EDDA Study Designs
type: Ontology
revision: 49
date: Aug 17, 2015 10:07:29 AM
comment: Authors: Richard D. Boyce, PhD*, Carol Collins**, John Horn**, Ira Kalet**, John Gennari**. *University of Pittsburgh Department of Biomedical Informatics **All authors are currently with the University of Washington. This project is supported by a grant from the National Library of Medicine: "Addressing gaps in clinically useful evidence on drug-drug interactions" (1R01LM011838-01)
comment: Revisions to the DIKB evidence taxonomy
version info: The Drug Interaction Knowledge Base ontology. This version is reorganizes the evidence taxonomy for retrospective studies to more properly distinguish various observational studies. It also integrates type from EDDA (http://bioportal.bioontology.org/ontologies/EDDA)
comment: This is version 1.0 of the BioPAX Level 3 ontology. The goal of the BioPAX group is to develop a common exchange format for biological pathway data. More information is available at http://www.biopax.org. This ontology is freely available under the LGPL (http://www.gnu.org/copyleft/lesser.html).
comment: This ontology was generated from an ontology revision in WebProtege http://webprotege.stanford.edu
version info: Version 1.6
creator: boycer
creator: system
creator: wenzhang
creator: Tanja Bekhuis
Contributor: Eugene Tseytlin
comment: Micropublications: a Semantic Model for Claims, Evidence, Arguments and Annotations in Biomedical Communications. Author: Tim Clark (1,2,3) Contributors: Paolo Ciccarese (1,2), Carole Goble (3) Version 1.16, September 12, 2013. (1) Massachusetts General Hospital, Dept. of Neurology (2) Harvard Medical School (3) University of Manchester, School of Computer Science
title: EDDA Study Designs and Publications
Format: OWL file
version info: 1.3
version info: 1.16
Source: Comparative Effectiveness Research (CER) Design Terminology, NLM Medical Subject Headings (MeSH), Emtree, National Cancer Institute Thesaurus (NCIT)
description: Terminology of study designs and publication types (beta version). Developed by the Evidence in Documents, Discovery, and Analysis (EDDA) Group. Tanja Bekhuis (PI); Eugene Tseytlin (Systems Developer); Ashleigh Faith (Taxonomist). Department of Biomedical Informatics, University of Pittsburgh School of Medicine, Pennsylvania, US. This work was made possible by the US National Library of Medicine, National Institutes of Health, grant no. R00LM010943. Based on research described in Bekhuis T, Demner-Fushman D, Crowley RS. Comparative effectiveness research designs: an analysis of terms and coverage in Medical Subject Headings (MeSH) and Emtree. Journal of the Medical Library Association (JMLA). 2013 April;101(2):92-100. PMC3634392. The terminology appearing in JMLA has been enriched with terms from MeSH, NCI Thesaurus (NCIT), and Emtree, the controlled vocabularies for MEDLINE, the National Cancer Institute, and Embase, respectively, as well as from published research literature. Variants include synonyms for preferred terms, singular and plural forms, and American and British spellings. Definitions, if they exist, are mainly from MeSH, NCIT, Emtree, and medical dictionaries. A class for Publication Type is included because investigators consider type and design when screening reports for inclusion in comparative effectiveness research.
Contributor: Ashleigh Faith
prior version: 1.15
publisher: National Center for Biomedical Ontology (NCBO) BioPortal

Contributor
comment: An entity responsible for making contributions to the content of the resource.
description: Examples of a Contributor include a person, an organisation, or a service. Typically, the name of a Contributor should be used to indicate the entity.

Creator
comment: An entity primarily responsible for making the content of the resource.
description: Examples of a Creator include a person, an organisation, or a service. Typically, the name of a Creator should be used to indicate the entity.

Date
comment: A date associated with an event in the life cycle of the resource.
description: Typically, Date will be associated with the creation or availability of the resource. Recommended best practice for encoding the date value is defined in a profile of ISO 8601 [W3CDTF] and follows the YYYY-MM-DD format.

Description
type: AnnotationProperty
comment: An account of the content of the resource.
description: Description may include but is not limited to: an abstract, table of contents, reference to a graphical representation of content or a free-text account of the content.

Format
comment: The physical or digital manifestation of the resource.
description: Typically, Format may include the media-type or dimensions of the resource. Format may be used to determine the software, hardware or other equipment needed to display or operate the resource. Examples of dimensions include size and duration. Recommended best practice is to select a value from a controlled vocabulary (for example, the list of Internet Media Types [MIME] defining computer media formats).

Publisher
comment: An entity responsible for making the resource available
description: Examples of a Publisher include a person, an organisation, or a service. Typically, the name of a Publisher should be used to indicate the entity.

Source
comment: A reference to a resource from which the present resource is derived.
description: The present resource may be derived from the Source resource in whole or in part. Recommended best practice is to reference the resource by means of a string or number conforming to a formal identification system.

Title
description: Typically, a Title will be a name by which the resource is formally known.
comment: A name given to the resource.

PhysicalEntity
type: ObjectProperty
type: Class
type: FunctionalProperty
domain: Stoichiometry
subclass of: Entity
disjoint with: ProteinReference
disjoint with: RnaReference
disjoint with: RnaRegionReference
disjoint with: SmallMoleculeReference
disjoint with: TemplateReaction
disjoint with: TemplateReactionRegulation
disjoint with: Transport
disjoint with: TransportWithBiochemicalReaction
comment: Definition: A pool of molecules or molecular complexes. Comments: Each PhysicalEntity is defined by a sequence or structure based EntityReference AND a set of Features. For example, ser46 phosphorylated p53 is a physical entity in BioPAX defined by the p53 sequence and the phosphorylation feature. Features are any combination of cellular location, covalent and non-covalent bonds with other molecules and covalent modifications. For a specific molecule to be a member of the pool it has to satisfy all of the specified features. Unspecified features are treated as don't care. Features that should not be on the molecules should be explicitly stated with "not feature" property. A physical entity in BioPAX never represents a specific molecular instance. Physical Entity can be heterogenous and potentially overlap, i.e. a single molecule can be counted as a member of multiple pools. This makes BioPAX semantics different than regular chemical notation but is necessary for dealing with combinatorial complexity. Synonyms: part, interactor, object, species Examples: extracellular calcium, ser 64 phosphorylated p53
comment: Definition: A pool of molecules or molecular complexes. Comments: Each PhysicalEntity is defined by a sequence or structure based on an EntityReference AND any set of Features that are given. For example, ser46 phosphorylated p53 is a physical entity in BioPAX defined by the p53 sequence and the phosphorylation feature on the serine at position 46 in the sequence. Features are any combination of cellular location, covalent and non-covalent bonds with other molecules and covalent modifications. For a specific molecule to be a member of the pool it has to satisfy all of the specified features. Unspecified features are treated as unknowns or unneccesary. Features that are known to not be on the molecules should be explicitly stated with the "not feature" property. A physical entity in BioPAX never represents a specific molecular instance. Physical Entity can be heterogenous and potentially overlap, i.e. a single molecule can be counted as a member of multiple pools. This makes BioPAX semantics different than regular chemical notation but is necessary for dealing with combinatorial complexity. Synonyms: part, interactor, object, species Examples: extracellular calcium, ser 64 phosphorylated p53
comment: The physical entity to be annotated with stoichiometry.

Xref
type: ObjectProperty
type: Class
domain: Class
  union of: BioSource
  union of: ControlledVocabulary
  union of: Entity
  union of: EntityReference
  union of: Evidence
  union of: Provenance
subclass of: UtilityClass
comment: Definition: A reference from an instance of a class in this ontology to an object in an external resource. Rationale: Xrefs in the future can be removed in the future in favor of explicit miram links. Usage: For most cases one of the subclasses of xref should be used.
comment: Values of this property define external cross-references from this entity to entities in external databases.

absoluteRegion
type: ObjectProperty
type: AsymmetricProperty
type: FunctionalProperty
type: IrreflexiveProperty
comment: Absolute location as defined by the referenced sequence database record. E.g. an operon has a absolute region on the DNA molecule referenced by the UnificationXref.
range: SequenceLocation
domain: Class
  union of: DnaRegionReference
  union of: RnaRegionReference

bindsTo
type: ObjectProperty
type: FunctionalProperty
type: InverseFunctionalProperty
type: SymmetricProperty
comment: A binding feature represents a "half" of the bond between two entities. This property points to another binding feature which represents the other half. The bond can be covalent or non-covalent.
domain: BindingFeature
range: BindingFeature

cellType
type: ObjectProperty
type: AsymmetricProperty
type: FunctionalProperty
type: IrreflexiveProperty
comment: A cell type, e.g. 'HeLa'. This should reference a term in a controlled vocabulary of cell types. Best practice is to refer to OBO Cell Ontology. http://www.obofoundry.org/cgi-bin/detail.cgi?id=cell
domain: BioSource
range: CellVocabulary

cellularLocation
type: ObjectProperty
type: FunctionalProperty
comment: A cellular location, e.g. 'cytoplasm'. This should reference a term in the Gene Ontology Cellular Component ontology. The location referred to by this property should be as specific as is known. If an interaction is known to occur in multiple locations, separate interactions (and physicalEntities) must be created for each different location. If the location of a participant in a complex is unspecified, it may be assumed to be the same location as that of the complex. A molecule in two different cellular locations are considered two different physical entities.
range: CellularLocationVocabulary
domain: PhysicalEntity

cofactor
type: ObjectProperty
type: AsymmetricProperty
type: IrreflexiveProperty
comment: Any cofactor(s) or coenzyme(s) required for catalysis of the conversion by the enzyme. COFACTOR is a sub-property of PARTICIPANTS.
comment: Any cofactor(s) or coenzyme(s) required for catalysis of the conversion by the enzyme. This is a suproperty of participants.
domain: Catalysis
range: PhysicalEntity
sub property of: participant

componentStoichiometry
type: ObjectProperty
comment: The stoichiometry of components in a complex
domain: Complex
range: Stoichiometry

confidence
type: ObjectProperty
type: AsymmetricProperty
type: IrreflexiveProperty
comment: Confidence in the containing instance. Usually a statistical measure.
domain: Evidence
range: Score

controlled
type: ObjectProperty
type: FunctionalProperty
comment: The entity that is controlled, e.g., in a biochemical reaction, the reaction is controlled by an enzyme. CONTROLLED is a sub-property of PARTICIPANTS.
comment: The entity that is controlled, e.g., in a biochemical reaction, the reaction is controlled by an enzyme. Controlled is a sub-property of participants.
domain: Control
sub property of: participant
range: Class
  union of: Interaction
  union of: Pathway

controller
type: ObjectProperty
type: AsymmetricProperty
type: IrreflexiveProperty
comment: The controlling entity, e.g., in a biochemical reaction, an enzyme is the controlling entity of the reaction. CONTROLLER is a sub-property of PARTICIPANTS.
domain: Control
sub property of: participant
range: Class
  union of: Pathway
  union of: PhysicalEntity

dataSource
type: ObjectProperty
comment: A free text description of the source of this data, e.g. a database or person name. This property should be used to describe the source of the data. This is meant to be used by databases that export their data to the BioPAX format or by systems that are integrating data from multiple sources. The granularity of use (specifying the data source in many or few instances) is up to the user. It is intended that this property report the last data source, not all data sources that the data has passed through from creation.
domain: Entity
range: Provenance

deltaG
type: ObjectProperty
comment: For biochemical reactions, this property refers to the standard transformed Gibbs energy change for a reaction written in terms of biochemical reactants (sums of species), delta-G Since Delta-G can change based on multiple factors including ionic strength and temperature a reaction can have multiple DeltaG values.
domain: BiochemicalReaction
range: DeltaG

entityFeature
type: ObjectProperty
type: AsymmetricProperty
type: InverseFunctionalProperty
type: IrreflexiveProperty
comment: Variable features that are observed for the entities of this entityReference - such as known PTM or methylation sites and non-covalent bonds. Note that this is an aggregate list of all known features and it does not represent a state itself.
comment: Variable features that are observed for this entity - such as known PTM or methylation sites and non-covalent bonds.
range: EntityFeature
domain: EntityReference

entityReference
type: ObjectProperty
type: AsymmetricProperty
type: FunctionalProperty
type: IrreflexiveProperty
comment: Reference entity for this physical entity.
range: EntityReference
domain: Class
  union of: Dna
  union of: DnaRegion
  union of: Protein
  union of: Rna
  union of: RnaRegion
  union of: SmallMolecule

entityReferenceType
type: ObjectProperty
type: AsymmetricProperty
type: FunctionalProperty
type: IrreflexiveProperty
comment: A controlled vocabulary term that is used to describe the type of grouping such as homology or functional group.
domain: EntityReference
range: EntityReferenceTypeVocabulary

evidence
type: ObjectProperty
comment: Scientific evidence supporting the existence of the entity as described.
range: Evidence
domain: Class
  union of: Entity
  union of: EntityFeature
  union of: EntityReference
  union of: PathwayStep

evidenceCode
type: ObjectProperty
type: AsymmetricProperty
type: IrreflexiveProperty
comment: A pointer to a term in an external controlled vocabulary, such as the GO, PSI-MI or BioCyc evidence codes, that describes the nature of the support, such as 'traceable author statement' or 'yeast two-hybrid'.
domain: Evidence
range: EvidenceCodeVocabulary

experimentalFeature
type: ObjectProperty
type: AsymmetricProperty
type: IrreflexiveProperty
comment: A feature of the experimental form of the participant of the interaction, such as a protein tag. It is not expected to occur in vivo or be necessary for the interaction.
range: EntityFeature
domain: ExperimentalForm

experimentalForm
type: ObjectProperty
type: AsymmetricProperty
type: IrreflexiveProperty
comment: The experimental forms associated with an evidence instance.
domain: Evidence
range: ExperimentalForm

experimentalFormDescription
type: ObjectProperty
type: AsymmetricProperty
type: IrreflexiveProperty
comment: Descriptor of this experimental form from a controlled vocabulary.
domain: ExperimentalForm
range: ExperimentalFormVocabulary

experimentalFormEntity
type: ObjectProperty
comment: The gene or physical entity that this experimental form describes.
domain: ExperimentalForm
range: Class
  union of: Gene
  union of: PhysicalEntity

feature
type: ObjectProperty
comment: Sequence features of the owner physical entity.
range: EntityFeature
domain: PhysicalEntity

featureLocation
type: ObjectProperty
type: AsymmetricProperty
type: IrreflexiveProperty
comment: Location of the feature on the sequence of the interactor. For modification features this is the modified base or residue. For binding features this is the binding site and for fragment features this is the location of the fragment on the "base" sequence. One feature may have more than one location, used e.g. for features which involve sequence positions close in the folded, three-dimensional state of a protein, but non-continuous along the sequence. Small Molecules can have binding features but currently it is not possible to define the binding site on the small molecules. In those cases this property should not be specified.
comment: Location of the feature on the sequence of the interactor. One feature may have more than one location, used e.g. for features which involve sequence positions close in the folded, three-dimensional state of a protein, but non-continuous along the sequence.
domain: EntityFeature
range: SequenceLocation

featureLocationType
type: ObjectProperty
type: AsymmetricProperty
type: IrreflexiveProperty
comment: A controlled vocabulary term describing the type of the sequence location of the feature such as C-Terminal or SH2 Domain.
comment: A controlled vocabulary term describing the type of the sequence location such as C-Terminal or SH2 Domain.
domain: EntityFeature
range: SequenceRegionVocabulary

interactionScore
type: ObjectProperty
comment: The score of an interaction e.g. a genetic interaction score.
domain: GeneticInteraction
range: Score

interactionType
type: ObjectProperty
comment: Controlled vocabulary annotating the interaction type for example, "phosphorylation reaction". This annotation is meant to be human readable and may not be suitable for computing tasks, like reasoning, that require formal vocabulary systems. For instance, this information would be useful for display on a web page or for querying a database. The PSI-MI interaction type controlled vocabulary should be used. This is browsable at: http://www.ebi.ac.uk/ontology-lookup/browse.do?ontName=MI&termId=MI%3A0190&termName=interaction%20type
comment: External controlled vocabulary annotating the interaction type, for example "phosphorylation". This is annotation useful for e.g. display on a web page or database searching, but may not be suitable for other computing tasks, like reasoning.
domain: Interaction
range: InteractionVocabulary

kEQ
type: ObjectProperty
comment: This quantity is dimensionless and is usually a single number. The measured equilibrium constant for a biochemical reaction, encoded by the slot KEQ, is actually the apparent equilibrium constant, K'. Concentrations in the equilibrium constant equation refer to the total concentrations of all forms of particular biochemical reactants. For example, in the equilibrium constant equation for the biochemical reaction in which ATP is hydrolyzed to ADP and inorganic phosphate: K' = [ADP][Pi]/[ATP], The concentration of ATP refers to the total concentration of all of the following species: [ATP] = [ATP4-] + [HATP3-] + [H2ATP2-] + [MgATP2-] + [MgHATP-] + [Mg2ATP]. The apparent equilibrium constant is formally dimensionless, and can be kept so by inclusion of as many of the terms (1 mol/dm3) in the numerator or denominator as necessary. It is a function of temperature (T), ionic strength (I), pH, and pMg (pMg = -log10[Mg2+]). Therefore, these quantities must be specified to be precise, and values for KEQ for biochemical reactions may be represented as 5-tuples of the form (K' T I pH pMg). This property may have multiple values, representing different measurements for K' obtained under the different experimental conditions listed in the 5-tuple. (This definition adapted from EcoCyc)
domain: BiochemicalReaction
range: KPrime

left
type: ObjectProperty
type: AsymmetricProperty
type: IrreflexiveProperty
comment: The participants on the left side of the conversion interaction. Since conversion interactions may proceed in either the left-to-right or right-to-left direction, occupants of the LEFT property may be either reactants or products. LEFT is a sub-property of PARTICIPANTS.
comment: The participants on the left side of the conversion interaction. Since conversion interactions may proceed in either the left-to-right or right-to-left direction, occupants of the left property may be either reactants or products. left is a sub-property of participants.
domain: Conversion
range: PhysicalEntity
sub property of: participant

memberEntityReference
type: ObjectProperty
comment: An entity reference that qualifies for the definition of this group. For example a member of a PFAM protein family.
range: EntityReference
domain: EntityReference

memberFeature
type: ObjectProperty
type: TransitiveProperty
comment: An entity feature that belongs to this homology grouping. Example: a homologous phosphorylation site across a protein family.
comment: An entity feature that belongs to this homology grouping. These features should be of the same class of this EntityFeature These features should be an EntityFeature of an EntityReference which is a memberEntityReference of the EntityReference of this feature. If this set is not empty than the sequenceLocation of this feature should be non-specified. Example: a homologous phosphorylation site across a protein family.
range: EntityFeature
domain: EntityFeature

memberPhysicalEntity
type: ObjectProperty
type: TransitiveProperty
comment: This property stores the members of a generic physical entity. For representing homology generics a better way is to use generic entity references and generic features. However not all generic logic can be captured by this, such as complex generics or rare cases where feature cardinality is variable. Usages of this property should be limited to such cases.
domain: PhysicalEntity
range: PhysicalEntity

modificationType
type: ObjectProperty
type: AsymmetricProperty
type: FunctionalProperty
type: IrreflexiveProperty
comment: Description and classification of the feature.
domain: ModificationFeature
range: SequenceModificationVocabulary

nextStep
type: ObjectProperty
comment: The next step(s) of the pathway. Contains zero or more pathwayStep instances. If there is no next step, this property is empty. Multiple pathwayStep instances indicate pathway branching.
range: PathwayStep
domain: PathwayStep

notFeature
type: ObjectProperty
comment: Sequence features where the owner physical entity has a feature. If not specified, other potential features are not known.
range: EntityFeature
domain: PhysicalEntity

organism
type: ObjectProperty
type: FunctionalProperty
comment: An organism, e.g. 'Homo sapiens'. This is the organism that the entity is found in. Pathways may not have an organism associated with them, for instance, reference pathways from KEGG. Sequence-based entities (DNA, protein, RNA) may contain an xref to a sequence database that contains organism information, in which case the information should be consistent with the value for ORGANISM.
range: BioSource
domain: Class
  union of: DnaReference
  union of: DnaRegionReference
  union of: Gene
  union of: Pathway
  union of: ProteinReference
  union of: RnaReference
  union of: RnaRegionReference

participant
type: ObjectProperty
comment: This property lists the entities that participate in this interaction. For example, in a biochemical reaction, the participants are the union of the reactants and the products of the reaction. This property has a number of sub-properties, such as LEFT and RIGHT used in the biochemicalInteraction class. Any participant listed in a sub-property will automatically be assumed to also be in PARTICIPANTS by a number of software systems, including Protege, so this property should not contain any instances if there are instances contained in a sub-property.
range: Entity
domain: Interaction

participantStoichiometry
type: ObjectProperty
comment: Stoichiometry of the left and right participants.
domain: Conversion
range: Stoichiometry

pathwayComponent
type: ObjectProperty
comment: The set of interactions and/or pathwaySteps in this pathway/network. Each instance of the pathwayStep class defines: 1) a set of interactions that together define a particular step in the pathway, for example a catalysis instance and the conversion that it catalyzes; 2) an order relationship to one or more other pathway steps (via the NEXT-STEP property). Note: This ordering is not necessarily temporal - the order described may simply represent connectivity between adjacent steps. Temporal ordering information should only be inferred from the direction of each interaction.
domain: Pathway
range: Class
  union of: Interaction
  union of: Pathway

pathwayOrder
type: ObjectProperty
comment: The ordering of components (interactions and pathways) in the context of this pathway. This is useful to specific circular or branched pathways or orderings when component biochemical reactions are normally reversible, but are directed in the context of this pathway.
domain: Pathway
range: PathwayStep

phenotype
type: ObjectProperty
type: FunctionalProperty
comment: The phenotype quality used to define this genetic interaction e.g. viability.
domain: GeneticInteraction
range: PhenotypeVocabulary

physicalEntity
type: ObjectProperty
type: FunctionalProperty
comment: The physical entity to be annotated with stoichiometry.
range: PhysicalEntity
domain: Stoichiometry

product
type: ObjectProperty
type: AsymmetricProperty
type: IrreflexiveProperty
comment: The product of a template reaction.
domain: TemplateReaction
sub property of: participant
range: Class
  union of: Dna
  union of: Protein
  union of: Rna

relationshipType
type: ObjectProperty
type: AsymmetricProperty
type: IrreflexiveProperty
comment: Definition:A controlled vocabulary term that defines the type of relationship that this xref defines. Usage: There is currently no controlled vocabulary of relationship types for BioPAX, although one will be created in the future as the usage of this property increases.
range: RelationshipTypeVocabulary
domain: RelationshipXref

right
type: ObjectProperty
type: AsymmetricProperty
type: IrreflexiveProperty
comment: The participants on the right side of the conversion interaction. Since conversion interactions may proceed in either the left-to-right or right-to-left direction, occupants of the RIGHT property may be either reactants or products. RIGHT is a sub-property of PARTICIPANTS.
domain: Conversion
range: PhysicalEntity
sub property of: participant

scoreSource
type: ObjectProperty
type: AsymmetricProperty
type: FunctionalProperty
type: IrreflexiveProperty
comment: This property defines the source of the scoring methodology -- a publication or web site describing the scoring methodology and the range of values.
range: Provenance
domain: Score

sequenceIntervalBegin
type: ObjectProperty
type: AsymmetricProperty
type: FunctionalProperty
type: IrreflexiveProperty
comment: The begin position of a sequence interval.
domain: SequenceInterval
range: SequenceSite

sequenceIntervalEnd
type: ObjectProperty
type: AsymmetricProperty
type: FunctionalProperty
type: IrreflexiveProperty
comment: The end position of a sequence interval.
domain: SequenceInterval
range: SequenceSite

stepConversion
type: ObjectProperty
type: AsymmetricProperty
type: FunctionalProperty
type: InverseFunctionalProperty
type: IrreflexiveProperty
type: SymmetricProperty
comment: The central process that take place at this step of the biochemical pathway.
sub property of: isCrossFunctionalWith
sub property of: isDifferentiatedFrom
sub property of: arguedBy
sub property of: argues
sub property of: assertedBy
sub property of: asserts
sub property of: attributionAsAuthor
sub property of: attributionAsCurator
sub property of: attributionAsEditor
sub property of: attributionAsPublisher
sub property of: attributionOfAgent
sub property of: authoredBy
sub property of: challengeGraphElementOf
sub property of: curatedBy
sub property of: dataSupports
sub property of: directlyChallengedBy
sub property of: directlyChallenges
sub property of: editedBy
sub property of: formalizedAs
sub property of: formalizes
sub property of: hasAttribution
sub property of: hasChallengeGraphElement
sub property of: hasHolotype
sub property of: hasSupportGraphElement
sub property of: holotypeFor
sub property of: indirectlyChallengedBy
sub property of: indirectlyChallenges
sub property of: methodSupports
sub property of: publishedBy
sub property of: quotedBy
sub property of: quotes
sub property of: referencedBy
sub property of: references
sub property of: semtaggedBy
sub property of: semtags
sub property of: supportGraphElementOf
sub property of: supportedByData
sub property of: supportedByMethod
sub property of: controller of
sub property of: describes
sub property of: effected by alteration of
sub property of: evaluates
sub property of: has been evaluated by
sub property of: has consequence
sub property of: has focus of inquiry
sub property of: has object drug
sub property of: has participants
sub property of: has precipitant drug
sub property of: has sponser
sub property of: has study design
sub property of: has treatment assignment method
sub property of: interaction between is investigated by
sub property of: investigates drug
sub property of: investigates interaction between
sub property of: is a participant in
sub property of: is consequence of
sub property of: is focus of inquiry
sub property of: is investigated by
sub property of: is manufactured by
sub property of: is published in
sub property of: is recorded in
sub property of: is referenced by
sub property of: is stated in
sub property of: is treatment assignment method
sub property of: lowers activation energy of
sub property of: makes the statement
sub property of: manufactures
sub property of: records
sub property of: source of experimental protein
sub property of: sponsers
sub property of: summarizes research on topic
sub property of: tests if drug inhibits
sub property of: tests if drug is substrate of

stepProcess
type: ObjectProperty
comment: An interaction or a pathway that are a part of this pathway step.
domain: PathwayStep
range: Class
  union of: Interaction
  union of: Pathway

structure
type: ObjectProperty
type: AsymmetricProperty
type: FunctionalProperty
type: IrreflexiveProperty
comment: Defines the chemical structure and other information about this molecule, using an instance of class chemicalStructure.
range: ChemicalStructure
domain: SmallMoleculeReference

subRegion
type: ObjectProperty
comment: The sub region of a region or nucleic acid molecule. The sub region must be wholly part of the region, not outside of it.
domain: Class
  union of: DnaReference
  union of: DnaRegionReference
  union of: RnaReference
  union of: RnaRegionReference
range: Class
  union of: DnaRegionReference
  union of: RnaRegionReference

template
type: ObjectProperty
type: AsymmetricProperty
type: FunctionalProperty
type: IrreflexiveProperty
comment: The template molecule that is used in this template reaction.
domain: TemplateReaction
sub property of: participant
range: Class
  union of: Dna
  union of: DnaRegion
  union of: Rna
  union of: RnaRegion

tissue
type: ObjectProperty
type: AsymmetricProperty
type: FunctionalProperty
type: IrreflexiveProperty
comment: An external controlled vocabulary of tissue types.
domain: BioSource
range: TissueVocabulary

xref
type: ObjectProperty
comment: Values of this property define external cross-references from this entity to entities in external databases.
range: Xref
domain: Class
  union of: BioSource
  union of: ControlledVocabulary
  union of: Entity
  union of: EntityReference
  union of: Evidence
  union of: Provenance

author
type: DatatypeProperty
comment: The authors of this publication, one per property value.
domain: PublicationXref
range: string

availability
type: DatatypeProperty
comment: Describes the availability of this data (e.g. a copyright statement).
domain: Entity
range: string

catalysisDirection
type: DatatypeProperty
type: FunctionalProperty
comment: This property represents the direction of this catalysis under all physiological conditions if there is one. Note that chemically a catalyst will increase the rate of the reaction in both directions. In biology, however, there are cases where the enzyme is expressed only when the controlled bidirectional conversion is on one side of the chemical equilibrium [todo : example]. If that is the case and the controller, under biological conditions, is always catalyzing the conversion in one direction then this fact can be captured using this property. If the enzyme is active for both directions, or the conversion is not bidirectional, this property should be left empty.
comment: This property represents the direction of this catalysis under all physiological conditions if there is one. Note that chemically a catalyst will increase the rate of the reaction in both directions. In biology, however, there are cases where the enzyme is expressed only when the controlled bidirectional conversion is on one side of the chemical equilibrium. For example E.Coli's lac operon ensures that lacZ gene is only synthesized when there is enough lactose in the medium. If that is the case and the controller, under biological conditions, is always catalyzing the conversion in one direction then this fact can be captured using this property. If the enzyme is active for both directions, or the conversion is not bidirectional, this property should be left empty.
domain: Catalysis
range: Datatype
  one of: LEFT-TO-RIGHT
  one of: RIGHT-TO-LEFT

chemicalFormula
type: DatatypeProperty
type: FunctionalProperty
comment: The chemical formula of the small molecule. Note: chemical formula can also be stored in the STRUCTURE property (in CML). In case of disagreement between the value of this property and that in the CML file, the CML value takes precedence.
domain: SmallMoleculeReference
range: string

comment
type: DatatypeProperty
comment: Comment on the data in the container class. This property should be used instead of the OWL documentation elements (rdfs:comment) for instances because information in 'comment' is data to be exchanged, whereas the rdfs:comment field is used for metadata about the structure of the BioPAX ontology.
range: string
domain: Class
  union of: Entity
  union of: UtilityClass

controlType
type: DatatypeProperty
type: FunctionalProperty
comment: Defines the nature of the control relationship between the CONTROLLER and the CONTROLLED entities. The following terms are possible values: ACTIVATION: General activation. Compounds that activate the specified enzyme activity by an unknown mechanism. The mechanism is defined as unknown, because either the mechanism has yet to be elucidated in the experimental literature, or the paper(s) curated thus far do not define the mechanism, and a full literature search has yet to be performed. The following term can not be used in the catalysis class: INHIBITION: General inhibition. Compounds that inhibit the specified enzyme activity by an unknown mechanism. The mechanism is defined as unknown, because either the mechanism has yet to be elucidated in the experimental literature, or the paper(s) curated thus far do not define the mechanism, and a full literature search has yet to be performed. The following terms can only be used in the modulation class (these definitions from EcoCyc): INHIBITION-ALLOSTERIC Allosteric inhibitors decrease the specified enzyme activity by binding reversibly to the enzyme and inducing a conformational change that decreases the affinity of the enzyme to its substrates without affecting its VMAX. Allosteric inhibitors can be competitive or noncompetitive inhibitors, therefore, those inhibition categories can be used in conjunction with this category. INHIBITION-COMPETITIVE Competitive inhibitors are compounds that competitively inhibit the specified enzyme activity by binding reversibly to the enzyme and preventing the substrate from binding. Binding of the inhibitor and substrate are mutually exclusive because it is assumed that the inhibitor and substrate can both bind only to the free enzyme. A competitive inhibitor can either bind to the active site of the enzyme, directly excluding the substrate from binding there, or it can bind to another site on the enzyme, altering the conformation of the enzyme such that the substrate can not bind to th…
comment: Defines the nature of the control relationship between the controller and the controlled entities. The following terms are possible values: ACTIVATION: General activation. Compounds that activate the specified enzyme activity by an unknown mechanism. The mechanism is defined as unknown, because either the mechanism has yet to be elucidated in the experimental literature, or the paper(s) curated thus far do not define the mechanism, and a full literature search has yet to be performed. The following term can not be used in the catalysis class: INHIBITION: General inhibition. Compounds that inhibit the specified enzyme activity by an unknown mechanism. The mechanism is defined as unknown, because either the mechanism has yet to be elucidated in the experimental literature, or the paper(s) curated thus far do not define the mechanism, and a full literature search has yet to be performed. The following terms can only be used in the modulation class (these definitions from EcoCyc): INHIBITION-ALLOSTERIC Allosteric inhibitors decrease the specified enzyme activity by binding reversibly to the enzyme and inducing a conformational change that decreases the affinity of the enzyme to its substrates without affecting its VMAX. Allosteric inhibitors can be competitive or noncompetitive inhibitors, therefore, those inhibition categories can be used in conjunction with this category. INHIBITION-COMPETITIVE Competitive inhibitors are compounds that competitively inhibit the specified enzyme activity by binding reversibly to the enzyme and preventing the substrate from binding. Binding of the inhibitor and substrate are mutually exclusive because it is assumed that the inhibitor and substrate can both bind only to the free enzyme. A competitive inhibitor can either bind to the active site of the enzyme, directly excluding the substrate from binding there, or it can bind to another site on the enzyme, altering the conformation of the enzyme such that the substrate can not bind to th…
domain: Control
range: Datatype
  one of: ACTIVATION
  one of: ACTIVATION-ALLOSTERIC
  one of: ACTIVATION-NONALLOSTERIC
  one of: INHIBITION
  one of: INHIBITION-ALLOSTERIC
  one of: INHIBITION-COMPETITIVE
  one of: INHIBITION-IRREVERSIBLE
  one of: INHIBITION-NONCOMPETITIVE
  one of: INHIBITION-OTHER
  one of: INHIBITION-UNCOMPETITIVE

conversionDirection
type: DatatypeProperty
type: FunctionalProperty
comment: This property represents the direction of the reaction. If a reaction is fundamentally irreversible, then it will run in a single direction under all contexts. Otherwise it is reversible.
comment: This property represents the direction of the reaction. If a reaction will run in a single direction under all biological contexts then it is considered irreversible and has a direction. Otherwise it is reversible.
domain: Conversion
range: Datatype
  one of: LEFT-TO-RIGHT
  one of: REVERSIBLE
  one of: RIGHT-TO-LEFT

db
type: DatatypeProperty
type: FunctionalProperty
comment: The name of the external database to which this xref refers.
domain: Xref
range: string

dbVersion
type: DatatypeProperty
type: FunctionalProperty
comment: The version of the external database in which this xref was last known to be valid. Resources may have recommendations for referencing dataset versions. For instance, the Gene Ontology recommends listing the date the GO terms were downloaded.
domain: Xref
range: string

deltaGPrime0
type: DatatypeProperty
type: FunctionalProperty
comment: For biochemical reactions, this property refers to the standard transformed Gibbs energy change for a reaction written in terms of biochemical reactants (sums of species), delta-G'o. delta-G'o = -RT lnK' and delta-G'o = delta-H'o - T delta-S'o delta-G'o has units of kJ/mol. Like K', it is a function of temperature (T), ionic strength (I), pH, and pMg (pMg = -log10[Mg2+]). Therefore, these quantities must be specified, and values for DELTA-G for biochemical reactions are represented as 5-tuples of the form (delta-G'o T I pH pMg).
comment: For biochemical reactions, this property refers to the standard transformed Gibbs energy change for a reaction written in terms of biochemical reactants (sums of species), delta-G'o. delta-G'o = -RT lnK' and delta-G'o = delta-H'o - T delta-S'o delta-G'o has units of kJ/mol. Like K', it is a function of temperature (T), ionic strength (I), pH, and pMg (pMg = -log10[Mg2+]). Therefore, these quantities must be specified, and values for DELTA-G for biochemical reactions are represented as 5-tuples of the form (delta-G'o T I pH pMg). (This definition from EcoCyc)
domain: DeltaG
range: float

deltaH
type: DatatypeProperty
comment: For biochemical reactions, this property refers to the standard transformed enthalpy change for a reaction written in terms of biochemical reactants (sums of species), delta-H'o. delta-G'o = delta-H'o - T delta-S'o Units: kJ/mole (This definition from EcoCyc)
domain: BiochemicalReaction
range: float

deltaS
type: DatatypeProperty
comment: For biochemical reactions, this property refers to the standard transformed entropy change for a reaction written in terms of biochemical reactants (sums of species), delta-S'o. delta-G'o = delta-H'o - T delta-S'o (This definition from EcoCyc)
domain: BiochemicalReaction
range: float

displayName
type: DatatypeProperty
type: FunctionalProperty
comment: An abbreviated name for this entity, preferably a name that is short enough to be used in a visualization application to label a graphical element that represents this entity. If no short name is available, an xref may be used for this purpose by the visualization application.
comment: An abbreviated name for this entity, preferably a name that is short enough to be used in a visualization application to label a graphical element that represents this entity. If no short name is available, an xref may be used for this purpose by the visualization application. Warning: Subproperties of name are functional, that is we expect to have only one standardName and shortName for a given entity. If a user decides to assign a different name to standardName or shortName, they have to remove the old triplet from the model too. If the old name should be retained as a synonym a regular "name" property should also be introduced with the old name.
sub property of: name
range: string

eCNumber
type: DatatypeProperty
comment: The unique number assigned to a reaction by the Enzyme Commission of the International Union of Biochemistry and Molecular Biology. Note that not all biochemical reactions currently have EC numbers assigned to them.
domain: BiochemicalReaction
range: string

id
type: DatatypeProperty
type: FunctionalProperty
comment: The primary identifier in the external database of the object to which this xref refers.
domain: Xref
range: string

idVersion
type: DatatypeProperty
type: FunctionalProperty
comment: The version number of the identifier (ID). E.g. The RefSeq accession number NM_005228.3 should be split into NM_005228 as the ID and 3 as the ID-VERSION.
domain: Xref
range: string

intraMolecular
type: DatatypeProperty
type: FunctionalProperty
comment: This flag represents whether the binding feature is within the same molecule or not.
comment: This flag represents whether the binding feature is within the same molecule or not. A true value implies that the entityReferences of this feature and its binding partner are the same.
domain: BindingFeature
range: boolean

ionicStrength
type: DatatypeProperty
type: FunctionalProperty
comment: The ionic strength is defined as half of the total sum of the concentration (ci) of every ionic species (i) in the solution times the square of its charge (zi). For example, the ionic strength of a 0.1 M solution of CaCl2 is 0.5 x (0.1 x 22 + 0.2 x 12) = 0.3 M
comment: The ionic strength is defined as half of the total sum of the concentration (ci) of every ionic species (i) in the solution times the square of its charge (zi). For example, the ionic strength of a 0.1 M solution of CaCl2 is 0.5 x (0.1 x 22 + 0.2 x 12) = 0.3 M (Definition from http://www.lsbu.ac.uk/biology/enztech/ph.html)
range: float
domain: Class
  union of: DeltaG
  union of: KPrime

kPrime
type: DatatypeProperty
type: FunctionalProperty
comment: The apparent equilibrium constant K'. Concentrations in the equilibrium constant equation refer to the total concentrations of all forms of particular biochemical reactants. For example, in the equilibrium constant equation for the biochemical reaction in which ATP is hydrolyzed to ADP and inorganic phosphate: K' = [ADP][Pi]/[ATP], The concentration of ATP refers to the total concentration of all of the following species: [ATP] = [ATP4-] + [HATP3-] + [H2ATP2-] + [MgATP2-] + [MgHATP-] + [Mg2ATP]. The apparent equilibrium constant is formally dimensionless, and can be kept so by inclusion of as many of the terms (1 mol/dm3) in the numerator or denominator as necessary. It is a function of temperature (T), ionic strength (I), pH, and pMg (pMg = -log10[Mg2+]). (Definition from EcoCyc)
domain: KPrime
range: float

molecularWeight
type: DatatypeProperty
type: FunctionalProperty
comment: Defines the molecular weight of the molecule, in daltons.
domain: SmallMoleculeReference
range: float

name
type: DatatypeProperty
comment: One or more synonyms for the name of this individual. This should include the values of the standardName and displayName property so that it is easy to find all known names in one place.
comment: Synonyms for this entity. standardName and shortName are subproperties of this property and if declared they are automatically considered as names. Warning: Subproperties of name are functional, that is we expect to have only one standardName and shortName for a given entity. If a user decides to assign a different name to standardName or shortName, they have to remove the old triplet from the model too. If the old name should be retained as a synonym a regular "name" property should also be introduced with the old name.
range: string
domain: Class
  union of: BioSource
  union of: Entity
  union of: EntityReference
  union of: Provenance

pMg
type: DatatypeProperty
type: FunctionalProperty
comment: A measure of the concentration of magnesium (Mg) in solution. (pMg = -log10[Mg2+])
range: float
domain: Class
  union of: DeltaG
  union of: KPrime

patoData
type: DatatypeProperty
type: FunctionalProperty
comment: The phenotype data from PATO, formatted as PhenoXML (defined at http://www.fruitfly.org/~cjm/obd/formats.html)
domain: PhenotypeVocabulary
range: string

ph
type: DatatypeProperty
type: FunctionalProperty
comment: A measure of acidity and alkalinity of a solution that is a number on a scale on which a value of 7 represents neutrality and lower numbers indicate increasing acidity and higher numbers increasing alkalinity and on which each unit of change represents a tenfold change in acidity or alkalinity and that is the negative logarithm of the effective hydrogen-ion concentration or hydrogen-ion activity in gram equivalents per liter of the solution. (Definition from Merriam-Webster Dictionary)
range: float
domain: Class
  union of: DeltaG
  union of: KPrime

positionStatus
type: DatatypeProperty
type: FunctionalProperty
comment: The confidence status of the sequence position. This could be: EQUAL: The SEQUENCE-POSITION is known to be at the SEQUENCE-POSITION. GREATER-THAN: The site is greater than the SEQUENCE-POSITION. LESS-THAN: The site is less than the SEQUENCE-POSITION.
domain: SequenceSite
range: Datatype
  one of: EQUAL
  one of: GREATER-THAN
  one of: LESS-THAN

sequence
type: DatatypeProperty
type: FunctionalProperty
comment: Polymer sequence in uppercase letters. For DNA, usually A,C,G,T letters representing the nucleosides of adenine, cytosine, guanine and thymine, respectively; for RNA, usually A, C, U, G; for protein, usually the letters corresponding to the 20 letter IUPAC amino acid code.
range: string
domain: Class
  union of: DnaReference
  union of: DnaRegionReference
  union of: ProteinReference
  union of: RnaReference
  union of: RnaRegionReference

sequencePosition
type: DatatypeProperty
type: FunctionalProperty
comment: The integer listed gives the position. The first base or amino acid is position 1. In combination with the numeric value, the property 'POSITION-STATUS' allows to express fuzzy positions, e.g. 'less than 4'.
domain: SequenceSite
range: int

source
type: DatatypeProperty
comment: The source in which the reference was published, such as: a book title, or a journal title and volume and pages.
domain: PublicationXref
range: string

spontaneous
type: DatatypeProperty
type: FunctionalProperty
comment: Specifies whether a conversion occurs spontaneously or not. If the spontaneity is not known, the SPONTANEOUS property should be left empty.
domain: Conversion
range: boolean

standardName
type: DatatypeProperty
type: FunctionalProperty
comment: The preferred full name for this entity, if exists assigned by a standard nomenclature organization such as HUGO Gene Nomenclature Committee. Warning: Subproperties of name are functional, that is we expect to have only one standardName and shortName for a given entity. If a user decides to assign a different name to standardName or shortName, they have to remove the old triplet from the model too. If the old name should be retained as a synonym a regular "name" property should also be introduced with the old name.
comment: The preferred full name for this entity.
sub property of: name
range: string

stepDirection
type: DatatypeProperty
type: FunctionalProperty
comment: Direction of the conversion in this particular pathway context. This property can be used for annotating direction of enzymatic activity. Even if an enzyme catalyzes a reaction reversibly, the flow of matter through the pathway will force the equilibrium in a given direction for that particular pathway.
domain: BiochemicalPathwayStep
range: Datatype
  one of: LEFT-TO-RIGHT
  one of: REVERSIBLE
  one of: RIGHT-TO-LEFT

stoichiometricCoefficient
type: DatatypeProperty
type: FunctionalProperty
comment: Stoichiometric coefficient for one of the entities in an interaction or complex. This value can be any rational number. Generic values such as "n" or "n+1" should not be used - polymers are currently not covered.
domain: Stoichiometry
range: float

structureData
type: DatatypeProperty
type: FunctionalProperty
comment: This property holds a string of data defining chemical structure or other information, in either the CML or SMILES format, as specified in property Structure-Format. If, for example, the CML format is used, then the value of this property is a string containing the XML encoding of the CML data.
comment: This property holds a string of data defining chemical structure,in one of the three formats:CML, SMILES or InChI. If, for example,the CML format is used, then the value of this property is a string containing the XML encoding of the CML data.
domain: ChemicalStructure
range: string

structureFormat
type: DatatypeProperty
type: FunctionalProperty
comment: This property specifies which format is used to define chemical structure data.
domain: ChemicalStructure
range: Datatype
  one of: CML
  one of: InChI
  one of: SMILES

temperature
type: DatatypeProperty
type: FunctionalProperty
comment: Temperature in Celsius
range: float
domain: Class
  union of: DeltaG
  union of: KPrime

templateDirection
type: DatatypeProperty
type: FunctionalProperty
comment: The direction of the template reaction on the template.
domain: TemplateReaction
range: Datatype
  one of: FORWARD
  one of: REVERSE

term
type: DatatypeProperty
comment: The external controlled vocabulary term.
domain: ControlledVocabulary
range: string

title
type: DatatypeProperty
type: FunctionalProperty
comment: The title of the publication.
domain: PublicationXref
range: string

url
type: DatatypeProperty
comment: The URL at which the publication can be found, if it is available through the Web.
domain: PublicationXref
range: string

value
type: DatatypeProperty
type: FunctionalProperty
comment: The value of the score.
comment: The value of the score. This can be a numerical or categorical value.
domain: Score
range: string

year
type: DatatypeProperty
type: FunctionalProperty
comment: The year in which this publication was published.
domain: PublicationXref
range: int

conference paper
type: Class
subclass of: Publication Type
editor: Tanja Bekhuis
date: January 7, 2015
variant: conference report

Publication Type
variant: PT
definition: Describes the type of material the article represents (e.g., Review, Clinical Trial, Retracted Publication, Letter); see the PubMed Publication Types, e.g., review[pt]. Publication Types are arranged hierarchically with more specific terms arranged beneath broader terms. [http://www.ncbi.nlm.nih.gov/books/NBK3827/#pubmedhelp.Publication_Type_PT, August 2014]
editor: Tanja Bekhuis

single blind design
type: Class
subclass of: Study Design
variant: single blind trials
variant: single blind studies
variant: single blind method
variant: single blind methods
variant: single blind study
variant: single blind designs
variant: single blind trial

Study Design
UMLS CUI: C0035171
variant: Study Type
definition: A plan detailing how a study will be performed in order to represent the phenomenon under examination, to answer the research questions that have been asked, and defining the methods of data analysis. Study design is driven by research hypothesis being posed, study subject/population/sample available, logistics/resources: technology, support, networking, collaborative support, etc. Describes the role the study plays in determining the interventions a subject receives. [NCIT_14.05d] [Contributing_Source_CDISC]
editor: Tanja Bekhuis
variant: Research Design
semantic type: Research Activity
variant: STYPE
NCI thesaurus code: C15320

abstract
type: Class
subclass of: Publication Type
editor: Tanja Bekhuis
variant: summary
variant: abstract reports
semantic type: Intellectual Product
variant: abstract report
legacy term: Abstract Document
variant: synopses
NCI thesaurus code: C60765
UMLS CUI: C0600678
variant: synopsis
variant: summaries
definition: A written summary of the important points of a scientific article. [NCIT_14.08d]
variant: abstracts

adaptive design
type: Class
subclass of: Study Design
variant: adaptive designs
variant: adaptive studies
variant: adaptive study
variant: adaptive trial
variant: adaptive trials
semantic type: Research Activity
NCI thesaurus code: C98704
variant: ADAPT
definition: A study design which includes a prospectively planned opportunity for modification of one or more specified aspects of the study design and/or hypotheses based on analysis of data, usually interim data. [NCIT_14.05d] [Contributing_Source_CDISC]
editor: Ashleigh Faith
UMLS CUI: C3274373

address
type: Class
subclass of: Publication Type
variant: addresses
semantic type: Manufactured Object
UMLS CUI: C0376649
definition: A formal speech or report. [NCIT_14.08d]
NCI thesaurus code: C86945
editor: Tanja Bekhuis

analytical design
type: Class
subclass of: Study Design
editor: Ashleigh Faith
variant: analytic design
variant: analytic designs
variant: analytic research
variant: analytic studies
variant: analytic study
variant: analytic trial
variant: analytic trials
variant: analytical designs
variant: analytical research
variant: analytical studies
variant: analytical study
variant: analytical trial
variant: analytical trials

animal study
type: Class
subclass of: Study Design
variant: animal experiments
NCI thesaurus code: C93130
variant: animal studies
UMLS CUI: C0683949
definition: A laboratory experiment using animals to study the development and progression of diseases. Animal studies also test how safe and effective new treatments are before they are tested in people. [NCIT_14.08d]
semantic type: Research Activity
editor: Tanja Bekhuis
variant: animal experiment

article
type: Class
subclass of: Publication Type
editor: Tanja Bekhuis
UMLS CUI: C1706852
date: November 13, 2014
definition: Nonfictional prose forming an independent part of a publication. [NCIT_14.10d] [Contributing_Source_FDA]
NCI thesaurus code: C47902
variant: articles
semantic type: Intellectual Product

before-after design
type: Class
subclass of: Study Design
variant: before-after designs
variant: before-after studies
variant: before-after study
variant: before-after trial
variant: before-after trials
variant: before-and-after design
variant: before-and-after designs
variant: before-and-after studies
variant: before-and-after study
variant: before-and-after trial
variant: before-and-after trials

bibliography
type: Class
subclass of: Publication Type
variant: resource guide
semantic type: Intellectual Product
variant: Resource Guides
editor: Ashleigh Faith
definition: A work consisting of a list of books, articles, documents, publications, and other items, usually on a single subject or related subjects. [MeSH_2014]
semantic type: Manufactured Object
me SH code: D016417
variant: bibliographies

biobibliography
type: Class
subclass of: bibliography
editor: Tanja Bekhuis
definition: A bibliography containing biographical information about the author(s). [Oxford Dictionaries. Oxford University Press. http://www.oxforddictionaries.com/us/definition/american_english/biobibliography]
date: April 15, 2015
variant: biobibliographies

biography
type: Class
subclass of: Publication Type
variant: obituaries
editor: Ashleigh Faith
variant: obituary
semantic type: Intellectual Product
variant: Autobiography
variant: autobiographies
definition: Works consisting of an account of the events, works, and achievements, personal and professional, during a person's life. It includes articles on the activities and accomplishments of living persons as well as the presentation of an obituary.[MeSH_2014]
me SH code: D019215
variant: biographies

biosurveillance
type: Class
subclass of: population surveillance
legacy term: population surveillance
me SH code: D055877
editor: Tanja Bekhuis
semantic type: Health Care Activity
definition: Monitoring of information sources of potential value in detecting an emerging epidemic, whether naturally occurring or the result of bioterrorism. [MeSH_2014]

case control design
type: Class
subclass of: controlled design
me SH code: D016022
semantic type: Research Activity
variant: case control designs
variant: case control studies
variant: case control study
variant: case control trial
variant: case control trials
variant: case-comparison studies
variant: case-compeer studies
variant: case-control design
variant: case-control designs
variant: case-control studies
variant: case-control study
variant: case-control trial
variant: case-control trials
variant: case-referent studies
variant: case-referrent study
variant: control study, case
UMLS CUI: C0007328
variant: case-base design
variant: case base study
variant: case base studies
variant: case base designs
NCI thesaurus code: C15197
variant: case base design
variant: case-base study
editor: Ashleigh Faith
definition: Studies which start with the identification of persons with a disease of interest and a control (comparison, referent) group without the disease. The relationship of an attribute to the disease is examined by comparing diseased and non-diseased persons with regard to the frequency or levels of the attribute in each group. [MeSH_2014]
variant: case-base designs
variant: case-base studies
definition: A study that compares two groups of people: those with the disease or condition under study (cases) and a very similar group of people who do not have the disease or condition (controls). Researchers study the medical and lifestyle histories of the people in each group to learn what factors may be associated with the disease or condition. For example, one group may have been exposed to a particular substance that the other was not. [NCIT_14.05d]

case study
type: Class
subclass of: Study Design
variant: case designs
variant: case studies
variant: case study
variant: case trial
variant: case trials
variant: case reports
editor: Ashleigh Faith
semantic type: Intellectual Product
definition: Used for original items reporting clinical work on not more than 4 individual cases. [Emtree_2014]
variant: case report
variant: case design
NCI thesaurus code: C15362
UMLS CUI: C0085973
definition: An uncontrolled observational study containing a detailed report of the diagnosis, treatment, and follow-up of an individual patient. Case reports also contain some demographic information about the patient (for example, age, gender, ethnic origin). [NCIT_14.05d]
definition: A detailed report of the diagnosis, treatment, and follow-up of an individual patient. Case reports also contain some demographic information about the patient (for example, age, gender, ethnic origin). [Case study | NCIT_14.05d]
definition: A study that identifies and samples individuals with a particular disease or condition, noting characteristics of the disease or condition and persons afflicted. Case studies are often used to call attention to new diseases or to diseases entering new populations. [Emtree_2014] [Dorland's Medical Dictionary_2011]
definition: Clinical presentations that may be followed by evaluative studies that eventually lead to a diagnosis. [Case report | MeSH_2014]
me SH code: D002363
variant: case histories
variant: case history
semantic type: Research Activity

case series
type: Class
subclass of: Study Design
editor: Ashleigh Faith
variant: case series design
variant: case series designs
variant: case series studies
variant: case series study
variant: case series trial
variant: case series trials
variant: large case series
UMLS CUI: C0150093
semantic type: Research Activity
definition: A group or series of case reports involving patients who were given similar treatment. Reports of case series usually contain detailed information about the individual patients. This includes demographic information (for example, age, gender, ethnic origin) and information on diagnosis, treatment, response to treatment, and follow-up after treatment. [NCIT_14.05d]
NCI thesaurus code: C16229
definition: a study that identifies and samples individuals with a particular disease or condition, noting characteristics of the disease or condition and persons afflicted. Case studies are often used to call attention to new diseases or to diseases entering new populations. [Case study | Emtree_2014] [Dorland's Medical Dictionary_2011]

clinical audit
type: Class
subclass of: records review
variant: Clinical governance
editor: Ashleigh Faith
semantic type: Health Care Activity
definition: A detailed review and evaluation of selected clinical records by qualified professional personnel to improve the quality of patient care and outcomes. The clinical audit was formally introduced in 1993 into the United Kingdom's National Health Service. [MeSH_2014]
me SH code: D054869

clinical trial
type: Class
subclass of: Study Design
variant: trial, clinical
legacy term: Clinical Trial Generic
variant: clinical trial
variant: Clinical Trial
NCI thesaurus code: C71104
definition: A type of research study that tests how well new medical approaches work in people. These studies test new methods of screening, prevention, diagnosis, or treatment of a disease. [NCIT_14.05d]
semantic type: Research Activity
variant: Clinical Trials
definition: A research study that prospectively assigns human participants or groups of humans to one or more health-related interventions to evaluate the effects on health outcomes. [NCIT_14.05d]
UMLS CUI: C0008976
editor: Ashleigh Faith
variant: Clinical Trials, Unspecified

closed cohort study
type: Class
subclass of: cohort study
variant: closed cohort studies
variant: cohort studies, closed
variant: cohort study, closed
variant: studies, closed cohort
variant: study, closed cohort

cluster quasi randomized controlled design
type: Class
subclass of: quasi randomized controlled design
variant: Cluster non-randomized controlled design
variant: cluster quasi randomised controlled design
variant: cluster quasi randomised controlled designs
variant: cluster quasi randomised controlled studies
variant: cluster quasi randomised controlled study
variant: cluster quasi randomised controlled trial
variant: cluster quasi randomised controlled trials
variant: cluster quasi randomized controlled designs
variant: cluster quasi randomized controlled studies
variant: cluster quasi randomized controlled study
variant: cluster quasi randomized controlled trial
variant: cluster quasi randomized controlled trials
variant: cluster quasi-randomised controlled design
variant: cluster quasi-randomised controlled designs
variant: cluster quasi-randomised controlled studies
variant: cluster quasi-randomised controlled study
variant: cluster quasi-randomised controlled trial
variant: cluster quasi-randomised controlled trials
variant: cluster quasi-randomized controlled design
variant: cluster quasi-randomized controlled designs
variant: cluster quasi-randomized controlled studies
variant: cluster quasi-randomized controlled study
variant: cluster quasi-randomized controlled trial
variant: cluster quasi-randomized controlled trials
editor: Ashleigh Faith

cluster randomized controlled design
type: Class
subclass of: cluster randomized design
variant: cluster randomised controlled design
variant: cluster randomised controlled designs
variant: cluster randomised controlled studies
variant: cluster randomised controlled study
variant: cluster randomised controlled trial
variant: cluster randomised controlled trials
variant: cluster randomized controlled designs
variant: cluster randomized controlled studies
variant: cluster randomized controlled study
variant: cluster randomized controlled trial
variant: cluster randomized controlled trials

cluster randomized design
type: Class
subclass of: randomized design
variant: cluster randomised design
variant: cluster randomised designs
variant: cluster randomised studies
variant: cluster randomised study
variant: cluster randomised trial
variant: cluster randomised trials
variant: cluster randomized designs
variant: cluster randomized studies
variant: cluster randomized study
variant: cluster randomized trial
variant: cluster randomized trials

cohort before-after design
type: Class
subclass of: before-after design
subclass of: cohort study
variant: cohort before-after designs
variant: cohort before-after studies
variant: cohort before-after study
variant: cohort before-after trial
variant: cohort before-after trials
variant: cohort before-and-after design
variant: cohort before-and-after designs
variant: cohort before-and-after studies
variant: cohort before-and-after study
variant: cohort before-and-after trial
variant: cohort before-and-after trials

cohort study
type: Class
subclass of: Study Design
editor: Ashleigh Faith
me SH code: D015331
definition: Studies in which subsets of a defined population are identified. These groups may or may not be exposed to factors hypothesized to influence the probability of the occurrence of a particular disease or other outcome. Cohorts are defined populations which, as a whole, are followed in an attempt to determine distinguishing subgroup characteristics. [Cohort studies | MeSH_2014]
variant: cohort design
variant: cohort designs
variant: cohort studies
variant: cohort trial
variant: cohort trials
NCI thesaurus code: C15208
definition: A research study that compares a particular outcome (such as lung cancer) in groups of individuals who are alike in many ways but differ by a certain characteristic (for example, female nurses who smoke compared with those who do not smoke). [NCIT_14.05d]
UMLS CUI: C0009247
variant: analysis, cohort
variant: cohort analysis
semantic type: Research Activity

comment
type: Class
subclass of: Publication Type
variant: comments
UMLS CUI: C0947611
variant: Viewpoint
variant: note
variant: notes
semantic type: Intellectual Product
variant: editorial comments
variant: Remark
variant: commentary
definition: A written explanation, observation or criticism added to textual material. [NCIT_14.05d] [Contributing_Source_BRIDG]
me SH code: D016420
variant: viewpoints
variant: Editorial Comment
editor: Ashleigh Faith; Tanja Bekhuis
variant: Remarks
definition: Work consisting of a critical or explanatory note written to discuss, support, or dispute an article or other presentation previously published. It may take the form of an article, letter, editorial, etc. It appears in publications under a variety of names: comment, commentary, editorial comment, viewpoint, etc. [MeSH_2014]
variant: commentaries
NCI thesaurus code: C25393
date: April 14, 2015
definition: note = note, discussion or commentary [Emtree Scope Note, April 14, 2015]

community trial
type: Class
subclass of: Study Design
variant: community design
variant: community designs
variant: community studies
variant: community study
variant: community trials
definition: The Community Trial is a planned experiment that involves administering an exposure within a community in order to elucidate its impact on the incidence of a specific disease in that community. The community trial is a choice when exposure cannot be prevented among control group. [NCIT_14.05d]
NCI thesaurus code: C39365
semantic type: Research Activity
editor: Ashleigh Faith
UMLS CUI: C1516736

comparative study
type: Class
subclass of: Study Design
variant: comparative design
variant: comparative designs
variant: comparative studies
variant: comparative trial
variant: comparative trials
definition: Comparison of outcomes, results, responses, etc for different techniques, therapeutic approaches or other inputs. [Comparitive study | MeSH_2014]
semantic type: Research Activity
editor: Ashleigh Faith
me SH code: D003160
semantic type: Intellectual Product

concurrent design
type: Class
subclass of: cohort study
variant: concurrent designs
variant: concurrent studies
variant: concurrent study
variant: concurrent trial
variant: concurrent trials
variant: studies, concurrent

conference proceedings
type: Class
subclass of: Publication Type
editor: Tanja Bekhuis
semantic type: Intellectual Product
variant: Conferences and Proceedings
me SH code: D003226
semantic type: Manufactured Object

consecutive case series
type: Class
subclass of: case series
UMLS CUI: C2985408
NCI thesaurus code: C93041
definition: A clinical study that includes all eligible patients identified by the researchers during the study registration period. The patients are treated in the order in which they are identified. This type of study usually does not have a control group. [NCIT_14.08d]
semantic type: Research Activity
editor: Tanja Bekhuis

controlled before-after design
type: Class
subclass of: before-after design
variant: controlled before-after designs
variant: controlled before-after studies
variant: controlled before-after study
variant: controlled before-after trial
variant: controlled before-after trials
variant: controlled before-and-after design
variant: controlled before-and-after designs
variant: controlled before-and-after studies
variant: controlled before-and-after study
variant: controlled before-and-after trial
variant: controlled before-and-after trials
me SH code: D065187
semantic type: Quantitative Concept
editor: Tanja Bekhuis
date: November 7, 2014
definition: A study in which observations are made before and after an intervention, both in a group that receives the intervention and in a control group that does not. [Controlled Before-After Studies | MeSH_2015]
semantic type: Research Activity

controlled clinical trial
type: Class
subclass of: clinical trial
subclass of: controlled design
definition: Work consisting of a clinical trial involving one or more test treatments, at least one control treatment, specified outcome measures for evaluating the studied intervention, and a bias-free method for assigning patients to the test treatment. The treatment may be drugs, devices, or procedures studied for diagnostic, therapeutic, or prophylactic effectiveness. Control measures include placebos, active medicine, no-treatment, dosage forms and regimens, historical comparisons, etc. [MeSH_2014]
variant: clinical trial, controlled
variant: controlled clinical design
variant: controlled clinical designs
variant: controlled clinical studies
variant: controlled clinical study
variant: controlled clinical trials
editor: Ashleigh Faith
semantic type: Research Activity
semantic type: Therapeutic or Preventive Procedure
me SH code: D018848
semantic type: Intellectual Product

controlled cohort before-after design
type: Class
subclass of: cohort before-after design
variant: controlled cohort before-after designs
variant: controlled cohort before-after studies
variant: controlled cohort before-after study
variant: controlled cohort before-after trial
variant: controlled cohort before-after trials
variant: controlled cohort before-and-after design
variant: controlled cohort before-and-after designs
variant: controlled cohort before-and-after studies
variant: controlled cohort before-and-after study
variant: controlled cohort before-and-after trial
variant: controlled cohort before-and-after trials

controlled design
type: Class
subclass of: Study Design
variant: controlled designs
variant: controlled studies
variant: controlled study
variant: controlled trial
variant: controlled trials
NCI thesaurus code: C28279
UMLS CUI: C0681867
editor: Ashleigh Faith
definition: An experiment or clinical trial that includes a comparison (control) group. [NCIT_14.05d]
semantic type: Research Activity
definition: Used for original studies with a control group, i.e. in which previously defined groups are compared with each other. Also used for studies with control material or control procedures. Retrospective studies may also be included. [Emtree_2014]

controlled interrupted time series
type: Class
subclass of: interrupted time series design

correlational design
type: Class
subclass of: Study Design
variant: correlation design
variant: correlation designs
variant: correlation studies
variant: correlation study
variant: correlation trial
variant: correlation trials
variant: correlational designs
variant: correlational studies
variant: correlational study
variant: correlational trial
variant: correlational trials

cross-over design
type: Class
subclass of: Study Design
me SH code: D018592
semantic type: Research Activity
definition: Studies comparing two or more treatments or interventions in which the subjects or patients, upon completion of the course of one treatment, are switched to another. In the case of two treatments, A and B, half the subjects are randomly allocated to receive these in the order A, B and half to receive them in the order B, A. A criticism of this design is that effects of the first treatment may carry over into the period when the second is given. [MeSH_2014]
variant: cross over study
variant: cross-over designs
variant: cross-over studies
variant: cross-over study
variant: cross-over study designs
variant: cross-over trial
variant: cross-over trials
variant: crossover design
variant: crossover designs
variant: crossover procedure
variant: crossover studies
variant: crossover study
variant: crossover study design
variant: crossover trial
variant: crossover trials
variant: procedure, crossover
definition: A type of clinical study in which each study subject receives the same series of treatments but in a random order that differs across arms of the study. Each subject serves as their own control in this type of study. [NCIT_14.05d]
NCI thesaurus code: C82637
editor: Tanja Bekhuis
UMLS CUI: C0150097
definition: Participants receive one of two or more alternative intervention(s) during the initial epoch of the study and receive other intervention(s) during the subsequent epoch(s) of the study. [NCIT_14.05d] [Contributing_Source_CDISC]
definition: A crossover design, sometimes called a counterbalanced design, is a type of experimental design in which every subject is exposed to every treatment in a balanced fashion. If there are just two treatments, at Time 1 half of the subjects receive Treatment A and the other half receive Treatment B. At Time 2 they ‘cross over,’ with the first half receiving Treatment B and the second half receiving Treatment A. Crossover designs are ‘Latin square’ designs in which each of k treatments is administered to each of k groups of subjects at k points in time (where k is equal to or greater than 2). They can also be used in assessing reliability when parallel forms are used. [Dictionary of nursing theory and research_2010]
variant: Crossover
variant: Cross-over

cross-sectional study
type: Class
subclass of: Study Design
editor: Ashleigh Faith
me SH code: D003430
definition: Studies in which the presence or absence of disease or other health-related variables are determined in each member of the study population or in a representative sample at one particular time. [MeSH_2014]
variant: cross sectional design
variant: cross sectional designs
variant: cross sectional studies
variant: cross sectional study
variant: cross sectional trial
variant: cross sectional trials
variant: cross-sectional design
variant: cross-sectional designs
variant: cross-sectional research
variant: cross-sectional studies
variant: cross-sectional survey
variant: cross-sectional trial
variant: cross-sectional trials
legacy term: Epidemiologic methods [1975-1989]
incompatible with: Longitudinal studies
UMLS CUI: C0010362
semantic type: Research Activity
definition: A study in which participants are examined at only a single time for characteristics of a disease. [NCIT_14.05d]
NCI thesaurus code: C53310

database study
type: Class
subclass of: Study Design
variant: data base design
variant: data base designs
variant: data base studies
variant: data base study
variant: data base trial
variant: data base trials
variant: database design
variant: database designs
variant: database studies
variant: database trial
variant: database trials

descriptive study
type: Class
subclass of: Study Design
variant: descriptive design
variant: descriptive designs
variant: descriptive research
variant: descriptive studies
variant: descriptive trial
variant: descriptive trials

diagnostic study
type: Class
subclass of: Study Design
variant: diagnostic design
variant: diagnostic designs
variant: diagnostic studies
variant: diagnostic trial
variant: diagnostic trials

diagnostic test accuracy study
type: Class
subclass of: diagnostic study
variant: diagnostic test accuracy studies

dictionary
type: Class
subclass of: Publication Type
variant: dictionaries
definition: A reference book containing a list of words - usually in alphabetical order - giving information about form, pronunciation, etymology, grammar, and meaning. A foreign-language dictionary is an alphabetical list of words of one language with their meaning and equivalents in another language. [MeSH_2014]
semantic type: Intellectual Product
UMLS CUI: C0012108
editor: Ashleigh Faith
me SH code: D016437
NCI thesaurus code: C49461
semantic type: Classification
semantic type: Manufactured Object
variant: Terminology

directory
type: Class
subclass of: Publication Type
variant: directories
variant: published directories
variant: published directory
editor: Ashleigh Faith
semantic type: Manufactured Object
variant: Registries
UMLS CUI: C0920318
NCI thesaurus code: C49057
definition: A document that points out the location of people, places, or objects. [NCIT_14.05d]
semantic type: Intellectual Product
variant: Registers
me SH code: D016435
variant: Registry
variant: Register
definition: Work consisting of an alphabetical or classified list of names, organizations, subjects, etc., giving usually titles, addresses, affiliations, and other professional data. [MeSH_2014]

disease frequency survey
type: Class
subclass of: survey
variant: disease frequency surveys
variant: surveys, disease frequency

double blind clinical design
type: Class
subclass of: double blind design
variant: double blind clinical designs
variant: double blind clinical studies
variant: double blind clinical study
variant: double blind clinical trial
variant: double blind clinical trials
variant: double-blind clinical design
variant: double-blind clinical designs
variant: double-blind clinical studies
variant: double-blind clinical study
variant: double-blind clinical trial
variant: double-blind clinical trials
me SH code: D004311
editor: Ashleigh Faith
semantic type: Research Activity

double blind comparison
type: Class
subclass of: double blind design
variant: double-blind comparison
me SH code: D004311
semantic type: Research Activity
editor: Ashleigh Faith

double blind crossover design
type: Class
subclass of: cross-over design
subclass of: double blind design
variant: double blind crossover designs
variant: double blind crossover studies
variant: double blind crossover study
variant: double blind crossover trial
variant: double blind crossover trials
variant: double-blind crossover design
variant: double-blind crossover designs
variant: double-blind crossover studies
variant: double-blind crossover study
variant: double-blind crossover trial
variant: double-blind crossover trials
semantic type: Research Activity
me SH code: D004311
editor: Ashleigh Faith

double blind design
type: Class
subclass of: Study Design
variant: double blind designs
variant: double blind studies
variant: double blind study
variant: double blind test
variant: double blind tests
variant: double blind trial
variant: double blind trials
variant: double masked design
variant: double masked designs
variant: double masked studies
variant: double masked study
variant: double masked trial
variant: double masked trials
variant: double-blind design
variant: double-blind designs
variant: double-blind studies
variant: double-blind study
variant: double-blind test
variant: double-blind tests
variant: double-blind trial
variant: double-blind trials
variant: double-masked design
variant: double-masked designs
variant: double-masked studies
variant: double-masked study
variant: double-masked trial
variant: double-masked trials
me SH code: D004311
variant: double-blind method
semantic type: Research Activity
definition: A method of studying a drug or procedure in which both the subjects and investigators are kept unaware of who is actually getting which specific treatment. [Double-blind method | MeSH_2014]
editor: Ashleigh Faith
variant: double blind method

double blind randomized controlled trial
type: Class
subclass of: double blind design
subclass of: randomized controlled trial
variant: double blinded randomised controlled design
variant: double blinded randomised controlled designs
variant: double blinded randomised controlled studies
variant: double blinded randomised controlled study
variant: double blinded randomised controlled trial
variant: double blinded randomised controlled trials
variant: double blinded randomized controlled design
variant: double blinded randomized controlled designs
variant: double blinded randomized controlled studies
variant: double blinded randomized controlled study
variant: double blinded randomized controlled trials
variant: double blinded rct
variant: double blinded rcts
variant: double-blinded randomised controlled design
variant: double-blinded randomised controlled designs
variant: double-blinded randomised controlled studies
variant: double-blinded randomised controlled study
variant: double-blinded randomised controlled trial
variant: double-blinded randomised controlled trials
variant: double-blinded randomized controlled design
variant: double-blinded randomized controlled designs
variant: double-blinded randomized controlled studies
variant: double-blinded randomized controlled study
variant: double-blinded randomized controlled trial
variant: double-blinded randomized controlled trials
variant: double-blinded rct
variant: double-blinded rcts
legacy term: Research design [1977-1989]
me SH code: D004311
variant: double blinded randomized controlled trial
editor: Ashleigh Faith
definition: A method of studying a drug or procedure in which both the subjects and investigators are kept unaware of who is actually getting which specific treatment. [Double-blind method | MeSH_2014]
semantic type: Research Activity

duplicate publication
type: Class
subclass of: Publication Type
variant: duplicate publications
definition: Work consisting of an article or book of identical or nearly identical material published simultaneously or successively to material previously published elsewhere, without acknowledgment of the prior publication. [MeSH_2014]
editor: Ashleigh Faith
semantic type: Intellectual Product
me SH code: D016438

ecological cross-sectional study
type: Class
subclass of: cross-sectional study
subclass of: ecological study
variant: ecological cross sectional design
variant: ecological cross sectional designs
variant: ecological cross sectional studies
variant: ecological cross sectional study
variant: ecological cross sectional trial
variant: ecological cross sectional trials
variant: ecological cross-sectional design
variant: ecological cross-sectional designs
variant: ecological cross-sectional studies
variant: ecological cross-sectional trial
variant: ecological cross-sectional trials

ecological study
type: Class
subclass of: Study Design
variant: ecological design
NCI thesaurus code: C53307
definition: a statistical study exploring hypotheses by comparing groups, rather than individuals, e.g., comparing rates of breast cancer and levels of fat intake by country. [Dorland's illustrated medical dictionary_2011]
variant: population-based study
variant: ecological designs
variant: ecologic studies
variant: ecologic study
variant: ecological studies
UMLS CUI: C1709599
editor: Tanja Bekhuis
variant: population based study

editorial
type: Class
subclass of: Publication Type
variant: editorials
me SH code: D016421
definition: Work consisting of a statement of the opinions, beliefs, and policy of the editor or publisher of a journal, usually on current matters of medical or scientific significance to the medical community or society at large. The editorials published by editors of journals representing the official organ of a society or organization are generally substantive. [MeSH_2014]
editor: Ashleigh Faith
semantic type: Intellectual Product

epidemiological design
type: Class
subclass of: Study Design
editor: Ashleigh Faith
me SH code: D016021
semantic type: Research Activity
definition: Studies designed to examine associations, commonly, hypothesized causal relations. They are usually concerned with identifying or measuring the effects of risk factors or exposures. [MeSH_2014]
variant: epidemiologic design
variant: epidemiologic designs
variant: epidemiologic studies
variant: epidemiologic study
variant: epidemiologic trial
variant: epidemiologic trials
variant: epidemiological designs
variant: epidemiological studies
variant: epidemiological study
variant: epidemiological trial
variant: epidemiological trials
variant: studies, epidemiologic
definition: Epidemiological methods involve sophisticated statistics and higher mathematics. These methods allow epidemiologists to address issues like non-experimental studies of mechanistic questions in disease etiology, including studies of the impact of the social position of individuals in different social contexts.[Epidemiological method | NCIT_14.05d]
variant: Epidemiological Method
variant: Epidemiology, Method
NCI thesaurus code: C16555
UMLS CUI: C0014503
variant: Epidemiological Technique

erratum
type: Class
subclass of: Publication Type
variant: Corrigenda
variant: Published Erratum
definition: erratum = Item reporting an error, correction or retraction of a previously published paper [Emtree Scope Note, April 14, 2015]
me SH code: D016425
variant: errata
editor: Tanja Bekhuis
definition: Work consisting of an acknowledgment of an error, issued by a publisher, editor, or author. It customarily cites the source where the error occurred, giving complete bibliographic data for retrieval. In the case of books and monographs, author, title, imprint, paging, and other helpful references will be given; in the case of journal articles, the author, title, paging, and journal reference will be shown. An erratum notice is variously cited as Errata or Corrigenda. [MeSH_2015]
date: April 14, 2015

evaluation
type: Class
subclass of: Study Design
editor: Tanja Bekhuis
variant: evaluation studies
variant: evaluation study
variant: evaluation design
variant: evaluation designs
me SH code: D005069
definition: Studies determining the effectiveness or value of processes, personnel, and equipment, or the material on conducting such studies. [Evaluation Studies as Topic | MeSH_2015]
variant: evaluations
date: November 18, 2014
semantic type: Research Activity

evidence report
type: Class
subclass of: literature review
variant: evidence reports
variant: report of evidence

evidence report
type: Class
subclass of: literature review
variant: evidence reports
variant: report of evidence

ex post facto design
type: Class
subclass of: retrospective study
variant: ex post facto designs
variant: ex post facto studies
variant: ex post facto study
variant: ex post facto trial
variant: ex post facto trials

experimental design
type: Class
subclass of: Study Design
variant: experimental designs
variant: experimental studies
variant: experimental study
variant: experimental trial
variant: experimental trials
variant: Experimental Design
NCI thesaurus code: C15320
legacy term: Study Design
definition: Describes the role the study plays in determining the interventions a subject receives. [NCIT_14.05d] [Contributing_Source_CDISC]
definition: A plan detailing how a study will be performed in order to represent the phenomenon under examination, to answer the research questions that have been asked, and defining the methods of data analysis. Study design is driven by research hypothesis being posed, study subject/population/sample available, logistics/resources: technology, support, networking, collaborative support, etc. [Study design | NCIT_14.05d]
semantic type: Research Activity
variant: Experiment Design
UMLS CUI: C0035171

face-to-face interview
type: Class
subclass of: interview
variant: face-to-face interviews

factorial design
type: Class
subclass of: Study Design
variant: factorial designs
variant: factorial studies
variant: factorial study
variant: factorial trial
variant: factorial trials
variant: Factorial
definition: Two or more interventions, each alone and in combination, are evaluated in parallel against a control group. [NCIT_14.05d] [Contributing_Source_CDISC]
UMLS CUI: C2826344
NCI thesaurus code: C82638
semantic type: Research Activity
definition: A type of clinical study in which two or more treatments are given alone and in combination, such that all possible combinations are represented across the treatment arms, and are compared in parallel against the study control group. [NCIT_14.05d]
editor: Ashleigh Faith

feasibility study
type: Class
subclass of: Study Design
variant: feasibility trial
variant: feasibility studies
variant: feasibility designs
variant: feasibility design
variant: feasibility trials

festschrift
type: Class
subclass of: Publication Type
variant: festschriften
definition: Work consisting of a collection of essays or other writings contributed by students, teachers, colleagues, and associates to honor a person or institution, usually on the occasion of an anniversary celebration or other event of importance. [MeSH_2014]
legacy term: Historical Biography (1966-1990)
legacy term: Current Biog-Obit (1966-1990)
variant: Festschriften
me SH code: D016221
semantic type: Intellectual Product
editor: Ashleigh Faith

field survey
type: Class
subclass of: survey
semantic type: Research Activity
editor: Tanja Bekhuis
definition: A descriptive or analytic study of risk factors or disease determinants in populations. Most epidemiologic and some genetic studies fit within this category. [NCIT_14.08d]
NCI thesaurus code: C39404
UMLS CUI: C1517184
variant: field surveys

file review
type: Class
subclass of: records review
variant: review of files

focus group
type: Class
subclass of: Study Design
definition: A method of data collection and a qualitative research tool in which a small group of individuals are brought together and allowed to interact in a discussion of their opinions about topics, issues, or questions. [MeSH_2014]
editor: Ashleigh Faith
me SH code: D017144
semantic type: Group
variant: focus groups

follow-up study
type: Class
subclass of: longitudinal design

government publication
type: Class
subclass of: Publication Type
variant: government publications
variant: Government Document
me SH code: D022903
editor: Ashleigh Faith
semantic type: Intellectual Product
definition: Works consisting of documents issued by local, regional, or national governments or by their agencies or subdivisions. [MeSH_2014]
variant: Government Documents
semantic type: Manufactured Object

group randomized design
type: Class
subclass of: randomized design
variant: group randomised design
variant: group randomised designs
variant: group randomised studies
variant: group randomised study
variant: group randomised trial
variant: group randomised trials
variant: group randomized designs
variant: group randomized studies
variant: group randomized study
variant: group randomized trial
variant: group randomized trials

head to head design
type: Class
subclass of: Study Design
variant: head to head designs
variant: head to head studies
variant: head to head study
variant: head to head trial
variant: head to head trials
variant: head-to-head design
variant: head-to-head designs
variant: head-to-head studies
variant: head-to-head study
variant: head-to-head trial
variant: head-to-head trials

health care survey
type: Class
subclass of: survey
variant: healthcare surveys
variant: health care surveys
semantic type: Research Activity
definition: Statistical measures of utilization and other aspects of the provision of health care services including hospitalization and ambulatory care. [Health care surveys | MeSH_2014]
editor: Tanja Bekhuis
variant: healthcare survey
me SH code: D019538

health survey
type: Class
subclass of: survey
definition: A systematic collection of factual data pertaining to health and disease in a human population within a given geographic area. [Health surveys | MeSH_2014]
variant: health surveys
semantic type: Research Activity
editor: Tanja Bekhuis
me SH code: D006306

historical article
type: Class
subclass of: article
variant: historical articles
me SH code: D016456
variant: historical survey
editor: Ashleigh Faith
semantic type: Intellectual Product
definition: An article or portion of an article giving an account of past events or circumstances significant in a field of study, a profession, a discovery, an invention, etc. The concept of history is very wide, ranging from the dawn of time to the present. This publication type is often checked in conjunction with BIOGRAPHY. [MeSH_2014]

historically controlled design
type: Class
subclass of: controlled design
variant: historically controlled designs
variant: historically controlled studies
variant: historically controlled study
variant: historically controlled trial
variant: historically controlled trials
variant: historical control trial
variant: historical control studies
date: November 7, 2014
semantic type: Quantitative Concept
definition: A study that compares a group of participants receiving an intervention with a similar group from the past who did not. [Historically Controlled Study | MeSH_2015]
semantic type: Research Activity
variant: historical control designs
variant: historical control study
editor: Tanja Bekhuis
variant: historical control design
me SH code: D065386
variant: historical control trials

hospital-based case control design
type: Class
subclass of: case control design
variant: hospital based case control design
variant: hospital based case control studies
variant: hospital based case control study
variant: hospital based case control trial
variant: hospital based case-control design
variant: hospital based case-control studies
variant: hospital based case-control study
variant: hospital based case-control trial
variant: hospital-based case control designs
variant: hospital-based case control studies
variant: hospital-based case control study
variant: hospital-based case control trials
variant: hospital-based case-control designs
variant: hospital-based case-control studies
variant: hospital-based case-control study
variant: hospital-based case-control trials

human study
type: Class
subclass of: Study Design
variant: human experiment
variant: human experiments
variant: human studies

in vitro study
type: Class
subclass of: Study Design
variant: in vitro studies
variant: in vitro designs
variant: in vitro design

in vivo study
type: Class
subclass of: Study Design
variant: in vivo studies
variant: in vivo design
variant: in vivo designs

incidence study
type: Class
subclass of: cohort study
variant: incidence studies

index
type: Class
subclass of: Publication Type
variant: indices
variant: indexes

interactive tutorial
type: Class
subclass of: Publication Type
variant: interactive media
variant: interactive tutorials
me SH code: D054710
variant: Interactive Media
definition: Video recordings or other files in which the progress of the instruction or content is determined by user response. [MeSH_2014]
editor: Ashleigh Faith
semantic type: Intellectual Product

interrupted time series design
type: Class
subclass of: time series design
variant: interrupted time series designs
variant: interrupted time series studies
variant: interrupted time series study
variant: interrupted time series trial
variant: interrupted time series trials
variant: interrupted time series analyses
semantic type: Quantitative Concept
variant: ITS study
me SH code: D065186
variant: interrupted time series
definition: A study that uses observations at multiple time points before and after an intervention (the "interruption"), in an attempt to detect whether the intervention has had an effect significantly greater than any underlying trend over time. [Interrupted Time Series Analysis | MeSH_2015]
semantic type: Research Activity
date: November 7, 2014
editor: Tanja Bekhuis
variant: interrupted time series analysis
variant: ITS studies

interrupted time series with comparison group
type: Class
subclass of: interrupted time series design
variant: interrupted time series with comparison groups

interrupted time series without comparison group
type: Class
subclass of: interrupted time series design
variant: interrupted time series without comparison groups

interview
type: Class
subclass of: Publication Type
variant: interviewing
variant: interviews
semantic type: Research Activity
me SH code: D017203
semantic type: Intellectual Product
definition: Work consisting of a conversation with an individual regarding his or her background and other personal and professional details, opinions on specific subjects posed by the interviewer, etc. [MeSH_2014]
NCI thesaurus code: C16751
variant: oral history
definition: A conversation with an individual regarding his or her background and other personal and professional details, opinions on specific subjects posed by the interviewer, etc. [NCIT_14.05d]
UMLS CUI: C0021822
semantic type: Occupational Activity
editor: Ashleigh Faith

interview
type: Class
subclass of: Study Design
variant: interview study
me SH code: D017203
semantic type: Research Activity
variant: interviews
definition: Work consisting of a conversation with an individual regarding his or her background and other personal and professional details, opinions on specific subjects posed by the interviewer, etc. [MeSH_2014]
semantic type: Intellectual Product
variant: oral history
NCI thesaurus code: C16751
variant: interviewing
variant: interview studies
editor: Ashleigh Faith
semantic type: Occupational Activity
definition: A conversation with an individual regarding his or her background and other personal and professional details, opinions on specific subjects posed by the interviewer, etc. [NCIT_14.05d]
UMLS CUI: C0021822

introductory journal article
type: Class
subclass of: journal article
variant: introductory journal articles
variant: prefatory journal article
variant: prefatory journal articles
variant: Prefatory Journal Article
definition: Prefactory summary to a special issue or section of a journal devoted to a specific topic. This introductory text can be of varying length and substance. [MeSH_2014]
me SH code: D054711
semantic type: Intellectual Product
editor: Ashleigh Faith

journal article
type: Class
subclass of: article
variant: journal articles
definition: The predominant publication type for articles and other items indexed for NLM databases. [MeSH_2015]
semantic type: Intellectual Product
date: November 13, 2014
me SH code: D016428
editor: Tanja Bekhuis

lecture
type: Class
subclass of: Publication Type
variant: lectures
me SH code: D019531
semantic type: Intellectual Product
editor: Ashleigh Faith
definition: Works consisting of speeches read or delivered before an audience or class, especially for instruction or to set forth some subject. They are differentiated from ADDRESSES [PUBLICATION TYPE] which are less didactic and more informational, entertaining, inspirational, or polemic. (From Random House Unabridged Dictionary, 2d ed) [MeSH_2014]

legislation
type: Class
subclass of: Publication Type
variant: legislations
variant: Legal case
me SH code: D020485
variant: Legal cases
definition: Works consisting of the text of proposed or enacted legislation that may be in the form of bills, laws, statutes, ordinances, or government regulations.CATALOG: use when 20% or more of the content consists of the text of laws, statutes, ordinances, or government regulations. Do not use for works that are merely discussion of law, etc. [MeSH_2014]
semantic type: Intellectual Product
editor: Ashleigh Faith

letter
type: Class
subclass of: Publication Type
variant: Collected Correspondence
definition: A written message addressed to a person or organization. [NCIT_14.05d] [Contributing_Source_ FDA]
definition: Work consisting of written or printed communication between individuals or between persons and representatives of corporate bodies. The correspondence may be personal or professional. In medical and other scientific publications the letter is usually from one or more authors to the editor of the journal or book publishing the item being commented upon or discussed. LETTER is often accompanied by COMMENT. [MeSH_2014]
semantic type: Intellectual Product
semantic type: Manufactured Object
UMLS CUI: C1096774
editor: Ashleigh Faith
me SH code: D016422
NCI thesaurus code: C70805

letter to the editor
type: Class
subclass of: letter
variant: letters to the editor

literature review
type: Class
subclass of: Publication Type
variant: review, academic
me SH code: D016454
variant: review literature
variant: reviews
variant: review of literature
variant: review
variant: review of reported cases
variant: literature reviews
definition: An article or book published after examination of published material on a subject. It may be comprehensive to various degrees and the time range of material scrutinized may be broad or narrow, but the reviews most often desired are reviews of the current literature. The textual material examined may be equally broad and can encompass, in medicine specifically, clinical material as well as experimental research or case reports. State-of-the-art reviews tend to address more current matters. [MeSH_2014]
definition: Significant review of original research. [Emtree_2014]
editor: Ashleigh Faith
variant: review, multicase
semantic type: Intellectual Product

longitudinal design
type: Class
subclass of: Study Design
variant: longitudinal designs
variant: longitudinal evaluation
variant: longitudinal studies
variant: longitudinal study
variant: longitudinal survey
variant: longitudinal trial
variant: longitudinal trials
definition: Studies in which variables relating to an individual or group of individuals are assessed over a period of time. [MeSH_2014]
semantic type: Research Activity
me SH code: D008137
editor: Ashleigh Faith
semantic type: Quantitative Concept
legacy term: Epidemiologic Methods [1966-1974]
definition: a study in which participants, processes, or systems are studied over time, with data being collected at multiple intervals. The two main types are prospective s. and retrospective s. Cf. cross-sectional study [Emtree_2014] [Doralnd's Medaical Dictionary_2011]

matched case control design
type: Class
subclass of: case control design
variant: matched case control
variant: matched case control designs
variant: matched case control studies
variant: matched case control study
variant: matched case control trial
variant: matched case control trials
variant: matched case-control design
variant: matched case-control designs
variant: matched case-control studies
variant: matched case-control study
variant: matched case-control trial
variant: matched case-control trials
editor: Ashleigh Faith
me SH code: D016022
semantic type: Research Activity

medical audit
type: Class
subclass of: records review
variant: Audits, Medical
variant: Med Audit
semantic type: Health Care Activity
legacy term: Hospital Administration [1966-1967]
variant: Audit, Medical
me SH code: D008485
editor: Ashleigh Faith
definition: A detailed review and evaluation of selected clinical records by qualified professional personnel for evaluating quality of medical care. [MeSH_2014]
variant: Medical Audits

medical record review
type: Class
subclass of: records review
variant: medical records review
variant: review of medical records

meta-analysis
type: Class
subclass of: Publication Type
variant: meta analyses
date: January 7, 2015
editor: Tanja Bekhuis
variant: meta analysis
variant: metaanalyses
variant: meta-analyses
semantic type: Intellectual Product
me SH code: D017418
definition: Works consisting of studies using a quantitative method of combining the results of independent studies (usually drawn from the published literature) and synthesizing summaries and conclusions which may be used to evaluate therapeutic effectiveness, plan new studies, etc. It is often an overview of clinical trials. It is usually called a meta-analysis by the author or sponsoring body and should be differentiated from reviews of literature. [MeSH_2015]
variant: metaanalysis

meta-analysis
type: Class
subclass of: Study Design
editor: Ashleigh Faith
variant: analysis, meta
variant: meta analysis
variant: metaanalysis
variant: meta-analyses
UMLS CUI: C0920317
semantic type: Research Activity
variant: metaanalyses
definition: A set of statistical procedures designed to accumulate experimental and correlational results across independent studies that address a related set of research questions. [NCIT_14.05d]
definition: Used for original reports evaluating medical interventions by the statistical analysis of a large collection of analysis results from individual studies, for the purpose of integrating the findings; not limited to clinical trials. [Emtree_2014]
variant: meta analyses
definition: The formal evaluation of the quantitative evidence from two or more trials bearing on the same question. NOTE: This most commonly involves the statistical combination of summary statistics from the various trials, but the term is sometimes also used to refer to the combination of the raw data. [from ICH E9 Glossary] [NCIT_14.05d] [Contributing_Source_CDISC]
NCI thesaurus code: C17886

meta analysis of individual participant data
type: Class
subclass of: meta-analysis
variant: individual patient data meta analysis
variant: individual patient data meta-analysis
variant: individual patient data metaanalysis
variant: individual patient data review
variant: ipd meta analysis
variant: ipd meta-analysis
variant: ipd metaanalysis
variant: ipd review
variant: meta analysis of individual patient data
variant: meta-analysis of individual participant data
variant: meta-analysis of individual patient data
variant: metaanalysis of individual participant data
variant: metaanalysis of individual patient data
variant: mipd
variant: review of individual patient data

multiple case study
type: Class
subclass of: case study
variant: multiple case report

narrative review
type: Class
subclass of: literature review
variant: narrative reviews

narrative review
type: Class
subclass of: literature review
variant: narrative reviews

natural experiment
type: Class
subclass of: Study Design
variant: natural experiments
date: December 3, 2014
editor: Tanja Bekhuis
definition: A naturally occurring situation that has many of the trappings of a formal laboratory experiment in that one can identify factors that function as independent variables although they are not controlled in the usual sense. For example, one could study the role of schooling in vocabulary development in children by comparing the number of new words learned during the summer with the number learned during the months just preceding and following. [Penguin Dictionary of Psychology_2009]

nested case control design
type: Class
subclass of: case control design
variant: nested case control designs
variant: nested case control studies
variant: nested case control study
variant: nested case control trial
variant: nested case control trials
variant: nested case-control design
variant: nested case-control designs
variant: nested case-control studies
variant: nested case-control study
variant: nested case-control trial
variant: nested case-control trials
semantic type: Research Activity
UMLS CUI: C0027775
NCI thesaurus code: C48202
editor: Ashleigh Faith
definition: A study in which a group or cohort of individuals is followed for a certain length of time or until a specific outcome is reached. Studies of this type incorporate the strengths of both cohort and case-control studies but eliminates a portion of the methodologic challenges inherent in both types of studies. [NCIT_14.05d]

non-comparative design
type: Class
subclass of: Study Design
variant: non-comparative designs
variant: non-comparative studies
variant: non-comparative study
variant: non-comparative trial
variant: non-comparative trials
variant: noncomparative design
variant: noncomparative designs
variant: noncomparative studies
variant: noncomparative study
variant: noncomparative trial
variant: noncomparative trials

nonconcurrent cohort study
type: Class
subclass of: cohort study
variant: non-concurrent cohort design
variant: non-concurrent cohort designs
variant: non-concurrent cohort studies
variant: non-concurrent cohort study
variant: non-concurrent cohort trial
variant: non-concurrent cohort trials
variant: nonconcurrent cohort design
variant: nonconcurrent cohort designs
variant: nonconcurrent cohort studies
variant: nonconcurrent cohort trial
variant: nonconcurrent cohort trials

non-controlled design
type: Class
subclass of: Study Design
variant: non-controlled designs
variant: non-controlled studies
variant: non-controlled study
variant: non-controlled trial
variant: non-controlled trials
variant: noncontrolled design
variant: noncontrolled designs
variant: noncontrolled studies
variant: noncontrolled study
variant: noncontrolled trial
variant: noncontrolled trials
variant: uncontrolled design
variant: uncontrolled designs
variant: uncontrolled studies
variant: uncontrolled study
variant: uncontrolled trial
variant: uncontrolled trials

non-equivalent control group design
type: Class
subclass of: non-randomized clinical trial
variant: non-equivalent control group designs

non-experimental design
type: Class
subclass of: Study Design
variant: non-experimental designs
variant: non-experimental studies
variant: non-experimental study
variant: non-experimental trial
variant: non-experimental trials
variant: nonexperimental design
variant: nonexperimental designs
variant: nonexperimental studies
variant: nonexperimental study
variant: nonexperimental trial
variant: nonexperimental trials

non-randomized clinical trial
type: Class
subclass of: clinical trial
variant: nonrandomised clinical trial
variant: clinical trials, non-randomized
variant: nonrandomised clinical trials
variant: clinical trial, non-randomised
variant: clinical trials, nonrandomized
variant: clinical trials, nonrandomised
variant: clinical trials, non-randomised
variant: non-randomised clinical trials
variant: nonrandomized clinical trial
variant: non-randomized clinical trials
variant: clinical trial, non-randomized
variant: clinical trial, nonrandomized
variant: non-randomised clinical trial
variant: nonrandomized clinical trials
variant: clinical trial, nonrandomised

non-randomized comparative design
type: Class
subclass of: comparative study
variant: non-randomised comparative design
variant: non-randomised comparative designs
variant: non-randomised comparative studies
variant: non-randomised comparative study
variant: non-randomised comparative trial
variant: non-randomised comparative trials
variant: non-randomized comparative designs
variant: non-randomized comparative studies
variant: non-randomized comparative study
variant: non-randomized comparative trial
variant: non-randomized comparative trials
variant: nonrandomised comparative design
variant: nonrandomised comparative designs
variant: nonrandomised comparative studies
variant: nonrandomised comparative study
variant: nonrandomised comparative trial
variant: nonrandomised comparative trials
variant: nonrandomized comparative design
variant: nonrandomized comparative designs
variant: nonrandomized comparative studies
variant: nonrandomized comparative study
variant: nonrandomized comparative trial
variant: nonrandomized comparative trials

non-randomized controlled design
type: Class
subclass of: controlled design
variant: non-randomised controlled design
variant: non-randomised controlled designs
variant: non-randomised controlled studies
variant: non-randomised controlled study
variant: non-randomised controlled trial
variant: non-randomised controlled trials
variant: non-randomized controlled designs
variant: non-randomized controlled studies
variant: non-randomized controlled study
variant: non-randomized controlled trial
variant: non-randomized controlled trials
variant: nonrandomised controlled design
variant: nonrandomised controlled designs
variant: nonrandomised controlled studies
variant: nonrandomised controlled study
variant: nonrandomised controlled trial
variant: nonrandomised controlled trials
variant: nonrandomized controlled design
variant: nonrandomized controlled designs
variant: nonrandomized controlled studies
variant: nonrandomized controlled study
variant: nonrandomized controlled trial
variant: nonrandomized controlled trials
date: November 7, 2014
me SH code: D065228
editor: Tanja Bekhuis
semantic type: Research Activity
semantic type: Quantitative Concept
definition: A study where participants are assigned to a treatment, procedure, or intervention my methods that are not random. Non-randomized clinical trials are sometimes referred to as quasi-experimental clinical trials or non-equivalent control group designs. [Non-Randomized Controlled Trials as Topic | MeSH_2015]

non-randomized cross-over design
type: Class
subclass of: cross-over design
variant: non-randomised cross-over design
variant: non-randomised cross-over designs
variant: non-randomised cross-over studies
variant: non-randomised cross-over study
variant: non-randomised cross-over trial
variant: non-randomised cross-over trials
variant: non-randomised crossover design
variant: non-randomised crossover designs
variant: non-randomised crossover studies
variant: non-randomised crossover study
variant: non-randomised crossover trial
variant: non-randomised crossover trials
variant: non-randomized cross-over designs
variant: non-randomized cross-over studies
variant: non-randomized cross-over study
variant: non-randomized cross-over trial
variant: non-randomized cross-over trials
variant: non-randomized crossover design
variant: non-randomized crossover designs
variant: non-randomized crossover studies
variant: non-randomized crossover study
variant: non-randomized crossover trial
variant: non-randomized crossover trials
variant: nonrandomised cross-over design
variant: nonrandomised cross-over designs
variant: nonrandomised cross-over studies
variant: nonrandomised cross-over study
variant: nonrandomised cross-over trial
variant: nonrandomised cross-over trials
variant: nonrandomised crossover design
variant: nonrandomised crossover designs
variant: nonrandomised crossover studies
variant: nonrandomised crossover study
variant: nonrandomised crossover trial
variant: nonrandomised crossover trials
variant: nonrandomized cross-over design
variant: nonrandomized cross-over designs
variant: nonrandomized cross-over studies
variant: nonrandomized cross-over study
variant: nonrandomized cross-over trial
variant: nonrandomized cross-over trials
variant: nonrandomized crossover design
variant: nonrandomized crossover designs
variant: nonrandomized crossover studies
variant: nonrandomized crossover study
variant: nonrandomized crossover trial
variant: nonrandomized crossover trials

non-randomized design
type: Class
subclass of: Study Design
variant: non-randomised design
variant: non-randomised designs
variant: non-randomised studies
variant: non-randomised study
variant: non-randomised trial
variant: non-randomised trials
variant: non-randomized designs
variant: non-randomized studies
variant: non-randomized study
variant: non-randomized trial
variant: non-randomized trials
variant: nonrandomised design
variant: nonrandomised designs
variant: nonrandomised studies
variant: nonrandomised study
variant: nonrandomised trial
variant: nonrandomised trials
variant: nonrandomized design
variant: nonrandomized designs
variant: nonrandomized studies
variant: nonrandomized study
variant: nonrandomized trial
variant: nonrandomized trials

nonconsecutive case series
type: Class
subclass of: case series
UMLS CUI: C2985409
semantic type: Research Activity
definition: A clinical study that includes some, but not all, of the eligible patients identified by the researchers during the study registration period. This type of study does not usually have a control group. [NCIT_14.08d]
NCI thesaurus code: C93042

observational study
type: Class
subclass of: Study Design
variant: observation design
variant: observation designs
variant: observation studies
variant: observation study
variant: observation trial
variant: observation trials
variant: observational design
variant: observational designs
variant: observational studies
variant: observational trial
variant: observational trials
definition: Studies in which biomedical and/or health outcomes are assessed in pre-defined groups of individuals. Subjects in the study may receive diagnostic, therapeutic, or other interventions, but the investigator does not assign specific interventions to the subjects of the study. [NCIT_14.05d] [Contributing_Source_CDISC]
definition: A type of study in which individuals are observed or certain outcomes are measured. No attempt is made to affect the outcome (for example, no treatment is given). [NCIT_14.05d]
UMLS CUI: C1518527
definition: Studies among cancer patients and healthy populations that involve no intervention or alteration in the status of the participants. [NCIT_14.05d]
NCI thesaurus code: C16084
semantic type: Research Activity

open clinical design
type: Class
subclass of: open design
variant: open clinical designs
variant: open clinical studies
variant: open clinical study
variant: open clinical trial
variant: open clinical trials

open design
type: Class
subclass of: Study Design
variant: open designs
variant: open studies
variant: open study
variant: open trial
variant: open trials

open label clinical design
type: Class
subclass of: open label design
variant: open label clinical designs
variant: open label clinical studies
variant: open label clinical study
variant: open label clinical trial
variant: open label clinical trials
variant: open-label clinical design
variant: open-label clinical designs
variant: open-label clinical studies
variant: open-label clinical study
variant: open-label clinical trial
variant: open-label clinical trials

open label design
type: Class
subclass of: open design
variant: open label designs
variant: open label studies
variant: open label study
variant: open label trial
variant: open label trials
variant: open-label design
variant: open-label designs
variant: open-label studies
variant: open-label study
variant: open-label trial
variant: open-label trials

open label randomized controlled trial
type: Class
subclass of: open label design
subclass of: randomized controlled trial
variant: open label randomised controlled design
variant: open label randomised controlled designs
variant: open label randomised controlled studies
variant: open label randomised controlled study
variant: open label randomised controlled trial
variant: open label randomised controlled trials
variant: open label randomized controlled design
variant: open label randomized controlled designs
variant: open label randomized controlled studies
variant: open label randomized controlled study
variant: open label randomized controlled trials
variant: open label rct
variant: open label rcts
variant: open-label randomised controlled design
variant: open-label randomised controlled designs
variant: open-label randomised controlled studies
variant: open-label randomised controlled study
variant: open-label randomised controlled trial
variant: open-label randomised controlled trials
variant: open-label randomized controlled design
variant: open-label randomized controlled designs
variant: open-label randomized controlled studies
variant: open-label randomized controlled study
variant: open-label randomized controlled trial
variant: open-label randomized controlled trials
variant: open-label rct
variant: open-label rcts
variant: open label randomized controlled trial

opinion paper
type: Class
subclass of: Publication Type
variant: opinion papers
variant: discussion papers
variant: opinion piece
variant: opinion pieces
variant: discussion pieces
variant: discussion piece
variant: discussion paper

overview of reviews
type: Class
subclass of: literature review
variant: overview reviews
variant: overview review

overview of reviews
type: Class
subclass of: literature review
variant: overview reviews
variant: overview review

parallel design
type: Class
subclass of: Study Design
variant: parallel designs
variant: parallel studies
variant: parallel study
variant: parallel trial
variant: parallel trials
UMLS CUI: C2826345
definition: Participants are assigned to one of two or more arms in parallel for the duration of the study. [NCIT_14.05d] [Contributing_Source_CDISC]
NCI thesaurus code: C82639
definition: A type of clinical study in which subjects are assigned to one of two treatment arms at the beginning of the trial and continue in that arm throughout the length of the trial. Study subjects are only exposed to the treatment that is assigned to the particular study arm they are enrolled in. [NCIT_14.05d]
semantic type: Research Activity

patient education handout
type: Class
subclass of: Publication Type
variant: patient education handouts
me SH code: D029282
semantic type: Intellectual Product
variant: Consumer Handout
editor: Ashleigh Faith
variant: Consumer Information Handout
definition: Works consisting of a handout or self-contained informative material used to explain a procedure or a condition or the contents of a specific article in a biomedical journal and written in non-technical language for the patient or consumer. [MeSH_2014]
semantic type: Manufactured Object

periodical index
type: Class
subclass of: index
definition: Work consisting of a subject approach to the contents of a periodical issuing an annual, biennial, quinquennial, decennial, etc., index. The heading is used for the overall body of articles published by a periodical in the same sense that BIBLIOGRAPHY is useful when published as a single article. [MeSH_2014]
variant: periodical indexes
me SH code: D016453
variant: periodical indices
semantic type: Intellectual Product
editor: Ashleigh Faith
legacy term: Bibliography (1968-1989)

phase III trial
type: Class
subclass of: clinical trial

phase IIIa trial
type: Class
subclass of: clinical trial

phase IIIb trial
type: Class
subclass of: clinical trial

phase II trial
type: Class
subclass of: clinical trial

phase IIa trial
type: Class
subclass of: clinical trial
variant: trial phase IIa
variant: trial phase 2a

phase IIb trial
type: Class
subclass of: clinical trial

phase IV trial
type: Class
subclass of: clinical trial
definition: A randomized, controlled trial that is designed to evaluate the long-term safety and efficacy of a drug for a given indication. Often they are designed to study side effects that may have become apparent after the phase III study was completed. [NCIT_14.08d]
variant: Phase IV Clinical Trials
UMLS CUI: C0282462
editor: Tanja Bekhuis
variant: Clinical Trials, Phase IV
definition: Phase 4. Postmarketing (Phase 4) studies to delineate additional information about the drug's risks, benefits, and optimal use that may be requested by regulatory authorities in conjunction with marketing approval. NOTE: These studies could include, but would not be limited to, studying different doses or schedules of administration than were used in Phase 2 studies, use of the drug in other patient populations or other stages of the disease, or use of the drug over a longer period of time. [After FDA CDER Handbook, ICH E8] [Contributing Source_CDISC] [NCIT_14.08d]
variant: Phase 4 Study
semantic type: Research Activity
definition: After a treatment has been approved and is being marketed, it is studied in a phase IV trial to evaluate side effects that were not apparent in the phase III trial. Thousands of people are involved in a phase IV trial. [NCIT_14.08d]
variant: phase IV clinical trial
variant: Phase 4 Studies
NCI thesaurus code: C15603
variant: Trial Phase 4
variant: Clinical Trial, Phase IV

phase I trial
type: Class
subclass of: clinical trial
variant: Clinical Trials, Phase I
variant: Phase I Study
variant: Early-Stage Clinical Trials
variant: Phase 1 Study
UMLS CUI: C0920321
variant: Trial Phase 1
NCI thesaurus code: C15600
semantic type: Research Activity
variant: Phase I Protocol
variant: Phase I Clinical Trials

pilot study
type: Class
subclass of: Study Design
semantic type: Research Activity
variant: pilot projects
editor: Tanja Bekhuis
date: November 7, 2014
definition: Small-scale tests of methods and procedures to be used on a larger scale if the pilot study demonstrates that these methods and procedures can work. [Pilot Projects | MeSH_2015]
variant: pilot project
me SH code: D010865
variant: pilot studies

population surveillance
type: Class
subclass of: surveillance
semantic type: Health Care Activity
me SH code: D011159
semantic type: Research Activity
editor: Tanja Bekhuis
definition: Ongoing scrutiny of a population (general population, study population, target population, etc.), generally using methods distinguished by their practicability, uniformity, and frequently their rapidity, rather than by complete accuracy. [MeSH_2014]

pragmatic clinical trial
type: Class
subclass of: clinical trial
subclass of: pragmatic design
semantic type: Research Activity
variant: pragmatic clinical designs
editor: Tanja Bekhuis
variant: pragmatic clinical studies
variant: pragmatic clinical study
date: November 7, 2014
semantic type: Intellectual Product
me SH code: D065007
variant: pragmatic clinical trials
variant: pragmatic clinical design
definition: Randomized clinical trials that compare interventions in clinical settings and which look at a range of effectiveness outcomes and impacts. [MeSH_2015]

pragmatic design
type: Class
subclass of: Study Design
variant: pragmatic designs
variant: pragmatic studies
variant: pragmatic study
variant: pragmatic trial
variant: pragmatic trials

pre-and-post design
type: Class
subclass of: before-after design
variant: pre-and-post designs
variant: pre-and-post studies
variant: pre-and-post study
variant: pre-and-post trial
variant: pre-and-post trials
variant: pre-post design
variant: pre-post designs
variant: pre-post studies
variant: pre-post study
variant: pre-post tests
variant: pre-post trial
variant: pre-post trials
variant: pre-test post-test design
variant: pre-test post-test designs
variant: pre-test post-test studies
variant: pre-test post-test study
variant: pre-test post-test trial
variant: pre-test post-test trials
variant: pretest posttest design
variant: pretest posttest designs
variant: pretest posttest studies
variant: pretest posttest study
variant: pretest posttest trial
variant: pretest posttest trials

pre-test post-test control group design
type: Class
subclass of: pre-and-post design
variant: pre-test post-test control group designs
variant: pre-test post-test control group studies
variant: pre-test post-test control group study
variant: pre-test post-test control group trial
variant: pre-test post-test control group trials
variant: pretest posttest control group design
variant: pretest posttest control group designs
variant: pretest posttest control group studies
variant: pretest posttest control group study
variant: pretest posttest control group trial
variant: pretest posttest control group trials

prevalence study
type: Class
subclass of: Study Design
variant: prevalence studies
me SH code: D003430
semantic type: Research Activity
legacy term: Epidemiologic methods [1975-89]
editor: Ashleigh Faith
semantic type: Quantitative Concept

prospective case series
type: Class
subclass of: case series

prospective cohort study
type: Class
subclass of: cohort study
variant: prospective cohort design
variant: prospective cohort designs
variant: prospective cohort studies
variant: prospective cohort trial
variant: prospective cohort trials
UMLS CUI: C0033522
definition: A research study that follows over time groups of individuals who are alike in many ways but differ by a certain characteristic (for example, female nurses who smoke and those who do not smoke) and compares them for a particular outcome (such as lung cancer). [NCIT_14.05d]
editor: Ashleigh Faith
semantic type: Research Activity
NCI thesaurus code: C53308

prospective study
type: Class
subclass of: Study Design
variant: prospective studies
definition: Observation of a population for a sufficient number of persons over a sufficient number of years to generate incidence or mortality rates subsequent to the selection of the study group. [MeSH_2014]
editor: Ashleigh Faith
variant: study, prospective
definition: a longitudinal epidemiologic study in which the groups of individuals (cohorts) are selected on the basis of factors that are to be examined for their effects on outcomes, e.g., the effect of exposure to a specific risk factor on the eventual development of a particular disease, and are then followed over a period of time to determine the incidence rates of the outcomes in question in relation to the original factors. Called also cohort s.“Prospective” usually implies a cohort selected in the present and followed into the future, but the cohort method can also be applied to existing longitudinal historical data, such as insurance or medical records: a cohort is identified and classified as to exposure to some factor at some date in the past and followed up to the present to determine incidence rates of the outcome. This is called a historical prospective study, prospective study of past data, or retrospective cohort study. [Emtree_2014] [ Dorland's Medical Dictionary_2011]
semantic type: Research Activity
me SH code: D011446
variant: prospective method

psychometric study
type: Class
subclass of: Study Design
variant: psychometric design
variant: psychometric designs
variant: psychometric studies
variant: psychometric trial
variant: psychometric trials
editor: Tanja Bekhuis
definition: [A study based on ... ] The science of measuring "psychological" aspects of a person such as knowledge, skills, abilities, or personality. Measurement of these unobservable phenomena is difficult and much of the research and accumulated art of this discipline is designed to reliably define and then quantify. [psychometrics | NCIT_14.10d]
NCI thesaurus code: C17034
date: November 18, 2014

public health surveillance
type: Class
subclass of: population surveillance
semantic type: Research Activity
editor: Tanja Bekhuis
definition: The ongoing, systematic collection, analysis, and interpretation of health-related data with the purpose of preventing or controlling disease or injury, or of identifying unusual events of public health importance, followed by the dissemination and use of information for public health action. [From Am J Prev Med 2011;41(6):636] [MeSH_2014]
legacy term: population surveillance
semantic type: Health Care Activity
me SH code: D062486

published erratum
type: Class
subclass of: Publication Type
variant: corrigenda
variant: errata
definition: Work consisting of an acknowledgment of an error, issued by a publisher, editor, or author. It customarily cites the source where the error occurred, giving complete bibliographic data for retrieval. In the case of books and monographs, author, title, imprint, paging, and other helpful references will be given; in the case of journal articles, the author, title, paging, and journal reference will be shown. An erratum notice is variously cited as Errata or Corrigenda. [MeSH_2014]
me SH code: D016425
editor: Ashleigh Faith
semantic type: Intellectual Product

qualitative evaluation
type: Class
subclass of: evaluation
variant: qualitative evaluations

qualitative study
type: Class
subclass of: Study Design
variant: qualitative design
editor: Ashleigh Faith
variant: qualitative designs
variant: qualitative studies
me SH code: D036301
definition: Research that derives data from observation, interviews, or verbal interactions and focuses on the meanings and interpretations of the participants (From Holloway and Wheeler, "Ethical issues in qualitative nursing research," Nursing Ethics, 1995 Sep; 2(3): 223-232). [MeSH_2014]
semantic type: Research Activity

quantitative evaluation
type: Class
subclass of: evaluation
variant: quantitative evaluations

quantitative study
type: Class
subclass of: Study Design
variant: numerical studies
variant: quantitative studies
variant: quantitative design
variant: numerical study
variant: quantitative designs

quasi-experimental clinical trial
type: Class
subclass of: quasi-experimental design
variant: quasi-experimental clinical trial

quasi-experimental design
type: Class
subclass of: controlled design
variant: quasi experimental design
variant: quasi experimental designs
variant: quasi experimental studies
variant: quasi experimental study
variant: quasi experimental trial
variant: quasi experimental trials
variant: quasi-experimental designs
variant: quasi-experimental studies
variant: quasi-experimental study
variant: quasi-experimental trial
variant: quasi-experimental trials
variant: quasiexperimental design
variant: quasiexperimental designs
variant: quasiexperimental studies
variant: quasiexperimental study
variant: quasiexperimental trial
variant: quasiexperimental trials

quasi randomized controlled design
type: Class
subclass of: quasi randomized design
variant: quasi randomised controlled design
variant: quasi randomised controlled designs
variant: quasi randomised controlled studies
variant: quasi randomised controlled study
variant: quasi randomised controlled trial
variant: quasi randomised controlled trials
variant: quasi randomized controlled designs
variant: quasi randomized controlled studies
variant: quasi randomized controlled study
variant: quasi randomized controlled trial
variant: quasi randomized controlled trials
variant: quasi rct
variant: quasi rcts
variant: quasi-randomised controlled design
variant: quasi-randomised controlled designs
variant: quasi-randomised controlled studies
variant: quasi-randomised controlled study
variant: quasi-randomised controlled trial
variant: quasi-randomised controlled trials
variant: quasi-randomized controlled design
variant: quasi-randomized controlled designs
variant: quasi-randomized controlled studies
variant: quasi-randomized controlled study
variant: quasi-randomized controlled trial
variant: quasi-randomized controlled trials

quasi randomized design
type: Class
subclass of: quasi-experimental design
variant: quasi randomised design
variant: quasi randomised designs
variant: quasi randomised studies
variant: quasi randomised study
variant: quasi randomised trial
variant: quasi randomised trials
variant: quasi randomized designs
variant: quasi randomized studies
variant: quasi randomized study
variant: quasi randomized trial
variant: quasi randomized trials
variant: quasi-randomised design
variant: quasi-randomised designs
variant: quasi-randomised studies
variant: quasi-randomised study
variant: quasi-randomised trial
variant: quasi-randomised trials
variant: quasi-randomized design
variant: quasi-randomized designs
variant: quasi-randomized studies
variant: quasi-randomized study
variant: quasi-randomized trial
variant: quasi-randomized trials

randomized clinical trial
type: Class
subclass of: clinical trial
subclass of: randomized design
variant: randomised clinical design
variant: randomised clinical designs
variant: randomised clinical studies
variant: randomised clinical study
variant: randomised clinical trial
variant: randomised clinical trials
variant: randomized clinical design
variant: randomized clinical designs
variant: randomized clinical studies
variant: randomized clinical study
variant: randomized clinical trials
UMLS CUI: C0206034
definition: A study in which the participants are assigned by chance to separate groups that compare different treatments; neither the researchers nor the participants can choose which group. Using chance to assign people to groups means that the groups will be similar and that the treatments they receive can be compared objectively. At the time of the trial, it is not known which treatment is best. It is the patient's choice to be in a randomized trial. [NCIT_14.05d]
editor: Ashleigh Faith
NCI thesaurus code: C15417
definition: Used for original reports of prospective clinical studies in which the (comparative) efficacy of one or more medical interventions in humans is evaluated; also used for prospective clinical veterinary trials in which the (comparative) efficacy of one or more medical interventions in animals is evaluated. [Clinical trial | Embase_2014]
definition: Used as a drug subheading when the clinical trial of a drug is reported. [Clinical trial | Embase_2014]
semantic type: Research Activity

randomized controlled clinical trial
type: Class
subclass of: controlled clinical trial
subclass of: randomized clinical trial
definition: A study in which the participants are assigned by chance to separate groups to evaluate treatments. The study also includes a control group, which is undergoing the same rigors of the study with placebo treatment or standard treatment. The trial can also be controlled by the addition of a test group to ensure there are no factors present to skew the results and by the inclusion of peer-review analysis by appropriate government officials. [NCIT_14.08d]
editor: Tanja Bekhuis
UMLS CUI: C0206035
semantic type: Research Activity
NCI thesaurus code: C46079

randomized controlled trial
type: Class
subclass of: controlled design
variant: controlled trial, randomized
variant: randomised controlled trial
variant: randomised controlled design
variant: randomised controlled designs
variant: randomised controlled studies
variant: randomised controlled study
variant: randomised controlled trials
variant: randomized controlled designs
variant: randomized controlled studies
variant: randomized controlled study
variant: randomized controlled trial
variant: randomized controlled trials
variant: rct
variant: rcts
variant: trial, randomized controlled
editor: Ashleigh Faith
variant: randomized control trial
semantic type: Research Activity
definition: Work consisting of a clinical trial that involves at least one test treatment and one control treatment, concurrent enrollment and follow-up of the test- and control-treated groups, and in which the treatments to be administered are selected by a random process, such as the use of a random-numbers table. [MeSH_2014]
variant: randomized controlled design
variant: randomised control trial
me SH code: D016449
semantic type: Intellectual Product

randomized cross-over design
type: Class
subclass of: cross-over design
subclass of: randomized design
variant: randomised cross-over design
variant: randomised cross-over designs
variant: randomised cross-over studies
variant: randomised cross-over study
variant: randomised cross-over trial
variant: randomised cross-over trials
variant: randomised crossover design
variant: randomised crossover designs
variant: randomised crossover studies
variant: randomised crossover study
variant: randomised crossover trial
variant: randomised crossover trials
variant: randomized cross-over designs
variant: randomized cross-over studies
variant: randomized cross-over study
variant: randomized cross-over trial
variant: randomized cross-over trials
variant: randomized crossover design
variant: randomized crossover designs
variant: randomized crossover studies
variant: randomized crossover study
variant: randomized crossover trial
variant: randomized crossover trials

randomized design
type: Class
subclass of: Study Design
variant: randomised design
variant: randomised designs
variant: randomised studies
variant: randomised study
variant: randomised trial
variant: randomised trials
variant: randomized designs
variant: randomized studies
variant: randomized study
variant: randomized trial
variant: randomized trials

rapid review
type: Class
subclass of: literature review
variant: rapid reviews

rapid review
type: Class
subclass of: literature review
variant: rapid reviews

registry study
type: Class
subclass of: Study Design
variant: register study
variant: register studies
variant: registry studies

reliability design
type: Class
subclass of: Study Design
variant: reliability designs
variant: reliability studies
variant: reliability study
variant: reliability trial
variant: reliability trials

research report
type: Class
subclass of: Publication Type
variant: research reports
semantic type: Intellectual Product
editor: Tanja Bekhuis
definition: Detailed account or statement or formal record of data resulting from empirical inquiry. [MeSH_2015]
date: November 13, 2014
me SH code: D058028

retracted publication
type: Class
subclass of: Publication Type
variant: retracted publications
editor: Ashleigh Faith
semantic type: Intellectual Product
me SH code: D016441
definition: Work consisting of the designation of an article or book as retracted in whole or in part by an author or authors or an authorized representative. It identifies a citation previously published and now retracted through a formal issuance from the author, publisher, or other authorized agent, and is distinguished from RETRACTION OF PUBLICATION, which identifies the citation retracting the original published item. [MeSH_2014]

retrospective case control design
type: Class
subclass of: retrospective study
variant: retrospective case control designs
variant: retrospective case control studies
variant: retrospective case control study
variant: retrospective case control trial
variant: retrospective case control trials
variant: retrospective case-control design
variant: retrospective case-control designs
variant: retrospective case-control studies
variant: retrospective case-control study
variant: retrospective case-control trial
variant: retrospective case-control trials

retrospective case series
type: Class
subclass of: case series

retrospective cohort study
type: Class
subclass of: cohort study
variant: historical cohort studies
variant: cohort study, historical
variant: retrospective cohort studies
variant: historic cohort study
variant: retrospective cohort trial
editor: Tanja Bekhuis
variant: historic cohort studies
semantic type: Research Activity
variant: study, historical cohort
variant: retrospective cohort trials
variant: historical cohort trials
definition: A research study in which the medical records of groups of individuals who are alike in many ways but differ by a certain characteristic (for example, female nurses who smoke and those who do not smoke) are compared for a particular outcome (such as lung cancer). [NCIT_14.08d]
UMLS CUI: C2985505
variant: historical cohort designs
variant: retrospective cohort designs
variant: studies, historical cohort
variant: cohort studies, historical
variant: retrospective cohort design
variant: historical cohort design
NCI thesaurus code: C93228
variant: historical cohort trial
variant: historical cohort study

retrospective study
type: Class
subclass of: Study Design
subclass of: Restriction
  on property: isCrossFunctionalWith
  some values from: prospective study
editor: Ashleigh Faith
me SH code: D012189
semantic type: Quantitative Concept
definition: Studies used to test etiologic hypotheses in which inferences about an exposure to putative causal factors are derived from data relating to characteristics of persons under study or to events or experiences in their past. The essential feature is that some of the persons under study have the disease or outcome of interest and their characteristics are compared with those of unaffected persons. [MeSH_2014]
variant: retrospective design
variant: retrospective designs
variant: retrospective studies
variant: retrospective trial
variant: retrospective trials
variant: study, retrospective
NCI thesaurus code: C53312
definition: a longitudinal epidemiologic study in which participating individuals are classified as either having (cases) or lacking (controls) some outcome and their histories are examined for the presence of specific factors possibly associated with that outcome. Cases and controls are often matched with respect to certain demographic or other variables but need not be. As compared with prospective studies, retrospective studies suffer from drawbacks: although they can measure the odds ratio, which often approximates relative risk, they cannot reveal true incidence rates or attributable risk. Also, large biases can be introduced both in the selection of controls and in the recall of past exposure to risk factors. The advantage of the retrospective study is its small scale, usually short time for completion, and its applicability to rare diseases, which would require study of very large cohorts in prospective studies. [Emtree_2014] [ Dorland's Medical Dictionary_2011]
definition: A study in which known outcomes are examined in hindsight using existing records. [NCIT_14.05d]
UMLS CUI: C0035363
semantic type: Research Activity
definition: A study that compares two groups of people: those with the disease or condition under study (cases) and a very similar group of people who do not have the disease or condition (controls). Researchers study the medical and lifestyle histories of the people in each group to learn what factors may be associated with the disease or condition. For example, one group may have been exposed to a particular substance that the other was not. [NCIT_14.05d]

Axiom
comment: [Embase_2014]
annotated source: retrospective study
annotated property: subClassOf
annotated target: Restriction
  on property: isCrossFunctionalWith
  some values from: prospective study

retrospective panel study
type: Class
subclass of: retrospective study
variant: retrospective panel studies

literature review
type: Class
subclass of: Study Design
variant: review
variant: review of reported cases
variant: review, multicase
variant: reviews
me SH code: D016454
variant: review literature
variant: literature reviews
variant: review, academic
variant: review of literature
editor: Ashleigh Faith
semantic type: Intellectual Product
definition: Significant review of original research. [Emtree_2014]
definition: An article or book published after examination of published material on a subject. It may be comprehensive to various degrees and the time range of material scrutinized may be broad or narrow, but the reviews most often desired are reviews of the current literature. The textual material examined may be equally broad and can encompass, in medicine specifically, clinical material as well as experimental research or case reports. State-of-the-art reviews tend to address more current matters. [MeSH_2014]

records review
type: Class
subclass of: Study Design
variant: review of records
variant: record review

scientific publication
type: Class
subclass of: Publication Type
NCI thesaurus code: C19026
date: November 13, 2014
definition: A class of publication in which original scientific work is described. The format usually includes an introduction in which relevant concepts are identified and the experimental system under study is presented, a section describing the experiments that were performed to test a specific hypothesis and the results and observations that were obtained, a section in which the results are discussed relative to findings by other investigators and the current state of knowledge in the field, and a section describing the experimental methods and procedures in sufficient detail to enable the reproduction of the work by independent investigators. [NCIT_14.10d]
variant: scientific publications
semantic type: Intellectual Product
editor: Tanja Bekhuis
UMLS CUI: C1704324

scoping review
type: Class
subclass of: literature review
variant: scoping reviews

scoping review
type: Class
subclass of: literature review
variant: scoping reviews

semi-structured interview
type: Class
subclass of: interview
variant: semistructured interview
variant: semistructured interviews
variant: semi-structured interviews

sentinel surveillance
type: Class
subclass of: population surveillance
semantic type: Occupational Activity
legacy term: population surveillance
definition: Monitoring of rate of occurrence of specific conditions to assess the stability or change in health levels of a population. It is also the study of disease rates in a specific cohort such as in a geographic area or population subgroup to estimate trends in larger population. [From Last, Dictionary of Epidemiology, 2d ed] [MeSH_2014]
me SH code: D018571
editor: Tanja Bekhuis

single blind randomized controlled trial
type: Class
subclass of: randomized controlled trial
variant: single blinded randomised controlled design
variant: single blinded randomised controlled designs
variant: single blinded randomised controlled studies
variant: single blinded randomised controlled study
variant: single blinded randomised controlled trial
variant: single blinded randomised controlled trials
variant: single blinded randomized controlled design
variant: single blinded randomized controlled designs
variant: single blinded randomized controlled studies
variant: single blinded randomized controlled study
variant: single blinded randomized controlled trial
variant: single blinded randomized controlled trials
variant: single blinded rct
variant: single blinded rcts
variant: single-blinded randomised controlled design
variant: single-blinded randomised controlled designs
variant: single-blinded randomised controlled studies
variant: single-blinded randomised controlled study
variant: single-blinded randomised controlled trial
variant: single-blinded randomised controlled trials
variant: single-blinded randomized controlled design
variant: single-blinded randomized controlled designs
variant: single-blinded randomized controlled studies
variant: single-blinded randomized controlled study
variant: single-blinded randomized controlled trial
variant: single-blinded randomized controlled trials
variant: single-blinded rct
variant: single-blinded rcts

single case study
type: Class
subclass of: case study
variant: n-of-1 design
variant: n-of-1 designs
variant: n-of-1 studies
variant: n-of-1 study
variant: n-of-1 trial
variant: n-of-1 trials
variant: n-of-one design
variant: n-of-one designs
variant: n-of-one studies
variant: n-of-one study
variant: n-of-one trial
variant: n-of-one trials
variant: single subject studies
variant: single-case designs
variant: single-case design
variant: single-subject trial
variant: single-case study
variant: single subject trials
variant: single-subject studies
variant: single-subject trials
variant: single case trials
variant: single-case trial
variant: single case trial
variant: single case designs
variant: single-case trials
variant: single case studies
variant: single-subject study
variant: single-subject designs
variant: single subject design
variant: single-case studies
variant: single-subject design
variant: single case design
variant: single case reports
variant: single subject study
variant: single case report
variant: single subject designs
variant: single subject trial

solomon four group design
type: Class
subclass of: pre-and-post design
variant: solomon four group designs
variant: solomon four group studies
variant: solomon four group study
variant: solomon four group trial
variant: solomon four group trials
variant: solomon four-group design
variant: solomon four-group designs
variant: solomon four-group studies
variant: solomon four-group study
variant: solomon four-group trial
variant: solomon four-group trials

stepped wedge design
type: Class
subclass of: Study Design
variant: stepped wedge designs
variant: stepped wedge studies
variant: stepped wedge study
variant: stepped wedge trial
variant: stepped wedge trials

structured interview
type: Class
subclass of: interview
variant: structured interviews

surveillance
type: Class
subclass of: health survey
editor: Tanja Bekhuis
definition: In medicine, the ongoing collection of information about a disease, such as cancer, in a certain group of people. The information collected may include where the disease occurs in a population and whether it affects people of a certain gender, age, or ethnic group. [NCIT_14.08d]
semantic type: Health Care Activity
NCI thesaurus code: C15719
definition: The systematic collection, analysis, and interpretation of health data on an ongoing basis. [NCIT_14.08d]

survey
type: Class
subclass of: Study Design
variant: surveys
definition: An examination or inspection carried out with specific aims in mind, a search for particular kinds of information. This sense is carried in a number of specific kinds of research designs in which questionnaires, inventories or interviews may be employed to gather information about attitudes, opinions or preferences in a society or some segment of it. [The Penguin Dictionary of Psychology, 2009]
editor: Tanja Bekhuis

systematic review
type: Class
subclass of: literature review
variant: review, systematic
variant: systematic reviews
editor: Ashleigh Faith
definition: Used for studies that systematically summarize all relevant evidence pertaining to a defined health question, and including items identified as such by the author. [Emtree_2014]

systematic review
type: Class
subclass of: literature review
variant: review, systematic
variant: systematic reviews
editor: Ashleigh Faith
definition: Used for studies that systematically summarize all relevant evidence pertaining to a defined health question, and including items identified as such by the author. [Emtree_2014]

technical report
type: Class
subclass of: Publication Type
editor: Tanja Bekhuis
definition: Work consisting of a formal report giving details of the investigation and results of a medical or other scientific problem. When issued by a government agency or comparable official body, its contents may be classified, unclassified, or declassified with regard to security clearance. This publication type may also cover a scientific paper or article that records the current state or current position of scientific research and development. If so labeled by the editor or publisher, this publication type may be properly used for journal articles. [MeSH_2015]
variant: technical reports
date: November 13, 2014
me SH code: D016427
semantic type: Intellectual Product

theoretical design
type: Class
subclass of: Study Design
variant: theoretical designs
variant: theoretical studies
variant: theoretical study

time and motion study
type: Class
subclass of: Study Design
variant: time and motion studies
variant: work sampling
editor: Ashleigh Faith
me SH code: D013996
variant: work simplification
variant: performance, task
variant: task performance
legacy term: Task performance and analysis [1973-74]
semantic type: Intellectual Product
variant: task performance and analysis
definition: The observation and analysis of movements in a task with an emphasis on the amount of time required to perform the task. [MeSH_2014]

time series design
type: Class
subclass of: Study Design
subclass of: Restriction
  on property: isCrossFunctionalWith
  some values from: longitudinal design
variant: multiple time series
variant: time design
variant: time designs
variant: time series
variant: time series analysis
variant: time studies
variant: time study
variant: time trial
variant: time trials
variant: time series designs
variant: time series studies
variant: time series study

Axiom
comment: [Embase_2014] [Dorland's Medical Dictionary_2011]
annotated source: time series design
annotated property: subClassOf
annotated target: Restriction
  on property: isCrossFunctionalWith
  some values from: longitudinal design

trend design
type: Class
subclass of: Study Design
variant: trend designs
variant: trend studies
variant: trend study
variant: trend trial
variant: trend trials

umbrella review
type: Class
subclass of: literature review
variant: umbrella reviews

umbrella review
type: Class
subclass of: literature review
variant: umbrella reviews

uncontrolled longitudinal design
type: Class
subclass of: longitudinal design
variant: uncontrolled longitudinal designs
variant: uncontrolled longitudinal studies
variant: uncontrolled longitudinal study
variant: uncontrolled longitudinal trial
variant: uncontrolled longitudinal trials

validity design
type: Class
subclass of: Study Design
variant: validation studies
variant: validation study
variant: validity designs
variant: validity studies
variant: validity study
variant: validity trial
variant: validity trials
editor: Ashleigh Faith
me SH code: D023361
semantic type: Intellectual Product

white paper
type: Class
subclass of: government publication
variant: white papers

phase I/II trial
type: Class
subclass of: clinical trial
editor: Tanja Bekhuis
variant: trial phase1/2
UMLS CUI: C1519043
definition: A clinical research protocol designed to study the safety, dosage levels and response to new treatment. Phase I/II trials combine a Phase I and a Phase II trial of the same treatment into a single protocol. [NCIT_14.08d]
semantic type: Research Activity
NCI thesaurus code: C15693
variant: trial phase 1-2
definition: A class of clinical study that combines elements characteristic of traditional Phase I and Phase II trials. See also Phase I, Phase II. [NCIT_14.08d] [Contributing_Source_CDISC]
definition: A trial to study the safety, dosage levels, and response to a new treatment. [NCIT_14.08d]

phase II/III trial
type: Class
subclass of: clinical trial
variant: trial phase 2/3
definition: A class of clinical study that combines elements characteristic of traditional Phase II and Phase III trials. [NCIT_14.08d] [Contributing_Source_CDISC]
semantic type: Research Activity
definition: A type of clinical study that combines elements characteristic of traditional Phase II and Phase III trials. [NCIT_14.08d]
NCI thesaurus code: C15694
editor: Tanja Bekhuis
variant: trial phase 2-3
definition: A trial to study response to a new treatment and the effectiveness of the treatment compared with the standard treatment regimen. [NCIT_14.08d]
UMLS CUI: C1519042

Antibody
type: Class
subclass of: Protein
disjoint with: Authoriative Organization
disjoint with: CYP1A2
disjoint with: CYP2C19
disjoint with: CYP2C9
disjoint with: CYP2D6
disjoint with: CYP2E1
disjoint with: CYP3A4
disjoint with: CYP3A5
disjoint with: Clinical Trial Participants
disjoint with: Cytochrome P450
disjoint with: Drug Drug Interaction
disjoint with: Drug Interaction
disjoint with: Drug Label
disjoint with: Drug Manufacturer
disjoint with: EV CT DDI
disjoint with: EV CT DDI Data
disjoint with: EV CT DDI Material
disjoint with: EV CT PK DDI
disjoint with: EV CT PK DDI Data
disjoint with: EV CT PK DDI Material
disjoint with: EV CT PK Genotype
disjoint with: EV CT PK Genotype Data
disjoint with: EV CT PK Genotype Material
disjoint with: EV CT PK Phenotype
disjoint with: EV CT PK Phenotype Data
disjoint with: EV CT PK Phenotype Material
disjoint with: EV CT Pharmacokinetic
disjoint with: EV CT Pharmacokinetic Data
disjoint with: EV CT Pharmacokinetic Material
disjoint with: EV Case Report
disjoint with: EV Case Report ADE
disjoint with: EV Case Report ADE Data
disjoint with: EV Case Report ADE Material
disjoint with: EV Case Report ADE Public Reported
disjoint with: EV Case Report ADE Public Reported Data
disjoint with: EV Case Report ADE Public Reported Material
disjoint with: EV Case Report DI CR
disjoint with: EV Case Report DI CR Data
disjoint with: EV Case Report DI CR Evaluated
disjoint with: EV Case Report DI CR Evaluated Data
disjoint with: EV Case Report DI CR Evaluated Material
disjoint with: EV Case Report DI CR Material
disjoint with: EV Case Report Data
disjoint with: EV Case Report Material
disjoint with: EV Clinical Trial
disjoint with: EV Clinical Trial Data
disjoint with: EV Clinical Trial Material
disjoint with: EV DrugClinicalReview
disjoint with: EV Drug Review
disjoint with: EV EX Met Enz ID
disjoint with: EV EX Met Enz ID CYP450
disjoint with: EV EX Met Enz ID CYP450 Data
disjoint with: EV EX Met Enz ID CYP450 Hum Liver Microsome
disjoint with: EV EX Met Enz ID CYP450 Hum Liver Microsome Antibody
disjoint with: EV EX Met Enz ID CYP450 Hum Liver Microsome Antibody Data
disjoint with: EV EX Met Enz ID CYP450 Hum Liver Microsome Antibody Material
disjoint with: EV EX Met Enz ID CYP450 Hum Liver Microsome Chem
disjoint with: EV EX Met Enz ID CYP450 Hum Liver Microsome Chem Data
disjoint with: EV EX Met Enz ID CYP450 Hum Liver Microsome Chem Material
disjoint with: EV EX Met Enz ID CYP450 Hum Liver Microsome Data
disjoint with: EV EX Met Enz ID CYP450 Hum Liver Microsome Material
disjoint with: EV EX Met Enz ID CYP450 Hum Recom
disjoint with: EV EX Met Enz ID CYP450 Hum Recom Antibody
disjoint with: EV EX Met Enz ID CYP450 Hum Recom Antibody Data
disjoint with: EV EX Met Enz ID CYP450 Hum Recom Antibody Material
disjoint with: EV EX Met Enz ID CYP450 Hum Recom Chem
disjoint with: EV EX Met Enz ID CYP450 Hum Recom Chem Data
disjoint with: EV EX Met Enz ID CYP450 Hum Recom Chem Material
disjoint with: EV EX Met Enz ID CYP450 Hum Recom Data
disjoint with: EV EX Met Enz ID CYP450 Hum Recom Material
disjoint with: EV EX Met Enz ID CYP450 Material
disjoint with: EV EX Met Enz ID Data
disjoint with: EV EX Met Enz ID Material
disjoint with: EV EX Met Enz Inhibit
disjoint with: EV EX Met Enz Inhibit CYP450
disjoint with: EV EX Met Enz Inhibit CYP450 Data
disjoint with: EV EX Met Enz Inhibit CYP450 Human Liver Microsome
disjoint with: EV EX Met Enz Inhibit CYP450 Human Liver Microsome Data

Authoriative Organization
type: Class
disjoint with: CYP1A2
disjoint with: CYP2C19
disjoint with: CYP2C9
disjoint with: CYP2D6
disjoint with: CYP2E1
disjoint with: CYP3A4
disjoint with: CYP3A5
disjoint with: Cellular Metabolism
disjoint with: Chemical Inhibitor
disjoint with: Clinical Trial Participants
disjoint with: Cytochrome P450
disjoint with: Decreased Drug AUC
disjoint with: Decreased Drug Level
disjoint with: Drug
disjoint with: Drug Absorption
disjoint with: Drug Distribution
disjoint with: Drug Drug Interaction
disjoint with: Drug Excretion
disjoint with: Drug Interaction
disjoint with: Drug Label
disjoint with: Drug Manufacturer
disjoint with: Drug Metabolism
disjoint with: EV CT DDI
disjoint with: EV CT DDI Data
disjoint with: EV CT DDI Material
disjoint with: EV CT PK DDI
disjoint with: EV CT PK DDI Data
disjoint with: EV CT PK DDI Material
disjoint with: EV CT PK Genotype
disjoint with: EV CT PK Genotype Data
disjoint with: EV CT PK Genotype Material
disjoint with: EV CT PK Phenotype
disjoint with: EV CT PK Phenotype Data
disjoint with: EV CT PK Phenotype Material
disjoint with: EV CT Pharmacokinetic
disjoint with: EV CT Pharmacokinetic Data
disjoint with: EV CT Pharmacokinetic Material
disjoint with: EV Case Report
disjoint with: EV Case Report ADE
disjoint with: EV Case Report ADE Data
disjoint with: EV Case Report ADE Material
disjoint with: EV Case Report ADE Public Reported
disjoint with: EV Case Report ADE Public Reported Data
disjoint with: EV Case Report ADE Public Reported Material
disjoint with: EV Case Report DI CR
disjoint with: EV Case Report DI CR Data
disjoint with: EV Case Report DI CR Evaluated
disjoint with: EV Case Report DI CR Evaluated Data
disjoint with: EV Case Report DI CR Evaluated Material
disjoint with: EV Case Report DI CR Material
disjoint with: EV Case Report Data
disjoint with: EV Case Report Material
disjoint with: EV Clinical Trial
disjoint with: EV Clinical Trial Data
disjoint with: EV Clinical Trial Material
disjoint with: EV DrugClinicalReview
disjoint with: EV Drug Review
disjoint with: EV EX Met Enz ID
disjoint with: EV EX Met Enz ID CYP450
disjoint with: EV EX Met Enz ID CYP450 Data
disjoint with: EV EX Met Enz ID CYP450 Hum Liver Microsome
disjoint with: EV EX Met Enz ID CYP450 Hum Liver Microsome Antibody
disjoint with: EV EX Met Enz ID CYP450 Hum Liver Microsome Antibody Data
disjoint with: EV EX Met Enz ID CYP450 Hum Liver Microsome Antibody Material
disjoint with: EV EX Met Enz ID CYP450 Hum Liver Microsome Chem
disjoint with: EV EX Met Enz ID CYP450 Hum Liver Microsome Chem Data
disjoint with: EV EX Met Enz ID CYP450 Hum Liver Microsome Chem Material
disjoint with: EV EX Met Enz ID CYP450 Hum Liver Microsome Data
disjoint with: EV EX Met Enz ID CYP450 Hum Liver Microsome Material
disjoint with: EV EX Met Enz ID CYP450 Hum Recom
disjoint with: EV EX Met Enz ID CYP450 Hum Recom Antibody
disjoint with: EV EX Met Enz ID CYP450 Hum Recom Antibody Data
disjoint with: EV EX Met Enz ID CYP450 Hum Recom Antibody Material
disjoint with: EV EX Met Enz ID CYP450 Hum Recom Chem
disjoint with: EV EX Met Enz ID CYP450 Hum Recom Chem Data
disjoint with: EV EX Met Enz ID CYP450 Hum Recom Chem Material
disjoint with: EV EX Met Enz ID CYP450 Hum Recom Data
disjoint with: EV EX Met Enz ID CYP450 Hum Recom Material
disjoint with: EV EX Met Enz ID CYP450 Material

CYP1A2
type: Class
subclass of: Cytochrome P450
disjoint with: CYP2C19
disjoint with: CYP2C9
disjoint with: CYP2D6
disjoint with: CYP2E1
disjoint with: CYP3A4
disjoint with: CYP3A5
disjoint with: Clinical Trial Participants
disjoint with: Drug Drug Interaction
disjoint with: Drug Interaction
disjoint with: Drug Label
disjoint with: Drug Manufacturer
disjoint with: EV CT DDI
disjoint with: EV CT DDI Data
disjoint with: EV CT DDI Material
disjoint with: EV CT PK DDI
disjoint with: EV CT PK DDI Data
disjoint with: EV CT PK DDI Material
disjoint with: EV CT PK Genotype
disjoint with: EV CT PK Genotype Data
disjoint with: EV CT PK Genotype Material
disjoint with: EV CT PK Phenotype
disjoint with: EV CT PK Phenotype Data
disjoint with: EV CT PK Phenotype Material
disjoint with: EV CT Pharmacokinetic
disjoint with: EV CT Pharmacokinetic Data
disjoint with: EV CT Pharmacokinetic Material
disjoint with: EV Case Report
disjoint with: EV Case Report ADE
disjoint with: EV Case Report ADE Data
disjoint with: EV Case Report ADE Material
disjoint with: EV Case Report ADE Public Reported
disjoint with: EV Case Report ADE Public Reported Data
disjoint with: EV Case Report ADE Public Reported Material
disjoint with: EV Case Report DI CR
disjoint with: EV Case Report DI CR Data
disjoint with: EV Case Report DI CR Evaluated
disjoint with: EV Case Report DI CR Evaluated Data
disjoint with: EV Case Report DI CR Evaluated Material
disjoint with: EV Case Report DI CR Material
disjoint with: EV Case Report Data
disjoint with: EV Case Report Material
disjoint with: EV Clinical Trial
disjoint with: EV Clinical Trial Data
disjoint with: EV Clinical Trial Material
disjoint with: EV DrugClinicalReview
disjoint with: EV Drug Review
disjoint with: EV EX Met Enz ID
disjoint with: EV EX Met Enz ID CYP450
disjoint with: EV EX Met Enz ID CYP450 Data
disjoint with: EV EX Met Enz ID CYP450 Hum Liver Microsome
disjoint with: EV EX Met Enz ID CYP450 Hum Liver Microsome Antibody
disjoint with: EV EX Met Enz ID CYP450 Hum Liver Microsome Antibody Data
disjoint with: EV EX Met Enz ID CYP450 Hum Liver Microsome Antibody Material
disjoint with: EV EX Met Enz ID CYP450 Hum Liver Microsome Chem
disjoint with: EV EX Met Enz ID CYP450 Hum Liver Microsome Chem Data
disjoint with: EV EX Met Enz ID CYP450 Hum Liver Microsome Chem Material
disjoint with: EV EX Met Enz ID CYP450 Hum Liver Microsome Data
disjoint with: EV EX Met Enz ID CYP450 Hum Liver Microsome Material
disjoint with: EV EX Met Enz ID CYP450 Hum Recom
disjoint with: EV EX Met Enz ID CYP450 Hum Recom Antibody
disjoint with: EV EX Met Enz ID CYP450 Hum Recom Antibody Data
disjoint with: EV EX Met Enz ID CYP450 Hum Recom Antibody Material
disjoint with: EV EX Met Enz ID CYP450 Hum Recom Chem
disjoint with: EV EX Met Enz ID CYP450 Hum Recom Chem Data
disjoint with: EV EX Met Enz ID CYP450 Hum Recom Chem Material
disjoint with: EV EX Met Enz ID CYP450 Hum Recom Data
disjoint with: EV EX Met Enz ID CYP450 Hum Recom Material
disjoint with: EV EX Met Enz ID CYP450 Material
disjoint with: EV EX Met Enz ID Data
disjoint with: EV EX Met Enz ID Material
disjoint with: EV EX Met Enz Inhibit
disjoint with: EV EX Met Enz Inhibit CYP450
disjoint with: EV EX Met Enz Inhibit CYP450 Data
disjoint with: EV EX Met Enz Inhibit CYP450 Human Liver Microsome
disjoint with: EV EX Met Enz Inhibit CYP450 Human Liver Microsome Data
disjoint with: EV EX Met Enz Inhibit CYP450 Human Liver Microsome Material
disjoint with: EV EX Met Enz Inhibit CYP450 Human Recom
disjoint with: EV EX Met Enz Inhibit CYP450 Human Recom Data

CYP2C19
type: Class
subclass of: Cytochrome P450
disjoint with: CYP2C9
disjoint with: CYP2D6
disjoint with: CYP2E1
disjoint with: CYP3A4
disjoint with: CYP3A5
disjoint with: Clinical Trial Participants
disjoint with: Drug Drug Interaction
disjoint with: Drug Interaction
disjoint with: Drug Label
disjoint with: Drug Manufacturer
disjoint with: EV CT DDI
disjoint with: EV CT DDI Data
disjoint with: EV CT DDI Material
disjoint with: EV CT PK DDI
disjoint with: EV CT PK DDI Data
disjoint with: EV CT PK DDI Material
disjoint with: EV CT PK Genotype
disjoint with: EV CT PK Genotype Data
disjoint with: EV CT PK Genotype Material
disjoint with: EV CT PK Phenotype
disjoint with: EV CT PK Phenotype Data
disjoint with: EV CT PK Phenotype Material
disjoint with: EV CT Pharmacokinetic
disjoint with: EV CT Pharmacokinetic Data
disjoint with: EV CT Pharmacokinetic Material
disjoint with: EV Case Report
disjoint with: EV Case Report ADE
disjoint with: EV Case Report ADE Data
disjoint with: EV Case Report ADE Material
disjoint with: EV Case Report ADE Public Reported
disjoint with: EV Case Report ADE Public Reported Data
disjoint with: EV Case Report ADE Public Reported Material
disjoint with: EV Case Report DI CR
disjoint with: EV Case Report DI CR Data
disjoint with: EV Case Report DI CR Evaluated
disjoint with: EV Case Report DI CR Evaluated Data
disjoint with: EV Case Report DI CR Evaluated Material
disjoint with: EV Case Report DI CR Material
disjoint with: EV Case Report Data
disjoint with: EV Case Report Material
disjoint with: EV Clinical Trial
disjoint with: EV Clinical Trial Data
disjoint with: EV Clinical Trial Material
disjoint with: EV DrugClinicalReview
disjoint with: EV Drug Review
disjoint with: EV EX Met Enz ID
disjoint with: EV EX Met Enz ID CYP450
disjoint with: EV EX Met Enz ID CYP450 Data
disjoint with: EV EX Met Enz ID CYP450 Hum Liver Microsome
disjoint with: EV EX Met Enz ID CYP450 Hum Liver Microsome Antibody
disjoint with: EV EX Met Enz ID CYP450 Hum Liver Microsome Antibody Data
disjoint with: EV EX Met Enz ID CYP450 Hum Liver Microsome Antibody Material
disjoint with: EV EX Met Enz ID CYP450 Hum Liver Microsome Chem
disjoint with: EV EX Met Enz ID CYP450 Hum Liver Microsome Chem Data
disjoint with: EV EX Met Enz ID CYP450 Hum Liver Microsome Chem Material
disjoint with: EV EX Met Enz ID CYP450 Hum Liver Microsome Data
disjoint with: EV EX Met Enz ID CYP450 Hum Liver Microsome Material
disjoint with: EV EX Met Enz ID CYP450 Hum Recom
disjoint with: EV EX Met Enz ID CYP450 Hum Recom Antibody
disjoint with: EV EX Met Enz ID CYP450 Hum Recom Antibody Data
disjoint with: EV EX Met Enz ID CYP450 Hum Recom Antibody Material
disjoint with: EV EX Met Enz ID CYP450 Hum Recom Chem
disjoint with: EV EX Met Enz ID CYP450 Hum Recom Chem Data
disjoint with: EV EX Met Enz ID CYP450 Hum Recom Chem Material
disjoint with: EV EX Met Enz ID CYP450 Hum Recom Data
disjoint with: EV EX Met Enz ID CYP450 Hum Recom Material
disjoint with: EV EX Met Enz ID CYP450 Material
disjoint with: EV EX Met Enz ID Data
disjoint with: EV EX Met Enz ID Material
disjoint with: EV EX Met Enz Inhibit
disjoint with: EV EX Met Enz Inhibit CYP450
disjoint with: EV EX Met Enz Inhibit CYP450 Data
disjoint with: EV EX Met Enz Inhibit CYP450 Human Liver Microsome
disjoint with: EV EX Met Enz Inhibit CYP450 Human Liver Microsome Data
disjoint with: EV EX Met Enz Inhibit CYP450 Human Liver Microsome Material
disjoint with: EV EX Met Enz Inhibit CYP450 Human Recom
disjoint with: EV EX Met Enz Inhibit CYP450 Human Recom Data
disjoint with: EV EX Met Enz Inhibit CYP450 Human Recom Material

CYP2C9
type: Class
subclass of: Cytochrome P450
disjoint with: CYP2D6
disjoint with: CYP2E1
disjoint with: CYP3A4
disjoint with: CYP3A5
disjoint with: Clinical Trial Participants
disjoint with: Drug Drug Interaction
disjoint with: Drug Interaction
disjoint with: Drug Label
disjoint with: Drug Manufacturer
disjoint with: EV CT DDI
disjoint with: EV CT DDI Data
disjoint with: EV CT DDI Material
disjoint with: EV CT PK DDI
disjoint with: EV CT PK DDI Data
disjoint with: EV CT PK DDI Material
disjoint with: EV CT PK Genotype
disjoint with: EV CT PK Genotype Data
disjoint with: EV CT PK Genotype Material
disjoint with: EV CT PK Phenotype
disjoint with: EV CT PK Phenotype Data
disjoint with: EV CT PK Phenotype Material
disjoint with: EV CT Pharmacokinetic
disjoint with: EV CT Pharmacokinetic Data
disjoint with: EV CT Pharmacokinetic Material
disjoint with: EV Case Report
disjoint with: EV Case Report ADE
disjoint with: EV Case Report ADE Data
disjoint with: EV Case Report ADE Material
disjoint with: EV Case Report ADE Public Reported
disjoint with: EV Case Report ADE Public Reported Data
disjoint with: EV Case Report ADE Public Reported Material
disjoint with: EV Case Report DI CR
disjoint with: EV Case Report DI CR Data
disjoint with: EV Case Report DI CR Evaluated
disjoint with: EV Case Report DI CR Evaluated Data
disjoint with: EV Case Report DI CR Evaluated Material
disjoint with: EV Case Report DI CR Material
disjoint with: EV Case Report Data
disjoint with: EV Case Report Material
disjoint with: EV Clinical Trial
disjoint with: EV Clinical Trial Data
disjoint with: EV Clinical Trial Material
disjoint with: EV DrugClinicalReview
disjoint with: EV Drug Review
disjoint with: EV EX Met Enz ID
disjoint with: EV EX Met Enz ID CYP450
disjoint with: EV EX Met Enz ID CYP450 Data
disjoint with: EV EX Met Enz ID CYP450 Hum Liver Microsome
disjoint with: EV EX Met Enz ID CYP450 Hum Liver Microsome Antibody
disjoint with: EV EX Met Enz ID CYP450 Hum Liver Microsome Antibody Data
disjoint with: EV EX Met Enz ID CYP450 Hum Liver Microsome Antibody Material
disjoint with: EV EX Met Enz ID CYP450 Hum Liver Microsome Chem
disjoint with: EV EX Met Enz ID CYP450 Hum Liver Microsome Chem Data
disjoint with: EV EX Met Enz ID CYP450 Hum Liver Microsome Chem Material
disjoint with: EV EX Met Enz ID CYP450 Hum Liver Microsome Data
disjoint with: EV EX Met Enz ID CYP450 Hum Liver Microsome Material
disjoint with: EV EX Met Enz ID CYP450 Hum Recom
disjoint with: EV EX Met Enz ID CYP450 Hum Recom Antibody
disjoint with: EV EX Met Enz ID CYP450 Hum Recom Antibody Data
disjoint with: EV EX Met Enz ID CYP450 Hum Recom Antibody Material
disjoint with: EV EX Met Enz ID CYP450 Hum Recom Chem
disjoint with: EV EX Met Enz ID CYP450 Hum Recom Chem Data
disjoint with: EV EX Met Enz ID CYP450 Hum Recom Chem Material
disjoint with: EV EX Met Enz ID CYP450 Hum Recom Data
disjoint with: EV EX Met Enz ID CYP450 Hum Recom Material
disjoint with: EV EX Met Enz ID CYP450 Material
disjoint with: EV EX Met Enz ID Data
disjoint with: EV EX Met Enz ID Material
disjoint with: EV EX Met Enz Inhibit
disjoint with: EV EX Met Enz Inhibit CYP450
disjoint with: EV EX Met Enz Inhibit CYP450 Data
disjoint with: EV EX Met Enz Inhibit CYP450 Human Liver Microsome
disjoint with: EV EX Met Enz Inhibit CYP450 Human Liver Microsome Data
disjoint with: EV EX Met Enz Inhibit CYP450 Human Liver Microsome Material
disjoint with: EV EX Met Enz Inhibit CYP450 Human Recom
disjoint with: EV EX Met Enz Inhibit CYP450 Human Recom Data
disjoint with: EV EX Met Enz Inhibit CYP450 Human Recom Material
disjoint with: EV EX Met Enz Inhibit CYP450 Material

CYP2D6
type: Class
subclass of: Cytochrome P450
disjoint with: CYP2E1
disjoint with: CYP3A4
disjoint with: CYP3A5
disjoint with: Clinical Trial Participants
disjoint with: Drug Drug Interaction
disjoint with: Drug Interaction
disjoint with: Drug Label
disjoint with: Drug Manufacturer
disjoint with: EV CT DDI
disjoint with: EV CT DDI Data
disjoint with: EV CT DDI Material
disjoint with: EV CT PK DDI
disjoint with: EV CT PK DDI Data
disjoint with: EV CT PK DDI Material
disjoint with: EV CT PK Genotype
disjoint with: EV CT PK Genotype Data
disjoint with: EV CT PK Genotype Material
disjoint with: EV CT PK Phenotype
disjoint with: EV CT PK Phenotype Data
disjoint with: EV CT PK Phenotype Material
disjoint with: EV CT Pharmacokinetic
disjoint with: EV CT Pharmacokinetic Data
disjoint with: EV CT Pharmacokinetic Material
disjoint with: EV Case Report
disjoint with: EV Case Report ADE
disjoint with: EV Case Report ADE Data
disjoint with: EV Case Report ADE Material
disjoint with: EV Case Report ADE Public Reported
disjoint with: EV Case Report ADE Public Reported Data
disjoint with: EV Case Report ADE Public Reported Material
disjoint with: EV Case Report DI CR
disjoint with: EV Case Report DI CR Data
disjoint with: EV Case Report DI CR Evaluated
disjoint with: EV Case Report DI CR Evaluated Data
disjoint with: EV Case Report DI CR Evaluated Material
disjoint with: EV Case Report DI CR Material
disjoint with: EV Case Report Data
disjoint with: EV Case Report Material
disjoint with: EV Clinical Trial
disjoint with: EV Clinical Trial Data
disjoint with: EV Clinical Trial Material
disjoint with: EV DrugClinicalReview
disjoint with: EV Drug Review
disjoint with: EV EX Met Enz ID
disjoint with: EV EX Met Enz ID CYP450
disjoint with: EV EX Met Enz ID CYP450 Data
disjoint with: EV EX Met Enz ID CYP450 Hum Liver Microsome
disjoint with: EV EX Met Enz ID CYP450 Hum Liver Microsome Antibody
disjoint with: EV EX Met Enz ID CYP450 Hum Liver Microsome Antibody Data
disjoint with: EV EX Met Enz ID CYP450 Hum Liver Microsome Antibody Material
disjoint with: EV EX Met Enz ID CYP450 Hum Liver Microsome Chem
disjoint with: EV EX Met Enz ID CYP450 Hum Liver Microsome Chem Data
disjoint with: EV EX Met Enz ID CYP450 Hum Liver Microsome Chem Material
disjoint with: EV EX Met Enz ID CYP450 Hum Liver Microsome Data
disjoint with: EV EX Met Enz ID CYP450 Hum Liver Microsome Material
disjoint with: EV EX Met Enz ID CYP450 Hum Recom
disjoint with: EV EX Met Enz ID CYP450 Hum Recom Antibody
disjoint with: EV EX Met Enz ID CYP450 Hum Recom Antibody Data
disjoint with: EV EX Met Enz ID CYP450 Hum Recom Antibody Material
disjoint with: EV EX Met Enz ID CYP450 Hum Recom Chem
disjoint with: EV EX Met Enz ID CYP450 Hum Recom Chem Data
disjoint with: EV EX Met Enz ID CYP450 Hum Recom Chem Material
disjoint with: EV EX Met Enz ID CYP450 Hum Recom Data
disjoint with: EV EX Met Enz ID CYP450 Hum Recom Material
disjoint with: EV EX Met Enz ID CYP450 Material
disjoint with: EV EX Met Enz ID Data
disjoint with: EV EX Met Enz ID Material
disjoint with: EV EX Met Enz Inhibit
disjoint with: EV EX Met Enz Inhibit CYP450
disjoint with: EV EX Met Enz Inhibit CYP450 Data
disjoint with: EV EX Met Enz Inhibit CYP450 Human Liver Microsome
disjoint with: EV EX Met Enz Inhibit CYP450 Human Liver Microsome Data
disjoint with: EV EX Met Enz Inhibit CYP450 Human Liver Microsome Material
disjoint with: EV EX Met Enz Inhibit CYP450 Human Recom
disjoint with: EV EX Met Enz Inhibit CYP450 Human Recom Data
disjoint with: EV EX Met Enz Inhibit CYP450 Human Recom Material
disjoint with: EV EX Met Enz Inhibit CYP450 Material
disjoint with: EV EX Met Enz Inhibit Data

CYP2E1
type: Class
subclass of: Cytochrome P450
disjoint with: CYP3A4
disjoint with: CYP3A5
disjoint with: Clinical Trial Participants
disjoint with: Drug Drug Interaction
disjoint with: Drug Interaction
disjoint with: Drug Label
disjoint with: Drug Manufacturer
disjoint with: EV CT DDI
disjoint with: EV CT DDI Data
disjoint with: EV CT DDI Material
disjoint with: EV CT PK DDI
disjoint with: EV CT PK DDI Data
disjoint with: EV CT PK DDI Material
disjoint with: EV CT PK Genotype
disjoint with: EV CT PK Genotype Data
disjoint with: EV CT PK Genotype Material
disjoint with: EV CT PK Phenotype
disjoint with: EV CT PK Phenotype Data
disjoint with: EV CT PK Phenotype Material
disjoint with: EV CT Pharmacokinetic
disjoint with: EV CT Pharmacokinetic Data
disjoint with: EV CT Pharmacokinetic Material
disjoint with: EV Case Report
disjoint with: EV Case Report ADE
disjoint with: EV Case Report ADE Data
disjoint with: EV Case Report ADE Material
disjoint with: EV Case Report ADE Public Reported
disjoint with: EV Case Report ADE Public Reported Data
disjoint with: EV Case Report ADE Public Reported Material
disjoint with: EV Case Report DI CR
disjoint with: EV Case Report DI CR Data
disjoint with: EV Case Report DI CR Evaluated
disjoint with: EV Case Report DI CR Evaluated Data
disjoint with: EV Case Report DI CR Evaluated Material
disjoint with: EV Case Report DI CR Material
disjoint with: EV Case Report Data
disjoint with: EV Case Report Material
disjoint with: EV Clinical Trial
disjoint with: EV Clinical Trial Data
disjoint with: EV Clinical Trial Material
disjoint with: EV DrugClinicalReview
disjoint with: EV Drug Review
disjoint with: EV EX Met Enz ID
disjoint with: EV EX Met Enz ID CYP450
disjoint with: EV EX Met Enz ID CYP450 Data
disjoint with: EV EX Met Enz ID CYP450 Hum Liver Microsome
disjoint with: EV EX Met Enz ID CYP450 Hum Liver Microsome Antibody
disjoint with: EV EX Met Enz ID CYP450 Hum Liver Microsome Antibody Data
disjoint with: EV EX Met Enz ID CYP450 Hum Liver Microsome Antibody Material
disjoint with: EV EX Met Enz ID CYP450 Hum Liver Microsome Chem
disjoint with: EV EX Met Enz ID CYP450 Hum Liver Microsome Chem Data
disjoint with: EV EX Met Enz ID CYP450 Hum Liver Microsome Chem Material
disjoint with: EV EX Met Enz ID CYP450 Hum Liver Microsome Data
disjoint with: EV EX Met Enz ID CYP450 Hum Liver Microsome Material
disjoint with: EV EX Met Enz ID CYP450 Hum Recom
disjoint with: EV EX Met Enz ID CYP450 Hum Recom Antibody
disjoint with: EV EX Met Enz ID CYP450 Hum Recom Antibody Data
disjoint with: EV EX Met Enz ID CYP450 Hum Recom Antibody Material
disjoint with: EV EX Met Enz ID CYP450 Hum Recom Chem
disjoint with: EV EX Met Enz ID CYP450 Hum Recom Chem Data
disjoint with: EV EX Met Enz ID CYP450 Hum Recom Chem Material
disjoint with: EV EX Met Enz ID CYP450 Hum Recom Data
disjoint with: EV EX Met Enz ID CYP450 Hum Recom Material
disjoint with: EV EX Met Enz ID CYP450 Material
disjoint with: EV EX Met Enz ID Data
disjoint with: EV EX Met Enz ID Material
disjoint with: EV EX Met Enz Inhibit
disjoint with: EV EX Met Enz Inhibit CYP450
disjoint with: EV EX Met Enz Inhibit CYP450 Data
disjoint with: EV EX Met Enz Inhibit CYP450 Human Liver Microsome
disjoint with: EV EX Met Enz Inhibit CYP450 Human Liver Microsome Data
disjoint with: EV EX Met Enz Inhibit CYP450 Human Liver Microsome Material
disjoint with: EV EX Met Enz Inhibit CYP450 Human Recom
disjoint with: EV EX Met Enz Inhibit CYP450 Human Recom Data
disjoint with: EV EX Met Enz Inhibit CYP450 Human Recom Material
disjoint with: EV EX Met Enz Inhibit CYP450 Material
disjoint with: EV EX Met Enz Inhibit Data
disjoint with: EV EX Met Enz Inhibit Material

CYP3A4
type: Class
subclass of: Cytochrome P450
disjoint with: CYP3A5
disjoint with: Clinical Trial Participants
disjoint with: Drug Drug Interaction
disjoint with: Drug Interaction
disjoint with: Drug Label
disjoint with: Drug Manufacturer
disjoint with: EV CT DDI
disjoint with: EV CT DDI Data
disjoint with: EV CT DDI Material
disjoint with: EV CT PK DDI
disjoint with: EV CT PK DDI Data
disjoint with: EV CT PK DDI Material
disjoint with: EV CT PK Genotype
disjoint with: EV CT PK Genotype Data
disjoint with: EV CT PK Genotype Material
disjoint with: EV CT PK Phenotype
disjoint with: EV CT PK Phenotype Data
disjoint with: EV CT PK Phenotype Material
disjoint with: EV CT Pharmacokinetic
disjoint with: EV CT Pharmacokinetic Data
disjoint with: EV CT Pharmacokinetic Material
disjoint with: EV Case Report
disjoint with: EV Case Report ADE
disjoint with: EV Case Report ADE Data
disjoint with: EV Case Report ADE Material
disjoint with: EV Case Report ADE Public Reported
disjoint with: EV Case Report ADE Public Reported Data
disjoint with: EV Case Report ADE Public Reported Material
disjoint with: EV Case Report DI CR
disjoint with: EV Case Report DI CR Data
disjoint with: EV Case Report DI CR Evaluated
disjoint with: EV Case Report DI CR Evaluated Data
disjoint with: EV Case Report DI CR Evaluated Material
disjoint with: EV Case Report DI CR Material
disjoint with: EV Case Report Data
disjoint with: EV Case Report Material
disjoint with: EV Clinical Trial
disjoint with: EV Clinical Trial Data
disjoint with: EV Clinical Trial Material
disjoint with: EV DrugClinicalReview
disjoint with: EV Drug Review
disjoint with: EV EX Met Enz ID
disjoint with: EV EX Met Enz ID CYP450
disjoint with: EV EX Met Enz ID CYP450 Data
disjoint with: EV EX Met Enz ID CYP450 Hum Liver Microsome
disjoint with: EV EX Met Enz ID CYP450 Hum Liver Microsome Antibody
disjoint with: EV EX Met Enz ID CYP450 Hum Liver Microsome Antibody Data
disjoint with: EV EX Met Enz ID CYP450 Hum Liver Microsome Antibody Material
disjoint with: EV EX Met Enz ID CYP450 Hum Liver Microsome Chem
disjoint with: EV EX Met Enz ID CYP450 Hum Liver Microsome Chem Data
disjoint with: EV EX Met Enz ID CYP450 Hum Liver Microsome Chem Material
disjoint with: EV EX Met Enz ID CYP450 Hum Liver Microsome Data
disjoint with: EV EX Met Enz ID CYP450 Hum Liver Microsome Material
disjoint with: EV EX Met Enz ID CYP450 Hum Recom
disjoint with: EV EX Met Enz ID CYP450 Hum Recom Antibody
disjoint with: EV EX Met Enz ID CYP450 Hum Recom Antibody Data
disjoint with: EV EX Met Enz ID CYP450 Hum Recom Antibody Material
disjoint with: EV EX Met Enz ID CYP450 Hum Recom Chem
disjoint with: EV EX Met Enz ID CYP450 Hum Recom Chem Data
disjoint with: EV EX Met Enz ID CYP450 Hum Recom Chem Material
disjoint with: EV EX Met Enz ID CYP450 Hum Recom Data
disjoint with: EV EX Met Enz ID CYP450 Hum Recom Material
disjoint with: EV EX Met Enz ID CYP450 Material
disjoint with: EV EX Met Enz ID Data
disjoint with: EV EX Met Enz ID Material
disjoint with: EV EX Met Enz Inhibit
disjoint with: EV EX Met Enz Inhibit CYP450
disjoint with: EV EX Met Enz Inhibit CYP450 Data
disjoint with: EV EX Met Enz Inhibit CYP450 Human Liver Microsome
disjoint with: EV EX Met Enz Inhibit CYP450 Human Liver Microsome Data
disjoint with: EV EX Met Enz Inhibit CYP450 Human Liver Microsome Material
disjoint with: EV EX Met Enz Inhibit CYP450 Human Recom
disjoint with: EV EX Met Enz Inhibit CYP450 Human Recom Data
disjoint with: EV EX Met Enz Inhibit CYP450 Human Recom Material
disjoint with: EV EX Met Enz Inhibit CYP450 Material
disjoint with: EV EX Met Enz Inhibit Data
disjoint with: EV EX Met Enz Inhibit Material
disjoint with: EV Non Traceable Statement

CYP3A5
type: Class
subclass of: Cytochrome P450
disjoint with: Clinical Trial Participants
disjoint with: Drug Drug Interaction
disjoint with: Drug Interaction
disjoint with: Drug Label
disjoint with: Drug Manufacturer
disjoint with: EV CT DDI
disjoint with: EV CT DDI Data
disjoint with: EV CT DDI Material
disjoint with: EV CT PK DDI
disjoint with: EV CT PK DDI Data
disjoint with: EV CT PK DDI Material
disjoint with: EV CT PK Genotype
disjoint with: EV CT PK Genotype Data
disjoint with: EV CT PK Genotype Material
disjoint with: EV CT PK Phenotype
disjoint with: EV CT PK Phenotype Data
disjoint with: EV CT PK Phenotype Material
disjoint with: EV CT Pharmacokinetic
disjoint with: EV CT Pharmacokinetic Data
disjoint with: EV CT Pharmacokinetic Material
disjoint with: EV Case Report
disjoint with: EV Case Report ADE
disjoint with: EV Case Report ADE Data
disjoint with: EV Case Report ADE Material
disjoint with: EV Case Report ADE Public Reported
disjoint with: EV Case Report ADE Public Reported Data
disjoint with: EV Case Report ADE Public Reported Material
disjoint with: EV Case Report DI CR
disjoint with: EV Case Report DI CR Data
disjoint with: EV Case Report DI CR Evaluated
disjoint with: EV Case Report DI CR Evaluated Data
disjoint with: EV Case Report DI CR Evaluated Material
disjoint with: EV Case Report DI CR Material
disjoint with: EV Case Report Data
disjoint with: EV Case Report Material
disjoint with: EV Clinical Trial
disjoint with: EV Clinical Trial Data
disjoint with: EV Clinical Trial Material
disjoint with: EV DrugClinicalReview
disjoint with: EV Drug Review
disjoint with: EV EX Met Enz ID
disjoint with: EV EX Met Enz ID CYP450
disjoint with: EV EX Met Enz ID CYP450 Data
disjoint with: EV EX Met Enz ID CYP450 Hum Liver Microsome
disjoint with: EV EX Met Enz ID CYP450 Hum Liver Microsome Antibody
disjoint with: EV EX Met Enz ID CYP450 Hum Liver Microsome Antibody Data
disjoint with: EV EX Met Enz ID CYP450 Hum Liver Microsome Antibody Material
disjoint with: EV EX Met Enz ID CYP450 Hum Liver Microsome Chem
disjoint with: EV EX Met Enz ID CYP450 Hum Liver Microsome Chem Data
disjoint with: EV EX Met Enz ID CYP450 Hum Liver Microsome Chem Material
disjoint with: EV EX Met Enz ID CYP450 Hum Liver Microsome Data
disjoint with: EV EX Met Enz ID CYP450 Hum Liver Microsome Material
disjoint with: EV EX Met Enz ID CYP450 Hum Recom
disjoint with: EV EX Met Enz ID CYP450 Hum Recom Antibody
disjoint with: EV EX Met Enz ID CYP450 Hum Recom Antibody Data
disjoint with: EV EX Met Enz ID CYP450 Hum Recom Antibody Material
disjoint with: EV EX Met Enz ID CYP450 Hum Recom Chem
disjoint with: EV EX Met Enz ID CYP450 Hum Recom Chem Data
disjoint with: EV EX Met Enz ID CYP450 Hum Recom Chem Material
disjoint with: EV EX Met Enz ID CYP450 Hum Recom Data
disjoint with: EV EX Met Enz ID CYP450 Hum Recom Material
disjoint with: EV EX Met Enz ID CYP450 Material
disjoint with: EV EX Met Enz ID Data
disjoint with: EV EX Met Enz ID Material
disjoint with: EV EX Met Enz Inhibit
disjoint with: EV EX Met Enz Inhibit CYP450
disjoint with: EV EX Met Enz Inhibit CYP450 Data
disjoint with: EV EX Met Enz Inhibit CYP450 Human Liver Microsome
disjoint with: EV EX Met Enz Inhibit CYP450 Human Liver Microsome Data
disjoint with: EV EX Met Enz Inhibit CYP450 Human Liver Microsome Material
disjoint with: EV EX Met Enz Inhibit CYP450 Human Recom
disjoint with: EV EX Met Enz Inhibit CYP450 Human Recom Data
disjoint with: EV EX Met Enz Inhibit CYP450 Human Recom Material
disjoint with: EV EX Met Enz Inhibit CYP450 Material
disjoint with: EV EX Met Enz Inhibit Data
disjoint with: EV EX Met Enz Inhibit Material
disjoint with: EV Non Traceable Statement
disjoint with: EV Observational

Cellular Metabolism
type: Class
subclass of: Metabolism
disjoint with: Clinical Trial Participants
disjoint with: Decreased Drug AUC
disjoint with: Decreased Drug Level
disjoint with: Drug
disjoint with: Drug Drug Interaction
disjoint with: Drug Interaction
disjoint with: Drug Label
disjoint with: Drug Manufacturer
disjoint with: EV CT DDI
disjoint with: EV CT DDI Data
disjoint with: EV CT DDI Material
disjoint with: EV CT PK DDI
disjoint with: EV CT PK DDI Data
disjoint with: EV CT PK DDI Material
disjoint with: EV CT PK Genotype
disjoint with: EV CT PK Genotype Data
disjoint with: EV CT PK Genotype Material
disjoint with: EV CT PK Phenotype
disjoint with: EV CT PK Phenotype Data
disjoint with: EV CT PK Phenotype Material
disjoint with: EV CT Pharmacokinetic
disjoint with: EV CT Pharmacokinetic Data
disjoint with: EV CT Pharmacokinetic Material
disjoint with: EV Case Report
disjoint with: EV Case Report ADE
disjoint with: EV Case Report ADE Data
disjoint with: EV Case Report ADE Material
disjoint with: EV Case Report ADE Public Reported
disjoint with: EV Case Report ADE Public Reported Data
disjoint with: EV Case Report ADE Public Reported Material
disjoint with: EV Case Report DI CR
disjoint with: EV Case Report DI CR Data
disjoint with: EV Case Report DI CR Evaluated
disjoint with: EV Case Report DI CR Evaluated Data
disjoint with: EV Case Report DI CR Evaluated Material
disjoint with: EV Case Report DI CR Material
disjoint with: EV Case Report Data
disjoint with: EV Case Report Material
disjoint with: EV Clinical Trial
disjoint with: EV Clinical Trial Data
disjoint with: EV Clinical Trial Material
disjoint with: EV DrugClinicalReview
disjoint with: EV Drug Review
disjoint with: EV EX Met Enz ID
disjoint with: EV EX Met Enz ID CYP450
disjoint with: EV EX Met Enz ID CYP450 Data
disjoint with: EV EX Met Enz ID CYP450 Hum Liver Microsome
disjoint with: EV EX Met Enz ID CYP450 Hum Liver Microsome Antibody
disjoint with: EV EX Met Enz ID CYP450 Hum Liver Microsome Antibody Data
disjoint with: EV EX Met Enz ID CYP450 Hum Liver Microsome Antibody Material
disjoint with: EV EX Met Enz ID CYP450 Hum Liver Microsome Chem
disjoint with: EV EX Met Enz ID CYP450 Hum Liver Microsome Chem Data
disjoint with: EV EX Met Enz ID CYP450 Hum Liver Microsome Chem Material
disjoint with: EV EX Met Enz ID CYP450 Hum Liver Microsome Data
disjoint with: EV EX Met Enz ID CYP450 Hum Liver Microsome Material
disjoint with: EV EX Met Enz ID CYP450 Hum Recom
disjoint with: EV EX Met Enz ID CYP450 Hum Recom Antibody
disjoint with: EV EX Met Enz ID CYP450 Hum Recom Antibody Data
disjoint with: EV EX Met Enz ID CYP450 Hum Recom Antibody Material
disjoint with: EV EX Met Enz ID CYP450 Hum Recom Chem
disjoint with: EV EX Met Enz ID CYP450 Hum Recom Chem Data
disjoint with: EV EX Met Enz ID CYP450 Hum Recom Chem Material
disjoint with: EV EX Met Enz ID CYP450 Hum Recom Data
disjoint with: EV EX Met Enz ID CYP450 Hum Recom Material
disjoint with: EV EX Met Enz ID CYP450 Material
disjoint with: EV EX Met Enz ID Data
disjoint with: EV EX Met Enz ID Material
disjoint with: EV EX Met Enz Inhibit
disjoint with: EV EX Met Enz Inhibit CYP450
disjoint with: EV EX Met Enz Inhibit CYP450 Data
disjoint with: EV EX Met Enz Inhibit CYP450 Human Liver Microsome
disjoint with: EV EX Met Enz Inhibit CYP450 Human Liver Microsome Data
disjoint with: EV EX Met Enz Inhibit CYP450 Human Liver Microsome Material
disjoint with: EV EX Met Enz Inhibit CYP450 Human Recom
disjoint with: EV EX Met Enz Inhibit CYP450 Human Recom Data
disjoint with: EV EX Met Enz Inhibit CYP450 Human Recom Material
disjoint with: EV EX Met Enz Inhibit CYP450 Material
disjoint with: EV EX Met Enz Inhibit Data

Clinical Trial Participants
type: Class
disjoint with: Cytochrome P450
disjoint with: Decreased Drug AUC
disjoint with: Decreased Drug Level
disjoint with: Drug
disjoint with: Drug Absorption
disjoint with: Drug Distribution
disjoint with: Drug Drug Interaction
disjoint with: Drug Excretion
disjoint with: Drug Interaction
disjoint with: Drug Label
disjoint with: Drug Manufacturer
disjoint with: Drug Metabolism
disjoint with: EV CT DDI
disjoint with: EV CT DDI Data
disjoint with: EV CT DDI Material
disjoint with: EV CT PK DDI
disjoint with: EV CT PK DDI Data
disjoint with: EV CT PK DDI Material
disjoint with: EV CT PK Genotype
disjoint with: EV CT PK Genotype Data
disjoint with: EV CT PK Genotype Material
disjoint with: EV CT PK Phenotype
disjoint with: EV CT PK Phenotype Data
disjoint with: EV CT PK Phenotype Material
disjoint with: EV CT Pharmacokinetic
disjoint with: EV CT Pharmacokinetic Data
disjoint with: EV CT Pharmacokinetic Material
disjoint with: EV Case Report
disjoint with: EV Case Report ADE
disjoint with: EV Case Report ADE Data
disjoint with: EV Case Report ADE Material
disjoint with: EV Case Report ADE Public Reported
disjoint with: EV Case Report ADE Public Reported Data
disjoint with: EV Case Report ADE Public Reported Material
disjoint with: EV Case Report DI CR
disjoint with: EV Case Report DI CR Data
disjoint with: EV Case Report DI CR Evaluated
disjoint with: EV Case Report DI CR Evaluated Data
disjoint with: EV Case Report DI CR Evaluated Material
disjoint with: EV Case Report DI CR Material
disjoint with: EV Case Report Data
disjoint with: EV Case Report Material
disjoint with: EV Clinical Trial
disjoint with: EV Clinical Trial Data
disjoint with: EV Clinical Trial Material
disjoint with: EV DrugClinicalReview
disjoint with: EV Drug Review
disjoint with: EV EX Met Enz ID
disjoint with: EV EX Met Enz ID CYP450
disjoint with: EV EX Met Enz ID CYP450 Data
disjoint with: EV EX Met Enz ID CYP450 Hum Liver Microsome
disjoint with: EV EX Met Enz ID CYP450 Hum Liver Microsome Antibody
disjoint with: EV EX Met Enz ID CYP450 Hum Liver Microsome Antibody Data
disjoint with: EV EX Met Enz ID CYP450 Hum Liver Microsome Antibody Material
disjoint with: EV EX Met Enz ID CYP450 Hum Liver Microsome Chem
disjoint with: EV EX Met Enz ID CYP450 Hum Liver Microsome Chem Data
disjoint with: EV EX Met Enz ID CYP450 Hum Liver Microsome Chem Material
disjoint with: EV EX Met Enz ID CYP450 Hum Liver Microsome Data
disjoint with: EV EX Met Enz ID CYP450 Hum Liver Microsome Material
disjoint with: EV EX Met Enz ID CYP450 Hum Recom
disjoint with: EV EX Met Enz ID CYP450 Hum Recom Antibody
disjoint with: EV EX Met Enz ID CYP450 Hum Recom Antibody Data
disjoint with: EV EX Met Enz ID CYP450 Hum Recom Antibody Material
disjoint with: EV EX Met Enz ID CYP450 Hum Recom Chem
disjoint with: EV EX Met Enz ID CYP450 Hum Recom Chem Data
disjoint with: EV EX Met Enz ID CYP450 Hum Recom Chem Material
disjoint with: EV EX Met Enz ID CYP450 Hum Recom Data
disjoint with: EV EX Met Enz ID CYP450 Hum Recom Material
disjoint with: EV EX Met Enz ID CYP450 Material
disjoint with: EV EX Met Enz ID Data
disjoint with: EV EX Met Enz ID Material
disjoint with: EV EX Met Enz Inhibit
disjoint with: EV EX Met Enz Inhibit CYP450
disjoint with: EV EX Met Enz Inhibit CYP450 Data
disjoint with: EV EX Met Enz Inhibit CYP450 Human Liver Microsome
disjoint with: EV EX Met Enz Inhibit CYP450 Human Liver Microsome Data
disjoint with: EV EX Met Enz Inhibit CYP450 Human Liver Microsome Material
disjoint with: EV EX Met Enz Inhibit CYP450 Human Recom
disjoint with: EV EX Met Enz Inhibit CYP450 Human Recom Data

Cytochrome P450
type: Class
subclass of: Enzyme
subclass of: Protein
disjoint with: Drug Drug Interaction
disjoint with: Drug Interaction
disjoint with: Drug Label
disjoint with: Drug Manufacturer
disjoint with: EV CT DDI
disjoint with: EV CT DDI Data
disjoint with: EV CT DDI Material
disjoint with: EV CT PK DDI
disjoint with: EV CT PK DDI Data
disjoint with: EV CT PK DDI Material
disjoint with: EV CT PK Genotype
disjoint with: EV CT PK Genotype Data
disjoint with: EV CT PK Genotype Material
disjoint with: EV CT PK Phenotype
disjoint with: EV CT PK Phenotype Data
disjoint with: EV CT PK Phenotype Material
disjoint with: EV CT Pharmacokinetic
disjoint with: EV CT Pharmacokinetic Data
disjoint with: EV CT Pharmacokinetic Material
disjoint with: EV Case Report
disjoint with: EV Case Report ADE
disjoint with: EV Case Report ADE Data
disjoint with: EV Case Report ADE Material
disjoint with: EV Case Report ADE Public Reported
disjoint with: EV Case Report ADE Public Reported Data
disjoint with: EV Case Report ADE Public Reported Material
disjoint with: EV Case Report DI CR
disjoint with: EV Case Report DI CR Data
disjoint with: EV Case Report DI CR Evaluated
disjoint with: EV Case Report DI CR Evaluated Data
disjoint with: EV Case Report DI CR Evaluated Material
disjoint with: EV Case Report DI CR Material
disjoint with: EV Case Report Data
disjoint with: EV Case Report Material
disjoint with: EV Clinical Trial
disjoint with: EV Clinical Trial Data
disjoint with: EV Clinical Trial Material
disjoint with: EV DrugClinicalReview
disjoint with: EV Drug Review
disjoint with: EV EX Met Enz ID
disjoint with: EV EX Met Enz ID CYP450
disjoint with: EV EX Met Enz ID CYP450 Data
disjoint with: EV EX Met Enz ID CYP450 Hum Liver Microsome
disjoint with: EV EX Met Enz ID CYP450 Hum Liver Microsome Antibody
disjoint with: EV EX Met Enz ID CYP450 Hum Liver Microsome Antibody Data
disjoint with: EV EX Met Enz ID CYP450 Hum Liver Microsome Antibody Material
disjoint with: EV EX Met Enz ID CYP450 Hum Liver Microsome Chem
disjoint with: EV EX Met Enz ID CYP450 Hum Liver Microsome Chem Data
disjoint with: EV EX Met Enz ID CYP450 Hum Liver Microsome Chem Material
disjoint with: EV EX Met Enz ID CYP450 Hum Liver Microsome Data
disjoint with: EV EX Met Enz ID CYP450 Hum Liver Microsome Material
disjoint with: EV EX Met Enz ID CYP450 Hum Recom
disjoint with: EV EX Met Enz ID CYP450 Hum Recom Antibody
disjoint with: EV EX Met Enz ID CYP450 Hum Recom Antibody Data
disjoint with: EV EX Met Enz ID CYP450 Hum Recom Antibody Material
disjoint with: EV EX Met Enz ID CYP450 Hum Recom Chem
disjoint with: EV EX Met Enz ID CYP450 Hum Recom Chem Data
disjoint with: EV EX Met Enz ID CYP450 Hum Recom Chem Material
disjoint with: EV EX Met Enz ID CYP450 Hum Recom Data
disjoint with: EV EX Met Enz ID CYP450 Hum Recom Material
disjoint with: EV EX Met Enz ID CYP450 Material
disjoint with: EV EX Met Enz ID Data
disjoint with: EV EX Met Enz ID Material
disjoint with: EV EX Met Enz Inhibit
disjoint with: EV EX Met Enz Inhibit CYP450
disjoint with: EV EX Met Enz Inhibit CYP450 Data
disjoint with: EV EX Met Enz Inhibit CYP450 Human Liver Microsome
disjoint with: EV EX Met Enz Inhibit CYP450 Human Liver Microsome Data
disjoint with: EV EX Met Enz Inhibit CYP450 Human Liver Microsome Material
disjoint with: EV EX Met Enz Inhibit CYP450 Human Recom
disjoint with: EV EX Met Enz Inhibit CYP450 Human Recom Data
disjoint with: EV EX Met Enz Inhibit CYP450 Human Recom Material
disjoint with: EV EX Met Enz Inhibit CYP450 Material
disjoint with: EV EX Met Enz Inhibit Data
disjoint with: EV EX Met Enz Inhibit Material
disjoint with: EV Non Traceable Statement
disjoint with: EV Observational

Decreased Drug AUC
type: Class
subclass of: Decreased Drug Level
disjoint with: Drug
disjoint with: Drug Absorption
disjoint with: Drug Distribution
disjoint with: Drug Drug Interaction
disjoint with: Drug Excretion
disjoint with: Drug Interaction
disjoint with: Drug Label
disjoint with: Drug Manufacturer
disjoint with: Drug Metabolism
disjoint with: EV CT DDI
disjoint with: EV CT DDI Data
disjoint with: EV CT DDI Material
disjoint with: EV CT PK DDI
disjoint with: EV CT PK DDI Data
disjoint with: EV CT PK DDI Material
disjoint with: EV CT PK Genotype
disjoint with: EV CT PK Genotype Data
disjoint with: EV CT PK Genotype Material
disjoint with: EV CT PK Phenotype
disjoint with: EV CT PK Phenotype Data
disjoint with: EV CT PK Phenotype Material
disjoint with: EV CT Pharmacokinetic
disjoint with: EV CT Pharmacokinetic Data
disjoint with: EV CT Pharmacokinetic Material
disjoint with: EV Case Report
disjoint with: EV Case Report ADE
disjoint with: EV Case Report ADE Data
disjoint with: EV Case Report ADE Material
disjoint with: EV Case Report ADE Public Reported
disjoint with: EV Case Report ADE Public Reported Data
disjoint with: EV Case Report ADE Public Reported Material
disjoint with: EV Case Report DI CR
disjoint with: EV Case Report DI CR Data
disjoint with: EV Case Report DI CR Evaluated
disjoint with: EV Case Report DI CR Evaluated Data
disjoint with: EV Case Report DI CR Evaluated Material
disjoint with: EV Case Report DI CR Material
disjoint with: EV Case Report Data
disjoint with: EV Case Report Material
disjoint with: EV Clinical Trial
disjoint with: EV Clinical Trial Data
disjoint with: EV Clinical Trial Material
disjoint with: EV DrugClinicalReview
disjoint with: EV Drug Review
disjoint with: EV EX Met Enz ID
disjoint with: EV EX Met Enz ID CYP450
disjoint with: EV EX Met Enz ID CYP450 Data
disjoint with: EV EX Met Enz ID CYP450 Hum Liver Microsome
disjoint with: EV EX Met Enz ID CYP450 Hum Liver Microsome Antibody
disjoint with: EV EX Met Enz ID CYP450 Hum Liver Microsome Antibody Data
disjoint with: EV EX Met Enz ID CYP450 Hum Liver Microsome Antibody Material
disjoint with: EV EX Met Enz ID CYP450 Hum Liver Microsome Chem
disjoint with: EV EX Met Enz ID CYP450 Hum Liver Microsome Chem Data
disjoint with: EV EX Met Enz ID CYP450 Hum Liver Microsome Chem Material
disjoint with: EV EX Met Enz ID CYP450 Hum Liver Microsome Data
disjoint with: EV EX Met Enz ID CYP450 Hum Liver Microsome Material
disjoint with: EV EX Met Enz ID CYP450 Hum Recom
disjoint with: EV EX Met Enz ID CYP450 Hum Recom Antibody
disjoint with: EV EX Met Enz ID CYP450 Hum Recom Antibody Data
disjoint with: EV EX Met Enz ID CYP450 Hum Recom Antibody Material
disjoint with: EV EX Met Enz ID CYP450 Hum Recom Chem
disjoint with: EV EX Met Enz ID CYP450 Hum Recom Chem Data
disjoint with: EV EX Met Enz ID CYP450 Hum Recom Chem Material
disjoint with: EV EX Met Enz ID CYP450 Hum Recom Data
disjoint with: EV EX Met Enz ID CYP450 Hum Recom Material
disjoint with: EV EX Met Enz ID CYP450 Material
disjoint with: EV EX Met Enz ID Data
disjoint with: EV EX Met Enz ID Material
disjoint with: EV EX Met Enz Inhibit
disjoint with: EV EX Met Enz Inhibit CYP450
disjoint with: EV EX Met Enz Inhibit CYP450 Data
disjoint with: EV EX Met Enz Inhibit CYP450 Human Liver Microsome
disjoint with: EV EX Met Enz Inhibit CYP450 Human Liver Microsome Data
disjoint with: EV EX Met Enz Inhibit CYP450 Human Liver Microsome Material
disjoint with: EV EX Met Enz Inhibit CYP450 Human Recom
disjoint with: EV EX Met Enz Inhibit CYP450 Human Recom Data
disjoint with: EV EX Met Enz Inhibit CYP450 Human Recom Material
disjoint with: EV EX Met Enz Inhibit CYP450 Material

Decreased Drug Level
type: Class
subclass of: Pharmacokinetic Effect Consequences
disjoint with: Drug
disjoint with: Drug Absorption
disjoint with: Drug Distribution
disjoint with: Drug Drug Interaction
disjoint with: Drug Excretion
disjoint with: Drug Interaction
disjoint with: Drug Label
disjoint with: Drug Manufacturer
disjoint with: Drug Metabolism
disjoint with: EV CT DDI
disjoint with: EV CT DDI Data
disjoint with: EV CT DDI Material
disjoint with: EV CT PK DDI
disjoint with: EV CT PK DDI Data
disjoint with: EV CT PK DDI Material
disjoint with: EV CT PK Genotype
disjoint with: EV CT PK Genotype Data
disjoint with: EV CT PK Genotype Material
disjoint with: EV CT PK Phenotype
disjoint with: EV CT PK Phenotype Data
disjoint with: EV CT PK Phenotype Material
disjoint with: EV CT Pharmacokinetic
disjoint with: EV CT Pharmacokinetic Data
disjoint with: EV CT Pharmacokinetic Material
disjoint with: EV Case Report
disjoint with: EV Case Report ADE
disjoint with: EV Case Report ADE Data
disjoint with: EV Case Report ADE Material
disjoint with: EV Case Report ADE Public Reported
disjoint with: EV Case Report ADE Public Reported Data
disjoint with: EV Case Report ADE Public Reported Material
disjoint with: EV Case Report DI CR
disjoint with: EV Case Report DI CR Data
disjoint with: EV Case Report DI CR Evaluated
disjoint with: EV Case Report DI CR Evaluated Data
disjoint with: EV Case Report DI CR Evaluated Material
disjoint with: EV Case Report DI CR Material
disjoint with: EV Case Report Data
disjoint with: EV Case Report Material
disjoint with: EV Clinical Trial
disjoint with: EV Clinical Trial Data
disjoint with: EV Clinical Trial Material
disjoint with: EV DrugClinicalReview
disjoint with: EV Drug Review
disjoint with: EV EX Met Enz ID
disjoint with: EV EX Met Enz ID CYP450
disjoint with: EV EX Met Enz ID CYP450 Data
disjoint with: EV EX Met Enz ID CYP450 Hum Liver Microsome
disjoint with: EV EX Met Enz ID CYP450 Hum Liver Microsome Antibody
disjoint with: EV EX Met Enz ID CYP450 Hum Liver Microsome Antibody Data
disjoint with: EV EX Met Enz ID CYP450 Hum Liver Microsome Antibody Material
disjoint with: EV EX Met Enz ID CYP450 Hum Liver Microsome Chem
disjoint with: EV EX Met Enz ID CYP450 Hum Liver Microsome Chem Data
disjoint with: EV EX Met Enz ID CYP450 Hum Liver Microsome Chem Material
disjoint with: EV EX Met Enz ID CYP450 Hum Liver Microsome Data
disjoint with: EV EX Met Enz ID CYP450 Hum Liver Microsome Material
disjoint with: EV EX Met Enz ID CYP450 Hum Recom
disjoint with: EV EX Met Enz ID CYP450 Hum Recom Antibody
disjoint with: EV EX Met Enz ID CYP450 Hum Recom Antibody Data
disjoint with: EV EX Met Enz ID CYP450 Hum Recom Antibody Material
disjoint with: EV EX Met Enz ID CYP450 Hum Recom Chem
disjoint with: EV EX Met Enz ID CYP450 Hum Recom Chem Data
disjoint with: EV EX Met Enz ID CYP450 Hum Recom Chem Material
disjoint with: EV EX Met Enz ID CYP450 Hum Recom Data
disjoint with: EV EX Met Enz ID CYP450 Hum Recom Material
disjoint with: EV EX Met Enz ID CYP450 Material
disjoint with: EV EX Met Enz ID Data
disjoint with: EV EX Met Enz ID Material
disjoint with: EV EX Met Enz Inhibit
disjoint with: EV EX Met Enz Inhibit CYP450
disjoint with: EV EX Met Enz Inhibit CYP450 Data
disjoint with: EV EX Met Enz Inhibit CYP450 Human Liver Microsome
disjoint with: EV EX Met Enz Inhibit CYP450 Human Liver Microsome Data
disjoint with: EV EX Met Enz Inhibit CYP450 Human Liver Microsome Material
disjoint with: EV EX Met Enz Inhibit CYP450 Human Recom
disjoint with: EV EX Met Enz Inhibit CYP450 Human Recom Data
disjoint with: EV EX Met Enz Inhibit CYP450 Human Recom Material
disjoint with: EV EX Met Enz Inhibit CYP450 Material

Drug
type: Class
subclass of: Thing
disjoint with: Drug Absorption
disjoint with: Drug Distribution
disjoint with: Drug Drug Interaction
disjoint with: Drug Excretion
disjoint with: Drug Interaction
disjoint with: Drug Label
disjoint with: Drug Manufacturer
disjoint with: Drug Metabolism
disjoint with: EV CT DDI
disjoint with: EV CT DDI Data
disjoint with: EV CT DDI Material
disjoint with: EV CT PK DDI
disjoint with: EV CT PK DDI Data
disjoint with: EV CT PK DDI Material
disjoint with: EV CT PK Genotype
disjoint with: EV CT PK Genotype Data
disjoint with: EV CT PK Genotype Material
disjoint with: EV CT PK Phenotype
disjoint with: EV CT PK Phenotype Data
disjoint with: EV CT PK Phenotype Material
disjoint with: EV CT Pharmacokinetic
disjoint with: EV CT Pharmacokinetic Data
disjoint with: EV CT Pharmacokinetic Material
disjoint with: EV Case Report
disjoint with: EV Case Report ADE
disjoint with: EV Case Report ADE Data
disjoint with: EV Case Report ADE Material
disjoint with: EV Case Report ADE Public Reported
disjoint with: EV Case Report ADE Public Reported Data
disjoint with: EV Case Report ADE Public Reported Material
disjoint with: EV Case Report DI CR
disjoint with: EV Case Report DI CR Data
disjoint with: EV Case Report DI CR Evaluated
disjoint with: EV Case Report DI CR Evaluated Data
disjoint with: EV Case Report DI CR Evaluated Material
disjoint with: EV Case Report DI CR Material
disjoint with: EV Case Report Data
disjoint with: EV Case Report Material
disjoint with: EV Clinical Trial
disjoint with: EV Clinical Trial Data
disjoint with: EV Clinical Trial Material
disjoint with: EV DrugClinicalReview
disjoint with: EV Drug Review
disjoint with: EV EX Met Enz ID
disjoint with: EV EX Met Enz ID CYP450
disjoint with: EV EX Met Enz ID CYP450 Data
disjoint with: EV EX Met Enz ID CYP450 Hum Liver Microsome
disjoint with: EV EX Met Enz ID CYP450 Hum Liver Microsome Antibody
disjoint with: EV EX Met Enz ID CYP450 Hum Liver Microsome Antibody Data
disjoint with: EV EX Met Enz ID CYP450 Hum Liver Microsome Antibody Material
disjoint with: EV EX Met Enz ID CYP450 Hum Liver Microsome Chem
disjoint with: EV EX Met Enz ID CYP450 Hum Liver Microsome Chem Data
disjoint with: EV EX Met Enz ID CYP450 Hum Liver Microsome Chem Material
disjoint with: EV EX Met Enz ID CYP450 Hum Liver Microsome Data
disjoint with: EV EX Met Enz ID CYP450 Hum Liver Microsome Material
disjoint with: EV EX Met Enz ID CYP450 Hum Recom
disjoint with: EV EX Met Enz ID CYP450 Hum Recom Antibody
disjoint with: EV EX Met Enz ID CYP450 Hum Recom Antibody Data
disjoint with: EV EX Met Enz ID CYP450 Hum Recom Antibody Material
disjoint with: EV EX Met Enz ID CYP450 Hum Recom Chem
disjoint with: EV EX Met Enz ID CYP450 Hum Recom Chem Data
disjoint with: EV EX Met Enz ID CYP450 Hum Recom Chem Material
disjoint with: EV EX Met Enz ID CYP450 Hum Recom Data
disjoint with: EV EX Met Enz ID CYP450 Hum Recom Material
disjoint with: EV EX Met Enz ID CYP450 Material
disjoint with: EV EX Met Enz ID Data
disjoint with: EV EX Met Enz ID Material
disjoint with: EV EX Met Enz Inhibit
disjoint with: EV EX Met Enz Inhibit CYP450
disjoint with: EV EX Met Enz Inhibit CYP450 Data
disjoint with: EV EX Met Enz Inhibit CYP450 Human Liver Microsome
disjoint with: EV EX Met Enz Inhibit CYP450 Human Liver Microsome Data
disjoint with: EV EX Met Enz Inhibit CYP450 Human Liver Microsome Material
disjoint with: EV EX Met Enz Inhibit CYP450 Human Recom
disjoint with: EV EX Met Enz Inhibit CYP450 Human Recom Data
disjoint with: EV EX Met Enz Inhibit CYP450 Human Recom Material
disjoint with: EV EX Met Enz Inhibit CYP450 Material
disjoint with: EV EX Met Enz Inhibit Data

Drug Distribution
type: Class
subclass of: Pharmacokinetic Process
disjoint with: Drug Drug Interaction
disjoint with: Drug Excretion
disjoint with: Drug Interaction
disjoint with: Drug Label
disjoint with: Drug Manufacturer
disjoint with: Drug Metabolism
disjoint with: EV CT DDI
disjoint with: EV CT DDI Data
disjoint with: EV CT DDI Material
disjoint with: EV CT PK DDI
disjoint with: EV CT PK DDI Data
disjoint with: EV CT PK DDI Material
disjoint with: EV CT PK Genotype
disjoint with: EV CT PK Genotype Data
disjoint with: EV CT PK Genotype Material
disjoint with: EV CT PK Phenotype
disjoint with: EV CT PK Phenotype Data
disjoint with: EV CT PK Phenotype Material
disjoint with: EV CT Pharmacokinetic
disjoint with: EV CT Pharmacokinetic Data
disjoint with: EV CT Pharmacokinetic Material
disjoint with: EV Case Report
disjoint with: EV Case Report ADE
disjoint with: EV Case Report ADE Data
disjoint with: EV Case Report ADE Material
disjoint with: EV Case Report ADE Public Reported
disjoint with: EV Case Report ADE Public Reported Data
disjoint with: EV Case Report ADE Public Reported Material
disjoint with: EV Case Report DI CR
disjoint with: EV Case Report DI CR Data
disjoint with: EV Case Report DI CR Evaluated
disjoint with: EV Case Report DI CR Evaluated Data
disjoint with: EV Case Report DI CR Evaluated Material
disjoint with: EV Case Report DI CR Material
disjoint with: EV Case Report Data
disjoint with: EV Case Report Material
disjoint with: EV Clinical Trial
disjoint with: EV Clinical Trial Data
disjoint with: EV Clinical Trial Material
disjoint with: EV DrugClinicalReview
disjoint with: EV Drug Review
disjoint with: EV EX Met Enz ID
disjoint with: EV EX Met Enz ID CYP450
disjoint with: EV EX Met Enz ID CYP450 Data
disjoint with: EV EX Met Enz ID CYP450 Hum Liver Microsome
disjoint with: EV EX Met Enz ID CYP450 Hum Liver Microsome Antibody
disjoint with: EV EX Met Enz ID CYP450 Hum Liver Microsome Antibody Data
disjoint with: EV EX Met Enz ID CYP450 Hum Liver Microsome Antibody Material
disjoint with: EV EX Met Enz ID CYP450 Hum Liver Microsome Chem
disjoint with: EV EX Met Enz ID CYP450 Hum Liver Microsome Chem Data
disjoint with: EV EX Met Enz ID CYP450 Hum Liver Microsome Chem Material
disjoint with: EV EX Met Enz ID CYP450 Hum Liver Microsome Data
disjoint with: EV EX Met Enz ID CYP450 Hum Liver Microsome Material
disjoint with: EV EX Met Enz ID CYP450 Hum Recom
disjoint with: EV EX Met Enz ID CYP450 Hum Recom Antibody
disjoint with: EV EX Met Enz ID CYP450 Hum Recom Antibody Data
disjoint with: EV EX Met Enz ID CYP450 Hum Recom Antibody Material
disjoint with: EV EX Met Enz ID CYP450 Hum Recom Chem
disjoint with: EV EX Met Enz ID CYP450 Hum Recom Chem Data
disjoint with: EV EX Met Enz ID CYP450 Hum Recom Chem Material
disjoint with: EV EX Met Enz ID CYP450 Hum Recom Data
disjoint with: EV EX Met Enz ID CYP450 Hum Recom Material
disjoint with: EV EX Met Enz ID CYP450 Material
disjoint with: EV EX Met Enz ID Data
disjoint with: EV EX Met Enz ID Material
disjoint with: EV EX Met Enz Inhibit
disjoint with: EV EX Met Enz Inhibit CYP450
disjoint with: EV EX Met Enz Inhibit CYP450 Data
disjoint with: EV EX Met Enz Inhibit CYP450 Human Liver Microsome
disjoint with: EV EX Met Enz Inhibit CYP450 Human Liver Microsome Data
disjoint with: EV EX Met Enz Inhibit CYP450 Human Liver Microsome Material
disjoint with: EV EX Met Enz Inhibit CYP450 Human Recom
disjoint with: EV EX Met Enz Inhibit CYP450 Human Recom Data
disjoint with: EV EX Met Enz Inhibit CYP450 Human Recom Material
disjoint with: EV EX Met Enz Inhibit CYP450 Material
disjoint with: EV EX Met Enz Inhibit Data
disjoint with: EV EX Met Enz Inhibit Material
disjoint with: EV Non Traceable Statement

Drug Drug Interaction
type: Class
subclass of: Drug Interaction
disjoint with: Drug Excretion
disjoint with: Drug Label
disjoint with: Drug Manufacturer
disjoint with: Drug Metabolism
disjoint with: EV CT DDI
disjoint with: EV CT DDI Data
disjoint with: EV CT DDI Material
disjoint with: EV CT PK DDI
disjoint with: EV CT PK DDI Data
disjoint with: EV CT PK DDI Material
disjoint with: EV CT PK Genotype
disjoint with: EV CT PK Genotype Data
disjoint with: EV CT PK Genotype Material
disjoint with: EV CT PK Phenotype
disjoint with: EV CT PK Phenotype Data
disjoint with: EV CT PK Phenotype Material
disjoint with: EV CT Pharmacokinetic
disjoint with: EV CT Pharmacokinetic Data
disjoint with: EV CT Pharmacokinetic Material
disjoint with: EV Case Report
disjoint with: EV Case Report ADE
disjoint with: EV Case Report ADE Data
disjoint with: EV Case Report ADE Material
disjoint with: EV Case Report ADE Public Reported
disjoint with: EV Case Report ADE Public Reported Data
disjoint with: EV Case Report ADE Public Reported Material
disjoint with: EV Case Report DI CR
disjoint with: EV Case Report DI CR Data
disjoint with: EV Case Report DI CR Evaluated
disjoint with: EV Case Report DI CR Evaluated Data
disjoint with: EV Case Report DI CR Evaluated Material
disjoint with: EV Case Report DI CR Material
disjoint with: EV Case Report Data
disjoint with: EV Case Report Material
disjoint with: EV Clinical Trial
disjoint with: EV Clinical Trial Data
disjoint with: EV Clinical Trial Material
disjoint with: EV DrugClinicalReview
disjoint with: EV Drug Review
disjoint with: EV EX Met Enz ID
disjoint with: EV EX Met Enz ID CYP450
disjoint with: EV EX Met Enz ID CYP450 Data
disjoint with: EV EX Met Enz ID CYP450 Hum Liver Microsome
disjoint with: EV EX Met Enz ID CYP450 Hum Liver Microsome Antibody
disjoint with: EV EX Met Enz ID CYP450 Hum Liver Microsome Antibody Data
disjoint with: EV EX Met Enz ID CYP450 Hum Liver Microsome Antibody Material
disjoint with: EV EX Met Enz ID CYP450 Hum Liver Microsome Chem
disjoint with: EV EX Met Enz ID CYP450 Hum Liver Microsome Chem Data
disjoint with: EV EX Met Enz ID CYP450 Hum Liver Microsome Chem Material
disjoint with: EV EX Met Enz ID CYP450 Hum Liver Microsome Data
disjoint with: EV EX Met Enz ID CYP450 Hum Liver Microsome Material
disjoint with: EV EX Met Enz ID CYP450 Hum Recom
disjoint with: EV EX Met Enz ID CYP450 Hum Recom Antibody
disjoint with: EV EX Met Enz ID CYP450 Hum Recom Antibody Data
disjoint with: EV EX Met Enz ID CYP450 Hum Recom Antibody Material
disjoint with: EV EX Met Enz ID CYP450 Hum Recom Chem
disjoint with: EV EX Met Enz ID CYP450 Hum Recom Chem Data
disjoint with: EV EX Met Enz ID CYP450 Hum Recom Chem Material
disjoint with: EV EX Met Enz ID CYP450 Hum Recom Data
disjoint with: EV EX Met Enz ID CYP450 Hum Recom Material
disjoint with: EV EX Met Enz ID CYP450 Material
disjoint with: EV EX Met Enz ID Data
disjoint with: EV EX Met Enz ID Material
disjoint with: EV EX Met Enz Inhibit
disjoint with: EV EX Met Enz Inhibit CYP450
disjoint with: EV EX Met Enz Inhibit CYP450 Data
disjoint with: EV EX Met Enz Inhibit CYP450 Human Liver Microsome
disjoint with: EV EX Met Enz Inhibit CYP450 Human Liver Microsome Data
disjoint with: EV EX Met Enz Inhibit CYP450 Human Liver Microsome Material
disjoint with: EV EX Met Enz Inhibit CYP450 Human Recom
disjoint with: EV EX Met Enz Inhibit CYP450 Human Recom Data
disjoint with: EV EX Met Enz Inhibit CYP450 Human Recom Material
disjoint with: EV EX Met Enz Inhibit CYP450 Material
disjoint with: EV EX Met Enz Inhibit Data
disjoint with: EV EX Met Enz Inhibit Material
disjoint with: EV Non Traceable Statement
disjoint with: EV Observational
disjoint with: EV Observational Data

Drug Interaction
type: Class
subclass of: Thing
disjoint with: Drug Label
disjoint with: Drug Manufacturer
disjoint with: Drug Metabolism
disjoint with: EV CT DDI
disjoint with: EV CT DDI Data
disjoint with: EV CT DDI Material
disjoint with: EV CT PK DDI
disjoint with: EV CT PK DDI Data
disjoint with: EV CT PK DDI Material
disjoint with: EV CT PK Genotype
disjoint with: EV CT PK Genotype Data
disjoint with: EV CT PK Genotype Material
disjoint with: EV CT PK Phenotype
disjoint with: EV CT PK Phenotype Data
disjoint with: EV CT PK Phenotype Material
disjoint with: EV CT Pharmacokinetic
disjoint with: EV CT Pharmacokinetic Data
disjoint with: EV CT Pharmacokinetic Material
disjoint with: EV Case Report
disjoint with: EV Case Report ADE
disjoint with: EV Case Report ADE Data
disjoint with: EV Case Report ADE Material
disjoint with: EV Case Report ADE Public Reported
disjoint with: EV Case Report ADE Public Reported Data
disjoint with: EV Case Report ADE Public Reported Material
disjoint with: EV Case Report DI CR
disjoint with: EV Case Report DI CR Data
disjoint with: EV Case Report DI CR Evaluated
disjoint with: EV Case Report DI CR Evaluated Data
disjoint with: EV Case Report DI CR Evaluated Material
disjoint with: EV Case Report DI CR Material
disjoint with: EV Case Report Data
disjoint with: EV Case Report Material
disjoint with: EV Clinical Trial
disjoint with: EV Clinical Trial Data
disjoint with: EV Clinical Trial Material
disjoint with: EV DrugClinicalReview
disjoint with: EV Drug Review
disjoint with: EV EX Met Enz ID
disjoint with: EV EX Met Enz ID CYP450
disjoint with: EV EX Met Enz ID CYP450 Data
disjoint with: EV EX Met Enz ID CYP450 Hum Liver Microsome
disjoint with: EV EX Met Enz ID CYP450 Hum Liver Microsome Antibody
disjoint with: EV EX Met Enz ID CYP450 Hum Liver Microsome Antibody Data
disjoint with: EV EX Met Enz ID CYP450 Hum Liver Microsome Antibody Material
disjoint with: EV EX Met Enz ID CYP450 Hum Liver Microsome Chem
disjoint with: EV EX Met Enz ID CYP450 Hum Liver Microsome Chem Data
disjoint with: EV EX Met Enz ID CYP450 Hum Liver Microsome Chem Material
disjoint with: EV EX Met Enz ID CYP450 Hum Liver Microsome Data
disjoint with: EV EX Met Enz ID CYP450 Hum Liver Microsome Material
disjoint with: EV EX Met Enz ID CYP450 Hum Recom
disjoint with: EV EX Met Enz ID CYP450 Hum Recom Antibody
disjoint with: EV EX Met Enz ID CYP450 Hum Recom Antibody Data
disjoint with: EV EX Met Enz ID CYP450 Hum Recom Antibody Material
disjoint with: EV EX Met Enz ID CYP450 Hum Recom Chem
disjoint with: EV EX Met Enz ID CYP450 Hum Recom Chem Data
disjoint with: EV EX Met Enz ID CYP450 Hum Recom Chem Material
disjoint with: EV EX Met Enz ID CYP450 Hum Recom Data
disjoint with: EV EX Met Enz ID CYP450 Hum Recom Material
disjoint with: EV EX Met Enz ID CYP450 Material
disjoint with: EV EX Met Enz ID Data
disjoint with: EV EX Met Enz ID Material
disjoint with: EV EX Met Enz Inhibit
disjoint with: EV EX Met Enz Inhibit CYP450
disjoint with: EV EX Met Enz Inhibit CYP450 Data
disjoint with: EV EX Met Enz Inhibit CYP450 Human Liver Microsome
disjoint with: EV EX Met Enz Inhibit CYP450 Human Liver Microsome Data
disjoint with: EV EX Met Enz Inhibit CYP450 Human Liver Microsome Material
disjoint with: EV EX Met Enz Inhibit CYP450 Human Recom
disjoint with: EV EX Met Enz Inhibit CYP450 Human Recom Data
disjoint with: EV EX Met Enz Inhibit CYP450 Human Recom Material
disjoint with: EV EX Met Enz Inhibit CYP450 Material
disjoint with: EV EX Met Enz Inhibit Data
disjoint with: EV EX Met Enz Inhibit Material
disjoint with: EV Non Traceable Statement
disjoint with: EV Observational
disjoint with: EV Observational Data
disjoint with: EV Observational Material

Drug Label
type: Class
subclass of: Evidence Type
disjoint with: Drug Manufacturer
disjoint with: Drug Metabolism
disjoint with: EV CT DDI
disjoint with: EV CT PK DDI
disjoint with: EV CT PK Genotype
disjoint with: EV CT PK Phenotype
disjoint with: EV CT Pharmacokinetic
disjoint with: EV Case Report
disjoint with: EV Case Report ADE
disjoint with: EV Case Report ADE Public Reported
disjoint with: EV Case Report DI CR
disjoint with: EV Case Report DI CR Evaluated
disjoint with: EV Clinical Trial
disjoint with: EV DrugClinicalReview
disjoint with: EV Drug Review
disjoint with: EV EX Met Enz ID
disjoint with: EV EX Met Enz ID CYP450
disjoint with: EV EX Met Enz ID CYP450 Hum Liver Microsome
disjoint with: EV EX Met Enz ID CYP450 Hum Liver Microsome Antibody
disjoint with: EV EX Met Enz ID CYP450 Hum Liver Microsome Chem
disjoint with: EV EX Met Enz ID CYP450 Hum Recom
disjoint with: EV EX Met Enz ID CYP450 Hum Recom Antibody
disjoint with: EV EX Met Enz ID CYP450 Hum Recom Chem
disjoint with: EV EX Met Enz Inhibit
disjoint with: EV EX Met Enz Inhibit CYP450
disjoint with: EV EX Met Enz Inhibit CYP450 Human Liver Microsome
disjoint with: EV EX Met Enz Inhibit CYP450 Human Recom
disjoint with: EV Non Traceable Statement
disjoint with: EV Observational
disjoint with: EV PK DDI NR
disjoint with: EV PK DDI Observational
disjoint with: EV PK DDI Par Grps
disjoint with: EV PK DDI RCT
disjoint with: EV Population PK
disjoint with: EV Review
disjoint with: EV Statement
disjoint with: EV Traceable Statement
disjoint with: Enzyme
disjoint with: Increased Drug AUC
disjoint with: Increased Drug Level
disjoint with: Induction
disjoint with: Inhibition
disjoint with: Inhibitor
disjoint with: Journal Peer reviewed
disjoint with: Metabolism
disjoint with: Microsomes
disjoint with: Non randomized Tx Assignment
disjoint with: Observation based DI Report Assessment tool
disjoint with: PK DDI
disjoint with: Pharmacodynamic Effect Consequences
disjoint with: Pharmacokinetic Effect Consequences
disjoint with: Pharmacokinetic Process
disjoint with: Public Reporting Database
disjoint with: Randomized Tx Assignment
disjoint with: Recombinant Protein System
disjoint with: Treatment Assignment
disjoint with: Xenobiotic Metabolism
disjoint with: in vitro Protein Source
disjoint with: BiochemicalReaction
disjoint with: Catalysis
disjoint with: Complex
disjoint with: ComplexAssembly
disjoint with: Control
disjoint with: Conversion
disjoint with: Degradation
disjoint with: Dna
disjoint with: DnaRegion
disjoint with: Entity
disjoint with: Gene
disjoint with: GeneticInteraction
disjoint with: Interaction
disjoint with: Modulation
disjoint with: MolecularInteraction
disjoint with: Pathway
disjoint with: PhysicalEntity
disjoint with: Protein
disjoint with: Rna
disjoint with: RnaRegion

Drug Manufacturer
type: Class
subclass of: Thing
disjoint with: Drug Metabolism
disjoint with: EV CT DDI
disjoint with: EV CT DDI Data
disjoint with: EV CT DDI Material
disjoint with: EV CT PK DDI
disjoint with: EV CT PK DDI Data
disjoint with: EV CT PK DDI Material
disjoint with: EV CT PK Genotype
disjoint with: EV CT PK Genotype Data
disjoint with: EV CT PK Genotype Material
disjoint with: EV CT PK Phenotype
disjoint with: EV CT PK Phenotype Data
disjoint with: EV CT PK Phenotype Material
disjoint with: EV CT Pharmacokinetic
disjoint with: EV CT Pharmacokinetic Data
disjoint with: EV CT Pharmacokinetic Material
disjoint with: EV Case Report
disjoint with: EV Case Report ADE
disjoint with: EV Case Report ADE Data
disjoint with: EV Case Report ADE Material
disjoint with: EV Case Report ADE Public Reported
disjoint with: EV Case Report ADE Public Reported Data
disjoint with: EV Case Report ADE Public Reported Material
disjoint with: EV Case Report DI CR
disjoint with: EV Case Report DI CR Data
disjoint with: EV Case Report DI CR Evaluated
disjoint with: EV Case Report DI CR Evaluated Data
disjoint with: EV Case Report DI CR Evaluated Material
disjoint with: EV Case Report DI CR Material
disjoint with: EV Case Report Data
disjoint with: EV Case Report Material
disjoint with: EV Clinical Trial
disjoint with: EV Clinical Trial Data
disjoint with: EV Clinical Trial Material
disjoint with: EV DrugClinicalReview
disjoint with: EV Drug Review
disjoint with: EV EX Met Enz ID
disjoint with: EV EX Met Enz ID CYP450
disjoint with: EV EX Met Enz ID CYP450 Data
disjoint with: EV EX Met Enz ID CYP450 Hum Liver Microsome
disjoint with: EV EX Met Enz ID CYP450 Hum Liver Microsome Antibody
disjoint with: EV EX Met Enz ID CYP450 Hum Liver Microsome Antibody Data
disjoint with: EV EX Met Enz ID CYP450 Hum Liver Microsome Antibody Material
disjoint with: EV EX Met Enz ID CYP450 Hum Liver Microsome Chem
disjoint with: EV EX Met Enz ID CYP450 Hum Liver Microsome Chem Data
disjoint with: EV EX Met Enz ID CYP450 Hum Liver Microsome Chem Material
disjoint with: EV EX Met Enz ID CYP450 Hum Liver Microsome Data
disjoint with: EV EX Met Enz ID CYP450 Hum Liver Microsome Material
disjoint with: EV EX Met Enz ID CYP450 Hum Recom
disjoint with: EV EX Met Enz ID CYP450 Hum Recom Antibody
disjoint with: EV EX Met Enz ID CYP450 Hum Recom Antibody Data
disjoint with: EV EX Met Enz ID CYP450 Hum Recom Antibody Material
disjoint with: EV EX Met Enz ID CYP450 Hum Recom Chem
disjoint with: EV EX Met Enz ID CYP450 Hum Recom Chem Data
disjoint with: EV EX Met Enz ID CYP450 Hum Recom Chem Material
disjoint with: EV EX Met Enz ID CYP450 Hum Recom Data
disjoint with: EV EX Met Enz ID CYP450 Hum Recom Material
disjoint with: EV EX Met Enz ID CYP450 Material
disjoint with: EV EX Met Enz ID Data
disjoint with: EV EX Met Enz ID Material
disjoint with: EV EX Met Enz Inhibit
disjoint with: EV EX Met Enz Inhibit CYP450
disjoint with: EV EX Met Enz Inhibit CYP450 Data
disjoint with: EV EX Met Enz Inhibit CYP450 Human Liver Microsome
disjoint with: EV EX Met Enz Inhibit CYP450 Human Liver Microsome Data
disjoint with: EV EX Met Enz Inhibit CYP450 Human Liver Microsome Material
disjoint with: EV EX Met Enz Inhibit CYP450 Human Recom
disjoint with: EV EX Met Enz Inhibit CYP450 Human Recom Data
disjoint with: EV EX Met Enz Inhibit CYP450 Human Recom Material
disjoint with: EV EX Met Enz Inhibit CYP450 Material
disjoint with: EV EX Met Enz Inhibit Data
disjoint with: EV EX Met Enz Inhibit Material
disjoint with: EV Non Traceable Statement
disjoint with: EV Observational
disjoint with: EV Observational Data
disjoint with: EV Observational Material
disjoint with: EV PK DDI NR
disjoint with: EV PK DDI NR Data

Drug Metabolism
type: Class
subclass of: Pharmacokinetic Process
subclass of: Xenobiotic Metabolism
disjoint with: EV CT DDI
disjoint with: EV CT DDI Data
disjoint with: EV CT DDI Material
disjoint with: EV CT PK DDI
disjoint with: EV CT PK DDI Data
disjoint with: EV CT PK DDI Material
disjoint with: EV CT PK Genotype
disjoint with: EV CT PK Genotype Data
disjoint with: EV CT PK Genotype Material
disjoint with: EV CT PK Phenotype
disjoint with: EV CT PK Phenotype Data
disjoint with: EV CT PK Phenotype Material
disjoint with: EV CT Pharmacokinetic
disjoint with: EV CT Pharmacokinetic Data
disjoint with: EV CT Pharmacokinetic Material
disjoint with: EV Case Report
disjoint with: EV Case Report ADE
disjoint with: EV Case Report ADE Data
disjoint with: EV Case Report ADE Material
disjoint with: EV Case Report ADE Public Reported
disjoint with: EV Case Report ADE Public Reported Data
disjoint with: EV Case Report ADE Public Reported Material
disjoint with: EV Case Report DI CR
disjoint with: EV Case Report DI CR Data
disjoint with: EV Case Report DI CR Evaluated
disjoint with: EV Case Report DI CR Evaluated Data
disjoint with: EV Case Report DI CR Evaluated Material
disjoint with: EV Case Report DI CR Material
disjoint with: EV Case Report Data
disjoint with: EV Case Report Material
disjoint with: EV Clinical Trial
disjoint with: EV Clinical Trial Data
disjoint with: EV Clinical Trial Material
disjoint with: EV DrugClinicalReview
disjoint with: EV Drug Review
disjoint with: EV EX Met Enz ID
disjoint with: EV EX Met Enz ID CYP450
disjoint with: EV EX Met Enz ID CYP450 Data
disjoint with: EV EX Met Enz ID CYP450 Hum Liver Microsome
disjoint with: EV EX Met Enz ID CYP450 Hum Liver Microsome Antibody
disjoint with: EV EX Met Enz ID CYP450 Hum Liver Microsome Antibody Data
disjoint with: EV EX Met Enz ID CYP450 Hum Liver Microsome Antibody Material
disjoint with: EV EX Met Enz ID CYP450 Hum Liver Microsome Chem
disjoint with: EV EX Met Enz ID CYP450 Hum Liver Microsome Chem Data
disjoint with: EV EX Met Enz ID CYP450 Hum Liver Microsome Chem Material
disjoint with: EV EX Met Enz ID CYP450 Hum Liver Microsome Data
disjoint with: EV EX Met Enz ID CYP450 Hum Liver Microsome Material
disjoint with: EV EX Met Enz ID CYP450 Hum Recom
disjoint with: EV EX Met Enz ID CYP450 Hum Recom Antibody
disjoint with: EV EX Met Enz ID CYP450 Hum Recom Antibody Data
disjoint with: EV EX Met Enz ID CYP450 Hum Recom Antibody Material
disjoint with: EV EX Met Enz ID CYP450 Hum Recom Chem
disjoint with: EV EX Met Enz ID CYP450 Hum Recom Chem Data
disjoint with: EV EX Met Enz ID CYP450 Hum Recom Chem Material
disjoint with: EV EX Met Enz ID CYP450 Hum Recom Data
disjoint with: EV EX Met Enz ID CYP450 Hum Recom Material
disjoint with: EV EX Met Enz ID CYP450 Material
disjoint with: EV EX Met Enz ID Data
disjoint with: EV EX Met Enz ID Material
disjoint with: EV EX Met Enz Inhibit
disjoint with: EV EX Met Enz Inhibit CYP450
disjoint with: EV EX Met Enz Inhibit CYP450 Data
disjoint with: EV EX Met Enz Inhibit CYP450 Human Liver Microsome
disjoint with: EV EX Met Enz Inhibit CYP450 Human Liver Microsome Data
disjoint with: EV EX Met Enz Inhibit CYP450 Human Liver Microsome Material
disjoint with: EV EX Met Enz Inhibit CYP450 Human Recom
disjoint with: EV EX Met Enz Inhibit CYP450 Human Recom Data
disjoint with: EV EX Met Enz Inhibit CYP450 Human Recom Material
disjoint with: EV EX Met Enz Inhibit CYP450 Material
disjoint with: EV EX Met Enz Inhibit Data
disjoint with: EV EX Met Enz Inhibit Material
disjoint with: EV Non Traceable Statement
disjoint with: EV Observational
disjoint with: EV Observational Data
disjoint with: EV Observational Material
disjoint with: EV PK DDI NR
disjoint with: EV PK DDI NR Data

EV CT DDI
type: Class
equivalent class: Class
  intersection of: EV Clinical Trial
  intersection of: Restriction
    on property: has focus of inquiry
    some values from: Drug Drug Interaction
  intersection of: Restriction
    on property: investigates drug
    some values from: Drug
  intersection of: Restriction
    on property: has focus of inquiry
    all values from: Drug Drug Interaction
  intersection of: Restriction
    on property: investigates drug
    all values from: Drug
subclass of: EV Clinical Trial
disjoint with: EV CT PK Genotype
disjoint with: EV CT PK Phenotype
disjoint with: EV CT Pharmacokinetic
disjoint with: EV Case Report
disjoint with: EV Case Report ADE
disjoint with: EV Case Report ADE Public Reported
disjoint with: EV Case Report DI CR
disjoint with: EV Case Report DI CR Evaluated
disjoint with: EV DrugClinicalReview
disjoint with: EV Drug Review
disjoint with: EV EX Met Enz ID
disjoint with: EV EX Met Enz ID CYP450
disjoint with: EV EX Met Enz ID CYP450 Hum Liver Microsome
disjoint with: EV EX Met Enz ID CYP450 Hum Liver Microsome Antibody
disjoint with: EV EX Met Enz ID CYP450 Hum Liver Microsome Chem
disjoint with: EV EX Met Enz ID CYP450 Hum Recom
disjoint with: EV EX Met Enz ID CYP450 Hum Recom Antibody
disjoint with: EV EX Met Enz ID CYP450 Hum Recom Chem
disjoint with: EV EX Met Enz Inhibit
disjoint with: EV EX Met Enz Inhibit CYP450
disjoint with: EV EX Met Enz Inhibit CYP450 Human Liver Microsome
disjoint with: EV EX Met Enz Inhibit CYP450 Human Recom
disjoint with: EV Non Traceable Statement
disjoint with: EV Observational
disjoint with: EV PK DDI Observational
disjoint with: EV Population PK
disjoint with: EV Review
disjoint with: EV Statement
disjoint with: EV Traceable Statement
disjoint with: Enzyme
disjoint with: Increased Drug AUC
disjoint with: Increased Drug Level
disjoint with: Induction
disjoint with: Inhibition
disjoint with: Inhibitor
disjoint with: Journal Peer reviewed
disjoint with: Metabolism
disjoint with: Microsomes
disjoint with: Non randomized Tx Assignment
disjoint with: Observation based DI Report Assessment tool
disjoint with: PK DDI
disjoint with: Pharmacodynamic Effect Consequences
disjoint with: Pharmacokinetic Effect Consequences
disjoint with: Pharmacokinetic Process
disjoint with: Public Reporting Database
disjoint with: Randomized Tx Assignment
disjoint with: Recombinant Protein System
disjoint with: Treatment Assignment
disjoint with: Xenobiotic Metabolism
disjoint with: in vitro Protein Source
disjoint with: BiochemicalReaction
disjoint with: Catalysis
disjoint with: Complex
disjoint with: ComplexAssembly
disjoint with: Control
disjoint with: Conversion
disjoint with: Degradation
disjoint with: Dna
disjoint with: DnaRegion
disjoint with: Entity
disjoint with: Gene
disjoint with: GeneticInteraction
disjoint with: Interaction
disjoint with: Modulation
disjoint with: MolecularInteraction
disjoint with: Pathway
disjoint with: PhysicalEntity
disjoint with: Protein
disjoint with: Rna
disjoint with: RnaRegion
disjoint with: SmallMolecule
disjoint with: TemplateReaction
disjoint with: TemplateReactionRegulation
disjoint with: Transport
disjoint with: TransportWithBiochemicalReaction
comment: A study designed to quantify the pharmacokinetic and/or pharmacodynamic effects within study participants of a single drug (the object drug) in the presence of a purported precipitant.
description: A DDI clinical trial

EV CT DDI Data
type: Class
subclass of: EV Clinical Trial Data
disjoint with: EV CT PK Genotype Data
disjoint with: EV CT PK Phenotype Data
disjoint with: EV CT Pharmacokinetic Data
disjoint with: EV Case Report ADE Data
disjoint with: EV Case Report ADE Public Reported Data
disjoint with: EV Case Report DI CR Data
disjoint with: EV Case Report DI CR Evaluated Data
disjoint with: EV Case Report Data
disjoint with: EV EX Met Enz ID CYP450 Data
disjoint with: EV EX Met Enz ID CYP450 Hum Liver Microsome Antibody Data
disjoint with: EV EX Met Enz ID CYP450 Hum Liver Microsome Chem Data
disjoint with: EV EX Met Enz ID CYP450 Hum Liver Microsome Data
disjoint with: EV EX Met Enz ID CYP450 Hum Recom Antibody Data
disjoint with: EV EX Met Enz ID CYP450 Hum Recom Chem Data
disjoint with: EV EX Met Enz ID CYP450 Hum Recom Data
disjoint with: EV EX Met Enz ID Data
disjoint with: EV EX Met Enz Inhibit CYP450 Data
disjoint with: EV EX Met Enz Inhibit CYP450 Human Liver Microsome Data
disjoint with: EV EX Met Enz Inhibit CYP450 Human Recom Data
disjoint with: EV EX Met Enz Inhibit Data
disjoint with: EV Observational Data
disjoint with: EV PK DDI Observational Data
disjoint with: EV Population PK Data
disjoint with: Enzyme
disjoint with: Increased Drug AUC
disjoint with: Increased Drug Level
disjoint with: Induction
disjoint with: Inhibition
disjoint with: Inhibitor
disjoint with: Journal Peer reviewed
disjoint with: Metabolism
disjoint with: Microsomes
disjoint with: Non randomized Tx Assignment
disjoint with: Observation based DI Report Assessment tool
disjoint with: PK DDI
disjoint with: Pharmacodynamic Effect Consequences
disjoint with: Pharmacokinetic Effect Consequences
disjoint with: Pharmacokinetic Process
disjoint with: Public Reporting Database
disjoint with: Randomized Tx Assignment
disjoint with: Recombinant Protein System
disjoint with: Treatment Assignment
disjoint with: Xenobiotic Metabolism
disjoint with: in vitro Protein Source
disjoint with: BiochemicalReaction
disjoint with: Catalysis
disjoint with: Complex
disjoint with: ComplexAssembly
disjoint with: Control
disjoint with: Conversion
disjoint with: Degradation
disjoint with: Dna
disjoint with: DnaRegion
disjoint with: Entity
disjoint with: Gene
disjoint with: GeneticInteraction
disjoint with: Interaction
disjoint with: Modulation
disjoint with: MolecularInteraction
disjoint with: Pathway
disjoint with: PhysicalEntity
disjoint with: Protein
disjoint with: Rna
disjoint with: RnaRegion
disjoint with: SmallMolecule
disjoint with: TemplateReaction
disjoint with: TemplateReactionRegulation
disjoint with: Transport
disjoint with: TransportWithBiochemicalReaction
description: Data from a study designed to quantify the pharmacokinetic and/or pharmacodynamic effects within study participants of a single drug (the object drug) in the presence of a purported precipitant.

EV CT DDI Material
type: Class
subclass of: EV Clinical Trial Material
disjoint with: EV CT PK Genotype Material
disjoint with: EV CT PK Phenotype Material
disjoint with: EV CT Pharmacokinetic Material
disjoint with: EV Case Report ADE Material
disjoint with: EV Case Report ADE Public Reported Material
disjoint with: EV Case Report DI CR Evaluated Material
disjoint with: EV Case Report DI CR Material
disjoint with: EV Case Report Material
disjoint with: EV EX Met Enz ID CYP450 Hum Liver Microsome Antibody Material
disjoint with: EV EX Met Enz ID CYP450 Hum Liver Microsome Chem Material
disjoint with: EV EX Met Enz ID CYP450 Hum Liver Microsome Material
disjoint with: EV EX Met Enz ID CYP450 Hum Recom Antibody Material
disjoint with: EV EX Met Enz ID CYP450 Hum Recom Chem Material
disjoint with: EV EX Met Enz ID CYP450 Hum Recom Material
disjoint with: EV EX Met Enz ID CYP450 Material
disjoint with: EV EX Met Enz ID Material
disjoint with: EV EX Met Enz Inhibit CYP450 Human Liver Microsome Material
disjoint with: EV EX Met Enz Inhibit CYP450 Human Recom Material
disjoint with: EV EX Met Enz Inhibit CYP450 Material
disjoint with: EV EX Met Enz Inhibit Material
disjoint with: EV Observational Material
disjoint with: EV PK DDI Observational Material
disjoint with: EV Population PK Material
disjoint with: Enzyme
disjoint with: Increased Drug AUC
disjoint with: Increased Drug Level
disjoint with: Induction
disjoint with: Inhibition
disjoint with: Inhibitor
disjoint with: Journal Peer reviewed
disjoint with: Metabolism
disjoint with: Microsomes
disjoint with: Non randomized Tx Assignment
disjoint with: Observation based DI Report Assessment tool
disjoint with: PK DDI
disjoint with: Pharmacodynamic Effect Consequences
disjoint with: Pharmacokinetic Effect Consequences
disjoint with: Pharmacokinetic Process
disjoint with: Public Reporting Database
disjoint with: Randomized Tx Assignment
disjoint with: Recombinant Protein System
disjoint with: Treatment Assignment
disjoint with: Xenobiotic Metabolism
disjoint with: in vitro Protein Source
disjoint with: BiochemicalReaction
disjoint with: Catalysis
disjoint with: Complex
disjoint with: ComplexAssembly
disjoint with: Control
disjoint with: Conversion
disjoint with: Degradation
disjoint with: Dna
disjoint with: DnaRegion
disjoint with: Entity
disjoint with: Gene
disjoint with: GeneticInteraction
disjoint with: Interaction
disjoint with: Modulation
disjoint with: MolecularInteraction
disjoint with: Pathway
disjoint with: PhysicalEntity
disjoint with: Protein
disjoint with: Rna
disjoint with: RnaRegion
disjoint with: SmallMolecule
disjoint with: TemplateReaction
disjoint with: TemplateReactionRegulation
disjoint with: Transport
disjoint with: TransportWithBiochemicalReaction
description: Material from a study designed to quantify the pharmacokinetic and/or pharmacodynamic effects within study participants of a single drug (the object drug) in the presence of a purported precipitant.

EV CT PK DDI
type: Class
equivalent class: Class
  intersection of: EV CT DDI
  intersection of: Restriction
    on property: has focus of inquiry
    some values from: PK DDI
  intersection of: Restriction
    on property: has focus of inquiry
    all values from: PK DDI
subclass of: EV CT DDI
disjoint with: EV CT PK Genotype
disjoint with: EV CT PK Phenotype
disjoint with: EV CT Pharmacokinetic
disjoint with: EV Case Report
disjoint with: EV Case Report ADE
disjoint with: EV Case Report ADE Public Reported
disjoint with: EV Case Report DI CR
disjoint with: EV Case Report DI CR Evaluated
disjoint with: EV DrugClinicalReview
disjoint with: EV Drug Review
disjoint with: EV EX Met Enz ID
disjoint with: EV EX Met Enz ID CYP450
disjoint with: EV EX Met Enz ID CYP450 Hum Liver Microsome
disjoint with: EV EX Met Enz ID CYP450 Hum Liver Microsome Antibody
disjoint with: EV EX Met Enz ID CYP450 Hum Liver Microsome Chem
disjoint with: EV EX Met Enz ID CYP450 Hum Recom
disjoint with: EV EX Met Enz ID CYP450 Hum Recom Antibody
disjoint with: EV EX Met Enz ID CYP450 Hum Recom Chem
disjoint with: EV EX Met Enz Inhibit
disjoint with: EV EX Met Enz Inhibit CYP450
disjoint with: EV EX Met Enz Inhibit CYP450 Human Liver Microsome
disjoint with: EV EX Met Enz Inhibit CYP450 Human Recom
disjoint with: EV Non Traceable Statement
disjoint with: EV Observational
disjoint with: EV PK DDI Observational
disjoint with: EV Population PK
disjoint with: EV Review
disjoint with: EV Statement
disjoint with: EV Traceable Statement
disjoint with: Enzyme
disjoint with: Increased Drug AUC
disjoint with: Increased Drug Level
disjoint with: Induction
disjoint with: Inhibition
disjoint with: Inhibitor
disjoint with: Journal Peer reviewed
disjoint with: Metabolism
disjoint with: Microsomes
disjoint with: Non randomized Tx Assignment
disjoint with: Observation based DI Report Assessment tool
disjoint with: PK DDI
disjoint with: Pharmacodynamic Effect Consequences
disjoint with: Pharmacokinetic Effect Consequences
disjoint with: Pharmacokinetic Process
disjoint with: Public Reporting Database
disjoint with: Randomized Tx Assignment
disjoint with: Recombinant Protein System
disjoint with: Treatment Assignment
disjoint with: Xenobiotic Metabolism
disjoint with: in vitro Protein Source
disjoint with: BiochemicalReaction
disjoint with: Catalysis
disjoint with: Complex
disjoint with: ComplexAssembly
disjoint with: Control
disjoint with: Conversion
disjoint with: Degradation
disjoint with: Dna
disjoint with: DnaRegion
disjoint with: Entity
disjoint with: Gene
disjoint with: GeneticInteraction
disjoint with: Interaction
disjoint with: Modulation
disjoint with: MolecularInteraction
disjoint with: Pathway
disjoint with: PhysicalEntity
disjoint with: Protein
disjoint with: Rna
disjoint with: RnaRegion
disjoint with: SmallMolecule
disjoint with: TemplateReaction
disjoint with: TemplateReactionRegulation
disjoint with: Transport
disjoint with: TransportWithBiochemicalReaction
description: A study designed to quantify the pharmacokinetic effects within study participants of a single drug in the presence of a purported precipitant.

EV CT PK DDI Data
type: Class
subclass of: EV CT DDI Data
disjoint with: EV CT PK Genotype Data
disjoint with: EV CT PK Phenotype Data
disjoint with: EV CT Pharmacokinetic Data
disjoint with: EV Case Report ADE Data
disjoint with: EV Case Report ADE Public Reported Data
disjoint with: EV Case Report DI CR Data
disjoint with: EV Case Report DI CR Evaluated Data
disjoint with: EV Case Report Data
disjoint with: EV EX Met Enz ID CYP450 Data
disjoint with: EV EX Met Enz ID CYP450 Hum Liver Microsome Antibody Data
disjoint with: EV EX Met Enz ID CYP450 Hum Liver Microsome Chem Data
disjoint with: EV EX Met Enz ID CYP450 Hum Liver Microsome Data
disjoint with: EV EX Met Enz ID CYP450 Hum Recom Antibody Data
disjoint with: EV EX Met Enz ID CYP450 Hum Recom Chem Data
disjoint with: EV EX Met Enz ID CYP450 Hum Recom Data
disjoint with: EV EX Met Enz ID Data
disjoint with: EV EX Met Enz Inhibit CYP450 Data
disjoint with: EV EX Met Enz Inhibit CYP450 Human Liver Microsome Data
disjoint with: EV EX Met Enz Inhibit CYP450 Human Recom Data
disjoint with: EV EX Met Enz Inhibit Data
disjoint with: EV Observational Data
disjoint with: EV PK DDI Observational Data
disjoint with: EV Population PK Data
disjoint with: Enzyme
disjoint with: Increased Drug AUC
disjoint with: Increased Drug Level
disjoint with: Induction
disjoint with: Inhibition
disjoint with: Inhibitor
disjoint with: Journal Peer reviewed
disjoint with: Metabolism
disjoint with: Microsomes
disjoint with: Non randomized Tx Assignment
disjoint with: Observation based DI Report Assessment tool
disjoint with: PK DDI
disjoint with: Pharmacodynamic Effect Consequences
disjoint with: Pharmacokinetic Effect Consequences
disjoint with: Pharmacokinetic Process
disjoint with: Public Reporting Database
disjoint with: Randomized Tx Assignment
disjoint with: Recombinant Protein System
disjoint with: Treatment Assignment
disjoint with: Xenobiotic Metabolism
disjoint with: in vitro Protein Source
disjoint with: BiochemicalReaction
disjoint with: Catalysis
disjoint with: Complex
disjoint with: ComplexAssembly
disjoint with: Control
disjoint with: Conversion
disjoint with: Degradation
disjoint with: Dna
disjoint with: DnaRegion
disjoint with: Entity
disjoint with: Gene
disjoint with: GeneticInteraction
disjoint with: Interaction
disjoint with: Modulation
disjoint with: MolecularInteraction
disjoint with: Pathway
disjoint with: PhysicalEntity
disjoint with: Protein
disjoint with: Rna
disjoint with: RnaRegion
disjoint with: SmallMolecule
disjoint with: TemplateReaction
disjoint with: TemplateReactionRegulation
disjoint with: Transport
disjoint with: TransportWithBiochemicalReaction
description: Data from a study designed to quantify the pharmacokinetic effects within study participants of a single drug in the presence of a purported precipitant.

EV CT PK DDI Material
type: Class
subclass of: EV CT DDI Material
disjoint with: EV CT PK Genotype Material
disjoint with: EV CT PK Phenotype Material
disjoint with: EV CT Pharmacokinetic Material
disjoint with: EV Case Report ADE Material
disjoint with: EV Case Report ADE Public Reported Material
disjoint with: EV Case Report DI CR Evaluated Material
disjoint with: EV Case Report DI CR Material
disjoint with: EV Case Report Material
disjoint with: EV EX Met Enz ID CYP450 Hum Liver Microsome Antibody Material
disjoint with: EV EX Met Enz ID CYP450 Hum Liver Microsome Chem Material
disjoint with: EV EX Met Enz ID CYP450 Hum Liver Microsome Material
disjoint with: EV EX Met Enz ID CYP450 Hum Recom Antibody Material
disjoint with: EV EX Met Enz ID CYP450 Hum Recom Chem Material
disjoint with: EV EX Met Enz ID CYP450 Hum Recom Material
disjoint with: EV EX Met Enz ID CYP450 Material
disjoint with: EV EX Met Enz ID Material
disjoint with: EV EX Met Enz Inhibit CYP450 Human Liver Microsome Material
disjoint with: EV EX Met Enz Inhibit CYP450 Human Recom Material
disjoint with: EV EX Met Enz Inhibit CYP450 Material
disjoint with: EV EX Met Enz Inhibit Material
disjoint with: EV Observational Material
disjoint with: EV PK DDI Observational Material
disjoint with: EV Population PK Material
disjoint with: Enzyme
disjoint with: Increased Drug AUC
disjoint with: Increased Drug Level
disjoint with: Induction
disjoint with: Inhibition
disjoint with: Inhibitor
disjoint with: Journal Peer reviewed
disjoint with: Metabolism
disjoint with: Microsomes
disjoint with: Non randomized Tx Assignment
disjoint with: Observation based DI Report Assessment tool
disjoint with: PK DDI
disjoint with: Pharmacodynamic Effect Consequences
disjoint with: Pharmacokinetic Effect Consequences
disjoint with: Pharmacokinetic Process
disjoint with: Public Reporting Database
disjoint with: Randomized Tx Assignment
disjoint with: Recombinant Protein System
disjoint with: Treatment Assignment
disjoint with: Xenobiotic Metabolism
disjoint with: in vitro Protein Source
disjoint with: BiochemicalReaction
disjoint with: Catalysis
disjoint with: Complex
disjoint with: ComplexAssembly
disjoint with: Control
disjoint with: Conversion
disjoint with: Degradation
disjoint with: Dna
disjoint with: DnaRegion
disjoint with: Entity
disjoint with: Gene
disjoint with: GeneticInteraction
disjoint with: Interaction
disjoint with: Modulation
disjoint with: MolecularInteraction
disjoint with: Pathway
disjoint with: PhysicalEntity
disjoint with: Protein
disjoint with: Rna
disjoint with: RnaRegion
disjoint with: SmallMolecule
disjoint with: TemplateReaction
disjoint with: TemplateReactionRegulation
disjoint with: Transport
disjoint with: TransportWithBiochemicalReaction
description: Material from a study designed to quantify the pharmacokinetic effects within study participants of a single drug in the presence of a purported precipitant.

EV CT PK Genotype
type: Class
subclass of: EV CT Pharmacokinetic
disjoint with: EV Case Report
disjoint with: EV Case Report ADE
disjoint with: EV Case Report ADE Public Reported
disjoint with: EV Case Report DI CR
disjoint with: EV Case Report DI CR Evaluated
disjoint with: EV DrugClinicalReview
disjoint with: EV Drug Review
disjoint with: EV EX Met Enz ID
disjoint with: EV EX Met Enz ID CYP450
disjoint with: EV EX Met Enz ID CYP450 Hum Liver Microsome
disjoint with: EV EX Met Enz ID CYP450 Hum Liver Microsome Antibody
disjoint with: EV EX Met Enz ID CYP450 Hum Liver Microsome Chem
disjoint with: EV EX Met Enz ID CYP450 Hum Recom
disjoint with: EV EX Met Enz ID CYP450 Hum Recom Antibody
disjoint with: EV EX Met Enz ID CYP450 Hum Recom Chem
disjoint with: EV EX Met Enz Inhibit
disjoint with: EV EX Met Enz Inhibit CYP450
disjoint with: EV EX Met Enz Inhibit CYP450 Human Liver Microsome
disjoint with: EV EX Met Enz Inhibit CYP450 Human Recom
disjoint with: EV Non Traceable Statement
disjoint with: EV Observational
disjoint with: EV PK DDI NR
disjoint with: EV PK DDI Observational
disjoint with: EV PK DDI Par Grps
disjoint with: EV PK DDI RCT
disjoint with: EV Population PK
disjoint with: EV Review
disjoint with: EV Statement
disjoint with: EV Traceable Statement
disjoint with: Enzyme
disjoint with: Increased Drug AUC
disjoint with: Increased Drug Level
disjoint with: Induction
disjoint with: Inhibition
disjoint with: Inhibitor
disjoint with: Journal Peer reviewed
disjoint with: Metabolism
disjoint with: Microsomes
disjoint with: Non randomized Tx Assignment
disjoint with: Observation based DI Report Assessment tool
disjoint with: PK DDI
disjoint with: Pharmacodynamic Effect Consequences
disjoint with: Pharmacokinetic Effect Consequences
disjoint with: Pharmacokinetic Process
disjoint with: Public Reporting Database
disjoint with: Randomized Tx Assignment
disjoint with: Recombinant Protein System
disjoint with: Treatment Assignment
disjoint with: Xenobiotic Metabolism
disjoint with: in vitro Protein Source
disjoint with: BiochemicalReaction
disjoint with: Catalysis
disjoint with: Complex
disjoint with: ComplexAssembly
disjoint with: Control
disjoint with: Conversion
disjoint with: Degradation
disjoint with: Dna
disjoint with: DnaRegion
disjoint with: Entity
disjoint with: Gene
disjoint with: GeneticInteraction
disjoint with: Interaction
disjoint with: Modulation
disjoint with: MolecularInteraction
disjoint with: Pathway
disjoint with: PhysicalEntity
disjoint with: Protein
disjoint with: Rna
disjoint with: RnaRegion
disjoint with: SmallMolecule
disjoint with: TemplateReaction
disjoint with: TemplateReactionRegulation
disjoint with: Transport
disjoint with: TransportWithBiochemicalReaction
description: A genotyped pharmacokinetic clinical trial
comment: A drug pharmacokinetics study whose population consists of at least two groups known to posses distinct forms of some drug-metabolizing enzyme

EV CT PK Genotype Data
type: Class
subclass of: EV CT Pharmacokinetic Data
disjoint with: EV Case Report ADE Data
disjoint with: EV Case Report ADE Public Reported Data
disjoint with: EV Case Report DI CR Data
disjoint with: EV Case Report DI CR Evaluated Data
disjoint with: EV Case Report Data
disjoint with: EV EX Met Enz ID CYP450 Data
disjoint with: EV EX Met Enz ID CYP450 Hum Liver Microsome Antibody Data
disjoint with: EV EX Met Enz ID CYP450 Hum Liver Microsome Chem Data
disjoint with: EV EX Met Enz ID CYP450 Hum Liver Microsome Data
disjoint with: EV EX Met Enz ID CYP450 Hum Recom Antibody Data
disjoint with: EV EX Met Enz ID CYP450 Hum Recom Chem Data
disjoint with: EV EX Met Enz ID CYP450 Hum Recom Data
disjoint with: EV EX Met Enz ID Data
disjoint with: EV EX Met Enz Inhibit CYP450 Data
disjoint with: EV EX Met Enz Inhibit CYP450 Human Liver Microsome Data
disjoint with: EV EX Met Enz Inhibit CYP450 Human Recom Data
disjoint with: EV EX Met Enz Inhibit Data
disjoint with: EV Observational Data
disjoint with: EV PK DDI NR Data
disjoint with: EV PK DDI Observational Data
disjoint with: EV PK DDI Par Grps Data
disjoint with: EV PK DDI RCT Data
disjoint with: EV Population PK Data
disjoint with: Enzyme
disjoint with: Increased Drug AUC
disjoint with: Increased Drug Level
disjoint with: Induction
disjoint with: Inhibition
disjoint with: Inhibitor
disjoint with: Journal Peer reviewed
disjoint with: Metabolism
disjoint with: Microsomes
disjoint with: Non randomized Tx Assignment
disjoint with: Observation based DI Report Assessment tool
disjoint with: PK DDI
disjoint with: Pharmacodynamic Effect Consequences
disjoint with: Pharmacokinetic Effect Consequences
disjoint with: Pharmacokinetic Process
disjoint with: Public Reporting Database
disjoint with: Randomized Tx Assignment
disjoint with: Recombinant Protein System
disjoint with: Treatment Assignment
disjoint with: Xenobiotic Metabolism
disjoint with: in vitro Protein Source
disjoint with: BiochemicalReaction
disjoint with: Catalysis
disjoint with: Complex
disjoint with: ComplexAssembly
disjoint with: Control
disjoint with: Conversion
disjoint with: Degradation
disjoint with: Dna
disjoint with: DnaRegion
disjoint with: Entity
disjoint with: Gene
disjoint with: GeneticInteraction
disjoint with: Interaction
disjoint with: Modulation
disjoint with: MolecularInteraction
disjoint with: Pathway
disjoint with: PhysicalEntity
disjoint with: Protein
disjoint with: Rna
disjoint with: RnaRegion
disjoint with: SmallMolecule
disjoint with: TemplateReaction
disjoint with: TemplateReactionRegulation
disjoint with: Transport
disjoint with: TransportWithBiochemicalReaction
description: Data from a drug pharmacokinetics study whose population consists of at least two groups known to posses distinct forms of some drug-metabolizing enzyme

EV CT PK Genotype Material
type: Class
subclass of: EV CT Pharmacokinetic Material
disjoint with: EV Case Report ADE Material
disjoint with: EV Case Report ADE Public Reported Material
disjoint with: EV Case Report DI CR Evaluated Material
disjoint with: EV Case Report DI CR Material
disjoint with: EV Case Report Material
disjoint with: EV EX Met Enz ID CYP450 Hum Liver Microsome Antibody Material
disjoint with: EV EX Met Enz ID CYP450 Hum Liver Microsome Chem Material
disjoint with: EV EX Met Enz ID CYP450 Hum Liver Microsome Material
disjoint with: EV EX Met Enz ID CYP450 Hum Recom Antibody Material
disjoint with: EV EX Met Enz ID CYP450 Hum Recom Chem Material
disjoint with: EV EX Met Enz ID CYP450 Hum Recom Material
disjoint with: EV EX Met Enz ID CYP450 Material
disjoint with: EV EX Met Enz ID Material
disjoint with: EV EX Met Enz Inhibit CYP450 Human Liver Microsome Material
disjoint with: EV EX Met Enz Inhibit CYP450 Human Recom Material
disjoint with: EV EX Met Enz Inhibit CYP450 Material
disjoint with: EV EX Met Enz Inhibit Material
disjoint with: EV Observational Material
disjoint with: EV PK DDI NR Material
disjoint with: EV PK DDI Observational Material
disjoint with: EV PK DDI Par Grps Material
disjoint with: EV PK DDI RCT Material
disjoint with: EV Population PK Material
disjoint with: Enzyme
disjoint with: Increased Drug AUC
disjoint with: Increased Drug Level
disjoint with: Induction
disjoint with: Inhibition
disjoint with: Inhibitor
disjoint with: Journal Peer reviewed
disjoint with: Metabolism
disjoint with: Microsomes
disjoint with: Non randomized Tx Assignment
disjoint with: Observation based DI Report Assessment tool
disjoint with: PK DDI
disjoint with: Pharmacodynamic Effect Consequences
disjoint with: Pharmacokinetic Effect Consequences
disjoint with: Pharmacokinetic Process
disjoint with: Public Reporting Database
disjoint with: Randomized Tx Assignment
disjoint with: Recombinant Protein System
disjoint with: Treatment Assignment
disjoint with: Xenobiotic Metabolism
disjoint with: in vitro Protein Source
disjoint with: BiochemicalReaction
disjoint with: Catalysis
disjoint with: Complex
disjoint with: ComplexAssembly
disjoint with: Control
disjoint with: Conversion
disjoint with: Degradation
disjoint with: Dna
disjoint with: DnaRegion
disjoint with: Entity
disjoint with: Gene
disjoint with: GeneticInteraction
disjoint with: Interaction
disjoint with: Modulation
disjoint with: MolecularInteraction
disjoint with: Pathway
disjoint with: PhysicalEntity
disjoint with: Protein
disjoint with: Rna
disjoint with: RnaRegion
disjoint with: SmallMolecule
disjoint with: TemplateReaction
disjoint with: TemplateReactionRegulation
disjoint with: Transport
disjoint with: TransportWithBiochemicalReaction
description: Material from a drug pharmacokinetics study whose population consists of at least two groups known to posses distinct forms of some drug-metabolizing enzyme

EV CT PK Phenotype
type: Class
subclass of: EV CT Pharmacokinetic
disjoint with: EV Case Report
disjoint with: EV Case Report ADE
disjoint with: EV Case Report ADE Public Reported
disjoint with: EV Case Report DI CR
disjoint with: EV Case Report DI CR Evaluated
disjoint with: EV DrugClinicalReview
disjoint with: EV Drug Review
disjoint with: EV EX Met Enz ID
disjoint with: EV EX Met Enz ID CYP450
disjoint with: EV EX Met Enz ID CYP450 Hum Liver Microsome
disjoint with: EV EX Met Enz ID CYP450 Hum Liver Microsome Antibody
disjoint with: EV EX Met Enz ID CYP450 Hum Liver Microsome Chem
disjoint with: EV EX Met Enz ID CYP450 Hum Recom
disjoint with: EV EX Met Enz ID CYP450 Hum Recom Antibody
disjoint with: EV EX Met Enz ID CYP450 Hum Recom Chem
disjoint with: EV EX Met Enz Inhibit
disjoint with: EV EX Met Enz Inhibit CYP450
disjoint with: EV EX Met Enz Inhibit CYP450 Human Liver Microsome
disjoint with: EV EX Met Enz Inhibit CYP450 Human Recom
disjoint with: EV Non Traceable Statement
disjoint with: EV Observational
disjoint with: EV PK DDI NR
disjoint with: EV PK DDI Observational
disjoint with: EV PK DDI Par Grps
disjoint with: EV PK DDI RCT
disjoint with: EV Population PK
disjoint with: EV Review
disjoint with: EV Statement
disjoint with: EV Traceable Statement
disjoint with: Enzyme
disjoint with: Increased Drug AUC
disjoint with: Increased Drug Level
disjoint with: Induction
disjoint with: Inhibition
disjoint with: Inhibitor
disjoint with: Journal Peer reviewed
disjoint with: Metabolism
disjoint with: Microsomes
disjoint with: Non randomized Tx Assignment
disjoint with: Observation based DI Report Assessment tool
disjoint with: PK DDI
disjoint with: Pharmacodynamic Effect Consequences
disjoint with: Pharmacokinetic Effect Consequences
disjoint with: Pharmacokinetic Process
disjoint with: Public Reporting Database
disjoint with: Randomized Tx Assignment
disjoint with: Recombinant Protein System
disjoint with: Treatment Assignment
disjoint with: Xenobiotic Metabolism
disjoint with: in vitro Protein Source
disjoint with: BiochemicalReaction
disjoint with: Catalysis
disjoint with: Complex
disjoint with: ComplexAssembly
disjoint with: Control
disjoint with: Conversion
disjoint with: Degradation
disjoint with: Dna
disjoint with: DnaRegion
disjoint with: Entity
disjoint with: Gene
disjoint with: GeneticInteraction
disjoint with: Interaction
disjoint with: Modulation
disjoint with: MolecularInteraction
disjoint with: Pathway
disjoint with: PhysicalEntity
disjoint with: Protein
disjoint with: Rna
disjoint with: RnaRegion
disjoint with: SmallMolecule
disjoint with: TemplateReaction
disjoint with: TemplateReactionRegulation
disjoint with: Transport
disjoint with: TransportWithBiochemicalReaction
description: A phenotyped pharmacokinetic clinical trial
comment: A drug pharmacokinetics study whose population consists of at least two groups known to posses distinct drug metabolizing phenotypes

EV CT PK Phenotype Data
type: Class
subclass of: EV CT Pharmacokinetic Data
disjoint with: EV Case Report ADE Data
disjoint with: EV Case Report ADE Public Reported Data
disjoint with: EV Case Report DI CR Data
disjoint with: EV Case Report DI CR Evaluated Data
disjoint with: EV Case Report Data
disjoint with: EV EX Met Enz ID CYP450 Data
disjoint with: EV EX Met Enz ID CYP450 Hum Liver Microsome Antibody Data
disjoint with: EV EX Met Enz ID CYP450 Hum Liver Microsome Chem Data
disjoint with: EV EX Met Enz ID CYP450 Hum Liver Microsome Data
disjoint with: EV EX Met Enz ID CYP450 Hum Recom Antibody Data
disjoint with: EV EX Met Enz ID CYP450 Hum Recom Chem Data
disjoint with: EV EX Met Enz ID CYP450 Hum Recom Data
disjoint with: EV EX Met Enz ID Data
disjoint with: EV EX Met Enz Inhibit CYP450 Data
disjoint with: EV EX Met Enz Inhibit CYP450 Human Liver Microsome Data
disjoint with: EV EX Met Enz Inhibit CYP450 Human Recom Data
disjoint with: EV EX Met Enz Inhibit Data
disjoint with: EV Observational Data
disjoint with: EV PK DDI NR Data
disjoint with: EV PK DDI Observational Data
disjoint with: EV PK DDI Par Grps Data
disjoint with: EV PK DDI RCT Data
disjoint with: EV Population PK Data
disjoint with: Enzyme
disjoint with: Increased Drug AUC
disjoint with: Increased Drug Level
disjoint with: Induction
disjoint with: Inhibition
disjoint with: Inhibitor
disjoint with: Journal Peer reviewed
disjoint with: Metabolism
disjoint with: Microsomes
disjoint with: Non randomized Tx Assignment
disjoint with: Observation based DI Report Assessment tool
disjoint with: PK DDI
disjoint with: Pharmacodynamic Effect Consequences
disjoint with: Pharmacokinetic Effect Consequences
disjoint with: Pharmacokinetic Process
disjoint with: Public Reporting Database
disjoint with: Randomized Tx Assignment
disjoint with: Recombinant Protein System
disjoint with: Treatment Assignment
disjoint with: Xenobiotic Metabolism
disjoint with: in vitro Protein Source
disjoint with: BiochemicalReaction
disjoint with: Catalysis
disjoint with: Complex
disjoint with: ComplexAssembly
disjoint with: Control
disjoint with: Conversion
disjoint with: Degradation
disjoint with: Dna
disjoint with: DnaRegion
disjoint with: Entity
disjoint with: Gene
disjoint with: GeneticInteraction
disjoint with: Interaction
disjoint with: Modulation
disjoint with: MolecularInteraction
disjoint with: Pathway
disjoint with: PhysicalEntity
disjoint with: Protein
disjoint with: Rna
disjoint with: RnaRegion
disjoint with: SmallMolecule
disjoint with: TemplateReaction
disjoint with: TemplateReactionRegulation
disjoint with: Transport
disjoint with: TransportWithBiochemicalReaction
description: Data from a drug pharmacokinetics study whose population consists of at least two groups known to posses distinct drug metabolizing phenotypes

EV CT PK Phenotype Material
type: Class
subclass of: EV CT Pharmacokinetic Material
disjoint with: EV Case Report ADE Material
disjoint with: EV Case Report ADE Public Reported Material
disjoint with: EV Case Report DI CR Evaluated Material
disjoint with: EV Case Report DI CR Material
disjoint with: EV Case Report Material
disjoint with: EV EX Met Enz ID CYP450 Hum Liver Microsome Antibody Material
disjoint with: EV EX Met Enz ID CYP450 Hum Liver Microsome Chem Material
disjoint with: EV EX Met Enz ID CYP450 Hum Liver Microsome Material
disjoint with: EV EX Met Enz ID CYP450 Hum Recom Antibody Material
disjoint with: EV EX Met Enz ID CYP450 Hum Recom Chem Material
disjoint with: EV EX Met Enz ID CYP450 Hum Recom Material
disjoint with: EV EX Met Enz ID CYP450 Material
disjoint with: EV EX Met Enz ID Material
disjoint with: EV EX Met Enz Inhibit CYP450 Human Liver Microsome Material
disjoint with: EV EX Met Enz Inhibit CYP450 Human Recom Material
disjoint with: EV EX Met Enz Inhibit CYP450 Material
disjoint with: EV EX Met Enz Inhibit Material
disjoint with: EV Observational Material
disjoint with: EV PK DDI NR Material
disjoint with: EV PK DDI Observational Material
disjoint with: EV PK DDI Par Grps Material
disjoint with: EV PK DDI RCT Material
disjoint with: EV Population PK Material
disjoint with: Enzyme
disjoint with: Increased Drug AUC
disjoint with: Increased Drug Level
disjoint with: Induction
disjoint with: Inhibition
disjoint with: Inhibitor
disjoint with: Journal Peer reviewed
disjoint with: Metabolism
disjoint with: Microsomes
disjoint with: Non randomized Tx Assignment
disjoint with: Observation based DI Report Assessment tool
disjoint with: PK DDI
disjoint with: Pharmacodynamic Effect Consequences
disjoint with: Pharmacokinetic Effect Consequences
disjoint with: Pharmacokinetic Process
disjoint with: Public Reporting Database
disjoint with: Randomized Tx Assignment
disjoint with: Recombinant Protein System
disjoint with: Treatment Assignment
disjoint with: Xenobiotic Metabolism
disjoint with: in vitro Protein Source
disjoint with: BiochemicalReaction
disjoint with: Catalysis
disjoint with: Complex
disjoint with: ComplexAssembly
disjoint with: Control
disjoint with: Conversion
disjoint with: Degradation
disjoint with: Dna
disjoint with: DnaRegion
disjoint with: Entity
disjoint with: Gene
disjoint with: GeneticInteraction
disjoint with: Interaction
disjoint with: Modulation
disjoint with: MolecularInteraction
disjoint with: Pathway
disjoint with: PhysicalEntity
disjoint with: Protein
disjoint with: Rna
disjoint with: RnaRegion
disjoint with: SmallMolecule
disjoint with: TemplateReaction
disjoint with: TemplateReactionRegulation
disjoint with: Transport
disjoint with: TransportWithBiochemicalReaction
description: Material from a drug pharmacokinetics study whose population consists of at least two groups known to posses distinct drug metabolizing phenotypes

EV CT Pharmacokinetic
type: Class
equivalent class: Class
  intersection of: EV Clinical Trial
  intersection of: Restriction
    on property: has focus of inquiry
    some values from: Pharmacokinetic Process
  intersection of: Restriction
    on property: investigates drug
    some values from: Drug
  intersection of: Restriction
    on property: has focus of inquiry
    all values from: Pharmacokinetic Process
  intersection of: Restriction
    on property: investigates drug
    all values from: Drug
subclass of: EV Clinical Trial
disjoint with: EV Case Report
disjoint with: EV Case Report ADE
disjoint with: EV Case Report ADE Public Reported
disjoint with: EV Case Report DI CR
disjoint with: EV Case Report DI CR Evaluated
disjoint with: EV DrugClinicalReview
disjoint with: EV Drug Review
disjoint with: EV EX Met Enz ID
disjoint with: EV EX Met Enz ID CYP450
disjoint with: EV EX Met Enz ID CYP450 Hum Liver Microsome
disjoint with: EV EX Met Enz ID CYP450 Hum Liver Microsome Antibody
disjoint with: EV EX Met Enz ID CYP450 Hum Liver Microsome Chem
disjoint with: EV EX Met Enz ID CYP450 Hum Recom
disjoint with: EV EX Met Enz ID CYP450 Hum Recom Antibody
disjoint with: EV EX Met Enz ID CYP450 Hum Recom Chem
disjoint with: EV EX Met Enz Inhibit
disjoint with: EV EX Met Enz Inhibit CYP450
disjoint with: EV EX Met Enz Inhibit CYP450 Human Liver Microsome
disjoint with: EV EX Met Enz Inhibit CYP450 Human Recom
disjoint with: EV Non Traceable Statement
disjoint with: EV Observational
disjoint with: EV PK DDI NR
disjoint with: EV PK DDI Observational
disjoint with: EV PK DDI Par Grps
disjoint with: EV PK DDI RCT
disjoint with: EV Population PK
disjoint with: EV Review
disjoint with: EV Statement
disjoint with: EV Traceable Statement
disjoint with: Enzyme
disjoint with: Increased Drug AUC
disjoint with: Increased Drug Level
disjoint with: Induction
disjoint with: Inhibition
disjoint with: Inhibitor
disjoint with: Journal Peer reviewed
disjoint with: Metabolism
disjoint with: Microsomes
disjoint with: Non randomized Tx Assignment
disjoint with: Observation based DI Report Assessment tool
disjoint with: PK DDI
disjoint with: Pharmacodynamic Effect Consequences
disjoint with: Pharmacokinetic Effect Consequences
disjoint with: Pharmacokinetic Process
disjoint with: Public Reporting Database
disjoint with: Randomized Tx Assignment
disjoint with: Recombinant Protein System
disjoint with: Treatment Assignment
disjoint with: Xenobiotic Metabolism
disjoint with: in vitro Protein Source
disjoint with: BiochemicalReaction
disjoint with: Catalysis
disjoint with: Complex
disjoint with: ComplexAssembly
disjoint with: Control
disjoint with: Conversion
disjoint with: Degradation
disjoint with: Dna
disjoint with: DnaRegion
disjoint with: Entity
disjoint with: Gene
disjoint with: GeneticInteraction
disjoint with: Interaction
disjoint with: Modulation
disjoint with: MolecularInteraction
disjoint with: Pathway
disjoint with: PhysicalEntity
disjoint with: Protein
disjoint with: Rna
disjoint with: RnaRegion
disjoint with: SmallMolecule
disjoint with: TemplateReaction
disjoint with: TemplateReactionRegulation
disjoint with: Transport
disjoint with: TransportWithBiochemicalReaction
comment: "A study of the process by which a drug is absorbed, distributed, metabolized, and eliminated by the body." NCI code C49663
description: A pharmacokinetic clinical trial

EV CT Pharmacokinetic Data
type: Class
subclass of: EV Clinical Trial Data
disjoint with: EV Case Report ADE Data
disjoint with: EV Case Report ADE Public Reported Data
disjoint with: EV Case Report DI CR Data
disjoint with: EV Case Report DI CR Evaluated Data
disjoint with: EV Case Report Data
disjoint with: EV EX Met Enz ID CYP450 Data
disjoint with: EV EX Met Enz ID CYP450 Hum Liver Microsome Antibody Data
disjoint with: EV EX Met Enz ID CYP450 Hum Liver Microsome Chem Data
disjoint with: EV EX Met Enz ID CYP450 Hum Liver Microsome Data
disjoint with: EV EX Met Enz ID CYP450 Hum Recom Antibody Data
disjoint with: EV EX Met Enz ID CYP450 Hum Recom Chem Data
disjoint with: EV EX Met Enz ID CYP450 Hum Recom Data
disjoint with: EV EX Met Enz ID Data
disjoint with: EV EX Met Enz Inhibit CYP450 Data
disjoint with: EV EX Met Enz Inhibit CYP450 Human Liver Microsome Data
disjoint with: EV EX Met Enz Inhibit CYP450 Human Recom Data
disjoint with: EV EX Met Enz Inhibit Data
disjoint with: EV Observational Data
disjoint with: EV PK DDI NR Data
disjoint with: EV PK DDI Observational Data
disjoint with: EV PK DDI Par Grps Data
disjoint with: EV PK DDI RCT Data
disjoint with: EV Population PK Data
disjoint with: Enzyme
disjoint with: Increased Drug AUC
disjoint with: Increased Drug Level
disjoint with: Induction
disjoint with: Inhibition
disjoint with: Inhibitor
disjoint with: Journal Peer reviewed
disjoint with: Metabolism
disjoint with: Microsomes
disjoint with: Non randomized Tx Assignment
disjoint with: Observation based DI Report Assessment tool
disjoint with: PK DDI
disjoint with: Pharmacodynamic Effect Consequences
disjoint with: Pharmacokinetic Effect Consequences
disjoint with: Pharmacokinetic Process
disjoint with: Public Reporting Database
disjoint with: Randomized Tx Assignment
disjoint with: Recombinant Protein System
disjoint with: Treatment Assignment
disjoint with: Xenobiotic Metabolism
disjoint with: in vitro Protein Source
disjoint with: BiochemicalReaction
disjoint with: Catalysis
disjoint with: Complex
disjoint with: ComplexAssembly
disjoint with: Control
disjoint with: Conversion
disjoint with: Degradation
disjoint with: Dna
disjoint with: DnaRegion
disjoint with: Entity
disjoint with: Gene
disjoint with: GeneticInteraction
disjoint with: Interaction
disjoint with: Modulation
disjoint with: MolecularInteraction
disjoint with: Pathway
disjoint with: PhysicalEntity
disjoint with: Protein
disjoint with: Rna
disjoint with: RnaRegion
disjoint with: SmallMolecule
disjoint with: TemplateReaction
disjoint with: TemplateReactionRegulation
disjoint with: Transport
disjoint with: TransportWithBiochemicalReaction
description: Data from a pharmacokinetic study, which is defined as: "A study of the process by which a drug is absorbed, distributed, metabolized, and eliminated by the body." NCI code C49663

EV CT Pharmacokinetic Material
type: Class
subclass of: EV Clinical Trial Material
disjoint with: EV Case Report ADE Material
disjoint with: EV Case Report ADE Public Reported Material
disjoint with: EV Case Report DI CR Evaluated Material
disjoint with: EV Case Report DI CR Material
disjoint with: EV Case Report Material
disjoint with: EV EX Met Enz ID CYP450 Hum Liver Microsome Antibody Material
disjoint with: EV EX Met Enz ID CYP450 Hum Liver Microsome Chem Material
disjoint with: EV EX Met Enz ID CYP450 Hum Liver Microsome Material
disjoint with: EV EX Met Enz ID CYP450 Hum Recom Antibody Material
disjoint with: EV EX Met Enz ID CYP450 Hum Recom Chem Material
disjoint with: EV EX Met Enz ID CYP450 Hum Recom Material
disjoint with: EV EX Met Enz ID CYP450 Material
disjoint with: EV EX Met Enz ID Material
disjoint with: EV EX Met Enz Inhibit CYP450 Human Liver Microsome Material
disjoint with: EV EX Met Enz Inhibit CYP450 Human Recom Material
disjoint with: EV EX Met Enz Inhibit CYP450 Material
disjoint with: EV EX Met Enz Inhibit Material
disjoint with: EV Observational Material
disjoint with: EV PK DDI NR Material
disjoint with: EV PK DDI Observational Material
disjoint with: EV PK DDI Par Grps Material
disjoint with: EV PK DDI RCT Material
disjoint with: EV Population PK Material
disjoint with: Enzyme
disjoint with: Increased Drug AUC
disjoint with: Increased Drug Level
disjoint with: Induction
disjoint with: Inhibition
disjoint with: Inhibitor
disjoint with: Journal Peer reviewed
disjoint with: Metabolism
disjoint with: Microsomes
disjoint with: Non randomized Tx Assignment
disjoint with: Observation based DI Report Assessment tool
disjoint with: PK DDI
disjoint with: Pharmacodynamic Effect Consequences
disjoint with: Pharmacokinetic Effect Consequences
disjoint with: Pharmacokinetic Process
disjoint with: Public Reporting Database
disjoint with: Randomized Tx Assignment
disjoint with: Recombinant Protein System
disjoint with: Treatment Assignment
disjoint with: Xenobiotic Metabolism
disjoint with: in vitro Protein Source
disjoint with: BiochemicalReaction
disjoint with: Catalysis
disjoint with: Complex
disjoint with: ComplexAssembly
disjoint with: Control
disjoint with: Conversion
disjoint with: Degradation
disjoint with: Dna
disjoint with: DnaRegion
disjoint with: Entity
disjoint with: Gene
disjoint with: GeneticInteraction
disjoint with: Interaction
disjoint with: Modulation
disjoint with: MolecularInteraction
disjoint with: Pathway
disjoint with: PhysicalEntity
disjoint with: Protein
disjoint with: Rna
disjoint with: RnaRegion
disjoint with: SmallMolecule
disjoint with: TemplateReaction
disjoint with: TemplateReactionRegulation
disjoint with: Transport
disjoint with: TransportWithBiochemicalReaction
description: Material from a pharmacokinetic study, which is defined as: "A study of the process by which a drug is absorbed, distributed, metabolized, and eliminated by the body." NCI code C49663

EV Case Report
type: Class
equivalent class: Restriction
  on property: has study design
  some values from: case study
subclass of: Evidence Type
disjoint with: EV Clinical Trial
disjoint with: EV DrugClinicalReview
disjoint with: EV Drug Review
disjoint with: EV EX Met Enz ID
disjoint with: EV EX Met Enz ID CYP450
disjoint with: EV EX Met Enz ID CYP450 Hum Liver Microsome
disjoint with: EV EX Met Enz ID CYP450 Hum Liver Microsome Antibody
disjoint with: EV EX Met Enz ID CYP450 Hum Liver Microsome Chem
disjoint with: EV EX Met Enz ID CYP450 Hum Recom
disjoint with: EV EX Met Enz ID CYP450 Hum Recom Antibody
disjoint with: EV EX Met Enz ID CYP450 Hum Recom Chem
disjoint with: EV EX Met Enz Inhibit
disjoint with: EV EX Met Enz Inhibit CYP450
disjoint with: EV EX Met Enz Inhibit CYP450 Human Liver Microsome
disjoint with: EV EX Met Enz Inhibit CYP450 Human Recom
disjoint with: EV Non Traceable Statement
disjoint with: EV Observational
disjoint with: EV PK DDI NR
disjoint with: EV PK DDI Observational
disjoint with: EV PK DDI Par Grps
disjoint with: EV PK DDI RCT
disjoint with: EV Population PK
disjoint with: EV Review
disjoint with: EV Statement
disjoint with: EV Traceable Statement
disjoint with: Enzyme
disjoint with: Increased Drug AUC
disjoint with: Increased Drug Level
disjoint with: Induction
disjoint with: Inhibition
disjoint with: Inhibitor
disjoint with: Journal Peer reviewed
disjoint with: Metabolism
disjoint with: Microsomes
disjoint with: Non randomized Tx Assignment
disjoint with: Observation based DI Report Assessment tool
disjoint with: PK DDI
disjoint with: Pharmacodynamic Effect Consequences
disjoint with: Pharmacokinetic Effect Consequences
disjoint with: Pharmacokinetic Process
disjoint with: Public Reporting Database
disjoint with: Randomized Tx Assignment
disjoint with: Recombinant Protein System
disjoint with: Treatment Assignment
disjoint with: Xenobiotic Metabolism
disjoint with: in vitro Protein Source
disjoint with: BiochemicalReaction
disjoint with: Catalysis
disjoint with: Complex
disjoint with: ComplexAssembly
disjoint with: Control
disjoint with: Conversion
disjoint with: Degradation
disjoint with: Dna
disjoint with: DnaRegion
disjoint with: Entity
disjoint with: Gene
disjoint with: GeneticInteraction
disjoint with: Interaction
disjoint with: Modulation
disjoint with: MolecularInteraction
disjoint with: Pathway
disjoint with: PhysicalEntity
disjoint with: Protein
disjoint with: Rna
disjoint with: RnaRegion
disjoint with: SmallMolecule
disjoint with: TemplateReaction
disjoint with: TemplateReactionRegulation
disjoint with: Transport
disjoint with: TransportWithBiochemicalReaction
comment: An observation-based report of some occurrence
description: An observation-based report

EV Case Report ADE
type: Class
equivalent class: Class
  intersection of: EV Case Report
  intersection of: Restriction
    on property: describes
    some values from: Class
      union of: Pharmacodynamic Effect Consequences
      union of: Pharmacokinetic Effect Consequences
  intersection of: Restriction
    on property: describes
    all values from: Class
      union of: Pharmacodynamic Effect Consequences
      union of: Pharmacokinetic Effect Consequences
subclass of: EV Case Report
disjoint with: EV Clinical Trial
disjoint with: EV DrugClinicalReview
disjoint with: EV Drug Review
disjoint with: EV EX Met Enz ID
disjoint with: EV EX Met Enz ID CYP450
disjoint with: EV EX Met Enz ID CYP450 Hum Liver Microsome
disjoint with: EV EX Met Enz ID CYP450 Hum Liver Microsome Antibody
disjoint with: EV EX Met Enz ID CYP450 Hum Liver Microsome Chem
disjoint with: EV EX Met Enz ID CYP450 Hum Recom
disjoint with: EV EX Met Enz ID CYP450 Hum Recom Antibody
disjoint with: EV EX Met Enz ID CYP450 Hum Recom Chem
disjoint with: EV EX Met Enz Inhibit
disjoint with: EV EX Met Enz Inhibit CYP450
disjoint with: EV EX Met Enz Inhibit CYP450 Human Liver Microsome
disjoint with: EV EX Met Enz Inhibit CYP450 Human Recom
disjoint with: EV Non Traceable Statement
disjoint with: EV Observational
disjoint with: EV PK DDI NR
disjoint with: EV PK DDI Observational
disjoint with: EV PK DDI Par Grps
disjoint with: EV PK DDI RCT
disjoint with: EV Population PK
disjoint with: EV Review
disjoint with: EV Statement
disjoint with: EV Traceable Statement
disjoint with: Enzyme
disjoint with: Increased Drug AUC
disjoint with: Increased Drug Level
disjoint with: Induction
disjoint with: Inhibition
disjoint with: Inhibitor
disjoint with: Journal Peer reviewed
disjoint with: Metabolism
disjoint with: Microsomes
disjoint with: Non randomized Tx Assignment
disjoint with: Observation based DI Report Assessment tool
disjoint with: PK DDI
disjoint with: Pharmacodynamic Effect Consequences
disjoint with: Pharmacokinetic Effect Consequences
disjoint with: Pharmacokinetic Process
disjoint with: Public Reporting Database
disjoint with: Randomized Tx Assignment
disjoint with: Recombinant Protein System
disjoint with: Treatment Assignment
disjoint with: Xenobiotic Metabolism
disjoint with: in vitro Protein Source
disjoint with: BiochemicalReaction
disjoint with: Catalysis
disjoint with: Complex
disjoint with: ComplexAssembly
disjoint with: Control
disjoint with: Conversion
disjoint with: Degradation
disjoint with: Dna
disjoint with: DnaRegion
disjoint with: Entity
disjoint with: Gene
disjoint with: GeneticInteraction
disjoint with: Interaction
disjoint with: Modulation
disjoint with: MolecularInteraction
disjoint with: Pathway
disjoint with: PhysicalEntity
disjoint with: Protein
disjoint with: Rna
disjoint with: RnaRegion
disjoint with: SmallMolecule
disjoint with: TemplateReaction
disjoint with: TemplateReactionRegulation
disjoint with: Transport
disjoint with: TransportWithBiochemicalReaction
comment: An observation-based report of an adverse drug event
description: An observation-based ADE report

EV Case Report ADE Data
type: Class
subclass of: EV Case Report Data
disjoint with: EV Clinical Trial Data
disjoint with: EV EX Met Enz ID CYP450 Data
disjoint with: EV EX Met Enz ID CYP450 Hum Liver Microsome Antibody Data
disjoint with: EV EX Met Enz ID CYP450 Hum Liver Microsome Chem Data
disjoint with: EV EX Met Enz ID CYP450 Hum Liver Microsome Data
disjoint with: EV EX Met Enz ID CYP450 Hum Recom Antibody Data
disjoint with: EV EX Met Enz ID CYP450 Hum Recom Chem Data
disjoint with: EV EX Met Enz ID CYP450 Hum Recom Data
disjoint with: EV EX Met Enz ID Data
disjoint with: EV EX Met Enz Inhibit CYP450 Data
disjoint with: EV EX Met Enz Inhibit CYP450 Human Liver Microsome Data
disjoint with: EV EX Met Enz Inhibit CYP450 Human Recom Data
disjoint with: EV EX Met Enz Inhibit Data
disjoint with: EV Observational Data
disjoint with: EV PK DDI NR Data
disjoint with: EV PK DDI Observational Data
disjoint with: EV PK DDI Par Grps Data
disjoint with: EV PK DDI RCT Data
disjoint with: EV Population PK Data
disjoint with: Enzyme
disjoint with: Increased Drug AUC
disjoint with: Increased Drug Level
disjoint with: Induction
disjoint with: Inhibition
disjoint with: Inhibitor
disjoint with: Journal Peer reviewed
disjoint with: Metabolism
disjoint with: Microsomes
disjoint with: Non randomized Tx Assignment
disjoint with: Observation based DI Report Assessment tool
disjoint with: PK DDI
disjoint with: Pharmacodynamic Effect Consequences
disjoint with: Pharmacokinetic Effect Consequences
disjoint with: Pharmacokinetic Process
disjoint with: Public Reporting Database
disjoint with: Randomized Tx Assignment
disjoint with: Recombinant Protein System
disjoint with: Treatment Assignment
disjoint with: Xenobiotic Metabolism
disjoint with: in vitro Protein Source
disjoint with: BiochemicalReaction
disjoint with: Catalysis
disjoint with: Complex
disjoint with: ComplexAssembly
disjoint with: Control
disjoint with: Conversion
disjoint with: Degradation
disjoint with: Dna
disjoint with: DnaRegion
disjoint with: Entity
disjoint with: Gene
disjoint with: GeneticInteraction
disjoint with: Interaction
disjoint with: Modulation
disjoint with: MolecularInteraction
disjoint with: Pathway
disjoint with: PhysicalEntity
disjoint with: Protein
disjoint with: Rna
disjoint with: RnaRegion
disjoint with: SmallMolecule
disjoint with: TemplateReaction
disjoint with: TemplateReactionRegulation
disjoint with: Transport
disjoint with: TransportWithBiochemicalReaction
description: The data from an observation-based adverse drug event (ADE) report

EV Case Report ADE Material
type: Class
subclass of: EV Case Report Material
disjoint with: EV Clinical Trial Material
disjoint with: EV EX Met Enz ID CYP450 Hum Liver Microsome Antibody Material
disjoint with: EV EX Met Enz ID CYP450 Hum Liver Microsome Chem Material
disjoint with: EV EX Met Enz ID CYP450 Hum Liver Microsome Material
disjoint with: EV EX Met Enz ID CYP450 Hum Recom Antibody Material
disjoint with: EV EX Met Enz ID CYP450 Hum Recom Chem Material
disjoint with: EV EX Met Enz ID CYP450 Hum Recom Material
disjoint with: EV EX Met Enz ID CYP450 Material
disjoint with: EV EX Met Enz ID Material
disjoint with: EV EX Met Enz Inhibit CYP450 Human Liver Microsome Material
disjoint with: EV EX Met Enz Inhibit CYP450 Human Recom Material
disjoint with: EV EX Met Enz Inhibit CYP450 Material
disjoint with: EV EX Met Enz Inhibit Material
disjoint with: EV Observational Material
disjoint with: EV PK DDI NR Material
disjoint with: EV PK DDI Observational Material
disjoint with: EV PK DDI Par Grps Material
disjoint with: EV PK DDI RCT Material
disjoint with: EV Population PK Material
disjoint with: Enzyme
disjoint with: Increased Drug AUC
disjoint with: Increased Drug Level
disjoint with: Induction
disjoint with: Inhibition
disjoint with: Inhibitor
disjoint with: Journal Peer reviewed
disjoint with: Metabolism
disjoint with: Microsomes
disjoint with: Non randomized Tx Assignment
disjoint with: Observation based DI Report Assessment tool
disjoint with: PK DDI
disjoint with: Pharmacodynamic Effect Consequences
disjoint with: Pharmacokinetic Effect Consequences
disjoint with: Pharmacokinetic Process
disjoint with: Public Reporting Database
disjoint with: Randomized Tx Assignment
disjoint with: Recombinant Protein System
disjoint with: Treatment Assignment
disjoint with: Xenobiotic Metabolism
disjoint with: in vitro Protein Source
disjoint with: BiochemicalReaction
disjoint with: Catalysis
disjoint with: Complex
disjoint with: ComplexAssembly
disjoint with: Control
disjoint with: Conversion
disjoint with: Degradation
disjoint with: Dna
disjoint with: DnaRegion
disjoint with: Entity
disjoint with: Gene
disjoint with: GeneticInteraction
disjoint with: Interaction
disjoint with: Modulation
disjoint with: MolecularInteraction
disjoint with: Pathway
disjoint with: PhysicalEntity
disjoint with: Protein
disjoint with: Rna
disjoint with: RnaRegion
disjoint with: SmallMolecule
disjoint with: TemplateReaction
disjoint with: TemplateReactionRegulation
disjoint with: Transport
disjoint with: TransportWithBiochemicalReaction
description: The material from an observation-based adverse drug event (ADE) report

EV Case Report ADE Public Reported
type: Class
equivalent class: Class
  intersection of: EV Case Report ADE
  intersection of: Restriction
    on property: is recorded in
    some values from: Public Reporting Database
  intersection of: Restriction
    on property: is recorded in
    all values from: Public Reporting Database
subclass of: EV Case Report ADE
disjoint with: EV Clinical Trial
disjoint with: EV DrugClinicalReview
disjoint with: EV Drug Review
disjoint with: EV EX Met Enz ID
disjoint with: EV EX Met Enz ID CYP450
disjoint with: EV EX Met Enz ID CYP450 Hum Liver Microsome
disjoint with: EV EX Met Enz ID CYP450 Hum Liver Microsome Antibody
disjoint with: EV EX Met Enz ID CYP450 Hum Liver Microsome Chem
disjoint with: EV EX Met Enz ID CYP450 Hum Recom
disjoint with: EV EX Met Enz ID CYP450 Hum Recom Antibody
disjoint with: EV EX Met Enz ID CYP450 Hum Recom Chem
disjoint with: EV EX Met Enz Inhibit
disjoint with: EV EX Met Enz Inhibit CYP450
disjoint with: EV EX Met Enz Inhibit CYP450 Human Liver Microsome
disjoint with: EV EX Met Enz Inhibit CYP450 Human Recom
disjoint with: EV Non Traceable Statement
disjoint with: EV Observational
disjoint with: EV PK DDI NR
disjoint with: EV PK DDI Observational
disjoint with: EV PK DDI Par Grps
disjoint with: EV PK DDI RCT
disjoint with: EV Population PK
disjoint with: EV Review
disjoint with: EV Statement
disjoint with: EV Traceable Statement
disjoint with: Enzyme
disjoint with: Increased Drug AUC
disjoint with: Increased Drug Level
disjoint with: Induction
disjoint with: Inhibition
disjoint with: Inhibitor
disjoint with: Journal Peer reviewed
disjoint with: Metabolism
disjoint with: Microsomes
disjoint with: Non randomized Tx Assignment
disjoint with: Observation based DI Report Assessment tool
disjoint with: PK DDI
disjoint with: Pharmacodynamic Effect Consequences
disjoint with: Pharmacokinetic Effect Consequences
disjoint with: Pharmacokinetic Process
disjoint with: Public Reporting Database
disjoint with: Randomized Tx Assignment
disjoint with: Recombinant Protein System
disjoint with: Treatment Assignment
disjoint with: Xenobiotic Metabolism
disjoint with: in vitro Protein Source
disjoint with: BiochemicalReaction
disjoint with: Catalysis
disjoint with: Complex
disjoint with: ComplexAssembly
disjoint with: Control
disjoint with: Conversion
disjoint with: Degradation
disjoint with: Dna
disjoint with: DnaRegion
disjoint with: Entity
disjoint with: Gene
disjoint with: GeneticInteraction
disjoint with: Interaction
disjoint with: Modulation
disjoint with: MolecularInteraction
disjoint with: Pathway
disjoint with: PhysicalEntity
disjoint with: Protein
disjoint with: Rna
disjoint with: RnaRegion
disjoint with: SmallMolecule
disjoint with: TemplateReaction
disjoint with: TemplateReactionRegulation
disjoint with: Transport
disjoint with: TransportWithBiochemicalReaction
comment: An adverse drug event report on file in a public adverse event reporting database such as the FDA's Adverse Event Reporting System
description: An observation-based ADE report in a public reporting database

EV Case Report ADE Public Reported Data
type: Class
subclass of: EV Case Report ADE Data
disjoint with: EV Clinical Trial Data
disjoint with: EV EX Met Enz ID CYP450 Data
disjoint with: EV EX Met Enz ID CYP450 Hum Liver Microsome Antibody Data
disjoint with: EV EX Met Enz ID CYP450 Hum Liver Microsome Chem Data
disjoint with: EV EX Met Enz ID CYP450 Hum Liver Microsome Data
disjoint with: EV EX Met Enz ID CYP450 Hum Recom Antibody Data
disjoint with: EV EX Met Enz ID CYP450 Hum Recom Chem Data
disjoint with: EV EX Met Enz ID CYP450 Hum Recom Data
disjoint with: EV EX Met Enz ID Data
disjoint with: EV EX Met Enz Inhibit CYP450 Data
disjoint with: EV EX Met Enz Inhibit CYP450 Human Liver Microsome Data
disjoint with: EV EX Met Enz Inhibit CYP450 Human Recom Data
disjoint with: EV EX Met Enz Inhibit Data
disjoint with: EV Observational Data
disjoint with: EV PK DDI NR Data
disjoint with: EV PK DDI Observational Data
disjoint with: EV PK DDI Par Grps Data
disjoint with: EV PK DDI RCT Data
disjoint with: EV Population PK Data
disjoint with: Enzyme
disjoint with: Increased Drug AUC
disjoint with: Increased Drug Level
disjoint with: Induction
disjoint with: Inhibition
disjoint with: Inhibitor
disjoint with: Journal Peer reviewed
disjoint with: Metabolism
disjoint with: Microsomes
disjoint with: Non randomized Tx Assignment
disjoint with: Observation based DI Report Assessment tool
disjoint with: PK DDI
disjoint with: Pharmacodynamic Effect Consequences
disjoint with: Pharmacokinetic Effect Consequences
disjoint with: Pharmacokinetic Process
disjoint with: Public Reporting Database
disjoint with: Randomized Tx Assignment
disjoint with: Recombinant Protein System
disjoint with: Treatment Assignment
disjoint with: Xenobiotic Metabolism
disjoint with: in vitro Protein Source
disjoint with: BiochemicalReaction
disjoint with: Catalysis
disjoint with: Complex
disjoint with: ComplexAssembly
disjoint with: Control
disjoint with: Conversion
disjoint with: Degradation
disjoint with: Dna
disjoint with: DnaRegion
disjoint with: Entity
disjoint with: Gene
disjoint with: GeneticInteraction
disjoint with: Interaction
disjoint with: Modulation
disjoint with: MolecularInteraction
disjoint with: Pathway
disjoint with: PhysicalEntity
disjoint with: Protein
disjoint with: Rna
disjoint with: RnaRegion
disjoint with: SmallMolecule
disjoint with: TemplateReaction
disjoint with: TemplateReactionRegulation
disjoint with: Transport
disjoint with: TransportWithBiochemicalReaction
description: The data from an observation-based adverse drug event (ADE) report on file in a public ADE reporting database such as the FDA's Adverse Event Reporting System

EV Case Report ADE Public Reported Material
type: Class
subclass of: EV Case Report ADE Material
disjoint with: EV Clinical Trial Material
disjoint with: EV EX Met Enz ID CYP450 Hum Liver Microsome Antibody Material
disjoint with: EV EX Met Enz ID CYP450 Hum Liver Microsome Chem Material
disjoint with: EV EX Met Enz ID CYP450 Hum Liver Microsome Material
disjoint with: EV EX Met Enz ID CYP450 Hum Recom Antibody Material
disjoint with: EV EX Met Enz ID CYP450 Hum Recom Chem Material
disjoint with: EV EX Met Enz ID CYP450 Hum Recom Material
disjoint with: EV EX Met Enz ID CYP450 Material
disjoint with: EV EX Met Enz ID Material
disjoint with: EV EX Met Enz Inhibit CYP450 Human Liver Microsome Material
disjoint with: EV EX Met Enz Inhibit CYP450 Human Recom Material
disjoint with: EV EX Met Enz Inhibit CYP450 Material
disjoint with: EV EX Met Enz Inhibit Material
disjoint with: EV Observational Material
disjoint with: EV PK DDI NR Material
disjoint with: EV PK DDI Observational Material
disjoint with: EV PK DDI Par Grps Material
disjoint with: EV PK DDI RCT Material
disjoint with: EV Population PK Material
disjoint with: Enzyme
disjoint with: Increased Drug AUC
disjoint with: Increased Drug Level
disjoint with: Induction
disjoint with: Inhibition
disjoint with: Inhibitor
disjoint with: Journal Peer reviewed
disjoint with: Metabolism
disjoint with: Microsomes
disjoint with: Non randomized Tx Assignment
disjoint with: Observation based DI Report Assessment tool
disjoint with: PK DDI
disjoint with: Pharmacodynamic Effect Consequences
disjoint with: Pharmacokinetic Effect Consequences
disjoint with: Pharmacokinetic Process
disjoint with: Public Reporting Database
disjoint with: Randomized Tx Assignment
disjoint with: Recombinant Protein System
disjoint with: Treatment Assignment
disjoint with: Xenobiotic Metabolism
disjoint with: in vitro Protein Source
disjoint with: BiochemicalReaction
disjoint with: Catalysis
disjoint with: Complex
disjoint with: ComplexAssembly
disjoint with: Control
disjoint with: Conversion
disjoint with: Degradation
disjoint with: Dna
disjoint with: DnaRegion
disjoint with: Entity
disjoint with: Gene
disjoint with: GeneticInteraction
disjoint with: Interaction
disjoint with: Modulation
disjoint with: MolecularInteraction
disjoint with: Pathway
disjoint with: PhysicalEntity
disjoint with: Protein
disjoint with: Rna
disjoint with: RnaRegion
disjoint with: SmallMolecule
disjoint with: TemplateReaction
disjoint with: TemplateReactionRegulation
disjoint with: Transport
disjoint with: TransportWithBiochemicalReaction
description: The material from an observation-based adverse drug event (ADE) report on file in a public ADE reporting database such as the FDA's Adverse Event Reporting System

EV Case Report DI CR
type: Class
equivalent class: Class
  intersection of: EV Case Report ADE
  intersection of: Restriction
    on property: is published in
    some values from: Journal Peer reviewed
  intersection of: Restriction
    on property: is published in
    all values from: Journal Peer reviewed
subclass of: EV Case Report ADE
disjoint with: EV Clinical Trial
disjoint with: EV DrugClinicalReview
disjoint with: EV Drug Review
disjoint with: EV EX Met Enz ID
disjoint with: EV EX Met Enz ID CYP450
disjoint with: EV EX Met Enz ID CYP450 Hum Liver Microsome
disjoint with: EV EX Met Enz ID CYP450 Hum Liver Microsome Antibody
disjoint with: EV EX Met Enz ID CYP450 Hum Liver Microsome Chem
disjoint with: EV EX Met Enz ID CYP450 Hum Recom
disjoint with: EV EX Met Enz ID CYP450 Hum Recom Antibody
disjoint with: EV EX Met Enz ID CYP450 Hum Recom Chem
disjoint with: EV EX Met Enz Inhibit
disjoint with: EV EX Met Enz Inhibit CYP450
disjoint with: EV EX Met Enz Inhibit CYP450 Human Liver Microsome
disjoint with: EV EX Met Enz Inhibit CYP450 Human Recom
disjoint with: EV Non Traceable Statement
disjoint with: EV Observational
disjoint with: EV PK DDI NR
disjoint with: EV PK DDI Observational
disjoint with: EV PK DDI Par Grps
disjoint with: EV PK DDI RCT
disjoint with: EV Population PK
disjoint with: EV Review
disjoint with: EV Statement
disjoint with: EV Traceable Statement
disjoint with: Enzyme
disjoint with: Increased Drug AUC
disjoint with: Increased Drug Level
disjoint with: Induction
disjoint with: Inhibition
disjoint with: Inhibitor
disjoint with: Journal Peer reviewed
disjoint with: Metabolism
disjoint with: Microsomes
disjoint with: Non randomized Tx Assignment
disjoint with: Observation based DI Report Assessment tool
disjoint with: PK DDI
disjoint with: Pharmacodynamic Effect Consequences
disjoint with: Pharmacokinetic Effect Consequences
disjoint with: Pharmacokinetic Process
disjoint with: Public Reporting Database
disjoint with: Randomized Tx Assignment
disjoint with: Recombinant Protein System
disjoint with: Treatment Assignment
disjoint with: Xenobiotic Metabolism
disjoint with: in vitro Protein Source
disjoint with: BiochemicalReaction
disjoint with: Catalysis
disjoint with: Complex
disjoint with: ComplexAssembly
disjoint with: Control
disjoint with: Conversion
disjoint with: Degradation
disjoint with: Dna
disjoint with: DnaRegion
disjoint with: Entity
disjoint with: Gene
disjoint with: GeneticInteraction
disjoint with: Interaction
disjoint with: Modulation
disjoint with: MolecularInteraction
disjoint with: Pathway
disjoint with: PhysicalEntity
disjoint with: Protein
disjoint with: Rna
disjoint with: RnaRegion
disjoint with: SmallMolecule
disjoint with: TemplateReaction
disjoint with: TemplateReactionRegulation
disjoint with: Transport
disjoint with: TransportWithBiochemicalReaction
comment: An published observation-based case-report of a drug interaction
description: A published observation-based ADE report

EV Case Report DI CR Data
type: Class
subclass of: EV Case Report ADE Data
disjoint with: EV Clinical Trial Data
disjoint with: EV EX Met Enz ID CYP450 Data
disjoint with: EV EX Met Enz ID CYP450 Hum Liver Microsome Antibody Data
disjoint with: EV EX Met Enz ID CYP450 Hum Liver Microsome Chem Data
disjoint with: EV EX Met Enz ID CYP450 Hum Liver Microsome Data
disjoint with: EV EX Met Enz ID CYP450 Hum Recom Antibody Data
disjoint with: EV EX Met Enz ID CYP450 Hum Recom Chem Data
disjoint with: EV EX Met Enz ID CYP450 Hum Recom Data
disjoint with: EV EX Met Enz ID Data
disjoint with: EV EX Met Enz Inhibit CYP450 Data
disjoint with: EV EX Met Enz Inhibit CYP450 Human Liver Microsome Data
disjoint with: EV EX Met Enz Inhibit CYP450 Human Recom Data
disjoint with: EV EX Met Enz Inhibit Data
disjoint with: EV Observational Data
disjoint with: EV PK DDI NR Data
disjoint with: EV PK DDI Observational Data
disjoint with: EV PK DDI Par Grps Data
disjoint with: EV PK DDI RCT Data
disjoint with: EV Population PK Data
disjoint with: Enzyme
disjoint with: Increased Drug AUC
disjoint with: Increased Drug Level
disjoint with: Induction
disjoint with: Inhibition
disjoint with: Inhibitor
disjoint with: Journal Peer reviewed
disjoint with: Metabolism
disjoint with: Microsomes
disjoint with: Non randomized Tx Assignment
disjoint with: Observation based DI Report Assessment tool
disjoint with: PK DDI
disjoint with: Pharmacodynamic Effect Consequences
disjoint with: Pharmacokinetic Effect Consequences
disjoint with: Pharmacokinetic Process
disjoint with: Public Reporting Database
disjoint with: Randomized Tx Assignment
disjoint with: Recombinant Protein System
disjoint with: Treatment Assignment
disjoint with: Xenobiotic Metabolism
disjoint with: in vitro Protein Source
disjoint with: BiochemicalReaction
disjoint with: Catalysis
disjoint with: Complex
disjoint with: ComplexAssembly
disjoint with: Control
disjoint with: Conversion
disjoint with: Degradation
disjoint with: Dna
disjoint with: DnaRegion
disjoint with: Entity
disjoint with: Gene
disjoint with: GeneticInteraction
disjoint with: Interaction
disjoint with: Modulation
disjoint with: MolecularInteraction
disjoint with: Pathway
disjoint with: PhysicalEntity
disjoint with: Protein
disjoint with: Rna
disjoint with: RnaRegion
disjoint with: SmallMolecule
disjoint with: TemplateReaction
disjoint with: TemplateReactionRegulation
disjoint with: Transport
disjoint with: TransportWithBiochemicalReaction
description: The data from a published observation-based case-report of a drug interaction

EV Case Report DI CR Evaluated
type: Class
equivalent class: Class
  intersection of: EV Case Report DI CR
  intersection of: Restriction
    on property: has been evaluated by
    some values from: Observation based DI Report Assessment tool
  intersection of: Restriction
    on property: has been evaluated by
    all values from: Observation based DI Report Assessment tool
subclass of: EV Case Report DI CR
disjoint with: EV Clinical Trial
disjoint with: EV DrugClinicalReview
disjoint with: EV Drug Review
disjoint with: EV EX Met Enz ID
disjoint with: EV EX Met Enz ID CYP450
disjoint with: EV EX Met Enz ID CYP450 Hum Liver Microsome
disjoint with: EV EX Met Enz ID CYP450 Hum Liver Microsome Antibody
disjoint with: EV EX Met Enz ID CYP450 Hum Liver Microsome Chem
disjoint with: EV EX Met Enz ID CYP450 Hum Recom
disjoint with: EV EX Met Enz ID CYP450 Hum Recom Antibody
disjoint with: EV EX Met Enz ID CYP450 Hum Recom Chem
disjoint with: EV EX Met Enz Inhibit
disjoint with: EV EX Met Enz Inhibit CYP450
disjoint with: EV EX Met Enz Inhibit CYP450 Human Liver Microsome
disjoint with: EV EX Met Enz Inhibit CYP450 Human Recom
disjoint with: EV Non Traceable Statement
disjoint with: EV Observational
disjoint with: EV PK DDI NR
disjoint with: EV PK DDI Observational
disjoint with: EV PK DDI Par Grps
disjoint with: EV PK DDI RCT
disjoint with: EV Population PK
disjoint with: EV Review
disjoint with: EV Statement
disjoint with: EV Traceable Statement
disjoint with: Enzyme
disjoint with: Increased Drug AUC
disjoint with: Increased Drug Level
disjoint with: Induction
disjoint with: Inhibition
disjoint with: Inhibitor
disjoint with: Journal Peer reviewed
disjoint with: Metabolism
disjoint with: Microsomes
disjoint with: Non randomized Tx Assignment
disjoint with: Observation based DI Report Assessment tool
disjoint with: PK DDI
disjoint with: Pharmacodynamic Effect Consequences
disjoint with: Pharmacokinetic Effect Consequences
disjoint with: Pharmacokinetic Process
disjoint with: Public Reporting Database
disjoint with: Randomized Tx Assignment
disjoint with: Recombinant Protein System
disjoint with: Treatment Assignment
disjoint with: Xenobiotic Metabolism
disjoint with: in vitro Protein Source
disjoint with: BiochemicalReaction
disjoint with: Catalysis
disjoint with: Complex
disjoint with: ComplexAssembly
disjoint with: Control
disjoint with: Conversion
disjoint with: Degradation
disjoint with: Dna
disjoint with: DnaRegion
disjoint with: Entity
disjoint with: Gene
disjoint with: GeneticInteraction
disjoint with: Interaction
disjoint with: Modulation
disjoint with: MolecularInteraction
disjoint with: Pathway
disjoint with: PhysicalEntity
disjoint with: Protein
disjoint with: Rna
disjoint with: RnaRegion
disjoint with: SmallMolecule
disjoint with: TemplateReaction
disjoint with: TemplateReactionRegulation
disjoint with: Transport
disjoint with: TransportWithBiochemicalReaction
comment: An observation-based report of a drug interaction that has been evaluated by some assesssment tool
description: A published and evaluated observation-based ADE report

EV Case Report DI CR Evaluated Data
type: Class
subclass of: EV Case Report DI CR Data
disjoint with: EV Clinical Trial Data
disjoint with: EV EX Met Enz ID CYP450 Data
disjoint with: EV EX Met Enz ID CYP450 Hum Liver Microsome Antibody Data
disjoint with: EV EX Met Enz ID CYP450 Hum Liver Microsome Chem Data
disjoint with: EV EX Met Enz ID CYP450 Hum Liver Microsome Data
disjoint with: EV EX Met Enz ID CYP450 Hum Recom Antibody Data
disjoint with: EV EX Met Enz ID CYP450 Hum Recom Chem Data
disjoint with: EV EX Met Enz ID CYP450 Hum Recom Data
disjoint with: EV EX Met Enz ID Data
disjoint with: EV EX Met Enz Inhibit CYP450 Data
disjoint with: EV EX Met Enz Inhibit CYP450 Human Liver Microsome Data
disjoint with: EV EX Met Enz Inhibit CYP450 Human Recom Data
disjoint with: EV EX Met Enz Inhibit Data
disjoint with: EV Observational Data
disjoint with: EV PK DDI NR Data
disjoint with: EV PK DDI Observational Data
disjoint with: EV PK DDI Par Grps Data
disjoint with: EV PK DDI RCT Data
disjoint with: EV Population PK Data
disjoint with: Enzyme
disjoint with: Increased Drug AUC
disjoint with: Increased Drug Level
disjoint with: Induction
disjoint with: Inhibition
disjoint with: Inhibitor
disjoint with: Journal Peer reviewed
disjoint with: Metabolism
disjoint with: Microsomes
disjoint with: Non randomized Tx Assignment
disjoint with: Observation based DI Report Assessment tool
disjoint with: PK DDI
disjoint with: Pharmacodynamic Effect Consequences
disjoint with: Pharmacokinetic Effect Consequences
disjoint with: Pharmacokinetic Process
disjoint with: Public Reporting Database
disjoint with: Randomized Tx Assignment
disjoint with: Recombinant Protein System
disjoint with: Treatment Assignment
disjoint with: Xenobiotic Metabolism
disjoint with: in vitro Protein Source
disjoint with: BiochemicalReaction
disjoint with: Catalysis
disjoint with: Complex
disjoint with: ComplexAssembly
disjoint with: Control
disjoint with: Conversion
disjoint with: Degradation
disjoint with: Dna
disjoint with: DnaRegion
disjoint with: Entity
disjoint with: Gene
disjoint with: GeneticInteraction
disjoint with: Interaction
disjoint with: Modulation
disjoint with: MolecularInteraction
disjoint with: Pathway
disjoint with: PhysicalEntity
disjoint with: Protein
disjoint with: Rna
disjoint with: RnaRegion
disjoint with: SmallMolecule
disjoint with: TemplateReaction
disjoint with: TemplateReactionRegulation
disjoint with: Transport
disjoint with: TransportWithBiochemicalReaction
description: The data from a published observation-based case-report of a drug interaction that has been evaluated by some assessment tool

EV Case Report DI CR Evaluated Material
type: Class
subclass of: EV Case Report DI CR Material
disjoint with: EV Clinical Trial Material
disjoint with: EV EX Met Enz ID CYP450 Hum Liver Microsome Antibody Material
disjoint with: EV EX Met Enz ID CYP450 Hum Liver Microsome Chem Material
disjoint with: EV EX Met Enz ID CYP450 Hum Liver Microsome Material
disjoint with: EV EX Met Enz ID CYP450 Hum Recom Antibody Material
disjoint with: EV EX Met Enz ID CYP450 Hum Recom Chem Material
disjoint with: EV EX Met Enz ID CYP450 Hum Recom Material
disjoint with: EV EX Met Enz ID CYP450 Material
disjoint with: EV EX Met Enz ID Material
disjoint with: EV EX Met Enz Inhibit CYP450 Human Liver Microsome Material
disjoint with: EV EX Met Enz Inhibit CYP450 Human Recom Material
disjoint with: EV EX Met Enz Inhibit CYP450 Material
disjoint with: EV EX Met Enz Inhibit Material
disjoint with: EV Observational Material
disjoint with: EV PK DDI NR Material
disjoint with: EV PK DDI Observational Material
disjoint with: EV PK DDI Par Grps Material
disjoint with: EV PK DDI RCT Material
disjoint with: EV Population PK Material
disjoint with: Enzyme
disjoint with: Increased Drug AUC
disjoint with: Increased Drug Level
disjoint with: Induction
disjoint with: Inhibition
disjoint with: Inhibitor
disjoint with: Journal Peer reviewed
disjoint with: Metabolism
disjoint with: Microsomes
disjoint with: Non randomized Tx Assignment
disjoint with: Observation based DI Report Assessment tool
disjoint with: PK DDI
disjoint with: Pharmacodynamic Effect Consequences
disjoint with: Pharmacokinetic Effect Consequences
disjoint with: Pharmacokinetic Process
disjoint with: Public Reporting Database
disjoint with: Randomized Tx Assignment
disjoint with: Recombinant Protein System
disjoint with: Treatment Assignment
disjoint with: Xenobiotic Metabolism
disjoint with: in vitro Protein Source
disjoint with: BiochemicalReaction
disjoint with: Catalysis
disjoint with: Complex
disjoint with: ComplexAssembly
disjoint with: Control
disjoint with: Conversion
disjoint with: Degradation
disjoint with: Dna
disjoint with: DnaRegion
disjoint with: Entity
disjoint with: Gene
disjoint with: GeneticInteraction
disjoint with: Interaction
disjoint with: Modulation
disjoint with: MolecularInteraction
disjoint with: Pathway
disjoint with: PhysicalEntity
disjoint with: Protein
disjoint with: Rna
disjoint with: RnaRegion
disjoint with: SmallMolecule
disjoint with: TemplateReaction
disjoint with: TemplateReactionRegulation
disjoint with: Transport
disjoint with: TransportWithBiochemicalReaction
description: The material from a published observation-based case-report of a drug interaction that has been evaluated by some assessment tool

EV Case Report DI CR Material
type: Class
subclass of: EV Case Report ADE Material
disjoint with: EV Clinical Trial Material
disjoint with: EV EX Met Enz ID CYP450 Hum Liver Microsome Antibody Material
disjoint with: EV EX Met Enz ID CYP450 Hum Liver Microsome Chem Material
disjoint with: EV EX Met Enz ID CYP450 Hum Liver Microsome Material
disjoint with: EV EX Met Enz ID CYP450 Hum Recom Antibody Material
disjoint with: EV EX Met Enz ID CYP450 Hum Recom Chem Material
disjoint with: EV EX Met Enz ID CYP450 Hum Recom Material
disjoint with: EV EX Met Enz ID CYP450 Material
disjoint with: EV EX Met Enz ID Material
disjoint with: EV EX Met Enz Inhibit CYP450 Human Liver Microsome Material
disjoint with: EV EX Met Enz Inhibit CYP450 Human Recom Material
disjoint with: EV EX Met Enz Inhibit CYP450 Material
disjoint with: EV EX Met Enz Inhibit Material
disjoint with: EV Observational Material
disjoint with: EV PK DDI NR Material
disjoint with: EV PK DDI Observational Material
disjoint with: EV PK DDI Par Grps Material
disjoint with: EV PK DDI RCT Material
disjoint with: EV Population PK Material
disjoint with: Enzyme
disjoint with: Increased Drug AUC
disjoint with: Increased Drug Level
disjoint with: Induction
disjoint with: Inhibition
disjoint with: Inhibitor
disjoint with: Journal Peer reviewed
disjoint with: Metabolism
disjoint with: Microsomes
disjoint with: Non randomized Tx Assignment
disjoint with: Observation based DI Report Assessment tool
disjoint with: PK DDI
disjoint with: Pharmacodynamic Effect Consequences
disjoint with: Pharmacokinetic Effect Consequences
disjoint with: Pharmacokinetic Process
disjoint with: Public Reporting Database
disjoint with: Randomized Tx Assignment
disjoint with: Recombinant Protein System
disjoint with: Treatment Assignment
disjoint with: Xenobiotic Metabolism
disjoint with: in vitro Protein Source
disjoint with: BiochemicalReaction
disjoint with: Catalysis
disjoint with: Complex
disjoint with: ComplexAssembly
disjoint with: Control
disjoint with: Conversion
disjoint with: Degradation
disjoint with: Dna
disjoint with: DnaRegion
disjoint with: Entity
disjoint with: Gene
disjoint with: GeneticInteraction
disjoint with: Interaction
disjoint with: Modulation
disjoint with: MolecularInteraction
disjoint with: Pathway
disjoint with: PhysicalEntity
disjoint with: Protein
disjoint with: Rna
disjoint with: RnaRegion
disjoint with: SmallMolecule
disjoint with: TemplateReaction
disjoint with: TemplateReactionRegulation
disjoint with: Transport
disjoint with: TransportWithBiochemicalReaction
description: The material from a published observation-based case-report of a drug interaction

EV Case Report Data
type: Class
subclass of: Evidence Type Data
disjoint with: EV Clinical Trial Data
disjoint with: EV EX Met Enz ID CYP450 Data
disjoint with: EV EX Met Enz ID CYP450 Hum Liver Microsome Antibody Data
disjoint with: EV EX Met Enz ID CYP450 Hum Liver Microsome Chem Data
disjoint with: EV EX Met Enz ID CYP450 Hum Liver Microsome Data
disjoint with: EV EX Met Enz ID CYP450 Hum Recom Antibody Data
disjoint with: EV EX Met Enz ID CYP450 Hum Recom Chem Data
disjoint with: EV EX Met Enz ID CYP450 Hum Recom Data
disjoint with: EV EX Met Enz ID Data
disjoint with: EV EX Met Enz Inhibit CYP450 Data
disjoint with: EV EX Met Enz Inhibit CYP450 Human Liver Microsome Data
disjoint with: EV EX Met Enz Inhibit CYP450 Human Recom Data
disjoint with: EV EX Met Enz Inhibit Data
disjoint with: EV Observational Data
disjoint with: EV PK DDI NR Data
disjoint with: EV PK DDI Observational Data
disjoint with: EV PK DDI Par Grps Data
disjoint with: EV PK DDI RCT Data
disjoint with: EV Population PK Data
disjoint with: Enzyme
disjoint with: Increased Drug AUC
disjoint with: Increased Drug Level
disjoint with: Induction
disjoint with: Inhibition
disjoint with: Inhibitor
disjoint with: Journal Peer reviewed
disjoint with: Metabolism
disjoint with: Microsomes
disjoint with: Non randomized Tx Assignment
disjoint with: Observation based DI Report Assessment tool
disjoint with: PK DDI
disjoint with: Pharmacodynamic Effect Consequences
disjoint with: Pharmacokinetic Effect Consequences
disjoint with: Pharmacokinetic Process
disjoint with: Public Reporting Database
disjoint with: Randomized Tx Assignment
disjoint with: Recombinant Protein System
disjoint with: Treatment Assignment
disjoint with: Xenobiotic Metabolism
disjoint with: in vitro Protein Source
disjoint with: BiochemicalReaction
disjoint with: Catalysis
disjoint with: Complex
disjoint with: ComplexAssembly
disjoint with: Control
disjoint with: Conversion
disjoint with: Degradation
disjoint with: Dna
disjoint with: DnaRegion
disjoint with: Entity
disjoint with: Gene
disjoint with: GeneticInteraction
disjoint with: Interaction
disjoint with: Modulation
disjoint with: MolecularInteraction
disjoint with: Pathway
disjoint with: PhysicalEntity
disjoint with: Protein
disjoint with: Rna
disjoint with: RnaRegion
disjoint with: SmallMolecule
disjoint with: TemplateReaction
disjoint with: TemplateReactionRegulation
disjoint with: Transport
disjoint with: TransportWithBiochemicalReaction
description: The data from an observation-based report of some occurrence

EV Case Report Material
type: Class
subclass of: Evidence Type Material
disjoint with: EV Clinical Trial Material
disjoint with: EV EX Met Enz ID CYP450 Hum Liver Microsome Antibody Material
disjoint with: EV EX Met Enz ID CYP450 Hum Liver Microsome Chem Material
disjoint with: EV EX Met Enz ID CYP450 Hum Liver Microsome Material
disjoint with: EV EX Met Enz ID CYP450 Hum Recom Antibody Material
disjoint with: EV EX Met Enz ID CYP450 Hum Recom Chem Material
disjoint with: EV EX Met Enz ID CYP450 Hum Recom Material
disjoint with: EV EX Met Enz ID CYP450 Material
disjoint with: EV EX Met Enz ID Material
disjoint with: EV EX Met Enz Inhibit CYP450 Human Liver Microsome Material
disjoint with: EV EX Met Enz Inhibit CYP450 Human Recom Material
disjoint with: EV EX Met Enz Inhibit CYP450 Material
disjoint with: EV EX Met Enz Inhibit Material
disjoint with: EV Observational Material
disjoint with: EV PK DDI NR Material
disjoint with: EV PK DDI Observational Material
disjoint with: EV PK DDI Par Grps Material
disjoint with: EV PK DDI RCT Material
disjoint with: EV Population PK Material
disjoint with: Enzyme
disjoint with: Increased Drug AUC
disjoint with: Increased Drug Level
disjoint with: Induction
disjoint with: Inhibition
disjoint with: Inhibitor
disjoint with: Journal Peer reviewed
disjoint with: Metabolism
disjoint with: Microsomes
disjoint with: Non randomized Tx Assignment
disjoint with: Observation based DI Report Assessment tool
disjoint with: PK DDI
disjoint with: Pharmacodynamic Effect Consequences
disjoint with: Pharmacokinetic Effect Consequences
disjoint with: Pharmacokinetic Process
disjoint with: Public Reporting Database
disjoint with: Randomized Tx Assignment
disjoint with: Recombinant Protein System
disjoint with: Treatment Assignment
disjoint with: Xenobiotic Metabolism
disjoint with: in vitro Protein Source
disjoint with: BiochemicalReaction
disjoint with: Catalysis
disjoint with: Complex
disjoint with: ComplexAssembly
disjoint with: Control
disjoint with: Conversion
disjoint with: Degradation
disjoint with: Dna
disjoint with: DnaRegion
disjoint with: Entity
disjoint with: Gene
disjoint with: GeneticInteraction
disjoint with: Interaction
disjoint with: Modulation
disjoint with: MolecularInteraction
disjoint with: Pathway
disjoint with: PhysicalEntity
disjoint with: Protein
disjoint with: Rna
disjoint with: RnaRegion
disjoint with: SmallMolecule
disjoint with: TemplateReaction
disjoint with: TemplateReactionRegulation
disjoint with: Transport
disjoint with: TransportWithBiochemicalReaction
description: The material from an observation-based report of some occurrence

EV Clinical Trial
type: Class
equivalent class: Restriction
  on property: has study design
  some values from: clinical trial
subclass of: Evidence Type
subclass of: Restriction
  on property: has participants
  all values from: Clinical Trial Participants
subclass of: Restriction
  on property: has participants
  some values from: Clinical Trial Participants
disjoint with: EV DrugClinicalReview
disjoint with: EV Drug Review
disjoint with: EV EX Met Enz ID
disjoint with: EV EX Met Enz ID CYP450
disjoint with: EV EX Met Enz ID CYP450 Hum Liver Microsome
disjoint with: EV EX Met Enz ID CYP450 Hum Liver Microsome Antibody
disjoint with: EV EX Met Enz ID CYP450 Hum Liver Microsome Chem
disjoint with: EV EX Met Enz ID CYP450 Hum Recom
disjoint with: EV EX Met Enz ID CYP450 Hum Recom Antibody
disjoint with: EV EX Met Enz ID CYP450 Hum Recom Chem
disjoint with: EV EX Met Enz Inhibit
disjoint with: EV EX Met Enz Inhibit CYP450
disjoint with: EV EX Met Enz Inhibit CYP450 Human Liver Microsome
disjoint with: EV EX Met Enz Inhibit CYP450 Human Recom
disjoint with: EV Non Traceable Statement
disjoint with: EV Observational
disjoint with: EV PK DDI Observational
disjoint with: EV Population PK
disjoint with: EV Review
disjoint with: EV Statement
disjoint with: EV Traceable Statement
disjoint with: Enzyme
disjoint with: Increased Drug AUC
disjoint with: Increased Drug Level
disjoint with: Induction
disjoint with: Inhibition
disjoint with: Inhibitor
disjoint with: Journal Peer reviewed
disjoint with: Metabolism
disjoint with: Microsomes
disjoint with: Non randomized Tx Assignment
disjoint with: Observation based DI Report Assessment tool
disjoint with: PK DDI
disjoint with: Pharmacodynamic Effect Consequences
disjoint with: Pharmacokinetic Effect Consequences
disjoint with: Pharmacokinetic Process
disjoint with: Public Reporting Database
disjoint with: Randomized Tx Assignment
disjoint with: Recombinant Protein System
disjoint with: Treatment Assignment
disjoint with: Xenobiotic Metabolism
disjoint with: in vitro Protein Source
disjoint with: BiochemicalReaction
disjoint with: Catalysis
disjoint with: Complex
disjoint with: ComplexAssembly
disjoint with: Control
disjoint with: Conversion
disjoint with: Degradation
disjoint with: Dna
disjoint with: DnaRegion
disjoint with: Entity
disjoint with: Gene
disjoint with: GeneticInteraction
disjoint with: Interaction
disjoint with: Modulation
disjoint with: MolecularInteraction
disjoint with: Pathway
disjoint with: PhysicalEntity
disjoint with: Protein
disjoint with: Rna
disjoint with: RnaRegion
disjoint with: SmallMolecule
disjoint with: TemplateReaction
disjoint with: TemplateReactionRegulation
disjoint with: Transport
disjoint with: TransportWithBiochemicalReaction
comment: "a pre-planned clinical study of the safety, efficacy, or optimum dosage schedule of one or more diagnostic, therapeutic, or prophylactic drugs, devices, or techniques in humans selected according to predetermined criteria of eligibility and observed for predefined evidence of favorable and unfavorable effects." - Clinical Trial MeSH 2007
description: A clinical trial

EV Clinical Trial Data
type: Class
subclass of: Evidence Type Data
disjoint with: EV EX Met Enz ID CYP450 Data
disjoint with: EV EX Met Enz ID CYP450 Hum Liver Microsome Antibody Data
disjoint with: EV EX Met Enz ID CYP450 Hum Liver Microsome Chem Data
disjoint with: EV EX Met Enz ID CYP450 Hum Liver Microsome Data
disjoint with: EV EX Met Enz ID CYP450 Hum Recom Antibody Data
disjoint with: EV EX Met Enz ID CYP450 Hum Recom Chem Data
disjoint with: EV EX Met Enz ID CYP450 Hum Recom Data
disjoint with: EV EX Met Enz ID Data
disjoint with: EV EX Met Enz Inhibit CYP450 Data
disjoint with: EV EX Met Enz Inhibit CYP450 Human Liver Microsome Data
disjoint with: EV EX Met Enz Inhibit CYP450 Human Recom Data
disjoint with: EV EX Met Enz Inhibit Data
disjoint with: EV Observational Data
disjoint with: EV PK DDI Observational Data
disjoint with: EV Population PK Data
disjoint with: Enzyme
disjoint with: Increased Drug AUC
disjoint with: Increased Drug Level
disjoint with: Induction
disjoint with: Inhibition
disjoint with: Inhibitor
disjoint with: Journal Peer reviewed
disjoint with: Metabolism
disjoint with: Microsomes
disjoint with: Non randomized Tx Assignment
disjoint with: Observation based DI Report Assessment tool
disjoint with: PK DDI
disjoint with: Pharmacodynamic Effect Consequences
disjoint with: Pharmacokinetic Effect Consequences
disjoint with: Pharmacokinetic Process
disjoint with: Public Reporting Database
disjoint with: Randomized Tx Assignment
disjoint with: Recombinant Protein System
disjoint with: Treatment Assignment
disjoint with: Xenobiotic Metabolism
disjoint with: in vitro Protein Source
disjoint with: BiochemicalReaction
disjoint with: Catalysis
disjoint with: Complex
disjoint with: ComplexAssembly
disjoint with: Control
disjoint with: Conversion
disjoint with: Degradation
disjoint with: Dna
disjoint with: DnaRegion
disjoint with: Entity
disjoint with: Gene
disjoint with: GeneticInteraction
disjoint with: Interaction
disjoint with: Modulation
disjoint with: MolecularInteraction
disjoint with: Pathway
disjoint with: PhysicalEntity
disjoint with: Protein
disjoint with: Rna
disjoint with: RnaRegion
disjoint with: SmallMolecule
disjoint with: TemplateReaction
disjoint with: TemplateReactionRegulation
disjoint with: Transport
disjoint with: TransportWithBiochemicalReaction
description: Data from a clinical trial, where a clinical trial is a: "a pre-planned clinical study of the safety, efficacy, or optimum dosage schedule of one or more diagnostic, therapeutic, or prophylactic drugs, devices, or techniques in humans selected according to predetermined criteria of eligibility and observed for predefined evidence of favorable and unfavorable effects." - Clinical Trial MeSH 2007

EV Clinical Trial Material
type: Class
subclass of: Evidence Type Material
disjoint with: EV EX Met Enz ID CYP450 Hum Liver Microsome Antibody Material
disjoint with: EV EX Met Enz ID CYP450 Hum Liver Microsome Chem Material
disjoint with: EV EX Met Enz ID CYP450 Hum Liver Microsome Material
disjoint with: EV EX Met Enz ID CYP450 Hum Recom Antibody Material
disjoint with: EV EX Met Enz ID CYP450 Hum Recom Chem Material
disjoint with: EV EX Met Enz ID CYP450 Hum Recom Material
disjoint with: EV EX Met Enz ID CYP450 Material
disjoint with: EV EX Met Enz ID Material
disjoint with: EV EX Met Enz Inhibit CYP450 Human Liver Microsome Material
disjoint with: EV EX Met Enz Inhibit CYP450 Human Recom Material
disjoint with: EV EX Met Enz Inhibit CYP450 Material
disjoint with: EV EX Met Enz Inhibit Material
disjoint with: EV Observational Material
disjoint with: EV PK DDI Observational Material
disjoint with: EV Population PK Material
disjoint with: Enzyme
disjoint with: Increased Drug AUC
disjoint with: Increased Drug Level
disjoint with: Induction
disjoint with: Inhibition
disjoint with: Inhibitor
disjoint with: Journal Peer reviewed
disjoint with: Metabolism
disjoint with: Microsomes
disjoint with: Non randomized Tx Assignment
disjoint with: Observation based DI Report Assessment tool
disjoint with: PK DDI
disjoint with: Pharmacodynamic Effect Consequences
disjoint with: Pharmacokinetic Effect Consequences
disjoint with: Pharmacokinetic Process
disjoint with: Public Reporting Database
disjoint with: Randomized Tx Assignment
disjoint with: Recombinant Protein System
disjoint with: Treatment Assignment
disjoint with: Xenobiotic Metabolism
disjoint with: in vitro Protein Source
disjoint with: BiochemicalReaction
disjoint with: Catalysis
disjoint with: Complex
disjoint with: ComplexAssembly
disjoint with: Control
disjoint with: Conversion
disjoint with: Degradation
disjoint with: Dna
disjoint with: DnaRegion
disjoint with: Entity
disjoint with: Gene
disjoint with: GeneticInteraction
disjoint with: Interaction
disjoint with: Modulation
disjoint with: MolecularInteraction
disjoint with: Pathway
disjoint with: PhysicalEntity
disjoint with: Protein
disjoint with: Rna
disjoint with: RnaRegion
disjoint with: SmallMolecule
disjoint with: TemplateReaction
disjoint with: TemplateReactionRegulation
disjoint with: Transport
disjoint with: TransportWithBiochemicalReaction
description: Material from a clinical trial, where a clinical trial is a: "a pre-planned clinical study of the safety, efficacy, or optimum dosage schedule of one or more diagnostic, therapeutic, or prophylactic drugs, devices, or techniques in humans selected according to predetermined criteria of eligibility and observed for predefined evidence of favorable and unfavorable effects." - Clinical Trial MeSH 2007

EV DrugClinicalReview
type: Class
subclass of: EV Drug Review
subclass of: Restriction
  on property: has sponser
  has value: US Food and Drug Administration
disjoint with: EV Non Traceable Statement
disjoint with: EV Observational
disjoint with: EV PK DDI NR
disjoint with: EV PK DDI Observational
disjoint with: EV PK DDI Par Grps
disjoint with: EV PK DDI RCT
disjoint with: EV Population PK
disjoint with: EV Statement
disjoint with: EV Traceable Statement
disjoint with: Enzyme
disjoint with: Increased Drug AUC
disjoint with: Increased Drug Level
disjoint with: Induction
disjoint with: Inhibition
disjoint with: Inhibitor
disjoint with: Journal Peer reviewed
disjoint with: Metabolism
disjoint with: Microsomes
disjoint with: Non randomized Tx Assignment
disjoint with: Observation based DI Report Assessment tool
disjoint with: PK DDI
disjoint with: Pharmacodynamic Effect Consequences
disjoint with: Pharmacokinetic Effect Consequences
disjoint with: Pharmacokinetic Process
disjoint with: Public Reporting Database
disjoint with: Randomized Tx Assignment
disjoint with: Recombinant Protein System
disjoint with: Treatment Assignment
disjoint with: Xenobiotic Metabolism
disjoint with: in vitro Protein Source
disjoint with: BiochemicalReaction
disjoint with: Catalysis
disjoint with: Complex
disjoint with: ComplexAssembly
disjoint with: Control
disjoint with: Conversion
disjoint with: Degradation
disjoint with: Dna
disjoint with: DnaRegion
disjoint with: Entity
disjoint with: Gene
disjoint with: GeneticInteraction
disjoint with: Interaction
disjoint with: Modulation
disjoint with: MolecularInteraction
disjoint with: Pathway
disjoint with: PhysicalEntity
disjoint with: Protein
disjoint with: Rna
disjoint with: RnaRegion
disjoint with: SmallMolecule
disjoint with: TemplateReaction
disjoint with: TemplateReactionRegulation
disjoint with: Transport
disjoint with: TransportWithBiochemicalReaction
comment: An FDA-sponsered review of a drug's pre-market studies and adverse event reports.
description: An FDA clinical review

EV Drug Review
type: Class
equivalent class: Class
  intersection of: EV Review
  intersection of: Restriction
    on property: is published in
    some values from: Journal Peer reviewed
  intersection of: Restriction
    on property: references
    some values from: Evidence Type
  intersection of: Restriction
    on property: summarizes research on topic
    some values from: Drug
  intersection of: Restriction
    on property: is published in
    all values from: Journal Peer reviewed
  intersection of: Restriction
    on property: references
    all values from: Evidence Type
  intersection of: Restriction
    on property: summarizes research on topic
    all values from: Drug
subclass of: EV Review
disjoint with: EV Non Traceable Statement
disjoint with: EV Observational
disjoint with: EV PK DDI NR
disjoint with: EV PK DDI Observational
disjoint with: EV PK DDI Par Grps
disjoint with: EV PK DDI RCT
disjoint with: EV Population PK
disjoint with: EV Statement
disjoint with: EV Traceable Statement
disjoint with: Enzyme
disjoint with: Increased Drug AUC
disjoint with: Increased Drug Level
disjoint with: Induction
disjoint with: Inhibition
disjoint with: Inhibitor
disjoint with: Journal Peer reviewed
disjoint with: Metabolism
disjoint with: Microsomes
disjoint with: Non randomized Tx Assignment
disjoint with: Observation based DI Report Assessment tool
disjoint with: PK DDI
disjoint with: Pharmacodynamic Effect Consequences
disjoint with: Pharmacokinetic Effect Consequences
disjoint with: Pharmacokinetic Process
disjoint with: Public Reporting Database
disjoint with: Randomized Tx Assignment
disjoint with: Recombinant Protein System
disjoint with: Treatment Assignment
disjoint with: Xenobiotic Metabolism
disjoint with: in vitro Protein Source
disjoint with: BiochemicalReaction
disjoint with: Catalysis
disjoint with: Complex
disjoint with: ComplexAssembly
disjoint with: Control
disjoint with: Conversion
disjoint with: Degradation
disjoint with: Dna
disjoint with: DnaRegion
disjoint with: Entity
disjoint with: Gene
disjoint with: GeneticInteraction
disjoint with: Interaction
disjoint with: Modulation
disjoint with: MolecularInteraction
disjoint with: Pathway
disjoint with: PhysicalEntity
disjoint with: Protein
disjoint with: Rna
disjoint with: RnaRegion
disjoint with: SmallMolecule
disjoint with: TemplateReaction
disjoint with: TemplateReactionRegulation
disjoint with: Transport
disjoint with: TransportWithBiochemicalReaction
comment: A published analysis of research on the efficacy or safety of a drug, family of drugs, or drug therapy
description: A drug review article

EV EX Met Enz ID
type: Class
equivalent class: Class
  intersection of: Evidence Type
  intersection of: Restriction
    on property: has focus of inquiry
    some values from: Drug Metabolism
  intersection of: Restriction
    on property: has study design
    some values from: in vitro study
  intersection of: Restriction
    on property: investigates drug
    some values from: Drug
  intersection of: Restriction
    on property: source of experimental protein
    some values from: in vitro Protein Source
  intersection of: Restriction
    on property: tests if drug is substrate of
    some values from: Enzyme
  intersection of: Restriction
    on property: has focus of inquiry
    all values from: Drug Metabolism
  intersection of: Restriction
    on property: investigates drug
    all values from: Drug
  intersection of: Restriction
    on property: source of experimental protein
    all values from: in vitro Protein Source
  intersection of: Restriction
    on property: tests if drug is substrate of
    all values from: Enzyme
subclass of: Evidence Type
disjoint with: EV EX Met Enz Inhibit
disjoint with: EV EX Met Enz Inhibit CYP450
disjoint with: EV EX Met Enz Inhibit CYP450 Human Liver Microsome
disjoint with: EV EX Met Enz Inhibit CYP450 Human Recom
disjoint with: EV Non Traceable Statement
disjoint with: EV Observational
disjoint with: EV PK DDI NR
disjoint with: EV PK DDI Observational
disjoint with: EV PK DDI Par Grps
disjoint with: EV PK DDI RCT
disjoint with: EV Population PK
disjoint with: EV Statement
disjoint with: EV Traceable Statement
disjoint with: Enzyme
disjoint with: Increased Drug AUC
disjoint with: Increased Drug Level
disjoint with: Induction
disjoint with: Inhibition
disjoint with: Inhibitor
disjoint with: Journal Peer reviewed
disjoint with: Metabolism
disjoint with: Microsomes
disjoint with: Non randomized Tx Assignment
disjoint with: Observation based DI Report Assessment tool
disjoint with: PK DDI
disjoint with: Pharmacodynamic Effect Consequences
disjoint with: Pharmacokinetic Effect Consequences
disjoint with: Pharmacokinetic Process
disjoint with: Public Reporting Database
disjoint with: Randomized Tx Assignment
disjoint with: Recombinant Protein System
disjoint with: Treatment Assignment
disjoint with: Xenobiotic Metabolism
disjoint with: in vitro Protein Source
disjoint with: BiochemicalReaction
disjoint with: Catalysis
disjoint with: Complex
disjoint with: ComplexAssembly
disjoint with: Control
disjoint with: Conversion
disjoint with: Degradation
disjoint with: Dna
disjoint with: DnaRegion
disjoint with: Entity
disjoint with: Gene
disjoint with: GeneticInteraction
disjoint with: Interaction
disjoint with: Modulation
disjoint with: MolecularInteraction
disjoint with: Pathway
disjoint with: PhysicalEntity
disjoint with: Protein
disjoint with: Rna
disjoint with: RnaRegion
disjoint with: SmallMolecule
disjoint with: TemplateReaction
disjoint with: TemplateReactionRegulation
disjoint with: Transport
disjoint with: TransportWithBiochemicalReaction
comment: A drug metabolism identification experiment -- an experiment conducted with biological tissues and/or chemical compounds in a laboratory designed to ``...identify the specific enzymes responsible for the metabolism of a drug'' (\cite{fda2006a}, p. 25)
description: A drug metabolism identification experiment

EV EX Met Enz ID CYP450
type: Class
equivalent class: Class
  intersection of: EV EX Met Enz ID
  intersection of: Restriction
    on property: tests if drug is substrate of
    some values from: Cytochrome P450
  intersection of: Restriction
    on property: tests if drug is substrate of
    all values from: Cytochrome P450
subclass of: EV EX Met Enz ID
disjoint with: EV EX Met Enz Inhibit
disjoint with: EV EX Met Enz Inhibit CYP450
disjoint with: EV EX Met Enz Inhibit CYP450 Human Liver Microsome
disjoint with: EV EX Met Enz Inhibit CYP450 Human Recom
disjoint with: EV Non Traceable Statement
disjoint with: EV Observational
disjoint with: EV PK DDI NR
disjoint with: EV PK DDI Observational
disjoint with: EV PK DDI Par Grps
disjoint with: EV PK DDI RCT
disjoint with: EV Population PK
disjoint with: EV Statement
disjoint with: EV Traceable Statement
disjoint with: Enzyme
disjoint with: Increased Drug AUC
disjoint with: Increased Drug Level
disjoint with: Induction
disjoint with: Inhibition
disjoint with: Inhibitor
disjoint with: Journal Peer reviewed
disjoint with: Metabolism
disjoint with: Microsomes
disjoint with: Non randomized Tx Assignment
disjoint with: Observation based DI Report Assessment tool
disjoint with: PK DDI
disjoint with: Pharmacodynamic Effect Consequences
disjoint with: Pharmacokinetic Effect Consequences
disjoint with: Pharmacokinetic Process
disjoint with: Public Reporting Database
disjoint with: Randomized Tx Assignment
disjoint with: Recombinant Protein System
disjoint with: Treatment Assignment
disjoint with: Xenobiotic Metabolism
disjoint with: in vitro Protein Source
disjoint with: BiochemicalReaction
disjoint with: Catalysis
disjoint with: Complex
disjoint with: ComplexAssembly
disjoint with: Control
disjoint with: Conversion
disjoint with: Degradation
disjoint with: Dna
disjoint with: DnaRegion
disjoint with: Entity
disjoint with: Gene
disjoint with: GeneticInteraction
disjoint with: Interaction
disjoint with: Modulation
disjoint with: MolecularInteraction
disjoint with: Pathway
disjoint with: PhysicalEntity
disjoint with: Protein
disjoint with: Rna
disjoint with: RnaRegion
disjoint with: SmallMolecule
disjoint with: TemplateReaction
disjoint with: TemplateReactionRegulation
disjoint with: Transport
disjoint with: TransportWithBiochemicalReaction
comment: A metabolic enzyme identification experiment specifically designed to identify the Cytochrome P-450 enzymes involved in the metabolism of a drug
description: A CYP450 drug metabolism identification experiment

EV EX Met Enz ID CYP450 Data
type: Class
subclass of: EV EX Met Enz ID Data
disjoint with: EV EX Met Enz Inhibit CYP450 Data
disjoint with: EV EX Met Enz Inhibit CYP450 Human Liver Microsome Data
disjoint with: EV EX Met Enz Inhibit CYP450 Human Recom Data
disjoint with: EV EX Met Enz Inhibit Data
disjoint with: EV Observational Data
disjoint with: EV PK DDI NR Data
disjoint with: EV PK DDI Observational Data
disjoint with: EV PK DDI Par Grps Data
disjoint with: EV PK DDI RCT Data
disjoint with: EV Population PK Data
disjoint with: Enzyme
disjoint with: Increased Drug AUC
disjoint with: Increased Drug Level
disjoint with: Induction
disjoint with: Inhibition
disjoint with: Inhibitor
disjoint with: Journal Peer reviewed
disjoint with: Metabolism
disjoint with: Microsomes
disjoint with: Non randomized Tx Assignment
disjoint with: Observation based DI Report Assessment tool
disjoint with: PK DDI
disjoint with: Pharmacodynamic Effect Consequences
disjoint with: Pharmacokinetic Effect Consequences
disjoint with: Pharmacokinetic Process
disjoint with: Public Reporting Database
disjoint with: Randomized Tx Assignment
disjoint with: Recombinant Protein System
disjoint with: Treatment Assignment
disjoint with: Xenobiotic Metabolism
disjoint with: in vitro Protein Source
disjoint with: BiochemicalReaction
disjoint with: Catalysis
disjoint with: Complex
disjoint with: ComplexAssembly
disjoint with: Control
disjoint with: Conversion
disjoint with: Degradation
disjoint with: Dna
disjoint with: DnaRegion
disjoint with: Entity
disjoint with: Gene
disjoint with: GeneticInteraction
disjoint with: Interaction
disjoint with: Modulation
disjoint with: MolecularInteraction
disjoint with: Pathway
disjoint with: PhysicalEntity
disjoint with: Protein
disjoint with: Rna
disjoint with: RnaRegion
disjoint with: SmallMolecule
disjoint with: TemplateReaction
disjoint with: TemplateReactionRegulation
disjoint with: Transport
disjoint with: TransportWithBiochemicalReaction
description: Data from a metabolic enzyme identification experiment specifically designed to identify the Cytochrome P-450 enzymes involved in the metabolism of a drug

EV EX Met Enz ID CYP450 Hum Liver Microsome
type: Class
equivalent class: Class
  intersection of: EV EX Met Enz ID CYP450
  intersection of: Restriction
    on property: source of experimental protein
    has value: human liver microsomes
subclass of: EV EX Met Enz ID CYP450
disjoint with: EV EX Met Enz Inhibit
disjoint with: EV EX Met Enz Inhibit CYP450
disjoint with: EV EX Met Enz Inhibit CYP450 Human Liver Microsome
disjoint with: EV EX Met Enz Inhibit CYP450 Human Recom
disjoint with: EV Non Traceable Statement
disjoint with: EV Observational
disjoint with: EV PK DDI NR
disjoint with: EV PK DDI Observational
disjoint with: EV PK DDI Par Grps
disjoint with: EV PK DDI RCT
disjoint with: EV Population PK
disjoint with: EV Statement
disjoint with: EV Traceable Statement
disjoint with: Enzyme
disjoint with: Increased Drug AUC
disjoint with: Increased Drug Level
disjoint with: Induction
disjoint with: Inhibition
disjoint with: Inhibitor
disjoint with: Journal Peer reviewed
disjoint with: Metabolism
disjoint with: Microsomes
disjoint with: Non randomized Tx Assignment
disjoint with: Observation based DI Report Assessment tool
disjoint with: PK DDI
disjoint with: Pharmacodynamic Effect Consequences
disjoint with: Pharmacokinetic Effect Consequences
disjoint with: Pharmacokinetic Process
disjoint with: Public Reporting Database
disjoint with: Randomized Tx Assignment
disjoint with: Recombinant Protein System
disjoint with: Treatment Assignment
disjoint with: Xenobiotic Metabolism
disjoint with: in vitro Protein Source
disjoint with: BiochemicalReaction
disjoint with: Catalysis
disjoint with: Complex
disjoint with: ComplexAssembly
disjoint with: Control
disjoint with: Conversion
disjoint with: Degradation
disjoint with: Dna
disjoint with: DnaRegion
disjoint with: Entity
disjoint with: Gene
disjoint with: GeneticInteraction
disjoint with: Interaction
disjoint with: Modulation
disjoint with: MolecularInteraction
disjoint with: Pathway
disjoint with: PhysicalEntity
disjoint with: Protein
disjoint with: Rna
disjoint with: RnaRegion
disjoint with: SmallMolecule
disjoint with: TemplateReaction
disjoint with: TemplateReactionRegulation
disjoint with: Transport
disjoint with: TransportWithBiochemicalReaction
comment: A Cytochrome P-450 metabolic enzyme identification experiment using human liver microsomes that have been characterized for Cytochrome P-450 activity
description: A CYP450, human microsome, drug metabolism identification experiment

EV EX Met Enz ID CYP450 Hum Liver Microsome Antibody
type: Class
equivalent class: Class
  intersection of: EV EX Met Enz ID CYP450 Hum Liver Microsome
  intersection of: Restriction
    on property: uses inhibitor of enzyme
    some values from: Antibody Inhibitor
  intersection of: Restriction
    on property: uses inhibitor of enzyme
    all values from: Antibody Inhibitor
subclass of: EV EX Met Enz ID CYP450 Hum Liver Microsome
disjoint with: EV EX Met Enz ID CYP450 Hum Liver Microsome Chem
disjoint with: EV EX Met Enz ID CYP450 Hum Recom Chem
disjoint with: EV EX Met Enz Inhibit
disjoint with: EV EX Met Enz Inhibit CYP450
disjoint with: EV EX Met Enz Inhibit CYP450 Human Liver Microsome
disjoint with: EV EX Met Enz Inhibit CYP450 Human Recom
disjoint with: EV Non Traceable Statement
disjoint with: EV Observational
disjoint with: EV PK DDI NR
disjoint with: EV PK DDI Observational
disjoint with: EV PK DDI Par Grps
disjoint with: EV PK DDI RCT
disjoint with: EV Population PK
disjoint with: EV Statement
disjoint with: EV Traceable Statement
disjoint with: Enzyme
disjoint with: Increased Drug AUC
disjoint with: Increased Drug Level
disjoint with: Induction
disjoint with: Inhibition
disjoint with: Inhibitor
disjoint with: Journal Peer reviewed
disjoint with: Metabolism
disjoint with: Microsomes
disjoint with: Non randomized Tx Assignment
disjoint with: Observation based DI Report Assessment tool
disjoint with: PK DDI
disjoint with: Pharmacodynamic Effect Consequences
disjoint with: Pharmacokinetic Effect Consequences
disjoint with: Pharmacokinetic Process
disjoint with: Public Reporting Database
disjoint with: Randomized Tx Assignment
disjoint with: Recombinant Protein System
disjoint with: Treatment Assignment
disjoint with: Xenobiotic Metabolism
disjoint with: in vitro Protein Source
disjoint with: BiochemicalReaction
disjoint with: Catalysis
disjoint with: Complex
disjoint with: ComplexAssembly
disjoint with: Control
disjoint with: Conversion
disjoint with: Degradation
disjoint with: Dna
disjoint with: DnaRegion
disjoint with: Entity
disjoint with: Gene
disjoint with: GeneticInteraction
disjoint with: Interaction
disjoint with: Modulation
disjoint with: MolecularInteraction
disjoint with: Pathway
disjoint with: PhysicalEntity
disjoint with: Protein
disjoint with: Rna
disjoint with: RnaRegion
disjoint with: SmallMolecule
disjoint with: TemplateReaction
disjoint with: TemplateReactionRegulation
disjoint with: Transport
disjoint with: TransportWithBiochemicalReaction
comment: A Cytochrome P-450 metabolic enzyme identification experiment using human liver microsomes that have been characterized for Cytochrome P-450 activity and antibodies as specific inhibitors
description: A CYP450, human microsome, drug metabolism identification experiment using antibody inhibitors

EV EX Met Enz ID CYP450 Hum Liver Microsome Antibody Data
type: Class
subclass of: EV EX Met Enz ID CYP450 Hum Liver Microsome Data
disjoint with: EV EX Met Enz Inhibit CYP450 Data
disjoint with: EV EX Met Enz Inhibit CYP450 Human Liver Microsome Data
disjoint with: EV EX Met Enz Inhibit CYP450 Human Recom Data
disjoint with: EV EX Met Enz Inhibit Data
disjoint with: EV Observational Data
disjoint with: EV PK DDI NR Data
disjoint with: EV PK DDI Observational Data
disjoint with: EV PK DDI Par Grps Data
disjoint with: EV PK DDI RCT Data
disjoint with: EV Population PK Data
disjoint with: Enzyme
disjoint with: Increased Drug AUC
disjoint with: Increased Drug Level
disjoint with: Induction
disjoint with: Inhibition
disjoint with: Inhibitor
disjoint with: Journal Peer reviewed
disjoint with: Metabolism
disjoint with: Microsomes
disjoint with: Non randomized Tx Assignment
disjoint with: Observation based DI Report Assessment tool
disjoint with: PK DDI
disjoint with: Pharmacodynamic Effect Consequences
disjoint with: Pharmacokinetic Effect Consequences
disjoint with: Pharmacokinetic Process
disjoint with: Public Reporting Database
disjoint with: Randomized Tx Assignment
disjoint with: Recombinant Protein System
disjoint with: Treatment Assignment
disjoint with: Xenobiotic Metabolism
disjoint with: in vitro Protein Source
disjoint with: BiochemicalReaction
disjoint with: Catalysis
disjoint with: Complex
disjoint with: ComplexAssembly
disjoint with: Control
disjoint with: Conversion
disjoint with: Degradation
disjoint with: Dna
disjoint with: DnaRegion
disjoint with: Entity
disjoint with: Gene
disjoint with: GeneticInteraction
disjoint with: Interaction
disjoint with: Modulation
disjoint with: MolecularInteraction
disjoint with: Pathway
disjoint with: PhysicalEntity
disjoint with: Protein
disjoint with: Rna
disjoint with: RnaRegion
disjoint with: SmallMolecule
disjoint with: TemplateReaction
disjoint with: TemplateReactionRegulation
disjoint with: Transport
disjoint with: TransportWithBiochemicalReaction
description: Data from a Cytochrome P-450 metabolic enzyme identification experiment using human liver microsomes that have been characterized for Cytochrome P-450 activity and antibodies as specific inhibitors

EV EX Met Enz ID CYP450 Hum Liver Microsome Antibody Material
type: Class
subclass of: EV EX Met Enz ID CYP450 Hum Liver Microsome Material
disjoint with: EV EX Met Enz Inhibit CYP450 Human Liver Microsome Material
disjoint with: EV EX Met Enz Inhibit CYP450 Human Recom Material
disjoint with: EV EX Met Enz Inhibit CYP450 Material
disjoint with: EV EX Met Enz Inhibit Material
disjoint with: EV Observational Material
disjoint with: EV PK DDI NR Material
disjoint with: EV PK DDI Observational Material
disjoint with: EV PK DDI Par Grps Material
disjoint with: EV PK DDI RCT Material
disjoint with: EV Population PK Material
disjoint with: Enzyme
disjoint with: Increased Drug AUC
disjoint with: Increased Drug Level
disjoint with: Induction
disjoint with: Inhibition
disjoint with: Inhibitor
disjoint with: Journal Peer reviewed
disjoint with: Metabolism
disjoint with: Microsomes
disjoint with: Non randomized Tx Assignment
disjoint with: Observation based DI Report Assessment tool
disjoint with: PK DDI
disjoint with: Pharmacodynamic Effect Consequences
disjoint with: Pharmacokinetic Effect Consequences
disjoint with: Pharmacokinetic Process
disjoint with: Public Reporting Database
disjoint with: Randomized Tx Assignment
disjoint with: Recombinant Protein System
disjoint with: Treatment Assignment
disjoint with: Xenobiotic Metabolism
disjoint with: in vitro Protein Source
disjoint with: BiochemicalReaction
disjoint with: Catalysis
disjoint with: Complex
disjoint with: ComplexAssembly
disjoint with: Control
disjoint with: Conversion
disjoint with: Degradation
disjoint with: Dna
disjoint with: DnaRegion
disjoint with: Entity
disjoint with: Gene
disjoint with: GeneticInteraction
disjoint with: Interaction
disjoint with: Modulation
disjoint with: MolecularInteraction
disjoint with: Pathway
disjoint with: PhysicalEntity
disjoint with: Protein
disjoint with: Rna
disjoint with: RnaRegion
disjoint with: SmallMolecule
disjoint with: TemplateReaction
disjoint with: TemplateReactionRegulation
disjoint with: Transport
disjoint with: TransportWithBiochemicalReaction
description: Material from a Cytochrome P-450 metabolic enzyme identification experiment using human liver microsomes that have been characterized for Cytochrome P-450 activity and antibodies as specific inhibitors

EV EX Met Enz ID CYP450 Hum Liver Microsome Chem
type: Class
equivalent class: Class
  intersection of: EV EX Met Enz ID CYP450 Hum Liver Microsome
  intersection of: Restriction
    on property: uses inhibitor of enzyme
    some values from: Chemical Inhibitor
  intersection of: Restriction
    on property: uses inhibitor of enzyme
    all values from: Chemical Inhibitor
subclass of: EV EX Met Enz ID CYP450 Hum Liver Microsome
disjoint with: EV EX Met Enz ID CYP450 Hum Recom Antibody
disjoint with: EV EX Met Enz Inhibit
disjoint with: EV EX Met Enz Inhibit CYP450
disjoint with: EV EX Met Enz Inhibit CYP450 Human Liver Microsome
disjoint with: EV EX Met Enz Inhibit CYP450 Human Recom
disjoint with: EV Non Traceable Statement
disjoint with: EV Observational
disjoint with: EV PK DDI NR
disjoint with: EV PK DDI Observational
disjoint with: EV PK DDI Par Grps
disjoint with: EV PK DDI RCT
disjoint with: EV Population PK
disjoint with: EV Statement
disjoint with: EV Traceable Statement
disjoint with: Enzyme
disjoint with: Increased Drug AUC
disjoint with: Increased Drug Level
disjoint with: Induction
disjoint with: Inhibition
disjoint with: Inhibitor
disjoint with: Journal Peer reviewed
disjoint with: Metabolism
disjoint with: Microsomes
disjoint with: Non randomized Tx Assignment
disjoint with: Observation based DI Report Assessment tool
disjoint with: PK DDI
disjoint with: Pharmacodynamic Effect Consequences
disjoint with: Pharmacokinetic Effect Consequences
disjoint with: Pharmacokinetic Process
disjoint with: Public Reporting Database
disjoint with: Randomized Tx Assignment
disjoint with: Recombinant Protein System
disjoint with: Treatment Assignment
disjoint with: Xenobiotic Metabolism
disjoint with: in vitro Protein Source
disjoint with: BiochemicalReaction
disjoint with: Catalysis
disjoint with: Complex
disjoint with: ComplexAssembly
disjoint with: Control
disjoint with: Conversion
disjoint with: Degradation
disjoint with: Dna
disjoint with: DnaRegion
disjoint with: Entity
disjoint with: Gene
disjoint with: GeneticInteraction
disjoint with: Interaction
disjoint with: Modulation
disjoint with: MolecularInteraction
disjoint with: Pathway
disjoint with: PhysicalEntity
disjoint with: Protein
disjoint with: Rna
disjoint with: RnaRegion
disjoint with: SmallMolecule
disjoint with: TemplateReaction
disjoint with: TemplateReactionRegulation
disjoint with: Transport
disjoint with: TransportWithBiochemicalReaction
comment: A Cytochrome P-450 metabolic enzyme identification experiment using human liver microsomes that have been characterized for Cytochrome P-450 activity and chemical inhibitors
description: A CYP450, human microsome, drug metabolism identification experiment using chemical inhibitors

EV EX Met Enz ID CYP450 Hum Liver Microsome Chem Data
type: Class
subclass of: EV EX Met Enz ID CYP450 Hum Liver Microsome Data
disjoint with: EV EX Met Enz Inhibit CYP450 Data
disjoint with: EV EX Met Enz Inhibit CYP450 Human Liver Microsome Data
disjoint with: EV EX Met Enz Inhibit CYP450 Human Recom Data
disjoint with: EV EX Met Enz Inhibit Data
disjoint with: EV Observational Data
disjoint with: EV PK DDI NR Data
disjoint with: EV PK DDI Observational Data
disjoint with: EV PK DDI Par Grps Data
disjoint with: EV PK DDI RCT Data
disjoint with: EV Population PK Data
disjoint with: Enzyme
disjoint with: Increased Drug AUC
disjoint with: Increased Drug Level
disjoint with: Induction
disjoint with: Inhibition
disjoint with: Inhibitor
disjoint with: Journal Peer reviewed
disjoint with: Metabolism
disjoint with: Microsomes
disjoint with: Non randomized Tx Assignment
disjoint with: Observation based DI Report Assessment tool
disjoint with: PK DDI
disjoint with: Pharmacodynamic Effect Consequences
disjoint with: Pharmacokinetic Effect Consequences
disjoint with: Pharmacokinetic Process
disjoint with: Public Reporting Database
disjoint with: Randomized Tx Assignment
disjoint with: Recombinant Protein System
disjoint with: Treatment Assignment
disjoint with: Xenobiotic Metabolism
disjoint with: in vitro Protein Source
disjoint with: BiochemicalReaction
disjoint with: Catalysis
disjoint with: Complex
disjoint with: ComplexAssembly
disjoint with: Control
disjoint with: Conversion
disjoint with: Degradation
disjoint with: Dna
disjoint with: DnaRegion
disjoint with: Entity
disjoint with: Gene
disjoint with: GeneticInteraction
disjoint with: Interaction
disjoint with: Modulation
disjoint with: MolecularInteraction
disjoint with: Pathway
disjoint with: PhysicalEntity
disjoint with: Protein
disjoint with: Rna
disjoint with: RnaRegion
disjoint with: SmallMolecule
disjoint with: TemplateReaction
disjoint with: TemplateReactionRegulation
disjoint with: Transport
disjoint with: TransportWithBiochemicalReaction
description: Data from a Cytochrome P-450 metabolic enzyme identification experiment using human liver microsomes that have been characterized for Cytochrome P-450 activity and chemical inhibitors

EV EX Met Enz ID CYP450 Hum Liver Microsome Chem Material
type: Class
subclass of: EV EX Met Enz ID CYP450 Hum Liver Microsome Material
disjoint with: EV EX Met Enz Inhibit CYP450 Human Liver Microsome Material
disjoint with: EV EX Met Enz Inhibit CYP450 Human Recom Material
disjoint with: EV EX Met Enz Inhibit CYP450 Material
disjoint with: EV EX Met Enz Inhibit Material
disjoint with: EV Observational Material
disjoint with: EV PK DDI NR Material
disjoint with: EV PK DDI Observational Material
disjoint with: EV PK DDI Par Grps Material
disjoint with: EV PK DDI RCT Material
disjoint with: EV Population PK Material
disjoint with: Enzyme
disjoint with: Increased Drug AUC
disjoint with: Increased Drug Level
disjoint with: Induction
disjoint with: Inhibition
disjoint with: Inhibitor
disjoint with: Journal Peer reviewed
disjoint with: Metabolism
disjoint with: Microsomes
disjoint with: Non randomized Tx Assignment
disjoint with: Observation based DI Report Assessment tool
disjoint with: PK DDI
disjoint with: Pharmacodynamic Effect Consequences
disjoint with: Pharmacokinetic Effect Consequences
disjoint with: Pharmacokinetic Process
disjoint with: Public Reporting Database
disjoint with: Randomized Tx Assignment
disjoint with: Recombinant Protein System
disjoint with: Treatment Assignment
disjoint with: Xenobiotic Metabolism
disjoint with: in vitro Protein Source
disjoint with: BiochemicalReaction
disjoint with: Catalysis
disjoint with: Complex
disjoint with: ComplexAssembly
disjoint with: Control
disjoint with: Conversion
disjoint with: Degradation
disjoint with: Dna
disjoint with: DnaRegion
disjoint with: Entity
disjoint with: Gene
disjoint with: GeneticInteraction
disjoint with: Interaction
disjoint with: Modulation
disjoint with: MolecularInteraction
disjoint with: Pathway
disjoint with: PhysicalEntity
disjoint with: Protein
disjoint with: Rna
disjoint with: RnaRegion
disjoint with: SmallMolecule
disjoint with: TemplateReaction
disjoint with: TemplateReactionRegulation
disjoint with: Transport
disjoint with: TransportWithBiochemicalReaction
description: Material from a Cytochrome P-450 metabolic enzyme identification experiment using human liver microsomes that have been characterized for Cytochrome P-450 activity and chemical inhibitors

EV EX Met Enz ID CYP450 Hum Liver Microsome Data
type: Class
subclass of: EV EX Met Enz ID CYP450 Data
disjoint with: EV EX Met Enz Inhibit CYP450 Data
disjoint with: EV EX Met Enz Inhibit CYP450 Human Liver Microsome Data
disjoint with: EV EX Met Enz Inhibit CYP450 Human Recom Data
disjoint with: EV EX Met Enz Inhibit Data
disjoint with: EV Observational Data
disjoint with: EV PK DDI NR Data
disjoint with: EV PK DDI Observational Data
disjoint with: EV PK DDI Par Grps Data
disjoint with: EV PK DDI RCT Data
disjoint with: EV Population PK Data
disjoint with: Enzyme
disjoint with: Increased Drug AUC
disjoint with: Increased Drug Level
disjoint with: Induction
disjoint with: Inhibition
disjoint with: Inhibitor
disjoint with: Journal Peer reviewed
disjoint with: Metabolism
disjoint with: Microsomes
disjoint with: Non randomized Tx Assignment
disjoint with: Observation based DI Report Assessment tool
disjoint with: PK DDI
disjoint with: Pharmacodynamic Effect Consequences
disjoint with: Pharmacokinetic Effect Consequences
disjoint with: Pharmacokinetic Process
disjoint with: Public Reporting Database
disjoint with: Randomized Tx Assignment
disjoint with: Recombinant Protein System
disjoint with: Treatment Assignment
disjoint with: Xenobiotic Metabolism
disjoint with: in vitro Protein Source
disjoint with: BiochemicalReaction
disjoint with: Catalysis
disjoint with: Complex
disjoint with: ComplexAssembly
disjoint with: Control
disjoint with: Conversion
disjoint with: Degradation
disjoint with: Dna
disjoint with: DnaRegion
disjoint with: Entity
disjoint with: Gene
disjoint with: GeneticInteraction
disjoint with: Interaction
disjoint with: Modulation
disjoint with: MolecularInteraction
disjoint with: Pathway
disjoint with: PhysicalEntity
disjoint with: Protein
disjoint with: Rna
disjoint with: RnaRegion
disjoint with: SmallMolecule
disjoint with: TemplateReaction
disjoint with: TemplateReactionRegulation
disjoint with: Transport
disjoint with: TransportWithBiochemicalReaction
description: Data from a Cytochrome P-450 metabolic enzyme identification experiment using human liver microsomes that have been characterized for Cytochrome P-450 activity

EV EX Met Enz ID CYP450 Hum Liver Microsome Material
type: Class
subclass of: EV EX Met Enz ID CYP450 Material
disjoint with: EV EX Met Enz Inhibit CYP450 Human Liver Microsome Material
disjoint with: EV EX Met Enz Inhibit CYP450 Human Recom Material
disjoint with: EV EX Met Enz Inhibit CYP450 Material
disjoint with: EV EX Met Enz Inhibit Material
disjoint with: EV Observational Material
disjoint with: EV PK DDI NR Material
disjoint with: EV PK DDI Observational Material
disjoint with: EV PK DDI Par Grps Material
disjoint with: EV PK DDI RCT Material
disjoint with: EV Population PK Material
disjoint with: Enzyme
disjoint with: Increased Drug AUC
disjoint with: Increased Drug Level
disjoint with: Induction
disjoint with: Inhibition
disjoint with: Inhibitor
disjoint with: Journal Peer reviewed
disjoint with: Metabolism
disjoint with: Microsomes
disjoint with: Non randomized Tx Assignment
disjoint with: Observation based DI Report Assessment tool
disjoint with: PK DDI
disjoint with: Pharmacodynamic Effect Consequences
disjoint with: Pharmacokinetic Effect Consequences
disjoint with: Pharmacokinetic Process
disjoint with: Public Reporting Database
disjoint with: Randomized Tx Assignment
disjoint with: Recombinant Protein System
disjoint with: Treatment Assignment
disjoint with: Xenobiotic Metabolism
disjoint with: in vitro Protein Source
disjoint with: BiochemicalReaction
disjoint with: Catalysis
disjoint with: Complex
disjoint with: ComplexAssembly
disjoint with: Control
disjoint with: Conversion
disjoint with: Degradation
disjoint with: Dna
disjoint with: DnaRegion
disjoint with: Entity
disjoint with: Gene
disjoint with: GeneticInteraction
disjoint with: Interaction
disjoint with: Modulation
disjoint with: MolecularInteraction
disjoint with: Pathway
disjoint with: PhysicalEntity
disjoint with: Protein
disjoint with: Rna
disjoint with: RnaRegion
disjoint with: SmallMolecule
disjoint with: TemplateReaction
disjoint with: TemplateReactionRegulation
disjoint with: Transport
disjoint with: TransportWithBiochemicalReaction
description: Material from a Cytochrome P-450 metabolic enzyme identification experiment using human liver microsomes that have been characterized for Cytochrome P-450 activity

EV EX Met Enz ID CYP450 Hum Recom
type: Class
equivalent class: Class
  intersection of: EV EX Met Enz ID CYP450
  intersection of: Restriction
    on property: source of experimental protein
    has value: recombinant human cytochrome P450 isoenzymes
subclass of: EV EX Met Enz ID CYP450
disjoint with: EV EX Met Enz Inhibit
disjoint with: EV EX Met Enz Inhibit CYP450
disjoint with: EV EX Met Enz Inhibit CYP450 Human Liver Microsome
disjoint with: EV EX Met Enz Inhibit CYP450 Human Recom
disjoint with: EV Non Traceable Statement
disjoint with: EV Observational
disjoint with: EV PK DDI NR
disjoint with: EV PK DDI Observational
disjoint with: EV PK DDI Par Grps
disjoint with: EV PK DDI RCT
disjoint with: EV Population PK
disjoint with: EV Statement
disjoint with: EV Traceable Statement
disjoint with: Enzyme
disjoint with: Increased Drug AUC
disjoint with: Increased Drug Level
disjoint with: Induction
disjoint with: Inhibition
disjoint with: Inhibitor
disjoint with: Journal Peer reviewed
disjoint with: Metabolism
disjoint with: Microsomes
disjoint with: Non randomized Tx Assignment
disjoint with: Observation based DI Report Assessment tool
disjoint with: PK DDI
disjoint with: Pharmacodynamic Effect Consequences
disjoint with: Pharmacokinetic Effect Consequences
disjoint with: Pharmacokinetic Process
disjoint with: Public Reporting Database
disjoint with: Randomized Tx Assignment
disjoint with: Recombinant Protein System
disjoint with: Treatment Assignment
disjoint with: Xenobiotic Metabolism
disjoint with: in vitro Protein Source
disjoint with: BiochemicalReaction
disjoint with: Catalysis
disjoint with: Complex
disjoint with: ComplexAssembly
disjoint with: Control
disjoint with: Conversion
disjoint with: Degradation
disjoint with: Dna
disjoint with: DnaRegion
disjoint with: Entity
disjoint with: Gene
disjoint with: GeneticInteraction
disjoint with: Interaction
disjoint with: Modulation
disjoint with: MolecularInteraction
disjoint with: Pathway
disjoint with: PhysicalEntity
disjoint with: Protein
disjoint with: Rna
disjoint with: RnaRegion
disjoint with: SmallMolecule
disjoint with: TemplateReaction
disjoint with: TemplateReactionRegulation
disjoint with: Transport
disjoint with: TransportWithBiochemicalReaction
comment: A Cytochrome P450 metabolic enzyme identification experiment using recombinant human enzymes
description: A CYP450, recombinant, drug metabolism identification experiment with possibly NO probe enzyme inhibitor(s)

EV EX Met Enz ID CYP450 Hum Recom Antibody
type: Class
equivalent class: Class
  intersection of: EV EX Met Enz ID CYP450 Hum Recom
  intersection of: Restriction
    on property: uses inhibitor of enzyme
    some values from: Antibody Inhibitor
  intersection of: Restriction
    on property: uses inhibitor of enzyme
    all values from: Antibody Inhibitor
subclass of: EV EX Met Enz ID CYP450 Hum Recom
disjoint with: EV EX Met Enz ID CYP450 Hum Recom Chem
disjoint with: EV EX Met Enz Inhibit
disjoint with: EV EX Met Enz Inhibit CYP450
disjoint with: EV EX Met Enz Inhibit CYP450 Human Liver Microsome
disjoint with: EV EX Met Enz Inhibit CYP450 Human Recom
disjoint with: EV Non Traceable Statement
disjoint with: EV Observational
disjoint with: EV PK DDI NR
disjoint with: EV PK DDI Observational
disjoint with: EV PK DDI Par Grps
disjoint with: EV PK DDI RCT
disjoint with: EV Population PK
disjoint with: EV Statement
disjoint with: EV Traceable Statement
disjoint with: Enzyme
disjoint with: Increased Drug AUC
disjoint with: Increased Drug Level
disjoint with: Induction
disjoint with: Inhibition
disjoint with: Inhibitor
disjoint with: Journal Peer reviewed
disjoint with: Metabolism
disjoint with: Microsomes
disjoint with: Non randomized Tx Assignment
disjoint with: Observation based DI Report Assessment tool
disjoint with: PK DDI
disjoint with: Pharmacodynamic Effect Consequences
disjoint with: Pharmacokinetic Effect Consequences
disjoint with: Pharmacokinetic Process
disjoint with: Public Reporting Database
disjoint with: Randomized Tx Assignment
disjoint with: Recombinant Protein System
disjoint with: Treatment Assignment
disjoint with: Xenobiotic Metabolism
disjoint with: in vitro Protein Source
disjoint with: BiochemicalReaction
disjoint with: Catalysis
disjoint with: Complex
disjoint with: ComplexAssembly
disjoint with: Control
disjoint with: Conversion
disjoint with: Degradation
disjoint with: Dna
disjoint with: DnaRegion
disjoint with: Entity
disjoint with: Gene
disjoint with: GeneticInteraction
disjoint with: Interaction
disjoint with: Modulation
disjoint with: MolecularInteraction
disjoint with: Pathway
disjoint with: PhysicalEntity
disjoint with: Protein
disjoint with: Rna
disjoint with: RnaRegion
disjoint with: SmallMolecule
disjoint with: TemplateReaction
disjoint with: TemplateReactionRegulation
disjoint with: Transport
disjoint with: TransportWithBiochemicalReaction
comment: A Cytochrome P-450 metabolic enzyme identification experiment using recombinant human enzymes and antibodies as specific inhibitors
description: A CYP450, recombinant, drug metabolism identification experiment using antibody inhibitors

EV EX Met Enz ID CYP450 Hum Recom Antibody Data
type: Class
subclass of: EV EX Met Enz ID CYP450 Hum Recom Data
disjoint with: EV EX Met Enz Inhibit CYP450 Data
disjoint with: EV EX Met Enz Inhibit CYP450 Human Liver Microsome Data
disjoint with: EV EX Met Enz Inhibit CYP450 Human Recom Data
disjoint with: EV EX Met Enz Inhibit Data
disjoint with: EV Observational Data
disjoint with: EV PK DDI NR Data
disjoint with: EV PK DDI Observational Data
disjoint with: EV PK DDI Par Grps Data
disjoint with: EV PK DDI RCT Data
disjoint with: EV Population PK Data
disjoint with: Enzyme
disjoint with: Increased Drug AUC
disjoint with: Increased Drug Level
disjoint with: Induction
disjoint with: Inhibition
disjoint with: Inhibitor
disjoint with: Journal Peer reviewed
disjoint with: Metabolism
disjoint with: Microsomes
disjoint with: Non randomized Tx Assignment
disjoint with: Observation based DI Report Assessment tool
disjoint with: PK DDI
disjoint with: Pharmacodynamic Effect Consequences
disjoint with: Pharmacokinetic Effect Consequences
disjoint with: Pharmacokinetic Process
disjoint with: Public Reporting Database
disjoint with: Randomized Tx Assignment
disjoint with: Recombinant Protein System
disjoint with: Treatment Assignment
disjoint with: Xenobiotic Metabolism
disjoint with: in vitro Protein Source
disjoint with: BiochemicalReaction
disjoint with: Catalysis
disjoint with: Complex
disjoint with: ComplexAssembly
disjoint with: Control
disjoint with: Conversion
disjoint with: Degradation
disjoint with: Dna
disjoint with: DnaRegion
disjoint with: Entity
disjoint with: Gene
disjoint with: GeneticInteraction
disjoint with: Interaction
disjoint with: Modulation
disjoint with: MolecularInteraction
disjoint with: Pathway
disjoint with: PhysicalEntity
disjoint with: Protein
disjoint with: Rna
disjoint with: RnaRegion
disjoint with: SmallMolecule
disjoint with: TemplateReaction
disjoint with: TemplateReactionRegulation
disjoint with: Transport
disjoint with: TransportWithBiochemicalReaction
description: Data from a Cytochrome P-450 metabolic enzyme identification experiment using recombinant human enzymes and antibodies as specific inhibitors

EV EX Met Enz ID CYP450 Hum Recom Antibody Material
type: Class
subclass of: EV EX Met Enz ID CYP450 Hum Recom Material
disjoint with: EV EX Met Enz Inhibit CYP450 Human Liver Microsome Material
disjoint with: EV EX Met Enz Inhibit CYP450 Human Recom Material
disjoint with: EV EX Met Enz Inhibit CYP450 Material
disjoint with: EV EX Met Enz Inhibit Material
disjoint with: EV Observational Material
disjoint with: EV PK DDI NR Material
disjoint with: EV PK DDI Observational Material
disjoint with: EV PK DDI Par Grps Material
disjoint with: EV PK DDI RCT Material
disjoint with: EV Population PK Material
disjoint with: Enzyme
disjoint with: Increased Drug AUC
disjoint with: Increased Drug Level
disjoint with: Induction
disjoint with: Inhibition
disjoint with: Inhibitor
disjoint with: Journal Peer reviewed
disjoint with: Metabolism
disjoint with: Microsomes
disjoint with: Non randomized Tx Assignment
disjoint with: Observation based DI Report Assessment tool
disjoint with: PK DDI
disjoint with: Pharmacodynamic Effect Consequences
disjoint with: Pharmacokinetic Effect Consequences
disjoint with: Pharmacokinetic Process
disjoint with: Public Reporting Database
disjoint with: Randomized Tx Assignment
disjoint with: Recombinant Protein System
disjoint with: Treatment Assignment
disjoint with: Xenobiotic Metabolism
disjoint with: in vitro Protein Source
disjoint with: BiochemicalReaction
disjoint with: Catalysis
disjoint with: Complex
disjoint with: ComplexAssembly
disjoint with: Control
disjoint with: Conversion
disjoint with: Degradation
disjoint with: Dna
disjoint with: DnaRegion
disjoint with: Entity
disjoint with: Gene
disjoint with: GeneticInteraction
disjoint with: Interaction
disjoint with: Modulation
disjoint with: MolecularInteraction
disjoint with: Pathway
disjoint with: PhysicalEntity
disjoint with: Protein
disjoint with: Rna
disjoint with: RnaRegion
disjoint with: SmallMolecule
disjoint with: TemplateReaction
disjoint with: TemplateReactionRegulation
disjoint with: Transport
disjoint with: TransportWithBiochemicalReaction
description: Material from a Cytochrome P-450 metabolic enzyme identification experiment using recombinant human enzymes and antibodies as specific inhibitors

EV EX Met Enz ID CYP450 Hum Recom Chem
type: Class
equivalent class: Class
  intersection of: EV EX Met Enz ID CYP450 Hum Recom
  intersection of: Restriction
    on property: uses inhibitor of enzyme
    some values from: Chemical Inhibitor
  intersection of: Restriction
    on property: uses inhibitor of enzyme
    all values from: Chemical Inhibitor
subclass of: EV EX Met Enz ID CYP450 Hum Recom
disjoint with: EV EX Met Enz Inhibit
disjoint with: EV EX Met Enz Inhibit CYP450
disjoint with: EV EX Met Enz Inhibit CYP450 Human Liver Microsome
disjoint with: EV EX Met Enz Inhibit CYP450 Human Recom
disjoint with: EV Non Traceable Statement
disjoint with: EV Observational
disjoint with: EV PK DDI NR
disjoint with: EV PK DDI Observational
disjoint with: EV PK DDI Par Grps
disjoint with: EV PK DDI RCT
disjoint with: EV Population PK
disjoint with: EV Statement
disjoint with: EV Traceable Statement
disjoint with: Enzyme
disjoint with: Increased Drug AUC
disjoint with: Increased Drug Level
disjoint with: Induction
disjoint with: Inhibition
disjoint with: Inhibitor
disjoint with: Journal Peer reviewed
disjoint with: Metabolism
disjoint with: Microsomes
disjoint with: Non randomized Tx Assignment
disjoint with: Observation based DI Report Assessment tool
disjoint with: PK DDI
disjoint with: Pharmacodynamic Effect Consequences
disjoint with: Pharmacokinetic Effect Consequences
disjoint with: Pharmacokinetic Process
disjoint with: Public Reporting Database
disjoint with: Randomized Tx Assignment
disjoint with: Recombinant Protein System
disjoint with: Treatment Assignment
disjoint with: Xenobiotic Metabolism
disjoint with: in vitro Protein Source
disjoint with: BiochemicalReaction
disjoint with: Catalysis
disjoint with: Complex
disjoint with: ComplexAssembly
disjoint with: Control
disjoint with: Conversion
disjoint with: Degradation
disjoint with: Dna
disjoint with: DnaRegion
disjoint with: Entity
disjoint with: Gene
disjoint with: GeneticInteraction
disjoint with: Interaction
disjoint with: Modulation
disjoint with: MolecularInteraction
disjoint with: Pathway
disjoint with: PhysicalEntity
disjoint with: Protein
disjoint with: Rna
disjoint with: RnaRegion
disjoint with: SmallMolecule
disjoint with: TemplateReaction
disjoint with: TemplateReactionRegulation
disjoint with: Transport
disjoint with: TransportWithBiochemicalReaction
comment: A Cytochrome P-450 metabolic enzyme identification experiment using recombinant human enzymes and chemical inhibitors
description: A CYP450, recombinant, drug metabolism identification experiment using chemical inhibitors

EV EX Met Enz ID CYP450 Hum Recom Chem Data
type: Class
subclass of: EV EX Met Enz ID CYP450 Hum Recom Data
disjoint with: EV EX Met Enz Inhibit CYP450 Data
disjoint with: EV EX Met Enz Inhibit CYP450 Human Liver Microsome Data
disjoint with: EV EX Met Enz Inhibit CYP450 Human Recom Data
disjoint with: EV EX Met Enz Inhibit Data
disjoint with: EV Observational Data
disjoint with: EV PK DDI NR Data
disjoint with: EV PK DDI Observational Data
disjoint with: EV PK DDI Par Grps Data
disjoint with: EV PK DDI RCT Data
disjoint with: EV Population PK Data
disjoint with: Enzyme
disjoint with: Increased Drug AUC
disjoint with: Increased Drug Level
disjoint with: Induction
disjoint with: Inhibition
disjoint with: Inhibitor
disjoint with: Journal Peer reviewed
disjoint with: Metabolism
disjoint with: Microsomes
disjoint with: Non randomized Tx Assignment
disjoint with: Observation based DI Report Assessment tool
disjoint with: PK DDI
disjoint with: Pharmacodynamic Effect Consequences
disjoint with: Pharmacokinetic Effect Consequences
disjoint with: Pharmacokinetic Process
disjoint with: Public Reporting Database
disjoint with: Randomized Tx Assignment
disjoint with: Recombinant Protein System
disjoint with: Treatment Assignment
disjoint with: Xenobiotic Metabolism
disjoint with: in vitro Protein Source
disjoint with: BiochemicalReaction
disjoint with: Catalysis
disjoint with: Complex
disjoint with: ComplexAssembly
disjoint with: Control
disjoint with: Conversion
disjoint with: Degradation
disjoint with: Dna
disjoint with: DnaRegion
disjoint with: Entity
disjoint with: Gene
disjoint with: GeneticInteraction
disjoint with: Interaction
disjoint with: Modulation
disjoint with: MolecularInteraction
disjoint with: Pathway
disjoint with: PhysicalEntity
disjoint with: Protein
disjoint with: Rna
disjoint with: RnaRegion
disjoint with: SmallMolecule
disjoint with: TemplateReaction
disjoint with: TemplateReactionRegulation
disjoint with: Transport
disjoint with: TransportWithBiochemicalReaction
description: Data from a Cytochrome P-450 metabolic enzyme identification experiment using recombinant human enzymes and chemical inhibitors

EV EX Met Enz ID CYP450 Hum Recom Chem Material
type: Class
subclass of: EV EX Met Enz ID CYP450 Hum Recom Material
disjoint with: EV EX Met Enz Inhibit CYP450 Human Liver Microsome Material
disjoint with: EV EX Met Enz Inhibit CYP450 Human Recom Material
disjoint with: EV EX Met Enz Inhibit CYP450 Material
disjoint with: EV EX Met Enz Inhibit Material
disjoint with: EV Observational Material
disjoint with: EV PK DDI NR Material
disjoint with: EV PK DDI Observational Material
disjoint with: EV PK DDI Par Grps Material
disjoint with: EV PK DDI RCT Material
disjoint with: EV Population PK Material
disjoint with: Enzyme
disjoint with: Increased Drug AUC
disjoint with: Increased Drug Level
disjoint with: Induction
disjoint with: Inhibition
disjoint with: Inhibitor
disjoint with: Journal Peer reviewed
disjoint with: Metabolism
disjoint with: Microsomes
disjoint with: Non randomized Tx Assignment
disjoint with: Observation based DI Report Assessment tool
disjoint with: PK DDI
disjoint with: Pharmacodynamic Effect Consequences
disjoint with: Pharmacokinetic Effect Consequences
disjoint with: Pharmacokinetic Process
disjoint with: Public Reporting Database
disjoint with: Randomized Tx Assignment
disjoint with: Recombinant Protein System
disjoint with: Treatment Assignment
disjoint with: Xenobiotic Metabolism
disjoint with: in vitro Protein Source
disjoint with: BiochemicalReaction
disjoint with: Catalysis
disjoint with: Complex
disjoint with: ComplexAssembly
disjoint with: Control
disjoint with: Conversion
disjoint with: Degradation
disjoint with: Dna
disjoint with: DnaRegion
disjoint with: Entity
disjoint with: Gene
disjoint with: GeneticInteraction
disjoint with: Interaction
disjoint with: Modulation
disjoint with: MolecularInteraction
disjoint with: Pathway
disjoint with: PhysicalEntity
disjoint with: Protein
disjoint with: Rna
disjoint with: RnaRegion
disjoint with: SmallMolecule
disjoint with: TemplateReaction
disjoint with: TemplateReactionRegulation
disjoint with: Transport
disjoint with: TransportWithBiochemicalReaction
description: Material from a Cytochrome P-450 metabolic enzyme identification experiment using recombinant human enzymes and chemical inhibitors

EV EX Met Enz ID CYP450 Hum Recom Data
type: Class
subclass of: EV EX Met Enz ID CYP450 Data
disjoint with: EV EX Met Enz Inhibit CYP450 Data
disjoint with: EV EX Met Enz Inhibit CYP450 Human Liver Microsome Data
disjoint with: EV EX Met Enz Inhibit CYP450 Human Recom Data
disjoint with: EV EX Met Enz Inhibit Data
disjoint with: EV Observational Data
disjoint with: EV PK DDI NR Data
disjoint with: EV PK DDI Observational Data
disjoint with: EV PK DDI Par Grps Data
disjoint with: EV PK DDI RCT Data
disjoint with: EV Population PK Data
disjoint with: Enzyme
disjoint with: Increased Drug AUC
disjoint with: Increased Drug Level
disjoint with: Induction
disjoint with: Inhibition
disjoint with: Inhibitor
disjoint with: Journal Peer reviewed
disjoint with: Metabolism
disjoint with: Microsomes
disjoint with: Non randomized Tx Assignment
disjoint with: Observation based DI Report Assessment tool
disjoint with: PK DDI
disjoint with: Pharmacodynamic Effect Consequences
disjoint with: Pharmacokinetic Effect Consequences
disjoint with: Pharmacokinetic Process
disjoint with: Public Reporting Database
disjoint with: Randomized Tx Assignment
disjoint with: Recombinant Protein System
disjoint with: Treatment Assignment
disjoint with: Xenobiotic Metabolism
disjoint with: in vitro Protein Source
disjoint with: BiochemicalReaction
disjoint with: Catalysis
disjoint with: Complex
disjoint with: ComplexAssembly
disjoint with: Control
disjoint with: Conversion
disjoint with: Degradation
disjoint with: Dna
disjoint with: DnaRegion
disjoint with: Entity
disjoint with: Gene
disjoint with: GeneticInteraction
disjoint with: Interaction
disjoint with: Modulation
disjoint with: MolecularInteraction
disjoint with: Pathway
disjoint with: PhysicalEntity
disjoint with: Protein
disjoint with: Rna
disjoint with: RnaRegion
disjoint with: SmallMolecule
disjoint with: TemplateReaction
disjoint with: TemplateReactionRegulation
disjoint with: Transport
disjoint with: TransportWithBiochemicalReaction
description: Data from a Cytochrome P450 metabolic enzyme identification experiment using recombinant human enzymes

EV EX Met Enz ID CYP450 Hum Recom Material
type: Class
subclass of: EV EX Met Enz ID CYP450 Material
disjoint with: EV EX Met Enz Inhibit CYP450 Human Liver Microsome Material
disjoint with: EV EX Met Enz Inhibit CYP450 Human Recom Material
disjoint with: EV EX Met Enz Inhibit CYP450 Material
disjoint with: EV EX Met Enz Inhibit Material
disjoint with: EV Observational Material
disjoint with: EV PK DDI NR Material
disjoint with: EV PK DDI Observational Material
disjoint with: EV PK DDI Par Grps Material
disjoint with: EV PK DDI RCT Material
disjoint with: EV Population PK Material
disjoint with: Enzyme
disjoint with: Increased Drug AUC
disjoint with: Increased Drug Level
disjoint with: Induction
disjoint with: Inhibition
disjoint with: Inhibitor
disjoint with: Journal Peer reviewed
disjoint with: Metabolism
disjoint with: Microsomes
disjoint with: Non randomized Tx Assignment
disjoint with: Observation based DI Report Assessment tool
disjoint with: PK DDI
disjoint with: Pharmacodynamic Effect Consequences
disjoint with: Pharmacokinetic Effect Consequences
disjoint with: Pharmacokinetic Process
disjoint with: Public Reporting Database
disjoint with: Randomized Tx Assignment
disjoint with: Recombinant Protein System
disjoint with: Treatment Assignment
disjoint with: Xenobiotic Metabolism
disjoint with: in vitro Protein Source
disjoint with: BiochemicalReaction
disjoint with: Catalysis
disjoint with: Complex
disjoint with: ComplexAssembly
disjoint with: Control
disjoint with: Conversion
disjoint with: Degradation
disjoint with: Dna
disjoint with: DnaRegion
disjoint with: Entity
disjoint with: Gene
disjoint with: GeneticInteraction
disjoint with: Interaction
disjoint with: Modulation
disjoint with: MolecularInteraction
disjoint with: Pathway
disjoint with: PhysicalEntity
disjoint with: Protein
disjoint with: Rna
disjoint with: RnaRegion
disjoint with: SmallMolecule
disjoint with: TemplateReaction
disjoint with: TemplateReactionRegulation
disjoint with: Transport
disjoint with: TransportWithBiochemicalReaction
description: Material from a Cytochrome P450 metabolic enzyme identification experiment using recombinant human enzymes

EV EX Met Enz ID CYP450 Material
type: Class
subclass of: EV EX Met Enz ID Material
disjoint with: EV EX Met Enz Inhibit CYP450 Human Liver Microsome Material
disjoint with: EV EX Met Enz Inhibit CYP450 Human Recom Material
disjoint with: EV EX Met Enz Inhibit CYP450 Material
disjoint with: EV EX Met Enz Inhibit Material
disjoint with: EV Observational Material
disjoint with: EV PK DDI NR Material
disjoint with: EV PK DDI Observational Material
disjoint with: EV PK DDI Par Grps Material
disjoint with: EV PK DDI RCT Material
disjoint with: EV Population PK Material
disjoint with: Enzyme
disjoint with: Increased Drug AUC
disjoint with: Increased Drug Level
disjoint with: Induction
disjoint with: Inhibition
disjoint with: Inhibitor
disjoint with: Journal Peer reviewed
disjoint with: Metabolism
disjoint with: Microsomes
disjoint with: Non randomized Tx Assignment
disjoint with: Observation based DI Report Assessment tool
disjoint with: PK DDI
disjoint with: Pharmacodynamic Effect Consequences
disjoint with: Pharmacokinetic Effect Consequences
disjoint with: Pharmacokinetic Process
disjoint with: Public Reporting Database
disjoint with: Randomized Tx Assignment
disjoint with: Recombinant Protein System
disjoint with: Treatment Assignment
disjoint with: Xenobiotic Metabolism
disjoint with: in vitro Protein Source
disjoint with: BiochemicalReaction
disjoint with: Catalysis
disjoint with: Complex
disjoint with: ComplexAssembly
disjoint with: Control
disjoint with: Conversion
disjoint with: Degradation
disjoint with: Dna
disjoint with: DnaRegion
disjoint with: Entity
disjoint with: Gene
disjoint with: GeneticInteraction
disjoint with: Interaction
disjoint with: Modulation
disjoint with: MolecularInteraction
disjoint with: Pathway
disjoint with: PhysicalEntity
disjoint with: Protein
disjoint with: Rna
disjoint with: RnaRegion
disjoint with: SmallMolecule
disjoint with: TemplateReaction
disjoint with: TemplateReactionRegulation
disjoint with: Transport
disjoint with: TransportWithBiochemicalReaction
description: Material from a metabolic enzyme identification experiment specifically designed to identify the Cytochrome P-450 enzymes involved in the metabolism of a drug

EV EX Met Enz ID Data
type: Class
subclass of: Evidence Type Data
disjoint with: EV EX Met Enz Inhibit CYP450 Data
disjoint with: EV EX Met Enz Inhibit CYP450 Human Liver Microsome Data
disjoint with: EV EX Met Enz Inhibit CYP450 Human Recom Data
disjoint with: EV EX Met Enz Inhibit Data
disjoint with: EV Observational Data
disjoint with: EV PK DDI NR Data
disjoint with: EV PK DDI Observational Data
disjoint with: EV PK DDI Par Grps Data
disjoint with: EV PK DDI RCT Data
disjoint with: EV Population PK Data
disjoint with: Enzyme
disjoint with: Increased Drug AUC
disjoint with: Increased Drug Level
disjoint with: Induction
disjoint with: Inhibition
disjoint with: Inhibitor
disjoint with: Journal Peer reviewed
disjoint with: Metabolism
disjoint with: Microsomes
disjoint with: Non randomized Tx Assignment
disjoint with: Observation based DI Report Assessment tool
disjoint with: PK DDI
disjoint with: Pharmacodynamic Effect Consequences
disjoint with: Pharmacokinetic Effect Consequences
disjoint with: Pharmacokinetic Process
disjoint with: Public Reporting Database
disjoint with: Randomized Tx Assignment
disjoint with: Recombinant Protein System
disjoint with: Treatment Assignment
disjoint with: Xenobiotic Metabolism
disjoint with: in vitro Protein Source
disjoint with: BiochemicalReaction
disjoint with: Catalysis
disjoint with: Complex
disjoint with: ComplexAssembly
disjoint with: Control
disjoint with: Conversion
disjoint with: Degradation
disjoint with: Dna
disjoint with: DnaRegion
disjoint with: Entity
disjoint with: Gene
disjoint with: GeneticInteraction
disjoint with: Interaction
disjoint with: Modulation
disjoint with: MolecularInteraction
disjoint with: Pathway
disjoint with: PhysicalEntity
disjoint with: Protein
disjoint with: Rna
disjoint with: RnaRegion
disjoint with: SmallMolecule
disjoint with: TemplateReaction
disjoint with: TemplateReactionRegulation
disjoint with: Transport
disjoint with: TransportWithBiochemicalReaction
description: Data from a drug metabolism identification experiment -- an experiment conducted with biological tissues and/or chemical compounds in a laboratory designed to "...identify the specific enzymes responsible for the metabolism of a drug'' (fda2006a, p. 25)

EV EX Met Enz ID Material
type: Class
subclass of: Evidence Type Material
disjoint with: EV EX Met Enz Inhibit CYP450 Human Liver Microsome Material
disjoint with: EV EX Met Enz Inhibit CYP450 Human Recom Material
disjoint with: EV EX Met Enz Inhibit CYP450 Material
disjoint with: EV EX Met Enz Inhibit Material
disjoint with: EV Observational Material
disjoint with: EV PK DDI NR Material
disjoint with: EV PK DDI Observational Material
disjoint with: EV PK DDI Par Grps Material
disjoint with: EV PK DDI RCT Material
disjoint with: EV Population PK Material
disjoint with: Enzyme
disjoint with: Increased Drug AUC
disjoint with: Increased Drug Level
disjoint with: Induction
disjoint with: Inhibition
disjoint with: Inhibitor
disjoint with: Journal Peer reviewed
disjoint with: Metabolism
disjoint with: Microsomes
disjoint with: Non randomized Tx Assignment
disjoint with: Observation based DI Report Assessment tool
disjoint with: PK DDI
disjoint with: Pharmacodynamic Effect Consequences
disjoint with: Pharmacokinetic Effect Consequences
disjoint with: Pharmacokinetic Process
disjoint with: Public Reporting Database
disjoint with: Randomized Tx Assignment
disjoint with: Recombinant Protein System
disjoint with: Treatment Assignment
disjoint with: Xenobiotic Metabolism
disjoint with: in vitro Protein Source
disjoint with: BiochemicalReaction
disjoint with: Catalysis
disjoint with: Complex
disjoint with: ComplexAssembly
disjoint with: Control
disjoint with: Conversion
disjoint with: Degradation
disjoint with: Dna
disjoint with: DnaRegion
disjoint with: Entity
disjoint with: Gene
disjoint with: GeneticInteraction
disjoint with: Interaction
disjoint with: Modulation
disjoint with: MolecularInteraction
disjoint with: Pathway
disjoint with: PhysicalEntity
disjoint with: Protein
disjoint with: Rna
disjoint with: RnaRegion
disjoint with: SmallMolecule
disjoint with: TemplateReaction
disjoint with: TemplateReactionRegulation
disjoint with: Transport
disjoint with: TransportWithBiochemicalReaction
description: Material from a drug metabolism identification experiment -- an experiment conducted with biological tissues and/or chemical compounds in a laboratory designed to "...identify the specific enzymes responsible for the metabolism of a drug'' (fda2006a, p. 25)

EV EX Met Enz Inhibit
type: Class
equivalent class: Class
  intersection of: Evidence Type
  intersection of: Restriction
    on property: has focus of inquiry
    some values from: Drug Metabolism
  intersection of: Restriction
    on property: has study design
    some values from: in vitro study
  intersection of: Restriction
    on property: investigates drug
    some values from: Drug
  intersection of: Restriction
    on property: source of experimental protein
    some values from: in vitro Protein Source
  intersection of: Restriction
    on property: tests if drug inhibits
    some values from: Enzyme
  intersection of: Restriction
    on property: has focus of inquiry
    all values from: Drug Metabolism
  intersection of: Restriction
    on property: investigates drug
    all values from: Drug
  intersection of: Restriction
    on property: source of experimental protein
    all values from: in vitro Protein Source
  intersection of: Restriction
    on property: tests if drug inhibits
    all values from: Enzyme
subclass of: Evidence Type
disjoint with: EV Non Traceable Statement
disjoint with: EV Observational
disjoint with: EV PK DDI NR
disjoint with: EV PK DDI Observational
disjoint with: EV PK DDI Par Grps
disjoint with: EV PK DDI RCT
disjoint with: EV Population PK
disjoint with: EV Statement
disjoint with: EV Traceable Statement
disjoint with: Enzyme
disjoint with: Increased Drug AUC
disjoint with: Increased Drug Level
disjoint with: Induction
disjoint with: Inhibition
disjoint with: Inhibitor
disjoint with: Journal Peer reviewed
disjoint with: Metabolism
disjoint with: Microsomes
disjoint with: Non randomized Tx Assignment
disjoint with: Observation based DI Report Assessment tool
disjoint with: PK DDI
disjoint with: Pharmacodynamic Effect Consequences
disjoint with: Pharmacokinetic Effect Consequences
disjoint with: Pharmacokinetic Process
disjoint with: Public Reporting Database
disjoint with: Randomized Tx Assignment
disjoint with: Recombinant Protein System
disjoint with: Treatment Assignment
disjoint with: Xenobiotic Metabolism
disjoint with: in vitro Protein Source
disjoint with: BiochemicalReaction
disjoint with: Catalysis
disjoint with: Complex
disjoint with: ComplexAssembly
disjoint with: Control
disjoint with: Conversion
disjoint with: Degradation
disjoint with: Dna
disjoint with: DnaRegion
disjoint with: Entity
disjoint with: Gene
disjoint with: GeneticInteraction
disjoint with: Interaction
disjoint with: Modulation
disjoint with: MolecularInteraction
disjoint with: Pathway
disjoint with: PhysicalEntity
disjoint with: Protein
disjoint with: Rna
disjoint with: RnaRegion
disjoint with: SmallMolecule
disjoint with: TemplateReaction
disjoint with: TemplateReactionRegulation
disjoint with: Transport
disjoint with: TransportWithBiochemicalReaction
comment: An experiment conducted with biological tissues and/or chemical compounds in a laboratory designed to determine whether or not a drug inhibits a specific drug-metabolizing enzyme
description: A metabolic enzyme inhibition experiment

EV EX Met Enz Inhibit CYP450
type: Class
equivalent class: Class
  intersection of: EV EX Met Enz Inhibit
  intersection of: Restriction
    on property: tests if drug inhibits
    some values from: Cytochrome P450
  intersection of: Restriction
    on property: tests if drug inhibits
    all values from: Cytochrome P450
subclass of: EV EX Met Enz Inhibit
disjoint with: EV Non Traceable Statement
disjoint with: EV Observational
disjoint with: EV PK DDI NR
disjoint with: EV PK DDI Observational
disjoint with: EV PK DDI Par Grps
disjoint with: EV PK DDI RCT
disjoint with: EV Population PK
disjoint with: EV Statement
disjoint with: EV Traceable Statement
disjoint with: Enzyme
disjoint with: Increased Drug AUC
disjoint with: Increased Drug Level
disjoint with: Induction
disjoint with: Inhibition
disjoint with: Inhibitor
disjoint with: Journal Peer reviewed
disjoint with: Metabolism
disjoint with: Microsomes
disjoint with: Non randomized Tx Assignment
disjoint with: Observation based DI Report Assessment tool
disjoint with: PK DDI
disjoint with: Pharmacodynamic Effect Consequences
disjoint with: Pharmacokinetic Effect Consequences
disjoint with: Pharmacokinetic Process
disjoint with: Public Reporting Database
disjoint with: Randomized Tx Assignment
disjoint with: Recombinant Protein System
disjoint with: Treatment Assignment
disjoint with: Xenobiotic Metabolism
disjoint with: in vitro Protein Source
disjoint with: BiochemicalReaction
disjoint with: Catalysis
disjoint with: Complex
disjoint with: ComplexAssembly
disjoint with: Control
disjoint with: Conversion
disjoint with: Degradation
disjoint with: Dna
disjoint with: DnaRegion
disjoint with: Entity
disjoint with: Gene
disjoint with: GeneticInteraction
disjoint with: Interaction
disjoint with: Modulation
disjoint with: MolecularInteraction
disjoint with: Pathway
disjoint with: PhysicalEntity
disjoint with: Protein
disjoint with: Rna
disjoint with: RnaRegion
disjoint with: SmallMolecule
disjoint with: TemplateReaction
disjoint with: TemplateReactionRegulation
disjoint with: Transport
disjoint with: TransportWithBiochemicalReaction
comment: A metabolic \textbf{inhibition} experiment specifically designed to determine whether or not a drug inhibits a specific CYP450 enzyme
description: A CYP450 metabolic enzyme inhibition experiment

EV EX Met Enz Inhibit CYP450 Data
type: Class
subclass of: EV EX Met Enz Inhibit Data
disjoint with: EV Observational Data
disjoint with: EV PK DDI NR Data
disjoint with: EV PK DDI Observational Data
disjoint with: EV PK DDI Par Grps Data
disjoint with: EV PK DDI RCT Data
disjoint with: EV Population PK Data
disjoint with: Enzyme
disjoint with: Increased Drug AUC
disjoint with: Increased Drug Level
disjoint with: Induction
disjoint with: Inhibition
disjoint with: Inhibitor
disjoint with: Journal Peer reviewed
disjoint with: Metabolism
disjoint with: Microsomes
disjoint with: Non randomized Tx Assignment
disjoint with: Observation based DI Report Assessment tool
disjoint with: PK DDI
disjoint with: Pharmacodynamic Effect Consequences
disjoint with: Pharmacokinetic Effect Consequences
disjoint with: Pharmacokinetic Process
disjoint with: Public Reporting Database
disjoint with: Randomized Tx Assignment
disjoint with: Recombinant Protein System
disjoint with: Treatment Assignment
disjoint with: Xenobiotic Metabolism
disjoint with: in vitro Protein Source
disjoint with: BiochemicalReaction
disjoint with: Catalysis
disjoint with: Complex
disjoint with: ComplexAssembly
disjoint with: Control
disjoint with: Conversion
disjoint with: Degradation
disjoint with: Dna
disjoint with: DnaRegion
disjoint with: Entity
disjoint with: Gene
disjoint with: GeneticInteraction
disjoint with: Interaction
disjoint with: Modulation
disjoint with: MolecularInteraction
disjoint with: Pathway
disjoint with: PhysicalEntity
disjoint with: Protein
disjoint with: Rna
disjoint with: RnaRegion
disjoint with: SmallMolecule
disjoint with: TemplateReaction
disjoint with: TemplateReactionRegulation
disjoint with: Transport
disjoint with: TransportWithBiochemicalReaction
description: Data from a metabolic inhibition experiment specifically designed to determine whether or not a drug inhibits a specific CYP450 enzyme

EV EX Met Enz Inhibit CYP450 Human Liver Microsome
type: Class
equivalent class: Class
  intersection of: EV EX Met Enz Inhibit CYP450
  intersection of: Restriction
    on property: source of experimental protein
    has value: human liver microsomes
subclass of: EV EX Met Enz Inhibit CYP450
disjoint with: EV Non Traceable Statement
disjoint with: EV Observational
disjoint with: EV PK DDI NR
disjoint with: EV PK DDI Observational
disjoint with: EV PK DDI Par Grps
disjoint with: EV PK DDI RCT
disjoint with: EV Population PK
disjoint with: EV Statement
disjoint with: EV Traceable Statement
disjoint with: Enzyme
disjoint with: Increased Drug AUC
disjoint with: Increased Drug Level
disjoint with: Induction
disjoint with: Inhibition
disjoint with: Inhibitor
disjoint with: Journal Peer reviewed
disjoint with: Metabolism
disjoint with: Microsomes
disjoint with: Non randomized Tx Assignment
disjoint with: Observation based DI Report Assessment tool
disjoint with: PK DDI
disjoint with: Pharmacodynamic Effect Consequences
disjoint with: Pharmacokinetic Effect Consequences
disjoint with: Pharmacokinetic Process
disjoint with: Public Reporting Database
disjoint with: Randomized Tx Assignment
disjoint with: Recombinant Protein System
disjoint with: Treatment Assignment
disjoint with: Xenobiotic Metabolism
disjoint with: in vitro Protein Source
disjoint with: BiochemicalReaction
disjoint with: Catalysis
disjoint with: Complex
disjoint with: ComplexAssembly
disjoint with: Control
disjoint with: Conversion
disjoint with: Degradation
disjoint with: Dna
disjoint with: DnaRegion
disjoint with: Entity
disjoint with: Gene
disjoint with: GeneticInteraction
disjoint with: Interaction
disjoint with: Modulation
disjoint with: MolecularInteraction
disjoint with: Pathway
disjoint with: PhysicalEntity
disjoint with: Protein
disjoint with: Rna
disjoint with: RnaRegion
disjoint with: SmallMolecule
disjoint with: TemplateReaction
disjoint with: TemplateReactionRegulation
disjoint with: Transport
disjoint with: TransportWithBiochemicalReaction
comment: A Cytochrome P-450 metabolic enzyme inhibition experiment using human liver microsomes that have been characterized for Cytochrome P-450 activity
description: A CYP450, human microsome, metabolic enzyme inhibition experiment

EV EX Met Enz Inhibit CYP450 Human Liver Microsome Data
type: Class
subclass of: EV EX Met Enz Inhibit CYP450 Data
disjoint with: EV Observational Data
disjoint with: EV PK DDI NR Data
disjoint with: EV PK DDI Observational Data
disjoint with: EV PK DDI Par Grps Data
disjoint with: EV PK DDI RCT Data
disjoint with: EV Population PK Data
disjoint with: Enzyme
disjoint with: Increased Drug AUC
disjoint with: Increased Drug Level
disjoint with: Induction
disjoint with: Inhibition
disjoint with: Inhibitor
disjoint with: Journal Peer reviewed
disjoint with: Metabolism
disjoint with: Microsomes
disjoint with: Non randomized Tx Assignment
disjoint with: Observation based DI Report Assessment tool
disjoint with: PK DDI
disjoint with: Pharmacodynamic Effect Consequences
disjoint with: Pharmacokinetic Effect Consequences
disjoint with: Pharmacokinetic Process
disjoint with: Public Reporting Database
disjoint with: Randomized Tx Assignment
disjoint with: Recombinant Protein System
disjoint with: Treatment Assignment
disjoint with: Xenobiotic Metabolism
disjoint with: in vitro Protein Source
disjoint with: BiochemicalReaction
disjoint with: Catalysis
disjoint with: Complex
disjoint with: ComplexAssembly
disjoint with: Control
disjoint with: Conversion
disjoint with: Degradation
disjoint with: Dna
disjoint with: DnaRegion
disjoint with: Entity
disjoint with: Gene
disjoint with: GeneticInteraction
disjoint with: Interaction
disjoint with: Modulation
disjoint with: MolecularInteraction
disjoint with: Pathway
disjoint with: PhysicalEntity
disjoint with: Protein
disjoint with: Rna
disjoint with: RnaRegion
disjoint with: SmallMolecule
disjoint with: TemplateReaction
disjoint with: TemplateReactionRegulation
disjoint with: Transport
disjoint with: TransportWithBiochemicalReaction
description: Data from a cytochrome P-450 metabolic enzyme inhibition experiment using human liver microsomes that have been characterized for Cytochrome P-450 activity

EV EX Met Enz Inhibit CYP450 Human Liver Microsome Material
type: Class
subclass of: EV EX Met Enz Inhibit CYP450 Material
disjoint with: EV Observational Material
disjoint with: EV PK DDI NR Material
disjoint with: EV PK DDI Observational Material
disjoint with: EV PK DDI Par Grps Material
disjoint with: EV PK DDI RCT Material
disjoint with: EV Population PK Material
disjoint with: Enzyme
disjoint with: Increased Drug AUC
disjoint with: Increased Drug Level
disjoint with: Induction
disjoint with: Inhibition
disjoint with: Inhibitor
disjoint with: Journal Peer reviewed
disjoint with: Metabolism
disjoint with: Microsomes
disjoint with: Non randomized Tx Assignment
disjoint with: Observation based DI Report Assessment tool
disjoint with: PK DDI
disjoint with: Pharmacodynamic Effect Consequences
disjoint with: Pharmacokinetic Effect Consequences
disjoint with: Pharmacokinetic Process
disjoint with: Public Reporting Database
disjoint with: Randomized Tx Assignment
disjoint with: Recombinant Protein System
disjoint with: Treatment Assignment
disjoint with: Xenobiotic Metabolism
disjoint with: in vitro Protein Source
disjoint with: BiochemicalReaction
disjoint with: Catalysis
disjoint with: Complex
disjoint with: ComplexAssembly
disjoint with: Control
disjoint with: Conversion
disjoint with: Degradation
disjoint with: Dna
disjoint with: DnaRegion
disjoint with: Entity
disjoint with: Gene
disjoint with: GeneticInteraction
disjoint with: Interaction
disjoint with: Modulation
disjoint with: MolecularInteraction
disjoint with: Pathway
disjoint with: PhysicalEntity
disjoint with: Protein
disjoint with: Rna
disjoint with: RnaRegion
disjoint with: SmallMolecule
disjoint with: TemplateReaction
disjoint with: TemplateReactionRegulation
disjoint with: Transport
disjoint with: TransportWithBiochemicalReaction
description: Material from a cytochrome P-450 metabolic enzyme inhibition experiment using human liver microsomes that have been characterized for Cytochrome P-450 activity

EV EX Met Enz Inhibit CYP450 Human Recom
type: Class
equivalent class: Class
  intersection of: EV EX Met Enz Inhibit CYP450
  intersection of: Restriction
    on property: source of experimental protein
    has value: recombinant human cytochrome P450 isoenzymes
subclass of: EV EX Met Enz Inhibit CYP450
disjoint with: EV Non Traceable Statement
disjoint with: EV Observational
disjoint with: EV PK DDI NR
disjoint with: EV PK DDI Observational
disjoint with: EV PK DDI Par Grps
disjoint with: EV PK DDI RCT
disjoint with: EV Population PK
disjoint with: EV Statement
disjoint with: EV Traceable Statement
disjoint with: Enzyme
disjoint with: Increased Drug AUC
disjoint with: Increased Drug Level
disjoint with: Induction
disjoint with: Inhibition
disjoint with: Inhibitor
disjoint with: Journal Peer reviewed
disjoint with: Metabolism
disjoint with: Microsomes
disjoint with: Non randomized Tx Assignment
disjoint with: Observation based DI Report Assessment tool
disjoint with: PK DDI
disjoint with: Pharmacodynamic Effect Consequences
disjoint with: Pharmacokinetic Effect Consequences
disjoint with: Pharmacokinetic Process
disjoint with: Public Reporting Database
disjoint with: Randomized Tx Assignment
disjoint with: Recombinant Protein System
disjoint with: Treatment Assignment
disjoint with: Xenobiotic Metabolism
disjoint with: in vitro Protein Source
disjoint with: BiochemicalReaction
disjoint with: Catalysis
disjoint with: Complex
disjoint with: ComplexAssembly
disjoint with: Control
disjoint with: Conversion
disjoint with: Degradation
disjoint with: Dna
disjoint with: DnaRegion
disjoint with: Entity
disjoint with: Gene
disjoint with: GeneticInteraction
disjoint with: Interaction
disjoint with: Modulation
disjoint with: MolecularInteraction
disjoint with: Pathway
disjoint with: PhysicalEntity
disjoint with: Protein
disjoint with: Rna
disjoint with: RnaRegion
disjoint with: SmallMolecule
disjoint with: TemplateReaction
disjoint with: TemplateReactionRegulation
disjoint with: Transport
disjoint with: TransportWithBiochemicalReaction
comment: A Cytochrome P-450 inhibition experiment using recombinant human enzymes
description: A CYP450, recombinant, metabolic enzyme inhibition experiment

EV EX Met Enz Inhibit CYP450 Human Recom Data
type: Class
subclass of: EV EX Met Enz Inhibit CYP450 Data
disjoint with: EV Observational Data
disjoint with: EV PK DDI NR Data
disjoint with: EV PK DDI Observational Data
disjoint with: EV PK DDI Par Grps Data
disjoint with: EV PK DDI RCT Data
disjoint with: EV Population PK Data
disjoint with: Enzyme
disjoint with: Increased Drug AUC
disjoint with: Increased Drug Level
disjoint with: Induction
disjoint with: Inhibition
disjoint with: Inhibitor
disjoint with: Journal Peer reviewed
disjoint with: Metabolism
disjoint with: Microsomes
disjoint with: Non randomized Tx Assignment
disjoint with: Observation based DI Report Assessment tool
disjoint with: PK DDI
disjoint with: Pharmacodynamic Effect Consequences
disjoint with: Pharmacokinetic Effect Consequences
disjoint with: Pharmacokinetic Process
disjoint with: Public Reporting Database
disjoint with: Randomized Tx Assignment
disjoint with: Recombinant Protein System
disjoint with: Treatment Assignment
disjoint with: Xenobiotic Metabolism
disjoint with: in vitro Protein Source
disjoint with: BiochemicalReaction
disjoint with: Catalysis
disjoint with: Complex
disjoint with: ComplexAssembly
disjoint with: Control
disjoint with: Conversion
disjoint with: Degradation
disjoint with: Dna
disjoint with: DnaRegion
disjoint with: Entity
disjoint with: Gene
disjoint with: GeneticInteraction
disjoint with: Interaction
disjoint with: Modulation
disjoint with: MolecularInteraction
disjoint with: Pathway
disjoint with: PhysicalEntity
disjoint with: Protein
disjoint with: Rna
disjoint with: RnaRegion
disjoint with: SmallMolecule
disjoint with: TemplateReaction
disjoint with: TemplateReactionRegulation
disjoint with: Transport
disjoint with: TransportWithBiochemicalReaction
description: Data from a cytochrome P-450 inhibition experiment using recombinant human enzymes

EV EX Met Enz Inhibit CYP450 Human Recom Material
type: Class
subclass of: EV EX Met Enz Inhibit CYP450 Material
disjoint with: EV Observational Material
disjoint with: EV PK DDI NR Material
disjoint with: EV PK DDI Observational Material
disjoint with: EV PK DDI Par Grps Material
disjoint with: EV PK DDI RCT Material
disjoint with: EV Population PK Material
disjoint with: Enzyme
disjoint with: Increased Drug AUC
disjoint with: Increased Drug Level
disjoint with: Induction
disjoint with: Inhibition
disjoint with: Inhibitor
disjoint with: Journal Peer reviewed
disjoint with: Metabolism
disjoint with: Microsomes
disjoint with: Non randomized Tx Assignment
disjoint with: Observation based DI Report Assessment tool
disjoint with: PK DDI
disjoint with: Pharmacodynamic Effect Consequences
disjoint with: Pharmacokinetic Effect Consequences
disjoint with: Pharmacokinetic Process
disjoint with: Public Reporting Database
disjoint with: Randomized Tx Assignment
disjoint with: Recombinant Protein System
disjoint with: Treatment Assignment
disjoint with: Xenobiotic Metabolism
disjoint with: in vitro Protein Source
disjoint with: BiochemicalReaction
disjoint with: Catalysis
disjoint with: Complex
disjoint with: ComplexAssembly
disjoint with: Control
disjoint with: Conversion
disjoint with: Degradation
disjoint with: Dna
disjoint with: DnaRegion
disjoint with: Entity
disjoint with: Gene
disjoint with: GeneticInteraction
disjoint with: Interaction
disjoint with: Modulation
disjoint with: MolecularInteraction
disjoint with: Pathway
disjoint with: PhysicalEntity
disjoint with: Protein
disjoint with: Rna
disjoint with: RnaRegion
disjoint with: SmallMolecule
disjoint with: TemplateReaction
disjoint with: TemplateReactionRegulation
disjoint with: Transport
disjoint with: TransportWithBiochemicalReaction
description: Material from a cytochrome P-450 inhibition experiment using recombinant human enzymes

EV EX Met Enz Inhibit CYP450 Material
type: Class
subclass of: EV EX Met Enz Inhibit Material
disjoint with: EV Observational Material
disjoint with: EV PK DDI NR Material
disjoint with: EV PK DDI Observational Material
disjoint with: EV PK DDI Par Grps Material
disjoint with: EV PK DDI RCT Material
disjoint with: EV Population PK Material
disjoint with: Enzyme
disjoint with: Increased Drug AUC
disjoint with: Increased Drug Level
disjoint with: Induction
disjoint with: Inhibition
disjoint with: Inhibitor
disjoint with: Journal Peer reviewed
disjoint with: Metabolism
disjoint with: Microsomes
disjoint with: Non randomized Tx Assignment
disjoint with: Observation based DI Report Assessment tool
disjoint with: PK DDI
disjoint with: Pharmacodynamic Effect Consequences
disjoint with: Pharmacokinetic Effect Consequences
disjoint with: Pharmacokinetic Process
disjoint with: Public Reporting Database
disjoint with: Randomized Tx Assignment
disjoint with: Recombinant Protein System
disjoint with: Treatment Assignment
disjoint with: Xenobiotic Metabolism
disjoint with: in vitro Protein Source
disjoint with: BiochemicalReaction
disjoint with: Catalysis
disjoint with: Complex
disjoint with: ComplexAssembly
disjoint with: Control
disjoint with: Conversion
disjoint with: Degradation
disjoint with: Dna
disjoint with: DnaRegion
disjoint with: Entity
disjoint with: Gene
disjoint with: GeneticInteraction
disjoint with: Interaction
disjoint with: Modulation
disjoint with: MolecularInteraction
disjoint with: Pathway
disjoint with: PhysicalEntity
disjoint with: Protein
disjoint with: Rna
disjoint with: RnaRegion
disjoint with: SmallMolecule
disjoint with: TemplateReaction
disjoint with: TemplateReactionRegulation
disjoint with: Transport
disjoint with: TransportWithBiochemicalReaction
description: Material from a metabolic inhibition experiment specifically designed to determine whether or not a drug inhibits a specific CYP450 enzyme

EV EX Met Enz Inhibit Data
type: Class
subclass of: Evidence Type Data
disjoint with: EV Observational Data
disjoint with: EV PK DDI NR Data
disjoint with: EV PK DDI Observational Data
disjoint with: EV PK DDI Par Grps Data
disjoint with: EV PK DDI RCT Data
disjoint with: EV Population PK Data
disjoint with: Enzyme
disjoint with: Increased Drug AUC
disjoint with: Increased Drug Level
disjoint with: Induction
disjoint with: Inhibition
disjoint with: Inhibitor
disjoint with: Journal Peer reviewed
disjoint with: Metabolism
disjoint with: Microsomes
disjoint with: Non randomized Tx Assignment
disjoint with: Observation based DI Report Assessment tool
disjoint with: PK DDI
disjoint with: Pharmacodynamic Effect Consequences
disjoint with: Pharmacokinetic Effect Consequences
disjoint with: Pharmacokinetic Process
disjoint with: Public Reporting Database
disjoint with: Randomized Tx Assignment
disjoint with: Recombinant Protein System
disjoint with: Treatment Assignment
disjoint with: Xenobiotic Metabolism
disjoint with: in vitro Protein Source
disjoint with: BiochemicalReaction
disjoint with: Catalysis
disjoint with: Complex
disjoint with: ComplexAssembly
disjoint with: Control
disjoint with: Conversion
disjoint with: Degradation
disjoint with: Dna
disjoint with: DnaRegion
disjoint with: Entity
disjoint with: Gene
disjoint with: GeneticInteraction
disjoint with: Interaction
disjoint with: Modulation
disjoint with: MolecularInteraction
disjoint with: Pathway
disjoint with: PhysicalEntity
disjoint with: Protein
disjoint with: Rna
disjoint with: RnaRegion
disjoint with: SmallMolecule
disjoint with: TemplateReaction
disjoint with: TemplateReactionRegulation
disjoint with: Transport
disjoint with: TransportWithBiochemicalReaction
description: Data from an experiment conducted with biological tissues and/or chemical compounds in a laboratory designed to determine whether or not a drug inhibits a specific drug-metabolizing enzyme

EV EX Met Enz Inhibit Material
type: Class
subclass of: Evidence Type Material
disjoint with: EV Observational Material
disjoint with: EV PK DDI NR Material
disjoint with: EV PK DDI Observational Material
disjoint with: EV PK DDI Par Grps Material
disjoint with: EV PK DDI RCT Material
disjoint with: EV Population PK Material
disjoint with: Enzyme
disjoint with: Increased Drug AUC
disjoint with: Increased Drug Level
disjoint with: Induction
disjoint with: Inhibition
disjoint with: Inhibitor
disjoint with: Journal Peer reviewed
disjoint with: Metabolism
disjoint with: Microsomes
disjoint with: Non randomized Tx Assignment
disjoint with: Observation based DI Report Assessment tool
disjoint with: PK DDI
disjoint with: Pharmacodynamic Effect Consequences
disjoint with: Pharmacokinetic Effect Consequences
disjoint with: Pharmacokinetic Process
disjoint with: Public Reporting Database
disjoint with: Randomized Tx Assignment
disjoint with: Recombinant Protein System
disjoint with: Treatment Assignment
disjoint with: Xenobiotic Metabolism
disjoint with: in vitro Protein Source
disjoint with: BiochemicalReaction
disjoint with: Catalysis
disjoint with: Complex
disjoint with: ComplexAssembly
disjoint with: Control
disjoint with: Conversion
disjoint with: Degradation
disjoint with: Dna
disjoint with: DnaRegion
disjoint with: Entity
disjoint with: Gene
disjoint with: GeneticInteraction
disjoint with: Interaction
disjoint with: Modulation
disjoint with: MolecularInteraction
disjoint with: Pathway
disjoint with: PhysicalEntity
disjoint with: Protein
disjoint with: Rna
disjoint with: RnaRegion
disjoint with: SmallMolecule
disjoint with: TemplateReaction
disjoint with: TemplateReactionRegulation
disjoint with: Transport
disjoint with: TransportWithBiochemicalReaction
description: Material from an experiment conducted with biological tissues and/or chemical compounds in a laboratory designed to determine whether or not a drug inhibits a specific drug-metabolizing enzyme

EV Non Traceable Statement
type: Class
subclass of: EV Statement
disjoint with: EV Observational
disjoint with: EV PK DDI NR
disjoint with: EV PK DDI Observational
disjoint with: EV PK DDI Par Grps
disjoint with: EV PK DDI RCT
disjoint with: EV Population PK
disjoint with: EV Review
disjoint with: EV Traceable Statement
disjoint with: Enzyme
disjoint with: Increased Drug AUC
disjoint with: Increased Drug Level
disjoint with: Induction
disjoint with: Inhibition
disjoint with: Inhibitor
disjoint with: Journal Peer reviewed
disjoint with: Metabolism
disjoint with: Microsomes
disjoint with: Non randomized Tx Assignment
disjoint with: Observation based DI Report Assessment tool
disjoint with: PK DDI
disjoint with: Pharmacodynamic Effect Consequences
disjoint with: Pharmacokinetic Effect Consequences
disjoint with: Pharmacokinetic Process
disjoint with: Public Reporting Database
disjoint with: Randomized Tx Assignment
disjoint with: Recombinant Protein System
disjoint with: Treatment Assignment
disjoint with: Xenobiotic Metabolism
disjoint with: in vitro Protein Source
disjoint with: BiochemicalReaction
disjoint with: Catalysis
disjoint with: Complex
disjoint with: ComplexAssembly
disjoint with: Control
disjoint with: Conversion
disjoint with: Degradation
disjoint with: Dna
disjoint with: DnaRegion
disjoint with: Entity
disjoint with: Gene
disjoint with: GeneticInteraction
disjoint with: Interaction
disjoint with: Modulation
disjoint with: MolecularInteraction
disjoint with: Pathway
disjoint with: PhysicalEntity
disjoint with: Protein
disjoint with: Rna
disjoint with: RnaRegion
disjoint with: SmallMolecule
disjoint with: TemplateReaction
disjoint with: TemplateReactionRegulation
disjoint with: Transport
disjoint with: TransportWithBiochemicalReaction
comment: A statement that does not explicitly refer to evidence items in justification of its assertion(s)
description: A non-traceable, but possibly authoritative, statement

EV Observational
type: Class
equivalent class: Restriction
  on property: has study design
  some values from: observational study
subclass of: Evidence Type
disjoint with: EV PK DDI NR
disjoint with: EV PK DDI Par Grps
disjoint with: EV PK DDI RCT
disjoint with: EV Review
disjoint with: EV Statement
disjoint with: EV Traceable Statement
disjoint with: Enzyme
disjoint with: Increased Drug AUC
disjoint with: Increased Drug Level
disjoint with: Induction
disjoint with: Inhibition
disjoint with: Inhibitor
disjoint with: Journal Peer reviewed
disjoint with: Metabolism
disjoint with: Microsomes
disjoint with: Non randomized Tx Assignment
disjoint with: Observation based DI Report Assessment tool
disjoint with: PK DDI
disjoint with: Pharmacodynamic Effect Consequences
disjoint with: Pharmacokinetic Effect Consequences
disjoint with: Pharmacokinetic Process
disjoint with: Public Reporting Database
disjoint with: Randomized Tx Assignment
disjoint with: Recombinant Protein System
disjoint with: Treatment Assignment
disjoint with: Xenobiotic Metabolism
disjoint with: in vitro Protein Source
disjoint with: BiochemicalReaction
disjoint with: Catalysis
disjoint with: Complex
disjoint with: ComplexAssembly
disjoint with: Control
disjoint with: Conversion
disjoint with: Degradation
disjoint with: Dna
disjoint with: DnaRegion
disjoint with: Entity
disjoint with: Gene
disjoint with: GeneticInteraction
disjoint with: Interaction
disjoint with: Modulation
disjoint with: MolecularInteraction
disjoint with: Pathway
disjoint with: PhysicalEntity
disjoint with: Protein
disjoint with: Rna
disjoint with: RnaRegion
disjoint with: SmallMolecule
disjoint with: TemplateReaction
disjoint with: TemplateReactionRegulation
disjoint with: Transport
disjoint with: TransportWithBiochemicalReaction
comment: "Studies used to test etiologic hypotheses in which inferences about an exposure to putative causal factors are derived from data relating to characteristics of persons under study or to events or experiences in their past. The essential feature is that some of the persons under study have the disease or outcome of interest and their characteristics are compared with those of unaffected persons." MeSH 2007 - D012189
description: An observational study

EV Observational Data
type: Class
subclass of: Evidence Type Data
disjoint with: EV PK DDI NR Data
disjoint with: EV PK DDI Par Grps Data
disjoint with: EV PK DDI RCT Data
disjoint with: Enzyme
disjoint with: Increased Drug AUC
disjoint with: Increased Drug Level
disjoint with: Induction
disjoint with: Inhibition
disjoint with: Inhibitor
disjoint with: Journal Peer reviewed
disjoint with: Metabolism
disjoint with: Microsomes
disjoint with: Non randomized Tx Assignment
disjoint with: Observation based DI Report Assessment tool
disjoint with: PK DDI
disjoint with: Pharmacodynamic Effect Consequences
disjoint with: Pharmacokinetic Effect Consequences
disjoint with: Pharmacokinetic Process
disjoint with: Public Reporting Database
disjoint with: Randomized Tx Assignment
disjoint with: Recombinant Protein System
disjoint with: Treatment Assignment
disjoint with: Xenobiotic Metabolism
disjoint with: in vitro Protein Source
disjoint with: BiochemicalReaction
disjoint with: Catalysis
disjoint with: Complex
disjoint with: ComplexAssembly
disjoint with: Control
disjoint with: Conversion
disjoint with: Degradation
disjoint with: Dna
disjoint with: DnaRegion
disjoint with: Entity
disjoint with: Gene
disjoint with: GeneticInteraction
disjoint with: Interaction
disjoint with: Modulation
disjoint with: MolecularInteraction
disjoint with: Pathway
disjoint with: PhysicalEntity
disjoint with: Protein
disjoint with: Rna
disjoint with: RnaRegion
disjoint with: SmallMolecule
disjoint with: TemplateReaction
disjoint with: TemplateReactionRegulation
disjoint with: Transport
disjoint with: TransportWithBiochemicalReaction
description: Data from observational studies, which are defined as: "Studies used to test etiologic hypotheses in which inferences about an exposure to putative causal factors are derived from data relating to characteristics of persons under study or to events or experiences in their past. The essential feature is that some of the persons under study have the disease or outcome of interest and their characteristics are compared with those of unaffected persons." MeSH 2007 - D012189

EV Observational Material
type: Class
subclass of: Evidence Type Material
disjoint with: EV PK DDI NR Material
disjoint with: EV PK DDI Par Grps Material
disjoint with: EV PK DDI RCT Material
disjoint with: Enzyme
disjoint with: Increased Drug AUC
disjoint with: Increased Drug Level
disjoint with: Induction
disjoint with: Inhibition
disjoint with: Inhibitor
disjoint with: Journal Peer reviewed
disjoint with: Metabolism
disjoint with: Microsomes
disjoint with: Non randomized Tx Assignment
disjoint with: Observation based DI Report Assessment tool
disjoint with: PK DDI
disjoint with: Pharmacodynamic Effect Consequences
disjoint with: Pharmacokinetic Effect Consequences
disjoint with: Pharmacokinetic Process
disjoint with: Public Reporting Database
disjoint with: Randomized Tx Assignment
disjoint with: Recombinant Protein System
disjoint with: Treatment Assignment
disjoint with: Xenobiotic Metabolism
disjoint with: in vitro Protein Source
disjoint with: BiochemicalReaction
disjoint with: Catalysis
disjoint with: Complex
disjoint with: ComplexAssembly
disjoint with: Control
disjoint with: Conversion
disjoint with: Degradation
disjoint with: Dna
disjoint with: DnaRegion
disjoint with: Entity
disjoint with: Gene
disjoint with: GeneticInteraction
disjoint with: Interaction
disjoint with: Modulation
disjoint with: MolecularInteraction
disjoint with: Pathway
disjoint with: PhysicalEntity
disjoint with: Protein
disjoint with: Rna
disjoint with: RnaRegion
disjoint with: SmallMolecule
disjoint with: TemplateReaction
disjoint with: TemplateReactionRegulation
disjoint with: Transport
disjoint with: TransportWithBiochemicalReaction
description: Material from observational studies, which are defined as: "Studies used to test etiologic hypotheses in which inferences about an exposure to putative causal factors are derived from data relating to characteristics of persons under study or to events or experiences in their past. The essential feature is that some of the persons under study have the disease or outcome of interest and their characteristics are compared with those of unaffected persons." MeSH 2007 - D012189

EV PK DDI NR
type: Class
equivalent class: Class
  intersection of: EV CT PK DDI
  intersection of: Restriction
    on property: has treatment assignment method
    some values from: Non randomized Tx Assignment
  intersection of: Restriction
    on property: has treatment assignment method
    all values from: Non randomized Tx Assignment
subclass of: EV CT PK DDI
disjoint with: EV PK DDI Observational
disjoint with: EV PK DDI RCT
disjoint with: EV Population PK
disjoint with: EV Review
disjoint with: EV Statement
disjoint with: EV Traceable Statement
disjoint with: Enzyme
disjoint with: Increased Drug AUC
disjoint with: Increased Drug Level
disjoint with: Induction
disjoint with: Inhibition
disjoint with: Inhibitor
disjoint with: Journal Peer reviewed
disjoint with: Metabolism
disjoint with: Microsomes
disjoint with: Non randomized Tx Assignment
disjoint with: Observation based DI Report Assessment tool
disjoint with: PK DDI
disjoint with: Pharmacodynamic Effect Consequences
disjoint with: Pharmacokinetic Effect Consequences
disjoint with: Pharmacokinetic Process
disjoint with: Public Reporting Database
disjoint with: Randomized Tx Assignment
disjoint with: Recombinant Protein System
disjoint with: Treatment Assignment
disjoint with: Xenobiotic Metabolism
disjoint with: in vitro Protein Source
disjoint with: BiochemicalReaction
disjoint with: Catalysis
disjoint with: Complex
disjoint with: ComplexAssembly
disjoint with: Control
disjoint with: Conversion
disjoint with: Degradation
disjoint with: Dna
disjoint with: DnaRegion
disjoint with: Entity
disjoint with: Gene
disjoint with: GeneticInteraction
disjoint with: Interaction
disjoint with: Modulation
disjoint with: MolecularInteraction
disjoint with: Pathway
disjoint with: PhysicalEntity
disjoint with: Protein
disjoint with: Rna
disjoint with: RnaRegion
disjoint with: SmallMolecule
disjoint with: TemplateReaction
disjoint with: TemplateReactionRegulation
disjoint with: Transport
disjoint with: TransportWithBiochemicalReaction
comment: A pharmacokinetic study where participants receive a drug either in the presence of a purported precipitant (experimental group) or not (control group) but participants are not randomly assigned to experiment and control groups
description: A non-randomized DDI clinical trial

EV PK DDI NR Data
type: Class
subclass of: EV CT PK DDI Data
disjoint with: EV PK DDI Observational Data
disjoint with: EV Population PK Data
disjoint with: Enzyme
disjoint with: Increased Drug AUC
disjoint with: Increased Drug Level
disjoint with: Induction
disjoint with: Inhibition
disjoint with: Inhibitor
disjoint with: Journal Peer reviewed
disjoint with: Metabolism
disjoint with: Microsomes
disjoint with: Non randomized Tx Assignment
disjoint with: Observation based DI Report Assessment tool
disjoint with: PK DDI
disjoint with: Pharmacodynamic Effect Consequences
disjoint with: Pharmacokinetic Effect Consequences
disjoint with: Pharmacokinetic Process
disjoint with: Public Reporting Database
disjoint with: Randomized Tx Assignment
disjoint with: Recombinant Protein System
disjoint with: Treatment Assignment
disjoint with: Xenobiotic Metabolism
disjoint with: in vitro Protein Source
disjoint with: BiochemicalReaction
disjoint with: Catalysis
disjoint with: Complex
disjoint with: ComplexAssembly
disjoint with: Control
disjoint with: Conversion
disjoint with: Degradation
disjoint with: Dna
disjoint with: DnaRegion
disjoint with: Entity
disjoint with: Gene
disjoint with: GeneticInteraction
disjoint with: Interaction
disjoint with: Modulation
disjoint with: MolecularInteraction
disjoint with: Pathway
disjoint with: PhysicalEntity
disjoint with: Protein
disjoint with: Rna
disjoint with: RnaRegion
disjoint with: SmallMolecule
disjoint with: TemplateReaction
disjoint with: TemplateReactionRegulation
disjoint with: Transport
disjoint with: TransportWithBiochemicalReaction
description: Data from a pharmacokinetic study where participants receive a drug either in the presence of a purported precipitant (experimental group) or not (control group) but participants are not randomly assigned to experiment and control groups

EV PK DDI NR Material
type: Class
subclass of: EV CT PK DDI Material
disjoint with: EV PK DDI Observational Material
disjoint with: EV Population PK Material
disjoint with: Enzyme
disjoint with: Increased Drug AUC
disjoint with: Increased Drug Level
disjoint with: Induction
disjoint with: Inhibition
disjoint with: Inhibitor
disjoint with: Journal Peer reviewed
disjoint with: Metabolism
disjoint with: Microsomes
disjoint with: Non randomized Tx Assignment
disjoint with: Observation based DI Report Assessment tool
disjoint with: PK DDI
disjoint with: Pharmacodynamic Effect Consequences
disjoint with: Pharmacokinetic Effect Consequences
disjoint with: Pharmacokinetic Process
disjoint with: Public Reporting Database
disjoint with: Randomized Tx Assignment
disjoint with: Recombinant Protein System
disjoint with: Treatment Assignment
disjoint with: Xenobiotic Metabolism
disjoint with: in vitro Protein Source
disjoint with: BiochemicalReaction
disjoint with: Catalysis
disjoint with: Complex
disjoint with: ComplexAssembly
disjoint with: Control
disjoint with: Conversion
disjoint with: Degradation
disjoint with: Dna
disjoint with: DnaRegion
disjoint with: Entity
disjoint with: Gene
disjoint with: GeneticInteraction
disjoint with: Interaction
disjoint with: Modulation
disjoint with: MolecularInteraction
disjoint with: Pathway
disjoint with: PhysicalEntity
disjoint with: Protein
disjoint with: Rna
disjoint with: RnaRegion
disjoint with: SmallMolecule
disjoint with: TemplateReaction
disjoint with: TemplateReactionRegulation
disjoint with: Transport
disjoint with: TransportWithBiochemicalReaction
description: Material from a pharmacokinetic study where participants receive a drug either in the presence of a purported precipitant (experimental group) or not (control group) but participants are not randomly assigned to experiment and control groups

EV PK DDI Observational
type: Class
equivalent class: Class
  intersection of: EV Observational
  intersection of: Restriction
    on property: has focus of inquiry
    some values from: Pharmacokinetic Effect Consequences
  intersection of: Restriction
    on property: has focus of inquiry
    all values from: Pharmacokinetic Effect Consequences
subclass of: EV Observational
disjoint with: EV PK DDI Par Grps
disjoint with: EV PK DDI RCT
disjoint with: EV Population PK
disjoint with: EV Review
disjoint with: EV Statement
disjoint with: EV Traceable Statement
disjoint with: Enzyme
disjoint with: Increased Drug AUC
disjoint with: Increased Drug Level
disjoint with: Induction
disjoint with: Inhibition
disjoint with: Inhibitor
disjoint with: Journal Peer reviewed
disjoint with: Metabolism
disjoint with: Microsomes
disjoint with: Non randomized Tx Assignment
disjoint with: Observation based DI Report Assessment tool
disjoint with: PK DDI
disjoint with: Pharmacodynamic Effect Consequences
disjoint with: Pharmacokinetic Effect Consequences
disjoint with: Pharmacokinetic Process
disjoint with: Public Reporting Database
disjoint with: Randomized Tx Assignment
disjoint with: Recombinant Protein System
disjoint with: Treatment Assignment
disjoint with: Xenobiotic Metabolism
disjoint with: in vitro Protein Source
disjoint with: BiochemicalReaction
disjoint with: Catalysis
disjoint with: Complex
disjoint with: ComplexAssembly
disjoint with: Control
disjoint with: Conversion
disjoint with: Degradation
disjoint with: Dna
disjoint with: DnaRegion
disjoint with: Entity
disjoint with: Gene
disjoint with: GeneticInteraction
disjoint with: Interaction
disjoint with: Modulation
disjoint with: MolecularInteraction
disjoint with: Pathway
disjoint with: PhysicalEntity
disjoint with: Protein
disjoint with: Rna
disjoint with: RnaRegion
disjoint with: SmallMolecule
disjoint with: TemplateReaction
disjoint with: TemplateReactionRegulation
disjoint with: Transport
disjoint with: TransportWithBiochemicalReaction
comment: A retrospective study looking at the change in patient exposure of a single drug in the presence of a purported precipitant using a retrospective set of clinical records
description: An observational DDI study

EV PK DDI Observational Data
type: Class
subclass of: EV Observational Data
disjoint with: EV PK DDI Par Grps Data
disjoint with: EV PK DDI RCT Data
disjoint with: Enzyme
disjoint with: Increased Drug AUC
disjoint with: Increased Drug Level
disjoint with: Induction
disjoint with: Inhibition
disjoint with: Inhibitor
disjoint with: Journal Peer reviewed
disjoint with: Metabolism
disjoint with: Microsomes
disjoint with: Non randomized Tx Assignment
disjoint with: Observation based DI Report Assessment tool
disjoint with: PK DDI
disjoint with: Pharmacodynamic Effect Consequences
disjoint with: Pharmacokinetic Effect Consequences
disjoint with: Pharmacokinetic Process
disjoint with: Public Reporting Database
disjoint with: Randomized Tx Assignment
disjoint with: Recombinant Protein System
disjoint with: Treatment Assignment
disjoint with: Xenobiotic Metabolism
disjoint with: in vitro Protein Source
disjoint with: BiochemicalReaction
disjoint with: Catalysis
disjoint with: Complex
disjoint with: ComplexAssembly
disjoint with: Control
disjoint with: Conversion
disjoint with: Degradation
disjoint with: Dna
disjoint with: DnaRegion
disjoint with: Entity
disjoint with: Gene
disjoint with: GeneticInteraction
disjoint with: Interaction
disjoint with: Modulation
disjoint with: MolecularInteraction
disjoint with: Pathway
disjoint with: PhysicalEntity
disjoint with: Protein
disjoint with: Rna
disjoint with: RnaRegion
disjoint with: SmallMolecule
disjoint with: TemplateReaction
disjoint with: TemplateReactionRegulation
disjoint with: Transport
disjoint with: TransportWithBiochemicalReaction
description: Data from a retrospective study looking at the change in patient exposure of a single drug in the presence of a purported precipitant using a retrospective set of clinical records

EV PK DDI Observational Material
type: Class
subclass of: EV Observational Material
disjoint with: EV PK DDI Par Grps Material
disjoint with: EV PK DDI RCT Material
disjoint with: Enzyme
disjoint with: Increased Drug AUC
disjoint with: Increased Drug Level
disjoint with: Induction
disjoint with: Inhibition
disjoint with: Inhibitor
disjoint with: Journal Peer reviewed
disjoint with: Metabolism
disjoint with: Microsomes
disjoint with: Non randomized Tx Assignment
disjoint with: Observation based DI Report Assessment tool
disjoint with: PK DDI
disjoint with: Pharmacodynamic Effect Consequences
disjoint with: Pharmacokinetic Effect Consequences
disjoint with: Pharmacokinetic Process
disjoint with: Public Reporting Database
disjoint with: Randomized Tx Assignment
disjoint with: Recombinant Protein System
disjoint with: Treatment Assignment
disjoint with: Xenobiotic Metabolism
disjoint with: in vitro Protein Source
disjoint with: BiochemicalReaction
disjoint with: Catalysis
disjoint with: Complex
disjoint with: ComplexAssembly
disjoint with: Control
disjoint with: Conversion
disjoint with: Degradation
disjoint with: Dna
disjoint with: DnaRegion
disjoint with: Entity
disjoint with: Gene
disjoint with: GeneticInteraction
disjoint with: Interaction
disjoint with: Modulation
disjoint with: MolecularInteraction
disjoint with: Pathway
disjoint with: PhysicalEntity
disjoint with: Protein
disjoint with: Rna
disjoint with: RnaRegion
disjoint with: SmallMolecule
disjoint with: TemplateReaction
disjoint with: TemplateReactionRegulation
disjoint with: Transport
disjoint with: TransportWithBiochemicalReaction
description: Material from a retrospective study looking at the change in patient exposure of a single drug in the presence of a purported precipitant using a retrospective set of clinical records

EV PK DDI Par Grps
type: Class
equivalent class: Class
  intersection of: EV PK DDI NR
  intersection of: Restriction
    on property: has treatment assignment method
    has value: Parallel groups assignment
subclass of: EV PK DDI NR
disjoint with: EV PK DDI RCT
disjoint with: EV Population PK
disjoint with: EV Review
disjoint with: EV Statement
disjoint with: EV Traceable Statement
disjoint with: Enzyme
disjoint with: Increased Drug AUC
disjoint with: Increased Drug Level
disjoint with: Induction
disjoint with: Inhibition
disjoint with: Inhibitor
disjoint with: Journal Peer reviewed
disjoint with: Metabolism
disjoint with: Microsomes
disjoint with: Non randomized Tx Assignment
disjoint with: Observation based DI Report Assessment tool
disjoint with: PK DDI
disjoint with: Pharmacodynamic Effect Consequences
disjoint with: Pharmacokinetic Effect Consequences
disjoint with: Pharmacokinetic Process
disjoint with: Public Reporting Database
disjoint with: Randomized Tx Assignment
disjoint with: Recombinant Protein System
disjoint with: Treatment Assignment
disjoint with: Xenobiotic Metabolism
disjoint with: in vitro Protein Source
disjoint with: BiochemicalReaction
disjoint with: Catalysis
disjoint with: Complex
disjoint with: ComplexAssembly
disjoint with: Control
disjoint with: Conversion
disjoint with: Degradation
disjoint with: Dna
disjoint with: DnaRegion
disjoint with: Entity
disjoint with: Gene
disjoint with: GeneticInteraction
disjoint with: Interaction
disjoint with: Modulation
disjoint with: MolecularInteraction
disjoint with: Pathway
disjoint with: PhysicalEntity
disjoint with: Protein
disjoint with: Rna
disjoint with: RnaRegion
disjoint with: SmallMolecule
disjoint with: TemplateReaction
disjoint with: TemplateReactionRegulation
disjoint with: Transport
disjoint with: TransportWithBiochemicalReaction
comment: A pharmacokinetic study involving two groups of non-randomized participants where both groups recieve the purported object drug while only one group receives the purported precipitant
description: A parallel groups DDI clinical trial

EV PK DDI Par Grps Data
type: Class
subclass of: EV PK DDI NR Data
disjoint with: EV Population PK Data
disjoint with: Enzyme
disjoint with: Increased Drug AUC
disjoint with: Increased Drug Level
disjoint with: Induction
disjoint with: Inhibition
disjoint with: Inhibitor
disjoint with: Journal Peer reviewed
disjoint with: Metabolism
disjoint with: Microsomes
disjoint with: Non randomized Tx Assignment
disjoint with: Observation based DI Report Assessment tool
disjoint with: PK DDI
disjoint with: Pharmacodynamic Effect Consequences
disjoint with: Pharmacokinetic Effect Consequences
disjoint with: Pharmacokinetic Process
disjoint with: Public Reporting Database
disjoint with: Randomized Tx Assignment
disjoint with: Recombinant Protein System
disjoint with: Treatment Assignment
disjoint with: Xenobiotic Metabolism
disjoint with: in vitro Protein Source
disjoint with: BiochemicalReaction
disjoint with: Catalysis
disjoint with: Complex
disjoint with: ComplexAssembly
disjoint with: Control
disjoint with: Conversion
disjoint with: Degradation
disjoint with: Dna
disjoint with: DnaRegion
disjoint with: Entity
disjoint with: Gene
disjoint with: GeneticInteraction
disjoint with: Interaction
disjoint with: Modulation
disjoint with: MolecularInteraction
disjoint with: Pathway
disjoint with: PhysicalEntity
disjoint with: Protein
disjoint with: Rna
disjoint with: RnaRegion
disjoint with: SmallMolecule
disjoint with: TemplateReaction
disjoint with: TemplateReactionRegulation
disjoint with: Transport
disjoint with: TransportWithBiochemicalReaction
description: Data from a pharmacokinetic study involving two groups of non-randomized participants where both groups recieve the purported object drug while only one group receives the purported precipitant

EV PK DDI Par Grps Material
type: Class
subclass of: EV PK DDI NR Material
disjoint with: EV Population PK Material
disjoint with: Enzyme
disjoint with: Increased Drug AUC
disjoint with: Increased Drug Level
disjoint with: Induction
disjoint with: Inhibition
disjoint with: Inhibitor
disjoint with: Journal Peer reviewed
disjoint with: Metabolism
disjoint with: Microsomes
disjoint with: Non randomized Tx Assignment
disjoint with: Observation based DI Report Assessment tool
disjoint with: PK DDI
disjoint with: Pharmacodynamic Effect Consequences
disjoint with: Pharmacokinetic Effect Consequences
disjoint with: Pharmacokinetic Process
disjoint with: Public Reporting Database
disjoint with: Randomized Tx Assignment
disjoint with: Recombinant Protein System
disjoint with: Treatment Assignment
disjoint with: Xenobiotic Metabolism
disjoint with: in vitro Protein Source
disjoint with: BiochemicalReaction
disjoint with: Catalysis
disjoint with: Complex
disjoint with: ComplexAssembly
disjoint with: Control
disjoint with: Conversion
disjoint with: Degradation
disjoint with: Dna
disjoint with: DnaRegion
disjoint with: Entity
disjoint with: Gene
disjoint with: GeneticInteraction
disjoint with: Interaction
disjoint with: Modulation
disjoint with: MolecularInteraction
disjoint with: Pathway
disjoint with: PhysicalEntity
disjoint with: Protein
disjoint with: Rna
disjoint with: RnaRegion
disjoint with: SmallMolecule
disjoint with: TemplateReaction
disjoint with: TemplateReactionRegulation
disjoint with: Transport
disjoint with: TransportWithBiochemicalReaction
description: Material from a pharmacokinetic study involving two groups of non-randomized participants where both groups recieve the purported object drug while only one group receives the purported precipitant

EV PK DDI RCT
type: Class
equivalent class: Class
  intersection of: EV CT PK DDI
  intersection of: Restriction
    on property: has treatment assignment method
    some values from: Randomized Tx Assignment
  intersection of: Restriction
    on property: has treatment assignment method
    all values from: Randomized Tx Assignment
subclass of: EV CT PK DDI
disjoint with: EV Population PK
disjoint with: EV Review
disjoint with: EV Statement
disjoint with: EV Traceable Statement
disjoint with: Enzyme
disjoint with: Increased Drug AUC
disjoint with: Increased Drug Level
disjoint with: Induction
disjoint with: Inhibition
disjoint with: Inhibitor
disjoint with: Journal Peer reviewed
disjoint with: Metabolism
disjoint with: Microsomes
disjoint with: Non randomized Tx Assignment
disjoint with: Observation based DI Report Assessment tool
disjoint with: PK DDI
disjoint with: Pharmacodynamic Effect Consequences
disjoint with: Pharmacokinetic Effect Consequences
disjoint with: Pharmacokinetic Process
disjoint with: Public Reporting Database
disjoint with: Randomized Tx Assignment
disjoint with: Recombinant Protein System
disjoint with: Treatment Assignment
disjoint with: Xenobiotic Metabolism
disjoint with: in vitro Protein Source
disjoint with: BiochemicalReaction
disjoint with: Catalysis
disjoint with: Complex
disjoint with: ComplexAssembly
disjoint with: Control
disjoint with: Conversion
disjoint with: Degradation
disjoint with: Dna
disjoint with: DnaRegion
disjoint with: Entity
disjoint with: Gene
disjoint with: GeneticInteraction
disjoint with: Interaction
disjoint with: Modulation
disjoint with: MolecularInteraction
disjoint with: Pathway
disjoint with: PhysicalEntity
disjoint with: Protein
disjoint with: Rna
disjoint with: RnaRegion
disjoint with: SmallMolecule
disjoint with: TemplateReaction
disjoint with: TemplateReactionRegulation
disjoint with: Transport
disjoint with: TransportWithBiochemicalReaction
comment: A randomized, controlled, pharmacokinetic study where participants receive a drug wither in the presence of a purported precipitant (experimental group) or not (control group)
description: A randomized DDI clinical trial

EV PK DDI RCT Data
type: Class
subclass of: EV CT PK DDI Data
disjoint with: EV Population PK Data
disjoint with: Enzyme
disjoint with: Increased Drug AUC
disjoint with: Increased Drug Level
disjoint with: Induction
disjoint with: Inhibition
disjoint with: Inhibitor
disjoint with: Journal Peer reviewed
disjoint with: Metabolism
disjoint with: Microsomes
disjoint with: Non randomized Tx Assignment
disjoint with: Observation based DI Report Assessment tool
disjoint with: PK DDI
disjoint with: Pharmacodynamic Effect Consequences
disjoint with: Pharmacokinetic Effect Consequences
disjoint with: Pharmacokinetic Process
disjoint with: Public Reporting Database
disjoint with: Randomized Tx Assignment
disjoint with: Recombinant Protein System
disjoint with: Treatment Assignment
disjoint with: Xenobiotic Metabolism
disjoint with: in vitro Protein Source
disjoint with: BiochemicalReaction
disjoint with: Catalysis
disjoint with: Complex
disjoint with: ComplexAssembly
disjoint with: Control
disjoint with: Conversion
disjoint with: Degradation
disjoint with: Dna
disjoint with: DnaRegion
disjoint with: Entity
disjoint with: Gene
disjoint with: GeneticInteraction
disjoint with: Interaction
disjoint with: Modulation
disjoint with: MolecularInteraction
disjoint with: Pathway
disjoint with: PhysicalEntity
disjoint with: Protein
disjoint with: Rna
disjoint with: RnaRegion
disjoint with: SmallMolecule
disjoint with: TemplateReaction
disjoint with: TemplateReactionRegulation
disjoint with: Transport
disjoint with: TransportWithBiochemicalReaction
description: Data from a randomized, controlled, pharmacokinetic study where participants receive a drug wither in the presence of a purported precipitant (experimental group) or not (control group)

EV PK DDI RCT Material
type: Class
subclass of: EV CT PK DDI Material
disjoint with: EV Population PK Material
disjoint with: Enzyme
disjoint with: Increased Drug AUC
disjoint with: Increased Drug Level
disjoint with: Induction
disjoint with: Inhibition
disjoint with: Inhibitor
disjoint with: Journal Peer reviewed
disjoint with: Metabolism
disjoint with: Microsomes
disjoint with: Non randomized Tx Assignment
disjoint with: Observation based DI Report Assessment tool
disjoint with: PK DDI
disjoint with: Pharmacodynamic Effect Consequences
disjoint with: Pharmacokinetic Effect Consequences
disjoint with: Pharmacokinetic Process
disjoint with: Public Reporting Database
disjoint with: Randomized Tx Assignment
disjoint with: Recombinant Protein System
disjoint with: Treatment Assignment
disjoint with: Xenobiotic Metabolism
disjoint with: in vitro Protein Source
disjoint with: BiochemicalReaction
disjoint with: Catalysis
disjoint with: Complex
disjoint with: ComplexAssembly
disjoint with: Control
disjoint with: Conversion
disjoint with: Degradation
disjoint with: Dna
disjoint with: DnaRegion
disjoint with: Entity
disjoint with: Gene
disjoint with: GeneticInteraction
disjoint with: Interaction
disjoint with: Modulation
disjoint with: MolecularInteraction
disjoint with: Pathway
disjoint with: PhysicalEntity
disjoint with: Protein
disjoint with: Rna
disjoint with: RnaRegion
disjoint with: SmallMolecule
disjoint with: TemplateReaction
disjoint with: TemplateReactionRegulation
disjoint with: Transport
disjoint with: TransportWithBiochemicalReaction
description: Material from a randomized, controlled, pharmacokinetic study where participants receive a drug wither in the presence of a purported precipitant (experimental group) or not (control group)

EV Population PK
type: Class
equivalent class: Class
  intersection of: EV Observational
  intersection of: Restriction
    on property: has focus of inquiry
    some values from: Pharmacokinetic Process
  intersection of: Restriction
    on property: has focus of inquiry
    all values from: Pharmacokinetic Process
subclass of: EV Observational
disjoint with: EV Review
disjoint with: EV Statement
disjoint with: EV Traceable Statement
disjoint with: Enzyme
disjoint with: Increased Drug AUC
disjoint with: Increased Drug Level
disjoint with: Induction
disjoint with: Inhibition
disjoint with: Inhibitor
disjoint with: Journal Peer reviewed
disjoint with: Metabolism
disjoint with: Microsomes
disjoint with: Non randomized Tx Assignment
disjoint with: Observation based DI Report Assessment tool
disjoint with: PK DDI
disjoint with: Pharmacodynamic Effect Consequences
disjoint with: Pharmacokinetic Effect Consequences
disjoint with: Pharmacokinetic Process
disjoint with: Public Reporting Database
disjoint with: Randomized Tx Assignment
disjoint with: Recombinant Protein System
disjoint with: Treatment Assignment
disjoint with: Xenobiotic Metabolism
disjoint with: in vitro Protein Source
disjoint with: BiochemicalReaction
disjoint with: Catalysis
disjoint with: Complex
disjoint with: ComplexAssembly
disjoint with: Control
disjoint with: Conversion
disjoint with: Degradation
disjoint with: Dna
disjoint with: DnaRegion
disjoint with: Entity
disjoint with: Gene
disjoint with: GeneticInteraction
disjoint with: Interaction
disjoint with: Modulation
disjoint with: MolecularInteraction
disjoint with: Pathway
disjoint with: PhysicalEntity
disjoint with: Protein
disjoint with: Rna
disjoint with: RnaRegion
disjoint with: SmallMolecule
disjoint with: TemplateReaction
disjoint with: TemplateReactionRegulation
disjoint with: Transport
disjoint with: TransportWithBiochemicalReaction
comment: a ``...study of the sources and correlates of variability in drug concentrations among individuals who are the target patient population receiving clinically relevant doses of a drug in question.'' (\cite{fda1999b}, p.1)
description: An observational population PK study

EV Population PK Data
type: Class
subclass of: EV Observational Data
disjoint with: Enzyme
disjoint with: Increased Drug AUC
disjoint with: Increased Drug Level
disjoint with: Induction
disjoint with: Inhibition
disjoint with: Inhibitor
disjoint with: Journal Peer reviewed
disjoint with: Metabolism
disjoint with: Microsomes
disjoint with: Non randomized Tx Assignment
disjoint with: Observation based DI Report Assessment tool
disjoint with: PK DDI
disjoint with: Pharmacodynamic Effect Consequences
disjoint with: Pharmacokinetic Effect Consequences
disjoint with: Pharmacokinetic Process
disjoint with: Public Reporting Database
disjoint with: Randomized Tx Assignment
disjoint with: Recombinant Protein System
disjoint with: Treatment Assignment
disjoint with: Xenobiotic Metabolism
disjoint with: in vitro Protein Source
disjoint with: BiochemicalReaction
disjoint with: Catalysis
disjoint with: Complex
disjoint with: ComplexAssembly
disjoint with: Control
disjoint with: Conversion
disjoint with: Degradation
disjoint with: Dna
disjoint with: DnaRegion
disjoint with: Entity
disjoint with: Gene
disjoint with: GeneticInteraction
disjoint with: Interaction
disjoint with: Modulation
disjoint with: MolecularInteraction
disjoint with: Pathway
disjoint with: PhysicalEntity
disjoint with: Protein
disjoint with: Rna
disjoint with: RnaRegion
disjoint with: SmallMolecule
disjoint with: TemplateReaction
disjoint with: TemplateReactionRegulation
disjoint with: Transport
disjoint with: TransportWithBiochemicalReaction
description: Data from a "...study of the sources and correlates of variability in drug concentrations among individuals who are the target patient population receiving clinically relevant doses of a drug in question.'' (fda1999b, p.1)

EV Population PK Material
type: Class
subclass of: EV Observational Material
disjoint with: Enzyme
disjoint with: Increased Drug AUC
disjoint with: Increased Drug Level
disjoint with: Induction
disjoint with: Inhibition
disjoint with: Inhibitor
disjoint with: Journal Peer reviewed
disjoint with: Metabolism
disjoint with: Microsomes
disjoint with: Non randomized Tx Assignment
disjoint with: Observation based DI Report Assessment tool
disjoint with: PK DDI
disjoint with: Pharmacodynamic Effect Consequences
disjoint with: Pharmacokinetic Effect Consequences
disjoint with: Pharmacokinetic Process
disjoint with: Public Reporting Database
disjoint with: Randomized Tx Assignment
disjoint with: Recombinant Protein System
disjoint with: Treatment Assignment
disjoint with: Xenobiotic Metabolism
disjoint with: in vitro Protein Source
disjoint with: BiochemicalReaction
disjoint with: Catalysis
disjoint with: Complex
disjoint with: ComplexAssembly
disjoint with: Control
disjoint with: Conversion
disjoint with: Degradation
disjoint with: Dna
disjoint with: DnaRegion
disjoint with: Entity
disjoint with: Gene
disjoint with: GeneticInteraction
disjoint with: Interaction
disjoint with: Modulation
disjoint with: MolecularInteraction
disjoint with: Pathway
disjoint with: PhysicalEntity
disjoint with: Protein
disjoint with: Rna
disjoint with: RnaRegion
disjoint with: SmallMolecule
disjoint with: TemplateReaction
disjoint with: TemplateReactionRegulation
disjoint with: Transport
disjoint with: TransportWithBiochemicalReaction
description: Material from a "...study of the sources and correlates of variability in drug concentrations among individuals who are the target patient population receiving clinically relevant doses of a drug in question.'' (fda1999b, p.1)

EV Review
type: Class
equivalent class: Restriction
  on property: has study design
  some values from: literature review
subclass of: Evidence Type
disjoint with: EV Statement
disjoint with: EV Traceable Statement
disjoint with: Enzyme
disjoint with: Increased Drug AUC
disjoint with: Increased Drug Level
disjoint with: Induction
disjoint with: Inhibition
disjoint with: Inhibitor
disjoint with: Journal Peer reviewed
disjoint with: Metabolism
disjoint with: Microsomes
disjoint with: Non randomized Tx Assignment
disjoint with: Observation based DI Report Assessment tool
disjoint with: PK DDI
disjoint with: Pharmacodynamic Effect Consequences
disjoint with: Pharmacokinetic Effect Consequences
disjoint with: Pharmacokinetic Process
disjoint with: Public Reporting Database
disjoint with: Randomized Tx Assignment
disjoint with: Recombinant Protein System
disjoint with: Treatment Assignment
disjoint with: Xenobiotic Metabolism
disjoint with: in vitro Protein Source
disjoint with: BiochemicalReaction
disjoint with: Catalysis
disjoint with: Complex
disjoint with: ComplexAssembly
disjoint with: Control
disjoint with: Conversion
disjoint with: Degradation
disjoint with: Dna
disjoint with: DnaRegion
disjoint with: Entity
disjoint with: Gene
disjoint with: GeneticInteraction
disjoint with: Interaction
disjoint with: Modulation
disjoint with: MolecularInteraction
disjoint with: Pathway
disjoint with: PhysicalEntity
disjoint with: Protein
disjoint with: Rna
disjoint with: RnaRegion
disjoint with: SmallMolecule
disjoint with: TemplateReaction
disjoint with: TemplateReactionRegulation
disjoint with: Transport
disjoint with: TransportWithBiochemicalReaction
comment: A published analysis of the evidence supportin and/or refuting some topic
description: A review article

EV Statement
type: Class
subclass of: QualifiedStatement
subclass of: Evidence Type
disjoint with: Enzyme
disjoint with: Increased Drug AUC
disjoint with: Increased Drug Level
disjoint with: Induction
disjoint with: Inhibition
disjoint with: Inhibitor
disjoint with: Journal Peer reviewed
disjoint with: Metabolism
disjoint with: Microsomes
disjoint with: Non randomized Tx Assignment
disjoint with: Observation based DI Report Assessment tool
disjoint with: PK DDI
disjoint with: Pharmacodynamic Effect Consequences
disjoint with: Pharmacokinetic Effect Consequences
disjoint with: Pharmacokinetic Process
disjoint with: Public Reporting Database
disjoint with: Randomized Tx Assignment
disjoint with: Recombinant Protein System
disjoint with: Treatment Assignment
disjoint with: Xenobiotic Metabolism
disjoint with: in vitro Protein Source
disjoint with: BiochemicalReaction
disjoint with: Catalysis
disjoint with: Complex
disjoint with: ComplexAssembly
disjoint with: Control
disjoint with: Conversion
disjoint with: Degradation
disjoint with: Dna
disjoint with: DnaRegion
disjoint with: Entity
disjoint with: Gene
disjoint with: GeneticInteraction
disjoint with: Interaction
disjoint with: Modulation
disjoint with: MolecularInteraction
disjoint with: Pathway
disjoint with: PhysicalEntity
disjoint with: Protein
disjoint with: Rna
disjoint with: RnaRegion
disjoint with: SmallMolecule
disjoint with: TemplateReaction
disjoint with: TemplateReactionRegulation
disjoint with: Transport
disjoint with: TransportWithBiochemicalReaction
comment: "a message that is stated or declared; a communication (oral or written) setting forth particulars or facts etc" Wordnet v2.1
description: A statement

EV Traceable Statement
type: Class
subclass of: ReferencedStatement
subclass of: EV Statement
disjoint with: Enzyme
disjoint with: Increased Drug AUC
disjoint with: Increased Drug Level
disjoint with: Induction
disjoint with: Inhibition
disjoint with: Inhibitor
disjoint with: Journal Peer reviewed
disjoint with: Metabolism
disjoint with: Microsomes
disjoint with: Non randomized Tx Assignment
disjoint with: Observation based DI Report Assessment tool
disjoint with: PK DDI
disjoint with: Pharmacodynamic Effect Consequences
disjoint with: Pharmacokinetic Effect Consequences
disjoint with: Pharmacokinetic Process
disjoint with: Public Reporting Database
disjoint with: Randomized Tx Assignment
disjoint with: Recombinant Protein System
disjoint with: Treatment Assignment
disjoint with: Xenobiotic Metabolism
disjoint with: in vitro Protein Source
disjoint with: BiochemicalReaction
disjoint with: Catalysis
disjoint with: Complex
disjoint with: ComplexAssembly
disjoint with: Control
disjoint with: Conversion
disjoint with: Degradation
disjoint with: Dna
disjoint with: DnaRegion
disjoint with: Entity
disjoint with: Gene
disjoint with: GeneticInteraction
disjoint with: Interaction
disjoint with: Modulation
disjoint with: MolecularInteraction
disjoint with: Pathway
disjoint with: PhysicalEntity
disjoint with: Protein
disjoint with: Rna
disjoint with: RnaRegion
disjoint with: SmallMolecule
disjoint with: TemplateReaction
disjoint with: TemplateReactionRegulation
disjoint with: Transport
disjoint with: TransportWithBiochemicalReaction
comment: A statement that provides citation to evidence support for justification of its assertion(s)
description: A traceable statement

Enzyme
type: Class
subclass of: PhysicalEntity
disjoint with: Evidence Type
disjoint with: Evidence Type Data
disjoint with: Evidence Type Material
disjoint with: Induction
disjoint with: Inhibition
disjoint with: Journal Peer reviewed
disjoint with: Microsomes
disjoint with: Non randomized Tx Assignment
disjoint with: Observation based DI Report Assessment tool
disjoint with: PK DDI
disjoint with: Public Reporting Database
disjoint with: Randomized Tx Assignment
disjoint with: Recombinant Protein System
disjoint with: Treatment Assignment
disjoint with: in vitro Protein Source
disjoint with: BindingFeature
disjoint with: BioSource
disjoint with: BiochemicalPathwayStep
disjoint with: BiochemicalReaction
disjoint with: Catalysis
disjoint with: CellVocabulary
disjoint with: CellularLocationVocabulary
disjoint with: ChemicalStructure
disjoint with: Complex
disjoint with: ComplexAssembly
disjoint with: Control
disjoint with: ControlledVocabulary
disjoint with: Conversion
disjoint with: CovalentBindingFeature
disjoint with: Degradation
disjoint with: DeltaG
disjoint with: Dna
disjoint with: DnaReference
disjoint with: DnaRegionReference
disjoint with: EntityFeature
disjoint with: EntityReference
disjoint with: EntityReferenceTypeVocabulary
disjoint with: Evidence
disjoint with: EvidenceCodeVocabulary
disjoint with: ExperimentalForm
disjoint with: ExperimentalFormVocabulary
disjoint with: FragmentFeature
disjoint with: Gene
disjoint with: GeneticInteraction
disjoint with: Interaction
disjoint with: InteractionVocabulary
disjoint with: KPrime
disjoint with: ModificationFeature
disjoint with: Modulation
disjoint with: MolecularInteraction
disjoint with: Pathway
disjoint with: PathwayStep
disjoint with: PhenotypeVocabulary
disjoint with: ProteinReference
disjoint with: Provenance
disjoint with: PublicationXref
disjoint with: RelationshipTypeVocabulary
disjoint with: RelationshipXref
disjoint with: Rna
disjoint with: RnaReference
disjoint with: RnaRegionReference
disjoint with: Score
disjoint with: SequenceInterval
disjoint with: SequenceLocation
disjoint with: SequenceModificationVocabulary
disjoint with: SequenceRegionVocabulary
disjoint with: SequenceSite
disjoint with: SmallMolecule
disjoint with: SmallMoleculeReference
disjoint with: Stoichiometry
disjoint with: TemplateReaction
disjoint with: TemplateReactionRegulation
disjoint with: TissueVocabulary
disjoint with: Transport
disjoint with: TransportWithBiochemicalReaction
disjoint with: UnificationXref
disjoint with: UtilityClass
disjoint with: Xref

Evidence Type
type: Class
subclass of: Thing
disjoint with: Increased Drug AUC
disjoint with: Increased Drug Level
disjoint with: Induction
disjoint with: Inhibition
disjoint with: Inhibitor
disjoint with: Journal Peer reviewed
disjoint with: Metabolism
disjoint with: Microsomes
disjoint with: Non randomized Tx Assignment
disjoint with: Observation based DI Report Assessment tool
disjoint with: PK DDI
disjoint with: Pharmacodynamic Effect Consequences
disjoint with: Pharmacokinetic Effect Consequences
disjoint with: Pharmacokinetic Process
disjoint with: Public Reporting Database
disjoint with: Randomized Tx Assignment
disjoint with: Recombinant Protein System
disjoint with: Treatment Assignment
disjoint with: Xenobiotic Metabolism
disjoint with: in vitro Protein Source
disjoint with: BiochemicalReaction
disjoint with: Catalysis
disjoint with: Complex
disjoint with: ComplexAssembly
disjoint with: Control
disjoint with: Conversion
disjoint with: Degradation
disjoint with: Dna
disjoint with: DnaRegion
disjoint with: Entity
disjoint with: Gene
disjoint with: GeneticInteraction
disjoint with: Interaction
disjoint with: Modulation
disjoint with: MolecularInteraction
disjoint with: Pathway
disjoint with: PhysicalEntity
disjoint with: Protein
disjoint with: Rna
disjoint with: RnaRegion
disjoint with: SmallMolecule
disjoint with: TemplateReaction
disjoint with: TemplateReactionRegulation
disjoint with: Transport
disjoint with: TransportWithBiochemicalReaction
comment: a kind of evidence where evidence is defined as an artifact that is "...the basis for belief or disbelief; knowledge on which to base belief" see "evidence" in Wordnet 2.1

Evidence Type Data
type: Class
subclass of: Thing
disjoint with: Increased Drug AUC
disjoint with: Increased Drug Level
disjoint with: Induction
disjoint with: Inhibition
disjoint with: Inhibitor
disjoint with: Journal Peer reviewed
disjoint with: Metabolism
disjoint with: Microsomes
disjoint with: Non randomized Tx Assignment
disjoint with: Observation based DI Report Assessment tool
disjoint with: PK DDI
disjoint with: Pharmacodynamic Effect Consequences
disjoint with: Pharmacokinetic Effect Consequences
disjoint with: Pharmacokinetic Process
disjoint with: Public Reporting Database
disjoint with: Randomized Tx Assignment
disjoint with: Recombinant Protein System
disjoint with: Treatment Assignment
disjoint with: Xenobiotic Metabolism
disjoint with: in vitro Protein Source
disjoint with: BiochemicalReaction
disjoint with: Catalysis
disjoint with: Complex
disjoint with: ComplexAssembly
disjoint with: Control
disjoint with: Conversion
disjoint with: Degradation
disjoint with: Dna
disjoint with: DnaRegion
disjoint with: Entity
disjoint with: Gene
disjoint with: GeneticInteraction
disjoint with: Interaction
disjoint with: Modulation
disjoint with: MolecularInteraction
disjoint with: Pathway
disjoint with: PhysicalEntity
disjoint with: Protein
disjoint with: Rna
disjoint with: RnaRegion
disjoint with: SmallMolecule
disjoint with: TemplateReaction
disjoint with: TemplateReactionRegulation
disjoint with: Transport
disjoint with: TransportWithBiochemicalReaction
description: a kind of data from a specific type of evidence where data is defined as an artifact that is "an item of factual information derived from measurement or research" see "data" in Wordnet 3.1

Evidence Type Material
type: Class
subclass of: Thing
disjoint with: Increased Drug AUC
disjoint with: Increased Drug Level
disjoint with: Induction
disjoint with: Inhibition
disjoint with: Inhibitor
disjoint with: Journal Peer reviewed
disjoint with: Metabolism
disjoint with: Microsomes
disjoint with: Non randomized Tx Assignment
disjoint with: Observation based DI Report Assessment tool
disjoint with: PK DDI
disjoint with: Pharmacodynamic Effect Consequences
disjoint with: Pharmacokinetic Effect Consequences
disjoint with: Pharmacokinetic Process
disjoint with: Public Reporting Database
disjoint with: Randomized Tx Assignment
disjoint with: Recombinant Protein System
disjoint with: Treatment Assignment
disjoint with: Xenobiotic Metabolism
disjoint with: in vitro Protein Source
disjoint with: BiochemicalReaction
disjoint with: Catalysis
disjoint with: Complex
disjoint with: ComplexAssembly
disjoint with: Control
disjoint with: Conversion
disjoint with: Degradation
disjoint with: Dna
disjoint with: DnaRegion
disjoint with: Entity
disjoint with: Gene
disjoint with: GeneticInteraction
disjoint with: Interaction
disjoint with: Modulation
disjoint with: MolecularInteraction
disjoint with: Pathway
disjoint with: PhysicalEntity
disjoint with: Protein
disjoint with: Rna
disjoint with: RnaRegion
disjoint with: SmallMolecule
disjoint with: TemplateReaction
disjoint with: TemplateReactionRegulation
disjoint with: Transport
disjoint with: TransportWithBiochemicalReaction
description: a kind of material from a specific type of evidence where a material is defined as an artifact that is "things needed for doing or making something" see "material" in Wordnet 3.1

Increased Drug AUC
type: Class
subclass of: Increased Drug Level
disjoint with: Journal Peer reviewed
disjoint with: Metabolism
disjoint with: Microsomes
disjoint with: Non randomized Tx Assignment
disjoint with: Observation based DI Report Assessment tool
disjoint with: PK DDI
disjoint with: Pharmacodynamic Effect Consequences
disjoint with: Pharmacokinetic Process
disjoint with: Public Reporting Database
disjoint with: Randomized Tx Assignment
disjoint with: Recombinant Protein System
disjoint with: Treatment Assignment
disjoint with: Xenobiotic Metabolism
disjoint with: in vitro Protein Source
disjoint with: BindingFeature
disjoint with: BioSource
disjoint with: BiochemicalPathwayStep
disjoint with: CellVocabulary
disjoint with: CellularLocationVocabulary
disjoint with: ChemicalStructure
disjoint with: ControlledVocabulary
disjoint with: CovalentBindingFeature
disjoint with: DeltaG
disjoint with: DnaReference
disjoint with: DnaRegionReference
disjoint with: EntityFeature
disjoint with: EntityReference
disjoint with: EntityReferenceTypeVocabulary
disjoint with: Evidence
disjoint with: EvidenceCodeVocabulary
disjoint with: ExperimentalForm
disjoint with: ExperimentalFormVocabulary
disjoint with: FragmentFeature
disjoint with: InteractionVocabulary
disjoint with: KPrime
disjoint with: ModificationFeature
disjoint with: PathwayStep
disjoint with: PhenotypeVocabulary
disjoint with: ProteinReference
disjoint with: Provenance
disjoint with: PublicationXref
disjoint with: RelationshipTypeVocabulary
disjoint with: RelationshipXref
disjoint with: RnaReference
disjoint with: RnaRegionReference
disjoint with: Score
disjoint with: SequenceInterval
disjoint with: SequenceLocation
disjoint with: SequenceModificationVocabulary
disjoint with: SequenceRegionVocabulary
disjoint with: SequenceSite
disjoint with: SmallMoleculeReference
disjoint with: Stoichiometry
disjoint with: TissueVocabulary
disjoint with: UnificationXref
disjoint with: UtilityClass
disjoint with: Xref
comment: Increased area under the plot of plasma concentration of a drug against time after drug administration. NCI C54605

Increased Drug Level
type: Class
subclass of: Pharmacokinetic Effect Consequences
disjoint with: Journal Peer reviewed
disjoint with: Metabolism
disjoint with: Microsomes
disjoint with: Non randomized Tx Assignment
disjoint with: Observation based DI Report Assessment tool
disjoint with: PK DDI
disjoint with: Pharmacodynamic Effect Consequences
disjoint with: Pharmacokinetic Process
disjoint with: Public Reporting Database
disjoint with: Randomized Tx Assignment
disjoint with: Recombinant Protein System
disjoint with: Treatment Assignment
disjoint with: Xenobiotic Metabolism
disjoint with: in vitro Protein Source
disjoint with: BindingFeature
disjoint with: BioSource
disjoint with: BiochemicalPathwayStep
disjoint with: CellVocabulary
disjoint with: CellularLocationVocabulary
disjoint with: ChemicalStructure
disjoint with: ControlledVocabulary
disjoint with: CovalentBindingFeature
disjoint with: DeltaG
disjoint with: DnaReference
disjoint with: DnaRegionReference
disjoint with: EntityFeature
disjoint with: EntityReference
disjoint with: EntityReferenceTypeVocabulary
disjoint with: Evidence
disjoint with: EvidenceCodeVocabulary
disjoint with: ExperimentalForm
disjoint with: ExperimentalFormVocabulary
disjoint with: FragmentFeature
disjoint with: InteractionVocabulary
disjoint with: KPrime
disjoint with: ModificationFeature
disjoint with: PathwayStep
disjoint with: PhenotypeVocabulary
disjoint with: ProteinReference
disjoint with: Provenance
disjoint with: PublicationXref
disjoint with: RelationshipTypeVocabulary
disjoint with: RelationshipXref
disjoint with: RnaReference
disjoint with: RnaRegionReference
disjoint with: Score
disjoint with: SequenceInterval
disjoint with: SequenceLocation
disjoint with: SequenceModificationVocabulary
disjoint with: SequenceRegionVocabulary
disjoint with: SequenceSite
disjoint with: SmallMoleculeReference
disjoint with: Stoichiometry
disjoint with: TissueVocabulary
disjoint with: UnificationXref
disjoint with: UtilityClass
disjoint with: Xref
comment: NCI C54355 (2006)

Induction
type: Class
subclass of: Modulation
disjoint with: Inhibition
disjoint with: Inhibitor
disjoint with: Journal Peer reviewed
disjoint with: Microsomes
disjoint with: Non randomized Tx Assignment
disjoint with: Observation based DI Report Assessment tool
disjoint with: PK DDI
disjoint with: Public Reporting Database
disjoint with: Randomized Tx Assignment
disjoint with: Recombinant Protein System
disjoint with: Treatment Assignment
disjoint with: in vitro Protein Source
disjoint with: BiochemicalReaction
disjoint with: Catalysis
disjoint with: Complex
disjoint with: ComplexAssembly
disjoint with: Conversion
disjoint with: Degradation
disjoint with: Dna
disjoint with: DnaRegion
disjoint with: Gene
disjoint with: GeneticInteraction
disjoint with: MolecularInteraction
disjoint with: Pathway
disjoint with: PhysicalEntity
disjoint with: Protein
disjoint with: Rna
disjoint with: RnaRegion
disjoint with: SmallMolecule
disjoint with: TemplateReaction
disjoint with: TemplateReactionRegulation
disjoint with: Transport
disjoint with: TransportWithBiochemicalReaction
comment: Definition: A control interaction in which a physical entity improves the ability of an enzyme to catalyze an interaction.

Inhibition
type: Class
subclass of: Modulation
disjoint with: Inhibitor
disjoint with: Journal Peer reviewed
disjoint with: Microsomes
disjoint with: Non randomized Tx Assignment
disjoint with: Observation based DI Report Assessment tool
disjoint with: PK DDI
disjoint with: Public Reporting Database
disjoint with: Randomized Tx Assignment
disjoint with: Recombinant Protein System
disjoint with: Treatment Assignment
disjoint with: in vitro Protein Source
disjoint with: BiochemicalReaction
disjoint with: Catalysis
disjoint with: Complex
disjoint with: ComplexAssembly
disjoint with: Conversion
disjoint with: Degradation
disjoint with: Dna
disjoint with: DnaRegion
disjoint with: Gene
disjoint with: GeneticInteraction
disjoint with: MolecularInteraction
disjoint with: Pathway
disjoint with: PhysicalEntity
disjoint with: Protein
disjoint with: Rna
disjoint with: RnaRegion
disjoint with: SmallMolecule
disjoint with: TemplateReaction
disjoint with: TemplateReactionRegulation
disjoint with: Transport
disjoint with: TransportWithBiochemicalReaction
comment: Definition: A control interaction in which a physical entity reduces the ability of an enzyme to catalyze an interaction.

Journal Peer reviewed
type: Class
disjoint with: Metabolism
disjoint with: Microsomes
disjoint with: Non randomized Tx Assignment
disjoint with: Observation based DI Report Assessment tool
disjoint with: PK DDI
disjoint with: Pharmacodynamic Effect Consequences
disjoint with: Pharmacokinetic Effect Consequences
disjoint with: Pharmacokinetic Process
disjoint with: Public Reporting Database
disjoint with: Randomized Tx Assignment
disjoint with: Recombinant Protein System
disjoint with: Treatment Assignment
disjoint with: Xenobiotic Metabolism
disjoint with: in vitro Protein Source
disjoint with: BindingFeature
disjoint with: BioSource
disjoint with: BiochemicalPathwayStep
disjoint with: BiochemicalReaction
disjoint with: Catalysis
disjoint with: CellVocabulary
disjoint with: CellularLocationVocabulary
disjoint with: ChemicalStructure
disjoint with: Complex
disjoint with: ComplexAssembly
disjoint with: Control
disjoint with: ControlledVocabulary
disjoint with: Conversion
disjoint with: CovalentBindingFeature
disjoint with: Degradation
disjoint with: DeltaG
disjoint with: Dna
disjoint with: DnaReference
disjoint with: DnaRegion
disjoint with: DnaRegionReference
disjoint with: Entity
disjoint with: EntityFeature
disjoint with: EntityReference
disjoint with: EntityReferenceTypeVocabulary
disjoint with: Evidence
disjoint with: EvidenceCodeVocabulary
disjoint with: ExperimentalForm
disjoint with: ExperimentalFormVocabulary
disjoint with: FragmentFeature
disjoint with: Gene
disjoint with: GeneticInteraction
disjoint with: Interaction
disjoint with: InteractionVocabulary
disjoint with: KPrime
disjoint with: ModificationFeature
disjoint with: Modulation
disjoint with: MolecularInteraction
disjoint with: Pathway
disjoint with: PathwayStep
disjoint with: PhenotypeVocabulary
disjoint with: PhysicalEntity
disjoint with: Protein
disjoint with: ProteinReference
disjoint with: Provenance
disjoint with: PublicationXref
disjoint with: RelationshipTypeVocabulary
disjoint with: RelationshipXref
disjoint with: Rna
disjoint with: RnaReference
disjoint with: RnaRegion
disjoint with: RnaRegionReference
disjoint with: Score
disjoint with: SequenceInterval
disjoint with: SequenceLocation
disjoint with: SequenceModificationVocabulary
disjoint with: SequenceRegionVocabulary
disjoint with: SequenceSite
disjoint with: SmallMolecule
disjoint with: SmallMoleculeReference
disjoint with: Stoichiometry
disjoint with: TemplateReaction
disjoint with: TemplateReactionRegulation
disjoint with: TissueVocabulary
disjoint with: Transport
disjoint with: TransportWithBiochemicalReaction

Metabolism
type: Class
disjoint with: Microsomes
disjoint with: Non randomized Tx Assignment
disjoint with: Observation based DI Report Assessment tool
disjoint with: PK DDI
disjoint with: Pharmacodynamic Effect Consequences
disjoint with: Pharmacokinetic Effect Consequences
disjoint with: Public Reporting Database
disjoint with: Randomized Tx Assignment
disjoint with: Recombinant Protein System
disjoint with: Treatment Assignment
disjoint with: in vitro Protein Source
disjoint with: BindingFeature
disjoint with: BioSource
disjoint with: BiochemicalPathwayStep
disjoint with: CellVocabulary
disjoint with: CellularLocationVocabulary
disjoint with: ChemicalStructure
disjoint with: ControlledVocabulary
disjoint with: CovalentBindingFeature
disjoint with: DeltaG
disjoint with: DnaReference
disjoint with: DnaRegionReference
disjoint with: EntityFeature
disjoint with: EntityReference
disjoint with: EntityReferenceTypeVocabulary
disjoint with: Evidence
disjoint with: EvidenceCodeVocabulary
disjoint with: ExperimentalForm
disjoint with: ExperimentalFormVocabulary
disjoint with: FragmentFeature
disjoint with: InteractionVocabulary
disjoint with: KPrime
disjoint with: ModificationFeature
disjoint with: PathwayStep
disjoint with: PhenotypeVocabulary
disjoint with: ProteinReference
disjoint with: Provenance
disjoint with: PublicationXref
disjoint with: RelationshipTypeVocabulary
disjoint with: RelationshipXref
disjoint with: RnaReference
disjoint with: RnaRegionReference
disjoint with: Score
disjoint with: SequenceInterval
disjoint with: SequenceLocation
disjoint with: SequenceModificationVocabulary
disjoint with: SequenceRegionVocabulary
disjoint with: SequenceSite
disjoint with: SmallMoleculeReference
disjoint with: Stoichiometry
disjoint with: TissueVocabulary
disjoint with: UnificationXref
disjoint with: UtilityClass
disjoint with: Xref
comment: "Processes that cause many of the chemical changes in living organisms, including anabolism and catabolism. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation." GO:0008152 'metabolism'

Microsomes
type: Class
subclass of: in vitro Protein Source
disjoint with: Non randomized Tx Assignment
disjoint with: Observation based DI Report Assessment tool
disjoint with: PK DDI
disjoint with: Pharmacodynamic Effect Consequences
disjoint with: Pharmacokinetic Effect Consequences
disjoint with: Pharmacokinetic Process
disjoint with: Public Reporting Database
disjoint with: Randomized Tx Assignment
disjoint with: Recombinant Protein System
disjoint with: Treatment Assignment
disjoint with: Xenobiotic Metabolism
disjoint with: BindingFeature
disjoint with: BioSource
disjoint with: BiochemicalPathwayStep
disjoint with: BiochemicalReaction
disjoint with: Catalysis
disjoint with: CellVocabulary
disjoint with: CellularLocationVocabulary
disjoint with: ChemicalStructure
disjoint with: Complex
disjoint with: ComplexAssembly
disjoint with: Control
disjoint with: ControlledVocabulary
disjoint with: Conversion
disjoint with: CovalentBindingFeature
disjoint with: Degradation
disjoint with: DeltaG
disjoint with: Dna
disjoint with: DnaReference
disjoint with: DnaRegion
disjoint with: DnaRegionReference
disjoint with: Entity
disjoint with: EntityFeature
disjoint with: EntityReference
disjoint with: EntityReferenceTypeVocabulary
disjoint with: Evidence
disjoint with: EvidenceCodeVocabulary
disjoint with: ExperimentalForm
disjoint with: ExperimentalFormVocabulary
disjoint with: FragmentFeature
disjoint with: Gene
disjoint with: GeneticInteraction
disjoint with: Interaction
disjoint with: InteractionVocabulary
disjoint with: KPrime
disjoint with: ModificationFeature
disjoint with: Modulation
disjoint with: MolecularInteraction
disjoint with: Pathway
disjoint with: PathwayStep
disjoint with: PhenotypeVocabulary
disjoint with: PhysicalEntity
disjoint with: Protein
disjoint with: ProteinReference
disjoint with: Provenance
disjoint with: PublicationXref
disjoint with: RelationshipTypeVocabulary
disjoint with: RelationshipXref
disjoint with: Rna
disjoint with: RnaReference
disjoint with: RnaRegion
disjoint with: RnaRegionReference
disjoint with: Score
disjoint with: SequenceInterval
disjoint with: SequenceLocation
disjoint with: SequenceModificationVocabulary
disjoint with: SequenceRegionVocabulary
disjoint with: SequenceSite
disjoint with: SmallMolecule
disjoint with: SmallMoleculeReference
disjoint with: Stoichiometry
disjoint with: TemplateReaction
disjoint with: TemplateReactionRegulation
disjoint with: TissueVocabulary
disjoint with: Transport
disjoint with: TransportWithBiochemicalReaction
disjoint with: UnificationXref
disjoint with: UtilityClass

Non randomized Tx Assignment
type: Class
subclass of: Treatment Assignment
disjoint with: Observation based DI Report Assessment tool
disjoint with: PK DDI
disjoint with: Pharmacodynamic Effect Consequences
disjoint with: Pharmacokinetic Effect Consequences
disjoint with: Pharmacokinetic Process
disjoint with: Public Reporting Database
disjoint with: Randomized Tx Assignment
disjoint with: Recombinant Protein System
disjoint with: Xenobiotic Metabolism
disjoint with: in vitro Protein Source
disjoint with: BindingFeature
disjoint with: BioSource
disjoint with: BiochemicalPathwayStep
disjoint with: BiochemicalReaction
disjoint with: Catalysis
disjoint with: CellVocabulary
disjoint with: CellularLocationVocabulary
disjoint with: ChemicalStructure
disjoint with: Complex
disjoint with: ComplexAssembly
disjoint with: Control
disjoint with: ControlledVocabulary
disjoint with: Conversion
disjoint with: CovalentBindingFeature
disjoint with: Degradation
disjoint with: DeltaG
disjoint with: Dna
disjoint with: DnaReference
disjoint with: DnaRegion
disjoint with: DnaRegionReference
disjoint with: Entity
disjoint with: EntityFeature
disjoint with: EntityReference
disjoint with: EntityReferenceTypeVocabulary
disjoint with: Evidence
disjoint with: EvidenceCodeVocabulary
disjoint with: ExperimentalForm
disjoint with: ExperimentalFormVocabulary
disjoint with: FragmentFeature
disjoint with: Gene
disjoint with: GeneticInteraction
disjoint with: Interaction
disjoint with: InteractionVocabulary
disjoint with: KPrime
disjoint with: ModificationFeature
disjoint with: Modulation
disjoint with: MolecularInteraction
disjoint with: Pathway
disjoint with: PathwayStep
disjoint with: PhenotypeVocabulary
disjoint with: PhysicalEntity
disjoint with: Protein
disjoint with: ProteinReference
disjoint with: Provenance
disjoint with: PublicationXref
disjoint with: RelationshipTypeVocabulary
disjoint with: RelationshipXref
disjoint with: Rna
disjoint with: RnaReference
disjoint with: RnaRegion
disjoint with: RnaRegionReference
disjoint with: Score
disjoint with: SequenceInterval
disjoint with: SequenceLocation
disjoint with: SequenceModificationVocabulary
disjoint with: SequenceRegionVocabulary
disjoint with: SequenceSite
disjoint with: SmallMolecule
disjoint with: SmallMoleculeReference
disjoint with: Stoichiometry
disjoint with: TemplateReaction
disjoint with: TemplateReactionRegulation
disjoint with: TissueVocabulary
disjoint with: Transport
disjoint with: TransportWithBiochemicalReaction
disjoint with: UnificationXref
disjoint with: UtilityClass
disjoint with: Xref

Observation based DI Report Assessment tool
type: Class
disjoint with: PK DDI
disjoint with: Pharmacodynamic Effect Consequences
disjoint with: Pharmacokinetic Effect Consequences
disjoint with: Pharmacokinetic Process
disjoint with: Public Reporting Database
disjoint with: Randomized Tx Assignment
disjoint with: Recombinant Protein System
disjoint with: Treatment Assignment
disjoint with: Xenobiotic Metabolism
disjoint with: in vitro Protein Source
disjoint with: BindingFeature
disjoint with: BioSource
disjoint with: BiochemicalPathwayStep
disjoint with: BiochemicalReaction
disjoint with: Catalysis
disjoint with: CellVocabulary
disjoint with: CellularLocationVocabulary
disjoint with: ChemicalStructure
disjoint with: Complex
disjoint with: ComplexAssembly
disjoint with: Control
disjoint with: ControlledVocabulary
disjoint with: Conversion
disjoint with: CovalentBindingFeature
disjoint with: Degradation
disjoint with: DeltaG
disjoint with: Dna
disjoint with: DnaReference
disjoint with: DnaRegion
disjoint with: DnaRegionReference
disjoint with: Entity
disjoint with: EntityFeature
disjoint with: EntityReference
disjoint with: EntityReferenceTypeVocabulary
disjoint with: Evidence
disjoint with: EvidenceCodeVocabulary
disjoint with: ExperimentalForm
disjoint with: ExperimentalFormVocabulary
disjoint with: FragmentFeature
disjoint with: Gene
disjoint with: GeneticInteraction
disjoint with: Interaction
disjoint with: InteractionVocabulary
disjoint with: KPrime
disjoint with: ModificationFeature
disjoint with: Modulation
disjoint with: MolecularInteraction
disjoint with: Pathway
disjoint with: PathwayStep
disjoint with: PhenotypeVocabulary
disjoint with: PhysicalEntity
disjoint with: Protein
disjoint with: ProteinReference
disjoint with: Provenance
disjoint with: PublicationXref
disjoint with: RelationshipTypeVocabulary
disjoint with: RelationshipXref
disjoint with: Rna
disjoint with: RnaReference
disjoint with: RnaRegion
disjoint with: RnaRegionReference
disjoint with: Score
disjoint with: SequenceInterval
disjoint with: SequenceLocation
disjoint with: SequenceModificationVocabulary
disjoint with: SequenceRegionVocabulary
disjoint with: SequenceSite
disjoint with: SmallMolecule
disjoint with: SmallMoleculeReference
disjoint with: Stoichiometry
disjoint with: TemplateReaction
disjoint with: TemplateReactionRegulation
disjoint with: TissueVocabulary
disjoint with: Transport
disjoint with: TransportWithBiochemicalReaction
disjoint with: UnificationXref
disjoint with: UtilityClass
disjoint with: Xref
comment: An assessment tool for grading the validity of an observation-based report's claims

PK DDI
type: Class
subclass of: Drug Drug Interaction
disjoint with: Pharmacodynamic Effect Consequences
disjoint with: Pharmacokinetic Effect Consequences
disjoint with: Pharmacokinetic Process
disjoint with: Public Reporting Database
disjoint with: Randomized Tx Assignment
disjoint with: Recombinant Protein System
disjoint with: Treatment Assignment
disjoint with: Xenobiotic Metabolism
disjoint with: in vitro Protein Source
disjoint with: BindingFeature
disjoint with: BioSource
disjoint with: BiochemicalPathwayStep
disjoint with: BiochemicalReaction
disjoint with: Catalysis
disjoint with: CellVocabulary
disjoint with: CellularLocationVocabulary
disjoint with: ChemicalStructure
disjoint with: Complex
disjoint with: ComplexAssembly
disjoint with: Control
disjoint with: ControlledVocabulary
disjoint with: Conversion
disjoint with: CovalentBindingFeature
disjoint with: Degradation
disjoint with: DeltaG
disjoint with: Dna
disjoint with: DnaReference
disjoint with: DnaRegion
disjoint with: DnaRegionReference
disjoint with: Entity
disjoint with: EntityFeature
disjoint with: EntityReference
disjoint with: EntityReferenceTypeVocabulary
disjoint with: Evidence
disjoint with: EvidenceCodeVocabulary
disjoint with: ExperimentalForm
disjoint with: ExperimentalFormVocabulary
disjoint with: FragmentFeature
disjoint with: Gene
disjoint with: GeneticInteraction
disjoint with: Interaction
disjoint with: InteractionVocabulary
disjoint with: KPrime
disjoint with: ModificationFeature
disjoint with: Modulation
disjoint with: MolecularInteraction
disjoint with: Pathway
disjoint with: PathwayStep
disjoint with: PhenotypeVocabulary
disjoint with: PhysicalEntity
disjoint with: Protein
disjoint with: ProteinReference
disjoint with: Provenance
disjoint with: PublicationXref
disjoint with: RelationshipTypeVocabulary
disjoint with: RelationshipXref
disjoint with: Rna
disjoint with: RnaReference
disjoint with: RnaRegion
disjoint with: RnaRegionReference
disjoint with: Score
disjoint with: SequenceInterval
disjoint with: SequenceLocation
disjoint with: SequenceModificationVocabulary
disjoint with: SequenceRegionVocabulary
disjoint with: SequenceSite
disjoint with: SmallMolecule
disjoint with: SmallMoleculeReference
disjoint with: Stoichiometry
disjoint with: TemplateReaction
disjoint with: TemplateReactionRegulation
disjoint with: TissueVocabulary
disjoint with: Transport
disjoint with: TransportWithBiochemicalReaction
disjoint with: UnificationXref
disjoint with: UtilityClass
disjoint with: Xref
comment: A DDI that occurs via a pharmacokinetic mechanism

Pharmacodynamic Effect Consequences
type: Class
disjoint with: Pharmacokinetic Effect Consequences
disjoint with: Pharmacokinetic Process
disjoint with: Public Reporting Database
disjoint with: Randomized Tx Assignment
disjoint with: Recombinant Protein System
disjoint with: Treatment Assignment
disjoint with: Xenobiotic Metabolism
disjoint with: in vitro Protein Source
disjoint with: BindingFeature
disjoint with: BioSource
disjoint with: BiochemicalPathwayStep
disjoint with: CellVocabulary
disjoint with: CellularLocationVocabulary
disjoint with: ChemicalStructure
disjoint with: ControlledVocabulary
disjoint with: CovalentBindingFeature
disjoint with: DeltaG
disjoint with: DnaReference
disjoint with: DnaRegionReference
disjoint with: EntityFeature
disjoint with: EntityReference
disjoint with: EntityReferenceTypeVocabulary
disjoint with: Evidence
disjoint with: EvidenceCodeVocabulary
disjoint with: ExperimentalForm
disjoint with: ExperimentalFormVocabulary
disjoint with: FragmentFeature
disjoint with: InteractionVocabulary
disjoint with: KPrime
disjoint with: ModificationFeature
disjoint with: PathwayStep
disjoint with: PhenotypeVocabulary
disjoint with: ProteinReference
disjoint with: Provenance
disjoint with: PublicationXref
disjoint with: RelationshipTypeVocabulary
disjoint with: RelationshipXref
disjoint with: RnaReference
disjoint with: RnaRegionReference
disjoint with: Score
disjoint with: SequenceInterval
disjoint with: SequenceLocation
disjoint with: SequenceModificationVocabulary
disjoint with: SequenceRegionVocabulary
disjoint with: SequenceSite
disjoint with: SmallMoleculeReference
disjoint with: Stoichiometry
disjoint with: TissueVocabulary
disjoint with: UnificationXref
disjoint with: UtilityClass
disjoint with: Xref
comment: The consequences resulted from pharmacodynamic interactions between the drug and another drug or food.

Pharmacokinetic Effect Consequences
type: Class
disjoint with: Pharmacokinetic Process
disjoint with: Public Reporting Database
disjoint with: Randomized Tx Assignment
disjoint with: Recombinant Protein System
disjoint with: Treatment Assignment
disjoint with: Xenobiotic Metabolism
disjoint with: in vitro Protein Source
disjoint with: BindingFeature
disjoint with: BioSource
disjoint with: BiochemicalPathwayStep
disjoint with: CellVocabulary
disjoint with: CellularLocationVocabulary
disjoint with: ChemicalStructure
disjoint with: ControlledVocabulary
disjoint with: CovalentBindingFeature
disjoint with: DeltaG
disjoint with: DnaReference
disjoint with: DnaRegionReference
disjoint with: EntityFeature
disjoint with: EntityReference
disjoint with: EntityReferenceTypeVocabulary
disjoint with: Evidence
disjoint with: EvidenceCodeVocabulary
disjoint with: ExperimentalForm
disjoint with: ExperimentalFormVocabulary
disjoint with: FragmentFeature
disjoint with: InteractionVocabulary
disjoint with: KPrime
disjoint with: ModificationFeature
disjoint with: PathwayStep
disjoint with: PhenotypeVocabulary
disjoint with: ProteinReference
disjoint with: Provenance
disjoint with: PublicationXref
disjoint with: RelationshipTypeVocabulary
disjoint with: RelationshipXref
disjoint with: RnaReference
disjoint with: RnaRegionReference
disjoint with: Score
disjoint with: SequenceInterval
disjoint with: SequenceLocation
disjoint with: SequenceModificationVocabulary
disjoint with: SequenceRegionVocabulary
disjoint with: SequenceSite
disjoint with: SmallMoleculeReference
disjoint with: Stoichiometry
disjoint with: TissueVocabulary
disjoint with: UnificationXref
disjoint with: UtilityClass
disjoint with: Xref
comment: The consequences resulted from pharmacokinetic interactions between the drug and another drug or food. NCI C54354 (2006)

Pharmacokinetic Process
type: Class
disjoint with: Public Reporting Database
disjoint with: Randomized Tx Assignment
disjoint with: Recombinant Protein System
disjoint with: Treatment Assignment
disjoint with: in vitro Protein Source
disjoint with: BindingFeature
disjoint with: BioSource
disjoint with: BiochemicalPathwayStep
disjoint with: CellVocabulary
disjoint with: CellularLocationVocabulary
disjoint with: ChemicalStructure
disjoint with: ControlledVocabulary
disjoint with: CovalentBindingFeature
disjoint with: DeltaG
disjoint with: DnaReference
disjoint with: DnaRegionReference
disjoint with: EntityFeature
disjoint with: EntityReference
disjoint with: EntityReferenceTypeVocabulary
disjoint with: Evidence
disjoint with: EvidenceCodeVocabulary
disjoint with: ExperimentalForm
disjoint with: ExperimentalFormVocabulary
disjoint with: FragmentFeature
disjoint with: InteractionVocabulary
disjoint with: KPrime
disjoint with: ModificationFeature
disjoint with: PathwayStep
disjoint with: PhenotypeVocabulary
disjoint with: ProteinReference
disjoint with: Provenance
disjoint with: PublicationXref
disjoint with: RelationshipTypeVocabulary
disjoint with: RelationshipXref
disjoint with: RnaReference
disjoint with: RnaRegionReference
disjoint with: Score
disjoint with: SequenceInterval
disjoint with: SequenceLocation
disjoint with: SequenceModificationVocabulary
disjoint with: SequenceRegionVocabulary
disjoint with: SequenceSite
disjoint with: SmallMoleculeReference
disjoint with: Stoichiometry
disjoint with: TissueVocabulary
disjoint with: UnificationXref
disjoint with: UtilityClass
disjoint with: Xref
comment: A physiological process that moves molecular entities (e.g. drugs) within biological systems -- absorption, distribution, binding, elimination, biotransformation, and excretion

Public Reporting Database
type: Class
disjoint with: Randomized Tx Assignment
disjoint with: Recombinant Protein System
disjoint with: Treatment Assignment
disjoint with: Xenobiotic Metabolism
disjoint with: in vitro Protein Source
disjoint with: BindingFeature
disjoint with: BioSource
disjoint with: BiochemicalPathwayStep
disjoint with: BiochemicalReaction
disjoint with: Catalysis
disjoint with: CellVocabulary
disjoint with: CellularLocationVocabulary
disjoint with: ChemicalStructure
disjoint with: Complex
disjoint with: ComplexAssembly
disjoint with: Control
disjoint with: ControlledVocabulary
disjoint with: Conversion
disjoint with: CovalentBindingFeature
disjoint with: Degradation
disjoint with: DeltaG
disjoint with: Dna
disjoint with: DnaReference
disjoint with: DnaRegion
disjoint with: DnaRegionReference
disjoint with: Entity
disjoint with: EntityFeature
disjoint with: EntityReference
disjoint with: EntityReferenceTypeVocabulary
disjoint with: Evidence
disjoint with: EvidenceCodeVocabulary
disjoint with: ExperimentalForm
disjoint with: ExperimentalFormVocabulary
disjoint with: FragmentFeature
disjoint with: Gene
disjoint with: GeneticInteraction
disjoint with: Interaction
disjoint with: InteractionVocabulary
disjoint with: KPrime
disjoint with: ModificationFeature
disjoint with: Modulation
disjoint with: MolecularInteraction
disjoint with: Pathway
disjoint with: PathwayStep
disjoint with: PhenotypeVocabulary
disjoint with: PhysicalEntity
disjoint with: Protein
disjoint with: ProteinReference
disjoint with: Provenance
disjoint with: PublicationXref
disjoint with: RelationshipTypeVocabulary
disjoint with: RelationshipXref
disjoint with: Rna
disjoint with: RnaReference
disjoint with: RnaRegion
disjoint with: RnaRegionReference
disjoint with: Score
disjoint with: SequenceInterval
disjoint with: SequenceLocation
disjoint with: SequenceModificationVocabulary
disjoint with: SequenceRegionVocabulary
disjoint with: SequenceSite
disjoint with: SmallMolecule
disjoint with: SmallMoleculeReference
disjoint with: Stoichiometry
disjoint with: TemplateReaction
disjoint with: TemplateReactionRegulation
disjoint with: TissueVocabulary
disjoint with: Transport
disjoint with: TransportWithBiochemicalReaction
disjoint with: UnificationXref
disjoint with: UtilityClass
disjoint with: Xref
comment: A database that receives and stores reports of events of public health interest from various persons and makes these reports accessible to the general public

Randomized Tx Assignment
type: Class
subclass of: Treatment Assignment
disjoint with: Recombinant Protein System
disjoint with: Xenobiotic Metabolism
disjoint with: in vitro Protein Source
disjoint with: BindingFeature
disjoint with: BioSource
disjoint with: BiochemicalPathwayStep
disjoint with: BiochemicalReaction
disjoint with: Catalysis
disjoint with: CellVocabulary
disjoint with: CellularLocationVocabulary
disjoint with: ChemicalStructure
disjoint with: Complex
disjoint with: ComplexAssembly
disjoint with: Control
disjoint with: ControlledVocabulary
disjoint with: Conversion
disjoint with: CovalentBindingFeature
disjoint with: Degradation
disjoint with: DeltaG
disjoint with: Dna
disjoint with: DnaReference
disjoint with: DnaRegion
disjoint with: DnaRegionReference
disjoint with: Entity
disjoint with: EntityFeature
disjoint with: EntityReference
disjoint with: EntityReferenceTypeVocabulary
disjoint with: Evidence
disjoint with: EvidenceCodeVocabulary
disjoint with: ExperimentalForm
disjoint with: ExperimentalFormVocabulary
disjoint with: FragmentFeature
disjoint with: Gene
disjoint with: GeneticInteraction
disjoint with: Interaction
disjoint with: InteractionVocabulary
disjoint with: KPrime
disjoint with: ModificationFeature
disjoint with: Modulation
disjoint with: MolecularInteraction
disjoint with: Pathway
disjoint with: PathwayStep
disjoint with: PhenotypeVocabulary
disjoint with: PhysicalEntity
disjoint with: Protein
disjoint with: ProteinReference
disjoint with: Provenance
disjoint with: PublicationXref
disjoint with: RelationshipTypeVocabulary
disjoint with: RelationshipXref
disjoint with: Rna
disjoint with: RnaReference
disjoint with: RnaRegion
disjoint with: RnaRegionReference
disjoint with: Score
disjoint with: SequenceInterval
disjoint with: SequenceLocation
disjoint with: SequenceModificationVocabulary
disjoint with: SequenceRegionVocabulary
disjoint with: SequenceSite
disjoint with: SmallMolecule
disjoint with: SmallMoleculeReference
disjoint with: Stoichiometry
disjoint with: TemplateReaction
disjoint with: TemplateReactionRegulation
disjoint with: TissueVocabulary
disjoint with: Transport
disjoint with: TransportWithBiochemicalReaction
disjoint with: UnificationXref
disjoint with: UtilityClass
disjoint with: Xref
comment: A randomized treatment assignment method

Recombinant Protein System
type: Class
subclass of: in vitro Protein Source
disjoint with: Treatment Assignment
disjoint with: Xenobiotic Metabolism
disjoint with: BindingFeature
disjoint with: BioSource
disjoint with: BiochemicalPathwayStep
disjoint with: BiochemicalReaction
disjoint with: Catalysis
disjoint with: CellVocabulary
disjoint with: CellularLocationVocabulary
disjoint with: ChemicalStructure
disjoint with: Complex
disjoint with: ComplexAssembly
disjoint with: Control
disjoint with: ControlledVocabulary
disjoint with: Conversion
disjoint with: CovalentBindingFeature
disjoint with: Degradation
disjoint with: DeltaG
disjoint with: Dna
disjoint with: DnaReference
disjoint with: DnaRegion
disjoint with: DnaRegionReference
disjoint with: Entity
disjoint with: EntityFeature
disjoint with: EntityReference
disjoint with: EntityReferenceTypeVocabulary
disjoint with: Evidence
disjoint with: EvidenceCodeVocabulary
disjoint with: ExperimentalForm
disjoint with: ExperimentalFormVocabulary
disjoint with: FragmentFeature
disjoint with: Gene
disjoint with: GeneticInteraction
disjoint with: Interaction
disjoint with: InteractionVocabulary
disjoint with: KPrime
disjoint with: ModificationFeature
disjoint with: Modulation
disjoint with: MolecularInteraction
disjoint with: Pathway
disjoint with: PathwayStep
disjoint with: PhenotypeVocabulary
disjoint with: PhysicalEntity
disjoint with: Protein
disjoint with: ProteinReference
disjoint with: Provenance
disjoint with: PublicationXref
disjoint with: RelationshipTypeVocabulary
disjoint with: RelationshipXref
disjoint with: Rna
disjoint with: RnaReference
disjoint with: RnaRegion
disjoint with: RnaRegionReference
disjoint with: Score
disjoint with: SequenceInterval
disjoint with: SequenceLocation
disjoint with: SequenceModificationVocabulary
disjoint with: SequenceRegionVocabulary
disjoint with: SequenceSite
disjoint with: SmallMolecule
disjoint with: SmallMoleculeReference
disjoint with: Stoichiometry
disjoint with: TemplateReaction
disjoint with: TemplateReactionRegulation
disjoint with: TissueVocabulary
disjoint with: Transport
disjoint with: TransportWithBiochemicalReaction
disjoint with: UnificationXref
disjoint with: UtilityClass
disjoint with: Xref
comment: A system of proteins "produced by genes or recombinant DNA that has been artificially engineered and inserted into a heterologous host. Recombinant proteins are used extensively by investigators of disease pathways to identify proteintargets for potential drug therapies." Adapted from NCI C17081 'Recombinant_Protein'

Treatment Assignment
type: Class
disjoint with: Xenobiotic Metabolism
disjoint with: in vitro Protein Source
disjoint with: BindingFeature
disjoint with: BioSource
disjoint with: BiochemicalPathwayStep
disjoint with: BiochemicalReaction
disjoint with: Catalysis
disjoint with: CellVocabulary
disjoint with: CellularLocationVocabulary
disjoint with: ChemicalStructure
disjoint with: Complex
disjoint with: ComplexAssembly
disjoint with: Control
disjoint with: ControlledVocabulary
disjoint with: Conversion
disjoint with: CovalentBindingFeature
disjoint with: Degradation
disjoint with: DeltaG
disjoint with: Dna
disjoint with: DnaReference
disjoint with: DnaRegion
disjoint with: DnaRegionReference
disjoint with: Entity
disjoint with: EntityFeature
disjoint with: EntityReference
disjoint with: EntityReferenceTypeVocabulary
disjoint with: Evidence
disjoint with: EvidenceCodeVocabulary
disjoint with: ExperimentalForm
disjoint with: ExperimentalFormVocabulary
disjoint with: FragmentFeature
disjoint with: Gene
disjoint with: GeneticInteraction
disjoint with: Interaction
disjoint with: InteractionVocabulary
disjoint with: KPrime
disjoint with: ModificationFeature
disjoint with: Modulation
disjoint with: MolecularInteraction
disjoint with: Pathway
disjoint with: PathwayStep
disjoint with: PhenotypeVocabulary
disjoint with: PhysicalEntity
disjoint with: Protein
disjoint with: ProteinReference
disjoint with: Provenance
disjoint with: PublicationXref
disjoint with: RelationshipTypeVocabulary
disjoint with: RelationshipXref
disjoint with: Rna
disjoint with: RnaReference
disjoint with: RnaRegion
disjoint with: RnaRegionReference
disjoint with: Score
disjoint with: SequenceInterval
disjoint with: SequenceLocation
disjoint with: SequenceModificationVocabulary
disjoint with: SequenceRegionVocabulary
disjoint with: SequenceSite
disjoint with: SmallMolecule
disjoint with: SmallMoleculeReference
disjoint with: Stoichiometry
disjoint with: TemplateReaction
disjoint with: TemplateReactionRegulation
disjoint with: TissueVocabulary
disjoint with: Transport
disjoint with: TransportWithBiochemicalReaction
disjoint with: UnificationXref
disjoint with: UtilityClass
disjoint with: Xref
comment: Method for assigning clinical trial participants to treatment and control groups

Xenobiotic Metabolism
type: Class
subclass of: Cellular Metabolism
disjoint with: in vitro Protein Source
disjoint with: BindingFeature
disjoint with: BioSource
disjoint with: BiochemicalPathwayStep
disjoint with: CellVocabulary
disjoint with: CellularLocationVocabulary
disjoint with: ChemicalStructure
disjoint with: ControlledVocabulary
disjoint with: CovalentBindingFeature
disjoint with: DeltaG
disjoint with: DnaReference
disjoint with: DnaRegionReference
disjoint with: EntityFeature
disjoint with: EntityReference
disjoint with: EntityReferenceTypeVocabulary
disjoint with: Evidence
disjoint with: EvidenceCodeVocabulary
disjoint with: ExperimentalForm
disjoint with: ExperimentalFormVocabulary
disjoint with: FragmentFeature
disjoint with: InteractionVocabulary
disjoint with: KPrime
disjoint with: ModificationFeature
disjoint with: PathwayStep
disjoint with: PhenotypeVocabulary
disjoint with: ProteinReference
disjoint with: Provenance
disjoint with: PublicationXref
disjoint with: RelationshipTypeVocabulary
disjoint with: RelationshipXref
disjoint with: RnaReference
disjoint with: RnaRegionReference
disjoint with: Score
disjoint with: SequenceInterval
disjoint with: SequenceLocation
disjoint with: SequenceModificationVocabulary
disjoint with: SequenceRegionVocabulary
disjoint with: SequenceSite
disjoint with: SmallMoleculeReference
disjoint with: Stoichiometry
disjoint with: TissueVocabulary
disjoint with: UnificationXref
disjoint with: UtilityClass
disjoint with: Xref
comment: "The chemical reactions and pathways involving a xenobiotic compound, a compound foreign to living organisms. Used of chemical compounds, e.g. a xenobiotic chemical, such as a pesticide." GO:0006805

in vitro Protein Source
type: Class
disjoint with: BindingFeature
disjoint with: BioSource
disjoint with: BiochemicalPathwayStep
disjoint with: BiochemicalReaction
disjoint with: Catalysis
disjoint with: CellVocabulary
disjoint with: CellularLocationVocabulary
disjoint with: ChemicalStructure
disjoint with: Complex
disjoint with: ComplexAssembly
disjoint with: Control
disjoint with: ControlledVocabulary
disjoint with: Conversion
disjoint with: CovalentBindingFeature
disjoint with: Degradation
disjoint with: DeltaG
disjoint with: Dna
disjoint with: DnaReference
disjoint with: DnaRegion
disjoint with: DnaRegionReference
disjoint with: Entity
disjoint with: EntityFeature
disjoint with: EntityReference
disjoint with: EntityReferenceTypeVocabulary
disjoint with: Evidence
disjoint with: EvidenceCodeVocabulary
disjoint with: ExperimentalForm
disjoint with: ExperimentalFormVocabulary
disjoint with: FragmentFeature
disjoint with: Gene
disjoint with: GeneticInteraction
disjoint with: Interaction
disjoint with: InteractionVocabulary
disjoint with: KPrime
disjoint with: ModificationFeature
disjoint with: Modulation
disjoint with: MolecularInteraction
disjoint with: Pathway
disjoint with: PathwayStep
disjoint with: PhenotypeVocabulary
disjoint with: PhysicalEntity
disjoint with: Protein
disjoint with: ProteinReference
disjoint with: Provenance
disjoint with: PublicationXref
disjoint with: RelationshipTypeVocabulary
disjoint with: RelationshipXref
disjoint with: Rna
disjoint with: RnaReference
disjoint with: RnaRegion
disjoint with: RnaRegionReference
disjoint with: Score
disjoint with: SequenceInterval
disjoint with: SequenceLocation
disjoint with: SequenceModificationVocabulary
disjoint with: SequenceRegionVocabulary
disjoint with: SequenceSite
disjoint with: SmallMolecule
disjoint with: SmallMoleculeReference
disjoint with: Stoichiometry
disjoint with: TemplateReaction
disjoint with: TemplateReactionRegulation
disjoint with: TissueVocabulary
disjoint with: Transport
disjoint with: TransportWithBiochemicalReaction
disjoint with: UnificationXref
disjoint with: UtilityClass
disjoint with: Xref
comment: A source of proteins that are used in biological experimentation

BindingFeature
type: Class
subclass of: EntityFeature
disjoint with: BioSource
disjoint with: BiochemicalPathwayStep
disjoint with: CellVocabulary
disjoint with: CellularLocationVocabulary
disjoint with: ChemicalStructure
disjoint with: ControlledVocabulary
disjoint with: DeltaG
disjoint with: DnaReference
disjoint with: DnaRegionReference
disjoint with: EntityReference
disjoint with: EntityReferenceTypeVocabulary
disjoint with: Evidence
disjoint with: EvidenceCodeVocabulary
disjoint with: ExperimentalForm
disjoint with: ExperimentalFormVocabulary
disjoint with: FragmentFeature
disjoint with: InteractionVocabulary
disjoint with: KPrime
disjoint with: PathwayStep
disjoint with: PhenotypeVocabulary
disjoint with: ProteinReference
disjoint with: Provenance
disjoint with: PublicationXref
disjoint with: RelationshipTypeVocabulary
disjoint with: RelationshipXref
disjoint with: RnaReference
disjoint with: RnaRegionReference
disjoint with: Score
disjoint with: SequenceInterval
disjoint with: SequenceLocation
disjoint with: SequenceModificationVocabulary
disjoint with: SequenceRegionVocabulary
disjoint with: SequenceSite
disjoint with: SmallMoleculeReference
disjoint with: Stoichiometry
disjoint with: TissueVocabulary
disjoint with: UnificationXref
disjoint with: Xref
comment: Definition : An entity feature that represent the bound state of a physical entity. A pair of binding features represents a bond. Rationale: A physical entity in a molecular complex is considered as a new state of an entity as it is structurally and functionally different. Binding features provide facilities for describing these states. Similar to other features, a molecule can have bound and not-bound states. Usage: Typically, binding features are present in pairs, each describing the binding characteristic for one of the interacting physical entities. One exception is using a binding feature with no paired feature to describe any potential binding. For example, an unbound receptor can be described by using a "not-feature" property with an unpaired binding feature as its value. BindingSiteType and featureLocation allows annotating the binding location. IntraMolecular property should be set to "true" if the bond links two parts of the same molecule. A pair of binding features are still used where they are owned by the same physical entity. If the binding is due to the covalent interactions, for example in the case of lipoproteins, CovalentBindingFeature subclass should be used instead of this class.

BioSource
type: Class
subclass of: UtilityClass
disjoint with: BiochemicalPathwayStep
disjoint with: CellVocabulary
disjoint with: CellularLocationVocabulary
disjoint with: ChemicalStructure
disjoint with: ControlledVocabulary
disjoint with: CovalentBindingFeature
disjoint with: DeltaG
disjoint with: DnaReference
disjoint with: DnaRegionReference
disjoint with: EntityFeature
disjoint with: EntityReference
disjoint with: EntityReferenceTypeVocabulary
disjoint with: Evidence
disjoint with: EvidenceCodeVocabulary
disjoint with: ExperimentalForm
disjoint with: ExperimentalFormVocabulary
disjoint with: FragmentFeature
disjoint with: InteractionVocabulary
disjoint with: KPrime
disjoint with: ModificationFeature
disjoint with: PathwayStep
disjoint with: PhenotypeVocabulary
disjoint with: ProteinReference
disjoint with: Provenance
disjoint with: PublicationXref
disjoint with: RelationshipTypeVocabulary
disjoint with: RelationshipXref
disjoint with: RnaReference
disjoint with: RnaRegionReference
disjoint with: Score
disjoint with: SequenceInterval
disjoint with: SequenceLocation
disjoint with: SequenceModificationVocabulary
disjoint with: SequenceRegionVocabulary
disjoint with: SequenceSite
disjoint with: SmallMoleculeReference
disjoint with: Stoichiometry
disjoint with: TissueVocabulary
disjoint with: UnificationXref
disjoint with: Xref
comment: Definition: The biological source (organism, tissue or cell type) of an Entity. Usage: Some entities are considered source-neutral (e.g. small molecules), and the biological source of others can be deduced from their constituentss (e.g. complex, pathway). Instances: HeLa cells, Homo sapiens, and mouse liver tissue.

BiochemicalPathwayStep
type: Class
subclass of: PathwayStep
subclass of: Restriction
  on property: stepProcess
  all values from: Control
disjoint with: CellVocabulary
disjoint with: CellularLocationVocabulary
disjoint with: ChemicalStructure
disjoint with: ControlledVocabulary
disjoint with: CovalentBindingFeature
disjoint with: DeltaG
disjoint with: DnaReference
disjoint with: DnaRegionReference
disjoint with: EntityFeature
disjoint with: EntityReference
disjoint with: EntityReferenceTypeVocabulary
disjoint with: Evidence
disjoint with: EvidenceCodeVocabulary
disjoint with: ExperimentalForm
disjoint with: ExperimentalFormVocabulary
disjoint with: FragmentFeature
disjoint with: InteractionVocabulary
disjoint with: KPrime
disjoint with: ModificationFeature
disjoint with: PhenotypeVocabulary
disjoint with: ProteinReference
disjoint with: Provenance
disjoint with: PublicationXref
disjoint with: RelationshipTypeVocabulary
disjoint with: RelationshipXref
disjoint with: RnaReference
disjoint with: RnaRegionReference
disjoint with: Score
disjoint with: SequenceInterval
disjoint with: SequenceLocation
disjoint with: SequenceModificationVocabulary
disjoint with: SequenceRegionVocabulary
disjoint with: SequenceSite
disjoint with: SmallMoleculeReference
disjoint with: Stoichiometry
disjoint with: TissueVocabulary
disjoint with: UnificationXref
disjoint with: Xref
comment: Definition: Imposes ordering on a step in a biochemical pathway. Retionale: A biochemical reaction can be reversible by itself, but can be physiologically directed in the context of a pathway, for instance due to flux of reactants and products. Usage: Only one conversion interaction can be ordered at a time, but multiple catalysis or modulation instances can be part of one step.

BiochemicalReaction
type: Class
subclass of: Conversion
disjoint with: Catalysis
disjoint with: Complex
disjoint with: ComplexAssembly
disjoint with: Control
disjoint with: Degradation
disjoint with: Dna
disjoint with: DnaRegion
disjoint with: Gene
disjoint with: GeneticInteraction
disjoint with: Modulation
disjoint with: Pathway
disjoint with: PhysicalEntity
disjoint with: Protein
disjoint with: Rna
disjoint with: RnaRegion
disjoint with: SmallMolecule
disjoint with: TemplateReactionRegulation
comment: Definition: A conversion in which molecules of one or more physicalEntity pools, undergo covalent modifications and become a member of one or more other physicalEntity pools. The substrates of biochemical reactions are defined in terms of sums of species. This is a convention in biochemistry, and, in principle, all EC reactions should be biochemical reactions. Examples: ATP + H2O = ADP + Pi Comment: In the example reaction above, ATP is considered to be an equilibrium mixture of several species, namely ATP4-, HATP3-, H2ATP2-, MgATP2-, MgHATP-, and Mg2ATP. Additional species may also need to be considered if other ions (e.g. Ca2+) that bind ATP are present. Similar considerations apply to ADP and to inorganic phosphate (Pi). When writing biochemical reactions, it is not necessary to attach charges to the biochemical reactants or to include ions such as H+ and Mg2+ in the equation. The reaction is written in the direction specified by the EC nomenclature system, if applicable, regardless of the physiological direction(s) in which the reaction proceeds. Polymerization reactions involving large polymers whose structure is not explicitly captured should generally be represented as unbalanced reactions in which the monomer is consumed but the polymer remains unchanged, e.g. glycogen + glucose = glycogen. A better coverage for polymerization will be developed.
comment: Definition: An conversion in which molecules of one or more physicalEntity pools undergo covalent modifications and become a member of one or more other physicalEntity pools. The substrates of biochemical reactions are defined in terms of sums of species. This is convention in biochemistry, and, in principle, all of the EC reactions should be biochemical reactions. Examples: ATP + H2O = ADP + Pi Comment: In the example reaction above, ATP is considered to be an equilibrium mixture of several species, namely ATP4-, HATP3-, H2ATP2-, MgATP2-, MgHATP-, and Mg2ATP. Additional species may also need to be considered if other ions (e.g. Ca2+) that bind ATP are present. Similar considerations apply to ADP and to inorganic phosphate (Pi). When writing biochemical reactions, it is not necessary to attach charges to the biochemical reactants or to include ions such as H+ and Mg2+ in the equation. The reaction is written in the direction specified by the EC nomenclature system, if applicable, regardless of the physiological direction(s) in which the reaction proceeds. Polymerization reactions involving large polymers whose structure is not explicitly captured should generally be represented as unbalanced reactions in which the monomer is consumed but the polymer remains unchanged, e.g. glycogen + glucose = glycogen. A better coverage for polymerization is currently being developed.

Catalysis
type: Class
subclass of: Control
subclass of: Restriction
  on property: controlType
  has value: ACTIVATION
subclass of: Restriction
  on property: controller
  all values from: PhysicalEntity
subclass of: Restriction
  on property: controlled
  all values from: Conversion
disjoint with: Complex
disjoint with: ComplexAssembly
disjoint with: Conversion
disjoint with: Degradation
disjoint with: Dna
disjoint with: DnaRegion
disjoint with: Gene
disjoint with: GeneticInteraction
disjoint with: Modulation
disjoint with: MolecularInteraction
disjoint with: Pathway
disjoint with: PhysicalEntity
disjoint with: Protein
disjoint with: Rna
disjoint with: RnaRegion
disjoint with: SmallMolecule
disjoint with: TemplateReaction
disjoint with: TemplateReactionRegulation
disjoint with: Transport
disjoint with: TransportWithBiochemicalReaction
comment: Definition: A control interaction in which a physical entity (a catalyst) increases the rate of a conversion interaction by lowering its activation energy. Instances of this class describe a pairing between a catalyzing entity and a catalyzed conversion. Rationale: Catalysis, theoretically, is always bidirectional since it acts by lowering the activation energy. Physiologically, however, it can have a direction because of the concentration of the participants. For example the oxidative decarboxylation catalyzed by Isocitrate dehydrogenase always happens in one direction under physiological conditions since the produced carbon dioxide is constantly removed from the system. Usage: A separate catalysis instance should be created for each different conversion that a physicalEntity may catalyze and for each different physicalEntity that may catalyze a conversion. For example, a bifunctional enzyme that catalyzes two different biochemical reactions would be linked to each of those biochemical reactions by two separate instances of the catalysis class. Also, catalysis reactions from multiple different organisms could be linked to the same generic biochemical reaction (a biochemical reaction is generic if it only includes small molecules). Generally, the enzyme catalyzing a conversion is known and the use of this class is obvious. In the cases where a catalyzed reaction is known to occur but the enzyme is not known, a catalysis instance can be created without a controller specified. Synonyms: facilitation, acceleration. Examples: The catalysis of a biochemical reaction by an enzyme, the enabling of a transport interaction by a membrane pore complex, and the facilitation of a complex assembly by a scaffold protein. Hexokinase -> (The "Glucose + ATP -> Glucose-6-phosphate +ADP" reaction). A plasma membrane Na+/K+ ATPase is an active transporter (antiport pump) using the energy of ATP to pump Na+ out of the cell and K+ in. Na+ from cytoplasm to extracellular space would be des…
comment: Definition: A control interaction in which a physical entity (a catalyst) increases the rate of a conversion interaction by lowering its activation energy. Instances of this class describe a pairing between a catalyzing entity and a catalyzed conversion. Rationale: Catalysis, theoretically, is always bidirectional since it acts by lowering the activation energy. Physiologically, however, it can have a direction because of the concentration of the participants. For example, the oxidative decarboxylation catalyzed by Isocitrate dehydrogenase always happens in one direction under physiological conditions since the produced carbon dioxide is constantly removed from the system. Usage: A separate catalysis instance should be created for each different conversion that a physicalEntity may catalyze and for each different physicalEntity that may catalyze a conversion. For example, a bifunctional enzyme that catalyzes two different biochemical reactions would be linked to each of those biochemical reactions by two separate instances of the catalysis class. Also, catalysis reactions from multiple different organisms could be linked to the same generic biochemical reaction (a biochemical reaction is generic if it only includes small molecules). Generally, the enzyme catalyzing a conversion is known and the use of this class is obvious, however, in the cases where a catalyzed reaction is known to occur but the enzyme is not known, a catalysis instance can be created without a controller specified. Synonyms: facilitation, acceleration. Examples: The catalysis of a biochemical reaction by an enzyme, the enabling of a transport interaction by a membrane pore complex, and the facilitation of a complex assembly by a scaffold protein. Hexokinase -> (The "Glucose + ATP -> Glucose-6-phosphate +ADP" reaction). A plasma membrane Na+/K+ ATPase is an active transporter (antiport pump) using the energy of ATP to pump Na+ out of the cell and K+ in. Na+ from cytoplasm to extracellular space wo…

CellVocabulary
type: Class
subclass of: ControlledVocabulary
disjoint with: CellularLocationVocabulary
disjoint with: ChemicalStructure
disjoint with: CovalentBindingFeature
disjoint with: DeltaG
disjoint with: DnaReference
disjoint with: DnaRegionReference
disjoint with: EntityFeature
disjoint with: EntityReference
disjoint with: EntityReferenceTypeVocabulary
disjoint with: Evidence
disjoint with: EvidenceCodeVocabulary
disjoint with: ExperimentalForm
disjoint with: ExperimentalFormVocabulary
disjoint with: FragmentFeature
disjoint with: InteractionVocabulary
disjoint with: KPrime
disjoint with: ModificationFeature
disjoint with: PathwayStep
disjoint with: PhenotypeVocabulary
disjoint with: ProteinReference
disjoint with: Provenance
disjoint with: PublicationXref
disjoint with: RelationshipTypeVocabulary
disjoint with: RelationshipXref
disjoint with: RnaReference
disjoint with: RnaRegionReference
disjoint with: Score
disjoint with: SequenceInterval
disjoint with: SequenceLocation
disjoint with: SequenceModificationVocabulary
disjoint with: SequenceRegionVocabulary
disjoint with: SequenceSite
disjoint with: SmallMoleculeReference
disjoint with: Stoichiometry
disjoint with: TissueVocabulary
disjoint with: UnificationXref
disjoint with: Xref
comment: Definition: A reference to the Cell Type Ontology (CL). Homepage at http://obofoundry.org/cgi-bin/detail.cgi?cell. Browse at http://www.ebi.ac.uk/ontology-lookup/browse.do?ontName=CL

CellularLocationVocabulary
type: Class
subclass of: ControlledVocabulary
disjoint with: ChemicalStructure
disjoint with: CovalentBindingFeature
disjoint with: DeltaG
disjoint with: DnaReference
disjoint with: DnaRegionReference
disjoint with: EntityFeature
disjoint with: EntityReference
disjoint with: EntityReferenceTypeVocabulary
disjoint with: Evidence
disjoint with: EvidenceCodeVocabulary
disjoint with: ExperimentalForm
disjoint with: ExperimentalFormVocabulary
disjoint with: FragmentFeature
disjoint with: InteractionVocabulary
disjoint with: KPrime
disjoint with: ModificationFeature
disjoint with: PathwayStep
disjoint with: PhenotypeVocabulary
disjoint with: ProteinReference
disjoint with: Provenance
disjoint with: PublicationXref
disjoint with: RelationshipTypeVocabulary
disjoint with: RelationshipXref
disjoint with: RnaReference
disjoint with: RnaRegionReference
disjoint with: Score
disjoint with: SequenceInterval
disjoint with: SequenceLocation
disjoint with: SequenceModificationVocabulary
disjoint with: SequenceRegionVocabulary
disjoint with: SequenceSite
disjoint with: SmallMoleculeReference
disjoint with: Stoichiometry
disjoint with: TissueVocabulary
disjoint with: UnificationXref
disjoint with: Xref
comment: Definition: A reference to the Gene Ontology Cellular Component (GO CC) ontology. Homepage at http://www.geneontology.org. Browse at http://www.ebi.ac.uk/ontology-lookup/browse.do?ontName=GO

ChemicalStructure
type: Class
subclass of: UtilityClass
subclass of: Restriction
  on property: structureData
  cardinality: 1
subclass of: Restriction
  on property: structureFormat
  cardinality: 1
disjoint with: ControlledVocabulary
disjoint with: CovalentBindingFeature
disjoint with: DeltaG
disjoint with: DnaReference
disjoint with: DnaRegionReference
disjoint with: EntityFeature
disjoint with: EntityReference
disjoint with: EntityReferenceTypeVocabulary
disjoint with: Evidence
disjoint with: EvidenceCodeVocabulary
disjoint with: ExperimentalForm
disjoint with: ExperimentalFormVocabulary
disjoint with: FragmentFeature
disjoint with: InteractionVocabulary
disjoint with: KPrime
disjoint with: ModificationFeature
disjoint with: PathwayStep
disjoint with: PhenotypeVocabulary
disjoint with: ProteinReference
disjoint with: Provenance
disjoint with: PublicationXref
disjoint with: RelationshipTypeVocabulary
disjoint with: RelationshipXref
disjoint with: RnaReference
disjoint with: RnaRegionReference
disjoint with: Score
disjoint with: SequenceInterval
disjoint with: SequenceLocation
disjoint with: SequenceModificationVocabulary
disjoint with: SequenceRegionVocabulary
disjoint with: SequenceSite
disjoint with: SmallMoleculeReference
disjoint with: Stoichiometry
disjoint with: TissueVocabulary
disjoint with: UnificationXref
disjoint with: Xref
comment: Definition: The chemical structure of a small molecule. Usage: Structure information is stored in the property STRUCTURE-DATA, in one of three formats: the CML format (see URL www.xml-cml.org), the SMILES format (see URL www.daylight.com/dayhtml/smiles/) or the InChI format (http://www.iupac.org/inchi/). The STRUCTURE-FORMAT property specifies which format is used. Examples: The following SMILES string describes the structure of glucose-6-phosphate: 'C(OP(=O)(O)O)[CH]1([CH](O)[CH](O)[CH](O)[CH](O)O1)'.
comment: Definition: The chemical structure of a small molecule. Usage: Structure information is stored in the property structureData, in one of three formats: the CML format (see www.xml-cml.org), the SMILES format (see www.daylight.com/dayhtml/smiles/) or the InChI format (http://www.iupac.org/inchi/). The structureFormat property specifies which format is used. Examples: The following SMILES string describes the structure of glucose-6-phosphate: 'C(OP(=O)(O)O)[CH]1([CH](O)[CH](O)[CH](O)[CH](O)O1)'.

Complex
type: Class
subclass of: PhysicalEntity
subclass of: Restriction
  on property: memberPhysicalEntity
  all values from: Complex
disjoint with: ComplexAssembly
disjoint with: Control
disjoint with: Conversion
disjoint with: Degradation
disjoint with: Dna
disjoint with: DnaReference
disjoint with: DnaRegion
disjoint with: DnaRegionReference
disjoint with: EntityReference
disjoint with: Gene
disjoint with: GeneticInteraction
disjoint with: Interaction
disjoint with: Modulation
disjoint with: MolecularInteraction
disjoint with: Pathway
disjoint with: Protein
disjoint with: ProteinReference
disjoint with: Rna
disjoint with: RnaReference
disjoint with: RnaRegion
disjoint with: RnaRegionReference
disjoint with: SmallMolecule
disjoint with: SmallMoleculeReference
disjoint with: TemplateReaction
disjoint with: TemplateReactionRegulation
disjoint with: Transport
disjoint with: TransportWithBiochemicalReaction
comment: Definition: A physical entity whose structure is comprised of other physical entities bound to each other covalently or non-covalently, at least one of which is a macromolecule (e.g. protein, DNA, or RNA) and the Stoichiometry of the components are known. Comment: Complexes must be stable enough to function as a biological unit; in general, the temporary association of an enzyme with its substrate(s) should not be considered or represented as a complex. A complex is the physical product of an interaction (complexAssembly) and is not itself considered an interaction. The boundaries on the size of complexes described by this class are not defined here, although possible, elements of the cell such a mitochondria would typically not be described using this class (later versions of this ontology may include a cellularComponent class to represent these). The strength of binding cannot be described currently, but may be included in future versions of the ontology, depending on community need. Examples: Ribosome, RNA polymerase II. Other examples of this class include complexes of multiple protein monomers and complexes of proteins and small molecules.
comment: Definition: A physical entity whose structure is comprised of other physical entities bound to each other covalently or non-covalently, at least one of which is a macromolecule (e.g. protein, DNA, or RNA). Comment: Complexes must be stable enough to function as a biological unit; in general, the temporary association of an enzyme with its substrate(s) should not be considered or represented as a complex. A complex is the physical product of an interaction (complexAssembly) and is not itself considered an interaction. The boundaries on the size of complexes described by this class are not defined here, although elements of the cell as large and dynamic as, e.g., a mitochondrion would typically not be described using this class (later versions of this ontology may include a cellularComponent class to represent these). The strength of binding cannot be described currently, but may be included in future versions of the ontology, depending on community need. Examples: Ribosome, RNA polymerase II. Other examples of this class include complexes of multiple protein monomers and complexes of proteins and small molecules.

ComplexAssembly
type: Class
subclass of: Conversion
disjoint with: Control
disjoint with: Degradation
disjoint with: Dna
disjoint with: DnaRegion
disjoint with: Gene
disjoint with: GeneticInteraction
disjoint with: Modulation
disjoint with: Pathway
disjoint with: PhysicalEntity
disjoint with: Protein
disjoint with: Rna
disjoint with: RnaRegion
disjoint with: SmallMolecule
disjoint with: TemplateReactionRegulation
disjoint with: Transport
disjoint with: TransportWithBiochemicalReaction
comment: Definition: A conversion in which a set of physical entities, at least one being a macromolecule (e.g. protein, RNA, DNA), aggregate. This modification is captured via BindingFeature class. One of the participants of a complexAssembly must be an instance of the class Complex. Usage: This class is also used to represent complex disassembly. The assembly or disassembly of a complex is often a spontaneous process, in which case the direction of the complexAssembly (toward either assembly or disassembly) should be specified via the SPONTANEOUS property. Conversions in which participants obtain or lose CovalentBindingFeatures ( e.g. glycolysation of proteins) should be modeled with BiochemicalReaction. Synonyms: aggregation, complex formation Examples: Assembly of the TFB2 and TFB3 proteins into the TFIIH complex, and assembly of the ribosome through aggregation of its subunits.
comment: Definition: A conversion interaction in which a set of physical entities, at least one being a macromolecule (e.g. protein, RNA, DNA), aggregate to from a complex physicalEntity. One of the participants of a complexAssembly must be an instance of the class Complex. The modification of the physicalentities involved in the ComplexAssembly is captured via BindingFeature class. Usage: This class is also used to represent complex disassembly. The assembly or disassembly of a complex is often a spontaneous process, in which case the direction of the complexAssembly (toward either assembly or disassembly) should be specified via the SPONTANEOUS property. Conversions in which participants obtain or lose CovalentBindingFeatures ( e.g. glycolysation of proteins) should be modeled with BiochemicalReaction. Synonyms: aggregation, complex formation Examples: Assembly of the TFB2 and TFB3 proteins into the TFIIH complex, and assembly of the ribosome through aggregation of its subunits.

Control
type: Class
subclass of: Interaction
disjoint with: Conversion
disjoint with: Degradation
disjoint with: Dna
disjoint with: DnaRegion
disjoint with: Gene
disjoint with: GeneticInteraction
disjoint with: MolecularInteraction
disjoint with: Pathway
disjoint with: PhysicalEntity
disjoint with: Protein
disjoint with: Rna
disjoint with: RnaRegion
disjoint with: SmallMolecule
disjoint with: TemplateReaction
disjoint with: Transport
disjoint with: TransportWithBiochemicalReaction
comment: Definition: An interaction in which one entity regulates, modifies, or otherwise influences a continuant entity, i.e. pathway or interaction. Usage: Conceptually, physical entities are involved in interactions (or events) and the events are controlled or modified, not the physical entities themselves. For example, a kinase activating a protein is a frequent event in signaling pathways and is usually represented as an 'activation' arrow from the kinase to the substrate in signaling diagrams. This is an abstraction, called "Activity Flow" representation, that can be ambiguous without context. In BioPAX, this information should be captured as the kinase catalyzing (via an instance of the catalysis class) a Biochemical Reaction in which the substrate is phosphorylated. Subclasses of control define types specific to the biological process that is being controlled and should be used instead of the generic "control" class when applicable. A control can potentially have multiple controllers. This acts as a logical AND, i.e. both controllers are needed to regulate the controlled event. Alternatively multiple controllers can control the same event and this acts as a logical OR, i.e. any one of them is sufficient to regulate the controlled event. Using this structure it is possible to describe arbitrary control logic using BioPAX. Rationale: Control can be temporally non-atomic, for example a pathway can control another pathway in BioPAX. Synonyms: regulation, mediation Examples: A small molecule that inhibits a pathway by an unknown mechanism.
comment: Definition: An interaction in which one entity regulates, modifies, or otherwise influences a continuant entity, i.e. pathway or interaction. Usage: Conceptually, physical entities are involved in interactions (or events) and the events should be controlled or modified, not the physical entities themselves. For example, a kinase activating a protein is a frequent event in signaling pathways and is usually represented as an 'activation' arrow from the kinase to the substrate in signaling diagrams. This is an abstraction, called "Activity Flow" representation, that can be ambiguous without context. In BioPAX, this information should be captured as the kinase catalyzing (via an instance of the catalysis class) a Biochemical Reaction in which the substrate is phosphorylated. Subclasses of control define types specific to the biological process that is being controlled and should be used instead of the generic "control" class when applicable. A control can potentially have multiple controllers. This acts as a logical AND, i.e. both controllers are needed to regulate the controlled event. Alternatively multiple controllers can control the same event and this acts as a logical OR, i.e. any one of them is sufficient to regulate the controlled event. Using this structure it is possible to describe arbitrary control logic using BioPAX. Rationale: Control can be temporally non-atomic, for example a pathway can control another pathway in BioPAX. Synonyms: regulation, mediation Examples: A small molecule that inhibits a pathway by an unknown mechanism.

ControlledVocabulary
type: Class
subclass of: UtilityClass
subclass of: Restriction
  on property: Xref
  all values from: UnificationXref
subclass of: Restriction
  on property: xref
  all values from: UnificationXref
disjoint with: CovalentBindingFeature
disjoint with: DeltaG
disjoint with: DnaReference
disjoint with: DnaRegionReference
disjoint with: EntityFeature
disjoint with: EntityReference
disjoint with: Evidence
disjoint with: ExperimentalForm
disjoint with: FragmentFeature
disjoint with: KPrime
disjoint with: ModificationFeature
disjoint with: PathwayStep
disjoint with: ProteinReference
disjoint with: Provenance
disjoint with: PublicationXref
disjoint with: RelationshipXref
disjoint with: RnaReference
disjoint with: RnaRegionReference
disjoint with: Score
disjoint with: SequenceInterval
disjoint with: SequenceLocation
disjoint with: SequenceSite
disjoint with: SmallMoleculeReference
disjoint with: Stoichiometry
disjoint with: UnificationXref
disjoint with: Xref
comment: Definition: This class represents a term from an external controlled vocabulary (CV). Rationale: Controlled Vocabularies mark cases where BioPAX delegates the representation of a complex biological phenomena to an external controlled vocabulary development effort such as Gene Ontology. Each subclass of this class represents one such case and often has an associated "Best-Practice" external resource to use. See the documentation of each subclass for more specific information. Correct usage of controlled vocabularies are critical to data exchange and integration. Usage: The individuals belonging to this class must unambiguously refer to the source controlled vocabulary. This can be achieved in two manners: The xref property of this class is restricted to the unification xref class. It must point to the source controlled vocabulary. Alternatively the rdf-id of the member individuals can be set to the designated MIRIAM URN. It is a best practice to do both whenever possible. Although it is possible to use multiple unification xrefs to identify semantically identical terms across alternative controlled vocabularies, this is not a recommended practice as it might lead to maintenance issues as the controlled vocabularies change. There is no recommended use-case for directly instantiating this class. Please use its subclasses instead.

Conversion
type: Class
subclass of: Interaction
subclass of: Restriction
  on property: participant
  all values from: PhysicalEntity
disjoint with: Dna
disjoint with: DnaRegion
disjoint with: Gene
disjoint with: GeneticInteraction
disjoint with: Modulation
disjoint with: Pathway
disjoint with: PhysicalEntity
disjoint with: Protein
disjoint with: Rna
disjoint with: RnaRegion
disjoint with: SmallMolecule
disjoint with: TemplateReactionRegulation
comment: Definition: An interaction in which molecules of one or more PhysicalEntity pools are physically transformed and become a member of one or more other PhysicalEntity pools. Rationale: Conversion is Comments: Conversions in BioPAX are stoichiometric and closed world, i.e. it is assumed that all of the participants are listed. Both properties are due to the law of mass conservation. Usage: Subclasses of conversion represent different types of transformation reflected by the properties of different physicalEntity. BiochemicalReactions will change the ModificationFeatures on a PhysicalEntity, Transport will change the Cellular Location and ComplexAssembly will change BindingFeatures. Generic Conversion class should only be used when the modification does not fit into a any of these classes. Example: Opening of a voltage gated channel.
comment: Definition: An interaction in which molecules of one or more physicalEntity pools are physically transformed and become a member of one or more other physicalEntity pools. Comments: Conversions in BioPAX are stoichiometric and closed world, i.e. i is assumed that all of the participants are listed. Both properties are due to the law of mass conservation. Usage: Subclasses of conversion represent different types of transformation reflected by different physicalEntity properties. BiochemicalReaction will change the ModificationFeatures on the PhysicalEntity , Transport will change the CellularLocation and ComplexAssembly will change the BindingFeature. Generic Conversion class should only be used when the modification does not fit into one of these classes. Example: Opening of a voltage gated channel.

CovalentBindingFeature
type: Class
subclass of: BindingFeature
subclass of: ModificationFeature
disjoint with: DeltaG
disjoint with: DnaReference
disjoint with: DnaRegionReference
disjoint with: EntityReference
disjoint with: EntityReferenceTypeVocabulary
disjoint with: Evidence
disjoint with: EvidenceCodeVocabulary
disjoint with: ExperimentalForm
disjoint with: ExperimentalFormVocabulary
disjoint with: FragmentFeature
disjoint with: InteractionVocabulary
disjoint with: KPrime
disjoint with: PathwayStep
disjoint with: PhenotypeVocabulary
disjoint with: ProteinReference
disjoint with: Provenance
disjoint with: PublicationXref
disjoint with: RelationshipTypeVocabulary
disjoint with: RelationshipXref
disjoint with: RnaReference
disjoint with: RnaRegionReference
disjoint with: Score
disjoint with: SequenceInterval
disjoint with: SequenceLocation
disjoint with: SequenceModificationVocabulary
disjoint with: SequenceRegionVocabulary
disjoint with: SequenceSite
disjoint with: SmallMoleculeReference
disjoint with: Stoichiometry
disjoint with: TissueVocabulary
disjoint with: UnificationXref
disjoint with: Xref
comment: Definition : An entity feature that represent the covalently bound state of a physical entity. Rationale: Most frequent covalent modifications to proteins and DNA, such as phosphorylation and metylation are covered by the ModificationFeature class. In these cases, the added groups are simple and stateless therefore they can be captured by a controlled vocabulary. In other cases, such as ThiS-Thilacyl-disulfide, the covalently linked molecules are best represented as a molecular complex. CovalentBindingFeature should be used to model such covalently linked complexes. Usage: Using this construct, it is possible to represent small molecules as a covalent complex of two other small molecules. The demarcation of small molecules is a general problem and is delegated to small molecule databases.The best practice is not to model using covalent complexes unless at least one of the participants is a protein, DNA or RNA. Examples: disulfide bond UhpC + glc-6P -> Uhpc-glc-6p acetyl-ACP -> decenoyl-ACP charged tRNA

Degradation
type: Class
subclass of: Conversion
subclass of: Restriction
  on property: conversionDirection
  has value: LEFT-TO-RIGHT
disjoint with: Dna
disjoint with: DnaRegion
disjoint with: Gene
disjoint with: GeneticInteraction
disjoint with: Modulation
disjoint with: Pathway
disjoint with: PhysicalEntity
disjoint with: Protein
disjoint with: Rna
disjoint with: RnaRegion
disjoint with: SmallMolecule
disjoint with: TemplateReactionRegulation
disjoint with: Transport
disjoint with: TransportWithBiochemicalReaction
comment: Definition: A conversion in which a pool of macromolecules are degraded into their elementary units. Usage: This conversion always has a direction of left-to-right and is irreversible. Degraded molecules are always represented on the left, degradation products on the right. Comments: Degradation is a complex abstraction over multiple reactions. Although it obeys law of mass conservation and stoichiometric, the products are rarely specified since they are ubiquitous. Example: Degradation of a protein to amino acids.
comment: Definition: A conversion in which a pool of macromolecules are degraded into their ubiquitous elementary subunits. Usage: This conversion always has a direction of left-to-right and is irreversible. Degraded molecules are always represented on the left, degradation products on the right. Comments: Degradation is a complex abstraction over multiple reactions. Although it obeys law of mass conservation and stoichiometric, the products are rarely specified since they are ubiquitous. Example: Degradation of a protein to amino acids.

DeltaG
type: Class
subclass of: UtilityClass
subclass of: Restriction
  on property: deltaGPrime0
  cardinality: 1
disjoint with: DnaReference
disjoint with: DnaRegionReference
disjoint with: EntityFeature
disjoint with: EntityReference
disjoint with: EntityReferenceTypeVocabulary
disjoint with: Evidence
disjoint with: EvidenceCodeVocabulary
disjoint with: ExperimentalForm
disjoint with: ExperimentalFormVocabulary
disjoint with: FragmentFeature
disjoint with: InteractionVocabulary
disjoint with: KPrime
disjoint with: ModificationFeature
disjoint with: PathwayStep
disjoint with: PhenotypeVocabulary
disjoint with: ProteinReference
disjoint with: Provenance
disjoint with: PublicationXref
disjoint with: RelationshipTypeVocabulary
disjoint with: RelationshipXref
disjoint with: RnaReference
disjoint with: RnaRegionReference
disjoint with: Score
disjoint with: SequenceInterval
disjoint with: SequenceLocation
disjoint with: SequenceModificationVocabulary
disjoint with: SequenceRegionVocabulary
disjoint with: SequenceSite
disjoint with: SmallMoleculeReference
disjoint with: Stoichiometry
disjoint with: TissueVocabulary
disjoint with: UnificationXref
disjoint with: Xref
comment: Definition: Standard transformed Gibbs energy change for a reaction written in terms of biochemical reactants. Usage: Delta-G is represented as a 5-tuple of delta-G'0, temperature, ionic strength , pH, and pMg . A conversion in BioPAX may have multiple Delta-G values, representing different measurements for delta-G'0 obtained under the different experimental conditions.

Dna
type: Class
subclass of: PhysicalEntity
subclass of: Restriction
  on property: entityReference
  all values from: DnaReference
subclass of: Restriction
  on property: memberPhysicalEntity
  all values from: Dna
disjoint with: DnaReference
disjoint with: DnaRegion
disjoint with: DnaRegionReference
disjoint with: EntityReference
disjoint with: Gene
disjoint with: GeneticInteraction
disjoint with: Interaction
disjoint with: Modulation
disjoint with: MolecularInteraction
disjoint with: Pathway
disjoint with: Protein
disjoint with: ProteinReference
disjoint with: Rna
disjoint with: RnaReference
disjoint with: RnaRegion
disjoint with: RnaRegionReference
disjoint with: SmallMolecule
disjoint with: SmallMoleculeReference
disjoint with: TemplateReaction
disjoint with: TemplateReactionRegulation
disjoint with: Transport
disjoint with: TransportWithBiochemicalReaction
comment: Definition: A physical entity consisting of a sequence of deoxyribonucleotide monophosphates; a deoxyribonucleic acid. Usage: DNA should be used for pools of individual DNA molecules. For describing subregions on those molecules use DNARegion. Examples: a chromosome, a plasmid. A specific example is chromosome 7 of Homo sapiens.

DnaReference
type: Class
subclass of: EntityReference
subclass of: Restriction
  on property: subRegion
  all values from: DnaRegionReference
subclass of: Restriction
  on property: memberEntityReference
  all values from: DnaReference
disjoint with: DnaRegion
disjoint with: DnaRegionReference
disjoint with: EntityFeature
disjoint with: EntityReferenceTypeVocabulary
disjoint with: Evidence
disjoint with: EvidenceCodeVocabulary
disjoint with: ExperimentalForm
disjoint with: ExperimentalFormVocabulary
disjoint with: FragmentFeature
disjoint with: InteractionVocabulary
disjoint with: KPrime
disjoint with: ModificationFeature
disjoint with: PathwayStep
disjoint with: PhenotypeVocabulary
disjoint with: PhysicalEntity
disjoint with: Protein
disjoint with: ProteinReference
disjoint with: Provenance
disjoint with: PublicationXref
disjoint with: RelationshipTypeVocabulary
disjoint with: RelationshipXref
disjoint with: Rna
disjoint with: RnaReference
disjoint with: RnaRegion
disjoint with: RnaRegionReference
disjoint with: Score
disjoint with: SequenceInterval
disjoint with: SequenceLocation
disjoint with: SequenceModificationVocabulary
disjoint with: SequenceRegionVocabulary
disjoint with: SequenceSite
disjoint with: SmallMolecule
disjoint with: SmallMoleculeReference
disjoint with: Stoichiometry
disjoint with: TissueVocabulary
disjoint with: UnificationXref
disjoint with: Xref
comment: Definition: A DNA reference is a grouping of several DNA entities that are common in sequence. Members can differ in celular location, sequence features, SNPs, mutations and bound partners. Comments : Note that this is not a reference gene. Genes are non-physical,stateless continuants. Their physical manifestations can span multiple DNA molecules, sometimes even across chromosomes due to regulatory regions. Similarly a gene is not necessarily made up of deoxyribonucleic acid and can be present in multiple copies ( which are different DNA regions).

DnaRegion
type: Class
subclass of: PhysicalEntity
subclass of: Restriction
  on property: memberPhysicalEntity
  all values from: DnaRegion
subclass of: Restriction
  on property: entityReference
  all values from: DnaRegionReference
disjoint with: DnaRegionReference
disjoint with: EntityReference
disjoint with: Gene
disjoint with: GeneticInteraction
disjoint with: Interaction
disjoint with: Modulation
disjoint with: MolecularInteraction
disjoint with: Pathway
disjoint with: Protein
disjoint with: ProteinReference
disjoint with: Rna
disjoint with: RnaReference
disjoint with: RnaRegion
disjoint with: RnaRegionReference
disjoint with: SmallMolecule
disjoint with: SmallMoleculeReference
disjoint with: TemplateReaction
disjoint with: TemplateReactionRegulation
disjoint with: Transport
disjoint with: TransportWithBiochemicalReaction
comment: Definition: A region on a DNA molecule. Usage: DNARegion is not a pool of independent molecules but a subregion on these molecules. As such, every DNARegion has a defining DNA molecule. Examples: Protein encoding region, promoter
comment: Definition: A region on a DNA molecule. Usage: DNARegion is not a pool of independent molecules but a subregion on these molecules. As such, every DNARegion has a defining DNA molecule. Examples: Proteing encoding region, promoter

DnaRegionReference
type: Class
subclass of: EntityReference
subclass of: Restriction
  on property: subRegion
  all values from: DnaRegionReference
disjoint with: EntityFeature
disjoint with: EntityReferenceTypeVocabulary
disjoint with: Evidence
disjoint with: EvidenceCodeVocabulary
disjoint with: ExperimentalForm
disjoint with: ExperimentalFormVocabulary
disjoint with: FragmentFeature
disjoint with: InteractionVocabulary
disjoint with: KPrime
disjoint with: ModificationFeature
disjoint with: PathwayStep
disjoint with: PhenotypeVocabulary
disjoint with: PhysicalEntity
disjoint with: Protein
disjoint with: ProteinReference
disjoint with: Provenance
disjoint with: PublicationXref
disjoint with: RelationshipTypeVocabulary
disjoint with: RelationshipXref
disjoint with: Rna
disjoint with: RnaReference
disjoint with: RnaRegion
disjoint with: RnaRegionReference
disjoint with: Score
disjoint with: SequenceInterval
disjoint with: SequenceLocation
disjoint with: SequenceModificationVocabulary
disjoint with: SequenceRegionVocabulary
disjoint with: SequenceSite
disjoint with: SmallMolecule
disjoint with: SmallMoleculeReference
disjoint with: Stoichiometry
disjoint with: TissueVocabulary
disjoint with: UnificationXref
disjoint with: Xref
comment: Definition: A DNA reference is a grouping of several DNA entities that are common in sequence and genomic position. Members can differ in celular location, sequence features, SNPs, mutations and bound partners.
comment: Definition: A DNARegionReference is a grouping of several DNARegion entities that are common in sequence and genomic position. Members can differ in cellular location, sequence features, SNPs, mutations and bound partners.

Entity
type: Class
comment: Definition: A discrete biological unit used when describing pathways. Rationale: Entity is the most abstract class for representing components of a pathway. It includes both occurents (interactions and pathways) and continuants (physical entities and genes). Loosely speaking, BioPAX Entity is an atomic scientific statement with an associated source, evidence and references. Usage: There is no recommended use-cases for instantiating this class. Please, use its subclasses instead. Synonyms: element, thing,biological unit, statement, observable.
comment: Definition: A discrete biological unit used when describing pathways. Rationale: Entity is the most abstract class for representing interacting elements in a pathway. It includes both occurents (interactions and pathways) and continuants (physical entities and genes). Loosely speaking, BioPAX Entity is an atomic scientific statement with an associated source, evidence and references. Synonyms: element, thing, object, bioentity, statement.

EntityFeature
type: Class
subclass of: UtilityClass
disjoint with: EntityReference
disjoint with: EntityReferenceTypeVocabulary
disjoint with: Evidence
disjoint with: EvidenceCodeVocabulary
disjoint with: ExperimentalForm
disjoint with: ExperimentalFormVocabulary
disjoint with: InteractionVocabulary
disjoint with: KPrime
disjoint with: PathwayStep
disjoint with: PhenotypeVocabulary
disjoint with: ProteinReference
disjoint with: Provenance
disjoint with: PublicationXref
disjoint with: RelationshipTypeVocabulary
disjoint with: RelationshipXref
disjoint with: RnaReference
disjoint with: RnaRegionReference
disjoint with: Score
disjoint with: SequenceInterval
disjoint with: SequenceLocation
disjoint with: SequenceModificationVocabulary
disjoint with: SequenceRegionVocabulary
disjoint with: SequenceSite
disjoint with: SmallMoleculeReference
disjoint with: Stoichiometry
disjoint with: TissueVocabulary
disjoint with: UnificationXref
disjoint with: Xref
comment: Description: A characteristic of a physical entity that can change while the entity still retains its biological identity. Rationale: Two phosphorylated forms of a protein are strictly speaking different chemical molecules. It is, however, standard in biology to treat them as different states of the same entity, where the entity is loosely defined based on sequence. Entity Feature class and its subclassses captures these variable characteristics. A Physical Entity in BioPAX represents a pool of molecules rather than an individual molecule. This is a notion imported from chemistry( See PhysicalEntity). Pools are defined by a set of Entity Features in the sense that a single molecule must have all of the features in the set in order to be considered a member of the pool. Since it is impossible to list and experimentally test all potential features for an entity, features that are not listed in the selection criteria is neglected Pools can also be defined by the converse by specifying features that are known to NOT exist in a specific context. As DNA, RNA and Proteins can be hierarchically organized into families based on sequence homology so can entity features. The memberFeature property allows capturing such hierarchical classifications among entity features. Usage: Subclasses of entity feature describe most common biological instances and should be preferred whenever possible. One common usecase for instantiating entity feature is, for describing active/inactive states of proteins where more specific feature information is not available. Examples: Open/close conformational state of channel proteins, "active"/"inactive" states, excited states of photoreactive groups.
comment: Description: A characteristic of a physical entity that can change while the entity still retains its biological identity. Rationale: Two phosphorylated forms of a protein are strictly speaking different chemical molecules. It is, however, standard in biology to treat them as different states of the same entity, where the entity is loosely defined based on sequence. Entity Feature class and its subclassses captures these variable characteristics. A Physical Entity in BioPAX represents a pool of molecules rather than an individual molecule. This is a notion imported from chemistry( See PhysicalEntity). Pools are defined by a set of Entity Features in the sense that a single molecule must have all of the features in the set in order to be considered a member of the pool. Since it is impossible to list and experimentally test all potential features for an entity, features that are not listed in the selection criteria is neglected Pools can also be defined by the converse by specifying features that are known to NOT exist in a specific context. As DNA, RNA and Proteins can be hierarchicaly organized into families based on sequence homology so can entity features. The memberFeature property allows capturing such hierarchical classifications among entity features. Usage: Subclasses of entity feature describe most common biological instances and sholud be preferred whenever possible. One common usecase for instatiating entity feature is, for describing active/inactive states of proteins where more specific feature information is not available. Instances: Open/close conformational state of channel proteins, "active"/"inactive" states, excited states of photoreactive groups.

EntityReference
type: Class
subclass of: UtilityClass
disjoint with: EntityReferenceTypeVocabulary
disjoint with: Evidence
disjoint with: EvidenceCodeVocabulary
disjoint with: ExperimentalForm
disjoint with: ExperimentalFormVocabulary
disjoint with: FragmentFeature
disjoint with: InteractionVocabulary
disjoint with: KPrime
disjoint with: ModificationFeature
disjoint with: PathwayStep
disjoint with: PhenotypeVocabulary
disjoint with: PhysicalEntity
disjoint with: Protein
disjoint with: Provenance
disjoint with: PublicationXref
disjoint with: RelationshipTypeVocabulary
disjoint with: RelationshipXref
disjoint with: Rna
disjoint with: RnaRegion
disjoint with: Score
disjoint with: SequenceInterval
disjoint with: SequenceLocation
disjoint with: SequenceModificationVocabulary
disjoint with: SequenceRegionVocabulary
disjoint with: SequenceSite
disjoint with: SmallMolecule
disjoint with: Stoichiometry
disjoint with: TissueVocabulary
disjoint with: UnificationXref
disjoint with: Xref
comment: Definition: An entity reference is a grouping of several physical entities across different contexts and molecular states, that share common physical properties and often named and treated as a single entity with multiple states by biologists. Rationale: Many protein, small molecule and gene databases share this point of view, and such a grouping is an important prerequisite for interoperability with those databases. Biologists would often group different pools of molecules in different contexts under the same name. For example cytoplasmic and extracellular calcium have different effects on the cell's behavior, but they are still called calcium. For DNA, RNA and Proteins the grouping is defined based on a wildtype sequence, for small molecules it is defined by the chemical structure. Usage: Entity references store the information common to a set of molecules in various states described in the BioPAX document, including database cross-references. For instance, the P53 protein can be phosphorylated in multiple different ways. Each separate P53 protein (pool) in a phosphorylation state would be represented as a different protein (child of physicalEntity) and all things common to all P53 proteins, including all possible phosphorylation sites, the sequence common to all of them and common references to protein databases containing more information about P53 would be stored in a Entity Reference. Comments: This grouping has three semantic implications: 1. Members of different pools share many physical and biochemical properties. This includes their chemical structure, sequence, organism and set of molecules they react with. They will also share a lot of secondary information such as their names, functional groupings, annotation terms and database identifiers. 2. A small number of transitions seperates these pools. In other words it is relatively easy and frequent for a molecule to transform from one physical entity to another that belong to the same reference entity. For …

EntityReferenceTypeVocabulary
type: Class
subclass of: ControlledVocabulary
disjoint with: Evidence
disjoint with: EvidenceCodeVocabulary
disjoint with: ExperimentalForm
disjoint with: ExperimentalFormVocabulary
disjoint with: FragmentFeature
disjoint with: InteractionVocabulary
disjoint with: KPrime
disjoint with: ModificationFeature
disjoint with: PathwayStep
disjoint with: PhenotypeVocabulary
disjoint with: ProteinReference
disjoint with: Provenance
disjoint with: PublicationXref
disjoint with: RelationshipTypeVocabulary
disjoint with: RelationshipXref
disjoint with: RnaReference
disjoint with: RnaRegionReference
disjoint with: Score
disjoint with: SequenceInterval
disjoint with: SequenceLocation
disjoint with: SequenceModificationVocabulary
disjoint with: SequenceRegionVocabulary
disjoint with: SequenceSite
disjoint with: SmallMoleculeReference
disjoint with: Stoichiometry
disjoint with: TissueVocabulary
disjoint with: UnificationXref
disjoint with: Xref
comment: Definiiton: A reference to a term from a reference entity group ontology. There is no "best-practice" vocabulary for this one.
comment: Definiiton: A reference to a term from an entity reference group ontology. As of the writing of this documentation, there is no standard ontology of these terms, though a common type is ‘homology’.

Evidence
type: Class
subclass of: UtilityClass
subclass of: Class
  union of: Restriction
    on property: confidence
    min cardinality: 1
  union of: Restriction
    on property: evidenceCode
    min cardinality: 1
  union of: Restriction
    on property: experimentalForm
    min cardinality: 1
disjoint with: EvidenceCodeVocabulary
disjoint with: ExperimentalForm
disjoint with: ExperimentalFormVocabulary
disjoint with: FragmentFeature
disjoint with: InteractionVocabulary
disjoint with: KPrime
disjoint with: ModificationFeature
disjoint with: PathwayStep
disjoint with: PhenotypeVocabulary
disjoint with: ProteinReference
disjoint with: Provenance
disjoint with: PublicationXref
disjoint with: RelationshipTypeVocabulary
disjoint with: RelationshipXref
disjoint with: RnaReference
disjoint with: RnaRegionReference
disjoint with: Score
disjoint with: SequenceInterval
disjoint with: SequenceLocation
disjoint with: SequenceModificationVocabulary
disjoint with: SequenceRegionVocabulary
disjoint with: SequenceSite
disjoint with: SmallMoleculeReference
disjoint with: Stoichiometry
disjoint with: TissueVocabulary
disjoint with: UnificationXref
disjoint with: Xref
comment: Definition: The support for a particular assertion, such as the existence of an interaction or pathway. Usage: At least one of CONFIDENCE, EVIDENCE-CODE, or EXPERIMENTAL-FORM must be instantiated when creating an evidence instance. XREF may reference a publication describing the experimental evidence using a publicationXref or may store a description of the experiment in an experimental description database using a unificationXref (if the referenced experiment is the same) or relationshipXref (if it is not identical, but similar in some way e.g. similar in protocol). Evidence is meant to provide more information than just an xref to the source paper. Examples: A description of a molecular binding assay that was used to detect a protein-protein interaction.
comment: Definition: The support for a particular assertion, such as the existence of an interaction or pathway. Usage: At least one of confidence, evidenceCode, or experimentalForm must be instantiated when creating an evidence instance. XREF may reference a publication describing the experimental evidence using a publicationXref or may store a description of the experiment in an experimental description database using a unificationXref (if the referenced experiment is the same) or relationshipXref (if it is not identical, but similar in some way e.g. similar in protocol). Evidence is meant to provide more information than just an xref to the source paper. Examples: A description of a molecular binding assay that was used to detect a protein-protein interaction.

EvidenceCodeVocabulary
type: Class
subclass of: ControlledVocabulary
disjoint with: ExperimentalForm
disjoint with: ExperimentalFormVocabulary
disjoint with: FragmentFeature
disjoint with: InteractionVocabulary
disjoint with: KPrime
disjoint with: ModificationFeature
disjoint with: PathwayStep
disjoint with: PhenotypeVocabulary
disjoint with: ProteinReference
disjoint with: Provenance
disjoint with: PublicationXref
disjoint with: RelationshipTypeVocabulary
disjoint with: RelationshipXref
disjoint with: RnaReference
disjoint with: RnaRegionReference
disjoint with: Score
disjoint with: SequenceInterval
disjoint with: SequenceLocation
disjoint with: SequenceModificationVocabulary
disjoint with: SequenceRegionVocabulary
disjoint with: SequenceSite
disjoint with: SmallMoleculeReference
disjoint with: Stoichiometry
disjoint with: TissueVocabulary
disjoint with: UnificationXref
disjoint with: Xref
comment: Definition: A reference to the PSI Molecular Interaction ontology (MI) experimental method types, including "interaction detection method", "participant identification method", "feature detection method". Homepage at http://www.psidev.info/. Browse at http://www.ebi.ac.uk/ontology-lookup/browse.do?ontName=MI Terms from the Pathway Tools Evidence Ontology may also be used. Homepage http://brg.ai.sri.com/evidence-ontology/

ExperimentalForm
type: Class
subclass of: UtilityClass
subclass of: Restriction
  on property: experimentalFormDescription
  min cardinality: 1
disjoint with: ExperimentalFormVocabulary
disjoint with: FragmentFeature
disjoint with: InteractionVocabulary
disjoint with: KPrime
disjoint with: ModificationFeature
disjoint with: PathwayStep
disjoint with: PhenotypeVocabulary
disjoint with: ProteinReference
disjoint with: Provenance
disjoint with: PublicationXref
disjoint with: RelationshipTypeVocabulary
disjoint with: RelationshipXref
disjoint with: RnaReference
disjoint with: RnaRegionReference
disjoint with: Score
disjoint with: SequenceInterval
disjoint with: SequenceLocation
disjoint with: SequenceModificationVocabulary
disjoint with: SequenceRegionVocabulary
disjoint with: SequenceSite
disjoint with: SmallMoleculeReference
disjoint with: Stoichiometry
disjoint with: TissueVocabulary
disjoint with: UnificationXref
disjoint with: Xref
comment: Definition: The form of a physical entity in a particular experiment, as it may be modified for purposes of experimental design. Examples: A His-tagged protein in a binding assay. A protein can be tagged by multiple tags, so can have more than 1 experimental form type terms

ExperimentalFormVocabulary
type: Class
subclass of: ControlledVocabulary
disjoint with: FragmentFeature
disjoint with: InteractionVocabulary
disjoint with: KPrime
disjoint with: ModificationFeature
disjoint with: PathwayStep
disjoint with: PhenotypeVocabulary
disjoint with: ProteinReference
disjoint with: Provenance
disjoint with: PublicationXref
disjoint with: RelationshipTypeVocabulary
disjoint with: RelationshipXref
disjoint with: RnaReference
disjoint with: RnaRegionReference
disjoint with: Score
disjoint with: SequenceInterval
disjoint with: SequenceLocation
disjoint with: SequenceModificationVocabulary
disjoint with: SequenceRegionVocabulary
disjoint with: SequenceSite
disjoint with: SmallMoleculeReference
disjoint with: Stoichiometry
disjoint with: TissueVocabulary
disjoint with: UnificationXref
disjoint with: Xref
comment: Definition: A reference to the PSI Molecular Interaction ontology (MI) participant identification method (e.g. mass spectrometry), experimental role (e.g. bait, prey), experimental preparation (e.g. expression level) type. Homepage at http://www.psidev.info/. Browse http://www.ebi.ac.uk/ontology-lookup/browse.do?ontName=MI&termId=MI%3A0002&termName=participant%20identification%20method http://www.ebi.ac.uk/ontology-lookup/browse.do?ontName=MI&termId=MI%3A0495&termName=experimental%20role http://www.ebi.ac.uk/ontology-lookup/browse.do?ontName=MI&termId=MI%3A0346&termName=experimental%20preparation

FragmentFeature
type: Class
subclass of: EntityFeature
disjoint with: InteractionVocabulary
disjoint with: KPrime
disjoint with: ModificationFeature
disjoint with: PathwayStep
disjoint with: PhenotypeVocabulary
disjoint with: ProteinReference
disjoint with: Provenance
disjoint with: PublicationXref
disjoint with: RelationshipTypeVocabulary
disjoint with: RelationshipXref
disjoint with: RnaReference
disjoint with: RnaRegionReference
disjoint with: Score
disjoint with: SequenceInterval
disjoint with: SequenceLocation
disjoint with: SequenceModificationVocabulary
disjoint with: SequenceRegionVocabulary
disjoint with: SequenceSite
disjoint with: SmallMoleculeReference
disjoint with: Stoichiometry
disjoint with: TissueVocabulary
disjoint with: UnificationXref
disjoint with: Xref
comment: Definition: An entity feature that represents the resulting physical entity subsequent to a cleavage or degradation event. Usage: Fragment Feature can be used to cover multiple types of modfications to the sequence of the physical entity: 1. A protein with a single cleavage site that converts the protein into two fragments (e.g. pro-insulin converted to insulin and C-peptide). TODO: CV term for sequence fragment? PSI-MI CV term for cleavage site? 2. A protein with two cleavage sites that removes an internal sequence e.g. an intein i.e. ABC -> A 3. Cleavage of a circular sequence e.g. a plasmid. In the case of removal ( e.g. intron) the fragment that is *removed* is specified in the feature location property. In the case of a "cut" (e.g. restriction enzyme cut site) the location of the cut is specified instead. Examples: Insulin Hormone

Gene
type: Class
subclass of: Entity
subclass of: Restriction
  on property: organism
  max cardinality: 1
disjoint with: GeneticInteraction
disjoint with: Interaction
disjoint with: Modulation
disjoint with: MolecularInteraction
disjoint with: Pathway
disjoint with: PhysicalEntity
disjoint with: Protein
disjoint with: Rna
disjoint with: RnaRegion
disjoint with: SmallMolecule
disjoint with: TemplateReaction
disjoint with: TemplateReactionRegulation
disjoint with: Transport
disjoint with: TransportWithBiochemicalReaction
comment: Definition: A continuant that encodes information that can be inherited through replication. Rationale: Gene is an abstract continuant that can be best described as a "schema", a common conception commonly used by biologists to demark a component within genome. In BioPAX, Gene is considered a generalization over eukaryotic and prokaryotic genes and is used only in genetic interactions. Gene is often confused with DNA and RNA fragments, however, these are considered the physical encoding of a gene. N.B. Gene expression regulation makes use of DNA and RNA physical entities and not this class. Usage: Gene should only be used for describing GeneticInteractions.
comment: Definition: A continuant that encodes information that can be inherited through replication. Rationale: Gene is and abstract continuant that can be best described as a "schema". Gene in BioPAX is a generelization over eukaryotic and prokaryotic genes and used only for genetic interactions. Gene is often confused with DNA and RNA fragments that are physical encoding of the gene. Gene expression regulation makes use of DNA and RNA physical entities. Usage: Gene should only be used for describing GeneticInteractions.

GeneticInteraction
type: Class
subclass of: Interaction
subclass of: Restriction
  on property: phenotype
  cardinality: 1
subclass of: Restriction
  on property: interactionType
  max cardinality: 1
subclass of: Restriction
  on property: participant
  all values from: Gene
subclass of: Restriction
  on property: participant
  min cardinality: 2
disjoint with: Modulation
disjoint with: MolecularInteraction
disjoint with: Pathway
disjoint with: PhysicalEntity
disjoint with: Protein
disjoint with: Rna
disjoint with: RnaRegion
disjoint with: SmallMolecule
disjoint with: TemplateReaction
disjoint with: TemplateReactionRegulation
disjoint with: Transport
disjoint with: TransportWithBiochemicalReaction
comment: Definition : Genetic interactions between genes occur when two genetic perturbations (e.g. mutations) have a combined phenotypic effect not caused by either perturbation alone. A gene participant in a genetic interaction represents the gene that is perturbed. Genetic interactions are not physical interactions but logical (AND) relationships. Their physical manifestations can be complex and span an arbitarily long duration. Rationale: Currently, BioPAX provides a simple definition that can capture most genetic interactions described in the literature. In the future, if required, the definition can be extended to capture other logical relationships and different, participant specific phenotypes. Example: A synthetic lethal interaction occurs when cell growth is possible without either gene A OR B, but not without both gene A AND B. If you knock out A and B together, the cell will die.
comment: Definition : Genetic interactions between genes occur when two genetic perturbations (e.g. mutations) have a combined phenotypic effect not caused by either perturbation alone. A gene participant in a genetic interaction represents the gene that is perturbed. Genetic interactions are not physical interactios but logical (AND) relationships. Their physical manifestations can be complex and span an arbitarily long duration. Rationale: Currently, BioPAX provides a simple definition that can capture most genetic interactions described in the literature. In the future, if required, the definition can be extended to capture other logical relationships and different, participant specific phenotypes. Example: A synthetic lethal interaction occurs when cell growth is possible without either gene A OR B, but not without both gene A AND B. If you knock out A and B together, the cell will die.

Interaction
type: Class
subclass of: Entity
disjoint with: Pathway
disjoint with: PhysicalEntity
disjoint with: Protein
disjoint with: Rna
disjoint with: RnaRegion
disjoint with: SmallMolecule
comment: Definition: A biological relationship between two or more entities. Rationale: BioPAX interactions are atomic from modeling perspective, i.e. it is not possible to define sub-interactions. For representing non-atomic continuants with explicit subevents, pathway class should be used. Interactions does not have to be temporally atomic though, for example genetic interactions cover a large span of time. Usage: Interaction is a highly abstract class and in almost all cases it is more appropriate to use subclasses of interaction. It is partially possible to define generic reactions by using generic participants. A more comprehensive method is planned for BioPAX L4 for covering all generic cases like oxidization of a generic alcohol. Synonyms: Process, relationship, event. Examples: protein-protein interaction, biochemical reaction, enzyme catalysis
comment: Definition: A biological relationship between two or more entities. Rationale: In BioPAX, interactions are atomic from a database modeling perspective, i.e. interactions can not be decomposed into sub-interactions. When representing non-atomic continuants with explicit subevents the pathway class should be used instead. Interactions are not necessarily temporally atomic, for example genetic interactions cover a large span of time. Interactions as a formal concept is a continuant, it retains its identitiy regardless of time, or any differences in specific states or properties. Usage: Interaction is a highly abstract class and in almost all cases it is more appropriate to use one of the subclasses of interaction. It is partially possible to define generic reactions by using generic participants. A more comprehensive method is planned for BioPAX L4 for covering all generic cases like oxidization of a generic alcohol. Synonyms: Process, relationship, event. Examples: protein-protein interaction, biochemical reaction, enzyme catalysis

InteractionVocabulary
type: Class
subclass of: ControlledVocabulary
disjoint with: KPrime
disjoint with: ModificationFeature
disjoint with: PathwayStep
disjoint with: PhenotypeVocabulary
disjoint with: ProteinReference
disjoint with: Provenance
disjoint with: PublicationXref
disjoint with: RelationshipTypeVocabulary
disjoint with: RelationshipXref
disjoint with: RnaReference
disjoint with: RnaRegionReference
disjoint with: Score
disjoint with: SequenceInterval
disjoint with: SequenceLocation
disjoint with: SequenceModificationVocabulary
disjoint with: SequenceRegionVocabulary
disjoint with: SequenceSite
disjoint with: SmallMoleculeReference
disjoint with: Stoichiometry
disjoint with: TissueVocabulary
disjoint with: UnificationXref
disjoint with: Xref
comment: Definition: A reference to the PSI Molecular Interaction ontology (MI) interaction type. Homepage at http://www.psidev.info/. Browse at http://www.ebi.ac.uk/ontology-lookup/browse.do?ontName=MI&termId=MI%3A0190&termName=interaction%20type

KPrime
type: Class
subclass of: UtilityClass
subclass of: Restriction
  on property: kPrime
  cardinality: 1
disjoint with: ModificationFeature
disjoint with: PathwayStep
disjoint with: PhenotypeVocabulary
disjoint with: ProteinReference
disjoint with: Provenance
disjoint with: PublicationXref
disjoint with: RelationshipTypeVocabulary
disjoint with: RelationshipXref
disjoint with: RnaReference
disjoint with: RnaRegionReference
disjoint with: Score
disjoint with: SequenceInterval
disjoint with: SequenceLocation
disjoint with: SequenceModificationVocabulary
disjoint with: SequenceRegionVocabulary
disjoint with: SequenceSite
disjoint with: SmallMoleculeReference
disjoint with: Stoichiometry
disjoint with: TissueVocabulary
disjoint with: UnificationXref
disjoint with: Xref
comment: Definition: The apparent equilibrium constant, K', and associated values. Usage: Concentrations in the equilibrium constant equation refer to the total concentrations of all forms of particular biochemical reactants. For example, in the equilibrium constant equation for the biochemical reaction in which ATP is hydrolyzed to ADP and inorganic phosphate: K' = [ADP][Pi]/[ATP], The concentration of ATP refers to the total concentration of all of the following species: [ATP] = [ATP4-] + [HATP3-] + [H2ATP2-] + [MgATP2-] + [MgHATP-] + [Mg2ATP]. The apparent equilibrium constant is formally dimensionless, and can be kept so by inclusion of as many of the terms (1 mol/dm3) in the numerator or denominator as necessary. It is a function of temperature (T), ionic strength (I), pH, and pMg (pMg = -log10[Mg2+]). Therefore, these quantities must be specified to be precise, and values for KEQ for biochemical reactions may be represented as 5-tuples of the form (K' T I pH pMg). This property may have multiple values, representing different measurements for K' obtained under the different experimental conditions listed in the 5-tuple. (This definition adapted from EcoCyc) See http://www.chem.qmul.ac.uk/iubmb/thermod/ for a thermodynamics tutorial.

ModificationFeature
type: Class
subclass of: EntityFeature
disjoint with: PathwayStep
disjoint with: PhenotypeVocabulary
disjoint with: ProteinReference
disjoint with: Provenance
disjoint with: PublicationXref
disjoint with: RelationshipTypeVocabulary
disjoint with: RelationshipXref
disjoint with: RnaReference
disjoint with: RnaRegionReference
disjoint with: Score
disjoint with: SequenceInterval
disjoint with: SequenceLocation
disjoint with: SequenceModificationVocabulary
disjoint with: SequenceRegionVocabulary
disjoint with: SequenceSite
disjoint with: SmallMoleculeReference
disjoint with: Stoichiometry
disjoint with: TissueVocabulary
disjoint with: UnificationXref
disjoint with: Xref
comment: Definition: An entity feature that represents the covalently modified state of a dna, rna or a protein. Rationale: In Biology, identity of DNA, RNA and Protein entities are defined around a wildtype sequence. Covalent modifications to this basal sequence are represented using modificaton features. Since small molecules are identified based on their chemical structure, not sequence, a covalent modification to a small molecule would result in a different molecule. Usage: The added groups should be simple and stateless, such as phosphate or methyl groups and are captured by the modificationType controlled vocabulary. In other cases, such as covalently linked proteins, use CovalentBindingFeature instead. Instances: A phosphorylation on a protein, a methylation on a DNA.

Modulation
type: Class
subclass of: Control
subclass of: Restriction
  on property: controller
  all values from: PhysicalEntity
subclass of: Restriction
  on property: controlled
  all values from: Catalysis
disjoint with: MolecularInteraction
disjoint with: Pathway
disjoint with: PhysicalEntity
disjoint with: Protein
disjoint with: Rna
disjoint with: RnaRegion
disjoint with: SmallMolecule
disjoint with: TemplateReaction
disjoint with: TemplateReactionRegulation
disjoint with: Transport
disjoint with: TransportWithBiochemicalReaction
comment: Definition: A control interaction in which a physical entity modulates a catalysis interaction. Biologically, most modulation interactions describe an interaction in which a small molecule alters the ability of an enzyme to catalyze a specific reaction. Instances of this class describe a pairing between a modulating entity and a catalysis interaction. Comment: A separate modulation instance should be created for each different catalysis instance that a physical entity may modulate and for each different physical entity that may modulate a catalysis instance. A typical modulation instance has a small molecule as the controller entity and a catalysis instance as the controlled entity. Examples: Allosteric activation and competitive inhibition of an enzyme's ability to catalyze a specific reaction.
comment: Definition: A control interaction in which a physical entity modulates a catalysis interaction. Rationale: Biologically, most modulation interactions describe an interaction in which a small molecule alters the ability of an enzyme to catalyze a specific reaction. Instances of this class describe a pairing between a modulating entity and a catalysis interaction. Usage: A typical modulation instance has a small molecule as the controller entity and a catalysis instance as the controlled entity. A separate modulation instance should be created for each different catalysis instance that a physical entity may modulate, and for each different physical entity that may modulate a catalysis instance. Examples: Allosteric activation and competitive inhibition of an enzyme's ability to catalyze a specific reaction.
comment: Definition: A control interaction in which a physical entity modulates a catalysis interaction. Rationale: Biologically, most modulation interactions describe an interaction in which a small molecule alters the ability of an enzyme to catalyze a specific reaction. Instances of this class describe a pairing between a modulating entity and a catalysis interaction. Usage: A separate modulation instance should be created for each different catalysis instance that a physical entity may modulate and for each different physical entity that may modulate a catalysis instance. A typical modulation instance has a small molecule as the controller entity and a catalysis instance as the controlled entity. Examples: Allosteric activation and competitive inhibition of an enzyme's ability to catalyze a specific reaction.

MolecularInteraction
type: Class
subclass of: Interaction
subclass of: Restriction
  on property: participant
  all values from: PhysicalEntity
disjoint with: Pathway
disjoint with: PhysicalEntity
disjoint with: Protein
disjoint with: Rna
disjoint with: RnaRegion
disjoint with: SmallMolecule
disjoint with: TemplateReactionRegulation
comment: Definition: An interaction in which participants bind physically to each other, directly or indirectly through intermediary molecules. Rationale: There is a large body of interaction data, mostly produced by high throughput systems, that does not satisfy the level of detail required to model them with ComplexAssembly class. Specifically, what is lacking is the stoichiometric information and completeness (closed-world) of participants required to model them as chemical processes. Nevertheless interaction data is extremely useful and can be captured in BioPAX using this class. Usage: This class should be used by default for representing molecular interactions such as those defined by PSI-MI level 2.5. The participants in a molecular interaction should be listed in the PARTICIPANT slot. Note that this is one of the few cases in which the PARTICPANT slot should be directly populated with instances (see comments on the PARTICPANTS property in the interaction class description). If all participants are known with exact stoichiometry, ComplexAssembly class should be used instead. Example: Two proteins observed to interact in a yeast-two-hybrid experiment where there is not enough experimental evidence to suggest that the proteins are forming a complex by themselves without any indirect involvement of other proteins. This is the case for most large-scale yeast two-hybrid screens.
comment: Definition: An interaction in which participants bind physically to each other,directly or indirectly through intermediary molecules. Rationale: There is a large body of interaction data, mostly produced by high throughput systems, that does not satisfy the level of detail required to model them with ComplexAssembly class. Specifically, what is lacking is the stoichiometric information and completeness ( closed-world) of participants required to model them as chemical processes. Nevertheless interaction data is extremely useful and can be captured in BioPAX using this class. Usage: This class should be used by default for representing molecular interactions, such as those defined by PSI-MI level 2.5. The participants in a molecular interaction should be listed in the PARTICIPANTS slot. Note that this is one of the few cases in which the PARTICPANT slot should be directly populated with instances (see comments on the PARTICPANTS property in the interaction class description). If all participants are known with exact stoichiometry, ComplexAssembly class should be used instead. Example: Two proteins observed to interact in a yeast-two-hybrid experiment where there is not enough experimental evidence to suggest that the proteins are forming a complex by themselves without any indirect involvement of other proteins. This is the case for most large-scale yeast two-hybrid screens.

Pathway
type: Class
subclass of: Entity
disjoint with: PhysicalEntity
disjoint with: Protein
disjoint with: Rna
disjoint with: RnaRegion
disjoint with: SmallMolecule
disjoint with: TemplateReaction
disjoint with: TemplateReactionRegulation
disjoint with: Transport
disjoint with: TransportWithBiochemicalReaction
comment: Definition: A set or series of interactions, often forming a network, which biologists have found useful to group together for organizational, historic, biophysical or other reasons. Usage: Pathways can be used for demarcating any subnetwork of a BioPAX model. It is also possible to define a pathway without specifying the interactions within the pathway. In this case, the pathway instance could consist simply of a name and could be treated as a 'black box'. Pathways can also soverlap, i.e. a single interaction might belong to multiple pathways. Pathways can also contain sub-pathways. Pathways are continuants. Synonyms: network, module, cascade, Examples: glycolysis, valine biosynthesis, EGFR signaling
comment: Definition: A set or series of interactions, often forming a network, which biologists have found useful to group together for organizational, historic, biophysical or other reasons. Usage: Pathways can be used for demarcating any subnetwork of a BioPAX model. It is also possible to define a pathway without specifying the interactions within the pathway. In this case, the pathway instance could consist simply of a name and could be treated as a 'black box'. Pathways can overlap, i.e. a single interaction might belong to multiple pathways. Pathways can also contain sub-pathways. Synonyms: network, module, cascade, Examples: glycolysis, valine biosynthesis, EGFR signaling

PathwayStep
type: Class
subclass of: UtilityClass
disjoint with: PhenotypeVocabulary
disjoint with: ProteinReference
disjoint with: Provenance
disjoint with: PublicationXref
disjoint with: RelationshipTypeVocabulary
disjoint with: RelationshipXref
disjoint with: RnaReference
disjoint with: RnaRegionReference
disjoint with: Score
disjoint with: SequenceInterval
disjoint with: SequenceLocation
disjoint with: SequenceModificationVocabulary
disjoint with: SequenceRegionVocabulary
disjoint with: SequenceSite
disjoint with: SmallMoleculeReference
disjoint with: Stoichiometry
disjoint with: TissueVocabulary
disjoint with: UnificationXref
disjoint with: Xref
comment: Definition: A step in an ordered pathway. Rationale: Some pathways can have a temporal order. For example if the pathway boundaries is based on a perturbation phenotype link the pathway might start with the perturbing agent and end at gene expression leading to the observed changes. Pathway steps can represent directed compound graphs. Usage: Multiple interactions may occur in a pathway step, each should be listed in the STEP-INTERACTION property. Order relationships between pathway steps may be established with the NEXT-STEP slot. If the reaction contained in the step is a reversible biochemical reaction but physiologically has a direction in the context of this pathway, use Biochemical Pathway Step instead. Example: A metabolic pathway may contain a pathway step composed of one biochemical reaction (BR1) and one catalysis (CAT1) instance, where CAT1 describes the catalysis of BR1. The M phase of the cell cycle, defined as a pathway, precedes the G1 phase, also defined as a pathway.
comment: Definition: A step in an ordered pathway. Rationale: Some pathways can have a temporal order. For example, if the pathway boundaries are based on a perturbation phenotype link, the pathway might start with the perturbing agent and end at gene expression leading to the observed changes. Pathway steps can represent directed compound graphs. Usage: Multiple interactions may occur in a pathway step, each should be listed in the stepProcess property. Order relationships between pathway steps may be established with the nextStep slot. If the reaction contained in the step is a reversible biochemical reaction but physiologically has a direction in the context of this pathway, use the subclass BiochemicalPathwayStep. Example: A metabolic pathway may contain a pathway step composed of one biochemical reaction (BR1) and one catalysis (CAT1) instance, where CAT1 describes the catalysis of BR1. The M phase of the cell cycle, defined as a pathway, precedes the G1 phase, also defined as a pathway.

PhenotypeVocabulary
type: Class
subclass of: ControlledVocabulary
disjoint with: ProteinReference
disjoint with: Provenance
disjoint with: PublicationXref
disjoint with: RelationshipTypeVocabulary
disjoint with: RelationshipXref
disjoint with: RnaReference
disjoint with: RnaRegionReference
disjoint with: Score
disjoint with: SequenceInterval
disjoint with: SequenceLocation
disjoint with: SequenceModificationVocabulary
disjoint with: SequenceRegionVocabulary
disjoint with: SequenceSite
disjoint with: SmallMoleculeReference
disjoint with: Stoichiometry
disjoint with: TissueVocabulary
disjoint with: UnificationXref
disjoint with: Xref
comment: Definition: The phenotype measured in the experiment e.g. growth rate or viability of a cell. This is only the type, not the value e.g. for a synthetic lethal interaction, the phenotype is viability, specified by ID: PATO:0000169, "viability", not the value (specified by ID: PATO:0000718, "lethal (sensu genetics)". A single term in a phenotype controlled vocabulary can be referenced using the xref, or the PhenoXML describing the PATO EQ model phenotype description can be stored as a string in PATO-DATA.

Protein
type: Class
subclass of: PhysicalEntity
subclass of: Restriction
  on property: memberPhysicalEntity
  all values from: Protein
subclass of: Restriction
  on property: entityReference
  all values from: ProteinReference
disjoint with: ProteinReference
disjoint with: Rna
disjoint with: RnaReference
disjoint with: RnaRegion
disjoint with: RnaRegionReference
disjoint with: SmallMolecule
disjoint with: SmallMoleculeReference
disjoint with: TemplateReaction
disjoint with: TemplateReactionRegulation
disjoint with: Transport
disjoint with: TransportWithBiochemicalReaction
comment: Definition: A physical entity consisting of a sequence of amino acids; a protein monomer; a single polypeptide chain. Examples: The epidermal growth factor receptor (EGFR) protein.

ProteinReference
type: Class
subclass of: EntityReference
subclass of: Restriction
  on property: memberEntityReference
  all values from: ProteinReference
disjoint with: Provenance
disjoint with: PublicationXref
disjoint with: RelationshipTypeVocabulary
disjoint with: RelationshipXref
disjoint with: Rna
disjoint with: RnaReference
disjoint with: RnaRegion
disjoint with: RnaRegionReference
disjoint with: Score
disjoint with: SequenceInterval
disjoint with: SequenceLocation
disjoint with: SequenceModificationVocabulary
disjoint with: SequenceRegionVocabulary
disjoint with: SequenceSite
disjoint with: SmallMolecule
disjoint with: SmallMoleculeReference
disjoint with: Stoichiometry
disjoint with: TissueVocabulary
disjoint with: UnificationXref
disjoint with: Xref
comment: A protein reference is a grouping of several protein entities that are encoded by the same gene. Members can differ in celular location, sequence features and bound partners. Currently conformational states (such as open and closed) are not covered.
comment: Description: A protein reference is a grouping of several protein entities that are encoded by the same genetic sequence. Members can differ in any combination of cellular location, sequence features and bound partners. Rationale: Protein molecules, encoded by the same genetic sequence can be present in (combinatorially many) different states, as a result of post translational modifications and non-covalent bonds. Each state, chemically, is a different pool of molecules. They are, however, related to each other because: They all share the same "base" genetic sequence. They can only be converted to each other but not to any other protein Comments:Most Protein databases, including UniProt would map one to one with ProteinReferences in BioPAX.

Provenance
type: Class
subclass of: UtilityClass
subclass of: Restriction
  on property: Xref
  all values from: Class
    union of: PublicationXref
    union of: UnificationXref
subclass of: Restriction
  on property: xref
  all values from: Class
    union of: PublicationXref
    union of: UnificationXref
disjoint with: PublicationXref
disjoint with: RelationshipTypeVocabulary
disjoint with: RelationshipXref
disjoint with: RnaReference
disjoint with: RnaRegionReference
disjoint with: Score
disjoint with: SequenceInterval
disjoint with: SequenceLocation
disjoint with: SequenceModificationVocabulary
disjoint with: SequenceRegionVocabulary
disjoint with: SequenceSite
disjoint with: SmallMoleculeReference
disjoint with: Stoichiometry
disjoint with: TissueVocabulary
disjoint with: UnificationXref
disjoint with: Xref
comment: Definition: The direct source of a pathway data or score. Usage: This does not store the trail of sources from the generation of the data to this point, only the last known source, such as a database. The XREF property may contain a publicationXref referencing a publication describing the data source (e.g. a database publication). A unificationXref may be used e.g. when pointing to an entry in a database of databases describing this database. Examples: A database, scoring method or person name.
comment: Definition: The direct source of pathway data or score. Usage: This does not store the trail of sources from the generation of the data to this point, only the last known source, such as a database, tool or algorithm. The xref property may contain a publicationXref referencing a publication describing the data source (e.g. a database publication). A unificationXref may be used when pointing to an entry in a database of databases describing this database. Examples: A database, scoring method or person name.

PublicationXref
type: Class
subclass of: Xref
disjoint with: RelationshipTypeVocabulary
disjoint with: RnaReference
disjoint with: RnaRegionReference
disjoint with: Score
disjoint with: SequenceInterval
disjoint with: SequenceLocation
disjoint with: SequenceModificationVocabulary
disjoint with: SequenceRegionVocabulary
disjoint with: SequenceSite
disjoint with: SmallMoleculeReference
disjoint with: Stoichiometry
disjoint with: TissueVocabulary
disjoint with: UnificationXref
comment: Definition: An xref that defines a reference to a publication such as a book, journal article, web page, or software manual. Usage: The reference may or may not be in a database, although references to PubMed are preferred when possible. The publication should make a direct reference to the instance it is attached to. Publication xrefs should make use of PubMed IDs wherever possible. The DB property of an xref to an entry in PubMed should use the string "PubMed" and not "MEDLINE". Examples: PubMed:10234245

RelationshipTypeVocabulary
type: Class
subclass of: ControlledVocabulary
disjoint with: RelationshipXref
disjoint with: RnaReference
disjoint with: RnaRegionReference
disjoint with: Score
disjoint with: SequenceInterval
disjoint with: SequenceLocation
disjoint with: SequenceModificationVocabulary
disjoint with: SequenceRegionVocabulary
disjoint with: SequenceSite
disjoint with: SmallMoleculeReference
disjoint with: Stoichiometry
disjoint with: TissueVocabulary
disjoint with: UnificationXref
disjoint with: Xref
comment: Definition: Vocabulary for defining relationship Xref types. A reference to the PSI Molecular Interaction ontology (MI) Cross Reference type. Homepage at http://www.psidev.info/. Browse at http://www.ebi.ac.uk/ontology-lookup/browse.do?ontName=MI&termId=MI%3A0353&termName=cross-reference%20type

RelationshipXref
type: Class
subclass of: Xref
disjoint with: RnaReference
disjoint with: RnaRegionReference
disjoint with: Score
disjoint with: SequenceInterval
disjoint with: SequenceLocation
disjoint with: SequenceModificationVocabulary
disjoint with: SequenceRegionVocabulary
disjoint with: SequenceSite
disjoint with: SmallMoleculeReference
disjoint with: Stoichiometry
disjoint with: TissueVocabulary
comment: Definition: An xref that defines a reference to an entity in an external resource that does not have the same biological identity as the referring entity. Usage: There is currently no controlled vocabulary of relationship types for BioPAX, although one will be created in the future if a need develops. Examples: A link between a gene G in a BioPAX data collection, and the protein product P of that gene in an external database. This is not a unification xref because G and P are different biological entities (one is a gene and one is a protein). Another example is a relationship xref for a protein that refers to the Gene Ontology biological process, e.g. 'immune response,' that the protein is involved in.

Rna
type: Class
subclass of: PhysicalEntity
subclass of: Restriction
  on property: entityReference
  all values from: RnaReference
subclass of: Restriction
  on property: memberPhysicalEntity
  all values from: Rna
disjoint with: RnaReference
disjoint with: RnaRegion
disjoint with: RnaRegionReference
disjoint with: SmallMolecule
disjoint with: SmallMoleculeReference
disjoint with: TemplateReaction
disjoint with: TemplateReactionRegulation
disjoint with: Transport
disjoint with: TransportWithBiochemicalReaction
comment: Definition: A physical entity consisting of a sequence of ribonucleotide monophosphates; a ribonucleic acid. Usage: RNA should be used for pools of individual RNA molecules. For describing subregions on those molecules use RNARegion. Examples: messengerRNA, microRNA, ribosomalRNA. A specific example is the let-7 microRNA.

RnaReference
type: Class
subclass of: EntityReference
subclass of: Restriction
  on property: memberEntityReference
  all values from: RnaReference
subclass of: Restriction
  on property: subRegion
  all values from: RnaRegionReference
disjoint with: RnaRegion
disjoint with: RnaRegionReference
disjoint with: Score
disjoint with: SequenceInterval
disjoint with: SequenceLocation
disjoint with: SequenceModificationVocabulary
disjoint with: SequenceRegionVocabulary
disjoint with: SequenceSite
disjoint with: SmallMolecule
disjoint with: SmallMoleculeReference
disjoint with: Stoichiometry
disjoint with: TissueVocabulary
disjoint with: UnificationXref
disjoint with: Xref
comment: Defintion: A RNA reference is a grouping of several RNA entities that are either encoded by the same gene or replicates of the same genome. Members can differ in celular location, sequence features and bound partners. Currently conformational states (such as hairpin) are not covered.

RnaRegion
type: Class
subclass of: PhysicalEntity
subclass of: Restriction
  on property: memberPhysicalEntity
  all values from: RnaRegion
subclass of: Restriction
  on property: entityReference
  all values from: RnaRegionReference
disjoint with: RnaRegionReference
disjoint with: SmallMolecule
disjoint with: SmallMoleculeReference
disjoint with: TemplateReaction
disjoint with: TemplateReactionRegulation
disjoint with: Transport
disjoint with: TransportWithBiochemicalReaction
comment: Definition: A region on a RNA molecule. Usage: RNARegion is not a pool of independent molecules but a subregion on these molecules. As such, every RNARegion has a defining RNA molecule. Examples: CDS, 3' UTR, Hairpin

RnaRegionReference
type: Class
subclass of: EntityReference
subclass of: Restriction
  on property: subRegion
  all values from: RnaRegionReference
disjoint with: Score
disjoint with: SequenceInterval
disjoint with: SequenceLocation
disjoint with: SequenceModificationVocabulary
disjoint with: SequenceRegionVocabulary
disjoint with: SequenceSite
disjoint with: SmallMolecule
disjoint with: SmallMoleculeReference
disjoint with: Stoichiometry
disjoint with: TissueVocabulary
disjoint with: UnificationXref
disjoint with: Xref
comment: Definition: A RNA reference is a grouping of several RNA entities that are common in sequence and genomic position. Members can differ in celular location, sequence features, mutations and bound partners.
comment: Definition: A RNARegion reference is a grouping of several RNARegion entities that are common in sequence and genomic position. Members can differ in celular location, sequence features, mutations and bound partners.

Score
type: Class
subclass of: UtilityClass
subclass of: Restriction
  on property: value
  cardinality: 1
disjoint with: SequenceInterval
disjoint with: SequenceLocation
disjoint with: SequenceModificationVocabulary
disjoint with: SequenceRegionVocabulary
disjoint with: SequenceSite
disjoint with: SmallMoleculeReference
disjoint with: Stoichiometry
disjoint with: TissueVocabulary
disjoint with: UnificationXref
disjoint with: Xref
comment: Definition: A score associated with a publication reference describing how the score was determined, the name of the method and a comment briefly describing the method. Usage: The xref must contain at least one publication that describes the method used to determine the score value. There is currently no standard way of describing values, so any string is valid. Examples: The statistical significance of a result, e.g. "p<0.05".

SequenceInterval
type: Class
subclass of: SequenceLocation
disjoint with: SequenceModificationVocabulary
disjoint with: SequenceRegionVocabulary
disjoint with: SequenceSite
disjoint with: SmallMoleculeReference
disjoint with: Stoichiometry
disjoint with: TissueVocabulary
disjoint with: UnificationXref
disjoint with: Xref
comment: Definition: An interval on a sequence. Usage: Interval is defined as an ordered pair of SequenceSites. All of the sequence from the begin site to the end site (inclusive) is described, not any subset.
comment: Definition: An interval on a sequence. Usage: Inverval is defined as an ordered pair of SequenceSites. All of the sequence from the begin site to the end site (inclusive) is described, not any subset.

SequenceLocation
type: Class
subclass of: UtilityClass
disjoint with: SequenceModificationVocabulary
disjoint with: SequenceRegionVocabulary
disjoint with: SmallMoleculeReference
disjoint with: Stoichiometry
disjoint with: TissueVocabulary
disjoint with: UnificationXref
disjoint with: Xref
comment: Definition: A location on a nucleotide or amino acid sequence. Usage: For most purposes it is more appropriate to use subclasses of this class. Direct instances of SequenceLocation can be used for uknown locations that can not be classified neither as an interval nor a site.

SequenceModificationVocabulary
type: Class
subclass of: ControlledVocabulary
disjoint with: SequenceRegionVocabulary
disjoint with: SequenceSite
disjoint with: SmallMoleculeReference
disjoint with: Stoichiometry
disjoint with: TissueVocabulary
disjoint with: UnificationXref
disjoint with: Xref
comment: Definiiton: A reference to the PSI Molecular Interaction ontology (MI) of covalent sequence modifications. Homepage at http://www.psidev.info/. Browse at http://www.ebi.ac.uk/ontology-lookup/browse.do?ontName=MI&termId=MI%3A0252&termName=biological%20feature. Only children that are covelent modifications at specific positions can be used.

SequenceRegionVocabulary
type: Class
subclass of: ControlledVocabulary
disjoint with: SequenceSite
disjoint with: SmallMoleculeReference
disjoint with: Stoichiometry
disjoint with: TissueVocabulary
disjoint with: UnificationXref
disjoint with: Xref
comment: Definition: A reference to a controlled vocabulary of sequence regions, such as InterPro or Sequence Ontology (SO). Homepage at http://www.sequenceontology.org/. Browse at http://www.ebi.ac.uk/ontology-lookup/browse.do?ontName=SO

SequenceSite
type: Class
subclass of: SequenceLocation
disjoint with: SmallMoleculeReference
disjoint with: Stoichiometry
disjoint with: TissueVocabulary
disjoint with: UnificationXref
disjoint with: Xref
comment: Definition: Describes a site on a sequence, i.e. the position of a single nucleotide or amino acid. Usage: A sequence site is always defined based on the reference sequence of the owning entity. For DNARegion and RNARegion it is relative to the region itself not the genome or full RNA molecule.

SmallMolecule
type: Class
subclass of: PhysicalEntity
subclass of: Restriction
  on property: feature
  all values from: BindingFeature
subclass of: Restriction
  on property: notFeature
  all values from: BindingFeature
subclass of: Restriction
  on property: entityReference
  all values from: SmallMoleculeReference
subclass of: Restriction
  on property: memberPhysicalEntity
  all values from: SmallMolecule
disjoint with: SmallMoleculeReference
disjoint with: TemplateReaction
disjoint with: TemplateReactionRegulation
disjoint with: Transport
disjoint with: TransportWithBiochemicalReaction
comment: Definition: A pool of molecules that are neither complexes nor are genetically encoded. Rationale: Identity of small molecules are based on structure, rather than sequence as in the case of DNA, RNA or Protein. A small molecule reference is a grouping of several small molecule entities that have the same chemical structure. Usage : Smalle Molecules can have a cellular location and binding features. They can't have modification features as covalent modifications of small molecules are not considered as state changes but treated as different molecules. Some non-genomic macromolecules, such as large complex carbohydrates are currently covered by small molecules despite they lack a static structure. Better coverage for such molecules require representation of generic stoichiometry and polymerization, currently planned for BioPAX level 4. Examples: glucose, penicillin, phosphatidylinositol

SmallMoleculeReference
type: Class
subclass of: EntityReference
subclass of: Restriction
  on property: memberEntityReference
  all values from: SmallMoleculeReference
disjoint with: Stoichiometry
disjoint with: TissueVocabulary
disjoint with: UnificationXref
disjoint with: Xref
comment: A small molecule reference is a grouping of several small molecule entities that have the same chemical structure. Members can differ in celular location and bound partners. Covalent modifications of small molecules are not considered as state changes but treated as different molecules.

Stoichiometry
type: Class
subclass of: UtilityClass
subclass of: Restriction
  on property: physicalEntity
  cardinality: 1
subclass of: Restriction
  on property: stoichiometricCoefficient
  cardinality: 1
subclass of: Restriction
  on property: PhysicalEntity
  cardinality: 1
disjoint with: TissueVocabulary
disjoint with: UnificationXref
disjoint with: Xref
comment: Definition: Stoichiometric coefficient of a physical entity in the context of a conversion or complex. Usage: For each participating element there must be 0 or 1 stoichiometry element. A non-existing stoichiometric element is treated as unknown. This is an n-ary bridge for left, right and component properties. Relative stoichiometries ( e.g n, n+1) often used for describin polymerization is not supported.
comment: Definition: Stoichiometric coefficient of a physical entity in the context of a conversion or complex. Usage: For each participating element there must be 0 or 1 stoichiometry element. A non-existing stoichiometric element is treated as unknown. This is an n-ary bridge for left, right and component properties. Relative stoichiometries ( e.g n, n+1) often used for describing polymerization is not supported.

TemplateReaction
type: Class
subclass of: Interaction
subclass of: Restriction
  on property: participant
  all values from: PhysicalEntity
disjoint with: TemplateReactionRegulation
comment: Definiton: An interaction where a macromolecule is polymerized from a template macromolecule. Rationale: This is an abstraction over multiple (not explicitly stated) biochemical reactions. The ubiquitous molecules (NTP and amino acids) consumed are also usually omitted. Template reaction is non-stoichiometric, does not obey law of mass conservation and temporally non-atomic. It, however, provides a mechanism to capture processes that are central to all living organisms. Usage: Regulation of TemplateReaction, e.g. via a transcription factor can be captured using TemplateReactionRegulation. TemplateReaction can also be indirect for example, it is not necessary to represent intermediary mRNA for describing expression of a protein. It was decided to not subclass TemplateReaction to subtypes such as transcription of translation for the sake of simplicity. If needed these subclasses can be added in the future. Examples: Transcription, translation, replication, reverse transcription. E.g. DNA to RNA is transcription, RNA to protein is translation and DNA to protein is protein expression from DNA.
comment: Definiton: An interaction where a macromolecule is polymerized from a template macromolecule. Rationale: This is an abstraction over multiple (omitted) biochemical reactions. Ubiquitous molecules ( NTP and amino acids) consumed are also omitted. Template reaction is non-stoichiometric, does not obey law of mass conservation and temporally non-atomic. It, however, provides a mechanism to capture processes that are central to all living organisms. Usage: Regulation of TemplateReaction, e.g. via a transcription factor can be captured using TemplateReactionRegulation. TemplateReaction can also be indirect, for example it is not necessary to represent intermediary mRNA for describing expression of a protein. It was decided to not subclass TemplateReaction to subtypes such as transcription of translation for the sake of simplicity. If needed these subclasses can be added in the future. Examples: Transcription, translation, replication, reverse transcription. E.g. DNA to RNA is transcription, RNA to protein is translation and DNA to protein is protein expression from DNA.

TemplateReactionRegulation
type: Class
subclass of: Control
subclass of: Restriction
  on property: controlType
  all values from: Datatype
    one of: ACTIVATION
    one of: INHIBITION
subclass of: Restriction
  on property: controller
  all values from: PhysicalEntity
subclass of: Restriction
  on property: controlled
  all values from: TemplateReaction
disjoint with: Transport
disjoint with: TransportWithBiochemicalReaction
comment: Definition: Regulation of an expression reaction by a controlling element such as a transcription factor or microRNA. Usage: To represent the binding of the transcription factor to a regulatory element in the TemplateReaction, create a complex of the transcription factor and the regulatory element and set that as the controller.
comment: Definition: Regulation of the expression reaction by the controlling element such as a transcription factor or microRNA. E.g. To represent the binding of the transcription factor to a regulatory element in the TemplateReaction, create a complex of the transcription factor and the regulatory element and set that as the controller.

TissueVocabulary
type: Class
subclass of: ControlledVocabulary
disjoint with: UnificationXref
disjoint with: Xref
comment: Definition: A reference to the BRENDA (BTO). Homepage at http://www.brenda-enzymes.info/. Browse at http://www.ebi.ac.uk/ontology-lookup/browse.do?ontName=BTO

Transport
type: Class
subclass of: Conversion
comment: Definition: An conversion in which molecules of one or more physicalEntity pools change their subcellular location and become a member of one or more other physicalEntity pools. A transport interaction does not include the transporter entity, even if one is required in order for the transport to occur. Instead, transporters are linked to transport interactions via the catalysis class. Usage: If there is a simultaneous chemical modification of the participant(s), use transportWithBiochemicalReaction class. Synonyms: translocation. Examples: The movement of Na+ into the cell through an open voltage-gated channel.

TransportWithBiochemicalReaction
type: Class
subclass of: BiochemicalReaction
subclass of: Transport
comment: Definition: A conversion interaction that is both a biochemicalReaction and a transport. In transportWithBiochemicalReaction interactions, one or more of the substrates change both their location and their physical structure. Active transport reactions that use ATP as an energy source fall under this category, even if the only covalent change is the hydrolysis of ATP to ADP. Rationale: This class was added to support a large number of transport events in pathway databases that have a biochemical reaction during the transport process. It is not expected that other double inheritance subclasses will be added to the ontology at the same level as this class. Examples: In the PEP-dependent phosphotransferase system, transportation of sugar into an E. coli cell is accompanied by the sugar's phosphorylation as it crosses the plasma membrane.
comment: Definition: A conversion interaction that is both a biochemicalReaction and a transport. In transportWithBiochemicalReaction interactions, one or more of the substrates changes both their location and their physical structure. Active transport reactions that use ATP as an energy source fall under this category, even if the only covalent change is the hydrolysis of ATP to ADP. Rationale: This class was added to support a large number of transport events in pathway databases that have a biochemical reaction during the transport process. It is not expected that other double inheritance subclasses will be added to the ontology at the same level as this class. Examples: In the PEP-dependent phosphotransferase system, transportation of sugar into an E. coli cell is accompanied by the sugar's phosphorylation as it crosses the plasma membrane.

UnificationXref
type: Class
subclass of: Xref
subclass of: Restriction
  on property: id
  cardinality: 1
subclass of: Restriction
  on property: db
  cardinality: 1
comment: Definition: A unification xref defines a reference to an entity in an external resource that has the same biological identity as the referring entity Rationale: Unification xrefs are critically important for data integration. In the future they can be replaced by direct miriam links and rdf:id based identity management. Usage: For example, if one wished to link from a database record, C, describing a chemical compound in a BioPAX data collection to a record, C', describing the same chemical compound in an external database, one would use a unification xref since records C and C' describe the same biological identity. Generally, unification xrefs should be used whenever possible, although there are cases where they might not be useful, such as application to application data exchange.Identity of interactions can be computed based on the identity of its participants. An xref in a protein pointing to a gene, e.g. in the LocusLink database17, would not be a unification xref since the two entities do not have the same biological identity (one is a protein, the other is a gene). Instead, this link should be a captured as a relationship xref. References to an external controlled vocabulary term within the OpenControlledVocabulary class should use a unification xref where possible (e.g. GO:0005737). Examples: An xref in a protein instance pointing to an entry in the Swiss-Prot database, and an xref in an RNA instance pointing to the corresponding RNA sequence in the RefSeq database..
comment: Definition: A unification xref defines a reference to an entity in an external resource that has the same biological identity as the referring entity Rationale: Unification xrefs are critically important for data integration. In the future they may be replaced by direct miriam links and rdf:id based identity management. Usage: For example, if one wished to link from a database record, C, describing a chemical compound in a BioPAX data collection to a record, C', describing the same chemical compound in an external database, one would use a unification xref since records C and C' describe the same biological identity. Generally, unification xrefs should be used whenever possible, although there are cases where they might not be useful, such as application to application data exchange.Identity of interactions can be computed based on the identity of its participants. An xref in a protein pointing to a gene, e.g. in the LocusLink database17, would not be a unification xref since the two entities do not have the same biological identity (one is a protein, the other is a gene). Instead, this link should be a captured as a relationship xref. References to an external controlled vocabulary term within the OpenControlledVocabulary class should use a unification xref where possible (e.g. GO:0005737). Examples: An xref in a protein instance pointing to an entry in the Swiss-Prot database, and an xref in an RNA instance pointing to the corresponding RNA sequence in the RefSeq database..

UtilityClass
type: Class
comment: Definition: This is a placeholder for classes, used for annotating the "Entity" and its subclasses but are not an "Entity" themselves. Examples include references to external databases, controlled vocabularies, evidence and provenance. Rationale: Utility classes are created when simple slots are insufficient to describe an aspect of an entity or to increase compatibility of this ontology with other standards. Usage: The utilityClass class is actually a metaclass and is only present to organize the other helper classes under one class hierarchy; instances of utilityClass should never be created.
comment: Definition: This is a placeholder for classes, used for annotating the "Entity" and its subclasses. Mostly, these are not an "Entity" themselves. Examples include references to external databases, controlled vocabularies, evidence and provenance. Rationale: Utility classes are created when simple slots are insufficient to describe an aspect of an entity or to increase compatibility of this ontology with other standards. Usage: The utilityClass class is actually a metaclass and is only present to organize the other helper classes under one class hierarchy; instances of utilityClass should never be created.

FDA Adverse Reporting System
type: NamedIndividual
type: Public Reporting Database
comment: The FDA's Adverse Event Reporting System: http://www.fda.gov/cder/aers/default.htm

Parallel groups assignment
type: NamedIndividual
type: Non randomized Tx Assignment
type: Treatment Assignment
comment: A pharmacokinetic clinical trial study design involving two groups of non-randomized participants where both groups recieve the purported object drug while only one group receives the purported precipitant

US Food and Drug Administration
type: NamedIndividual
type: Authoriative Organization
comment: The US Food and Drug Administration (FDA): http://www.fda.gov/opacom/hpview.html

human liver microsomes
type: NamedIndividual
type: Microsomes
type: in vitro Protein Source
comment: human liver microsomes

recombinant human cytochrome P450 isoenzymes
type: NamedIndividual
type: Recombinant Protein System
type: in vitro Protein Source
comment: recombinant human cytochrome P450 isoenzymes

simvastatin
type: NamedIndividual
type: Drug
comment: "A derivative of LOVASTATIN and potent competitive inhibitor of 3-hydroxy-3-methylglutaryl coenzyme A reductase (HYDROXYMETHYLGLUTARYL COA REDUCTASES), which is the rate-limiting enzyme in cholesterol biosynthesis. It may also interfere with steroid hormone production. Due to the induction of hepatic LDL RECEPTORS, it increases breakdown of LDL-cholesterol (LIPOPROTEINS, LDL CHOLESTEROL)." (MeSH D019821)
unifies with x ref: unificationXref 4

unificationXref 4
type: NamedIndividual
type: UnificationXref
type: UtilityClass
type: Xref
ID: C22028
DB: VA_NDFRT

Coverage
description: Coverage will typically include spatial location (a place name or geographic coordinates), temporal period (a period label, date, or date range) or jurisdiction (such as a named administrative entity). Recommended best practice is to select a value from a controlled vocabulary (for example, the Thesaurus of Geographic Names [TGN]) and that, where appropriate, named places or time periods be used in preference to numeric identifiers such as sets of coordinates or date ranges.
comment: The extent or scope of the content of the resource.

Subject and Keywords
comment: The topic of the content of the resource.
description: Typically, a Subject will be expressed as keywords, key phrases or classification codes that describe a topic of the resource. Recommended best practice is to select a value from a controlled vocabulary or formal classification scheme.

Resource Type
comment: The nature or genre of the content of the resource.
description: Type includes terms describing general categories, functions, genres, or aggregation levels for content. Recommended best practice is to select a value from a controlled vocabulary (for example, the DCMI Type Vocabulary [DCMITYPE]). To describe the physical or digital manifestation of the resource, use the Format element.

Resource Identifier
comment: An unambiguous reference to the resource within a given context.
description: Recommended best practice is to identify the resource by means of a string or number conforming to a formal identification system. Example formal identification systems include the Uniform Resource Identifier (URI) (including the Uniform Resource Locator (URL)), the Digital Object Identifier (DOI) and the International Standard Book Number (ISBN).

double blind crossover design
variant: double blind crossover designs
variant: double blind crossover studies
variant: double blind crossover study
variant: double blind crossover trial
variant: double blind crossover trials
variant: double-blind crossover design
variant: double-blind crossover designs
variant: double-blind crossover studies
variant: double-blind crossover study
variant: double-blind crossover trial
variant: double-blind crossover trials
editor: Ashleigh Faith
semantic type: Research Activity
me SH code: D004311
legacy term: Research design [1977-1989]

Relation
description: Recommended best practice is to reference the resource by means of a string or number conforming to a formal identification system.
comment: A reference to a related resource.

Rights Management
description: Typically, a Rights element will contain a rights management statement for the resource, or reference a service providing such information. Rights information often encompasses Intellectual Property Rights (IPR), Copyright, and various Property Rights. If the Rights element is absent, no assumptions can be made about the status of these and other rights with respect to the resource.
comment: Information about rights held in and over the resource.

literature review
variant: review, academic
variant: review of literature
me SH code: D016454
variant: reviews
variant: review literature
variant: review
definition: An article or book published after examination of published material on a subject. It may be comprehensive to various degrees and the time range of material scrutinized may be broad or narrow, but the reviews most often desired are reviews of the current literature. The textual material examined may be equally broad and can encompass, in medicine specifically, clinical material as well as experimental research or case reports. State-of-the-art reviews tend to address more current matters. [MeSH_2014]
variant: literature reviews
variant: review, multicase
variant: review of reported cases
editor: Ashleigh Faith
semantic type: Intellectual Product
definition: Significant review of original research. [Emtree_2014]

randomized clinical trial
variant: randomised clinical design
variant: randomised clinical designs
variant: randomised clinical studies
variant: randomised clinical study
variant: randomised clinical trial
variant: randomised clinical trials
variant: randomized clinical design
variant: randomized clinical designs
variant: randomized clinical studies
variant: randomized clinical study
variant: randomized clinical trials
UMLS CUI: C0206034
editor: Ashleigh Faith
semantic type: Research Activity
definition: A study in which the participants are assigned by chance to separate groups that compare different treatments; neither the researchers nor the participants can choose which group. Using chance to assign people to groups means that the groups will be similar and that the treatments they receive can be compared objectively. At the time of the trial, it is not known which treatment is best. It is the patient's choice to be in a randomized trial. [NCIT_14.05d]
definition: Used as a drug subheading when the clinical trial of a drug is reported. [Clinical trial | Embase_2014]
NCI thesaurus code: C15417
definition: Used for original reports of prospective clinical studies in which the (comparative) efficacy of one or more medical interventions in humans is evaluated; also used for prospective clinical veterinary trials in which the (comparative) efficacy of one or more medical interventions in animals is evaluated. [Clinical trial | Embase_2014]

Language
comment: A language of the intellectual content of the resource.
description: Recommended best practice is to use RFC 3066 [RFC3066], which, in conjunction with ISO 639 [ISO639], defines two- and three-letter primary language tags with optional subtags. Examples include "en" or "eng" for English, "akk" for Akkadian, and "en-GB" for English used in the United Kingdom.