0,Active
CHEMBL378546,Cc1ccc(cc1)c2ccc(Cl)cc2COc3ccc(cc3)c4nc5cc(ccc5n4C6CCCCC6)C(=O)O,IC50,=,98,nM,7.008773924,Q8JXU8,Hepatitis C virus NS5B RNA-dependent RNA polymerase,CHEMBL1138950,Scientific Literature,Inhibition of HCV 1b BK six His-tagged C-terminal truncated 544 amino acid NS5B RNA dependent RNA polymerase,16854079,J. Med. Chem.,2006,49,15,4721,551.07,9.2,64.35,2,Active
CHEMBL387301,OC(=O)c1ccc2c(c1)nc(c3ccc(OCc4ccccc4c5ccccc5)cc3F)n2C6CCCCC6,IC50,=,100,nM,7,Q8JXU8,Hepatitis C virus NS5B RNA-dependent RNA polymerase,CHEMBL1138950,Scientific Literature,Inhibition of HCV 1b BK six His-tagged C-terminal truncated 544 amino acid NS5B RNA dependent RNA polymerase,16854079,J. Med. Chem.,2006,49,15,4721,520.59,8.26,64.35,2,Active
CHEMBL362185,OC(=O)C(=O)\C=C(/O)\c1cccc(OCc2cc(Br)ccc2C#N)c1,IC50,=,100,nM,7,Q8JXU8,Hepatitis C virus NS5B RNA-dependent RNA polymerase,CHEMBL1140440,Scientific Literature,"Inhibitory concentration against NS5B HCV polymerase using [alpha-32P]UTP as radioligand (30 degree C for 2 h, at pH 7.5 with Tris-HCl buffer)",16190757,J. Med. Chem.,2005,48,20,6304,402.2,3.46,107.62,0,Active
CHEMBL198423,OC(=O)C(=O)\C=C(/O)\c1cc(O)cc(OCc2c(Cl)cccc2C#N)c1,IC50,=,100,nM,7,Q8JXU8,Hepatitis C virus NS5B RNA-dependent RNA polymerase,CHEMBL1140440,Scientific Literature,"Inhibitory concentration against NS5B HCV polymerase using [alpha-32P]UTP as radioligand (30 degree C for 2 h, at pH 7.5 with Tris-HCl buffer)",16190757,J. Med. Chem.,2005,48,20,6304,373.74,3.13,127.85,0,Active
CHEMBL192358,OC(=O)\C(=C\c1ccc(Oc2ccccc2Br)cc1)\NC(=O)C3CC4CCC3C4,IC50,=,100,nM,7,Q8JXU8,Hepatitis C virus NS5B RNA-dependent RNA polymerase,CHEMBL1145278,Scientific Literature,Inhibitory concentration against RNA dependent RNA polymerase Nonstructural protein 5B (HCV NS5B polymerase) in Hepatitis C virus,15911260,Bioorg. Med. Chem. Lett.,2005,15,11,2812,456.33,4.86,75.63,0,Active
CHEMBL211649,COc1ccc(cc1)c2ccc(Cl)cc2COc3ccc(cc3)c4nc5cc(ccc5n4C6CCCCC6)C(=O)O,IC50,=,100,nM,7,Q8JXU8,Hepatitis C virus NS5B RNA-dependent RNA polymerase,CHEMBL1138950,Scientific Literature,Inhibition of HCV 1b BK six His-tagged C-terminal truncated 544 amino acid NS5B RNA dependent RNA polymerase,16854079,J. Med. Chem.,2006,49,15,4721,567.07,8.7,73.58,2,Active
CHEMBL381101,FC(F)(F)c1ccc(Cl)c(c1)c2oc(\C=C\3/SC(=S)N(NS(=O)(=O)c4ccccc4)C3=O)cc2,IC50,=,100,nM,7,Q8JXU8,Hepatitis C virus NS5B RNA-dependent RNA polymerase,CHEMBL1149391,Scientific Literature,Inhibitory activity against HCV delta 21 NS5b RNA polymerase,16451069,J. Med. Chem.,2006,49,3,1034,544.97,6.4,145.38,2,Active
CHEMBL369000,CC(C)(Oc1ccc2[nH]cc(C[C@H](NC(=O)c3ccc4c(c3)nc(c5cocc5)n4C6CCCCC6)C(=O)O)c2c1)C(=O)O,IC50,=,100,nM,7,Q8JXU8,Hepatitis C virus NS5B RNA-dependent RNA polymerase,CHEMBL1149207,Scientific Literature,Concentration required for inhibiting hepatitis C virus NS5B RNA polymerase activity.,15013003,Bioorg. Med. Chem. Lett.,2004,14,4,967,598.65,5.72,159.67,2,Active
CHEMBL188442,OC(=O)\C(=C\c1ccc(Oc2ccccc2Br)cc1)\NC(=O)c3ccccc3,IC50,=,100,nM,7,Q8JXU8,Hepatitis C virus NS5B RNA-dependent RNA polymerase,CHEMBL1145278,Scientific Literature,Inhibitory concentration against RNA dependent RNA polymerase Nonstructural protein 5B (HCV NS5B polymerase) in Hepatitis C virus,15911260,Bioorg. Med. Chem. Lett.,2005,15,11,2812,438.27,4.73,75.63,0,Active
CHEMBL381529,CC(C)CCN1C(=O)C(=C(O)c2c(Br)cccc12)C3=NS(=O)(=O)c4ccccc4N3,IC50,=,105,nM,6.978810701,Q8JXU8,Hepatitis C virus NS5B RNA-dependent RNA polymerase,CHEMBL1148625,Scientific Literature,Inhibitory activity against HCV delta 21 NS5B RNA polymerase by SPA assay,16451063,J. Med. Chem.,2006,49,3,971,490.37,2.93,107.44,0,Active
CHEMBL202164,OC1=C(C(=O)N(CCCC(F)(F)F)c2ccccc12)C3=NS(=O)(=O)c4ccccc4N3,IC50,=,106,nM,6.974694135,Q8JXU8,Hepatitis C virus NS5B RNA-dependent RNA polymerase,CHEMBL1148625,Scientific Literature,Inhibitory activity against HCV delta 21 NS5B RNA polymerase by SPA assay,16451063,J. Med. Chem.,2006,49,3,971,451.42,2.19,107.44,0,Active
CHEMBL212223,CC(C)CCN1C(=O)C(=C(O)c2cccnc12)C3=NS(=O)(=O)c4cc(NS(=O)(=O)NCCO)ccc4N3,IC50,=,107,nM,6.970616222,Q8JXU8,Hepatitis C virus NS5B RNA-dependent RNA polymerase,CHEMBL1138070,Scientific Literature,Inhibition of HCV 1a NS5B RNA polymerase,16650764,Bioorg. Med. Chem. Lett.,2006,16,13,3367,550.61,-0.03,207.14,1,Active
CHEMBL382628,CC(C)CN1C(=O)C(=C(O)c2ccccc12)C3=NS(=O)(=O)c4ccccc4N3,IC50,=,108,nM,6.966576245,Q8JXU8,Hepatitis C virus NS5B RNA-dependent RNA polymerase,CHEMBL1148625,Scientific Literature,Inhibitory activity against HCV delta 21 NS5B RNA polymerase by SPA assay,16451063,J. Med. Chem.,2006,49,3,971,397.45,1.79,107.44,0,Active
CHEMBL196447,OC(=O)C(=O)\C=C(/O)\c1cc(O)ccc1OCCCC#N,IC50,=,110,nM,6.958607315,Q8JXU8,Hepatitis C virus NS5B RNA-dependent RNA polymerase,CHEMBL1140440,Scientific Literature,"Inhibitory concentration against NS5B HCV polymerase using [alpha-32P]UTP as radioligand (30 degree C for 2 h, at pH 7.5 with Tris-HCl buffer)",16190757,J. Med. Chem.,2005,48,20,6304,291.26,1.31,127.85,0,Active
CHEMBL190800,OC(=O)\C(=C\c1ccc(Oc2ccccc2Br)cc1)\NC(=O)c3ccc(Cl)cc3,IC50,=,110,nM,6.958607315,Q8JXU8,Hepatitis C virus NS5B RNA-dependent RNA polymerase,CHEMBL1145278,Scientific Literature,Inhibitory concentration against RNA dependent RNA polymerase Nonstructural protein 5B (HCV NS5B polymerase) in Hepatitis C virus,15911260,Bioorg. Med. Chem. Lett.,2005,15,11,2812,472.72,5.39,75.63,1,Active
CHEMBL366823,OC(=O)C(=O)\C=C(/O)\c1cccc(OCc2cccc(Cl)c2C#N)c1,IC50,=,110,nM,6.958607315,Q8JXU8,Hepatitis C virus NS5B RNA-dependent RNA polymerase,CHEMBL1139456,Scientific Literature,Inhibitory activity against Hepatitis C virus RNA dependent RNA polymerase nonstructural protein 5B,14695815,J. Med. Chem.,2004,47,1,14,357.74,3.38,107.62,0,Active
CHEMBL368647,OC(=O)c1ccc2c(C3CCCCC3)c(c4ccccc4)n(CCN5CCOCC5)c2c1,IC50,=,111,nM,6.954677021,Q8JXU8,Hepatitis C virus NS5B RNA-dependent RNA polymerase,CHEMBL1142688,Scientific Literature,Inhibitory activity against RNA dependent RNA polymerase nonstructural protein 5B in hepatitis C virus; n=1,15743173,J. Med. Chem.,2005,48,5,1314,432.55,2.75,54.7,0,Active
CHEMBL202310,CCOC(=O)CNc1ccc2N(CCC(C)C)C(=O)C(=C(O)c2c1)C3=NS(=O)(=O)c4ccccc4N3,IC50,=,115,nM,6.93930216,Q8JXU8,Hepatitis C virus NS5B RNA-dependent RNA polymerase,CHEMBL1148625,Scientific Literature,Inhibitory activity against HCV delta 21 NS5B RNA polymerase by SPA assay,16451063,J. Med. Chem.,2006,49,3,971,512.58,2.05,145.77,1,Active
CHEMBL382997,CC(C)CCN1C(=O)C(=C(O)c2cccnc12)C3=NS(=O)(=O)c4cc(NS(=O)(=O)Nc5cccc(c5)C(=O)O)ccc4N3,IC50,=,115,nM,6.93930216,Q8JXU8,Hepatitis C virus NS5B RNA-dependent RNA polymerase,CHEMBL1138070,Scientific Literature,Inhibition of HCV 1a NS5B RNA polymerase,16650764,Bioorg. Med. Chem. Lett.,2006,16,13,3367,626.66,1.07,224.21,2,Active
CHEMBL202271,OC1=C(C(=O)N(CCC#C)c2ccccc12)C3=NS(=O)(=O)c4ccccc4N3,IC50,=,118,nM,6.928117993,Q8JXU8,Hepatitis C virus NS5B RNA-dependent RNA polymerase,CHEMBL1148625,Scientific Literature,Inhibitory activity against HCV delta 21 NS5B RNA polymerase by SPA assay,16451063,J. Med. Chem.,2006,49,3,971,393.42,2.11,107.44,0,Active
CHEMBL177073,CS(=O)(=O)Nc1ccc2[nH]cc(C[C@H](NC(=O)c3ccc4c(c3)nc(c5cocc5)n4C6CCCCC6)C(=O)O)c2c1,IC50,=,120,nM,6.920818754,Q8JXU8,Hepatitis C virus NS5B RNA-dependent RNA polymerase,CHEMBL1149207,Scientific Literature,Concentration required for inhibiting hepatitis C virus NS5B RNA polymerase activity.,15013003,Bioorg. Med. Chem. Lett.,2004,14,4,967,589.66,4.37,167.7,1,Active
CHEMBL184072,COc1ccc2c(C(=O)NC(CCC(=O)O)C(=O)O)c(Br)ccc2c1C(F)(F)F,IC50,=,120,nM,6.920818754,Q8JXU8,Hepatitis C virus NS5B RNA-dependent RNA polymerase,CHEMBL1137155,Scientific Literature,Inhibitory concentration against HCV NS5B RNA dependent RNA polymerase,15261274,Bioorg. Med. Chem. Lett.,2004,14,16,4221,478.21,3.29,112.93,0,Active
CHEMBL365105,OC(=O)\C(=C\c1ccc(Oc2ccccc2Br)cc1)\NC(=O)c3ccc(Br)cc3,IC50,=,120,nM,6.920818754,Q8JXU8,Hepatitis C virus NS5B RNA-dependent RNA polymerase,CHEMBL1145278,Scientific Literature,Inhibitory concentration against RNA dependent RNA polymerase Nonstructural protein 5B (HCV NS5B polymerase) in Hepatitis C virus,15911260,Bioorg. Med. Chem. Lett.,2005,15,11,2812,517.17,5.47,75.63,2,Active
CHEMBL448112,OC(=O)c1cc2c(C3CCCCC3)c([nH]c2s1)c4ccccc4,IC50,=,120,nM,6.920818754,Q8JXU8,Hepatitis C virus NS5B RNA-dependent RNA polymerase,CHEMBL1146030,Scientific Literature,Inhibition of HCV BK NS5B deltaC55 RNA dependent RNA polymerase,16714108,Bioorg. Med. Chem. Lett.,2006,16,15,4026,325.42,5.59,81.33,1,Active
CHEMBL217213,Cn1c(c2ccc(OCc3ccccc3)cc2)c(C4CCCCC4)c5ccc(cc15)C(=O)O,IC50,=,120,nM,6.920818754,Q8JXU8,Hepatitis C virus NS5B RNA-dependent RNA polymerase,CHEMBL1137351,Scientific Literature,Inhibition of HCV NS5B RNA polymerase,17125247,J. Med. Chem.,2006,49,24,6950,439.55,7.53,51.46,1,Active
CHEMBL217670,CC(=O)N1CCn2c(c3ccccc13)c(C4CCCCC4)c5ccc(cc25)C(=O)O,IC50,=,120,nM,6.920818754,Q8JXU8,Hepatitis C virus NS5B RNA-dependent RNA polymerase,CHEMBL1137351,Scientific Literature,Inhibition of HCV NS5B RNA polymerase,17125247,J. Med. Chem.,2006,49,24,6950,402.49,5.11,62.54,1,Active
CHEMBL209006,CC(C)CCN1C(=O)C(=C(O)c2cccnc12)C3=NS(=O)(=O)c4cc(NS(=O)(=O)N(C)C(=O)OCc5ccccc5)ccc4N3,IC50,=,121,nM,6.91721463,Q8JXU8,Hepatitis C virus NS5B RNA-dependent RNA polymerase,CHEMBL1138070,Scientific Literature,Inhibition of HCV 1a NS5B RNA polymerase,16650764,Bioorg. Med. Chem. Lett.,2006,16,13,3367,654.71,2.08,204.42,2,Active
CHEMBL239863,COC(=O)c1ccccc1NS(=O)(=O)Nc2ccc3NC(=NS(=O)(=O)c3c2)C4=C(O)c5cccnc5N(CCC(C)C)C4=O,IC50,=,129,nM,6.88941029,Q8JXU8,Hepatitis C virus NS5B RNA-dependent RNA polymerase,CHEMBL1138070,Scientific Literature,Inhibition of HCV 1a NS5B RNA polymerase,16650764,Bioorg. Med. Chem. Lett.,2006,16,13,3367,640.69,1.94,213.21,2,Active
CHEMBL216044,COc1ccc(CCC2(CC(=O)C(=C(O)O2)Sc3ccc(O)cc3)C4CCCC4)cc1Cl,IC50,=,130,nM,6.886056648,Q8JXU8,Hepatitis C virus NS5B RNA-dependent RNA polymerase,CHEMBL1149470,Scientific Literature,Inhibitory activity against HCV 1b BK NS5B deltaC21 RNA polymerase,16824756,Bioorg. Med. Chem. Lett.,2006,16,18,4834,475,6.55,101.29,1,Active
CHEMBL418899,C[C@@]1(O)[C@H](O)[C@@H](CO)O[C@H]1n2cnc3C(=O)NC(=Nc23)N,IC50,=,130,nM,6.886056648,Q8JXU8,Hepatitis C virus NS5B RNA-dependent RNA polymerase,CHEMBL1149159,Scientific Literature,Inhibition HCV NS5B-mediated RNA synthesis,15084127,J. Med. Chem.,2004,47,9,2283,297.27,-2.18,155.22,0,Active
CHEMBL200405,CCCC1(CC(=O)O)OCCc2c1sc3c(C)cc(F)c(C#N)c23,IC50,=,130,nM,6.886056648,Q8JXU8,Hepatitis C virus NS5B RNA-dependent RNA polymerase,CHEMBL1148590,Scientific Literature,Displacement of [alpha-32P]GTP from recombinant HCV NS5B RNA dependent RNA polymerase,16274990,Bioorg. Med. Chem. Lett.,2006,16,2,457,347.4,4.38,98.56,0,Active
CHEMBL380442,OC1=C(C(=O)N(CC2CCCC2)c3ccccc13)C4=NS(=O)(=O)c5ccccc5N4,IC50,=,132,nM,6.879426069,Q8JXU8,Hepatitis C virus NS5B RNA-dependent RNA polymerase,CHEMBL1148625,Scientific Literature,Inhibitory activity against HCV delta 21 NS5B RNA polymerase by SPA assay,16451063,J. Med. Chem.,2006,49,3,971,423.48,2.33,107.44,0,Active
CHEMBL396311,CCOC(=O)c1cccc(NS(=O)(=O)Nc2ccc3NC(=NS(=O)(=O)c3c2)C4=C(O)c5cccnc5N(CCC(C)C)C4=O)c1,IC50,=,132,nM,6.879426069,Q8JXU8,Hepatitis C virus NS5B RNA-dependent RNA polymerase,CHEMBL1138070,Scientific Literature,Inhibition of HCV 1a NS5B RNA polymerase,16650764,Bioorg. Med. Chem. Lett.,2006,16,13,3367,654.71,2.29,213.21,2,Active
CHEMBL370542,CN(C)C(=O)Cn1c(c2ccncc2)c(C3CCCCC3)c4ccc(cc14)C(=O)O,IC50,=,134,nM,6.872895202,Q8JXU8,Hepatitis C virus NS5B RNA-dependent RNA polymerase,CHEMBL1140313,Scientific Literature,Inhibitory activity against by hepatitis C virus NS5B polymerase,15999993,J. Med. Chem.,2005,48,14,4547,405.49,4.08,75.43,0,Active
CHEMBL217580,COc1ccc(CCC2(CC(=O)C(=C(O)O2)Sc3nccn3C)C4CCCC4)cc1Cl,IC50,=,140,nM,6.853871964,Q8JXU8,Hepatitis C virus NS5B RNA-dependent RNA polymerase,CHEMBL1149470,Scientific Literature,Inhibitory activity against HCV 1b BK NS5B deltaC21 RNA polymerase,16824756,Bioorg. Med. Chem. Lett.,2006,16,18,4834,462.99,5.43,98.88,1,Active
CHEMBL367430,OC(=O)[C@H](Cc1c[nH]c2ccc(O)cc12)NC(=O)c3ccc4c(c3)nc(c5ccccn5)n4C6CCCCC6,IC50,=,140,nM,6.853871964,Q8JXU8,Hepatitis C virus NS5B RNA-dependent RNA polymerase,CHEMBL1149207,Scientific Literature,Concentration required for inhibiting hepatitis C virus NS5B RNA polymerase activity.,15013003,Bioorg. Med. Chem. Lett.,2004,14,4,967,523.58,5.39,133.13,2,Active
CHEMBL425286,OC(=O)c1ccc2c(C3CCCCC3)c4c5ccccc5OCn4c2c1,IC50,=,140,nM,6.853871964,Q8JXU8,Hepatitis C virus NS5B RNA-dependent RNA polymerase,CHEMBL1137351,Scientific Literature,Inhibition of HCV NS5B RNA polymerase,17125247,J. Med. Chem.,2006,49,24,6950,347.41,5.74,51.45,1,Active
CHEMBL198349,CCCC1(CC(=O)O)OCCc2c1sc3c(Cl)ccc(Cl)c23,IC50,=,140,nM,6.853871964,Q8JXU8,Hepatitis C virus NS5B RNA-dependent RNA polymerase,CHEMBL1148590,Scientific Literature,Displacement of [alpha-32P]GTP from recombinant HCV NS5B RNA dependent RNA polymerase,16274990,Bioorg. Med. Chem. Lett.,2006,16,2,457,359.27,5.13,74.77,1,Active
CHEMBL377504,OC(=O)c1nc(nc(O)c1O)c2sccc2NC(=O)OCc3cccc4ccccc34,IC50,=,140,nM,6.853871964,Q8JXU8,Hepatitis C virus NS5B RNA-dependent RNA polymerase,CHEMBL1138187,Scientific Literature,Inhibitory activity against HCV 1b BK NS5B deltaC55 RNA polymerase,16509585,J. Med. Chem.,2006,49,5,1693,437.43,3.99,170.11,0,Active
CHEMBL385206,OC(=O)c1ccc2c(C3CCCCC3)c4c5ccccc5CCn4c2c1,IC50,=,140,nM,6.853871964,Q8JXU8,Hepatitis C virus NS5B RNA-dependent RNA polymerase,CHEMBL1137351,Scientific Literature,Inhibition of HCV NS5B RNA polymerase,17125247,J. Med. Chem.,2006,49,24,6950,345.43,6.03,42.23,1,Active
CHEMBL198813,OC(=O)C(=O)\C=C(/O)\c1cccc(NS(=O)(=O)c2cc(Cl)cc(Cl)c2)c1,IC50,=,140,nM,6.853871964,Q8JXU8,Hepatitis C virus NS5B RNA-dependent RNA polymerase,CHEMBL1140440,Scientific Literature,"Inhibitory concentration against NS5B HCV polymerase using [alpha-32P]UTP as radioligand (30 degree C for 2 h, at pH 7.5 with Tris-HCl buffer)",16190757,J. Med. Chem.,2005,48,20,6304,416.23,3.08,129.15,0,Active
CHEMBL201604,CC(C)CCN1C(=O)C(=C(O)c2c1cccc2c3ccccc3)C4=NS(=O)(=O)c5ccccc5N4,IC50,=,144,nM,6.841637508,Q8JXU8,Hepatitis C virus NS5B RNA-dependent RNA polymerase,CHEMBL1148625,Scientific Literature,Inhibitory activity against HCV delta 21 NS5B RNA polymerase by SPA assay,16451063,J. Med. Chem.,2006,49,3,971,487.57,4.35,107.44,0,Active
CHEMBL205648,CC(C)CCN1[C@@H](C(C)C)C(=C(C1=O)C2=NS(=O)(=O)c3ccccc3N2)O,IC50,=,147,nM,6.832682665,Q8JXU8,Hepatitis C virus NS5B RNA-dependent RNA polymerase,CHEMBL1146957,Scientific Literature,Inhibition of HCV NS5B RNA dependent RNA polymerase,16455253,Bioorg. Med. Chem. Lett.,2006,16,8,2205,391.48,1.89,107.45,0,Active
CHEMBL189725,CN(C)Cc1cccc(c1)c2c(C3CCCCC3)c4ccc(cc4n2CC(=O)N(C)C)C(=O)O,IC50,=,147,nM,6.832682665,Q8JXU8,Hepatitis C virus NS5B RNA-dependent RNA polymerase,CHEMBL1140313,Scientific Literature,Inhibitory activity against by hepatitis C virus NS5B polymerase,15999993,J. Med. Chem.,2005,48,14,4547,461.6,2.26,65.78,0,Active
CHEMBL1789968,Cc1c(c2cocc2)n(C3CCCC3)c4cc(ccc14)C(=O)O,IC50,=,150,nM,6.823908741,Q8JXU8,Hepatitis C virus NS5B RNA-dependent RNA polymerase,CHEMBL1146881,Scientific Literature,Inhibition of HCV 1b NS5B delta21 RNA dependent RNA polymerase by SPA,16908138,Bioorg. Med. Chem. Lett.,2006,16,19,4987,309.36,4.76,55.37,0,Active
CHEMBL209796,OC(=O)c1ccc2c(C3CCCCC3)c([nH]c2n1)c4ccccc4,IC50,=,150,nM,6.823908741,Q8JXU8,Hepatitis C virus NS5B RNA-dependent RNA polymerase,CHEMBL1146030,Scientific Literature,Inhibition of HCV BK NS5B deltaC55 RNA dependent RNA polymerase,16714108,Bioorg. Med. Chem. Lett.,2006,16,15,4026,320.39,5.23,65.97,1,Active
CHEMBL201341,C\C=C\CN1C(=O)C(=C(O)c2ccccc12)C3=NS(=O)(=O)c4ccccc4N3,IC50,=,150,nM,6.823908741,Q8JXU8,Hepatitis C virus NS5B RNA-dependent RNA polymerase,CHEMBL1148625,Scientific Literature,Inhibitory activity against HCV delta 21 NS5B RNA polymerase by SPA assay,16451063,J. Med. Chem.,2006,49,3,971,395.43,1.62,107.44,0,Active
CHEMBL378524,OC(=O)c1ccc2c(c1)nc(c3ccc(OCc4ncccc4c5ccc(Cl)cc5)cc3)n2C6CCCCC6,IC50,=,150,nM,6.823908741,Q8JXU8,Hepatitis C virus NS5B RNA-dependent RNA polymerase,CHEMBL1138950,Scientific Literature,Inhibition of HCV 1b BK six His-tagged C-terminal truncated 544 amino acid NS5B RNA dependent RNA polymerase,16854079,J. Med. Chem.,2006,49,15,4721,538.04,7.78,77.24,2,Active
CHEMBL368852,OC(=O)[C@H](Cc1c[nH]c2ccc(NS(=O)(=O)C(F)(F)F)cc12)NC(=O)c3ccc4c(c3)nc(c5cocc5)n4C6CCCCC6,IC50,=,150,nM,6.823908741,Q8JXU8,Hepatitis C virus NS5B RNA-dependent RNA polymerase,CHEMBL1149207,Scientific Literature,Concentration required for inhibiting hepatitis C virus NS5B RNA polymerase activity.,15013003,Bioorg. Med. Chem. Lett.,2004,14,4,967,643.63,6.51,167.7,2,Active
CHEMBL176924,Cn1cc(C[C@@H](NC(=O)c2ccc3c(c2)nc(c4cocc4)n3C5CCCCC5)C(=O)O)c6cc(O)ccc16,IC50,=,160,nM,6.795880017,Q8JXU8,Hepatitis C virus NS5B RNA-dependent RNA polymerase,CHEMBL1149207,Scientific Literature,Concentration required for inhibiting hepatitis C virus NS5B RNA polymerase activity.,15013003,Bioorg. Med. Chem. Lett.,2004,14,4,967,526.58,5.43,122.52,2,Active
CHEMBL212583,Cc1nc(COc2ccc(cc2)c3nc4cc(ccc4n3C5CCCCC5)C(=O)O)c(s1)c6ccc(Cl)cc6,IC50,=,170,nM,6.769551079,Q8JXU8,Hepatitis C virus NS5B RNA-dependent RNA polymerase,CHEMBL1138950,Scientific Literature,Inhibition of HCV 1b BK six His-tagged C-terminal truncated 544 amino acid NS5B RNA dependent RNA polymerase,16854079,J. Med. Chem.,2006,49,15,4721,558.09,7.94,105.48,2,Active
CHEMBL199954,CCC[C@]1(CC(=O)O)OCCc2c1sc3c(C)ccc(C#N)c23,IC50,=,170,nM,6.769551079,Q8JXU8,Hepatitis C virus NS5B RNA-dependent RNA polymerase,CHEMBL1148590,Scientific Literature,Displacement of [alpha-32P]GTP from recombinant HCV NS5B RNA dependent RNA polymerase,16274990,Bioorg. Med. Chem. Lett.,2006,16,2,457,329.41,4.17,98.56,0,Active
CHEMBL201567,OC1=C(C(=O)N(CCCC#N)c2ccccc12)C3=NS(=O)(=O)c4ccccc4N3,IC50,=,172,nM,6.764471553,Q8JXU8,Hepatitis C virus NS5B RNA-dependent RNA polymerase,CHEMBL1148625,Scientific Literature,Inhibitory activity against HCV delta 21 NS5B RNA polymerase by SPA assay,16451063,J. Med. Chem.,2006,49,3,971,408.43,0.9,131.23,0,Active
CHEMBL203312,OC1=C(C(=O)N(CCCC#C)c2ccccc12)C3=NS(=O)(=O)c4ccccc4N3,IC50,=,179,nM,6.747146969,Q8JXU8,Hepatitis C virus NS5B RNA-dependent RNA polymerase,CHEMBL1148625,Scientific Literature,Inhibitory activity against HCV delta 21 NS5B RNA polymerase by SPA assay,16451063,J. Med. Chem.,2006,49,3,971,407.44,2.57,107.44,0,Active
CHEMBL189927,OC(=O)\C(=C\c1ccc(Oc2ccccc2Br)cc1)\NC(=O)c3ccccc3F,IC50,=,180,nM,6.744727495,Q8JXU8,Hepatitis C virus NS5B RNA-dependent RNA polymerase,CHEMBL1145278,Scientific Literature,Inhibitory concentration against RNA dependent RNA polymerase Nonstructural protein 5B (HCV NS5B polymerase) in Hepatitis C virus,15911260,Bioorg. Med. Chem. Lett.,2005,15,11,2812,456.26,4.93,75.63,0,Active
CHEMBL215089,Cc1c(c2ccccc2)n(C3CCCCC3)c4ccc(cc14)C(=O)O,IC50,=,180,nM,6.744727495,Q8JXU8,Hepatitis C virus NS5B RNA-dependent RNA polymerase,CHEMBL1146881,Scientific Literature,Inhibition of HCV 1b NS5B delta21 RNA dependent RNA polymerase by SPA,16908138,Bioorg. Med. Chem. Lett.,2006,16,19,4987,333.42,6.11,42.23,1,Active
CHEMBL209921,Cc1ncc(COc2ccc(cc2)c3nc4cc(ccc4n3C5CCCCC5)C(=O)O)c(n1)c6ccc(Cl)cc6,IC50,=,188,nM,6.725842151,Q8JXU8,Hepatitis C virus NS5B RNA-dependent RNA polymerase,CHEMBL1138950,Scientific Literature,Inhibition of HCV 1b BK six His-tagged C-terminal truncated 544 amino acid NS5B RNA dependent RNA polymerase,16854079,J. Med. Chem.,2006,49,15,4721,553.05,7.32,90.13,2,Active
CHEMBL210541,CC(C)CCN1C(=O)C(=C(O)c2cccnc12)C3=NS(=O)(=O)c4cc(NS(=O)(=O)NC(=O)OCCCl)ccc4N3,IC50,=,189,nM,6.723538196,Q8JXU8,Hepatitis C virus NS5B RNA-dependent RNA polymerase,CHEMBL1138070,Scientific Literature,Inhibition of HCV 1a NS5B RNA polymerase,16650764,Bioorg. Med. Chem. Lett.,2006,16,13,3367,613.06,1.61,213.21,2,Active
CHEMBL201313,CCCC1(CC(=O)O)OCCc2c1sc3c(C)ccc(Br)c23,IC50,=,190,nM,6.721246399,Q8JXU8,Hepatitis C virus NS5B RNA-dependent RNA polymerase,CHEMBL1148590,Scientific Literature,Displacement of [alpha-32P]GTP from recombinant HCV NS5B RNA dependent RNA polymerase,16274990,Bioorg. Med. Chem. Lett.,2006,16,2,457,383.3,5.04,74.77,1,Active
CHEMBL205990,OC(=O)c1nc(nc(O)c1O)c2sccc2NC(=O)OCc3c(Cl)cccc3Cl,IC50,=,190,nM,6.721246399,Q8JXU8,Hepatitis C virus NS5B RNA-dependent RNA polymerase,CHEMBL1138187,Scientific Literature,Inhibitory activity against HCV 1b BK NS5B deltaC55 RNA polymerase,16509585,J. Med. Chem.,2006,49,5,1693,456.26,4.41,170.11,0,Active
CHEMBL202062,CC(C)CCN1C(=O)C(=C(O)c2cc(O)ccc12)C3=NS(=O)(=O)c4ccccc4N3,IC50,=,198,nM,6.70333481,Q8JXU8,Hepatitis C virus NS5B RNA-dependent RNA polymerase,CHEMBL1148625,Scientific Literature,Inhibitory activity against HCV delta 21 NS5B RNA polymerase by SPA assay,16451063,J. Med. Chem.,2006,49,3,971,427.47,1.94,127.68,0,Active
CHEMBL381033,C\C(=C/c1ccccc1)\C=C\2/SC(=S)N(NS(=O)(=O)c3ccccc3)C2=O,IC50,=,200,nM,6.698970004,Q8JXU8,Hepatitis C virus NS5B RNA-dependent RNA polymerase,CHEMBL1149391,Scientific Literature,Inhibitory activity against HCV delta 21 NS5b RNA polymerase,16451069,J. Med. Chem.,2006,49,3,1034,416.54,4.5,132.25,0,Active
CHEMBL201501,Fc1cc(F)c(\C=C\2/SC(=S)N(NS(=O)(=O)c3ccccc3)C2=O)cc1F,IC50,=,200,nM,6.698970004,Q8JXU8,Hepatitis C virus NS5B RNA-dependent RNA polymerase,CHEMBL1149391,Scientific Literature,Inhibitory activity against HCV delta 21 NS5b RNA polymerase,16451069,J. Med. Chem.,2006,49,3,1034,430.44,4.2,132.25,0,Active
CHEMBL440573,Brc1ccc(\C=C\2/SC(=S)N(NS(=O)(=O)c3ccccc3)C2=O)cc1Br,IC50,=,200,nM,6.698970004,Q8JXU8,Hepatitis C virus NS5B RNA-dependent RNA polymerase,CHEMBL1149391,Scientific Literature,Inhibitory activity against HCV delta 21 NS5b RNA polymerase,16451069,J. Med. Chem.,2006,49,3,1034,534.27,5.08,132.25,2,Active
CHEMBL203729,OC(=O)c1nc(nc(O)c1O)c2sccc2NC(=O)Cc3c[nH]c4ccccc34,IC50,=,200,nM,6.698970004,Q8JXU8,Hepatitis C virus NS5B RNA-dependent RNA polymerase,CHEMBL1138187,Scientific Literature,Inhibitory activity against HCV 1b BK NS5B deltaC55 RNA polymerase,16509585,J. Med. Chem.,2006,49,5,1693,410.4,2.85,176.67,0,Active
CHEMBL383596,CCOC(=O)c1c2CCC(C)Cc2sc1NC(=O)NS(=O)(=O)c3ccc(C)cc3,IC50,=,200,nM,6.698970004,Q8JXU8,Hepatitis C virus NS5B RNA-dependent RNA polymerase,CHEMBL1148540,Scientific Literature,Inhibitory activity against HCV 4a NS5B full length RNA dependent RNA polymerase,16260131,Bioorg. Med. Chem. Lett.,2006,16,1,100,436.54,4.21,138.18,0,Active
CHEMBL202580,Clc1ccc(\C=C\2/SC(=S)N(NS(=O)(=O)c3ccccc3)C2=O)cc1Cl,IC50,=,200,nM,6.698970004,Q8JXU8,Hepatitis C virus NS5B RNA-dependent RNA polymerase,CHEMBL3044858,Scientific Literature,Inhibition of Hepatitis C virus NS5B polymerase,NA,Med Chem Res,2013,22,2,707,445.36,4.91,132.25,0,Active
CHEMBL191977,OC(=O)\C(=C\c1ccc(Oc2ccccc2Br)cc1)\NC(=O)C3CCCCC3,IC50,=,200,nM,6.698970004,Q8JXU8,Hepatitis C virus NS5B RNA-dependent RNA polymerase,CHEMBL1145278,Scientific Literature,Inhibitory concentration against RNA dependent RNA polymerase Nonstructural protein 5B (HCV NS5B polymerase) in Hepatitis C virus,15911260,Bioorg. Med. Chem. Lett.,2005,15,11,2812,444.32,5.19,75.63,1,Active
CHEMBL212677,OC(=O)c1ccc2c(c1)nc(c3ccc(OCc4cc(Cl)ccc4c5ccccc5)cc3)n2C6CCCCC6,IC50,=,200,nM,6.698970004,Q8JXU8,Hepatitis C virus NS5B RNA-dependent RNA polymerase,CHEMBL1138950,Scientific Literature,Inhibition of HCV 1b BK six His-tagged C-terminal truncated 544 amino acid NS5B RNA dependent RNA polymerase,16854079,J. Med. Chem.,2006,49,15,4721,537.05,8.71,64.35,2,Active
CHEMBL380788,OC1N(NS(=O)(=O)c2ccccc2F)C(=S)S/C/1=C\c3ccc(Cl)c(Cl)c3,IC50,=,200,nM,6.698970004,Q8JXU8,Hepatitis C virus NS5B RNA-dependent RNA polymerase,CHEMBL1149391,Scientific Literature,Inhibitory activity against HCV delta 21 NS5b RNA polymerase,16451069,J. Med. Chem.,2006,49,3,1034,465.37,5.04,135.41,1,Active
CHEMBL194438,Cc1cccc(Cl)c1Oc2ccc(\C=C(/NC(=O)c3ccccc3)\C(=O)O)cc2,IC50,=,200,nM,6.698970004,Q8JXU8,Hepatitis C virus NS5B RNA-dependent RNA polymerase,CHEMBL1140265,Scientific Literature,Inhibitory concentration against Hepatitis C virus NS5B polymerase,15863301,Bioorg. Med. Chem. Lett.,2005,15,10,2481,407.85,5.13,75.63,1,Active
CHEMBL195476,OC(=O)\C(=C\c1ccc(Oc2ccccc2Cl)cc1)\NC(=O)c3ccccc3,IC50,=,200,nM,6.698970004,Q8JXU8,Hepatitis C virus NS5B RNA-dependent RNA polymerase,CHEMBL1140265,Scientific Literature,Inhibitory concentration against Hepatitis C virus NS5B polymerase,15863301,Bioorg. Med. Chem. Lett.,2005,15,10,2481,393.82,4.64,75.63,0,Active
CHEMBL201550,Clc1ccc(\C=C\2/SC(=S)N(NS(=O)(=O)c3cccs3)C2=O)cc1Cl,IC50,=,200,nM,6.698970004,Q8JXU8,Hepatitis C virus NS5B RNA-dependent RNA polymerase,CHEMBL1149391,Scientific Literature,Inhibitory activity against HCV delta 21 NS5b RNA polymerase,16451069,J. Med. Chem.,2006,49,3,1034,451.39,4.7,160.49,0,Active
CHEMBL201119,CC(C)CCN1C(=O)C(=C(O)c2cc(Br)ccc12)C3=NS(=O)(=O)c4ccccc4N3,IC50,=,205,nM,6.688246139,Q8JXU8,Hepatitis C virus NS5B RNA-dependent RNA polymerase,CHEMBL1148625,Scientific Literature,Inhibitory activity against HCV delta 21 NS5B RNA polymerase by SPA assay,16451063,J. Med. Chem.,2006,49,3,971,490.37,2.93,107.44,0,Active
CHEMBL201603,CC(C)CCN1C(=O)C(=C(O)c2c(C)cccc12)C3=NS(=O)(=O)c4ccccc4N3,IC50,=,206,nM,6.68613278,Q8JXU8,Hepatitis C virus NS5B RNA-dependent RNA polymerase,CHEMBL1148625,Scientific Literature,Inhibitory activity against HCV delta 21 NS5B RNA polymerase by SPA assay,16451063,J. Med. Chem.,2006,49,3,971,425.5,2.67,107.44,0,Active
CHEMBL217807,OC(=O)c1ccc2c(C3CCCCC3)c4c5ccccc5Cn4c2c1,IC50,=,210,nM,6.677780705,Q8JXU8,Hepatitis C virus NS5B RNA-dependent RNA polymerase,CHEMBL1137351,Scientific Literature,Inhibition of HCV NS5B RNA polymerase,17125247,J. Med. Chem.,2006,49,24,6950,331.41,5.71,42.23,1,Active
CHEMBL202911,OC(=O)c1nc(nc(O)c1O)c2sccc2NC(=O)Cc3ccccc3Cl,IC50,=,210,nM,6.677780705,Q8JXU8,Hepatitis C virus NS5B RNA-dependent RNA polymerase,CHEMBL1138187,Scientific Literature,Inhibitory activity against HCV 1b BK NS5B deltaC55 RNA polymerase,16509585,J. Med. Chem.,2006,49,5,1693,405.81,3.22,160.88,0,Active
CHEMBL202804,OC(=O)c1nc(nc(O)c1O)c2sccc2NC(=O)NCc3csc4ccccc34,IC50,=,220,nM,6.657577319,Q8JXU8,Hepatitis C virus NS5B RNA-dependent RNA polymerase,CHEMBL1138187,Scientific Literature,Inhibitory activity against HCV 1b BK NS5B deltaC55 RNA polymerase,16509585,J. Med. Chem.,2006,49,5,1693,442.47,3.3,201.15,0,Active
CHEMBL360266,OC1=C(C2=NS(=O)(=O)c3ccccc3N2)C(=O)N(NCc4cccnc4)c5ccccc15,IC50,=,221,nM,6.655607726,Q8JXU8,Hepatitis C virus NS5B RNA-dependent RNA polymerase,CHEMBL1142034,Scientific Literature,Inhibitory concentration against RNA dependent RNA polymerase Nonstructural protein 5B of genotype 1b Hepatitis C virus,15745800,Bioorg. Med. Chem. Lett.,2005,15,6,1577,447.47,0.54,132.37,0,Active
CHEMBL370754,CN(C)C1CCN(CC1)C(=O)Cn2c(C#C)c(C3CCCCC3)c4ccc(cc24)C(=O)O,IC50,=,228,nM,6.642065153,Q8JXU8,Hepatitis C virus NS5B RNA-dependent RNA polymerase,CHEMBL1140313,Scientific Literature,Inhibitory activity against by hepatitis C virus NS5B polymerase,15999993,J. Med. Chem.,2005,48,14,4547,435.56,1.91,65.78,0,Active
CHEMBL204663,OC(=O)c1nc(nc(O)c1O)c2sccc2NC(=O)Cc3csc4ccccc34,IC50,=,230,nM,6.638272164,Q8JXU8,Hepatitis C virus NS5B RNA-dependent RNA polymerase,CHEMBL1138187,Scientific Literature,Inhibitory activity against HCV 1b BK NS5B deltaC55 RNA polymerase,16509585,J. Med. Chem.,2006,49,5,1693,427.45,3.42,189.12,0,Active
CHEMBL371821,OC(=O)\C(=C\c1ccc(Oc2ccccc2Br)cc1)\NC(=O)c3ccc(F)c(F)c3,IC50,=,230,nM,6.638272164,Q8JXU8,Hepatitis C virus NS5B RNA-dependent RNA polymerase,CHEMBL1145278,Scientific Literature,Inhibitory concentration against RNA dependent RNA polymerase Nonstructural protein 5B (HCV NS5B polymerase) in Hepatitis C virus,15911260,Bioorg. Med. Chem. Lett.,2005,15,11,2812,474.25,5.14,75.63,1,Active
CHEMBL215848,CN(C)C(=O)Cn1c(c2ccccc2)c(C3CCCCC3)c4cc(sc14)C(=O)O,IC50,=,230,nM,6.638272164,Q8JXU8,Hepatitis C virus NS5B RNA-dependent RNA polymerase,CHEMBL1146030,Scientific Literature,Inhibition of HCV BK NS5B deltaC55 RNA dependent RNA polymerase,16714108,Bioorg. Med. Chem. Lett.,2006,16,15,4026,410.53,5.06,90.77,1,Active
CHEMBL177929,OC(=O)C(=O)\C=C(/O)\c1cccc(OCc2ccccc2C#N)c1,IC50,=,230,nM,6.638272164,Q8JXU8,Hepatitis C virus NS5B RNA-dependent RNA polymerase,CHEMBL1139456,Scientific Literature,Inhibitory activity against Hepatitis C virus RNA dependent RNA polymerase nonstructural protein 5B,14695815,J. Med. Chem.,2004,47,1,14,323.3,2.71,107.62,0,Active
CHEMBL192821,OC(=O)\C(=C\c1ccc(Oc2ccccc2Br)cc1)\NC(=O)c3ccc(F)cc3F,IC50,=,230,nM,6.638272164,Q8JXU8,Hepatitis C virus NS5B RNA-dependent RNA polymerase,CHEMBL1145278,Scientific Literature,Inhibitory concentration against RNA dependent RNA polymerase Nonstructural protein 5B (HCV NS5B polymerase) in Hepatitis C virus,15911260,Bioorg. Med. Chem. Lett.,2005,15,11,2812,474.25,5.14,75.63,1,Active
CHEMBL202895,OC(=O)c1nc(nc(O)c1O)c2sccc2NC(=O)NCc3ccccc3,IC50,=,230,nM,6.638272164,Q8JXU8,Hepatitis C virus NS5B RNA-dependent RNA polymerase,CHEMBL1138187,Scientific Literature,Inhibitory activity against HCV 1b BK NS5B deltaC55 RNA polymerase,16509585,J. Med. Chem.,2006,49,5,1693,386.38,2.44,172.91,0,Active
CHEMBL214031,OC(=O)c1ccc2c(C3CCCCC3)c([nH]c2c1)c4ccccn4,IC50,=,230,nM,6.638272164,Q8JXU8,Hepatitis C virus NS5B RNA-dependent RNA polymerase,CHEMBL1146881,Scientific Literature,Inhibition of HCV 1b NS5B delta21 RNA dependent RNA polymerase by SPA,16908138,Bioorg. Med. Chem. Lett.,2006,16,19,4987,320.39,5.03,65.97,1,Active
CHEMBL207911,OC(=O)[C@@H]1CSCN1S(=O)(=O)c2cc(Cl)cc(Cl)c2O,IC50,=,240,nM,6.619788758,Q8JXU8,Hepatitis C virus NS5B RNA-dependent RNA polymerase,CHEMBL1147722,Scientific Literature,Inhibition of HCV NS5B RNA dependent RNA polymerase,16722622,J. Med. Chem.,2006,49,11,3052,358.22,2.07,128.58,0,Active
CHEMBL189319,CN(C)C1CNC(C1)C(=O)Cn2c(c3ccccc3)c(C4CCCCC4)c5cc(ccc25)C(=O)O,IC50,=,244,nM,6.612610174,Q8JXU8,Hepatitis C virus NS5B RNA-dependent RNA polymerase,CHEMBL1140313,Scientific Literature,Inhibitory activity against by hepatitis C virus NS5B polymerase,15999993,J. Med. Chem.,2005,48,14,4547,473.61,2.49,74.57,0,Active
CHEMBL192831,Cc1ccc(cc1)C(=O)N\C(=C/c2ccc(Oc3ccccc3Br)cc2)\C(=O)O,IC50,=,250,nM,6.602059991,Q8JXU8,Hepatitis C virus NS5B RNA-dependent RNA polymerase,CHEMBL1145278,Scientific Literature,Inhibitory concentration against RNA dependent RNA polymerase Nonstructural protein 5B (HCV NS5B polymerase) in Hepatitis C virus,15911260,Bioorg. Med. Chem. Lett.,2005,15,11,2812,452.3,5.21,75.63,1,Active
CHEMBL210596,OC(=O)[C@@H]1CCCN1S(=O)(=O)c2cc(Cl)cc(Br)c2O,IC50,=,260,nM,6.585026652,Q8JXU8,Hepatitis C virus NS5B RNA-dependent RNA polymerase,CHEMBL1147722,Scientific Literature,Inhibition of HCV NS5B RNA dependent RNA polymerase,16722622,J. Med. Chem.,2006,49,11,3052,384.63,2.2,103.29,0,Active
CHEMBL214781,COc1ccc(CCC2(CC(=O)C(=C(O)O2)Sc3nnnn3C)C4CCCC4)cc1Cl,IC50,=,280,nM,6.552841969,Q8JXU8,Hepatitis C virus NS5B RNA-dependent RNA polymerase,CHEMBL1149470,Scientific Literature,Inhibitory activity against HCV 1b BK NS5B deltaC21 RNA polymerase,16824756,Bioorg. Med. Chem. Lett.,2006,16,18,4834,464.97,4.64,124.66,0,Active
CHEMBL205118,OC(=O)c1nc(nc(O)c1O)c2sccc2NC(=O)Cc3c([nH]c4ccccc34)c5ccccc5,IC50,=,280,nM,6.552841969,Q8JXU8,Hepatitis C virus NS5B RNA-dependent RNA polymerase,CHEMBL1138187,Scientific Literature,Inhibitory activity against HCV 1b BK NS5B deltaC55 RNA polymerase,16509585,J. Med. Chem.,2006,49,5,1693,486.5,4.66,176.67,0,Active
CHEMBL191207,CCc1c(C2CCCCC2)c3ccc(cc3n1CC(=O)N4CCC(CC4)N(C)C)C(=O)O,IC50,=,283,nM,6.548213564,Q8JXU8,Hepatitis C virus NS5B RNA-dependent RNA polymerase,CHEMBL1140313,Scientific Literature,Inhibitory activity against by hepatitis C virus NS5B polymerase,15999993,J. Med. Chem.,2005,48,14,4547,439.59,1.3,65.78,0,Active
CHEMBL381218,CC(=CCN1C(=O)C(=C(O)c2ccccc12)C3=NS(=O)(=O)c4ccccc4N3)C,IC50,=,289,nM,6.539102157,Q8JXU8,Hepatitis C virus NS5B RNA-dependent RNA polymerase,CHEMBL1148625,Scientific Literature,Inhibitory activity against HCV delta 21 NS5B RNA polymerase by SPA assay,16451063,J. Med. Chem.,2006,49,3,971,409.46,2.07,107.44,0,Active
CHEMBL214595,Cn1c(c2cocc2)c(C3CCCC3)c4ccc(C(=O)O)c(Cl)c14,IC50,=,290,nM,6.537602002,Q8JXU8,Hepatitis C virus NS5B RNA-dependent RNA polymerase,CHEMBL1146881,Scientific Literature,Inhibition of HCV 1b NS5B delta21 RNA dependent RNA polymerase by SPA,16908138,Bioorg. Med. Chem. Lett.,2006,16,19,4987,343.8,5.27,55.37,1,Active
CHEMBL209282,OC(=O)c1ccc2c(c1)nc(c3ccc(OCc4cc(Cl)ccc4c5cccnc5)cc3)n2C6CCCCC6,IC50,=,290,nM,6.537602002,Q8JXU8,Hepatitis C virus NS5B RNA-dependent RNA polymerase,CHEMBL1138950,Scientific Literature,Inhibition of HCV 1b BK six His-tagged C-terminal truncated 544 amino acid NS5B RNA dependent RNA polymerase,16854079,J. Med. Chem.,2006,49,15,4721,538.04,7.56,77.24,2,Active
CHEMBL201815,CC(Br)CCN1C(=O)C(=C(O)c2ccccc12)C3=NS(=O)(=O)c4ccccc4N3,IC50,=,290,nM,6.537602002,Q8JXU8,Hepatitis C virus NS5B RNA-dependent RNA polymerase,CHEMBL1148625,Scientific Literature,Inhibitory activity against HCV delta 21 NS5B RNA polymerase by SPA assay,16451063,J. Med. Chem.,2006,49,3,971,476.34,1.85,107.44,0,Active
CHEMBL204321,OC(=O)c1nc(nc(O)c1O)c2sccc2NC(=O)OCc3ccccc3,IC50,=,290,nM,6.537602002,Q8JXU8,Hepatitis C virus NS5B RNA-dependent RNA polymerase,CHEMBL1138187,Scientific Literature,Inhibitory activity against HCV 1b BK NS5B deltaC55 RNA polymerase,16509585,J. Med. Chem.,2006,49,5,1693,387.37,3.09,170.11,0,Active
CHEMBL377598,OC(=O)c1ccc2c(c1)nc(c3ccc(OCc4ccccc4c5ccccc5)cc3)n2C6CCCCC6,IC50,=,300,nM,6.522878745,Q8JXU8,Hepatitis C virus NS5B RNA-dependent RNA polymerase,CHEMBL1146135,Scientific Literature,Inhibitory activity against HCV 1b NS5B RNA dependent RNA polymerase,16455252,Bioorg. Med. Chem. Lett.,2006,16,7,1859,502.6,8.05,64.35,2,Active
CHEMBL201873,Cc1nc(CN2C(=O)C(=C(O)c3ccccc23)C4=NS(=O)(=O)c5ccccc5N4)cs1,IC50,=,304,nM,6.517126416,Q8JXU8,Hepatitis C virus NS5B RNA-dependent RNA polymerase,CHEMBL1148625,Scientific Literature,Inhibitory activity against HCV delta 21 NS5B RNA polymerase by SPA assay,16451063,J. Med. Chem.,2006,49,3,971,452.51,1.12,148.57,0,Active
CHEMBL371573,Nc1cccc(Cl)c1Oc2ccc(\C=C(/NC(=O)c3ccccc3)\C(=O)O)cc2,IC50,=,310,nM,6.508638306,Q8JXU8,Hepatitis C virus NS5B RNA-dependent RNA polymerase,CHEMBL1140265,Scientific Literature,Inhibitory concentration against Hepatitis C virus NS5B polymerase,15863301,Bioorg. Med. Chem. Lett.,2005,15,10,2481,408.83,3.89,101.65,0,Active
CHEMBL202514,OC1=C(C2=NS(=O)(=O)c3ccccc3N2)C(=O)N(Cc4cccnc4)c5ccccc15,IC50,=,316,nM,6.500312917,Q8JXU8,Hepatitis C virus NS5B RNA-dependent RNA polymerase,CHEMBL1148625,Scientific Literature,Inhibitory activity against HCV delta 21 NS5B RNA polymerase by SPA assay,16451063,J. Med. Chem.,2006,49,3,971,432.45,1.03,120.33,0,Active
CHEMBL378758,CN(C)C(=O)Cn1c(c2ccccc2)c(C3CCCCC3)c4ccc(nc14)C(=O)O,IC50,=,320,nM,6.494850022,Q8JXU8,Hepatitis C virus NS5B RNA-dependent RNA polymerase,CHEMBL1146030,Scientific Literature,Inhibition of HCV BK NS5B deltaC55 RNA dependent RNA polymerase,16714108,Bioorg. Med. Chem. Lett.,2006,16,15,4026,405.49,4.7,75.42,0,Active
CHEMBL201475,CCCC1(CC(=O)O)OCCc2c1sc3c(C)ccc(C#N)c23,IC50,=,320,nM,6.494850022,Q8JXU8,Hepatitis C virus NS5B RNA-dependent RNA polymerase,CHEMBL1148590,Scientific Literature,Displacement of [alpha-32P]GTP from recombinant HCV NS5B RNA dependent RNA polymerase,16274990,Bioorg. Med. Chem. Lett.,2006,16,2,457,329.41,4.17,98.56,0,Active
CHEMBL363830,CN(C)C(=O)Cn1c(c2cccnc2)c(C3CCCCC3)c4ccc(cc14)C(=O)O,IC50,=,332,nM,6.478861916,Q8JXU8,Hepatitis C virus NS5B RNA-dependent RNA polymerase,CHEMBL1140313,Scientific Literature,Inhibitory activity against by hepatitis C virus NS5B polymerase,15999993,J. Med. Chem.,2005,48,14,4547,405.49,4.08,75.43,0,Active
CHEMBL202315,CC(C)CCN1C(=O)C(=C(O)c2c1cccc2[N+](=O)[O-])C3=NS(=O)(=O)c4ccccc4N3,IC50,=,338,nM,6.4710833,Q8JXU8,Hepatitis C virus NS5B RNA-dependent RNA polymerase,CHEMBL1148625,Scientific Literature,Inhibitory activity against HCV delta 21 NS5B RNA polymerase by SPA assay,16451063,J. Med. Chem.,2006,49,3,971,456.47,2.08,153.26,0,Active
CHEMBL208507,OC(=O)c1ccc2c(c1)nc(c3ccc(OCCc4ccccc4c5ccccc5)cc3)n2C6CCCCC6,IC50,=,340,nM,6.468521083,Q8JXU8,Hepatitis C virus NS5B RNA-dependent RNA polymerase,CHEMBL1146135,Scientific Literature,Inhibitory activity against HCV 1b NS5B RNA dependent RNA polymerase,16455252,Bioorg. Med. Chem. Lett.,2006,16,7,1859,516.63,8.37,64.35,2,Active
CHEMBL202513,CC(C)CCN1C(=O)C(=C(O)c2c(F)cccc12)C3=NS(=O)(=O)c4ccccc4N3,IC50,=,340,nM,6.468521083,Q8JXU8,Hepatitis C virus NS5B RNA-dependent RNA polymerase,CHEMBL1148625,Scientific Literature,Inhibitory activity against HCV delta 21 NS5B RNA polymerase by SPA assay,16451063,J. Med. Chem.,2006,49,3,971,429.46,2.39,107.44,0,Active
CHEMBL178087,OC(=O)c1ccc2c(c1)cc(c3ccc(O)cc3)n2C4CCCCC4,IC50,=,340,nM,6.468521083,Q8JXU8,Hepatitis C virus NS5B RNA-dependent RNA polymerase,CHEMBL1142688,Scientific Literature,Inhibitory concentration against RNA dependent RNA polymerase nonstructural protein 5B of hepatitis C virus,15743173,J. Med. Chem.,2005,48,5,1314,335.4,5.39,62.46,1,Active
CHEMBL384028,COc1c(ccc2c(C3CCCC3)c(c4cocc4)n(C)c12)C(=O)O,IC50,=,340,nM,6.468521083,Q8JXU8,Hepatitis C virus NS5B RNA-dependent RNA polymerase,CHEMBL1146881,Scientific Literature,Inhibition of HCV 1b NS5B delta21 RNA dependent RNA polymerase by SPA,16908138,Bioorg. Med. Chem. Lett.,2006,16,19,4987,339.39,4.59,64.6,0,Active
CHEMBL175171,OC(=O)C(=O)CC(=O)c1ccccc1OCCCC#N,IC50,=,350,nM,6.455931956,Q8JXU8,Hepatitis C virus NS5B RNA-dependent RNA polymerase,CHEMBL1139456,Scientific Literature,Inhibitory activity against Hepatitis C virus RNA dependent RNA polymerase nonstructural protein 5B,14695815,J. Med. Chem.,2004,47,1,14,275.26,1.54,104.46,0,Active
CHEMBL379796,OC(=O)c1ccc2c(c1)nc(c3ccc(OCc4ccccc4c5ccccc5)cc3Cl)n2C6CCCCC6,IC50,=,350,nM,6.455931956,Q8JXU8,Hepatitis C virus NS5B RNA-dependent RNA polymerase,CHEMBL1138950,Scientific Literature,Inhibition of HCV 1b BK six His-tagged C-terminal truncated 544 amino acid NS5B RNA dependent RNA polymerase,16854079,J. Med. Chem.,2006,49,15,4721,537.05,8.71,64.35,2,Active
CHEMBL202539,OC1=C(C(=O)N(CC2CCCCC2)c3ccccc13)C4=NS(=O)(=O)c5ccccc5N4,IC50,=,367,nM,6.435333936,Q8JXU8,Hepatitis C virus NS5B RNA-dependent RNA polymerase,CHEMBL1148625,Scientific Literature,Inhibitory activity against HCV delta 21 NS5B RNA polymerase by SPA assay,16451063,J. Med. Chem.,2006,49,3,971,437.51,2.79,107.44,0,Active
CHEMBL426277,OC(=O)\C(=C\c1ccc(Oc2ccccc2Br)cc1)\NC(=O)CCc3ccc(cc3)C(F)(F)F,IC50,=,370,nM,6.431798276,Q8JXU8,Hepatitis C virus NS5B RNA-dependent RNA polymerase,CHEMBL1145278,Scientific Literature,Inhibitory concentration against RNA dependent RNA polymerase Nonstructural protein 5B (HCV NS5B polymerase) in Hepatitis C virus,15911260,Bioorg. Med. Chem. Lett.,2005,15,11,2812,534.32,6.16,75.63,2,Active
CHEMBL369552,CN(C)C(=O)Cn1c(c2ccccc2Cl)c(C3CCCCC3)c4ccc(cc14)C(=O)O,IC50,=,372,nM,6.42945706,Q8JXU8,Hepatitis C virus NS5B RNA-dependent RNA polymerase,CHEMBL1142688,Scientific Literature,Inhibitory activity against RNA dependent RNA polymerase nonstructural protein 5B in hepatitis C virus; n=1,15743173,J. Med. Chem.,2005,48,5,1314,438.95,5.89,62.54,1,Active
CHEMBL196154,OC(=O)C(=O)\C=C(/O)\c1ccccc1OCCCC#N,IC50,=,380,nM,6.420216403,Q8JXU8,Hepatitis C virus NS5B RNA-dependent RNA polymerase,CHEMBL1140440,Scientific Literature,"Inhibitory concentration against NS5B HCV polymerase using [alpha-32P]UTP as radioligand (30 degree C for 2 h, at pH 7.5 with Tris-HCl buffer)",16190757,J. Med. Chem.,2005,48,20,6304,275.26,1.55,107.62,0,Active
CHEMBL377907,OC(=O)c1ccc2c(c1)nc(c3ccc(OCc4ccccc4c5ccccc5)c(F)c3)n2C6CCCCC6,IC50,=,380,nM,6.420216403,Q8JXU8,Hepatitis C virus NS5B RNA-dependent RNA polymerase,CHEMBL1138950,Scientific Literature,Inhibition of HCV 1b BK six His-tagged C-terminal truncated 544 amino acid NS5B RNA dependent RNA polymerase,16854079,J. Med. Chem.,2006,49,15,4721,520.59,8.26,64.35,2,Active
CHEMBL380462,OC(=O)c1nc(nc(O)c1O)c2sccc2NC(=O)Cc3ccccc3,IC50,=,380,nM,6.420216403,Q8JXU8,Hepatitis C virus NS5B RNA-dependent RNA polymerase,CHEMBL1138187,Scientific Literature,Inhibitory activity against HCV 1b BK NS5B deltaC55 RNA polymerase,16509585,J. Med. Chem.,2006,49,5,1693,371.37,2.56,160.88,0,Active
CHEMBL205337,OC(=O)c1ccc2c(c1)nc(c3ccc(OCc4cccc(c4)c5ccccc5)cc3)n2C6CCCCC6,IC50,=,390,nM,6.408935393,Q8JXU8,Hepatitis C virus NS5B RNA-dependent RNA polymerase,CHEMBL1146135,Scientific Literature,Inhibitory activity against HCV 1b NS5B RNA dependent RNA polymerase,16455252,Bioorg. Med. Chem. Lett.,2006,16,7,1859,502.6,8.05,64.35,2,Active
CHEMBL369397,COc1ccc2[nH]cc(C[C@H](NC(=O)c3ccc4c(c3)nc(c5cocc5)n4C6CCCCC6)C(=O)O)c2c1,IC50,=,400,nM,6.397940009,Q8JXU8,Hepatitis C virus NS5B RNA-dependent RNA polymerase,CHEMBL1149207,Scientific Literature,Concentration required for inhibiting hepatitis C virus NS5B RNA polymerase activity.,15013003,Bioorg. Med. Chem. Lett.,2004,14,4,967,526.58,5.45,122.38,2,Active
CHEMBL174225,OC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)c2ccc3c(c2)nc(c4cocc4)n3C5CCCCC5,IC50,=,400,nM,6.397940009,Q8JXU8,Hepatitis C virus NS5B RNA-dependent RNA polymerase,CHEMBL1149207,Scientific Literature,Concentration required for inhibiting hepatitis C virus NS5B RNA polymerase activity.,15013003,Bioorg. Med. Chem. Lett.,2004,14,4,967,473.52,4.93,117.59,0,Active
CHEMBL353549,OC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)c3ccc4c(c3)nc(c5cocc5)n4C6CCCCC6,IC50,=,400,nM,6.397940009,Q8JXU8,Hepatitis C virus NS5B RNA-dependent RNA polymerase,CHEMBL1149207,Scientific Literature,Concentration required for inhibiting hepatitis C virus NS5B RNA polymerase activity.,15013003,Bioorg. Med. Chem. Lett.,2004,14,4,967,496.56,5.46,113.15,1,Active
CHEMBL177283,COc1ccc(cc1OC)[C@H](NC(=O)c2ccc3c(c2)nc(c4cocc4)n3C5CCCCC5)C(=O)O,IC50,=,400,nM,6.397940009,Q8JXU8,Hepatitis C virus NS5B RNA-dependent RNA polymerase,CHEMBL1149207,Scientific Literature,Concentration required for inhibiting hepatitis C virus NS5B RNA polymerase activity.,15013003,Bioorg. Med. Chem. Lett.,2004,14,4,967,503.55,4.81,115.82,1,Active
CHEMBL181634,CC(C)C[C@]1(C[C@@H]([C@@H](N1C(=O)c2ccc(cc2)C(F)(F)F)c3nccs3)C(=O)O)C(=O)O,IC50,=,400,nM,6.397940009,Q8JXU8,Hepatitis C virus NS5B RNA-dependent RNA polymerase,CHEMBL1142030,Scientific Literature,Inhibitory concentration against Hepatitis C virus RNA dependent RNA polymerase Nonstructural protein 5B,15745795,Bioorg. Med. Chem. Lett.,2005,15,6,1553,470.46,3.49,136.04,0,Active
CHEMBL195832,OC(=O)c1ccccc1NC(=O)\C(=C\c2ccc(Oc3ccccc3Br)cc2)\NC(=O)c4ccccc4,IC50,=,400,nM,6.397940009,Q8JXU8,Hepatitis C virus NS5B RNA-dependent RNA polymerase,CHEMBL1145278,Scientific Literature,Inhibitory concentration against RNA dependent RNA polymerase Nonstructural protein 5B (HCV NS5B polymerase) in Hepatitis C virus,15911260,Bioorg. Med. Chem. Lett.,2005,15,11,2812,557.39,5.51,104.73,2,Active
CHEMBL193241,CN1CCN(CC1)C(=O)Cn2c(c3ccccc3)c(C4CCCCC4)c5cc(ccc25)C(=O)O,IC50,=,448,nM,6.348721986,Q8JXU8,Hepatitis C virus NS5B RNA-dependent RNA polymerase,CHEMBL1140313,Scientific Literature,Inhibitory activity against by hepatitis C virus NS5B polymerase,15999993,J. Med. Chem.,2005,48,14,4547,459.58,2.15,65.78,0,Active
CHEMBL378164,CC(C)CCN1C(=O)C(=C(O)c2cc(ccc12)[N+](=O)[O-])C3=NS(=O)(=O)c4ccccc4N3,IC50,=,455,nM,6.341988603,Q8JXU8,Hepatitis C virus NS5B RNA-dependent RNA polymerase,CHEMBL1148625,Scientific Literature,Inhibitory activity against HCV delta 21 NS5B RNA polymerase by SPA assay,16451063,J. Med. Chem.,2006,49,3,971,456.47,2.08,153.26,0,Active
CHEMBL379881,OC(=O)c1nc(nc(O)c1O)c2sccc2NC(=O)OCCc3ccccc3,IC50,=,460,nM,6.337242168,Q8JXU8,Hepatitis C virus NS5B RNA-dependent RNA polymerase,CHEMBL1138187,Scientific Literature,Inhibitory activity against HCV 1b BK NS5B deltaC55 RNA polymerase,16509585,J. Med. Chem.,2006,49,5,1693,401.39,3.41,170.11,0,Active
CHEMBL368163,Cc1[nH]c2ccc(O)cc2c1C[C@H](NC(=O)c3ccc4c(c3)nc(c5cocc5)n4C6CCCCC6)C(=O)O,IC50,=,460,nM,6.337242168,Q8JXU8,Hepatitis C virus NS5B RNA-dependent RNA polymerase,CHEMBL1149207,Scientific Literature,Concentration required for inhibiting hepatitis C virus NS5B RNA polymerase activity.,15013003,Bioorg. Med. Chem. Lett.,2004,14,4,967,526.58,5.37,133.38,2,Active
CHEMBL213819,COC(=O)c1c(ccc2c(C3CCCC3)c(c4cocc4)n(C)c12)C(=O)O,IC50,=,480,nM,6.318758763,Q8JXU8,Hepatitis C virus NS5B RNA-dependent RNA polymerase,CHEMBL1146881,Scientific Literature,Inhibition of HCV 1b NS5B delta21 RNA dependent RNA polymerase by SPA,16908138,Bioorg. Med. Chem. Lett.,2006,16,19,4987,367.4,4.46,81.67,0,Active
CHEMBL378284,OC(=O)c1ccc2c(c1)nc(c3ccc(OCc4cc(Cl)ccc4c5cccc(Cl)c5)cc3)n2C6CCCCC6,IC50,=,480,nM,6.318758763,Q8JXU8,Hepatitis C virus NS5B RNA-dependent RNA polymerase,CHEMBL1138950,Scientific Literature,Inhibition of HCV 1b BK six His-tagged C-terminal truncated 544 amino acid NS5B RNA dependent RNA polymerase,16854079,J. Med. Chem.,2006,49,15,4721,571.49,9.38,64.35,2,Active
CHEMBL381310,OC1=C(C(=O)N(CC2CCOC2)c3ccccc13)C4=NS(=O)(=O)c5ccccc5N4,IC50,=,484,nM,6.315154638,Q8JXU8,Hepatitis C virus NS5B RNA-dependent RNA polymerase,CHEMBL1148625,Scientific Literature,Inhibitory activity against HCV delta 21 NS5B RNA polymerase by SPA assay,16451063,J. Med. Chem.,2006,49,3,971,425.46,0.57,116.68,0,Active
CHEMBL179318,OC(=O)c1ccc2c(C3CCCCC3)c(c4ccccc4)n(c2c1)S(=O)(=O)c5ccccc5,IC50,=,485,nM,6.314258261,Q8JXU8,Hepatitis C virus NS5B RNA-dependent RNA polymerase,CHEMBL1142688,Scientific Literature,Inhibitory activity against RNA dependent RNA polymerase nonstructural protein 5B in hepatitis C virus; n=1,15743173,J. Med. Chem.,2005,48,5,1314,459.56,7.11,84.75,1,Active
CHEMBL203783,CC(C)(C)CCN1[C@@H](C2CCCCC2)C(=C(C1=O)C3=NS(=O)(=O)c4ccccc4N3)O,IC50,=,486,nM,6.313363731,Q8JXU8,Hepatitis C virus NS5B RNA-dependent RNA polymerase,CHEMBL1146957,Scientific Literature,Inhibition of HCV NS5B RNA dependent RNA polymerase,16455253,Bioorg. Med. Chem. Lett.,2006,16,8,2205,445.57,3.74,107.45,0,Active
CHEMBL184500,COc1ccc2c(cccc2c1C(F)(F)F)C(=O)NC(CCC(=O)O)C(=O)O,IC50,=,490,nM,6.30980392,Q8JXU8,Hepatitis C virus NS5B RNA-dependent RNA polymerase,CHEMBL1137155,Scientific Literature,Inhibitory concentration against HCV NS5B RNA dependent RNA polymerase,15261274,Bioorg. Med. Chem. Lett.,2004,14,16,4221,399.32,2.54,112.93,0,Active
CHEMBL199678,CCOC(=O)c1c2CC(C)CCc2sc1NC(=O)NS(=O)(=O)c3ccc(C)cc3,IC50,=,500,nM,6.301029996,Q8JXU8,Hepatitis C virus NS5B RNA-dependent RNA polymerase,CHEMBL1148540,Scientific Literature,Inhibitory activity against HCV 4a NS5B full length RNA dependent RNA polymerase,16260131,Bioorg. Med. Chem. Lett.,2006,16,1,100,436.54,4.21,138.18,0,Active
CHEMBL182020,Oc1ncnc2nc(c3ccc(F)cc3)c(nc12)c4ccc(F)cc4,IC50,=,500,nM,6.301029996,Q8JXU8,Hepatitis C virus NS5B RNA-dependent RNA polymerase,CHEMBL1144286,Scientific Literature,Inhibitory concentration against RNA dependent RNA polymerase Nonstructural protein 5B of hepatitis C virus,15664835,Bioorg. Med. Chem. Lett.,2005,15,3,675,336.3,4.31,71.79,0,Active
CHEMBL194554,NC(=O)\C(=C\c1ccc(Oc2ccccc2Br)cc1)\NC(=O)c3ccccc3,IC50,=,500,nM,6.301029996,Q8JXU8,Hepatitis C virus NS5B RNA-dependent RNA polymerase,CHEMBL1145278,Scientific Literature,Inhibitory concentration against RNA dependent RNA polymerase Nonstructural protein 5B (HCV NS5B polymerase) in Hepatitis C virus,15911260,Bioorg. Med. Chem. Lett.,2005,15,11,2812,437.29,4.1,81.42,0,Active
CHEMBL372998,OC1N(NS(=O)(=O)c2ccc(Cl)cc2)C(=S)S/C/1=C\c3ccc(Cl)c(Cl)c3,IC50,=,500,nM,6.301029996,Q8JXU8,Hepatitis C virus NS5B RNA-dependent RNA polymerase,CHEMBL1149391,Scientific Literature,Inhibitory activity against HCV delta 21 NS5b RNA polymerase,16451069,J. Med. Chem.,2006,49,3,1034,481.82,5.5,135.41,1,Active
CHEMBL360456,CC(C)C[C@]1(C[C@@H]([C@H](C(C)C)N1C(=O)c2ccc(cc2)C(F)(F)F)C(=O)O)C(=O)O,IC50,=,500,nM,6.301029996,Q8JXU8,Hepatitis C virus NS5B RNA-dependent RNA polymerase,CHEMBL1142030,Scientific Literature,Inhibitory concentration against Hepatitis C virus RNA dependent RNA polymerase Nonstructural protein 5B,15745795,Bioorg. Med. Chem. Lett.,2005,15,6,1553,429.43,4.35,94.91,0,Active
CHEMBL195549,OC(=O)\C(=C\c1ccc(Oc2ccccc2Br)cc1)\NC(=O)CCc3ccc(Cl)cc3,IC50,=,500,nM,6.301029996,Q8JXU8,Hepatitis C virus NS5B RNA-dependent RNA polymerase,CHEMBL1145278,Scientific Literature,Inhibitory concentration against RNA dependent RNA polymerase Nonstructural protein 5B (HCV NS5B polymerase) in Hepatitis C virus,15911260,Bioorg. Med. Chem. Lett.,2005,15,11,2812,500.77,5.88,75.63,2,Active
CHEMBL201140,OC1=C(C(=O)N(CC2CCCO2)c3ccccc13)C4=NS(=O)(=O)c5ccccc5N4,IC50,=,528,nM,6.277366077,Q8JXU8,Hepatitis C virus NS5B RNA-dependent RNA polymerase,CHEMBL1148625,Scientific Literature,Inhibitory activity against HCV delta 21 NS5B RNA polymerase by SPA assay,16451063,J. Med. Chem.,2006,49,3,971,425.46,0.96,116.68,0,Active
CHEMBL383501,CC(C)(C)[C@@H]1N(CCC2CC2)C(=O)C(=C1O)C3=NS(=O)(=O)c4ccccc4N3,IC50,=,530,nM,6.27572413,Q8JXU8,Hepatitis C virus NS5B RNA-dependent RNA polymerase,CHEMBL1146957,Scientific Literature,Inhibition of HCV NS5B RNA dependent RNA polymerase,16455253,Bioorg. Med. Chem. Lett.,2006,16,8,2205,403.5,1.79,107.45,0,Active
CHEMBL214171,CC(C)Oc1ccc(CCC2(CC(=O)CC(=O)O2)C3CCCC3)cc1F,IC50,=,530,nM,6.27572413,Q8JXU8,Hepatitis C virus NS5B RNA-dependent RNA polymerase,CHEMBL1149470,Scientific Literature,Inhibitory activity against HCV 1b BK NS5B deltaC21 RNA polymerase,16824756,Bioorg. Med. Chem. Lett.,2006,16,18,4834,362.44,4.76,52.6,0,Active
CHEMBL202581,CC(C)CCN1C(=O)C(=C(O)c2ccc(F)cc12)C3=NS(=O)(=O)c4ccccc4N3,IC50,=,554,nM,6.256490235,Q8JXU8,Hepatitis C virus NS5B RNA-dependent RNA polymerase,CHEMBL1148625,Scientific Literature,Inhibitory activity against HCV delta 21 NS5B RNA polymerase by SPA assay,16451063,J. Med. Chem.,2006,49,3,971,429.46,2.39,107.44,0,Active
CHEMBL427410,COc1ccc(CCC2(CC(=O)C(=C(O)O2)Sc3ccccc3)C4CCCC4)cc1Cl,IC50,=,560,nM,6.251811973,Q8JXU8,Hepatitis C virus NS5B RNA-dependent RNA polymerase,CHEMBL1149470,Scientific Literature,Inhibitory activity against HCV 1b BK NS5B deltaC21 RNA polymerase,16824756,Bioorg. Med. Chem. Lett.,2006,16,18,4834,459,6.79,81.06,1,Active
CHEMBL378114,Oc1c(Cl)cc(Cl)cc1S(=O)(=O)N2CCC[C@H]2c3nn[nH]n3,IC50,=,560,nM,6.251811973,Q8JXU8,Hepatitis C virus NS5B RNA-dependent RNA polymerase,CHEMBL1147722,Scientific Literature,Inhibition of HCV NS5B RNA dependent RNA polymerase,16722622,J. Med. Chem.,2006,49,11,3052,364.21,1.95,120.45,0,Active
CHEMBL206865,CCCC1(CC(=O)O)OCCc2c1[nH]c3c(C)ccc(C#N)c23,IC50,=,570,nM,6.244125144,Q8JXU8,Hepatitis C virus NS5B RNA-dependent RNA polymerase,CHEMBL1147645,Scientific Literature,Inhibition of HCV 1b BK NS5B RNA polymerase,16480869,Bioorg. Med. Chem. Lett.,2006,16,9,2532,312.36,3.6,86.11,0,Active
CHEMBL379241,OC(=O)c1ccc2c(c1)nc(c3ccc(Oc4ccccc4c5ccccc5)cc3)n2C6CCCCC6,IC50,=,580,nM,6.236572006,Q8JXU8,Hepatitis C virus NS5B RNA-dependent RNA polymerase,CHEMBL1146135,Scientific Literature,Inhibitory activity against HCV 1b NS5B RNA dependent RNA polymerase,16455252,Bioorg. Med. Chem. Lett.,2006,16,7,1859,488.58,8.04,64.35,1,Active
CHEMBL380869,OC(=O)c1nc(nc(O)c1O)c2sccc2NC(=O)Nc3ccccc3,IC50,=,580,nM,6.236572006,Q8JXU8,Hepatitis C virus NS5B RNA-dependent RNA polymerase,CHEMBL1138187,Scientific Literature,Inhibitory activity against HCV 1b BK NS5B deltaC55 RNA polymerase,16509585,J. Med. Chem.,2006,49,5,1693,372.36,2.43,172.91,0,Active
CHEMBL373305,Cc1ccccc1Oc2ccc(\C=C(/NC(=O)c3ccccc3)\C(=O)O)cc2,IC50,=,580,nM,6.236572006,Q8JXU8,Hepatitis C virus NS5B RNA-dependent RNA polymerase,CHEMBL1140265,Scientific Literature,Inhibitory concentration against Hepatitis C virus NS5B polymerase,15863301,Bioorg. Med. Chem. Lett.,2005,15,10,2481,373.4,4.46,75.63,0,Active
CHEMBL203383,OC(=O)c1nc(nc(O)c1O)c2sccc2NC(=O)CCc3ccccc3,IC50,=,580,nM,6.236572006,Q8JXU8,Hepatitis C virus NS5B RNA-dependent RNA polymerase,CHEMBL1138187,Scientific Literature,Inhibitory activity against HCV 1b BK NS5B deltaC55 RNA polymerase,16509585,J. Med. Chem.,2006,49,5,1693,385.39,3.01,160.88,0,Active
CHEMBL208843,Cc1oc(c(COc2ccc(cc2)c3nc4cc(ccc4n3C5CCCCC5)C(=O)O)n1)c6ccc(Cl)cc6,IC50,=,580,nM,6.236572006,Q8JXU8,Hepatitis C virus NS5B RNA-dependent RNA polymerase,CHEMBL1138950,Scientific Literature,Inhibition of HCV 1b BK six His-tagged C-terminal truncated 544 amino acid NS5B RNA dependent RNA polymerase,16854079,J. Med. Chem.,2006,49,15,4721,542.02,7.38,90.38,2,Active
CHEMBL425352,COc1ccc2c(cccc2c1Br)C(=O)NC(CCC(=O)O)C(=O)O,IC50,=,590,nM,6.229147988,Q8JXU8,Hepatitis C virus NS5B RNA-dependent RNA polymerase,CHEMBL1137155,Scientific Literature,Inhibitory concentration against HCV NS5B RNA dependent RNA polymerase,15261274,Bioorg. Med. Chem. Lett.,2004,14,16,4221,410.22,2.35,112.93,0,Active
CHEMBL179389,CC(C)C[C@]1(C[C@@H]([C@@H](N1C(=O)c2ccc(Cl)c(Cl)c2)c3cccs3)C(=O)O)C(=O)O,IC50,=,600,nM,6.22184875,Q8JXU8,Hepatitis C virus NS5B RNA-dependent RNA polymerase,CHEMBL1142030,Scientific Literature,Inhibitory concentration against Hepatitis C virus RNA dependent RNA polymerase Nonstructural protein 5B,15745795,Bioorg. Med. Chem. Lett.,2005,15,6,1553,470.37,4.97,123.15,0,Active
CHEMBL180099,CC(C)C[C@]1(C[C@@H]([C@@H](N1C(=O)c2cccc(c2)C(F)(F)F)c3cccs3)C(=O)O)C(=O)O,IC50,=,600,nM,6.22184875,Q8JXU8,Hepatitis C virus NS5B RNA-dependent RNA polymerase,CHEMBL1142030,Scientific Literature,Inhibitory concentration against Hepatitis C virus RNA dependent RNA polymerase Nonstructural protein 5B,15745795,Bioorg. Med. Chem. Lett.,2005,15,6,1553,469.47,4.59,123.15,0,Active
CHEMBL73502,NC1=Nc2c(ncn2[C@@H]3O[C@H](CO)C[C@H]3O)C(=O)N1,IC50,=,600,nM,6.22184875,Q8JXU8,Hepatitis C virus NS5B RNA-dependent RNA polymerase,CHEMBL1149159,Scientific Literature,Inhibition HCV NS5B-mediated RNA synthesis,15084127,J. Med. Chem.,2004,47,9,2283,267.24,-1.81,134.99,0,Active
CHEMBL195802,OC(=O)\C(=C\c1ccc(Oc2ccccc2Br)cc1)\NC(=O)CCc3ccc(F)cc3,IC50,=,600,nM,6.22184875,Q8JXU8,Hepatitis C virus NS5B RNA-dependent RNA polymerase,CHEMBL1145278,Scientific Literature,Inhibitory concentration against RNA dependent RNA polymerase Nonstructural protein 5B (HCV NS5B polymerase) in Hepatitis C virus,15911260,Bioorg. Med. Chem. Lett.,2005,15,11,2812,484.31,5.42,75.63,1,Active
CHEMBL202498,Cc1ccc(cc1)S(=O)(=O)NN2C(O)\C(=C\c3ccc(Cl)c(Cl)c3)\SC2=S,IC50,=,600,nM,6.22184875,Q8JXU8,Hepatitis C virus NS5B RNA-dependent RNA polymerase,CHEMBL1149391,Scientific Literature,Inhibitory activity against HCV delta 21 NS5b RNA polymerase,16451069,J. Med. Chem.,2006,49,3,1034,461.41,5.32,135.41,1,Active
CHEMBL201236,C\C(=C/1\SC(=S)N(NS(=O)(=O)c2ccccc2)C1=O)\c3ccc(Cl)c(Cl)c3,IC50,=,600,nM,6.22184875,Q8JXU8,Hepatitis C virus NS5B RNA-dependent RNA polymerase,CHEMBL1149391,Scientific Literature,Inhibitory activity against HCV delta 21 NS5b RNA polymerase,16451069,J. Med. Chem.,2006,49,3,1034,459.39,5.36,132.25,1,Active
CHEMBL379470,OC(=O)c1nc(nc(O)c1O)c2sccc2NC(=O)NCCc3ccccc3,IC50,=,620,nM,6.207608311,Q8JXU8,Hepatitis C virus NS5B RNA-dependent RNA polymerase,CHEMBL1138187,Scientific Literature,Inhibitory activity against HCV 1b BK NS5B deltaC55 RNA polymerase,16509585,J. Med. Chem.,2006,49,5,1693,400.41,2.76,172.91,0,Active
CHEMBL363563,OC(=O)\C(=C\c1ccc(s1)c2ccccc2Cl)\NC(=O)c3ccccc3,IC50,=,660,nM,6.180456064,Q8JXU8,Hepatitis C virus NS5B RNA-dependent RNA polymerase,CHEMBL1140265,Scientific Literature,Inhibitory concentration against Hepatitis C virus NS5B polymerase,15863301,Bioorg. Med. Chem. Lett.,2005,15,10,2481,383.85,4.84,94.64,0,Active
CHEMBL369909,OC(=O)C(=O)\C=C(/O)\c1cccc(OCc2cccc3ccccc23)c1,IC50,=,670,nM,6.173925197,Q8JXU8,Hepatitis C virus NS5B RNA-dependent RNA polymerase,CHEMBL1140440,Scientific Literature,"Inhibitory concentration against NS5B HCV polymerase using [alpha-32P]UTP as radioligand (30 degree C for 2 h, at pH 7.5 with Tris-HCl buffer)",16190757,J. Med. Chem.,2005,48,20,6304,348.35,3.74,83.83,0,Active
CHEMBL439511,CC(C)(C)C(=O)CN1C(=O)C(=C(O)c2cc(F)ccc12)C3=NS(=O)(=O)c4ccccc4N3,IC50,=,696,nM,6.15739076,Q8JXU8,Hepatitis C virus NS5B RNA-dependent RNA polymerase,CHEMBL1148625,Scientific Literature,Inhibitory activity against HCV delta 21 NS5B RNA polymerase by SPA assay,16451063,J. Med. Chem.,2006,49,3,971,457.47,1.94,124.51,0,Active
CHEMBL200965,Brc1ccc(\C=C\2/SC(=S)N(NS(=O)(=O)c3ccccc3)C2=O)cc1,IC50,=,700,nM,6.15490196,Q8JXU8,Hepatitis C virus NS5B RNA-dependent RNA polymerase,CHEMBL1149391,Scientific Literature,Inhibitory activity against HCV delta 21 NS5b RNA polymerase,16451069,J. Med. Chem.,2006,49,3,1034,455.37,4.33,132.25,0,Active
CHEMBL382093,CCOC(=O)c1c2CCCCc2sc1NC(=O)NS(=O)(=O)c3cccc4ccccc34,IC50,=,700,nM,6.15490196,Q8JXU8,Hepatitis C virus NS5B RNA-dependent RNA polymerase,CHEMBL1148540,Scientific Literature,Inhibitory activity against HCV 4a NS5B full length RNA dependent RNA polymerase,16260131,Bioorg. Med. Chem. Lett.,2006,16,1,100,458.55,4.38,138.18,0,Active
CHEMBL23458,OC(=O)[C@H](Cc1ccccc1)N(Cc2cccc(c2)[N+](=O)[O-])C(=O)c3ccc(Cl)cc3Cl,IC50,=,700,nM,6.15490196,Q8JXU8,Hepatitis C virus NS5B RNA-dependent RNA polymerase,CHEMBL1144916,Scientific Literature,Inhibitory activity against Hepatitis C RNA dependent RNA polymerase Nonstructural protein 5B (NS5B polymerase) expressed from baculovirus-infected Sf9 insect cells,12672227,J. Med. Chem.,2003,46,8,1283,473.31,5.57,103.43,1,Active
CHEMBL371696,CCOC(=O)c1c2CCCCc2sc1NC(=O)NS(=O)(=O)c3ccccc3,IC50,=,700,nM,6.15490196,Q8JXU8,Hepatitis C virus NS5B RNA-dependent RNA polymerase,CHEMBL1148540,Scientific Literature,Inhibitory activity against HCV 4a NS5B full length RNA dependent RNA polymerase,16260131,Bioorg. Med. Chem. Lett.,2006,16,1,100,408.49,3.47,138.18,0,Active
CHEMBL367243,OC(=O)[C@@H](Cc1c[nH]c2ccc(O)cc12)NC(=O)c3ccc4c(c3)nc(c5cocc5)n4C6CCCCC6,IC50,=,700,nM,6.15490196,Q8JXU8,Hepatitis C virus NS5B RNA-dependent RNA polymerase,CHEMBL1149207,Scientific Literature,Concentration required for inhibiting hepatitis C virus NS5B RNA polymerase activity.,15013003,Bioorg. Med. Chem. Lett.,2004,14,4,967,512.56,5.22,133.38,2,Active
CHEMBL360543,CC(C)C[C@]1(C[C@@H]([C@@H](N1C(=O)c2ccc(cc2)C(F)(F)F)c3ccccn3)C(=O)O)C(=O)O,IC50,=,700,nM,6.15490196,Q8JXU8,Hepatitis C virus NS5B RNA-dependent RNA polymerase,CHEMBL1142030,Scientific Literature,Inhibitory concentration against Hepatitis C virus RNA dependent RNA polymerase Nonstructural protein 5B,15745795,Bioorg. Med. Chem. Lett.,2005,15,6,1553,464.43,3.91,107.8,0,Active
CHEMBL264217,OC1N(NS(=O)(=O)c2ccc(F)cc2)C(=S)S/C/1=C\c3ccc(Cl)c(Cl)c3,IC50,=,700,nM,6.15490196,Q8JXU8,Hepatitis C virus NS5B RNA-dependent RNA polymerase,CHEMBL1149391,Scientific Literature,Inhibitory activity against HCV delta 21 NS5b RNA polymerase,16451069,J. Med. Chem.,2006,49,3,1034,465.37,5.04,135.41,1,Active
CHEMBL180771,CC(C)C[C@]1(C[C@@H]([C@@H](N1C(=O)c2cccc3ccccc23)c4cccs4)C(=O)O)C(=O)O,IC50,=,700,nM,6.15490196,Q8JXU8,Hepatitis C virus NS5B RNA-dependent RNA polymerase,CHEMBL1142030,Scientific Literature,Inhibitory concentration against Hepatitis C virus RNA dependent RNA polymerase Nonstructural protein 5B,15745795,Bioorg. Med. Chem. Lett.,2005,15,6,1553,451.53,4.55,123.15,0,Active
CHEMBL180188,CC(C)C[C@]1(C[C@@H]([C@@H](N1C(=O)c2ccc(cc2)C(F)(F)F)c3ccccc3)C(=O)O)C(=O)O,IC50,=,700,nM,6.15490196,Q8JXU8,Hepatitis C virus NS5B RNA-dependent RNA polymerase,CHEMBL1142030,Scientific Literature,Inhibitory concentration against Hepatitis C virus RNA dependent RNA polymerase Nonstructural protein 5B,15745795,Bioorg. Med. Chem. Lett.,2005,15,6,1553,463.45,4.74,94.91,0,Active
CHEMBL202934,CCCCS(=O)(=O)NN1C(=S)S\C(=C/c2ccc(Cl)c(Cl)c2)\C1=O,IC50,=,700,nM,6.15490196,Q8JXU8,Hepatitis C virus NS5B RNA-dependent RNA polymerase,CHEMBL1149391,Scientific Literature,Inhibitory activity against HCV delta 21 NS5b RNA polymerase,16451069,J. Med. Chem.,2006,49,3,1034,425.37,4.66,132.25,0,Active
CHEMBL201681,CCCCC1(CC(=O)O)OCCc2c1sc3c(Cl)ccc(Cl)c23,IC50,=,750,nM,6.124938737,Q8JXU8,Hepatitis C virus NS5B RNA-dependent RNA polymerase,CHEMBL1148590,Scientific Literature,Displacement of [alpha-32P]GTP from recombinant HCV NS5B RNA dependent RNA polymerase,16274990,Bioorg. Med. Chem. Lett.,2006,16,2,457,373.29,5.59,74.77,1,Active
CHEMBL427375,OC1=C(C(=O)N(CCCCC#N)c2ccccc12)C3=NS(=O)(=O)c4ccccc4N3,IC50,=,750,nM,6.124938737,Q8JXU8,Hepatitis C virus NS5B RNA-dependent RNA polymerase,CHEMBL1148625,Scientific Literature,Inhibitory activity against HCV delta 21 NS5B RNA polymerase by SPA assay,16451063,J. Med. Chem.,2006,49,3,971,422.46,1.36,131.23,0,Active
CHEMBL207979,OC(=O)[C@@H]1CCCN1S(=O)(=O)c2cc(Cl)cc(Cl)c2O,IC50,=,770,nM,6.113509275,Q8JXU8,Hepatitis C virus NS5B RNA-dependent RNA polymerase,CHEMBL1147722,Scientific Literature,Inhibition of HCV NS5B RNA dependent RNA polymerase,16722622,J. Med. Chem.,2006,49,11,3052,340.18,2.11,103.29,0,Active
CHEMBL202191,OC1=C(C2=NS(=O)(=O)c3ccccc3N2)C(=O)N(Cc4ccccc4C#N)c5ccccc15,IC50,=,780,nM,6.107905397,Q8JXU8,Hepatitis C virus NS5B RNA-dependent RNA polymerase,CHEMBL1148625,Scientific Literature,Inhibitory activity against HCV delta 21 NS5B RNA polymerase by SPA assay,16451063,J. Med. Chem.,2006,49,3,971,456.47,2.06,131.23,0,Active
CHEMBL365977,OC(=O)CCC(=O)N\C(=C/c1ccc(Oc2ccccc2I)cc1)\C(=O)O,IC50,=,790,nM,6.102372909,Q8JXU8,Hepatitis C virus NS5B RNA-dependent RNA polymerase,CHEMBL1145278,Scientific Literature,Inhibitory concentration against RNA dependent RNA polymerase Nonstructural protein 5B (HCV NS5B polymerase) in Hepatitis C virus,15911260,Bioorg. Med. Chem. Lett.,2005,15,11,2812,481.24,2.74,112.93,0,Active
CHEMBL212390,CCOc1ccc(CCC2(CC(=O)CC(=O)O2)C3CCCC3)cc1F,IC50,=,790,nM,6.102372909,Q8JXU8,Hepatitis C virus NS5B RNA-dependent RNA polymerase,CHEMBL1149470,Scientific Literature,Inhibitory activity against HCV 1b BK NS5B deltaC21 RNA polymerase,16824756,Bioorg. Med. Chem. Lett.,2006,16,18,4834,348.41,4.38,52.6,0,Active
CHEMBL179508,CC(C)C[C@]1(C[C@@H]([C@@H](N1C(=O)c2ccc(cc2)C(F)(F)F)c3occc3)C(=O)O)C(=O)O,IC50,=,800,nM,6.096910013,Q8JXU8,Hepatitis C virus NS5B RNA-dependent RNA polymerase,CHEMBL1142030,Scientific Literature,Inhibitory concentration against Hepatitis C virus RNA dependent RNA polymerase Nonstructural protein 5B,15745795,Bioorg. Med. Chem. Lett.,2005,15,6,1553,453.41,4.03,108.05,0,Active
CHEMBL25773,OC(=O)[C@H](Cc1ccccc1)N(Cc2cccc(c2)C#N)C(=O)c3ccc(Cl)cc3Cl,IC50,=,800,nM,6.096910013,Q8JXU8,Hepatitis C virus NS5B RNA-dependent RNA polymerase,CHEMBL1144916,Scientific Literature,Inhibitory activity against Hepatitis C RNA dependent RNA polymerase Nonstructural protein 5B (NS5B polymerase) expressed from baculovirus-infected Sf9 insect cells,12672227,J. Med. Chem.,2003,46,8,1283,453.32,5.56,81.4,1,Active
CHEMBL383513,OC(=O)c1ccc2c(c1)nc(c3ccc(OCCCc4ccccc4)cc3)n2C5CCCCC5,IC50,=,800,nM,6.096910013,Q8JXU8,Hepatitis C virus NS5B RNA-dependent RNA polymerase,CHEMBL1146135,Scientific Literature,Inhibitory activity against HCV 1b NS5B RNA dependent RNA polymerase,16455252,Bioorg. Med. Chem. Lett.,2006,16,7,1859,454.56,7.31,64.35,1,Active
CHEMBL202032,COc1cccc(c1)S(=O)(=O)NN2C(O)\C(=C\c3ccc(Cl)c(Cl)c3)\SC2=S,IC50,=,800,nM,6.096910013,Q8JXU8,Hepatitis C virus NS5B RNA-dependent RNA polymerase,CHEMBL1149391,Scientific Literature,Inhibitory activity against HCV delta 21 NS5b RNA polymerase,16451069,J. Med. Chem.,2006,49,3,1034,477.41,4.81,144.63,0,Active
CHEMBL195149,CONC(=O)\C(=C\c1ccc(Oc2ccccc2Br)cc1)\NC(=O)c3ccccc3,IC50,=,800,nM,6.096910013,Q8JXU8,Hepatitis C virus NS5B RNA-dependent RNA polymerase,CHEMBL1145278,Scientific Literature,Inhibitory concentration against RNA dependent RNA polymerase Nonstructural protein 5B (HCV NS5B polymerase) in Hepatitis C virus,15911260,Bioorg. Med. Chem. Lett.,2005,15,11,2812,467.31,4.15,76.66,0,Active
CHEMBL206569,OC(=O)c1nc(nc(O)c1O)c2sccc2NC(=O)c3ccccc3,IC50,=,800,nM,6.096910013,Q8JXU8,Hepatitis C virus NS5B RNA-dependent RNA polymerase,CHEMBL1138187,Scientific Literature,Inhibitory activity against HCV 1b BK NS5B deltaC55 RNA polymerase,16509585,J. Med. Chem.,2006,49,5,1693,357.34,2.52,160.88,0,Active
CHEMBL202079,COCCN1C(=O)C(=C(O)c2ccccc12)C3=NS(=O)(=O)c4ccccc4N3,IC50,=,819,nM,6.086716098,Q8JXU8,Hepatitis C virus NS5B RNA-dependent RNA polymerase,CHEMBL1148625,Scientific Literature,Inhibitory activity against HCV delta 21 NS5B RNA polymerase by SPA assay,16451063,J. Med. Chem.,2006,49,3,971,399.42,0.47,116.68,0,Active
CHEMBL426088,OC(=O)\C(=C\c1ccc(Oc2ccccc2Br)cc1)\NC(=O)Cc3ccc(Br)cc3,IC50,=,820,nM,6.086186148,Q8JXU8,Hepatitis C virus NS5B RNA-dependent RNA polymerase,CHEMBL1145278,Scientific Literature,Inhibitory concentration against RNA dependent RNA polymerase Nonstructural protein 5B (HCV NS5B polymerase) in Hepatitis C virus,15911260,Bioorg. Med. Chem. Lett.,2005,15,11,2812,531.19,5.51,75.63,2,Active
CHEMBL387310,Cc1c(c2ccccn2)n(C3CCCCC3)c4ccc(cc14)C(=O)O,IC50,=,820,nM,6.086186148,Q8JXU8,Hepatitis C virus NS5B RNA-dependent RNA polymerase,CHEMBL1146881,Scientific Literature,Inhibition of HCV 1b NS5B delta21 RNA dependent RNA polymerase by SPA,16908138,Bioorg. Med. Chem. Lett.,2006,16,19,4987,334.41,5.39,55.12,1,Active
CHEMBL194448,OC(=O)CCCC(=O)N\C(=C/c1ccc(Oc2ccccc2I)cc1)\C(=O)O,IC50,=,830,nM,6.080921908,Q8JXU8,Hepatitis C virus NS5B RNA-dependent RNA polymerase,CHEMBL1145278,Scientific Literature,Inhibitory concentration against RNA dependent RNA polymerase Nonstructural protein 5B (HCV NS5B polymerase) in Hepatitis C virus,15911260,Bioorg. Med. Chem. Lett.,2005,15,11,2812,495.26,3.19,112.93,0,Active
CHEMBL193835,OC(=O)\C(=C\c1ccc(Oc2ccccc2Br)cc1)\NC(=O)CC3CCCC3,IC50,=,850,nM,6.070581074,Q8JXU8,Hepatitis C virus NS5B RNA-dependent RNA polymerase,CHEMBL1145278,Scientific Literature,Inhibitory concentration against RNA dependent RNA polymerase Nonstructural protein 5B (HCV NS5B polymerase) in Hepatitis C virus,15911260,Bioorg. Med. Chem. Lett.,2005,15,11,2812,444.32,4.98,75.63,0,Active
CHEMBL215736,COc1ccc(CCC2(CC(=O)CC(=O)O2)C3CCCC3)cc1F,IC50,=,890,nM,6.050609993,Q8JXU8,Hepatitis C virus NS5B RNA-dependent RNA polymerase,CHEMBL1149470,Scientific Literature,Inhibitory activity against HCV 1b BK NS5B deltaC21 RNA polymerase,16824756,Bioorg. Med. Chem. Lett.,2006,16,18,4834,334.38,4.03,52.6,0,Active
CHEMBL202264,O=C1N(NS(=O)(=O)c2ccccc2)C(=S)S/C/1=C\c3ccc(cc3)C#N,IC50,=,900,nM,6.045757491,Q8JXU8,Hepatitis C virus NS5B RNA-dependent RNA polymerase,CHEMBL1149391,Scientific Literature,Inhibitory activity against HCV delta 21 NS5b RNA polymerase,16451069,J. Med. Chem.,2006,49,3,1034,401.48,3.46,156.04,0,Active
CHEMBL183364,COc1ccc2c(cccc2c1C(F)(F)F)C(=O)N(CC(=O)O)CC(=O)O,IC50,=,900,nM,6.045757491,Q8JXU8,Hepatitis C virus NS5B RNA-dependent RNA polymerase,CHEMBL1137155,Scientific Literature,Inhibitory concentration against HCV NS5B RNA dependent RNA polymerase,15261274,Bioorg. Med. Chem. Lett.,2004,14,16,4221,385.29,2.04,104.14,0,Active
CHEMBL413358,CC(C)C[C@]1(C[C@@H]([C@@H](N1C(=O)c2ccc(cc2)C(F)(F)F)c3ccc(Cl)cc3)C(=O)O)C(=O)O,IC50,=,900,nM,6.045757491,Q8JXU8,Hepatitis C virus NS5B RNA-dependent RNA polymerase,CHEMBL1142030,Scientific Literature,Inhibitory concentration against Hepatitis C virus RNA dependent RNA polymerase Nonstructural protein 5B,15745795,Bioorg. Med. Chem. Lett.,2005,15,6,1553,497.89,5.4,94.91,1,Active
CHEMBL369958,CCOC(=O)c1c2CCCCc2sc1NC(=O)NS(=O)(=O)c3cccc(C)c3,IC50,=,900,nM,6.045757491,Q8JXU8,Hepatitis C virus NS5B RNA-dependent RNA polymerase,CHEMBL1148540,Scientific Literature,Inhibitory activity against HCV 4a NS5B full length RNA dependent RNA polymerase,16260131,Bioorg. Med. Chem. Lett.,2006,16,1,100,422.52,3.96,138.18,0,Active
CHEMBL382327,CCOC(=O)c1c2CCCCc2sc1NC(=O)NS(=O)(=O)c3ccccc3C,IC50,=,900,nM,6.045757491,Q8JXU8,Hepatitis C virus NS5B RNA-dependent RNA polymerase,CHEMBL1148540,Scientific Literature,Inhibitory activity against HCV 4a NS5B full length RNA dependent RNA polymerase,16260131,Bioorg. Med. Chem. Lett.,2006,16,1,100,422.52,3.96,138.18,0,Active
CHEMBL361657,COc1ccc2c(C(=O)NC(CC(=O)O)C(=O)O)c(Br)ccc2c1C(F)(F)F,IC50,=,910,nM,6.040958608,Q8JXU8,Hepatitis C virus NS5B RNA-dependent RNA polymerase,CHEMBL1137155,Scientific Literature,Inhibitory concentration against HCV NS5B RNA dependent RNA polymerase,15261274,Bioorg. Med. Chem. Lett.,2004,14,16,4221,464.19,2.97,112.93,0,Active
CHEMBL363846,CN(C)Cc1ccc(cc1)c2c(C3CCCCC3)c4ccc(cc4n2CC(=O)N(C)C)C(=O)O,IC50,=,920,nM,6.036212173,Q8JXU8,Hepatitis C virus NS5B RNA-dependent RNA polymerase,CHEMBL1140313,Scientific Literature,Inhibitory activity against by hepatitis C virus NS5B polymerase,15999993,J. Med. Chem.,2005,48,14,4547,461.6,2.26,65.78,0,Active
CHEMBL384679,OC(=O)c1ccc2c(c1)nc(c3ccc(OCc4ccccc4c5ccccc5)cc3C(F)(F)F)n2C6CCCCC6,IC50,=,930,nM,6.031517051,Q8JXU8,Hepatitis C virus NS5B RNA-dependent RNA polymerase,CHEMBL1138950,Scientific Literature,Inhibition of HCV 1b BK six His-tagged C-terminal truncated 544 amino acid NS5B RNA dependent RNA polymerase,16854079,J. Med. Chem.,2006,49,15,4721,570.6,8.99,64.35,2,Active
CHEMBL427171,OC(=O)\C(=C\c1ccc(Oc2ccccc2Br)cc1)\NC(=O)Cc3ccc(Cl)cc3,IC50,=,940,nM,6.026872146,Q8JXU8,Hepatitis C virus NS5B RNA-dependent RNA polymerase,CHEMBL1145278,Scientific Literature,Inhibitory concentration against RNA dependent RNA polymerase Nonstructural protein 5B (HCV NS5B polymerase) in Hepatitis C virus,15911260,Bioorg. Med. Chem. Lett.,2005,15,11,2812,486.74,5.42,75.63,1,Active
CHEMBL372359,OC(=O)C(=O)\C=C(/O)\c1cccc(OCc2ccsc2C(=O)O)c1,IC50,=,950,nM,6.022276395,Q8JXU8,Hepatitis C virus NS5B RNA-dependent RNA polymerase,CHEMBL1140440,Scientific Literature,"Inhibitory concentration against NS5B HCV polymerase using [alpha-32P]UTP as radioligand (30 degree C for 2 h, at pH 7.5 with Tris-HCl buffer)",16190757,J. Med. Chem.,2005,48,20,6304,348.33,2.42,149.36,0,Active
CHEMBL439333,CC(C)CCN1C(=O)C(=C(O)c2cc(NC(=O)C3CCCC3)ccc12)C4=NS(=O)(=O)c5ccccc5N4,IC50,=,973,nM,6.01188716,Q8JXU8,Hepatitis C virus NS5B RNA-dependent RNA polymerase,CHEMBL1148625,Scientific Literature,Inhibitory activity against HCV delta 21 NS5B RNA polymerase by SPA assay,16451063,J. Med. Chem.,2006,49,3,971,522.62,2.97,136.54,1,Active
CHEMBL206624,OC(=O)c1ccc2c(c1)nc(c3ccc(OCC(c4ccccc4)c5ccccc5)cc3)n2C6CCCCC6,IC50,=,980,nM,6.008773924,Q8JXU8,Hepatitis C virus NS5B RNA-dependent RNA polymerase,CHEMBL1146135,Scientific Literature,Inhibitory activity against HCV 1b NS5B RNA dependent RNA polymerase,16455252,Bioorg. Med. Chem. Lett.,2006,16,7,1859,516.63,8.2,64.35,2,Active
CHEMBL26052,OC(=O)[C@H](Cc1ccccc1)N(Cc2cccc(Br)c2)C(=O)c3ccc(Cl)cc3,IC50,=,11000,nM,4.958607315,Q8JXU8,Hepatitis C virus NS5B RNA-dependent RNA polymerase,CHEMBL1144916,Scientific Literature,Inhibitory activity against Hepatitis C RNA dependent RNA polymerase Nonstructural protein 5B (NS5B polymerase) expressed from baculovirus-infected Sf9 insect cells,12672227,J. Med. Chem.,2003,46,8,1283,472.76,5.76,57.61,1,Inactive
CHEMBL425915,OC(=O)\C(=C\c1cccc(n1)c2ccccc2Cl)\NC(=O)c3ccccc3,IC50,=,11000,nM,4.958607315,Q8JXU8,Hepatitis C virus NS5B RNA-dependent RNA polymerase,CHEMBL1140265,Scientific Literature,Inhibitory concentration against Hepatitis C virus NS5B polymerase,15863301,Bioorg. Med. Chem. Lett.,2005,15,10,2481,378.81,4.31,79.29,0,Inactive
CHEMBL381166,Cc1ccc(C#N)c2c3CCC(CC=C)(C(=O)O)c3[nH]c12,IC50,=,11000,nM,4.958607315,Q8JXU8,Hepatitis C virus NS5B RNA-dependent RNA polymerase,CHEMBL1147645,Scientific Literature,Inhibition of HCV 1b BK NS5B RNA polymerase,16480869,Bioorg. Med. Chem. Lett.,2006,16,9,2532,280.32,3.96,76.88,0,Inactive
CHEMBL283833,OC(=O)[C@H](Cc1ccccc1)N(Cc2cccnc2)C(=O)c3ccc(Cl)cc3Cl,IC50,=,11000,nM,4.958607315,Q8JXU8,Hepatitis C virus NS5B RNA-dependent RNA polymerase,CHEMBL1144916,Scientific Literature,Inhibitory activity against Hepatitis C RNA dependent RNA polymerase Nonstructural protein 5B (NS5B polymerase) expressed from baculovirus-infected Sf9 insect cells,12672227,J. Med. Chem.,2003,46,8,1283,429.3,4.53,70.5,0,Inactive
CHEMBL366966,OC(=O)C(=O)CC(=O)c1cccc(NC(=O)c2ccccc2)c1,IC50,=,11000,nM,4.958607315,Q8JXU8,Hepatitis C virus NS5B RNA-dependent RNA polymerase,CHEMBL1139456,Scientific Literature,Inhibitory activity against Hepatitis C virus RNA dependent RNA polymerase nonstructural protein 5B,14695815,J. Med. Chem.,2004,47,1,14,311.29,2.04,100.54,0,Inactive
CHEMBL372777,Clc1ccc(CC2SC(=S)N(NS(=O)(=O)c3ccccc3)C2=O)cc1Cl,IC50,=,11000,nM,4.958607315,Q8JXU8,Hepatitis C virus NS5B RNA-dependent RNA polymerase,CHEMBL1149391,Scientific Literature,Inhibitory activity against HCV delta 21 NS5b RNA polymerase,16451069,J. Med. Chem.,2006,49,3,1034,447.38,5.06,132.25,1,Inactive
CHEMBL213078,COc1ccc(cc1)c2nc3cc(ccc3n2C4CCCCC4)C(=O)O,IC50,=,11200,nM,4.950781977,Q8JXU8,Hepatitis C virus NS5B RNA-dependent RNA polymerase,CHEMBL1146030,Scientific Literature,Inhibition of HCV BK NS5B deltaC55 RNA dependent RNA polymerase,16714108,Bioorg. Med. Chem. Lett.,2006,16,15,4026,350.41,4.95,64.34,0,Inactive
CHEMBL83762,COC(=O)N(CC(=O)O)C(=O)c1c(OC)ccc2c(c(OC)ccc12)C(F)(F)F,IC50,=,11300,nM,4.946921557,Q8JXU8,Hepatitis C virus NS5B RNA-dependent RNA polymerase,CHEMBL1137155,Scientific Literature,Inhibitory concentration against HCV NS5B RNA dependent RNA polymerase,15261274,Bioorg. Med. Chem. Lett.,2004,14,16,4221,415.32,2.97,102.37,0,Inactive
CHEMBL361428,CC(C)C[C@]1(C[C@@H]([C@@H](N1C(=O)c2ccccc2)c3cccs3)C(=O)O)C(=O)O,IC50,=,11400,nM,4.943095149,Q8JXU8,Hepatitis C virus NS5B RNA-dependent RNA polymerase,CHEMBL1142030,Scientific Literature,Inhibitory concentration against Hepatitis C virus RNA dependent RNA polymerase Nonstructural protein 5B,15745795,Bioorg. Med. Chem. Lett.,2005,15,6,1553,401.48,3.64,123.15,0,Inactive
CHEMBL203738,OC(=O)c1nc(nc(O)c1O)c2cc3ccccc3s2,IC50,=,11600,nM,4.935542011,Q8JXU8,Hepatitis C virus NS5B RNA-dependent RNA polymerase,CHEMBL1138187,Scientific Literature,Inhibitory activity against HCV 1b BK NS5B deltaC55 RNA polymerase,16509585,J. Med. Chem.,2006,49,5,1693,288.28,2.94,131.78,0,Inactive
CHEMBL193596,Oc1ccc(NC(=O)\C(=C\c2ccc(Oc3ccccc3Br)cc2)\NC(=O)c4ccccc4)cc1,IC50,=,12000,nM,4.920818754,Q8JXU8,Hepatitis C virus NS5B RNA-dependent RNA polymerase,CHEMBL1145278,Scientific Literature,Inhibitory concentration against RNA dependent RNA polymerase Nonstructural protein 5B (HCV NS5B polymerase) in Hepatitis C virus,15911260,Bioorg. Med. Chem. Lett.,2005,15,11,2812,529.38,5.64,87.66,2,Inactive
CHEMBL370131,Cc1cccc(c1)\C(=C\C(=O)C(=O)O)\O,IC50,=,12000,nM,4.920818754,Q8JXU8,Hepatitis C virus NS5B RNA-dependent RNA polymerase,CHEMBL1140440,Scientific Literature,"Inhibitory concentration against NS5B HCV polymerase using [alpha-32P]UTP as radioligand (30 degree C for 2 h, at pH 7.5 with Tris-HCl buffer)",16190757,J. Med. Chem.,2005,48,20,6304,206.19,1.75,74.59,0,Inactive
CHEMBL173638,COc1ccc(cc1OC)[C@H](C)NC(=O)c2ccc3c(c2)nc(c4ccccn4)n3C5CCCCC5,IC50,=,12000,nM,4.920818754,Q8JXU8,Hepatitis C virus NS5B RNA-dependent RNA polymerase,CHEMBL1149207,Scientific Literature,Concentration required for inhibiting hepatitis C virus NS5B RNA polymerase activity.,15013003,Bioorg. Med. Chem. Lett.,2004,14,4,967,484.59,5.75,78.27,1,Inactive
CHEMBL371388,OC(=O)\C(=C\c1oc(cc1)c2ccc(F)cc2)\NC(=O)c3ccccc3,IC50,=,12000,nM,4.920818754,Q8JXU8,Hepatitis C virus NS5B RNA-dependent RNA polymerase,CHEMBL1140265,Scientific Literature,Inhibitory concentration against Hepatitis C virus NS5B polymerase,15863301,Bioorg. Med. Chem. Lett.,2005,15,10,2481,351.33,3.83,79.54,0,Inactive
CHEMBL180457,OC(=O)[C@H]1C[C@H](N(C1)C(=O)c2ccc(Cl)c(Cl)c2)C(=O)O,IC50,=,12000,nM,4.920818754,Q8JXU8,Hepatitis C virus NS5B RNA-dependent RNA polymerase,CHEMBL1142030,Scientific Literature,Inhibitory concentration against Hepatitis C virus RNA dependent RNA polymerase Nonstructural protein 5B,15745795,Bioorg. Med. Chem. Lett.,2005,15,6,1553,332.14,1.97,94.91,0,Inactive
CHEMBL178076,COc1ccc(CCNC(=O)c2ccc3c(c2)nc(c4ccccn4)n3C5CCCCC5)cc1OC,IC50,=,12000,nM,4.920818754,Q8JXU8,Hepatitis C virus NS5B RNA-dependent RNA polymerase,CHEMBL1149223,Scientific Literature,Inhibitory activity against NS5B polymerase of hepatitis C virus,14684311,Bioorg. Med. Chem. Lett.,2004,14,1,119,484.59,5.69,78.27,1,Inactive
CHEMBL368626,OC(=O)c1ccc2c(c1)nc(c3ccccn3)n2C4CCCC4,IC50,=,12000,nM,4.920818754,Q8JXU8,Hepatitis C virus NS5B RNA-dependent RNA polymerase,CHEMBL1149223,Scientific Literature,Inhibitory activity against NS5B polymerase of hepatitis C virus,14684311,Bioorg. Med. Chem. Lett.,2004,14,1,119,307.35,3.79,68.01,0,Inactive
CHEMBL177302,CN(C)CCCNC(=O)COc1ccc(cc1)c2nc3cc(ccc3n2C4CCCCC4)C(=O)O,IC50,=,13000,nM,4.886056648,Q8JXU8,Hepatitis C virus NS5B RNA-dependent RNA polymerase,CHEMBL1149223,Scientific Literature,Inhibitory activity against NS5B polymerase of hepatitis C virus,14684311,Bioorg. Med. Chem. Lett.,2004,14,1,119,478.58,1.17,96.69,0,Inactive
CHEMBL183402,Fc1ccc(cc1)c2nc3ncnc(NCCc4ccccc4)c3nc2c5ccc(F)cc5,IC50,=,13000,nM,4.886056648,Q8JXU8,Hepatitis C virus NS5B RNA-dependent RNA polymerase,CHEMBL1144286,Scientific Literature,Inhibitory concentration against RNA dependent RNA polymerase Nonstructural protein 5B of hepatitis C virus,15664835,Bioorg. Med. Chem. Lett.,2005,15,3,675,439.46,6.27,63.59,1,Inactive
CHEMBL425017,OC(=O)\C(=C\c1oc(cc1)c2ccc(cc2)C(F)(F)F)\NC(=O)c3ccccc3,IC50,=,13000,nM,4.886056648,Q8JXU8,Hepatitis C virus NS5B RNA-dependent RNA polymerase,CHEMBL1140265,Scientific Literature,Inhibitory concentration against Hepatitis C virus NS5B polymerase,15863301,Bioorg. Med. Chem. Lett.,2005,15,10,2481,401.34,4.56,79.54,0,Inactive
CHEMBL194466,OC(=O)C(=O)\C=C(/O)\c1cccn1Cc2ccc3ccccc3c2,IC50,=,13000,nM,4.886056648,Q8JXU8,Hepatitis C virus NS5B RNA-dependent RNA polymerase,CHEMBL1140440,Scientific Literature,"Inhibitory concentration against NS5B HCV polymerase using [alpha-32P]UTP as radioligand (30 degree C for 2 h, at pH 7.5 with Tris-HCl buffer)",16190757,J. Med. Chem.,2005,48,20,6304,321.33,3.35,79.53,0,Inactive
CHEMBL370124,OC(=O)C(=O)\C=C(/O)\c1cccn1CCCCC#N,IC50,=,13000,nM,4.886056648,Q8JXU8,Hepatitis C virus NS5B RNA-dependent RNA polymerase,CHEMBL1140440,Scientific Literature,"Inhibitory concentration against NS5B HCV polymerase using [alpha-32P]UTP as radioligand (30 degree C for 2 h, at pH 7.5 with Tris-HCl buffer)",16190757,J. Med. Chem.,2005,48,20,6304,262.26,1.61,103.32,0,Inactive
CHEMBL199195,OC(=O)C(=O)\C=C(/O)\c1cccn1Cc2ccc(O)cc2,IC50,=,13000,nM,4.886056648,Q8JXU8,Hepatitis C virus NS5B RNA-dependent RNA polymerase,CHEMBL1140440,Scientific Literature,"Inhibitory concentration against NS5B HCV polymerase using [alpha-32P]UTP as radioligand (30 degree C for 2 h, at pH 7.5 with Tris-HCl buffer)",16190757,J. Med. Chem.,2005,48,20,6304,287.27,2.2,99.76,0,Inactive
CHEMBL181724,OC(=O)c1cnc(s1)N(C2CCSCC2)C(=O)c3ccc(Oc4ccccc4)cc3,IC50,=,13000,nM,4.886056648,Q8JXU8,Hepatitis C virus NS5B RNA-dependent RNA polymerase,CHEMBL1144458,Scientific Literature,Inhibitory concentration against RNA dependent RNA polymerase nonstructural protein 5B of hepatitis C virus,15582422,Bioorg. Med. Chem. Lett.,2005,15,1,115,440.54,3.89,133.27,0,Inactive
CHEMBL371601,OC(=O)\C(=C\c1ccc(Oc2ccccc2Br)cc1)\NC(=O)CCC3CCCCC3,IC50,=,13000,nM,4.886056648,Q8JXU8,Hepatitis C virus NS5B RNA-dependent RNA polymerase,CHEMBL1145278,Scientific Literature,Inhibitory concentration against RNA dependent RNA polymerase Nonstructural protein 5B (HCV NS5B polymerase) in Hepatitis C virus,15911260,Bioorg. Med. Chem. Lett.,2005,15,11,2812,472.37,5.89,75.63,1,Inactive
CHEMBL174542,CC1CCCCC1n2c(nc3cc(ccc23)C(=O)O)c4ccccn4,IC50,=,13000,nM,4.886056648,Q8JXU8,Hepatitis C virus NS5B RNA-dependent RNA polymerase,CHEMBL1149223,Scientific Literature,Inhibitory activity against NS5B polymerase of hepatitis C virus,14684311,Bioorg. Med. Chem. Lett.,2004,14,1,119,335.4,4.56,68.01,0,Inactive
CHEMBL180404,CCC(CC)N1C(=O)C(=C(O)c2cccnc12)C3=NS(=O)(=O)c4ccccc4N3,IC50,=,13200,nM,4.879426069,Q8JXU8,Hepatitis C virus NS5B RNA-dependent RNA polymerase,CHEMBL1142034,Scientific Literature,Inhibitory concentration against RNA dependent RNA polymerase Nonstructural protein 5B of genotype 1b Hepatitis C virus,15745800,Bioorg. Med. Chem. Lett.,2005,15,6,1577,412.46,1.76,120.34,0,Inactive
CHEMBL206290,OC(=O)c1nc(nc(O)c1O)c2cc(NC(=O)c3cccs3)cs2,IC50,=,13800,nM,4.860120914,Q8JXU8,Hepatitis C virus NS5B RNA-dependent RNA polymerase,CHEMBL1138187,Scientific Literature,Inhibitory activity against HCV 1b BK NS5B deltaC55 RNA polymerase,16509585,J. Med. Chem.,2006,49,5,1693,363.37,2.48,189.12,0,Inactive
CHEMBL384794,OC(=O)c1cc2c(nc(c3ccccc3)n2C4CCCCC4)s1,IC50,=,13800,nM,4.860120914,Q8JXU8,Hepatitis C virus NS5B RNA-dependent RNA polymerase,CHEMBL1146030,Scientific Literature,Inhibition of HCV BK NS5B deltaC55 RNA dependent RNA polymerase,16714108,Bioorg. Med. Chem. Lett.,2006,16,15,4026,326.41,4.98,83.36,0,Inactive
CHEMBL264034,COc1ccc(CCNC(=O)c2ccc3c(c2)nc(c4ccc(OCC(=O)NCCCN(C)C)cc4)n3C5CCCCC5)cc1OC,IC50,=,14000,nM,4.853871964,Q8JXU8,Hepatitis C virus NS5B RNA-dependent RNA polymerase,CHEMBL1149223,Scientific Literature,Inhibitory activity against NS5B polymerase of hepatitis C virus,14684311,Bioorg. Med. Chem. Lett.,2004,14,1,119,641.8,5.66,106.95,2,Inactive
CHEMBL424014,Cc1cc(c(C)cc1Cl)S(=O)(=O)Nc2cc(sc2C(=O)N)c3ccccc3,IC50,=,14000,nM,4.853871964,Q8JXU8,Hepatitis C virus NS5B RNA-dependent RNA polymerase,CHEMBL1137977,Scientific Literature,Inhibitory concentration for NS5B RNA-dependent RNA polymerase of Hepatitis C virus,15454222,Bioorg. Med. Chem. Lett.,2004,14,21,5333,420.93,4.72,125.87,0,Inactive
CHEMBL192112,Nc1ccc(Oc2ccc(\C=C(/NC(=O)CCC3CCCC3)\C(=O)O)cc2)c(c1)C(F)(F)F,IC50,=,14000,nM,4.853871964,Q8JXU8,Hepatitis C virus NS5B RNA-dependent RNA polymerase,CHEMBL1145278,Scientific Literature,Inhibitory concentration against RNA dependent RNA polymerase Nonstructural protein 5B (HCV NS5B polymerase) in Hepatitis C virus,15911260,Bioorg. Med. Chem. Lett.,2005,15,11,2812,462.46,4.88,101.65,0,Inactive
CHEMBL197897,Cc1oc(C)c(c1)\C(=C\C(=O)C(=O)O)\O,IC50,=,14000,nM,4.853871964,Q8JXU8,Hepatitis C virus NS5B RNA-dependent RNA polymerase,CHEMBL1140440,Scientific Literature,"Inhibitory concentration against NS5B HCV polymerase using [alpha-32P]UTP as radioligand (30 degree C for 2 h, at pH 7.5 with Tris-HCl buffer)",16190757,J. Med. Chem.,2005,48,20,6304,210.18,0.66,87.74,0,Inactive
CHEMBL383278,OC(=O)C1(CC=C)CCc2c1[nH]c3c(F)ccc(C#N)c23,IC50,=,14500,nM,4.838631998,Q8JXU8,Hepatitis C virus NS5B RNA-dependent RNA polymerase,CHEMBL1147645,Scientific Literature,Inhibition of HCV 1b BK NS5B RNA polymerase,16480869,Bioorg. Med. Chem. Lett.,2006,16,9,2532,284.29,3.68,76.88,0,Inactive
CHEMBL192409,OC(=O)\C(=C\c1ccc(Oc2ccc(F)cc2Br)cc1)\NC(=O)CCC3CCCC3,IC50,=,15000,nM,4.823908741,Q8JXU8,Hepatitis C virus NS5B RNA-dependent RNA polymerase,CHEMBL1145278,Scientific Literature,Inhibitory concentration against RNA dependent RNA polymerase Nonstructural protein 5B (HCV NS5B polymerase) in Hepatitis C virus,15911260,Bioorg. Med. Chem. Lett.,2005,15,11,2812,476.34,5.64,75.63,1,Inactive
CHEMBL195300,Oc1ccccc1NC(=O)\C(=C\c2ccc(Oc3ccccc3Br)cc2)\NC(=O)c4ccccc4,IC50,=,15000,nM,4.823908741,Q8JXU8,Hepatitis C virus NS5B RNA-dependent RNA polymerase,CHEMBL1145278,Scientific Literature,Inhibitory concentration against RNA dependent RNA polymerase Nonstructural protein 5B (HCV NS5B polymerase) in Hepatitis C virus,15911260,Bioorg. Med. Chem. Lett.,2005,15,11,2812,529.38,5.64,87.66,2,Inactive
CHEMBL191813,COc1ccccc1Oc2ccc(\C=C(/NC(=O)c3ccccc3)\C(=O)O)cc2,IC50,=,15000,nM,4.823908741,Q8JXU8,Hepatitis C virus NS5B RNA-dependent RNA polymerase,CHEMBL1140265,Scientific Literature,Inhibitory concentration against Hepatitis C virus NS5B polymerase,15863301,Bioorg. Med. Chem. Lett.,2005,15,10,2481,389.4,3.96,84.86,0,Inactive
CHEMBL208024,CCCC1(CCCc2c1[nH]c3c(C)ccc(C#N)c23)C(=O)O,IC50,=,15000,nM,4.823908741,Q8JXU8,Hepatitis C virus NS5B RNA-dependent RNA polymerase,CHEMBL1147645,Scientific Literature,Inhibition of HCV 1b BK NS5B RNA polymerase,16480869,Bioorg. Med. Chem. Lett.,2006,16,9,2532,296.36,4.81,76.88,0,Inactive
CHEMBL187480,OC(=O)c1sc(cc1NS(=O)(=O)c2ccc(cn2)C(F)(F)F)c3ccccc3,IC50,=,15000,nM,4.823908741,Q8JXU8,Hepatitis C virus NS5B RNA-dependent RNA polymerase,CHEMBL1137977,Scientific Literature,Inhibitory concentration for NS5B RNA-dependent RNA polymerase of Hepatitis C virus,15454222,Bioorg. Med. Chem. Lett.,2004,14,21,5333,428.41,4.04,132.97,0,Inactive
CHEMBL182786,Oc1ncnc2nc(c3ccccc3)c(nc12)c4ccccc4,IC50,=,15000,nM,4.823908741,Q8JXU8,Hepatitis C virus NS5B RNA-dependent RNA polymerase,CHEMBL1144286,Scientific Literature,Inhibitory concentration against RNA dependent RNA polymerase Nonstructural protein 5B of hepatitis C virus,15664835,Bioorg. Med. Chem. Lett.,2005,15,3,675,300.31,3.9,71.79,0,Inactive
CHEMBL197761,O=C1N(NS(=O)(=O)c2ccccc2)C(=S)S/C/1=C\c3ccc4OCOc4c3,IC50,=,15000,nM,4.823908741,Q8JXU8,Hepatitis C virus NS5B RNA-dependent RNA polymerase,CHEMBL1149391,Scientific Literature,Inhibitory activity against HCV delta 21 NS5b RNA polymerase,16451069,J. Med. Chem.,2006,49,3,1034,420.48,3.35,150.7,0,Inactive
CHEMBL197649,O=C1N(NS(=O)(=O)c2ccccc2)C(=S)S/C/1=C\c3cccnc3,IC50,=,15000,nM,4.823908741,Q8JXU8,Hepatitis C virus NS5B RNA-dependent RNA polymerase,CHEMBL1149391,Scientific Literature,Inhibitory activity against HCV delta 21 NS5b RNA polymerase,16451069,J. Med. Chem.,2006,49,3,1034,377.46,2.43,145.13,0,Inactive
CHEMBL181754,OC(=O)c1cnc(s1)N(C2CCCCC2)C(=O)c3ccc(OCc4ccccn4)cc3,IC50,=,15000,nM,4.823908741,Q8JXU8,Hepatitis C virus NS5B RNA-dependent RNA polymerase,CHEMBL1144458,Scientific Literature,Inhibitory concentration against RNA dependent RNA polymerase nonstructural protein 5B of hepatitis C virus,15582422,Bioorg. Med. Chem. Lett.,2005,15,1,115,437.51,4.23,120.86,0,Inactive
CHEMBL280721,OC(=O)[C@H](Cc1ccccc1)N(Cc2cccc(Br)c2)C(=O)c3ccccc3Cl,IC50,=,15000,nM,4.823908741,Q8JXU8,Hepatitis C virus NS5B RNA-dependent RNA polymerase,CHEMBL1144916,Scientific Literature,Inhibitory activity against Hepatitis C RNA dependent RNA polymerase Nonstructural protein 5B (NS5B polymerase) expressed from baculovirus-infected Sf9 insect cells,12672227,J. Med. Chem.,2003,46,8,1283,472.76,5.76,57.61,1,Inactive
CHEMBL84152,COC(=O)N(CC(=O)O)C(=O)c1c(F)ccc2c(c(OC)ccc12)C(F)(F)F,IC50,=,15200,nM,4.818156412,Q8JXU8,Hepatitis C virus NS5B RNA-dependent RNA polymerase,CHEMBL1137155,Scientific Literature,Inhibitory concentration against HCV NS5B RNA dependent RNA polymerase,15261274,Bioorg. Med. Chem. Lett.,2004,14,16,4221,403.28,3.19,93.14,0,Inactive
CHEMBL198366,COc1ccc(Cn2cccc2\C=C\C(=C\C(=O)C(=O)O)\O)cc1,IC50,=,16000,nM,4.795880017,Q8JXU8,Hepatitis C virus NS5B RNA-dependent RNA polymerase,CHEMBL1140440,Scientific Literature,"Inhibitory concentration against NS5B HCV polymerase using [alpha-32P]UTP as radioligand (30 degree C for 2 h, at pH 7.5 with Tris-HCl buffer)",16190757,J. Med. Chem.,2005,48,20,6304,327.33,2.89,88.76,0,Inactive
CHEMBL198879,Cn1cc(cc1\C=C\C(=C\C(=O)C(=O)O)\O)C(=O)c2ccc(F)cc2,IC50,=,16000,nM,4.795880017,Q8JXU8,Hepatitis C virus NS5B RNA-dependent RNA polymerase,CHEMBL1140440,Scientific Literature,"Inhibitory concentration against NS5B HCV polymerase using [alpha-32P]UTP as radioligand (30 degree C for 2 h, at pH 7.5 with Tris-HCl buffer)",16190757,J. Med. Chem.,2005,48,20,6304,343.31,2.93,96.6,0,Inactive
CHEMBL206052,OC(=O)c1nc(nc(O)c1O)c2ccc(s2)[N+](=O)[O-],IC50,=,16000,nM,4.795880017,Q8JXU8,Hepatitis C virus NS5B RNA-dependent RNA polymerase,CHEMBL1138187,Scientific Literature,Inhibitory activity against HCV 1b BK NS5B deltaC55 RNA polymerase,16509585,J. Med. Chem.,2006,49,5,1693,283.22,1.76,177.6,0,Inactive
CHEMBL175533,OC(=O)C(=O)CC(=O)c1cccc(NS(=O)(=O)c2ccccc2)c1,IC50,=,16000,nM,4.795880017,Q8JXU8,Hepatitis C virus NS5B RNA-dependent RNA polymerase,CHEMBL1139456,Scientific Literature,Inhibitory activity against Hepatitis C virus RNA dependent RNA polymerase nonstructural protein 5B,14695815,J. Med. Chem.,2004,47,1,14,347.34,1.74,125.98,0,Inactive
CHEMBL202068,NN1C(=S)S\C(=C/c2ccc(Cl)cc2)\C1=O,IC50,=,16000,nM,4.795880017,Q8JXU8,Hepatitis C virus NS5B RNA-dependent RNA polymerase,CHEMBL1149391,Scientific Literature,Inhibitory activity against HCV delta 21 NS5b RNA polymerase,16451069,J. Med. Chem.,2006,49,3,1034,270.76,3.01,103.72,0,Inactive
CHEMBL183179,CCNc1ncnc2nc(c3ccccc3)c(nc12)c4ccccc4,IC50,=,16000,nM,4.795880017,Q8JXU8,Hepatitis C virus NS5B RNA-dependent RNA polymerase,CHEMBL1144286,Scientific Literature,Inhibitory concentration against RNA dependent RNA polymerase Nonstructural protein 5B of hepatitis C virus,15664835,Bioorg. Med. Chem. Lett.,2005,15,3,675,327.38,4.3,63.59,0,Inactive
CHEMBL200356,CCC1(CC(=O)O)OCCc2c1oc3c(Cl)ccc(Cl)c23,IC50,=,16300,nM,4.787812396,Q8JXU8,Hepatitis C virus NS5B RNA-dependent RNA polymerase,CHEMBL1148590,Scientific Literature,Displacement of [alpha-32P]GTP from recombinant HCV NS5B RNA dependent RNA polymerase,16274990,Bioorg. Med. Chem. Lett.,2006,16,2,457,329.18,4.12,59.67,0,Inactive
CHEMBL367740,OC(=O)C(=O)CC(=O)c1cccc(NCc2ccccc2)c1,IC50,=,16700,nM,4.777283529,Q8JXU8,Hepatitis C virus NS5B RNA-dependent RNA polymerase,CHEMBL1139456,Scientific Literature,Inhibitory activity against Hepatitis C virus RNA dependent RNA polymerase nonstructural protein 5B,14695815,J. Med. Chem.,2004,47,1,14,297.31,2.65,83.47,0,Inactive
CHEMBL371719,OC(=O)C(=O)\C=C(/O)\c1cccc(NCc2ccccc2)c1,IC50,=,17000,nM,4.769551079,Q8JXU8,Hepatitis C virus NS5B RNA-dependent RNA polymerase,CHEMBL1140440,Scientific Literature,"Inhibitory concentration against NS5B HCV polymerase using [alpha-32P]UTP as radioligand (30 degree C for 2 h, at pH 7.5 with Tris-HCl buffer)",16190757,J. Med. Chem.,2005,48,20,6304,297.31,2.66,86.63,0,Inactive
CHEMBL174836,OC(=O)c1ccc2c(c1)nc(c3ccncc3)n2C4CCCCC4,IC50,=,17000,nM,4.769551079,Q8JXU8,Hepatitis C virus NS5B RNA-dependent RNA polymerase,CHEMBL1149223,Scientific Literature,Inhibitory activity against NS5B polymerase of hepatitis C virus,14684311,Bioorg. Med. Chem. Lett.,2004,14,1,119,321.37,3.81,68.01,0,Inactive
CHEMBL195772,OC(=O)\C(=C\c1ccc(Oc2ccccc2)cc1)\NC(=O)c3ccccc3,IC50,=,17000,nM,4.769551079,Q8JXU8,Hepatitis C virus NS5B RNA-dependent RNA polymerase,CHEMBL1140265,Scientific Literature,Inhibitory concentration against Hepatitis C virus NS5B polymerase,15863301,Bioorg. Med. Chem. Lett.,2005,15,10,2481,359.37,3.98,75.63,0,Inactive
CHEMBL378495,OC(=O)c1cc2nc(c3ccccc3)n(C4CCCCC4)c2s1,IC50,=,17200,nM,4.764471553,Q8JXU8,Hepatitis C virus NS5B RNA-dependent RNA polymerase,CHEMBL1146030,Scientific Literature,Inhibition of HCV BK NS5B deltaC55 RNA dependent RNA polymerase,16714108,Bioorg. Med. Chem. Lett.,2006,16,15,4026,326.41,4.8,83.36,0,Inactive
CHEMBL200963,CC1(CC(=O)O)OCCc2c1sc3c(Cl)ccc(Cl)c23,IC50,=,17600,nM,4.754487332,Q8JXU8,Hepatitis C virus NS5B RNA-dependent RNA polymerase,CHEMBL1148590,Scientific Literature,Displacement of [alpha-32P]GTP from recombinant HCV NS5B RNA dependent RNA polymerase,16274990,Bioorg. Med. Chem. Lett.,2006,16,2,457,331.21,4.15,74.77,0,Inactive
CHEMBL197626,O\C(=C/C(=O)C(=O)O)\C=C\c1cccn1Cc2cccc(F)c2,IC50,=,18000,nM,4.744727495,Q8JXU8,Hepatitis C virus NS5B RNA-dependent RNA polymerase,CHEMBL1140440,Scientific Literature,"Inhibitory concentration against NS5B HCV polymerase using [alpha-32P]UTP as radioligand (30 degree C for 2 h, at pH 7.5 with Tris-HCl buffer)",16190757,J. Med. Chem.,2005,48,20,6304,315.3,3.11,79.53,0,Inactive
CHEMBL109516,OC(=O)C1=CC(=O)C(=C(O1)C(=O)O)O,IC50,=,18000,nM,4.744727495,Q8JXU8,Hepatitis C virus NS5B RNA-dependent RNA polymerase,CHEMBL1146656,Scientific Literature,Inhibitory potency of compound in presence of Mn2+ ion against NS5B HCV polymerase,15149686,Bioorg. Med. Chem. Lett.,2004,14,12,3257,200.1,-1.02,121.13,0,Inactive
CHEMBL372525,O\C(=C/C(=O)C(=O)O)\C=C\c1c[nH]c2ccc(Cl)cc12,IC50,=,18000,nM,4.744727495,Q8JXU8,Hepatitis C virus NS5B RNA-dependent RNA polymerase,CHEMBL1140440,Scientific Literature,"Inhibitory concentration against NS5B HCV polymerase using [alpha-32P]UTP as radioligand (30 degree C for 2 h, at pH 7.5 with Tris-HCl buffer)",16190757,J. Med. Chem.,2005,48,20,6304,291.69,2.69,90.39,0,Inactive
CHEMBL360224,CC(C)C[C@]1(C[C@@H]([C@H](N1C(=O)c2ccc(cc2)C(F)(F)F)c3cccs3)C(=O)O)C(=O)O,IC50,=,18000,nM,4.744727495,Q8JXU8,Hepatitis C virus NS5B RNA-dependent RNA polymerase,CHEMBL1142030,Scientific Literature,Inhibitory concentration against Hepatitis C virus RNA dependent RNA polymerase Nonstructural protein 5B,15745795,Bioorg. Med. Chem. Lett.,2005,15,6,1553,469.47,4.59,123.15,0,Inactive
CHEMBL199153,OC(=O)C(=O)\C=C(/O)\c1ccsc1Cc2ccc(F)cc2,IC50,=,18000,nM,4.744727495,Q8JXU8,Hepatitis C virus NS5B RNA-dependent RNA polymerase,CHEMBL1140440,Scientific Literature,"Inhibitory concentration against NS5B HCV polymerase using [alpha-32P]UTP as radioligand (30 degree C for 2 h, at pH 7.5 with Tris-HCl buffer)",16190757,J. Med. Chem.,2005,48,20,6304,306.31,2.98,102.83,0,Inactive
CHEMBL436119,Cc1ccccc1Cn2cccc2\C=C\C(=C\C(=O)C(=O)O)\O,IC50,=,18000,nM,4.744727495,Q8JXU8,Hepatitis C virus NS5B RNA-dependent RNA polymerase,CHEMBL1140440,Scientific Literature,"Inhibitory concentration against NS5B HCV polymerase using [alpha-32P]UTP as radioligand (30 degree C for 2 h, at pH 7.5 with Tris-HCl buffer)",16190757,J. Med. Chem.,2005,48,20,6304,311.33,3.39,79.53,0,Inactive
CHEMBL262732,OC(=O)C(=O)\C=C(/O)\c1cc(I)cn1Cc2ccc(F)cc2,IC50,=,18000,nM,4.744727495,Q8JXU8,Hepatitis C virus NS5B RNA-dependent RNA polymerase,CHEMBL1140440,Scientific Literature,"Inhibitory concentration against NS5B HCV polymerase using [alpha-32P]UTP as radioligand (30 degree C for 2 h, at pH 7.5 with Tris-HCl buffer)",16190757,J. Med. Chem.,2005,48,20,6304,415.16,3.22,79.53,0,Inactive
CHEMBL194519,OC(=O)C(=O)\C=C(/O)\c1cccc(Oc2ccccc2)c1,IC50,=,19000,nM,4.721246399,Q8JXU8,Hepatitis C virus NS5B RNA-dependent RNA polymerase,CHEMBL1140440,Scientific Literature,"Inhibitory concentration against NS5B HCV polymerase using [alpha-32P]UTP as radioligand (30 degree C for 2 h, at pH 7.5 with Tris-HCl buffer)",16190757,J. Med. Chem.,2005,48,20,6304,284.26,2.83,83.83,0,Inactive
CHEMBL173718,CC(=Cc1nc2cc(ccc2n1C3CCCCC3)C(=O)O)C,IC50,=,19000,nM,4.721246399,Q8JXU8,Hepatitis C virus NS5B RNA-dependent RNA polymerase,CHEMBL1149223,Scientific Literature,Inhibitory activity against NS5B polymerase of hepatitis C virus,14684311,Bioorg. Med. Chem. Lett.,2004,14,1,119,298.38,4.85,55.12,0,Inactive
CHEMBL194300,OC(=O)C(=O)Nc1cccc(c1)\C(=C\C(=O)C(=O)O)\O,IC50,=,19000,nM,4.721246399,Q8JXU8,Hepatitis C virus NS5B RNA-dependent RNA polymerase,CHEMBL1140440,Scientific Literature,"Inhibitory concentration against NS5B HCV polymerase using [alpha-32P]UTP as radioligand (30 degree C for 2 h, at pH 7.5 with Tris-HCl buffer)",16190757,J. Med. Chem.,2005,48,20,6304,279.2,0.16,141,0,Inactive
CHEMBL364668,OCc1ccccc1c2ccc(\C=C(/NC(=O)c3ccccc3)\C(=O)O)s2,IC50,=,20000,nM,4.698970004,Q8JXU8,Hepatitis C virus NS5B RNA-dependent RNA polymerase,CHEMBL1140265,Scientific Literature,Inhibitory concentration against Hepatitis C virus NS5B polymerase,15863301,Bioorg. Med. Chem. Lett.,2005,15,10,2481,379.43,3.58,114.87,0,Inactive
CHEMBL195243,COc1ccccc1c2oc(\C=C(/NC(=O)c3ccccc3)\C(=O)O)cc2,IC50,=,20000,nM,4.698970004,Q8JXU8,Hepatitis C virus NS5B RNA-dependent RNA polymerase,CHEMBL1140265,Scientific Literature,Inhibitory concentration against Hepatitis C virus NS5B polymerase,15863301,Bioorg. Med. Chem. Lett.,2005,15,10,2481,363.36,3.61,88.77,0,Inactive
CHEMBL353546,OC(=O)c1ccc2c(c1)nc(C3CCCCC3)n2C4CCCCC4,IC50,=,20000,nM,4.698970004,Q8JXU8,Hepatitis C virus NS5B RNA-dependent RNA polymerase,CHEMBL1149223,Scientific Literature,Inhibitory activity against NS5B polymerase of hepatitis C virus,14684311,Bioorg. Med. Chem. Lett.,2004,14,1,119,326.43,5.43,55.12,1,Inactive
CHEMBL2021379,Nc1nc(O)c2ncn([C@@H]3O[C@H](CO)[C@H](O)[C@H]3O)c2n1,IC50,=,20000,nM,4.698970004,Q8JXU8,Hepatitis C virus NS5B RNA-dependent RNA polymerase,CHEMBL1149159,Scientific Literature,Inhibition HCV NS5B-mediated RNA synthesis,15084127,J. Med. Chem.,2004,47,9,2283,283.24,-1.6,159.76,0,Inactive
CHEMBL360050,CC(C)CON1C(=O)C(=C(O)c2cccnc12)C3=NS(=O)(=O)c4ccccc4N3,IC50,=,20500,nM,4.688246139,Q8JXU8,Hepatitis C virus NS5B RNA-dependent RNA polymerase,CHEMBL1142034,Scientific Literature,Inhibitory concentration against RNA dependent RNA polymerase Nonstructural protein 5B of genotype 1b Hepatitis C virus,15745800,Bioorg. Med. Chem. Lett.,2005,15,6,1577,414.44,1.03,129.57,0,Inactive
CHEMBL361368,CN(C)c1ncnc2nc(c3ccc(F)cc3)c(nc12)c4ccc(F)cc4,IC50,=,21000,nM,4.677780705,Q8JXU8,Hepatitis C virus NS5B RNA-dependent RNA polymerase,CHEMBL1144286,Scientific Literature,Inhibitory concentration against RNA dependent RNA polymerase Nonstructural protein 5B of hepatitis C virus,15664835,Bioorg. Med. Chem. Lett.,2005,15,3,675,363.36,4.72,54.8,0,Inactive
CHEMBL194572,Cn1cc(cc1Cc2cccc(F)c2)\C(=C\C(=O)C(=O)O)\O,IC50,=,21000,nM,4.677780705,Q8JXU8,Hepatitis C virus NS5B RNA-dependent RNA polymerase,CHEMBL1140440,Scientific Literature,"Inhibitory concentration against NS5B HCV polymerase using [alpha-32P]UTP as radioligand (30 degree C for 2 h, at pH 7.5 with Tris-HCl buffer)",16190757,J. Med. Chem.,2005,48,20,6304,303.29,2.62,79.53,0,Inactive
CHEMBL305686,Nc1ncnc2c1ncn2[C@@H]3O[C@H](CO)C[C@H]3O,IC50,=,22000,nM,4.657577319,Q8JXU8,Hepatitis C virus NS5B RNA-dependent RNA polymerase,CHEMBL1149159,Scientific Literature,Inhibition HCV NS5B-mediated RNA synthesis,15084127,J. Med. Chem.,2004,47,9,2283,251.24,-1.31,119.3,0,Inactive
CHEMBL193525,OC(=O)\C(=C\c1oc(cc1)c2ccc(OC(F)(F)F)cc2)\NC(=O)c3ccccc3,IC50,=,22000,nM,4.657577319,Q8JXU8,Hepatitis C virus NS5B RNA-dependent RNA polymerase,CHEMBL1140265,Scientific Literature,Inhibitory concentration against Hepatitis C virus NS5B polymerase,15863301,Bioorg. Med. Chem. Lett.,2005,15,10,2481,417.33,5.74,88.77,1,Inactive
CHEMBL66064,[O-][N+](=O)c1ccc(\C=C\2/SC(=S)NC2=O)cc1,IC50,=,22000,nM,4.657577319,Q8JXU8,Hepatitis C virus NS5B RNA-dependent RNA polymerase,CHEMBL1149391,Scientific Literature,Inhibitory activity against HCV delta 21 NS5b RNA polymerase,16451069,J. Med. Chem.,2006,49,3,1034,266.3,2.74,132.31,0,Inactive
CHEMBL362625,Oc1ncnc2nc(c3ccccc3)c(nc12)c4ccc(cc4)[N+](=O)[O-],IC50,=,23000,nM,4.638272164,Q8JXU8,Hepatitis C virus NS5B RNA-dependent RNA polymerase,CHEMBL1144286,Scientific Literature,Inhibitory concentration against RNA dependent RNA polymerase Nonstructural protein 5B of hepatitis C virus,15664835,Bioorg. Med. Chem. Lett.,2005,15,3,675,345.31,3.8,117.61,0,Inactive
CHEMBL213307,Cc1cccc(CCC2(CC(=O)CC(=O)O2)C3CCCC3)c1,IC50,=,23000,nM,4.638272164,Q8JXU8,Hepatitis C virus NS5B RNA-dependent RNA polymerase,CHEMBL1149470,Scientific Literature,Inhibitory activity against HCV 1b BK NS5B deltaC21 RNA polymerase,16824756,Bioorg. Med. Chem. Lett.,2006,16,18,4834,300.39,4.33,43.37,0,Inactive
CHEMBL372984,OC(=O)C(=O)\C=C(/O)\c1cccn1Cc2ccccc2Cl,IC50,=,24000,nM,4.619788758,Q8JXU8,Hepatitis C virus NS5B RNA-dependent RNA polymerase,CHEMBL1140440,Scientific Literature,"Inhibitory concentration against NS5B HCV polymerase using [alpha-32P]UTP as radioligand (30 degree C for 2 h, at pH 7.5 with Tris-HCl buffer)",16190757,J. Med. Chem.,2005,48,20,6304,305.71,3.1,79.53,0,Inactive
CHEMBL321642,CCNC(=O)C1=CC(=O)C(=C(O1)C(=O)O)O,IC50,=,24000,nM,4.619788758,Q8JXU8,Hepatitis C virus NS5B RNA-dependent RNA polymerase,CHEMBL1146656,Scientific Literature,Inhibitory potency against NS5B HCV polymerase,15149686,Bioorg. Med. Chem. Lett.,2004,14,12,3257,227.17,-1.09,112.93,0,Inactive
CHEMBL426948,CCCCCOc1ccccc1C(=O)CC(=O)C(=O)O,IC50,=,25000,nM,4.602059991,Q8JXU8,Hepatitis C virus NS5B RNA-dependent RNA polymerase,CHEMBL1139456,Scientific Literature,Inhibitory activity against Hepatitis C virus RNA dependent RNA polymerase nonstructural protein 5B,14695815,J. Med. Chem.,2004,47,1,14,278.3,3.03,80.67,0,Inactive
CHEMBL364460,OC(=O)\C(=C\c1oc(cc1)c2cccc(c2)[N+](=O)[O-])\NC(=O)c3ccccc3,IC50,=,25000,nM,4.602059991,Q8JXU8,Hepatitis C virus NS5B RNA-dependent RNA polymerase,CHEMBL1140265,Scientific Literature,Inhibitory concentration against Hepatitis C virus NS5B polymerase,15863301,Bioorg. Med. Chem. Lett.,2005,15,10,2481,378.33,3.52,125.36,0,Inactive
CHEMBL185682,OC(=O)c1sc(cc1NS(=O)(=O)c2ccccn2)c3ccccc3,IC50,=,25000,nM,4.602059991,Q8JXU8,Hepatitis C virus NS5B RNA-dependent RNA polymerase,CHEMBL1137977,Scientific Literature,Inhibitory concentration for NS5B RNA-dependent RNA polymerase of Hepatitis C virus,15454222,Bioorg. Med. Chem. Lett.,2004,14,21,5333,360.41,3.1,132.97,0,Inactive
CHEMBL425754,Cc1cccc(\C=C\2/SC(=S)N(NS(=O)(=O)c3ccccc3)C2=O)c1,IC50,=,25000,nM,4.602059991,Q8JXU8,Hepatitis C virus NS5B RNA-dependent RNA polymerase,CHEMBL1149391,Scientific Literature,Inhibitory activity against HCV delta 21 NS5b RNA polymerase,16451069,J. Med. Chem.,2006,49,3,1034,390.5,4.07,132.25,0,Inactive
CHEMBL180546,Fc1ccc(CCNc2ncnc3nc(c4ccc(F)cc4)c(nc23)c5ccc(F)cc5)cc1,IC50,=,26000,nM,4.585026652,Q8JXU8,Hepatitis C virus NS5B RNA-dependent RNA polymerase,CHEMBL1144286,Scientific Literature,Inhibitory concentration against RNA dependent RNA polymerase Nonstructural protein 5B of hepatitis C virus,15664835,Bioorg. Med. Chem. Lett.,2005,15,3,675,457.45,6.47,63.59,1,Inactive
CHEMBL197118,OC(=O)C(=O)\C=C(/O)\c1cnc2cc(Cl)ccc2c1O,IC50,=,26000,nM,4.585026652,Q8JXU8,Hepatitis C virus NS5B RNA-dependent RNA polymerase,CHEMBL1140440,Scientific Literature,"Inhibitory concentration against NS5B HCV polymerase using [alpha-32P]UTP as radioligand (30 degree C for 2 h, at pH 7.5 with Tris-HCl buffer)",16190757,J. Med. Chem.,2005,48,20,6304,293.66,1.87,107.72,0,Inactive
CHEMBL194131,CSc1ccc(cc1)c2oc(\C=C(/NC(=O)c3ccccc3)\C(=O)O)cc2,IC50,=,27000,nM,4.568636236,Q8JXU8,Hepatitis C virus NS5B RNA-dependent RNA polymerase,CHEMBL1140265,Scientific Literature,Inhibitory concentration against Hepatitis C virus NS5B polymerase,15863301,Bioorg. Med. Chem. Lett.,2005,15,10,2481,379.43,4.16,104.84,0,Inactive
CHEMBL198878,OC(=O)C(=O)\C=C(/O)\c1cc2COc3ccc(F)cc3c2s1,IC50,=,27000,nM,4.568636236,Q8JXU8,Hepatitis C virus NS5B RNA-dependent RNA polymerase,CHEMBL1140440,Scientific Literature,"Inhibitory concentration against NS5B HCV polymerase using [alpha-32P]UTP as radioligand (30 degree C for 2 h, at pH 7.5 with Tris-HCl buffer)",16190757,J. Med. Chem.,2005,48,20,6304,320.29,2.97,112.07,0,Inactive
CHEMBL202133,OC1C(Cc2ccc(Cl)c(Cl)c2)SC(=S)N1NS(=O)(=O)c3ccccc3,IC50,=,27000,nM,4.568636236,Q8JXU8,Hepatitis C virus NS5B RNA-dependent RNA polymerase,CHEMBL1149391,Scientific Literature,Inhibitory activity against HCV delta 21 NS5b RNA polymerase,16451069,J. Med. Chem.,2006,49,3,1034,449.39,5.08,135.41,1,Inactive
CHEMBL175174,NC(=O)c1ccc2c(c1)nc(c3ccccn3)n2C4CCCCC4,IC50,=,27000,nM,4.568636236,Q8JXU8,Hepatitis C virus NS5B RNA-dependent RNA polymerase,CHEMBL1149223,Scientific Literature,Inhibitory activity against NS5B polymerase of hepatitis C virus,14684311,Bioorg. Med. Chem. Lett.,2004,14,1,119,320.39,3.61,73.8,0,Inactive
CHEMBL72928,Nc1ncnc2c1ncn2[C@@H]3O[C@H](CO)[C@@H](F)[C@H]3O,IC50,=,28000,nM,4.552841969,Q8JXU8,Hepatitis C virus NS5B RNA-dependent RNA polymerase,CHEMBL1149159,Scientific Literature,Inhibition HCV NS5B-mediated RNA synthesis,15084127,J. Med. Chem.,2004,47,9,2283,269.23,-0.94,119.31,0,Inactive
CHEMBL197721,OC(=O)C(=O)\C=C(/O)\c1cccc(c1)c2ccccc2,IC50,=,28000,nM,4.552841969,Q8JXU8,Hepatitis C virus NS5B RNA-dependent RNA polymerase,CHEMBL1140440,Scientific Literature,"Inhibitory concentration against NS5B HCV polymerase using [alpha-32P]UTP as radioligand (30 degree C for 2 h, at pH 7.5 with Tris-HCl buffer)",16190757,J. Med. Chem.,2005,48,20,6304,268.26,2.78,74.59,0,Inactive
CHEMBL446444,Cc1ccc(Cn2cccc2\C=C\C(=C\C(=O)C(=O)O)\O)cc1,IC50,=,28000,nM,4.552841969,Q8JXU8,Hepatitis C virus NS5B RNA-dependent RNA polymerase,CHEMBL1140440,Scientific Literature,"Inhibitory concentration against NS5B HCV polymerase using [alpha-32P]UTP as radioligand (30 degree C for 2 h, at pH 7.5 with Tris-HCl buffer)",16190757,J. Med. Chem.,2005,48,20,6304,311.33,3.39,79.53,0,Inactive
CHEMBL174838,OC(=O)c1ccc2c(c1)nc(c3cccnc3)n2C4CCCCC4,IC50,=,28000,nM,4.552841969,Q8JXU8,Hepatitis C virus NS5B RNA-dependent RNA polymerase,CHEMBL1149223,Scientific Literature,Inhibitory activity against NS5B polymerase of hepatitis C virus,14684311,Bioorg. Med. Chem. Lett.,2004,14,1,119,321.37,3.81,68.01,0,Inactive
CHEMBL193480,CC(C)c1ccccc1Oc2ccc(\C=C(/NC(=O)c3ccccc3)\C(=O)O)cc2,IC50,=,28000,nM,4.552841969,Q8JXU8,Hepatitis C virus NS5B RNA-dependent RNA polymerase,CHEMBL1140265,Scientific Literature,Inhibitory concentration against Hepatitis C virus NS5B polymerase,15863301,Bioorg. Med. Chem. Lett.,2005,15,10,2481,401.45,5.17,75.63,1,Inactive
CHEMBL175173,CNC(=O)c1ccc2c(c1)nc(c3ccccn3)n2C4CCCCC4,IC50,=,28000,nM,4.552841969,Q8JXU8,Hepatitis C virus NS5B RNA-dependent RNA polymerase,CHEMBL1149223,Scientific Literature,Inhibitory activity against NS5B polymerase of hepatitis C virus,14684311,Bioorg. Med. Chem. Lett.,2004,14,1,119,334.41,3.82,59.81,0,Inactive
CHEMBL371867,OC(=O)C(=O)\C=C(/O)\c1cccn1Cc2ccccc2,IC50,=,29000,nM,4.537602002,Q8JXU8,Hepatitis C virus NS5B RNA-dependent RNA polymerase,CHEMBL1140440,Scientific Literature,"Inhibitory concentration against NS5B HCV polymerase using [alpha-32P]UTP as radioligand (30 degree C for 2 h, at pH 7.5 with Tris-HCl buffer)",16190757,J. Med. Chem.,2005,48,20,6304,271.27,2.44,79.53,0,Inactive
CHEMBL361600,C1CCCC(CC1)Nc2ncnc3nc(c4ccccc4)c(nc23)c5ccccc5,IC50,=,29000,nM,4.537602002,Q8JXU8,Hepatitis C virus NS5B RNA-dependent RNA polymerase,CHEMBL1144286,Scientific Literature,Inhibitory concentration against RNA dependent RNA polymerase Nonstructural protein 5B of hepatitis C virus,15664835,Bioorg. Med. Chem. Lett.,2005,15,3,675,395.5,6.27,63.59,1,Inactive
CHEMBL206047,CCCC1(CC(=O)O)CCCc2c1[nH]c3cc(F)cc(F)c23,IC50,=,30000,nM,4.522878745,Q8JXU8,Hepatitis C virus NS5B RNA-dependent RNA polymerase,CHEMBL1147645,Scientific Literature,Inhibition of HCV 1b BK NS5B RNA polymerase,16480869,Bioorg. Med. Chem. Lett.,2006,16,9,2532,307.34,4.89,53.09,0,Inactive
CHEMBL202494,CN1C(=S)S\C(=C/c2ccc(cc2)[N+](=O)[O-])\C1=O,IC50,=,30000,nM,4.522878745,Q8JXU8,Hepatitis C virus NS5B RNA-dependent RNA polymerase,CHEMBL1149391,Scientific Literature,Inhibitory activity against HCV delta 21 NS5b RNA polymerase,16451069,J. Med. Chem.,2006,49,3,1034,280.32,2.94,123.51,0,Inactive
CHEMBL175095,OC(=O)C(=O)CC(=O)c1cccc(COc2ccccc2)c1,IC50,=,30000,nM,4.522878745,Q8JXU8,Hepatitis C virus NS5B RNA-dependent RNA polymerase,CHEMBL1139456,Scientific Literature,Inhibitory activity against Hepatitis C virus RNA dependent RNA polymerase nonstructural protein 5B,14695815,J. Med. Chem.,2004,47,1,14,298.29,2.82,80.67,0,Inactive
CHEMBL181908,Oc1ncnc2nc(c3ccc(cc3)[N+](=O)[O-])c(nc12)c4ccccc4,IC50,=,30000,nM,4.522878745,Q8JXU8,Hepatitis C virus NS5B RNA-dependent RNA polymerase,CHEMBL1144286,Scientific Literature,Inhibitory concentration against RNA dependent RNA polymerase Nonstructural protein 5B of hepatitis C virus,15664835,Bioorg. Med. Chem. Lett.,2005,15,3,675,345.31,3.8,117.61,0,Inactive
CHEMBL188277,COC(=O)c1nc(nc(O)c1O)c2ccc(Cl)cc2,IC50,=,30000,nM,4.522878745,Q8JXU8,Hepatitis C virus NS5B RNA-dependent RNA polymerase,CHEMBL1138789,Scientific Literature,Inhibitory concentration required to inhibit HCV RNA dependent RNA polymerase Nonstructural protein 5B in the presence of Mn2+ is determined,15481971,J. Med. Chem.,2004,47,22,5336,280.66,2.67,92.54,0,Inactive
CHEMBL201533,O=C1N(NS(=O)(=O)c2ccccc2)C(=S)S/C/1=C\c3ccccc3,IC50,=,30000,nM,4.522878745,Q8JXU8,Hepatitis C virus NS5B RNA-dependent RNA polymerase,CHEMBL1149391,Scientific Literature,Inhibitory activity against HCV delta 21 NS5b RNA polymerase,16451069,J. Med. Chem.,2006,49,3,1034,376.47,3.58,132.25,0,Inactive
CHEMBL199200,OC(=O)C(=O)\C=C(/O)\c1cccn1Cc2cccc(F)c2,IC50,=,30000,nM,4.522878745,Q8JXU8,Hepatitis C virus NS5B RNA-dependent RNA polymerase,CHEMBL1140440,Scientific Literature,"Inhibitory concentration against NS5B HCV polymerase using [alpha-32P]UTP as radioligand (30 degree C for 2 h, at pH 7.5 with Tris-HCl buffer)",16190757,J. Med. Chem.,2005,48,20,6304,289.26,2.65,79.53,0,Inactive
CHEMBL380801,OC(=O)C(=O)\C=C(/O)\c1cccc(Cc2cc(Br)cc(Br)c2)c1,IC50,=,32000,nM,4.494850022,Q8JXU8,Hepatitis C virus NS5B RNA-dependent RNA polymerase,CHEMBL1140440,Scientific Literature,"Inhibitory concentration against NS5B HCV polymerase using [alpha-32P]UTP as radioligand (30 degree C for 2 h, at pH 7.5 with Tris-HCl buffer)",16190757,J. Med. Chem.,2005,48,20,6304,440.08,4.74,74.59,0,Inactive
CHEMBL324883,CC(C)(C)OC(=O)C1=CC(=O)C(=C(O1)C(=O)O)O,IC50,=,36000,nM,4.443697499,Q8JXU8,Hepatitis C virus NS5B RNA-dependent RNA polymerase,CHEMBL1146656,Scientific Literature,Inhibitory potency against NS5B HCV polymerase,15149686,Bioorg. Med. Chem. Lett.,2004,14,12,3257,256.21,0.14,110.13,0,Inactive
CHEMBL196211,COc1cccc(c1)\C(=C\C(=O)C(=O)O)\O,IC50,=,40000,nM,4.397940009,Q8JXU8,Hepatitis C virus NS5B RNA-dependent RNA polymerase,CHEMBL1140440,Scientific Literature,"Inhibitory concentration against NS5B HCV polymerase using [alpha-32P]UTP as radioligand (30 degree C for 2 h, at pH 7.5 with Tris-HCl buffer)",16190757,J. Med. Chem.,2005,48,20,6304,222.19,1.25,83.83,0,Inactive
CHEMBL199198,OC(=O)C(=O)\C=C(/O)\c1oc(cc1)c2ccc(F)c(Cl)c2,IC50,=,41000,nM,4.387216143,Q8JXU8,Hepatitis C virus NS5B RNA-dependent RNA polymerase,CHEMBL1140440,Scientific Literature,"Inhibitory concentration against NS5B HCV polymerase using [alpha-32P]UTP as radioligand (30 degree C for 2 h, at pH 7.5 with Tris-HCl buffer)",16190757,J. Med. Chem.,2005,48,20,6304,310.66,3.34,87.74,0,Inactive
CHEMBL199199,OC(=O)C(=O)\C=C(/O)\c1ccccc1OCc2ccccc2,IC50,=,44000,nM,4.356547324,Q8JXU8,Hepatitis C virus NS5B RNA-dependent RNA polymerase,CHEMBL1140440,Scientific Literature,"Inhibitory concentration against NS5B HCV polymerase using [alpha-32P]UTP as radioligand (30 degree C for 2 h, at pH 7.5 with Tris-HCl buffer)",16190757,J. Med. Chem.,2005,48,20,6304,298.29,2.83,83.83,0,Inactive
CHEMBL368481,OC(=O)C(=O)CC(=O)c1ccccc1OCc2ccccc2,IC50,=,44000,nM,4.356547324,Q8JXU8,Hepatitis C virus NS5B RNA-dependent RNA polymerase,CHEMBL1139456,Scientific Literature,Inhibitory activity against Hepatitis C virus RNA dependent RNA polymerase nonstructural protein 5B,14695815,J. Med. Chem.,2004,47,1,14,298.29,2.82,80.67,0,Inactive
CHEMBL195087,CC(C)Oc1ccccc1Oc2ccc(\C=C(/NC(=O)c3ccccc3)\C(=O)O)cc2,IC50,=,44000,nM,4.356547324,Q8JXU8,Hepatitis C virus NS5B RNA-dependent RNA polymerase,CHEMBL1140265,Scientific Literature,Inhibitory concentration against Hepatitis C virus NS5B polymerase,15863301,Bioorg. Med. Chem. Lett.,2005,15,10,2481,417.45,4.69,84.86,0,Inactive
CHEMBL174053,OC(=O)c1ccc2c(c1)nc(C(=O)c3ccccc3)n2C4CCCCC4,IC50,=,44000,nM,4.356547324,Q8JXU8,Hepatitis C virus NS5B RNA-dependent RNA polymerase,CHEMBL1149223,Scientific Literature,Inhibitory activity against NS5B polymerase of hepatitis C virus,14684311,Bioorg. Med. Chem. Lett.,2004,14,1,119,348.4,4.85,72.19,0,Inactive
CHEMBL306299,C[C@@]1(O)[C@H](O)[C@@H](CO)O[C@H]1n2cnc3cnc(N)nc23,IC50,=,46000,nM,4.337242168,Q8JXU8,Hepatitis C virus NS5B RNA-dependent RNA polymerase,CHEMBL1149159,Scientific Literature,Inhibition HCV NS5B-mediated RNA synthesis,15084127,J. Med. Chem.,2004,47,9,2283,281.27,-1.69,139.54,0,Inactive
CHEMBL73237,CO[C@@H]1[C@H](O)[C@@H](CO)O[C@H]1n2cnc3c(N)ncnc23,IC50,=,47000,nM,4.327902142,Q8JXU8,Hepatitis C virus NS5B RNA-dependent RNA polymerase,CHEMBL1149159,Scientific Literature,Inhibition HCV NS5B-mediated RNA synthesis,15084127,J. Med. Chem.,2004,47,9,2283,281.27,-1.47,128.54,0,Inactive
CHEMBL174646,CCc1ccc(cc1)C(=O)CC(=O)C(=O)O,IC50,=,47000,nM,4.327902142,Q8JXU8,Hepatitis C virus NS5B RNA-dependent RNA polymerase,CHEMBL1139456,Scientific Literature,Inhibitory activity against Hepatitis C virus RNA dependent RNA polymerase nonstructural protein 5B,14695815,J. Med. Chem.,2004,47,1,14,220.22,2.2,71.44,0,Inactive
CHEMBL195492,OC(=O)\C(=C\c1ccc(Oc2ccccc2C#N)cc1)\NC(=O)c3ccccc3,IC50,=,47000,nM,4.327902142,Q8JXU8,Hepatitis C virus NS5B RNA-dependent RNA polymerase,CHEMBL1140265,Scientific Literature,Inhibitory concentration against Hepatitis C virus NS5B polymerase,15863301,Bioorg. Med. Chem. Lett.,2005,15,10,2481,384.38,3.86,99.42,0,Inactive
CHEMBL198098,Cc1occ(C)c1\C(=C\C(=O)C(=O)O)\O,IC50,=,48000,nM,4.318758763,Q8JXU8,Hepatitis C virus NS5B RNA-dependent RNA polymerase,CHEMBL1140440,Scientific Literature,"Inhibitory concentration against NS5B HCV polymerase using [alpha-32P]UTP as radioligand (30 degree C for 2 h, at pH 7.5 with Tris-HCl buffer)",16190757,J. Med. Chem.,2005,48,20,6304,210.18,1,87.74,0,Inactive
CHEMBL193508,OC(=O)\C(=C\c1ccc(Oc2ccccc2c3ccccc3)cc1)\NC(=O)c4ccccc4,IC50,=,48000,nM,4.318758763,Q8JXU8,Hepatitis C virus NS5B RNA-dependent RNA polymerase,CHEMBL1140265,Scientific Literature,Inhibitory concentration against Hepatitis C virus NS5B polymerase,15863301,Bioorg. Med. Chem. Lett.,2005,15,10,2481,435.47,5.5,75.63,1,Inactive
CHEMBL214680,O=C1CC(=O)OC(CCc2ccccc2)(C1)C3CCCC3,IC50,=,48000,nM,4.318758763,Q8JXU8,Hepatitis C virus NS5B RNA-dependent RNA polymerase,CHEMBL1149470,Scientific Literature,Inhibitory activity against HCV 1b BK NS5B deltaC21 RNA polymerase,16824756,Bioorg. Med. Chem. Lett.,2006,16,18,4834,286.37,3.84,43.37,0,Inactive
CHEMBL407691,Cc1ccc(s1)c2nc(O)c(O)c(n2)C(=O)O,IC50,=,48600,nM,4.313363731,Q8JXU8,Hepatitis C virus NS5B RNA-dependent RNA polymerase,CHEMBL1138187,Scientific Literature,Inhibitory activity against HCV 1b BK NS5B deltaC55 RNA polymerase,16509585,J. Med. Chem.,2006,49,5,1693,252.25,1.88,131.78,0,Inactive
CHEMBL177588,OC(=O)c1ccc2c(c1)nc(c3ccccn3)n2C4CCCCCC4,IC50,=,49000,nM,4.30980392,Q8JXU8,Hepatitis C virus NS5B RNA-dependent RNA polymerase,CHEMBL1149223,Scientific Literature,Inhibitory activity against NS5B polymerase of hepatitis C virus,14684311,Bioorg. Med. Chem. Lett.,2004,14,1,119,335.4,4.7,68.01,0,Inactive
CHEMBL181491,CS(=O)(=O)c1nc(nc(C(=O)O)c1O)c2cccs2,IC50,=,49000,nM,4.30980392,Q8JXU8,Hepatitis C virus NS5B RNA-dependent RNA polymerase,CHEMBL1137893,Scientific Literature,inhibitory concentration against RNA dependent RNA polymerase Nonstructural protein 5B of hepatitis C virus,15380204,Bioorg. Med. Chem. Lett.,2004,14,20,5085,300.31,1.51,154.06,0,Inactive
CHEMBL382966,OC(=O)C(=O)\C=C(/O)\c1cccc(OCc2ccc(cc2)c3ccccc3)c1,IC50,=,50000,nM,4.301029996,Q8JXU8,Hepatitis C virus NS5B RNA-dependent RNA polymerase,CHEMBL1140440,Scientific Literature,"Inhibitory concentration against NS5B HCV polymerase using [alpha-32P]UTP as radioligand (30 degree C for 2 h, at pH 7.5 with Tris-HCl buffer)",16190757,J. Med. Chem.,2005,48,20,6304,374.39,4.35,83.83,0,Inactive
CHEMBL194678,OC(=O)C(=O)\C=C(/O)\c1cccc(OCc2cccc(Oc3ccccc3)c2)c1,IC50,=,50000,nM,4.301029996,Q8JXU8,Hepatitis C virus NS5B RNA-dependent RNA polymerase,CHEMBL1140440,Scientific Literature,"Inhibitory concentration against NS5B HCV polymerase using [alpha-32P]UTP as radioligand (30 degree C for 2 h, at pH 7.5 with Tris-HCl buffer)",16190757,J. Med. Chem.,2005,48,20,6304,390.39,4.39,93.06,0,Inactive
CHEMBL359910,OC1=C(C(=O)N(C2CCCCC2)c3ncccc13)C4=NS(=O)(=O)c5ccccc5N4,IC50,=,50000,nM,4.301029996,Q8JXU8,Hepatitis C virus NS5B RNA-dependent RNA polymerase,CHEMBL1142034,Scientific Literature,Inhibitory concentration against RNA dependent RNA polymerase Nonstructural protein 5B of genotype 1b Hepatitis C virus,15745800,Bioorg. Med. Chem. Lett.,2005,15,6,1577,424.47,1.85,120.34,0,Inactive
CHEMBL1090,Nc1ncnc2c1ncn2[C@@H]3O[C@H](CO)[C@@H](O)[C@@H]3O,IC50,=,50000,nM,4.301029996,Q8JXU8,Hepatitis C virus NS5B RNA-dependent RNA polymerase,CHEMBL1149159,Scientific Literature,Inhibition HCV NS5B-mediated RNA synthesis,15084127,J. Med. Chem.,2004,47,9,2283,267.24,-1.88,139.54,0,Inactive
CHEMBL199039,OC(=O)C(=O)\C=C(/O)\c1occc1,IC50,=,50000,nM,4.301029996,Q8JXU8,Hepatitis C virus NS5B RNA-dependent RNA polymerase,CHEMBL1140440,Scientific Literature,"Inhibitory concentration against NS5B HCV polymerase using [alpha-32P]UTP as radioligand (30 degree C for 2 h, at pH 7.5 with Tris-HCl buffer)",16190757,J. Med. Chem.,2005,48,20,6304,182.13,0.66,87.74,0,Inactive
CHEMBL183018,COc1nc(nc(C(=O)O)c1O)c2cccs2,IC50,=,50000,nM,4.301029996,Q8JXU8,Hepatitis C virus NS5B RNA-dependent RNA polymerase,CHEMBL1137893,Scientific Literature,inhibitory concentration against RNA dependent RNA polymerase Nonstructural protein 5B of hepatitis C virus,15380204,Bioorg. Med. Chem. Lett.,2004,14,20,5085,252.25,1.96,120.78,0,Inactive
CHEMBL177835,CC1CCC(CC1)n2c(nc3cc(ccc23)C(=O)O)c4ccccn4,IC50,=,50000,nM,4.301029996,Q8JXU8,Hepatitis C virus NS5B RNA-dependent RNA polymerase,CHEMBL1149223,Scientific Literature,Inhibitory activity against NS5B polymerase of hepatitis C virus,14684311,Bioorg. Med. Chem. Lett.,2004,14,1,119,335.4,4.49,68.01,0,Inactive
CHEMBL180951,COC(=O)C1CCCN1Nc2ncnc3nc(c4ccc(F)cc4)c(nc23)c5ccc(F)cc5,IC50,=,51000,nM,4.292429824,Q8JXU8,Hepatitis C virus NS5B RNA-dependent RNA polymerase,CHEMBL1144286,Scientific Literature,Inhibitory concentration against RNA dependent RNA polymerase Nonstructural protein 5B of hepatitis C virus,15664835,Bioorg. Med. Chem. Lett.,2005,15,3,675,462.45,4.55,93.13,0,Inactive
CHEMBL109448,OC(=O)C1=C(O)C(=O)C=CO1,IC50,=,51000,nM,4.292429824,Q8JXU8,Hepatitis C virus NS5B RNA-dependent RNA polymerase,CHEMBL1146656,Scientific Literature,Inhibitory potency against NS5B HCV polymerase,15149686,Bioorg. Med. Chem. Lett.,2004,14,12,3257,156.09,-0.88,83.83,0,Inactive
CHEMBL215001,Oc1ccc(CCC2(CC(=O)CC(=O)O2)C3CCCCC3)cc1,IC50,=,52000,nM,4.283996656,Q8JXU8,Hepatitis C virus NS5B RNA-dependent RNA polymerase,CHEMBL1149470,Scientific Literature,Inhibitory activity against HCV 1b BK NS5B deltaC21 RNA polymerase,16824756,Bioorg. Med. Chem. Lett.,2006,16,18,4834,316.39,4.06,63.6,0,Inactive
CHEMBL276969,OC(=O)CN(Cc1cccc(Br)c1)C(=O)c2ccc(Cl)cc2Cl,IC50,=,53000,nM,4.27572413,Q8JXU8,Hepatitis C virus NS5B RNA-dependent RNA polymerase,CHEMBL1144916,Scientific Literature,Inhibitory activity against Hepatitis C RNA dependent RNA polymerase Nonstructural protein 5B (NS5B polymerase) expressed from baculovirus-infected Sf9 insect cells,12672227,J. Med. Chem.,2003,46,8,1283,417.08,4.39,57.61,0,Inactive
CHEMBL180689,Oc1ncnc2nc(c3occc3)c(nc12)c4cocc4,IC50,=,58000,nM,4.236572006,Q8JXU8,Hepatitis C virus NS5B RNA-dependent RNA polymerase,CHEMBL1144286,Scientific Literature,Inhibitory concentration against RNA dependent RNA polymerase Nonstructural protein 5B of hepatitis C virus,15664835,Bioorg. Med. Chem. Lett.,2005,15,3,675,280.24,2.4,98.07,0,Inactive
CHEMBL194900,Cc1oc(cc1)\C(=C\C(=O)C(=O)O)\O,IC50,=,58000,nM,4.236572006,Q8JXU8,Hepatitis C virus NS5B RNA-dependent RNA polymerase,CHEMBL1140440,Scientific Literature,"Inhibitory concentration against NS5B HCV polymerase using [alpha-32P]UTP as radioligand (30 degree C for 2 h, at pH 7.5 with Tris-HCl buffer)",16190757,J. Med. Chem.,2005,48,20,6304,196.16,0.81,87.74,0,Inactive
CHEMBL176038,OC(=O)c1ccc2c(c1)nc(c3oc4ccccc4c3)n2C5CCCCC5,IC50,=,58000,nM,4.236572006,Q8JXU8,Hepatitis C virus NS5B RNA-dependent RNA polymerase,CHEMBL1149223,Scientific Literature,Inhibitory activity against NS5B polymerase of hepatitis C virus,14684311,Bioorg. Med. Chem. Lett.,2004,14,1,119,360.41,5.56,68.26,1,Inactive
CHEMBL360256,OC1=C(C2=NS(=O)(=O)c3ccccc3N2)C(=O)N(OCc4ccccc4)c5ncccc15,IC50,=,58000,nM,4.236572006,Q8JXU8,Hepatitis C virus NS5B RNA-dependent RNA polymerase,CHEMBL1142034,Scientific Literature,Inhibitory concentration against RNA dependent RNA polymerase Nonstructural protein 5B of genotype 1b Hepatitis C virus,15745800,Bioorg. Med. Chem. Lett.,2005,15,6,1577,448.45,1.42,129.57,0,Inactive
CHEMBL177701,CCOC(=O)c1nc2cc(ccc2n1C3CCCCC3)C(=O)O,IC50,=,62000,nM,4.207608311,Q8JXU8,Hepatitis C virus NS5B RNA-dependent RNA polymerase,CHEMBL1149223,Scientific Literature,Inhibitory activity against NS5B polymerase of hepatitis C virus,14684311,Bioorg. Med. Chem. Lett.,2004,14,1,119,316.35,3.65,81.42,0,Inactive
CHEMBL194460,OC(=O)C(=O)\C=C(/O)\c1ccc(Cc2ccc(F)cc2)s1,IC50,=,65000,nM,4.187086643,Q8JXU8,Hepatitis C virus NS5B RNA-dependent RNA polymerase,CHEMBL1140440,Scientific Literature,"Inhibitory concentration against NS5B HCV polymerase using [alpha-32P]UTP as radioligand (30 degree C for 2 h, at pH 7.5 with Tris-HCl buffer)",16190757,J. Med. Chem.,2005,48,20,6304,306.31,3.27,102.84,0,Inactive
CHEMBL363178,OC(=O)\C(=C\c1oc(cc1)c2cccc(OC(F)(F)F)c2)\NC(=O)c3ccccc3,IC50,=,66000,nM,4.180456064,Q8JXU8,Hepatitis C virus NS5B RNA-dependent RNA polymerase,CHEMBL1140265,Scientific Literature,Inhibitory concentration against Hepatitis C virus NS5B polymerase,15863301,Bioorg. Med. Chem. Lett.,2005,15,10,2481,417.33,5.74,88.77,1,Inactive
CHEMBL181773,Fc1ccc(cc1)c2nc3ncnc(N4CCCCC4)c3nc2c5ccc(F)cc5,IC50,=,68000,nM,4.167491087,Q8JXU8,Hepatitis C virus NS5B RNA-dependent RNA polymerase,CHEMBL1144286,Scientific Literature,Inhibitory concentration against RNA dependent RNA polymerase Nonstructural protein 5B of hepatitis C virus,15664835,Bioorg. Med. Chem. Lett.,2005,15,3,675,403.43,5.63,54.8,1,Inactive
CHEMBL196421,OC(=O)C(=O)\C=C(/O)\c1ccc(Cc2ccccc2)s1,IC50,=,68000,nM,4.167491087,Q8JXU8,Hepatitis C virus NS5B RNA-dependent RNA polymerase,CHEMBL1140440,Scientific Literature,"Inhibitory concentration against NS5B HCV polymerase using [alpha-32P]UTP as radioligand (30 degree C for 2 h, at pH 7.5 with Tris-HCl buffer)",16190757,J. Med. Chem.,2005,48,20,6304,288.32,3.06,102.84,0,Inactive
CHEMBL206511,OC(=O)C1=C(O)C(=O)N(CC=C)C(=N1)c2sccc2[N+](=O)[O-],IC50,=,69300,nM,4.159266765,Q8JXU8,Hepatitis C virus NS5B RNA-dependent RNA polymerase,CHEMBL1138187,Scientific Literature,Inhibitory activity against HCV 1b BK NS5B deltaC55 RNA polymerase,16509585,J. Med. Chem.,2006,49,5,1693,323.28,0.91,164.26,0,Inactive
CHEMBL181882,CCCCOCCCNc1ncnc2nc(c3ccc(F)cc3)c(nc12)c4ccc(F)cc4,IC50,=,73000,nM,4.13667714,Q8JXU8,Hepatitis C virus NS5B RNA-dependent RNA polymerase,CHEMBL1144286,Scientific Literature,Inhibitory concentration against RNA dependent RNA polymerase Nonstructural protein 5B of hepatitis C virus,15664835,Bioorg. Med. Chem. Lett.,2005,15,3,675,449.5,5.62,72.82,1,Inactive
CHEMBL372498,OC(=O)\C(=C\c1ccc(Oc2ccccc2[N+](=O)[O-])cc1)\NC(=O)c3ccccc3,IC50,=,73000,nM,4.13667714,Q8JXU8,Hepatitis C virus NS5B RNA-dependent RNA polymerase,CHEMBL1140265,Scientific Literature,Inhibitory concentration against Hepatitis C virus NS5B polymerase,15863301,Bioorg. Med. Chem. Lett.,2005,15,10,2481,404.37,3.87,121.45,0,Inactive
CHEMBL196042,OC(=O)C(=O)\C=C(/O)\c1ccc(Cc2cccc(F)c2)s1,IC50,=,74000,nM,4.13076828,Q8JXU8,Hepatitis C virus NS5B RNA-dependent RNA polymerase,CHEMBL1140440,Scientific Literature,"Inhibitory concentration against NS5B HCV polymerase using [alpha-32P]UTP as radioligand (30 degree C for 2 h, at pH 7.5 with Tris-HCl buffer)",16190757,J. Med. Chem.,2005,48,20,6304,306.31,3.27,102.84,0,Inactive
CHEMBL175685,OC(=O)c1ccc2c(c1)nc(c3ccccn3)n2C4CCC4,IC50,=,76000,nM,4.119186408,Q8JXU8,Hepatitis C virus NS5B RNA-dependent RNA polymerase,CHEMBL1149223,Scientific Literature,Inhibitory activity against NS5B polymerase of hepatitis C virus,14684311,Bioorg. Med. Chem. Lett.,2004,14,1,119,293.32,3.33,68.01,0,Inactive
CHEMBL214165,COc1ccc(cc1)c2nc(\C=C\C(=O)O)cn2C3CCCCC3,IC50,=,77300,nM,4.111820506,Q8JXU8,Hepatitis C virus NS5B RNA-dependent RNA polymerase,CHEMBL1146030,Scientific Literature,Inhibition of HCV BK NS5B deltaC55 RNA dependent RNA polymerase,16714108,Bioorg. Med. Chem. Lett.,2006,16,15,4026,326.39,4.22,64.34,0,Inactive
CHEMBL205086,OC(=O)C1=C(O)C(=O)N(Cc2ccccc2)C(=N1)c3sccc3[N+](=O)[O-],IC50,=,79300,nM,4.100726813,Q8JXU8,Hepatitis C virus NS5B RNA-dependent RNA polymerase,CHEMBL1138187,Scientific Literature,Inhibitory activity against HCV 1b BK NS5B deltaC55 RNA polymerase,16509585,J. Med. Chem.,2006,49,5,1693,373.34,1.88,164.26,0,Inactive
CHEMBL426244,COc1ccccc1CCNc2ncnc3nc(c4ccc(F)cc4)c(nc23)c5ccc(F)cc5,IC50,=,80000,nM,4.096910013,Q8JXU8,Hepatitis C virus NS5B RNA-dependent RNA polymerase,CHEMBL1144286,Scientific Literature,Inhibitory concentration against RNA dependent RNA polymerase Nonstructural protein 5B of hepatitis C virus,15664835,Bioorg. Med. Chem. Lett.,2005,15,3,675,469.49,6.25,72.82,1,Inactive
CHEMBL372675,OC(=O)C(=O)\C=C(/O)\c1ccsc1Cc2cccc(F)c2,IC50,=,80000,nM,4.096910013,Q8JXU8,Hepatitis C virus NS5B RNA-dependent RNA polymerase,CHEMBL1140440,Scientific Literature,"Inhibitory concentration against NS5B HCV polymerase using [alpha-32P]UTP as radioligand (30 degree C for 2 h, at pH 7.5 with Tris-HCl buffer)",16190757,J. Med. Chem.,2005,48,20,6304,306.31,2.98,102.83,0,Inactive
CHEMBL197953,CCCCS(=O)(=O)N1CCCC(Cc2ccc(Cl)cc2)(C1)\C(=C\C(=O)C(=O)O)\O,IC50,=,81400,nM,4.089375595,Q8JXU8,Hepatitis C virus NS5B RNA-dependent RNA polymerase,CHEMBL1140440,Scientific Literature,"Inhibitory concentration against NS5B HCV polymerase using [alpha-32P]UTP as radioligand (30 degree C for 2 h, at pH 7.5 with Tris-HCl buffer)",16190757,J. Med. Chem.,2005,48,20,6304,443.94,3.31,120.36,0,Inactive
CHEMBL198005,OC(=O)C(=O)\C=C(/O)\c1ccc(Cc2cccc(Cl)c2)s1,IC50,=,82000,nM,4.086186148,Q8JXU8,Hepatitis C virus NS5B RNA-dependent RNA polymerase,CHEMBL1140440,Scientific Literature,"Inhibitory concentration against NS5B HCV polymerase using [alpha-32P]UTP as radioligand (30 degree C for 2 h, at pH 7.5 with Tris-HCl buffer)",16190757,J. Med. Chem.,2005,48,20,6304,322.76,3.73,102.84,0,Inactive
CHEMBL364520,OC(=O)C(=O)\C=C(/O)\c1cccc(c1)N2CCCC2,IC50,=,84000,nM,4.075720714,Q8JXU8,Hepatitis C virus NS5B RNA-dependent RNA polymerase,CHEMBL1140440,Scientific Literature,"Inhibitory concentration against NS5B HCV polymerase using [alpha-32P]UTP as radioligand (30 degree C for 2 h, at pH 7.5 with Tris-HCl buffer)",16190757,J. Med. Chem.,2005,48,20,6304,261.27,1.89,77.84,0,Inactive
CHEMBL182741,CCCCOCCCNc1ncnc2nc(c3ccccc3)c(nc12)c4ccccc4,IC50,=,87000,nM,4.060480747,Q8JXU8,Hepatitis C virus NS5B RNA-dependent RNA polymerase,CHEMBL1144286,Scientific Literature,Inhibitory concentration against RNA dependent RNA polymerase Nonstructural protein 5B of hepatitis C virus,15664835,Bioorg. Med. Chem. Lett.,2005,15,3,675,413.51,5.21,72.82,1,Inactive
CHEMBL421353,OC(=O)C(=O)\C=C(/O)\c1cccn1Cc2ccc(F)cc2,IC50,=,93000,nM,4.031517051,Q8JXU8,Hepatitis C virus NS5B RNA-dependent RNA polymerase,CHEMBL1140440,Scientific Literature,"Inhibitory concentration against NS5B HCV polymerase using [alpha-32P]UTP as radioligand (30 degree C for 2 h, at pH 7.5 with Tris-HCl buffer)",16190757,J. Med. Chem.,2005,48,20,6304,289.26,2.65,79.53,0,Inactive
CHEMBL215925,Oc1ccc(CCC2(CC(=O)CC(=O)O2)C3CCC3)cc1,IC50,=,93000,nM,4.031517051,Q8JXU8,Hepatitis C virus NS5B RNA-dependent RNA polymerase,CHEMBL1149470,Scientific Literature,Inhibitory activity against HCV 1b BK NS5B deltaC21 RNA polymerase,16824756,Bioorg. Med. Chem. Lett.,2006,16,18,4834,288.34,3.15,63.6,0,Inactive
CHEMBL178067,Cc1cc(C)c(c(C)c1)c2nc3cc(ccc3n2C4CCCCC4)C(=O)O,IC50,=,120000,nM,3.920818754,Q8JXU8,Hepatitis C virus NS5B RNA-dependent RNA polymerase,CHEMBL1149223,Scientific Literature,Inhibitory activity against NS5B polymerase of hepatitis C virus,14684311,Bioorg. Med. Chem. Lett.,2004,14,1,119,362.46,6.42,55.12,1,Inactive
CHEMBL175762,CCC(CC)n1c(nc2cc(ccc12)C(=O)O)c3ccccn3,IC50,=,139000,nM,3.8569852,Q8JXU8,Hepatitis C virus NS5B RNA-dependent RNA polymerase,CHEMBL1149223,Scientific Literature,Inhibitory activity against NS5B polymerase of hepatitis C virus,14684311,Bioorg. Med. Chem. Lett.,2004,14,1,119,309.36,4.16,68.01,0,Inactive
CHEMBL197882,Cc1sc(cc1\C(=C\C(=O)C(=O)O)\O)c2ccccc2,IC50,=,167000,nM,3.777283529,Q8JXU8,Hepatitis C virus NS5B RNA-dependent RNA polymerase,CHEMBL1140440,Scientific Literature,"Inhibitory concentration against NS5B HCV polymerase using [alpha-32P]UTP as radioligand (30 degree C for 2 h, at pH 7.5 with Tris-HCl buffer)",16190757,J. Med. Chem.,2005,48,20,6304,288.32,2.88,102.83,0,Inactive
CHEMBL177122,OC(=O)c1ccc2c(c1)ncn2C3CCCCC3,IC50,=,186000,nM,3.730487056,Q8JXU8,Hepatitis C virus NS5B RNA-dependent RNA polymerase,CHEMBL1149223,Scientific Literature,Inhibitory activity against NS5B polymerase of hepatitis C virus,14684311,Bioorg. Med. Chem. Lett.,2004,14,1,119,244.29,3.04,55.12,0,Inactive
CHEMBL175454,OC(=O)c1ccc2c(c1)nc(c3ccccn3)n2c4ccccc4,IC50,=,360000,nM,3.443697499,Q8JXU8,Hepatitis C virus NS5B RNA-dependent RNA polymerase,CHEMBL1149223,Scientific Literature,Inhibitory activity against NS5B polymerase of hepatitis C virus,14684311,Bioorg. Med. Chem. Lett.,2004,14,1,119,315.33,3.96,68.01,0,Inactive
CHEMBL369640,CC(C)n1c(nc2cc(ccc12)C(=O)O)c3ccccn3,IC50,=,408000,nM,3.389339837,Q8JXU8,Hepatitis C virus NS5B RNA-dependent RNA polymerase,CHEMBL1149223,Scientific Literature,Inhibitory activity against NS5B polymerase of hepatitis C virus,14684311,Bioorg. Med. Chem. Lett.,2004,14,1,119,281.31,3.11,68.01,0,Inactive